locus-tag	class	description
O0R52_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O0R52_00010	COG0592	DNA-directed DNA polymerase activity
O0R52_00015	COG2501	S4 domain
O0R52_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O0R52_00030	COG0187	DNA topoisomerase II activity
O0R52_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O0R52_00070	COG0517	IMP dehydrogenase activity
O0R52_00070	COG0516	GMP reductase activity
O0R52_00075	COG1686	Belongs to the peptidase S11 family
O0R52_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
O0R52_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O0R52_00100	COG1428	Deoxynucleoside kinase
O0R52_00105	COG1428	Deoxynucleoside kinase
O0R52_00110	COG1388	LysM domain
O0R52_00110	COG3858	chitin binding
O0R52_00115	COG1335	isochorismatase
O0R52_00120	COG0590	tRNA wobble adenosine to inosine editing
O0R52_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O0R52_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O0R52_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O0R52_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
O0R52_00190	COG3853	Toxic anion resistance protein (TelA)
O0R52_00195	COG1982	Orn Lys Arg decarboxylase major
O0R52_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O0R52_00205	COG3870	Protein conserved in bacteria
O0R52_00210	COG1728	Protein conserved in bacteria
O0R52_00215	COG0470	DNA polymerase III
O0R52_00220	COG1774	PSP1 C-terminal conserved region
O0R52_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O0R52_00235	COG2827	Endonuclease containing a URI domain
O0R52_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O0R52_00245	COG2002	toxin-antitoxin pair type II binding
O0R52_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O0R52_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O0R52_00255	COG0084	hydrolase, TatD family'
O0R52_00260	COG3583	domain protein
O0R52_00260	COG3584	3D domain protein
O0R52_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O0R52_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O0R52_00280	COG4466	Protein conserved in bacteria
O0R52_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O0R52_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O0R52_00300	COG0251	oxidation-reduction process
O0R52_00305	COG2088	sporulation resulting in formation of a cellular spore
O0R52_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O0R52_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O0R52_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O0R52_00325	COG0193	aminoacyl-tRNA hydrolase activity
O0R52_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O0R52_00340	COG2002	toxin-antitoxin pair type II binding
O0R52_00345	COG2244	polysaccharide biosynthetic process
O0R52_00350	COG3956	TIGRFAM MazG family protein
O0R52_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
O0R52_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
O0R52_00375	COG1098	S1 RNA binding domain
O0R52_00390	COG2208	phosphoserine phosphatase activity
O0R52_00395	COG2304	oxidoreductase activity
O0R52_00400	COG0515	serine threonine protein kinase
O0R52_00405	COG0037	tRNA processing
O0R52_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
O0R52_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O0R52_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O0R52_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O0R52_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O0R52_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O0R52_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O0R52_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
O0R52_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O0R52_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O0R52_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O0R52_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O0R52_00470	COG1396	sequence-specific DNA binding
O0R52_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O0R52_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O0R52_00560	COG4463	regulation of RNA biosynthetic process
O0R52_00565	COG3880	PFAM UvrB UvrC protein
O0R52_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
O0R52_00575	COG0542	response to heat
O0R52_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O0R52_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
O0R52_00590	COG4956	integral membrane protein (PIN domain superfamily)
O0R52_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O0R52_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O0R52_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O0R52_00610	COG1045	serine acetyltransferase
O0R52_00615	COG0215	cysteine-tRNA ligase activity
O0R52_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O0R52_00630	COG3688	RNA-binding protein containing a PIN domain
O0R52_00635	COG1595	DNA-templated transcription, initiation
O0R52_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O0R52_00650	COG0250	Participates in transcription elongation, termination and antitermination
O0R52_00660	COG0081	regulation of translation
O0R52_00675	COG2813	Specifically methylates the guanine in position
O0R52_00680	COG0085	RNA polymerase activity
O0R52_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O0R52_00690	COG1358	cellular component organization or biogenesis
O0R52_00700	COG0049	tRNA binding
O0R52_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O0R52_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O0R52_00715	COG0596	Alpha beta hydrolase
O0R52_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O0R52_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O0R52_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O0R52_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O0R52_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O0R52_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O0R52_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O0R52_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O0R52_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O0R52_00820	COG0200	Binds to the 23S rRNA
O0R52_00825	COG0201	protein transport
O0R52_00830	COG0563	adenylate kinase activity
O0R52_00835	COG0024	Methionine aminopeptidase
O0R52_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O0R52_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O0R52_00865	COG0202	RNA polymerase activity
O0R52_00870	COG0203	ribosomal protein L17
O0R52_00875	COG1122	ATPase activity
O0R52_00880	COG1122	ATPase activity
O0R52_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O0R52_00890	COG0101	tRNA pseudouridine synthase activity
O0R52_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O0R52_00905	COG2226	methyltransferase
O0R52_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R52_00920	COG0489	protein tyrosine kinase activity
O0R52_00930	COG2194	sulfuric ester hydrolase activity
O0R52_00935	COG0726	polysaccharide deacetylase
O0R52_01015	COG0659	secondary active sulfate transmembrane transporter activity
O0R52_01020	COG0385	Bile acid
O0R52_01025	COG2819	hydrolase of the alpha beta superfamily
O0R52_01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R52_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R52_01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R52_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R52_01045	COG2207	Transcriptional regulator
O0R52_01050	COG3876	Protein conserved in bacteria
O0R52_01055	COG1472	Belongs to the glycosyl hydrolase 3 family
O0R52_01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O0R52_01065	COG1263	PTS System
O0R52_01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R52_01070	COG1737	Transcriptional regulator
O0R52_01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O0R52_01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R52_01085	COG1683	Conserved Protein
O0R52_01115	COG1595	DNA-templated transcription, initiation
O0R52_01120	COG5662	AntiSigma factor
O0R52_01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
O0R52_01130	COG4856	YbbR-like protein
O0R52_01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O0R52_01150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O0R52_01155	COG3002	Belongs to the UPF0753 family
O0R52_01160	COG0288	reversible hydration of carbon dioxide
O0R52_01170	COG5609	conserved protein (DUF2294)
O0R52_01175	COG0640	Transcriptional regulator
O0R52_01180	COG2814	Major facilitator Superfamily
O0R52_01200	COG0596	Alpha beta hydrolase
O0R52_01205	COG0745	RESPONSE REGULATOR receiver
O0R52_01210	COG0642	Histidine kinase
O0R52_01220	COG0515	serine threonine protein kinase
O0R52_01235	COG1113	amino acid transport
O0R52_01250	COG2602	Beta-lactamase
O0R52_01255	COG2124	cytochrome p450
O0R52_01265	COG0531	amino acid
O0R52_01270	COG0584	glycerophosphoryl diester phosphodiesterase
O0R52_01275	COG2271	Major facilitator Superfamily
O0R52_01285	COG0456	acetyltransferase
O0R52_01285	COG1846	Transcriptional regulator
O0R52_01290	COG2271	Major facilitator Superfamily
O0R52_01300	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_01310	COG0371	Dehydrogenase
O0R52_01315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
O0R52_01320	COG3591	Belongs to the peptidase S1B family
O0R52_01330	COG0596	Alpha beta hydrolase
O0R52_01335	COG1183	phosphatidylcholine synthase activity
O0R52_01340	COG0586	Pfam SNARE associated Golgi protein
O0R52_01345	COG0688	phosphatidylethanolamine metabolic process
O0R52_01355	COG2312	Erythromycin esterase
O0R52_01360	COG2207	Transcriptional regulator
O0R52_01365	COG1054	Belongs to the UPF0176 family
O0R52_01370	COG1301	dicarboxylic acid transport
O0R52_01375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R52_01375	COG1263	PTS System
O0R52_01375	COG2190	(PTS) system
O0R52_01380	COG0363	glucosamine-6-phosphate deaminase activity
O0R52_01385	COG2188	Transcriptional regulator
O0R52_01395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O0R52_01400	COG0833	amino acid
O0R52_01405	COG2040	homocysteine
O0R52_01410	COG1115	amino acid carrier protein
O0R52_01415	COG2066	Belongs to the glutaminase family
O0R52_01420	COG4191	Histidine kinase
O0R52_01425	COG0784	Response regulator, receiver
O0R52_01430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O0R52_01435	COG1012	belongs to the aldehyde dehydrogenase family
O0R52_01440	COG2271	Major facilitator Superfamily
O0R52_01445	COG4948	Mandelate Racemase Muconate Lactonizing
O0R52_01450	COG2186	Transcriptional regulator
O0R52_01455	COG2721	sulfolactate sulfo-lyase activity
O0R52_01460	COG3173	Aminoglycoside phosphotransferase
O0R52_01470	COG0697	spore germination
O0R52_01475	COG0745	RESPONSE REGULATOR receiver
O0R52_01480	COG2205	protein histidine kinase activity
O0R52_01485	COG1131	(ABC) transporter
O0R52_01510	COG3773	Cell wall hydrolase
O0R52_01515	COG2304	oxidoreductase activity
O0R52_01525	COG3540	Alkaline phosphatase
O0R52_01530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O0R52_01535	COG0805	protein transport
O0R52_01540	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
O0R52_01545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O0R52_01550	COG0477	Major facilitator Superfamily
O0R52_01555	COG1309	transcriptional regulator
O0R52_01560	COG0252	asparaginase activity
O0R52_01565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
O0R52_01570	COG1714	RDD family
O0R52_01575	COG1405	negative regulation of cell septum assembly
O0R52_01575	COG3012	SEC-C Motif Domain Protein
O0R52_01580	COG3290	protein histidine kinase activity
O0R52_01585	COG3279	Response regulator of the LytR AlgR family
O0R52_01590	COG4555	ABC transporter
O0R52_01595	COG1668	transmembrane transport
O0R52_01600	COG0667	Aldo Keto reductase
O0R52_01615	COG1595	DNA-templated transcription, initiation
O0R52_01620	COG1595	DNA-templated transcription, initiation
O0R52_01625	COG1876	peptidase activity
O0R52_01630	COG0457	Tetratricopeptide repeat
O0R52_01635	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_01640	COG0366	Alpha amylase catalytic
O0R52_01645	COG0803	Belongs to the bacterial solute-binding protein 9 family
O0R52_01650	COG1121	(ABC) transporter
O0R52_01655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O0R52_01660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R52_01665	COG2310	stress, protein
O0R52_01670	COG2310	stress, protein
O0R52_01675	COG2310	stress, protein
O0R52_01680	COG0861	Integral membrane protein TerC family
O0R52_01695	COG1358	cellular component organization or biogenesis
O0R52_01710	COG3853	Toxic anion resistance protein (TelA)
O0R52_01715	COG0477	Major facilitator Superfamily
O0R52_01720	COG2814	Major facilitator Superfamily
O0R52_01725	COG0640	Transcriptional regulator
O0R52_01730	COG0517	IMP dehydrogenase activity
O0R52_01730	COG4175	Glycine betaine
O0R52_01735	COG4176	ABC-type proline glycine betaine transport system permease component
O0R52_01740	COG2113	Glycine betaine
O0R52_01745	COG1473	amidohydrolase
O0R52_01750	COG1288	antiporter activity
O0R52_01760	COG0366	Alpha amylase catalytic
O0R52_01765	COG0039	L-malate dehydrogenase activity
O0R52_01770	COG1620	l-lactate permease
O0R52_01775	COG2814	Major facilitator Superfamily
O0R52_01780	COG1846	Transcriptional regulator
O0R52_01785	COG1280	lysine exporter protein (LysE YggA)
O0R52_01790	COG3403	YqcI/YcgG family
O0R52_01795	COG1113	amino acid transport
O0R52_01800	COG3665	Urea carboxylase-associated protein
O0R52_01805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O0R52_01810	COG1660	Displays ATPase and GTPase activities
O0R52_01820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O0R52_01830	COG3458	cephalosporin-C deacetylase activity
O0R52_01835	COG3541	Predicted nucleotidyltransferase
O0R52_01840	COG0506	proline dehydrogenase activity
O0R52_01845	COG1012	belongs to the aldehyde dehydrogenase family
O0R52_01850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O0R52_01855	COG2508	Transcriptional regulator
O0R52_01860	COG3689	TIGRFAM TIGR03943 family protein
O0R52_01865	COG0701	Predicted permease
O0R52_01870	COG0492	ferredoxin-NADP+ reductase activity
O0R52_01875	COG1587	Uroporphyrinogen-III synthase
O0R52_01875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O0R52_01880	COG2146	nitrite reductase [NAD(P)H] activity
O0R52_01885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O0R52_01890	COG0243	molybdopterin cofactor binding
O0R52_01895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O0R52_01900	COG2223	nitrite transmembrane transporter activity
O0R52_01905	COG1469	GTP cyclohydrolase I activity
O0R52_01925	COG0523	cobalamin synthesis protein
O0R52_01930	COG0765	amino acid transport
O0R52_01935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R52_01940	COG1063	alcohol dehydrogenase
O0R52_01945	COG1714	RDD family
O0R52_01955	COG3842	ATPase activity
O0R52_01960	COG2723	6-phospho-beta-galactosidase activity
O0R52_01970	COG3209	COG3209 Rhs family protein
O0R52_01975	COG0840	transmembrane signaling receptor activity
O0R52_01975	COG3290	protein histidine kinase activity
O0R52_01980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O0R52_01985	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
O0R52_01990	COG1733	regulation of RNA biosynthetic process
O0R52_01995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_02025	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
O0R52_02030	COG2814	Major facilitator Superfamily
O0R52_02040	COG0697	spore germination
O0R52_02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0R52_02055	COG2364	Membrane
O0R52_02060	COG1126	abc transporter atp-binding protein
O0R52_02065	COG0765	amino acid transport
O0R52_02070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R52_02075	COG0583	DNA-binding transcription factor activity
O0R52_02085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
O0R52_02100	COG0596	Alpha beta hydrolase
O0R52_02105	COG3104	oligopeptide transport
O0R52_02110	COG5434	Belongs to the glycosyl hydrolase 28 family
O0R52_02120	COG0697	spore germination
O0R52_02130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O0R52_02135	COG1136	(ABC) transporter
O0R52_02140	COG0577	efflux transmembrane transporter activity
O0R52_02145	COG0745	RESPONSE REGULATOR receiver
O0R52_02150	COG5002	protein histidine kinase activity
O0R52_02150	COG3850	Histidine kinase
O0R52_02155	COG0457	Tetratricopeptide repeat
O0R52_02175	COG0527	aspartate kinase activity
O0R52_02180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R52_02185	COG4605	iron ion homeostasis
O0R52_02190	COG4604	ABC transporter, ATP-binding protein
O0R52_02195	COG4607	ABC-type enterochelin transport system periplasmic component
O0R52_02200	COG2814	Major facilitator Superfamily
O0R52_02205	COG1309	transcriptional regulator
O0R52_02210	COG0778	Nitroreductase
O0R52_02215	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
O0R52_02220	COG0640	Transcriptional regulator
O0R52_02225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0R52_02230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O0R52_02235	COG1012	belongs to the aldehyde dehydrogenase family
O0R52_02240	COG4975	Glucose uptake
O0R52_02245	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_02250	COG4549	nuclear export factor GLE1
O0R52_02255	COG2372	response to copper ion
O0R52_02255	COG1276	copper resistance
O0R52_02260	COG1349	DNA-binding transcription factor activity
O0R52_02270	COG2213	PTS system mannitol-specific
O0R52_02275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R52_02280	COG0246	Mannitol dehydrogenase
O0R52_02285	COG0473	3-isopropylmalate dehydrogenase activity
O0R52_02290	COG0412	Dienelactone hydrolase
O0R52_02295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O0R52_02305	COG0561	phosphatase activity
O0R52_02310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O0R52_02315	COG1914	H( )-stimulated, divalent metal cation uptake system
O0R52_02320	COG4336	lyase activity
O0R52_02325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
O0R52_02330	COG1984	allophanate hydrolase subunit 2
O0R52_02335	COG1414	Transcriptional regulator
O0R52_02340	COG2755	lipolytic protein G-D-S-L family
O0R52_02350	COG2329	Antibiotic biosynthesis monooxygenase
O0R52_02355	COG0768	penicillin binding
O0R52_02360	COG4989	oxidoreductase activity
O0R52_02365	COG3711	transcriptional antiterminator
O0R52_02370	COG0318	PFAM AMP-dependent synthetase and ligase
O0R52_02375	COG2226	methyltransferase
O0R52_02380	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_02385	COG1917	Cupin 2, conserved barrel domain protein
O0R52_02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R52_02395	COG3871	stress protein (general stress protein 26)
O0R52_02405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O0R52_02410	COG2814	Major facilitator Superfamily
O0R52_02425	COG1522	sequence-specific DNA binding
O0R52_02430	COG0551	DNA topoisomerase type I activity
O0R52_02430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O0R52_02435	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
O0R52_02440	COG3706	GGDEF domain
O0R52_02445	COG5298	Protein conserved in bacteria
O0R52_02450	COG1215	transferase activity, transferring glycosyl groups
O0R52_02460	COG0531	amino acid
O0R52_02465	COG0494	nUDIX hydrolase
O0R52_02470	COG0028	Belongs to the TPP enzyme family
O0R52_02480	COG1914	H( )-stimulated, divalent metal cation uptake system
O0R52_02485	COG2261	transglycosylase associated protein
O0R52_02490	COG4876	unkown
O0R52_02495	COG2217	Heavy metal translocating P-type atpase
O0R52_02500	COG3729	General stress protein
O0R52_02505	COG0662	Cupin 2, conserved barrel domain protein
O0R52_02510	COG2329	Antibiotic biosynthesis monooxygenase
O0R52_02520	COG3546	catalase activity
O0R52_02525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
O0R52_02530	COG3290	protein histidine kinase activity
O0R52_02535	COG4565	transcriptional regulatory protein
O0R52_02540	COG1301	dicarboxylic acid transport
O0R52_02545	COG0628	permease
O0R52_02550	COG1301	dicarboxylic acid transport
O0R52_02555	COG1131	(ABC) transporter
O0R52_02560	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O0R52_02570	COG1960	acyl-CoA dehydrogenase activity
O0R52_02585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O0R52_02590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R52_02595	COG1181	Belongs to the D-alanine--D-alanine ligase family
O0R52_02600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O0R52_02605	COG0513	Belongs to the DEAD box helicase family
O0R52_02610	COG3402	PFAM membrane-flanked domain
O0R52_02615	COG3428	Bacterial PH domain
O0R52_02620	COG0705	Rhomboid family
O0R52_02625	COG0736	holo-[acyl-carrier-protein] synthase activity
O0R52_02630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O0R52_02635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O0R52_02640	COG0864	Transcriptional regulator
O0R52_02645	COG2337	Toxic component of a toxin-antitoxin (TA) module
O0R52_02650	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R52_02655	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R52_02660	COG2172	sigma factor antagonist activity
O0R52_02665	COG2208	phosphoserine phosphatase activity
O0R52_02670	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R52_02675	COG2172	sigma factor antagonist activity
