locus-tag	class	description
CG478_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CG478_000010	COG0592	DNA-directed DNA polymerase activity
CG478_000015	COG2501	S4 domain
CG478_000020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CG478_000025	COG0187	DNA topoisomerase II activity
CG478_000030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG478_000065	COG0517	IMP dehydrogenase activity
CG478_000065	COG0516	GMP reductase activity
CG478_000070	COG1686	Belongs to the peptidase S11 family
CG478_000075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CG478_000080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CG478_000085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CG478_000100	COG1428	Deoxynucleoside kinase
CG478_000105	COG1428	Deoxynucleoside kinase
CG478_000110	COG1335	isochorismatase
CG478_000115	COG0590	tRNA wobble adenosine to inosine editing
CG478_000125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CG478_000130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CG478_000135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CG478_000180	COG1982	Orn Lys Arg decarboxylase major
CG478_000185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CG478_000190	COG0470	DNA polymerase III
CG478_000195	COG1774	PSP1 C-terminal conserved region
CG478_000200	COG4467	Involved in initiation control of chromosome replication
CG478_000205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CG478_000215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CG478_000220	COG2002	toxin-antitoxin pair type II binding
CG478_000230	COG0084	hydrolase, TatD family'
CG478_000240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CG478_000250	COG4466	Protein conserved in bacteria
CG478_000260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CG478_000265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG478_000270	COG0251	oxidation-reduction process
CG478_000275	COG2088	sporulation resulting in formation of a cellular spore
CG478_000280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CG478_000285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CG478_000290	COG0193	aminoacyl-tRNA hydrolase activity
CG478_000300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CG478_000305	COG2002	toxin-antitoxin pair type II binding
CG478_000310	COG2244	polysaccharide biosynthetic process
CG478_000315	COG3956	TIGRFAM MazG family protein
CG478_000320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CG478_000340	COG1098	S1 RNA binding domain
CG478_000355	COG2208	phosphoserine phosphatase activity
CG478_000370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CG478_000375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CG478_000380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CG478_000385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG478_000390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CG478_000395	COG0512	Glutamine amidotransferase of anthranilate synthase
CG478_000400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG478_000405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CG478_000410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CG478_000415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CG478_000420	COG1396	sequence-specific DNA binding
CG478_000425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG478_000430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CG478_000465	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG478_000515	COG3880	PFAM UvrB UvrC protein
CG478_000520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CG478_000525	COG0542	response to heat
CG478_000530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CG478_000540	COG4956	integral membrane protein (PIN domain superfamily)
CG478_000545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CG478_000550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CG478_000555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CG478_000560	COG1045	serine acetyltransferase
CG478_000565	COG0215	cysteine-tRNA ligase activity
CG478_000575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG478_000580	COG3688	RNA-binding protein containing a PIN domain
CG478_000600	COG0250	Participates in transcription elongation, termination and antitermination
CG478_000610	COG0081	regulation of translation
CG478_000615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CG478_000620	COG0222	ribosome binding
CG478_000625	COG2813	Specifically methylates the guanine in position
CG478_000635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CG478_000640	COG1358	cellular component organization or biogenesis
CG478_000645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CG478_000650	COG0049	tRNA binding
CG478_000655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CG478_000660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CG478_000670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CG478_000675	COG0088	Forms part of the polypeptide exit tunnel
CG478_000680	COG0089	rRNA binding
CG478_000685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CG478_000690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CG478_000695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CG478_000700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CG478_000705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CG478_000715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CG478_000720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CG478_000725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CG478_000730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CG478_000740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CG478_000745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CG478_000750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CG478_000755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CG478_000760	COG1841	ribosomal large subunit assembly
CG478_000765	COG0200	Binds to the 23S rRNA
CG478_000770	COG0201	protein transport
CG478_000775	COG0563	adenylate kinase activity
CG478_000780	COG0024	Methionine aminopeptidase
CG478_000790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CG478_000800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CG478_000805	COG0202	RNA polymerase activity
CG478_000820	COG1122	ATPase activity
CG478_000825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG478_000835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CG478_000840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CG478_000850	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG478_000855	COG0489	protein tyrosine kinase activity
CG478_000865	COG2194	sulfuric ester hydrolase activity
CG478_000870	COG0726	polysaccharide deacetylase
CG478_000900	COG4974	Belongs to the 'phage' integrase family
CG478_001055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CG478_001065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG478_001105	COG1396	sequence-specific DNA binding
CG478_001110	COG0602	queuosine metabolic process
CG478_001220	COG3681	Belongs to the UPF0597 family
CG478_001225	COG3681	Belongs to the UPF0597 family
CG478_001250	COG2814	Major facilitator Superfamily
CG478_001260	COG0601	transmembrane transport
CG478_001265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG478_001270	COG0444	Belongs to the ABC transporter superfamily
CG478_001275	COG4608	Belongs to the ABC transporter superfamily
CG478_001280	COG4166	transmembrane transport
CG478_001290	COG2207	Transcriptional regulator
CG478_001300	COG1309	transcriptional regulator
CG478_001310	COG0656	L-ascorbic acid biosynthetic process
CG478_001315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG478_001325	COG4149	molybdate abc transporter
CG478_001330	COG0725	ABC transporter, periplasmic molybdate-binding protein
CG478_001335	COG1910	domain protein
CG478_001340	COG0204	Acyl-transferase
CG478_001345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG478_001350	COG1648	precorrin-2 dehydrogenase activity
CG478_001350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG478_001360	COG1587	Uroporphyrinogen-III synthase
CG478_001360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG478_001365	COG2146	nitrite reductase [NAD(P)H] activity
CG478_001370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG478_001400	COG4585	Histidine kinase
CG478_001405	COG2197	response regulator
CG478_001410	COG1131	(ABC) transporter
CG478_001415	COG1511	domain protein
CG478_001415	COG0842	Transport permease protein
CG478_001430	COG0747	negative chemotaxis
CG478_001435	COG0601	transmembrane transport
CG478_001440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG478_001445	COG0444	Belongs to the ABC transporter superfamily
CG478_001450	COG4608	Belongs to the ABC transporter superfamily
CG478_001455	COG0561	phosphatase activity
CG478_001475	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CG478_001480	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG478_001490	COG2814	Major facilitator Superfamily
CG478_001495	COG1181	Belongs to the D-alanine--D-alanine ligase family
CG478_001500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CG478_001510	COG0705	Rhomboid family
CG478_001510	COG0457	Tetratricopeptide repeat
CG478_001515	COG0736	holo-[acyl-carrier-protein] synthase activity
CG478_001520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CG478_001530	COG0864	Transcriptional regulator
CG478_001535	COG2337	Toxic component of a toxin-antitoxin (TA) module
CG478_001540	COG2183	response to ionizing radiation
CG478_001550	COG3091	SprT-like family
CG478_001590	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG478_001640	COG0802	atpase or kinase
CG478_001645	COG1214	PFAM Peptidase M22, glycoprotease
CG478_001650	COG0456	acetyltransferase
CG478_001660	COG0488	(ABC) transporter
CG478_001665	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CG478_001675	COG1266	CAAX protease self-immunity
CG478_001680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CG478_001685	COG0459	protein refolding
CG478_001690	COG0519	Catalyzes the synthesis of GMP from XMP
CG478_001690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CG478_001695	COG2252	PERMEase
CG478_001705	COG5002	protein histidine kinase activity
CG478_001775	COG2205	protein histidine kinase activity
CG478_001780	COG0745	RESPONSE REGULATOR receiver
CG478_001800	COG0697	spore germination
CG478_001825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CG478_001830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CG478_001835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CG478_001840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CG478_001845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG478_001850	COG0047	phosphoribosylformylglycinamidine synthase activity
CG478_001855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG478_001860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CG478_001865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CG478_001870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CG478_001875	COG0138	bifunctional purine biosynthesis protein purh
CG478_001880	COG0151	Belongs to the GarS family
CG478_001890	COG0583	DNA-binding transcription factor activity
CG478_001910	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CG478_001915	COG0210	DNA helicase
CG478_001920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CG478_001925	COG4851	CamS sex pheromone cAM373 precursor
CG478_001935	COG1012	belongs to the aldehyde dehydrogenase family
CG478_001940	COG1335	isochorismatase
CG478_001950	COG2011	ABC-type metal ion transport system permease component
CG478_001955	COG1464	Belongs to the NlpA lipoprotein family
CG478_001970	COG4682	membrane
CG478_001975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG478_001980	COG0154	amidase activity
CG478_001985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG478_001990	COG1597	lipid kinase activity
CG478_001995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CG478_002000	COG0546	phosphoglycolate phosphatase activity
CG478_002005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CG478_002015	COG0531	amino acid
CG478_002020	COG1012	belongs to the aldehyde dehydrogenase family
CG478_002025	COG2076	Multidrug Resistance protein
CG478_002030	COG2309	aminopeptidase activity
CG478_002045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG478_002050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG478_002055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG478_002070	COG0450	alkyl hydroperoxide reductase
CG478_002095	COG0714	Associated with various cellular activities
CG478_002130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG478_002135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG478_002140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG478_002145	COG0492	ferredoxin-NADP+ reductase activity
CG478_002155	COG0166	Belongs to the GPI family
CG478_002160	COG5002	protein histidine kinase activity
CG478_002185	COG3541	Predicted nucleotidyltransferase
CG478_002190	COG2814	Major facilitator Superfamily
CG478_002195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG478_002195	COG0723	plastoquinol--plastocyanin reductase activity
CG478_002205	COG0765	amino acid transport
CG478_002210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG478_002215	COG1126	abc transporter atp-binding protein
CG478_002220	COG0840	transmembrane signaling receptor activity
CG478_002230	COG4841	protein insertion into membrane
CG478_002235	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CG478_002250	COG0745	RESPONSE REGULATOR receiver
CG478_002255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG478_002260	COG1832	CoA-binding protein
CG478_002270	COG0187	DNA topoisomerase II activity
CG478_002275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG478_002280	COG0673	inositol 2-dehydrogenase activity
CG478_002285	COG1301	dicarboxylic acid transport
CG478_002290	COG4166	transmembrane transport
CG478_002295	COG4166	transmembrane transport
CG478_002300	COG2226	methyltransferase
CG478_002335	COG2962	Rard protein
CG478_002340	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CG478_002345	COG1657	PFAM Prenyltransferase squalene oxidase
CG478_002355	COG1012	belongs to the aldehyde dehydrogenase family
CG478_002365	COG4145	pantothenate transmembrane transporter activity
CG478_002380	COG3409	Peptidoglycan-binding domain 1 protein
CG478_002395	COG0165	Argininosuccinate lyase
CG478_002400	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_002410	COG1278	Cold shock
CG478_002435	COG0582	viral genome integration into host DNA
CG478_002485	COG1484	DNA-dependent DNA replication
CG478_002590	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CG478_002790	COG2720	vancomycin resistance protein
CG478_002795	COG1285	pathogenesis
CG478_002800	COG0277	FAD linked oxidase domain protein
