locus-tag class description COP00_00050 ENOG4108FKH Transglycosylase SLT domain COP00_00070 ENOG41068G1 COP00_00090 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase COP00_00115 ENOG4105VTR Integrase COP00_00135 ENOG4108YM7 Gcn5-related n-acetyltransferase COP00_00170 ENOG4105C59 p-type ATPase COP00_00175 ENOG4105DC7 peptidase M24 COP00_00185 ENOG4105CID antiterminator COP00_00195 ENOG4105KRI phosphocarrier protein (HPr COP00_00200 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COP00_00210 ENOG4105F6S Spore photoproduct lyase COP00_00225 ENOG4105CHR reductase COP00_00230 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase COP00_00235 ENOG4105K4I Scp-like extracellular COP00_00245 ENOG4105BZU Histidine kinase COP00_00250 ENOG4105CHM Aminotransferase COP00_00265 ENOG4107R88 Chemotaxis protein (CheV) COP00_00270 ENOG4105UIN COP00_00280 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein COP00_00290 ENOG4105K6S Short-chain dehydrogenase reductase Sdr COP00_00295 ENOG4105EPM Diguanylate phosphodiesterase COP00_00300 ENOG4107IN1 Protein of unknown function (DUF1797) COP00_00310 ENOG4108XRC Protein of unknown function (DUF458) COP00_00340 ENOG4105NQC Flavodoxin COP00_00345 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) COP00_00360 ENOG4105D3R alkyl hydroperoxide reductase COP00_00365 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COP00_00380 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) COP00_00390 ENOG4105CVM Molybdenum cofactor synthesis domain protein COP00_00395 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein COP00_00400 ENOG4108ZAF Molybdopterin COP00_00405 ENOG41067WU Molybdopterin converting factor (Subunit 1) COP00_00415 ENOG4105BZ1 (ABC) transporter COP00_00420 ENOG4105BZ1 (ABC) transporter COP00_00430 ENOG4107X8C Efflux transporter RND family MFP subunit COP00_00435 ENOG4105C19 ABC transporter COP00_00440 ENOG4107RBB ABC transporter, permease COP00_00450 ENOG4105E98 transcriptional regulator DeoR family COP00_00455 ENOG4105DE4 1-phosphofructokinase COP00_00460 ENOG4105DM4 PTS System COP00_00465 ENOG4105C3F Signal peptidase i COP00_00480 ENOG4105C5H ABC transporter COP00_00505 ENOG4105BZU Histidine kinase COP00_00510 ENOG4107ZYR domain protein COP00_00520 ENOG4105CN5 Metallo-Beta-Lactamase COP00_00530 ENOG4108X4Q Hydrolase COP00_00535 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COP00_00555 ENOG4105CPP Dehydrogenase, E1 component COP00_00565 ENOG4107QN2 dihydrolipoyl dehydrogenase COP00_00580 ENOG4105CXN decarboxylase COP00_00585 ENOG4105WBI UPF0223 protein COP00_00600 ENOG4105ECY inositol monophosphatase COP00_00620 ENOG4105CI3 gtp-binding protein typa COP00_00625 ENOG4105QA2 COP00_00630 ENOG4108INS Transcriptional regulator COP00_00635 ENOG4107SCK Monooxygenase COP00_00650 ENOG4108IAB Phoh family COP00_00660 ENOG4105CSV Glutaminase COP00_00665 ENOG4105ZPI UPF0358 protein COP00_00670 ENOG4105CNI cell division protein FtsW COP00_00675 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COP00_00685 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) COP00_00695 ENOG4105BZ9 Cytochrome C oxidase, subunit I COP00_00700 ENOG4105CCU oxidase (Subunit III) COP00_00705 ENOG41064X9 cytochrome C oxidase subunit IV COP00_00720 ENOG41080XQ Signal transduction protein with cbs domains COP00_00725 ENOG4106UY4 Inherit from COG: Scp-like extracellular COP00_00755 ENOG4106H78 methyltransferase COP00_00760 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COP00_00765 ENOG4105H20 Sporulation integral membrane protein YlbJ COP00_00770 ENOG41063PX domain protein COP00_00775 ENOG4105CDE UPF0348 protein COP00_00780 ENOG4105KNH Nucleic acid-binding protein COP00_00785 ENOG41067VY 50S ribosomal protein L32 COP00_00805 ENOG41074B2 UPF0747 protein COP00_00810 ENOG4108V6E Cell division protein mraZ COP00_00815 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COP00_00825 ENOG4105CJN penicillin-binding protein COP00_00830 ENOG4105CJN penicillin-binding protein COP00_00835 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COP00_00840 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COP00_00845 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COP00_00850 ENOG4105CNI cell division protein FtsW COP00_00855 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COP00_00860 ENOG4105D4A Cell wall formation (By similarity) COP00_00865 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) COP00_00870 ENOG4108R2U division initiation protein COP00_00880 ENOG4105K67 small basic protein COP00_00885 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) COP00_00890 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COP00_00905 ENOG4105FFI sigma-e processing peptidase spoiiga COP00_00910 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COP00_00920 ENOG4105DKW ABC transporter COP00_00925 ENOG4105DHI Methyltransferase COP00_00930 ENOG4105WR5 sporulation protein, YlmC YmxH family COP00_00935 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase COP00_00940 ENOG4105DFA alanine racemase domain protein COP00_00945 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COP00_00950 ENOG41067XK integral membrane protein COP00_00955 ENOG4105DBK s4 domain protein COP00_00975 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COP00_00980 ENOG4105C34 Pseudouridine synthase COP00_00985 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COP00_00995 ENOG4105CXT aspartate transcarbamylase COP00_01000 ENOG4105CD3 dihydroorotase COP00_01005 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain COP00_01010 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain COP00_01015 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COP00_01020 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) COP00_01040 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) COP00_01060 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COP00_01065 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein COP00_01070 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein COP00_01075 ENOG4105F23 Fibronectin-binding protein COP00_01085 ENOG4105DSJ YicC domain protein COP00_01090 ENOG4105KC4 UPF0296 protein COP00_01095 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) COP00_01100 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COP00_01105 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase COP00_01110 ENOG4105C25 Primosomal protein n' COP00_01115 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COP00_01120 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COP00_01125 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B COP00_01130 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COP00_01135 ENOG4108ZF3 Phosphatase COP00_01140 ENOG4105D9P serine threonine protein kinase COP00_01145 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COP00_01150 ENOG4105DJV ribulose-phosphate 3-epimerase COP00_01155 ENOG4105FJ0 thiamine COP00_01165 ENOG4105VB9 50S ribosomal protein l28 COP00_01170 ENOG4108ZAA Alkaline-shock protein COP00_01175 ENOG4105DP4 dak2 domain fusion protein ylov COP00_01185 ENOG4105EJQ L-serine dehydratase COP00_01190 ENOG4105CB5 ATP-dependent DNA helicase recG COP00_01195 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) COP00_01200 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COP00_01205 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase COP00_01210 ENOG4105CHR reductase COP00_01215 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) COP00_01220 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COP00_01230 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COP00_01235 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COP00_01245 ENOG4105K5M 30s ribosomal protein S16 COP00_01250 ENOG4108BW8 UPF0109 protein COP00_01260 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COP00_01265 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) COP00_01270 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COP00_01275 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COP00_01280 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COP00_01290 ENOG4105VM1 flagellar COP00_01295 ENOG4105CMV Succinyl-CoA synthetase subunit beta COP00_01300 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha COP00_01305 ENOG4105C79 DNA protecting protein DprA COP00_01310 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COP00_01315 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COP00_01320 ENOG4108HE4 integrase family COP00_01325 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) COP00_01330 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) COP00_01335 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) COP00_01340 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) COP00_01345 ENOG4108ZC9 flagellar basal-body rod protein flgc COP00_01350 ENOG4105VQ0 flagellar hook-basal body complex protein fliE COP00_01355 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) COP00_01360 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) COP00_01375 ENOG4106YF4 Flagellar biosynthesis chaperone COP00_01385 ENOG410696Y Flagellar hook-length control protein COP00_01390 ENOG410822I Flagellar hook capping protein COP00_01395 ENOG4108JQA flagellar COP00_01400 ENOG41068WV flagellar FlbD family protein COP00_01410 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) COP00_01415 ENOG4105DD5 Flagellar motor switch protein COP00_01420 ENOG4107YTP response regulator receiver protein COP00_01430 ENOG4105CN7 Flagellar biosynthetic protein FliP COP00_01435 ENOG4105VS8 Flagellar biosynthetic protein fliq COP00_01440 ENOG4105D19 Role in flagellar biosynthesis (By similarity) COP00_01445 ENOG4105D00 flagellar biosynthetic protein flhB COP00_01450 ENOG4105D7B Flagellar biosynthesis protein flha COP00_01455 ENOG4105FZW flagellar biosynthesis regulator FlhF COP00_01465 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) COP00_01470 ENOG4105CBS Chea signal transduction histidine kinase COP00_01475 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis COP00_01485 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) COP00_01490 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COP00_01500 ENOG4105CE9 30S ribosomal protein S2 COP00_01505 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COP00_01515 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COP00_01520 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COP00_01525 ENOG4105KNE Phosphatidate cytidylyltransferase COP00_01535 ENOG4105DZP Membrane-associated zinc metalloprotease COP00_01545 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COP00_01560 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) COP00_01565 ENOG4105CHV Transcription elongation factor NusA COP00_01570 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination COP00_01575 ENOG4105VHM ribosomal protein COP00_01580 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COP00_01585 ENOG4105W7A Protein of unknown function (DUF503) COP00_01590 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COP00_01595 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COP00_01600 ENOG4105DTN riboflavin biosynthesis protein ribF COP00_01605 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COP00_01610 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COP00_01620 ENOG4105C1V Peptidase, M16 COP00_01635 ENOG4108S0H Dipicolinic acid synthetase, b subunit COP00_01640 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COP00_01650 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COP00_01665 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit COP00_01675 ENOG4105CNU cell division protein FtsK COP00_01680 ENOG4105FDP GntR family transcriptional regulator COP00_01700 ENOG4108RKS Short-chain dehydrogenase reductase Sdr COP00_01705 ENOG4105XZV Protein of unknown function (DUF3243) COP00_01720 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COP00_01730 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COP00_01740 ENOG4105D48 metallophosphoesterase COP00_01745 ENOG4105MCT stage V sporulation protein S COP00_01750 ENOG4108IGT Dipeptidase COP00_01755 ENOG4105CPQ Dehydrogenase COP00_01760 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) COP00_01765 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COP00_01780 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COP00_01785 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COP00_01790 ENOG4108RZ2 Glycoside hydrolase family 16 COP00_01800 ENOG4105UA4 acetyltransferase COP00_01885 ENOG4105C7F AcnD-accessory protein PrpF COP00_01890 ENOG4108J20 pectate lyase COP00_01895 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase COP00_01910 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase COP00_01915 ENOG4108Z66 YbaK ebsC protein COP00_01935 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COP00_01965 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COP00_01980 ENOG4105XPP Protein of unknown function (DUF1275) COP00_01990 ENOG4108J8C transporter major facilitator family protein COP00_01995 ENOG4105C0W non-ribosomal peptide synthetase COP00_02000 ENOG4105CEY Amp-dependent synthetase and ligase COP00_02015 ENOG41080BT SNARE associated Golgi COP00_02020 ENOG4105FQP Beta-lactamase COP00_02025 ENOG41087PP glycosyltransferase MGT family COP00_02030 ENOG4107QTZ amino acid COP00_02045 ENOG4105VRS hydrolase family 18 COP00_02050 ENOG4105M4P Tetr family transcriptional regulator COP00_02055 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein COP00_02060 ENOG4107S9F NmrA family COP00_02065 ENOG4108X3M OsmC Ohr family protein COP00_02070 ENOG4107E54 Small Multidrug Resistance protein COP00_02090 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COP00_02095 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) COP00_02105 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) COP00_02110 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COP00_02115 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COP00_02120 ENOG4105U6W MutT NUDIX family protein COP00_02125 ENOG4105DRR Transcriptional regulator, GntR family COP00_02185 ENOG4106F1P AAA ATPase, central domain protein COP00_02205 ENOG4106BHF COP00_02210 ENOG4106ANW SMI1_KNR4 COP00_02220 ENOG4106ANW SMI1_KNR4 COP00_02260 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase COP00_02285 ENOG4105E4C Lytic transglycosylase catalytic COP00_02290 ENOG4105E4C Lytic transglycosylase catalytic COP00_02295 ENOG4105E4C Lytic transglycosylase catalytic COP00_02400 ENOG41068G1 COP00_02495 ENOG4106QVS COP00_02510 ENOG4105K70 DNA-binding protein COP00_02585 ENOG4108NE4 COP00_02625 ENOG4107NTZ COP00_02685 ENOG4107D0N COP00_02800 ENOG4108J9Q DNA ligase COP00_02980 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) COP00_02985 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COP00_02990 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COP00_03000 ENOG4105DVF Cytosine-specific methyltransferase COP00_03005 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COP00_03010 ENOG4106ITI Glutaredoxin COP00_03030 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COP00_03045 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COP00_03100 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) COP00_03110 ENOG4106F1P AAA ATPase, central domain protein COP00_03115 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COP00_03120 ENOG4105CXI aluminum resistance protein COP00_03125 ENOG4105KV4 Transcriptional regulator COP00_03130 ENOG4105C5F glutamine synthetase COP00_03135 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COP00_03155 ENOG4108ZUE Phage regulatory protein rha COP00_03255 