locus-tag class description FLQ13_00035 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FLQ13_00055 ENOG4105C3M thioredoxin reductase FLQ13_00060 ENOG4105K63 Thioredoxin FLQ13_00070 ENOG4105XXY Thioredoxin FLQ13_00080 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FLQ13_00090 ENOG4108WUH Transcriptional regulator, TetR family FLQ13_00110 ENOG4105FTQ Dna gyrase FLQ13_00130 ENOG4107RSM transcriptional regulator FLQ13_00145 ENOG4105KVH Transcriptional regulator FLQ13_00170 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FLQ13_00180 ENOG41067XF inhibitor FLQ13_00210 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FLQ13_00230 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FLQ13_00235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLQ13_00240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLQ13_00250 ENOG4108JQ7 (ABC) transporter FLQ13_00255 ENOG4108MEK Metal-binding protein YodA FLQ13_00265 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein FLQ13_00270 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein FLQ13_00285 ENOG4105KRI phosphocarrier protein (HPr FLQ13_00295 ENOG4105VUF Transcriptional regulator FLQ13_00305 ENOG4105DQ4 alcohol dehydrogenase FLQ13_00310 ENOG4108Z0Z intracellular protease Pfpi family FLQ13_00315 ENOG4108HKT sucrose-6-phosphate hydrolase FLQ13_00320 ENOG4105F3R pts system mannose fructose sorbose family iid FLQ13_00330 ENOG4108IQ3 PTS system FLQ13_00335 ENOG4105YHU PTS system FLQ13_00350 ENOG4105N14 lysine exporter protein LysE YggA FLQ13_00355 ENOG4108NGU Transcriptional regulator FLQ13_00360 ENOG4105JVQ RNA Polymerase FLQ13_00365 ENOG4108P49 AntiSigma factor FLQ13_00370 ENOG4105EXC Acyl-transferase FLQ13_00375 ENOG4105WDR FLQ13_00380 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FLQ13_00385 ENOG41082JN Transcriptional regulator FLQ13_00405 ENOG4105TMB Formate nitrite transporter FLQ13_00410 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FLQ13_00415 ENOG4108JB9 formate dehydrogenase FLQ13_00435 ENOG4105C28 cystathionine FLQ13_00450 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FLQ13_00465 ENOG4107XRG penicillin-binding protein FLQ13_00470 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FLQ13_00475 ENOG4105DBI uridine monophosphokinase FLQ13_00480 ENOG4105CFP Peptidase U32 FLQ13_00490 ENOG4108VQJ O-methyltransferase FLQ13_00495 ENOG4105HHA aminodeoxychorismate lyase FLQ13_00500 ENOG4105VPH UPF0473 protein FLQ13_00505 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FLQ13_00510 ENOG4105VBH UPF0297 protein FLQ13_00515 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FLQ13_00520 ENOG4105C02 permease FLQ13_00525 ENOG4105CDA abc transporter atp-binding protein FLQ13_00530 ENOG4105CT1 (ABC) transporter FLQ13_00535 ENOG4105EAD ABC transporter FLQ13_00540 ENOG4105DRP amino acid AbC transporter FLQ13_00550 ENOG41060CR FLQ13_00560 ENOG4105C7H Helicase, RecD TraA family FLQ13_00570 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FLQ13_00575 ENOG4105C3J Cysteine desulfurase FLQ13_00585 ENOG4105D1H recombination factor protein RarA FLQ13_00590 ENOG4105CUZ uba thif-type nad fad binding protein FLQ13_00600 ENOG4105C9M aspartyl-trna synthetase FLQ13_00605 ENOG4105CUT histidyl-tRNA synthetase FLQ13_00615 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FLQ13_00620 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FLQ13_00625 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FLQ13_00630 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FLQ13_00640 ENOG41067VP Protein of unknown function (DUF1049) FLQ13_00645 ENOG4105NCW Trka-c domain protein FLQ13_00650 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FLQ13_00665 ENOG4108QG2 Membrane FLQ13_00670 ENOG4105NAP FLQ13_00675 ENOG4105VIE preprotein translocase, subunit YajC FLQ13_00685 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FLQ13_00690 ENOG41061AI Protein of unknown function (DUF2905) FLQ13_00695 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FLQ13_00700 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FLQ13_00710 ENOG4105IE8 Alpha-ketoglutarate permease FLQ13_00735 ENOG4105BZG amino acid carrier protein FLQ13_00740 ENOG4105CDY transcriptional regulatory protein FLQ13_00755 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FLQ13_00760 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FLQ13_00765 ENOG4108IYU L-aspartate oxidase FLQ13_00780 ENOG4105CQC Prephenate dehydratase FLQ13_00785 ENOG41090I5 UPF0735 ACT domain-containing protein FLQ13_00790 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FLQ13_00805 ENOG4105K46 50S ribosomal protein l27 FLQ13_00810 ENOG4105X36 (ribosomal) protein FLQ13_00815 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FLQ13_00830 ENOG4107QMS site-determining protein FLQ13_00835 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FLQ13_00840 ENOG4105YHC Rod shape-determining protein MreD FLQ13_00845 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FLQ13_00850 ENOG4105DFF Rod shape-determining protein mreb FLQ13_00860 ENOG4108Z03 MAF-like protein FLQ13_00870 ENOG4106A3R peptidase FLQ13_00875 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FLQ13_00880 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FLQ13_00890 ENOG4106AR7 Spore coat protein FLQ13_00895 ENOG41068KH stage VI sporulation protein D FLQ13_00900 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FLQ13_00905 ENOG4105D52 delta-aminolevulinic acid dehydratase FLQ13_00915 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FLQ13_00925 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FLQ13_00935 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FLQ13_00945 ENOG4108IUQ atp-dependent protease FLQ13_00950 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FLQ13_00955 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FLQ13_00965 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FLQ13_00970 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FLQ13_00975 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FLQ13_00980 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FLQ13_00985 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FLQ13_00990 ENOG4108ZP8 Acetolactate synthase small subunit FLQ13_00995 ENOG4105C7K acetolactate synthase FLQ13_01005 ENOG4105I4A GCN5-related N-acetyltransferase FLQ13_01010 ENOG4107KM7 Heat induced stress protein YflT FLQ13_01020 ENOG4105M59 Phosphodiesterase, mj0936 family FLQ13_01025 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FLQ13_01035 ENOG4108XJQ germination protein FLQ13_01040 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FLQ13_01045 ENOG41067TZ transcriptional regulator, MarR family FLQ13_01050 ENOG4105PFC Transcriptional regulator FLQ13_01060 ENOG4105E33 succinate dehydrogenase FLQ13_01070 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FLQ13_01080 ENOG4105CFH Aspartokinase FLQ13_01090 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FLQ13_01095 