O0R52_02680	COG1191	sigma factor activity
O0R52_02685	COG2208	phosphoserine phosphatase activity
O0R52_02690	COG2183	response to ionizing radiation
O0R52_02700	COG3091	SprT-like family
O0R52_02750	COG2072	flavoprotein involved in K transport
O0R52_02765	COG2249	NAD(P)H dehydrogenase (quinone) activity
O0R52_02780	COG1846	Transcriptional regulator
O0R52_02805	COG1476	TRANSCRIPTIONal
O0R52_02815	COG3239	Fatty acid desaturase
O0R52_02820	COG1278	Cold shock
O0R52_02825	COG1278	Cold shock
O0R52_02830	COG1329	Transcriptional regulator
O0R52_02835	COG2315	Protein conserved in bacteria
O0R52_02840	COG0346	lactoylglutathione lyase activity
O0R52_02860	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
O0R52_02870	COG2364	Membrane
O0R52_02875	COG1846	Transcriptional regulator
O0R52_02880	COG0456	acetyltransferase
O0R52_02885	COG2808	Putative FMN-binding domain
O0R52_02890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O0R52_02900	COG0693	protein deglycase activity
O0R52_02910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R52_02915	COG4257	antibiotic catabolic process
O0R52_02920	COG0456	acetyltransferase
O0R52_02930	COG2030	dehydratase
O0R52_02935	COG0697	spore germination
O0R52_02940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0R52_02945	COG0596	Alpha beta hydrolase
O0R52_02950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R52_02960	COG2323	membrane
O0R52_02965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R52_02970	COG1309	transcriptional regulator
O0R52_02980	COG0456	acetyltransferase
O0R52_02985	COG0488	(ABC) transporter
O0R52_02990	COG1113	amino acid transport
O0R52_02995	COG2318	DinB family
O0R52_03000	COG1846	Transcriptional regulator
O0R52_03005	COG2409	Drug exporters of the RND superfamily
O0R52_03005	COG1033	growth of symbiont in host cell
O0R52_03015	COG0778	Nitroreductase
O0R52_03025	COG1396	sequence-specific DNA binding
O0R52_03030	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
O0R52_03040	COG2814	Major facilitator Superfamily
O0R52_03045	COG0730	response to heat
O0R52_03050	COG1802	Transcriptional regulator
O0R52_03055	COG1388	LysM domain
O0R52_03055	COG3858	chitin binding
O0R52_03060	COG1819	glycosyl
O0R52_03070	COG1785	Belongs to the alkaline phosphatase family
O0R52_03085	COG1078	dGTPase activity
O0R52_03090	COG1388	LysM domain
O0R52_03095	COG2814	Major facilitator Superfamily
O0R52_03100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O0R52_03105	COG1447	Phosphotransferase system cellobiose-specific component IIA
O0R52_03110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O0R52_03115	COG2723	6-phospho-beta-galactosidase activity
O0R52_03120	COG2188	Transcriptional regulator
O0R52_03125	COG1940	carbohydrate kinase activity
O0R52_03130	COG1482	cell wall glycoprotein biosynthetic process
O0R52_03135	COG4124	Belongs to the glycosyl hydrolase 26 family
O0R52_03180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O0R52_03185	COG0802	atpase or kinase
O0R52_03190	COG1214	PFAM Peptidase M22, glycoprotease
O0R52_03195	COG0456	acetyltransferase
O0R52_03200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O0R52_03205	COG0488	(ABC) transporter
O0R52_03210	COG0315	cyclic pyranopterin monophosphate synthase activity
O0R52_03215	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
O0R52_03220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O0R52_03225	COG0805	protein transport
O0R52_03235	COG1266	CAAX protease self-immunity
O0R52_03250	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_03265	COG0457	Tetratricopeptide repeat
O0R52_03270	COG1063	alcohol dehydrogenase
O0R52_03275	COG2211	Major facilitator Superfamily
O0R52_03280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O0R52_03290	COG2814	Major facilitator Superfamily
O0R52_03295	COG1063	alcohol dehydrogenase
O0R52_03300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O0R52_03305	COG0823	Involved in the tonB-independent uptake of proteins
O0R52_03320	COG2267	carboxylic ester hydrolase activity
O0R52_03330	COG2132	Multicopper oxidase
O0R52_03335	COG1113	amino acid transport
O0R52_03340	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O0R52_03345	COG0714	Associated with various cellular activities
O0R52_03350	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
O0R52_03355	COG1305	Transglutaminase-like
O0R52_03360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O0R52_03360	COG0519	Catalyzes the synthesis of GMP from XMP
O0R52_03365	COG2189	Belongs to the N(4) N(6)-methyltransferase family
O0R52_03395	COG2252	PERMEase
O0R52_03400	COG3064	Membrane
O0R52_03410	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
O0R52_03420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O0R52_03425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O0R52_03430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O0R52_03435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O0R52_03440	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O0R52_03445	COG0047	phosphoribosylformylglycinamidine synthase activity
O0R52_03450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O0R52_03455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O0R52_03460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O0R52_03465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O0R52_03470	COG0138	bifunctional purine biosynthesis protein purh
O0R52_03475	COG0151	Belongs to the GarS family
O0R52_03480	COG1522	sequence-specific DNA binding
O0R52_03485	COG0531	amino acid
O0R52_03495	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O0R52_03500	COG1470	cell adhesion involved in biofilm formation
O0R52_03505	COG4496	protein, YerC YecD
O0R52_03510	COG0069	glutamate synthase activity
O0R52_03515	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
O0R52_03520	COG0210	DNA helicase
O0R52_03525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O0R52_03530	COG4851	CamS sex pheromone cAM373 precursor
O0R52_03535	COG2211	Major facilitator Superfamily
O0R52_03545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O0R52_03550	COG1285	pathogenesis
O0R52_03555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O0R52_03560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O0R52_03565	COG0154	amidase activity
O0R52_03570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O0R52_03580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O0R52_03585	COG1597	lipid kinase activity
O0R52_03590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O0R52_03595	COG0745	RESPONSE REGULATOR receiver
O0R52_03610	COG3852	Histidine kinase
O0R52_03615	COG1024	Enoyl-CoA hydratase
O0R52_03620	COG1024	Enoyl-CoA hydratase
O0R52_03625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R52_03630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O0R52_03640	COG0604	alcohol dehydrogenase
O0R52_03640	COG3321	synthase
O0R52_03645	COG1131	(ABC) transporter
O0R52_03660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_03660	COG3321	synthase
O0R52_03660	COG4221	oxidoreductase activity
O0R52_03660	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_03665	COG4221	oxidoreductase activity
O0R52_03665	COG3321	synthase
O0R52_03665	COG0300	oxidoreductase activity
O0R52_03665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R52_03670	COG3321	synthase
O0R52_03670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_03670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O0R52_03670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R52_03670	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_03675	COG4221	oxidoreductase activity
O0R52_03675	COG3321	synthase
O0R52_03675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_03675	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_03680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R52_03680	COG3321	synthase
O0R52_03680	COG4221	oxidoreductase activity
O0R52_03680	COG0300	oxidoreductase activity
O0R52_03685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O0R52_03685	COG2070	2-Nitropropane dioxygenase
O0R52_03690	COG3425	synthase
O0R52_03695	COG3586	endonuclease activity
O0R52_03700	COG3391	amine dehydrogenase activity
O0R52_03705	COG0457	Tetratricopeptide repeat
O0R52_03715	COG0217	transcriptional regulatory protein
O0R52_03725	COG1309	transcriptional regulator
O0R52_03730	COG3631	Ketosteroid isomerase-related protein
O0R52_03760	COG3546	catalase activity
O0R52_03765	COG0454	-acetyltransferase
O0R52_03775	COG5578	integral membrane protein
O0R52_03780	COG2972	Histidine kinase
O0R52_03785	COG2207	Transcriptional regulator
O0R52_03785	COG4753	response regulator
O0R52_03790	COG1653	transport
O0R52_03795	COG1175	transmembrane transport
O0R52_03800	COG0395	ABC-type sugar transport system, permease component
O0R52_03805	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
O0R52_03810	COG2207	Transcriptional regulator
O0R52_03815	COG2755	lipolytic protein G-D-S-L family
O0R52_03825	COG5578	integral membrane protein
O0R52_03830	COG3401	FG-GAP repeat protein
O0R52_03835	COG3401	FG-GAP repeat protein
O0R52_03840	COG0667	Aldo Keto reductase
O0R52_03845	COG2755	lipolytic protein G-D-S-L family
O0R52_03850	COG1874	Beta-galactosidase
O0R52_03860	COG1653	transport
O0R52_03865	COG4209	transmembrane transport
O0R52_03870	COG0395	ABC-type sugar transport system, permease component
O0R52_03875	COG1486	melibiose metabolic process
O0R52_03880	COG2323	membrane
O0R52_03885	COG2329	Antibiotic biosynthesis monooxygenase
O0R52_03890	COG0346	lactoylglutathione lyase activity
O0R52_03900	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R52_03905	COG5583	Uncharacterized small protein (DUF2292)
O0R52_03910	COG0670	Belongs to the BI1 family
O0R52_03915	COG0697	spore germination
O0R52_03920	COG1846	Transcriptional regulator
O0R52_03925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O0R52_03940	COG2124	cytochrome p450
O0R52_03940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O0R52_03945	COG1368	sulfuric ester hydrolase activity
O0R52_03950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O0R52_03955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O0R52_03960	COG1442	glycosyl transferase family 8
O0R52_03965	COG1216	Glycosyl transferase, family 2
O0R52_03970	COG1442	glycosyl transferase family 8
O0R52_03975	COG2223	nitrite transmembrane transporter activity
O0R52_03980	COG1011	Hydrolase
O0R52_03985	COG0531	amino acid
O0R52_03990	COG1012	belongs to the aldehyde dehydrogenase family
O0R52_03995	COG0840	transmembrane signaling receptor activity
O0R52_04000	COG0488	(ABC) transporter
O0R52_04010	COG0789	Transcriptional regulator
O0R52_04015	COG2814	Major facilitator Superfamily
O0R52_04025	COG0488	(ABC) transporter
O0R52_04030	COG0513	Belongs to the DEAD box helicase family
O0R52_04035	COG0456	acetyltransferase
O0R52_04040	COG2130	NADP-dependent
O0R52_04045	COG1120	ATPase activity
O0R52_04050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R52_04055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R52_04060	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
O0R52_04075	COG3866	Pectate lyase
O0R52_04080	COG0471	metal ion transport
O0R52_04090	COG4565	transcriptional regulatory protein
O0R52_04095	COG3181	Tripartite tricarboxylate transporter family receptor
O0R52_04100	COG2851	Citrate transporter
O0R52_04105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R52_04110	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
O0R52_04115	COG1254	Belongs to the acylphosphatase family
O0R52_04120	COG2258	MOSC domain
O0R52_04140	COG0024	Methionine aminopeptidase
O0R52_04145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R52_04145	COG1263	PTS System
O0R52_04150	COG1368	sulfuric ester hydrolase activity
O0R52_04160	COG1115	amino acid carrier protein
O0R52_04165	COG0531	amino acid
O0R52_04180	COG0697	spore germination
O0R52_04185	COG1263	PTS System
O0R52_04185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R52_04190	COG0366	Alpha amylase catalytic
O0R52_04195	COG2188	Transcriptional regulator
O0R52_04200	COG0778	Nitroreductase
O0R52_04205	COG0737	Belongs to the 5'-nucleotidase family
O0R52_04210	COG0693	protein deglycase activity
O0R52_04215	COG2814	Major facilitator Superfamily
O0R52_04220	COG4840	Belongs to the UPF0435 family
O0R52_04225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O0R52_04230	COG4980	gas vesicle protein
O0R52_04235	COG1295	ribonuclease BN
O0R52_04240	COG0477	Major facilitator Superfamily
O0R52_04245	COG0387	Pfam Sodium calcium exchanger
O0R52_04255	COG0668	transmembrane transport
O0R52_04260	COG0535	radical SAM domain protein
O0R52_04270	COG0726	polysaccharide deacetylase
O0R52_04275	COG2084	Dehydrogenase
O0R52_04280	COG0598	Magnesium transport protein CorA
O0R52_04285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
O0R52_04290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O0R52_04295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O0R52_04305	COG4637	Psort location Cytoplasmic, score
O0R52_04315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O0R52_04320	COG0022	dehydrogenase e1 component
O0R52_04325	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0R52_04330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O0R52_04335	COG3284	Transcriptional regulator
O0R52_04370	COG4842	Belongs to the WXG100 family
O0R52_04375	COG1486	melibiose metabolic process
O0R52_04380	COG1737	Transcriptional regulator
O0R52_04385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R52_04385	COG1263	PTS System
O0R52_04390	COG1132	(ABC) transporter
O0R52_04395	COG1132	(ABC) transporter
O0R52_04400	COG2259	Doxx family
O0R52_04405	COG2514	catechol 2,3-dioxygenase activity
O0R52_04410	COG4585	Histidine kinase
O0R52_04415	COG2197	response regulator
O0R52_04420	COG1131	(ABC) transporter
O0R52_04425	COG0842	Transport permease protein
O0R52_04425	COG1511	domain protein
O0R52_04430	COG0842	Transport permease protein
O0R52_04440	COG1695	Transcriptional regulator
O0R52_04445	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
O0R52_04450	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
O0R52_04455	COG2318	DinB family
O0R52_04460	COG2814	Major facilitator Superfamily
O0R52_04465	COG1846	Transcriptional regulator
O0R52_04470	COG0392	lysyltransferase activity
O0R52_04470	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O0R52_04475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R52_04480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R52_04485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R52_04490	COG0384	phenazine biosynthesis protein PhzF
O0R52_04495	COG0778	Nitroreductase
O0R52_04510	COG1090	epimerase
O0R52_04515	COG2137	regulation of response to DNA damage stimulus
O0R52_04525	COG2814	Major facilitator Superfamily
O0R52_04545	COG1476	TRANSCRIPTIONal
O0R52_04550	COG3103	Sh3 type 3 domain protein
O0R52_04555	COG5658	integral membrane protein
O0R52_04560	COG0596	Alpha beta hydrolase
O0R52_04565	COG0463	Glycosyl transferase, family 2
O0R52_04570	COG4485	Bacterial membrane protein, YfhO
O0R52_04575	COG1988	membrane-bound metal-dependent
O0R52_04580	COG1194	a g-specific adenine glycosylase
O0R52_04590	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_04605	COG3557	Belongs to the UPF0374 family
O0R52_04610	COG1132	(ABC) transporter
O0R52_04615	COG4129	membrane
O0R52_04620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O0R52_04625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O0R52_04630	COG0735	belongs to the Fur family
O0R52_04740	COG4326	sporulation control protein
O0R52_04750	COG1063	alcohol dehydrogenase
O0R52_04755	COG5577	PFAM Coat F domain
O0R52_04770	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O0R52_04780	COG0753	catalase activity
O0R52_04785	COG1116	anion transmembrane transporter activity
O0R52_04790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O0R52_04795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O0R52_04800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R52_04810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O0R52_04820	COG1476	TRANSCRIPTIONal
O0R52_04830	COG3382	B3 4 domain protein
O0R52_04835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O0R52_04845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O0R52_04850	COG0789	Transcriptional regulator
O0R52_04855	COG1664	Polymer-forming cytoskeletal
O0R52_04860	COG1664	Polymer-forming cytoskeletal
O0R52_04865	COG2766	serine protein kinase
O0R52_04870	COG2718	Belongs to the UPF0229 family
O0R52_04875	COG1846	Transcriptional regulator
O0R52_04885	COG2814	Major facilitator Superfamily
O0R52_04890	COG0655	NAD(P)H dehydrogenase (quinone) activity
O0R52_04905	COG1725	Transcriptional regulator
O0R52_04910	COG1131	(ABC) transporter
O0R52_04915	COG1131	(ABC) transporter
O0R52_04920	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O0R52_04925	COG1278	Cold shock
O0R52_04930	COG1464	Belongs to the NlpA lipoprotein family
O0R52_04935	COG3706	GGDEF domain
O0R52_04940	COG1823	symporter activity
O0R52_04945	COG5444	nuclease activity
O0R52_04985	COG5577	PFAM Coat F domain
O0R52_04990	COG4085	toxin activity
O0R52_04990	COG0737	Belongs to the 5'-nucleotidase family
O0R52_04990	COG1525	nuclease
O0R52_04995	COG3764	Sortase (surface protein transpeptidase)
O0R52_05000	COG0564	pseudouridine synthase activity
O0R52_05010	COG0517	IMP dehydrogenase activity
O0R52_05015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O0R52_05020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O0R52_05020	COG3153	acetyltransferase
O0R52_05030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O0R52_05035	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
O0R52_05040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O0R52_05045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O0R52_05050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O0R52_05055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O0R52_05060	COG2203	Gaf domain
O0R52_05060	COG4585	Histidine kinase
O0R52_05065	COG2197	response regulator
O0R52_05070	COG0431	NADPH-dependent FMN reductase
O0R52_05085	COG0791	NLP P60 protein
O0R52_05085	COG1388	LysM domain
O0R52_05090	COG1959	2 iron, 2 sulfur cluster binding
O0R52_05100	COG2719	SpoVR family
O0R52_05110	COG1785	Belongs to the alkaline phosphatase family
O0R52_05115	COG0791	NLP P60 protein
O0R52_05115	COG1388	LysM domain
O0R52_05120	COG0583	DNA-binding transcription factor activity
O0R52_05125	COG0372	Belongs to the citrate synthase family
O0R52_05130	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_05135	COG0531	amino acid
O0R52_05140	COG0733	neurotransmitter:sodium symporter activity
O0R52_05145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0R52_05150	COG0456	acetyltransferase
O0R52_05165	COG1595	DNA-templated transcription, initiation
O0R52_05170	COG0667	Aldo Keto reductase
O0R52_05175	COG0204	Acyl-transferase
O0R52_05180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O0R52_05185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O0R52_05190	COG1253	flavin adenine dinucleotide binding
O0R52_05195	COG0789	Transcriptional regulator
O0R52_05200	COG0436	Aminotransferase
O0R52_05205	COG1253	flavin adenine dinucleotide binding
O0R52_05210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O0R52_05215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O0R52_05220	COG0584	glycerophosphoryl diester phosphodiesterase
O0R52_05230	COG0668	transmembrane transport
O0R52_05235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O0R52_05240	COG0726	polysaccharide deacetylase
O0R52_05245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O0R52_05250	COG1757	Na H antiporter
O0R52_05255	COG0589	response to stress
O0R52_05260	COG1132	(ABC) transporter
O0R52_05265	COG1132	(ABC) transporter
O0R52_05270	COG0702	epimerase
O0R52_05290	COG0189	ligase activity
O0R52_05295	COG0189	ligase activity
O0R52_05300	COG4399	Belongs to the UPF0754 family
O0R52_05305	COG3679	Belongs to the UPF0342 family
O0R52_05310	COG4335	DNA alkylation repair
O0R52_05315	COG0561	phosphatase activity
O0R52_05320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O0R52_05325	COG0475	glutathione-regulated potassium exporter activity
O0R52_05330	COG0490	domain, Protein
O0R52_05340	COG1024	Enoyl-CoA hydratase
O0R52_05350	COG4152	abc transporter atp-binding protein
O0R52_05355	COG1668	transmembrane transport
O0R52_05360	COG0420	3'-5' exonuclease activity
O0R52_05365	COG4717	serine-type aminopeptidase activity
O0R52_05370	COG3481	metal-dependent phosphohydrolase, HD sub domain
O0R52_05380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O0R52_05410	COG1846	Transcriptional regulator
O0R52_05415	COG4980	gas vesicle protein
O0R52_05430	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O0R52_05435	COG0537	adenosine 5'-monophosphoramidase activity
O0R52_05440	COG1131	(ABC) transporter
O0R52_05445	COG4473	ABC transporter
O0R52_05455	COG1473	amidohydrolase
O0R52_05460	COG3069	C4-dicarboxylate transmembrane transporter activity
O0R52_05465	COG2329	Antibiotic biosynthesis monooxygenase
O0R52_05470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O0R52_05475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O0R52_05480	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O0R52_05485	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