ENOG4105CAR Terminase, large subunit COP00_03270 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COP00_03315 ENOG4108FKH Transglycosylase SLT domain COP00_03325 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj COP00_03335 ENOG41068G1 COP00_03395 ENOG4105GIG COP00_03410 ENOG4105NCW Trka-c domain protein COP00_03415 ENOG4107S91 Sodium hydrogen exchanger COP00_03440 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COP00_03450 ENOG4105CAT Cytidine monophosphate kinase COP00_03500 ENOG4108MK9 spermidine N(1)-acetyltransferase COP00_03535 ENOG41062JF Transcriptional regulator COP00_03555 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COP00_03575 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COP00_03585 ENOG4108SVB resolvase COP00_03590 ENOG4105VPS UPF0291 protein COP00_03595 ENOG4105CV1 Transketolase (EC 2.2.1.1) COP00_03605 ENOG4105VXM UPF0154 protein COP00_03615 ENOG4107QIV Cytochrome c biogenesis protein COP00_03640 ENOG41076DU acid-soluble spore protein P COP00_03650 ENOG4108I0Z Aconitate hydratase COP00_03655 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COP00_03670 ENOG41067CD Small, acid-soluble spore protein Tlp COP00_03680 ENOG4105MI2 COP00_03685 ENOG4105W8X HesB YadR YfhF-family protein COP00_03690 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COP00_03695 ENOG4105K4P CoA-binding domain protein COP00_03700 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COP00_03710 ENOG4105CMD Transcriptional regulator, GntR family COP00_03725 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) COP00_03730 ENOG4107QNK )-transporter COP00_03735 ENOG4105CHR reductase COP00_03760 ENOG4105R3A Nitrate reductase COP00_03765 ENOG4108IUE nitrate reductase beta subunit COP00_03800 ENOG4107V6Q Cyclic nucleotide-binding domain COP00_03820 ENOG4105DSQ Nitric oxide reductase COP00_03830 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) COP00_03835 ENOG4106U2H Protein of unknown function (DUF1360) COP00_03840 ENOG4107QWR cellulase (EC 3.2.1.4) COP00_03850 ENOG4108428 Inherit from COG: -acetyltransferase COP00_03870 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) COP00_03880 ENOG4108UXE Protein tyrosine phosphatase COP00_03885 ENOG4105D6J arsenicaL-resistance protein COP00_03890 ENOG41082YX Transcriptional regulator, arsr family COP00_03895 ENOG4108V4B ThiJ pfpI COP00_03925 ENOG4105KMT branched-chain amino acid COP00_03930 ENOG4108UMN azlc family COP00_03935 ENOG4107U9B transcriptional regulator COP00_03955 ENOG41060WC Enoyl-CoA hydratase COP00_03960 ENOG4105C26 Dehydrogenase COP00_03965 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase COP00_03970 ENOG4105C1G acyl-Coa dehydrogenase COP00_03980 ENOG4105W1Y Transcriptional regulator COP00_03995 ENOG4105DQ4 alcohol dehydrogenase COP00_04000 ENOG4108Y4K DNA-binding transcriptional activator COP00_04010 ENOG41090UD (LipO)protein COP00_04050 ENOG4105DG6 mannose-6-phosphate isomerase COP00_04065 ENOG4107QIV Cytochrome c biogenesis protein COP00_04070 ENOG4105VCH membrane COP00_04095 ENOG4105DVE abc transporter atp-binding protein COP00_04100 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family COP00_04115 ENOG4105ST3 Transcriptional regulator COP00_04125 ENOG4105CSC Glucose uptake protein COP00_04135 ENOG4105F32 YngK protein COP00_04145 ENOG4105F1A Pyruvate formate-lyase COP00_04150 ENOG4105C6N Formate acetyltransferase COP00_04170 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family COP00_04200 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) COP00_04205 ENOG4107QX3 carboxylase COP00_04210 ENOG4105E39 Enoyl-CoA hydratase COP00_04215 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase COP00_04220 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit COP00_04225 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase COP00_04230 ENOG4105CEY Amp-dependent synthetase and ligase COP00_04235 ENOG4105C1G acyl-Coa dehydrogenase COP00_04240 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein COP00_04245 ENOG4105KVH Transcriptional regulator COP00_04280 ENOG4105H67 Protein of unknown function (DUF421) COP00_04290 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) COP00_04295 ENOG41061P3 phosphosulfolactate synthase COP00_04305 ENOG4105DIA mandelate racemase muconate lactonizing COP00_04310 ENOG4107RCC Major Facilitator Superfamily COP00_04330 ENOG4105BZ8 glutamate synthase COP00_04335 ENOG4105CBC glutamate synthase COP00_04365 ENOG4105BZ1 (ABC) transporter COP00_04370 ENOG4105DGI Alkaline phosphatase COP00_04385 ENOG4105C0R drug resistance transporter emrb qaca subfamily COP00_04390 ENOG4108J2R molybdopterin oxidoreductase COP00_04395 ENOG4105I03 Flagellin COP00_04410 ENOG4108Q8B Spore germination protein COP00_04415 ENOG4108NHD germination protein COP00_04420 ENOG4108Q8B Spore germination protein COP00_04425 ENOG4108Q8B Spore germination protein COP00_04460 ENOG4105C8Q Methyl-accepting chemotaxis COP00_04465 ENOG4108Z7R Chaperone CsaA COP00_04470 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin COP00_04480 ENOG4108RZE Tetr family transcriptional regulator COP00_04495 ENOG4108W8B Beta-lactamase domain protein COP00_04515 ENOG4105D29 Helix-turn-helix type 11 domain protein COP00_04525 ENOG4105KTU Transcriptional regulator, arsr family COP00_04535 ENOG4105CUB amino acid COP00_04545 ENOG4105C5E polysaccharide biosynthesis protein COP00_04565 ENOG4108SJC Membrane COP00_04580 ENOG41068WN COP00_04595 ENOG41069ER domain protein COP00_04600 ENOG4105C9U ATP-dependent DNA helicase RecQ COP00_04680 ENOG4105ECR NmrA family COP00_04700 ENOG4105EWI Short-chain dehydrogenase reductase Sdr COP00_04705 ENOG4105DDN Pentapeptide repeat-containing protein COP00_04720 ENOG410829K Lysine exporter protein (Lyse ygga) COP00_04725 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COP00_04790 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) COP00_04795 ENOG4105SCY DNAK suppressor COP00_04800 ENOG4105F0F Oxalate decarboxylase COP00_04820 ENOG4105EVH UPF0753 protein COP00_04825 ENOG4108TWJ NADH dehydrogenase subunit 5 COP00_04830 ENOG4105GPN Uncharacterized conserved protein (DUF2294) COP00_04850 ENOG4105C26 Dehydrogenase COP00_04870 ENOG4105CPC Aldo Keto reductase COP00_04875 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COP00_04880 ENOG4105GVJ transcriptional regulator COP00_04885 ENOG4105EWU Squalene--hopene cyclase COP00_04890 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) COP00_04895 ENOG4105C8J )-transporter COP00_04900 ENOG4105C09 Bile acid COP00_04905 ENOG4105C7S Dehydrogenase COP00_04910 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 COP00_04915 ENOG4107T89 von Willebrand factor, type A COP00_04920 ENOG4105GMT ATPase associated with various cellular activities aaa_5 COP00_04930 ENOG4105K4H Nlp p60 protein COP00_04955 ENOG4105FR1 rard protein COP00_04965 ENOG4108YQE rare lipoprotein a COP00_04975 ENOG4107EXU Short-chain dehydrogenase reductase Sdr COP00_04990 ENOG4105FBA Phospholipase Carboxylesterase COP00_05005 ENOG4105E1V na solute symporter COP00_05025 ENOG4108VXD carboxy-peptidase COP00_05030 ENOG4105D3A purine nucleoside phosphorylase DeoD-type COP00_05035 ENOG4108PJD permease COP00_05050 ENOG4106Z5R COP00_05055 ENOG410841Q phosphoesterase PA-phosphatase related protein COP00_05075 ENOG4105VSD UPF0346 protein COP00_05085 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein COP00_05090 ENOG4108TSC N-acetyltransferase COP00_05095 ENOG4107S4Y M20 DapE family protein YgeY COP00_05110 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COP00_05130 ENOG4105E0X reductase COP00_05165 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) COP00_05175 ENOG4108KF3 Electron transport protein SCO1 SenC COP00_05190 ENOG4105C7B Threonine dehydratase COP00_05200 ENOG4108UT2 hemolysin iii COP00_05210 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COP00_05225 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COP00_05230 ENOG4107YX5 Pfam:DUF548 COP00_05240 ENOG4105C01 Dihydroxy-acid dehydratase COP00_05255 ENOG4108V06 Glutathione peroxidase COP00_05260 ENOG4105CKU formyltetrahydrofolate synthetase COP00_05265 ENOG4105CVG Homoserine O-transsuccinylase COP00_05270 ENOG4108QBV Monogalactosyldiacylglycerol synthase COP00_05310 ENOG41081VK Ribonuclease COP00_05350 ENOG41065KQ synthase COP00_05360 ENOG4105C2W permease COP00_05365 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COP00_05370 ENOG4105CTD carboxy-peptidase COP00_05375 ENOG4105DVT helicase COP00_05390 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COP00_05400 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) COP00_05405 ENOG4108UKS UPF0398 protein COP00_05415 ENOG4107X2U Inherit from COG: Exonuclease-like protein COP00_05420 ENOG4108I5C dEAD DEAH box helicase COP00_05470 ENOG4105BZ4 penicillin-binding protein COP00_05480 ENOG4105CSM endonuclease III COP00_05495 ENOG4105CHM Aminotransferase COP00_05505 ENOG4105YAC COP00_05510 ENOG4105DVT helicase COP00_05515 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) COP00_05520 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COP00_05525 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) COP00_05535 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COP00_05540 ENOG4105CPK Glycosyl transferase (Group 1 COP00_05545 ENOG4105FJR Lmbe family COP00_05550 ENOG4108Z5K methylglyoxal synthase COP00_05555 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COP00_05560 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase COP00_05565 ENOG4108JYZ YitT family COP00_05585 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) COP00_05600 ENOG4108SXZ UPF0302 protein COP00_05605 ENOG41068YB TPR repeat-containing protein COP00_05620 ENOG4105CIH Imidazole acetol-phosphate transaminase COP00_05625 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) COP00_05630 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COP00_05640 ENOG4105DK0 Indole-3-glycerol phosphate synthase COP00_05645 ENOG4108I0Q anthranilate phosphoribosyltransferase COP00_05650 ENOG4105CRQ synthase (Component I) COP00_05655 ENOG4105KHN chorismate mutase COP00_05660 ENOG4105D49 3-dehydroquinate synthase COP00_05665 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase COP00_05670 ENOG4105BZU Histidine kinase COP00_05675 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COP00_05680 ENOG4105EAH synthase COP00_05685 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COP00_05690 ENOG4105XXQ heptaprenyl diphosphate synthase component I COP00_05700 ENOG4105EUJ GTP cyclohydrolase i COP00_05705 ENOG4105K70 DNA-binding protein COP00_05710 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) COP00_05730 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase COP00_05735 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COP00_05740 ENOG41065D1 COP00_05745 ENOG4105S2F COP00_05760 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COP00_05765 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COP00_05770 ENOG4105CAT Cytidine monophosphate kinase COP00_05780 ENOG4105MSI germination protein ypeb COP00_05795 ENOG4105HDK L-asparaginase COP00_05800 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase COP00_05815 ENOG4107RGJ metallophosphoesterase COP00_05830 ENOG4105I7S Abortive infection protein COP00_05835 ENOG4105C9U ATP-dependent DNA helicase RecQ COP00_05840 ENOG4105T7X COP00_05850 ENOG4108SAX Membrane COP00_05855 ENOG4108JQ1 Dehydrogenase COP00_05860 ENOG4105DR5 peptidase COP00_05875 ENOG4108KGH TRANSCRIPTIONal COP00_05890 ENOG4105US7 Histidine kinase COP00_05895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family COP00_05910 ENOG4105CRE cytochrome C COP00_05915 ENOG4107TWT Cytochrome c biogenesis protein COP00_05920 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COP00_05925 ENOG4105FE9 pseudouridine synthase COP00_05935 ENOG4108JIC nucleoside recognition domain protein COP00_05940 ENOG4105DZ1 carboxypeptidase COP00_05975 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COP00_05980 ENOG4108R6K riboflavin synthase, subunit alpha COP00_05985 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COP00_05995 ENOG4105MYT Heat shock protein COP00_06010 ENOG4107ZE5 PPIases accelerate the folding of proteins COP00_06015 ENOG4105PTM secreted protein COP00_06020 ENOG4105K7W phage-related replication protein COP00_06030 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COP00_06045 ENOG4105G6R Stage v sporulation protein ae COP00_06055 ENOG4105CZ3 stage V sporulation protein ad COP00_06060 ENOG41090VF Stage v sporulation protein ac COP00_06075 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COP00_06080 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) COP00_06085 ENOG41082AN stage II sporulation protein COP00_06090 ENOG4105DZ1 carboxypeptidase COP00_06095 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COP00_06100 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) COP00_06105 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COP00_06115 ENOG4105I3K Ferric uptake regulator, Fur family COP00_06120 ENOG4105MZ9 stage II sporulation protein m COP00_06125 ENOG4105CK1 PTS System COP00_06145 ENOG4107YB6 acetyltransferase, (GNAT) family COP00_06155 ENOG4108YZ4 nudix hydrolase COP00_06165 ENOG4105PF9 Transcriptional regulator COP00_06175 ENOG4105CPC Aldo Keto reductase COP00_06180 ENOG4105DXI Major Facilitator superfamily COP00_06185 ENOG4107U9B transcriptional regulator COP00_06190 ENOG4108M26 parallel beta-helix repeat protein COP00_06220 ENOG4106HZJ COP00_06230 ENOG4105RHY Pfam:UPF0157 COP00_06240 ENOG4108XET gCN5-related N-acetyltransferase COP00_06250 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold COP00_06275 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COP00_06290 ENOG4105E5W Transporter COP00_06295 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase COP00_06310 ENOG4105DA5 (ABC) transporter COP00_06340 ENOG4105K7W phage-related replication protein COP00_06345 ENOG4108IXY short-chain dehydrogenase reductase COP00_06350 ENOG41069FQ Metallo-beta-lactamase superfamily COP00_06355 ENOG4105II7 pyrroline-5-carboxylate reductase COP00_06365 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase COP00_06375 ENOG4105WDJ 50S ribosomal protein L33 COP00_06380 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) COP00_06385 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase COP00_06390 ENOG4108TZY GntR Family Transcriptional Regulator COP00_06395 ENOG4105CS2 ec 3.2.1.21 COP00_06400 ENOG4105CK1 PTS System COP00_06405 ENOG4105VCP PTS System COP00_06410 ENOG4105VZJ PTS System COP00_06415 ENOG4105G6Z alkaline phosphatase COP00_06420 ENOG4105H9W Short-chain dehydrogenase reductase Sdr COP00_06425 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COP00_06430 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COP00_06440 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) COP00_06450 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) COP00_06455 ENOG4108HNZ carboxyl transferase COP00_06460 ENOG4108QEG Membrane COP00_06465 ENOG4105CDA abc transporter atp-binding protein COP00_06470 ENOG4105E5Q amino acid AbC transporter COP00_06475 ENOG4108HW3 (ABC) transporter COP00_06480 ENOG4108Y6J UPF0403 protein COP00_06485 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) COP00_06490 ENOG4105C7S Dehydrogenase COP00_06495 ENOG4105CPP Dehydrogenase, E1 component COP00_06510 ENOG4105CKM Branched-chain carboxylic acid kinase COP00_06515 ENOG4107RDP Dehydrogenase COP00_06525 ENOG4108JUB Transcriptional regulator COP00_06530 ENOG4106CCJ Protein of unknown function (DUF2627) COP00_06535 ENOG4108QXE glycerophosphoryl diester phosphodiesterase COP00_06540 ENOG4105JQZ Methyltransferase COP00_06555 ENOG4107QQR Sporulation COP00_06560 ENOG4105S1Z Stage IV sporulation protein B COP00_06565 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) COP00_06570 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) COP00_06575 ENOG4105DX0 Hemolysin A COP00_06580 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COP00_06585 ENOG4105CTB Polyprenyl synthetase COP00_06590 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COP00_06595 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COP00_06600 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COP00_06605 ENOG4105M7K Involved in the transcription termination process (By similarity) COP00_06610 ENOG4108ZSR alkaline shock protein COP00_06615 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase COP00_06635 ENOG410644B Stage III sporulation protein af COP00_06645 ENOG4105KQ4 Stage iii sporulation protein ad COP00_06650 ENOG4108CQH stage III sporulation protein AC COP00_06655 ENOG4105KR5 Stage iii sporulation protein COP00_06660 ENOG4105CD2 stage iii sporulation protein aa COP00_06670 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COP00_06675 ENOG4105DC7 peptidase M24 COP00_06680 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COP00_06690 ENOG4105CBJ Metal-dependent enzyme COP00_06705 ENOG4105KST dependent repressor COP00_06710 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) COP00_06715 ENOG4105WZW rhodanese family COP00_06720 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COP00_06730 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) COP00_06735 ENOG4105C0D helicase COP00_06760 ENOG4105VFR signal peptidase COP00_06800 ENOG4106855 Competence protein COP00_06835 ENOG4105C5X domain protein COP00_06940 ENOG4105TMB Formate nitrite transporter COP00_06955 ENOG4105E0M Sulfatase COP00_06975 ENOG4107ZXI Rhomboid family COP00_06985 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase COP00_06990 ENOG4105WDJ 50S ribosomal protein L33 COP00_07010 ENOG41068DG YceG-like family COP00_07015 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COP00_07020 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COP00_07025 ENOG4105E2Z phosphate ABC transporter (Permease COP00_07030 ENOG4105C8U phosphate abc transporter COP00_07035 ENOG4105CVA phosphate COP00_07040 ENOG4107RF6 penicillin-binding protein COP00_07050 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) COP00_07055 ENOG4105SXS Protein of unknown function (DUF456) COP00_07070 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COP00_07075 ENOG41063Y9 COP00_07080 ENOG4108U5J '-nucleotidase COP00_07085 ENOG4105N80 Ferric uptake regulator, Fur family COP00_07095 ENOG4105FDK ABC transporter COP00_07100 ENOG4108JYZ YitT family COP00_07105 ENOG41069ZM Protein of unknown function (DUF2624) COP00_07110 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COP00_07125 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COP00_07130 ENOG4105EGD dinuclear metal center protein, YbgI family COP00_07140 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) COP00_07175 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COP00_07180 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COP00_07190 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COP00_07200 ENOG4105C38 Glycyl-tRNA synthetase beta subunit COP00_07205 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit COP00_07210 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) COP00_07220 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COP00_07230 ENOG4107YR5 Diacylglycerol kinase COP00_07235 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COP00_07240 ENOG4105CTJ Metal Dependent Phosphohydrolase COP00_07245 ENOG4105C9A Phoh family COP00_07250 ENOG4105EI1 sporulation protein yqfd COP00_07255 ENOG41068P3 sporulation protein YqfC COP00_07265 ENOG4105DI5 UPF0365 protein COP00_07270 ENOG4105F7J membrane-bound serine protease COP00_07275 ENOG4105KTH gatB Yqey COP00_07280 ENOG4105VCC 30S ribosomal protein S21 COP00_07290 ENOG4105VRR gCN5-related N-acetyltransferase COP00_07295 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COP00_07300 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COP00_07305 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) COP00_07310 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COP00_07315 ENOG4105CFG Acts as a chaperone (By similarity) COP00_07320 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COP00_07325 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COP00_07330 ENOG4105CSA Coproporphyrinogen iii oxidase COP00_07335 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COP00_07345 ENOG4108ZRV stage ii sporulation protein p COP00_07360 ENOG4105TQK DNA polymerase iii, delta' subunit COP00_07370 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 COP00_07375 ENOG4108UK2 deaminase COP00_07380 ENOG4105KQC Competence protein COP00_07390 ENOG4108D32 Methyltransferase COP00_07400 ENOG4108WF2 Metal Dependent Phosphohydrolase COP00_07405 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COP00_07410 ENOG410812S Rna-binding protein COP00_07415 ENOG4105E2X shikimate dehydrogenase COP00_07420 ENOG4105CQW ribosome biogenesis GTPase YqeH COP00_07425 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase COP00_07445 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) COP00_07450 ENOG4108JB9 formate dehydrogenase COP00_07465 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COP00_07485 ENOG4105EA8 2-Nitropropane dioxygenase COP00_07495 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COP00_07545 ENOG41090AA COP00_07565 ENOG4105EYF MMPL domain protein COP00_07570 ENOG4108VB1 regulatoR COP00_07575 ENOG4105ENE Histidine kinase COP00_07595 ENOG41080HJ 6-phospho 3-hexuloisomerase COP00_07620 ENOG4105WH1 Two component transcriptional regulator luxr family COP00_07625 ENOG4105BZU Histidine kinase COP00_07630 ENOG4105XXY Thioredoxin COP00_07635 ENOG41087NI Sulfite exporter TauE/SafE COP00_07645 ENOG4105VFE sira family COP00_07650 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase COP00_07655 ENOG4105XTG Pfam:DUF156 COP00_07680 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein COP00_07705 ENOG4105F8D glycoside hydrolase family 4 COP00_07710 ENOG4108HCJ Hydrolase COP00_07730 ENOG41083Q9 chitosanase COP00_07740 ENOG4105CAY ferredoxin--nadp reductase COP00_07750 ENOG4105EWI Short-chain dehydrogenase reductase Sdr COP00_07760 ENOG41090U3 tautomerase COP00_07775 ENOG4108MEK Metal-binding protein YodA COP00_07810 ENOG4105D82 Glutamate dehydrogenase COP00_07850 ENOG4108HKT sucrose-6-phosphate hydrolase COP00_07855 ENOG4105F3R pts system mannose fructose sorbose family iid COP00_07860 ENOG4105ETZ PTS System COP00_07865 ENOG4108IQ3 PTS system COP00_07870 ENOG4105YHU PTS system COP00_07875 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family COP00_07900 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COP00_07905 ENOG4105C85 amino acid COP00_07910 ENOG4105G7B Protein of unknown function (DUF2992) COP00_07915 ENOG4107RSM transcriptional regulator COP00_07920 ENOG4107Y9E nuclease COP00_07945 ENOG41068K0 YCII-related domain COP00_07960 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COP00_07975 ENOG4105KVH Transcriptional regulator COP00_07980 ENOG4105EXQ uroporphyrinogen iii synthase hem4 COP00_07990 ENOG4107RSM transcriptional regulator COP00_08005 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) COP00_08010 ENOG41082JN Transcriptional regulator COP00_08020 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin COP00_08050 ENOG4105C28 cystathionine COP00_08060 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COP00_08065 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) COP00_08080 ENOG4107XRG penicillin-binding protein COP00_08085 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COP00_08095 ENOG4105CFP Peptidase U32 COP00_08100 ENOG4105XYU peptidase (U32 family) COP00_08105 ENOG4108VQJ O-methyltransferase COP00_08110 ENOG4105HHA aminodeoxychorismate lyase COP00_08115 ENOG4105VPH UPF0473 protein COP00_08120 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COP00_08125 ENOG4105VBH UPF0297 protein COP00_08130 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COP00_08135 ENOG4105C02 permease COP00_08140 ENOG4105CDA abc transporter atp-binding protein COP00_08145 ENOG4105CT1 (ABC) transporter COP00_08150 ENOG4105EAD ABC transporter COP00_08155 ENOG4105DRP amino acid AbC transporter COP00_08165 ENOG41060CR COP00_08175 ENOG4105C7H Helicase, RecD TraA family COP00_08185 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COP00_08190 ENOG4105C3J Cysteine desulfurase COP00_08200 ENOG4105D1H recombination factor protein RarA COP00_08210 ENOG4105CUZ uba thif-type nad fad binding protein COP00_08220 ENOG4105C9M aspartyl-trna synthetase COP00_08225 ENOG4105CUT histidyl-tRNA synthetase COP00_08235 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase COP00_08240 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COP00_08245 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COP00_08250 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COP00_08255 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) COP00_08260 ENOG41067VP Protein of unknown function (DUF1049) COP00_08265 ENOG4105NCW Trka-c domain protein COP00_08270 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COP00_08280 ENOG4105CKP Polysaccharide Biosynthesis Protein COP00_08285 ENOG4108QG2 Membrane COP00_08290 ENOG4105NAP COP00_08295 ENOG4105VIE preprotein translocase, subunit YajC COP00_08300 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COP00_08305 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COP00_08310 ENOG41061AI Protein of unknown function (DUF2905) COP00_08315 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COP00_08320 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COP00_08335 ENOG41069DP small acid-soluble spore protein COP00_08345 ENOG4105K7W phage-related replication protein COP00_08360 ENOG4105CDY transcriptional regulatory protein COP00_08370 ENOG4106678 morphogenetic protein associated with SpoVID COP00_08380 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase COP00_08385 ENOG4108IYU L-aspartate oxidase COP00_08400 ENOG4105CQC Prephenate dehydratase COP00_08405 ENOG41090I5 UPF0735 ACT domain-containing protein COP00_08410 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COP00_08420 ENOG4105K46 50S ribosomal protein l27 COP00_08425 ENOG4105X36 (ribosomal) protein COP00_08430 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COP00_08450 ENOG41082BM Transcriptional regulator, arsr family COP00_08455 ENOG4107QMS site-determining protein COP00_08460 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) COP00_08465 ENOG4105YHC Rod shape-determining protein MreD COP00_08470 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) COP00_08475 ENOG4105DFF Rod shape-determining protein mreb COP00_08480 ENOG4105W5Q DNA repair protein (RadC COP00_08485 ENOG4108Z03 MAF-like protein COP00_08495 ENOG4106A3R peptidase COP00_08500 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase COP00_08515 ENOG4106AR7 Spore coat protein COP00_08520 ENOG41068KH stage VI sporulation protein D COP00_08525 ENOG41068KH stage VI sporulation protein D COP00_08530 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase COP00_08535 ENOG4105D52 delta-aminolevulinic acid dehydratase COP00_08545 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) COP00_08555 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COP00_08565 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) COP00_08570 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COP00_08575 ENOG4108IUQ atp-dependent protease COP00_08580 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COP00_08585 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COP00_08595 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COP00_08605 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COP00_08610 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COP00_08615 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase COP00_08620 ENOG4108ZP8 Acetolactate synthase small subunit COP00_08625 ENOG4105C7K acetolactate synthase COP00_08630 ENOG4105CM2 brancheD-chain amino acid aminotransferase COP00_08640 ENOG4107R37 Glutamate dehydrogenase COP00_08680 ENOG4105M59 Phosphodiesterase, mj0936 family COP00_08685 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COP00_08690 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COP00_08695 ENOG4108XJQ germination protein COP00_08700 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COP00_08705 ENOG41067TZ transcriptional regulator, MarR family COP00_08710 ENOG4105PFC Transcriptional regulator COP00_08715 ENOG4105EMU Dehydrogenase COP00_08725 ENOG4105E33 succinate dehydrogenase COP00_08735 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit COP00_08750 ENOG4105CFH Aspartokinase COP00_08760 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COP00_08765 ENOG4105K63 Thioredoxin COP00_08770 ENOG4105C10 Electron transfer flavoprotein COP00_08775 ENOG4105BZJ Electron transfer flavoprotein COP00_08780 ENOG41060WC Enoyl-CoA hydratase COP00_08785 ENOG4107Z3H Transcriptional regulator, TetR family COP00_08800 ENOG4105DYS nad(p)h dehydrogenase (quinone) COP00_08820 ENOG4105C98 muts2 protein COP00_08825 ENOG4105DCG PHP domain protein COP00_08835 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) COP00_08840 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COP00_08855 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) COP00_08860 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) COP00_08865 ENOG4108RWN rrna methyltransferase COP00_08870 ENOG41067MF small acid-soluble spore protein COP00_08880 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) COP00_08885 ENOG410905X membrane-flanked domain protein COP00_08890 ENOG4105CKV Membrane COP00_08905 ENOG4105DRS transport system, permease COP00_08920 ENOG4108MDK Dehydrogenase COP00_08925 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase COP00_08930 ENOG4105EF1 ribulokinase COP00_08935 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) COP00_08945 ENOG4105CN9 Peptidase m42 family protein COP00_08955 ENOG410696E Membrane COP00_08960 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COP00_08965 ENOG4105VJV 50s ribosomal protein L35 COP00_08970 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COP00_08975 ENOG41067MG lrgb family COP00_08985 ENOG4105DGI Alkaline phosphatase COP00_08990 ENOG4105DY9 regulatoR COP00_08995 ENOG4108HRK Histidine kinase COP00_09000 ENOG4105U0R haloacid dehalogenase-like hydrolase COP00_09005 ENOG4105C22 threonyL-tRNA synthetase COP00_09010 ENOG4108TDW sporulation protein YtxC COP00_09030 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COP00_09040 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) COP00_09045 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase COP00_09050 ENOG4108NR7 pectate lyase COP00_09055 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COP00_09065 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) COP00_09070 ENOG4105C2M dna polymerase I COP00_09075 ENOG4105BZU Histidine kinase COP00_09080 ENOG4105DPZ Two component transcriptional regulator (Winged helix family COP00_09085 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) COP00_09090 ENOG4108HMX isocitrate dehydrogenase (NADP) COP00_09095 ENOG4105BZN citrate synthase COP00_09100 ENOG4108VMM UPF0756 membrane protein COP00_09105 ENOG4108REF Sporulation integral membrane protein ytvi COP00_09110 