ENOG4105K63 Thioredoxin FLQ13_01100 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FLQ13_01105 ENOG4105C10 Electron transfer flavoprotein FLQ13_01110 ENOG4105BZJ Electron transfer flavoprotein FLQ13_01115 ENOG41060WC Enoyl-CoA hydratase FLQ13_01120 ENOG4107Z3H Transcriptional regulator, TetR family FLQ13_01125 ENOG4105CEY Amp-dependent synthetase and ligase FLQ13_01135 ENOG4105C98 muts2 protein FLQ13_01140 ENOG4105DCG PHP domain protein FLQ13_01155 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FLQ13_01160 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FLQ13_01175 ENOG4108RWN rrna methyltransferase FLQ13_01180 ENOG41067MF small acid-soluble spore protein FLQ13_01190 ENOG4105CQB FAD linked oxidase domain protein FLQ13_01195 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FLQ13_01220 ENOG4105K7K Transcriptional regulator FLQ13_01225 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FLQ13_01230 ENOG4105DRS transport system, permease FLQ13_01245 ENOG4108MDK Dehydrogenase FLQ13_01255 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FLQ13_01260 ENOG4105EF1 ribulokinase FLQ13_01270 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase FLQ13_01275 ENOG4105CN9 Peptidase m42 family protein FLQ13_01285 ENOG410696E Membrane FLQ13_01290 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FLQ13_01295 ENOG4105VJV 50s ribosomal protein L35 FLQ13_01300 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FLQ13_01310 ENOG41067MG lrgb family FLQ13_01325 ENOG4108HRK Histidine kinase FLQ13_01330 ENOG4105U0R haloacid dehalogenase-like hydrolase FLQ13_01335 ENOG4105C22 threonyL-tRNA synthetase FLQ13_01340 ENOG4108TDW sporulation protein YtxC FLQ13_01360 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FLQ13_01365 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FLQ13_01370 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FLQ13_01375 ENOG4105KVH Transcriptional regulator FLQ13_01380 ENOG4105F27 Major Facilitator FLQ13_01385 ENOG4105CV8 reductase FLQ13_01390 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FLQ13_01400 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FLQ13_01405 ENOG4105C2M dna polymerase I FLQ13_01410 ENOG4105BZU Histidine kinase FLQ13_01415 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FLQ13_01420 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FLQ13_01425 ENOG4108HMX isocitrate dehydrogenase (NADP) FLQ13_01430 ENOG4105BZN citrate synthase FLQ13_01440 ENOG4108REF Sporulation integral membrane protein ytvi FLQ13_01445 ENOG4105FS0 cytoplasmic membrane protein FLQ13_01450 ENOG4105CA9 Pyruvate kinase FLQ13_01455 ENOG4105CTQ phosphohexokinase FLQ13_01465 ENOG4108IEY Carboxyl transferase domain FLQ13_01470 ENOG4105C6K Malic enzyme FLQ13_01475 ENOG4105C0B DNA polymerase III (alpha subunit) FLQ13_01480 ENOG4105VV2 FLQ13_01490 ENOG4106EVM FLQ13_01495 ENOG4105SFS phosphoesterase RecJ domain protein FLQ13_01510 ENOG410635A Membrane FLQ13_01515 ENOG4105CH2 amidohydrolase FLQ13_01540 ENOG4105CDA abc transporter atp-binding protein FLQ13_01565 ENOG4108XSB acetyltransferase, (GNAT) family FLQ13_01570 ENOG4108KSA LysR family transcriptional regulator FLQ13_01575 ENOG4105E8R UPF0173 metal-dependent hydrolase FLQ13_01590 ENOG4105CH7 arginosuccinase FLQ13_01595 ENOG4105CDH Citrulline--aspartate ligase FLQ13_01600 ENOG4105EPU Molybdenum cofactor synthesis domain protein FLQ13_01605 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FLQ13_01615 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FLQ13_01620 ENOG4105KBJ sporulation protein ytfj FLQ13_01630 ENOG4105VK3 rdd domain containing protein FLQ13_01635 ENOG4105D07 Signal peptide peptidase, SppA FLQ13_01640 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FLQ13_01645 ENOG4105EFZ amidohydrolase FLQ13_01650 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FLQ13_01685 ENOG4105U5Y Transcriptional regulator FLQ13_01705 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FLQ13_01710 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FLQ13_01720 ENOG4105F1V Acetoin utilization protein FLQ13_01725 ENOG4105W87 Cbs domain FLQ13_01735 ENOG4105ER2 Ompa motb domain protein FLQ13_01740 ENOG4107R0U MotA TolQ exbB proton channel FLQ13_01745 ENOG4105ETE Transcriptional regulator (LacI family FLQ13_01750 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FLQ13_01770 ENOG4105DFU Cell wall formation (By similarity) FLQ13_01780 ENOG4108VDD TRNA binding domain protein FLQ13_01800 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ FLQ13_01815 ENOG4105C6K Malic enzyme FLQ13_01825 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FLQ13_01835 ENOG4108V15 phosphotransferase enzyme family FLQ13_01840 ENOG4108IUM Glycogen debranching enzyme FLQ13_01855 ENOG4107F58 2'-5' rna ligase FLQ13_01860 ENOG4105C6T cysteine synthase FLQ13_01865 ENOG4107QSE Dipeptidase FLQ13_01870 ENOG4105C7N Xanthine uracil vitamin C permease FLQ13_01885 ENOG4105YW5 deoR family transcriptional regulator FLQ13_01915 ENOG4105MU9 integral membrane protein FLQ13_01940 ENOG41075H3 AraC family transcriptional regulator FLQ13_01950 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FLQ13_01960 ENOG4106A3M Cytochrome p-450 FLQ13_01965 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FLQ13_01975 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FLQ13_01980 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FLQ13_02005 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FLQ13_02010 ENOG4105I1K ABC transporter FLQ13_02025 ENOG4105C8T Leucyl-tRNA synthetase FLQ13_02035 ENOG4105BZU Histidine kinase FLQ13_02040 ENOG410605W Major Facilitator FLQ13_02045 ENOG4106UBQ FLQ13_02055 ENOG4105C19 ABC transporter FLQ13_02060 ENOG4105EWM Histidine kinase FLQ13_02070 ENOG4107R34 abc transporter permease protein FLQ13_02075 ENOG4105C19 ABC transporter FLQ13_02090 ENOG4105DVE abc transporter atp-binding protein FLQ13_02105 ENOG4105N5T Radical SAM Protein FLQ13_02120 ENOG4105E8V Alpha Beta Hydrolase Fold protein FLQ13_02125 ENOG4108Z0R Transferase FLQ13_02130 ENOG4105C85 amino acid FLQ13_02135 ENOG4105CAQ asparagine synthetase FLQ13_02140 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FLQ13_02145 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FLQ13_02160 ENOG4105D2X ABC transporter substrate-binding protein FLQ13_02170 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FLQ13_02185 ENOG4108RMU ferritin dps family protein FLQ13_02200 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FLQ13_02205 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FLQ13_02210 ENOG4108V2W Carbonate dehydratase FLQ13_02235 ENOG4105CC5 ABC transporter FLQ13_02240 ENOG4105CC5 ABC transporter FLQ13_02245 ENOG4105DIK (ABC) transporter FLQ13_02250 ENOG4105DSE periplasmic solute binding protein FLQ13_02255 ENOG4105DTQ mandelate racemase muconate lactonizing FLQ13_02260 ENOG4105CEY Amp-dependent synthetase and ligase FLQ13_02265 