O0R52_05490	COG1309	transcriptional regulator
O0R52_05495	COG1511	domain protein
O0R52_05500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O0R52_05505	COG4377	Putative membrane peptidase family (DUF2324)
O0R52_05515	COG1363	Peptidase, m42
O0R52_05520	COG4405	Protein conserved in bacteria
O0R52_05525	COG1301	dicarboxylic acid transport
O0R52_05535	COG1234	tRNA 3'-trailer cleavage
O0R52_05540	COG0095	Lipoate-protein ligase
O0R52_05545	COG0702	epimerase
O0R52_05550	COG0318	PFAM AMP-dependent synthetase and ligase
O0R52_05560	COG0501	Belongs to the peptidase M48B family
O0R52_05565	COG1404	Belongs to the peptidase S8 family
O0R52_05570	COG0456	acetyltransferase
O0R52_05575	COG0604	alcohol dehydrogenase
O0R52_05580	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
O0R52_05585	COG0406	alpha-ribazole phosphatase activity
O0R52_05590	COG0183	Belongs to the thiolase family
O0R52_05595	COG0318	PFAM AMP-dependent synthetase and ligase
O0R52_05600	COG1268	BioY protein
O0R52_05605	COG0840	transmembrane signaling receptor activity
O0R52_05610	COG0723	plastoquinol--plastocyanin reductase activity
O0R52_05610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O0R52_05615	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_05625	COG4903	ComK protein
O0R52_05630	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_05640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O0R52_05655	COG0398	Pfam SNARE associated Golgi protein
O0R52_05660	COG0681	Belongs to the peptidase S26 family
O0R52_05665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O0R52_05670	COG1846	Transcriptional regulator
O0R52_05680	COG0738	Major facilitator superfamily
O0R52_05685	COG0673	inositol 2-dehydrogenase activity
O0R52_05690	COG0561	phosphatase activity
O0R52_05695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O0R52_05700	COG1609	Transcriptional regulator
O0R52_05705	COG3180	Ammonia monooxygenase
O0R52_05715	COG4533	DNA binding
O0R52_05725	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
O0R52_05730	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
O0R52_05735	COG1074	ATP-dependent DNA helicase activity
O0R52_05740	COG0420	3'-5' exonuclease activity
O0R52_05745	COG0419	ATPase involved in DNA repair
O0R52_05750	COG1403	HNH endonuclease
O0R52_05790	COG5337	Spore coat protein CotH
O0R52_05795	COG0179	Fumarylacetoacetate (FAA) hydrolase
O0R52_05805	COG1404	Belongs to the peptidase S8 family
O0R52_05815	COG0367	asparagine synthase
O0R52_05820	COG2318	DinB family
O0R52_05830	COG0534	Mate efflux family protein
O0R52_05835	COG2207	Transcriptional regulator
O0R52_05835	COG1917	Cupin 2, conserved barrel domain protein
O0R52_05840	COG1609	Transcriptional regulator
O0R52_05845	COG0673	inositol 2-dehydrogenase activity
O0R52_05850	COG2318	DinB family
O0R52_05855	COG1279	arginine transmembrane transporter activity
O0R52_05860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0R52_05865	COG1357	PFAM Pentapeptide repeats (8 copies)
O0R52_05870	COG2267	carboxylic ester hydrolase activity
O0R52_05875	COG0529	Catalyzes the synthesis of activated sulfate
O0R52_05880	COG2046	Belongs to the sulfate adenylyltransferase family
O0R52_05885	COG0175	sulfate reduction
O0R52_05890	COG2045	Belongs to the ComB family
O0R52_05895	COG1809	phosphosulfolactate synthase activity
O0R52_05900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R52_05905	COG4948	Mandelate Racemase Muconate Lactonizing
O0R52_05910	COG2814	Major facilitator Superfamily
O0R52_05920	COG2153	protein acetylation
O0R52_05925	COG0646	methionine synthase
O0R52_05925	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
O0R52_05930	COG1666	GTP binding
O0R52_05935	COG2996	Protein conserved in bacteria
O0R52_05955	COG1695	Transcriptional regulator
O0R52_05970	COG3227	Zinc metalloprotease (Elastase)
O0R52_05975	COG1307	EDD domain protein, DegV family
O0R52_05980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R52_06000	COG0561	phosphatase activity
O0R52_06005	COG1073	alpha beta
O0R52_06010	COG2151	metal-sulfur cluster biosynthetic enzyme
O0R52_06020	COG0277	FAD linked oxidase domain protein
O0R52_06025	COG2271	Major facilitator Superfamily
O0R52_06030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O0R52_06035	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O0R52_06045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O0R52_06050	COG0505	Belongs to the CarA family
O0R52_06055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O0R52_06060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O0R52_06075	COG2267	carboxylic ester hydrolase activity
O0R52_06085	COG1744	ABC transporter substrate-binding protein PnrA-like
O0R52_06100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O0R52_06105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O0R52_06110	COG5504	Zn-dependent protease
O0R52_06115	COG0444	Belongs to the ABC transporter superfamily
O0R52_06120	COG4608	Belongs to the ABC transporter superfamily
O0R52_06130	COG0601	transmembrane transport
O0R52_06135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0R52_06145	COG0180	Tryptophanyl-tRNA synthetase
O0R52_06150	COG4166	transmembrane transport
O0R52_06155	COG0601	transmembrane transport
O0R52_06160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0R52_06165	COG0444	Belongs to the ABC transporter superfamily
O0R52_06170	COG4608	Belongs to the ABC transporter superfamily
O0R52_06175	COG2814	Major facilitator Superfamily
O0R52_06180	COG0456	acetyltransferase
O0R52_06185	COG1393	Belongs to the ArsC family
O0R52_06190	COG0861	Integral membrane protein TerC family
O0R52_06200	COG4862	establishment of competence for transformation
O0R52_06205	COG4469	Competence protein
O0R52_06210	COG1164	Oligoendopeptidase f
O0R52_06220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O0R52_06225	COG2346	COG2346, Truncated hemoglobins
O0R52_06230	COG0741	lytic transglycosylase activity
O0R52_06235	COG4116	CYTH
O0R52_06245	COG2357	RelA SpoT domain protein
O0R52_06250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O0R52_06255	COG0564	pseudouridine synthase activity
O0R52_06260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O0R52_06265	COG0569	domain protein
O0R52_06265	COG0475	glutathione-regulated potassium exporter activity
O0R52_06270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O0R52_06275	COG0352	thiamine-phosphate diphosphorylase activity
O0R52_06280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O0R52_06285	COG2104	thiamine diphosphate biosynthetic process
O0R52_06290	COG2022	thiamine diphosphate biosynthetic process
O0R52_06295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O0R52_06300	COG0351	phosphomethylpyrimidine kinase
O0R52_06305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O0R52_06360	COG0210	DNA helicase
O0R52_06370	COG2153	protein acetylation
O0R52_06375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
O0R52_06380	COG2382	esterase
O0R52_06385	COG0626	cystathionine gamma-synthase activity
O0R52_06390	COG0626	cystathionine gamma-synthase activity
O0R52_06395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R52_06400	COG5505	Protein of unknown function (DUF819)
O0R52_06410	COG0457	Tetratricopeptide repeat
O0R52_06445	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_06465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R52_06475	COG0789	Transcriptional regulator
O0R52_06490	COG0109	protoheme IX farnesyltransferase activity
O0R52_06500	COG0726	polysaccharide deacetylase
O0R52_06515	COG5504	Zn-dependent protease
O0R52_06520	COG2205	protein histidine kinase activity
O0R52_06530	COG3383	formate dehydrogenase (NAD+) activity
O0R52_06535	COG2427	Protein of unknown function (DUF1641)
O0R52_06545	COG1051	belongs to the nudix hydrolase family
O0R52_06555	COG2124	cytochrome p450
O0R52_06560	COG1819	glycosyl
O0R52_06575	COG1587	Uroporphyrinogen-III synthase
O0R52_06580	COG0390	transport system, permease component
O0R52_06585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O0R52_06590	COG0697	spore germination
O0R52_06595	COG4297	protein containing double-stranded beta helix domain
O0R52_06605	COG1252	NADH dehydrogenase
O0R52_06610	COG1904	glucuronate isomerase
O0R52_06615	COG2211	Major facilitator Superfamily
O0R52_06620	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
O0R52_06625	COG1063	alcohol dehydrogenase
O0R52_06630	COG1312	Catalyzes the dehydration of D-mannonate
O0R52_06635	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_06640	COG2271	Major facilitator Superfamily
O0R52_06645	COG1609	Transcriptional regulator
O0R52_06650	COG0246	Mannitol dehydrogenase
O0R52_06655	COG2721	sulfolactate sulfo-lyase activity
O0R52_06660	COG0730	response to heat
O0R52_06665	COG2318	DinB family
O0R52_06670	COG0457	Tetratricopeptide repeat
O0R52_06680	COG2350	Protein conserved in bacteria
O0R52_06685	COG5632	N-Acetylmuramoyl-L-alanine amidase
O0R52_06685	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_06685	COG1388	LysM domain
O0R52_06695	COG4195	phage-related replication protein
O0R52_06700	COG3546	catalase activity
O0R52_06705	COG2856	Zn peptidase
O0R52_06710	COG1396	sequence-specific DNA binding
O0R52_06720	COG1522	sequence-specific DNA binding
O0R52_06725	COG1484	DNA-dependent DNA replication
O0R52_06745	COG1595	DNA-templated transcription, initiation
O0R52_06750	COG5484	DNA packaging
O0R52_06750	COG3728	DNA packaging
O0R52_06755	COG1783	phage Terminase large subunit
O0R52_06760	COG5518	Phage portal protein
O0R52_06765	COG0338	D12 class N6 adenine-specific DNA methyltransferase
O0R52_06820	COG3953	SLT domain
O0R52_06820	COG5412	phage tail tape measure protein
O0R52_06825	COG1652	LysM domain
O0R52_06830	COG4193	domain, Protein
O0R52_06840	COG3628	GPW Gp25 family protein
O0R52_06845	COG3299	homolog of phage Mu protein gp47
O0R52_06850	COG3778	Protein conserved in bacteria
O0R52_06895	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_06895	COG5632	N-Acetylmuramoyl-L-alanine amidase
O0R52_06915	COG0306	phosphate transporter
O0R52_06920	COG1392	Phosphate transport regulator
O0R52_06925	COG0531	amino acid
O0R52_06930	COG0346	lactoylglutathione lyase activity
O0R52_06940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O0R52_06945	COG0463	Glycosyl transferase, family 2
O0R52_06955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0R52_06960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O0R52_06965	COG2362	D-Aminopeptidase
O0R52_06970	COG0601	transmembrane transport
O0R52_06975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0R52_06980	COG0444	Belongs to the ABC transporter superfamily
O0R52_06985	COG4166	transmembrane transport
O0R52_06990	COG1619	proteins homologs of microcin C7 resistance protein MccF
O0R52_06995	COG4948	Mandelate Racemase Muconate Lactonizing
O0R52_07000	COG0791	NLP P60 protein
O0R52_07005	COG4608	Belongs to the ABC transporter superfamily
O0R52_07010	COG2706	6-phosphogluconolactonase activity
O0R52_07015	COG1834	amidinotransferase
O0R52_07020	COG1607	acyl-coa hydrolase
O0R52_07025	COG1017	nitric oxide dioxygenase activity
O0R52_07025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O0R52_07035	COG2323	membrane
O0R52_07040	COG2318	DinB family
O0R52_07045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R52_07050	COG2076	Multidrug Resistance protein
O0R52_07055	COG2076	Multidrug Resistance protein
O0R52_07060	COG0788	formyltetrahydrofolate deformylase activity
O0R52_07065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O0R52_07070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O0R52_07075	COG1764	response to oxidative stress
O0R52_07080	COG1846	Transcriptional regulator
O0R52_07085	COG1764	response to oxidative stress
O0R52_07090	COG0457	Tetratricopeptide repeat
O0R52_07090	COG0463	Glycosyl transferase, family 2
O0R52_07100	COG0590	tRNA wobble adenosine to inosine editing
O0R52_07105	COG0406	alpha-ribazole phosphatase activity
O0R52_07110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O0R52_07115	COG1404	Belongs to the peptidase S8 family
O0R52_07120	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R52_07125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O0R52_07130	COG1122	ATPase activity
O0R52_07135	COG4721	ABC-type cobalt transport system, permease component
O0R52_07145	COG0745	RESPONSE REGULATOR receiver
O0R52_07150	COG3850	Histidine kinase
O0R52_07150	COG5002	protein histidine kinase activity
O0R52_07155	COG3212	peptidase
O0R52_07160	COG3212	peptidase
O0R52_07175	COG2239	Acts as a magnesium transporter
O0R52_07180	COG0789	Transcriptional regulator
O0R52_07195	COG1846	Transcriptional regulator
O0R52_07200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O0R52_07205	COG0726	polysaccharide deacetylase
O0R52_07210	COG1408	metallophosphoesterase
O0R52_07220	COG0463	Glycosyl transferase, family 2
O0R52_07225	COG1793	dna ligase
O0R52_07225	COG3285	dna ligase
O0R52_07230	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O0R52_07235	COG3300	MHYT domain
O0R52_07235	COG5001	Diguanylate cyclase
O0R52_07240	COG0586	Pfam SNARE associated Golgi protein
O0R52_07250	COG1191	sigma factor activity
O0R52_07270	COG0501	Belongs to the peptidase M48B family
O0R52_07275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O0R52_07290	COG3594	Acyltransferase
O0R52_07295	COG5002	protein histidine kinase activity
O0R52_07300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O0R52_07310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
O0R52_07315	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
O0R52_07320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O0R52_07325	COG0436	Aminotransferase
O0R52_07330	COG1850	ribulose-bisphosphate carboxylase activity
O0R52_07335	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
O0R52_07340	COG0235	Class ii aldolase
O0R52_07345	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
O0R52_07350	COG3339	Conserved Protein
O0R52_07365	COG3852	Histidine kinase
O0R52_07370	COG1846	Transcriptional regulator
O0R52_07375	COG1360	Flagellar Motor Protein
O0R52_07380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O0R52_07385	COG0542	response to heat
O0R52_07390	COG3949	Membrane
O0R52_07395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O0R52_07400	COG0720	synthase
O0R52_07405	COG0602	queuosine metabolic process
O0R52_07410	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O0R52_07415	COG1388	LysM domain
O0R52_07415	COG4641	Protein conserved in bacteria
O0R52_07420	COG1388	LysM domain
O0R52_07425	COG3858	chitin binding
O0R52_07435	COG4873	Protein conserved in bacteria
O0R52_07445	COG3773	Cell wall hydrolase
O0R52_07450	COG2244	polysaccharide biosynthetic process
O0R52_07455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R52_07460	COG2217	Heavy metal translocating P-type atpase
O0R52_07470	COG0006	proline dipeptidase activity
O0R52_07480	COG1609	Transcriptional regulator
O0R52_07485	COG3711	transcriptional antiterminator
O0R52_07490	COG1263	PTS System
O0R52_07490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R52_07490	COG2190	(PTS) system
O0R52_07495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R52_07500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O0R52_07510	COG1533	DNA photolyase activity
O0R52_07515	COG0456	acetyltransferase
O0R52_07520	COG0840	transmembrane signaling receptor activity
O0R52_07525	COG2084	Dehydrogenase
O0R52_07530	COG2340	Cysteine-rich secretory protein family
O0R52_07535	COG0768	penicillin binding
O0R52_07540	COG4191	Histidine kinase
O0R52_07545	COG0436	Aminotransferase
O0R52_07555	COG0784	Response regulator, receiver
O0R52_07555	COG0835	chemotaxis
O0R52_07565	COG2814	Major facilitator Superfamily
O0R52_07570	COG1376	ErfK ybiS ycfS ynhG family protein
O0R52_07575	COG1408	metallophosphoesterase
O0R52_07580	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_07585	COG2200	EAL domain
O0R52_07590	COG3546	catalase activity
O0R52_07595	COG4703	Protein of unknown function (DUF1797)
O0R52_07600	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
O0R52_07610	COG0517	IMP dehydrogenase activity
O0R52_07615	COG0583	DNA-binding transcription factor activity
O0R52_07620	COG0716	FMN binding
O0R52_07630	COG0716	FMN binding
O0R52_07635	COG2171	N-acyltransferase activity
O0R52_07640	COG1473	amidohydrolase
O0R52_07650	COG0668	transmembrane transport
O0R52_07655	COG0450	alkyl hydroperoxide reductase
O0R52_07660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R52_07675	COG0746	molybdenum cofactor guanylyltransferase activity
O0R52_07680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O0R52_07685	COG0303	'Molybdopterin
O0R52_07690	COG1763	Mo-molybdopterin cofactor biosynthetic process
O0R52_07695	COG0314	molybdopterin synthase activity
O0R52_07700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O0R52_07705	COG1132	(ABC) transporter
O0R52_07710	COG1132	(ABC) transporter
O0R52_07720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O0R52_07725	COG1136	(ABC) transporter
O0R52_07730	COG0577	efflux transmembrane transporter activity
O0R52_07735	COG1349	DNA-binding transcription factor activity
O0R52_07740	COG1105	Belongs to the carbohydrate kinase PfkB family
O0R52_07745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O0R52_07745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O0R52_07745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R52_07750	COG0681	Belongs to the peptidase S26 family
O0R52_07765	COG0488	(ABC) transporter
O0R52_07770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O0R52_07775	COG2309	aminopeptidase activity
O0R52_07785	COG1077	Cell shape determining protein MreB Mrl
O0R52_07790	COG2002	toxin-antitoxin pair type II binding
O0R52_07795	COG3852	Histidine kinase
O0R52_07800	COG2105	PFAM AIG2 family protein
O0R52_07800	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
O0R52_07805	COG0569	domain protein
O0R52_07810	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O0R52_07815	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O0R52_07820	COG5503	Protein of unknown function (DUF1447)
O0R52_07825	COG0561	phosphatase activity
O0R52_07830	COG0242	peptide deformylase activity
O0R52_07840	COG0497	DNA recombination
O0R52_07845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O0R52_07850	COG0022	dehydrogenase e1 component
O0R52_07855	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0R52_07860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O0R52_07865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R52_07875	COG1982	Orn Lys Arg decarboxylase major
O0R52_07880	COG4476	Belongs to the UPF0223 family
O0R52_07885	COG4493	Belongs to the UPF0637 family
O0R52_07895	COG0483	inositol monophosphate 1-phosphatase activity
O0R52_07905	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
O0R52_07935	COG1217	gtp-binding protein TYPA
O0R52_07945	COG4896	Protein conserved in bacteria
O0R52_07955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O0R52_07960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O0R52_07965	COG2066	Belongs to the glutaminase family
O0R52_07970	COG4838	Belongs to the UPF0358 family
O0R52_07975	COG0772	Belongs to the SEDS family
O0R52_07980	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
O0R52_07985	COG1612	heme a metabolic process
O0R52_07990	COG0109	protoheme IX farnesyltransferase activity
O0R52_07995	COG2010	Cytochrome c
O0R52_07995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O0R52_08000	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O0R52_08005	COG1845	cytochrome c oxidase, subunit III
O0R52_08010	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O0R52_08015	COG3336	cytochrome c oxidase
O0R52_08025	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
O0R52_08030	COG2340	Cysteine-rich secretory protein family
O0R52_08045	COG3679	Belongs to the UPF0342 family
O0R52_08050	COG4471	UPF0298 protein
O0R52_08055	COG0742	ribosomal rna small subunit methyltransferase
O0R52_08060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O0R52_08065	COG3314	Sporulation integral membrane protein YlbJ
O0R52_08070	COG1752	Esterase of the alpha-beta hydrolase superfamily
O0R52_08075	COG3480	Lon protease (S16) C-terminal proteolytic domain
O0R52_08080	COG1323	Belongs to the UPF0348 family
O0R52_08090	COG1399	metal-binding, possibly nucleic acid-binding protein
O0R52_08105	COG0454	-acetyltransferase
O0R52_08110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O0R52_08115	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
O0R52_08120	COG2001	Belongs to the MraZ family
O0R52_08125	COG0275	rRNA processing
O0R52_08130	COG4839	cell division protein FtsL
O0R52_08135	COG0768	penicillin binding
O0R52_08140	COG0768	penicillin binding
O0R52_08145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O0R52_08150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O0R52_08155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O0R52_08160	COG0772	Belongs to the SEDS family
O0R52_08165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O0R52_08170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O0R52_08175	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O0R52_08180	COG3879	Bacterial protein of unknown function (DUF881)