ENOG4105FS0 cytoplasmic membrane protein COP00_09115 ENOG4105CA9 Pyruvate kinase COP00_09120 ENOG4105CTQ phosphohexokinase COP00_09125 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) COP00_09135 ENOG4105C6K Malic enzyme COP00_09140 ENOG4105C0B DNA polymerase III (alpha subunit) COP00_09145 ENOG4105VV2 COP00_09155 ENOG4106EVM COP00_09175 ENOG4105U3E Transcriptional regulator COP00_09180 ENOG4105E8R UPF0173 metal-dependent hydrolase COP00_09190 ENOG4105CH7 arginosuccinase COP00_09195 ENOG4105CDH Citrulline--aspartate ligase COP00_09200 ENOG4105EPU Molybdenum cofactor synthesis domain protein COP00_09205 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COP00_09215 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COP00_09220 ENOG4105KBJ sporulation protein ytfj COP00_09230 ENOG4105VK3 rdd domain containing protein COP00_09235 ENOG4105D07 Signal peptide peptidase, SppA COP00_09250 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) COP00_09260 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COP00_09290 ENOG4105U5Y Transcriptional regulator COP00_09300 ENOG4105BZU Histidine kinase COP00_09310 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COP00_09320 ENOG4105KAF membrAne COP00_09325 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COP00_09335 ENOG4105F1V Acetoin utilization protein COP00_09340 ENOG4105W87 Cbs domain COP00_09345 ENOG4105DGU Histone deacetylase COP00_09350 ENOG4105ER2 Ompa motb domain protein COP00_09355 ENOG4107R0U MotA TolQ exbB proton channel COP00_09360 ENOG4105ETE Transcriptional regulator (LacI family COP00_09365 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase COP00_09390 ENOG4105DFU Cell wall formation (By similarity) COP00_09400 ENOG4108VDD TRNA binding domain protein COP00_09415 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ COP00_09430 ENOG4105C6K Malic enzyme COP00_09435 ENOG4105C8F Beta-lactamase domain protein COP00_09440 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COP00_09450 ENOG4108V15 phosphotransferase enzyme family COP00_09465 ENOG4107F58 2'-5' rna ligase COP00_09470 ENOG4105C6T cysteine synthase COP00_09480 ENOG4107QSE Dipeptidase COP00_09485 ENOG4105C7N Xanthine uracil vitamin C permease COP00_09490 ENOG4105YW5 deoR family transcriptional regulator COP00_09505 ENOG4105CBX hi0933 family COP00_09515 ENOG4105E98 transcriptional regulator DeoR family COP00_09520 ENOG4105G63 Type III effector Hrp-dependent COP00_09525 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) COP00_09545 ENOG41085GJ domain protein COP00_09560 ENOG4105MU9 integral membrane protein COP00_09565 ENOG4105DDC Oxidoreductase domain protein COP00_09575 ENOG4105F5H Glycosyl Hydrolase Family 88 COP00_09595 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component COP00_09615 ENOG4107V2S Transcriptional regulator COP00_09620 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase COP00_09625 ENOG4105C8T Leucyl-tRNA synthetase COP00_09635 ENOG410605W Major Facilitator COP00_09650 ENOG4105D01 (LipO)protein COP00_09655 ENOG4106UBQ COP00_09660 ENOG4107R34 abc transporter permease protein COP00_09665 ENOG4105C19 ABC transporter COP00_09675 ENOG4105DVE abc transporter atp-binding protein COP00_09680 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family COP00_09690 ENOG4105N5T Radical SAM Protein COP00_09715 ENOG4108Z0R Transferase COP00_09720 ENOG4105YVM Phosphoesterase, PA-phosphatase related COP00_09725 ENOG4105BZF Glycosyl transferase (Group 1 COP00_09730 ENOG4105CAQ asparagine synthetase COP00_09735 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP COP00_09755 ENOG4105D2X ABC transporter substrate-binding protein COP00_09765 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component COP00_09790 ENOG4108RMU ferritin dps family protein COP00_09805 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COP00_09810 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COP00_09815 ENOG4108V2W Carbonate dehydratase COP00_09820 ENOG4105DSE periplasmic solute binding protein COP00_09850 ENOG4108PGP mmge prpd family protein COP00_09855 ENOG4105CH2 amidohydrolase COP00_09865 ENOG4108HW4 amino acid AbC transporter COP00_09870 ENOG4105EAB amino acid AbC transporter COP00_09875 ENOG4108XSB acetyltransferase, (GNAT) family COP00_09880 ENOG4105CPU Monooxygenase COP00_09885 ENOG4105DTQ mandelate racemase muconate lactonizing COP00_09890 ENOG4105CEY Amp-dependent synthetase and ligase COP00_09895 ENOG4108IPT Naphthoate synthase COP00_09905 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COP00_09910 ENOG4105E4F Isochorismate synthase COP00_09915 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase COP00_10045 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase COP00_10050 ENOG4105E8R UPF0173 metal-dependent hydrolase COP00_10070 ENOG4105CMD Transcriptional regulator, GntR family COP00_10075 ENOG4105N67 Proton-coupled thiamine transporter YuaJ COP00_10100 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COP00_10105 ENOG4106DF1 COP00_10110 ENOG4108VNY MOSC domain protein COP00_10115 ENOG4108JB8 alcohol dehydrogenase COP00_10120 ENOG4105C26 Dehydrogenase COP00_10125 ENOG4105TRT Transcriptional regulator COP00_10160 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) COP00_10200 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) COP00_10225 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COP00_10245 ENOG4105C8Q Methyl-accepting chemotaxis COP00_10250 ENOG4105C8Q Methyl-accepting chemotaxis COP00_10265 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme COP00_10280 ENOG4105C37 (CBS) domain COP00_10295 ENOG4107PBV potassium channel COP00_10300 ENOG4107PBV potassium channel COP00_10315 ENOG4107QYV phosphohexose isomerase COP00_10320 ENOG4107QW4 alcohol dehydrogenase COP00_10325 ENOG4105WG9 Conserved Protein COP00_10335 ENOG4105CHM Aminotransferase COP00_10340 ENOG4108ZB6 transcriptional regulator AsnC family COP00_10345 ENOG4108MUZ hydrolase COP00_10355 ENOG4105C87 Aminotransferase class I and II COP00_10365 ENOG4105Y38 Kinase-associated protein B COP00_10380 ENOG4105BZ4 penicillin-binding protein COP00_10385 ENOG4105KIR Thiol-disulfide oxidoreductase dcc COP00_10400 ENOG4108MRH transcriptional regulatory protein COP00_10405 ENOG4105DIH basic membrane COP00_10410 ENOG4108JQ9 ABC transporter COP00_10415 ENOG4105UIB (ABC) transporter COP00_10425 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase COP00_10430 ENOG4107ZTW SNARE associated Golgi COP00_10435 ENOG4105DJ4 phosphatidylserine decarboxylase COP00_10450 ENOG4105D65 subunit l COP00_10455 ENOG4105HC0 Na H antiporter COP00_10460 ENOG4108ZE9 Monovalent cation H antiporter subunit C COP00_10465 ENOG4108JPZ Monovalent cation H antiporter subunit D COP00_10470 ENOG4105SC1 monovalent cation H antiporter subunit E COP00_10480 ENOG4105KJM monovalent cation h antiporter subunit g COP00_10485 ENOG4105KA0 thioesterase Superfamily protein COP00_10495 ENOG4105BZU Histidine kinase COP00_10525 ENOG4105DAP Nicotinate phosphoribosyltransferase COP00_10550 ENOG4105C02 permease COP00_10575 ENOG410904N short-chain dehydrogenase reductase COP00_10615 ENOG4108K8K Transcriptional regulator COP00_10620 ENOG4105DCF alanine dehydrogenase COP00_10640 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) COP00_10650 ENOG41069ER domain protein COP00_10660 ENOG4105CEP NADH dehydrogenase COP00_10670 ENOG4105CAY ferredoxin--nadp reductase COP00_10700 ENOG4108YX9 iron--sulfur cluster insertion protein erpA COP00_10735 ENOG4105PY6 Phenolic acid decarboxylase COP00_10750 ENOG41083MR nifu domain-containing protein COP00_10760 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COP00_10765 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) COP00_10770 ENOG4105D6E homoserine dehydrogenase COP00_10775 ENOG4105C5I Dehydrogenase COP00_10785 ENOG4108W5N phosphatidylglycerophosphatase a COP00_10790 ENOG4105D4U had-superfamily hydrolase, subfamily iia COP00_10800 ENOG4105MMD transcriptional regulator COP00_10805 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) COP00_10810 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COP00_10815 ENOG4105FAA peptidase M23 COP00_10820 ENOG4108YTE sporulation protein YunB COP00_10825 ENOG4105KZD Domain of unknown function (DUF1805) COP00_10830 ENOG4107R8B 5'-nucleotidase COP00_10840 ENOG4105I3N Conserved Protein COP00_10845 ENOG4105IIP Membrane COP00_10850 ENOG4105W1N transcriptional regulator COP00_10860 ENOG4108K8S endonuclease I COP00_10865 ENOG4108IJ9 (ABC) transporter COP00_10870 ENOG4105FDP GntR family transcriptional regulator COP00_10875 ENOG4108KPW sugar kinase COP00_10880 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component COP00_10885 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component COP00_10890 ENOG4105XN3 extracellular solute-binding protein family 1 COP00_10895 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine COP00_10920 ENOG4105XRQ Xanthine dehydrogenase accessory factor COP00_10925 ENOG4107VFR oxidoreductase COP00_10945 ENOG4105DIW FeS assembly protein SUFB COP00_10950 ENOG4108UNV SUF system FeS assembly protein, NifU family COP00_10955 ENOG4105C9B Cysteine desulfurase COP00_10960 ENOG4105JRK feS assembly protein SufD COP00_10965 ENOG4105C3K feS assembly ATPase SufC COP00_10970 ENOG4105PGM cation diffusion facilitator family transporter COP00_10980 ENOG4105D01 (LipO)protein COP00_10985 ENOG4108UMI ABC transporter, permease COP00_10990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COP00_11015 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) COP00_11020 ENOG41080E8 Transcriptional regulator, Spx MgsR family COP00_11025 ENOG4105C1G acyl-Coa dehydrogenase COP00_11030 ENOG4105CHU acetyl-coa acetyltransferase COP00_11065 ENOG4105E0A ABC, transporter COP00_11070 ENOG4108IHU transport system permease protein COP00_11075 ENOG4105DQ5 transport system permease protein COP00_11080 ENOG4108MES Periplasmic binding protein COP00_11095 ENOG4105DZ1 carboxypeptidase COP00_11100 ENOG4105E1F short-chain dehydrogenase reductase COP00_11105 ENOG4105HUF DNA protection during starvation protein COP00_11110 ENOG4105C0H protease COP00_11120 ENOG4105F3H Histidine kinase COP00_11130 ENOG41067SE Tetr family transcriptional regulator COP00_11135 ENOG4105C9Q fumarate hydratase class II COP00_11165 ENOG4105WH1 Two component transcriptional regulator luxr family COP00_11170 ENOG4105ENE Histidine kinase COP00_11185 ENOG41087YS Phage shock protein A COP00_11210 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) COP00_11215 ENOG4108WBT adenosyltransferase COP00_11220 ENOG4105E0A ABC, transporter COP00_11225 ENOG4105EHG Permease protein COP00_11230 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) COP00_11235 ENOG4105EWI Short-chain dehydrogenase reductase Sdr COP00_11240 ENOG4108RPX mosc domain containing protein COP00_11245 ENOG4107RSM transcriptional regulator COP00_11260 ENOG4107QZW Altronate oxidoreductase COP00_11265 ENOG4107KJX Transcriptional regulator COP00_11275 ENOG4105D2H Uronic isomerase COP00_11285 ENOG4105DPZ Two component transcriptional regulator (Winged helix family COP00_11290 ENOG4105E0A ABC, transporter COP00_11295 ENOG4105EHG Permease protein COP00_11300 ENOG4105DQ5 transport system permease protein COP00_11305 ENOG4105D5Q Arginine ornithine antiporter COP00_11315 ENOG4107K5X Membrane-bound metal-dependent hydrolase COP00_11320 ENOG4107QZ2 Sulfatase COP00_11335 ENOG4105EVU fructokinase COP00_11340 ENOG4105EEQ Na H antiporter COP00_11345 ENOG4107EPV Aminotransferase class V COP00_11355 ENOG4105EEM helicase COP00_11360 ENOG4105EN6 Membrane COP00_11365 ENOG4105RHY Pfam:UPF0157 COP00_11370 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) COP00_11380 ENOG4107ZQN disulfide bond COP00_11385 ENOG4105C59 p-type ATPase COP00_11400 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component COP00_11405 ENOG4105CJQ hydrolase, family 31 COP00_11415 ENOG4105DIK (ABC) transporter COP00_11420 ENOG4105CC5 ABC transporter COP00_11425 ENOG4105DSE periplasmic solute binding protein COP00_11440 ENOG4105DE4 1-phosphofructokinase COP00_11445 ENOG4105DM4 PTS System COP00_11450 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN COP00_11455 ENOG4105D2N Aldolase COP00_11460 ENOG4105C59 p-type ATPase COP00_11465 ENOG410681U heavy metal transport detoxification protein COP00_11470 ENOG4105VPX protein, conserved in bacteria COP00_11475 ENOG4108Z0Z intracellular protease Pfpi family COP00_11480 ENOG4105E98 transcriptional regulator DeoR family COP00_11485 ENOG4105DET Rhamnulokinase COP00_11490 ENOG4105C9F isomerase COP00_11505 ENOG4105F27 Major Facilitator COP00_11510 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) COP00_11530 ENOG4105D9R oxidoreductase COP00_11540 ENOG4105C72 UPF0176 protein COP00_11550 ENOG4106DF4 Sigma-70, region 4 COP00_11560 ENOG4105F0F Oxalate decarboxylase COP00_11575 ENOG4108MYR Secreted protein COP00_11580 ENOG4107SYN Glycosyl hydrolases family 43 COP00_11625 ENOG41068G1 COP00_11645 ENOG4108FKH Transglycosylase SLT domain COP00_11690 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COP00_11705 ENOG4105CAR Terminase, large subunit COP00_11750 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin COP00_11865 ENOG4108IMY Transcriptional regulator COP00_11875 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COP00_11885 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COP00_11900 ENOG4105XZU Preprotein translocase, subunit SecG COP00_11925 ENOG4105R40 Glycine betaine carnitine choline COP00_11930 ENOG4108HQR Glycine betaine COP00_11935 ENOG4105E90 ABC transporter COP00_11940 ENOG4108IJ8 ABC transporter COP00_11945 ENOG4107HG4 Transcriptional regulator COP00_11950 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein COP00_11960 ENOG4105T65 Membrane-associated protein COP00_11965 ENOG4108MES Periplasmic binding protein COP00_11980 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COP00_11985 ENOG4105CP7 Triose-phosphate isomerase COP00_11990 ENOG4105BZA Phosphoglycerate kinase COP00_11995 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase COP00_12010 ENOG4105DEN Luciferase family COP00_12025 ENOG4105KIS phospholipid-binding protein COP00_12030 ENOG4108WAV Transcriptional regulator COP00_12045 ENOG4105WH1 Two component transcriptional regulator luxr family COP00_12065 ENOG4108Z5V transcriptional regulator, merr family COP00_12085 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) COP00_12090 ENOG4105JXH GntR family transcriptional regulator COP00_12095 ENOG4105DAA L-lactate COP00_12100 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COP00_12110 ENOG4108ZPC Polysaccharide pyruvyl transferase COP00_12115 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase COP00_12120 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family COP00_12125 ENOG4105D3Q Sugar transferase COP00_12135 ENOG4105K64 Glycosyl transferase, family 2 COP00_12145 ENOG4107QRS glycosyltransferase group 2 family protein COP00_12150 ENOG41068W6 Capsular polysaccharide biosynthesis protein COP00_12155 ENOG4108KMV Glycosyl transferase (Group 1 COP00_12160 ENOG4105K64 Glycosyl transferase, family 2 COP00_12165 ENOG4108PQP glycosyl transferase group 1 COP00_12175 ENOG4108QV3 biosynthesis protein COP00_12180 ENOG4105HTX biosynthesis protein COP00_12190 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein COP00_12195 ENOG4108I5G Major Facilitator superfamily COP00_12205 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) COP00_12210 ENOG4107S2N Type III effector Hrp-dependent COP00_12220 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COP00_12225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family