ENOG4108IPT Naphthoate synthase FLQ13_02270 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FLQ13_02275 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FLQ13_02280 ENOG4105E4F Isochorismate synthase FLQ13_02300 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FLQ13_02310 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FLQ13_02445 ENOG4105VRR gCN5-related N-acetyltransferase FLQ13_02450 ENOG4105DZ6 Band 7 protein FLQ13_02460 ENOG4106DF1 FLQ13_02465 ENOG4108VNY MOSC domain protein FLQ13_02470 ENOG4108JB8 alcohol dehydrogenase FLQ13_02475 ENOG4105C26 Dehydrogenase FLQ13_02480 ENOG4105TRT Transcriptional regulator FLQ13_02500 ENOG4107I77 yiaA/B two helix domain FLQ13_02505 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FLQ13_02535 ENOG4105EE0 oxidoreductase FLQ13_02540 ENOG4105DKG l-rhamnose isomerase FLQ13_02550 ENOG4105DET Rhamnulokinase FLQ13_02555 ENOG4105E98 transcriptional regulator DeoR family FLQ13_02565 ENOG4105C8Q Methyl-accepting chemotaxis FLQ13_02570 ENOG4105C8Q Methyl-accepting chemotaxis FLQ13_02575 ENOG4105C8Q Methyl-accepting chemotaxis FLQ13_02580 ENOG4105C8Q Methyl-accepting chemotaxis FLQ13_02595 ENOG4105EA8 2-Nitropropane dioxygenase FLQ13_02600 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FLQ13_02615 ENOG4105C37 (CBS) domain FLQ13_02630 ENOG4107PBV potassium channel FLQ13_02635 ENOG4107PBV potassium channel FLQ13_02650 ENOG4107QYV phosphohexose isomerase FLQ13_02665 ENOG4105WG9 Conserved Protein FLQ13_02680 ENOG4108ZB6 transcriptional regulator AsnC family FLQ13_02685 ENOG4108MUZ hydrolase FLQ13_02695 ENOG4105C87 Aminotransferase class I and II FLQ13_02700 ENOG4108HGU Histidine kinase FLQ13_02705 ENOG4105Y38 Kinase-associated protein B FLQ13_02725 ENOG4105BZ4 penicillin-binding protein FLQ13_02730 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FLQ13_02745 ENOG4108MRH transcriptional regulatory protein FLQ13_02750 ENOG4105DIH basic membrane FLQ13_02755 ENOG4108JQ9 ABC transporter FLQ13_02760 ENOG4105UIB (ABC) transporter FLQ13_02780 ENOG4105D65 subunit l FLQ13_02785 ENOG4105HC0 Na H antiporter FLQ13_02790 ENOG4108ZE9 Monovalent cation H antiporter subunit C FLQ13_02795 ENOG4108JPZ Monovalent cation H antiporter subunit D FLQ13_02800 ENOG4105SC1 monovalent cation H antiporter subunit E FLQ13_02810 ENOG4105KJM monovalent cation h antiporter subunit g FLQ13_02815 ENOG4105KA0 thioesterase Superfamily protein FLQ13_02825 ENOG4105BZU Histidine kinase FLQ13_02850 ENOG4105D58 Diguanylate phosphodiesterase FLQ13_02855 ENOG4105DAP Nicotinate phosphoribosyltransferase FLQ13_02880 ENOG4105C02 permease FLQ13_02900 ENOG410904N short-chain dehydrogenase reductase FLQ13_02935 ENOG4108K8K Transcriptional regulator FLQ13_02940 ENOG4105DCF alanine dehydrogenase FLQ13_02950 ENOG4105WQT MbtH domain protein FLQ13_02955 ENOG4105CEY Amp-dependent synthetase and ligase FLQ13_02960 ENOG4105WQI isochorismatase FLQ13_02965 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FLQ13_02970 ENOG4105E4F Isochorismate synthase FLQ13_02975 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FLQ13_02980 ENOG4105NIV Esterase FLQ13_03000 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FLQ13_03010 ENOG41069ER domain protein FLQ13_03025 ENOG4105CEP NADH dehydrogenase FLQ13_03030 ENOG4105CAY ferredoxin--nadp reductase FLQ13_03045 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FLQ13_03060 ENOG4105ZKE UPF0349 protein FLQ13_03075 ENOG41083MR nifu domain-containing protein FLQ13_03080 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FLQ13_03085 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FLQ13_03090 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FLQ13_03105 ENOG4108W5N phosphatidylglycerophosphatase a FLQ13_03110 ENOG4105D4U had-superfamily hydrolase, subfamily iia FLQ13_03125 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FLQ13_03130 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FLQ13_03135 ENOG4105FAA peptidase M23 FLQ13_03140 ENOG4108YTE sporulation protein YunB FLQ13_03145 ENOG4105KZD Domain of unknown function (DUF1805) FLQ13_03150 ENOG4107R8B 5'-nucleotidase FLQ13_03160 ENOG4105I3N Conserved Protein FLQ13_03175 ENOG4105G9B Transcriptional regulator FLQ13_03190 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) FLQ13_03205 ENOG4107YV9 domain protein FLQ13_03225 ENOG4105XRQ Xanthine dehydrogenase accessory factor FLQ13_03235 ENOG4105C5R Aminotransferase FLQ13_03245 ENOG4108K8S endonuclease I FLQ13_03250 ENOG4108IJ9 (ABC) transporter FLQ13_03255 ENOG4105FDP GntR family transcriptional regulator FLQ13_03260 ENOG4108KPW sugar kinase FLQ13_03265 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FLQ13_03270 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FLQ13_03275 ENOG4105XN3 extracellular solute-binding protein family 1 FLQ13_03280 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine FLQ13_03285 ENOG4105PKS Excinuclease abc c subunit domain protein FLQ13_03310 ENOG4105DIW FeS assembly protein SUFB FLQ13_03315 ENOG4108UNV SUF system FeS assembly protein, NifU family FLQ13_03320 ENOG4105C9B Cysteine desulfurase FLQ13_03325 ENOG4105JRK feS assembly protein SufD FLQ13_03330 ENOG4105C3K feS assembly ATPase SufC FLQ13_03345 ENOG4105D01 (LipO)protein FLQ13_03350 ENOG4108UMI ABC transporter, permease FLQ13_03355 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FLQ13_03380 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FLQ13_03385 ENOG41080E8 Transcriptional regulator, Spx MgsR family FLQ13_03390 ENOG4105C1G acyl-Coa dehydrogenase FLQ13_03395 ENOG4105CHU acetyl-coa acetyltransferase FLQ13_03425 ENOG41067TZ transcriptional regulator, MarR family FLQ13_03430 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLQ13_03435 ENOG4105MDS 4-oxalocrotonate tautomerase FLQ13_03445 ENOG4105EGI Transcriptional regulator FLQ13_03455 ENOG4105E0A ABC, transporter FLQ13_03470 ENOG4105E1F short-chain dehydrogenase reductase FLQ13_03475 ENOG4105HUF DNA protection during starvation protein FLQ13_03480 ENOG4105C0H protease FLQ13_03490 ENOG4105F3H Histidine kinase FLQ13_03500 ENOG41067SE Tetr family transcriptional regulator FLQ13_03505 ENOG4105C9Q fumarate hydratase class II FLQ13_03530 ENOG4105WH1 Two component transcriptional regulator luxr family FLQ13_03535 ENOG4105ENE Histidine kinase FLQ13_03550 ENOG41087YS Phage shock protein A FLQ13_03570 ENOG4108WBT adenosyltransferase FLQ13_03580 ENOG4105EHG Permease protein FLQ13_03585 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FLQ13_03590 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FLQ13_03595 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FLQ13_03605 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FLQ13_03615 ENOG4106DF4 Sigma-70, region 4 FLQ13_03625 ENOG4105F0F Oxalate decarboxylase FLQ13_03635 ENOG4107RBB ABC transporter, permease FLQ13_03640 ENOG4105C19 ABC transporter FLQ13_03645 ENOG4108WMK Efflux transporter RND family MFP subunit FLQ13_03650 