locus-tag	class	description
CG475_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CG475_000010	COG0592	DNA-directed DNA polymerase activity
CG475_000015	COG2501	S4 domain
CG475_000020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CG475_000025	COG0187	DNA topoisomerase II activity
CG475_000030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG475_000065	COG0517	IMP dehydrogenase activity
CG475_000065	COG0516	GMP reductase activity
CG475_000070	COG1686	Belongs to the peptidase S11 family
CG475_000075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CG475_000080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CG475_000085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CG475_000100	COG1428	Deoxynucleoside kinase
CG475_000105	COG1428	Deoxynucleoside kinase
CG475_000110	COG1335	isochorismatase
CG475_000115	COG0590	tRNA wobble adenosine to inosine editing
CG475_000125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CG475_000130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CG475_000135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CG475_000180	COG1982	Orn Lys Arg decarboxylase major
CG475_000185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CG475_000190	COG0470	DNA polymerase III
CG475_000195	COG1774	PSP1 C-terminal conserved region
CG475_000200	COG4467	Involved in initiation control of chromosome replication
CG475_000205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CG475_000215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CG475_000220	COG2002	toxin-antitoxin pair type II binding
CG475_000230	COG0084	hydrolase, TatD family'
CG475_000240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CG475_000250	COG4466	Protein conserved in bacteria
CG475_000260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CG475_000265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG475_000270	COG0251	oxidation-reduction process
CG475_000275	COG2088	sporulation resulting in formation of a cellular spore
CG475_000280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CG475_000285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CG475_000290	COG0193	aminoacyl-tRNA hydrolase activity
CG475_000300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CG475_000305	COG2002	toxin-antitoxin pair type II binding
CG475_000310	COG2244	polysaccharide biosynthetic process
CG475_000315	COG3956	TIGRFAM MazG family protein
CG475_000320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CG475_000340	COG1098	S1 RNA binding domain
CG475_000355	COG2208	phosphoserine phosphatase activity
CG475_000370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CG475_000375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CG475_000380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CG475_000385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG475_000390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CG475_000395	COG0512	Glutamine amidotransferase of anthranilate synthase
CG475_000400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG475_000405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CG475_000410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CG475_000415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CG475_000420	COG1396	sequence-specific DNA binding
CG475_000425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG475_000430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CG475_000465	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG475_000515	COG3880	PFAM UvrB UvrC protein
CG475_000520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CG475_000525	COG0542	response to heat
CG475_000530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CG475_000540	COG4956	integral membrane protein (PIN domain superfamily)
CG475_000545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CG475_000550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CG475_000555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CG475_000560	COG1045	serine acetyltransferase
CG475_000565	COG0215	cysteine-tRNA ligase activity
CG475_000575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG475_000580	COG3688	RNA-binding protein containing a PIN domain
CG475_000600	COG0250	Participates in transcription elongation, termination and antitermination
CG475_000610	COG0081	regulation of translation
CG475_000615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CG475_000620	COG0222	ribosome binding
CG475_000625	COG2813	Specifically methylates the guanine in position
CG475_000635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CG475_000640	COG1358	cellular component organization or biogenesis
CG475_000645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CG475_000650	COG0049	tRNA binding
CG475_000655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CG475_000660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CG475_000670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CG475_000675	COG0088	Forms part of the polypeptide exit tunnel
CG475_000680	COG0089	rRNA binding
CG475_000685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CG475_000690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CG475_000695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CG475_000700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CG475_000705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CG475_000715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CG475_000720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CG475_000725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CG475_000730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CG475_000740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CG475_000745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CG475_000750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CG475_000755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CG475_000760	COG1841	ribosomal large subunit assembly
CG475_000765	COG0200	Binds to the 23S rRNA
CG475_000770	COG0201	protein transport
CG475_000775	COG0563	adenylate kinase activity
CG475_000780	COG0024	Methionine aminopeptidase
CG475_000790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CG475_000800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CG475_000805	COG0202	RNA polymerase activity
CG475_000820	COG1122	ATPase activity
CG475_000825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG475_000835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CG475_000840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CG475_000850	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG475_000855	COG0489	protein tyrosine kinase activity
CG475_000865	COG2194	sulfuric ester hydrolase activity
CG475_000870	COG0726	polysaccharide deacetylase
CG475_000900	COG4974	Belongs to the 'phage' integrase family
CG475_001055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CG475_001065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG475_001105	COG1396	sequence-specific DNA binding
CG475_001110	COG0602	queuosine metabolic process
CG475_001220	COG3681	Belongs to the UPF0597 family
CG475_001225	COG3681	Belongs to the UPF0597 family
CG475_001250	COG2814	Major facilitator Superfamily
CG475_001260	COG0601	transmembrane transport
CG475_001265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG475_001270	COG0444	Belongs to the ABC transporter superfamily
CG475_001275	COG4608	Belongs to the ABC transporter superfamily
CG475_001280	COG4166	transmembrane transport
CG475_001290	COG2207	Transcriptional regulator
CG475_001300	COG1309	transcriptional regulator
CG475_001310	COG0656	L-ascorbic acid biosynthetic process
CG475_001315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG475_001325	COG4149	molybdate abc transporter
CG475_001330	COG0725	ABC transporter, periplasmic molybdate-binding protein
CG475_001335	COG1910	domain protein
CG475_001340	COG0204	Acyl-transferase
CG475_001345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG475_001350	COG1648	precorrin-2 dehydrogenase activity
CG475_001350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG475_001360	COG1587	Uroporphyrinogen-III synthase
CG475_001360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG475_001365	COG2146	nitrite reductase [NAD(P)H] activity
CG475_001370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG475_001400	COG4585	Histidine kinase
CG475_001405	COG2197	response regulator
CG475_001410	COG1131	(ABC) transporter
CG475_001415	COG0842	Transport permease protein
CG475_001415	COG1511	domain protein
CG475_001420	COG0842	Transport permease protein
CG475_001430	COG0747	negative chemotaxis
CG475_001435	COG0601	transmembrane transport
CG475_001440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG475_001445	COG0444	Belongs to the ABC transporter superfamily
CG475_001450	COG4608	Belongs to the ABC transporter superfamily
CG475_001455	COG0561	phosphatase activity
CG475_001475	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CG475_001480	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG475_001490	COG2814	Major facilitator Superfamily
CG475_001495	COG1181	Belongs to the D-alanine--D-alanine ligase family
CG475_001500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CG475_001510	COG0457	Tetratricopeptide repeat
CG475_001510	COG0705	Rhomboid family
CG475_001515	COG0736	holo-[acyl-carrier-protein] synthase activity
CG475_001520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CG475_001530	COG0864	Transcriptional regulator
CG475_001535	COG2337	Toxic component of a toxin-antitoxin (TA) module
CG475_001540	COG2183	response to ionizing radiation
CG475_001550	COG3091	SprT-like family
CG475_001590	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG475_001640	COG0802	atpase or kinase
CG475_001645	COG1214	PFAM Peptidase M22, glycoprotease
CG475_001650	COG0456	acetyltransferase
CG475_001660	COG0488	(ABC) transporter
CG475_001665	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CG475_001675	COG1266	CAAX protease self-immunity
CG475_001680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CG475_001685	COG0459	protein refolding
CG475_001690	COG0519	Catalyzes the synthesis of GMP from XMP
CG475_001690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CG475_001695	COG2252	PERMEase
CG475_001705	COG5002	protein histidine kinase activity
CG475_001775	COG2205	protein histidine kinase activity
CG475_001780	COG0745	RESPONSE REGULATOR receiver
CG475_001800	COG0697	spore germination
CG475_001825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CG475_001830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CG475_001835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CG475_001840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CG475_001845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG475_001850	COG0047	phosphoribosylformylglycinamidine synthase activity
CG475_001855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG475_001860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CG475_001865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CG475_001870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CG475_001875	COG0138	bifunctional purine biosynthesis protein purh
CG475_001880	COG0151	Belongs to the GarS family
CG475_001890	COG0583	DNA-binding transcription factor activity
CG475_001910	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CG475_001915	COG0210	DNA helicase
CG475_001920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CG475_001925	COG4851	CamS sex pheromone cAM373 precursor
CG475_001935	COG1012	belongs to the aldehyde dehydrogenase family
CG475_001940	COG1335	isochorismatase
CG475_001950	COG2011	ABC-type metal ion transport system permease component
CG475_001955	COG1464	Belongs to the NlpA lipoprotein family
CG475_001970	COG4682	membrane
CG475_001975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG475_001980	COG0154	amidase activity
CG475_001985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG475_001990	COG1597	lipid kinase activity
CG475_001995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CG475_002000	COG0546	phosphoglycolate phosphatase activity
CG475_002005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CG475_002015	COG0531	amino acid
CG475_002020	COG1012	belongs to the aldehyde dehydrogenase family
CG475_002025	COG2076	Multidrug Resistance protein
CG475_002030	COG2309	aminopeptidase activity
CG475_002045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG475_002050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG475_002055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG475_002070	COG0450	alkyl hydroperoxide reductase
CG475_002095	COG0714	Associated with various cellular activities
CG475_002130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG475_002135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG475_002140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG475_002145	COG0492	ferredoxin-NADP+ reductase activity
CG475_002155	COG0166	Belongs to the GPI family
CG475_002160	COG5002	protein histidine kinase activity
CG475_002185	COG3541	Predicted nucleotidyltransferase
CG475_002190	COG2814	Major facilitator Superfamily
CG475_002195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG475_002195	COG0723	plastoquinol--plastocyanin reductase activity
CG475_002205	COG0765	amino acid transport
CG475_002210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG475_002215	COG1126	abc transporter atp-binding protein
CG475_002220	COG0840	transmembrane signaling receptor activity
CG475_002235	COG2235	arginine
CG475_002250	COG0549	Belongs to the carbamate kinase family
CG475_002265	COG0366	Alpha amylase catalytic
CG475_002270	COG1263	PTS System
CG475_002270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG475_002270	COG2190	(PTS) system
CG475_002290	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG475_002295	COG4605	iron ion homeostasis
CG475_002300	COG4604	ABC transporter, ATP-binding protein
CG475_002305	COG4607	ABC-type enterochelin transport system periplasmic component
CG475_002310	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CG475_002315	COG0352	thiamine-phosphate diphosphorylase activity
CG475_002320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CG475_002340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG475_002350	COG1116	anion transmembrane transporter activity
CG475_002430	COG2963	transposase activity
CG475_002435	COG2801	Transposase and inactivated derivatives
CG475_002440	COG2270	Major facilitator Superfamily
CG475_002465	COG2310	stress, protein
CG475_002470	COG2310	stress, protein
CG475_002475	COG2310	stress, protein
CG475_002480	COG0861	Integral membrane protein TerC family
CG475_002490	COG3853	Toxic anion resistance protein (TelA)
CG475_002500	COG4840	Belongs to the UPF0435 family
CG475_002505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG475_002515	COG1295	ribonuclease BN
CG475_002520	COG2217	Heavy metal translocating P-type atpase