O0R52_08185	COG3879	Bacterial protein of unknown function (DUF881)
O0R52_08190	COG3856	small basic protein
O0R52_08195	COG0849	cell division
O0R52_08200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O0R52_08205	COG1404	Belongs to the peptidase S8 family
O0R52_08205	COG4412	M6 family metalloprotease domain protein
O0R52_08215	COG1191	sigma factor activity
O0R52_08220	COG1191	sigma factor activity
O0R52_08225	COG1119	ATPase activity
O0R52_08230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O0R52_08235	COG1873	PFAM PRC-barrel domain
O0R52_08240	COG1496	oxidoreductase activity
O0R52_08245	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O0R52_08250	COG1799	cell septum assembly
O0R52_08255	COG0762	integral membrane protein
O0R52_08260	COG2302	S4 RNA-binding domain
O0R52_08265	COG3599	regulation of cell shape
O0R52_08270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O0R52_08275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O0R52_08280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O0R52_08285	COG0564	pseudouridine synthase activity
O0R52_08290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
O0R52_08295	COG2233	PERMEase
O0R52_08300	COG0540	Belongs to the ATCase OTCase family
O0R52_08305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O0R52_08310	COG0505	Belongs to the CarA family
O0R52_08315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O0R52_08320	COG0543	2 iron, 2 sulfur cluster binding
O0R52_08325	COG0167	dihydroorotate dehydrogenase activity
O0R52_08330	COG0284	orotidine-5'-phosphate decarboxylase activity
O0R52_08335	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O0R52_08340	COG0175	sulfate reduction
O0R52_08345	COG0306	phosphate transporter
O0R52_08350	COG2046	Belongs to the sulfate adenylyltransferase family
O0R52_08355	COG0529	Catalyzes the synthesis of activated sulfate
O0R52_08360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O0R52_08365	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
O0R52_08370	COG1648	precorrin-2 dehydrogenase activity
O0R52_08375	COG1293	RNA-binding protein homologous to eukaryotic snRNP
O0R52_08380	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O0R52_08385	COG1561	YicC-like family, N-terminal region
O0R52_08395	COG0194	GDP metabolic process
O0R52_08400	COG1758	RNA polymerase activity
O0R52_08405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O0R52_08410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O0R52_08415	COG0242	peptide deformylase activity
O0R52_08420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O0R52_08425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O0R52_08425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O0R52_08430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O0R52_08435	COG0631	protein serine/threonine phosphatase activity
O0R52_08440	COG0515	serine threonine protein kinase
O0R52_08440	COG2815	serine threonine protein kinase
O0R52_08445	COG1162	GTPase activity
O0R52_08450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O0R52_08455	COG1564	THIamine pyrophosphokinase
O0R52_08465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O0R52_08470	COG1302	Protein conserved in bacteria
O0R52_08475	COG1461	Dihydroxyacetone kinase
O0R52_08480	COG1760	l-serine dehydratase
O0R52_08485	COG1760	l-serine dehydratase
O0R52_08490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O0R52_08495	COG1349	DNA-binding transcription factor activity
O0R52_08495	COG2050	protein possibly involved in aromatic compounds catabolism
O0R52_08500	COG0416	fatty acid biosynthetic process
O0R52_08505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O0R52_08510	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_08520	COG0571	ribonuclease III activity
O0R52_08525	COG1196	nuclear chromosome segregation
O0R52_08530	COG0552	protein localization to endoplasmic reticulum
O0R52_08540	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
O0R52_08545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O0R52_08550	COG0228	four-way junction DNA binding
O0R52_08555	COG1837	Belongs to the UPF0109 family
O0R52_08565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O0R52_08570	COG0336	Belongs to the RNA methyltransferase TrmD family
O0R52_08575	COG0335	large ribosomal subunit rRNA binding
O0R52_08580	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O0R52_08585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O0R52_08595	COG2257	FlhB HrpN YscU SpaS Family
O0R52_08600	COG0045	succinate-CoA ligase (ADP-forming) activity
O0R52_08605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
O0R52_08610	COG0758	DNA mediated transformation
O0R52_08615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O0R52_08620	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
O0R52_08625	COG4974	Belongs to the 'phage' integrase family
O0R52_08630	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O0R52_08635	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O0R52_08640	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O0R52_08645	COG1815	bacterial-type flagellum-dependent cell motility
O0R52_08650	COG1558	bacterial-type flagellum-dependent cell motility
O0R52_08655	COG1677	Flagellar hook-basal body complex protein FliE
O0R52_08660	COG1766	The M ring may be actively involved in energy transduction
O0R52_08665	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O0R52_08670	COG1317	bacterial-type flagellum organization
O0R52_08675	COG1157	protein secretion by the type III secretion system
O0R52_08680	COG2882	bacterial-type flagellum organization
O0R52_08685	COG3334	PFAM MgtE intracellular
O0R52_08690	COG3144	bacterial-type flagellum assembly
O0R52_08695	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
O0R52_08700	COG4786	Flagellar basal body rod
O0R52_08705	COG1582	Flagellar protein (FlbD)
O0R52_08710	COG1580	Controls the rotational direction of flagella during chemotaxis
O0R52_08715	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O0R52_08720	COG1776	CheC inhibitor of MCP methylation
O0R52_08720	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O0R52_08725	COG2201	protein-glutamate methylesterase activity
O0R52_08730	COG3190	flagellar
O0R52_08735	COG1338	Plays a role in the flagellum-specific transport system
O0R52_08740	COG1987	bacterial-type flagellum assembly
O0R52_08745	COG1684	flagellar biosynthetic protein fliR
O0R52_08750	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O0R52_08755	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O0R52_08760	COG1419	protein localization to endoplasmic reticulum
O0R52_08765	COG0455	bacterial-type flagellum organization
O0R52_08770	COG2201	protein-glutamate methylesterase activity
O0R52_08775	COG0643	Histidine kinase
O0R52_08775	COG2198	Histidine kinase
O0R52_08780	COG0835	chemotaxis
O0R52_08785	COG1776	CheC inhibitor of MCP methylation
O0R52_08790	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
O0R52_08795	COG1191	sigma factor activity
O0R52_08805	COG0052	Belongs to the universal ribosomal protein uS2 family
O0R52_08810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O0R52_08815	COG0528	UMP kinase activity
O0R52_08820	COG0233	cytoplasmic translational termination
O0R52_08825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O0R52_08830	COG4589	Belongs to the CDS family
O0R52_08835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O0R52_08840	COG0750	zinc metalloprotease
O0R52_08845	COG0442	prolyl-tRNA aminoacylation
O0R52_08850	COG2176	DNA-directed DNA polymerase activity
O0R52_08855	COG0779	Required for maturation of 30S ribosomal subunits
O0R52_08860	COG0195	Participates in both transcription termination and antitermination
O0R52_08865	COG2740	Nucleic-acid-binding protein implicated in transcription termination
O0R52_08870	COG1358	cellular component organization or biogenesis
O0R52_08875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O0R52_08880	COG1550	Protein conserved in bacteria
O0R52_08885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O0R52_08890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O0R52_08895	COG0196	riboflavin kinase activity
O0R52_08905	COG1185	polyribonucleotide nucleotidyltransferase activity
O0R52_08910	COG0726	polysaccharide deacetylase
O0R52_08915	COG0612	Peptidase, M16
O0R52_08920	COG1873	PFAM PRC-barrel domain
O0R52_08925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O0R52_08930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O0R52_08935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O0R52_08940	COG0527	aspartate kinase activity
O0R52_08945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O0R52_08950	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O0R52_08955	COG0740	serine-type endopeptidase activity
O0R52_08965	COG4980	gas vesicle protein
O0R52_08965	COG1674	ftsk spoiiie
O0R52_08970	COG2188	Transcriptional regulator
O0R52_08975	COG2814	Major facilitator Superfamily
O0R52_08980	COG0612	Peptidase, M16
O0R52_08985	COG0612	Peptidase, M16
O0R52_08990	COG0300	oxidoreductase activity
O0R52_09005	COG1426	Protein conserved in bacteria
O0R52_09010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O0R52_09015	COG1546	Belongs to the CinA family
O0R52_09015	COG1058	Belongs to the CinA family
O0R52_09020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O0R52_09025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O0R52_09030	COG1418	mRNA catabolic process
O0R52_09035	COG1692	metallophosphoesterase
O0R52_09040	COG2359	stage V sporulation protein S
O0R52_09045	COG1063	alcohol dehydrogenase
O0R52_09050	COG0156	8-amino-7-oxononanoate synthase activity
O0R52_09055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O0R52_09060	COG4550	Control of competence regulator ComK, YlbF/YmcA
O0R52_09070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O0R52_09075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O0R52_09130	COG3226	Transcriptional regulator
O0R52_09135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R52_09140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O0R52_09145	COG3321	synthase
O0R52_09150	COG2070	2-Nitropropane dioxygenase
O0R52_09150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O0R52_09155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R52_09160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O0R52_09165	COG3425	synthase
O0R52_09170	COG1024	Enoyl-CoA hydratase
O0R52_09175	COG1024	Enoyl-CoA hydratase
O0R52_09180	COG0318	PFAM AMP-dependent synthetase and ligase
O0R52_09180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_09180	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_09180	COG3321	synthase
O0R52_09180	COG0300	oxidoreductase activity
O0R52_09185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R52_09185	COG0300	oxidoreductase activity
O0R52_09185	COG3321	synthase
O0R52_09185	COG4221	oxidoreductase activity
O0R52_09190	COG3321	synthase
O0R52_09190	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_09190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_09190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O0R52_09190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R52_09195	COG3321	synthase
O0R52_09195	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_09195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_09195	COG4221	oxidoreductase activity
O0R52_09200	COG3321	synthase
O0R52_09200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R52_09200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O0R52_09200	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
O0R52_09205	COG2124	cytochrome p450
O0R52_09215	COG1404	Belongs to the peptidase S8 family
O0R52_09225	COG4195	phage-related replication protein
O0R52_09230	COG1764	response to oxidative stress
O0R52_09255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O0R52_09260	COG1923	regulation of RNA biosynthetic process
O0R52_09280	COG1780	Probably involved in ribonucleotide reductase function
O0R52_09285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O0R52_09290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O0R52_09295	COG4112	unkown
O0R52_09300	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R52_09305	COG1131	(ABC) transporter
O0R52_09310	COG0464	growth
O0R52_09315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O0R52_09320	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
O0R52_09325	COG0789	Transcriptional regulator
O0R52_09330	COG0174	glutamine synthetase
O0R52_09375	COG3645	SOS response
O0R52_09375	COG3646	Phage regulatory protein
O0R52_09400	COG0305	Participates in initiation and elongation during chromosome replication
O0R52_09520	COG3953	SLT domain
O0R52_09520	COG5280	Phage tail tape measure protein TP901
O0R52_09530	COG1705	Flagellar rod assembly protein muramidase FlgJ
O0R52_09535	COG5434	Belongs to the glycosyl hydrolase 28 family
O0R52_09560	COG4824	toxin secretion phage lysis holin
O0R52_09565	COG5632	N-Acetylmuramoyl-L-alanine amidase
O0R52_09565	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_09565	COG1388	LysM domain
O0R52_09575	COG5444	nuclease activity
O0R52_09580	COG0457	Tetratricopeptide repeat
O0R52_09610	COG2273	Hydrolase Family 16
O0R52_09670	COG0726	polysaccharide deacetylase
O0R52_09705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O0R52_09710	COG2720	vancomycin resistance protein
O0R52_09715	COG3739	integral membrane protein
O0R52_09720	COG3655	Transcriptional regulator
O0R52_09730	COG2135	peptidase activity
O0R52_09735	COG5434	Belongs to the glycosyl hydrolase 28 family
O0R52_09755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O0R52_09765	COG3832	glyoxalase III activity
O0R52_09795	COG4195	phage-related replication protein
O0R52_09815	COG0346	lactoylglutathione lyase activity
O0R52_09825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O0R52_09830	COG1388	LysM domain
O0R52_09835	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O0R52_09840	COG4224	UPF0291 protein
O0R52_09845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O0R52_09855	COG3763	UPF0154 protein
O0R52_09865	COG0785	Cytochrome C biogenesis protein
O0R52_09870	COG2201	protein-glutamate methylesterase activity
O0R52_09875	COG4846	Membrane protein involved in cytochrome C biogenesis
O0R52_09885	COG0071	Belongs to the small heat shock protein (HSP20) family
O0R52_09900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
O0R52_09905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R52_09925	COG0824	Thioesterase
O0R52_09935	COG4841	protein insertion into membrane
O0R52_09940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O0R52_09945	COG1832	CoA-binding protein
O0R52_09950	COG0187	DNA topoisomerase II activity
O0R52_09955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O0R52_09970	COG1115	amino acid carrier protein
O0R52_09975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
O0R52_10015	COG2246	polysaccharide biosynthetic process
O0R52_10020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O0R52_10025	COG0586	Pfam SNARE associated Golgi protein
O0R52_10030	COG2404	hydrolase activity, acting on ester bonds
O0R52_10035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O0R52_10040	COG1024	Enoyl-CoA hydratase
O0R52_10045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O0R52_10050	COG0511	ligase activity, forming carbon-carbon bonds
O0R52_10055	COG0439	Biotin carboxylase
O0R52_10060	COG0318	PFAM AMP-dependent synthetase and ligase
O0R52_10065	COG1960	acyl-CoA dehydrogenase activity
O0R52_10075	COG1649	PFAM Uncharacterised BCR, COG1649
O0R52_10085	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
O0R52_10085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_10090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_10095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_10100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_10105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_10110	COG2027	D-alanyl-D-alanine carboxypeptidase
O0R52_10115	COG2017	converts alpha-aldose to the beta-anomer
O0R52_10120	COG0534	Mate efflux family protein
O0R52_10135	COG0582	viral genome integration into host DNA
O0R52_10140	COG0166	Belongs to the GPI family
O0R52_10145	COG0405	Gamma-glutamyltransferase
O0R52_10150	COG0583	DNA-binding transcription factor activity
O0R52_10155	COG0604	alcohol dehydrogenase
O0R52_10160	COG0493	'glutamate synthase
O0R52_10165	COG0067	glutamate synthase
O0R52_10165	COG0069	glutamate synthase activity
O0R52_10165	COG0070	glutamate synthase
O0R52_10170	COG0583	DNA-binding transcription factor activity
O0R52_10175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O0R52_10195	COG0300	oxidoreductase activity
O0R52_10200	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
O0R52_10210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R52_10225	COG1131	(ABC) transporter
O0R52_10235	COG2814	Major facilitator Superfamily
O0R52_10240	COG1070	Carbohydrate kinase
O0R52_10245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O0R52_10250	COG0243	molybdopterin cofactor binding
O0R52_10260	COG4305	rare lipoprotein A
O0R52_10265	COG3619	membrane
O0R52_10275	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_10320	COG2814	Major facilitator Superfamily
O0R52_10330	COG1231	oxidoreductase activity
O0R52_10340	COG1070	Carbohydrate kinase
O0R52_10355	COG3507	Belongs to the glycosyl hydrolase 43 family
O0R52_10360	COG2211	Major facilitator Superfamily
O0R52_10385	COG3397	chitin binding
O0R52_10390	COG2318	DinB family
O0R52_10400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R52_10415	COG0135	phosphoribosylanthranilate isomerase activity
O0R52_10465	COG0457	Tetratricopeptide repeat
O0R52_10480	COG3848	Pyruvate phosphate dikinase
O0R52_10480	COG0574	Belongs to the PEP-utilizing enzyme family
O0R52_10490	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_10495	COG1733	regulation of RNA biosynthetic process
O0R52_10500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O0R52_10505	COG2207	Transcriptional regulator
O0R52_10505	COG0662	Cupin 2, conserved barrel domain protein
O0R52_10510	COG0456	acetyltransferase
O0R52_10515	COG1309	transcriptional regulator
O0R52_10520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R52_10525	COG3708	Transcriptional regulator
O0R52_10530	COG2378	regulation of single-species biofilm formation
O0R52_10540	COG0640	Transcriptional regulator
O0R52_10545	COG0741	lytic transglycosylase activity
O0R52_10550	COG2322	membrane
O0R52_10565	COG1619	proteins homologs of microcin C7 resistance protein MccF
O0R52_10570	COG3239	Fatty acid desaturase
O0R52_10575	COG4585	Histidine kinase
O0R52_10580	COG2197	response regulator
O0R52_10595	COG3584	3D domain protein
O0R52_10595	COG1388	LysM domain
O0R52_10600	COG0514	ATP-dependent DNA helicase (RecQ)
O0R52_10610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O0R52_10615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O0R52_10630	COG1012	belongs to the aldehyde dehydrogenase family
O0R52_10635	COG1657	PFAM Prenyltransferase squalene oxidase
O0R52_10640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O0R52_10645	COG0733	neurotransmitter:sodium symporter activity
O0R52_10650	COG0385	Bile acid
O0R52_10655	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0R52_10660	COG0567	Dehydrogenase, E1 component
O0R52_10665	COG4548	von Willebrand factor, type A
O0R52_10670	COG0714	Associated with various cellular activities
O0R52_10675	COG2032	superoxide dismutase activity
O0R52_10680	COG1388	LysM domain
O0R52_10680	COG0791	NLP P60 protein
O0R52_10685	COG1819	glycosyl
O0R52_10690	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
O0R52_10695	COG0534	Mate efflux family protein
O0R52_10700	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R52_10705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O0R52_10710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O0R52_10720	COG2962	Rard protein
O0R52_10740	COG1942	4-Oxalocrotonate Tautomerase
O0R52_10750	COG1733	regulation of RNA biosynthetic process
O0R52_10755	COG0778	Nitroreductase
O0R52_10760	COG0400	carboxylic ester hydrolase activity
O0R52_10765	COG0346	lactoylglutathione lyase activity
O0R52_10775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O0R52_10780	COG0793	Belongs to the peptidase S41A family
O0R52_10780	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_10785	COG2226	methyltransferase
O0R52_10795	COG1876	peptidase activity
O0R52_10800	COG0813	purine-nucleoside phosphorylase activity
O0R52_10810	COG1309	transcriptional regulator
O0R52_10815	COG2814	Major facilitator Superfamily
O0R52_10835	COG0671	phosphoesterase, PA-phosphatase related
O0R52_10855	COG4479	Belongs to the UPF0346 family
O0R52_10865	COG1509	lysine 2,3-aminomutase activity
O0R52_10870	COG0456	acetyltransferase
O0R52_10875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O0R52_10880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O0R52_10885	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O0R52_10890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O0R52_10900	COG0456	acetyltransferase
O0R52_10905	COG0463	Glycosyl transferase, family 2
O0R52_10920	COG4641	Protein conserved in bacteria
O0R52_10925	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