ENOG4105E0A ABC, transporter FLQ13_03655 ENOG4105EHG Permease protein FLQ13_03660 ENOG4105DQ5 transport system permease protein FLQ13_03675 ENOG4105D5Q Arginine ornithine antiporter FLQ13_03685 ENOG4107K5X Membrane-bound metal-dependent hydrolase FLQ13_03690 ENOG4107QZ2 Sulfatase FLQ13_03695 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FLQ13_03700 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FLQ13_03705 ENOG4105E0C molybdate abc transporter FLQ13_03720 ENOG4105EEQ Na H antiporter FLQ13_03725 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FLQ13_03745 ENOG4105EN6 Membrane FLQ13_03760 ENOG4107ZQN disulfide bond FLQ13_03765 ENOG4105C59 p-type ATPase FLQ13_03770 ENOG4105C59 p-type ATPase FLQ13_03775 ENOG410681U heavy metal transport detoxification protein FLQ13_03780 ENOG4105VPX protein, conserved in bacteria FLQ13_03785 ENOG4105D9R oxidoreductase FLQ13_03790 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FLQ13_03795 ENOG4105ME7 Membrane FLQ13_03800 ENOG4105DRR Transcriptional regulator, GntR family FLQ13_03805 ENOG4108UZ3 Transporter FLQ13_03810 ENOG4105RXJ FLQ13_03815 ENOG4105KPY Small multidrug resistance protein FLQ13_03820 ENOG4105KBX Transcriptional regulator, TetR family FLQ13_03825 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FLQ13_03835 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FLQ13_03840 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FLQ13_03850 ENOG4105XZU Preprotein translocase, subunit SecG FLQ13_03875 ENOG4105KVH Transcriptional regulator FLQ13_03880 ENOG4105C8Q Methyl-accepting chemotaxis FLQ13_03885 ENOG4105R40 Glycine betaine carnitine choline FLQ13_03890 ENOG4108HQR Glycine betaine FLQ13_03895 ENOG4105E90 ABC transporter FLQ13_03900 ENOG4108IJ8 ABC transporter FLQ13_03905 ENOG4107HG4 Transcriptional regulator FLQ13_03910 ENOG4105R40 Glycine betaine carnitine choline FLQ13_03915 ENOG4108HQR Glycine betaine FLQ13_03920 ENOG4105E90 ABC transporter FLQ13_03925 ENOG4108IJ8 ABC transporter FLQ13_03930 ENOG4107HG4 Transcriptional regulator FLQ13_03935 ENOG4108QCI YvbH-like oligomerisation region FLQ13_03945 ENOG4105T65 Membrane-associated protein FLQ13_03950 ENOG4108W0I acetyltransferase FLQ13_03965 ENOG4105FJR Lmbe family FLQ13_03985 ENOG4108IAJ Nad-dependent epimerase dehydratase FLQ13_03990 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FLQ13_03995 ENOG4107QQG Dehydrogenase FLQ13_04000 ENOG4105IIU Aminopeptidase FLQ13_04005 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FLQ13_04010 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FLQ13_04015 ENOG4105CP7 Triose-phosphate isomerase FLQ13_04020 ENOG4105BZA Phosphoglycerate kinase FLQ13_04025 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FLQ13_04040 ENOG4105CMD Transcriptional regulator, GntR family FLQ13_04045 ENOG4105DEN Luciferase family FLQ13_04050 ENOG4105GZI Transcriptional regulator FLQ13_04055 ENOG4107RT3 EamA-like transporter family FLQ13_04065 ENOG4105VRS hydrolase family 18 FLQ13_04070 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FLQ13_04075 ENOG4107QR9 Iron-sulfur cluster binding protein FLQ13_04080 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FLQ13_04095 ENOG4105BZU Histidine kinase FLQ13_04100 ENOG4105KCT ABC transporter FLQ13_04105 ENOG4108M15 ABC transporter FLQ13_04110 ENOG4107R6F Alpha Beta Hydrolase Fold protein FLQ13_04115 ENOG4108MJI response regulator FLQ13_04130 ENOG4105EG2 ABC transporter, permease FLQ13_04140 ENOG4107FKK extracellular solute-binding protein family 1 FLQ13_04150 ENOG4105JXH GntR family transcriptional regulator FLQ13_04155 ENOG4105DAA L-lactate FLQ13_04160 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ13_04170 ENOG4108ZPC Polysaccharide pyruvyl transferase FLQ13_04175 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FLQ13_04180 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family FLQ13_04185 ENOG4105D3Q Sugar transferase FLQ13_04195 ENOG4105K64 Glycosyl transferase, family 2 FLQ13_04205 ENOG4107QRS glycosyltransferase group 2 family protein FLQ13_04210 ENOG41068W6 Capsular polysaccharide biosynthesis protein FLQ13_04215 ENOG4108KMV Glycosyl transferase (Group 1 FLQ13_04220 ENOG4105K64 Glycosyl transferase, family 2 FLQ13_04225 ENOG4108PQP glycosyl transferase group 1 FLQ13_04235 ENOG4108QV3 biosynthesis protein FLQ13_04240 ENOG4105HTX biosynthesis protein FLQ13_04250 ENOG4105EBR Carboxylesterase FLQ13_04260 ENOG4105PY6 Phenolic acid decarboxylase FLQ13_04265 ENOG4105NI3 Protein of unknown function (DUF3237) FLQ13_04275 ENOG4105FQP Beta-lactamase FLQ13_04285 ENOG4108UXE Protein tyrosine phosphatase FLQ13_04295 ENOG41082YX Transcriptional regulator, arsr family FLQ13_04300 ENOG4105EDQ levansucrase EC 2.4.1.10 FLQ13_04305 ENOG4108HKT sucrose-6-phosphate hydrolase FLQ13_04310 ENOG4107QTZ amino acid FLQ13_04335 ENOG4105DNP FAD linked oxidase domain protein FLQ13_04345 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FLQ13_04350 ENOG4108URH decarboxylase FLQ13_04355 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain FLQ13_04360 ENOG4105CHH sulfate transporter FLQ13_04365 ENOG4108V2W Carbonate dehydratase FLQ13_04370 ENOG4105C5I Dehydrogenase FLQ13_04380 ENOG4105C19 ABC transporter FLQ13_04385 ENOG4105EWM Histidine kinase FLQ13_04395 ENOG4107A6P FLQ13_04400 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FLQ13_04405 ENOG4105KRI phosphocarrier protein (HPr FLQ13_04410 ENOG4105CIE May be required for sporulation (By similarity) FLQ13_04420 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FLQ13_04425 ENOG4108Z4K mutator MutT protein FLQ13_04430 ENOG4105C3M thioredoxin reductase FLQ13_04445 ENOG4105BZ1 (ABC) transporter FLQ13_04455 ENOG4106FGC FLQ13_04465 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FLQ13_04470 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FLQ13_04480 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FLQ13_04485 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FLQ13_04490 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FLQ13_04495 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FLQ13_04500 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FLQ13_04510 ENOG4108E16 pectate lyase FLQ13_04515 ENOG4108S4C acetyltransferase FLQ13_04520 ENOG4107XGZ Hydrolase FLQ13_04530 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FLQ13_04535 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FLQ13_04540 ENOG4105CE4 GlcNAc 6-P deacetylase FLQ13_04545 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FLQ13_04550 ENOG4105FDP GntR family transcriptional regulator FLQ13_04555 ENOG41088CQ domain protein FLQ13_04570 ENOG41086DT Membrane protein of unknown function FLQ13_04575 ENOG41067S9 phage shock protein C, PspC FLQ13_04580 ENOG4108PY7 FLQ13_04595 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FLQ13_04600 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FLQ13_04635 ENOG4105CN1 protease FLQ13_04640 ENOG4105CRP Part of