CG478_002805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CG478_002815	COG3397	chitin binding
CG478_002845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG478_002850	COG0584	glycerophosphoryl diester phosphodiesterase
CG478_002870	COG1164	Oligoendopeptidase f
CG478_002875	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CG478_002880	COG1193	negative regulation of DNA recombination
CG478_002895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG478_002900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG478_002925	COG2072	flavoprotein involved in K transport
CG478_002990	COG1136	(ABC) transporter
CG478_002990	COG0577	efflux transmembrane transporter activity
CG478_002995	COG4591	ABC-type transport system involved in lipoprotein release permease component
CG478_003035	COG0582	viral genome integration into host DNA
CG478_003115	COG3813	Protein conserved in bacteria
CG478_003120	COG0789	Transcriptional regulator
CG478_003125	COG1253	flavin adenine dinucleotide binding
CG478_003135	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CG478_003140	COG0579	oxidoreductase
CG478_003145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG478_003150	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CG478_003210	COG1131	(ABC) transporter
CG478_003225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CG478_003250	COG1122	ATPase activity
CG478_003285	COG2031	fatty acid transporter
CG478_003295	COG2814	Major facilitator Superfamily
CG478_003300	COG1846	Transcriptional regulator
CG478_003315	COG0477	Major facilitator Superfamily
CG478_003440	COG4851	CamS sex pheromone cAM373 precursor
CG478_003460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CG478_003470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG478_003475	COG0438	transferase activity, transferring glycosyl groups
CG478_003480	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG478_003495	COG0438	transferase activity, transferring glycosyl groups
CG478_003500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG478_003505	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CG478_003510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG478_003520	COG0346	lactoylglutathione lyase activity
CG478_003550	COG1960	acyl-CoA dehydrogenase activity
CG478_003565	COG1414	Transcriptional regulator
CG478_003570	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CG478_003575	COG1984	allophanate hydrolase subunit 2
CG478_003580	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CG478_003595	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CG478_003620	COG0833	amino acid
CG478_003630	COG0730	response to heat
CG478_003645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG478_003655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG478_003660	COG0697	spore germination
CG478_003675	COG0477	Major facilitator Superfamily
CG478_003680	COG0456	acetyltransferase
CG478_003695	COG0494	nUDIX hydrolase
CG478_003720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG478_003735	COG2329	Antibiotic biosynthesis monooxygenase
CG478_003775	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG478_003780	COG3547	Transposase (IS116 IS110 IS902 family)
CG478_003790	COG0346	lactoylglutathione lyase activity
CG478_003810	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG478_003810	COG1605	Chorismate mutase
CG478_003815	COG0488	(ABC) transporter
CG478_003820	COG1368	sulfuric ester hydrolase activity
CG478_003825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG478_003835	COG3037	sugar-specific permease SgaT UlaA
CG478_003840	COG0726	polysaccharide deacetylase
CG478_003850	COG0456	acetyltransferase
CG478_003850	COG0454	-acetyltransferase
CG478_003865	COG2746	aminoglycoside 3-N-acetyltransferase activity
CG478_003880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG478_003885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG478_003890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG478_003905	COG0628	permease
CG478_003930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG478_003935	COG3973	AAA domain
CG478_003950	COG0436	Aminotransferase
CG478_003975	COG0675	Transposase, IS605 OrfB family
CG478_003980	COG2261	transglycosylase associated protein
CG478_004000	COG5444	nuclease activity
CG478_004110	COG5444	nuclease activity
CG478_004160	COG1307	EDD domain protein, DegV family
CG478_004240	COG4948	Mandelate Racemase Muconate Lactonizing
CG478_004250	COG4166	transmembrane transport
CG478_004290	COG3397	chitin binding
CG478_004300	COG1227	inorganic diphosphatase activity
CG478_004305	COG4637	Psort location Cytoplasmic, score
CG478_004325	COG0514	ATP-dependent DNA helicase (RecQ)
CG478_004355	COG2153	protein acetylation
CG478_004385	COG0517	IMP dehydrogenase activity
CG478_004385	COG4175	Glycine betaine
CG478_004390	COG4176	ABC-type proline glycine betaine transport system permease component
CG478_004400	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_004410	COG3844	kynureninase activity
CG478_004415	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CG478_004440	COG3409	Peptidoglycan-binding domain 1 protein
CG478_004440	COG3773	Cell wall hydrolase
CG478_004445	COG2959	enzyme of heme biosynthesis
CG478_004455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG478_004465	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG478_004470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG478_004500	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG478_004510	COG0457	Tetratricopeptide repeat
CG478_004545	COG2124	cytochrome p450
CG478_004565	COG0561	phosphatase activity
CG478_004570	COG5002	protein histidine kinase activity
CG478_004575	COG2828	Protein conserved in bacteria
CG478_004585	COG1794	racemase activity, acting on amino acids and derivatives
CG478_004625	COG1279	arginine transmembrane transporter activity
CG478_004630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG478_004645	COG1216	Glycosyl transferase, family 2
CG478_004695	COG2223	nitrite transmembrane transporter activity
CG478_004745	COG1051	belongs to the nudix hydrolase family
CG478_004765	COG4667	esterase of the alpha-beta hydrolase superfamily
CG478_004780	COG0322	excinuclease ABC activity
CG478_004785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG478_004805	COG0201	protein transport
CG478_004810	COG0693	protein deglycase activity
CG478_004825	COG3409	Peptidoglycan-binding domain 1 protein
CG478_004825	COG3773	Cell wall hydrolase
CG478_004830	COG2002	toxin-antitoxin pair type II binding
CG478_004835	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_004845	COG1309	transcriptional regulator
CG478_004865	COG0475	glutathione-regulated potassium exporter activity
CG478_004890	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_004900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG478_004920	COG0789	Transcriptional regulator
CG478_004950	COG5002	protein histidine kinase activity
CG478_004955	COG1686	Belongs to the peptidase S11 family
CG478_004965	COG0640	Transcriptional regulator
CG478_004970	COG1216	Glycosyl transferase, family 2
CG478_004980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG478_004985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CG478_004990	COG1024	Enoyl-CoA hydratase
CG478_004995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG478_005000	COG0511	ligase activity, forming carbon-carbon bonds
CG478_005005	COG0439	Biotin carboxylase
CG478_005010	COG1960	acyl-CoA dehydrogenase activity
CG478_005020	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG478_005050	COG0588	phosphoglycerate mutase activity
CG478_005070	COG2971	BadF BadG BcrA BcrD
CG478_005090	COG1649	PFAM Uncharacterised BCR, COG1649
CG478_005115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG478_005120	COG1132	(ABC) transporter
CG478_005125	COG1132	(ABC) transporter
CG478_005135	COG0010	Belongs to the arginase family
CG478_005155	COG0667	Aldo Keto reductase
CG478_005165	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG478_005200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG478_005205	COG2329	Antibiotic biosynthesis monooxygenase
CG478_005220	COG0776	regulation of translation
CG478_005240	COG3251	PFAM MbtH domain protein
CG478_005245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG478_005250	COG3433	isochorismatase activity
CG478_005250	COG1535	isochorismatase
CG478_005255	COG1021	2,3-dihydroxybenzoate-AMP ligase
CG478_005260	COG1169	isochorismate synthase
CG478_005265	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_005300	COG0457	Tetratricopeptide repeat
CG478_005335	COG1942	4-Oxalocrotonate Tautomerase
CG478_005355	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG478_005360	COG1131	(ABC) transporter
CG478_005380	COG1131	(ABC) transporter
CG478_005385	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG478_005415	COG3104	oligopeptide transport
CG478_005420	COG0419	ATPase involved in DNA repair
CG478_005425	COG0420	3'-5' exonuclease activity
CG478_005445	COG1280	lysine exporter protein (LysE YggA)
CG478_005455	COG1012	belongs to the aldehyde dehydrogenase family
CG478_005460	COG2084	Dehydrogenase
CG478_005465	COG1960	acyl-CoA dehydrogenase activity
CG478_005470	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CG478_005475	COG2079	MmgE PrpD family protein
CG478_005480	COG0372	Belongs to the citrate synthase family
CG478_005490	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG478_005490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG478_005520	COG3403	YqcI/YcgG family
CG478_005525	COG1280	lysine exporter protein (LysE YggA)
CG478_005535	COG0671	phosphoesterase, PA-phosphatase related
CG478_005540	COG2323	membrane
CG478_005545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG478_005550	COG1408	metallophosphoesterase
CG478_005555	COG0726	polysaccharide deacetylase
CG478_005565	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CG478_005610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG478_005615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG478_005620	COG0671	phosphoesterase, PA-phosphatase related
CG478_005625	COG1357	PFAM Pentapeptide repeats (8 copies)
CG478_005625	COG0515	serine threonine protein kinase
CG478_005650	COG4479	Belongs to the UPF0346 family
CG478_005660	COG1509	lysine 2,3-aminomutase activity
CG478_005670	COG3829	transcription factor binding
CG478_005680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG478_005685	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CG478_005690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CG478_005695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG478_005715	COG5506	Protein of unknown function (DUF1694)
CG478_005720	COG1253	flavin adenine dinucleotide binding
CG478_005730	COG1151	hydroxylamine reductase activity
CG478_005785	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CG478_005795	COG1070	Carbohydrate kinase
CG478_005800	COG1737	Transcriptional regulator
CG478_005810	COG0071	Belongs to the small heat shock protein (HSP20) family
CG478_005830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG478_005845	COG0367	asparagine synthase
CG478_005850	COG0071	Belongs to the small heat shock protein (HSP20) family
CG478_005855	COG1999	signal sequence binding
CG478_005865	COG1307	EDD domain protein, DegV family
CG478_005875	COG0805	protein transport
CG478_005880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CG478_005885	COG1272	protein, Hemolysin III
CG478_005890	COG0204	Acyl-transferase
CG478_005900	COG0768	penicillin binding
CG478_005910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CG478_005915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG478_005930	COG4473	ABC transporter
CG478_005935	COG1131	(ABC) transporter
CG478_005945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CG478_005950	COG0456	acetyltransferase
CG478_005960	COG2610	gluconate transmembrane transporter activity
CG478_005980	COG0477	Major facilitator Superfamily
CG478_005985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG478_006010	COG0733	neurotransmitter:sodium symporter activity
CG478_006020	COG0018	arginyl-trna synthetase
CG478_006025	COG2521	methyltransferase
CG478_006025	COG2136	Putative SAM-dependent methyltransferase
CG478_006040	COG1413	lyase activity
CG478_006045	COG0629	single-stranded DNA binding
CG478_006055	COG0488	(ABC) transporter
CG478_006060	COG1418	mRNA catabolic process
CG478_006105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG478_006110	COG0798	PFAM Bile acid sodium symporter
CG478_006115	COG0640	Transcriptional regulator
CG478_006150	COG0386	Belongs to the glutathione peroxidase family
CG478_006175	COG2226	methyltransferase
CG478_006200	COG3874	Sporulation protein YtfJ
CG478_006255	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG478_006305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG478_006310	COG1819	glycosyl
CG478_006315	COG1819	glycosyl
CG478_006320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CG478_006370	COG1876	peptidase activity
CG478_006380	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG478_006400	COG1114	Component of the transport system for branched-chain amino acids
CG478_006415	COG1253	flavin adenine dinucleotide binding
CG478_006420	COG2839	Protein conserved in bacteria
CG478_006430	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_006440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG478_006450	COG1607	acyl-coa hydrolase
CG478_006455	COG3689	TIGRFAM TIGR03943 family protein
CG478_006460	COG0701	Predicted permease
CG478_006470	COG2244	polysaccharide biosynthetic process
CG478_006475	COG0586	Pfam SNARE associated Golgi protein
CG478_006480	COG1051	belongs to the nudix hydrolase family
CG478_006485	COG5337	Spore coat protein CotH
CG478_006495	COG0346	lactoylglutathione lyase activity
CG478_006500	COG4166	transmembrane transport
CG478_006510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CG478_006515	COG1902	pentaerythritol trinitrate reductase activity
CG478_006530	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG478_006540	COG0523	cobalamin synthesis protein
CG478_006560	COG0783	Belongs to the Dps family
CG478_006565	COG3949	Membrane
CG478_006580	COG0840	transmembrane signaling receptor activity
CG478_006595	COG1404	Belongs to the peptidase S8 family
CG478_006600	COG2409	Drug exporters of the RND superfamily
CG478_006605	COG0577	efflux transmembrane transporter activity
CG478_006610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CG478_006630	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG478_006645	COG1247	-acetyltransferase
CG478_006650	COG1285	pathogenesis
CG478_006660	COG0726	polysaccharide deacetylase
CG478_006665	COG1316	TRANSCRIPTIONal
CG478_006670	COG0083	homoserine kinase activity
CG478_006680	COG0460	homoserine dehydrogenase
CG478_006690	COG0300	oxidoreductase activity
CG478_006695	COG1388	LysM domain