O0R52_10940	COG3331	DNA recombination
O0R52_10950	COG0457	Tetratricopeptide repeat
O0R52_10955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R52_10965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O0R52_10970	COG2226	methyltransferase
O0R52_10975	COG2211	Major facilitator Superfamily
O0R52_11000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R52_11020	COG5444	nuclease activity
O0R52_11025	COG4282	regulation of fungal-type cell wall biogenesis
O0R52_11055	COG0577	efflux transmembrane transporter activity
O0R52_11055	COG1136	(ABC) transporter
O0R52_11075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O0R52_11080	COG1086	Polysaccharide biosynthesis protein
O0R52_11090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O0R52_11095	COG1846	Transcriptional regulator
O0R52_11100	COG0534	Mate efflux family protein
O0R52_11110	COG4698	Protein conserved in bacteria
O0R52_11115	COG2755	lipolytic protein G-D-S-L family
O0R52_11120	COG1999	signal sequence binding
O0R52_11130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O0R52_11135	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O0R52_11140	COG1272	protein, Hemolysin III
O0R52_11145	COG0204	Acyl-transferase
O0R52_11150	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O0R52_11160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O0R52_11170	COG2521	methyltransferase
O0R52_11170	COG2136	Putative SAM-dependent methyltransferase
O0R52_11180	COG0129	dihydroxy-acid dehydratase activity
O0R52_11185	COG1413	lyase activity
O0R52_11190	COG1418	mRNA catabolic process
O0R52_11195	COG0386	Belongs to the glutathione peroxidase family
O0R52_11200	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
O0R52_11205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O0R52_11215	COG1278	Cold shock
O0R52_11235	COG0328	RNA-DNA hybrid ribonuclease activity
O0R52_11240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
O0R52_11245	COG0328	RNA-DNA hybrid ribonuclease activity
O0R52_11255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O0R52_11270	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O0R52_11280	COG1755	Isoprenylcysteine carboxyl methyltransferase
O0R52_11285	COG3424	synthase
O0R52_11290	COG2233	PERMEase
O0R52_11295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O0R52_11300	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O0R52_11310	COG0800	Aldolase
O0R52_11315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O0R52_11320	COG1609	Transcriptional regulator
O0R52_11325	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
O0R52_11330	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_11335	COG1199	ATP-dependent helicase activity
O0R52_11350	COG0116	Belongs to the methyltransferase superfamily
O0R52_11365	COG4474	Belongs to the UPF0398 family
O0R52_11380	COG3359	exonuclease
O0R52_11385	COG1111	helicase
O0R52_11385	COG1205	dead DEAH box helicase
O0R52_11390	COG2190	(PTS) system
O0R52_11395	COG0071	Belongs to the small heat shock protein (HSP20) family
O0R52_11430	COG3331	DNA recombination
O0R52_11435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O0R52_11435	COG4499	WXG100 protein secretion system (Wss), protein YukC
O0R52_11445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O0R52_11450	COG3935	DnaD domain protein
O0R52_11455	COG0017	Asparaginyl-tRNA synthetase
O0R52_11460	COG0436	Aminotransferase
O0R52_11465	COG5353	protein conserved in bacteria
O0R52_11475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O0R52_11475	COG1199	ATP-dependent helicase activity
O0R52_11480	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
O0R52_11485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O0R52_11490	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O0R52_11495	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
O0R52_11495	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
O0R52_11500	COG0617	tRNA 3'-terminal CCA addition
O0R52_11505	COG0438	transferase activity, transferring glycosyl groups
O0R52_11510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O0R52_11515	COG1803	Methylglyoxal synthase
O0R52_11520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O0R52_11525	COG1694	Mazg nucleotide pyrophosphohydrolase
O0R52_11530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R52_11540	COG4347	Protein of unknown function (DUF1405)
O0R52_11545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O0R52_11545	COG2010	Cytochrome c
O0R52_11550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O0R52_11555	COG0723	plastoquinol--plastocyanin reductase activity
O0R52_11565	COG5582	Belongs to the UPF0302 family
O0R52_11570	COG0457	Tetratricopeptide repeat
O0R52_11575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O0R52_11580	COG0287	Prephenate dehydrogenase
O0R52_11585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O0R52_11590	COG0159	tryptophan synthase activity
O0R52_11595	COG0133	tryptophan synthase activity
O0R52_11600	COG0135	phosphoribosylanthranilate isomerase activity
O0R52_11610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O0R52_11615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O0R52_11620	COG4401	Chorismate mutase type I
O0R52_11625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O0R52_11630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O0R52_11635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O0R52_11640	COG0105	UTP biosynthetic process
O0R52_11645	COG0142	geranyltranstransferase activity
O0R52_11650	COG2226	methyltransferase
O0R52_11655	COG0142	geranyltranstransferase activity
O0R52_11665	COG0302	gtp cyclohydrolase
O0R52_11670	COG0776	regulation of translation
O0R52_11675	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O0R52_11690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O0R52_11695	COG1160	GTP binding
O0R52_11720	COG1304	FMN binding
O0R52_11725	COG0539	negative regulation of cytoplasmic translation
O0R52_11730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O0R52_11740	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
O0R52_11745	COG2959	enzyme of heme biosynthesis
O0R52_11750	COG3773	Cell wall hydrolase
O0R52_11750	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_11755	COG2339	peptidase activity
O0R52_11760	COG0492	ferredoxin-NADP+ reductase activity
O0R52_11765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O0R52_11770	COG4862	establishment of competence for transformation
O0R52_11775	COG1408	metallophosphoesterase
O0R52_11785	COG1388	LysM domain
O0R52_11790	COG1266	CAAX protease self-immunity
O0R52_11795	COG0514	ATP-dependent DNA helicase (RecQ)
O0R52_11800	COG4955	Helix-turn-helix domain
O0R52_11805	COG1141	Ferredoxin
O0R52_11810	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
O0R52_11815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O0R52_11820	COG0710	3-dehydroquinate dehydratase activity
O0R52_11830	COG1595	DNA-templated transcription, initiation
O0R52_11835	COG5002	protein histidine kinase activity
O0R52_11840	COG0745	RESPONSE REGULATOR receiver
O0R52_11845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O0R52_11850	COG1333	cytochrome c biogenesis protein
O0R52_11855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R52_11860	COG1187	pseudouridine synthase activity
O0R52_11865	COG0700	Nucleoside recognition
O0R52_11870	COG2715	membrane protein required for spore maturation
O0R52_11875	COG1686	Belongs to the peptidase S11 family
O0R52_11885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O0R52_11890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
O0R52_11900	COG1547	Domain of unknown function (DUF309)
O0R52_11905	COG0456	acetyltransferase
O0R52_11910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O0R52_11915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O0R52_11915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O0R52_11920	COG0307	riboflavin synthase, alpha
O0R52_11925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O0R52_11925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O0R52_11935	COG0681	Belongs to the peptidase S26 family
O0R52_11940	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
O0R52_11945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O0R52_11950	COG4086	secreted protein
O0R52_11955	COG0019	diaminopimelate decarboxylase activity
O0R52_11960	COG0697	spore germination
O0R52_11975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O0R52_11995	COG1191	sigma factor activity
O0R52_12000	COG2172	sigma factor antagonist activity
O0R52_12005	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R52_12010	COG1686	Belongs to the peptidase S11 family
O0R52_12015	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
O0R52_12020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
O0R52_12025	COG4974	Belongs to the 'phage' integrase family
O0R52_12035	COG0735	belongs to the Fur family
O0R52_12040	COG1300	Membrane
O0R52_12050	COG0281	malic enzyme
O0R52_12055	COG1757	Na H antiporter
O0R52_12060	COG1027	Aspartate ammonia-lyase
O0R52_12065	COG0252	asparaginase activity
O0R52_12070	COG1396	sequence-specific DNA binding
O0R52_12075	COG1379	DNA repair
O0R52_12080	COG0494	nUDIX hydrolase
O0R52_12090	COG0667	Aldo Keto reductase
O0R52_12100	COG1073	alpha beta
O0R52_12110	COG4918	Iron-sulphur cluster biosynthesis
O0R52_12115	COG0456	acetyltransferase
O0R52_12115	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
O0R52_12125	COG0456	acetyltransferase
O0R52_12135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O0R52_12145	COG2211	Major facilitator Superfamily
O0R52_12160	COG1072	(Pantothenic acid kinase))
O0R52_12165	COG3048	D-serine ammonia-lyase activity
O0R52_12170	COG0300	oxidoreductase activity
O0R52_12175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R52_12180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O0R52_12185	COG4187	Peptidase family M20/M25/M40
O0R52_12190	COG1902	pentaerythritol trinitrate reductase activity
O0R52_12195	COG0596	Alpha beta hydrolase
O0R52_12205	COG1234	tRNA 3'-trailer cleavage
O0R52_12210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O0R52_12220	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O0R52_12225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O0R52_12235	COG0706	membrane insertase activity
O0R52_12240	COG3361	conserved protein (COG2071)
O0R52_12245	COG2195	Cleaves the N-terminal amino acid of tripeptides
O0R52_12250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O0R52_12255	COG0346	lactoylglutathione lyase activity
O0R52_12265	COG1376	ErfK ybiS ycfS ynhG family protein
O0R52_12270	COG4129	membrane
O0R52_12275	COG1126	abc transporter atp-binding protein
O0R52_12280	COG0765	amino acid transport
O0R52_12285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R52_12295	COG1597	lipid kinase activity
O0R52_12300	COG2814	Major facilitator Superfamily
O0R52_12305	COG0789	Transcriptional regulator
O0R52_12305	COG4978	Transcriptional regulator
O0R52_12310	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0R52_12315	COG0022	dehydrogenase e1 component
O0R52_12320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O0R52_12325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O0R52_12330	COG3426	butyrate kinase activity
O0R52_12335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O0R52_12340	COG0280	phosphate acetyltransferase
O0R52_12345	COG3829	transcription factor binding
O0R52_12345	COG3290	protein histidine kinase activity
O0R52_12355	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O0R52_12360	COG2079	MmgE PrpD family protein
O0R52_12365	COG0372	Belongs to the citrate synthase family
O0R52_12370	COG1960	acyl-CoA dehydrogenase activity
O0R52_12375	COG1250	3-hydroxyacyl-CoA dehydrogenase
O0R52_12380	COG0183	Belongs to the thiolase family
O0R52_12385	COG0584	glycerophosphoryl diester phosphodiesterase
O0R52_12390	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R52_12405	COG1902	pentaerythritol trinitrate reductase activity
O0R52_12410	COG0745	RESPONSE REGULATOR receiver
O0R52_12415	COG0750	zinc metalloprotease
O0R52_12420	COG0497	DNA recombination
O0R52_12425	COG1438	arginine binding
O0R52_12430	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
O0R52_12435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O0R52_12440	COG0142	geranyltranstransferase activity
O0R52_12445	COG1722	exodeoxyribonuclease VII activity
O0R52_12450	COG1570	exodeoxyribonuclease VII activity
O0R52_12455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O0R52_12460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O0R52_12465	COG1302	Protein conserved in bacteria
O0R52_12470	COG0439	Biotin carboxylase
O0R52_12475	COG0511	ligase activity, forming carbon-carbon bonds
O0R52_12515	COG3854	ATPases associated with a variety of cellular activities
O0R52_12525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O0R52_12530	COG0006	proline dipeptidase activity
O0R52_12535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O0R52_12545	COG3872	metal-dependent enzyme
O0R52_12555	COG1752	Esterase of the alpha-beta hydrolase superfamily
O0R52_12560	COG1321	iron dependent repressor
O0R52_12565	COG0095	Lipoate-protein ligase
O0R52_12570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O0R52_12575	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O0R52_12580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O0R52_12585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O0R52_12590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O0R52_12605	COG1396	sequence-specific DNA binding
O0R52_12615	COG0681	Belongs to the peptidase S26 family
O0R52_12640	COG4940	Competence protein ComGF
O0R52_12650	COG4970	Tfp pilus assembly protein FimT
O0R52_12655	COG4537	Required for transformation and DNA binding
O0R52_12660	COG1459	type II secretion system
O0R52_12665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O0R52_12670	COG0517	IMP dehydrogenase activity
O0R52_12675	COG0598	Magnesium transport protein CorA
O0R52_12685	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R52_12695	COG1393	Belongs to the ArsC family
O0R52_12705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R52_12715	COG0011	TIGRFAM Protein of
O0R52_12725	COG2866	Carboxypeptidase
O0R52_12730	COG1368	sulfuric ester hydrolase activity
O0R52_12735	COG1940	carbohydrate kinase activity
O0R52_12740	COG4483	Protein conserved in bacteria
O0R52_12745	COG0457	Tetratricopeptide repeat
O0R52_12745	COG0705	Rhomboid family
O0R52_12755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O0R52_12765	COG0438	transferase activity, transferring glycosyl groups
O0R52_12780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O0R52_12785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O0R52_12790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O0R52_12795	COG0581	inorganic phosphate transmembrane transporter activity
O0R52_12800	COG0573	inorganic phosphate transmembrane transporter activity
O0R52_12805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O0R52_12810	COG0768	penicillin binding
O0R52_12815	COG0477	Major facilitator Superfamily
O0R52_12820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O0R52_12825	COG2839	Protein conserved in bacteria
O0R52_12830	COG5521	maltodextrose utilization protein MalA
O0R52_12835	COG1388	LysM domain
O0R52_12840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O0R52_12845	COG4709	membrane
O0R52_12850	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
O0R52_12855	COG0735	belongs to the Fur family
O0R52_12860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R52_12870	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O0R52_12875	COG0513	Belongs to the DEAD box helicase family
O0R52_12885	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O0R52_12890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O0R52_12895	COG2384	SAM-dependent methyltransferase
O0R52_12900	COG2010	Cytochrome c
O0R52_12905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O0R52_12910	COG0358	DNA primase activity
O0R52_12915	COG1671	Belongs to the UPF0178 family
O0R52_12920	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O0R52_12925	COG0517	IMP dehydrogenase activity
O0R52_12930	COG0751	glycine-tRNA ligase activity
O0R52_12935	COG0752	glycyl-tRNA synthetase alpha subunit
O0R52_12940	COG1381	Involved in DNA repair and RecF pathway recombination
O0R52_12950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O0R52_12955	COG0295	cytidine deaminase activity
O0R52_12960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O0R52_12965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O0R52_12970	COG1480	7TM receptor with intracellular HD hydrolase
O0R52_12975	COG1702	phosphate starvation-inducible protein PhoH
O0R52_12980	COG0561	phosphatase activity
O0R52_12995	COG4864	UPF0365 protein
O0R52_13000	COG1030	water channel activity
O0R52_13005	COG1610	YqeY-like protein
O0R52_13015	COG1283	sodium-dependent phosphate transmembrane transporter activity
O0R52_13020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O0R52_13025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O0R52_13030	COG2264	protein methyltransferase activity
O0R52_13035	COG0484	heat shock protein binding
O0R52_13045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O0R52_13050	COG1420	regulation of RNA biosynthetic process
O0R52_13055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O0R52_13060	COG0481	GTPase activity
O0R52_13070	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R52_13075	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
O0R52_13085	COG1466	dna polymerase III delta subunit
O0R52_13100	COG2333	competence protein COMEC
O0R52_13100	COG0658	competence protein
O0R52_13105	COG2131	deaminase
O0R52_13110	COG1596	polysaccharide export
O0R52_13110	COG1555	photosystem II stabilization
O0R52_13115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O0R52_13120	COG2226	methyltransferase
O0R52_13125	COG0799	negative regulation of ribosome biogenesis
O0R52_13130	COG1713	HD superfamily hydrolase involved in NAD metabolism
O0R52_13135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O0R52_13140	COG1534	Rna-binding protein
O0R52_13145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O0R52_13150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O0R52_13155	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
O0R52_13170	COG2755	lipolytic protein G-D-S-L family
O0R52_13175	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_13175	COG5632	N-Acetylmuramoyl-L-alanine amidase
O0R52_13180	COG0398	Pfam SNARE associated Golgi protein
O0R52_13185	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
O0R52_13195	COG3209	COG3209 Rhs family protein
O0R52_13215	COG2323	membrane
O0R52_13220	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
O0R52_13225	COG0730	response to heat
O0R52_13230	COG0425	Belongs to the sulfur carrier protein TusA family
O0R52_13235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R52_13235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O0R52_13240	COG2210	Belongs to the sulfur carrier protein TusA family
O0R52_13245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O0R52_13245	COG0425	Belongs to the sulfur carrier protein TusA family
O0R52_13250	COG1054	Belongs to the UPF0176 family
O0R52_13255	COG2210	Belongs to the sulfur carrier protein TusA family
O0R52_13260	COG1937	Protein conserved in bacteria
O0R52_13280	COG0662	Cupin 2, conserved barrel domain protein
O0R52_13305	COG5444	nuclease activity
O0R52_13330	COG3620	sequence-specific DNA binding
O0R52_13340	COG2856	Zn peptidase
O0R52_13360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O0R52_13365	COG0798	PFAM Bile acid sodium symporter
O0R52_13370	COG0346	lactoylglutathione lyase activity
O0R52_13375	COG0640	Transcriptional regulator
O0R52_13395	COG0604	alcohol dehydrogenase
O0R52_13405	COG2315	Protein conserved in bacteria
O0R52_13410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O0R52_13415	COG0457	Tetratricopeptide repeat
O0R52_13420	COG5444	nuclease activity
O0R52_13430	COG1388	LysM domain
O0R52_13430	COG5632	N-Acetylmuramoyl-L-alanine amidase
O0R52_13430	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_13435	COG4824	toxin secretion phage lysis holin
O0R52_13450	COG1794	racemase activity, acting on amino acids and derivatives
O0R52_13470	COG0563	adenylate kinase activity
O0R52_13475	COG2856	Zn peptidase
O0R52_13490	COG3223	Belongs to the PsiE family
O0R52_13495	COG5002	protein histidine kinase activity
O0R52_13495	COG0642	Histidine kinase
O0R52_13500	COG0745	RESPONSE REGULATOR receiver
O0R52_13505	COG2311	Membrane
O0R52_13510	COG0454	-acetyltransferase
O0R52_13530	COG5002	protein histidine kinase activity
O0R52_13535	COG0745	RESPONSE REGULATOR receiver
O0R52_13545	COG2732	(Barnase) inhibitor
O0R52_13570	COG1725	Transcriptional regulator
O0R52_13605	COG3443	Belongs to the bacterial solute-binding protein 9 family
O0R52_13610	COG4991	sh3 domain protein
O0R52_13615	COG4991	sh3 domain protein
O0R52_13645	COG0693	protein deglycase activity
O0R52_13650	COG1621	beta-fructofuranosidase activity
O0R52_13655	COG3716	PTS system mannose fructose sorbose family IID component
O0R52_13660	COG3715	PTS system
