locus-tag class description EQZ20_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EQZ20_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EQZ20_00015 ENOG410848D S4 domain protein YaaA EQZ20_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EQZ20_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQZ20_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQZ20_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EQZ20_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) EQZ20_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) EQZ20_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EQZ20_00095 ENOG4105BZW Glycerate kinase EQZ20_00100 ENOG4107QQ0 gntp family EQZ20_00105 ENOG4107VHA regulatoR EQZ20_00120 ENOG4105ZMH deoxynucleoside kinase EQZ20_00130 ENOG4105VRS hydrolase family 18 EQZ20_00135 ENOG4105GTG Isochorismatase EQZ20_00140 ENOG4108Z6B deaminase EQZ20_00150 ENOG4105C6E dna polymerase iii EQZ20_00155 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EQZ20_00160 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EQZ20_00170 ENOG41067KS pro-sigma K processing EQZ20_00210 ENOG4105CDW Resistance protein EQZ20_00215 ENOG4105CXN decarboxylase EQZ20_00220 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EQZ20_00225 ENOG4105X0R protein from nitrogen regulatory protein P-II EQZ20_00230 ENOG4105XVJ Protein of unknown function (DUF327) EQZ20_00235 ENOG4105FA2 dna polymerase iii EQZ20_00240 ENOG4105MA4 psp1 domain protein EQZ20_00245 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) EQZ20_00250 ENOG41060K3 Methyltransferase EQZ20_00255 ENOG4105VC4 domain protein EQZ20_00260 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EQZ20_00265 ENOG4105KRN Transcriptional regulator, abrb family EQZ20_00270 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EQZ20_00275 ENOG4105F8V Hydrolase, tatD family EQZ20_00280 ENOG41069ER domain protein EQZ20_00290 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EQZ20_00300 ENOG4105XFA sporulation peptidase YabG EQZ20_00305 ENOG4105W42 Veg protein EQZ20_00310 ENOG4105XEW small acid-soluble spore protein EQZ20_00315 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EQZ20_00320 ENOG4105DFT pur operon repressor EQZ20_00325 ENOG4105KME endoribonuclease L-psp EQZ20_00330 ENOG4105K4W Could be involved in septation (By similarity) EQZ20_00335 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EQZ20_00340 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EQZ20_00345 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EQZ20_00360 ENOG4108JA2 transcriptioN-repair coupling factor EQZ20_00365 ENOG4108M14 stage v sporulation protein t EQZ20_00375 ENOG4108IY2 MazG family EQZ20_00380 ENOG41082I2 s4 domain protein EQZ20_00385 ENOG4105VYY sporulation protein yabp EQZ20_00400 ENOG41060GV RNA binding s1 domain protein EQZ20_00430 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EQZ20_00435 ENOG4108UGV hypoxanthine phosphoribosyltransferase EQZ20_00440 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EQZ20_00445 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) EQZ20_00450 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EQZ20_00455 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase EQZ20_00460 ENOG4105C6T cysteine synthase EQZ20_00465 ENOG4105CRQ synthase (Component I) EQZ20_00470 ENOG4105DDQ anthranilate synthase EQZ20_00475 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 EQZ20_00480 ENOG4105EEI dihydropteroate synthase EQZ20_00485 ENOG4105KRF dihydroneopterin aldolase EQZ20_00490 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EQZ20_00500 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EQZ20_00505 ENOG4105CRK lysyL-tRNA synthetase EQZ20_00590 ENOG4108Z0C Uvrb UvrC protein EQZ20_00595 ENOG41066A3 ATP guanido phosphotransferase EQZ20_00605 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EQZ20_00610 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) EQZ20_00615 ENOG4105CTP PilT protein domain protein EQZ20_00620 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EQZ20_00625 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EQZ20_00630 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EQZ20_00635 ENOG4105D7W serine acetyltransferase EQZ20_00640 ENOG4105C8N cysteinyl-tRNA synthetase EQZ20_00645 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) EQZ20_00650 ENOG4105C2N RNA methyltransferase TrmH family group 3 EQZ20_00655 ENOG4105M0M Tetracycline resistance protein EQZ20_00660 ENOG4105QIV RNA polymerase EQZ20_00670 ENOG410683Z Preprotein translocase SecE subunit EQZ20_00675 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EQZ20_00680 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EQZ20_00685 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) EQZ20_00690 ENOG4108VZM 50s ribosomal protein L10 EQZ20_00695 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EQZ20_00700 ENOG4107Y49 methyltransferase EQZ20_00705 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQZ20_00710 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQZ20_00715 ENOG4105XPM ribosomal protein EQZ20_00720 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EQZ20_00725 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EQZ20_00730 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EQZ20_00735 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EQZ20_00740 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EQZ20_00745 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EQZ20_00750 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EQZ20_00755 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EQZ20_00760 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EQZ20_00765 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EQZ20_00770 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EQZ20_00775 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EQZ20_00780 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EQZ20_00785 ENOG41082SA 50s ribosomal protein l29 EQZ20_00790 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EQZ20_00795 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EQZ20_00800 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EQZ20_00805 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EQZ20_00810 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EQZ20_00815 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EQZ20_00820 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EQZ20_00825 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EQZ20_00830 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EQZ20_00835 ENOG4105VPB 50S ribosomal protein L30 EQZ20_00840 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EQZ20_00845 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EQZ20_00850 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EQZ20_00855 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EQZ20_00865 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EQZ20_00875 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EQZ20_00880 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EQZ20_00885 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQZ20_00890 ENOG4108ZT0 50S ribosomal protein l17 EQZ20_00895 ENOG4108JJB ABC transporter EQZ20_00900 ENOG4108JJB ABC transporter EQZ20_00905 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EQZ20_00910 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EQZ20_00915 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EQZ20_00920 ENOG4108UJD 30S ribosomal protein S9 EQZ20_00945 ENOG4105D1F ATP-binding protein EQZ20_00960 ENOG4108NMV polysaccharide deacetylase EQZ20_00990 ENOG4108A04 Beta-lactamase EQZ20_01005 ENOG4105EHZ conserved protein UCP016719 EQZ20_01010 ENOG4105D17 glycoside hydrolase, family 3 domain protein EQZ20_01030 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EQZ20_01035 ENOG4105EWC Purine nucleoside phosphorylase EQZ20_01070 ENOG4105EMN RNA polymerase sigma factor EQZ20_01080 ENOG4105C8B TIGR00159 family EQZ20_01085 ENOG4107U5W ybbr family EQZ20_01090 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EQZ20_01095 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EQZ20_01100 ENOG4108ZMX Domain of unknown function (DU1801) EQZ20_01105 ENOG4105WAB arsR family transcriptional regulator EQZ20_01110 ENOG4108RWP Major Facilitator Superfamily protein EQZ20_01130 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EQZ20_01150 ENOG4105BZ1 (ABC) transporter EQZ20_01155 ENOG4107ZXU DSBA oxidoreductase EQZ20_01170 ENOG41075D4 Aminoglycoside 6-adenylyltransferase EQZ20_01195 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EQZ20_01210 ENOG4106DDH Sporulation-specific SASP protein EQZ20_01230 ENOG4105C7Z Conserved Protein EQZ20_01240 ENOG4105N14 lysine exporter protein LysE YggA EQZ20_01245 ENOG4105C7Z Conserved Protein EQZ20_01250 ENOG4105UNS Pfam:DUF419 EQZ20_01255 ENOG4105C7Z Conserved Protein EQZ20_01260 ENOG4105IRW patatin-like phospholipase family protein EQZ20_01270 ENOG4105KVH Transcriptional regulator EQZ20_01275 ENOG4108WC5 Alpha Beta Hydrolase Fold protein EQZ20_01285 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQZ20_01320 ENOG4108VQJ O-methyltransferase EQZ20_01345 ENOG4105DY8 decarboxylase EQZ20_01355 ENOG41062A4 Transcriptional regulator EQZ20_01360 ENOG4105EYF MMPL domain protein EQZ20_01370 ENOG4108TVJ Nitroreductase EQZ20_01375 ENOG4105DRR Transcriptional regulator, GntR family EQZ20_01455 ENOG4106AXJ AraC family transcriptional regulator EQZ20_01470 ENOG4107SCQ Iron-containing alcohol dehydrogenase EQZ20_01480 ENOG4107ZBH radical SAM domain protein EQZ20_01485 ENOG41066N6 Abortive infection protein EQZ20_01490 ENOG4108WUZ (ABC) transporter EQZ20_01515 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid EQZ20_01530 ENOG410901P UPF0249 protein EQZ20_01550 ENOG4105CUB amino acid EQZ20_01560 ENOG4105MUA Resistance protein EQZ20_01570 ENOG4105CSV Glutaminase EQZ20_01585 ENOG4105KNA -acetyltransferase EQZ20_01590 ENOG4105DGI Alkaline phosphatase EQZ20_01595 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EQZ20_01600 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EQZ20_01605 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase EQZ20_01610 ENOG4105C26 Dehydrogenase EQZ20_01615 ENOG4105DJB Major Facilitator Superfamily EQZ20_01620 ENOG4105EQX glucarate dehydratase EQZ20_01625 ENOG41073TP transcriptional regulator EQZ20_01630 ENOG4105CTX dehydratase EQZ20_01640 ENOG4106FGC EQZ20_01650 ENOG4108R1P EQZ20_01655 ENOG4106K80 EQZ20_01665 ENOG41067TZ transcriptional regulator, MarR family EQZ20_01675 ENOG4107QPD alcohol dehydrogenase EQZ20_01685 ENOG4108JPW Aminotransferase EQZ20_01710 ENOG4107TXC Transcriptional regulator EQZ20_01740 ENOG4106UX7 integral membrane protein EQZ20_01745 ENOG41060AI SEC-C motif EQZ20_01750 ENOG4105DA5 (ABC) transporter EQZ20_01775 ENOG4107RSM transcriptional regulator EQZ20_01780 ENOG4105MDS 4-oxalocrotonate tautomerase EQZ20_01790 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EQZ20_01805 ENOG4107RB3 L-asparaginase EQZ20_01815 ENOG4108W0I acetyltransferase EQZ20_01825 ENOG4105DPN Oligoendopeptidase f EQZ20_01830 ENOG4107BMA Transglycosylase associated protein EQZ20_01840 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EQZ20_01845 ENOG4105CQB FAD linked oxidase domain protein EQZ20_01850 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases EQZ20_01855 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQZ20_01875 ENOG4105KHC sulfurtransferase EQZ20_01885 ENOG4105DEN Luciferase family EQZ20_01890 ENOG4105Z8B NlpC/P60 family EQZ20_01900 ENOG4105CIG ABC transporter EQZ20_01905 ENOG4108RZE Tetr family transcriptional regulator EQZ20_01910 ENOG4107A6P EQZ20_01930 ENOG4108N0M stress protein EQZ20_01935 ENOG4106FN3 tellurium resistance protein EQZ20_01940 ENOG4106FN3 tellurium resistance protein EQZ20_01945 ENOG4107TS3 membrane protein, TerC EQZ20_01960 ENOG4105DAX Pfam:DUF2983 EQZ20_01975 ENOG4108TTB tellurium resistance protein EQZ20_01985 ENOG4108IJ7 Glycine betaine EQZ20_01990 ENOG4107SQ8 Glycine betaine EQZ20_02015 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQZ20_02050 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EQZ20_02055 ENOG410756H nucleotidyltransferase EQZ20_02065 ENOG4105C26 Dehydrogenase EQZ20_02070 ENOG4105CK7 Sodium proline symporter EQZ20_02075 ENOG4107YHD transcriptional regulator EQZ20_02085 ENOG4108PJD permease EQZ20_02090 ENOG4105I82 acetyl xylan esterase EQZ20_02115 ENOG4105E5Q amino acid AbC transporter EQZ20_02120 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein EQZ20_02130 ENOG4108HUF Transporter EQZ20_02135 ENOG4105DQ5 transport system permease protein EQZ20_02140 ENOG4108U1V ABC transporter, permease EQZ20_02145 ENOG4105E0A ABC, transporter EQZ20_02150 ENOG4108VEN abc transporter atp-binding protein EQZ20_02155 ENOG4105CS2 ec 3.2.1.21 EQZ20_02200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EQZ20_02205 ENOG4105F38 ABC transporter, permease EQZ20_02215 ENOG4105CEY Amp-dependent synthetase and ligase EQZ20_02235 ENOG4105SX7 Transporter EQZ20_02245 ENOG4105W8Z 4'-phosphopantetheinyl transferase EQZ20_02255 ENOG41086D8 Transcriptional regulator EQZ20_02265 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EQZ20_02285 ENOG4105CDA abc transporter atp-binding protein EQZ20_02290 ENOG4105DRP amino acid AbC transporter EQZ20_02300 ENOG4108JUB Transcriptional regulator EQZ20_02305 ENOG4105C8Y Acetylornithine aminotransferase EQZ20_02310 ENOG4108IQI permease EQZ20_02315 ENOG41066UZ arginase EC 3.5.3.1 EQZ20_02325 ENOG4108U05 Transcriptional regulator EQZ20_02330 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 EQZ20_02340 ENOG4106P55 Transcriptional regulator EQZ20_02345 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase EQZ20_02350 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EQZ20_02355 ENOG41069ZX EQZ20_02360 ENOG41069ZX EQZ20_02405 ENOG4105C2F Histidine kinase EQZ20_02410 ENOG4105WH1 Two component transcriptional regulator luxr family EQZ20_02415 ENOG4105DFW ABC transporter EQZ20_02425 ENOG4108HWW ABC transporter EQZ20_02430 ENOG4105DCM major facilitator superfamily EQZ20_02435 ENOG410645S MarR family Transcriptional regulator EQZ20_02450 ENOG4107T32 3-phytase (EC 3.1.3.8) EQZ20_02460 ENOG4105DUX Transporter EQZ20_02475 ENOG4105E1K spore germination protein EQZ20_02490 ENOG4107TXC Transcriptional regulator EQZ20_02500 ENOG4107WD8 ABC transporter, permease EQZ20_02505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQZ20_02510 ENOG4105BZU Histidine kinase EQZ20_02520 ENOG4105CFH Aspartokinase EQZ20_02525 ENOG4105DHS permease protein EQZ20_02530 ENOG4105CM4 permease protein EQZ20_02535 ENOG4108IPW abc transporter atp-binding protein EQZ20_02550 ENOG4108DBC nitroreductase EQZ20_02555 ENOG41067V3 Antibiotic biosynthesis monooxygenase EQZ20_02560 ENOG4105YVS arsR family transcriptional regulator EQZ20_02570 ENOG4108JPW Aminotransferase EQZ20_02575 ENOG4107QTZ amino acid EQZ20_02580 ENOG4105C26 Dehydrogenase EQZ20_02600 ENOG4105KTB nuclear export factor GLE1 EQZ20_02605 ENOG4108T5E Copper resistance protein EQZ20_02610 ENOG4108ZYE Transcriptional regulator EQZ20_02620 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EQZ20_02625 ENOG4108IFG nitrite reductase, (NAD(P)H) EQZ20_02630 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit EQZ20_02635 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EQZ20_02640 ENOG4105VUF Transcriptional regulator EQZ20_02680 ENOG4105E7W lamb ycsf family protein EQZ20_02685 ENOG4105C5A transporter EQZ20_02690 ENOG4105CFM UPF0317 protein EQZ20_02695 ENOG4105P4J Allophanate hydrolase, subunit 1 EQZ20_02705 ENOG4107258 Transcriptional regulator EQZ20_02710 ENOG4105XJB lipolytic protein G-D-S-L family EQZ20_02725 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase EQZ20_02730 ENOG4105ETD TRANSCRIPTIONal EQZ20_02735 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EQZ20_02745 ENOG410606W general stress protein EQZ20_02755 ENOG4108RCF TRANSCRIPTIONal