CG478_006695	COG0791	NLP P60 protein
CG478_006710	COG1686	Belongs to the peptidase S11 family
CG478_006735	COG0523	cobalamin synthesis protein
CG478_006740	COG0039	L-malate dehydrogenase activity
CG478_006745	COG0628	permease
CG478_006760	COG1012	belongs to the aldehyde dehydrogenase family
CG478_006775	COG1454	alcohol dehydrogenase
CG478_006785	COG1510	regulation of RNA biosynthetic process
CG478_006810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CG478_006815	COG2390	Transcriptional regulator
CG478_006825	COG0083	homoserine kinase activity
CG478_006840	COG1914	H( )-stimulated, divalent metal cation uptake system
CG478_006850	COG4166	transmembrane transport
CG478_006855	COG0402	S-adenosylhomocysteine deaminase activity
CG478_006875	COG3384	dioxygenase
CG478_006880	COG2814	Major facilitator Superfamily
CG478_006885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG478_006915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CG478_006920	COG0129	dihydroxy-acid dehydratase activity
CG478_006930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG478_006935	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG478_006950	COG5566	PFAM Mor transcription activator
CG478_006955	COG0733	neurotransmitter:sodium symporter activity
CG478_006960	COG2244	polysaccharide biosynthetic process
CG478_006965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG478_006970	COG2223	nitrite transmembrane transporter activity
CG478_006975	COG4166	transmembrane transport
CG478_006985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG478_007015	COG0109	protoheme IX farnesyltransferase activity
CG478_007025	COG2502	aspartate--ammonia ligase
CG478_007040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG478_007045	COG1280	lysine exporter protein (LysE YggA)
CG478_007055	COG2733	membrane
CG478_007060	COG3340	Belongs to the peptidase S51 family
CG478_007065	COG0534	Mate efflux family protein
CG478_007090	COG0114	fumarate hydratase activity
CG478_007100	COG1757	Na H antiporter
CG478_007110	COG0697	spore germination
CG478_007115	COG1802	Transcriptional regulator
CG478_007135	COG0367	asparagine synthase
CG478_007170	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_007180	COG2814	Major facilitator Superfamily
CG478_007230	COG0577	efflux transmembrane transporter activity
CG478_007230	COG1136	(ABC) transporter
CG478_007235	COG4786	Flagellar basal body rod
CG478_007240	COG1419	protein localization to endoplasmic reticulum
CG478_007245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG478_007250	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG478_007260	COG1987	bacterial-type flagellum assembly
CG478_007265	COG1338	Plays a role in the flagellum-specific transport system
CG478_007275	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG478_007275	COG1776	CheC inhibitor of MCP methylation
CG478_007280	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG478_007290	COG0741	lytic transglycosylase activity
CG478_007295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG478_007300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG478_007310	COG0784	Response regulator, receiver
CG478_007310	COG0835	chemotaxis
CG478_007345	COG1157	protein secretion by the type III secretion system
CG478_007355	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG478_007365	COG1677	Flagellar hook-basal body complex protein FliE
CG478_007370	COG1558	bacterial-type flagellum-dependent cell motility
CG478_007375	COG1815	bacterial-type flagellum-dependent cell motility
CG478_007390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CG478_007395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG478_007400	COG1256	bacterial-type flagellum assembly
CG478_007420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CG478_007435	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG478_007435	COG1776	CheC inhibitor of MCP methylation
CG478_007440	COG2198	Histidine kinase
CG478_007440	COG0643	Histidine kinase
CG478_007445	COG2201	protein-glutamate methylesterase activity
CG478_007455	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG478_007480	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CG478_007485	COG2323	membrane
CG478_007510	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG478_007515	COG0475	glutathione-regulated potassium exporter activity
CG478_007520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG478_007530	COG3162	membrane
CG478_007540	COG1278	Cold shock
CG478_007570	COG0328	RNA-DNA hybrid ribonuclease activity
CG478_007590	COG1733	regulation of RNA biosynthetic process
CG478_007595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG478_007600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG478_007605	COG3766	membrane
CG478_007645	COG0456	acetyltransferase
CG478_007655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG478_007660	COG2311	Membrane
CG478_007665	COG2233	PERMEase
CG478_007670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG478_007675	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CG478_007680	COG1199	ATP-dependent helicase activity
CG478_007690	COG0116	Belongs to the methyltransferase superfamily
CG478_007700	COG3599	regulation of cell shape
CG478_007705	COG4474	Belongs to the UPF0398 family
CG478_007740	COG3331	DNA recombination
CG478_007745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG478_007745	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG478_007755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CG478_007760	COG3935	DnaD domain protein
CG478_007780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CG478_007780	COG1199	ATP-dependent helicase activity
CG478_007785	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CG478_007790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CG478_007795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CG478_007810	COG0617	tRNA 3'-terminal CCA addition
CG478_007815	COG0438	transferase activity, transferring glycosyl groups
CG478_007820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG478_007825	COG1803	Methylglyoxal synthase
CG478_007830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CG478_007835	COG1694	Mazg nucleotide pyrophosphohydrolase
CG478_007840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG478_007850	COG2738	Putative neutral zinc metallopeptidase
CG478_007865	COG4347	Protein of unknown function (DUF1405)
CG478_007875	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CG478_007890	COG5582	Belongs to the UPF0302 family
CG478_007895	COG0457	Tetratricopeptide repeat
CG478_007900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CG478_007905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CG478_007910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CG478_007915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CG478_007920	COG0105	UTP biosynthetic process
CG478_007925	COG0142	geranyltranstransferase activity
CG478_007930	COG2226	methyltransferase
CG478_007935	COG0142	geranyltranstransferase activity
CG478_007940	COG0302	gtp cyclohydrolase
CG478_007950	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG478_007970	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CG478_007975	COG1160	GTP binding
CG478_008000	COG1304	FMN binding
CG478_008010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CG478_008025	COG0492	ferredoxin-NADP+ reductase activity
CG478_008040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG478_008055	COG1408	metallophosphoesterase
CG478_008065	COG1266	CAAX protease self-immunity
CG478_008070	COG0514	ATP-dependent DNA helicase (RecQ)
CG478_008080	COG1141	Ferredoxin
CG478_008085	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CG478_008100	COG2096	Adenosyltransferase
CG478_008105	COG5002	protein histidine kinase activity
CG478_008110	COG0745	RESPONSE REGULATOR receiver
CG478_008115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG478_008120	COG1333	cytochrome c biogenesis protein
CG478_008130	COG1187	pseudouridine synthase activity
CG478_008135	COG0700	Nucleoside recognition
CG478_008140	COG2715	membrane protein required for spore maturation
CG478_008145	COG1686	Belongs to the peptidase S11 family
CG478_008150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG478_008165	COG0392	lysyltransferase activity
CG478_008165	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CG478_008175	COG0813	purine-nucleoside phosphorylase activity
CG478_008180	COG5002	protein histidine kinase activity
CG478_008185	COG0582	viral genome integration into host DNA
CG478_008195	COG1801	Protein of unknown function DUF72
CG478_008200	COG3852	Histidine kinase
CG478_008210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG478_008215	COG1392	Phosphate transport regulator
CG478_008220	COG0306	phosphate transporter
CG478_008225	COG0730	response to heat
CG478_008245	COG2801	Transposase and inactivated derivatives
CG478_008255	COG1482	cell wall glycoprotein biosynthetic process
CG478_008260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG478_008260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG478_008260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG478_008265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG478_008265	COG3711	transcriptional antiterminator
CG478_008280	COG2723	6-phospho-beta-galactosidase activity
CG478_008290	COG3711	transcriptional antiterminator
CG478_008320	COG4085	toxin activity
CG478_008320	COG1525	nuclease
CG478_008320	COG0737	Belongs to the 5'-nucleotidase family
CG478_008325	COG1114	Component of the transport system for branched-chain amino acids
CG478_008330	COG2197	response regulator
CG478_008335	COG4585	Histidine kinase
CG478_008340	COG4758	membrane
CG478_008355	COG1757	Na H antiporter
CG478_008360	COG3557	Belongs to the UPF0374 family
CG478_008375	COG0733	neurotransmitter:sodium symporter activity
CG478_008380	COG1648	precorrin-2 dehydrogenase activity
CG478_008380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG478_008400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG478_008405	COG0529	Catalyzes the synthesis of activated sulfate
CG478_008410	COG2046	Belongs to the sulfate adenylyltransferase family
CG478_008415	COG0175	sulfate reduction
CG478_008425	COG0019	diaminopimelate decarboxylase activity
CG478_008435	COG1368	sulfuric ester hydrolase activity
CG478_008440	COG1183	phosphatidylcholine synthase activity
CG478_008455	COG0140	phosphoribosyl-ATP diphosphatase activity
CG478_008460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CG478_008465	COG0107	imidazoleglycerol-phosphate synthase activity
CG478_008475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CG478_008480	COG0131	Imidazoleglycerol-phosphate dehydratase
CG478_008490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CG478_008500	COG0066	3-isopropylmalate dehydratase activity
CG478_008505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CG478_008515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG478_008520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CG478_008525	COG0440	acetolactate synthase activity
CG478_008530	COG0028	Belongs to the TPP enzyme family
CG478_008560	COG3874	Sporulation protein YtfJ
CG478_008570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG478_008575	COG1301	dicarboxylic acid transport
CG478_008585	COG1846	Transcriptional regulator
CG478_008600	COG0534	Mate efflux family protein
CG478_008605	COG0288	reversible hydration of carbon dioxide
CG478_008610	COG3002	Belongs to the UPF0753 family
CG478_008615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG478_008620	COG5609	conserved protein (DUF2294)
CG478_008635	COG3173	Aminoglycoside phosphotransferase
CG478_008645	COG1368	sulfuric ester hydrolase activity
CG478_008670	COG0716	FMN binding
CG478_008685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG478_008690	COG1696	Membrane protein involved in D-alanine export
CG478_008700	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CG478_008705	COG2070	2-Nitropropane dioxygenase
CG478_008710	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG478_008725	COG1522	sequence-specific DNA binding
CG478_008740	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG478_008745	COG1131	(ABC) transporter
CG478_008755	COG1131	(ABC) transporter
CG478_008760	COG1725	Transcriptional regulator
CG478_008765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CG478_008780	COG1780	Probably involved in ribonucleotide reductase function
CG478_008800	COG0456	acetyltransferase
CG478_008810	COG4873	Protein conserved in bacteria
CG478_008815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CG478_008825	COG0720	synthase
CG478_008830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CG478_008850	COG1846	Transcriptional regulator
CG478_008855	COG3852	Histidine kinase
CG478_008865	COG2861	carbohydrate metabolic process
CG478_008875	COG0235	Class ii aldolase
CG478_008880	COG1349	DNA-binding transcription factor activity
CG478_008885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CG478_008890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG478_008900	COG3842	ATPase activity
CG478_008905	COG1840	ABC-type Fe3 transport system, periplasmic component
CG478_008920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG478_008925	COG3243	poly(R)-hydroxyalkanoic acid synthase
CG478_008930	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_008950	COG2030	dehydratase
CG478_008960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG478_008965	COG0861	Integral membrane protein TerC family
CG478_008970	COG2116	formate transmembrane transporter activity
CG478_009000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG478_009005	COG2267	carboxylic ester hydrolase activity
CG478_009015	COG0584	glycerophosphoryl diester phosphodiesterase
CG478_009020	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CG478_009025	COG1556	Lactate utilization protein
CG478_009030	COG1139	Iron-sulfur cluster binding protein
CG478_009035	COG0247	lactate metabolic process
CG478_009040	COG2186	Transcriptional regulator
CG478_009045	COG5002	protein histidine kinase activity
CG478_009050	COG0745	RESPONSE REGULATOR receiver
CG478_009060	COG3835	regulator
CG478_009065	COG0277	FAD linked oxidase domain protein
CG478_009070	COG0247	lactate metabolic process
CG478_009075	COG2340	Cysteine-rich secretory protein family
CG478_009085	COG0564	pseudouridine synthase activity
CG478_009095	COG2409	Drug exporters of the RND superfamily
CG478_009100	COG0671	phosphoesterase, PA-phosphatase related
CG478_009105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CG478_009110	COG1177	transmembrane transport
CG478_009115	COG1176	ABC-type spermidine putrescine transport system, permease component I
CG478_009125	COG1012	belongs to the aldehyde dehydrogenase family
CG478_009160	COG0681	Belongs to the peptidase S26 family
CG478_009165	COG1686	Belongs to the peptidase S11 family