O0R52_13665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R52_13670	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R52_13675	COG3933	PFAM sigma-54 factor interaction domain-containing protein
O0R52_13675	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O0R52_13685	COG1280	lysine exporter protein (LysE YggA)
O0R52_13690	COG1378	Sugar-specific transcriptional regulator TrmB
O0R52_13695	COG1595	DNA-templated transcription, initiation
O0R52_13705	COG2755	lipolytic protein G-D-S-L family
O0R52_13705	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O0R52_13715	COG2124	cytochrome p450
O0R52_13715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O0R52_13720	COG1309	transcriptional regulator
O0R52_13725	COG2226	methyltransferase
O0R52_13740	COG2116	formate transmembrane transporter activity
O0R52_13745	COG5609	conserved protein (DUF2294)
O0R52_13750	COG3383	formate dehydrogenase (NAD+) activity
O0R52_13755	COG2427	Protein of unknown function (DUF1641)
O0R52_13765	COG0626	cystathionine gamma-synthase activity
O0R52_13770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O0R52_13775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O0R52_13780	COG2226	methyltransferase
O0R52_13795	COG0768	penicillin binding
O0R52_13800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O0R52_13805	COG0572	uridine kinase
O0R52_13810	COG0826	peptidase U32
O0R52_13815	COG0826	peptidase U32
O0R52_13820	COG4122	O-methyltransferase activity
O0R52_13825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O0R52_13830	COG3906	Belongs to the UPF0473 family
O0R52_13835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O0R52_13840	COG4472	Bacterial protein of unknown function (DUF965)
O0R52_13845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O0R52_13850	COG0628	permease
O0R52_13855	COG1126	abc transporter atp-binding protein
O0R52_13860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R52_13865	COG0765	amino acid transport
O0R52_13870	COG0765	amino acid transport
O0R52_13885	COG3881	PFAM PRC-barrel domain
O0R52_13890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O0R52_13895	COG0457	Tetratricopeptide repeat
O0R52_13900	COG0482	sulfurtransferase activity
O0R52_13905	COG1104	cysteine desulfurase activity
O0R52_13910	COG1959	2 iron, 2 sulfur cluster binding
O0R52_13915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O0R52_13920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O0R52_13930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O0R52_13935	COG0124	histidyl-tRNA synthetase
O0R52_13945	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R52_13945	COG3103	Sh3 type 3 domain protein
O0R52_13945	COG4991	sh3 domain protein
O0R52_13950	COG1490	D-aminoacyl-tRNA deacylase activity
O0R52_13955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O0R52_13960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O0R52_13965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O0R52_13965	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
O0R52_13970	COG5416	Lipopolysaccharide assembly protein A domain
O0R52_13975	COG0490	domain, Protein
O0R52_13980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O0R52_13980	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O0R52_13990	COG2244	polysaccharide biosynthetic process
O0R52_13995	COG2323	membrane
O0R52_14005	COG1862	Preprotein translocase
O0R52_14010	COG0343	queuine tRNA-ribosyltransferase activity
O0R52_14015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O0R52_14025	COG2255	four-way junction helicase activity
O0R52_14030	COG0632	four-way junction helicase activity
O0R52_14040	COG2814	Major facilitator Superfamily
O0R52_14045	COG0673	inositol 2-dehydrogenase activity
O0R52_14050	COG2112	serine threonine protein kinase
O0R52_14065	COG1115	amino acid carrier protein
O0R52_14070	COG0217	transcriptional regulatory protein
O0R52_14080	COG1388	LysM domain
O0R52_14085	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O0R52_14090	COG0157	Belongs to the NadC ModD family
O0R52_14095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O0R52_14100	COG1104	cysteine desulfurase activity
O0R52_14105	COG1827	regulation of RNA biosynthetic process
O0R52_14110	COG0077	Prephenate dehydratase
O0R52_14115	COG4492	Belongs to the UPF0735 family
O0R52_14120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O0R52_14125	COG3290	protein histidine kinase activity
O0R52_14135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O0R52_14140	COG2868	ribosomal protein
O0R52_14145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O0R52_14150	COG1994	Peptidase M50
O0R52_14155	COG0739	heme binding
O0R52_14160	COG2894	cell division
O0R52_14165	COG0850	regulation of cytokinetic process
O0R52_14170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
O0R52_14180	COG1077	Cell shape determining protein MreB Mrl
O0R52_14185	COG2003	Belongs to the UPF0758 family
O0R52_14190	COG0424	maF-like protein
O0R52_14200	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O0R52_14205	COG0285	dihydrofolate synthase activity
O0R52_14210	COG0525	valine-tRNA ligase activity
O0R52_14220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O0R52_14225	COG1388	LysM domain
O0R52_14230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O0R52_14235	COG0113	porphobilinogen synthase activity
O0R52_14240	COG1587	Uroporphyrinogen-III synthase
O0R52_14245	COG0181	hydroxymethylbilane synthase activity
O0R52_14250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O0R52_14255	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O0R52_14265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O0R52_14270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O0R52_14275	COG0470	DNA polymerase III
O0R52_14275	COG1067	ATP-dependent peptidase activity
O0R52_14280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O0R52_14285	COG0544	peptidyl-prolyl cis-trans isomerase activity
O0R52_14290	COG0457	Tetratricopeptide repeat
O0R52_14290	COG1477	protein flavinylation
O0R52_14295	COG0066	3-isopropylmalate dehydratase activity
O0R52_14300	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O0R52_14305	COG0473	3-isopropylmalate dehydrogenase activity
O0R52_14310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O0R52_14315	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O0R52_14320	COG0440	acetolactate synthase activity
O0R52_14325	COG0028	Belongs to the TPP enzyme family
O0R52_14335	COG0454	-acetyltransferase
O0R52_14345	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
O0R52_14355	COG0622	Phosphoesterase
O0R52_14360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O0R52_14365	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O0R52_14370	COG5401	PFAM Sporulation and spore germination
O0R52_14375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O0R52_14380	COG1846	Transcriptional regulator
O0R52_14385	COG2197	response regulator
O0R52_14390	COG0824	Thioesterase
O0R52_14395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O0R52_14400	COG1053	succinate dehydrogenase
O0R52_14405	COG2009	succinate dehydrogenase
O0R52_14410	COG1719	4-vinyl reductase, 4VR
O0R52_14415	COG0527	aspartate kinase activity
O0R52_14420	COG0322	excinuclease ABC activity
O0R52_14425	COG3118	belongs to the thioredoxin family
O0R52_14430	COG3534	alpha-L-arabinofuranosidase
O0R52_14435	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
O0R52_14440	COG2086	electron transfer activity
O0R52_14445	COG1024	Enoyl-CoA hydratase
O0R52_14450	COG1309	transcriptional regulator
O0R52_14455	COG0318	PFAM AMP-dependent synthetase and ligase
O0R52_14460	COG3766	membrane
O0R52_14465	COG1193	negative regulation of DNA recombination
O0R52_14470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O0R52_14470	COG1796	DNA polymerase
O0R52_14475	COG1286	toxin biosynthetic process
O0R52_14480	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
O0R52_14485	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O0R52_14490	COG0072	phenylalanine-tRNA ligase activity
O0R52_14490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O0R52_14495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O0R52_14505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O0R52_14515	COG3835	regulator
O0R52_14520	COG0277	FAD linked oxidase domain protein
O0R52_14525	COG0247	lactate metabolic process
O0R52_14530	COG0346	lactoylglutathione lyase activity
O0R52_14535	COG1966	Carbon starvation protein
O0R52_14550	COG1695	Transcriptional regulator
O0R52_14555	COG3534	alpha-L-arabinofuranosidase
O0R52_14560	COG0395	ABC-type sugar transport system, permease component
O0R52_14565	COG1175	transmembrane transport
O0R52_14570	COG1653	transport
O0R52_14575	COG0371	Dehydrogenase
O0R52_14580	COG0647	UMP catabolic process
O0R52_14585	COG0235	Class ii aldolase
O0R52_14590	COG1069	ribulokinase activity
O0R52_14595	COG2160	L-arabinose isomerase activity
O0R52_14600	COG3507	Belongs to the glycosyl hydrolase 43 family
O0R52_14605	COG1363	Peptidase, m42
O0R52_14615	COG3326	Membrane
O0R52_14620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O0R52_14625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O0R52_14630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O0R52_14645	COG1346	cytolysis
O0R52_14650	COG1380	Effector of murein hydrolase LrgA
O0R52_14655	COG3279	Response regulator of the LytR AlgR family
O0R52_14660	COG3275	phosphorelay sensor kinase activity
O0R52_14665	COG1011	Hydrolase
O0R52_14670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O0R52_14680	COG0398	Pfam SNARE associated Golgi protein
O0R52_14685	COG1484	DNA-dependent DNA replication
O0R52_14690	COG3611	Membrane attachment protein
O0R52_14695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O0R52_14700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
O0R52_14705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O0R52_14710	COG1733	regulation of RNA biosynthetic process
O0R52_14715	COG2814	Major facilitator Superfamily
O0R52_14720	COG0656	L-ascorbic acid biosynthetic process
O0R52_14725	COG0237	dephospho-CoA kinase activity
O0R52_14735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O0R52_14740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O0R52_14740	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O0R52_14745	COG5002	protein histidine kinase activity
O0R52_14750	COG0745	RESPONSE REGULATOR receiver
O0R52_14755	COG0039	L-malate dehydrogenase activity
O0R52_14760	COG0538	isocitrate dehydrogenase activity
O0R52_14765	COG0372	Belongs to the citrate synthase family
O0R52_14770	COG2707	UPF0756 membrane protein
O0R52_14775	COG0628	permease
O0R52_14780	COG3030	protein affecting phage T7 exclusion by the F plasmid
O0R52_14785	COG0469	pyruvate kinase activity
O0R52_14790	COG0205	6-phosphofructokinase activity
O0R52_14795	COG0825	malonyl-CoA metabolic process
O0R52_14800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O0R52_14805	COG0281	malic enzyme
O0R52_14810	COG0587	DNA-directed DNA polymerase activity
O0R52_14830	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O0R52_14840	COG4109	DRTGG domain
O0R52_14845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O0R52_14850	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_14860	COG0165	Argininosuccinate lyase
O0R52_14865	COG0137	argininosuccinate synthase activity
O0R52_14870	COG0521	Mo-molybdopterin cofactor biosynthetic process
O0R52_14875	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O0R52_14880	COG0827	DNA restriction-modification system
O0R52_14885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
O0R52_14890	COG3874	Sporulation protein YtfJ
O0R52_14900	COG1714	RDD family
O0R52_14905	COG0616	signal peptide processing
O0R52_14910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O0R52_14915	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O0R52_14920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O0R52_14930	COG0301	tRNA thio-modification
O0R52_14935	COG1104	cysteine desulfurase activity
O0R52_14940	COG1114	Component of the transport system for branched-chain amino acids
O0R52_14945	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
O0R52_14950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O0R52_14955	COG1309	transcriptional regulator
O0R52_14960	COG1956	GAF domain-containing protein
O0R52_14965	COG2199	diguanylate cyclase activity
O0R52_14965	COG2203	Gaf domain
O0R52_14980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O0R52_14985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O0R52_14990	COG0454	-acetyltransferase
O0R52_14995	COG0517	IMP dehydrogenase activity
O0R52_15000	COG0123	including yeast histone deacetylase and acetoin utilization protein
O0R52_15005	COG1360	Flagellar Motor Protein
O0R52_15010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O0R52_15015	COG1609	Transcriptional regulator
O0R52_15020	COG1605	Chorismate mutase
O0R52_15020	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
O0R52_15025	COG3118	belongs to the thioredoxin family
O0R52_15030	COG4980	gas vesicle protein
O0R52_15035	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
O0R52_15040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O0R52_15045	COG1674	ftsk spoiiie
O0R52_15050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O0R52_15055	COG4848	Belongs to the UPF0354 family
O0R52_15060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R52_15075	COG1363	Peptidase, m42
O0R52_15080	COG5584	Small secreted protein
O0R52_15085	COG0281	malic enzyme
O0R52_15090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R52_15095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O0R52_15105	COG0510	thiamine kinase activity
O0R52_15110	COG1523	belongs to the glycosyl hydrolase 13 family
O0R52_15115	COG1597	lipid kinase activity
O0R52_15125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
O0R52_15130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O0R52_15135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O0R52_15140	COG2252	PERMEase
O0R52_15145	COG4473	ABC transporter
O0R52_15150	COG1131	(ABC) transporter
O0R52_15155	COG1349	DNA-binding transcription factor activity
O0R52_15160	COG1187	pseudouridine synthase activity
O0R52_15165	COG2244	polysaccharide biosynthetic process
O0R52_15170	COG2081	HI0933 family
O0R52_15175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O0R52_15185	COG5578	integral membrane protein
O0R52_15190	COG0673	inositol 2-dehydrogenase activity
O0R52_15195	COG1653	transport
O0R52_15200	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
O0R52_15205	COG4209	transmembrane transport
O0R52_15210	COG2207	Transcriptional regulator
O0R52_15215	COG1653	transport
O0R52_15220	COG0395	ABC-type sugar transport system, permease component
O0R52_15225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O0R52_15230	COG2124	cytochrome p450
O0R52_15235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O0R52_15245	COG0156	8-amino-7-oxononanoate synthase activity
O0R52_15250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O0R52_15260	COG1073	alpha beta
O0R52_15265	COG1609	Transcriptional regulator
O0R52_15270	COG1653	transport
O0R52_15275	COG1175	transmembrane transport
O0R52_15280	COG0395	ABC-type sugar transport system, permease component
O0R52_15285	COG1486	melibiose metabolic process
O0R52_15290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O0R52_15295	COG0495	leucyl-tRNA aminoacylation
O0R52_15305	COG2202	Pas domain
O0R52_15305	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R52_15310	COG2814	Major facilitator Superfamily
O0R52_15315	COG2433	Pfam Transposase IS66
O0R52_15320	COG0577	efflux transmembrane transporter activity
O0R52_15325	COG1136	(ABC) transporter
O0R52_15330	COG2205	protein histidine kinase activity
O0R52_15335	COG0745	RESPONSE REGULATOR receiver
O0R52_15340	COG0577	efflux transmembrane transporter activity
O0R52_15345	COG1136	(ABC) transporter
O0R52_15360	COG1131	(ABC) transporter
O0R52_15365	COG1725	Transcriptional regulator
O0R52_15380	COG1242	4 iron, 4 sulfur cluster binding
O0R52_15385	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
O0R52_15395	COG2267	carboxylic ester hydrolase activity
O0R52_15400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O0R52_15405	COG1113	amino acid transport
O0R52_15410	COG0367	asparagine synthase
O0R52_15415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O0R52_15420	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
O0R52_15430	COG1506	peptidase
O0R52_15435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O0R52_15440	COG1116	anion transmembrane transporter activity
O0R52_15445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O0R52_15450	COG0494	nUDIX hydrolase
O0R52_15455	COG4824	toxin secretion phage lysis holin
O0R52_15460	COG0783	Belongs to the Dps family
O0R52_15475	COG1854	S-ribosylhomocysteine lyase activity
O0R52_15480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O0R52_15485	COG0288	reversible hydration of carbon dioxide
O0R52_15490	COG0254	rRNA binding
O0R52_15495	COG1271	oxidase subunit
O0R52_15500	COG1294	oxidase, subunit
O0R52_15510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O0R52_15515	COG1321	iron dependent repressor
O0R52_15515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O0R52_15520	COG1121	(ABC) transporter
O0R52_15525	COG0803	Belongs to the bacterial solute-binding protein 9 family
O0R52_15530	COG4948	Mandelate Racemase Muconate Lactonizing
O0R52_15535	COG0318	PFAM AMP-dependent synthetase and ligase
O0R52_15540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
O0R52_15545	COG0596	Alpha beta hydrolase
O0R52_15550	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O0R52_15555	COG1169	isochorismate synthase
O0R52_15560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O0R52_15565	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
O0R52_15570	COG0058	SHG alpha-glucan phosphorylase activity
O0R52_15575	COG0297	glycogen (starch) synthase activity
O0R52_15580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O0R52_15585	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O0R52_15590	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O0R52_15715	COG3859	Proton-coupled thiamine transporter YuaJ
O0R52_15720	COG1247	-acetyltransferase
O0R52_15725	COG2268	Band 7 protein
O0R52_15730	COG1585	Membrane protein implicated in regulation of membrane protease activity
O0R52_15735	COG2318	DinB family
O0R52_15745	COG1454	alcohol dehydrogenase
O0R52_15750	COG1012	belongs to the aldehyde dehydrogenase family
O0R52_15755	COG1510	regulation of RNA biosynthetic process
O0R52_15765	COG0569	domain protein
O0R52_15770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O0R52_15775	COG4682	membrane
O0R52_15780	COG1705	Flagellar rod assembly protein muramidase FlgJ
O0R52_15785	COG0477	Major facilitator Superfamily
O0R52_15790	COG5553	Cysteine dioxygenase type I
O0R52_15830	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_15830	COG5632	N-Acetylmuramoyl-L-alanine amidase
O0R52_15965	COG5484	DNA packaging
O0R52_15975	COG3677	Transposase
O0R52_16050	COG1484	DNA-dependent DNA replication
O0R52_16055	COG3935	DnaD domain protein
O0R52_16115	COG1396	sequence-specific DNA binding
O0R52_16125	COG2856	Zn peptidase
O0R52_16130	COG0582	viral genome integration into host DNA
O0R52_16140	COG1968	undecaprenyl-diphosphatase activity
O0R52_16145	COG0628	permease
O0R52_16150	COG0673	inositol 2-dehydrogenase activity
O0R52_16155	COG4806	L-rhamnose isomerase
O0R52_16160	COG3254	rhamnose metabolic process
O0R52_16165	COG1070	Carbohydrate kinase
O0R52_16170	COG1349	DNA-binding transcription factor activity
O0R52_16175	COG3347	Dehydrogenase
O0R52_16175	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_16180	COG0840	transmembrane signaling receptor activity
O0R52_16185	COG0840	transmembrane signaling receptor activity
O0R52_16190	COG0840	transmembrane signaling receptor activity
O0R52_16195	COG0840	transmembrane signaling receptor activity
O0R52_16210	COG2070	2-Nitropropane dioxygenase
O0R52_16215	COG0432	Pfam Uncharacterised protein family UPF0047
O0R52_16220	COG0366	Alpha amylase catalytic
O0R52_16225	COG1253	flavin adenine dinucleotide binding
O0R52_16230	COG2738	Putative neutral zinc metallopeptidase
O0R52_16245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O0R52_16260	COG0166	Belongs to the GPI family
O0R52_16265	COG1979	alcohol dehydrogenase
O0R52_16270	COG1979	alcohol dehydrogenase
O0R52_16275	COG2155	Conserved Protein
O0R52_16280	COG1098	S1 RNA binding domain
O0R52_16285	COG0436	Aminotransferase
O0R52_16290	COG1522	sequence-specific DNA binding
O0R52_16295	COG2267	carboxylic ester hydrolase activity
O0R52_16305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
O0R52_16310	COG2205	protein histidine kinase activity
O0R52_16320	COG5018	Exonuclease
O0R52_16330	COG2814	Major facilitator Superfamily
O0R52_16335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O0R52_16340	COG3011	Protein conserved in bacteria
O0R52_16350	COG3290	protein histidine kinase activity
O0R52_16355	COG4565	transcriptional regulatory protein
O0R52_16360	COG1744	ABC transporter substrate-binding protein PnrA-like
O0R52_16365	COG3845	ABC transporter
O0R52_16370	COG4603	Belongs to the binding-protein-dependent transport system permease family