CG475_002525	COG0697	spore germination
CG475_002535	COG0681	Belongs to the peptidase S26 family
CG475_002545	COG0586	Pfam SNARE associated Golgi protein
CG475_002560	COG0387	Pfam Sodium calcium exchanger
CG475_002570	COG0535	radical SAM domain protein
CG475_002590	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CG475_002615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG475_002640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG475_002670	COG2066	Belongs to the glutaminase family
CG475_002675	COG1263	PTS System
CG475_002675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG475_002680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG475_002690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG475_002690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG475_002700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CG475_002705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG475_002720	COG0402	S-adenosylhomocysteine deaminase activity
CG475_002725	COG2137	regulation of response to DNA damage stimulus
CG475_002750	COG1988	membrane-bound metal-dependent
CG475_002755	COG1194	a g-specific adenine glycosylase
CG475_002780	COG3557	Belongs to the UPF0374 family
CG475_002785	COG1132	(ABC) transporter
CG475_002790	COG4129	membrane
CG475_002795	COG0067	glutamate synthase
CG475_002795	COG0069	glutamate synthase activity
CG475_002795	COG0070	glutamate synthase
CG475_002800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG475_002805	COG4555	ABC transporter
CG475_002825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CG475_002830	COG0735	belongs to the Fur family
CG475_002930	COG3157	Type VI secretion system effector, Hcp
CG475_002950	COG0457	Tetratricopeptide repeat
CG475_002955	COG0217	transcriptional regulatory protein
CG475_002960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CG475_002965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CG475_002985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CG475_002995	COG2766	serine protein kinase
CG475_003020	COG1280	lysine exporter protein (LysE YggA)
CG475_003060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG475_003070	COG1585	Membrane protein implicated in regulation of membrane protease activity
CG475_003075	COG2268	Band 7 protein
CG475_003105	COG4990	cell redox homeostasis
CG475_003115	COG3290	protein histidine kinase activity
CG475_003120	COG4565	transcriptional regulatory protein
CG475_003125	COG3493	citrate carrier protein
CG475_003130	COG0281	malic enzyme
CG475_003145	COG5002	protein histidine kinase activity
CG475_003150	COG0745	RESPONSE REGULATOR receiver
CG475_003160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CG475_003165	COG3383	formate dehydrogenase (NAD+) activity
CG475_003170	COG2427	Protein of unknown function (DUF1641)
CG475_003180	COG0840	transmembrane signaling receptor activity
CG475_003190	COG0531	amino acid
CG475_003205	COG0640	Transcriptional regulator
CG475_003210	COG2217	Heavy metal translocating P-type atpase
CG475_003215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CG475_003225	COG3227	Zinc metalloprotease (Elastase)
CG475_003240	COG2217	Heavy metal translocating P-type atpase
CG475_003260	COG2720	vancomycin resistance protein
CG475_003265	COG1316	TRANSCRIPTIONal
CG475_003275	COG1253	flavin adenine dinucleotide binding
CG475_003280	COG1027	Aspartate ammonia-lyase
CG475_003285	COG1620	l-lactate permease
CG475_003305	COG3104	oligopeptide transport
CG475_003310	COG0156	8-amino-7-oxononanoate synthase activity
CG475_003315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG475_003330	COG4548	von Willebrand factor, type A
CG475_003335	COG0714	Associated with various cellular activities
CG475_003340	COG0531	amino acid
CG475_003345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG475_003350	COG1115	amino acid carrier protein
CG475_003360	COG1126	abc transporter atp-binding protein
CG475_003365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG475_003370	COG0765	amino acid transport
CG475_003375	COG0765	amino acid transport
CG475_003380	COG0833	amino acid
CG475_003390	COG5002	protein histidine kinase activity
CG475_003395	COG0745	RESPONSE REGULATOR receiver
CG475_003405	COG0659	secondary active sulfate transmembrane transporter activity
CG475_003410	COG0589	response to stress
CG475_003420	COG0747	negative chemotaxis
CG475_003430	COG0601	transmembrane transport
CG475_003435	COG4608	Belongs to the ABC transporter superfamily
CG475_003445	COG2271	Major facilitator Superfamily
CG475_003450	COG1846	Transcriptional regulator
CG475_003455	COG0477	Major facilitator Superfamily
CG475_003460	COG1609	Transcriptional regulator
CG475_003465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG475_003470	COG1869	D-ribose catabolic process
CG475_003475	COG1129	ABC transporter
CG475_003480	COG1172	Belongs to the binding-protein-dependent transport system permease family
CG475_003485	COG1879	ABC-type sugar transport system periplasmic component
CG475_003490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CG475_003530	COG3568	Endonuclease Exonuclease Phosphatase
CG475_003555	COG0840	transmembrane signaling receptor activity
CG475_003560	COG3583	domain protein
CG475_003560	COG3584	3D domain protein
CG475_003565	COG1476	TRANSCRIPTIONal
CG475_003595	COG1114	Component of the transport system for branched-chain amino acids
CG475_003605	COG1113	amino acid transport
CG475_003610	COG2153	protein acetylation
CG475_003620	COG0569	domain protein
CG475_003620	COG0475	glutathione-regulated potassium exporter activity
CG475_003635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CG475_003640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CG475_003645	COG0833	amino acid
CG475_003650	COG4990	cell redox homeostasis
CG475_003665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG475_003670	COG0697	spore germination
CG475_003675	COG0531	amino acid
CG475_003690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG475_003695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG475_003700	COG1918	ferrous iron import across plasma membrane
CG475_003700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG475_003705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG475_003710	COG0573	inorganic phosphate transmembrane transporter activity
CG475_003715	COG0581	inorganic phosphate transmembrane transporter activity
CG475_003720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG475_003760	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG475_003845	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CG475_003870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG475_003875	COG1116	anion transmembrane transporter activity
CG475_003880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG475_003885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG475_003890	COG0352	thiamine-phosphate diphosphorylase activity
CG475_003895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG475_003900	COG2104	thiamine diphosphate biosynthetic process
CG475_003905	COG2022	thiamine diphosphate biosynthetic process
CG475_003910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG475_003915	COG0351	phosphomethylpyrimidine kinase
CG475_003945	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CG475_003950	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CG475_003955	COG2205	protein histidine kinase activity
CG475_003965	COG4974	Belongs to the 'phage' integrase family
CG475_003985	COG0735	belongs to the Fur family
CG475_004010	COG1846	Transcriptional regulator
CG475_004020	COG2252	PERMEase
CG475_004025	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_004030	COG1376	ErfK ybiS ycfS ynhG family protein
CG475_004055	COG1316	TRANSCRIPTIONal
CG475_004085	COG0778	Nitroreductase
CG475_004095	COG2719	SpoVR family
CG475_004105	COG1316	TRANSCRIPTIONal
CG475_004110	COG1283	sodium-dependent phosphate transmembrane transporter activity
CG475_004125	COG0577	efflux transmembrane transporter activity
CG475_004130	COG1136	(ABC) transporter
CG475_004140	COG1114	Component of the transport system for branched-chain amino acids
CG475_004145	COG3546	catalase activity
CG475_004200	COG0475	glutathione-regulated potassium exporter activity
CG475_004205	COG1737	Transcriptional regulator
CG475_004215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CG475_004220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG475_004220	COG1263	PTS System
CG475_004265	COG1522	sequence-specific DNA binding
CG475_004280	COG0531	amino acid
CG475_004290	COG1012	belongs to the aldehyde dehydrogenase family
CG475_004295	COG1132	(ABC) transporter
CG475_004300	COG1132	(ABC) transporter
CG475_004310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG475_004315	COG0765	amino acid transport
CG475_004320	COG1126	abc transporter atp-binding protein
CG475_004335	COG0189	ligase activity
CG475_004340	COG4399	Belongs to the UPF0754 family
CG475_004345	COG3679	Belongs to the UPF0342 family
CG475_004350	COG4585	Histidine kinase
CG475_004355	COG2197	response regulator
CG475_004415	COG2094	Belongs to the DNA glycosylase MPG family
CG475_004420	COG0561	phosphatase activity
CG475_004430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG475_004435	COG0318	PFAM AMP-dependent synthetase and ligase
CG475_004460	COG2244	polysaccharide biosynthetic process
CG475_004470	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG475_004490	COG1696	Membrane protein involved in D-alanine export
CG475_004505	COG1024	Enoyl-CoA hydratase
CG475_004520	COG1363	Peptidase, m42
CG475_004535	COG2239	Acts as a magnesium transporter
CG475_004540	COG0772	Belongs to the SEDS family
CG475_004545	COG1115	amino acid carrier protein
CG475_004670	COG1476	TRANSCRIPTIONal
CG475_004715	COG1131	(ABC) transporter
CG475_004760	COG0494	nUDIX hydrolase
CG475_004775	COG1061	Type III restriction enzyme res subunit
CG475_004790	COG4638	Rieske (2fe-2S)
CG475_004795	COG1012	belongs to the aldehyde dehydrogenase family
CG475_004800	COG0473	3-isopropylmalate dehydrogenase activity
CG475_004810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG475_004820	COG1064	alcohol dehydrogenase
CG475_004835	COG3246	L-lysine catabolic process to acetate
CG475_004870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CG475_004880	COG4641	Protein conserved in bacteria
CG475_004895	COG3711	transcriptional antiterminator
CG475_004900	COG1263	PTS System
CG475_004900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG475_004900	COG2190	(PTS) system
CG475_004905	COG2723	6-phospho-beta-galactosidase activity
CG475_004915	COG2376	Dihydroxyacetone kinase
CG475_004920	COG0393	Putative heavy-metal-binding
CG475_004950	COG0420	3'-5' exonuclease activity
CG475_004955	COG4717	serine-type aminopeptidase activity
CG475_004960	COG3481	metal-dependent phosphohydrolase, HD sub domain
CG475_004980	COG1136	(ABC) transporter
CG475_004985	COG5002	protein histidine kinase activity
CG475_004990	COG0745	RESPONSE REGULATOR receiver
CG475_005000	COG1316	TRANSCRIPTIONal
CG475_005015	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CG475_005020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG475_005025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CG475_005030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CG475_005050	COG1846	Transcriptional regulator
CG475_005055	COG4980	gas vesicle protein
CG475_005065	COG0537	adenosine 5'-monophosphoramidase activity
CG475_005070	COG1131	(ABC) transporter
CG475_005075	COG4473	ABC transporter
CG475_005095	COG3402	PFAM membrane-flanked domain
CG475_005105	COG2329	Antibiotic biosynthesis monooxygenase
CG475_005110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG475_005115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CG475_005155	COG1309	transcriptional regulator
CG475_005165	COG1216	Glycosyl transferase, family 2
CG475_005165	COG0438	transferase activity, transferring glycosyl groups
CG475_005175	COG1609	Transcriptional regulator
CG475_005185	COG1234	tRNA 3'-trailer cleavage
CG475_005190	COG0095	Lipoate-protein ligase
CG475_005200	COG0318	PFAM AMP-dependent synthetase and ligase
CG475_005215	COG2205	protein histidine kinase activity
CG475_005220	COG0745	RESPONSE REGULATOR receiver
CG475_005240	COG0501	Belongs to the peptidase M48B family
CG475_005245	COG0840	transmembrane signaling receptor activity
CG475_005250	COG0697	spore germination
CG475_005265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CG475_005270	COG2224	Isocitrate lyase
CG475_005275	COG1278	Cold shock
CG475_005280	COG4903	ComK protein
CG475_005285	COG0398	Pfam SNARE associated Golgi protein
CG475_005295	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CG475_005300	COG1074	ATP-dependent DNA helicase activity
CG475_005340	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG475_005360	COG0367	asparagine synthase
CG475_005370	COG0753	catalase activity
CG475_005380	COG0366	Alpha amylase catalytic
CG475_005380	COG1874	Beta-galactosidase
CG475_005385	COG1666	GTP binding
CG475_005390	COG2996	Protein conserved in bacteria
CG475_005405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG475_005420	COG0561	phosphatase activity
CG475_005445	COG2267	carboxylic ester hydrolase activity
CG475_005460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG475_005465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CG475_005470	COG5504	Zn-dependent protease
CG475_005480	COG0180	Tryptophanyl-tRNA synthetase
CG475_005495	COG4166	transmembrane transport
CG475_005500	COG0601	transmembrane transport
CG475_005505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG475_005510	COG0444	Belongs to the ABC transporter superfamily
CG475_005515	COG4608	Belongs to the ABC transporter superfamily
CG475_005520	COG0534	Mate efflux family protein
CG475_005525	COG4166	transmembrane transport
CG475_005545	COG1393	Belongs to the ArsC family
CG475_005550	COG0861	Integral membrane protein TerC family
CG475_005570	COG1164	Oligoendopeptidase f
CG475_005585	COG2346	COG2346, Truncated hemoglobins
CG475_005590	COG4116	CYTH
CG475_005600	COG2357	RelA SpoT domain protein
CG475_005610	COG0564	pseudouridine synthase activity
CG475_005620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG475_005625	COG0772	Belongs to the SEDS family
CG475_005670	COG1216	Glycosyl transferase, family 2
CG475_005690	COG0463	Glycosyl transferase, family 2
CG475_005690	COG0457	Tetratricopeptide repeat
CG475_005710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CG475_005725	COG1091	dTDP-4-dehydrorhamnose reductase activity
CG475_005750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CG475_005755	COG2382	esterase
CG475_005770	COG5492	domain, Protein
CG475_005775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG475_005790	COG1620	l-lactate permease
CG475_005795	COG5634	Uncharacterized conserved protein (DUF2278)
CG475_005835	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG475_005840	COG0567	Dehydrogenase, E1 component