the ABC transporter FtsEX involved in FLQ13_04645 ENOG4105CAK Cell division ATP-binding protein ftsE FLQ13_04670 ENOG4105MS2 ribosomal subunit Interface protein FLQ13_04685 ENOG4105MQ3 flagellar protein FliS FLQ13_04690 ENOG4107RT6 flagellar hook-associated FLQ13_04695 ENOG41083S7 flagellar protein FlaG FLQ13_04700 ENOG4105I03 Flagellin FLQ13_04705 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FLQ13_04710 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) FLQ13_04715 ENOG4105MKD FLQ13_04720 ENOG4105DTJ flagellar hook-associated protein FLQ13_04725 ENOG4105E1Q flagellar hook-associated protein FLQ13_04740 ENOG4105RU3 FLQ13_04745 ENOG41081UC Inherit from COG: Competence protein FLQ13_04765 ENOG4105WH1 Two component transcriptional regulator luxr family FLQ13_04770 ENOG4105BZU Histidine kinase FLQ13_04775 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FLQ13_04780 ENOG4108KGH TRANSCRIPTIONal FLQ13_04785 ENOG4105ESV Glycosyl transferase, family 4 FLQ13_04790 ENOG4107EF8 Glycosyl transferase (Group 1 FLQ13_04805 ENOG4105QZI O-Antigen Polymerase FLQ13_04810 ENOG4105C6Y Udp-glucose 6-dehydrogenase FLQ13_04815 ENOG4107RA4 Glycosyl transferase (Group 1 FLQ13_04825 ENOG4105D3Q Sugar transferase FLQ13_04830 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FLQ13_04835 ENOG4105JFG SpoIID LytB domain protein FLQ13_04850 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FLQ13_04875 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FLQ13_04880 ENOG4105EY8 ABC transporter FLQ13_04890 ENOG4107VDP teichoic acid biosynthesis FLQ13_04895 ENOG4107VDP teichoic acid biosynthesis FLQ13_04900 ENOG41088M2 Glycosyl transferase family 2 FLQ13_04950 ENOG4105DG6 mannose-6-phosphate isomerase FLQ13_04965 ENOG4108NHD germination protein FLQ13_04970 ENOG4105C54 Major Facilitator superfamily FLQ13_04975 ENOG4108KGH TRANSCRIPTIONal FLQ13_04980 ENOG4105J7I hydrolase FLQ13_04985 ENOG4105K4H Nlp p60 protein FLQ13_04995 ENOG4105PNM synthesis protein FLQ13_05005 ENOG4105N98 Capsule biosynthesis protein capB FLQ13_05015 ENOG4108RVA ribokinase FLQ13_05020 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FLQ13_05025 ENOG4105C2J ABC transporter FLQ13_05030 ENOG4105CNN ABC, transporter FLQ13_05035 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FLQ13_05050 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FLQ13_05055 ENOG4107FQX Alpha-acetolactate decarboxylase FLQ13_05065 ENOG4107RSM transcriptional regulator FLQ13_05080 ENOG4106UIA FLQ13_05095 ENOG4107XC4 flavin reductase domain protein, FMN-binding FLQ13_05100 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FLQ13_05115 ENOG4105UP7 3-epimerase FLQ13_05125 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FLQ13_05135 ENOG4105CAH Chromate FLQ13_05140 ENOG4105FGV Chromate FLQ13_05150 ENOG4108WS4 fmn reductase FLQ13_05155 ENOG4107V2S Transcriptional regulator FLQ13_05160 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FLQ13_05220 ENOG4105C6Y Udp-glucose 6-dehydrogenase FLQ13_05225 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FLQ13_05230 ENOG4107YJ4 chain length determinant protein FLQ13_05235 ENOG4105HTX biosynthesis protein FLQ13_05245 ENOG4105KBK Zinc finger, swim domain protein FLQ13_05250 ENOG4105C0D helicase FLQ13_05255 ENOG410667J hydrolase FLQ13_05260 ENOG4105E98 transcriptional regulator DeoR family FLQ13_05265 ENOG4105Z8H single-stranded DNA-binding protein FLQ13_05280 ENOG4108HWY Beta-lactamase FLQ13_05285 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FLQ13_05290 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FLQ13_05300 ENOG4105CGA flagellar basal-body rod protein FlgG FLQ13_05310 ENOG4105DFF Rod shape-determining protein mreb FLQ13_05315 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FLQ13_05325 ENOG4107MII Sugar-specific transcriptional regulator TrmB FLQ13_05330 ENOG4105CZM Major Facilitator FLQ13_05335 ENOG4108M26 parallel beta-helix repeat protein FLQ13_05340 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FLQ13_05345 ENOG41080V3 Major Facilitator superfamily FLQ13_05350 ENOG4105D3W isochorismatase FLQ13_05355 ENOG4107P26 FLQ13_05360 ENOG4105BZU Histidine kinase FLQ13_05370 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FLQ13_05380 ENOG4105FRN stage II sporulation protein FLQ13_05385 ENOG4107TCE N-acetyltransferase FLQ13_05405 ENOG4106BRK FLQ13_05410 ENOG4108RYK Nad-dependent epimerase dehydratase FLQ13_05415 ENOG4108Z40 Transcriptional regulator FLQ13_05425 ENOG4105KI2 Urea amidohydrolase subunit beta FLQ13_05430 ENOG4108YZ9 Urea amidohydrolase subunit gamma FLQ13_05490 ENOG4108TF4 von Willebrand factor, type A FLQ13_05500 ENOG4105JFG SpoIID LytB domain protein FLQ13_05510 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FLQ13_05520 ENOG4106778 Protein of unknown function (DUF1146) FLQ13_05530 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FLQ13_05535 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FLQ13_05540 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FLQ13_05565 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) FLQ13_05575 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FLQ13_05580 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FLQ13_05585 ENOG4108UIC UPF0340 protein FLQ13_05590 ENOG4108YZG isomerase FLQ13_05595 ENOG4107WAU Protein tyrosine phosphatase FLQ13_05600 ENOG410815N Probably functions as a manganese efflux pump (By similarity) FLQ13_05615 ENOG4108ZXQ stage ii sporulation protein r FLQ13_05630 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FLQ13_05635 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FLQ13_05640 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FLQ13_05650 ENOG4107TT2 Auxin Efflux Carrier FLQ13_05655 ENOG4105C6K Malic enzyme FLQ13_05660 ENOG4107104 thymidine kinase FLQ13_05665 ENOG41082DI 50s ribosomal protein l31 FLQ13_05670 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FLQ13_05680 ENOG4105CBT Fructose-1,6-bisphosphatase FLQ13_05685 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FLQ13_05690 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway FLQ13_05695 ENOG4105D2N Aldolase FLQ13_05700 ENOG410812K response regulator receiver protein FLQ13_05710 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FLQ13_05720 ENOG4105C1G acyl-Coa dehydrogenase FLQ13_05725 ENOG4105DF6 Fe-S oxidoreductase FLQ13_05735 ENOG4105E5J UV damage endonuclease FLQ13_05745 ENOG4105NAE bifunctional deaminase-reductase domain protein FLQ13_05755 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FLQ13_05770 ENOG4105R3A Nitrate reductase FLQ13_05775 ENOG4108IUE nitrate reductase beta subunit FLQ13_05795 ENOG4107V6Q Cyclic nucleotide-binding domain FLQ13_05805 ENOG4105C75 arginyL-tRNA synthetase FLQ13_05810 ENOG410684U Domain of unknown function (DUF1934) FLQ13_05825 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E FLQ13_05875 ENOG4107JM4 Tetratricopeptide repeat FLQ13_05885 ENOG4105CYW agmatinase