COP00_12235 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase COP00_12240 ENOG4105EDQ levansucrase EC 2.4.1.10 COP00_12245 ENOG4108HKT sucrose-6-phosphate hydrolase COP00_12255 ENOG4106ANW SMI1_KNR4 COP00_12310 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase COP00_12325 ENOG41068G1 COP00_12345 ENOG4108FKH Transglycosylase SLT domain COP00_12390 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COP00_12460 ENOG4108J9Q DNA ligase COP00_12525 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COP00_12535 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COP00_12545 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COP00_12560 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COP00_12565 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) COP00_12590 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COP00_12605 ENOG4105C2M dna polymerase I COP00_12640 ENOG4108IMY Transcriptional regulator COP00_12720 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COP00_12730 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COP00_12735 ENOG4105ECQ AraC Family Transcriptional Regulator COP00_12745 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain COP00_12750 ENOG4107TVP HD domain protein COP00_12755 ENOG4105CHH sulfate transporter COP00_12760 ENOG4108V2W Carbonate dehydratase COP00_12765 ENOG4105C5I Dehydrogenase COP00_12770 ENOG4108SQ9 flavin reductase domain protein, FMN-binding COP00_12775 ENOG4108ZHR arsR family transcriptional regulator COP00_12785 ENOG4105C19 ABC transporter COP00_12790 ENOG4105EWM Histidine kinase COP00_12805 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase COP00_12810 ENOG4105KRI phosphocarrier protein (HPr COP00_12815 ENOG4105CIE May be required for sporulation (By similarity) COP00_12820 ENOG4105CHW UPF0052 protein COP00_12825 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) COP00_12830 ENOG4108Z4K mutator MutT protein COP00_12835 ENOG4105C3M thioredoxin reductase COP00_12845 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase COP00_12850 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) COP00_12855 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase COP00_12860 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) COP00_12865 ENOG4105ECC imidazole-glycerol-phosphate dehydratase COP00_12870 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) COP00_12875 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) COP00_12880 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) COP00_12895 ENOG4108E16 pectate lyase COP00_12900 ENOG4108S4C acetyltransferase COP00_12905 ENOG4107XGZ Hydrolase COP00_12910 ENOG4105HKU nucleoside recognition domain-containing protein COP00_12920 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COP00_12925 ENOG410834F Transcriptional regulator COP00_12930 ENOG4105C0R drug resistance transporter emrb qaca subfamily COP00_12935 ENOG41088CQ domain protein COP00_12940 ENOG41086DT Membrane protein of unknown function COP00_12950 ENOG4108PY7 COP00_12965 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COP00_12970 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COP00_12995 ENOG4105CN1 protease COP00_13000 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COP00_13005 ENOG4105Z8B NlpC/P60 family COP00_13010 ENOG4105CRP Part of the ABC transporter FtsEX involved in COP00_13015 ENOG4105CAK Cell division ATP-binding protein ftsE COP00_13035 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COP00_13040 ENOG4105MS2 ribosomal subunit Interface protein COP00_13055 ENOG4105MQ3 flagellar protein FliS COP00_13060 ENOG4107RT6 flagellar hook-associated COP00_13065 ENOG41083S7 flagellar protein FlaG COP00_13070 ENOG4105I03 Flagellin COP00_13075 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) COP00_13080 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) COP00_13085 ENOG4105MKD COP00_13090 ENOG4105DTJ flagellar hook-associated protein COP00_13095 ENOG4105E1Q flagellar hook-associated protein COP00_13110 ENOG4105RU3 COP00_13115 ENOG41081UC Inherit from COG: Competence protein COP00_13135 ENOG4105WH1 Two component transcriptional regulator luxr family COP00_13140 ENOG4105BZU Histidine kinase COP00_13145 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein COP00_13150 ENOG4108KGH TRANSCRIPTIONal COP00_13155 ENOG4105ESV Glycosyl transferase, family 4 COP00_13160 ENOG4107EF8 Glycosyl transferase (Group 1 COP00_13175 ENOG4105QZI O-Antigen Polymerase COP00_13180 ENOG4105C1B dTDP-glucose 4-6-dehydratase COP00_13185 ENOG4105C6Y Udp-glucose 6-dehydrogenase COP00_13190 ENOG4107RA4 Glycosyl transferase (Group 1 COP00_13195 ENOG4105PSV Polysaccharide Biosynthesis Protein COP00_13200 ENOG4105D3Q Sugar transferase COP00_13205 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase COP00_13210 ENOG4105JFG SpoIID LytB domain protein COP00_13220 ENOG4108KGH TRANSCRIPTIONal COP00_13225 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase COP00_13230 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase COP00_13235 ENOG4105EY8 ABC transporter COP00_13260 ENOG4107SJB teichoic acid biosynthesis COP00_13265 ENOG4105C1B dTDP-glucose 4-6-dehydratase COP00_13270 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COP00_13275 ENOG4107SJB teichoic acid biosynthesis COP00_13285 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase COP00_13295 ENOG4107RZX Teichoic acid biosynthesis protein COP00_13305 ENOG4105DG6 mannose-6-phosphate isomerase COP00_13315 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase COP00_13320 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) COP00_13325 ENOG4108UHU Aldolase COP00_13330 ENOG4105D7K pfkb domain protein COP00_13335 ENOG4108M60 Transcriptional regulator COP00_13345 ENOG4105CHR reductase COP00_13350 ENOG4105E2A Dehydrogenase COP00_13355 ENOG4105C54 Major Facilitator superfamily COP00_13360 ENOG4108KGH TRANSCRIPTIONal COP00_13365 ENOG4105J7I hydrolase COP00_13370 ENOG4105K4H Nlp p60 protein COP00_13380 ENOG4105PNM synthesis protein COP00_13390 ENOG4105N98 Capsule biosynthesis protein capB COP00_13395 ENOG4105ETE Transcriptional regulator (LacI family COP00_13400 ENOG4108RVA ribokinase COP00_13405 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) COP00_13410 ENOG4105C2J ABC transporter COP00_13415 ENOG4105CNN ABC, transporter COP00_13420 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator COP00_13425 ENOG4105C5Q Transcriptional regulator COP00_13430 ENOG41089UC methyltransferase, type 11 COP00_13435 ENOG4107FQX Alpha-acetolactate decarboxylase COP00_13460 ENOG4105CAH Chromate COP00_13465 ENOG4105FGV Chromate COP00_13470 ENOG4105C6Y Udp-glucose 6-dehydrogenase COP00_13475 ENOG4108RB3 Capsular polysaccharide biosynthesis protein COP00_13480 ENOG4105HTX biosynthesis protein COP00_13490 ENOG4105KBK Zinc finger, swim domain protein COP00_13495 ENOG4105C0D helicase COP00_13500 ENOG4108YZ9 Urea amidohydrolase subunit gamma COP00_13505 ENOG4105KI2 Urea amidohydrolase subunit beta COP00_13510 ENOG4105CQM Urea amidohydrolase subunit alpha COP00_13515 ENOG410667J hydrolase COP00_13520 ENOG4105E98 transcriptional regulator DeoR family COP00_13525 ENOG4105Z8H single-stranded DNA-binding protein COP00_13545 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) COP00_13550 ENOG4105CGA flagellar basal-body rod protein FlgG COP00_13560 ENOG4105DFF Rod shape-determining protein mreb COP00_13565 ENOG4105MT0 Sporulation transcriptional regulator spoiiid COP00_13575 ENOG4107MII Sugar-specific transcriptional regulator TrmB COP00_13580 ENOG4105CZM Major Facilitator COP00_13585 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase COP00_13590 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase COP00_13600 ENOG4108NA0 Uncharacterized conserved protein (COG2071) COP00_13605 ENOG41080XP Cbs domain COP00_13615 ENOG4105C37 (CBS) domain COP00_13620 ENOG4105BZU Histidine kinase COP00_13645 ENOG4105FRN stage II sporulation protein COP00_13650 ENOG4107TCE N-acetyltransferase COP00_13660 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COP00_13665 ENOG4105C0R drug resistance transporter emrb qaca subfamily COP00_13670 ENOG4105WQT MbtH domain protein COP00_13680 ENOG4105WQI isochorismatase COP00_13685 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase COP00_13690 ENOG4105E4F Isochorismate synthase COP00_13700 ENOG4105NIV Esterase COP00_13720 ENOG410874W AraC family transcriptional regulator COP00_13725 ENOG4106BRK COP00_13730 ENOG4108RYK Nad-dependent epimerase dehydratase COP00_13735 ENOG4108Z40 Transcriptional regulator COP00_13745 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) COP00_13750 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) COP00_13755 ENOG4105FCD Major Facilitator COP00_13765 ENOG4108TF4 von Willebrand factor, type A COP00_13780 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COP00_13790 ENOG4106778 Protein of unknown function (DUF1146) COP00_13795 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COP00_13800 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COP00_13805 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COP00_13810 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COP00_13815 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COP00_13830 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) COP00_13845 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COP00_13850 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COP00_13855 ENOG4108UIC UPF0340 protein COP00_13860 ENOG4108YZG isomerase COP00_13865 ENOG4107WAU Protein tyrosine phosphatase COP00_13870 ENOG410815N Probably functions as a manganese efflux pump (By similarity) COP00_13875 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COP00_13885 ENOG4108ZXQ stage ii sporulation protein r COP00_13900 ENOG4105TRI Hydrolase COP00_13915 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COP00_13920 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COP00_13925 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase COP00_13935 ENOG4107TT2 Auxin Efflux Carrier COP00_13940 ENOG4105C6K Malic enzyme COP00_13945 ENOG4107104 thymidine kinase COP00_13950 ENOG41082DI 50s ribosomal protein l31 COP00_13955 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COP00_13960 ENOG4105CBT Fructose-1,6-bisphosphatase COP00_13965 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COP00_13970 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway COP00_13975 ENOG4105D2N Aldolase COP00_13980 ENOG410812K response regulator receiver protein COP00_13990 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COP00_14005 ENOG4105C1G acyl-Coa dehydrogenase COP00_14010 ENOG4105C1G acyl-Coa dehydrogenase COP00_14015 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase COP00_14025 ENOG4105DF6 Fe-S oxidoreductase COP00_14040 ENOG4105C75 arginyL-tRNA synthetase COP00_14045 ENOG410684U Domain of unknown function (DUF1934) COP00_14050 ENOG4105CYW agmatinase COP00_14055 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) COP00_14060 ENOG4105BZ4 penicillin-binding protein COP00_14070 ENOG4108Z4T Peptidase M50 COP00_14075 ENOG41069HH 4-oxalocrotonate tautomerase COP00_14090 ENOG4105DCI Phosphohydrolase COP00_14100 ENOG4108VCI transcription factor, rsfa family COP00_14110 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) COP00_14120 ENOG4105D2S major facilitator superfamily COP00_14145 ENOG4108FUF Transcriptional regulator, IclR family COP00_14155 ENOG4108IJ2 phosphate acetyltransferase COP00_14160 ENOG4107JTW chlorite dismutase COP00_14185 ENOG4105CJ1 ABC, transporter COP00_14195 ENOG4105WH1 Two component transcriptional regulator luxr family COP00_14215 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COP00_14220 ENOG4108RJ9 Glycosyl transferase, family 2 COP00_14225 ENOG4105DWF phosphomethylpyrimidine kinase COP00_14240 ENOG4105C5Y PTS System COP00_14255 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin COP00_14265 ENOG4105DEN Luciferase family COP00_14270 ENOG4108DBC nitroreductase COP00_14335 ENOG41060D1 Quinol oxidase COP00_14345 ENOG4105BZ9 Cytochrome C oxidase, subunit I COP00_14350 ENOG4105E2S oxidase) subunit II COP00_14355 ENOG4105CMR udp-glucose 4-epimerase COP00_14375 ENOG4108WS4 fmn reductase COP00_14390 ENOG4105CMG Carbohydrate kinase COP00_14395 ENOG4105C93 Xylose Isomerase COP00_14405 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COP00_14410 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase COP00_14415 ENOG4105CMU LysR family (Transcriptional regulator COP00_14435 ENOG41067MG lrgb family COP00_14440 ENOG4105CK7 Sodium proline symporter COP00_14445 ENOG4105DR4 Methyltransferase COP00_14455 ENOG4105C5I Dehydrogenase COP00_14460 ENOG4105X1N Glycosyl transferase family 8 COP00_14470 ENOG4105DJB Major Facilitator Superfamily COP00_14475 ENOG4105CXK mandelate racemase muconate lactonizing COP00_14480 ENOG4108UHU Aldolase COP00_14485 ENOG4105D7K pfkb domain protein COP00_14490 ENOG4105J4Q Transcriptional regulator COP00_14495 ENOG4105IIU Aminopeptidase COP00_14515 ENOG41080V3 Major Facilitator superfamily COP00_14520 ENOG4105D3W isochorismatase COP00_14540 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COP00_14545 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein COP00_14550 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) COP00_14555 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD COP00_14560 ENOG4105CM2 brancheD-chain amino acid aminotransferase COP00_14570 ENOG4105F8D glycoside hydrolase family 4 COP00_14575 ENOG4105VCP PTS System COP00_14580 ENOG4105CK1 PTS System COP00_14585 ENOG4105VZJ PTS System COP00_14590 ENOG4105EMD TRANSCRIPTIONal COP00_14595 ENOG4108VX5 3-methyladenine DNA glycosylase COP00_14600 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase COP00_14605 ENOG4105C5E polysaccharide biosynthesis protein COP00_14625 ENOG4105DXD 2-methylcitrate dehydratase COP00_14630 ENOG4105CR4 methylisocitrate lyase COP00_14635 ENOG4105BZ1 (ABC) transporter COP00_14640 ENOG4107TDE lipolytic protein G-D-S-L family COP00_14665 ENOG4105DA5 (ABC) transporter COP00_14710 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) COP00_14715 ENOG4108J20 pectate lyase COP00_14720 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COP00_14730 ENOG4108JJ8 (ABC) transporter COP00_14735 ENOG4108JJ9 ABC, transporter COP00_14740 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii COP00_14745 ENOG4105C4M (Ubiquinol oxidase) subunit I COP00_14755 ENOG4108QTI )-transporter COP00_14770 ENOG4105DFD Na H antiporter COP00_14775 ENOG4108IJ0 Aspartate ammonia-lyase COP00_14780 ENOG4105HDK L-asparaginase COP00_14785 ENOG4108IMY Transcriptional regulator COP00_14790 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) COP00_14830 ENOG4107BJW polysaccharide deacetylase COP00_14835 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family COP00_14845 ENOG4107QZ7 Cellulose synthase catalytic subunit COP00_14850 ENOG4105D2K citrate carrier protein COP00_14855 ENOG4108QXE glycerophosphoryl diester phosphodiesterase COP00_14860 ENOG4105X3H Excalibur domain protein COP00_14885 ENOG4105E0M Sulfatase COP00_14900 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) COP00_14905 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) COP00_14915 ENOG4105CEU Arginine dihydrolase COP00_14920 ENOG4105DBV ornithine carbamoyltransferase COP00_14930 ENOG4105C5B carbamate kinase COP00_14955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family COP00_14965 ENOG4105CS2 ec 3.2.1.21 COP00_14970 ENOG4105CK1 PTS System COP00_14980 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) COP00_14985 ENOG4105D7K pfkb domain protein COP00_14995 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) COP00_15000 ENOG4105ETE Transcriptional regulator (LacI family COP00_15020 ENOG4105EDW glycosyl transferase, family 39 COP00_15025 ENOG4105CKK Glycosyl transferase, family 2 COP00_15030 ENOG4105CMR udp-glucose 4-epimerase COP00_15045 ENOG4105VZ8 Transcriptional regulator COP00_15055 ENOG4105CH6 catalase COP00_15060 ENOG4105D4T Citrate transporter COP00_15065 ENOG4105CS2 ec 3.2.1.21 COP00_15070 ENOG4105C5Y PTS System COP00_15075 ENOG4105CID antiterminator COP00_15080 ENOG4108W7F transporter, permease COP00_15085 ENOG4108JJB ABC transporter COP00_15095 ENOG4105ETU transcriptional activator (TenA COP00_15110 ENOG4107QP3 malate synthase g COP00_15130 ENOG4105C19 ABC transporter COP00_15135 ENOG4105EWM Histidine kinase COP00_15145 ENOG4105CS2 ec 3.2.1.21 COP00_15150 ENOG4105C5Y PTS System COP00_15160 ENOG4107QHE Choloylglycine hydrolase COP00_15165 ENOG4106Z5D Glycoside Hydrolase Family 43 COP00_15170 ENOG4105C1J atp-dependent rna helicase COP00_15180 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COP00_15185 ENOG4105D9N nucleoside COP00_15190 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COP00_15195 ENOG4107RHR regulatoR COP00_15215 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) COP00_15220 ENOG4107R8N Glycosyl transferase, family 2 COP00_15255 ENOG4105D2N Aldolase COP00_15260 ENOG4107TRN Xylose isomerase domain protein TIM barrel COP00_15265 ENOG4105F0H myo-inositol catabolism protein COP00_15270 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) COP00_15280 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) COP00_15285 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) COP00_15290 ENOG4105D7K pfkb domain protein COP00_15295 ENOG4105DH8 myo-inositol catabolism COP00_15300 ENOG4105C26 Dehydrogenase COP00_15310 ENOG4105CPC Aldo Keto reductase COP00_15320 ENOG4105CXY transporter COP00_15325 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) COP00_15330 ENOG4105C5H ABC transporter COP00_15335 ENOG410667J hydrolase COP00_15345 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) COP00_15355 ENOG4108V5C ABC transporter COP00_15385 ENOG4105H93 Acyltransferase family COP00_15430 ENOG4105EG2 ABC transporter, permease COP00_15440 ENOG4107FKK extracellular solute-binding protein family 1 COP00_15455 ENOG4105CMR udp-glucose 4-epimerase COP00_15465 ENOG4105E2R ROK family COP00_15470 ENOG4105G3Z GntR family transcriptional regulator COP00_15475 ENOG4105CMG Carbohydrate kinase COP00_15490 ENOG4108EKI Dehydrogenase COP00_15500 ENOG4105D3R alkyl hydroperoxide reductase COP00_15505 ENOG4108JU3 Alkyl hydroperoxide reductase COP00_15510 ENOG4105C85 amino acid COP00_15525 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COP00_15535 ENOG4105GR3 Histidine kinase COP00_15540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family COP00_15575 ENOG4105DQ5 transport system permease protein COP00_15580 ENOG4105EHG Permease protein COP00_15585 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COP00_15610 ENOG4108M15 ABC transporter COP00_15615 ENOG4105KCT ABC transporter COP00_15620 ENOG4105BZU Histidine kinase COP00_15670 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COP00_15685 ENOG4105WQG acetyltransferase COP00_15700 ENOG4105C0H protease COP00_15705 ENOG4105Q2H domain protein COP00_15720 ENOG4105BZU Histidine kinase COP00_15725 ENOG4105CK6 Two component transcriptional regulator (Winged helix family COP00_15750 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis COP00_15760 ENOG4105CDU Replicative dna helicase COP00_15775 ENOG4105DJ2 Major Facilitator Superfamily COP00_15780 ENOG4105CE4 GlcNAc 6-P deacetylase COP00_15785 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COP00_15790 ENOG4105FDP GntR family transcriptional regulator COP00_15795 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate COP00_15805 ENOG4105K9Q Binds to the 23S rRNA (By similarity) COP00_15810 ENOG4105BZR domain protein COP00_15815 ENOG4108XMW Membrane COP00_15830 ENOG4105CHH sulfate transporter COP00_15840 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COP00_15845 ENOG4108UUM single-stranded DNA-binding protein COP00_15850 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) COP00_15855 ENOG4105C3G gtp-binding protein COP00_15860 ENOG4105VDK protein, conserved in bacteria COP00_15870 ENOG4108ZDA Sporulation protein YyaC COP00_15875 ENOG4105FA0 parb-like partition protein COP00_15880 ENOG4107QJE Chromosome Partitioning Protein COP00_15885 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COP00_15890 ENOG4108KPJ rna polymerase sigma factor COP00_15895 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) COP00_15905 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COP00_15910 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COP00_15925 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COP00_15935 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COP00_15940 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COP00_15945 ENOG410848D S4 domain protein YaaA COP00_15950 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COP00_15960 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COP00_15965 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COP00_16000 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COP00_16010 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COP00_16015 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COP00_16020 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COP00_16025 ENOG4105BZW Glycerate kinase COP00_16035 ENOG4107VHA regulatoR COP00_16040 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) COP00_16055 ENOG4105ST3 Transcriptional regulator COP00_16060 ENOG4105ZMH deoxynucleoside kinase COP00_16070 ENOG4105VRS hydrolase family 18 COP00_16075 ENOG4105GTG Isochorismatase COP00_16080 ENOG4108Z6B deaminase COP00_16090 ENOG4105C6E dna polymerase iii COP00_16095 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COP00_16100 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COP00_16110 ENOG41067KS pro-sigma K processing COP00_16150 ENOG4105CDW Resistance protein COP00_16155 ENOG4105CXN decarboxylase COP00_16160 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COP00_16165 ENOG4105X0R protein from nitrogen regulatory protein P-II COP00_16170 ENOG4105XVJ Protein of unknown function (DUF327) COP00_16175 ENOG4105FA2 dna polymerase iii COP00_16180 ENOG4105MA4 psp1 domain protein COP00_16185 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) COP00_16190 ENOG41060K3 Methyltransferase COP00_16195 ENOG4105VC4 domain protein COP00_16200 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COP00_16205 ENOG4105KRN Transcriptional regulator, abrb family COP00_16210 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COP00_16215 ENOG4105F8V Hydrolase, tatD family COP00_16220 ENOG41069ER domain protein COP00_16230 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COP00_16235 ENOG4105XFA sporulation peptidase YabG COP00_16240 ENOG4105W42 Veg protein COP00_16245 ENOG4105XEW small acid-soluble spore protein COP00_16250 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COP00_16255 ENOG4105DFT pur operon repressor COP00_16260 ENOG4105KME endoribonuclease L-psp COP00_16265 ENOG4105K4W Could be involved in septation (By similarity) COP00_16270 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COP00_16275 ENOG4105C5T Phosphoribosyl pyrophosphate synthase COP00_16280 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COP00_16295 ENOG4108JA2 transcriptioN-repair coupling factor COP00_16300 ENOG4108M14 stage v sporulation protein t COP00_16310 ENOG4108IY2 MazG family COP00_16315 ENOG41082I2 s4 domain protein COP00_16320 ENOG4105VYY sporulation protein yabp COP00_16335 ENOG41060GV RNA binding s1 domain protein COP00_16365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COP00_16370 ENOG4108UGV hypoxanthine phosphoribosyltransferase COP00_16375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COP00_16385 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COP00_16390 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase COP00_16395 ENOG4105C6T cysteine synthase COP00_16400 ENOG4105CRQ synthase (Component I) COP00_16405 ENOG4105DDQ anthranilate synthase COP00_16410 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 COP00_16415 ENOG4105EEI dihydropteroate synthase COP00_16420 ENOG4105KRF dihydroneopterin aldolase COP00_16425 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COP00_16435 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COP00_16440 ENOG4105CRK lysyL-tRNA synthetase COP00_16525 ENOG4108Z0C Uvrb UvrC protein COP00_16530 ENOG41066A3 ATP guanido phosphotransferase COP00_16540 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) COP00_16545 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) COP00_16550 ENOG4105CTP PilT protein domain protein COP00_16555 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COP00_16560 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COP00_16565 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COP00_16570 ENOG4105D7W serine acetyltransferase COP00_16575 ENOG4105C8N cysteinyl-tRNA synthetase COP00_16585 ENOG4105C2N RNA methyltransferase TrmH family group 3 COP00_16590 ENOG4105M0M Tetracycline resistance protein COP00_16595 ENOG4105QIV RNA polymerase COP00_16605 ENOG410683Z Preprotein translocase SecE subunit COP00_16610 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) COP00_16615 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) COP00_16620 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COP00_16625 ENOG4108VZM 50s ribosomal protein L10 COP00_16630 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COP00_16635 ENOG4107Y49 methyltransferase COP00_16640 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COP00_16645 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COP00_16650 ENOG4105XPM ribosomal protein COP00_16655 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COP00_16660 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COP00_16665 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COP00_16670 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COP00_16675 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) COP00_16680 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COP00_16685 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COP00_16690 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COP00_16695 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COP00_16700 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COP00_16705 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COP00_16710 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COP00_16715 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COP00_16720 ENOG41082SA 50s ribosomal protein l29 COP00_16725 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COP00_16730 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COP00_16735 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COP00_16740 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COP00_16745 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COP00_16750 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COP00_16755 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COP00_16760 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COP00_16765 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COP00_16770 ENOG4105VPB 50S ribosomal protein L30 COP00_16775 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) COP00_16780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COP00_16785 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COP00_16790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) COP00_16800 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COP00_16810 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COP00_16815 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COP00_16820 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COP00_16825 ENOG4108ZT0 50S ribosomal protein l17 COP00_16830 ENOG4108JJB ABC transporter COP00_16835 ENOG4108JJB ABC transporter COP00_16845 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COP00_16850 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COP00_16855 ENOG4108UJD 30S ribosomal protein S9 COP00_16880 ENOG4105D1F ATP-binding protein COP00_16895 ENOG4108NMV polysaccharide deacetylase COP00_16925 ENOG4108A04 Beta-lactamase COP00_16940 ENOG4105EHZ conserved protein UCP016719 COP00_16945 ENOG4105D17 glycoside hydrolase, family 3 domain protein COP00_16965 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate COP00_16970 ENOG4105EWC Purine nucleoside phosphorylase COP00_17005 ENOG4105EMN RNA polymerase sigma factor COP00_17015 ENOG4105C8B TIGR00159 family COP00_17020 ENOG4107U5W ybbr family COP00_17025 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COP00_17035 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COP00_17040 ENOG4108ZMX Domain of unknown function (DU1801) COP00_17045 ENOG4105WAB arsR family transcriptional regulator COP00_17050 ENOG4108RWP Major Facilitator Superfamily protein COP00_17055 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COP00_17070 ENOG4105DVE abc transporter atp-binding protein COP00_17075 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family COP00_17080 ENOG4105D9U N-acetyltransferase COP00_17120 ENOG4105BZ1 (ABC) transporter COP00_17135 ENOG4105CJ1 ABC, transporter COP00_17145 ENOG4107ZXU DSBA oxidoreductase COP00_17170 ENOG41075D4 Aminoglycoside 6-adenylyltransferase COP00_17205 ENOG4106DDH Sporulation-specific SASP protein COP00_17225 ENOG4105C7Z Conserved Protein COP00_17230 ENOG4105C7Z Conserved Protein COP00_17235 ENOG41068WC Domain of unknown function (DUF955) COP00_17240 ENOG4108IMY Transcriptional regulator COP00_17260 ENOG4108RYM conjugative transposon protein COP00_17265 ENOG4106BHR ftsk SpoIIIE family protein COP00_17270 ENOG4106128 DNA-binding helix-turn-helix protein COP00_17310 ENOG4105P1M Domain of unknown function (DUF1874) COP00_17320 ENOG4105K4H Nlp p60 protein COP00_17370 ENOG4105C7Z Conserved Protein COP00_17375 ENOG4105FTQ Dna gyrase COP00_17390 ENOG4105ED2 Beta-lactamase COP00_17395 ENOG4105C7Z Conserved Protein COP00_17400 ENOG4105FTQ Dna gyrase COP00_17410 ENOG4105KVH Transcriptional regulator COP00_17415 ENOG4108WC5 Alpha Beta Hydrolase Fold protein COP00_17425 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase COP00_17450 ENOG4105KRN Transcriptional regulator, abrb family COP00_17495 ENOG4105DY8 decarboxylase COP00_17500 ENOG41062A4 Transcriptional regulator COP00_17515 ENOG4108TVJ Nitroreductase COP00_17520 ENOG4105DRR Transcriptional regulator, GntR family COP00_17540 ENOG4107I77 yiaA/B two helix domain COP00_17570 ENOG410631K Membrane COP00_17575 ENOG4106AXJ AraC family transcriptional regulator COP00_17590 ENOG4107SCQ Iron-containing alcohol dehydrogenase COP00_17600 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid COP00_17615 ENOG410901P UPF0249 protein COP00_17630 ENOG4107TXC Transcriptional regulator COP00_17635 ENOG4105CUB amino acid COP00_17650 ENOG4105MUA Resistance protein COP00_17660 ENOG4105CSV Glutaminase COP00_17675 ENOG4105KNA -acetyltransferase COP00_17680 ENOG4105DGI Alkaline phosphatase COP00_17685 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) COP00_17690 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) COP00_17695 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase COP00_17700 ENOG4105C26 Dehydrogenase COP00_17705 ENOG4105DJB Major Facilitator Superfamily COP00_17710 ENOG4105EQX glucarate dehydratase COP00_17715 ENOG41073TP transcriptional regulator COP00_17720 ENOG4105CTX dehydratase COP00_17730 ENOG4106FGC COP00_17740 ENOG4108R1P COP00_17745 ENOG4106K80 COP00_17755 ENOG41067TZ transcriptional regulator, MarR family COP00_17780 ENOG4107TXC Transcriptional regulator COP00_17795 ENOG4106UX7 integral membrane protein COP00_17805 ENOG41060AI SEC-C motif COP00_17810 ENOG4105DA5 (ABC) transporter COP00_17835 ENOG4107RSM transcriptional regulator COP00_17840 ENOG4105MDS 4-oxalocrotonate tautomerase COP00_17850 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) COP00_17870 ENOG4107RB3 L-asparaginase COP00_17875 ENOG4108W0I acetyltransferase COP00_17885 ENOG4105DPN Oligoendopeptidase f COP00_17890 ENOG4107BMA Transglycosylase associated protein COP00_17900 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) COP00_17905 ENOG4105CQB FAD linked oxidase domain protein COP00_17910 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases COP00_17915 ENOG4105H9W Short-chain dehydrogenase reductase Sdr COP00_17935 ENOG4105KHC sulfurtransferase COP00_17945 ENOG4105DEN Luciferase family COP00_17950 ENOG4105Z8B NlpC/P60 family COP00_17960 ENOG4105CIG ABC transporter COP00_17965 ENOG4108RZE Tetr family transcriptional regulator COP00_17970 ENOG4107A6P COP00_17990 ENOG4108N0M stress protein COP00_17995 ENOG4106FN3 tellurium resistance protein COP00_18000 ENOG4106FN3 tellurium resistance protein COP00_18005 ENOG4107TS3 membrane protein, TerC COP00_18020 ENOG4105DAX Pfam:DUF2983 COP00_18035 ENOG4108TTB tellurium resistance protein COP00_18045 ENOG4108IJ7 Glycine betaine COP00_18050 ENOG4107SQ8 Glycine betaine COP00_18075 ENOG4105C0R drug resistance transporter emrb qaca subfamily COP00_18105 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COP00_18110 ENOG410756H nucleotidyltransferase COP00_18120 ENOG4105C26 Dehydrogenase COP00_18125 ENOG4105CK7 Sodium proline symporter COP00_18130 ENOG4107YHD transcriptional regulator COP00_18140 ENOG4108PJD permease COP00_18150 ENOG4105I82 acetyl xylan esterase COP00_18175 ENOG4105E5Q amino acid AbC transporter COP00_18180 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein COP00_18195 ENOG4108HUF Transporter COP00_18200 ENOG4105DQ5 transport system permease protein COP00_18205 ENOG4108U1V ABC transporter, permease COP00_18210 ENOG4105E0A ABC, transporter COP00_18215 ENOG4108VEN abc transporter atp-binding protein COP00_18220 ENOG4105CS2 ec 3.2.1.21 COP00_18260 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COP00_18265 ENOG4105F38 ABC transporter, permease COP00_18310 ENOG4108SA1 esterase COP00_18315 ENOG41086D8 Transcriptional regulator COP00_18345 ENOG4105CDA abc transporter atp-binding protein COP00_18350 ENOG4105DRP amino acid AbC transporter COP00_18360 ENOG4108JUB Transcriptional regulator COP00_18365 ENOG4105C8Y Acetylornithine aminotransferase COP00_18375 ENOG41066UZ arginase EC 3.5.3.1 COP00_18385 ENOG4108U05 Transcriptional regulator COP00_18390 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 COP00_18400 ENOG4106P55 Transcriptional regulator COP00_18405 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase COP00_18410 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) COP00_18415 ENOG41069ZX COP00_18420 ENOG41069ZX COP00_18470 ENOG4105C2F Histidine kinase COP00_18480 ENOG4105DFW ABC transporter COP00_18490 ENOG4108HWW ABC transporter COP00_18495 ENOG4105DCM major facilitator superfamily COP00_18500 ENOG410645S MarR family Transcriptional regulator COP00_18505 ENOG4105C4C beta-galactosidase COP00_18510 ENOG4107T32 3-phytase (EC 3.1.3.8) COP00_18520 ENOG4105DUX Transporter COP00_18535 ENOG4105E1K spore germination protein COP00_18550 ENOG4107TXC Transcriptional regulator COP00_18560 ENOG4107WD8 ABC transporter, permease COP00_18565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family COP00_18575 ENOG4105EC8 Methyl-accepting chemotaxis COP00_18580 ENOG4105CFH Aspartokinase COP00_18585 ENOG4105DHS permease protein COP00_18590 ENOG4105CM4 permease protein COP00_18595 ENOG4108IPW abc transporter atp-binding protein COP00_18610 ENOG4105R8C Transcriptional regulator COP00_18620 ENOG4108DBC nitroreductase COP00_18625 ENOG41067V3 Antibiotic biosynthesis monooxygenase COP00_18630 ENOG4105YVS arsR family transcriptional regulator COP00_18640 ENOG4108JPW Aminotransferase COP00_18645 ENOG4107QTZ amino acid COP00_18650 ENOG4105C26 Dehydrogenase COP00_18655 ENOG4105EMU Dehydrogenase COP00_18660 ENOG4105KTB nuclear export factor GLE1 COP00_18665 ENOG4108T5E Copper resistance protein COP00_18670 ENOG4108ZYE Transcriptional regulator COP00_18680 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) COP00_18690 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit COP00_18695 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COP00_18700 ENOG4105VUF Transcriptional regulator COP00_18730 ENOG4105E7W lamb ycsf family protein COP00_18735 ENOG4105C5A transporter COP00_18740 ENOG4105CFM UPF0317 protein COP00_18745 ENOG4105P4J Allophanate hydrolase, subunit 1 COP00_18755 ENOG4107258 Transcriptional regulator COP00_18760 ENOG4105XJB lipolytic protein G-D-S-L family COP00_18775 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase COP00_18780 ENOG4105ETD TRANSCRIPTIONal COP00_18785 ENOG4105CYX Short-chain dehydrogenase reductase Sdr COP00_18795 ENOG410606W general stress protein COP00_18805 ENOG4108RCF TRANSCRIPTIONal COP00_18810 ENOG4105VCH membrane COP00_18825 ENOG4105C9U ATP-dependent DNA helicase RecQ COP00_18855 ENOG4105C0X amino acid COP00_18870 ENOG4105H9W Short-chain dehydrogenase reductase Sdr COP00_18885 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) COP00_18890 ENOG4107BMA Transglycosylase associated protein COP00_18900 ENOG41087PP glycosyltransferase MGT family COP00_18905 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) COP00_18910 ENOG4105EU9 COP00_18925 ENOG41082W1 Cupin 2, conserved barrel domain protein COP00_18935 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit COP00_18940 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism COP00_18945 ENOG4108MRH transcriptional regulatory protein COP00_18950 ENOG4107QJT sodium dicarboxylate symporter COP00_18955 ENOG4106F5Q Membrane COP00_18965 ENOG4105CJ1 ABC, transporter COP00_18995 ENOG4105SZ6 Thioredoxin COP00_19000 ENOG4105CPF Cell wall formation (By similarity) COP00_19005 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COP00_19020 ENOG4105C1J atp-dependent rna helicase COP00_19025 ENOG410905X membrane-flanked domain protein COP00_19030 ENOG4105CKV Membrane COP00_19040 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein COP00_19045 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COP00_19055 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) COP00_19060 ENOG4107MMM Anti-sigma-factor antagonist COP00_19065 ENOG4105FUA antagonist COP00_19075 ENOG4107SGM protein serine threonine phosphatase COP00_19095 ENOG41064BQ Phosphatase COP00_19170 ENOG4107T94 Endo-14-beta-xylanase COP00_19205 ENOG41082YX Transcriptional regulator, arsr family COP00_19215 ENOG4105CZ9 Domain of unknown function (DU1801) COP00_19225 ENOG4105KVH Transcriptional regulator COP00_19230 ENOG4108UZ3 Transporter COP00_19235 ENOG4108MCI Transcriptional regulator, ARAC family COP00_19245 ENOG4105EQ0 Major Facilitator superfamily COP00_19250 ENOG4108JGH Tetr family transcriptional regulator COP00_19255 ENOG4108UW5 maltose o-acetyltransferase COP00_19275 ENOG4105IRW patatin-like phospholipase family protein COP00_19280 ENOG4105KVH Transcriptional regulator COP00_19285 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein COP00_19290 ENOG4105C85 amino acid COP00_19295 ENOG4107QRS glycosyltransferase group 2 family protein COP00_19305 ENOG4107XCH Cyclase family COP00_19325 ENOG4108TVJ Nitroreductase COP00_19330 ENOG4105FS7 Transcriptional regulator COP00_19335 ENOG4108VQT Alpha beta hydrolase fold protein COP00_19340 ENOG4105X5K response regulator receiver protein COP00_19345 ENOG4105JVQ RNA Polymerase COP00_19350 ENOG4108P49 AntiSigma factor COP00_19355 ENOG4105EXC Acyl-transferase COP00_19365 ENOG4105C2C drug resistance transporter, Bcr CflA COP00_19380 ENOG4105DY9 regulatoR COP00_19390 ENOG4108Z6X (sortase) family COP00_19415 ENOG4107QNK )-transporter COP00_19460 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) COP00_19465 ENOG4105K8N protein family UPF0079, ATPase COP00_19470 ENOG41072GX Peptidase M22 Glycoprotease COP00_19475 ENOG410801F ribosomal-protein-alanine acetyltransferase COP00_19480 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COP00_19485 ENOG4105C5H ABC transporter COP00_19500 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) COP00_19505 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) COP00_19515 ENOG4108TYN CAAX amino terminal protease family protein COP00_19520 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COP00_19525 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COP00_19530 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COP00_19535 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COP00_19550 ENOG4105XB7 anti-repressor protein COP00_19685 ENOG4105CAR Terminase, large subunit COP00_19700 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COP00_19745 ENOG4108FKH Transglycosylase SLT domain COP00_19755 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj COP00_19765 ENOG41068G1 COP00_19850 ENOG4107EV6 Inherit from COG: YD repeat protein COP00_19890 ENOG4105CZ3 stage V sporulation protein ad COP00_19905 ENOG4108QY0 Membrane COP00_19910 ENOG4108RAV Conserved protein COP00_19915 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase COP00_19920 ENOG4105CUB amino acid COP00_19955 ENOG4105K78 MarR family Transcriptional regulator COP00_19960 ENOG4108VHC Short-chain dehydrogenase reductase Sdr COP00_19980 ENOG4108NGU Transcriptional regulator COP00_19985 ENOG4105N14 lysine exporter protein LysE YggA COP00_19990 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COP00_20020 ENOG4108ZJ4 polysaccharide deacetylase COP00_20025 ENOG4105E5K Alpha-amylase COP00_20030 ENOG4105FKQ transcriptional regulator COP00_20035 ENOG4108IUK alpha amylase, catalytic COP00_20040 ENOG4107FKK extracellular solute-binding protein family 1 COP00_20045 ENOG4105D56 permease protein COP00_20050 ENOG4105EG2 ABC transporter, permease COP00_20065 ENOG4105CG3 alpha amylase, catalytic region COP00_20070 ENOG4107URF beta-phospho-glucomutase COP00_20130 ENOG4107STQ Multicopper oxidase COP00_20145 ENOG4105C7R Atpase associated with various cellular activities aaa_3 COP00_20160 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) COP00_20165 ENOG4105C7N Xanthine uracil vitamin C permease COP00_20175 ENOG4108U5N UPF0316 protein COP00_20185 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COP00_20190 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit COP00_20195 ENOG4105C83 adenylosuccinate lyase COP00_20200 ENOG4105C8V SAICAR synthetase COP00_20205 ENOG4105VR9 phosphoribosylformylglycinamidine synthase COP00_20215 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii COP00_20225 ENOG4105CXB phosphoribosylaminoimidazole synthetase COP00_20230 ENOG4108V3E phosphoribosylglycinamide formyltransferase COP00_20235 ENOG4105DC1 bifunctional purine biosynthesis protein purh COP00_20240 ENOG4105C12 Phosphoribosylglycinamide synthetase COP00_20265 ENOG4108R5T secreted protein COP00_20270 ENOG4105KGF protein, YerC YecD COP00_20280 ENOG4105C4R Atp-dependent dna helicase COP00_20285 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COP00_20295 ENOG4105KT7 mgtC SapB transporter COP00_20305 ENOG4105CK7 Sodium proline symporter COP00_20310 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COP00_20315 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COP00_20320 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COP00_20335 ENOG4108IG5 Transcriptional regulator COP00_20345 ENOG4105D9U N-acetyltransferase COP00_20350 ENOG4105DU0 nucleoside hydrolase COP00_20355 ENOG4105CBD Diacylglycerol kinase COP00_20360 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COP00_20385 ENOG4105C5Y PTS System COP00_20390 ENOG4105CS2 ec 3.2.1.21 COP00_20395 ENOG4105CID antiterminator COP00_20405 ENOG410780I phosphoprotein phosphatase activity COP00_20430 ENOG4105CHR reductase COP00_20440 ENOG4108HFV COP00_20455 ENOG4108PCN EamA-like transporter family COP00_20460 ENOG4105CDY transcriptional regulatory protein COP00_20470 ENOG4107QPK )-transporter COP00_20475 ENOG4105C6K Malic enzyme COP00_20480 ENOG4107ZGM malolactic fermentation system COP00_20485 ENOG4105C26 Dehydrogenase COP00_20490 ENOG4105FKZ Methyl-accepting chemotaxis COP00_20500 ENOG4105XEA Tetr family transcriptional regulator COP00_20505 ENOG4105C8P )-transporter COP00_20510 ENOG4105C5H ABC transporter COP00_20515 ENOG4105YVS arsR family transcriptional regulator COP00_20520 ENOG4107XZQ multidrug resistance protein COP00_20525 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) COP00_20530 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase COP00_20545 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) COP00_20550 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COP00_20555 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) COP00_20560 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) COP00_20565 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COP00_20570 ENOG4106A3M Cytochrome p-450 COP00_20575 ENOG4107SWG transcriptional regulator MERR family COP00_20580 ENOG4105DXB Major Facilitator superfamily COP00_20585 ENOG4105C5H ABC transporter COP00_20590 ENOG4105FDU atp-dependent rna helicase COP00_20605 ENOG4107QPK )-transporter COP00_20615 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COP00_20650 ENOG4105VRS hydrolase family 18 COP00_20670 ENOG41082BM Transcriptional regulator, arsr family COP00_20675 ENOG410855V Acylphosphatase COP00_20680 ENOG4108RPX mosc domain containing protein COP00_20695 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) COP00_20715 ENOG4105C5Y PTS System COP00_20720 ENOG4105CG3 alpha amylase, catalytic region COP00_20725 ENOG4107414 GntR family transcriptional regulator COP00_20740 ENOG4108SHN Glycosyl transferase, family 2 COP00_20745 ENOG4107TVC Glycosyl transferase, family 2 COP00_20750 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) COP00_20775 ENOG4107QQG Dehydrogenase COP00_20780 ENOG4105RXJ COP00_20785 ENOG4105KPY Small multidrug resistance protein COP00_20790 ENOG4105KBX Transcriptional regulator, TetR family COP00_20800 ENOG4105KVH Transcriptional regulator COP00_20805 ENOG4108RCM Nitroreductase COP00_20820 ENOG4105CGH 5'-nucleotidase COP00_20835 ENOG4105KJF protein tyrosine phosphatase COP00_20845 ENOG4107U9T Pfam:Ribonuclease_BN COP00_20860 ENOG4105UPD Calcium Proton COP00_20890 ENOG4105DCT glycerol dehydrogenase COP00_20905 ENOG4105D7N magnesium and cobalt transport protein CorA COP00_20915 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COP00_20950 ENOG41079KZ Major Facilitator Superfamily COP00_20970 ENOG4107RUY (E1 component), alpha subunit COP00_20990 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family COP00_20995 ENOG4105KK4 UPF0060 membrane protein COP00_21000 ENOG4105F8D glycoside hydrolase family 4 COP00_21005 ENOG4108Q3X Transcriptional regulator COP00_21010 ENOG4105CI1 PTS System COP00_21020 ENOG4105KVH Transcriptional regulator COP00_21030 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase COP00_21035 ENOG4105E4I Glycoside hydrolase family 28 COP00_21045 ENOG4106HBX Transcriptional Regulator AraC Family COP00_21055 ENOG4105YA8 Transcriptional regulator COP00_21060 ENOG4107Y80 Major Facilitator superfamily COP00_21065 ENOG4105DYS nad(p)h dehydrogenase (quinone) COP00_21085 ENOG4105JAB phenazine biosynthesis protein, phzf family COP00_21090 ENOG4107Y03 Nitroreductase COP00_21115 ENOG410691R Modulates RecA activity (By similarity) COP00_21140 ENOG4107VFR oxidoreductase COP00_21145 ENOG4105CKK Glycosyl transferase, family 2 COP00_21155 ENOG4105EJV Membrane COP00_21160 ENOG41067AE Membrane-bound metal-dependent hydrolase COP00_21165 ENOG4105CEN a g-specific adenine glycosylase COP00_21170 ENOG4106BXE COP00_21175 ENOG4105CAN Short-chain dehydrogenase reductase Sdr COP00_21195 ENOG4105BZ1 (ABC) transporter COP00_21200 ENOG4105C3U ABC transporter COP00_21205 ENOG4108JQ7 (ABC) transporter COP00_21210 ENOG4105DEF Extracellular solute-binding protein, family 5 COP00_21215 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component COP00_21220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component COP00_21225 ENOG4107NBY Membrane COP00_21230 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase COP00_21235 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COP00_21240 ENOG4105G5W regulator Fur family COP00_21245 ENOG4105TUA UPF0295 protein COP00_21350 ENOG4105C22 threonyL-tRNA synthetase COP00_21370 ENOG4105FF2 Type I DHQase COP00_21385 ENOG4105D7T ABC transporter COP00_21390 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein COP00_21395 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component COP00_21400 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) COP00_21405 ENOG4107D63 COP00_21410 ENOG4105VZ8 Transcriptional regulator COP00_21420 ENOG4108JJB ABC transporter COP00_21440 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COP00_21455 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) COP00_21465 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COP00_21485 ENOG4105CYN Serine protein kinase COP00_21490 ENOG4106AKX UPF0229 protein COP00_21495 ENOG4105CW7 secretion protein, HlyD family COP00_21500 ENOG4105C0R drug resistance transporter emrb qaca subfamily COP00_21505 ENOG4105CS1 NAD(P)H quinone oxidoreductase COP00_21520 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family COP00_21525 ENOG4105CZV ABC transporter COP00_21530 ENOG4105CJ1 ABC, transporter COP00_21535 ENOG4108TU7 Inherit from COG: (ABC) transporter COP00_21540 ENOG4105VEQ Cold shock protein COP00_21545 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COP00_21550 ENOG4108UMI ABC transporter, permease COP00_21560 ENOG4107R6U sodium dicarboxylate symporter COP00_21590 ENOG4105BZU Histidine kinase COP00_21605 ENOG4108IJ8 ABC transporter COP00_21610 ENOG4105E90 ABC transporter COP00_21615 ENOG4108HQR Glycine betaine COP00_21620 ENOG4105R40 Glycine betaine carnitine choline COP00_21625 ENOG4108YBP pseudouridine synthase COP00_21635 ENOG41080XP Cbs domain COP00_21640 ENOG4107YBY Hydrolase COP00_21645 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase COP00_21650 ENOG4105C5H ABC transporter COP00_21665 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COP00_21670 ENOG4105CB2 alcohol dehydrogenase COP00_21675 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator COP00_21685 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COP00_21690 ENOG4105C6V Glycerol-3-phosphate dehydrogenase COP00_21740 ENOG4105KPV Transcriptional regulator COP00_21745 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) COP00_21750 ENOG4105ED1 spovr family COP00_21755 ENOG4105G6Z alkaline phosphatase COP00_21775 ENOG4105BZN citrate synthase COP00_21785 ENOG41067TZ transcriptional regulator, MarR family COP00_21790 ENOG4105CUB amino acid COP00_21795 ENOG4105C8J )-transporter COP00_21805 ENOG41086D8 Transcriptional regulator COP00_21810 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family COP00_21825 ENOG4105J37 COP00_21830 ENOG4108AEY RNA polymerase sigma factor COP00_21835 ENOG4105F6E Acyl-transferase COP00_21850 ENOG4105C37 (CBS) domain COP00_21860 ENOG4105C37 (CBS) domain COP00_21880 ENOG4105NX3 Membrane COP00_21895 ENOG4108QXE glycerophosphoryl diester phosphodiesterase COP00_21905 ENOG4105D64 Mechanosensitive ion channel COP00_21910 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COP00_21920 ENOG4105I4A GCN5-related N-acetyltransferase COP00_21925 ENOG4107VMI polysaccharide deacetylase COP00_21930 ENOG4105F0I Aminotransferase COP00_21940 ENOG4108N2V aldose 1-epimerase COP00_21975 ENOG4105BZ1 (ABC) transporter COP00_21980 ENOG4105BZ1 (ABC) transporter COP00_22025 ENOG4106MP8 UPF0754 membrane protein COP00_22030 ENOG4105WZB UPF0342 protein COP00_22040 ENOG4105D4P Coproporphyrinogen iii oxidase COP00_22050 ENOG4107S91 Sodium hydrogen exchanger COP00_22055 ENOG4105NCW Trka-c domain protein COP00_22065 ENOG4105CGU Enoyl-CoA hydratase COP00_22080 ENOG4108IUX (ABC) transporter COP00_22085 ENOG4105RHA ABC transporter, permease COP00_22090 ENOG4107VRP DNA repair exonuclease COP00_22095 ENOG4106D4I domain protein COP00_22100 ENOG4105EQI Metal Dependent Phosphohydrolase COP00_22110 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COP00_22155 ENOG4105NBU tryptophan transport protein COP00_22160 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) COP00_22165 ENOG4105K59 histidine triad (HIT) protein COP00_22200 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation COP00_22205 ENOG4105BZ4 penicillin-binding protein COP00_22210 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) COP00_22215 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) COP00_22220 ENOG4105C1Q protoporphyrinogen oxidase COP00_22230 ENOG4105ECB domain protein COP00_22240 ENOG4105DER m42 family COP00_22250 ENOG4106AXD COP00_22255 ENOG4108RQ5 Beta-lactamase domain-containing protein COP00_22260 ENOG4105DF9 Lipoate-protein, ligase COP00_22265 ENOG4105CEY Amp-dependent synthetase and ligase COP00_22275 ENOG4108JCI Transcriptional regulator COP00_22290 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 COP00_22295 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin COP00_22305 ENOG4108HUF Transporter COP00_22310 ENOG4105DQ5 transport system permease protein COP00_22315 ENOG4108U1V ABC transporter, permease COP00_22320 ENOG4107TB6 phosphoglycerate mutase COP00_22325 ENOG4106YBV Methyl-accepting chemotaxis COP00_22345 ENOG4105XVF Competence transcription factor COP00_22350 ENOG41060YP COP00_22370 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin COP00_22375 ENOG410780I phosphoprotein phosphatase activity COP00_22390 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component COP00_22395 ENOG4105I1K ABC transporter COP00_22405 ENOG4108KK1 membrane protein AbrB duplication COP00_22420 ENOG4105WEF catalase COP00_22425 ENOG4105CEY Amp-dependent synthetase and ligase COP00_22435 ENOG41073R8 VanW family COP00_22440 ENOG4105BZU Histidine kinase COP00_22455 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein COP00_22460 ENOG4105E0C molybdate abc transporter COP00_22470 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COP00_22480 ENOG4105EYH Exonuclease COP00_22515 ENOG410751J COP00_22535 ENOG4105ERH Fumarylacetoacetate hydrolase COP00_22555 ENOG4105CAQ asparagine synthetase COP00_22560 ENOG4105UQX Mate efflux family protein COP00_22565 ENOG4106HBX Transcriptional Regulator AraC Family COP00_22595 ENOG4105E1K spore germination protein COP00_22605 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family COP00_22615 ENOG4105DY8 decarboxylase COP00_22640 ENOG4105MA6 gCN5-related N-acetyltransferase COP00_22655 ENOG4108VPT UPF0234 protein COP00_22660 ENOG4105QNR S1 RNA binding domain protein COP00_22675 ENOG4105EPR degv family COP00_22680 ENOG4107AYK membrAne COP00_22690 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) COP00_22695 ENOG41073B9 COP00_22700 ENOG4108KP7 hydrolase COP00_22705 ENOG4108MXZ Esterase COP00_22710 ENOG4105VG1 fes assembly suf system protein COP00_22720 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase COP00_22725 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COP00_22730 ENOG4105CAS nag kinase COP00_22735 ENOG4105C8Y Acetylornithine aminotransferase COP00_22740 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain COP00_22750 ENOG4105DBV ornithine carbamoyltransferase COP00_22775 ENOG4107RMD Basic membrane lipoprotein COP00_22790 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) COP00_22795 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COP00_22805 ENOG4105C3U ABC transporter COP00_22810 ENOG4108JQ7 (ABC) transporter COP00_22825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component COP00_22835 ENOG4105C31 Tryptophanyl-tRNA synthetase COP00_22845 ENOG4108J59 Extracellular solute-binding protein, family 5 COP00_22850 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component COP00_22855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component COP00_22865 ENOG4108JQ7 (ABC) transporter COP00_22875 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) COP00_22880 ENOG4108ZCF integral membrane protein COP00_22885 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis COP00_22895 ENOG4105DPN Oligoendopeptidase f COP00_22910 ENOG4105T58 Dithiol-disulfide isomerase COP00_22915 ENOG4108Z18 K06886 hemoglobin COP00_22920 ENOG4105E4C Lytic transglycosylase catalytic COP00_22925 ENOG4105MIX Adenylate cyclase COP00_22930 ENOG4106EFP UPF0738 protein COP00_22940 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COP00_22945 ENOG4105EMS pseudouridine synthase COP00_22950 ENOG4107S1Q Phosphatase COP00_22960 ENOG4105ETU transcriptional activator (TenA COP00_22965 ENOG4108VEU Thiamine monophosphate synthase COP00_22985 ENOG4105D06 uba thif-type nad fad binding protein COP00_22990 ENOG4105DWF phosphomethylpyrimidine kinase COP00_22995 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH COP00_23000 ENOG4107A88 COP00_23050 ENOG4105ENA helicase COP00_23060 ENOG4107T5V SNARE associated Golgi COP00_23065 ENOG4105CMR udp-glucose 4-epimerase COP00_23085 ENOG4108ZMI UPF0477 protein COP00_23095 ENOG4105C28 cystathionine COP00_23100 ENOG4105C28 cystathionine COP00_23135 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases COP00_23160 ENOG4105CHR reductase COP00_23165 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily COP00_23185 ENOG4107S9D Alpha beta hydrolase COP00_23205 ENOG4107QTZ amino acid COP00_23210 ENOG4105DUM transcriptional regulator, lysR family COP00_23215 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) COP00_23220 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) COP00_23240 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase COP00_23250 ENOG41069ER domain protein COP00_23270 ENOG4105J7D transcriptional regulator COP00_23420 ENOG4105CAR Terminase, large subunit COP00_23490 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj COP00_23500 ENOG41068G1 COP00_23535 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COP00_23580 ENOG4107EV6 Inherit from COG: YD repeat protein COP00_23595 ENOG4105K7W phage-related replication protein COP00_23600 ENOG410635T phage-like element pbsx protein COP00_23650 ENOG4107VXM glycerophosphoryl diester phosphodiesterase COP00_23660 ENOG4107XBN GntR Family Transcriptional Regulator COP00_23665 ENOG4105CPQ Dehydrogenase COP00_23670 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) COP00_23675 ENOG4105DMW Dehydrogenase reductase COP00_23690 ENOG4108I5G Major Facilitator superfamily COP00_23705 ENOG4105CJ3 phosphate transporter COP00_23710 ENOG4107GRR phosphate transport regulator COP00_23715 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) COP00_23720 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein COP00_23725 ENOG4108I5D sulfate abc transporter COP00_23730 ENOG4105ECW sulfate abc transporter COP00_23745 ENOG4105C2F Histidine kinase COP00_23750 ENOG4105EQD regulatoR COP00_23765 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component COP00_23770 ENOG4105F5H Glycosyl Hydrolase Family 88 COP00_23775 ENOG41075H3 AraC family transcriptional regulator COP00_23780 ENOG4107TDE lipolytic protein G-D-S-L family COP00_23795 ENOG4105CX8 fg-gap repeat protein COP00_23800 ENOG4105CX8 fg-gap repeat protein COP00_23805 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) COP00_23810 ENOG4107TDE lipolytic protein G-D-S-L family COP00_23820 ENOG4105EKC COP00_23825 ENOG4105E0S extracellular solute-binding protein family 1 COP00_23835 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component COP00_23840 ENOG4107R7I amino acid COP00_23850 ENOG4105C0H protease COP00_23860 ENOG4108ME1 Peptidase M55 D-aminopeptidase COP00_23865 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component COP00_23870 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component COP00_23875 ENOG4105C3U ABC transporter COP00_23885 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A COP00_23890 ENOG4105DTQ mandelate racemase muconate lactonizing COP00_23895 ENOG4107SN7 NLP P60 protein COP00_23900 ENOG4108JQ7 (ABC) transporter COP00_23910 ENOG4107TUM Amidinotransferase COP00_23915 ENOG4108S4H thioesterase Superfamily protein COP00_23920 ENOG4108J20 pectate lyase COP00_23930 ENOG410839T multidrug resistance protein COP00_23935 ENOG41080TC multidrug resistance protein COP00_23940 ENOG4105CIY formyltetrahydrofolate deformylase COP00_23945 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COP00_23950 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COP00_23960 ENOG4105K56 Transcriptional regulator COP00_23965 ENOG4108ZHJ Organic hydroperoxide resistance protein COP00_23975 ENOG4107Y2X deaminase COP00_23995 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COP00_24000 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin COP00_24005 ENOG4105CJW magnesium transporter COP00_24015 ENOG4105V75 Transcriptional regulator COP00_24035 ENOG4105DQE DNA ligase COP00_24040 ENOG4105FDF Could be involved in DNA repair (By similarity) COP00_24050 ENOG4107T5V SNARE associated Golgi COP00_24055 ENOG4107TS3 membrane protein, TerC COP00_24060 ENOG4108WZW RNA polymerase sigma COP00_24070 ENOG410681C small acid-soluble spore protein COP00_24080 ENOG4105D0M Protease HtpX homolog COP00_24090 ENOG4107RVG penicillin-binding protein COP00_24105 ENOG4108TGC Acyltransferase COP00_24110 ENOG4105BZU Histidine kinase COP00_24115 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COP00_24120 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) COP00_24130 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase COP00_24140 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate COP00_24150 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) COP00_24155 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) COP00_24170 ENOG4105BZU Histidine kinase COP00_24175 ENOG41090MY MarR family Transcriptional regulator COP00_24180 ENOG4105ER2 Ompa motb domain protein COP00_24185 ENOG4105E14 MotA TolQ exbB proton channel COP00_24195 ENOG4108K88 Membrane COP00_24200 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) COP00_24205 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase COP00_24210 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) COP00_24215 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) COP00_24275 ENOG4105WXW Antirepressor COP00_24335 ENOG4105C2M dna polymerase I COP00_24345 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COP00_24370 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COP00_24380 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COP00_24390 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COP00_24400 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COP00_24520 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)