O0R52_16375	COG1079	Belongs to the binding-protein-dependent transport system permease family
O0R52_16380	COG3493	citrate carrier protein
O0R52_16390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O0R52_16390	COG2111	Na H antiporter
O0R52_16395	COG2111	Na H antiporter
O0R52_16400	COG1006	Multisubunit Na H antiporter MnhC subunit
O0R52_16405	COG0651	ATP synthesis coupled electron transport
O0R52_16410	COG1863	multisubunit Na H antiporter MnhE subunit
O0R52_16415	COG2212	antiporter activity
O0R52_16420	COG1320	monovalent cation:proton antiporter activity
O0R52_16425	COG2050	protein possibly involved in aromatic compounds catabolism
O0R52_16430	COG2197	response regulator
O0R52_16435	COG4585	Histidine kinase
O0R52_16445	COG0142	geranyltranstransferase activity
O0R52_16460	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O0R52_16465	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
O0R52_16470	COG1335	isochorismatase
O0R52_16475	COG5506	Protein of unknown function (DUF1694)
O0R52_16490	COG0628	permease
O0R52_16500	COG1418	mRNA catabolic process
O0R52_16505	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_16515	COG1511	domain protein
O0R52_16520	COG0433	COG0433 Predicted ATPase
O0R52_16520	COG1674	ftsk spoiiie
O0R52_16525	COG4499	WXG100 protein secretion system (Wss), protein YukC
O0R52_16530	COG5417	Belongs to the EsaB family
O0R52_16535	COG4842	Belongs to the WXG100 family
O0R52_16540	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O0R52_16540	COG2508	Transcriptional regulator
O0R52_16545	COG0686	Belongs to the AlaDH PNT family
O0R52_16550	COG5634	Uncharacterized conserved protein (DUF2278)
O0R52_16555	COG3251	PFAM MbtH domain protein
O0R52_16560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_16565	COG1535	isochorismatase
O0R52_16565	COG3433	isochorismatase activity
O0R52_16570	COG1021	2,3-dihydroxybenzoate-AMP ligase
O0R52_16575	COG1169	isochorismate synthase
O0R52_16580	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_16585	COG2819	hydrolase of the alpha beta superfamily
O0R52_16590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O0R52_16595	COG1268	BioY protein
O0R52_16600	COG2056	Na+-H+ antiporter family
O0R52_16605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O0R52_16610	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
O0R52_16615	COG3584	3D domain protein
O0R52_16630	COG1252	NADH dehydrogenase
O0R52_16635	COG0492	ferredoxin-NADP+ reductase activity
O0R52_16645	COG0516	GMP reductase activity
O0R52_16650	COG0316	Belongs to the HesB IscA family
O0R52_16655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O0R52_16660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O0R52_16665	COG4844	belongs to the
O0R52_16670	COG1252	NADH dehydrogenase
O0R52_16675	COG4837	Protein of unknown function (DUF1462)
O0R52_16680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
O0R52_16685	COG4946	Tricorn protease homolog
O0R52_16685	COG1506	peptidase
O0R52_16685	COG0823	Involved in the tonB-independent uptake of proteins
O0R52_16690	COG0083	homoserine kinase activity
O0R52_16695	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O0R52_16700	COG0460	homoserine dehydrogenase
O0R52_16705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O0R52_16710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O0R52_16715	COG0647	UMP catabolic process
O0R52_16720	COG2445	Protein of unknown function DUF86
O0R52_16725	COG4470	Protein conserved in bacteria
O0R52_16740	COG0739	heme binding
O0R52_16750	COG3377	Domain of unknown function (DUF1805)
O0R52_16755	COG0737	Belongs to the 5'-nucleotidase family
O0R52_16760	COG0730	response to heat
O0R52_16765	COG1801	Protein of unknown function DUF72
O0R52_16775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O0R52_16780	COG2508	Transcriptional regulator
O0R52_16785	COG2233	PERMEase
O0R52_16790	COG2233	PERMEase
O0R52_16795	COG3195	allantoin biosynthetic process
O0R52_16795	COG3648	Uricase
O0R52_16800	COG2351	hydroxyisourate hydrolase activity
O0R52_16815	COG2080	2 iron, 2 sulfur cluster binding
O0R52_16820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O0R52_16825	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
O0R52_16830	COG2068	MobA-Related Protein
O0R52_16835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
O0R52_16840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O0R52_16845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O0R52_16850	COG2356	endonuclease I
O0R52_16855	COG3842	ATPase activity
O0R52_16860	COG2188	Transcriptional regulator
O0R52_16865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O0R52_16870	COG0395	ABC-type sugar transport system, permease component
O0R52_16875	COG1175	transmembrane transport
O0R52_16880	COG1653	transport
O0R52_16885	COG2222	sugar isomerase
O0R52_16890	COG0322	excinuclease ABC activity
O0R52_16895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O0R52_16915	COG0719	Fe-S assembly protein
O0R52_16920	COG0822	iron-sulfur transferase activity
O0R52_16925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O0R52_16930	COG0719	Fe-S assembly protein
O0R52_16935	COG0396	ATPase activity
O0R52_16945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O0R52_16950	COG1464	Belongs to the NlpA lipoprotein family
O0R52_16955	COG2011	ABC-type metal ion transport system permease component
O0R52_16960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O0R52_16970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R52_16975	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O0R52_16985	COG0509	glycine decarboxylation via glycine cleavage system
O0R52_16990	COG1393	Belongs to the ArsC family
O0R52_16995	COG1960	acyl-CoA dehydrogenase activity
O0R52_17000	COG0183	Belongs to the thiolase family
O0R52_17005	COG1024	Enoyl-CoA hydratase
O0R52_17005	COG1250	3-hydroxyacyl-CoA dehydrogenase
O0R52_17015	COG0506	proline dehydrogenase activity
O0R52_17025	COG5577	PFAM Coat F domain
O0R52_17030	COG1846	Transcriptional regulator
O0R52_17035	COG0477	Major facilitator Superfamily
O0R52_17040	COG1942	4-Oxalocrotonate Tautomerase
O0R52_17045	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_17050	COG0583	DNA-binding transcription factor activity
O0R52_17060	COG1120	ATPase activity
O0R52_17075	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_17080	COG0783	Belongs to the Dps family
O0R52_17085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0R52_17090	COG0745	RESPONSE REGULATOR receiver
O0R52_17095	COG2205	protein histidine kinase activity
O0R52_17095	COG2770	Histidine kinase
O0R52_17105	COG1309	transcriptional regulator
O0R52_17110	COG0114	fumarate hydratase activity
O0R52_17120	COG0697	spore germination
O0R52_17125	COG0814	amino acid
O0R52_17135	COG2197	response regulator
O0R52_17140	COG4585	Histidine kinase
O0R52_17145	COG4758	membrane
O0R52_17150	COG3595	metallopeptidase activity
O0R52_17155	COG1842	Phage shock protein A
O0R52_17160	COG4758	membrane
O0R52_17165	COG2814	Major facilitator Superfamily
O0R52_17170	COG2096	Adenosyltransferase
O0R52_17175	COG1120	ATPase activity
O0R52_17180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R52_17185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R52_17190	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_17195	COG3386	PFAM SMP-30 Gluconolaconase
O0R52_17200	COG2205	protein histidine kinase activity
O0R52_17205	COG0745	RESPONSE REGULATOR receiver
O0R52_17215	COG1191	sigma factor activity
O0R52_17235	COG0577	efflux transmembrane transporter activity
O0R52_17240	COG1136	(ABC) transporter
O0R52_17245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O0R52_17250	COG1120	ATPase activity
O0R52_17255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R52_17260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R52_17265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R52_17270	COG0531	amino acid
O0R52_17280	COG1988	membrane-bound metal-dependent
O0R52_17285	COG1368	sulfuric ester hydrolase activity
O0R52_17290	COG1910	domain protein
O0R52_17295	COG0725	ABC transporter, periplasmic molybdate-binding protein
O0R52_17300	COG4149	molybdate abc transporter
O0R52_17305	COG0656	L-ascorbic acid biosynthetic process
O0R52_17315	COG0025	NhaP-type Na H and K H
O0R52_17320	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O0R52_17325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O0R52_17330	COG3973	AAA domain
O0R52_17340	COG2860	membrane
O0R52_17345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O0R52_17350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O0R52_17355	COG2217	Heavy metal translocating P-type atpase
O0R52_17360	COG2217	Heavy metal translocating P-type atpase
O0R52_17365	COG2608	mercury ion transmembrane transporter activity
O0R52_17370	COG1937	Protein conserved in bacteria
O0R52_17375	COG0673	inositol 2-dehydrogenase activity
O0R52_17380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O0R52_17385	COG1289	transmembrane transporter activity
O0R52_17390	COG1802	Transcriptional regulator
O0R52_17395	COG0697	spore germination
O0R52_17405	COG2076	Multidrug Resistance protein
O0R52_17410	COG1309	transcriptional regulator
O0R52_17415	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_17430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O0R52_17435	COG0557	exoribonuclease II activity
O0R52_17440	COG1647	Serine aminopeptidase, S33
O0R52_17445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O0R52_17450	COG0596	Alpha beta hydrolase
O0R52_17455	COG1476	TRANSCRIPTIONal
O0R52_17460	COG1396	sequence-specific DNA binding
O0R52_17465	COG1396	sequence-specific DNA binding
O0R52_17470	COG1733	regulation of RNA biosynthetic process
O0R52_17475	COG0840	transmembrane signaling receptor activity
O0R52_17480	COG1174	glycine betaine transport
O0R52_17485	COG1732	Glycine betaine
O0R52_17490	COG1174	glycine betaine transport
O0R52_17495	COG0517	IMP dehydrogenase activity
O0R52_17495	COG1125	glycine betaine transport
O0R52_17500	COG1510	regulation of RNA biosynthetic process
O0R52_17505	COG1174	glycine betaine transport
O0R52_17510	COG1732	Glycine betaine
O0R52_17515	COG1174	glycine betaine transport
O0R52_17520	COG0517	IMP dehydrogenase activity
O0R52_17520	COG1125	glycine betaine transport
O0R52_17525	COG1510	regulation of RNA biosynthetic process
O0R52_17535	COG3064	Membrane
O0R52_17540	COG4640	response to antibiotic
O0R52_17545	COG0456	acetyltransferase
O0R52_17560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O0R52_17580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O0R52_17585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O0R52_17595	COG2234	aminopeptidase activity
O0R52_17605	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O0R52_17610	COG0149	triose-phosphate isomerase activity
O0R52_17615	COG0126	phosphoglycerate kinase activity
O0R52_17625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O0R52_17630	COG2390	Transcriptional regulator
O0R52_17635	COG2814	Major facilitator Superfamily
O0R52_17640	COG1609	Transcriptional regulator
O0R52_17645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R52_17650	COG0583	DNA-binding transcription factor activity
O0R52_17655	COG0697	spore germination
O0R52_17660	COG1113	amino acid transport
O0R52_17665	COG3858	chitin binding
O0R52_17670	COG1556	Lactate utilization protein
O0R52_17675	COG1139	Iron-sulfur cluster binding protein
O0R52_17680	COG0247	lactate metabolic process
O0R52_17690	COG0596	Alpha beta hydrolase
O0R52_17695	COG2208	phosphoserine phosphatase activity
O0R52_17700	COG3867	Arabinogalactan endo-beta-1,4-galactanase
O0R52_17705	COG1874	Beta-galactosidase
O0R52_17710	COG3833	ABC-type maltose transport systems, permease component
O0R52_17715	COG1175	transmembrane transport
O0R52_17720	COG2182	Extracellular solute-binding protein
O0R52_17725	COG1609	Transcriptional regulator
O0R52_17730	COG2186	Transcriptional regulator
O0R52_17735	COG1620	l-lactate permease
O0R52_17740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
O0R52_17750	COG5039	Polysaccharide pyruvyl transferase
O0R52_17755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O0R52_17760	COG0110	maltose O-acetyltransferase activity
O0R52_17765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O0R52_17770	COG2244	polysaccharide biosynthetic process
O0R52_17775	COG1216	Glycosyl transferase, family 2
O0R52_17780	COG5039	Polysaccharide pyruvyl transferase
O0R52_17785	COG1216	Glycosyl transferase, family 2
O0R52_17795	COG0438	transferase activity, transferring glycosyl groups
O0R52_17800	COG1215	transferase activity, transferring glycosyl groups
O0R52_17805	COG0438	transferase activity, transferring glycosyl groups
O0R52_17810	COG1086	Polysaccharide biosynthesis protein
O0R52_17815	COG0489	protein tyrosine kinase activity
O0R52_17825	COG1396	sequence-specific DNA binding
O0R52_17830	COG2272	Belongs to the type-B carboxylesterase lipase family
O0R52_17840	COG3479	Phenolic acid decarboxylase
O0R52_17850	COG1794	racemase activity, acting on amino acids and derivatives
O0R52_17855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O0R52_17865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O0R52_17870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
O0R52_17875	COG0640	Transcriptional regulator
O0R52_17880	COG1621	beta-fructofuranosidase activity
O0R52_17885	COG1621	beta-fructofuranosidase activity
O0R52_17890	COG0531	amino acid
O0R52_17895	COG1309	transcriptional regulator
O0R52_17900	COG2076	Multidrug Resistance protein
O0R52_17905	COG2076	Multidrug Resistance protein
O0R52_17925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O0R52_17930	COG0366	Alpha amylase catalytic
O0R52_17935	COG1554	hydrolase, family 65, central catalytic
O0R52_17940	COG5521	maltodextrose utilization protein MalA
O0R52_17945	COG3833	ABC-type maltose transport systems, permease component
O0R52_17950	COG1175	transmembrane transport
O0R52_17955	COG2182	Extracellular solute-binding protein
O0R52_17965	COG1609	Transcriptional regulator
O0R52_17970	COG1611	Belongs to the LOG family
O0R52_17975	COG1694	Mazg nucleotide pyrophosphohydrolase
O0R52_17980	COG0659	secondary active sulfate transmembrane transporter activity
O0R52_17985	COG0288	reversible hydration of carbon dioxide
O0R52_17990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O0R52_17995	COG0577	efflux transmembrane transporter activity
O0R52_18000	COG1136	(ABC) transporter
O0R52_18005	COG5002	protein histidine kinase activity
O0R52_18010	COG0745	RESPONSE REGULATOR receiver
O0R52_18020	COG2162	N-hydroxyarylamine O-acetyltransferase activity
O0R52_18025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R52_18030	COG1481	regulation of sporulation
O0R52_18035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O0R52_18040	COG1660	Displays ATPase and GTPase activities
O0R52_18045	COG1051	belongs to the nudix hydrolase family
O0R52_18050	COG0492	ferredoxin-NADP+ reductase activity
O0R52_18055	COG0791	NLP P60 protein
O0R52_18055	COG3883	PFAM NLP P60 protein
O0R52_18060	COG0457	Tetratricopeptide repeat
O0R52_18065	COG1132	(ABC) transporter
O0R52_18095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O0R52_18095	COG0140	phosphoribosyl-ATP diphosphatase activity
O0R52_18100	COG0107	imidazoleglycerol-phosphate synthase activity
O0R52_18105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O0R52_18110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O0R52_18115	COG0131	Imidazoleglycerol-phosphate dehydratase
O0R52_18120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O0R52_18125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O0R52_18130	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
O0R52_18135	COG4990	cell redox homeostasis
O0R52_18140	COG5297	Belongs to the glycosyl hydrolase family 6
O0R52_18145	COG0110	maltose O-acetyltransferase activity
O0R52_18150	COG0546	phosphoglycolate phosphatase activity
O0R52_18155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
O0R52_18160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O0R52_18165	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
O0R52_18170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O0R52_18175	COG0363	glucosamine-6-phosphate deaminase activity
O0R52_18180	COG2188	Transcriptional regulator
O0R52_18185	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O0R52_18190	COG1846	Transcriptional regulator
O0R52_18195	COG2814	Major facilitator Superfamily
O0R52_18200	COG1950	PFAM Membrane protein of
O0R52_18205	COG1983	PspC domain protein
O0R52_18210	COG3595	metallopeptidase activity
O0R52_18225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O0R52_18235	COG4897	Protein conserved in bacteria
O0R52_18240	COG0574	Belongs to the PEP-utilizing enzyme family
O0R52_18240	COG3848	Pyruvate phosphate dikinase
O0R52_18245	COG1309	transcriptional regulator
O0R52_18250	COG2814	Major facilitator Superfamily
O0R52_18255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0R52_18265	COG3409	Peptidoglycan-binding domain 1 protein
O0R52_18265	COG0793	Belongs to the peptidase S41A family
O0R52_18270	COG2177	Part of the ABC transporter FtsEX involved in
O0R52_18275	COG2884	Cell division ATP-binding protein ftsE
O0R52_18280	COG2010	Cytochrome c
O0R52_18285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R52_18295	COG0653	protein targeting
O0R52_18300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O0R52_18315	COG1516	flagellar protein fliS
O0R52_18320	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
O0R52_18325	COG1334	flagellar protein FlaG
O0R52_18330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O0R52_18335	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O0R52_18340	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
O0R52_18350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O0R52_18355	COG1256	bacterial-type flagellum assembly
O0R52_18355	COG4786	Flagellar basal body rod
O0R52_18360	COG3418	PFAM FlgN family protein
O0R52_18365	COG2747	anti-sigma28 factor FlgM
O0R52_18375	COG1040	competence protein
O0R52_18385	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
O0R52_18390	COG1307	EDD domain protein, DegV family
O0R52_18395	COG2197	response regulator
O0R52_18400	COG4585	Histidine kinase
O0R52_18405	COG1739	Uncharacterized protein family UPF0029
O0R52_18410	COG1316	TRANSCRIPTIONal
O0R52_18415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O0R52_18420	COG0438	transferase activity, transferring glycosyl groups
O0R52_18425	COG1215	transferase activity, transferring glycosyl groups
O0R52_18430	COG3206	protein involved in exopolysaccharide biosynthesis
O0R52_18435	COG3307	-O-antigen
O0R52_18440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O0R52_18445	COG0438	transferase activity, transferring glycosyl groups
O0R52_18445	COG0297	glycogen (starch) synthase activity
O0R52_18450	COG2244	polysaccharide biosynthetic process
O0R52_18460	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R52_18460	COG2247	cell wall binding repeat
O0R52_18465	COG2385	sporulation resulting in formation of a cellular spore
O0R52_18465	COG2247	cell wall binding repeat
O0R52_18475	COG1316	TRANSCRIPTIONal
O0R52_18480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
O0R52_18485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O0R52_18500	COG0438	transferase activity, transferring glycosyl groups
O0R52_18505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O0R52_18530	COG1134	teichoic acid transport
O0R52_18535	COG1682	transport, permease protein
O0R52_18540	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O0R52_18545	COG0438	transferase activity, transferring glycosyl groups
O0R52_18550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
O0R52_18555	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
O0R52_18560	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O0R52_18570	COG4193	domain, Protein
O0R52_18575	COG1482	cell wall glycoprotein biosynthetic process
O0R52_18580	COG0697	spore germination
O0R52_18585	COG0814	amino acid
O0R52_18595	COG2814	Major facilitator Superfamily
O0R52_18600	COG1316	TRANSCRIPTIONal
O0R52_18605	COG0561	phosphatase activity
O0R52_18610	COG0791	NLP P60 protein
O0R52_18620	COG2843	Capsule synthesis protein
O0R52_18630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O0R52_18635	COG1609	Transcriptional regulator
O0R52_18640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O0R52_18645	COG1869	D-ribose catabolic process
O0R52_18650	COG1129	ABC transporter
O0R52_18655	COG1172	Belongs to the binding-protein-dependent transport system permease family
O0R52_18660	COG1879	ABC-type sugar transport system periplasmic component
O0R52_18665	COG3103	Sh3 type 3 domain protein
O0R52_18675	COG2249	NAD(P)H dehydrogenase (quinone) activity
O0R52_18680	COG3527	Alpha-acetolactate decarboxylase
O0R52_18685	COG0028	Belongs to the TPP enzyme family
O0R52_18690	COG0583	DNA-binding transcription factor activity
O0R52_18695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
O0R52_18710	COG5337	Spore coat protein CotH
O0R52_18720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O0R52_18725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R52_18740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O0R52_18750	COG0405	Gamma-glutamyltransferase