FLQ13_05890 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FLQ13_05895 ENOG4105BZ4 penicillin-binding protein FLQ13_05905 ENOG4108XFG YwhD family FLQ13_05910 ENOG4108Z4T Peptidase M50 FLQ13_05915 ENOG41069HH 4-oxalocrotonate tautomerase FLQ13_05920 ENOG41067TZ transcriptional regulator, MarR family FLQ13_05925 ENOG4105C22 threonyL-tRNA synthetase FLQ13_05930 ENOG4105C57 major facilitator superfamily FLQ13_05935 ENOG41062ES Transcriptional regulator FLQ13_05945 ENOG4105DCI Phosphohydrolase FLQ13_05955 ENOG4108VCI transcription factor, rsfa family FLQ13_05960 ENOG4108RNG Permease of the drug metabolite transporter FLQ13_05965 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FLQ13_05970 ENOG4105DUM transcriptional regulator, lysR family FLQ13_05975 ENOG4108IJ2 phosphate acetyltransferase FLQ13_05990 ENOG4105CHM Aminotransferase FLQ13_06000 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase FLQ13_06005 ENOG4105CHR reductase FLQ13_06010 ENOG4106CHD Bacilysin biosynthesis protein bacB FLQ13_06015 ENOG41061WN bacilysin biosynthesis protein FLQ13_06040 ENOG4105C26 Dehydrogenase FLQ13_06045 ENOG4105D82 Glutamate dehydrogenase FLQ13_06055 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase FLQ13_06060 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FLQ13_06065 ENOG4105C1B dTDP-glucose 4-6-dehydratase FLQ13_06070 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FLQ13_06075 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG FLQ13_06080 ENOG4107TY6 Acylneuraminate cytidylyltransferase FLQ13_06090 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD FLQ13_06130 ENOG4105C26 Dehydrogenase FLQ13_06135 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FLQ13_06140 ENOG4108RJ9 Glycosyl transferase, family 2 FLQ13_06160 ENOG4105DWF phosphomethylpyrimidine kinase FLQ13_06195 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FLQ13_06200 ENOG4105DEN Luciferase family FLQ13_06205 ENOG4108DBC nitroreductase FLQ13_06230 ENOG4105BZ9 Cytochrome C oxidase, subunit I FLQ13_06235 ENOG4105E2S oxidase) subunit II FLQ13_06240 ENOG4107BMA Transglycosylase associated protein FLQ13_06250 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FLQ13_06255 ENOG4105WH5 Teichoic acid glycosylation protein FLQ13_06280 ENOG4107ZXU DSBA oxidoreductase FLQ13_06290 ENOG410650H (LipO)protein FLQ13_06295 ENOG4107SJW iron permease, FTR1 FLQ13_06300 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FLQ13_06310 ENOG4105CMU LysR family (Transcriptional regulator FLQ13_06315 ENOG4105VAW lrga family FLQ13_06320 ENOG41067MG lrgb family FLQ13_06325 ENOG4105D8G Major Facilitator superfamily FLQ13_06340 ENOG4105DR4 Methyltransferase FLQ13_06350 ENOG4108YV3 Protein of unknown function (DUF2711) FLQ13_06355 ENOG4105CK1 PTS System FLQ13_06380 ENOG4105X1N Glycosyl transferase family 8 FLQ13_06390 ENOG4105GVJ transcriptional regulator FLQ13_06395 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FLQ13_06400 ENOG4105IIU Aminopeptidase FLQ13_06410 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FLQ13_06420 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) FLQ13_06425 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FLQ13_06435 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FLQ13_06440 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FLQ13_06445 ENOG4105CM2 brancheD-chain amino acid aminotransferase FLQ13_06450 ENOG4105F8D glycoside hydrolase family 4 FLQ13_06460 ENOG4105CK1 PTS System FLQ13_06465 ENOG4105VZJ PTS System FLQ13_06470 ENOG4105EMD TRANSCRIPTIONal FLQ13_06480 ENOG4108VX5 3-methyladenine DNA glycosylase FLQ13_06485 ENOG4105CH6 catalase FLQ13_06500 ENOG4105DA5 (ABC) transporter FLQ13_06505 ENOG41069JR FLQ13_06525 ENOG4105ETS cytosine purines uracil thiamine allantoin FLQ13_06530 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FLQ13_06535 ENOG4108JJ8 (ABC) transporter FLQ13_06540 ENOG4108JJ9 ABC, transporter FLQ13_06545 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FLQ13_06550 ENOG4105C4M (Ubiquinol oxidase) subunit I FLQ13_06555 ENOG4105D2K citrate carrier protein FLQ13_06570 ENOG4107BJW polysaccharide deacetylase FLQ13_06590 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FLQ13_06615 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FLQ13_06635 ENOG4108JUB Transcriptional regulator FLQ13_06640 ENOG4105DTD Dehydrogenase FLQ13_06645 ENOG4108IIH CoA-transferase subunit B FLQ13_06650 ENOG4105D6N CoA-transferase, subunit a FLQ13_06655 ENOG4105CY2 Citrate transporter FLQ13_06660 ENOG4105DHI Methyltransferase FLQ13_06680 ENOG4105CH6 catalase FLQ13_06685 ENOG4105D4T Citrate transporter FLQ13_06695 ENOG4105CS2 ec 3.2.1.21 FLQ13_06700 ENOG4105C5Y PTS System FLQ13_06705 ENOG4105CID antiterminator FLQ13_06715 ENOG4105DEU major facilitator superfamily FLQ13_06720 ENOG4105C1J atp-dependent rna helicase FLQ13_06725 ENOG4107TDE lipolytic protein G-D-S-L family FLQ13_06795 ENOG4107YZX Universal stress protein FLQ13_06800 ENOG4105CS2 ec 3.2.1.21 FLQ13_06805 ENOG4105C5Y PTS System FLQ13_06830 ENOG4108IBT Inherit from COG: transposase FLQ13_06850 ENOG4106Z5D Glycoside Hydrolase Family 43 FLQ13_06865 ENOG4105C84 Histidine ammonia-lyase FLQ13_06870 ENOG4105CGP Urocanate hydratase FLQ13_06875 ENOG4105CI2 imidazolone-5-propionate hydrolase FLQ13_06890 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FLQ13_06895 ENOG4105D9N nucleoside FLQ13_06905 ENOG4107RHR regulatoR FLQ13_06910 ENOG4108TM9 integral membrane protein FLQ13_06920 ENOG4108PGP mmge prpd family protein FLQ13_06925 ENOG4105CH2 amidohydrolase FLQ13_06935 ENOG4108HW4 amino acid AbC transporter FLQ13_06940 ENOG4105EAB amino acid AbC transporter FLQ13_06945 ENOG4108XSB acetyltransferase, (GNAT) family FLQ13_06950 ENOG4105CPU Monooxygenase FLQ13_06960 ENOG4107QHE Choloylglycine hydrolase FLQ13_06965 ENOG410667J hydrolase FLQ13_06995 ENOG4108V5C ABC transporter FLQ13_07030 ENOG4105WZ4 isomerase FLQ13_07035 ENOG4105F0H myo-inositol catabolism protein FLQ13_07040 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FLQ13_07050 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FLQ13_07055 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FLQ13_07060 ENOG4105D7K pfkb domain protein FLQ13_07070 ENOG4105C26 Dehydrogenase FLQ13_07080 ENOG4105CPC Aldo Keto reductase FLQ13_07105 ENOG4107QNK )-transporter FLQ13_07110 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FLQ13_07120 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FLQ13_07125 ENOG4105ST3 Transcriptional regulator FLQ13_07130 ENOG4105C26 Dehydrogenase FLQ13_07145 ENOG41085PJ rdd domain containing protein FLQ13_07160 ENOG4105J7D transcriptional regulator FLQ13_07165 ENOG4107JEE Short-chain dehydrogenase reductase Sdr FLQ13_07200 ENOG4105BZW Glycerate kinase FLQ13_07205 ENOG4105G3Z GntR family transcriptional regulator FLQ13_07210 ENOG4105CMG Carbohydrate kinase FLQ13_07215 ENOG4105C6Z Gluconate FLQ13_07220 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FLQ13_07225 ENOG4105D3R alkyl hydroperoxide reductase FLQ13_07230 ENOG4108JU3 Alkyl hydroperoxide reductase FLQ13_07235 ENOG4105CS2 ec 3.2.1.21 FLQ13_07240 ENOG4105C5Y PTS System FLQ13_07245 ENOG4108S3Y transcriptional regulator FLQ13_07250 ENOG4106KKU FLQ13_07255 ENOG4108Z15 abc transporter atp-binding protein FLQ13_07275 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 FLQ13_07285 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FLQ13_07300 ENOG4105E2A Dehydrogenase FLQ13_07320 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FLQ13_07325 ENOG4105WQG acetyltransferase FLQ13_07330 ENOG410780I phosphoprotein phosphatase activity FLQ13_07340 ENOG41066UZ arginase EC 3.5.3.1 FLQ13_07345 ENOG4108IQI permease FLQ13_07350 ENOG4105C8Y Acetylornithine aminotransferase FLQ13_07355 ENOG4108JUB Transcriptional regulator FLQ13_07365 ENOG4105C0H protease FLQ13_07370 ENOG4105Q2H domain protein FLQ13_07385 ENOG4105BZU Histidine kinase FLQ13_07390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLQ13_07415 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FLQ13_07420 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ13_07425 ENOG4105CDU Replicative dna helicase FLQ13_07445 ENOG4105DJ2 Major Facilitator Superfamily FLQ13_07455 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FLQ13_07460 ENOG4105BZR domain protein FLQ13_07480 ENOG4105KVH Transcriptional regulator FLQ13_07485 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FLQ13_07515 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein FLQ13_07520 ENOG4105DDN Pentapeptide repeat-containing protein FLQ13_07525 ENOG4105D94 Major Facilitator Superfamily FLQ13_07530 ENOG4107RSM transcriptional regulator FLQ13_07535 ENOG41082BV acetyltransferase FLQ13_07545 ENOG4107V2S Transcriptional regulator FLQ13_07550 ENOG4108VP3 Lysine exporter protein (LysE YggA) FLQ13_07555 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ13_07570 ENOG4108ZHR arsR family transcriptional regulator FLQ13_07575 ENOG4108SQ9 flavin reductase domain protein, FMN-binding FLQ13_07585 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FLQ13_07610 ENOG4108IXY short-chain dehydrogenase reductase FLQ13_07615 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FLQ13_07620 ENOG4107TTQ Alpha beta hydrolase fold FLQ13_07625 ENOG4105M4P Tetr family transcriptional regulator FLQ13_07650 ENOG4108Z5V transcriptional regulator, merr family FLQ13_07655 ENOG4108UQV Membrane FLQ13_07660 ENOG41086D8 Transcriptional regulator FLQ13_07680 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FLQ13_07685 ENOG4105C7Z Conserved Protein FLQ13_07705 ENOG4105MSY salicylate hydroxylase FLQ13_07710 ENOG41068WC Domain of unknown function (DUF955) FLQ13_07745 ENOG4105C7Z Conserved Protein FLQ13_07750 ENOG4107FCW Abortive infection protein FLQ13_07760 ENOG4108UW5 maltose o-acetyltransferase FLQ13_07765 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ13_07775 ENOG4105CGK Exodeoxyribonuclease III FLQ13_07780 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FLQ13_07790 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FLQ13_07795 ENOG4105C3G gtp-binding protein FLQ13_07800 ENOG4108J2R molybdopterin oxidoreductase FLQ13_07805 ENOG4105VDK protein, conserved in bacteria FLQ13_07815 ENOG4108ZDA Sporulation protein YyaC FLQ13_07820 ENOG4105FA0 parb-like partition protein FLQ13_07825 ENOG4107QJE Chromosome Partitioning Protein FLQ13_07840 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FLQ13_07845 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FLQ13_07850 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FLQ13_07865 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FLQ13_07875 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FLQ13_07880 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FLQ13_07885 ENOG410848D S4 domain protein YaaA FLQ13_07900 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FLQ13_07910 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FLQ13_07945 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FLQ13_07955 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FLQ13_07960 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FLQ13_07965 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FLQ13_07975 ENOG4105ZMH deoxynucleoside kinase FLQ13_07985 ENOG4105VRS hydrolase family 18 FLQ13_07990 ENOG4105GTG Isochorismatase FLQ13_07995 ENOG4108Z6B deaminase FLQ13_08005 ENOG4105C6E dna polymerase iii FLQ13_08010 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FLQ13_08015 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FLQ13_08025 ENOG41067KS pro-sigma K processing FLQ13_08065 ENOG4105CDW Resistance protein FLQ13_08070 ENOG4105CXN decarboxylase FLQ13_08080 ENOG4105X0R protein from nitrogen regulatory protein P-II FLQ13_08085 ENOG4105XVJ Protein of unknown function (DUF327) FLQ13_08090 ENOG4105FA2 dna polymerase iii FLQ13_08095 ENOG4105MA4 psp1 domain protein FLQ13_08105 ENOG41060K3 Methyltransferase FLQ13_08110 ENOG4105VC4 domain protein FLQ13_08115 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FLQ13_08120 ENOG4105KRN Transcriptional regulator, abrb family FLQ13_08125 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FLQ13_08130 ENOG4105F8V Hydrolase, tatD family FLQ13_08135 ENOG41069ER domain protein FLQ13_08145 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FLQ13_08150 ENOG4105XFA sporulation peptidase YabG FLQ13_08155 ENOG4105W42 Veg protein FLQ13_08160 ENOG4105XEW small acid-soluble spore protein FLQ13_08165 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FLQ13_08170 ENOG4105DFT pur operon repressor FLQ13_08175 ENOG4105KME endoribonuclease L-psp FLQ13_08180 ENOG4105K4W Could be involved in septation (By similarity) FLQ13_08185 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FLQ13_08190 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FLQ13_08195 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FLQ13_08200 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FLQ13_08210 ENOG4108JA2 transcriptioN-repair coupling factor FLQ13_08215 ENOG4108M14 stage v sporulation protein t FLQ13_08225 ENOG4108IY2 MazG family FLQ13_08230 ENOG41082I2 s4 domain protein FLQ13_08235 ENOG4105VYY sporulation protein yabp FLQ13_08250 ENOG41060GV RNA binding s1 domain protein FLQ13_08280 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FLQ13_08285 ENOG4108UGV hypoxanthine phosphoribosyltransferase FLQ13_08290 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FLQ13_08300 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FLQ13_08310 ENOG4105C6T cysteine synthase FLQ13_08315 ENOG4105CRQ synthase (Component I) FLQ13_08320 ENOG4105DDQ anthranilate synthase FLQ13_08325 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FLQ13_08330 ENOG4105EEI dihydropteroate synthase FLQ13_08335 ENOG4105KRF dihydroneopterin aldolase FLQ13_08340 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FLQ13_08350 