CG478_009190	COG0582	viral genome integration into host DNA
CG478_009240	COG0582	viral genome integration into host DNA
CG478_009245	COG0457	Tetratricopeptide repeat
CG478_009275	COG0673	inositol 2-dehydrogenase activity
CG478_009340	COG0457	Tetratricopeptide repeat
CG478_009355	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG478_009360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG478_009365	COG3162	membrane
CG478_009370	COG0196	riboflavin kinase activity
CG478_009385	COG1012	belongs to the aldehyde dehydrogenase family
CG478_009390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG478_009395	COG0583	DNA-binding transcription factor activity
CG478_009405	COG0567	Dehydrogenase, E1 component
CG478_009410	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG478_009450	COG5634	Uncharacterized conserved protein (DUF2278)
CG478_009455	COG1620	l-lactate permease
CG478_009470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG478_009475	COG5492	domain, Protein
CG478_009490	COG2382	esterase
CG478_009495	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CG478_009520	COG1091	dTDP-4-dehydrorhamnose reductase activity
CG478_009535	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CG478_009555	COG0463	Glycosyl transferase, family 2
CG478_009555	COG0457	Tetratricopeptide repeat
CG478_009575	COG1216	Glycosyl transferase, family 2
CG478_009620	COG0772	Belongs to the SEDS family
CG478_009625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG478_009635	COG0564	pseudouridine synthase activity
CG478_009645	COG2357	RelA SpoT domain protein
CG478_009655	COG4116	CYTH
CG478_009660	COG2346	COG2346, Truncated hemoglobins
CG478_009675	COG1164	Oligoendopeptidase f
CG478_009695	COG0861	Integral membrane protein TerC family
CG478_009700	COG1393	Belongs to the ArsC family
CG478_009720	COG4166	transmembrane transport
CG478_009725	COG0534	Mate efflux family protein
CG478_009730	COG4608	Belongs to the ABC transporter superfamily
CG478_009735	COG0444	Belongs to the ABC transporter superfamily
CG478_009740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG478_009745	COG0601	transmembrane transport
CG478_009750	COG4166	transmembrane transport
CG478_009765	COG0180	Tryptophanyl-tRNA synthetase
CG478_009775	COG5504	Zn-dependent protease
CG478_009780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CG478_009785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG478_009800	COG2267	carboxylic ester hydrolase activity
CG478_009825	COG0561	phosphatase activity
CG478_009840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG478_009855	COG2996	Protein conserved in bacteria
CG478_009860	COG1666	GTP binding
CG478_009865	COG0366	Alpha amylase catalytic
CG478_009865	COG1874	Beta-galactosidase
CG478_009875	COG0753	catalase activity
CG478_009885	COG0367	asparagine synthase
CG478_009905	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG478_009945	COG1074	ATP-dependent DNA helicase activity
CG478_009950	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CG478_009960	COG0398	Pfam SNARE associated Golgi protein
CG478_009970	COG4903	ComK protein
CG478_009975	COG1278	Cold shock
CG478_009980	COG2224	Isocitrate lyase
CG478_009985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CG478_010000	COG0697	spore germination
CG478_010005	COG0840	transmembrane signaling receptor activity
CG478_010010	COG0501	Belongs to the peptidase M48B family
CG478_010030	COG0745	RESPONSE REGULATOR receiver
CG478_010035	COG2205	protein histidine kinase activity
CG478_010050	COG0318	PFAM AMP-dependent synthetase and ligase
CG478_010060	COG0095	Lipoate-protein ligase
CG478_010065	COG1234	tRNA 3'-trailer cleavage
CG478_010075	COG1609	Transcriptional regulator
CG478_010085	COG1216	Glycosyl transferase, family 2
CG478_010085	COG0438	transferase activity, transferring glycosyl groups
CG478_010095	COG1309	transcriptional regulator
CG478_010135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CG478_010140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG478_010145	COG2329	Antibiotic biosynthesis monooxygenase
CG478_010155	COG3402	PFAM membrane-flanked domain
CG478_010175	COG4473	ABC transporter
CG478_010180	COG1131	(ABC) transporter
CG478_010185	COG0537	adenosine 5'-monophosphoramidase activity
CG478_010195	COG4980	gas vesicle protein
CG478_010200	COG1846	Transcriptional regulator
CG478_010220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CG478_010225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CG478_010230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG478_010235	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CG478_010250	COG1316	TRANSCRIPTIONal
CG478_010260	COG0745	RESPONSE REGULATOR receiver
CG478_010265	COG5002	protein histidine kinase activity
CG478_010270	COG1136	(ABC) transporter
CG478_010275	COG0577	efflux transmembrane transporter activity
CG478_010290	COG3481	metal-dependent phosphohydrolase, HD sub domain
CG478_010295	COG4717	serine-type aminopeptidase activity
CG478_010300	COG0420	3'-5' exonuclease activity
CG478_010330	COG0393	Putative heavy-metal-binding
CG478_010335	COG2376	Dihydroxyacetone kinase
CG478_010345	COG2723	6-phospho-beta-galactosidase activity
CG478_010350	COG1263	PTS System
CG478_010350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG478_010350	COG2190	(PTS) system
CG478_010355	COG3711	transcriptional antiterminator
CG478_010370	COG4641	Protein conserved in bacteria
CG478_010415	COG3246	L-lysine catabolic process to acetate
CG478_010430	COG1064	alcohol dehydrogenase
CG478_010440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG478_010450	COG0473	3-isopropylmalate dehydrogenase activity
CG478_010455	COG1012	belongs to the aldehyde dehydrogenase family
CG478_010460	COG4638	Rieske (2fe-2S)
CG478_010475	COG1061	Type III restriction enzyme res subunit
CG478_010490	COG0494	nUDIX hydrolase
CG478_010535	COG1131	(ABC) transporter
CG478_010580	COG1476	TRANSCRIPTIONal
CG478_010705	COG1115	amino acid carrier protein
CG478_010710	COG0772	Belongs to the SEDS family
CG478_010715	COG2239	Acts as a magnesium transporter
CG478_010730	COG1363	Peptidase, m42
CG478_010745	COG1024	Enoyl-CoA hydratase
CG478_010760	COG1696	Membrane protein involved in D-alanine export
CG478_010780	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG478_010790	COG2244	polysaccharide biosynthetic process
CG478_010815	COG0318	PFAM AMP-dependent synthetase and ligase
CG478_010820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG478_010830	COG0561	phosphatase activity
CG478_010835	COG2094	Belongs to the DNA glycosylase MPG family
CG478_010895	COG2197	response regulator
CG478_010900	COG4585	Histidine kinase
CG478_010905	COG3679	Belongs to the UPF0342 family
CG478_010910	COG4399	Belongs to the UPF0754 family
CG478_010915	COG0189	ligase activity
CG478_010930	COG1126	abc transporter atp-binding protein
CG478_010935	COG0765	amino acid transport
CG478_010940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG478_010950	COG1132	(ABC) transporter
CG478_010955	COG1132	(ABC) transporter
CG478_010960	COG1012	belongs to the aldehyde dehydrogenase family
CG478_010970	COG0531	amino acid
CG478_010985	COG1522	sequence-specific DNA binding
CG478_011030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG478_011030	COG1263	PTS System
CG478_011035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CG478_011045	COG1737	Transcriptional regulator
CG478_011050	COG0475	glutathione-regulated potassium exporter activity
CG478_011105	COG3546	catalase activity
CG478_011110	COG1114	Component of the transport system for branched-chain amino acids
CG478_011120	COG1136	(ABC) transporter
CG478_011125	COG0577	efflux transmembrane transporter activity
CG478_011140	COG1283	sodium-dependent phosphate transmembrane transporter activity
CG478_011145	COG1316	TRANSCRIPTIONal
CG478_011155	COG2719	SpoVR family
CG478_011165	COG0778	Nitroreductase
CG478_011195	COG1316	TRANSCRIPTIONal
CG478_011220	COG1376	ErfK ybiS ycfS ynhG family protein
CG478_011225	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_011230	COG2252	PERMEase
CG478_011240	COG1846	Transcriptional regulator
CG478_011265	COG0735	belongs to the Fur family
CG478_011285	COG4974	Belongs to the 'phage' integrase family
CG478_011295	COG2205	protein histidine kinase activity
CG478_011300	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CG478_011305	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CG478_011335	COG0351	phosphomethylpyrimidine kinase
CG478_011340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG478_011345	COG2022	thiamine diphosphate biosynthetic process
CG478_011350	COG2104	thiamine diphosphate biosynthetic process
CG478_011355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG478_011360	COG0352	thiamine-phosphate diphosphorylase activity
CG478_011365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG478_011370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG478_011375	COG1116	anion transmembrane transporter activity
CG478_011380	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG478_011405	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CG478_011490	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG478_011530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG478_011535	COG0581	inorganic phosphate transmembrane transporter activity
CG478_011540	COG0573	inorganic phosphate transmembrane transporter activity
CG478_011545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG478_011550	COG1918	ferrous iron import across plasma membrane
CG478_011550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG478_011555	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG478_011560	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG478_011575	COG0531	amino acid
CG478_011580	COG0697	spore germination
CG478_011585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG478_011600	COG4990	cell redox homeostasis
CG478_011605	COG0833	amino acid
CG478_011610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CG478_011615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CG478_011630	COG0569	domain protein
CG478_011630	COG0475	glutathione-regulated potassium exporter activity
CG478_011640	COG2153	protein acetylation
CG478_011645	COG1113	amino acid transport
CG478_011655	COG1114	Component of the transport system for branched-chain amino acids
CG478_011685	COG1476	TRANSCRIPTIONal
CG478_011690	COG3583	domain protein
CG478_011690	COG3584	3D domain protein
CG478_011695	COG0840	transmembrane signaling receptor activity
CG478_011720	COG3568	Endonuclease Exonuclease Phosphatase
CG478_011760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CG478_011765	COG1879	ABC-type sugar transport system periplasmic component
CG478_011770	COG1172	Belongs to the binding-protein-dependent transport system permease family
CG478_011775	COG1129	ABC transporter
CG478_011780	COG1869	D-ribose catabolic process
CG478_011785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG478_011790	COG1609	Transcriptional regulator
CG478_011795	COG0477	Major facilitator Superfamily
CG478_011800	COG1846	Transcriptional regulator
CG478_011805	COG2271	Major facilitator Superfamily
CG478_011815	COG4608	Belongs to the ABC transporter superfamily
CG478_011820	COG0601	transmembrane transport
CG478_011830	COG0747	negative chemotaxis
CG478_011840	COG0589	response to stress
CG478_011845	COG0659	secondary active sulfate transmembrane transporter activity
CG478_011855	COG0745	RESPONSE REGULATOR receiver
CG478_011860	COG5002	protein histidine kinase activity
CG478_011870	COG0833	amino acid
CG478_011875	COG0765	amino acid transport
CG478_011880	COG0765	amino acid transport
CG478_011885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG478_011890	COG1126	abc transporter atp-binding protein
CG478_011900	COG1115	amino acid carrier protein
CG478_011905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG478_011910	COG0531	amino acid
CG478_011915	COG0714	Associated with various cellular activities
CG478_011920	COG4548	von Willebrand factor, type A
CG478_011935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG478_011940	COG0156	8-amino-7-oxononanoate synthase activity
CG478_011945	COG3104	oligopeptide transport
CG478_011965	COG1620	l-lactate permease
CG478_011970	COG1027	Aspartate ammonia-lyase
CG478_011975	COG1253	flavin adenine dinucleotide binding
CG478_011985	COG1316	TRANSCRIPTIONal
CG478_011990	COG2720	vancomycin resistance protein
CG478_012010	COG2217	Heavy metal translocating P-type atpase
CG478_012025	COG3227	Zinc metalloprotease (Elastase)
CG478_012035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CG478_012040	COG2217	Heavy metal translocating P-type atpase
CG478_012045	COG0640	Transcriptional regulator
CG478_012060	COG0531	amino acid
CG478_012070	COG0840	transmembrane signaling receptor activity
CG478_012080	COG2427	Protein of unknown function (DUF1641)
CG478_012085	COG3383	formate dehydrogenase (NAD+) activity
CG478_012090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CG478_012100	COG0745	RESPONSE REGULATOR receiver
CG478_012105	COG5002	protein histidine kinase activity
CG478_012120	COG0281	malic enzyme
CG478_012125	COG3493	citrate carrier protein
CG478_012130	COG4565	transcriptional regulatory protein
CG478_012135	COG3290	protein histidine kinase activity
CG478_012145	COG4990	cell redox homeostasis
CG478_012175	COG2268	Band 7 protein
CG478_012180	COG1585	Membrane protein implicated in regulation of membrane protease activity
CG478_012190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG478_012230	COG1280	lysine exporter protein (LysE YggA)
CG478_012255	COG2766	serine protein kinase
CG478_012265	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CG478_012285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CG478_012290	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CG478_012295	COG0217	transcriptional regulatory protein
CG478_012300	COG0457	Tetratricopeptide repeat
CG478_012320	COG3157	Type VI secretion system effector, Hcp
CG478_012420	COG0735	belongs to the Fur family
CG478_012425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CG478_012445	COG4555	ABC transporter
CG478_012450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG478_012455	COG0067	glutamate synthase
CG478_012455	COG0069	glutamate synthase activity
CG478_012455	COG0070	glutamate synthase
CG478_012460	COG4129	membrane
CG478_012465	COG1132	(ABC) transporter
CG478_012470	COG3557	Belongs to the UPF0374 family
CG478_012495	COG1194	a g-specific adenine glycosylase
CG478_012500	COG1988	membrane-bound metal-dependent
CG478_012525	COG2137	regulation of response to DNA damage stimulus
CG478_012530	COG0402	S-adenosylhomocysteine deaminase activity
CG478_012545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG478_012550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CG478_012560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG478_012560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG478_012570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG478_012575	COG1263	PTS System
CG478_012575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG478_012580	COG2066	Belongs to the glutaminase family
CG478_012610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG478_012635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG478_012660	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CG478_012680	COG0535	radical SAM domain protein
CG478_012690	COG0387	Pfam Sodium calcium exchanger
CG478_012705	COG0586	Pfam SNARE associated Golgi protein
CG478_012715	COG0681	Belongs to the peptidase S26 family
CG478_012725	COG0697	spore germination
CG478_012730	COG2217	Heavy metal translocating P-type atpase
CG478_012735	COG1295	ribonuclease BN
CG478_012745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG478_012750	COG4840	Belongs to the UPF0435 family
CG478_012760	COG3853	Toxic anion resistance protein (TelA)
CG478_012770	COG0861	Integral membrane protein TerC family
CG478_012775	COG2310	stress, protein
CG478_012780	COG2310	stress, protein
CG478_012785	COG2310	stress, protein
CG478_012810	COG2270	Major facilitator Superfamily
CG478_012815	COG2801	Transposase and inactivated derivatives
CG478_012820	COG2963	transposase activity
CG478_012900	COG1116	anion transmembrane transporter activity
CG478_012910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG478_012930	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CG478_012935	COG0352	thiamine-phosphate diphosphorylase activity
CG478_012940	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CG478_012945	COG4607	ABC-type enterochelin transport system periplasmic component
CG478_012950	COG4604	ABC transporter, ATP-binding protein
CG478_012955	COG4605	iron ion homeostasis
CG478_012960	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG478_012980	COG2190	(PTS) system
CG478_012980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG478_012980	COG1263	PTS System
CG478_012985	COG0366	Alpha amylase catalytic
CG478_013000	COG0549	Belongs to the carbamate kinase family
CG478_013015	COG2235	arginine
CG478_013030	COG0824	Thioesterase
CG478_013060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG478_013065	COG3655	Transcriptional regulator
CG478_013085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CG478_013095	COG0726	polysaccharide deacetylase
CG478_013125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG478_013130	COG0318	PFAM AMP-dependent synthetase and ligase
CG478_013160	COG0457	Tetratricopeptide repeat
CG478_013235	COG2826	transposase and inactivated derivatives, IS30 family
CG478_013250	COG0534	Mate efflux family protein
CG478_013280	COG3023	N-Acetylmuramoyl-L-alanine amidase
CG478_013290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG478_013300	COG5002	protein histidine kinase activity
CG478_013305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG478_013310	COG0010	Belongs to the arginase family
CG478_013315	COG1228	amidohydrolase
CG478_013320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CG478_013325	COG2986	histidine ammonia-lyase
CG478_013345	COG4846	Membrane protein involved in cytochrome C biogenesis
CG478_013350	COG0785	Cytochrome C biogenesis protein
CG478_013365	COG0583	DNA-binding transcription factor activity
CG478_013370	COG1380	Effector of murein hydrolase LrgA
CG478_013375	COG1346	cytolysis
CG478_013380	COG4187	Peptidase family M20/M25/M40
CG478_013390	COG0833	amino acid
CG478_013400	COG0730	response to heat
CG478_013410	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG478_013410	COG3409	Peptidoglycan-binding domain 1 protein
CG478_013425	COG1132	(ABC) transporter
CG478_013430	COG1132	(ABC) transporter
CG478_013435	COG3763	UPF0154 protein
CG478_013450	COG3639	organic phosphonate transmembrane transporter activity
CG478_013455	COG3639	organic phosphonate transmembrane transporter activity
CG478_013470	COG0737	Belongs to the 5'-nucleotidase family
CG478_013475	COG4224	UPF0291 protein
CG478_013480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG478_013485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CG478_013500	COG1695	Transcriptional regulator
CG478_013535	COG3328	transposase activity
CG478_013540	COG3328	transposase activity
CG478_013545	COG3328	transposase activity
CG478_013560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG478_013585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG478_013605	COG0730	response to heat
CG478_013660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG478_013730	COG3723	Recombinational DNA repair protein, rece pathway
CG478_013775	COG0582	viral genome integration into host DNA
CG478_013780	COG0174	glutamine synthetase
CG478_013785	COG0789	Transcriptional regulator
CG478_013790	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CG478_013795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG478_013800	COG2860	membrane
CG478_013805	COG0464	growth
CG478_013820	COG1923	regulation of RNA biosynthetic process
CG478_013825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CG478_013835	COG3584	3D domain protein
CG478_013835	COG1388	LysM domain
CG478_013840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG478_013840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG478_013840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG478_013845	COG1105	Belongs to the carbohydrate kinase PfkB family
CG478_013850	COG1349	DNA-binding transcription factor activity
CG478_013855	COG2322	membrane
CG478_013880	COG2116	formate transmembrane transporter activity
CG478_013890	COG1937	Protein conserved in bacteria
CG478_013895	COG2819	hydrolase of the alpha beta superfamily
CG478_013900	COG1120	ATPase activity
CG478_013905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG478_013910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG478_013915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG478_013920	COG2706	6-phosphogluconolactonase activity
CG478_013925	COG2826	transposase and inactivated derivatives, IS30 family
CG478_013930	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG478_013940	COG0346	lactoylglutathione lyase activity
CG478_013955	COG1113	amino acid transport
CG478_013980	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CG478_013985	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CG478_013995	COG4550	Control of competence regulator ComK, YlbF/YmcA
CG478_014000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG478_014005	COG1013	pyruvate-flavodoxin oxidoreductase activity
CG478_014010	COG0674	pyruvate-flavodoxin oxidoreductase activity
CG478_014010	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CG478_014020	COG2359	stage V sporulation protein S
CG478_014025	COG1692	metallophosphoesterase
CG478_014030	COG1418	mRNA catabolic process
CG478_014035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CG478_014040	COG1546	Belongs to the CinA family
CG478_014040	COG1058	Belongs to the CinA family
CG478_014045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG478_014050	COG1426	Protein conserved in bacteria
CG478_014065	COG0300	oxidoreductase activity
CG478_014070	COG0612	Peptidase, M16
CG478_014075	COG0612	Peptidase, M16
CG478_014100	COG2188	Transcriptional regulator
CG478_014120	COG0740	serine-type endopeptidase activity
CG478_014145	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG478_014160	COG0527	aspartate kinase activity
CG478_014165	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CG478_014170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG478_014175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG478_014180	COG1873	PFAM PRC-barrel domain
CG478_014185	COG0612	Peptidase, M16
CG478_014190	COG0726	polysaccharide deacetylase
CG478_014195	COG1185	polyribonucleotide nucleotidyltransferase activity
CG478_014205	COG0196	riboflavin kinase activity
CG478_014210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CG478_014215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CG478_014220	COG1550	Protein conserved in bacteria
CG478_014225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CG478_014230	COG1358	cellular component organization or biogenesis
CG478_014235	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CG478_014240	COG0195	Participates in both transcription termination and antitermination
CG478_014245	COG0779	Required for maturation of 30S ribosomal subunits
CG478_014255	COG0442	prolyl-tRNA aminoacylation
CG478_014260	COG0750	zinc metalloprotease
CG478_014270	COG4589	Belongs to the CDS family
CG478_014280	COG0233	cytoplasmic translational termination
CG478_014285	COG0528	UMP kinase activity
CG478_014290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CG478_014295	COG0052	Belongs to the universal ribosomal protein uS2 family
CG478_014300	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CG478_014305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CG478_014310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CG478_014315	COG4974	Belongs to the 'phage' integrase family
CG478_014320	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CG478_014325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG478_014330	COG0758	DNA mediated transformation
CG478_014335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CG478_014340	COG0045	succinate-CoA ligase (ADP-forming) activity
CG478_014345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG478_014360	COG0335	large ribosomal subunit rRNA binding
CG478_014370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CG478_014375	COG1837	Belongs to the UPF0109 family
CG478_014380	COG0228	four-way junction DNA binding
CG478_014385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CG478_014390	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CG478_014395	COG0552	protein localization to endoplasmic reticulum
CG478_014400	COG1196	nuclear chromosome segregation
CG478_014405	COG0571	ribonuclease III activity
CG478_014415	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_014420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CG478_014425	COG0416	fatty acid biosynthetic process
CG478_014430	COG2050	protein possibly involved in aromatic compounds catabolism
CG478_014430	COG1349	DNA-binding transcription factor activity
CG478_014435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CG478_014440	COG1461	Dihydroxyacetone kinase
CG478_014445	COG1302	Protein conserved in bacteria
CG478_014450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CG478_014460	COG1564	THIamine pyrophosphokinase
CG478_014465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CG478_014470	COG1162	GTPase activity
CG478_014475	COG0515	serine threonine protein kinase
CG478_014475	COG2815	serine threonine protein kinase
CG478_014480	COG0631	protein serine/threonine phosphatase activity
CG478_014485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CG478_014490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CG478_014490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG478_014495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG478_014500	COG0242	peptide deformylase activity
CG478_014505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CG478_014510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG478_014515	COG1758	RNA polymerase activity
CG478_014520	COG0194	GDP metabolic process
CG478_014530	COG1561	YicC-like family, N-terminal region
CG478_014535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG478_014560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CG478_014565	COG0284	orotidine-5'-phosphate decarboxylase activity
CG478_014570	COG0167	dihydroorotate dehydrogenase activity
CG478_014575	COG0543	2 iron, 2 sulfur cluster binding
CG478_014580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CG478_014590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CG478_014595	COG0540	Belongs to the ATCase OTCase family
CG478_014605	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CG478_014615	COG0564	pseudouridine synthase activity
CG478_014620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CG478_014630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CG478_014635	COG3599	regulation of cell shape
CG478_014640	COG2302	S4 RNA-binding domain
CG478_014645	COG0762	integral membrane protein
CG478_014650	COG1799	cell septum assembly
CG478_014655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CG478_014665	COG1873	PFAM PRC-barrel domain
CG478_014670	COG1191	sigma factor activity
CG478_014675	COG1191	sigma factor activity
CG478_014685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CG478_014690	COG0849	cell division
CG478_014695	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CG478_014705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG478_014710	COG0772	Belongs to the SEDS family
CG478_014715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CG478_014720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG478_014725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CG478_014730	COG0768	penicillin binding
CG478_014740	COG4839	cell division protein FtsL
CG478_014745	COG0275	rRNA processing
CG478_014750	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CG478_014755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CG478_014775	COG1399	metal-binding, possibly nucleic acid-binding protein
CG478_014885	COG4626	Terminase
CG478_014885	COG1802	Transcriptional regulator
CG478_014975	COG0756	dUTP diphosphatase activity
CG478_015005	COG3723	Recombinational DNA repair protein, rece pathway
CG478_015015	COG5377	YqaJ viral recombinase family
CG478_015060	COG0582	viral genome integration into host DNA
CG478_015065	COG1323	Belongs to the UPF0348 family
CG478_015070	COG3480	Lon protease (S16) C-terminal proteolytic domain
CG478_015075	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG478_015080	COG3314	Sporulation integral membrane protein YlbJ
CG478_015085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CG478_015090	COG0742	ribosomal rna small subunit methyltransferase
CG478_015100	COG4471	UPF0298 protein
CG478_015105	COG3679	Belongs to the UPF0342 family
CG478_015110	COG0406	alpha-ribazole phosphatase activity
CG478_015125	COG2340	Cysteine-rich secretory protein family
CG478_015135	COG3336	cytochrome c oxidase
CG478_015160	COG0109	protoheme IX farnesyltransferase activity
CG478_015165	COG1612	heme a metabolic process
CG478_015170	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CG478_015180	COG0772	Belongs to the SEDS family
CG478_015185	COG4838	Belongs to the UPF0358 family
CG478_015190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CG478_015195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CG478_015205	COG4896	Protein conserved in bacteria
CG478_015230	COG0483	inositol monophosphate 1-phosphatase activity
CG478_015240	COG4493	Belongs to the UPF0637 family
CG478_015245	COG4476	Belongs to the UPF0223 family
CG478_015250	COG1982	Orn Lys Arg decarboxylase major
CG478_015290	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG478_015300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG478_015315	COG0561	phosphatase activity
CG478_015330	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG478_015335	COG0569	domain protein
CG478_015345	COG1473	amidohydrolase
CG478_015350	COG2171	N-acyltransferase activity
CG478_015355	COG0583	DNA-binding transcription factor activity
CG478_015360	COG0517	IMP dehydrogenase activity
CG478_015370	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CG478_015390	COG4703	Protein of unknown function (DUF1797)
CG478_015405	COG2200	EAL domain
CG478_015410	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_015415	COG1408	metallophosphoesterase
CG478_015425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CG478_015465	COG2814	Major facilitator Superfamily
CG478_015470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CG478_015480	COG3209	COG3209 Rhs family protein
CG478_015490	COG2205	protein histidine kinase activity
CG478_015500	COG0436	Aminotransferase
CG478_015505	COG1609	Transcriptional regulator
CG478_015510	COG3833	ABC-type maltose transport systems, permease component
CG478_015515	COG1175	transmembrane transport
CG478_015520	COG2182	Extracellular solute-binding protein
CG478_015535	COG0366	Alpha amylase catalytic
CG478_015540	COG3842	ATPase activity
CG478_015570	COG0183	Belongs to the thiolase family
CG478_015600	COG1695	Transcriptional regulator
CG478_015605	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_015615	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CG478_015620	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CG478_015625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CG478_015630	COG0436	Aminotransferase
CG478_015635	COG1850	ribulose-bisphosphate carboxylase activity
CG478_015640	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CG478_015645	COG0235	Class ii aldolase
CG478_015650	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CG478_015665	COG2084	Dehydrogenase
CG478_015680	COG0778	Nitroreductase
CG478_015705	COG1263	PTS System
CG478_015705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG478_015705	COG2190	(PTS) system
CG478_015710	COG3711	transcriptional antiterminator
CG478_015725	COG0363	glucosamine-6-phosphate deaminase activity
CG478_015740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CG478_015745	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CG478_015755	COG1547	Domain of unknown function (DUF309)
CG478_015765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CG478_015770	COG4086	secreted protein
CG478_015775	COG0561	phosphatase activity
CG478_015780	COG0697	spore germination
CG478_015795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG478_015820	COG0733	neurotransmitter:sodium symporter activity
CG478_015830	COG2172	sigma factor antagonist activity
CG478_015840	COG1686	Belongs to the peptidase S11 family
CG478_015850	COG1725	Transcriptional regulator
CG478_015855	COG1131	(ABC) transporter
CG478_015880	COG1846	Transcriptional regulator
CG478_015895	COG0598	Magnesium transport protein CorA
CG478_015925	COG4974	Belongs to the 'phage' integrase family
CG478_015935	COG0735	belongs to the Fur family
CG478_015940	COG1300	Membrane
CG478_015960	COG0667	Aldo Keto reductase
CG478_015965	COG0656	L-ascorbic acid biosynthetic process
CG478_015970	COG0456	acetyltransferase
CG478_015970	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CG478_015980	COG0737	Belongs to the 5'-nucleotidase family
CG478_015980	COG4085	toxin activity
CG478_015980	COG1525	nuclease
CG478_015990	COG0596	Alpha beta hydrolase
CG478_015995	COG2056	Na+-H+ antiporter family
CG478_016000	COG1609	Transcriptional regulator
CG478_016005	COG0456	acetyltransferase
CG478_016010	COG1073	alpha beta
CG478_016025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG478_016025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG478_016030	COG0307	riboflavin synthase, alpha
CG478_016035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG478_016035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG478_016050	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CG478_016055	COG4106	trans-aconitate 2-methyltransferase activity
CG478_016060	COG0596	Alpha beta hydrolase
CG478_016065	COG0156	8-amino-7-oxononanoate synthase activity
CG478_016075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG478_016090	COG0737	Belongs to the 5'-nucleotidase family
CG478_016115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CG478_016125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CG478_016135	COG0300	oxidoreductase activity
CG478_016140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG478_016145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG478_016150	COG1760	l-serine dehydratase
CG478_016155	COG1760	l-serine dehydratase
CG478_016165	COG1234	tRNA 3'-trailer cleavage
CG478_016185	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG478_016190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG478_016205	COG1376	ErfK ybiS ycfS ynhG family protein
CG478_016210	COG4129	membrane
CG478_016215	COG1126	abc transporter atp-binding protein
CG478_016220	COG0765	amino acid transport
CG478_016225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG478_016240	COG2816	NAD+ diphosphatase activity
CG478_016245	COG0772	Belongs to the SEDS family
CG478_016255	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG478_016260	COG0022	dehydrogenase e1 component
CG478_016265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG478_016270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG478_016275	COG3426	butyrate kinase activity
CG478_016280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG478_016285	COG0280	phosphate acetyltransferase
CG478_016295	COG3290	protein histidine kinase activity
CG478_016295	COG3829	transcription factor binding
CG478_016305	COG0584	glycerophosphoryl diester phosphodiesterase
CG478_016310	COG3093	addiction module antidote protein HigA
CG478_016315	COG0745	RESPONSE REGULATOR receiver
CG478_016320	COG0750	zinc metalloprotease
CG478_016325	COG0497	DNA recombination
CG478_016335	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CG478_016340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CG478_016350	COG1722	exodeoxyribonuclease VII activity
CG478_016355	COG1570	exodeoxyribonuclease VII activity
CG478_016360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CG478_016365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG478_016370	COG1302	Protein conserved in bacteria
CG478_016375	COG0439	Biotin carboxylase
CG478_016380	COG0511	ligase activity, forming carbon-carbon bonds
CG478_016425	COG3854	ATPases associated with a variety of cellular activities
CG478_016445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CG478_016450	COG0006	proline dipeptidase activity
CG478_016455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CG478_016465	COG3872	metal-dependent enzyme
CG478_016475	COG1321	iron dependent repressor
CG478_016490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG478_016500	COG1609	Transcriptional regulator
CG478_016510	COG2076	Multidrug Resistance protein
CG478_016515	COG2076	Multidrug Resistance protein
CG478_016540	COG1131	(ABC) transporter
CG478_016545	COG1725	Transcriptional regulator
CG478_016560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG478_016565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG478_016570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CG478_016575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG478_016605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CG478_016630	COG1459	type II secretion system
CG478_016635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CG478_016670	COG1078	dGTPase activity
CG478_016685	COG1410	methionine synthase
CG478_016685	COG0646	methionine synthase
CG478_016690	COG0646	methionine synthase
CG478_016690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CG478_016695	COG0626	cystathionine gamma-synthase activity
CG478_016700	COG0626	cystathionine gamma-synthase activity
CG478_016720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG478_016730	COG1940	carbohydrate kinase activity
CG478_016735	COG4483	Protein conserved in bacteria
CG478_016740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CG478_016745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG478_016750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CG478_016755	COG0704	Plays a role in the regulation of phosphate uptake
CG478_016760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CG478_016765	COG0581	inorganic phosphate transmembrane transporter activity
CG478_016770	COG0573	inorganic phosphate transmembrane transporter activity
CG478_016775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG478_016785	COG0477	Major facilitator Superfamily
CG478_016790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG478_016810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CG478_016815	COG0735	belongs to the Fur family
CG478_016820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG478_016825	COG1121	(ABC) transporter
CG478_016830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG478_016840	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CG478_016855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CG478_016860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CG478_016865	COG2384	SAM-dependent methyltransferase
CG478_016875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CG478_016880	COG0358	DNA primase activity
CG478_016885	COG1671	Belongs to the UPF0178 family
CG478_016890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CG478_016895	COG0517	IMP dehydrogenase activity
CG478_016900	COG1381	Involved in DNA repair and RecF pathway recombination
CG478_016910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CG478_016920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CG478_016925	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CG478_016930	COG1480	7TM receptor with intracellular HD hydrolase
CG478_016935	COG1702	phosphate starvation-inducible protein PhoH
CG478_016950	COG1610	YqeY-like protein
CG478_016955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CG478_016960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG478_016965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CG478_016970	COG2264	protein methyltransferase activity
CG478_016975	COG0484	heat shock protein binding
CG478_016980	COG0443	Heat shock 70 kDa protein
CG478_016985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CG478_016990	COG1420	regulation of RNA biosynthetic process
CG478_016995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG478_017000	COG1733	regulation of RNA biosynthetic process
CG478_017005	COG0693	protein deglycase activity
CG478_017010	COG0481	GTPase activity
CG478_017025	COG0268	Binds directly to 16S ribosomal RNA
CG478_017030	COG1466	dna polymerase III delta subunit
CG478_017040	COG2333	competence protein COMEC
CG478_017040	COG0658	competence protein
CG478_017045	COG2131	deaminase
CG478_017050	COG1596	polysaccharide export
CG478_017050	COG1555	photosystem II stabilization
CG478_017055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG478_017060	COG2226	methyltransferase
CG478_017065	COG0799	negative regulation of ribosome biogenesis
CG478_017070	COG1713	HD superfamily hydrolase involved in NAD metabolism
CG478_017075	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CG478_017080	COG1534	Rna-binding protein
CG478_017085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CG478_017090	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CG478_017095	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CG478_017105	COG0688	phosphatidylethanolamine metabolic process
CG478_017110	COG1191	sigma factor activity
CG478_017120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG478_017125	COG2357	RelA SpoT domain protein
CG478_017130	COG1785	Belongs to the alkaline phosphatase family
CG478_017135	COG0456	acetyltransferase
CG478_017140	COG2267	carboxylic ester hydrolase activity
CG478_017165	COG3186	Phenylalanine-4-hydroxylase
CG478_017170	COG2154	pterin-4-alpha-carbinolamine dehydratase
CG478_017175	COG2514	catechol 2,3-dioxygenase activity
CG478_017180	COG2259	Doxx family
CG478_017195	COG1609	Transcriptional regulator
CG478_017205	COG0626	cystathionine gamma-synthase activity
CG478_017210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG478_017215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CG478_017220	COG2226	methyltransferase
CG478_017235	COG0768	penicillin binding
CG478_017245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CG478_017250	COG0572	uridine kinase
CG478_017270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CG478_017280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CG478_017285	COG4472	Bacterial protein of unknown function (DUF965)
CG478_017290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG478_017295	COG0628	permease
CG478_017315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CG478_017325	COG0482	sulfurtransferase activity
CG478_017330	COG1104	cysteine desulfurase activity
CG478_017335	COG1959	2 iron, 2 sulfur cluster binding
CG478_017340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CG478_017360	COG2207	Transcriptional regulator
CG478_017370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CG478_017375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CG478_017380	COG0124	histidyl-tRNA synthetase
CG478_017400	COG1490	D-aminoacyl-tRNA deacylase activity
CG478_017405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG478_017410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG478_017415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CG478_017415	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CG478_017420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG478_017425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG478_017425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG478_017435	COG2244	polysaccharide biosynthetic process
CG478_017460	COG1862	Preprotein translocase
CG478_017465	COG0343	queuine tRNA-ribosyltransferase activity
CG478_017470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CG478_017480	COG2255	four-way junction helicase activity
CG478_017485	COG0632	four-way junction helicase activity
CG478_017490	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CG478_017510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CG478_017515	COG0157	Belongs to the NadC ModD family
CG478_017520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CG478_017525	COG1104	cysteine desulfurase activity
CG478_017530	COG1827	regulation of RNA biosynthetic process
CG478_017535	COG2258	MOSC domain
CG478_017540	COG0077	Prephenate dehydratase
CG478_017545	COG0577	efflux transmembrane transporter activity
CG478_017550	COG0577	efflux transmembrane transporter activity
CG478_017555	COG1136	(ABC) transporter
CG478_017560	COG5002	protein histidine kinase activity
CG478_017565	COG0745	RESPONSE REGULATOR receiver
CG478_017575	COG3290	protein histidine kinase activity
CG478_017580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CG478_017585	COG2868	ribosomal protein
CG478_017595	COG1530	ribonuclease E activity
CG478_017600	COG1994	Peptidase M50
CG478_017605	COG0739	heme binding
CG478_017610	COG2894	cell division
CG478_017615	COG0850	regulation of cytokinetic process
CG478_017625	COG1792	Involved in formation and maintenance of cell shape
CG478_017630	COG1077	Cell shape determining protein MreB Mrl
CG478_017650	COG0424	maF-like protein
CG478_017660	COG0285	dihydrofolate synthase activity
CG478_017685	COG1388	LysM domain
CG478_017685	COG1388	LysM domain
CG478_017690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG478_017695	COG0113	porphobilinogen synthase activity
CG478_017700	COG1587	Uroporphyrinogen-III synthase
CG478_017705	COG0181	hydroxymethylbilane synthase activity
CG478_017710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG478_017715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CG478_017720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CG478_017730	COG1067	ATP-dependent peptidase activity
CG478_017730	COG0470	DNA polymerase III
CG478_017735	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CG478_017740	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG478_017765	COG4221	oxidoreductase activity
CG478_017765	COG3321	synthase
CG478_017765	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_017765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG478_017780	COG1033	growth of symbiont in host cell
CG478_017780	COG2409	Drug exporters of the RND superfamily
CG478_017790	COG1309	transcriptional regulator
CG478_017850	COG0622	Phosphoesterase
CG478_017860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CG478_017865	COG5401	PFAM Sporulation and spore germination
CG478_017875	COG2197	response regulator
CG478_017885	COG1959	2 iron, 2 sulfur cluster binding
CG478_017890	COG1668	transmembrane transport
CG478_017895	COG4152	abc transporter atp-binding protein
CG478_017900	COG1360	Flagellar Motor Protein
CG478_017905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG478_017915	COG1876	peptidase activity
CG478_017925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CG478_017930	COG1053	succinate dehydrogenase
CG478_017935	COG2009	succinate dehydrogenase
CG478_017940	COG1719	4-vinyl reductase, 4VR
CG478_017955	COG3118	belongs to the thioredoxin family
CG478_017960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CG478_017965	COG2086	electron transfer activity
CG478_017970	COG1024	Enoyl-CoA hydratase
CG478_017975	COG1309	transcriptional regulator
CG478_017980	COG0318	PFAM AMP-dependent synthetase and ligase
CG478_017990	COG2318	DinB family
CG478_018010	COG1131	(ABC) transporter
CG478_018015	COG2205	protein histidine kinase activity
CG478_018020	COG0745	RESPONSE REGULATOR receiver
CG478_018030	COG4895	conserved protein (DUF2196)
CG478_018035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CG478_018040	COG1114	Component of the transport system for branched-chain amino acids
CG478_018045	COG1187	pseudouridine synthase activity
CG478_018055	COG1193	negative regulation of DNA recombination
CG478_018060	COG1796	DNA polymerase
CG478_018060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CG478_018065	COG1286	toxin biosynthetic process
CG478_018070	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CG478_018095	COG0017	Asparaginyl-tRNA synthetase
CG478_018100	COG0072	phenylalanine-tRNA ligase activity
CG478_018100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG478_018105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CG478_018110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG478_018120	COG1418	mRNA catabolic process
CG478_018135	COG2814	Major facilitator Superfamily
CG478_018140	COG1566	PFAM secretion protein HlyD family protein
CG478_018145	COG1309	transcriptional regulator
CG478_018150	COG1363	Peptidase, m42
CG478_018160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CG478_018165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CG478_018170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CG478_018175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG478_018185	COG1484	DNA-dependent DNA replication
CG478_018190	COG3611	Membrane attachment protein
CG478_018195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CG478_018200	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CG478_018210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG478_018220	COG1971	Probably functions as a manganese efflux pump
CG478_018230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG478_018230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG478_018235	COG5002	protein histidine kinase activity
CG478_018240	COG0745	RESPONSE REGULATOR receiver
CG478_018250	COG0039	L-malate dehydrogenase activity
CG478_018255	COG0538	isocitrate dehydrogenase activity
CG478_018260	COG0372	Belongs to the citrate synthase family
CG478_018265	COG2707	UPF0756 membrane protein
CG478_018270	COG0628	permease
CG478_018275	COG3030	protein affecting phage T7 exclusion by the F plasmid
CG478_018285	COG0205	6-phosphofructokinase activity
CG478_018290	COG0825	malonyl-CoA metabolic process
CG478_018295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CG478_018300	COG1725	Transcriptional regulator
CG478_018305	COG0281	malic enzyme
CG478_018310	COG0587	DNA-directed DNA polymerase activity
CG478_018325	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CG478_018335	COG4109	DRTGG domain
CG478_018340	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CG478_018345	COG0006	proline dipeptidase activity
CG478_018370	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_018375	COG0589	response to stress
CG478_018400	COG0165	Argininosuccinate lyase
CG478_018405	COG0137	argininosuccinate synthase activity
CG478_018415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG478_018425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG478_018430	COG0827	DNA restriction-modification system
CG478_018435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CG478_018440	COG3874	Sporulation protein YtfJ
CG478_018450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CG478_018455	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CG478_018460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG478_018470	COG0301	tRNA thio-modification
CG478_018475	COG1104	cysteine desulfurase activity
CG478_018480	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CG478_018485	COG0583	DNA-binding transcription factor activity
CG478_018490	COG0697	spore germination
CG478_018495	COG1309	transcriptional regulator
CG478_018500	COG1956	GAF domain-containing protein
CG478_018505	COG0626	cystathionine gamma-synthase activity
CG478_018515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CG478_018540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CG478_018550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG478_018555	COG0454	-acetyltransferase
CG478_018560	COG0517	IMP dehydrogenase activity
CG478_018565	COG0123	including yeast histone deacetylase and acetoin utilization protein
CG478_018570	COG1970	mechanosensitive ion channel activity
CG478_018580	COG1609	Transcriptional regulator
CG478_018590	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG478_018590	COG1605	Chorismate mutase
CG478_018595	COG3118	belongs to the thioredoxin family
CG478_018605	COG2309	aminopeptidase activity
CG478_018620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CG478_018630	COG1674	ftsk spoiiie
CG478_018640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG478_018645	COG4848	Belongs to the UPF0354 family
CG478_018650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG478_018655	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CG478_018675	COG1363	Peptidase, m42
CG478_018685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG478_018690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CG478_018700	COG0510	thiamine kinase activity
CG478_018705	COG1523	belongs to the glycosyl hydrolase 13 family
CG478_018715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG478_018720	COG1349	DNA-binding transcription factor activity
CG478_018725	COG1187	pseudouridine synthase activity
CG478_018730	COG2244	polysaccharide biosynthetic process
CG478_018735	COG2081	HI0933 family
CG478_018740	COG2814	Major facilitator Superfamily
CG478_018750	COG3832	glyoxalase III activity
CG478_018770	COG1329	Transcriptional regulator
CG478_018780	COG2223	nitrite transmembrane transporter activity
CG478_018790	COG0314	molybdopterin synthase activity
CG478_018795	COG1763	Mo-molybdopterin cofactor biosynthetic process
CG478_018800	COG0303	'Molybdopterin
CG478_018805	COG0315	cyclic pyranopterin monophosphate synthase activity
CG478_018810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG478_018820	COG0303	'Molybdopterin
CG478_018825	COG0315	cyclic pyranopterin monophosphate synthase activity
CG478_018830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG478_018835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CG478_018840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG478_018845	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CG478_018850	COG1140	nitrate reductase beta subunit
CG478_018855	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CG478_018860	COG2181	nitrate reductase activity
CG478_018875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG478_018885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CG478_018920	COG0495	leucyl-tRNA aminoacylation
CG478_018925	COG2814	Major facilitator Superfamily
CG478_018935	COG1136	(ABC) transporter
CG478_018940	COG0346	lactoylglutathione lyase activity
CG478_018955	COG1242	4 iron, 4 sulfur cluster binding
CG478_018960	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CG478_018965	COG1121	(ABC) transporter
CG478_018975	COG1794	racemase activity, acting on amino acids and derivatives
CG478_018985	COG2378	regulation of single-species biofilm formation
CG478_018995	COG2267	carboxylic ester hydrolase activity
CG478_019010	COG0746	molybdenum cofactor guanylyltransferase activity
CG478_019035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CG478_019045	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CG478_019095	COG0800	Aldolase
CG478_019100	COG2610	gluconate transmembrane transporter activity
CG478_019105	COG1312	Catalyzes the dehydration of D-mannonate
CG478_019115	COG1414	Transcriptional regulator
CG478_019120	COG3409	Peptidoglycan-binding domain 1 protein
CG478_019120	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG478_019130	COG1368	sulfuric ester hydrolase activity
CG478_019145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG478_019150	COG1116	anion transmembrane transporter activity
CG478_019155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG478_019170	COG0494	nUDIX hydrolase
CG478_019180	COG1854	S-ribosylhomocysteine lyase activity
CG478_019185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CG478_019190	COG0288	reversible hydration of carbon dioxide
CG478_019195	COG1271	oxidase subunit
CG478_019200	COG1294	oxidase, subunit
CG478_019230	COG1842	Phage shock protein A
CG478_019275	COG1597	lipid kinase activity
CG478_019280	COG1136	(ABC) transporter
CG478_019290	COG0745	RESPONSE REGULATOR receiver
CG478_019295	COG2205	protein histidine kinase activity
CG478_019300	COG0577	efflux transmembrane transporter activity
CG478_019305	COG1136	(ABC) transporter
CG478_019325	COG4948	Mandelate Racemase Muconate Lactonizing
CG478_019330	COG0318	PFAM AMP-dependent synthetase and ligase
CG478_019335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CG478_019340	COG0596	Alpha beta hydrolase
CG478_019345	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CG478_019350	COG1169	isochorismate synthase
CG478_019355	COG1575	Belongs to the MenA family. Type 1 subfamily
CG478_019360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CG478_019365	COG1278	Cold shock
CG478_019385	COG0058	SHG alpha-glucan phosphorylase activity
CG478_019390	COG0297	glycogen (starch) synthase activity
CG478_019395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG478_019400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG478_019405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CG478_019410	COG0039	L-malate dehydrogenase activity
CG478_019505	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG478_019540	COG1285	pathogenesis
CG478_019545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG478_019555	COG0166	Belongs to the GPI family
CG478_019565	COG2155	Conserved Protein
CG478_019570	COG1098	S1 RNA binding domain
CG478_019575	COG0436	Aminotransferase
CG478_019580	COG1522	sequence-specific DNA binding
CG478_019585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG478_019590	COG2267	carboxylic ester hydrolase activity
CG478_019600	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CG478_019605	COG2032	superoxide dismutase activity
CG478_019615	COG5018	Exonuclease
CG478_019620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG478_019625	COG0423	glycine-tRNA ligase activity
CG478_019645	COG2050	protein possibly involved in aromatic compounds catabolism
CG478_019655	COG1268	BioY protein
CG478_019660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG478_019665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG478_019675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CG478_019685	COG3584	3D domain protein
CG478_019705	COG1252	NADH dehydrogenase
CG478_019710	COG0492	ferredoxin-NADP+ reductase activity
CG478_019725	COG1683	Conserved Protein
CG478_019760	COG1131	(ABC) transporter
CG478_019785	COG0316	Belongs to the HesB IscA family
CG478_019790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CG478_019795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG478_019805	COG1252	NADH dehydrogenase
CG478_019810	COG2824	Alkylphosphonate utilization operon protein PhnA
CG478_019820	COG3655	Transcriptional regulator
CG478_019835	COG4837	Protein of unknown function (DUF1462)
CG478_019840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CG478_019845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG478_019850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CG478_019855	COG0647	UMP catabolic process
CG478_019865	COG2445	Protein of unknown function DUF86
CG478_019870	COG1494	fructose-1,6-bisphosphatase
CG478_019880	COG4470	Protein conserved in bacteria
CG478_019890	COG0789	Transcriptional regulator
CG478_019895	COG4377	Putative membrane peptidase family (DUF2324)
CG478_019910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CG478_019915	COG0739	heme binding
CG478_019925	COG3377	Domain of unknown function (DUF1805)
CG478_019930	COG0737	Belongs to the 5'-nucleotidase family
CG478_019950	COG0719	Fe-S assembly protein
CG478_019955	COG0822	iron-sulfur transferase activity
CG478_019960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CG478_019965	COG0719	Fe-S assembly protein
CG478_019970	COG0396	ATPase activity
CG478_019975	COG1464	Belongs to the NlpA lipoprotein family
CG478_019980	COG2011	ABC-type metal ion transport system permease component
CG478_019995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG478_020000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CG478_020010	COG0509	glycine decarboxylation via glycine cleavage system
CG478_020015	COG1393	Belongs to the ArsC family
CG478_020055	COG1960	acyl-CoA dehydrogenase activity
CG478_020060	COG0183	Belongs to the thiolase family
CG478_020065	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG478_020065	COG1024	Enoyl-CoA hydratase
CG478_020075	COG1686	Belongs to the peptidase S11 family
CG478_020100	COG0011	TIGRFAM Protein of
CG478_020105	COG0840	transmembrane signaling receptor activity
CG478_020125	COG0531	amino acid
CG478_020130	COG0706	membrane insertase activity
CG478_020140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG478_020150	COG0586	Pfam SNARE associated Golgi protein
CG478_020160	COG1376	ErfK ybiS ycfS ynhG family protein
CG478_020165	COG0745	RESPONSE REGULATOR receiver
CG478_020170	COG5002	protein histidine kinase activity
CG478_020175	COG0840	transmembrane signaling receptor activity
CG478_020180	COG0840	transmembrane signaling receptor activity
CG478_020185	COG2151	metal-sulfur cluster biosynthetic enzyme
CG478_020190	COG3227	Zinc metalloprotease (Elastase)
CG478_020195	COG1741	Belongs to the pirin family
CG478_020210	COG0783	Belongs to the Dps family
CG478_020215	COG1611	Belongs to the LOG family
CG478_020235	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG478_020240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG478_020245	COG1121	(ABC) transporter
CG478_020265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG478_020270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG478_020275	COG1115	amino acid carrier protein
CG478_020280	COG2910	NAD(P)H-binding
CG478_020295	COG1252	NADH dehydrogenase
CG478_020310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG478_020325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG478_020330	COG4977	sequence-specific DNA binding
CG478_020330	COG1917	Cupin 2, conserved barrel domain protein
CG478_020335	COG3223	Belongs to the PsiE family
CG478_020340	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CG478_020360	COG0697	spore germination
CG478_020375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CG478_020380	COG0557	exoribonuclease II activity
CG478_020385	COG1647	Serine aminopeptidase, S33
CG478_020390	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CG478_020395	COG1346	cytolysis
CG478_020405	COG0148	phosphopyruvate hydratase activity
CG478_020410	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CG478_020415	COG0149	triose-phosphate isomerase activity
CG478_020420	COG0126	phosphoglycerate kinase activity
CG478_020425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG478_020440	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CG478_020490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG478_020505	COG2323	membrane
CG478_020515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG478_020520	COG1481	regulation of sporulation
CG478_020525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CG478_020530	COG1660	Displays ATPase and GTPase activities
CG478_020535	COG1051	belongs to the nudix hydrolase family
CG478_020545	COG0492	ferredoxin-NADP+ reductase activity
CG478_020550	COG0457	Tetratricopeptide repeat
CG478_020555	COG0110	maltose O-acetyltransferase activity
CG478_020565	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CG478_020570	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CG478_020575	COG1950	PFAM Membrane protein of
CG478_020585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CG478_020600	COG0789	Transcriptional regulator
CG478_020620	COG0583	DNA-binding transcription factor activity
CG478_020635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG478_020640	COG0793	Belongs to the peptidase S41A family
CG478_020640	COG3409	Peptidoglycan-binding domain 1 protein
CG478_020645	COG2177	Part of the ABC transporter FtsEX involved in
CG478_020650	COG2884	Cell division ATP-binding protein ftsE
CG478_020685	COG1278	Cold shock
CG478_020690	COG1040	competence protein
CG478_020695	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CG478_020700	COG1388	LysM domain
CG478_020700	COG0791	NLP P60 protein
CG478_020705	COG1733	regulation of RNA biosynthetic process
CG478_020710	COG1307	EDD domain protein, DegV family
CG478_020715	COG1739	Uncharacterized protein family UPF0029
CG478_020720	COG1316	TRANSCRIPTIONal
CG478_020730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CG478_020740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG478_020750	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CG478_020750	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CG478_020765	COG1486	melibiose metabolic process
CG478_020770	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG478_020785	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG478_020790	COG1301	dicarboxylic acid transport
CG478_020795	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CG478_020805	COG1271	oxidase subunit
CG478_020810	COG1294	oxidase, subunit
CG478_020815	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CG478_020820	COG1620	l-lactate permease
CG478_020825	COG2389	metal-binding protein
CG478_020835	COG1368	sulfuric ester hydrolase activity
CG478_020845	COG0791	NLP P60 protein
CG478_020845	COG1388	LysM domain
CG478_020850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG478_020860	COG1215	transferase activity, transferring glycosyl groups
CG478_020870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG478_020875	COG3584	3D domain protein
CG478_020875	COG1388	LysM domain
CG478_020890	COG4715	Zinc finger, swim domain protein
CG478_020895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG478_020935	COG0577	efflux transmembrane transporter activity
CG478_020940	COG1136	(ABC) transporter
CG478_020975	COG5002	protein histidine kinase activity
CG478_020975	COG3850	Histidine kinase
CG478_020980	COG0745	RESPONSE REGULATOR receiver
CG478_020990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG478_021000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG478_021000	COG1215	transferase activity, transferring glycosyl groups
CG478_021005	COG1134	teichoic acid transport
CG478_021010	COG1682	transport, permease protein
CG478_021015	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG478_021020	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG478_021020	COG0463	Glycosyl transferase, family 2
CG478_021025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG478_021030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CG478_021045	COG1609	Transcriptional regulator
CG478_021055	COG0739	heme binding
CG478_021070	COG3279	Response regulator of the LytR AlgR family
CG478_021075	COG2385	sporulation resulting in formation of a cellular spore
CG478_021090	COG4836	Membrane
CG478_021095	COG1007	ATP synthesis coupled electron transport
CG478_021100	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG478_021110	COG0713	ATP synthesis coupled electron transport
CG478_021115	COG0839	Belongs to the complex I subunit 6 family
CG478_021125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CG478_021130	COG0649	NAD binding
CG478_021135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG478_021140	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG478_021145	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG478_021150	COG3300	MHYT domain
CG478_021150	COG5001	Diguanylate cyclase
CG478_021155	COG3300	MHYT domain
CG478_021155	COG5001	Diguanylate cyclase
CG478_021170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CG478_021175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CG478_021185	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CG478_021190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CG478_021195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG478_021200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CG478_021205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG478_021230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CG478_021235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CG478_021245	COG0698	ribose 5-phosphate isomerase
CG478_021265	COG2190	(PTS) system
CG478_021270	COG2259	Doxx family
CG478_021275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CG478_021290	COG0009	L-threonylcarbamoyladenylate synthase
CG478_021305	COG2890	protein-(glutamine-N5) methyltransferase activity
CG478_021310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CG478_021315	COG1435	thymidine kinase activity
CG478_021325	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CG478_021330	COG1494	fructose-1,6-bisphosphatase
CG478_021350	COG4821	SIS domain
CG478_021355	COG0504	CTP synthase activity
CG478_021370	COG1960	acyl-CoA dehydrogenase activity
CG478_021375	COG1960	acyl-CoA dehydrogenase activity
CG478_021380	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG478_021385	COG0183	Belongs to the thiolase family
CG478_021390	COG0247	lactate metabolic process
CG478_021390	COG2181	nitrate reductase activity
CG478_021395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG478_021410	COG2197	response regulator
CG478_021415	COG4585	Histidine kinase
CG478_021420	COG0842	Transport permease protein
CG478_021425	COG1131	(ABC) transporter
CG478_021430	COG0024	Methionine aminopeptidase
CG478_021435	COG2234	aminopeptidase activity
CG478_021450	COG4506	Protein conserved in bacteria
CG478_021455	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG478_021470	COG0010	Belongs to the arginase family
CG478_021475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CG478_021480	COG2814	Major facilitator Superfamily
CG478_021485	COG0789	Transcriptional regulator
CG478_021490	COG0584	glycerophosphoryl diester phosphodiesterase
CG478_021495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG478_021505	COG1994	Peptidase M50
CG478_021515	COG1078	dGTPase activity
CG478_021520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG478_021525	COG1120	ATPase activity
CG478_021530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG478_021535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG478_021540	COG4844	belongs to the
CG478_021555	COG0280	phosphate acetyltransferase
CG478_021570	COG3773	Cell wall hydrolase
CG478_021580	COG2363	Small membrane protein
CG478_021590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG478_021595	COG2233	PERMEase
CG478_021600	COG0561	phosphatase activity
CG478_021605	COG2814	Major facilitator Superfamily
CG478_021610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CG478_021615	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG478_021620	COG1131	(ABC) transporter
CG478_021625	COG2755	lipolytic protein G-D-S-L family
CG478_021630	COG0460	homoserine dehydrogenase
CG478_021635	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CG478_021650	COG0351	phosphomethylpyrimidine kinase
CG478_021660	COG1966	Carbon starvation protein
CG478_021665	COG3279	Response regulator of the LytR AlgR family
CG478_021670	COG0477	Major facilitator Superfamily
CG478_021680	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CG478_021685	COG0438	transferase activity, transferring glycosyl groups
CG478_021700	COG0840	transmembrane signaling receptor activity
CG478_021715	COG1607	acyl-coa hydrolase
CG478_021720	COG1216	Glycosyl transferase, family 2
CG478_021735	COG0463	Glycosyl transferase, family 2
CG478_021750	COG0463	Glycosyl transferase, family 2
CG478_021755	COG0488	(ABC) transporter
CG478_021760	COG1309	transcriptional regulator
CG478_021765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG478_021770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG478_021770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG478_021775	COG0628	permease
CG478_021780	COG1346	cytolysis
CG478_021790	COG3279	Response regulator of the LytR AlgR family
CG478_021795	COG3275	phosphorelay sensor kinase activity
CG478_021800	COG2814	Major facilitator Superfamily
CG478_021805	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CG478_021810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG478_021820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG478_021825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG478_021825	COG3711	transcriptional antiterminator
CG478_021880	COG0582	viral genome integration into host DNA
CG478_021895	COG1132	(ABC) transporter
CG478_021905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CG478_021915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG478_021920	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CG478_021925	COG4853	Protein conserved in bacteria
CG478_021935	COG5002	protein histidine kinase activity
CG478_021940	COG0745	RESPONSE REGULATOR receiver
CG478_021965	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CG478_021970	COG0305	Participates in initiation and elongation during chromosome replication
CG478_021975	COG0359	binds to the 23S rRNA
CG478_021980	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CG478_021985	COG4241	membrane
CG478_021990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CG478_021995	COG0629	single-stranded DNA binding
CG478_022000	COG0360	Binds together with S18 to 16S ribosomal RNA
CG478_022005	COG0012	GTP binding
CG478_022010	COG4481	Protein conserved in bacteria
CG478_022015	COG0668	transmembrane transport
CG478_022025	COG1475	DNA binding
CG478_022030	COG1192	Involved in chromosome partitioning
CG478_022035	COG1475	DNA binding
CG478_022040	COG0357	Ribosomal RNA small subunit methyltransferase G
CG478_022045	COG0445	tRNA wobble uridine modification
CG478_022050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CG478_022055	COG1847	R3H domain protein
CG478_022060	COG0706	membrane insertase activity
CG478_022065	COG0594	ribonuclease P activity
CG478_022135	COG1028	Short-chain dehydrogenase reductase Sdr
CG478_022245	COG0791	NLP P60 protein
CG478_022245	COG0741	lytic transglycosylase activity
CG478_022395	COG1192	Involved in chromosome partitioning
CG478_022435	COG0457	Tetratricopeptide repeat
CG478_022445	COG4166	transmembrane transport
CG478_022480	COG4974	Belongs to the 'phage' integrase family