O0R52_18755	COG1522	sequence-specific DNA binding
O0R52_18760	COG2059	Chromate
O0R52_18765	COG2059	Chromate
O0R52_18775	COG0655	NAD(P)H dehydrogenase (quinone) activity
O0R52_18780	COG0583	DNA-binding transcription factor activity
O0R52_18830	COG5444	nuclease activity
O0R52_18850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O0R52_18855	COG4464	protein tyrosine phosphatase activity
O0R52_18860	COG0489	protein tyrosine kinase activity
O0R52_18865	COG3944	biosynthesis protein
O0R52_18875	COG4715	Zinc finger, swim domain protein
O0R52_18880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O0R52_18885	COG0561	phosphatase activity
O0R52_18890	COG1349	DNA-binding transcription factor activity
O0R52_18895	COG0629	single-stranded DNA binding
O0R52_18910	COG2602	Beta-lactamase
O0R52_18915	COG1970	mechanosensitive ion channel activity
O0R52_18920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O0R52_18925	COG0457	Tetratricopeptide repeat
O0R52_18930	COG4786	Flagellar basal body rod
O0R52_18935	COG4786	Flagellar basal body rod
O0R52_18940	COG1077	Cell shape determining protein MreB Mrl
O0R52_18945	COG1609	Transcriptional regulator
O0R52_18955	COG1846	Transcriptional regulator
O0R52_18960	COG2814	Major facilitator Superfamily
O0R52_18965	COG3420	alginic acid biosynthetic process
O0R52_18970	COG1953	Uracil, thiamine, allantoin
O0R52_18975	COG0477	Major facilitator Superfamily
O0R52_18980	COG1335	isochorismatase
O0R52_18990	COG0004	ammonium transporteR
O0R52_18995	COG0347	Belongs to the P(II) protein family
O0R52_19000	COG0671	phosphoesterase, PA-phosphatase related
O0R52_19010	COG0739	heme binding
O0R52_19015	COG1247	-acetyltransferase
O0R52_19025	COG1086	Polysaccharide biosynthesis protein
O0R52_19030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O0R52_19035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O0R52_19040	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
O0R52_19055	COG2089	acid synthase
O0R52_19065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O0R52_19075	COG2910	NAD(P)H-binding
O0R52_19080	COG1959	2 iron, 2 sulfur cluster binding
O0R52_19085	COG0804	urea catabolic process
O0R52_19090	COG0832	Belongs to the urease beta subunit family
O0R52_19095	COG0831	urea catabolic process
O0R52_19125	COG3237	CsbD-like
O0R52_19130	COG1994	Peptidase M50
O0R52_19135	COG0457	Tetratricopeptide repeat
O0R52_19140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O0R52_19145	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O0R52_19155	COG2304	oxidoreductase activity
O0R52_19160	COG2304	oxidoreductase activity
O0R52_19165	COG2385	sporulation resulting in formation of a cellular spore
O0R52_19170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O0R52_19180	COG4836	Membrane
O0R52_19190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O0R52_19195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O0R52_19200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O0R52_19210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O0R52_19215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O0R52_19225	COG0356	it plays a direct role in the translocation of protons across the membrane
O0R52_19235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O0R52_19240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O0R52_19245	COG4475	Protein of unknown function (DUF436)
O0R52_19250	COG0698	ribose 5-phosphate isomerase
O0R52_19255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O0R52_19260	COG1971	Probably functions as a manganese efflux pump
O0R52_19265	COG0009	L-threonylcarbamoyladenylate synthase
O0R52_19270	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O0R52_19290	COG2890	protein-(glutamine-N5) methyltransferase activity
O0R52_19295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O0R52_19300	COG0346	lactoylglutathione lyase activity
O0R52_19305	COG0789	Transcriptional regulator
O0R52_19310	COG0679	Auxin Efflux Carrier
O0R52_19315	COG0281	malic enzyme
O0R52_19320	COG1435	thymidine kinase activity
O0R52_19330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O0R52_19340	COG1494	fructose-1,6-bisphosphatase
O0R52_19345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O0R52_19350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O0R52_19355	COG0191	fructose-bisphosphate aldolase activity
O0R52_19360	COG2204	response regulator
O0R52_19365	COG4821	SIS domain
O0R52_19370	COG0504	CTP synthase activity
O0R52_19375	COG3343	RNA polymerase activity
O0R52_19380	COG1960	acyl-CoA dehydrogenase activity
O0R52_19385	COG2181	nitrate reductase activity
O0R52_19385	COG0247	lactate metabolic process
O0R52_19390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O0R52_19395	COG4294	response to UV
O0R52_19405	COG1476	TRANSCRIPTIONal
O0R52_19415	COG1132	(ABC) transporter
O0R52_19420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O0R52_19430	COG2181	nitrate reductase activity
O0R52_19435	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
O0R52_19440	COG1140	nitrate reductase beta subunit
O0R52_19445	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
O0R52_19450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O0R52_19460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O0R52_19465	COG2223	nitrite transmembrane transporter activity
O0R52_19470	COG0018	arginyl-trna synthetase
O0R52_19475	COG4506	Protein conserved in bacteria
O0R52_19490	COG0535	radical SAM domain protein
O0R52_19500	COG1131	(ABC) transporter
O0R52_19510	COG0612	Peptidase, M16
O0R52_19530	COG3391	amine dehydrogenase activity
O0R52_19535	COG0457	Tetratricopeptide repeat
O0R52_19545	COG0010	Belongs to the arginase family
O0R52_19550	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
O0R52_19555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O0R52_19570	COG1994	Peptidase M50
O0R52_19575	COG1942	4-Oxalocrotonate Tautomerase
O0R52_19580	COG1846	Transcriptional regulator
O0R52_19585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O0R52_19595	COG0477	Major facilitator Superfamily
O0R52_19600	COG1959	2 iron, 2 sulfur cluster binding
O0R52_19605	COG3465	dGTPase activity
O0R52_19610	COG1078	dGTPase activity
O0R52_19615	COG4844	belongs to the
O0R52_19625	COG0697	spore germination
O0R52_19630	COG0095	Lipoate-protein ligase
O0R52_19635	COG0583	DNA-binding transcription factor activity
O0R52_19640	COG0280	phosphate acetyltransferase
O0R52_19645	COG3253	May function as heme-dependent peroxidase
O0R52_19650	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_19655	COG0436	Aminotransferase
O0R52_19660	COG2814	Major facilitator Superfamily
O0R52_19665	COG0151	Belongs to the GarS family
O0R52_19670	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_19675	COG1917	Cupin 2, conserved barrel domain protein
O0R52_19680	COG0077	Prephenate dehydratase
O0R52_19685	COG2814	Major facilitator Superfamily
O0R52_19690	COG2814	Major facilitator Superfamily
O0R52_19695	COG0833	amino acid
O0R52_19700	COG4187	Peptidase family M20/M25/M40
O0R52_19705	COG1012	belongs to the aldehyde dehydrogenase family
O0R52_19710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O0R52_19720	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
O0R52_19725	COG1091	dTDP-4-dehydrorhamnose reductase activity
O0R52_19730	COG1088	dTDP-glucose 4,6-dehydratase activity
O0R52_19735	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
O0R52_19740	COG3980	spore coat polysaccharide biosynthesis protein
O0R52_19745	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
O0R52_19750	COG2089	acid synthase
O0R52_19755	COG0456	acetyltransferase
O0R52_19760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O0R52_19765	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O0R52_19770	COG0463	Glycosyl transferase, family 2
O0R52_19780	COG2363	Small membrane protein
O0R52_19785	COG2233	PERMEase
O0R52_19795	COG1012	belongs to the aldehyde dehydrogenase family
O0R52_19800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O0R52_19805	COG1216	Glycosyl transferase, family 2
O0R52_19820	COG1695	Transcriptional regulator
O0R52_19825	COG0351	phosphomethylpyrimidine kinase
O0R52_19835	COG1621	beta-fructofuranosidase activity
O0R52_19840	COG1263	PTS System
O0R52_19840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R52_19845	COG2116	formate transmembrane transporter activity
O0R52_19850	COG3711	transcriptional antiterminator
O0R52_19860	COG1404	Belongs to the peptidase S8 family
O0R52_19865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R52_19870	COG0778	Nitroreductase
O0R52_19875	COG0772	Belongs to the SEDS family
O0R52_19900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O0R52_19905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O0R52_19910	COG2261	transglycosylase associated protein
O0R52_19915	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
O0R52_19920	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O0R52_19925	COG2246	polysaccharide biosynthetic process
O0R52_19930	COG1309	transcriptional regulator
O0R52_19940	COG3162	membrane
O0R52_19945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O0R52_19950	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O0R52_19955	COG2837	iron assimilation
O0R52_19960	COG2822	iron ion transport
O0R52_19965	COG0672	)-iron permease
O0R52_19970	COG0352	thiamine-phosphate diphosphorylase activity
O0R52_19975	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
O0R52_19980	COG0583	DNA-binding transcription factor activity
O0R52_19985	COG1380	Effector of murein hydrolase LrgA
O0R52_19990	COG1346	cytolysis
O0R52_19995	COG2814	Major facilitator Superfamily
O0R52_20000	COG4895	conserved protein (DUF2196)
O0R52_20005	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O0R52_20010	COG0346	lactoylglutathione lyase activity
O0R52_20020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O0R52_20025	COG1404	Belongs to the peptidase S8 family
O0R52_20030	COG1263	PTS System
O0R52_20030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R52_20035	COG3711	transcriptional antiterminator
O0R52_20040	COG1442	glycosyl transferase family 8
O0R52_20045	COG5522	Integral membrane protein (intg_mem_TP0381)
O0R52_20050	COG1846	Transcriptional regulator
O0R52_20055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O0R52_20060	COG2234	aminopeptidase activity
O0R52_20075	COG2814	Major facilitator Superfamily
O0R52_20080	COG2357	RelA SpoT domain protein
O0R52_20085	COG1575	Belongs to the MenA family. Type 1 subfamily
O0R52_20095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R52_20100	COG1696	Membrane protein involved in D-alanine export
O0R52_20105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R52_20110	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
O0R52_20115	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
O0R52_20120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O0R52_20125	COG1486	melibiose metabolic process
O0R52_20130	COG1447	Phosphotransferase system cellobiose-specific component IIA
O0R52_20135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O0R52_20140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O0R52_20145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R52_20145	COG3711	transcriptional antiterminator
O0R52_20155	COG2094	Belongs to the DNA glycosylase MPG family
O0R52_20160	COG0753	catalase activity
O0R52_20165	COG2814	Major facilitator Superfamily
O0R52_20170	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O0R52_20175	COG1131	(ABC) transporter
O0R52_20195	COG1595	DNA-templated transcription, initiation
O0R52_20200	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O0R52_20205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O0R52_20210	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O0R52_20215	COG4988	ABC transporter
O0R52_20220	COG1294	oxidase, subunit
O0R52_20225	COG1271	oxidase subunit
O0R52_20230	COG3493	citrate carrier protein
O0R52_20235	COG0501	Belongs to the peptidase M48B family
O0R52_20245	COG0726	polysaccharide deacetylase
O0R52_20255	COG3842	ATPase activity
O0R52_20260	COG2508	Transcriptional regulator
O0R52_20265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R52_20275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O0R52_20280	COG1881	PFAM PEBP family protein
O0R52_20285	COG0583	DNA-binding transcription factor activity
O0R52_20300	COG2195	Cleaves the N-terminal amino acid of tripeptides
O0R52_20315	COG4894	glucomannan catabolic process
O0R52_20320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O0R52_20325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O0R52_20330	COG3829	transcription factor binding
O0R52_20330	COG3290	protein histidine kinase activity
O0R52_20335	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_20340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O0R52_20345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O0R52_20350	COG2610	gluconate transmembrane transporter activity
O0R52_20355	COG0500	methyltransferase
O0R52_20360	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_20365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O0R52_20380	COG0693	protein deglycase activity
O0R52_20380	COG0753	catalase activity
O0R52_20385	COG2851	Citrate transporter
O0R52_20390	COG2323	membrane
O0R52_20400	COG2723	6-phospho-beta-galactosidase activity
O0R52_20405	COG1263	PTS System
O0R52_20405	COG2190	(PTS) system
O0R52_20405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R52_20410	COG3711	transcriptional antiterminator
O0R52_20420	COG2270	Major facilitator Superfamily
O0R52_20425	COG0513	Belongs to the DEAD box helicase family
O0R52_20430	COG2755	lipolytic protein G-D-S-L family
O0R52_20430	COG3401	FG-GAP repeat protein
O0R52_20495	COG0697	spore germination
O0R52_20500	COG0589	response to stress
O0R52_20505	COG2723	6-phospho-beta-galactosidase activity
O0R52_20510	COG1263	PTS System
O0R52_20510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R52_20510	COG2190	(PTS) system
O0R52_20555	COG5444	nuclease activity
O0R52_20590	COG3507	Belongs to the glycosyl hydrolase 43 family
O0R52_20605	COG2986	histidine ammonia-lyase
O0R52_20610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O0R52_20615	COG1228	amidohydrolase
O0R52_20620	COG0010	Belongs to the arginase family
O0R52_20625	COG0833	amino acid
O0R52_20630	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
O0R52_20635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O0R52_20640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O0R52_20645	COG2390	Transcriptional regulator
O0R52_20675	COG1131	(ABC) transporter
O0R52_20695	COG3192	ethanolamine utilization protein
O0R52_20700	COG2079	MmgE PrpD family protein
O0R52_20705	COG1473	amidohydrolase
O0R52_20710	COG1126	abc transporter atp-binding protein
O0R52_20715	COG0765	amino acid transport
O0R52_20720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R52_20725	COG0456	acetyltransferase
O0R52_20730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R52_20740	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
O0R52_20745	COG0561	phosphatase activity
O0R52_20775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R52_20780	COG5294	Protein conserved in bacteria
O0R52_20785	COG0577	efflux transmembrane transporter activity
O0R52_20790	COG1136	(ABC) transporter
O0R52_20795	COG2205	protein histidine kinase activity
O0R52_20800	COG0745	RESPONSE REGULATOR receiver
O0R52_20805	COG0191	fructose-bisphosphate aldolase activity
O0R52_20815	COG1082	Xylose isomerase domain protein TIM barrel
O0R52_20820	COG0673	inositol 2-dehydrogenase activity
O0R52_20825	COG2814	Major facilitator Superfamily
O0R52_20830	COG1082	Xylose isomerase domain protein TIM barrel
O0R52_20835	COG3962	Belongs to the TPP enzyme family
O0R52_20840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O0R52_20850	COG1012	belongs to the aldehyde dehydrogenase family
O0R52_20855	COG1349	DNA-binding transcription factor activity
O0R52_20860	COG0667	Aldo Keto reductase
O0R52_20885	COG2814	Major facilitator Superfamily
O0R52_20890	COG0326	Molecular chaperone. Has ATPase activity
O0R52_20900	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_20905	COG1309	transcriptional regulator
O0R52_20910	COG1012	belongs to the aldehyde dehydrogenase family
O0R52_20915	COG1714	RDD family
O0R52_20920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O0R52_20930	COG1714	RDD family
O0R52_20935	COG2311	Membrane
O0R52_20945	COG1309	transcriptional regulator
O0R52_20950	COG1028	Short-chain dehydrogenase reductase Sdr
O0R52_20980	COG5039	Polysaccharide pyruvyl transferase
O0R52_20985	COG1929	Belongs to the glycerate kinase type-1 family
O0R52_20990	COG1802	Transcriptional regulator
O0R52_20995	COG1070	Carbohydrate kinase
O0R52_21000	COG2610	gluconate transmembrane transporter activity
O0R52_21005	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O0R52_21010	COG0450	alkyl hydroperoxide reductase
O0R52_21015	COG3634	alkyl hydroperoxide reductase activity
O0R52_21030	COG1113	amino acid transport
O0R52_21035	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
O0R52_21045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O0R52_21060	COG1063	alcohol dehydrogenase
O0R52_21080	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
O0R52_21090	COG0457	Tetratricopeptide repeat
O0R52_21100	COG0010	Belongs to the arginase family
O0R52_21105	COG0833	amino acid
O0R52_21110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O0R52_21115	COG3829	transcription factor binding
O0R52_21120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0R52_21125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O0R52_21130	COG4853	Protein conserved in bacteria
O0R52_21135	COG4863	YycH protein
O0R52_21140	COG5002	protein histidine kinase activity
O0R52_21145	COG0745	RESPONSE REGULATOR receiver
O0R52_21175	COG0346	lactoylglutathione lyase activity
O0R52_21180	COG0305	Participates in initiation and elongation during chromosome replication
O0R52_21195	COG3093	addiction module antidote protein HigA
O0R52_21200	COG2807	transmembrane transport
O0R52_21205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O0R52_21210	COG0359	binds to the 23S rRNA
O0R52_21215	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
O0R52_21220	COG4241	membrane
O0R52_21230	COG5577	PFAM Coat F domain
O0R52_21235	COG1733	regulation of RNA biosynthetic process
O0R52_21240	COG1227	inorganic diphosphatase activity
O0R52_21250	COG2271	Major facilitator Superfamily
O0R52_21255	COG4978	Transcriptional regulator
O0R52_21255	COG0789	Transcriptional regulator
O0R52_21270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R52_21280	COG0640	Transcriptional regulator
O0R52_21285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O0R52_21290	COG2409	Drug exporters of the RND superfamily
O0R52_21295	COG2197	response regulator
O0R52_21300	COG4585	Histidine kinase
O0R52_21315	COG0789	Transcriptional regulator
O0R52_21315	COG4978	Transcriptional regulator
O0R52_21320	COG1811	Na channel or pump
O0R52_21335	COG0789	Transcriptional regulator
O0R52_21340	COG0697	spore germination
O0R52_21345	COG1331	Highly conserved protein containing a thioredoxin domain
O0R52_21350	COG1266	CAAX protease self-immunity
O0R52_21355	COG0477	Major facilitator Superfamily
O0R52_21355	COG2814	Major facilitator Superfamily
O0R52_21360	COG0110	maltose O-acetyltransferase activity
O0R52_21365	COG0346	lactoylglutathione lyase activity
O0R52_21370	COG1609	Transcriptional regulator
O0R52_21375	COG0708	Exodeoxyribonuclease III
O0R52_21385	COG0629	single-stranded DNA binding
O0R52_21390	COG0360	Binds together with S18 to 16S ribosomal RNA
O0R52_21395	COG0012	GTP binding
O0R52_21400	COG0243	molybdopterin cofactor binding
O0R52_21405	COG4481	Protein conserved in bacteria
O0R52_21410	COG3949	Membrane
O0R52_21420	COG1475	DNA binding
O0R52_21425	COG1192	Involved in chromosome partitioning
O0R52_21435	COG1475	DNA binding
O0R52_21440	COG0357	Ribosomal RNA small subunit methyltransferase G
O0R52_21445	COG0445	tRNA wobble uridine modification
O0R52_21450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O0R52_21455	COG1847	R3H domain protein
O0R52_21460	COG0706	membrane insertase activity
O0R52_21465	COG0594	ribonuclease P activity
O0R52_21475	COG0791	NLP P60 protein
O0R52_21475	COG0741	lytic transglycosylase activity
O0R52_21605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O0R52_21610	COG2304	oxidoreductase activity
O0R52_21655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O0R52_21665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O0R52_21670	COG4112	unkown
O0R52_21685	COG2131	deaminase
O0R52_21755	COG0194	GDP metabolic process
O0R52_21800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O0R52_21840	COG0457	Tetratricopeptide repeat
O0R52_21850	COG5444	nuclease activity
O0R52_21865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O0R52_21900	COG0592	DNA-directed DNA polymerase activity
O0R52_21945	COG0358	DNA primase activity
O0R52_21960	COG0210	DNA helicase
O0R52_22055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O0R52_22170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O0R52_22195	COG3584	3D domain protein
O0R52_22195	COG1388	LysM domain
O0R52_22205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD