locus-tag class description FED53_00070 ENOG4107R3N Filamentation induced by cAMP protein fic FED53_00205 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FED53_00210 ENOG4108HGU Histidine kinase FED53_00290 ENOG4105K4H Nlp p60 protein FED53_00350 ENOG41062IR nudix hydrolase FED53_00355 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FED53_00385 ENOG4105C31 Tryptophanyl-tRNA synthetase FED53_00400 ENOG4105E2A Dehydrogenase FED53_00405 ENOG41080HJ 6-phospho 3-hexuloisomerase FED53_00410 ENOG4108VA3 3-hexulose-6-phosphate synthase FED53_00415 ENOG4105KVH Transcriptional regulator FED53_00420 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FED53_00440 ENOG4105DQ6 Transposase FED53_00460 ENOG4108VA3 3-hexulose-6-phosphate synthase FED53_00470 ENOG4105CHH sulfate transporter FED53_00475 ENOG4107YZX Universal stress protein FED53_00480 ENOG4105CN5 Metallo-Beta-Lactamase FED53_00585 ENOG4105YWU small acid-soluble spore protein FED53_00680 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FED53_00685 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FED53_00690 ENOG4105C6E dna polymerase iii FED53_00700 ENOG4108Z6B deaminase FED53_00705 ENOG4105GTG Isochorismatase FED53_00710 ENOG4105VRS hydrolase family 18 FED53_00720 ENOG4105ZMH deoxynucleoside kinase FED53_00730 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FED53_00735 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FED53_00740 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FED53_00750 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FED53_00785 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FED53_00790 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FED53_00795 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FED53_00800 ENOG410848D S4 domain protein YaaA FED53_00805 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FED53_00810 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FED53_00815 ENOG4105VG0 50S ribosomal protein l34 FED53_00820 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FED53_00825 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FED53_00835 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FED53_00840 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FED53_00850 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) FED53_00855 ENOG4107QJE Chromosome Partitioning Protein FED53_00865 ENOG4108ZDA Sporulation protein YyaC FED53_00875 ENOG4105D8X mechanosensitive ion channel FED53_00880 ENOG4105VDK protein, conserved in bacteria FED53_00885 ENOG4105C3G gtp-binding protein FED53_00895 ENOG4108UUM single-stranded DNA-binding protein FED53_00900 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FED53_00910 ENOG4105BZR domain protein FED53_00920 ENOG4105CDU Replicative dna helicase FED53_00925 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FED53_00950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FED53_00955 ENOG4105BZU Histidine kinase FED53_00970 ENOG4105Q2H domain protein FED53_00975 ENOG4105C0H protease FED53_01010 ENOG4105E2A Dehydrogenase FED53_01025 ENOG4105E1K spore germination protein FED53_01035 ENOG4105D8G Major Facilitator superfamily FED53_01040 ENOG4108Y4K DNA-binding transcriptional activator FED53_01050 ENOG4108UMI ABC transporter, permease FED53_01055 ENOG4105D01 (LipO)protein FED53_01065 ENOG4108JU3 Alkyl hydroperoxide reductase FED53_01070 ENOG4105D3R alkyl hydroperoxide reductase FED53_01075 ENOG4105C2F Histidine kinase FED53_01080 ENOG4108NEV two component transcriptional regulator, LytTR family FED53_01085 ENOG4107FKK extracellular solute-binding protein family 1 FED53_01090 ENOG4105EDQ levansucrase EC 2.4.1.10 FED53_01095 ENOG4108HKT sucrose-6-phosphate hydrolase FED53_01100 ENOG4105C1J atp-dependent rna helicase FED53_01115 ENOG4105DWK Membrane FED53_01120 ENOG4107XM3 UPF0442 protein FED53_01125 ENOG4107T7U Sulfatase FED53_01135 ENOG4105CJR Integral membrane protein (MviN FED53_01155 ENOG410838F Glycosyl transferase family 2 FED53_01160 ENOG4105CPK Glycosyl transferase (Group 1 FED53_01170 ENOG4105CI1 PTS System FED53_01175 ENOG4107URF beta-phospho-glucomutase FED53_01180 ENOG4105J7I hydrolase FED53_01185 ENOG4105DWF phosphomethylpyrimidine kinase FED53_01190 ENOG4105DCF alanine dehydrogenase FED53_01195 ENOG4108K8K Transcriptional regulator FED53_01200 ENOG4105BZG amino acid carrier protein FED53_01205 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FED53_01210 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FED53_01220 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FED53_01240 ENOG4108VKI Cell wall hydrolase FED53_01245 ENOG4107JTW chlorite dismutase FED53_01250 ENOG4108IJ2 phosphate acetyltransferase FED53_01260 ENOG4108VCI transcription factor, rsfa family FED53_01270 ENOG4105DCI Phosphohydrolase FED53_01280 ENOG41069HH 4-oxalocrotonate tautomerase FED53_01285 ENOG4108Z4T Peptidase M50 FED53_01290 ENOG4108XFG YwhD family FED53_01295 ENOG4105BZ4 penicillin-binding protein FED53_01300 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FED53_01305 ENOG4105CYW agmatinase FED53_01330 ENOG4105DF6 Fe-S oxidoreductase FED53_01340 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FED53_01345 ENOG4105C1G acyl-Coa dehydrogenase FED53_01350 ENOG4105C1G acyl-Coa dehydrogenase FED53_01360 ENOG4105D5P Methylmalonyl-coA mutase FED53_01370 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FED53_01380 ENOG410812K response regulator receiver protein FED53_01385 ENOG4105D2N Aldolase FED53_01390 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FED53_01395 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FED53_01400 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FED53_01405 ENOG4105VFB Binds the 23S rRNA (By similarity) FED53_01410 ENOG4107104 thymidine kinase FED53_01420 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FED53_01425 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FED53_01430 ENOG4108ZXQ stage ii sporulation protein r FED53_01440 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FED53_01455 ENOG4108YZG isomerase FED53_01465 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FED53_01470 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FED53_01475 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FED53_01480 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FED53_01490 ENOG41062M3 atp synthase FED53_01495 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FED53_01500 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FED53_01505 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FED53_01510 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FED53_01515 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FED53_01520 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FED53_01525 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FED53_01530 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FED53_01535 ENOG4106778 Protein of unknown function (DUF1146) FED53_01555 ENOG4105FRN stage II sporulation protein FED53_01560 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FED53_01575 ENOG4105CGA flagellar basal-body rod protein FlgG FED53_01595 ENOG4105Z8H single-stranded DNA-binding protein FED53_01605 ENOG4105C0D helicase FED53_01615 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FED53_01630 ENOG4105DZ6 Band 7 protein FED53_01640 ENOG4105ESV Glycosyl transferase, family 4 FED53_01645 ENOG4108KGH TRANSCRIPTIONal FED53_01650 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FED53_01655 ENOG4105BZU Histidine kinase FED53_01660 ENOG4105WH1 Two component transcriptional regulator luxr family FED53_01680 ENOG4105I03 Flagellin FED53_01685 ENOG4105XVJ Protein of unknown function (DUF327) FED53_01700 ENOG41081UC Inherit from COG: Competence protein FED53_01720 ENOG4105E1Q flagellar hook-associated protein FED53_01725 ENOG4105DTJ flagellar hook-associated protein FED53_01730 ENOG4105MKD FED53_01735 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) FED53_01740 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FED53_01745 ENOG4105I03 Flagellin FED53_01750 ENOG4105I03 Flagellin FED53_01770 ENOG4107RT6 flagellar hook-associated FED53_01775 ENOG4105MQ3 flagellar protein FliS FED53_01785 ENOG4105MS2 ribosomal subunit Interface protein FED53_01790 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FED53_01810 ENOG4105CAK Cell division ATP-binding protein ftsE FED53_01815 ENOG4105CRP Part of the ABC transporter FtsEX involved in FED53_01820 ENOG4105DR5 peptidase FED53_01825 ENOG4105CN1 protease FED53_01830 ENOG4105KVH Transcriptional regulator FED53_01835 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FED53_01840 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FED53_01855 ENOG4105C26 Dehydrogenase FED53_01860 ENOG4105CK7 Sodium proline symporter FED53_01875 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FED53_01880 ENOG4108PY7 FED53_01885 ENOG41067S9 phage shock protein C, PspC FED53_01890 ENOG41086DT Membrane protein of unknown function FED53_01895 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FED53_01900 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FED53_01905 ENOG4105HKU nucleoside recognition domain-containing protein FED53_01910 ENOG4107XGZ Hydrolase FED53_01915 ENOG4108S4C acetyltransferase FED53_01920 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FED53_01925 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FED53_01930 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FED53_01935 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FED53_01940 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FED53_01945 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FED53_01950 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FED53_01955 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FED53_01965 ENOG4105C3M thioredoxin reductase FED53_01970 ENOG4108Z4K mutator MutT protein FED53_01975 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FED53_01980 ENOG4105CHW UPF0052 protein FED53_01985 ENOG4105CIE May be required for sporulation (By similarity) FED53_01990 ENOG4105KRI phosphocarrier protein (HPr FED53_01995 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FED53_02010 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FED53_02050 ENOG4105XZU Preprotein translocase, subunit SecG FED53_02060 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FED53_02065 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FED53_02085 ENOG41079KZ Major Facilitator Superfamily FED53_02095 ENOG4108MES Periplasmic binding protein FED53_02100 ENOG4105DQ5 transport system permease protein FED53_02105 ENOG4108IHU transport system permease protein FED53_02110 ENOG4105E0A ABC, transporter FED53_02140 ENOG4105CHU acetyl-coa acetyltransferase FED53_02145 ENOG4105C1G acyl-Coa dehydrogenase FED53_02150 ENOG41080E8 Transcriptional regulator, Spx MgsR family FED53_02155 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FED53_02175 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FED53_02180 ENOG4108UMI ABC transporter, permease FED53_02185 ENOG4105D01 (LipO)protein FED53_02195 ENOG4105C3K feS assembly ATPase SufC FED53_02200 ENOG4105JRK feS assembly protein SufD FED53_02205 ENOG4105C9B Cysteine desulfurase FED53_02210 ENOG4108UNV SUF system FeS assembly protein, NifU family FED53_02215 ENOG4105DIW FeS assembly protein SUFB FED53_02220 ENOG4105I3N Conserved Protein FED53_02225 ENOG4105KZD Domain of unknown function (DUF1805) FED53_02230 ENOG4105CPI Metal Dependent Phosphohydrolase FED53_02245 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FED53_02255 ENOG4105VMP Transcriptional regulator FED53_02270 ENOG4108YTE sporulation protein YunB FED53_02275 ENOG4107S6Z Na H antiporter FED53_02280 ENOG4105C8J )-transporter FED53_02290 ENOG4105FAA peptidase M23 FED53_02300 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FED53_02305 ENOG4105MMD transcriptional regulator FED53_02320 ENOG4105D4U had-superfamily hydrolase, subfamily iia FED53_02325 ENOG4108W5N phosphatidylglycerophosphatase a FED53_02335 ENOG4105C5I Dehydrogenase FED53_02340 ENOG4105D6E homoserine dehydrogenase FED53_02345 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FED53_02350 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FED53_02355 ENOG41083MR nifu domain-containing protein FED53_02370 ENOG4105ZKE UPF0349 protein FED53_02385 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FED53_02400 ENOG4105CEP NADH dehydrogenase FED53_02410 ENOG41069ER domain protein FED53_02415 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FED53_02435 ENOG4105KA0 thioesterase Superfamily protein FED53_02445 ENOG4105Y38 Kinase-associated protein B FED53_02455 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FED53_02460 ENOG4105C87 Aminotransferase class I and II FED53_02465 ENOG4108MUZ hydrolase FED53_02470 ENOG4108ZB6 transcriptional regulator AsnC family FED53_02475 ENOG4105CHM Aminotransferase FED53_02485 ENOG4105WG9 Conserved Protein FED53_02490 ENOG4107QW4 alcohol dehydrogenase FED53_02495 ENOG4105KJM monovalent cation h antiporter subunit g FED53_02505 ENOG4105SC1 monovalent cation H antiporter subunit E FED53_02510 ENOG4108JPZ Monovalent cation H antiporter subunit D FED53_02515 ENOG4108ZE9 Monovalent cation H antiporter subunit C FED53_02520 ENOG4105HC0 Na H antiporter FED53_02525 