EQZ20_02760 ENOG4105VCH membrane EQZ20_02775 ENOG4105C9U ATP-dependent DNA helicase RecQ EQZ20_02780 ENOG4105C0X amino acid EQZ20_02795 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQZ20_02810 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EQZ20_02815 ENOG4107BMA Transglycosylase associated protein EQZ20_02820 ENOG4108IJ0 Aspartate ammonia-lyase EQZ20_02830 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) EQZ20_02835 ENOG4105EU9 EQZ20_02870 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EQZ20_02875 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EQZ20_02880 ENOG4108MRH transcriptional regulatory protein EQZ20_02890 ENOG4106F5Q Membrane EQZ20_02895 ENOG4105CK2 sodium dicarboxylate symporter EQZ20_02900 ENOG4105CJ1 ABC, transporter EQZ20_02915 ENOG4105FDT acyl-CoA dehydrogenase EQZ20_02930 ENOG4105SZ6 Thioredoxin EQZ20_02935 ENOG4105CPF Cell wall formation (By similarity) EQZ20_02940 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EQZ20_02950 ENOG4105C1J atp-dependent rna helicase EQZ20_02955 ENOG410905X membrane-flanked domain protein EQZ20_02970 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein EQZ20_02985 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EQZ20_02990 ENOG4107MMM Anti-sigma-factor antagonist EQZ20_02995 ENOG4105FUA antagonist EQZ20_03000 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase EQZ20_03005 ENOG4107SGM protein serine threonine phosphatase EQZ20_03025 ENOG41064BQ Phosphatase EQZ20_03100 ENOG41082YX Transcriptional regulator, arsr family EQZ20_03110 ENOG4105CZ9 Domain of unknown function (DU1801) EQZ20_03115 ENOG4105D3P Mannan endo-1,4-beta-mannosidase EQZ20_03125 ENOG4108UZ3 Transporter EQZ20_03130 ENOG4108MCI Transcriptional regulator, ARAC family EQZ20_03145 ENOG4108JGH Tetr family transcriptional regulator EQZ20_03150 ENOG4108UW5 maltose o-acetyltransferase EQZ20_03160 ENOG41090E6 transcriptional regulator MERR family EQZ20_03170 ENOG4105IRW patatin-like phospholipase family protein EQZ20_03175 ENOG4105KVH Transcriptional regulator EQZ20_03180 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EQZ20_03190 ENOG4105C85 amino acid EQZ20_03210 ENOG4107XCH Cyclase family EQZ20_03225 ENOG4105CHR reductase EQZ20_03235 ENOG4108TVJ Nitroreductase EQZ20_03240 ENOG4105FS7 Transcriptional regulator EQZ20_03245 ENOG4108VQT Alpha beta hydrolase fold protein EQZ20_03250 ENOG4105X5K response regulator receiver protein EQZ20_03255 ENOG4105JVQ RNA Polymerase EQZ20_03260 ENOG4108P49 AntiSigma factor EQZ20_03265 ENOG4105EXC Acyl-transferase EQZ20_03275 ENOG4105C2C drug resistance transporter, Bcr CflA EQZ20_03310 ENOG4108MRH transcriptional regulatory protein EQZ20_03320 ENOG4107QNK )-transporter EQZ20_03325 ENOG4105C54 Major Facilitator superfamily EQZ20_03365 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EQZ20_03370 ENOG4105K8N protein family UPF0079, ATPase EQZ20_03375 ENOG41072GX Peptidase M22 Glycoprotease EQZ20_03380 ENOG410801F ribosomal-protein-alanine acetyltransferase EQZ20_03385 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EQZ20_03390 ENOG4105C5H ABC transporter EQZ20_03400 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) EQZ20_03405 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EQZ20_03410 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EQZ20_03420 ENOG4108TYN CAAX amino terminal protease family protein EQZ20_03425 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EQZ20_03430 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EQZ20_03435 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQZ20_03440 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EQZ20_03455 ENOG4105XB7 anti-repressor protein EQZ20_03570 ENOG4105CAR Terminase, large subunit EQZ20_03585 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQZ20_03630 ENOG4108FKH Transglycosylase SLT domain EQZ20_03640 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EQZ20_03650 ENOG41068G1 EQZ20_03710 ENOG4107EV6 Inherit from COG: YD repeat protein EQZ20_03725 ENOG41090VF Stage v sporulation protein ac EQZ20_03730 ENOG4105CZ3 stage V sporulation protein ad EQZ20_03745 ENOG4108QY0 Membrane EQZ20_03750 ENOG4108RAV Conserved protein EQZ20_03755 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase EQZ20_03760 ENOG4105CUB amino acid EQZ20_03785 ENOG4108X07 Tetr family transcriptional regulator EQZ20_03790 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EQZ20_03795 ENOG4105K78 MarR family Transcriptional regulator EQZ20_03800 ENOG4108VHC Short-chain dehydrogenase reductase Sdr EQZ20_03805 ENOG4105EBR Carboxylesterase EQZ20_03820 ENOG4108NGU Transcriptional regulator EQZ20_03825 ENOG4105N14 lysine exporter protein LysE YggA EQZ20_03835 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EQZ20_03865 ENOG4108ZJ4 polysaccharide deacetylase EQZ20_03870 ENOG4105E5K Alpha-amylase EQZ20_03875 ENOG4105FKQ transcriptional regulator EQZ20_03880 ENOG4108IUK alpha amylase, catalytic EQZ20_03885 ENOG4107FKK extracellular solute-binding protein family 1 EQZ20_03890 ENOG4105D56 permease protein EQZ20_03895 ENOG4105EG2 ABC transporter, permease EQZ20_03910 ENOG4105CG3 alpha amylase, catalytic region EQZ20_03915 ENOG4107URF beta-phospho-glucomutase EQZ20_03960 ENOG41086D8 Transcriptional regulator EQZ20_03965 ENOG4107STQ Multicopper oxidase EQZ20_03980 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EQZ20_03995 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EQZ20_04000 ENOG4105C7N Xanthine uracil vitamin C permease EQZ20_04010 ENOG4108U5N UPF0316 protein EQZ20_04020 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EQZ20_04025 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EQZ20_04030 ENOG4105C83 adenylosuccinate lyase EQZ20_04035 ENOG4105C8V SAICAR synthetase EQZ20_04040 ENOG4105VR9 phosphoribosylformylglycinamidine synthase EQZ20_04050 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EQZ20_04060 ENOG4105CXB phosphoribosylaminoimidazole synthetase EQZ20_04065 ENOG4108V3E phosphoribosylglycinamide formyltransferase EQZ20_04070 ENOG4105DC1 bifunctional purine biosynthesis protein purh EQZ20_04075 ENOG4105C12 Phosphoribosylglycinamide synthetase EQZ20_04085 ENOG4106A3M Cytochrome p-450 EQZ20_04100 ENOG4108R5T secreted protein EQZ20_04105 ENOG4105KGF protein, YerC YecD EQZ20_04115 ENOG4105C4R Atp-dependent dna helicase EQZ20_04120 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EQZ20_04130 ENOG4105KT7 mgtC SapB transporter EQZ20_04140 ENOG4105CK7 Sodium proline symporter EQZ20_04145 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EQZ20_04150 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EQZ20_04155 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EQZ20_04170 ENOG4108IG5 Transcriptional regulator EQZ20_04180 ENOG4105D9U N-acetyltransferase EQZ20_04185 ENOG4105DU0 nucleoside hydrolase EQZ20_04190 ENOG4105CBD Diacylglycerol kinase EQZ20_04195 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EQZ20_04215 ENOG4105DZR Type I site-specific deoxyribonuclease EQZ20_04220 ENOG410780I phosphoprotein phosphatase activity EQZ20_04235 ENOG4108PCN EamA-like transporter family EQZ20_04240 ENOG4105CDY transcriptional regulatory protein EQZ20_04265 ENOG4107QPK )-transporter EQZ20_04270 ENOG4105C6K Malic enzyme EQZ20_04275 ENOG4107ZGM malolactic fermentation system EQZ20_04280 ENOG4105C26 Dehydrogenase EQZ20_04285 ENOG4105FKZ Methyl-accepting chemotaxis EQZ20_04295 ENOG4105XEA Tetr family transcriptional regulator EQZ20_04300 ENOG4105C8P )-transporter EQZ20_04305 ENOG4105C5H ABC transporter EQZ20_04310 ENOG4105YVS arsR family transcriptional regulator EQZ20_04315 ENOG4107XZQ multidrug resistance protein EQZ20_04320 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) EQZ20_04325 ENOG4105CKI cobalamin synthesis protein EQZ20_04330 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) EQZ20_04335 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EQZ20_04340 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EQZ20_04345 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EQZ20_04350 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EQZ20_04355 ENOG4106A3M Cytochrome p-450 EQZ20_04360 ENOG4107SWG transcriptional regulator MERR family EQZ20_04365 ENOG4105DXB Major Facilitator superfamily EQZ20_04370 ENOG4105C5H ABC transporter EQZ20_04375 ENOG4105FDU atp-dependent rna helicase EQZ20_04390 ENOG4107QPK )-transporter EQZ20_04400 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EQZ20_04450 ENOG41082BM Transcriptional regulator, arsr family EQZ20_04455 ENOG410855V Acylphosphatase EQZ20_04460 ENOG4108RPX mosc domain containing protein EQZ20_04470 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) EQZ20_04485 ENOG4105C5Y PTS System EQZ20_04490 ENOG4105CG3 alpha amylase, catalytic region EQZ20_04495 ENOG4107414 GntR family transcriptional regulator EQZ20_04525 ENOG4108SHN Glycosyl transferase, family 2 EQZ20_04530 ENOG4107TVC Glycosyl transferase, family 2 EQZ20_04535 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) EQZ20_04555 ENOG4107QQG Dehydrogenase EQZ20_04560 ENOG4105RXJ EQZ20_04565 ENOG4105KPY Small multidrug resistance protein EQZ20_04570 ENOG4105KBX Transcriptional regulator, TetR family EQZ20_04580 ENOG4105KVH Transcriptional regulator EQZ20_04585 ENOG4108RCM Nitroreductase EQZ20_04595 ENOG4105CGH 5'-nucleotidase EQZ20_04600 ENOG4107RKG DJ-1/PfpI family EQZ20_04610 ENOG4105KJF protein tyrosine phosphatase EQZ20_04620 ENOG4107U9T Pfam:Ribonuclease_BN EQZ20_04625 ENOG4108ISG Major Facilitator EQZ20_04635 ENOG4105UPD Calcium Proton EQZ20_04660 ENOG4105DCT glycerol dehydrogenase EQZ20_04675 ENOG4105D7N magnesium and cobalt transport protein CorA EQZ20_04685 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EQZ20_04720 ENOG41079KZ Major Facilitator Superfamily EQZ20_04740 ENOG4107RUY (E1 component), alpha subunit EQZ20_04750 ENOG4107QKR Dehydrogenase EQZ20_04760 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EQZ20_04765 ENOG4105KK4 UPF0060 membrane protein EQZ20_04770 ENOG4105F8D glycoside hydrolase family 4 EQZ20_04775 ENOG4108Q3X Transcriptional regulator EQZ20_04780 ENOG4105CI1 PTS System EQZ20_04790 ENOG4105KVH Transcriptional regulator EQZ20_04800 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EQZ20_04805 ENOG4105E4I Glycoside hydrolase family 28 EQZ20_04815 ENOG4106HBX Transcriptional Regulator AraC Family EQZ20_04825 ENOG4105YA8 Transcriptional regulator EQZ20_04830 ENOG4107Y80 Major Facilitator superfamily EQZ20_04835 ENOG4105DYS nad(p)h dehydrogenase (quinone) EQZ20_04855 ENOG4105JAB phenazine biosynthesis protein, phzf family EQZ20_04860 ENOG4107Y03 Nitroreductase EQZ20_04880 ENOG410691R Modulates RecA activity (By similarity) EQZ20_04905 ENOG4107VFR oxidoreductase EQZ20_04910 ENOG4105CKK Glycosyl transferase, family 2 EQZ20_04920 ENOG4105EJV Membrane EQZ20_04925 ENOG41067AE Membrane-bound metal-dependent hydrolase EQZ20_04930 ENOG4105CEN a g-specific adenine glycosylase EQZ20_04935 ENOG4106BXE EQZ20_04940 ENOG4105CAN Short-chain dehydrogenase reductase Sdr EQZ20_04960 ENOG4105BZ1 (ABC) transporter EQZ20_04970 ENOG4105C3U ABC transporter EQZ20_04975 ENOG4108JQ7 (ABC) transporter EQZ20_04980 ENOG4105DEF Extracellular solute-binding protein, family 5 EQZ20_04985 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQZ20_04990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQZ20_04995 ENOG4107NBY Membrane EQZ20_05000 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EQZ20_05005 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQZ20_05010 ENOG4105G5W regulator Fur family EQZ20_05015 ENOG4105TUA UPF0295 protein EQZ20_05140 ENOG4105FF2 Type I DHQase EQZ20_05145 ENOG4108N23 SpoOM-related protein EQZ20_05150 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EQZ20_05155 ENOG4105D7T ABC transporter EQZ20_05160 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein EQZ20_05165 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EQZ20_05170 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EQZ20_05175 ENOG4107D63 EQZ20_05180 ENOG4105VZ8 Transcriptional regulator EQZ20_05190 ENOG4108JJB ABC transporter EQZ20_05210 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EQZ20_05225 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EQZ20_05235 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EQZ20_05255 ENOG4105CYN Serine protein kinase EQZ20_05260 ENOG4106AKX UPF0229 protein EQZ20_05265 ENOG4105CW7 secretion protein, HlyD family EQZ20_05270 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQZ20_05275 ENOG4105CS1 NAD(P)H quinone oxidoreductase EQZ20_05290 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family EQZ20_05295 ENOG4105CZV ABC transporter EQZ20_05300 ENOG4105CJ1 ABC, transporter EQZ20_05305 ENOG4108TU7 Inherit from COG: (ABC) transporter EQZ20_05310 ENOG4105VEQ Cold shock protein EQZ20_05315 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EQZ20_05320 ENOG4108UMI ABC transporter, permease EQZ20_05330 ENOG4107R6U sodium dicarboxylate symporter EQZ20_05365 ENOG4105BZU Histidine kinase EQZ20_05380 ENOG4108IJ8 ABC transporter EQZ20_05385 ENOG4105E90 ABC transporter EQZ20_05390 ENOG4108HQR Glycine betaine EQZ20_05395 ENOG4105R40 Glycine betaine carnitine choline EQZ20_05400 ENOG4108YBP pseudouridine synthase EQZ20_05410 ENOG41080XP Cbs domain EQZ20_05415 ENOG4107YBY Hydrolase EQZ20_05420 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EQZ20_05425 ENOG4105C5H ABC transporter EQZ20_05440 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EQZ20_05445 ENOG4105CB2 alcohol dehydrogenase EQZ20_05450 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EQZ20_05460 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EQZ20_05465 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EQZ20_05485 ENOG4105BZU Histidine kinase EQZ20_05490 ENOG4105WH1 Two component transcriptional regulator luxr family EQZ20_05510 ENOG4105KPV Transcriptional regulator EQZ20_05515 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EQZ20_05520 ENOG4105ED1 spovr family EQZ20_05525 ENOG4105G6Z alkaline phosphatase EQZ20_05545 ENOG4105BZN citrate synthase EQZ20_05550 ENOG41067TZ transcriptional regulator, MarR family EQZ20_05555 ENOG4105CUB amino acid EQZ20_05560 ENOG4105C8J )-transporter EQZ20_05570 ENOG41086D8 Transcriptional regulator EQZ20_05575 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EQZ20_05590 ENOG4105J37 EQZ20_05595 ENOG4108AEY RNA polymerase sigma factor EQZ20_05600 ENOG4105F6E Acyl-transferase EQZ20_05615 ENOG4105C37 (CBS) domain EQZ20_05625 ENOG4105C37 (CBS) domain EQZ20_05645 ENOG4105NX3 Membrane EQZ20_05660 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EQZ20_05670 ENOG4105D64 Mechanosensitive ion channel EQZ20_05675 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EQZ20_05685 ENOG4105I4A GCN5-related N-acetyltransferase EQZ20_05690 ENOG4107VMI polysaccharide deacetylase EQZ20_05695 ENOG4105F0I Aminotransferase EQZ20_05705 ENOG4108N2V aldose 1-epimerase EQZ20_05740 ENOG4105BZ1 (ABC) transporter EQZ20_05745 ENOG4105BZ1 (ABC) transporter EQZ20_05780 ENOG410839P EQZ20_05790 ENOG4106MP8 UPF0754 membrane protein EQZ20_05795 ENOG4105WZB UPF0342 protein EQZ20_05805 ENOG4105D4P Coproporphyrinogen iii oxidase EQZ20_05820 ENOG4107S91 Sodium hydrogen exchanger EQZ20_05825 ENOG4105NCW Trka-c domain protein EQZ20_05835 ENOG4105CGU Enoyl-CoA hydratase EQZ20_05850 ENOG4108IUX (ABC) transporter EQZ20_05855 ENOG4105RHA ABC transporter, permease EQZ20_05860 ENOG4107VRP DNA repair exonuclease EQZ20_05865 ENOG4106D4I domain protein EQZ20_05870 ENOG4105EQI Metal Dependent Phosphohydrolase EQZ20_05880 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EQZ20_05930 ENOG4105NBU tryptophan transport protein EQZ20_05935 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EQZ20_05940 ENOG4105K59 histidine triad (HIT) protein EQZ20_05980 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation EQZ20_05985 ENOG4105BZ4 penicillin-binding protein EQZ20_05990 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EQZ20_05995 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EQZ20_06000 ENOG4105C1Q protoporphyrinogen oxidase EQZ20_06015 ENOG4105ECB domain protein EQZ20_06025 ENOG4105DER m42 family EQZ20_06035 ENOG4106AXD EQZ20_06040 ENOG4108RQ5 Beta-lactamase domain-containing protein EQZ20_06045 ENOG4105DF9 Lipoate-protein, ligase EQZ20_06055 ENOG4105CEY Amp-dependent synthetase and ligase EQZ20_06065 ENOG4108JCI Transcriptional regulator EQZ20_06080 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 EQZ20_06085 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQZ20_06090 ENOG4108HUF Transporter EQZ20_06095 ENOG4105DQ5 transport system permease protein EQZ20_06100 ENOG4108U1V ABC transporter, permease EQZ20_06105 ENOG4107TB6 phosphoglycerate mutase EQZ20_06110 ENOG4106YBV Methyl-accepting chemotaxis EQZ20_06135 ENOG4105XVF Competence transcription factor EQZ20_06140 ENOG41060YP EQZ20_06155 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin EQZ20_06160 ENOG410780I phosphoprotein phosphatase activity EQZ20_06175 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component EQZ20_06180 ENOG4105I1K ABC transporter EQZ20_06190 ENOG4108KK1 membrane protein AbrB duplication EQZ20_06205 ENOG4105WEF catalase EQZ20_06210 ENOG4105CEY Amp-dependent synthetase and ligase EQZ20_06220 ENOG41073R8 VanW family EQZ20_06225 ENOG4105BZU Histidine kinase EQZ20_06230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQZ20_06240 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EQZ20_06245 ENOG4105E0C molybdate abc transporter EQZ20_06255 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EQZ20_06265 ENOG4105EYH Exonuclease EQZ20_06300 ENOG410751J EQZ20_06320 ENOG4105ERH Fumarylacetoacetate hydrolase EQZ20_06340 ENOG4105CAQ asparagine synthetase EQZ20_06345 ENOG4105UQX Mate efflux family protein EQZ20_06350 ENOG4106HBX Transcriptional Regulator AraC Family EQZ20_06360 ENOG4105ETE Transcriptional regulator (LacI family EQZ20_06365 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EQZ20_06370 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EQZ20_06390 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EQZ20_06395 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EQZ20_06405 ENOG4105DY8 decarboxylase EQZ20_06430 ENOG4105MA6 gCN5-related N-acetyltransferase EQZ20_06445 ENOG4108VPT UPF0234 protein EQZ20_06450 ENOG4105QNR S1 RNA binding domain protein EQZ20_06465 ENOG4105EPR degv family EQZ20_06470 ENOG4107AYK membrAne EQZ20_06480 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) EQZ20_06485 ENOG41073B9 EQZ20_06490 ENOG4108KP7 hydrolase EQZ20_06495 ENOG4108MXZ Esterase EQZ20_06500 ENOG4105VG1 fes assembly suf system protein EQZ20_06510 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EQZ20_06515 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EQZ20_06520 ENOG4105CAS nag kinase EQZ20_06525 ENOG4105C8Y Acetylornithine aminotransferase EQZ20_06530 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EQZ20_06540 ENOG4105DBV ornithine carbamoyltransferase EQZ20_06565 ENOG4107RMD Basic membrane lipoprotein EQZ20_06580 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EQZ20_06585 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EQZ20_06595 ENOG4105C3U ABC transporter EQZ20_06600 ENOG4108JQ7 (ABC) transporter EQZ20_06615 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQZ20_06625 ENOG4105C31 Tryptophanyl-tRNA synthetase EQZ20_06630 ENOG4108J59 Extracellular solute-binding protein, family 5 EQZ20_06635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQZ20_06640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQZ20_06650 ENOG4108JQ7 (ABC) transporter EQZ20_06660 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) EQZ20_06665 ENOG4108ZCF integral membrane protein EQZ20_06675 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis EQZ20_06685 ENOG4105DPN Oligoendopeptidase f EQZ20_06695 ENOG4105T58 Dithiol-disulfide isomerase EQZ20_06700 ENOG4108Z18 K06886 hemoglobin EQZ20_06705 ENOG4105E4C Lytic transglycosylase catalytic EQZ20_06710 ENOG4105MIX Adenylate cyclase EQZ20_06715 ENOG4106EFP UPF0738 protein EQZ20_06725 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EQZ20_06730 ENOG4105EMS pseudouridine synthase EQZ20_06735 ENOG4107S1Q Phosphatase EQZ20_06745 ENOG4105ETU transcriptional activator (TenA EQZ20_06750 ENOG4108VEU Thiamine monophosphate synthase EQZ20_06765 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EQZ20_06770 ENOG4105D06 uba thif-type nad fad binding protein EQZ20_06775 ENOG4105DWF phosphomethylpyrimidine kinase EQZ20_06780 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EQZ20_06785 ENOG4107A88 EQZ20_06835 ENOG4105ENA helicase EQZ20_06845 ENOG4107T5V SNARE associated Golgi EQZ20_06850 ENOG4105CMR udp-glucose 4-epimerase EQZ20_06855 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EQZ20_06870 ENOG4108ZMI UPF0477 protein EQZ20_06890 ENOG4105C28 cystathionine EQZ20_06895 ENOG4105C28 cystathionine EQZ20_07055 ENOG4105C2M dna polymerase I EQZ20_07060 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EQZ20_07100 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EQZ20_07105 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQZ20_07130 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EQZ20_07140 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) EQZ20_07350 ENOG41068G1 EQZ20_07370 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase EQZ20_07405 ENOG4105CHR reductase EQZ20_07410 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily EQZ20_07450 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) EQZ20_07455 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EQZ20_07460 ENOG4105CIB oxidoreductase Domain protein EQZ20_07465 ENOG4107QTZ amino acid EQZ20_07475 ENOG4105DUM transcriptional regulator, lysR family EQZ20_07480 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EQZ20_07485 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EQZ20_07495 ENOG4108Q5Y Membrane EQZ20_07500 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase EQZ20_07510 ENOG41069ER domain protein EQZ20_07525 ENOG4105J7D transcriptional regulator EQZ20_07535 ENOG4105K7W phage-related replication protein EQZ20_07540 ENOG410635T phage-like element pbsx protein EQZ20_07580 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EQZ20_07600 ENOG4107XBN GntR Family Transcriptional Regulator EQZ20_07605 ENOG4105CPQ Dehydrogenase EQZ20_07610 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) EQZ20_07615 ENOG4105DMW Dehydrogenase reductase EQZ20_07620 ENOG4105CPQ Dehydrogenase EQZ20_07640 ENOG4105CJ3 phosphate transporter EQZ20_07645 ENOG4107GRR phosphate transport regulator EQZ20_07650 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EQZ20_07655 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EQZ20_07660 ENOG4108I5D sulfate abc transporter EQZ20_07665 ENOG4105ECW sulfate abc transporter EQZ20_07680 ENOG4105C2F Histidine kinase EQZ20_07685 ENOG4105EQD regulatoR EQZ20_07690 ENOG410769Z extracellular solute-binding protein family 1 EQZ20_07695 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EQZ20_07700 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EQZ20_07705 ENOG4105F5H Glycosyl Hydrolase Family 88 EQZ20_07720 ENOG4107R7I amino acid EQZ20_07730 ENOG4105C0H protease EQZ20_07740 ENOG4108ME1 Peptidase M55 D-aminopeptidase EQZ20_07745 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQZ20_07750 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQZ20_07755 ENOG4105C3U ABC transporter EQZ20_07765 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EQZ20_07770 ENOG4105DTQ mandelate racemase muconate lactonizing EQZ20_07775 ENOG4107SN7 NLP P60 protein EQZ20_07780 ENOG4108JQ7 (ABC) transporter EQZ20_07790 ENOG4107TUM Amidinotransferase EQZ20_07795 ENOG4108S4H thioesterase Superfamily protein EQZ20_07810 ENOG410839T multidrug resistance protein EQZ20_07815 ENOG41080TC multidrug resistance protein EQZ20_07820 ENOG4105CIY formyltetrahydrofolate deformylase EQZ20_07825 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EQZ20_07830 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EQZ20_07845 ENOG4105K56 Transcriptional regulator EQZ20_07850 ENOG4108ZHJ Organic hydroperoxide resistance protein EQZ20_07860 ENOG4107Y2X deaminase EQZ20_07865 ENOG4105CVJ phosphoglycerate mutase EQZ20_07885 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EQZ20_07890 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQZ20_07900 ENOG4105CJW magnesium transporter EQZ20_07910 ENOG4105V75 Transcriptional regulator EQZ20_07930 ENOG4105DQE DNA ligase EQZ20_07935 ENOG4105FDF Could be involved in DNA repair (By similarity) EQZ20_07940 ENOG4105BZU Histidine kinase EQZ20_07945 ENOG4107T5V SNARE associated Golgi EQZ20_07950 ENOG4107TS3 membrane protein, TerC EQZ20_07960 ENOG4108WZW RNA polymerase sigma EQZ20_07970 ENOG410681C small acid-soluble spore protein EQZ20_07980 ENOG4105D0M Protease HtpX homolog EQZ20_07995 ENOG4107RVG penicillin-binding protein EQZ20_08005 ENOG4108TGC Acyltransferase EQZ20_08010 ENOG4105BZU Histidine kinase EQZ20_08015 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EQZ20_08020 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EQZ20_08030 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EQZ20_08040 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate EQZ20_08055 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EQZ20_08060 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) EQZ20_08075 ENOG4105BZU Histidine kinase EQZ20_08080 ENOG41090MY MarR family Transcriptional regulator EQZ20_08085 ENOG4105ER2 Ompa motb domain protein EQZ20_08090 ENOG4105E14 MotA TolQ exbB proton channel EQZ20_08100 ENOG4108K88 Membrane EQZ20_08105 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EQZ20_08110 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase EQZ20_08115 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EQZ20_08120 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EQZ20_08140 ENOG4108YM7 Gcn5-related n-acetyltransferase EQZ20_08180 ENOG4105F0V Cell wall hydrolase EQZ20_08200 ENOG4105C59 p-type ATPase EQZ20_08210 ENOG4105DC7 peptidase M24 EQZ20_08220 ENOG4105CID antiterminator EQZ20_08230 ENOG4105KRI phosphocarrier protein (HPr EQZ20_08235 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EQZ20_08250 ENOG4105F6S Spore photoproduct lyase EQZ20_08260 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EQZ20_08265 ENOG4105CHR reductase EQZ20_08270 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EQZ20_08280 ENOG4105K4I Scp-like extracellular EQZ20_08290 ENOG4105BZU Histidine kinase EQZ20_08295 ENOG4105CHM Aminotransferase EQZ20_08310 ENOG4107R88 Chemotaxis protein (CheV) EQZ20_08320 ENOG4105UIN EQZ20_08330 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein EQZ20_08340 ENOG4105K6S Short-chain dehydrogenase reductase Sdr EQZ20_08345 ENOG4105EPM Diguanylate phosphodiesterase EQZ20_08350 ENOG4107IN1 Protein of unknown function (DUF1797) EQZ20_08355 ENOG4108XRC Protein of unknown function (DUF458) EQZ20_08385 ENOG4105NQC Flavodoxin EQZ20_08390 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) EQZ20_08405 ENOG4105D3R alkyl hydroperoxide reductase EQZ20_08410 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQZ20_08425 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EQZ20_08430 ENOG4105D06 uba thif-type nad fad binding protein EQZ20_08435 ENOG4105CVM Molybdenum cofactor synthesis domain protein EQZ20_08440 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein EQZ20_08445 ENOG4108ZAF Molybdopterin EQZ20_08450 ENOG41067WU Molybdopterin converting factor (Subunit 1) EQZ20_08460 ENOG4105BZ1 (ABC) transporter EQZ20_08465 ENOG4105BZ1 (ABC) transporter EQZ20_08475 ENOG4107X8C Efflux transporter RND family MFP subunit EQZ20_08480 ENOG4105C19 ABC transporter EQZ20_08485 ENOG4107RBB ABC transporter, permease EQZ20_08495 ENOG4105E98 transcriptional regulator DeoR family EQZ20_08500 ENOG4105DE4 1-phosphofructokinase EQZ20_08505 ENOG4105DM4 PTS System EQZ20_08510 ENOG4105C3F Signal peptidase i EQZ20_08525 ENOG4105C5H ABC transporter EQZ20_08550 ENOG4105BZU Histidine kinase EQZ20_08555 ENOG4107ZYR domain protein EQZ20_08570 ENOG4105CN5 Metallo-Beta-Lactamase EQZ20_08585 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EQZ20_08605 ENOG4105CPP Dehydrogenase, E1 component EQZ20_08610 ENOG4105C7S Dehydrogenase EQZ20_08615 ENOG4107QN2 dihydrolipoyl dehydrogenase EQZ20_08630 ENOG4105CXN decarboxylase EQZ20_08635 ENOG4105WBI UPF0223 protein EQZ20_08660 ENOG4105ECY inositol monophosphatase EQZ20_08675 ENOG4105CI3 gtp-binding protein typa EQZ20_08680 ENOG4105QA2 EQZ20_08685 ENOG4108INS Transcriptional regulator EQZ20_08690 ENOG4107SCK Monooxygenase EQZ20_08705 ENOG4108IAB Phoh family EQZ20_08720 ENOG4105CSV Glutaminase EQZ20_08725 ENOG4105ZPI UPF0358 protein EQZ20_08730 ENOG4105CNI cell division protein FtsW EQZ20_08735 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EQZ20_08745 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EQZ20_08755 ENOG4105BZ9 Cytochrome C oxidase, subunit I EQZ20_08760 ENOG4105CCU oxidase (Subunit III) EQZ20_08765 ENOG41064X9 cytochrome C oxidase subunit IV EQZ20_08780 ENOG41080XQ Signal transduction protein with cbs domains EQZ20_08785 ENOG4106UY4 Inherit from COG: Scp-like extracellular EQZ20_08795 ENOG4107QN1 sodium solute EQZ20_08800 ENOG4105CE7 Amidase, hydantoinase carbamoylase family EQZ20_08830 ENOG4106H78 methyltransferase EQZ20_08835 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EQZ20_08840 ENOG4105H20 Sporulation integral membrane protein YlbJ EQZ20_08845 ENOG41063PX domain protein EQZ20_08850 ENOG4105CDE UPF0348 protein EQZ20_08855 ENOG4105KNH Nucleic acid-binding protein EQZ20_08860 ENOG41067VY 50S ribosomal protein L32 EQZ20_08880 ENOG41074B2 UPF0747 protein EQZ20_08885 ENOG4108V6E Cell division protein mraZ EQZ20_08890 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EQZ20_08900 ENOG4105CJN penicillin-binding protein EQZ20_08905 ENOG4105CJN penicillin-binding protein EQZ20_08910 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EQZ20_08915 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EQZ20_08920 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EQZ20_08925 ENOG4105CNI cell division protein FtsW EQZ20_08930 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EQZ20_08935 ENOG4105D4A Cell wall formation (By similarity) EQZ20_08940 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) EQZ20_08945 ENOG4108R2U division initiation protein EQZ20_08955 ENOG4105K67 small basic protein EQZ20_08960 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EQZ20_08965 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EQZ20_08980 ENOG4105FFI sigma-e processing peptidase spoiiga EQZ20_08985 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQZ20_08995 ENOG4105DKW ABC transporter EQZ20_09005 ENOG4105WR5 sporulation protein, YlmC YmxH family EQZ20_09010 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EQZ20_09015 ENOG4105DFA alanine racemase domain protein EQZ20_09020 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EQZ20_09025 ENOG41067XK integral membrane protein EQZ20_09030 ENOG4105DBK s4 domain protein EQZ20_09050 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EQZ20_09055 ENOG4105C34 Pseudouridine synthase EQZ20_09060 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EQZ20_09070 ENOG4105CXT aspartate transcarbamylase EQZ20_09075 ENOG4105CD3 dihydroorotase EQZ20_09080 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EQZ20_09085 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EQZ20_09090 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EQZ20_09095 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) EQZ20_09100 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EQZ20_09115 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EQZ20_09135 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EQZ20_09140 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EQZ20_09145 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein EQZ20_09155 ENOG4105F23 Fibronectin-binding protein EQZ20_09165 ENOG4105DSJ YicC domain protein EQZ20_09170 ENOG4105KC4 UPF0296 protein EQZ20_09175 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EQZ20_09180 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) EQZ20_09185 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EQZ20_09190 ENOG4105C25 Primosomal protein n' EQZ20_09195 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EQZ20_09200 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EQZ20_09205 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EQZ20_09210 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EQZ20_09215 ENOG4108ZF3 Phosphatase EQZ20_09220 ENOG4105D9P serine threonine protein kinase EQZ20_09225 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EQZ20_09230 ENOG4105DJV ribulose-phosphate 3-epimerase EQZ20_09235 ENOG4105FJ0 thiamine EQZ20_09245 ENOG4105VB9 50S ribosomal protein l28 EQZ20_09250 ENOG4108ZAA Alkaline-shock protein EQZ20_09255 ENOG4105DP4 dak2 domain fusion protein ylov EQZ20_09265 ENOG4105EJQ L-serine dehydratase EQZ20_09270 ENOG4105CB5 ATP-dependent DNA helicase recG EQZ20_09275 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) EQZ20_09280 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EQZ20_09285 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EQZ20_09290 ENOG4105CHR reductase EQZ20_09295 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EQZ20_09300 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EQZ20_09305 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EQZ20_09310 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EQZ20_09315 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) EQZ20_09325 ENOG4105K5M 30s ribosomal protein S16 EQZ20_09330 ENOG4108BW8 UPF0109 protein EQZ20_09340 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EQZ20_09345 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EQZ20_09350 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EQZ20_09360 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EQZ20_09365 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EQZ20_09375 ENOG4105VM1 flagellar EQZ20_09380 ENOG4105CMV Succinyl-CoA synthetase subunit beta EQZ20_09385 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EQZ20_09390 ENOG4105C79 DNA protecting protein DprA EQZ20_09395 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EQZ20_09400 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) EQZ20_09405 ENOG4108HE4 integrase family EQZ20_09410 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) EQZ20_09415 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) EQZ20_09420 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) EQZ20_09425 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EQZ20_09430 ENOG4108ZC9 flagellar basal-body rod protein flgc EQZ20_09435 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EQZ20_09440 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EQZ20_09445 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EQZ20_09460 ENOG4106YF4 Flagellar biosynthesis chaperone EQZ20_09470 ENOG410696Y Flagellar hook-length control protein EQZ20_09475 ENOG410822I Flagellar hook capping protein EQZ20_09480 ENOG4108JQA flagellar EQZ20_09485 ENOG41068WV flagellar FlbD family protein EQZ20_09495 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EQZ20_09500 ENOG4105DD5 Flagellar motor switch protein EQZ20_09505 ENOG4107YTP response regulator receiver protein EQZ20_09515 ENOG4105CN7 Flagellar biosynthetic protein FliP EQZ20_09520 ENOG4105VS8 Flagellar biosynthetic protein fliq EQZ20_09525 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EQZ20_09530 ENOG4105D00 flagellar biosynthetic protein flhB EQZ20_09535 ENOG4105D7B Flagellar biosynthesis protein flha EQZ20_09540 ENOG4105FZW flagellar biosynthesis regulator FlhF EQZ20_09550 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EQZ20_09555 ENOG4105CBS Chea signal transduction histidine kinase EQZ20_09560 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis EQZ20_09570 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) EQZ20_09575 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQZ20_09585 ENOG4105CE9 30S ribosomal protein S2 EQZ20_09590 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EQZ20_09600 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EQZ20_09605 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EQZ20_09610 ENOG4105KNE Phosphatidate cytidylyltransferase EQZ20_09620 ENOG4105DZP Membrane-associated zinc metalloprotease EQZ20_09630 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EQZ20_09640 ENOG4105CYP glycoside hydrolase, family EQZ20_09655 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EQZ20_09660 ENOG4105CHV Transcription elongation factor NusA EQZ20_09665 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination EQZ20_09670 ENOG4105VHM ribosomal protein EQZ20_09675 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EQZ20_09680 ENOG4105W7A Protein of unknown function (DUF503) EQZ20_09685 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EQZ20_09690 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EQZ20_09695 ENOG4105DTN riboflavin biosynthesis protein ribF EQZ20_09700 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EQZ20_09705 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EQZ20_09715 ENOG4105C1V Peptidase, M16 EQZ20_09730 ENOG4105E35 Dipicolinate synthase subunit A EQZ20_09745 ENOG4107EV6 Inherit from COG: YD repeat protein EQZ20_09750 ENOG4106ANW SMI1_KNR4 EQZ20_09755 ENOG4106ANW SMI1_KNR4 EQZ20_09800 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EQZ20_09825 ENOG4105E4C Lytic transglycosylase catalytic EQZ20_09830 ENOG4105E4C Lytic transglycosylase catalytic EQZ20_09960 ENOG41068G1 EQZ20_10090 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQZ20_10120 ENOG4108NE4 EQZ20_10160 ENOG4107NTZ EQZ20_10340 ENOG4108J9Q DNA ligase EQZ20_10415 ENOG4106YR8 EQZ20_10420 ENOG41088HM EQZ20_10430 ENOG4106PTB DnaB-like helicase C terminal domain EQZ20_10435 ENOG4106IVX EQZ20_10445 ENOG4106J9J DNA polymerase EQZ20_10500 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EQZ20_10505 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQZ20_10515 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQZ20_10540 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EQZ20_10565 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EQZ20_10630 ENOG4108UV1 cellular component movement EQZ20_10635 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) EQZ20_10645 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EQZ20_10655 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQZ20_10665 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit EQZ20_10675 ENOG4105CNU cell division protein FtsK EQZ20_10680 ENOG4105FDP GntR family transcriptional regulator EQZ20_10700 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EQZ20_10705 ENOG4105XZV Protein of unknown function (DUF3243) EQZ20_10720 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EQZ20_10725 ENOG4105CEV competence damage-inducible protein EQZ20_10730 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EQZ20_10740 ENOG4105D48 metallophosphoesterase EQZ20_10745 ENOG4105MCT stage V sporulation protein S EQZ20_10750 ENOG4108IGT Dipeptidase EQZ20_10755 ENOG4105CPQ Dehydrogenase EQZ20_10760 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EQZ20_10765 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQZ20_10780 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EQZ20_10785 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EQZ20_10800 ENOG4107EV6 Inherit from COG: YD repeat protein EQZ20_10835 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase EQZ20_10865 ENOG4108Z66 YbaK ebsC protein EQZ20_10875 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EQZ20_10910 ENOG4108QY0 Membrane EQZ20_10915 ENOG4105XPP Protein of unknown function (DUF1275) EQZ20_10925 ENOG4108J8C transporter major facilitator family protein EQZ20_10935 ENOG41080BT SNARE associated Golgi EQZ20_10940 ENOG4105FQP Beta-lactamase EQZ20_10945 ENOG41087PP glycosyltransferase MGT family EQZ20_10950 ENOG4107QTZ amino acid EQZ20_10970 ENOG4105M4P Tetr family transcriptional regulator EQZ20_10975 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein EQZ20_10980 ENOG4107S9F NmrA family EQZ20_10985 ENOG4108X3M OsmC Ohr family protein EQZ20_10990 ENOG4107E54 Small Multidrug Resistance protein EQZ20_11010 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EQZ20_11015 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EQZ20_11025 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EQZ20_11030 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQZ20_11035 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQZ20_11040 ENOG4105U6W MutT NUDIX family protein EQZ20_11045 ENOG4105DRR Transcriptional regulator, GntR family EQZ20_11130 ENOG4106F1P AAA ATPase, central domain protein EQZ20_11135 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EQZ20_11140 ENOG4105CXI aluminum resistance protein EQZ20_11145 ENOG4105KV4 Transcriptional regulator EQZ20_11150 ENOG4105C5F glutamine synthetase EQZ20_11170 ENOG4107T94 Endo-14-beta-xylanase EQZ20_11230 ENOG4105NCW Trka-c domain protein EQZ20_11235 ENOG4107S91 Sodium hydrogen exchanger EQZ20_11260 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EQZ20_11270 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EQZ20_11320 ENOG4108MK9 spermidine N(1)-acetyltransferase EQZ20_11355 ENOG41067SE Tetr family transcriptional regulator EQZ20_11370 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EQZ20_11390 ENOG4108HWY Beta-lactamase EQZ20_11395 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EQZ20_11405 ENOG4108SVB resolvase EQZ20_11410 ENOG4105VPS UPF0291 protein EQZ20_11415 ENOG4105CV1 Transketolase (EC 2.2.1.1) EQZ20_11425 ENOG4105VXM UPF0154 protein EQZ20_11435 ENOG4107QIV Cytochrome c biogenesis protein EQZ20_11460 ENOG41076DU acid-soluble spore protein P EQZ20_11470 ENOG4108I0Z Aconitate hydratase EQZ20_11475 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQZ20_11490 ENOG41067CD Small, acid-soluble spore protein Tlp EQZ20_11500 ENOG4105MI2 EQZ20_11510 ENOG4105W8X HesB YadR YfhF-family protein EQZ20_11515 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EQZ20_11520 ENOG4105K4P CoA-binding domain protein EQZ20_11525 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQZ20_11535 ENOG4105CMD Transcriptional regulator, GntR family EQZ20_11550 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) EQZ20_11555 ENOG4107QNK )-transporter EQZ20_11560 ENOG4105CHR reductase EQZ20_11590 ENOG4105R3A Nitrate reductase EQZ20_11595 ENOG4108IUE nitrate reductase beta subunit EQZ20_11630 ENOG4107V6Q Cyclic nucleotide-binding domain EQZ20_11650 ENOG4105DSQ Nitric oxide reductase EQZ20_11655 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) EQZ20_11660 ENOG4106U2H Protein of unknown function (DUF1360) EQZ20_11665 ENOG4107QWR cellulase (EC 3.2.1.4) EQZ20_11675 ENOG4108428 Inherit from COG: -acetyltransferase EQZ20_11685 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EQZ20_11690 ENOG4108UXE Protein tyrosine phosphatase EQZ20_11695 ENOG4105D6J arsenicaL-resistance protein EQZ20_11700 ENOG41082YX Transcriptional regulator, arsr family EQZ20_11710 ENOG4108V4B ThiJ pfpI EQZ20_11730 ENOG4105KMT branched-chain amino acid EQZ20_11735 ENOG4108UMN azlc family EQZ20_11740 ENOG4107U9B transcriptional regulator EQZ20_11760 ENOG41060WC Enoyl-CoA hydratase EQZ20_11765 ENOG4105C26 Dehydrogenase EQZ20_11770 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EQZ20_11775 ENOG4105C1G acyl-Coa dehydrogenase EQZ20_11780 ENOG4105W1Y Transcriptional regulator EQZ20_11790 ENOG4105DQ4 alcohol dehydrogenase EQZ20_11795 ENOG4108Y4K DNA-binding transcriptional activator EQZ20_11800 ENOG4105D8G Major Facilitator superfamily EQZ20_11805 ENOG41090UD (LipO)protein EQZ20_11835 ENOG4105CPC Aldo Keto reductase EQZ20_11840 ENOG410904A RNA polymerase EQZ20_11845 ENOG4105DG6 mannose-6-phosphate isomerase EQZ20_11850 ENOG4105DM4 PTS System EQZ20_11860 ENOG4107QIV Cytochrome c biogenesis protein EQZ20_11890 ENOG4105DVE abc transporter atp-binding protein EQZ20_11895 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EQZ20_11910 ENOG4107R5R arsenical pump membrane protein EQZ20_11930 ENOG4105CSC Glucose uptake protein EQZ20_11940 ENOG4105F32 YngK protein EQZ20_11950 ENOG4105F1A Pyruvate formate-lyase EQZ20_11955 ENOG4105C6N Formate acetyltransferase EQZ20_11960 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family EQZ20_11990 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EQZ20_11995 ENOG4107QX3 carboxylase EQZ20_12000 ENOG4105E39 Enoyl-CoA hydratase EQZ20_12005 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EQZ20_12010 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit EQZ20_12015 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EQZ20_12020 ENOG4105CEY Amp-dependent synthetase and ligase EQZ20_12025 ENOG4105C1G acyl-Coa dehydrogenase EQZ20_12035 ENOG4105KVH Transcriptional regulator EQZ20_12040 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EQZ20_12045 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EQZ20_12055 ENOG4105H67 Protein of unknown function (DUF421) EQZ20_12060 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EQZ20_12065 ENOG41061P3 phosphosulfolactate synthase EQZ20_12075 ENOG4105DIA mandelate racemase muconate lactonizing EQZ20_12080 ENOG4107RCC Major Facilitator Superfamily EQZ20_12100 ENOG4105BZ8 glutamate synthase EQZ20_12105 ENOG4105CBC glutamate synthase EQZ20_12110 ENOG4105C5Q Transcriptional regulator EQZ20_12140 ENOG4105BZ1 (ABC) transporter EQZ20_12145 ENOG4105DGI Alkaline phosphatase EQZ20_12160 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQZ20_12165 ENOG4108J2R molybdopterin oxidoreductase EQZ20_12175 ENOG4105I03 Flagellin EQZ20_12195 ENOG4108Q8B Spore germination protein EQZ20_12200 ENOG4108NHD germination protein EQZ20_12240 ENOG4105D29 Helix-turn-helix type 11 domain protein EQZ20_12250 ENOG4105C8Q Methyl-accepting chemotaxis EQZ20_12255 ENOG4108Z7R Chaperone CsaA EQZ20_12260 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQZ20_12270 ENOG4108RZE Tetr family transcriptional regulator EQZ20_12285 ENOG4108W8B Beta-lactamase domain protein EQZ20_12310 ENOG4105KTU Transcriptional regulator, arsr family EQZ20_12320 ENOG4105CUB amino acid EQZ20_12330 ENOG4105C5E polysaccharide biosynthesis protein EQZ20_12345 ENOG4107T8Q Glycosyl transferase (Group 1 EQZ20_12350 ENOG4108SJC Membrane EQZ20_12380 ENOG41069ER domain protein EQZ20_12385 ENOG4105C9U ATP-dependent DNA helicase RecQ EQZ20_12455 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EQZ20_12460 ENOG4105DDN Pentapeptide repeat-containing protein EQZ20_12475 ENOG410829K Lysine exporter protein (Lyse ygga) EQZ20_12480 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EQZ20_12510 ENOG4105SF0 DinB family EQZ20_12515 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EQZ20_12520 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EQZ20_12535 ENOG4108IUW ABC transporter EQZ20_12545 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EQZ20_12575 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EQZ20_12580 ENOG4105SCY DNAK suppressor EQZ20_12585 ENOG4105F0F Oxalate decarboxylase EQZ20_12615 ENOG4105EVH UPF0753 protein EQZ20_12620 ENOG4108TWJ NADH dehydrogenase subunit 5 EQZ20_12625 ENOG4105GPN Uncharacterized conserved protein (DUF2294) EQZ20_12650 ENOG4105C26 Dehydrogenase EQZ20_12655 ENOG4105KNA -acetyltransferase EQZ20_12665 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EQZ20_12670 ENOG4105GVJ transcriptional regulator EQZ20_12675 ENOG4105EWU Squalene--hopene cyclase EQZ20_12680 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EQZ20_12685 ENOG4105C8J )-transporter EQZ20_12690 ENOG4105C09 Bile acid EQZ20_12695 ENOG4105C7S Dehydrogenase EQZ20_12700 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EQZ20_12705 ENOG4107T89 von Willebrand factor, type A EQZ20_12710 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EQZ20_12720 ENOG4105K4H Nlp p60 protein EQZ20_12745 ENOG4105FR1 rard protein EQZ20_12755 ENOG4108YQE rare lipoprotein a EQZ20_12765 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EQZ20_12780 ENOG4105FBA Phospholipase Carboxylesterase EQZ20_12815 ENOG4108VXD carboxy-peptidase EQZ20_12820 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EQZ20_12825 ENOG4108PJD permease EQZ20_12840 ENOG4106Z5R EQZ20_12845 ENOG410841Q phosphoesterase PA-phosphatase related protein EQZ20_12860 ENOG4105VSD UPF0346 protein EQZ20_12870 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EQZ20_12875 ENOG4108TSC N-acetyltransferase EQZ20_12880 ENOG4107S4Y M20 DapE family protein YgeY EQZ20_12895 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EQZ20_12910 ENOG4105E0X reductase EQZ20_12945 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) EQZ20_12950 ENOG41090WU lipolytic protein G-D-S-L family EQZ20_12955 ENOG4108KF3 Electron transport protein SCO1 SenC EQZ20_12970 ENOG4105C7B Threonine dehydratase EQZ20_12980 ENOG4108UT2 hemolysin iii EQZ20_12990 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) EQZ20_13010 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EQZ20_13015 ENOG4107YX5 Pfam:DUF548 EQZ20_13025 ENOG4105C01 Dihydroxy-acid dehydratase EQZ20_13040 ENOG4108V06 Glutathione peroxidase EQZ20_13045 ENOG4105CKU formyltetrahydrofolate synthetase EQZ20_13050 ENOG4105CVG Homoserine O-transsuccinylase EQZ20_13060 ENOG4108QBV Monogalactosyldiacylglycerol synthase EQZ20_13100 ENOG41081VK Ribonuclease EQZ20_13120 ENOG410890F Dynamin family EQZ20_13140 ENOG41065KQ synthase EQZ20_13150 ENOG4105C2W permease EQZ20_13155 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) EQZ20_13165 ENOG4105DVT helicase EQZ20_13175 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EQZ20_13185 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) EQZ20_13190 ENOG4108UKS UPF0398 protein EQZ20_13200 ENOG4107X2U Inherit from COG: Exonuclease-like protein EQZ20_13215 ENOG4105EFI regulatoR EQZ20_13220 ENOG4105BZU Histidine kinase EQZ20_13225 ENOG4105DTD Dehydrogenase EQZ20_13230 ENOG4105CMU LysR family (Transcriptional regulator EQZ20_13235 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EQZ20_13250 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) EQZ20_13255 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EQZ20_13275 ENOG4108UXE Protein tyrosine phosphatase EQZ20_13280 ENOG4105D6J arsenicaL-resistance protein EQZ20_13285 ENOG41082YX Transcriptional regulator, arsr family EQZ20_13340 ENOG4105BZ4 penicillin-binding protein EQZ20_13355 ENOG4105CSM endonuclease III EQZ20_13370 ENOG4105CHM Aminotransferase EQZ20_13380 ENOG4105YAC EQZ20_13385 ENOG4105DVT helicase EQZ20_13390 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) EQZ20_13395 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EQZ20_13400 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EQZ20_13410 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EQZ20_13415 ENOG4105CPK Glycosyl transferase (Group 1 EQZ20_13420 ENOG4105FJR Lmbe family EQZ20_13425 ENOG4108Z5K methylglyoxal synthase EQZ20_13430 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EQZ20_13435 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase EQZ20_13440 ENOG4108JYZ YitT family EQZ20_13460 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EQZ20_13475 ENOG4108SXZ UPF0302 protein EQZ20_13480 ENOG41068YB TPR repeat-containing protein EQZ20_13495 ENOG4105CIH Imidazole acetol-phosphate transaminase EQZ20_13500 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EQZ20_13505 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EQZ20_13515 ENOG4105DK0 Indole-3-glycerol phosphate synthase EQZ20_13520 ENOG4108I0Q anthranilate phosphoribosyltransferase EQZ20_13525 ENOG4105CRQ synthase (Component I) EQZ20_13530 ENOG4105KHN chorismate mutase EQZ20_13535 ENOG4105D49 3-dehydroquinate synthase EQZ20_13540 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EQZ20_13545 ENOG4105BZU Histidine kinase EQZ20_13550 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EQZ20_13555 ENOG4105EAH synthase EQZ20_13560 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EQZ20_13565 ENOG4105XXQ heptaprenyl diphosphate synthase component I EQZ20_13575 ENOG4105EUJ GTP cyclohydrolase i EQZ20_13580 ENOG4105K70 DNA-binding protein EQZ20_13585 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) EQZ20_13605 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EQZ20_13610 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EQZ20_13615 ENOG41065D1 EQZ20_13620 ENOG4105S2F EQZ20_13635 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EQZ20_13640 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EQZ20_13645 ENOG4105CAT Cytidine monophosphate kinase EQZ20_13650 ENOG4105MSI germination protein ypeb EQZ20_13665 ENOG4105HDK L-asparaginase EQZ20_13670 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase EQZ20_13685 ENOG4107RGJ metallophosphoesterase EQZ20_13700 ENOG4105I7S Abortive infection protein EQZ20_13705 ENOG4105C9U ATP-dependent DNA helicase RecQ EQZ20_13710 ENOG4105T7X EQZ20_13720 ENOG4108SAX Membrane EQZ20_13725 ENOG4108JQ1 Dehydrogenase EQZ20_13730 ENOG4105DR5 peptidase EQZ20_13750 ENOG4105BZU Histidine kinase EQZ20_13755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQZ20_13760 ENOG4105CRE cytochrome C EQZ20_13765 ENOG4107TWT Cytochrome c biogenesis protein EQZ20_13770 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQZ20_13775 ENOG4105FE9 pseudouridine synthase EQZ20_13785 ENOG4108JIC nucleoside recognition domain protein EQZ20_13790 ENOG4105DZ1 carboxypeptidase EQZ20_13800 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EQZ20_13805 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EQZ20_13820 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EQZ20_13825 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EQZ20_13830 ENOG4108R6K riboflavin synthase, subunit alpha EQZ20_13835 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EQZ20_13855 ENOG4105DQ6 Transposase EQZ20_13860 ENOG4105MYT Heat shock protein EQZ20_13875 ENOG4107ZE5 PPIases accelerate the folding of proteins EQZ20_13880 ENOG4105PTM secreted protein EQZ20_13885 ENOG4105K7W phage-related replication protein EQZ20_13890 ENOG4105BZU Histidine kinase EQZ20_13905 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EQZ20_13920 ENOG4105G6R Stage v sporulation protein ae EQZ20_13930 ENOG4105CZ3 stage V sporulation protein ad EQZ20_13935 ENOG41090VF Stage v sporulation protein ac EQZ20_13950 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQZ20_13955 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EQZ20_13960 ENOG41082AN stage II sporulation protein EQZ20_13965 ENOG4105DZ1 carboxypeptidase EQZ20_13970 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) EQZ20_13975 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EQZ20_13980 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQZ20_13990 ENOG4105I3K Ferric uptake regulator, Fur family EQZ20_13995 ENOG4105MZ9 stage II sporulation protein m EQZ20_14000 ENOG4105CK1 PTS System EQZ20_14010 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EQZ20_14025 ENOG4107YB6 acetyltransferase, (GNAT) family EQZ20_14035 ENOG4108YZ4 nudix hydrolase EQZ20_14045 ENOG4105PF9 Transcriptional regulator EQZ20_14055 ENOG4105CPC Aldo Keto reductase EQZ20_14060 ENOG4105DXI Major Facilitator superfamily EQZ20_14065 ENOG4107U9B transcriptional regulator EQZ20_14070 ENOG4108M26 parallel beta-helix repeat protein EQZ20_14090 ENOG4106HZJ EQZ20_14105 ENOG4108XET gCN5-related N-acetyltransferase EQZ20_14135 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EQZ20_14160 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase EQZ20_14175 ENOG4105DA5 (ABC) transporter EQZ20_14205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQZ20_14235 ENOG4105K7W phage-related replication protein EQZ20_14240 ENOG4108IXY short-chain dehydrogenase reductase EQZ20_14245 ENOG41069FQ Metallo-beta-lactamase superfamily EQZ20_14250 ENOG4105II7 pyrroline-5-carboxylate reductase EQZ20_14265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EQZ20_14280 ENOG4105WDJ 50S ribosomal protein L33 EQZ20_14285 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EQZ20_14290 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EQZ20_14295 ENOG4108TZY GntR Family Transcriptional Regulator EQZ20_14300 ENOG4105CS2 ec 3.2.1.21 EQZ20_14305 ENOG4105CK1 PTS System EQZ20_14315 ENOG4105VZJ PTS System EQZ20_14325 ENOG4105G6Z alkaline phosphatase EQZ20_14330 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQZ20_14335 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EQZ20_14340 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EQZ20_14350 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) EQZ20_14360 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EQZ20_14365 ENOG4108HNZ carboxyl transferase EQZ20_14375 ENOG4108QEG Membrane EQZ20_14380 ENOG4105CDA abc transporter atp-binding protein EQZ20_14385 ENOG4105E5Q amino acid AbC transporter EQZ20_14390 ENOG4108HW3 (ABC) transporter EQZ20_14400 ENOG4108Y6J UPF0403 protein EQZ20_14405 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) EQZ20_14415 ENOG4105C7S Dehydrogenase EQZ20_14420 ENOG4105CPP Dehydrogenase, E1 component EQZ20_14435 ENOG4105CKM Branched-chain carboxylic acid kinase EQZ20_14440 ENOG4107RDP Dehydrogenase EQZ20_14450 ENOG4108JUB Transcriptional regulator EQZ20_14455 ENOG4106CCJ Protein of unknown function (DUF2627) EQZ20_14460 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EQZ20_14465 ENOG4105JQZ Methyltransferase EQZ20_14470 ENOG4107QQR Sporulation EQZ20_14475 ENOG4105S1Z Stage IV sporulation protein B EQZ20_14480 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EQZ20_14485 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EQZ20_14490 ENOG4105DX0 Hemolysin A EQZ20_14495 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EQZ20_14500 ENOG4105CTB Polyprenyl synthetase EQZ20_14505 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EQZ20_14510 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EQZ20_14515 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EQZ20_14520 ENOG4105M7K Involved in the transcription termination process (By similarity) EQZ20_14525 ENOG4108ZSR alkaline shock protein EQZ20_14530 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EQZ20_14550 ENOG410644B Stage III sporulation protein af EQZ20_14560 ENOG4105KQ4 Stage iii sporulation protein ad EQZ20_14565 ENOG4108CQH stage III sporulation protein AC EQZ20_14570 ENOG4105KR5 Stage iii sporulation protein EQZ20_14575 ENOG4105CD2 stage iii sporulation protein aa EQZ20_14585 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EQZ20_14590 ENOG4105DC7 peptidase M24 EQZ20_14595 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EQZ20_14605 ENOG4105CBJ Metal-dependent enzyme EQZ20_14625 ENOG4105KST dependent repressor EQZ20_14630 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) EQZ20_14635 ENOG4105WZW rhodanese family EQZ20_14645 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EQZ20_14655 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EQZ20_14660 ENOG4105C0D helicase EQZ20_14685 ENOG4105VFR signal peptidase EQZ20_14725 ENOG4106855 Competence protein EQZ20_14760 ENOG4105C5X domain protein EQZ20_14795 ENOG4105TMB Formate nitrite transporter EQZ20_14805 ENOG4105E0M Sulfatase EQZ20_14825 ENOG4107ZXI Rhomboid family EQZ20_14830 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EQZ20_14835 ENOG4105WDJ 50S ribosomal protein L33 EQZ20_14845 ENOG41068DG YceG-like family EQZ20_14850 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EQZ20_14855 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EQZ20_14860 ENOG4105E2Z phosphate ABC transporter (Permease EQZ20_14865 ENOG4105C8U phosphate abc transporter EQZ20_14870 ENOG4105CVA phosphate EQZ20_14875 ENOG4107RF6 penicillin-binding protein EQZ20_14885 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EQZ20_14890 ENOG4105SXS Protein of unknown function (DUF456) EQZ20_14905 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EQZ20_14910 ENOG41063Y9 EQZ20_14915 ENOG4108U5J '-nucleotidase EQZ20_14920 ENOG4105N80 Ferric uptake regulator, Fur family EQZ20_14930 ENOG4105FDK ABC transporter EQZ20_14935 ENOG4108JYZ YitT family EQZ20_14940 ENOG41069ZM Protein of unknown function (DUF2624) EQZ20_14945 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EQZ20_14960 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EQZ20_14965 ENOG4105EGD dinuclear metal center protein, YbgI family EQZ20_14975 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) EQZ20_15005 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQZ20_15010 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EQZ20_15020 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EQZ20_15030 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EQZ20_15035 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit EQZ20_15040 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) EQZ20_15050 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EQZ20_15055 ENOG4105KG3 cytidine deaminase EQZ20_15060 ENOG4107YR5 Diacylglycerol kinase EQZ20_15065 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EQZ20_15070 ENOG4105CTJ Metal Dependent Phosphohydrolase EQZ20_15075 ENOG4105C9A Phoh family EQZ20_15080 ENOG4105EI1 sporulation protein yqfd EQZ20_15085 ENOG41068P3 sporulation protein YqfC EQZ20_15095 ENOG4105DI5 UPF0365 protein EQZ20_15100 ENOG4105F7J membrane-bound serine protease EQZ20_15105 ENOG4105KTH gatB Yqey EQZ20_15110 ENOG4105VCC 30S ribosomal protein S21 EQZ20_15120 ENOG4105VRR gCN5-related N-acetyltransferase EQZ20_15130 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQZ20_15135 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EQZ20_15140 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EQZ20_15145 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EQZ20_15150 ENOG4105CFG Acts as a chaperone (By similarity) EQZ20_15155 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EQZ20_15160 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EQZ20_15165 ENOG4105CSA Coproporphyrinogen iii oxidase EQZ20_15170 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EQZ20_15180 ENOG4108ZRV stage ii sporulation protein p EQZ20_15195 ENOG4105TQK DNA polymerase iii, delta' subunit EQZ20_15205 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EQZ20_15210 ENOG4108UK2 deaminase EQZ20_15215 ENOG4105KQC Competence protein EQZ20_15225 ENOG4108D32 Methyltransferase EQZ20_15235 ENOG4108WF2 Metal Dependent Phosphohydrolase EQZ20_15240 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EQZ20_15245 ENOG410812S Rna-binding protein EQZ20_15250 ENOG4105E2X shikimate dehydrogenase EQZ20_15255 ENOG4105CQW ribosome biogenesis GTPase YqeH EQZ20_15260 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EQZ20_15280 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) EQZ20_15285 ENOG4108JB9 formate dehydrogenase EQZ20_15295 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQZ20_15300 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EQZ20_15325 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EQZ20_15330 ENOG4105ES4 Nitrilase EQZ20_15335 ENOG4105CK7 Sodium proline symporter EQZ20_15395 ENOG4107RT3 EamA-like transporter family EQZ20_15410 ENOG4105EA8 2-Nitropropane dioxygenase EQZ20_15425 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EQZ20_15435 ENOG4108MEJ flavin reductase domain protein EQZ20_15460 ENOG4107R16 Multicopper oxidase EQZ20_15465 ENOG4105BZU Histidine kinase EQZ20_15470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQZ20_15475 ENOG41090UD (LipO)protein EQZ20_15485 ENOG4105EYF MMPL domain protein EQZ20_15490 ENOG4108VB1 regulatoR EQZ20_15495 ENOG4105ENE Histidine kinase EQZ20_15540 ENOG41090AA EQZ20_15550 ENOG41080HJ 6-phospho 3-hexuloisomerase EQZ20_15555 ENOG4108VA3 3-hexulose-6-phosphate synthase EQZ20_15560 ENOG4105KVH Transcriptional regulator EQZ20_15575 ENOG4105WH1 Two component transcriptional regulator luxr family EQZ20_15580 ENOG4105BZU Histidine kinase EQZ20_15585 ENOG4105XXY Thioredoxin EQZ20_15590 ENOG41087NI Sulfite exporter TauE/SafE EQZ20_15595 ENOG4105VFE sira family EQZ20_15600 ENOG4107TPS domain protein EQZ20_15605 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EQZ20_15610 ENOG4105VFE sira family EQZ20_15615 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EQZ20_15620 ENOG4105XTG Pfam:DUF156 EQZ20_15640 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein EQZ20_15675 ENOG4105F8D glycoside hydrolase family 4 EQZ20_15680 ENOG4108HCJ Hydrolase EQZ20_15685 ENOG4105CAY ferredoxin--nadp reductase EQZ20_15695 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EQZ20_15705 ENOG41090U3 tautomerase EQZ20_15710 ENOG4108MEK Metal-binding protein YodA EQZ20_15745 ENOG4105D82 Glutamate dehydrogenase EQZ20_15770 ENOG4105DSG hydrolase family 43 EQZ20_15775 ENOG4105CT4 transporter EQZ20_15780 ENOG4105ID8 Transcriptional regulator, ARAC family EQZ20_15785 ENOG4107QP6 Xylose isomerase domain protein TIM barrel EQZ20_15790 ENOG4105CIB oxidoreductase Domain protein EQZ20_15795 ENOG4108HKT sucrose-6-phosphate hydrolase EQZ20_15800 ENOG4105F3R pts system mannose fructose sorbose family iid EQZ20_15805 ENOG4105ETZ PTS System EQZ20_15810 ENOG4108IQ3 PTS system EQZ20_15815 ENOG4105YHU PTS system EQZ20_15820 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQZ20_15825 ENOG4105C85 amino acid EQZ20_15830 ENOG4105G7B Protein of unknown function (DUF2992) EQZ20_15840 ENOG4107Y9E nuclease EQZ20_15860 ENOG41068K0 YCII-related domain EQZ20_15880 ENOG4105CV8 reductase EQZ20_15885 ENOG4105F27 Major Facilitator EQZ20_15890 ENOG4105KVH Transcriptional regulator EQZ20_15895 ENOG4105EXQ uroporphyrinogen iii synthase hem4 EQZ20_15905 ENOG4107RSM transcriptional regulator EQZ20_15910 ENOG4105D94 Major Facilitator Superfamily EQZ20_15920 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EQZ20_15925 ENOG41082JN Transcriptional regulator EQZ20_15935 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQZ20_15965 ENOG4105C28 cystathionine EQZ20_15975 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EQZ20_15980 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) EQZ20_15995 ENOG4107XRG penicillin-binding protein EQZ20_16000 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EQZ20_16010 ENOG4105CFP Peptidase U32 EQZ20_16015 ENOG4105XYU peptidase (U32 family) EQZ20_16020 ENOG4108VQJ O-methyltransferase EQZ20_16025 ENOG4105HHA aminodeoxychorismate lyase EQZ20_16035 ENOG4105VPH UPF0473 protein EQZ20_16040 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EQZ20_16045 ENOG4105VBH UPF0297 protein EQZ20_16050 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EQZ20_16055 ENOG4105C02 permease EQZ20_16060 ENOG4105CDA abc transporter atp-binding protein EQZ20_16065 ENOG4105CT1 (ABC) transporter EQZ20_16070 ENOG4105EAD ABC transporter EQZ20_16075 ENOG4105DRP amino acid AbC transporter EQZ20_16085 ENOG41060CR EQZ20_16095 ENOG4105C7H Helicase, RecD TraA family EQZ20_16105 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EQZ20_16110 ENOG4105C3J Cysteine desulfurase EQZ20_16120 ENOG4105D1H recombination factor protein RarA EQZ20_16130 ENOG4105CUZ uba thif-type nad fad binding protein EQZ20_16140 ENOG4105C9M aspartyl-trna synthetase EQZ20_16145 ENOG4105CUT histidyl-tRNA synthetase EQZ20_16150 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQZ20_16155 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EQZ20_16160 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EQZ20_16165 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EQZ20_16170 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EQZ20_16175 ENOG41067VP Protein of unknown function (DUF1049) EQZ20_16180 ENOG4105NCW Trka-c domain protein EQZ20_16185 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EQZ20_16195 ENOG4105CKP Polysaccharide Biosynthesis Protein EQZ20_16200 ENOG4108QG2 Membrane EQZ20_16205 ENOG4105NAP EQZ20_16210 ENOG4105VIE preprotein translocase, subunit YajC EQZ20_16215 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) EQZ20_16220 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EQZ20_16225 ENOG41061AI Protein of unknown function (DUF2905) EQZ20_16230 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EQZ20_16235 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EQZ20_16250 ENOG41069DP small acid-soluble spore protein EQZ20_16260 ENOG4105K7W phage-related replication protein EQZ20_16280 ENOG4105CDY transcriptional regulatory protein EQZ20_16290 ENOG4106678 morphogenetic protein associated with SpoVID EQZ20_16295 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EQZ20_16300 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EQZ20_16305 ENOG4108IYU L-aspartate oxidase EQZ20_16320 ENOG4105CQC Prephenate dehydratase EQZ20_16325 ENOG41090I5 UPF0735 ACT domain-containing protein EQZ20_16330 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EQZ20_16340 ENOG4105K46 50S ribosomal protein l27 EQZ20_16345 ENOG4105X36 (ribosomal) protein EQZ20_16350 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EQZ20_16370 ENOG41082BM Transcriptional regulator, arsr family EQZ20_16375 ENOG4107QMS site-determining protein EQZ20_16380 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EQZ20_16385 ENOG4105YHC Rod shape-determining protein MreD EQZ20_16390 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EQZ20_16395 ENOG4105DFF Rod shape-determining protein mreb EQZ20_16400 ENOG4105W5Q DNA repair protein (RadC EQZ20_16405 ENOG4108Z03 MAF-like protein EQZ20_16415 ENOG4106A3R peptidase EQZ20_16420 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EQZ20_16425 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EQZ20_16435 ENOG4106AR7 Spore coat protein EQZ20_16440 ENOG41068KH stage VI sporulation protein D EQZ20_16445 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EQZ20_16450 ENOG4105D52 delta-aminolevulinic acid dehydratase EQZ20_16460 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EQZ20_16470 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EQZ20_16480 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EQZ20_16485 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EQZ20_16490 ENOG4108IUQ atp-dependent protease EQZ20_16495 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EQZ20_16500 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EQZ20_16510 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EQZ20_16515 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EQZ20_16520 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EQZ20_16525 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EQZ20_16530 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EQZ20_16535 ENOG4108ZP8 Acetolactate synthase small subunit EQZ20_16540 ENOG4105C7K acetolactate synthase EQZ20_16545 ENOG4105CM2 brancheD-chain amino acid aminotransferase EQZ20_16555 ENOG4107R37 Glutamate dehydrogenase EQZ20_16585 ENOG4105M59 Phosphodiesterase, mj0936 family EQZ20_16590 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EQZ20_16595 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EQZ20_16600 ENOG4108XJQ germination protein EQZ20_16605 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EQZ20_16610 ENOG41067TZ transcriptional regulator, MarR family EQZ20_16615 ENOG4105PFC Transcriptional regulator EQZ20_16620 ENOG4107Y5K Resolvase EQZ20_16770 ENOG4105IG6 Phage terminase, large subunit EQZ20_16855 ENOG4108PNI recT protein EQZ20_16860 ENOG4108NF7 phage-type endonuclease EQZ20_16900 ENOG41067QW Transcriptional regulator EQZ20_16920 ENOG4105PFC Transcriptional regulator EQZ20_16935 ENOG4105E33 succinate dehydrogenase EQZ20_16945 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit EQZ20_16960 ENOG4105CFH Aspartokinase EQZ20_16970 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EQZ20_16975 ENOG4105K63 Thioredoxin EQZ20_16980 ENOG4105C10 Electron transfer flavoprotein EQZ20_16985 ENOG4105BZJ Electron transfer flavoprotein EQZ20_16990 ENOG41060WC Enoyl-CoA hydratase EQZ20_16995 ENOG4107Z3H Transcriptional regulator, TetR family EQZ20_17000 ENOG4105CEY Amp-dependent synthetase and ligase EQZ20_17010 ENOG4105C98 muts2 protein EQZ20_17015 ENOG4105DCG PHP domain protein EQZ20_17025 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) EQZ20_17030 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EQZ20_17045 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EQZ20_17050 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EQZ20_17055 ENOG4108RWN rrna methyltransferase EQZ20_17060 ENOG41067MF small acid-soluble spore protein EQZ20_17070 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EQZ20_17080 ENOG4105CKV Membrane EQZ20_17100 ENOG4105DRS transport system, permease EQZ20_17115 ENOG4108MDK Dehydrogenase EQZ20_17120 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase EQZ20_17125 ENOG4105EF1 ribulokinase EQZ20_17130 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) EQZ20_17135 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase EQZ20_17140 ENOG4105CN9 Peptidase m42 family protein EQZ20_17150 ENOG410696E Membrane EQZ20_17155 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EQZ20_17160 ENOG4105VJV 50s ribosomal protein L35 EQZ20_17165 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EQZ20_17170 ENOG41067MG lrgb family EQZ20_17180 ENOG4105DGI Alkaline phosphatase EQZ20_17185 ENOG4105DY9 regulatoR EQZ20_17190 ENOG4108HRK Histidine kinase EQZ20_17195 ENOG4105U0R haloacid dehalogenase-like hydrolase EQZ20_17205 ENOG4105C22 threonyL-tRNA synthetase EQZ20_17210 ENOG4108TDW sporulation protein YtxC EQZ20_17230 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EQZ20_17240 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) EQZ20_17245 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EQZ20_17250 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EQZ20_17260 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EQZ20_17265 ENOG4105C2M dna polymerase I EQZ20_17270 ENOG4105BZU Histidine kinase EQZ20_17275 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQZ20_17280 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EQZ20_17285 ENOG4108HMX isocitrate dehydrogenase (NADP) EQZ20_17290 ENOG4105BZN citrate synthase EQZ20_17295 ENOG4108VMM UPF0756 membrane protein EQZ20_17300 ENOG4108REF Sporulation integral membrane protein ytvi EQZ20_17305 ENOG4105FS0 cytoplasmic membrane protein EQZ20_17310 ENOG4105CA9 Pyruvate kinase EQZ20_17315 ENOG4105CTQ phosphohexokinase EQZ20_17320 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) EQZ20_17330 ENOG4105C6K Malic enzyme EQZ20_17335 ENOG4105C0B DNA polymerase III (alpha subunit) EQZ20_17340 ENOG4105VV2 EQZ20_17350 ENOG4106EVM EQZ20_17355 ENOG4105SFS phosphoesterase RecJ domain protein EQZ20_17370 ENOG4105U3E Transcriptional regulator EQZ20_17375 ENOG4105E8R UPF0173 metal-dependent hydrolase EQZ20_17385 ENOG4105CH7 arginosuccinase EQZ20_17390 ENOG4105CDH Citrulline--aspartate ligase EQZ20_17395 ENOG4105EPU Molybdenum cofactor synthesis domain protein EQZ20_17400 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EQZ20_17410 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EQZ20_17415 ENOG4105KBJ sporulation protein ytfj EQZ20_17430 ENOG4105VK3 rdd domain containing protein EQZ20_17435 ENOG4105D07 Signal peptide peptidase, SppA EQZ20_17450 ENOG4105C57 major facilitator superfamily EQZ20_17455 ENOG4105FS7 Transcriptional regulator EQZ20_17460 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EQZ20_17470 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EQZ20_17495 ENOG4105U5Y Transcriptional regulator EQZ20_17505 ENOG4105BZU Histidine kinase EQZ20_17510 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EQZ20_17525 ENOG4108QY0 Membrane EQZ20_17535 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein EQZ20_17565 ENOG41068G1 EQZ20_17575 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EQZ20_17595 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EQZ20_17605 ENOG4105F1V Acetoin utilization protein EQZ20_17610 ENOG4105W87 Cbs domain EQZ20_17615 ENOG4105DGU Histone deacetylase EQZ20_17625 ENOG4105ER2 Ompa motb domain protein EQZ20_17630 ENOG4107R0U MotA TolQ exbB proton channel EQZ20_17635 ENOG4105ETE Transcriptional regulator (LacI family EQZ20_17640 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EQZ20_17660 ENOG4105DFU Cell wall formation (By similarity) EQZ20_17670 ENOG4108VDD TRNA binding domain protein EQZ20_17685 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ EQZ20_17700 ENOG4105C6K Malic enzyme EQZ20_17705 ENOG4105C8F Beta-lactamase domain protein EQZ20_17710 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EQZ20_17720 ENOG4108V15 phosphotransferase enzyme family EQZ20_17735 ENOG4107F58 2'-5' rna ligase EQZ20_17740 ENOG4105C6T cysteine synthase EQZ20_17750 ENOG4107QSE Dipeptidase EQZ20_17755 ENOG4105C7N Xanthine uracil vitamin C permease EQZ20_17760 ENOG4105YW5 deoR family transcriptional regulator EQZ20_17775 ENOG4105CBX hi0933 family EQZ20_17785 ENOG4105E98 transcriptional regulator DeoR family EQZ20_17790 ENOG4105G63 Type III effector Hrp-dependent EQZ20_17795 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EQZ20_17810 ENOG4107QPK )-transporter EQZ20_17815 ENOG41085GJ domain protein EQZ20_17830 ENOG4105MU9 integral membrane protein EQZ20_17835 ENOG4105DDC Oxidoreductase domain protein EQZ20_17845 ENOG4105F5H Glycosyl Hydrolase Family 88 EQZ20_17855 ENOG41075H3 AraC family transcriptional regulator EQZ20_17865 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EQZ20_17875 ENOG4105NTD Inherit from COG: Hydrolase EQZ20_17885 ENOG4107V2S Transcriptional regulator EQZ20_17890 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase EQZ20_17895 ENOG4105C8T Leucyl-tRNA synthetase EQZ20_17905 ENOG410605W Major Facilitator EQZ20_17915 ENOG4105D01 (LipO)protein EQZ20_17920 ENOG4106UBQ EQZ20_17925 ENOG4107R34 abc transporter permease protein EQZ20_17930 ENOG4105C19 ABC transporter EQZ20_17940 ENOG4105DVE abc transporter atp-binding protein EQZ20_17945 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EQZ20_17955 ENOG4105N5T Radical SAM Protein EQZ20_17975 ENOG4105E8V Alpha Beta Hydrolase Fold protein EQZ20_17980 ENOG4108Z0R Transferase EQZ20_17985 ENOG4105YVM Phosphoesterase, PA-phosphatase related EQZ20_18005 ENOG4105CAQ asparagine synthetase EQZ20_18010 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EQZ20_18030 ENOG4105D2X ABC transporter substrate-binding protein EQZ20_18040 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EQZ20_18065 ENOG4108RMU ferritin dps family protein EQZ20_18080 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) EQZ20_18085 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EQZ20_18090 ENOG4108V2W Carbonate dehydratase EQZ20_18095 ENOG4105DSE periplasmic solute binding protein EQZ20_18130 ENOG4108PGP mmge prpd family protein EQZ20_18135 ENOG4105CH2 amidohydrolase EQZ20_18145 ENOG4108HW4 amino acid AbC transporter EQZ20_18150 ENOG4105EAB amino acid AbC transporter EQZ20_18155 ENOG4108XSB acetyltransferase, (GNAT) family EQZ20_18160 ENOG4105CPU Monooxygenase EQZ20_18165 ENOG4105DTQ mandelate racemase muconate lactonizing EQZ20_18170 ENOG4105CEY Amp-dependent synthetase and ligase EQZ20_18175 ENOG4108IPT Naphthoate synthase EQZ20_18180 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EQZ20_18185 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) EQZ20_18190 ENOG4105E4F Isochorismate synthase EQZ20_18195 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EQZ20_18345 ENOG4105CMD Transcriptional regulator, GntR family EQZ20_18350 ENOG4105N67 Proton-coupled thiamine transporter YuaJ EQZ20_18375 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) EQZ20_18380 ENOG4106DF1 EQZ20_18385 ENOG4108VNY MOSC domain protein EQZ20_18390 ENOG4108JB8 alcohol dehydrogenase EQZ20_18395 ENOG4105C26 Dehydrogenase EQZ20_18400 ENOG4105TRT Transcriptional regulator EQZ20_18405 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EQZ20_18410 ENOG4107ZTW SNARE associated Golgi EQZ20_18500 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) EQZ20_18525 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EQZ20_18535 ENOG4105EE0 oxidoreductase EQZ20_18545 ENOG4105C8Q Methyl-accepting chemotaxis EQZ20_18550 ENOG4105C8Q Methyl-accepting chemotaxis EQZ20_18555 ENOG4105C8Q Methyl-accepting chemotaxis EQZ20_18570 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EQZ20_18585 ENOG4105C37 (CBS) domain EQZ20_18600 ENOG4107PBV potassium channel EQZ20_18605 ENOG4107PBV potassium channel EQZ20_18615 ENOG410900G Protein of unknown function (DUF421) EQZ20_18620 ENOG4107QYV phosphohexose isomerase EQZ20_18625 ENOG4107QW4 alcohol dehydrogenase EQZ20_18630 ENOG4105WG9 Conserved Protein EQZ20_18640 ENOG4105CHM Aminotransferase EQZ20_18645 ENOG4108ZB6 transcriptional regulator AsnC family EQZ20_18650 ENOG4108MUZ hydrolase EQZ20_18660 ENOG4105C87 Aminotransferase class I and II EQZ20_18670 ENOG4105Y38 Kinase-associated protein B EQZ20_18685 ENOG4105BZ4 penicillin-binding protein EQZ20_18690 ENOG4105KIR Thiol-disulfide oxidoreductase dcc EQZ20_18710 ENOG4108MRH transcriptional regulatory protein EQZ20_18715 ENOG4105DIH basic membrane EQZ20_18720 ENOG4108JQ9 ABC transporter EQZ20_18725 ENOG4105UIB (ABC) transporter EQZ20_18735 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EQZ20_18740 ENOG4107ZTW SNARE associated Golgi EQZ20_18745 ENOG4105DJ4 phosphatidylserine decarboxylase EQZ20_18760 ENOG4105D65 subunit l EQZ20_18765 ENOG4105HC0 Na H antiporter EQZ20_18770 ENOG4108ZE9 Monovalent cation H antiporter subunit C EQZ20_18775 ENOG4108JPZ Monovalent cation H antiporter subunit D EQZ20_18780 ENOG4105SC1 monovalent cation H antiporter subunit E EQZ20_18790 ENOG4105KJM monovalent cation h antiporter subunit g EQZ20_18795 ENOG4105KA0 thioesterase Superfamily protein EQZ20_18805 ENOG4105BZU Histidine kinase EQZ20_18830 ENOG4105D58 Diguanylate phosphodiesterase EQZ20_18835 ENOG4105DAP Nicotinate phosphoribosyltransferase EQZ20_18860 ENOG4105C02 permease EQZ20_18865 ENOG4108Z40 Transcriptional regulator EQZ20_18885 ENOG410904N short-chain dehydrogenase reductase EQZ20_18925 ENOG4108K8K Transcriptional regulator EQZ20_18930 ENOG4105DCF alanine dehydrogenase EQZ20_18955 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EQZ20_18965 ENOG41069ER domain protein EQZ20_18975 ENOG4105CEP NADH dehydrogenase EQZ20_18980 ENOG4105CAY ferredoxin--nadp reductase EQZ20_19000 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EQZ20_19035 ENOG4105PY6 Phenolic acid decarboxylase EQZ20_19050 ENOG41083MR nifu domain-containing protein EQZ20_19055 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein EQZ20_19060 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EQZ20_19065 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) EQZ20_19070 ENOG4105D6E homoserine dehydrogenase EQZ20_19075 ENOG4105C5I Dehydrogenase EQZ20_19085 ENOG4108W5N phosphatidylglycerophosphatase a EQZ20_19090 ENOG4105D4U had-superfamily hydrolase, subfamily iia EQZ20_19100 ENOG4105MMD transcriptional regulator EQZ20_19105 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) EQZ20_19110 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EQZ20_19115 ENOG4105FAA peptidase M23 EQZ20_19120 ENOG4108YTE sporulation protein YunB EQZ20_19125 ENOG4105KZD Domain of unknown function (DUF1805) EQZ20_19130 ENOG4107R8B 5'-nucleotidase EQZ20_19140 ENOG4105I3N Conserved Protein EQZ20_19145 ENOG4105IIP Membrane EQZ20_19150 ENOG4105W1N transcriptional regulator EQZ20_19160 ENOG4105C5R Aminotransferase EQZ20_19170 ENOG4105G9B Transcriptional regulator EQZ20_19195 ENOG4108K8S endonuclease I EQZ20_19200 ENOG4108IJ9 (ABC) transporter EQZ20_19205 ENOG4105FDP GntR family transcriptional regulator EQZ20_19210 ENOG4108KPW sugar kinase EQZ20_19215 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EQZ20_19220 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EQZ20_19225 ENOG4105XN3 extracellular solute-binding protein family 1 EQZ20_19230 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine EQZ20_19255 ENOG4105XRQ Xanthine dehydrogenase accessory factor EQZ20_19260 ENOG4107VFR oxidoreductase EQZ20_19305 ENOG4107EV6 Inherit from COG: YD repeat protein EQZ20_19340 ENOG41068G1 EQZ20_19350 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EQZ20_19360 ENOG4108FKH Transglycosylase SLT domain EQZ20_19405 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQZ20_19420 ENOG4105CAR Terminase, large subunit EQZ20_19470 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin EQZ20_19580 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQZ20_19585 ENOG4105DIW FeS assembly protein SUFB EQZ20_19590 ENOG4108UNV SUF system FeS assembly protein, NifU family EQZ20_19595 ENOG4105C9B Cysteine desulfurase EQZ20_19600 ENOG4105JRK feS assembly protein SufD EQZ20_19605 ENOG4105C3K feS assembly ATPase SufC EQZ20_19610 ENOG4105PGM cation diffusion facilitator family transporter EQZ20_19620 ENOG4105D01 (LipO)protein EQZ20_19625 ENOG4108UMI ABC transporter, permease EQZ20_19630 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EQZ20_19655 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EQZ20_19660 ENOG41080E8 Transcriptional regulator, Spx MgsR family EQZ20_19665 ENOG4105C1G acyl-Coa dehydrogenase EQZ20_19670 ENOG4105CHU acetyl-coa acetyltransferase EQZ20_19705 ENOG4105E0A ABC, transporter EQZ20_19710 ENOG4108IHU transport system permease protein EQZ20_19715 ENOG4105DQ5 transport system permease protein EQZ20_19720 ENOG4108MES Periplasmic binding protein EQZ20_19735 ENOG4105DZ1 carboxypeptidase EQZ20_19740 ENOG4105E1F short-chain dehydrogenase reductase EQZ20_19745 ENOG4105HUF DNA protection during starvation protein EQZ20_19755 ENOG4105C0H protease EQZ20_19765 ENOG4105F3H Histidine kinase EQZ20_19770 ENOG41067SE Tetr family transcriptional regulator EQZ20_19775 ENOG4105C9Q fumarate hydratase class II EQZ20_19805 ENOG4105WH1 Two component transcriptional regulator luxr family EQZ20_19810 ENOG4105ENE Histidine kinase EQZ20_19825 ENOG41087YS Phage shock protein A EQZ20_19845 ENOG4108WBT adenosyltransferase EQZ20_19850 ENOG4105E0A ABC, transporter EQZ20_19855 ENOG4105EHG Permease protein EQZ20_19860 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EQZ20_19865 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EQZ20_19870 ENOG4108RPX mosc domain containing protein EQZ20_19875 ENOG4107RSM transcriptional regulator EQZ20_19885 ENOG4105CTX dehydratase EQZ20_19890 ENOG4107QZW Altronate oxidoreductase EQZ20_19895 ENOG4107KJX Transcriptional regulator EQZ20_19900 ENOG4105CT4 transporter EQZ20_19905 ENOG4105D2H Uronic isomerase EQZ20_19915 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQZ20_19920 ENOG4105E0A ABC, transporter EQZ20_19925 ENOG4105EHG Permease protein EQZ20_19930 ENOG4105DQ5 transport system permease protein EQZ20_19935 ENOG4105D5Q Arginine ornithine antiporter EQZ20_19950 ENOG4107QZ2 Sulfatase EQZ20_19965 ENOG4105EVU fructokinase EQZ20_19970 ENOG4105EEQ Na H antiporter EQZ20_19975 ENOG4107EPV Aminotransferase class V EQZ20_19985 ENOG4105EEM helicase EQZ20_19990 ENOG4105EN6 Membrane EQZ20_19995 ENOG4105RHY Pfam:UPF0157 EQZ20_20000 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EQZ20_20010 ENOG4107ZQN disulfide bond EQZ20_20015 ENOG4105C59 p-type ATPase EQZ20_20030 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EQZ20_20035 ENOG4105CJQ hydrolase, family 31 EQZ20_20045 ENOG4105DIK (ABC) transporter EQZ20_20050 ENOG4105CC5 ABC transporter EQZ20_20055 ENOG4105DSE periplasmic solute binding protein EQZ20_20060 ENOG4105HX0 Transcriptional regulator EQZ20_20065 ENOG4105DE4 1-phosphofructokinase EQZ20_20070 ENOG4105DM4 PTS System EQZ20_20075 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN EQZ20_20080 ENOG4105D2N Aldolase EQZ20_20085 ENOG4105C59 p-type ATPase EQZ20_20090 ENOG410681U heavy metal transport detoxification protein EQZ20_20095 ENOG4105VPX protein, conserved in bacteria EQZ20_20100 ENOG4108Z0Z intracellular protease Pfpi family EQZ20_20105 ENOG4105E98 transcriptional regulator DeoR family EQZ20_20110 ENOG4105DET Rhamnulokinase EQZ20_20115 ENOG4105C9F isomerase EQZ20_20130 ENOG4105F27 Major Facilitator EQZ20_20150 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EQZ20_20160 ENOG4105D9R oxidoreductase EQZ20_20170 ENOG4105C72 UPF0176 protein EQZ20_20180 ENOG4106DF4 Sigma-70, region 4 EQZ20_20190 ENOG4105F0F Oxalate decarboxylase EQZ20_20210 ENOG4107SYN Glycosyl hydrolases family 43 EQZ20_20220 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EQZ20_20245 ENOG41068G1 EQZ20_20265 ENOG4108FKH Transglycosylase SLT domain EQZ20_20355 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin EQZ20_20430 ENOG4105WXW Antirepressor EQZ20_20445 ENOG4108IMY Transcriptional regulator EQZ20_20455 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) EQZ20_20465 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EQZ20_20470 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EQZ20_20480 ENOG4105XZU Preprotein translocase, subunit SecG EQZ20_20505 ENOG4105R40 Glycine betaine carnitine choline EQZ20_20510 ENOG4108HQR Glycine betaine EQZ20_20515 ENOG4105E90 ABC transporter EQZ20_20520 ENOG4108IJ8 ABC transporter EQZ20_20525 ENOG4107HG4 Transcriptional regulator EQZ20_20535 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EQZ20_20550 ENOG4105T65 Membrane-associated protein EQZ20_20555 ENOG4108MES Periplasmic binding protein EQZ20_20565 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EQZ20_20570 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EQZ20_20575 ENOG4105CP7 Triose-phosphate isomerase EQZ20_20580 ENOG4105BZA Phosphoglycerate kinase EQZ20_20585 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EQZ20_20595 ENOG4105DEN Luciferase family EQZ20_20625 ENOG4105BZU Histidine kinase EQZ20_20630 ENOG4105WH1 Two component transcriptional regulator luxr family EQZ20_20645 ENOG4105CIG ABC transporter EQZ20_20655 ENOG4108Z5V transcriptional regulator, merr family EQZ20_20675 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EQZ20_20680 ENOG4105JXH GntR family transcriptional regulator EQZ20_20685 ENOG4105DAA L-lactate EQZ20_20690 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQZ20_20700 ENOG4108ZPC Polysaccharide pyruvyl transferase EQZ20_20705 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EQZ20_20710 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family EQZ20_20715 ENOG4105D3Q Sugar transferase EQZ20_20725 ENOG4105K64 Glycosyl transferase, family 2 EQZ20_20735 ENOG4107QRS glycosyltransferase group 2 family protein EQZ20_20740 ENOG41068W6 Capsular polysaccharide biosynthesis protein EQZ20_20745 ENOG4108KMV Glycosyl transferase (Group 1 EQZ20_20750 ENOG4105K64 Glycosyl transferase, family 2 EQZ20_20755 ENOG4108PQP glycosyl transferase group 1 EQZ20_20765 ENOG4108QV3 biosynthesis protein EQZ20_20770 ENOG4105HTX biosynthesis protein EQZ20_20780 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EQZ20_20785 ENOG4108I5G Major Facilitator superfamily EQZ20_20795 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EQZ20_20800 ENOG4107S2N Type III effector Hrp-dependent EQZ20_20805 ENOG4105C0A alcohol dehydrogenase EQZ20_20810 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQZ20_20820 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQZ20_20835 ENOG4105EDQ levansucrase EC 2.4.1.10 EQZ20_20840 ENOG4108HKT sucrose-6-phosphate hydrolase EQZ20_20845 ENOG4106ANW SMI1_KNR4 EQZ20_20875 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase EQZ20_20895 ENOG41068G1 EQZ20_21090 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) EQZ20_21100 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EQZ20_21125 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQZ20_21130 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EQZ20_21165 ENOG4105C2M dna polymerase I EQZ20_21220 ENOG4105WXW Antirepressor EQZ20_21285 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQZ20_21295 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQZ20_21305 ENOG4108URH decarboxylase EQZ20_21310 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain EQZ20_21315 ENOG4107TVP HD domain protein EQZ20_21330 ENOG4105C5I Dehydrogenase EQZ20_21335 ENOG4108SQ9 flavin reductase domain protein, FMN-binding EQZ20_21340 ENOG4108ZHR arsR family transcriptional regulator EQZ20_21350 ENOG4105C19 ABC transporter EQZ20_21355 ENOG4105EWM Histidine kinase EQZ20_21365 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase EQZ20_21370 ENOG4105KRI phosphocarrier protein (HPr EQZ20_21375 ENOG4105CIE May be required for sporulation (By similarity) EQZ20_21380 ENOG4105CHW UPF0052 protein EQZ20_21385 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EQZ20_21390 ENOG4108Z4K mutator MutT protein EQZ20_21400 ENOG4105C3M thioredoxin reductase EQZ20_21415 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EQZ20_21420 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EQZ20_21425 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EQZ20_21430 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EQZ20_21435 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EQZ20_21440 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EQZ20_21445 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EQZ20_21450 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) EQZ20_21465 ENOG4108E16 pectate lyase EQZ20_21470 ENOG4108S4C acetyltransferase EQZ20_21475 ENOG4107XGZ Hydrolase EQZ20_21480 ENOG4105HKU nucleoside recognition domain-containing protein EQZ20_21490 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) EQZ20_21495 ENOG410834F Transcriptional regulator EQZ20_21500 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQZ20_21505 ENOG41088CQ domain protein EQZ20_21510 ENOG41086DT Membrane protein of unknown function EQZ20_21515 ENOG41067S9 phage shock protein C, PspC EQZ20_21520 ENOG4108PY7 EQZ20_21535 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EQZ20_21540 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EQZ20_21565 ENOG4105CN1 protease EQZ20_21570 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EQZ20_21580 ENOG4105CRP Part of the ABC transporter FtsEX involved in EQZ20_21585 ENOG4105CAK Cell division ATP-binding protein ftsE EQZ20_21605 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EQZ20_21610 ENOG4105MS2 ribosomal subunit Interface protein EQZ20_21625 ENOG4105MQ3 flagellar protein FliS EQZ20_21630 ENOG4107RT6 flagellar hook-associated EQZ20_21635 ENOG41083S7 flagellar protein FlaG EQZ20_21640 ENOG4105I03 Flagellin EQZ20_21645 ENOG4105I03 Flagellin EQZ20_21650 ENOG4105I03 Flagellin EQZ20_21655 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EQZ20_21660 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) EQZ20_21665 ENOG4105MKD EQZ20_21670 ENOG4105DTJ flagellar hook-associated protein EQZ20_21675 ENOG4105E1Q flagellar hook-associated protein EQZ20_21690 ENOG4105RU3 EQZ20_21715 ENOG4105WH1 Two component transcriptional regulator luxr family EQZ20_21720 ENOG4105BZU Histidine kinase EQZ20_21725 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EQZ20_21730 ENOG4108KGH TRANSCRIPTIONal EQZ20_21735 ENOG4105ESV Glycosyl transferase, family 4 EQZ20_21740 ENOG4107EF8 Glycosyl transferase (Group 1 EQZ20_21755 ENOG4105QZI O-Antigen Polymerase EQZ20_21760 ENOG4105C1B dTDP-glucose 4-6-dehydratase EQZ20_21765 ENOG4105C6Y Udp-glucose 6-dehydrogenase EQZ20_21770 ENOG4107RA4 Glycosyl transferase (Group 1 EQZ20_21775 ENOG4105PSV Polysaccharide Biosynthesis Protein EQZ20_21780 ENOG4105D3Q Sugar transferase EQZ20_21785 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQZ20_21790 ENOG4105JFG SpoIID LytB domain protein EQZ20_21800 ENOG4108KGH TRANSCRIPTIONal EQZ20_21805 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EQZ20_21810 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EQZ20_21815 ENOG4105EY8 ABC transporter EQZ20_21840 ENOG4107SJB teichoic acid biosynthesis EQZ20_21850 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase EQZ20_21860 ENOG4107RZX Teichoic acid biosynthesis protein EQZ20_21870 ENOG4105DG6 mannose-6-phosphate isomerase EQZ20_21880 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase EQZ20_21885 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) EQZ20_21890 ENOG4108UHU Aldolase EQZ20_21895 ENOG4105D7K pfkb domain protein EQZ20_21900 ENOG4108M60 Transcriptional regulator EQZ20_21910 ENOG4105CHR reductase EQZ20_21920 ENOG4105C54 Major Facilitator superfamily EQZ20_21925 ENOG4108KGH TRANSCRIPTIONal EQZ20_21930 ENOG4105J7I hydrolase EQZ20_21935 ENOG4105K4H Nlp p60 protein EQZ20_21940 ENOG4105PNM synthesis protein EQZ20_21950 ENOG4105N98 Capsule biosynthesis protein capB EQZ20_21955 ENOG4105ETE Transcriptional regulator (LacI family EQZ20_21960 ENOG4108RVA ribokinase EQZ20_21965 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EQZ20_21970 ENOG4105C2J ABC transporter EQZ20_21975 ENOG4105CNN ABC, transporter EQZ20_21980 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EQZ20_21985 ENOG4105C5Q Transcriptional regulator EQZ20_21990 ENOG41089UC methyltransferase, type 11 EQZ20_21995 ENOG4107FQX Alpha-acetolactate decarboxylase EQZ20_22005 ENOG4107RSM transcriptional regulator EQZ20_22025 ENOG4105CAH Chromate EQZ20_22030 ENOG4105FGV Chromate EQZ20_22035 ENOG4105C6Y Udp-glucose 6-dehydrogenase EQZ20_22040 ENOG4108RB3 Capsular polysaccharide biosynthesis protein EQZ20_22045 ENOG4105HTX biosynthesis protein EQZ20_22055 ENOG4105KBK Zinc finger, swim domain protein EQZ20_22060 ENOG4105C0D helicase EQZ20_22065 ENOG4108YZ9 Urea amidohydrolase subunit gamma EQZ20_22070 ENOG4105KI2 Urea amidohydrolase subunit beta EQZ20_22080 ENOG410667J hydrolase EQZ20_22085 ENOG4105E98 transcriptional regulator DeoR family EQZ20_22095 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase EQZ20_22100 ENOG4105VI0 Pts system, glucitol sorbitol-specific EQZ20_22105 ENOG4105DZY Pts system, glucitol sorbitol-specific EQZ20_22110 ENOG410787A Pts system, glucitol sorbitol-specific EQZ20_22120 ENOG4105DKT Transcriptional regulator EQZ20_22125 ENOG4105Z8H single-stranded DNA-binding protein EQZ20_22145 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EQZ20_22150 ENOG4105CGA flagellar basal-body rod protein FlgG EQZ20_22160 ENOG4105DFF Rod shape-determining protein mreb EQZ20_22165 ENOG4105MT0 Sporulation transcriptional regulator spoiiid EQZ20_22175 ENOG4107MII Sugar-specific transcriptional regulator TrmB EQZ20_22180 ENOG4105CZM Major Facilitator EQZ20_22185 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EQZ20_22195 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase EQZ20_22205 ENOG4108NA0 Uncharacterized conserved protein (COG2071) EQZ20_22210 ENOG41080XP Cbs domain EQZ20_22220 ENOG4105C37 (CBS) domain EQZ20_22225 ENOG4105BZU Histidine kinase EQZ20_22245 ENOG4105FRN stage II sporulation protein EQZ20_22250 ENOG4107TCE N-acetyltransferase EQZ20_22260 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EQZ20_22265 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQZ20_22270 ENOG4105WQT MbtH domain protein EQZ20_22275 ENOG4105CEY Amp-dependent synthetase and ligase EQZ20_22280 ENOG4105WQI isochorismatase EQZ20_22285 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EQZ20_22290 ENOG4105E4F Isochorismate synthase EQZ20_22295 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EQZ20_22300 ENOG4105NIV Esterase EQZ20_22320 ENOG410874W AraC family transcriptional regulator EQZ20_22325 ENOG4106BRK EQZ20_22330 ENOG4108RYK Nad-dependent epimerase dehydratase EQZ20_22335 ENOG4108Z40 Transcriptional regulator EQZ20_22350 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EQZ20_22355 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EQZ20_22360 ENOG4105FCD Major Facilitator EQZ20_22365 ENOG4108J2R molybdopterin oxidoreductase EQZ20_22370 ENOG4108TF4 von Willebrand factor, type A EQZ20_22385 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EQZ20_22395 ENOG4106778 Protein of unknown function (DUF1146) EQZ20_22400 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EQZ20_22405 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EQZ20_22410 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EQZ20_22415 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EQZ20_22420 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EQZ20_22435 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) EQZ20_22450 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EQZ20_22455 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EQZ20_22460 ENOG4108UIC UPF0340 protein EQZ20_22465 ENOG4108YZG isomerase EQZ20_22470 ENOG4107WAU Protein tyrosine phosphatase EQZ20_22475 ENOG410815N Probably functions as a manganese efflux pump (By similarity) EQZ20_22480 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EQZ20_22490 ENOG4108ZXQ stage ii sporulation protein r EQZ20_22505 ENOG4105TRI Hydrolase EQZ20_22520 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EQZ20_22525 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EQZ20_22530 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EQZ20_22540 ENOG4107TT2 Auxin Efflux Carrier EQZ20_22545 ENOG4105C6K Malic enzyme EQZ20_22550 ENOG4107104 thymidine kinase EQZ20_22555 ENOG41082DI 50s ribosomal protein l31 EQZ20_22560 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EQZ20_22565 ENOG4105CBT Fructose-1,6-bisphosphatase EQZ20_22570 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EQZ20_22575 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway EQZ20_22580 ENOG4105D2N Aldolase EQZ20_22585 ENOG410812K response regulator receiver protein EQZ20_22595 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EQZ20_22610 ENOG4105C1G acyl-Coa dehydrogenase EQZ20_22615 ENOG4105C1G acyl-Coa dehydrogenase EQZ20_22620 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EQZ20_22630 ENOG4105DF6 Fe-S oxidoreductase EQZ20_22640 ENOG4105C75 arginyL-tRNA synthetase EQZ20_22645 ENOG410684U Domain of unknown function (DUF1934) EQZ20_22650 ENOG4105CYW agmatinase EQZ20_22655 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EQZ20_22660 ENOG4105BZ4 penicillin-binding protein EQZ20_22665 ENOG4108XFG YwhD family EQZ20_22670 ENOG4108Z4T Peptidase M50 EQZ20_22675 ENOG41069HH 4-oxalocrotonate tautomerase EQZ20_22690 ENOG4105DCI Phosphohydrolase EQZ20_22700 ENOG4108VCI transcription factor, rsfa family EQZ20_22715 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) EQZ20_22725 ENOG4105D2S major facilitator superfamily EQZ20_22750 ENOG4108FUF Transcriptional regulator, IclR family EQZ20_22760 ENOG4108IJ2 phosphate acetyltransferase EQZ20_22765 ENOG4107JTW chlorite dismutase EQZ20_22775 ENOG4105CZN Potassium uptake protein EQZ20_22800 ENOG4105CJ1 ABC, transporter EQZ20_22810 ENOG4105WH1 Two component transcriptional regulator luxr family EQZ20_22830 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EQZ20_22835 ENOG4108RJ9 Glycosyl transferase, family 2 EQZ20_22840 ENOG4105DWF phosphomethylpyrimidine kinase EQZ20_22855 ENOG4105C5Y PTS System EQZ20_22870 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin EQZ20_22880 ENOG4105DEN Luciferase family EQZ20_22885 ENOG4108DBC nitroreductase EQZ20_22905 ENOG4105DWD nucleoside recognition domain protein EQZ20_22920 ENOG41060D1 Quinol oxidase EQZ20_22930 ENOG4105BZ9 Cytochrome C oxidase, subunit I EQZ20_22935 ENOG4105E2S oxidase) subunit II EQZ20_22940 ENOG4105CMR udp-glucose 4-epimerase EQZ20_22950 ENOG4108WS4 fmn reductase EQZ20_22965 ENOG4105CMG Carbohydrate kinase EQZ20_22970 ENOG4105C93 Xylose Isomerase EQZ20_22980 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EQZ20_22985 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase EQZ20_22990 ENOG4105CMU LysR family (Transcriptional regulator EQZ20_23010 ENOG41067MG lrgb family EQZ20_23015 ENOG4105CK7 Sodium proline symporter EQZ20_23020 ENOG4105DR4 Methyltransferase EQZ20_23030 ENOG4105C5I Dehydrogenase EQZ20_23035 ENOG4105X1N Glycosyl transferase family 8 EQZ20_23045 ENOG4105DJB Major Facilitator Superfamily EQZ20_23050 ENOG4105CXK mandelate racemase muconate lactonizing EQZ20_23055 ENOG4108UHU Aldolase EQZ20_23060 ENOG4105D7K pfkb domain protein EQZ20_23065 ENOG4105J4Q Transcriptional regulator EQZ20_23070 ENOG4105IIU Aminopeptidase EQZ20_23100 ENOG41080V3 Major Facilitator superfamily EQZ20_23105 ENOG4105D3W isochorismatase EQZ20_23130 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) EQZ20_23135 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EQZ20_23140 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) EQZ20_23145 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EQZ20_23150 ENOG4105CM2 brancheD-chain amino acid aminotransferase EQZ20_23160 ENOG4105F8D glycoside hydrolase family 4 EQZ20_23165 ENOG4105VCP PTS System EQZ20_23170 ENOG4105CK1 PTS System EQZ20_23175 ENOG4105VZJ PTS System EQZ20_23180 ENOG4105EMD TRANSCRIPTIONal EQZ20_23185 ENOG4108VX5 3-methyladenine DNA glycosylase EQZ20_23190 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EQZ20_23195 ENOG4105C5E polysaccharide biosynthesis protein EQZ20_23215 ENOG4105DXD 2-methylcitrate dehydratase EQZ20_23220 ENOG4105CR4 methylisocitrate lyase EQZ20_23225 ENOG4105BZ1 (ABC) transporter EQZ20_23230 ENOG4107TDE lipolytic protein G-D-S-L family EQZ20_23255 ENOG4105DA5 (ABC) transporter EQZ20_23305 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EQZ20_23310 ENOG4108J20 pectate lyase EQZ20_23315 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EQZ20_23325 ENOG4108JJ8 (ABC) transporter EQZ20_23330 ENOG4108JJ9 ABC, transporter EQZ20_23335 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EQZ20_23340 ENOG4105C4M (Ubiquinol oxidase) subunit I EQZ20_23350 ENOG4108QTI )-transporter EQZ20_23365 ENOG4105DFD Na H antiporter EQZ20_23370 ENOG4108IJ0 Aspartate ammonia-lyase EQZ20_23375 ENOG4105HDK L-asparaginase EQZ20_23380 ENOG4108IMY Transcriptional regulator EQZ20_23385 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EQZ20_23425 ENOG4107BJW polysaccharide deacetylase EQZ20_23435 ENOG4105D2K citrate carrier protein EQZ20_23440 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EQZ20_23445 ENOG4105X3H Excalibur domain protein EQZ20_23470 ENOG4105E0M Sulfatase EQZ20_23490 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EQZ20_23495 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EQZ20_23505 ENOG4105CEU Arginine dihydrolase EQZ20_23510 ENOG4105DBV ornithine carbamoyltransferase EQZ20_23520 ENOG4105C5B carbamate kinase EQZ20_23545 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQZ20_23555 ENOG4105CS2 ec 3.2.1.21 EQZ20_23560 ENOG4105CK1 PTS System EQZ20_23570 ENOG4105JVQ RNA Polymerase EQZ20_23580 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EQZ20_23590 ENOG4107R3K hydrolase EQZ20_23595 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) EQZ20_23600 ENOG4105ETE Transcriptional regulator (LacI family EQZ20_23615 ENOG4105FB2 class II Aldolase EQZ20_23625 ENOG4105DT3 PTS system, galactitol-specific IIc component EQZ20_23630 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EQZ20_23655 ENOG4105EDW glycosyl transferase, family 39 EQZ20_23660 ENOG4105CKK Glycosyl transferase, family 2 EQZ20_23665 ENOG4105CMR udp-glucose 4-epimerase EQZ20_23675 ENOG4105CH6 catalase EQZ20_23680 ENOG4105D4T Citrate transporter EQZ20_23685 ENOG4105CS2 ec 3.2.1.21 EQZ20_23690 ENOG4105C5Y PTS System EQZ20_23695 ENOG4105CID antiterminator EQZ20_23700 ENOG4108W7F transporter, permease EQZ20_23705 ENOG4108JJB ABC transporter EQZ20_23710 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein EQZ20_23715 ENOG4105ETU transcriptional activator (TenA EQZ20_23730 ENOG4107QP3 malate synthase g EQZ20_23740 ENOG4105EDW glycosyl transferase, family 39 EQZ20_23745 ENOG4105CS2 ec 3.2.1.21 EQZ20_23750 ENOG4105C5Y PTS System EQZ20_23760 ENOG4107QHE Choloylglycine hydrolase EQZ20_23765 ENOG4106Z5D Glycoside Hydrolase Family 43 EQZ20_23770 ENOG4105C1J atp-dependent rna helicase EQZ20_23780 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EQZ20_23785 ENOG4105D9N nucleoside EQZ20_23790 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EQZ20_23795 ENOG4107RHR regulatoR EQZ20_23815 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) EQZ20_23820 ENOG4107R8N Glycosyl transferase, family 2 EQZ20_23830 ENOG4105JKW Valine--pyruvate aminotransferase EQZ20_23855 ENOG4105D2N Aldolase EQZ20_23860 ENOG4107TRN Xylose isomerase domain protein TIM barrel EQZ20_23865 ENOG4105F0H myo-inositol catabolism protein EQZ20_23870 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EQZ20_23880 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EQZ20_23885 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) EQZ20_23890 ENOG4105D7K pfkb domain protein EQZ20_23895 ENOG4105DH8 myo-inositol catabolism EQZ20_23900 ENOG4105C26 Dehydrogenase EQZ20_23910 ENOG4105CPC Aldo Keto reductase EQZ20_23920 ENOG4105CXY transporter EQZ20_23925 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EQZ20_23930 ENOG4105C5H ABC transporter EQZ20_23935 ENOG410667J hydrolase EQZ20_23945 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) EQZ20_23955 ENOG4108V5C ABC transporter EQZ20_23975 ENOG4105H93 Acyltransferase family EQZ20_24020 ENOG4105EG2 ABC transporter, permease EQZ20_24030 ENOG4107FKK extracellular solute-binding protein family 1 EQZ20_24040 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) EQZ20_24045 ENOG4105CMR udp-glucose 4-epimerase EQZ20_24050 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase EQZ20_24055 ENOG4105E2R ROK family EQZ20_24060 ENOG4105G3Z GntR family transcriptional regulator EQZ20_24065 ENOG4105CMG Carbohydrate kinase EQZ20_24070 ENOG4105C6Z Gluconate EQZ20_24075 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EQZ20_24080 ENOG4108EKI Dehydrogenase EQZ20_24090 ENOG4105D3R alkyl hydroperoxide reductase EQZ20_24095 ENOG4108JU3 Alkyl hydroperoxide reductase EQZ20_24100 ENOG4105CS2 ec 3.2.1.21 EQZ20_24110 ENOG4108S3Y transcriptional regulator EQZ20_24125 ENOG4108M15 ABC transporter EQZ20_24130 ENOG4105KCT ABC transporter EQZ20_24135 ENOG4105BZU Histidine kinase EQZ20_24155 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EQZ20_24170 ENOG4105WQG acetyltransferase EQZ20_24185 ENOG4105C0H protease EQZ20_24190 ENOG4105Q2H domain protein EQZ20_24205 ENOG4105BZU Histidine kinase EQZ20_24210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQZ20_24235 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EQZ20_24245 ENOG4105CDU Replicative dna helicase EQZ20_24260 ENOG4105DJ2 Major Facilitator Superfamily EQZ20_24265 ENOG4105CE4 GlcNAc 6-P deacetylase EQZ20_24270 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EQZ20_24275 ENOG4105FDP GntR family transcriptional regulator EQZ20_24280 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EQZ20_24290 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EQZ20_24295 ENOG4105BZR domain protein EQZ20_24300 ENOG4108XMW Membrane EQZ20_24310 ENOG4105CHH sulfate transporter EQZ20_24320 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EQZ20_24325 ENOG4108UUM single-stranded DNA-binding protein EQZ20_24330 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EQZ20_24335 ENOG4105C3G gtp-binding protein EQZ20_24340 ENOG4105VDK protein, conserved in bacteria EQZ20_24350 ENOG4108ZDA Sporulation protein YyaC EQZ20_24355 ENOG4105FA0 parb-like partition protein EQZ20_24360 ENOG4107QJE Chromosome Partitioning Protein EQZ20_24365 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EQZ20_24370 ENOG4108KPJ rna polymerase sigma factor EQZ20_24375 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) EQZ20_24385 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EQZ20_24390 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EQZ20_24405 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)