CG475_005850	COG0583	DNA-binding transcription factor activity
CG475_005855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG475_005860	COG1012	belongs to the aldehyde dehydrogenase family
CG475_005875	COG0196	riboflavin kinase activity
CG475_005880	COG3162	membrane
CG475_005885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG475_005890	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG475_005905	COG0457	Tetratricopeptide repeat
CG475_005970	COG0673	inositol 2-dehydrogenase activity
CG475_006000	COG0457	Tetratricopeptide repeat
CG475_006005	COG0582	viral genome integration into host DNA
CG475_006055	COG0582	viral genome integration into host DNA
CG475_006080	COG1686	Belongs to the peptidase S11 family
CG475_006085	COG0681	Belongs to the peptidase S26 family
CG475_006120	COG1012	belongs to the aldehyde dehydrogenase family
CG475_006130	COG1176	ABC-type spermidine putrescine transport system, permease component I
CG475_006135	COG1177	transmembrane transport
CG475_006140	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CG475_006145	COG0671	phosphoesterase, PA-phosphatase related
CG475_006150	COG2409	Drug exporters of the RND superfamily
CG475_006160	COG0564	pseudouridine synthase activity
CG475_006170	COG2340	Cysteine-rich secretory protein family
CG475_006175	COG0247	lactate metabolic process
CG475_006180	COG0277	FAD linked oxidase domain protein
CG475_006185	COG3835	regulator
CG475_006195	COG0745	RESPONSE REGULATOR receiver
CG475_006200	COG5002	protein histidine kinase activity
CG475_006205	COG2186	Transcriptional regulator
CG475_006210	COG0247	lactate metabolic process
CG475_006215	COG1139	Iron-sulfur cluster binding protein
CG475_006220	COG1556	Lactate utilization protein
CG475_006225	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CG475_006230	COG0584	glycerophosphoryl diester phosphodiesterase
CG475_006245	COG2267	carboxylic ester hydrolase activity
CG475_006250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG475_006280	COG2116	formate transmembrane transporter activity
CG475_006285	COG0861	Integral membrane protein TerC family
CG475_006290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG475_006300	COG2030	dehydratase
CG475_006320	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_006325	COG3243	poly(R)-hydroxyalkanoic acid synthase
CG475_006330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG475_006345	COG1840	ABC-type Fe3 transport system, periplasmic component
CG475_006350	COG3842	ATPase activity
CG475_006360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG475_006365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CG475_006370	COG1349	DNA-binding transcription factor activity
CG475_006375	COG0235	Class ii aldolase
CG475_006385	COG2861	carbohydrate metabolic process
CG475_006395	COG3852	Histidine kinase
CG475_006400	COG1846	Transcriptional regulator
CG475_006420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CG475_006425	COG0720	synthase
CG475_006435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CG475_006440	COG4873	Protein conserved in bacteria
CG475_006450	COG0456	acetyltransferase
CG475_006470	COG1780	Probably involved in ribonucleotide reductase function
CG475_006485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CG475_006490	COG1725	Transcriptional regulator
CG475_006495	COG1131	(ABC) transporter
CG475_006505	COG1131	(ABC) transporter
CG475_006510	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG475_006525	COG1522	sequence-specific DNA binding
CG475_006540	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG475_006545	COG2070	2-Nitropropane dioxygenase
CG475_006550	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CG475_006560	COG1696	Membrane protein involved in D-alanine export
CG475_006565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG475_006580	COG0716	FMN binding
CG475_006605	COG1368	sulfuric ester hydrolase activity
CG475_006615	COG3173	Aminoglycoside phosphotransferase
CG475_006630	COG5609	conserved protein (DUF2294)
CG475_006635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG475_006640	COG3002	Belongs to the UPF0753 family
CG475_006645	COG0288	reversible hydration of carbon dioxide
CG475_006650	COG0534	Mate efflux family protein
CG475_006665	COG1846	Transcriptional regulator
CG475_006675	COG1301	dicarboxylic acid transport
CG475_006680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG475_006690	COG3874	Sporulation protein YtfJ
CG475_006715	COG0028	Belongs to the TPP enzyme family
CG475_006720	COG0440	acetolactate synthase activity
CG475_006725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CG475_006730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG475_006740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CG475_006745	COG0066	3-isopropylmalate dehydratase activity
CG475_006755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CG475_006765	COG0131	Imidazoleglycerol-phosphate dehydratase
CG475_006770	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CG475_006775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CG475_006780	COG0107	imidazoleglycerol-phosphate synthase activity
CG475_006785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CG475_006790	COG0140	phosphoribosyl-ATP diphosphatase activity
CG475_006805	COG1183	phosphatidylcholine synthase activity
CG475_006810	COG1368	sulfuric ester hydrolase activity
CG475_006820	COG0019	diaminopimelate decarboxylase activity
CG475_006830	COG0175	sulfate reduction
CG475_006835	COG2046	Belongs to the sulfate adenylyltransferase family
CG475_006840	COG0529	Catalyzes the synthesis of activated sulfate
CG475_006845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG475_006865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG475_006865	COG1648	precorrin-2 dehydrogenase activity
CG475_006870	COG0733	neurotransmitter:sodium symporter activity
CG475_006885	COG3557	Belongs to the UPF0374 family
CG475_006890	COG1757	Na H antiporter
CG475_006905	COG4758	membrane
CG475_006910	COG4585	Histidine kinase
CG475_006915	COG2197	response regulator
CG475_006920	COG1114	Component of the transport system for branched-chain amino acids
CG475_006925	COG0737	Belongs to the 5'-nucleotidase family
CG475_006925	COG1525	nuclease
CG475_006925	COG4085	toxin activity
CG475_006965	COG2723	6-phospho-beta-galactosidase activity
CG475_006980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG475_006980	COG3711	transcriptional antiterminator
CG475_006985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG475_006985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG475_006985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG475_006990	COG1482	cell wall glycoprotein biosynthetic process
CG475_007000	COG2801	Transposase and inactivated derivatives
CG475_007020	COG0730	response to heat
CG475_007025	COG0306	phosphate transporter
CG475_007030	COG1392	Phosphate transport regulator
CG475_007035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG475_007045	COG3852	Histidine kinase
CG475_007050	COG1801	Protein of unknown function DUF72
CG475_007060	COG0582	viral genome integration into host DNA
CG475_007065	COG5002	protein histidine kinase activity
CG475_007070	COG0813	purine-nucleoside phosphorylase activity
CG475_007080	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CG475_007080	COG0392	lysyltransferase activity
CG475_007095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG475_007100	COG1686	Belongs to the peptidase S11 family
CG475_007105	COG2715	membrane protein required for spore maturation
CG475_007110	COG0700	Nucleoside recognition
CG475_007115	COG1187	pseudouridine synthase activity
CG475_007125	COG1333	cytochrome c biogenesis protein
CG475_007130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG475_007135	COG0745	RESPONSE REGULATOR receiver
CG475_007140	COG5002	protein histidine kinase activity
CG475_007145	COG2096	Adenosyltransferase
CG475_007160	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CG475_007165	COG1141	Ferredoxin
CG475_007175	COG0514	ATP-dependent DNA helicase (RecQ)
CG475_007180	COG1266	CAAX protease self-immunity
CG475_007190	COG1408	metallophosphoesterase
CG475_007205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG475_007220	COG0492	ferredoxin-NADP+ reductase activity
CG475_007235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CG475_007245	COG1304	FMN binding
CG475_007270	COG1160	GTP binding
CG475_007275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CG475_007295	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG475_007305	COG0302	gtp cyclohydrolase
CG475_007310	COG0142	geranyltranstransferase activity
CG475_007315	COG2226	methyltransferase
CG475_007320	COG0142	geranyltranstransferase activity
CG475_007325	COG0105	UTP biosynthetic process
CG475_007330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CG475_007335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CG475_007340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CG475_007345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CG475_007350	COG0457	Tetratricopeptide repeat
CG475_007355	COG5582	Belongs to the UPF0302 family
CG475_007370	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CG475_007380	COG4347	Protein of unknown function (DUF1405)
CG475_007395	COG2738	Putative neutral zinc metallopeptidase
CG475_007405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG475_007410	COG1694	Mazg nucleotide pyrophosphohydrolase
CG475_007415	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CG475_007420	COG1803	Methylglyoxal synthase
CG475_007425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG475_007430	COG0438	transferase activity, transferring glycosyl groups
CG475_007435	COG0617	tRNA 3'-terminal CCA addition
CG475_007450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CG475_007455	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CG475_007460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CG475_007465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CG475_007465	COG1199	ATP-dependent helicase activity
CG475_007485	COG3935	DnaD domain protein
CG475_007490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CG475_007500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG475_007500	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG475_007505	COG3331	DNA recombination
CG475_007540	COG4474	Belongs to the UPF0398 family
CG475_007545	COG3599	regulation of cell shape
CG475_007555	COG0116	Belongs to the methyltransferase superfamily
CG475_007565	COG1199	ATP-dependent helicase activity
CG475_007570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CG475_007575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG475_007580	COG2233	PERMEase
CG475_007585	COG2311	Membrane
CG475_007590	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG475_007600	COG0456	acetyltransferase
CG475_007640	COG3766	membrane
CG475_007645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG475_007650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG475_007655	COG1733	regulation of RNA biosynthetic process
CG475_007675	COG0328	RNA-DNA hybrid ribonuclease activity
CG475_007705	COG1278	Cold shock
CG475_007715	COG3162	membrane
CG475_007720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG475_007725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG475_007730	COG0475	glutathione-regulated potassium exporter activity
CG475_007735	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG475_007760	COG2323	membrane
CG475_007765	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CG475_007790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG475_007800	COG2201	protein-glutamate methylesterase activity
CG475_007805	COG2198	Histidine kinase
CG475_007805	COG0643	Histidine kinase
CG475_007810	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG475_007810	COG1776	CheC inhibitor of MCP methylation
CG475_007825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CG475_007845	COG1256	bacterial-type flagellum assembly
CG475_007850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG475_007855	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CG475_007870	COG1815	bacterial-type flagellum-dependent cell motility
CG475_007875	COG1558	bacterial-type flagellum-dependent cell motility
CG475_007880	COG1677	Flagellar hook-basal body complex protein FliE
CG475_007890	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG475_007900	COG1157	protein secretion by the type III secretion system
CG475_007935	COG0835	chemotaxis
CG475_007935	COG0784	Response regulator, receiver
CG475_007945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG475_007950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG475_007955	COG0741	lytic transglycosylase activity
CG475_007965	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG475_007970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG475_007970	COG1776	CheC inhibitor of MCP methylation
CG475_007980	COG1338	Plays a role in the flagellum-specific transport system
CG475_007985	COG1987	bacterial-type flagellum assembly
CG475_007995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG475_008000	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG475_008005	COG1419	protein localization to endoplasmic reticulum
CG475_008010	COG4786	Flagellar basal body rod
CG475_008015	COG1136	(ABC) transporter
CG475_008015	COG0577	efflux transmembrane transporter activity
CG475_008065	COG2814	Major facilitator Superfamily
CG475_008075	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_008110	COG0367	asparagine synthase
CG475_008130	COG1802	Transcriptional regulator
CG475_008135	COG0697	spore germination
CG475_008145	COG1757	Na H antiporter
CG475_008155	COG0114	fumarate hydratase activity
CG475_008180	COG0534	Mate efflux family protein
CG475_008185	COG3340	Belongs to the peptidase S51 family
CG475_008190	COG2733	membrane
CG475_008200	COG1280	lysine exporter protein (LysE YggA)
CG475_008205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG475_008220	COG2502	aspartate--ammonia ligase
CG475_008230	COG0109	protoheme IX farnesyltransferase activity
CG475_008260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG475_008270	COG4166	transmembrane transport
CG475_008275	COG2223	nitrite transmembrane transporter activity
CG475_008280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG475_008285	COG2244	polysaccharide biosynthetic process
CG475_008290	COG0733	neurotransmitter:sodium symporter activity
CG475_008295	COG5566	PFAM Mor transcription activator
CG475_008310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG475_008315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG475_008325	COG0129	dihydroxy-acid dehydratase activity
CG475_008330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CG475_008360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG475_008365	COG2814	Major facilitator Superfamily
CG475_008370	COG3384	dioxygenase
CG475_008390	COG0402	S-adenosylhomocysteine deaminase activity
CG475_008395	COG4166	transmembrane transport
CG475_008405	COG1914	H( )-stimulated, divalent metal cation uptake system
CG475_008420	COG0083	homoserine kinase activity
CG475_008430	COG2390	Transcriptional regulator
CG475_008435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CG475_008460	COG1510	regulation of RNA biosynthetic process
CG475_008470	COG1454	alcohol dehydrogenase
CG475_008485	COG1012	belongs to the aldehyde dehydrogenase family
CG475_008500	COG0628	permease
CG475_008505	COG0039	L-malate dehydrogenase activity
CG475_008510	COG0523	cobalamin synthesis protein
CG475_008535	COG1686	Belongs to the peptidase S11 family
CG475_008550	COG0791	NLP P60 protein
CG475_008550	COG1388	LysM domain
CG475_008555	COG0300	oxidoreductase activity
CG475_008565	COG0460	homoserine dehydrogenase
CG475_008575	COG0083	homoserine kinase activity
CG475_008580	COG1316	TRANSCRIPTIONal
CG475_008585	COG0726	polysaccharide deacetylase
CG475_008595	COG1285	pathogenesis
CG475_008600	COG1247	-acetyltransferase
CG475_008615	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG475_008635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CG475_008640	COG0577	efflux transmembrane transporter activity
CG475_008645	COG2409	Drug exporters of the RND superfamily
CG475_008650	COG1404	Belongs to the peptidase S8 family
CG475_008665	COG0840	transmembrane signaling receptor activity
CG475_008680	COG3949	Membrane
CG475_008685	COG0783	Belongs to the Dps family
CG475_008705	COG0523	cobalamin synthesis protein
CG475_008715	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG475_008730	COG1902	pentaerythritol trinitrate reductase activity
CG475_008735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CG475_008745	COG4166	transmembrane transport
CG475_008750	COG0346	lactoylglutathione lyase activity
CG475_008760	COG5337	Spore coat protein CotH
CG475_008765	COG1051	belongs to the nudix hydrolase family
CG475_008770	COG0586	Pfam SNARE associated Golgi protein
CG475_008775	COG2244	polysaccharide biosynthetic process
CG475_008785	COG0701	Predicted permease
CG475_008790	COG3689	TIGRFAM TIGR03943 family protein
CG475_008795	COG1607	acyl-coa hydrolase
CG475_008805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG475_008815	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_008825	COG2839	Protein conserved in bacteria
CG475_008830	COG1253	flavin adenine dinucleotide binding
CG475_008845	COG1114	Component of the transport system for branched-chain amino acids
CG475_008870	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG475_008880	COG1876	peptidase activity
CG475_008930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CG475_008935	COG1819	glycosyl
CG475_008940	COG1819	glycosyl
CG475_008945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG475_008995	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG475_009050	COG3874	Sporulation protein YtfJ
CG475_009075	COG2226	methyltransferase
CG475_009100	COG0386	Belongs to the glutathione peroxidase family
CG475_009135	COG0640	Transcriptional regulator
CG475_009140	COG0798	PFAM Bile acid sodium symporter
CG475_009145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG475_009190	COG1418	mRNA catabolic process
CG475_009195	COG0488	(ABC) transporter
CG475_009205	COG0629	single-stranded DNA binding
CG475_009210	COG1413	lyase activity
CG475_009225	COG2521	methyltransferase
CG475_009225	COG2136	Putative SAM-dependent methyltransferase
CG475_009230	COG0018	arginyl-trna synthetase
CG475_009240	COG0733	neurotransmitter:sodium symporter activity
CG475_009265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG475_009270	COG0477	Major facilitator Superfamily
CG475_009290	COG2610	gluconate transmembrane transporter activity
CG475_009300	COG0456	acetyltransferase
CG475_009305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CG475_009315	COG1131	(ABC) transporter
CG475_009320	COG4473	ABC transporter
CG475_009335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG475_009340	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CG475_009350	COG0768	penicillin binding
CG475_009360	COG0204	Acyl-transferase
CG475_009365	COG1272	protein, Hemolysin III
CG475_009370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CG475_009375	COG0805	protein transport
CG475_009385	COG1307	EDD domain protein, DegV family
CG475_009395	COG1999	signal sequence binding
CG475_009400	COG0071	Belongs to the small heat shock protein (HSP20) family
CG475_009405	COG0367	asparagine synthase
CG475_009420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG475_009440	COG0071	Belongs to the small heat shock protein (HSP20) family
CG475_009450	COG1737	Transcriptional regulator
CG475_009455	COG1070	Carbohydrate kinase
CG475_009465	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CG475_009520	COG1151	hydroxylamine reductase activity
CG475_009530	COG1253	flavin adenine dinucleotide binding
CG475_009535	COG5506	Protein of unknown function (DUF1694)
CG475_009555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG475_009560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CG475_009565	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CG475_009570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG475_009580	COG3829	transcription factor binding
CG475_009590	COG1509	lysine 2,3-aminomutase activity
CG475_009600	COG4479	Belongs to the UPF0346 family
CG475_009625	COG0515	serine threonine protein kinase
CG475_009625	COG1357	PFAM Pentapeptide repeats (8 copies)
CG475_009630	COG0671	phosphoesterase, PA-phosphatase related
CG475_009635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG475_009640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG475_009685	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CG475_009695	COG0726	polysaccharide deacetylase
CG475_009700	COG1408	metallophosphoesterase
CG475_009705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG475_009710	COG2323	membrane
CG475_009715	COG0671	phosphoesterase, PA-phosphatase related
CG475_009725	COG1280	lysine exporter protein (LysE YggA)
CG475_009730	COG3403	YqcI/YcgG family
CG475_009760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG475_009760	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG475_009770	COG0372	Belongs to the citrate synthase family
CG475_009775	COG2079	MmgE PrpD family protein
CG475_009780	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CG475_009785	COG1960	acyl-CoA dehydrogenase activity
CG475_009790	COG2084	Dehydrogenase
CG475_009795	COG1012	belongs to the aldehyde dehydrogenase family
CG475_009805	COG1280	lysine exporter protein (LysE YggA)
CG475_009825	COG0420	3'-5' exonuclease activity
CG475_009830	COG0419	ATPase involved in DNA repair
CG475_009835	COG3104	oligopeptide transport
CG475_009865	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG475_009870	COG1131	(ABC) transporter
CG475_009890	COG1131	(ABC) transporter
CG475_009895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG475_009915	COG1942	4-Oxalocrotonate Tautomerase
CG475_009950	COG0457	Tetratricopeptide repeat
CG475_009985	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_009990	COG1169	isochorismate synthase
CG475_010000	COG3433	isochorismatase activity
CG475_010000	COG1535	isochorismatase
CG475_010005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG475_010010	COG3251	PFAM MbtH domain protein
CG475_010015	COG2814	Major facilitator Superfamily
CG475_010030	COG0776	regulation of translation
CG475_010045	COG2329	Antibiotic biosynthesis monooxygenase
CG475_010050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG475_010085	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG475_010095	COG0667	Aldo Keto reductase
CG475_010115	COG0010	Belongs to the arginase family
CG475_010125	COG1132	(ABC) transporter
CG475_010130	COG1132	(ABC) transporter
CG475_010135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG475_010160	COG1649	PFAM Uncharacterised BCR, COG1649
CG475_010180	COG2971	BadF BadG BcrA BcrD
CG475_010200	COG0588	phosphoglycerate mutase activity
CG475_010230	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG475_010240	COG1960	acyl-CoA dehydrogenase activity
CG475_010245	COG0439	Biotin carboxylase
CG475_010250	COG0511	ligase activity, forming carbon-carbon bonds
CG475_010255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG475_010260	COG1024	Enoyl-CoA hydratase
CG475_010265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CG475_010270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG475_010280	COG1216	Glycosyl transferase, family 2
CG475_010285	COG0640	Transcriptional regulator
CG475_010295	COG1686	Belongs to the peptidase S11 family
CG475_010300	COG5002	protein histidine kinase activity
CG475_010330	COG0789	Transcriptional regulator
CG475_010350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG475_010360	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_010380	COG0475	glutathione-regulated potassium exporter activity
CG475_010400	COG1309	transcriptional regulator
CG475_010410	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_010415	COG2002	toxin-antitoxin pair type II binding
CG475_010420	COG3773	Cell wall hydrolase
CG475_010420	COG3409	Peptidoglycan-binding domain 1 protein
CG475_010435	COG0693	protein deglycase activity
CG475_010440	COG0201	protein transport
CG475_010460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG475_010465	COG0322	excinuclease ABC activity
CG475_010480	COG4667	esterase of the alpha-beta hydrolase superfamily
CG475_010500	COG1051	belongs to the nudix hydrolase family
CG475_010550	COG2223	nitrite transmembrane transporter activity
CG475_010600	COG1216	Glycosyl transferase, family 2
CG475_010615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG475_010620	COG1279	arginine transmembrane transporter activity
CG475_010660	COG1794	racemase activity, acting on amino acids and derivatives
CG475_010670	COG2828	Protein conserved in bacteria
CG475_010675	COG5002	protein histidine kinase activity
CG475_010680	COG0561	phosphatase activity
CG475_010700	COG2124	cytochrome p450
CG475_010735	COG0457	Tetratricopeptide repeat
CG475_010745	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG475_010775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG475_010780	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG475_010790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG475_010800	COG2959	enzyme of heme biosynthesis
CG475_010805	COG3409	Peptidoglycan-binding domain 1 protein
CG475_010805	COG3773	Cell wall hydrolase
CG475_010830	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CG475_010835	COG3844	kynureninase activity
CG475_010845	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_010855	COG4176	ABC-type proline glycine betaine transport system permease component
CG475_010860	COG0517	IMP dehydrogenase activity
CG475_010860	COG4175	Glycine betaine
CG475_010890	COG2153	protein acetylation
CG475_010920	COG0514	ATP-dependent DNA helicase (RecQ)
CG475_010940	COG4637	Psort location Cytoplasmic, score
CG475_010945	COG1227	inorganic diphosphatase activity
CG475_010955	COG3397	chitin binding
CG475_010995	COG4166	transmembrane transport
CG475_011005	COG4948	Mandelate Racemase Muconate Lactonizing
CG475_011085	COG1307	EDD domain protein, DegV family
CG475_011135	COG5444	nuclease activity
CG475_011245	COG5444	nuclease activity
CG475_011265	COG2261	transglycosylase associated protein
CG475_011270	COG0675	Transposase, IS605 OrfB family
CG475_011295	COG0436	Aminotransferase
CG475_011310	COG3973	AAA domain
CG475_011315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG475_011340	COG0628	permease
CG475_011355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG475_011360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG475_011365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG475_011380	COG2746	aminoglycoside 3-N-acetyltransferase activity
CG475_011395	COG0454	-acetyltransferase
CG475_011395	COG0456	acetyltransferase
CG475_011405	COG0726	polysaccharide deacetylase
CG475_011410	COG3037	sugar-specific permease SgaT UlaA
CG475_011420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG475_011425	COG1368	sulfuric ester hydrolase activity
CG475_011430	COG0488	(ABC) transporter
CG475_011435	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG475_011435	COG1605	Chorismate mutase
CG475_011455	COG0346	lactoylglutathione lyase activity
CG475_011465	COG3547	Transposase (IS116 IS110 IS902 family)
CG475_011470	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG475_011510	COG2329	Antibiotic biosynthesis monooxygenase
CG475_011525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG475_011550	COG0494	nUDIX hydrolase
CG475_011565	COG0456	acetyltransferase
CG475_011570	COG0477	Major facilitator Superfamily
CG475_011585	COG0697	spore germination
CG475_011590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG475_011600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG475_011615	COG0730	response to heat
CG475_011625	COG0833	amino acid
CG475_011650	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CG475_011665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CG475_011670	COG1984	allophanate hydrolase subunit 2
CG475_011675	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CG475_011680	COG1414	Transcriptional regulator
CG475_011695	COG1960	acyl-CoA dehydrogenase activity
CG475_011725	COG0346	lactoylglutathione lyase activity
CG475_011735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG475_011740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CG475_011745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG475_011750	COG0438	transferase activity, transferring glycosyl groups
CG475_011765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG475_011770	COG0438	transferase activity, transferring glycosyl groups
CG475_011775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG475_011785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CG475_011805	COG4851	CamS sex pheromone cAM373 precursor
CG475_011925	COG0477	Major facilitator Superfamily
CG475_011940	COG1846	Transcriptional regulator
CG475_011945	COG2814	Major facilitator Superfamily
CG475_011955	COG2031	fatty acid transporter
CG475_011990	COG1122	ATPase activity
CG475_012015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CG475_012030	COG1131	(ABC) transporter
CG475_012090	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CG475_012095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG475_012100	COG0579	oxidoreductase
CG475_012105	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CG475_012115	COG1253	flavin adenine dinucleotide binding
CG475_012120	COG0789	Transcriptional regulator
CG475_012125	COG3813	Protein conserved in bacteria
CG475_012205	COG0582	viral genome integration into host DNA
CG475_012245	COG4591	ABC-type transport system involved in lipoprotein release permease component
CG475_012250	COG1136	(ABC) transporter
CG475_012250	COG0577	efflux transmembrane transporter activity
CG475_012315	COG2072	flavoprotein involved in K transport
CG475_012340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG475_012345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG475_012365	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CG475_012370	COG1164	Oligoendopeptidase f
CG475_012390	COG0584	glycerophosphoryl diester phosphodiesterase
CG475_012395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG475_012425	COG3397	chitin binding
CG475_012435	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CG475_012440	COG0277	FAD linked oxidase domain protein
CG475_012445	COG1285	pathogenesis
CG475_012450	COG2720	vancomycin resistance protein
CG475_012650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CG475_012755	COG1484	DNA-dependent DNA replication
CG475_012805	COG0582	viral genome integration into host DNA
CG475_012830	COG1278	Cold shock
CG475_012840	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_012845	COG0165	Argininosuccinate lyase
CG475_012860	COG3409	Peptidoglycan-binding domain 1 protein
CG475_012875	COG4145	pantothenate transmembrane transporter activity
CG475_012880	COG3924	membrane
CG475_012885	COG1012	belongs to the aldehyde dehydrogenase family
CG475_012895	COG1657	PFAM Prenyltransferase squalene oxidase
CG475_012900	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CG475_012905	COG2962	Rard protein
CG475_012940	COG2226	methyltransferase
CG475_012945	COG4166	transmembrane transport
CG475_012950	COG4166	transmembrane transport
CG475_012955	COG1301	dicarboxylic acid transport
CG475_012960	COG0673	inositol 2-dehydrogenase activity
CG475_012965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG475_012970	COG0187	DNA topoisomerase II activity
CG475_012980	COG1832	CoA-binding protein
CG475_012985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG475_012990	COG0745	RESPONSE REGULATOR receiver
CG475_013005	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CG475_013010	COG4841	protein insertion into membrane
CG475_013020	COG0824	Thioesterase
CG475_013050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG475_013055	COG3655	Transcriptional regulator
CG475_013075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CG475_013085	COG0726	polysaccharide deacetylase
CG475_013115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG475_013120	COG0318	PFAM AMP-dependent synthetase and ligase
CG475_013150	COG0457	Tetratricopeptide repeat
CG475_013225	COG2826	transposase and inactivated derivatives, IS30 family
CG475_013240	COG0534	Mate efflux family protein
CG475_013270	COG3023	N-Acetylmuramoyl-L-alanine amidase
CG475_013280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG475_013290	COG5002	protein histidine kinase activity
CG475_013295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG475_013300	COG0010	Belongs to the arginase family
CG475_013305	COG1228	amidohydrolase
CG475_013310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CG475_013315	COG2986	histidine ammonia-lyase
CG475_013335	COG4846	Membrane protein involved in cytochrome C biogenesis
CG475_013340	COG0785	Cytochrome C biogenesis protein
CG475_013355	COG0583	DNA-binding transcription factor activity
CG475_013360	COG1380	Effector of murein hydrolase LrgA
CG475_013365	COG1346	cytolysis
CG475_013370	COG4187	Peptidase family M20/M25/M40
CG475_013380	COG0833	amino acid
CG475_013390	COG0730	response to heat
CG475_013400	COG3409	Peptidoglycan-binding domain 1 protein
CG475_013400	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG475_013415	COG1132	(ABC) transporter
CG475_013420	COG1132	(ABC) transporter
CG475_013425	COG3763	UPF0154 protein
CG475_013440	COG3639	organic phosphonate transmembrane transporter activity
CG475_013445	COG3639	organic phosphonate transmembrane transporter activity
CG475_013460	COG0737	Belongs to the 5'-nucleotidase family
CG475_013465	COG4224	UPF0291 protein
CG475_013470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG475_013475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CG475_013490	COG1695	Transcriptional regulator
CG475_013525	COG3328	transposase activity
CG475_013530	COG3328	transposase activity
CG475_013535	COG3328	transposase activity
CG475_013550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG475_013575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG475_013595	COG0730	response to heat
CG475_013650	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG475_013720	COG3723	Recombinational DNA repair protein, rece pathway
CG475_013765	COG0582	viral genome integration into host DNA
CG475_013770	COG0174	glutamine synthetase
CG475_013775	COG0789	Transcriptional regulator
CG475_013780	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CG475_013785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG475_013790	COG2860	membrane
CG475_013795	COG0464	growth
CG475_013810	COG1923	regulation of RNA biosynthetic process
CG475_013815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CG475_013825	COG3584	3D domain protein
CG475_013825	COG1388	LysM domain
CG475_013830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG475_013830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG475_013830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG475_013835	COG1105	Belongs to the carbohydrate kinase PfkB family
CG475_013840	COG1349	DNA-binding transcription factor activity
CG475_013845	COG2322	membrane
CG475_013870	COG2116	formate transmembrane transporter activity
CG475_013880	COG1937	Protein conserved in bacteria
CG475_013885	COG2819	hydrolase of the alpha beta superfamily
CG475_013890	COG1120	ATPase activity
CG475_013895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG475_013900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG475_013905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG475_013910	COG2706	6-phosphogluconolactonase activity
CG475_013915	COG2826	transposase and inactivated derivatives, IS30 family
CG475_013920	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG475_013930	COG0346	lactoylglutathione lyase activity
CG475_013945	COG1113	amino acid transport
CG475_013970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CG475_013975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CG475_013985	COG4550	Control of competence regulator ComK, YlbF/YmcA
CG475_013990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG475_013995	COG1013	pyruvate-flavodoxin oxidoreductase activity
CG475_014000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CG475_014000	COG0674	pyruvate-flavodoxin oxidoreductase activity
CG475_014010	COG2359	stage V sporulation protein S
CG475_014015	COG1692	metallophosphoesterase
CG475_014020	COG1418	mRNA catabolic process
CG475_014025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CG475_014030	COG1546	Belongs to the CinA family
CG475_014030	COG1058	Belongs to the CinA family
CG475_014035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG475_014040	COG1426	Protein conserved in bacteria
CG475_014055	COG0300	oxidoreductase activity
CG475_014060	COG0612	Peptidase, M16
CG475_014065	COG0612	Peptidase, M16
CG475_014090	COG2188	Transcriptional regulator
CG475_014110	COG0740	serine-type endopeptidase activity
CG475_014135	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG475_014150	COG0527	aspartate kinase activity
CG475_014155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CG475_014160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG475_014165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG475_014170	COG1873	PFAM PRC-barrel domain
CG475_014175	COG0612	Peptidase, M16
CG475_014180	COG0726	polysaccharide deacetylase
CG475_014185	COG1185	polyribonucleotide nucleotidyltransferase activity
CG475_014195	COG0196	riboflavin kinase activity
CG475_014200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CG475_014205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CG475_014210	COG1550	Protein conserved in bacteria
CG475_014215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CG475_014220	COG1358	cellular component organization or biogenesis
CG475_014225	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CG475_014230	COG0195	Participates in both transcription termination and antitermination
CG475_014235	COG0779	Required for maturation of 30S ribosomal subunits
CG475_014245	COG0442	prolyl-tRNA aminoacylation
CG475_014250	COG0750	zinc metalloprotease
CG475_014260	COG4589	Belongs to the CDS family
CG475_014270	COG0233	cytoplasmic translational termination
CG475_014275	COG0528	UMP kinase activity
CG475_014280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CG475_014285	COG0052	Belongs to the universal ribosomal protein uS2 family
CG475_014290	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CG475_014295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CG475_014300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CG475_014305	COG4974	Belongs to the 'phage' integrase family
CG475_014310	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CG475_014315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG475_014320	COG0758	DNA mediated transformation
CG475_014325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CG475_014330	COG0045	succinate-CoA ligase (ADP-forming) activity
CG475_014335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG475_014350	COG0335	large ribosomal subunit rRNA binding
CG475_014360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CG475_014365	COG1837	Belongs to the UPF0109 family
CG475_014370	COG0228	four-way junction DNA binding
CG475_014375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CG475_014380	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CG475_014385	COG0552	protein localization to endoplasmic reticulum
CG475_014390	COG1196	nuclear chromosome segregation
CG475_014395	COG0571	ribonuclease III activity
CG475_014405	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_014410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CG475_014415	COG0416	fatty acid biosynthetic process
CG475_014420	COG1349	DNA-binding transcription factor activity
CG475_014420	COG2050	protein possibly involved in aromatic compounds catabolism
CG475_014425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CG475_014430	COG1461	Dihydroxyacetone kinase
CG475_014435	COG1302	Protein conserved in bacteria
CG475_014440	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CG475_014450	COG1564	THIamine pyrophosphokinase
CG475_014455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CG475_014460	COG1162	GTPase activity
CG475_014465	COG0515	serine threonine protein kinase
CG475_014465	COG2815	serine threonine protein kinase
CG475_014470	COG0631	protein serine/threonine phosphatase activity
CG475_014475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CG475_014480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CG475_014480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG475_014485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG475_014490	COG0242	peptide deformylase activity
CG475_014495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CG475_014500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG475_014505	COG1758	RNA polymerase activity
CG475_014510	COG0194	GDP metabolic process
CG475_014520	COG1561	YicC-like family, N-terminal region
CG475_014525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG475_014550	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CG475_014555	COG0284	orotidine-5'-phosphate decarboxylase activity
CG475_014560	COG0167	dihydroorotate dehydrogenase activity
CG475_014565	COG0543	2 iron, 2 sulfur cluster binding
CG475_014570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CG475_014580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CG475_014585	COG0540	Belongs to the ATCase OTCase family
CG475_014595	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CG475_014605	COG0564	pseudouridine synthase activity
CG475_014610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CG475_014620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CG475_014625	COG3599	regulation of cell shape
CG475_014630	COG2302	S4 RNA-binding domain
CG475_014635	COG0762	integral membrane protein
CG475_014640	COG1799	cell septum assembly
CG475_014645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CG475_014655	COG1873	PFAM PRC-barrel domain
CG475_014660	COG1191	sigma factor activity
CG475_014665	COG1191	sigma factor activity
CG475_014675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CG475_014680	COG0849	cell division
CG475_014685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CG475_014695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG475_014700	COG0772	Belongs to the SEDS family
CG475_014705	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CG475_014710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG475_014715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CG475_014720	COG0768	penicillin binding
CG475_014730	COG4839	cell division protein FtsL
CG475_014735	COG0275	rRNA processing
CG475_014740	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CG475_014745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CG475_014765	COG1399	metal-binding, possibly nucleic acid-binding protein
CG475_014875	COG1802	Transcriptional regulator
CG475_014875	COG4626	Terminase
CG475_014965	COG0756	dUTP diphosphatase activity
CG475_014995	COG3723	Recombinational DNA repair protein, rece pathway
CG475_015005	COG5377	YqaJ viral recombinase family
CG475_015050	COG0582	viral genome integration into host DNA
CG475_015055	COG1323	Belongs to the UPF0348 family
CG475_015060	COG3480	Lon protease (S16) C-terminal proteolytic domain
CG475_015065	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG475_015070	COG3314	Sporulation integral membrane protein YlbJ
CG475_015075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CG475_015080	COG0742	ribosomal rna small subunit methyltransferase
CG475_015090	COG4471	UPF0298 protein
CG475_015095	COG3679	Belongs to the UPF0342 family
CG475_015100	COG0406	alpha-ribazole phosphatase activity
CG475_015115	COG2340	Cysteine-rich secretory protein family
CG475_015125	COG3336	cytochrome c oxidase
CG475_015150	COG0109	protoheme IX farnesyltransferase activity
CG475_015155	COG1612	heme a metabolic process
CG475_015160	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CG475_015170	COG0772	Belongs to the SEDS family
CG475_015175	COG4838	Belongs to the UPF0358 family
CG475_015180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CG475_015185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CG475_015195	COG4896	Protein conserved in bacteria
CG475_015220	COG0483	inositol monophosphate 1-phosphatase activity
CG475_015230	COG4493	Belongs to the UPF0637 family
CG475_015235	COG4476	Belongs to the UPF0223 family
CG475_015240	COG1982	Orn Lys Arg decarboxylase major
CG475_015280	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG475_015290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG475_015305	COG0561	phosphatase activity
CG475_015320	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG475_015325	COG0569	domain protein
CG475_015335	COG1473	amidohydrolase
CG475_015340	COG2171	N-acyltransferase activity
CG475_015345	COG0583	DNA-binding transcription factor activity
CG475_015350	COG0517	IMP dehydrogenase activity
CG475_015360	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CG475_015380	COG4703	Protein of unknown function (DUF1797)
CG475_015395	COG2200	EAL domain
CG475_015400	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_015405	COG1408	metallophosphoesterase
CG475_015415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CG475_015455	COG2814	Major facilitator Superfamily
CG475_015460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CG475_015470	COG3209	COG3209 Rhs family protein
CG475_015480	COG2205	protein histidine kinase activity
CG475_015490	COG0436	Aminotransferase
CG475_015495	COG1609	Transcriptional regulator
CG475_015500	COG3833	ABC-type maltose transport systems, permease component
CG475_015505	COG1175	transmembrane transport
CG475_015510	COG2182	Extracellular solute-binding protein
CG475_015525	COG0366	Alpha amylase catalytic
CG475_015530	COG3842	ATPase activity
CG475_015560	COG0183	Belongs to the thiolase family
CG475_015590	COG1695	Transcriptional regulator
CG475_015595	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_015605	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CG475_015610	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CG475_015615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CG475_015620	COG0436	Aminotransferase
CG475_015625	COG1850	ribulose-bisphosphate carboxylase activity
CG475_015630	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CG475_015635	COG0235	Class ii aldolase
CG475_015640	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CG475_015655	COG2084	Dehydrogenase
CG475_015670	COG0778	Nitroreductase
CG475_015695	COG2190	(PTS) system
CG475_015695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG475_015695	COG1263	PTS System
CG475_015700	COG3711	transcriptional antiterminator
CG475_015715	COG0363	glucosamine-6-phosphate deaminase activity
CG475_015730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CG475_015735	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CG475_015745	COG1547	Domain of unknown function (DUF309)
CG475_015755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CG475_015760	COG4086	secreted protein
CG475_015765	COG0561	phosphatase activity
CG475_015770	COG0697	spore germination
CG475_015785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG475_015810	COG0733	neurotransmitter:sodium symporter activity
CG475_015820	COG2172	sigma factor antagonist activity
CG475_015830	COG1686	Belongs to the peptidase S11 family
CG475_015840	COG1725	Transcriptional regulator
CG475_015845	COG1131	(ABC) transporter
CG475_015870	COG1846	Transcriptional regulator
CG475_015885	COG0598	Magnesium transport protein CorA
CG475_015915	COG4974	Belongs to the 'phage' integrase family
CG475_015925	COG0735	belongs to the Fur family
CG475_015930	COG1300	Membrane
CG475_015950	COG0667	Aldo Keto reductase
CG475_015955	COG0656	L-ascorbic acid biosynthetic process
CG475_015960	COG0456	acetyltransferase
CG475_015960	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CG475_015970	COG0737	Belongs to the 5'-nucleotidase family
CG475_015970	COG1525	nuclease
CG475_015970	COG4085	toxin activity
CG475_015980	COG0596	Alpha beta hydrolase
CG475_015985	COG2056	Na+-H+ antiporter family
CG475_015990	COG1609	Transcriptional regulator
CG475_015995	COG0456	acetyltransferase
CG475_016000	COG1073	alpha beta
CG475_016015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG475_016015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG475_016020	COG0307	riboflavin synthase, alpha
CG475_016025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG475_016025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG475_016040	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CG475_016045	COG4106	trans-aconitate 2-methyltransferase activity
CG475_016050	COG0596	Alpha beta hydrolase
CG475_016055	COG0156	8-amino-7-oxononanoate synthase activity
CG475_016065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG475_016080	COG0737	Belongs to the 5'-nucleotidase family
CG475_016105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CG475_016115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CG475_016125	COG0300	oxidoreductase activity
CG475_016130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG475_016135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG475_016140	COG1760	l-serine dehydratase
CG475_016145	COG1760	l-serine dehydratase
CG475_016155	COG1234	tRNA 3'-trailer cleavage
CG475_016175	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG475_016180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG475_016195	COG1376	ErfK ybiS ycfS ynhG family protein
CG475_016200	COG4129	membrane
CG475_016205	COG1126	abc transporter atp-binding protein
CG475_016210	COG0765	amino acid transport
CG475_016215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG475_016230	COG2816	NAD+ diphosphatase activity
CG475_016235	COG0772	Belongs to the SEDS family
CG475_016245	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG475_016250	COG0022	dehydrogenase e1 component
CG475_016255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG475_016260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG475_016265	COG3426	butyrate kinase activity
CG475_016270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG475_016275	COG0280	phosphate acetyltransferase
CG475_016285	COG3829	transcription factor binding
CG475_016285	COG3290	protein histidine kinase activity
CG475_016295	COG0584	glycerophosphoryl diester phosphodiesterase
CG475_016300	COG3093	addiction module antidote protein HigA
CG475_016305	COG0745	RESPONSE REGULATOR receiver
CG475_016310	COG0750	zinc metalloprotease
CG475_016315	COG0497	DNA recombination
CG475_016325	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CG475_016330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CG475_016340	COG1722	exodeoxyribonuclease VII activity
CG475_016345	COG1570	exodeoxyribonuclease VII activity
CG475_016350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CG475_016355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG475_016360	COG1302	Protein conserved in bacteria
CG475_016365	COG0439	Biotin carboxylase
CG475_016370	COG0511	ligase activity, forming carbon-carbon bonds
CG475_016415	COG3854	ATPases associated with a variety of cellular activities
CG475_016435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CG475_016440	COG0006	proline dipeptidase activity
CG475_016445	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CG475_016455	COG3872	metal-dependent enzyme
CG475_016465	COG1321	iron dependent repressor
CG475_016480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG475_016490	COG1609	Transcriptional regulator
CG475_016500	COG2076	Multidrug Resistance protein
CG475_016505	COG2076	Multidrug Resistance protein
CG475_016530	COG1131	(ABC) transporter
CG475_016535	COG1725	Transcriptional regulator
CG475_016550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG475_016555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG475_016560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CG475_016565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG475_016595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CG475_016620	COG1459	type II secretion system
CG475_016645	COG4824	toxin secretion phage lysis holin
CG475_016730	COG3728	DNA packaging
CG475_016740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG475_016805	COG1484	DNA-dependent DNA replication
CG475_016820	COG3723	Recombinational DNA repair protein, rece pathway
CG475_016825	COG5377	YqaJ viral recombinase family
CG475_016850	COG1396	sequence-specific DNA binding
CG475_016865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CG475_016900	COG1078	dGTPase activity
CG475_016915	COG0646	methionine synthase
CG475_016915	COG1410	methionine synthase
CG475_016920	COG0646	methionine synthase
CG475_016920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CG475_016925	COG0626	cystathionine gamma-synthase activity
CG475_016930	COG0626	cystathionine gamma-synthase activity
CG475_016950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG475_016960	COG1940	carbohydrate kinase activity
CG475_016965	COG4483	Protein conserved in bacteria
CG475_016970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CG475_016975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG475_016980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CG475_016985	COG0704	Plays a role in the regulation of phosphate uptake
CG475_016990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CG475_016995	COG0581	inorganic phosphate transmembrane transporter activity
CG475_017000	COG0573	inorganic phosphate transmembrane transporter activity
CG475_017005	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG475_017015	COG0477	Major facilitator Superfamily
CG475_017020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG475_017040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CG475_017045	COG0735	belongs to the Fur family
CG475_017050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG475_017055	COG1121	(ABC) transporter
CG475_017060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG475_017070	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CG475_017085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CG475_017090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CG475_017095	COG2384	SAM-dependent methyltransferase
CG475_017105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CG475_017110	COG0358	DNA primase activity
CG475_017115	COG1671	Belongs to the UPF0178 family
CG475_017120	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CG475_017125	COG0517	IMP dehydrogenase activity
CG475_017130	COG1381	Involved in DNA repair and RecF pathway recombination
CG475_017140	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CG475_017150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CG475_017155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CG475_017160	COG1480	7TM receptor with intracellular HD hydrolase
CG475_017165	COG1702	phosphate starvation-inducible protein PhoH
CG475_017180	COG1610	YqeY-like protein
CG475_017185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CG475_017190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG475_017195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CG475_017200	COG2264	protein methyltransferase activity
CG475_017205	COG0484	heat shock protein binding
CG475_017210	COG0443	Heat shock 70 kDa protein
CG475_017215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CG475_017220	COG1420	regulation of RNA biosynthetic process
CG475_017225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG475_017230	COG1733	regulation of RNA biosynthetic process
CG475_017235	COG0693	protein deglycase activity
CG475_017240	COG0481	GTPase activity
CG475_017255	COG0268	Binds directly to 16S ribosomal RNA
CG475_017260	COG1466	dna polymerase III delta subunit
CG475_017270	COG2333	competence protein COMEC
CG475_017270	COG0658	competence protein
CG475_017275	COG2131	deaminase
CG475_017280	COG1555	photosystem II stabilization
CG475_017280	COG1596	polysaccharide export
CG475_017285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG475_017290	COG2226	methyltransferase
CG475_017295	COG0799	negative regulation of ribosome biogenesis
CG475_017300	COG1713	HD superfamily hydrolase involved in NAD metabolism
CG475_017305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CG475_017310	COG1534	Rna-binding protein
CG475_017315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CG475_017320	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CG475_017325	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CG475_017335	COG0688	phosphatidylethanolamine metabolic process
CG475_017340	COG1191	sigma factor activity
CG475_017355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG475_017360	COG2357	RelA SpoT domain protein
CG475_017365	COG1785	Belongs to the alkaline phosphatase family
CG475_017370	COG0456	acetyltransferase
CG475_017375	COG2267	carboxylic ester hydrolase activity
CG475_017400	COG3186	Phenylalanine-4-hydroxylase
CG475_017405	COG2154	pterin-4-alpha-carbinolamine dehydratase
CG475_017410	COG2514	catechol 2,3-dioxygenase activity
CG475_017415	COG2259	Doxx family
CG475_017430	COG1609	Transcriptional regulator
CG475_017440	COG0626	cystathionine gamma-synthase activity
CG475_017445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG475_017450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CG475_017455	COG2226	methyltransferase
CG475_017470	COG0768	penicillin binding
CG475_017480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CG475_017485	COG0572	uridine kinase
CG475_017505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CG475_017515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CG475_017520	COG4472	Bacterial protein of unknown function (DUF965)
CG475_017525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG475_017530	COG0628	permease
CG475_017550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CG475_017560	COG0482	sulfurtransferase activity
CG475_017565	COG1104	cysteine desulfurase activity
CG475_017570	COG1959	2 iron, 2 sulfur cluster binding
CG475_017575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CG475_017595	COG2207	Transcriptional regulator
CG475_017605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CG475_017610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CG475_017615	COG0124	histidyl-tRNA synthetase
CG475_017635	COG1490	D-aminoacyl-tRNA deacylase activity
CG475_017640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG475_017645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG475_017650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CG475_017650	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CG475_017655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG475_017660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG475_017660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG475_017670	COG2244	polysaccharide biosynthetic process
CG475_017695	COG1862	Preprotein translocase
CG475_017700	COG0343	queuine tRNA-ribosyltransferase activity
CG475_017705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CG475_017715	COG2255	four-way junction helicase activity
CG475_017720	COG0632	four-way junction helicase activity
CG475_017725	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CG475_017745	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CG475_017750	COG0157	Belongs to the NadC ModD family
CG475_017755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CG475_017760	COG1104	cysteine desulfurase activity
CG475_017765	COG1827	regulation of RNA biosynthetic process
CG475_017770	COG2258	MOSC domain
CG475_017780	COG0577	efflux transmembrane transporter activity
CG475_017785	COG0577	efflux transmembrane transporter activity
CG475_017790	COG1136	(ABC) transporter
CG475_017795	COG5002	protein histidine kinase activity
CG475_017800	COG0745	RESPONSE REGULATOR receiver
CG475_017810	COG3290	protein histidine kinase activity
CG475_017815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CG475_017820	COG2868	ribosomal protein
CG475_017830	COG1530	ribonuclease E activity
CG475_017835	COG1994	Peptidase M50
CG475_017840	COG0739	heme binding
CG475_017845	COG2894	cell division
CG475_017850	COG0850	regulation of cytokinetic process
CG475_017860	COG1792	Involved in formation and maintenance of cell shape
CG475_017865	COG1077	Cell shape determining protein MreB Mrl
CG475_017885	COG0424	maF-like protein
CG475_017895	COG0285	dihydrofolate synthase activity
CG475_017920	COG1388	LysM domain
CG475_017920	COG1388	LysM domain
CG475_017925	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG475_017930	COG0113	porphobilinogen synthase activity
CG475_017935	COG1587	Uroporphyrinogen-III synthase
CG475_017940	COG0181	hydroxymethylbilane synthase activity
CG475_017945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG475_017950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CG475_017955	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CG475_017965	COG0470	DNA polymerase III
CG475_017965	COG1067	ATP-dependent peptidase activity
CG475_017970	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CG475_017975	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG475_018000	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_018000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG475_018000	COG4221	oxidoreductase activity
CG475_018000	COG3321	synthase
CG475_018015	COG1033	growth of symbiont in host cell
CG475_018015	COG2409	Drug exporters of the RND superfamily
CG475_018025	COG1309	transcriptional regulator
CG475_018085	COG0622	Phosphoesterase
CG475_018095	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CG475_018100	COG5401	PFAM Sporulation and spore germination
CG475_018110	COG2197	response regulator
CG475_018120	COG1959	2 iron, 2 sulfur cluster binding
CG475_018125	COG1668	transmembrane transport
CG475_018130	COG4152	abc transporter atp-binding protein
CG475_018135	COG1360	Flagellar Motor Protein
CG475_018140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG475_018150	COG1876	peptidase activity
CG475_018160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CG475_018165	COG1053	succinate dehydrogenase
CG475_018170	COG2009	succinate dehydrogenase
CG475_018175	COG1719	4-vinyl reductase, 4VR
CG475_018190	COG3118	belongs to the thioredoxin family
CG475_018195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CG475_018200	COG2086	electron transfer activity
CG475_018205	COG1024	Enoyl-CoA hydratase
CG475_018210	COG1309	transcriptional regulator
CG475_018215	COG0318	PFAM AMP-dependent synthetase and ligase
CG475_018225	COG2318	DinB family
CG475_018245	COG1131	(ABC) transporter
CG475_018250	COG2205	protein histidine kinase activity
CG475_018255	COG0745	RESPONSE REGULATOR receiver
CG475_018265	COG4895	conserved protein (DUF2196)
CG475_018270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CG475_018275	COG1114	Component of the transport system for branched-chain amino acids
CG475_018280	COG1187	pseudouridine synthase activity
CG475_018290	COG1193	negative regulation of DNA recombination
CG475_018295	COG1796	DNA polymerase
CG475_018295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CG475_018300	COG1286	toxin biosynthetic process
CG475_018305	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CG475_018330	COG0017	Asparaginyl-tRNA synthetase
CG475_018335	COG0072	phenylalanine-tRNA ligase activity
CG475_018335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG475_018340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CG475_018345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG475_018355	COG1418	mRNA catabolic process
CG475_018370	COG2814	Major facilitator Superfamily
CG475_018375	COG1566	PFAM secretion protein HlyD family protein
CG475_018380	COG1309	transcriptional regulator
CG475_018385	COG1363	Peptidase, m42
CG475_018395	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CG475_018400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CG475_018405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CG475_018410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG475_018420	COG1484	DNA-dependent DNA replication
CG475_018425	COG3611	Membrane attachment protein
CG475_018430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CG475_018435	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CG475_018445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG475_018455	COG1971	Probably functions as a manganese efflux pump
CG475_018465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG475_018465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG475_018470	COG5002	protein histidine kinase activity
CG475_018475	COG0745	RESPONSE REGULATOR receiver
CG475_018485	COG0039	L-malate dehydrogenase activity
CG475_018490	COG0538	isocitrate dehydrogenase activity
CG475_018495	COG0372	Belongs to the citrate synthase family
CG475_018500	COG2707	UPF0756 membrane protein
CG475_018505	COG0628	permease
CG475_018510	COG3030	protein affecting phage T7 exclusion by the F plasmid
CG475_018520	COG0205	6-phosphofructokinase activity
CG475_018525	COG0825	malonyl-CoA metabolic process
CG475_018530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CG475_018535	COG1725	Transcriptional regulator
CG475_018540	COG0281	malic enzyme
CG475_018545	COG0587	DNA-directed DNA polymerase activity
CG475_018560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CG475_018570	COG4109	DRTGG domain
CG475_018575	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CG475_018580	COG0006	proline dipeptidase activity
CG475_018605	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_018610	COG0589	response to stress
CG475_018635	COG0165	Argininosuccinate lyase
CG475_018640	COG0137	argininosuccinate synthase activity
CG475_018650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG475_018660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG475_018665	COG0827	DNA restriction-modification system
CG475_018670	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CG475_018675	COG3874	Sporulation protein YtfJ
CG475_018685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CG475_018690	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CG475_018695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG475_018705	COG0301	tRNA thio-modification
CG475_018710	COG1104	cysteine desulfurase activity
CG475_018715	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CG475_018720	COG0583	DNA-binding transcription factor activity
CG475_018725	COG0697	spore germination
CG475_018730	COG1309	transcriptional regulator
CG475_018735	COG1956	GAF domain-containing protein
CG475_018740	COG0626	cystathionine gamma-synthase activity
CG475_018750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CG475_018775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CG475_018785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG475_018790	COG0454	-acetyltransferase
CG475_018795	COG0517	IMP dehydrogenase activity
CG475_018800	COG0123	including yeast histone deacetylase and acetoin utilization protein
CG475_018805	COG1970	mechanosensitive ion channel activity
CG475_018815	COG1609	Transcriptional regulator
CG475_018825	COG1605	Chorismate mutase
CG475_018825	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG475_018830	COG3118	belongs to the thioredoxin family
CG475_018840	COG2309	aminopeptidase activity
CG475_018855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CG475_018865	COG1674	ftsk spoiiie
CG475_018875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG475_018880	COG4848	Belongs to the UPF0354 family
CG475_018885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG475_018890	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CG475_018910	COG1363	Peptidase, m42
CG475_018920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG475_018925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CG475_018935	COG0510	thiamine kinase activity
CG475_018940	COG1523	belongs to the glycosyl hydrolase 13 family
CG475_018950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG475_018955	COG1349	DNA-binding transcription factor activity
CG475_018960	COG1187	pseudouridine synthase activity
CG475_018965	COG2244	polysaccharide biosynthetic process
CG475_018970	COG2081	HI0933 family
CG475_018975	COG2814	Major facilitator Superfamily
CG475_018985	COG3832	glyoxalase III activity
CG475_019005	COG1329	Transcriptional regulator
CG475_019015	COG2223	nitrite transmembrane transporter activity
CG475_019025	COG0314	molybdopterin synthase activity
CG475_019030	COG1763	Mo-molybdopterin cofactor biosynthetic process
CG475_019035	COG0303	'Molybdopterin
CG475_019040	COG0315	cyclic pyranopterin monophosphate synthase activity
CG475_019045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG475_019050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CG475_019055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG475_019060	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CG475_019065	COG1140	nitrate reductase beta subunit
CG475_019070	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CG475_019075	COG2181	nitrate reductase activity
CG475_019090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG475_019100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CG475_019135	COG0495	leucyl-tRNA aminoacylation
CG475_019140	COG2814	Major facilitator Superfamily
CG475_019150	COG1136	(ABC) transporter
CG475_019155	COG0346	lactoylglutathione lyase activity
CG475_019170	COG1242	4 iron, 4 sulfur cluster binding
CG475_019175	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CG475_019180	COG1121	(ABC) transporter
CG475_019190	COG1794	racemase activity, acting on amino acids and derivatives
CG475_019200	COG2378	regulation of single-species biofilm formation
CG475_019210	COG2267	carboxylic ester hydrolase activity
CG475_019215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CG475_019225	COG0746	molybdenum cofactor guanylyltransferase activity
CG475_019250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CG475_019260	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CG475_019310	COG0800	Aldolase
CG475_019315	COG2610	gluconate transmembrane transporter activity
CG475_019320	COG1312	Catalyzes the dehydration of D-mannonate
CG475_019330	COG1414	Transcriptional regulator
CG475_019335	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG475_019335	COG3409	Peptidoglycan-binding domain 1 protein
CG475_019345	COG1368	sulfuric ester hydrolase activity
CG475_019360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG475_019365	COG1116	anion transmembrane transporter activity
CG475_019370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG475_019385	COG0494	nUDIX hydrolase
CG475_019395	COG1854	S-ribosylhomocysteine lyase activity
CG475_019400	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CG475_019405	COG0288	reversible hydration of carbon dioxide
CG475_019410	COG1271	oxidase subunit
CG475_019415	COG1294	oxidase, subunit
CG475_019445	COG1842	Phage shock protein A
CG475_019490	COG1597	lipid kinase activity
CG475_019495	COG1136	(ABC) transporter
CG475_019505	COG0745	RESPONSE REGULATOR receiver
CG475_019510	COG2205	protein histidine kinase activity
CG475_019515	COG0577	efflux transmembrane transporter activity
CG475_019520	COG1136	(ABC) transporter
CG475_019540	COG4948	Mandelate Racemase Muconate Lactonizing
CG475_019545	COG0318	PFAM AMP-dependent synthetase and ligase
CG475_019550	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CG475_019555	COG0596	Alpha beta hydrolase
CG475_019560	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CG475_019565	COG1169	isochorismate synthase
CG475_019570	COG1575	Belongs to the MenA family. Type 1 subfamily
CG475_019575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CG475_019580	COG1278	Cold shock
CG475_019600	COG0058	SHG alpha-glucan phosphorylase activity
CG475_019605	COG0297	glycogen (starch) synthase activity
CG475_019610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG475_019615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG475_019620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CG475_019625	COG0039	L-malate dehydrogenase activity
CG475_019720	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG475_019755	COG1285	pathogenesis
CG475_019760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG475_019770	COG0166	Belongs to the GPI family
CG475_019780	COG2155	Conserved Protein
CG475_019785	COG1098	S1 RNA binding domain
CG475_019790	COG0436	Aminotransferase
CG475_019795	COG1522	sequence-specific DNA binding
CG475_019800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG475_019805	COG2267	carboxylic ester hydrolase activity
CG475_019815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CG475_019820	COG2032	superoxide dismutase activity
CG475_019830	COG5018	Exonuclease
CG475_019835	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG475_019840	COG0423	glycine-tRNA ligase activity
CG475_019860	COG2050	protein possibly involved in aromatic compounds catabolism
CG475_019870	COG1268	BioY protein
CG475_019875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG475_019880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG475_019890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CG475_019900	COG3584	3D domain protein
CG475_019920	COG1252	NADH dehydrogenase
CG475_019925	COG0492	ferredoxin-NADP+ reductase activity
CG475_019940	COG1683	Conserved Protein
CG475_019975	COG1131	(ABC) transporter
CG475_020000	COG0316	Belongs to the HesB IscA family
CG475_020005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CG475_020010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG475_020020	COG1252	NADH dehydrogenase
CG475_020025	COG2824	Alkylphosphonate utilization operon protein PhnA
CG475_020035	COG3655	Transcriptional regulator
CG475_020050	COG4837	Protein of unknown function (DUF1462)
CG475_020055	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CG475_020060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG475_020065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CG475_020070	COG0647	UMP catabolic process
CG475_020080	COG2445	Protein of unknown function DUF86
CG475_020085	COG1494	fructose-1,6-bisphosphatase
CG475_020095	COG4470	Protein conserved in bacteria
CG475_020105	COG0789	Transcriptional regulator
CG475_020110	COG4377	Putative membrane peptidase family (DUF2324)
CG475_020125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CG475_020130	COG0739	heme binding
CG475_020140	COG3377	Domain of unknown function (DUF1805)
CG475_020145	COG0737	Belongs to the 5'-nucleotidase family
CG475_020165	COG0719	Fe-S assembly protein
CG475_020170	COG0822	iron-sulfur transferase activity
CG475_020175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CG475_020180	COG0719	Fe-S assembly protein
CG475_020185	COG0396	ATPase activity
CG475_020190	COG1464	Belongs to the NlpA lipoprotein family
CG475_020195	COG2011	ABC-type metal ion transport system permease component
CG475_020210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG475_020215	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CG475_020225	COG0509	glycine decarboxylation via glycine cleavage system
CG475_020230	COG1393	Belongs to the ArsC family
CG475_020270	COG1960	acyl-CoA dehydrogenase activity
CG475_020275	COG0183	Belongs to the thiolase family
CG475_020280	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG475_020280	COG1024	Enoyl-CoA hydratase
CG475_020290	COG1686	Belongs to the peptidase S11 family
CG475_020315	COG0011	TIGRFAM Protein of
CG475_020320	COG0840	transmembrane signaling receptor activity
CG475_020340	COG0531	amino acid
CG475_020345	COG0706	membrane insertase activity
CG475_020355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG475_020365	COG0586	Pfam SNARE associated Golgi protein
CG475_020375	COG1376	ErfK ybiS ycfS ynhG family protein
CG475_020380	COG0745	RESPONSE REGULATOR receiver
CG475_020385	COG5002	protein histidine kinase activity
CG475_020390	COG0840	transmembrane signaling receptor activity
CG475_020395	COG0840	transmembrane signaling receptor activity
CG475_020400	COG2151	metal-sulfur cluster biosynthetic enzyme
CG475_020405	COG3227	Zinc metalloprotease (Elastase)
CG475_020410	COG1741	Belongs to the pirin family
CG475_020425	COG0783	Belongs to the Dps family
CG475_020430	COG1611	Belongs to the LOG family
CG475_020455	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG475_020460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG475_020465	COG1121	(ABC) transporter
CG475_020485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG475_020490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG475_020495	COG1115	amino acid carrier protein
CG475_020500	COG2910	NAD(P)H-binding
CG475_020515	COG1252	NADH dehydrogenase
CG475_020530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG475_020545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG475_020550	COG1917	Cupin 2, conserved barrel domain protein
CG475_020550	COG4977	sequence-specific DNA binding
CG475_020555	COG3223	Belongs to the PsiE family
CG475_020560	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CG475_020580	COG0697	spore germination
CG475_020595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CG475_020600	COG0557	exoribonuclease II activity
CG475_020605	COG1647	Serine aminopeptidase, S33
CG475_020610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CG475_020615	COG1346	cytolysis
CG475_020625	COG0148	phosphopyruvate hydratase activity
CG475_020630	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CG475_020635	COG0149	triose-phosphate isomerase activity
CG475_020640	COG0126	phosphoglycerate kinase activity
CG475_020645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG475_020660	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CG475_020710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG475_020725	COG2323	membrane
CG475_020735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG475_020740	COG1481	regulation of sporulation
CG475_020745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CG475_020750	COG1660	Displays ATPase and GTPase activities
CG475_020755	COG1051	belongs to the nudix hydrolase family
CG475_020765	COG0492	ferredoxin-NADP+ reductase activity
CG475_020770	COG0457	Tetratricopeptide repeat
CG475_020775	COG0110	maltose O-acetyltransferase activity
CG475_020785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CG475_020790	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CG475_020795	COG1950	PFAM Membrane protein of
CG475_020805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CG475_020820	COG0789	Transcriptional regulator
CG475_020840	COG0583	DNA-binding transcription factor activity
CG475_020855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG475_020860	COG3409	Peptidoglycan-binding domain 1 protein
CG475_020860	COG0793	Belongs to the peptidase S41A family
CG475_020865	COG2177	Part of the ABC transporter FtsEX involved in
CG475_020870	COG2884	Cell division ATP-binding protein ftsE
CG475_020905	COG1278	Cold shock
CG475_020910	COG1040	competence protein
CG475_020915	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CG475_020920	COG1388	LysM domain
CG475_020920	COG0791	NLP P60 protein
CG475_020925	COG1733	regulation of RNA biosynthetic process
CG475_020930	COG1307	EDD domain protein, DegV family
CG475_020935	COG1739	Uncharacterized protein family UPF0029
CG475_020940	COG1316	TRANSCRIPTIONal
CG475_020950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CG475_020960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG475_020970	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CG475_020970	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CG475_020985	COG1486	melibiose metabolic process
CG475_020990	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG475_021005	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG475_021010	COG1301	dicarboxylic acid transport
CG475_021015	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CG475_021025	COG1271	oxidase subunit
CG475_021030	COG1294	oxidase, subunit
CG475_021035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CG475_021040	COG1620	l-lactate permease
CG475_021045	COG2389	metal-binding protein
CG475_021055	COG1368	sulfuric ester hydrolase activity
CG475_021065	COG0791	NLP P60 protein
CG475_021065	COG1388	LysM domain
CG475_021070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG475_021080	COG1215	transferase activity, transferring glycosyl groups
CG475_021090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG475_021095	COG3584	3D domain protein
CG475_021095	COG1388	LysM domain
CG475_021115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG475_021155	COG0577	efflux transmembrane transporter activity
CG475_021160	COG1136	(ABC) transporter
CG475_021195	COG3850	Histidine kinase
CG475_021195	COG5002	protein histidine kinase activity
CG475_021200	COG0745	RESPONSE REGULATOR receiver
CG475_021210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG475_021220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG475_021220	COG1215	transferase activity, transferring glycosyl groups
CG475_021225	COG1134	teichoic acid transport
CG475_021230	COG1682	transport, permease protein
CG475_021235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG475_021240	COG0463	Glycosyl transferase, family 2
CG475_021240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG475_021245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG475_021250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CG475_021265	COG1609	Transcriptional regulator
CG475_021275	COG0739	heme binding
CG475_021290	COG3279	Response regulator of the LytR AlgR family
CG475_021295	COG2385	sporulation resulting in formation of a cellular spore
CG475_021310	COG4836	Membrane
CG475_021315	COG1007	ATP synthesis coupled electron transport
CG475_021320	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG475_021325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG475_021330	COG0713	ATP synthesis coupled electron transport
CG475_021335	COG0839	Belongs to the complex I subunit 6 family
CG475_021345	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CG475_021350	COG0649	NAD binding
CG475_021355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG475_021360	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG475_021365	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG475_021370	COG3300	MHYT domain
CG475_021370	COG5001	Diguanylate cyclase
CG475_021375	COG5001	Diguanylate cyclase
CG475_021375	COG3300	MHYT domain
CG475_021390	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CG475_021395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CG475_021405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CG475_021410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CG475_021415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG475_021420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CG475_021425	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG475_021450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CG475_021455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CG475_021465	COG0698	ribose 5-phosphate isomerase
CG475_021485	COG2190	(PTS) system
CG475_021490	COG2259	Doxx family
CG475_021495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CG475_021510	COG0009	L-threonylcarbamoyladenylate synthase
CG475_021525	COG2890	protein-(glutamine-N5) methyltransferase activity
CG475_021530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CG475_021535	COG1435	thymidine kinase activity
CG475_021545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CG475_021550	COG1494	fructose-1,6-bisphosphatase
CG475_021570	COG4821	SIS domain
CG475_021575	COG0504	CTP synthase activity
CG475_021590	COG1960	acyl-CoA dehydrogenase activity
CG475_021595	COG1960	acyl-CoA dehydrogenase activity
CG475_021600	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG475_021605	COG0183	Belongs to the thiolase family
CG475_021610	COG0247	lactate metabolic process
CG475_021610	COG2181	nitrate reductase activity
CG475_021615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG475_021630	COG2197	response regulator
CG475_021635	COG4585	Histidine kinase
CG475_021640	COG0842	Transport permease protein
CG475_021645	COG1131	(ABC) transporter
CG475_021650	COG0024	Methionine aminopeptidase
CG475_021655	COG2234	aminopeptidase activity
CG475_021670	COG4506	Protein conserved in bacteria
CG475_021675	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG475_021690	COG0010	Belongs to the arginase family
CG475_021695	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CG475_021700	COG2814	Major facilitator Superfamily
CG475_021705	COG0789	Transcriptional regulator
CG475_021710	COG0584	glycerophosphoryl diester phosphodiesterase
CG475_021715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG475_021725	COG1994	Peptidase M50
CG475_021735	COG1078	dGTPase activity
CG475_021740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG475_021745	COG1120	ATPase activity
CG475_021750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG475_021755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG475_021760	COG4844	belongs to the
CG475_021775	COG0280	phosphate acetyltransferase
CG475_021790	COG3773	Cell wall hydrolase
CG475_021800	COG2363	Small membrane protein
CG475_021810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG475_021815	COG2233	PERMEase
CG475_021820	COG0561	phosphatase activity
CG475_021825	COG2814	Major facilitator Superfamily
CG475_021830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CG475_021835	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG475_021840	COG1131	(ABC) transporter
CG475_021845	COG2755	lipolytic protein G-D-S-L family
CG475_021850	COG0460	homoserine dehydrogenase
CG475_021855	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CG475_021870	COG0351	phosphomethylpyrimidine kinase
CG475_021880	COG1966	Carbon starvation protein
CG475_021885	COG3279	Response regulator of the LytR AlgR family
CG475_021890	COG0477	Major facilitator Superfamily
CG475_021900	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CG475_021905	COG0438	transferase activity, transferring glycosyl groups
CG475_021920	COG0840	transmembrane signaling receptor activity
CG475_021935	COG1607	acyl-coa hydrolase
CG475_021940	COG1216	Glycosyl transferase, family 2
CG475_021955	COG0463	Glycosyl transferase, family 2
CG475_021970	COG0463	Glycosyl transferase, family 2
CG475_021975	COG0488	(ABC) transporter
CG475_021980	COG1309	transcriptional regulator
CG475_021985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG475_021990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG475_021990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG475_021995	COG0628	permease
CG475_022000	COG1346	cytolysis
CG475_022010	COG3279	Response regulator of the LytR AlgR family
CG475_022015	COG3275	phosphorelay sensor kinase activity
CG475_022020	COG2814	Major facilitator Superfamily
CG475_022025	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CG475_022030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG475_022040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG475_022045	COG3711	transcriptional antiterminator
CG475_022045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG475_022100	COG0582	viral genome integration into host DNA
CG475_022115	COG1132	(ABC) transporter
CG475_022125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CG475_022135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG475_022140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CG475_022145	COG4853	Protein conserved in bacteria
CG475_022155	COG5002	protein histidine kinase activity
CG475_022160	COG0745	RESPONSE REGULATOR receiver
CG475_022185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CG475_022190	COG0305	Participates in initiation and elongation during chromosome replication
CG475_022195	COG0359	binds to the 23S rRNA
CG475_022200	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CG475_022205	COG4241	membrane
CG475_022210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CG475_022215	COG0629	single-stranded DNA binding
CG475_022220	COG0360	Binds together with S18 to 16S ribosomal RNA
CG475_022225	COG0012	GTP binding
CG475_022230	COG4481	Protein conserved in bacteria
CG475_022235	COG0668	transmembrane transport
CG475_022245	COG1475	DNA binding
CG475_022250	COG1192	Involved in chromosome partitioning
CG475_022255	COG1475	DNA binding
CG475_022260	COG0357	Ribosomal RNA small subunit methyltransferase G
CG475_022265	COG0445	tRNA wobble uridine modification
CG475_022270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CG475_022275	COG1847	R3H domain protein
CG475_022280	COG0706	membrane insertase activity
CG475_022285	COG0594	ribonuclease P activity
CG475_022365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG475_022380	COG0583	DNA-binding transcription factor activity
CG475_022400	COG1028	Short-chain dehydrogenase reductase Sdr
CG475_022510	COG0791	NLP P60 protein
CG475_022510	COG0741	lytic transglycosylase activity
CG475_022660	COG1192	Involved in chromosome partitioning
CG475_022700	COG0457	Tetratricopeptide repeat
CG475_022710	COG4166	transmembrane transport
CG475_022745	COG4974	Belongs to the 'phage' integrase family