ENOG4105D65 subunit l FED53_02535 ENOG4107QYV phosphohexose isomerase FED53_02545 ENOG4107PBV potassium channel FED53_02585 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FED53_02590 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FED53_02595 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FED53_02600 ENOG4108Z73 Siroheme synthase FED53_02605 ENOG4105KT7 mgtC SapB transporter FED53_02610 ENOG4105CEY Amp-dependent synthetase and ligase FED53_02740 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FED53_02765 ENOG4105E4F Isochorismate synthase FED53_02770 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FED53_02775 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FED53_02780 ENOG4108IPT Naphthoate synthase FED53_02785 ENOG4105CEY Amp-dependent synthetase and ligase FED53_02790 ENOG4105DTQ mandelate racemase muconate lactonizing FED53_02795 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FED53_02800 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FED53_02835 ENOG4105NRA 50s ribosomal protein l31 type b FED53_02840 ENOG4105DSE periplasmic solute binding protein FED53_02845 ENOG4105CKI cobalamin synthesis protein FED53_02850 ENOG4108V2W Carbonate dehydratase FED53_02855 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FED53_02860 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FED53_02870 ENOG4108RMU ferritin dps family protein FED53_02890 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FED53_02900 ENOG4105D2X ABC transporter substrate-binding protein FED53_02915 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FED53_02920 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FED53_02925 ENOG4105BZF Glycosyl transferase (Group 1 FED53_02935 ENOG4108Z0R Transferase FED53_02940 ENOG4105E8V Alpha Beta Hydrolase Fold protein FED53_02955 ENOG4105N5T Radical SAM Protein FED53_02970 ENOG410605W Major Facilitator FED53_02975 ENOG4105CY2 Citrate transporter FED53_02980 ENOG4105C8T Leucyl-tRNA synthetase FED53_02985 ENOG41085GJ domain protein FED53_02995 ENOG4105CBX hi0933 family FED53_03015 ENOG4105YW5 deoR family transcriptional regulator FED53_03020 ENOG4107QSE Dipeptidase FED53_03025 ENOG4105C6T cysteine synthase FED53_03035 ENOG4108IUM Glycogen debranching enzyme FED53_03040 ENOG4108V15 phosphotransferase enzyme family FED53_03050 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FED53_03055 ENOG4105C8F Beta-lactamase domain protein FED53_03080 ENOG4108NKM UPF0354 protein FED53_03085 ENOG4108VDD TRNA binding domain protein FED53_03100 ENOG4105DFU Cell wall formation (By similarity) FED53_03125 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FED53_03130 ENOG4105ETE Transcriptional regulator (LacI family FED53_03135 ENOG4105E14 MotA TolQ exbB proton channel FED53_03140 ENOG4106VK6 Flagellar motor protein FED53_03145 ENOG4105DGU Histone deacetylase FED53_03150 ENOG4105W87 Cbs domain FED53_03155 ENOG4105F1V Acetoin utilization protein FED53_03170 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FED53_03180 ENOG4105BZU Histidine kinase FED53_03190 ENOG4105U5Y Transcriptional regulator FED53_03195 ENOG4108W76 histidinol phosphate phosphatase hisj family FED53_03200 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) FED53_03215 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FED53_03225 ENOG4105EFZ amidohydrolase FED53_03230 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FED53_03235 ENOG4105D07 Signal peptide peptidase, SppA FED53_03240 ENOG4105VK3 rdd domain containing protein FED53_03250 ENOG4105KBJ sporulation protein ytfj FED53_03255 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FED53_03265 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FED53_03280 ENOG4105CDH Citrulline--aspartate ligase FED53_03285 ENOG4105CH7 arginosuccinase FED53_03295 ENOG4105E8R UPF0173 metal-dependent hydrolase FED53_03315 ENOG4105SFS phosphoesterase RecJ domain protein FED53_03325 ENOG4105VV2 FED53_03330 ENOG4105C0B DNA polymerase III (alpha subunit) FED53_03335 ENOG4105C6K Malic enzyme FED53_03340 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FED53_03345 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FED53_03350 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FED53_03355 ENOG4105CA9 Pyruvate kinase FED53_03360 ENOG4105FS0 cytoplasmic membrane protein FED53_03365 ENOG4108REF Sporulation integral membrane protein ytvi FED53_03370 ENOG4107CWS Protein of unknown function (DUF441) FED53_03375 ENOG4105BZN citrate synthase FED53_03380 ENOG4108HMX isocitrate dehydrogenase (NADP) FED53_03385 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FED53_03395 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FED53_03400 ENOG4105BZU Histidine kinase FED53_03405 ENOG4105C2M dna polymerase I FED53_03410 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FED53_03420 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FED53_03425 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FED53_03430 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FED53_03440 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FED53_03455 ENOG4108TDW sporulation protein YtxC FED53_03460 ENOG4105C22 threonyL-tRNA synthetase FED53_03465 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FED53_03470 ENOG4105VJV 50s ribosomal protein L35 FED53_03475 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FED53_03480 ENOG410696E Membrane FED53_03495 ENOG4105CN9 Peptidase m42 family protein FED53_03500 ENOG41067MF small acid-soluble spore protein FED53_03505 ENOG4108RWN rrna methyltransferase FED53_03510 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FED53_03515 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FED53_03520 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FED53_03525 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FED53_03535 ENOG4105DCG PHP domain protein FED53_03540 ENOG4105C98 muts2 protein FED53_03550 ENOG4105CEY Amp-dependent synthetase and ligase FED53_03555 ENOG4107Z3H Transcriptional regulator, TetR family FED53_03560 ENOG41060WC Enoyl-CoA hydratase FED53_03565 ENOG4105BZJ Electron transfer flavoprotein FED53_03570 ENOG4105C10 Electron transfer flavoprotein FED53_03575 ENOG4105K63 Thioredoxin FED53_03580 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FED53_03585 ENOG4105CFH Aspartokinase FED53_03595 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FED53_03605 ENOG4105E33 succinate dehydrogenase FED53_03610 ENOG4105PFC Transcriptional regulator FED53_03620 ENOG4105NCW Trka-c domain protein FED53_03625 ENOG4107S91 Sodium hydrogen exchanger FED53_03635 ENOG4107RVG penicillin-binding protein FED53_03640 ENOG4107GRR phosphate transport regulator FED53_03645 ENOG4105CJ3 phosphate transporter FED53_03650 ENOG41067TZ transcriptional regulator, MarR family FED53_03660 ENOG4108XJQ germination protein FED53_03665 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FED53_03670 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FED53_03675 ENOG4105M59 Phosphodiesterase, mj0936 family FED53_03685 ENOG4105C7K acetolactate synthase FED53_03690 ENOG4108ZP8 Acetolactate synthase small subunit FED53_03695 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FED53_03700 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FED53_03710 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FED53_03715 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FED53_03725 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FED53_03730 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FED53_03735 ENOG4108IUQ atp-dependent protease FED53_03745 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FED53_03755 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FED53_03765 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FED53_03775 ENOG4105D52 delta-aminolevulinic acid dehydratase FED53_03780 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FED53_03785 ENOG41068KH stage VI sporulation protein D FED53_03800 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FED53_03805 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FED53_03815 ENOG4108SJC Membrane FED53_03825 ENOG4105D7Q type ii secretion system FED53_03835 ENOG4106A3R peptidase FED53_03870 ENOG4105W5Q DNA repair protein (RadC FED53_03875 ENOG4105DFF Rod shape-determining protein mreb FED53_03880 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FED53_03885 ENOG4105YHC Rod shape-determining protein MreD FED53_03890 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FED53_03895 ENOG4107QMS site-determining protein FED53_03910 ENOG4105C03 ribonuclease FED53_03920 ENOG4105X36 (ribosomal) protein FED53_03925 ENOG4105K46 50S ribosomal protein l27 FED53_03940 ENOG41090I5 UPF0735 ACT domain-containing protein FED53_03945 ENOG4105CQC Prephenate dehydratase FED53_03960 ENOG4108IYU L-aspartate oxidase FED53_03965 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FED53_03970 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FED53_03975 ENOG4106678 morphogenetic protein associated with SpoVID FED53_03995 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FED53_04005 ENOG41061AI Protein of unknown function (DUF2905) FED53_04010 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FED53_04015 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FED53_04020 ENOG4105VIE preprotein translocase, subunit YajC FED53_04025 ENOG4105NAP FED53_04030 ENOG4108QG2 Membrane FED53_04035 ENOG4105CKP Polysaccharide Biosynthesis Protein FED53_04045 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FED53_04050 ENOG41076HS cation diffusion facilitator family transporter FED53_04055 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FED53_04060 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FED53_04065 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FED53_04075 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FED53_04085 ENOG4105CUT histidyl-tRNA synthetase FED53_04090 ENOG4105C9M aspartyl-trna synthetase FED53_04100 ENOG4105CUZ uba thif-type nad fad binding protein FED53_04105 ENOG4105D1H recombination factor protein RarA FED53_04115 ENOG4105C3J Cysteine desulfurase FED53_04120 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FED53_04130 ENOG4105C7H Helicase, RecD TraA family FED53_04135 ENOG41060CR FED53_04145 ENOG4105C02 permease FED53_04150 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FED53_04155 ENOG4105VBH UPF0297 protein FED53_04165 ENOG4105VPH UPF0473 protein FED53_04170 ENOG4105HHA aminodeoxychorismate lyase FED53_04175 ENOG4108VQJ O-methyltransferase FED53_04180 ENOG4105XYU peptidase (U32 family) FED53_04185 ENOG4105CFP Peptidase U32 FED53_04190 ENOG4105DBI uridine monophosphokinase FED53_04195 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FED53_04200 ENOG4107XRG penicillin-binding protein FED53_04215 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FED53_04220 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FED53_04230 ENOG4105C28 cystathionine FED53_04240 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FED53_04245 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FED53_04255 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FED53_04260 ENOG4105CQW ribosome biogenesis GTPase YqeH FED53_04265 ENOG4105E2X shikimate dehydrogenase FED53_04270 ENOG410812S Rna-binding protein FED53_04275 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FED53_04280 ENOG4108WF2 Metal Dependent Phosphohydrolase FED53_04290 ENOG4105DXX methyltransferase FED53_04300 ENOG4105KQC Competence protein FED53_04305 ENOG4108UK2 deaminase FED53_04310 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FED53_04320 ENOG4105TQK DNA polymerase iii, delta' subunit FED53_04325 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FED53_04340 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FED53_04345 ENOG4105CSA Coproporphyrinogen iii oxidase FED53_04355 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FED53_04365 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FED53_04370 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FED53_04375 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FED53_04380 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FED53_04390 ENOG4105KTH gatB Yqey FED53_04395 ENOG4105F7J membrane-bound serine protease FED53_04410 ENOG41068P3 sporulation protein YqfC FED53_04420 ENOG4105C9A Phoh family FED53_04425 ENOG4105CTJ Metal Dependent Phosphohydrolase FED53_04435 ENOG4107YR5 Diacylglycerol kinase FED53_04440 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FED53_04450 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FED53_04460 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FED53_04470 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FED53_04475 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FED53_04480 ENOG4105C1G acyl-Coa dehydrogenase FED53_04495 ENOG4105EGD dinuclear metal center protein, YbgI family FED53_04500 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FED53_04515 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FED53_04520 ENOG41069ZM Protein of unknown function (DUF2624) FED53_04525 ENOG4105FDK ABC transporter FED53_04530 ENOG4105FAV ABC, transporter FED53_04535 ENOG4105N80 Ferric uptake regulator, Fur family FED53_04540 ENOG4108U5J '-nucleotidase FED53_04545 ENOG41063Y9 FED53_04550 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FED53_04560 ENOG4107RCC Major Facilitator Superfamily FED53_04580 ENOG4105SXS Protein of unknown function (DUF456) FED53_04620 ENOG4107RF6 penicillin-binding protein FED53_04625 ENOG4105EXS phosphate abc transporter FED53_04630 ENOG4105C8U phosphate abc transporter FED53_04635 ENOG4105E2Z phosphate ABC transporter (Permease FED53_04640 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FED53_04645 ENOG4108UTW Plays a role in the regulation of phosphate uptake FED53_04675 ENOG410861F 50S ribosomal protein L33 FED53_04680 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FED53_04690 ENOG4107ZXI Rhomboid family FED53_04700 ENOG4105DKQ ROK family FED53_04705 ENOG4105E0M Sulfatase FED53_04720 ENOG4105C5X domain protein FED53_04745 ENOG4106855 Competence protein FED53_04785 ENOG4105C0D helicase FED53_04790 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FED53_04800 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FED53_04805 ENOG4105WZW rhodanese family FED53_04810 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FED53_04815 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FED53_04820 ENOG4105KST dependent repressor FED53_04835 ENOG4105CBJ Metal-dependent enzyme FED53_04845 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FED53_04850 ENOG4105DC7 peptidase M24 FED53_04855 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FED53_04865 ENOG4105CD2 stage iii sporulation protein aa FED53_04870 ENOG4105KR5 Stage iii sporulation protein FED53_04875 ENOG4108CQH stage III sporulation protein AC FED53_04880 ENOG4105KQ4 Stage iii sporulation protein ad FED53_04890 ENOG410644B Stage III sporulation protein af FED53_04910 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FED53_04915 ENOG4108ZSR alkaline shock protein FED53_04920 ENOG4105M7K Involved in the transcription termination process (By similarity) FED53_04930 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FED53_04945 ENOG4105DX0 Hemolysin A FED53_04955 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FED53_04960 ENOG4105S1Z Stage IV sporulation protein B FED53_04965 ENOG4107QQR Sporulation FED53_04980 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FED53_04990 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FED53_04995 ENOG4106CCJ Protein of unknown function (DUF2627) FED53_05000 ENOG4108JUB Transcriptional regulator FED53_05010 ENOG4107RDP Dehydrogenase FED53_05030 ENOG4105CPP Dehydrogenase, E1 component FED53_05035 ENOG4105C7S Dehydrogenase FED53_05045 ENOG4105D5P Methylmalonyl-coA mutase FED53_05055 ENOG4108Y6J UPF0403 protein FED53_05060 ENOG4108HW3 (ABC) transporter FED53_05065 ENOG4105E5Q amino acid AbC transporter FED53_05070 ENOG4105CDA abc transporter atp-binding protein FED53_05075 ENOG4108QEG Membrane FED53_05080 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FED53_05085 ENOG4108ZVT methylmalonyl-coA epimerase FED53_05090 ENOG4108HNZ carboxyl transferase FED53_05095 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FED53_05100 ENOG4105BZ8 glutamate synthase FED53_05105 ENOG4107SJI Dehydrogenase FED53_05130 ENOG4105G9B Transcriptional regulator FED53_05135 ENOG4105C26 Dehydrogenase FED53_05140 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FED53_05145 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FED53_05150 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FED53_05155 ENOG4105II7 pyrroline-5-carboxylate reductase FED53_05160 ENOG41069FQ Metallo-beta-lactamase superfamily FED53_05165 ENOG4108IXY short-chain dehydrogenase reductase FED53_05180 ENOG4106HZJ FED53_05185 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FED53_05190 ENOG4105CHU acetyl-coa acetyltransferase FED53_05195 ENOG4105D6N CoA-transferase, subunit a FED53_05200 ENOG4108IIH CoA-transferase subunit B FED53_05210 ENOG4105CPC Aldo Keto reductase FED53_05220 ENOG4108YZ4 nudix hydrolase FED53_05225 ENOG4105MZ9 stage II sporulation protein m FED53_05230 ENOG4105I3K Ferric uptake regulator, Fur family FED53_05245 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FED53_05265 ENOG4105DZ1 carboxypeptidase FED53_05270 ENOG41082AN stage II sporulation protein FED53_05275 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FED53_05280 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FED53_05295 ENOG41090VF Stage v sporulation protein ac FED53_05300 ENOG4105CZ3 stage V sporulation protein ad FED53_05310 ENOG4105G6R Stage v sporulation protein ae FED53_05320 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FED53_05325 ENOG4105PTM secreted protein FED53_05330 ENOG4107ZE5 PPIases accelerate the folding of proteins FED53_05355 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FED53_05360 ENOG4105DZ1 carboxypeptidase FED53_05365 ENOG4108JIC nucleoside recognition domain protein FED53_05375 ENOG4105FE9 pseudouridine synthase FED53_05380 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FED53_05385 ENOG4107TWT Cytochrome c biogenesis protein FED53_05390 ENOG4105CRE cytochrome C FED53_05395 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FED53_05400 ENOG4105BZU Histidine kinase FED53_05405 ENOG4105DR5 peptidase FED53_05410 ENOG4108JQ1 Dehydrogenase FED53_05415 ENOG4108SAX Membrane FED53_05430 ENOG4105C9U ATP-dependent DNA helicase RecQ FED53_05445 ENOG4107RGJ metallophosphoesterase FED53_05450 ENOG4108XDN Transcriptional regulator FED53_05455 ENOG4108S6Z Negative regulator of genetic competence FED53_05465 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FED53_05470 ENOG4107RB3 L-asparaginase FED53_05480 ENOG4105F0V Cell wall hydrolase FED53_05485 ENOG4105MSI germination protein ypeb FED53_05495 ENOG4105CAT Cytidine monophosphate kinase FED53_05500 ENOG4105E9Q Acyl-transferase FED53_05505 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FED53_05510 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FED53_05515 ENOG4105DJB Major Facilitator Superfamily FED53_05535 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FED53_05555 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FED53_05560 ENOG4105K70 DNA-binding protein FED53_05565 ENOG4105EUJ GTP cyclohydrolase i FED53_05570 ENOG4105WP2 Tryptophan RNA-binding attenuator protein FED53_05575 ENOG4105XXQ heptaprenyl diphosphate synthase component I FED53_05580 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FED53_05585 ENOG4105EAH synthase FED53_05590 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FED53_05595 ENOG4105BZU Histidine kinase FED53_05600 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FED53_05605 ENOG4105D49 3-dehydroquinate synthase FED53_05615 ENOG4108I0Q anthranilate phosphoribosyltransferase FED53_05620 ENOG4105DK0 Indole-3-glycerol phosphate synthase FED53_05625 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FED53_05630 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FED53_05635 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FED53_05640 ENOG4105CIH Imidazole acetol-phosphate transaminase FED53_05650 ENOG41068YB TPR repeat-containing protein FED53_05655 ENOG4108SXZ UPF0302 protein FED53_05665 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FED53_05670 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FED53_05675 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FED53_05720 ENOG4106H78 methyltransferase FED53_05725 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FED53_05730 ENOG4105H20 Sporulation integral membrane protein YlbJ FED53_05735 ENOG4105D78 K07001 NTE family protein FED53_05740 ENOG41063PX domain protein FED53_05745 ENOG4105CDE UPF0348 protein FED53_05750 ENOG4105KNH Nucleic acid-binding protein FED53_05755 ENOG41067VY 50S ribosomal protein L32 FED53_05760 ENOG4105E39 Enoyl-CoA hydratase FED53_05770 ENOG4108YG3 N-acetyltransferase FED53_05775 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FED53_05780 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FED53_05785 ENOG4107QX3 carboxylase FED53_05800 ENOG41074B2 UPF0747 protein FED53_05810 ENOG41068DC Essential cell division protein (By similarity) FED53_05815 ENOG4105CJN penicillin-binding protein FED53_05820 ENOG4105CJN penicillin-binding protein FED53_05825 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FED53_05830 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FED53_05835 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FED53_05840 ENOG4105CNI cell division protein FtsW FED53_05845 ENOG4105D4A Cell wall formation (By similarity) FED53_05850 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FED53_05855 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FED53_05860 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FED53_05865 ENOG4108AWX Sporulation factor SpoIIGA FED53_05870 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FED53_05880 ENOG4105WR5 sporulation protein, YlmC YmxH family FED53_05885 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FED53_05890 ENOG4105DFA alanine racemase domain protein FED53_05895 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FED53_05900 ENOG41067XK integral membrane protein FED53_05905 ENOG4105DBK s4 domain protein FED53_05925 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FED53_05930 ENOG4105C34 Pseudouridine synthase FED53_05935 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FED53_05950 ENOG4105CD3 dihydroorotase FED53_05970 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) FED53_05980 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FED53_05985 ENOG4105F23 Fibronectin-binding protein FED53_05995 ENOG4105DSJ YicC domain protein FED53_06000 ENOG4105KC4 UPF0296 protein FED53_06005 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FED53_06015 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FED53_06020 ENOG4105C25 Primosomal protein n' FED53_06025 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FED53_06030 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FED53_06035 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FED53_06040 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FED53_06045 ENOG4108ZF3 Phosphatase FED53_06050 ENOG4105D9P serine threonine protein kinase FED53_06055 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FED53_06060 ENOG4105DJV ribulose-phosphate 3-epimerase FED53_06065 ENOG4105FJ0 thiamine FED53_06075 ENOG4105VB9 50S ribosomal protein l28 FED53_06080 ENOG4108ZAA Alkaline-shock protein FED53_06085 ENOG4105DP4 dak2 domain fusion protein ylov FED53_06100 ENOG4105EJQ L-serine dehydratase FED53_06105 ENOG4105CB5 ATP-dependent DNA helicase recG FED53_06110 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) FED53_06115 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FED53_06120 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FED53_06125 ENOG4105CHR reductase FED53_06130 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FED53_06135 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FED53_06140 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FED53_06145 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FED53_06160 ENOG4105K5M 30s ribosomal protein S16 FED53_06165 ENOG4105VB6 UPF0109 protein FED53_06175 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FED53_06180 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FED53_06185 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FED53_06200 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FED53_06210 ENOG4105VM1 flagellar FED53_06220 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FED53_06225 ENOG4105C79 DNA protecting protein DprA FED53_06230 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FED53_06240 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FED53_06245 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FED53_06250 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FED53_06255 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) FED53_06260 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FED53_06265 ENOG4108ZC9 flagellar basal-body rod protein flgc FED53_06270 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FED53_06275 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FED53_06280 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FED53_06295 ENOG4106YF4 Flagellar biosynthesis chaperone FED53_06310 ENOG410822I Flagellar hook capping protein FED53_06315 ENOG4108JQA flagellar FED53_06320 ENOG41068WV flagellar FlbD family protein FED53_06330 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FED53_06335 ENOG4105DD5 Flagellar motor switch protein FED53_06340 ENOG4107YTP response regulator receiver protein FED53_06350 ENOG4105CN7 Flagellar biosynthetic protein FliP FED53_06355 ENOG4105VS8 Flagellar biosynthetic protein fliq FED53_06360 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FED53_06365 ENOG4105D00 flagellar biosynthetic protein flhB FED53_06370 ENOG4105D7B Flagellar biosynthesis protein flha FED53_06375 ENOG4105FZW flagellar biosynthesis regulator FlhF FED53_06385 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FED53_06390 ENOG4105CBS Chea signal transduction histidine kinase FED53_06395 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis FED53_06405 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) FED53_06410 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FED53_06420 ENOG4105CE9 30S ribosomal protein S2 FED53_06425 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FED53_06435 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FED53_06440 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FED53_06445 ENOG4105KNE Phosphatidate cytidylyltransferase FED53_06450 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FED53_06455 ENOG4105DZP Membrane-associated zinc metalloprotease FED53_06460 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FED53_06465 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FED53_06475 ENOG4105EKQ RNA-directed DNA polymerase FED53_06490 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FED53_06495 ENOG4105CHV Transcription elongation factor NusA FED53_06500 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FED53_06505 ENOG4105VHM ribosomal protein FED53_06510 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FED53_06515 ENOG4105W7A Protein of unknown function (DUF503) FED53_06530 ENOG4105DTN riboflavin biosynthesis protein ribF FED53_06535 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FED53_06540 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FED53_06550 ENOG4105C1V Peptidase, M16 FED53_06560 ENOG4105E35 Dipicolinate synthase subunit A FED53_06565 ENOG4108S0H Dipicolinic acid synthetase, b subunit FED53_06570 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FED53_06580 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FED53_06590 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FED53_06600 ENOG4105CNU cell division protein FtsK FED53_06605 ENOG4105FDP GntR family transcriptional regulator FED53_06610 ENOG4105DIH basic membrane FED53_06615 ENOG4108JQ9 ABC transporter FED53_06620 ENOG4105UIB (ABC) transporter FED53_06640 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FED53_06645 ENOG4105XZV Protein of unknown function (DUF3243) FED53_06660 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FED53_06665 ENOG4105CEV competence damage-inducible protein FED53_06680 ENOG4105D48 metallophosphoesterase FED53_06685 ENOG4105MCT stage V sporulation protein S FED53_06695 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FED53_06700 ENOG4105DQU oxidoreductase, subunit beta FED53_06705 ENOG4105CPQ Dehydrogenase FED53_06710 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FED53_06715 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FED53_06730 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FED53_06735 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FED53_06745 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FED53_06755 ENOG4106F1P AAA ATPase, central domain protein FED53_06760 ENOG4105EN6 Membrane FED53_06765 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FED53_06770 ENOG4105CXI aluminum resistance protein FED53_06775 ENOG4105KV4 Transcriptional regulator FED53_06780 ENOG4105C5F glutamine synthetase FED53_06785 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FED53_06790 ENOG410635T phage-like element pbsx protein FED53_07020 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FED53_07050 ENOG4105CNU cell division protein FtsK FED53_07080 ENOG4107R7I amino acid FED53_07085 ENOG4108U05 Transcriptional regulator FED53_07090 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FED53_07110 ENOG4107TVP HD domain protein FED53_07115 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FED53_07130 ENOG4105GEU Spore germination protein FED53_07145 ENOG4105CHH sulfate transporter FED53_07145 ENOG4105CHH sulfate transporter FED53_07180 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FED53_07190 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FED53_07200 ENOG4108SVB resolvase FED53_07205 ENOG4105VPS UPF0291 protein FED53_07220 ENOG4105VXM UPF0154 protein FED53_07225 ENOG4105BZ1 (ABC) transporter FED53_07230 ENOG4105BZ1 (ABC) transporter FED53_07240 ENOG4107QIV Cytochrome c biogenesis protein FED53_07245 ENOG4107YTP response regulator receiver protein FED53_07250 ENOG4108U5N UPF0316 protein FED53_07265 ENOG4108JPW Aminotransferase FED53_07275 ENOG4107QTZ amino acid FED53_07280 ENOG4105C26 Dehydrogenase FED53_07300 ENOG4105BZU Histidine kinase FED53_07315 ENOG4106N3A copper homeostasis protein cutc FED53_07325 ENOG4105DY8 decarboxylase FED53_07355 ENOG4105CMG Carbohydrate kinase FED53_07360 ENOG4105CIY formyltetrahydrofolate deformylase FED53_07365 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FED53_07370 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FED53_07375 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FED53_07385 ENOG4105C7B Threonine dehydratase FED53_07395 ENOG4108RCR degv family FED53_07400 ENOG4105BZU Histidine kinase FED53_07405 ENOG4108KF3 Electron transport protein SCO1 SenC FED53_07410 ENOG41090WU lipolytic protein G-D-S-L family FED53_07435 ENOG4105BZU Histidine kinase FED53_07470 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FED53_07485 ENOG4107S4Y M20 DapE family protein YgeY FED53_07495 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FED53_07510 ENOG4108TGC Acyltransferase FED53_07540 ENOG4105G0J serine threonine protein kinase FED53_07545 ENOG4108N23 SpoOM-related protein FED53_07550 ENOG410841Q phosphoesterase PA-phosphatase related protein FED53_07555 ENOG4106Z5R FED53_07560 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FED53_07565 ENOG4105CHH sulfate transporter FED53_07590 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FED53_07605 ENOG4105C5Y PTS System FED53_07610 ENOG4105D7K pfkb domain protein FED53_07620 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FED53_07635 ENOG4108IUW ABC transporter FED53_07645 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FED53_07695 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FED53_07700 ENOG4105K4H Nlp p60 protein FED53_07705 ENOG4105CTQ phosphohexokinase FED53_07710 ENOG4107YZX Universal stress protein FED53_07715 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FED53_07730 ENOG4105C37 (CBS) domain FED53_07735 ENOG4105K4I Scp-like extracellular FED53_07740 ENOG4105D64 Mechanosensitive ion channel FED53_07745 ENOG4108QY0 Membrane FED53_07750 ENOG4108NIW Leucine export protein LeuE FED53_07755 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FED53_07765 ENOG4105EA8 2-Nitropropane dioxygenase FED53_07770 ENOG4108HGU Histidine kinase FED53_07775 ENOG4105ETE Transcriptional regulator (LacI family FED53_07795 ENOG4105DRS transport system, permease FED53_07800 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FED53_07820 ENOG4105EHZ conserved protein UCP016719 FED53_07825 ENOG4105D17 glycoside hydrolase, family 3 domain protein FED53_07830 ENOG41067SE Tetr family transcriptional regulator FED53_07835 ENOG4105C0R drug resistance transporter emrb qaca subfamily FED53_07840 ENOG4105KNA -acetyltransferase FED53_07855 ENOG4108IJ8 ABC transporter FED53_07860 ENOG4105E90 ABC transporter FED53_07870 ENOG4108RCF TRANSCRIPTIONal FED53_07880 ENOG4105DC7 peptidase M24 FED53_07885 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) FED53_07905 ENOG4107TXC Transcriptional regulator FED53_07910 ENOG4108S4H thioesterase Superfamily protein FED53_07915 ENOG4105JFG SpoIID LytB domain protein FED53_07920 ENOG4105F3H Histidine kinase FED53_07930 ENOG4105C0H protease FED53_07945 ENOG4107ZYR domain protein FED53_07950 ENOG4105CZN Potassium uptake protein FED53_07955 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin FED53_07960 ENOG4106YBV Methyl-accepting chemotaxis FED53_07985 ENOG4107QQG Dehydrogenase FED53_07990 ENOG4105K64 Glycosyl transferase, family 2 FED53_08015 ENOG4108HKT sucrose-6-phosphate hydrolase FED53_08020 ENOG4108ZHJ Organic hydroperoxide resistance protein FED53_08035 ENOG4105I4A GCN5-related N-acetyltransferase FED53_08050 ENOG4105K7W phage-related replication protein FED53_08055 ENOG4105W1N transcriptional regulator FED53_08060 ENOG4105IIP Membrane FED53_08065 ENOG4108ZCF integral membrane protein FED53_08070 ENOG4105EXC Acyl-transferase FED53_08115 ENOG4105VPX protein, conserved in bacteria FED53_08120 ENOG410681U heavy metal transport detoxification protein FED53_08125 ENOG4105C59 p-type ATPase FED53_08130 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FED53_08140 ENOG4105DTQ mandelate racemase muconate lactonizing FED53_08175 ENOG4105VDT -acetyltransferase FED53_08180 ENOG4105C22 threonyL-tRNA synthetase FED53_08200 ENOG4105F1N DNA alkylation repair FED53_08205 ENOG4105FE9 pseudouridine synthase FED53_08220 ENOG4105EHG Permease protein FED53_08225 ENOG4105DQ5 transport system permease protein FED53_08235 ENOG4105E0A ABC, transporter FED53_08240 ENOG4105CAY ferredoxin--nadp reductase FED53_08245 ENOG4105C28 cystathionine FED53_08260 ENOG4105CFC Transporter FED53_08270 ENOG41082BM Transcriptional regulator, arsr family FED53_08280 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FED53_08285 ENOG4105C37 (CBS) domain FED53_08300 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FED53_08315 ENOG4105DJ2 Major Facilitator Superfamily FED53_08335 ENOG4105C2C drug resistance transporter, Bcr CflA FED53_08345 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FED53_08350 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FED53_08355 ENOG41080UX Methyltransferase FED53_08365 ENOG4105BZU Histidine kinase FED53_08370 ENOG4105BZU Histidine kinase FED53_08375 ENOG4108MJI response regulator FED53_08385 ENOG4105ETE Transcriptional regulator (LacI family FED53_08390 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FED53_08395 ENOG4108HKT sucrose-6-phosphate hydrolase FED53_08415 ENOG4107ZXU DSBA oxidoreductase FED53_08470 ENOG4105ETE Transcriptional regulator (LacI family FED53_08480 ENOG4105C0A alcohol dehydrogenase FED53_08545 ENOG4108W8B Beta-lactamase domain protein FED53_08555 ENOG4105GVJ transcriptional regulator FED53_08560 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FED53_08580 ENOG4105E1F short-chain dehydrogenase reductase FED53_08585 ENOG4107SCQ Iron-containing alcohol dehydrogenase FED53_08600 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FED53_08605 ENOG4105CPC Aldo Keto reductase FED53_08615 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FED53_08625 ENOG4105JXH GntR family transcriptional regulator FED53_08650 ENOG4105VEQ Cold shock protein FED53_08655 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FED53_08660 ENOG410814C multidrug resistance protein FED53_08685 ENOG4105KK4 UPF0060 membrane protein FED53_08690 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) FED53_08705 ENOG4108W0I acetyltransferase FED53_08715 ENOG4105D01 (LipO)protein FED53_08720 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FED53_08725 ENOG4108UMI ABC transporter, permease FED53_08730 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FED53_08760 ENOG4107ZQN disulfide bond FED53_08785 ENOG4105X5K response regulator receiver protein FED53_08835 ENOG41087NI Sulfite exporter TauE/SafE FED53_08855 ENOG4105WMR Protein CrcB homolog FED53_08870 ENOG4105XTG Pfam:DUF156 FED53_08880 ENOG4105E2S oxidase) subunit II FED53_08885 ENOG4105BZ9 Cytochrome C oxidase, subunit I FED53_08895 ENOG41060D1 Quinol oxidase FED53_08905 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FED53_08920 ENOG41068WN FED53_08925 ENOG4108KGH TRANSCRIPTIONal FED53_08945 ENOG4105VCH membrane FED53_08960 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FED53_08985 ENOG4105CMU LysR family (Transcriptional regulator FED53_08990 ENOG4105BZN citrate synthase FED53_08995 ENOG4105HMI Membrane FED53_09005 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FED53_09025 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FED53_09045 ENOG4105C8J )-transporter FED53_09050 ENOG4105KRN Transcriptional regulator, abrb family FED53_09055 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FED53_09065 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FED53_09090 ENOG4105YVS arsR family transcriptional regulator FED53_09110 ENOG4105C3F Signal peptidase i FED53_09115 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FED53_09160 ENOG4105C8J )-transporter FED53_09170 ENOG4105CH6 catalase FED53_09175 ENOG4105K4H Nlp p60 protein FED53_09185 ENOG4105G9B Transcriptional regulator FED53_09200 ENOG4105C5R Aminotransferase FED53_09205 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FED53_09210 ENOG4105CAH Chromate FED53_09215 ENOG4105FGV Chromate FED53_09220 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FED53_09260 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FED53_09270 ENOG4105VUN Transcriptional regulator FED53_09275 ENOG4105CAH Chromate FED53_09285 ENOG4105C37 (CBS) domain FED53_09290 ENOG4108XI2 Domain of unknown function (DUF1963) FED53_09305 ENOG4108RMU ferritin dps family protein FED53_09340 ENOG4105BZ1 (ABC) transporter FED53_09355 ENOG4105BZU Histidine kinase FED53_09360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FED53_09365 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) FED53_09375 ENOG4105BZ4 penicillin-binding protein FED53_09380 ENOG4105FBA Phospholipase Carboxylesterase FED53_09400 ENOG4108DBC nitroreductase FED53_09405 ENOG41069ER domain protein FED53_09410 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein FED53_09415 ENOG4105C32 Amino acid ABC transporter (Permease) FED53_09425 ENOG4105D5T phosphonate abc transporter FED53_09430 ENOG4108IV0 ABC, transporter FED53_09435 ENOG4108YZ9 Urea amidohydrolase subunit gamma FED53_09440 ENOG4105KI2 Urea amidohydrolase subunit beta FED53_09495 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FED53_09500 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FED53_09505 ENOG4105KVH Transcriptional regulator FED53_09520 ENOG4108IA2 Sodium pantothenate symporter FED53_09525 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FED53_09530 ENOG4105EHG Permease protein FED53_09535 ENOG4108IPW abc transporter atp-binding protein FED53_09545 ENOG4105FDT acyl-CoA dehydrogenase FED53_09560 ENOG4107QJZ Glycosyl transferase, family 2 FED53_09565 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FED53_09570 ENOG4105C5E polysaccharide biosynthesis protein FED53_09585 ENOG4107FKK extracellular solute-binding protein family 1 FED53_09595 ENOG4105EG2 ABC transporter, permease FED53_09610 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) FED53_09615 ENOG4105K64 Glycosyl transferase, family 2 FED53_09630 ENOG4105RHY Pfam:UPF0157 FED53_09670 ENOG4105DHF Membrane FED53_09680 ENOG4108X3M OsmC Ohr family protein FED53_09685 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FED53_09690 ENOG4105C7S Dehydrogenase FED53_09710 ENOG4108Z12 YiaAB two helix domain-containing protein FED53_09740 ENOG4107RHR regulatoR FED53_09750 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FED53_09755 ENOG4105KG3 cytidine deaminase FED53_09760 ENOG4105D9N nucleoside FED53_09765 ENOG4105IW1 AmiS UreI transporter FED53_09820 ENOG4107Y9E nuclease FED53_09825 ENOG4105BZU Histidine kinase FED53_09830 ENOG4108NEV two component transcriptional regulator, LytTR family FED53_09850 ENOG4105CIB oxidoreductase Domain protein FED53_09855 ENOG4107QP6 Xylose isomerase domain protein TIM barrel FED53_09860 ENOG4105IE8 Alpha-ketoglutarate permease FED53_09870 ENOG4108VA3 3-hexulose-6-phosphate synthase FED53_09885 ENOG4105CV8 reductase FED53_09900 ENOG4105XXY Thioredoxin FED53_09920 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FED53_09925 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FED53_09955 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FED53_09965 ENOG4108RZA ABC transporter FED53_09970 ENOG4108JQ7 (ABC) transporter FED53_09980 ENOG4108JCI Transcriptional regulator FED53_09995 ENOG4105N14 lysine exporter protein LysE YggA FED53_10010 ENOG4107P26 FED53_10035 ENOG4107Y03 Nitroreductase FED53_10040 ENOG4105SX7 Transporter FED53_10045 ENOG4107RRN ABC transporter substrate-binding protein FED53_10070 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FED53_10075 ENOG4105I1K ABC transporter FED53_10095 ENOG4105CMG Carbohydrate kinase FED53_10100 ENOG4107QNK )-transporter FED53_10110 ENOG4105CUC YeeE YedE family protein FED53_10175 ENOG4105FDP GntR family transcriptional regulator FED53_10200 ENOG4105C6T cysteine synthase FED53_10205 ENOG4105EWC Purine nucleoside phosphorylase FED53_10210 ENOG4105D94 Major Facilitator Superfamily FED53_10215 ENOG4107RSM transcriptional regulator FED53_10230 ENOG4108UZ3 Transporter FED53_10235 ENOG4108MCI Transcriptional regulator, ARAC family FED53_10280 ENOG4106FGC FED53_10340 ENOG4105C98 muts2 protein FED53_10390 ENOG4108MK9 spermidine N(1)-acetyltransferase FED53_10430 ENOG4108X4Q Hydrolase FED53_10460 ENOG4108YM7 Gcn5-related n-acetyltransferase FED53_10480 ENOG4105CV8 reductase FED53_10490 ENOG4105U6C Alpha beta hydrolase fold protein FED53_10495 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FED53_10510 ENOG4105KNA -acetyltransferase FED53_10560 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FED53_10590 ENOG4105XTG Pfam:DUF156 FED53_10595 ENOG4105VFE sira family FED53_10600 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FED53_10605 ENOG41085GJ domain protein FED53_10610 ENOG4105VFE sira family FED53_10615 ENOG4107TPS domain protein FED53_10620 ENOG4105VFE sira family FED53_10625 ENOG41087NI Sulfite exporter TauE/SafE FED53_10635 ENOG4105CHR reductase FED53_10640 ENOG4108RZE Tetr family transcriptional regulator FED53_10645 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FED53_10655 ENOG4105C1G acyl-Coa dehydrogenase FED53_10660 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FED53_10690 ENOG4105K8R UPF0145 protein FED53_10710 ENOG41069ER domain protein FED53_10720 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FED53_10730 ENOG4105CS2 ec 3.2.1.21 FED53_10765 ENOG4105DWT malate dehydrogenase (quinone) FED53_10780 ENOG4105VEQ Cold shock protein FED53_10805 ENOG4108428 Inherit from COG: -acetyltransferase FED53_10810 ENOG4107R37 Glutamate dehydrogenase FED53_10815 ENOG4105C5Q Transcriptional regulator FED53_10825 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FED53_10915 ENOG4105KNA -acetyltransferase FED53_10925 ENOG4105EE0 oxidoreductase FED53_10930 ENOG41080HJ 6-phospho 3-hexuloisomerase FED53_10935 ENOG4108VA3 3-hexulose-6-phosphate synthase FED53_10940 ENOG4105KVH Transcriptional regulator FED53_10945 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FED53_10965 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FED53_10995 ENOG4105EEM helicase FED53_11000 ENOG4108PSK reductase FED53_11070 ENOG4105JD4 ATPase yjob FED53_11085 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FED53_11095 ENOG4107ZQV short-chain dehydrogenase reductase FED53_11100 ENOG410751J FED53_11120 ENOG4106A3M Cytochrome p-450 FED53_11125 ENOG4105JSC dimethylmenaquinone methyltransferase FED53_11135 ENOG4107S1Q Phosphatase FED53_11160 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FED53_11165 ENOG41073R8 VanW family FED53_11170 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) FED53_11185 ENOG4105P8F nudix hydrolase FED53_11210 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FED53_11225 ENOG4105EXQ uroporphyrinogen iii synthase hem4 FED53_11230 ENOG4107258 Transcriptional regulator FED53_11235 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FED53_11250 ENOG4105P4J Allophanate hydrolase, subunit 1 FED53_11255 ENOG4105CFM UPF0317 protein FED53_11260 ENOG4105C5A transporter FED53_11265 ENOG4105E7W lamb ycsf family protein FED53_11270 ENOG4105K4H Nlp p60 protein FED53_11280 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) FED53_11290 ENOG4105WH1 Two component transcriptional regulator luxr family FED53_11295 ENOG4105BZU Histidine kinase FED53_11310 ENOG4105C01 Dihydroxy-acid dehydratase FED53_11315 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FED53_11330 ENOG4105CM2 brancheD-chain amino acid aminotransferase FED53_11350 ENOG4105VT2 5-hydroxyisourate hydrolase FED53_11355 ENOG4105WCN acetyltransferase FED53_11365 ENOG4105U0R haloacid dehalogenase-like hydrolase FED53_11380 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FED53_11400 ENOG4108Z7F N-acetyltransferase FED53_11420 ENOG4107S9D Alpha beta hydrolase FED53_11430 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FED53_11435 ENOG4105K4P CoA-binding domain protein FED53_11440 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FED53_11445 ENOG4105W8X HesB YadR YfhF-family protein FED53_11460 ENOG41067CD Small, acid-soluble spore protein Tlp FED53_11465 ENOG41075ZD Small, acid-soluble spore protein N FED53_11475 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FED53_11480 ENOG4108I0Z Aconitate hydratase FED53_11485 ENOG410746C Acid-soluble spore protein O FED53_11495 ENOG4107DZX Small, acid-soluble spore protein P FED53_11505 ENOG4105FDF Could be involved in DNA repair (By similarity) FED53_11540 ENOG4105F27 Major Facilitator FED53_11545 ENOG4107U9T Pfam:Ribonuclease_BN FED53_11555 ENOG4105DXB Major Facilitator superfamily FED53_11560 ENOG4107SWG transcriptional regulator MERR family FED53_11565 ENOG4105CHH sulfate transporter FED53_11570 ENOG4108HYG acetyltransferase FED53_11575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FED53_11585 ENOG4105VRR gCN5-related N-acetyltransferase FED53_11605 ENOG4108ZRV stage ii sporulation protein p FED53_11610 ENOG4105BZU Histidine kinase FED53_11615 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FED53_11620 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FED53_11630 ENOG4105BZU Histidine kinase FED53_11650 ENOG4105DZC cytosine deaminase FED53_11660 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FED53_11680 ENOG4105DEN Luciferase family FED53_11700 ENOG4105CPK Glycosyl transferase (Group 1 FED53_11715 ENOG4105CGN Glycosyl transferase (Group 1 FED53_11720 ENOG4105C1B dTDP-glucose 4-6-dehydratase FED53_11745 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FED53_11755 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FED53_11760 ENOG4105DEN Luciferase family FED53_11770 ENOG4107T5V SNARE associated Golgi FED53_11775 ENOG4105UQX Mate efflux family protein FED53_11780 ENOG4105DPN Oligoendopeptidase f FED53_11785 ENOG4105CGK Exodeoxyribonuclease III FED53_11790 ENOG4105CGH 5'-nucleotidase FED53_11805 ENOG4107U9T Pfam:Ribonuclease_BN FED53_11810 ENOG4107TUM Amidinotransferase FED53_11815 ENOG4107R13 MMPL domain protein FED53_11840 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FED53_11845 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FED53_11850 ENOG4105II7 pyrroline-5-carboxylate reductase FED53_11880 ENOG41069ER domain protein FED53_11895 ENOG4105K56 Transcriptional regulator FED53_11900 ENOG4108ZHJ Organic hydroperoxide resistance protein FED53_11925 ENOG4105DVE abc transporter atp-binding protein FED53_11930 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FED53_11935 ENOG4105DUM transcriptional regulator, lysR family FED53_11945 ENOG4105KWG Pfam:DUF1696 FED53_11955 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FED53_11960 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FED53_11965 ENOG4105C9U ATP-dependent DNA helicase RecQ FED53_11980 ENOG4105MEW serine threonine protein phosphatase FED53_11990 ENOG4105C9U ATP-dependent DNA helicase RecQ FED53_12030 ENOG4105F6S Spore photoproduct lyase FED53_12050 ENOG4105DFD Na H antiporter FED53_12060 ENOG4105CJ1 ABC, transporter FED53_12065 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ FED53_12070 ENOG4105C5H ABC transporter FED53_12075 ENOG4105CSR polyphosphate kinase 2 FED53_12080 ENOG4105DEN Luciferase family FED53_12085 ENOG4105D29 Helix-turn-helix type 11 domain protein FED53_12090 ENOG4105NAE bifunctional deaminase-reductase domain protein FED53_12100 ENOG4105EU0 Major facilitator Superfamily FED53_12105 ENOG4105DTD Dehydrogenase FED53_12115 ENOG4105CQB FAD linked oxidase domain protein FED53_12120 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FED53_12130 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FED53_12135 ENOG4105DAP Nicotinate phosphoribosyltransferase FED53_12145 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FED53_12155 ENOG4105BZ1 (ABC) transporter FED53_12195 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FED53_12210 ENOG4108IMY Transcriptional regulator FED53_12215 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FED53_12220 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family FED53_12225 ENOG4105D3Q Sugar transferase FED53_12235 ENOG4105CMR udp-glucose 4-epimerase FED53_12240 ENOG41068W6 Capsular polysaccharide biosynthesis protein FED53_12245 ENOG4108SHN Glycosyl transferase, family 2 FED53_12250 ENOG4108KMV Glycosyl transferase (Group 1 FED53_12255 ENOG4108PQP glycosyl transferase group 1 FED53_12265 ENOG4107YJ4 chain length determinant protein FED53_12270 ENOG4105HTX biosynthesis protein FED53_12295 ENOG41073R8 VanW family FED53_12300 ENOG4107VFR oxidoreductase FED53_12325 ENOG4105EWU Squalene--hopene cyclase FED53_12330 ENOG4105DKW ABC transporter FED53_12340 ENOG41075H3 AraC family transcriptional regulator FED53_12355 ENOG4107T89 von Willebrand factor, type A FED53_12360 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FED53_12370 ENOG4108AEY RNA polymerase sigma factor FED53_12375 ENOG4105J37 FED53_12390 ENOG410606W general stress protein FED53_12395 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FED53_12400 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FED53_12415 ENOG4108VX5 3-methyladenine DNA glycosylase FED53_12425 ENOG4105CK5 oxidoreductase FED53_12430 ENOG4105CK5 oxidoreductase FED53_12440 ENOG4105ETE Transcriptional regulator (LacI family FED53_12445 ENOG4105F0V Cell wall hydrolase FED53_12450 ENOG4105C8J )-transporter FED53_12470 ENOG4105ETU transcriptional activator (TenA FED53_12475 ENOG4105C26 Dehydrogenase FED53_12510 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FED53_12520 ENOG4105CFH Aspartokinase FED53_12525 ENOG4105DM4 PTS System FED53_12530 ENOG4105DE4 1-phosphofructokinase FED53_12535 ENOG4105E98 transcriptional regulator DeoR family FED53_12545 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FED53_12565 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FED53_12590 ENOG4108QMY dioxygenase FED53_12595 ENOG4105CHU acetyl-coa acetyltransferase FED53_12605 ENOG4105DTQ mandelate racemase muconate lactonizing FED53_12610 ENOG4108IIH CoA-transferase subunit B FED53_12615 ENOG4107QP7 CoA-transferase subunit A FED53_12625 ENOG4106IPI cyclase, family FED53_12635 ENOG4108QMY dioxygenase FED53_12640 ENOG4105U1N riboflavin FED53_12690 ENOG4105H67 Protein of unknown function (DUF421) FED53_12695 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FED53_12705 ENOG4108QY0 Membrane FED53_12720 ENOG4105CZ3 stage V sporulation protein ad FED53_12725 ENOG41090VF Stage v sporulation protein ac FED53_12750 ENOG4105BZU Histidine kinase FED53_12770 ENOG4105CKK Glycosyl transferase, family 2 FED53_12775 ENOG4105EDW glycosyl transferase, family 39 FED53_12780 ENOG4105WEF catalase FED53_12800 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FED53_12805 ENOG4105C02 permease FED53_12810 ENOG4105C26 Dehydrogenase FED53_12830 ENOG4105BZ8 glutamate synthase FED53_12835 ENOG4105CBC glutamate synthase FED53_12840 ENOG4105C5Q Transcriptional regulator FED53_12850 ENOG4108R1P FED53_12865 ENOG4105VUC UPF0237 protein FED53_12870 ENOG4105CAG UPF0210 protein FED53_12885 ENOG410905X membrane-flanked domain protein FED53_12895 ENOG4108IJ0 Aspartate ammonia-lyase FED53_12900 ENOG4108URH decarboxylase FED53_12905 ENOG4108QY0 Membrane FED53_12915 ENOG410667J hydrolase FED53_12920 ENOG4105C6K Malic enzyme FED53_12930 ENOG4105DUX Transporter FED53_12935 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) FED53_12940 ENOG4105BZU Histidine kinase FED53_12950 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FED53_12960 ENOG4105DFD Na H antiporter FED53_12965 ENOG4108NA0 Uncharacterized conserved protein (COG2071) FED53_12975 ENOG4105ER2 Ompa motb domain protein FED53_12980 ENOG4105E14 MotA TolQ exbB proton channel FED53_12990 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FED53_12995 ENOG4105C26 Dehydrogenase FED53_13000 ENOG4107R6U sodium dicarboxylate symporter FED53_13010 ENOG4105IIU Aminopeptidase FED53_13020 ENOG4108ZJ4 polysaccharide deacetylase FED53_13035 ENOG4105CDW Resistance protein FED53_13055 ENOG4105CHR reductase FED53_13060 ENOG4107QMU Mate efflux family protein FED53_13065 ENOG4105KRN Transcriptional regulator, abrb family FED53_13080 ENOG4105DWD nucleoside recognition domain protein FED53_13095 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FED53_13100 ENOG4105II7 pyrroline-5-carboxylate reductase FED53_13105 ENOG4108TN2 lmbE family FED53_13130 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FED53_13135 ENOG4107QRP cobalamin biosynthesis protein CobW FED53_13145 ENOG4105FR1 rard protein FED53_13150 ENOG4108WBT adenosyltransferase FED53_13160 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FED53_13165 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FED53_13175 ENOG4105CIH Imidazole acetol-phosphate transaminase FED53_13180 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FED53_13190 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FED53_13200 ENOG4105SZ6 Thioredoxin FED53_13215 ENOG4107YX5 Pfam:DUF548 FED53_13240 ENOG4105C5H ABC transporter FED53_13250 ENOG4108V06 Glutathione peroxidase FED53_13265 ENOG4105CVG Homoserine O-transsuccinylase FED53_13280 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FED53_13295 ENOG4105E2R ROK family FED53_13300 ENOG4107FKK extracellular solute-binding protein family 1 FED53_13315 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FED53_13320 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FED53_13325 ENOG4105CZM Major Facilitator FED53_13335 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FED53_13345 ENOG4105C0R drug resistance transporter emrb qaca subfamily FED53_13370 ENOG4105C9U ATP-dependent DNA helicase RecQ FED53_13400 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FED53_13450 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FED53_13455 ENOG410667J hydrolase FED53_13470 ENOG4107R5R arsenical pump membrane protein FED53_13475 ENOG41082YX Transcriptional regulator, arsr family FED53_13485 ENOG41085FC arsR family transcriptional regulator FED53_13490 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FED53_13525 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FED53_13530 ENOG4105FQP Beta-lactamase FED53_13535 ENOG4105CS1 NAD(P)H quinone oxidoreductase FED53_13540 ENOG4107XWI flavin reductase domain protein, FMN-binding FED53_13555 ENOG41090UD (LipO)protein FED53_13560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FED53_13565 ENOG4105BZU Histidine kinase FED53_13585 ENOG4108S01 response regulator FED53_13590 ENOG4108ZGX Histidine kinase FED53_13595 ENOG4105ECK Fatty Acid Desaturase FED53_13605 ENOG4107RU2 Histidinol phosphate phosphatase, HisJ family FED53_13610 ENOG4108PJD permease FED53_13630 ENOG4108JQ7 (ABC) transporter FED53_13635 ENOG4107SN7 NLP P60 protein FED53_13640 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FED53_13650 ENOG4105C3U ABC transporter FED53_13655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FED53_13660 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FED53_13665 ENOG4108ME1 Peptidase M55 D-aminopeptidase FED53_13720 ENOG41081VK Ribonuclease FED53_13750 ENOG410890F Dynamin family FED53_13760 ENOG41065KQ synthase FED53_13770 ENOG4105C2W permease FED53_13775 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FED53_13780 ENOG4105CTD carboxy-peptidase FED53_13785 ENOG4105DVT helicase FED53_13800 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FED53_13810 ENOG4105WH1 Two component transcriptional regulator luxr family FED53_13815 ENOG4105ENE Histidine kinase FED53_13840 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FED53_13845 ENOG4106F55 Protein of unknown function (DUF1273) FED53_13855 ENOG4107X2U Inherit from COG: Exonuclease-like protein FED53_13860 ENOG4108I5C dEAD DEAH box helicase FED53_13870 ENOG4105C7Z Conserved Protein FED53_13890 ENOG4108IPW abc transporter atp-binding protein FED53_13895 ENOG4105CM4 permease protein FED53_13900 ENOG4105DHS permease protein FED53_13935 ENOG4105VEQ Cold shock protein FED53_13945 ENOG4105CK7 Sodium proline symporter FED53_13960 ENOG4105C28 cystathionine FED53_13965 ENOG4105C28 cystathionine FED53_14005 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FED53_14010 ENOG4105BZ4 penicillin-binding protein FED53_14020 ENOG4105CSM endonuclease III FED53_14030 ENOG4105C5S asparaginyl-tRNA synthetase FED53_14035 ENOG4105CHM Aminotransferase FED53_14045 ENOG4105YAC FED53_14055 ENOG4105DVT helicase FED53_14060 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FED53_14065 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FED53_14070 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FED53_14080 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FED53_14085 ENOG4105CPK Glycosyl transferase (Group 1 FED53_14090 ENOG4105FJR Lmbe family FED53_14095 ENOG4108Z5K methylglyoxal synthase FED53_14100 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FED53_14105 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FED53_14110 ENOG4108JYZ YitT family FED53_14125 ENOG4106UY4 Inherit from COG: Scp-like extracellular FED53_14130 ENOG41080XQ Signal transduction protein with cbs domains FED53_14165 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FED53_14170 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FED53_14175 ENOG4105CNI cell division protein FtsW FED53_14190 ENOG4108IAB Phoh family FED53_14215 ENOG4105QA2 FED53_14220 ENOG4105CI3 gtp-binding protein typa FED53_14230 ENOG4105ECY inositol monophosphatase FED53_14245 ENOG4105WBI UPF0223 protein FED53_14250 ENOG4105CXN decarboxylase FED53_14265 ENOG4105C94 Transporter FED53_14275 ENOG4107QN2 dihydrolipoyl dehydrogenase FED53_14280 ENOG4105C7S Dehydrogenase FED53_14285 ENOG4105CPP Dehydrogenase, E1 component FED53_14305 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FED53_14310 ENOG4108X4Q Hydrolase FED53_14315 ENOG4106148 UPF0356 protein FED53_14320 ENOG4105CN5 Metallo-Beta-Lactamase FED53_14335 ENOG4105CJ1 ABC, transporter FED53_14340 ENOG4105WH1 Two component transcriptional regulator luxr family FED53_14345 ENOG4105BZU Histidine kinase FED53_14350 ENOG4107ZYR domain protein FED53_14360 ENOG4105D3R alkyl hydroperoxide reductase FED53_14365 ENOG4105D8X mechanosensitive ion channel FED53_14370 ENOG4105CH2 amidohydrolase FED53_14375 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FED53_14385 ENOG4107IN1 Protein of unknown function (DUF1797) FED53_14400 ENOG4105EPM Diguanylate phosphodiesterase FED53_14405 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FED53_14420 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FED53_14425 ENOG4107R33 ppx gppa phosphatase FED53_14430 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein FED53_14435 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FED53_14445 ENOG4105UIN FED53_14450 ENOG4107R88 Chemotaxis protein (CheV) FED53_14465 ENOG4105CHM Aminotransferase FED53_14470 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FED53_14480 ENOG4105CHR reductase FED53_14490 ENOG4105CMU LysR family (Transcriptional regulator FED53_14495 ENOG4105KVH Transcriptional regulator FED53_14500 ENOG4108VA3 3-hexulose-6-phosphate synthase FED53_14505 ENOG41080HJ 6-phospho 3-hexuloisomerase FED53_14510 ENOG4105VAW lrga family FED53_14515 ENOG41067MG lrgb family FED53_14520 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FED53_14525 ENOG4105KRI phosphocarrier protein (HPr FED53_14535 ENOG4105CID antiterminator FED53_14545 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FED53_14550 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FED53_14555 ENOG4108R6K riboflavin synthase, subunit alpha FED53_14560 ENOG4108K88 Membrane FED53_14565 ENOG4107QM2 Aldo Keto reductase FED53_14605 ENOG4105CRW Short chain fatty acid transporter FED53_14620 ENOG4105F0V Cell wall hydrolase FED53_14635 ENOG4107UFZ Cyclic nucleotide-binding protein FED53_14645 ENOG4105K4T epimerase FED53_14650 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FED53_14655 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FED53_14660 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase FED53_14665 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FED53_14685 ENOG4105E1K spore germination protein FED53_14700 ENOG4105DFD Na H antiporter FED53_14720 ENOG41090MY MarR family Transcriptional regulator FED53_14745 ENOG4105CNN ABC, transporter FED53_14750 ENOG4105C2J ABC transporter FED53_14760 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FED53_14765 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FED53_14770 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) FED53_14775 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FED53_14785 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FED53_14790 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FED53_14795 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FED53_14805 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FED53_14810 ENOG4105BZU Histidine kinase FED53_14815 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FED53_14820 ENOG4105DAP Nicotinate phosphoribosyltransferase FED53_14825 ENOG4107G43 radical SAM domain protein FED53_14840 ENOG4105CHR reductase FED53_14860 ENOG410681C small acid-soluble spore protein FED53_14865 ENOG4107TS3 membrane protein, TerC FED53_14870 ENOG4105DY9 regulatoR FED53_14875 ENOG4105G6Z alkaline phosphatase FED53_14890 ENOG4108B31 Spore germination protein FED53_14895 ENOG4105E0X reductase FED53_14900 ENOG4105C0R drug resistance transporter emrb qaca subfamily FED53_14920 ENOG4105C7N Xanthine uracil vitamin C permease FED53_14925 ENOG4105DP8 Major facilitator superfamily MFS_1 FED53_14955 ENOG4105C3F Signal peptidase i FED53_14960 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FED53_14965 ENOG4105C37 (CBS) domain FED53_14975 ENOG4105CGH 5'-nucleotidase FED53_14980 ENOG4108JJ8 (ABC) transporter FED53_14985 ENOG4108JJ9 ABC, transporter FED53_15010 ENOG4105CJ1 ABC, transporter FED53_15035 ENOG4105CI1 PTS System FED53_15040 ENOG4105CE4 GlcNAc 6-P deacetylase FED53_15045 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FED53_15050 ENOG4105FDP GntR family transcriptional regulator FED53_15085 ENOG4105TRI Hydrolase FED53_15095 ENOG4108FUT Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FED53_15110 ENOG410751J FED53_15135 ENOG4105DWD nucleoside recognition domain protein FED53_15140 ENOG4105DTQ mandelate racemase muconate lactonizing FED53_15150 ENOG4106KNT transcriptional regulator FED53_15175 ENOG4108ZCF integral membrane protein FED53_15255 ENOG41067V3 Antibiotic biosynthesis monooxygenase FED53_15260 ENOG4107S8A protein TIM barrel FED53_15265 ENOG4105CPQ Dehydrogenase FED53_15270 ENOG4107S8A protein TIM barrel FED53_15280 ENOG4105WZ4 isomerase FED53_15285 ENOG4105CPQ Dehydrogenase FED53_15290 ENOG4107QP6 Xylose isomerase domain protein TIM barrel FED53_15300 ENOG4105CNN ABC, transporter FED53_15305 ENOG4105C2J ABC transporter FED53_15315 ENOG4105ETE Transcriptional regulator (LacI family FED53_15325 ENOG4108HRK Histidine kinase FED53_15330 ENOG4105EQD regulatoR FED53_15350 ENOG4106ANW SMI1_KNR4 FED53_15355 ENOG4106BHF FED53_15560 ENOG4108Z40 Transcriptional regulator FED53_15565 ENOG4105ECR NmrA family FED53_15575 ENOG4105PGS Spore coat protein FED53_15580 ENOG4105E2A Dehydrogenase FED53_15600 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FED53_15625 ENOG4108KGH TRANSCRIPTIONal FED53_15630 ENOG4107YJ4 chain length determinant protein FED53_15635 ENOG4105HTX biosynthesis protein FED53_15645 ENOG4107QRS glycosyltransferase group 2 family protein FED53_15655 ENOG4107T8Q Glycosyl transferase (Group 1 FED53_15660 ENOG4105D3Q Sugar transferase FED53_15670 ENOG4105CPF Cell wall formation (By similarity) FED53_15675 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FED53_15685 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FED53_15690 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FED53_15715 ENOG4105CMR udp-glucose 4-epimerase FED53_15745 ENOG4108IG5 Transcriptional regulator FED53_15755 ENOG4105C8Q Methyl-accepting chemotaxis FED53_15760 ENOG4105K4H Nlp p60 protein FED53_15775 ENOG4105BZU Histidine kinase FED53_15780 ENOG4105D17 glycoside hydrolase, family 3 domain protein FED53_15785 ENOG4105T65 Membrane-associated protein FED53_15795 ENOG4105T65 Membrane-associated protein FED53_15815 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FED53_15840 ENOG4105BZU Histidine kinase FED53_15855 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FED53_15860 ENOG4105BZU Histidine kinase FED53_15870 ENOG4105DVE abc transporter atp-binding protein FED53_15875 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FED53_15890 ENOG4105DH8 myo-inositol catabolism FED53_15915 ENOG4105CK5 oxidoreductase FED53_15920 ENOG4105IE8 Alpha-ketoglutarate permease FED53_15925 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FED53_15930 ENOG4105ETE Transcriptional regulator (LacI family FED53_15935 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FED53_15940 ENOG4105CNN ABC, transporter FED53_15945 ENOG4105C2J ABC transporter FED53_15970 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FED53_15990 ENOG4105C3M thioredoxin reductase FED53_16005 ENOG4105E66 phosphoriboisomerase A FED53_16010 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FED53_16020 ENOG4105C02 permease FED53_16075 ENOG4105KPY Small multidrug resistance protein FED53_16080 ENOG4105KPY Small multidrug resistance protein FED53_16085 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FED53_16110 ENOG4105EE0 oxidoreductase FED53_16130 ENOG4105VEQ Cold shock protein FED53_16135 ENOG4105DZC cytosine deaminase FED53_16140 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase FED53_16155 ENOG4108UT2 hemolysin iii FED53_16165 ENOG4108PJD permease FED53_16185 ENOG4105P4J Allophanate hydrolase, subunit 1 FED53_16190 ENOG4107414 GntR family transcriptional regulator FED53_16195 ENOG4105CG3 alpha amylase, catalytic region FED53_16200 ENOG4105C5Y PTS System FED53_16205 ENOG4108IPJ Membrane FED53_16215 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FED53_16220 ENOG4105C7N Xanthine uracil vitamin C permease FED53_16225 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FED53_16245 ENOG4108JPW Aminotransferase FED53_16255 ENOG4105CVJ phosphoglycerate mutase FED53_16280 ENOG4105BZU Histidine kinase FED53_16310 ENOG41069ER domain protein FED53_16315 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FED53_16320 ENOG4105CNN ABC, transporter FED53_16325 ENOG4105C2J ABC transporter FED53_16330 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FED53_16335 ENOG4108RVA ribokinase FED53_16340 ENOG4105ETE Transcriptional regulator (LacI family FED53_16350 ENOG4107258 Transcriptional regulator FED53_16365 ENOG4105MI2 FED53_16390 ENOG4105KVH Transcriptional regulator FED53_16395 ENOG4105ECB domain protein FED53_16405 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FED53_16415 ENOG4105ETU transcriptional activator (TenA FED53_16425 ENOG4107YBY Hydrolase FED53_16435 ENOG41089UC methyltransferase, type 11 FED53_16440 ENOG4108KK1 membrane protein AbrB duplication FED53_16445 ENOG4108KAM Transcriptional regulator FED53_16455 ENOG4108MRH transcriptional regulatory protein FED53_16465 ENOG4105D4T Citrate transporter FED53_16480 ENOG4108MRH transcriptional regulatory protein FED53_16485 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FED53_16490 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FED53_16495 ENOG4107QJT sodium dicarboxylate symporter FED53_16510 ENOG4105F0V Cell wall hydrolase FED53_16525 ENOG4107RBB ABC transporter, permease FED53_16530 ENOG4105C19 ABC transporter FED53_16535 ENOG4107X8C Efflux transporter RND family MFP subunit FED53_16550 ENOG4108S4H thioesterase Superfamily protein FED53_16560 ENOG4105Q95 Cupin 2, conserved barrel domain protein FED53_16565 ENOG4105F27 Major Facilitator FED53_16570 ENOG4105KVH Transcriptional regulator FED53_16580 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FED53_16585 ENOG4105DAA L-lactate FED53_16590 ENOG4105ERH Fumarylacetoacetate hydrolase FED53_16595 ENOG4105C82 Malate synthase FED53_16600 ENOG4105CQB FAD linked oxidase domain protein FED53_16605 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FED53_16610 ENOG4105CQB FAD linked oxidase domain protein FED53_16615 ENOG4105JXH GntR family transcriptional regulator FED53_16620 ENOG4105N80 Ferric uptake regulator, Fur family FED53_16630 ENOG4108AEY RNA polymerase sigma factor FED53_16655 ENOG4105DRR Transcriptional regulator, GntR family FED53_16660 ENOG4105BZU Histidine kinase FED53_16670 ENOG4108QTI )-transporter FED53_16675 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FED53_16680 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FED53_16685 ENOG4108IFG nitrite reductase, (NAD(P)H) FED53_16690 ENOG4105DSE periplasmic solute binding protein FED53_16695 ENOG4105CC5 ABC transporter FED53_16700 ENOG4105DIK (ABC) transporter FED53_16730 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FED53_16735 ENOG4107QXV Phosphate transporter FED53_16740 ENOG4105E5W Transporter FED53_16750 ENOG4105CKI cobalamin synthesis protein FED53_16765 ENOG4105CPF Cell wall formation (By similarity) FED53_16800 ENOG4105CNA YD repeat protein FED53_16810 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FED53_16815 ENOG41082W1 Cupin 2, conserved barrel domain protein FED53_16845 ENOG4105EWC Purine nucleoside phosphorylase FED53_16905 ENOG4105C4R Atp-dependent dna helicase FED53_16935 ENOG4105W5Q DNA repair protein (RadC FED53_16945 ENOG4105EN2 IstB domain-containing protein ATP-binding protein FED53_16985 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FED53_16995 ENOG4105C6Z Gluconate FED53_17000 ENOG4105CMG Carbohydrate kinase FED53_17010 ENOG4106KNT transcriptional regulator FED53_17025 ENOG4108W5N phosphatidylglycerophosphatase a FED53_17040 ENOG4108ZMI UPF0477 protein FED53_17060 ENOG4105H67 Protein of unknown function (DUF421) FED53_17070 ENOG4105ENA helicase FED53_17125 ENOG4105CJW magnesium transporter FED53_17130 ENOG4107S1Q Phosphatase FED53_17135 ENOG4105EMS pseudouridine synthase FED53_17140 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FED53_17155 ENOG4105MIX Adenylate cyclase FED53_17160 ENOG4105E4C Lytic transglycosylase catalytic FED53_17165 ENOG4108Z18 K06886 hemoglobin FED53_17170 ENOG4105T58 Dithiol-disulfide isomerase FED53_17175 ENOG4105DPN Oligoendopeptidase f FED53_17185 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FED53_17195 ENOG4108ZCF integral membrane protein FED53_17200 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FED53_17205 ENOG4105CW7 secretion protein, HlyD family FED53_17220 ENOG4108JQ7 (ABC) transporter FED53_17230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FED53_17235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FED53_17240 ENOG4108J59 Extracellular solute-binding protein, family 5 FED53_17245 ENOG4105C31 Tryptophanyl-tRNA synthetase FED53_17250 ENOG4108KU1 UPF0736 protein FED53_17260 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FED53_17265 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FED53_17295 ENOG4105C4C beta-galactosidase FED53_17300 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase FED53_17305 ENOG4105CMR udp-glucose 4-epimerase FED53_17310 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FED53_17325 ENOG4107RUZ Sss sodium solute transporter superfamily FED53_17330 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FED53_17340 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FED53_17350 ENOG4105DBV ornithine carbamoyltransferase FED53_17360 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FED53_17370 ENOG4105CAS nag kinase FED53_17375 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FED53_17380 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FED53_17385 ENOG4105VG1 fes assembly suf system protein FED53_17395 ENOG4107AYK membrAne FED53_17400 ENOG4105EPR degv family FED53_17410 ENOG4105QNR S1 RNA binding domain protein FED53_17415 ENOG4108VPT UPF0234 protein FED53_17420 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FED53_17425 ENOG4108JUB Transcriptional regulator FED53_17435 ENOG4105C8Y Acetylornithine aminotransferase FED53_17440 ENOG4105C26 Dehydrogenase FED53_17445 ENOG4105FKQ transcriptional regulator FED53_17450 ENOG4108IUK alpha amylase, catalytic FED53_17460 ENOG4108YZA Nitrogen regulatory protein pii FED53_17470 ENOG4105CAQ asparagine synthetase FED53_17520 ENOG4105EYH Exonuclease FED53_17530 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FED53_17540 ENOG4105CHR reductase FED53_17620 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FED53_17625 ENOG4105E39 Enoyl-CoA hydratase FED53_17630 ENOG4105CEY Amp-dependent synthetase and ligase FED53_17635 ENOG4105DF9 Lipoate-protein, ligase FED53_17640 ENOG4108RQ5 Beta-lactamase domain-containing protein FED53_17645 ENOG4106AXD FED53_17655 ENOG4105D9N nucleoside FED53_17660 ENOG41075H3 AraC family transcriptional regulator FED53_17665 ENOG4105C2F Histidine kinase FED53_17675 ENOG4107RF6 penicillin-binding protein FED53_17685 ENOG4105C1Q protoporphyrinogen oxidase FED53_17690 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FED53_17695 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FED53_17700 ENOG4105BZ4 penicillin-binding protein FED53_17705 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FED53_17740 ENOG4105K59 histidine triad (HIT) protein FED53_17745 ENOG4107YB6 acetyltransferase, (GNAT) family FED53_17750 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FED53_17755 ENOG4105NBU tryptophan transport protein FED53_17765 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) FED53_17790 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FED53_17800 ENOG4105EQI Metal Dependent Phosphohydrolase FED53_17805 ENOG4105RHA ABC transporter, permease FED53_17810 ENOG4108IUX (ABC) transporter FED53_17825 ENOG4105CGU Enoyl-CoA hydratase FED53_17830 ENOG4105CEY Amp-dependent synthetase and ligase FED53_17835 ENOG4105D4P Coproporphyrinogen iii oxidase FED53_17850 ENOG4105DVE abc transporter atp-binding protein FED53_17860 ENOG4105WZB UPF0342 protein FED53_17870 ENOG410839P FED53_17880 ENOG410839P FED53_17885 ENOG410839P FED53_17910 ENOG4105YWU small acid-soluble spore protein FED53_17925 ENOG4105DWF phosphomethylpyrimidine kinase FED53_17930 ENOG4105D06 uba thif-type nad fad binding protein FED53_17935 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FED53_17945 ENOG41080HI glycine oxidase FED53_17950 ENOG4108VEU Thiamine monophosphate synthase FED53_17965 ENOG4105DRP amino acid AbC transporter FED53_17970 ENOG4105CDA abc transporter atp-binding protein FED53_17980 ENOG4105ED1 spovr family FED53_18000 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FED53_18005 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FED53_18015 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FED53_18020 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FED53_18030 ENOG4108YBP pseudouridine synthase FED53_18040 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FED53_18050 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FED53_18070 ENOG4108IJ9 (ABC) transporter FED53_18075 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FED53_18080 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FED53_18085 ENOG4108JUB Transcriptional regulator FED53_18090 ENOG4105CY2 Citrate transporter FED53_18095 ENOG4105EU9 FED53_18100 ENOG4107T5V SNARE associated Golgi FED53_18105 ENOG4108REF Sporulation integral membrane protein ytvi FED53_18115 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FED53_18130 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FED53_18145 ENOG4105E1K spore germination protein FED53_18150 ENOG4105DJ4 phosphatidylserine decarboxylase FED53_18160 ENOG4105RV9 Transcriptional regulator FED53_18165 ENOG4106AKX UPF0229 protein FED53_18170 ENOG4105CYN Serine protein kinase FED53_18175 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FED53_18185 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FED53_18200 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 FED53_18305 ENOG4105TUA UPF0295 protein FED53_18310 ENOG4105G5W regulator Fur family FED53_18315 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FED53_18335 ENOG4108IUW ABC transporter FED53_18340 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FED53_18345 ENOG4107NBY Membrane FED53_18355 ENOG4105BZ1 (ABC) transporter FED53_18375 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FED53_18380 ENOG4106BXE FED53_18385 ENOG4105CEN a g-specific adenine glycosylase FED53_18390 ENOG41067AE Membrane-bound metal-dependent hydrolase FED53_18400 ENOG4105XHU Acid-soluble spore protein K FED53_18410 ENOG4108IXY short-chain dehydrogenase reductase FED53_18440 ENOG4105ECP epimerase FED53_18465 ENOG4105C94 Transporter FED53_18475 ENOG4105C8Q Methyl-accepting chemotaxis FED53_18480 ENOG4108TVJ Nitroreductase FED53_18490 ENOG410829K Lysine exporter protein (Lyse ygga) FED53_18495 ENOG4108RCM Nitroreductase FED53_18510 ENOG4105EFI regulatoR FED53_18515 ENOG4105BZU Histidine kinase FED53_18520 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FED53_18525 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FED53_18530 ENOG4105C85 amino acid FED53_18555 ENOG4105CDA abc transporter atp-binding protein FED53_18560 ENOG4105E5Q amino acid AbC transporter FED53_18585 ENOG4105VUN Transcriptional regulator FED53_18645 ENOG4105DY9 regulatoR FED53_18655 ENOG4105CR4 methylisocitrate lyase FED53_18660 ENOG4105DXD 2-methylcitrate dehydratase FED53_18685 ENOG4105M6F mutator MutT protein FED53_18705 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FED53_18710 ENOG4108Z0Z intracellular protease Pfpi family FED53_18720 ENOG4105DEN Luciferase family FED53_18730 ENOG4105WAB arsR family transcriptional regulator FED53_18750 ENOG4108V06 Glutathione peroxidase FED53_18770 ENOG4105ST3 Transcriptional regulator FED53_18780 ENOG4108UMN azlc family FED53_18795 ENOG4108Z7R Chaperone CsaA FED53_18800 ENOG4108RNG Permease of the drug metabolite transporter FED53_18805 ENOG4105FTV AraC Family Transcriptional Regulator FED53_18810 ENOG4105BZW Glycerate kinase FED53_18815 ENOG4107QQ0 gntp family FED53_18820 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FED53_18825 ENOG4107R11 Transcriptional regulator FED53_18830 ENOG4105D2S major facilitator superfamily FED53_18840 ENOG4105VMP Transcriptional regulator FED53_18875 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FED53_18910 ENOG4105UPD Calcium Proton FED53_18915 ENOG410606W general stress protein FED53_18920 ENOG4105E5K Alpha-amylase FED53_18925 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FED53_18960 ENOG4108ISG Major Facilitator FED53_18965 ENOG4105PGM cation diffusion facilitator family transporter FED53_18970 ENOG4105KTU Transcriptional regulator, arsr family FED53_18980 ENOG4105C59 p-type ATPase FED53_18985 ENOG4107U9T Pfam:Ribonuclease_BN FED53_18995 ENOG4105KJF protein tyrosine phosphatase FED53_19000 ENOG41068PA UPF0435 protein FED53_19005 ENOG4105CPN adenine deaminase FED53_19010 ENOG4105K4I Scp-like extracellular FED53_19020 ENOG4107RKG DJ-1/PfpI family FED53_19025 ENOG4105BZG amino acid carrier protein FED53_19035 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FED53_19050 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FED53_19055 ENOG4105C5H ABC transporter FED53_19070 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FED53_19080 ENOG4108K8S endonuclease I FED53_19125 ENOG4108IBT Inherit from COG: transposase FED53_19135 ENOG4105FDU atp-dependent rna helicase FED53_19155 ENOG4105BZU Histidine kinase FED53_19165 ENOG4105D7N magnesium and cobalt transport protein CorA FED53_19175 ENOG4105BZG amino acid carrier protein FED53_19190 ENOG4108Z0Z intracellular protease Pfpi family FED53_19195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FED53_19200 ENOG41062D9 Histidine kinase FED53_19225 ENOG4105EA8 2-Nitropropane dioxygenase FED53_19230 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FED53_19235 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FED53_19240 ENOG4105BZU Histidine kinase FED53_19245 ENOG4107RMD Basic membrane lipoprotein FED53_19255 ENOG4105FE9 pseudouridine synthase FED53_19260 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FED53_19265 ENOG4105E2Z phosphate ABC transporter (Permease FED53_19270 ENOG4105C8U phosphate abc transporter FED53_19275 ENOG4105CVA phosphate FED53_19280 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FED53_19285 ENOG4105CBD Diacylglycerol kinase FED53_19290 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FED53_19295 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FED53_19300 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FED53_19315 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FED53_19320 ENOG4105C4R Atp-dependent dna helicase FED53_19325 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) FED53_19330 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FED53_19335 ENOG4105KGF protein, YerC YecD FED53_19350 ENOG4105C12 Phosphoribosylglycinamide synthetase FED53_19355 ENOG4105DC1 bifunctional purine biosynthesis protein purh FED53_19360 ENOG4108V3E phosphoribosylglycinamide formyltransferase FED53_19365 ENOG4105CXB phosphoribosylaminoimidazole synthetase FED53_19375 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FED53_19380 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FED53_19385 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FED53_19390 ENOG4105C8V SAICAR synthetase FED53_19395 ENOG4105C83 adenylosuccinate lyase FED53_19400 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FED53_19405 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FED53_19435 ENOG4105C7N Xanthine uracil vitamin C permease FED53_19440 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FED53_19455 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FED53_19465 ENOG4105KVH Transcriptional regulator FED53_19480 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FED53_19490 ENOG4108VA3 3-hexulose-6-phosphate synthase FED53_19520 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FED53_19525 ENOG4108TYN CAAX amino terminal protease family protein FED53_19535 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FED53_19540 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FED53_19545 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FED53_19550 ENOG4105C5H ABC transporter FED53_19555 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FED53_19560 ENOG410801F ribosomal-protein-alanine acetyltransferase FED53_19565 ENOG41072GX Peptidase M22 Glycoprotease FED53_19570 ENOG4105K8N protein family UPF0079, ATPase FED53_19670 ENOG41064BQ Phosphatase FED53_19685 ENOG4105WN5 stage II sporulation protein FED53_19690 ENOG4107SGM protein serine threonine phosphatase FED53_19695 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FED53_19700 ENOG4105FUA antagonist FED53_19705 ENOG4107MMM Anti-sigma-factor antagonist FED53_19710 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FED53_19720 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FED53_19725 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FED53_19730 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FED53_19745 ENOG4105C1J atp-dependent rna helicase FED53_19750 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FED53_19755 ENOG4105CPF Cell wall formation (By similarity) FED53_19765 ENOG4107RUE extracellular solute-binding protein family 1 FED53_19770 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component FED53_19775 ENOG4105F38 ABC transporter, permease FED53_19780 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FED53_19790 ENOG4107FQX Alpha-acetolactate decarboxylase FED53_19800 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FED53_19805 ENOG4105ETD TRANSCRIPTIONal FED53_19810 ENOG4105CTS PTS system mannitol-specific FED53_19820 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FED53_19825 ENOG4107QR9 Iron-sulfur cluster binding protein FED53_19830 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FED53_19835 ENOG4105JXH GntR family transcriptional regulator FED53_19840 ENOG4105DAA L-lactate FED53_19860 ENOG41067QW Transcriptional regulator FED53_19865 ENOG4107QJQ Mate efflux family protein FED53_19875 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FED53_19880 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FED53_19885 ENOG4107U5W ybbr family FED53_19890 ENOG4105C8B TIGR00159 family FED53_19900 ENOG4105EMN RNA polymerase sigma factor FED53_19975 ENOG4108NMV polysaccharide deacetylase FED53_19990 ENOG4105D1F ATP-binding protein FED53_20010 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FED53_20015 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FED53_20020 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FED53_20025 ENOG4108JJB ABC transporter FED53_20030 ENOG4108JJB ABC transporter FED53_20035 ENOG4108ZT0 50S ribosomal protein l17 FED53_20040 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FED53_20045 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FED53_20050 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FED53_20060 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FED53_20065 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FED53_20070 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FED53_20075 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FED53_20080 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FED53_20085 ENOG4105VPB 50S ribosomal protein L30 FED53_20090 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FED53_20100 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FED53_20105 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FED53_20110 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FED53_20120 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FED53_20125 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FED53_20130 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FED53_20135 ENOG41082SA 50s ribosomal protein l29 FED53_20140 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FED53_20145 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FED53_20150 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FED53_20155 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FED53_20160 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FED53_20165 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FED53_20170 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FED53_20175 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FED53_20185 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FED53_20195 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FED53_20200 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FED53_20205 ENOG4105XPM ribosomal protein FED53_20215 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FED53_20220 ENOG4107Y49 methyltransferase FED53_20225 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FED53_20230 ENOG4108VZM 50s ribosomal protein L10 FED53_20235 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FED53_20240 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FED53_20245 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FED53_20260 ENOG4105QIV RNA polymerase FED53_20265 ENOG4105M0M Tetracycline resistance protein FED53_20270 ENOG4105C2N RNA methyltransferase TrmH family group 3 FED53_20280 ENOG4105C8N cysteinyl-tRNA synthetase FED53_20285 ENOG4105D7W serine acetyltransferase FED53_20290 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FED53_20295 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FED53_20300 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FED53_20305 ENOG4105CTP PilT protein domain protein FED53_20310 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FED53_20315 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FED53_20325 ENOG41066A3 ATP guanido phosphotransferase FED53_20330 ENOG4108Z0C Uvrb UvrC protein FED53_20355 ENOG4108IUM Glycogen debranching enzyme FED53_20360 ENOG4105CRK lysyL-tRNA synthetase FED53_20365 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FED53_20370 ENOG4105KRF dihydroneopterin aldolase FED53_20375 ENOG4105EEI dihydropteroate synthase FED53_20380 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FED53_20385 ENOG4105DDQ anthranilate synthase FED53_20390 ENOG4105CRQ synthase (Component I) FED53_20395 ENOG4105C6T cysteine synthase FED53_20400 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FED53_20405 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FED53_20410 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FED53_20415 ENOG4108UGV hypoxanthine phosphoribosyltransferase FED53_20420 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FED53_20435 ENOG4105G3A stage ii sporulation protein e FED53_20450 ENOG41060GV RNA binding s1 domain protein FED53_20465 ENOG4105VYY sporulation protein yabp FED53_20470 ENOG41082I2 s4 domain protein FED53_20475 ENOG4108IY2 MazG family FED53_20485 ENOG4108M14 stage v sporulation protein t FED53_20490 ENOG4108JA2 transcriptioN-repair coupling factor FED53_20500 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FED53_20505 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FED53_20510 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FED53_20515 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FED53_20520 ENOG4105K4W Could be involved in septation (By similarity) FED53_20525 ENOG4105KME endoribonuclease L-psp FED53_20530 ENOG4105DFT pur operon repressor FED53_20545 ENOG4105W42 Veg protein FED53_20550 ENOG4105XFA sporulation peptidase YabG FED53_20555 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FED53_20560 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FED53_20565 ENOG4105F8V Hydrolase, tatD family FED53_20575 ENOG4105KRN Transcriptional regulator, abrb family FED53_20580 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FED53_20590 ENOG41060K3 Methyltransferase FED53_20595 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) FED53_20600 ENOG4105MA4 psp1 domain protein FED53_20605 ENOG4105FA2 dna polymerase iii FED53_20610 ENOG4105X0R protein from nitrogen regulatory protein P-II FED53_20615 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FED53_20620 ENOG4105CXN decarboxylase