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FLQ13_08355 ENOG4105CRK lysyL-tRNA synthetase FLQ13_08440 ENOG4108Z0C Uvrb UvrC protein FLQ13_08445 ENOG41066A3 ATP guanido phosphotransferase FLQ13_08455 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FLQ13_08460 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FLQ13_08465 ENOG4105CTP PilT protein domain protein FLQ13_08470 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FLQ13_08475 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FLQ13_08480 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FLQ13_08485 ENOG4105D7W serine acetyltransferase FLQ13_08495 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) FLQ13_08500 ENOG4105C2N RNA methyltransferase TrmH family group 3 FLQ13_08505 ENOG4105M0M Tetracycline resistance protein FLQ13_08525 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FLQ13_08530 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FLQ13_08540 ENOG4108VZM 50s ribosomal protein L10 FLQ13_08545 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FLQ13_08550 ENOG4107Y49 methyltransferase FLQ13_08555 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FLQ13_08560 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FLQ13_08565 ENOG4105XPM ribosomal protein FLQ13_08570 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FLQ13_08575 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FLQ13_08580 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FLQ13_08585 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FLQ13_08590 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FLQ13_08595 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FLQ13_08600 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FLQ13_08605 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FLQ13_08610 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FLQ13_08615 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FLQ13_08620 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FLQ13_08625 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FLQ13_08630 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FLQ13_08635 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FLQ13_08640 ENOG41082SA 50s ribosomal protein l29 FLQ13_08645 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FLQ13_08650 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FLQ13_08660 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FLQ13_08670 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FLQ13_08675 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FLQ13_08680 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FLQ13_08685 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FLQ13_08690 ENOG4105VPB 50S ribosomal protein L30 FLQ13_08695 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FLQ13_08700 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FLQ13_08710 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FLQ13_08720 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FLQ13_08730 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FLQ13_08735 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FLQ13_08740 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FLQ13_08745 ENOG4108ZT0 50S ribosomal protein l17 FLQ13_08750 ENOG4108JJB ABC transporter FLQ13_08755 ENOG4108JJB ABC transporter FLQ13_08760 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FLQ13_08765 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FLQ13_08770 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FLQ13_08775 ENOG4108UJD 30S ribosomal protein S9 FLQ13_08780 ENOG4108I0C methyltransferase FLQ13_08795 ENOG4105D1F ATP-binding protein FLQ13_08810 ENOG4108NMV polysaccharide deacetylase FLQ13_08895 ENOG4105CHH sulfate transporter FLQ13_08905 ENOG4108SA1 esterase FLQ13_08925 ENOG410874W AraC family transcriptional regulator FLQ13_08930 ENOG4105EHZ conserved protein UCP016719 FLQ13_08935 ENOG4105D17 glycoside hydrolase, family 3 domain protein FLQ13_08955 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FLQ13_08965 ENOG4105EWC Purine nucleoside phosphorylase FLQ13_08995 ENOG4105EMN RNA polymerase sigma factor FLQ13_09005 ENOG4105C8B TIGR00159 family FLQ13_09010 ENOG4107U5W ybbr family FLQ13_09015 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FLQ13_09040 ENOG4105CVR type I restriction-modification system FLQ13_09045 ENOG4105DZR Type I site-specific deoxyribonuclease FLQ13_09055 ENOG4108TWJ NADH dehydrogenase subunit 5 FLQ13_09075 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FLQ13_09080 ENOG4105WAB arsR family transcriptional regulator FLQ13_09085 ENOG4108RWP Major Facilitator Superfamily protein FLQ13_09120 ENOG4105G0J serine threonine protein kinase FLQ13_09130 ENOG4106K80 FLQ13_09140 ENOG4106DDH Sporulation-specific SASP protein FLQ13_09150 ENOG4108HWY Beta-lactamase FLQ13_09165 ENOG4107QTZ amino acid FLQ13_09175 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FLQ13_09195 ENOG410645S MarR family Transcriptional regulator FLQ13_09200 ENOG4105DCM major facilitator superfamily FLQ13_09215 ENOG410631K Membrane FLQ13_09225 ENOG4107SCQ Iron-containing alcohol dehydrogenase FLQ13_09230 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FLQ13_09235 ENOG4108TCS Glutamyl endopeptidase FLQ13_09250 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FLQ13_09255 ENOG4107ZTW SNARE associated Golgi FLQ13_09275 ENOG4105C72 UPF0176 protein FLQ13_09285 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane FLQ13_09305 ENOG4105CM2 brancheD-chain amino acid aminotransferase FLQ13_09310 ENOG4108IQI permease FLQ13_09315 ENOG4108J5H Homocysteine s-methyltransferase FLQ13_09325 ENOG4105CSV Glutaminase FLQ13_09350 ENOG4105C26 Dehydrogenase FLQ13_09355 ENOG4105DJB Major Facilitator Superfamily FLQ13_09360 ENOG4105EQX glucarate dehydratase FLQ13_09365 ENOG41073TP transcriptional regulator FLQ13_09420 ENOG4105MUA Resistance protein FLQ13_09430 ENOG4105DGI Alkaline phosphatase FLQ13_09435 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FLQ13_09445 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FLQ13_09455 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLQ13_09460 ENOG4105J7D transcriptional regulator FLQ13_09465 ENOG4107RB3 L-asparaginase FLQ13_09480 ENOG41060AI SEC-C motif FLQ13_09490 ENOG4107Y7X LytTR FLQ13_09495 ENOG4108IUW ABC transporter FLQ13_09500 ENOG4108SDH ABC, transporter FLQ13_09505 ENOG4107SET aldo keto reductase FLQ13_09540 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FLQ13_09550 ENOG4105DSE periplasmic solute binding protein FLQ13_09555 ENOG4105DIK (ABC) transporter FLQ13_09565 ENOG4105DEN Luciferase family FLQ13_09570 ENOG4108N0M stress protein FLQ13_09575 ENOG4106FN3 tellurium resistance protein FLQ13_09580 ENOG4106FN3 tellurium resistance protein FLQ13_09585 ENOG4107TS3 membrane protein, TerC FLQ13_09600 ENOG4105DAX Pfam:DUF2983 FLQ13_09610 ENOG4108TTB tellurium resistance protein FLQ13_09620 ENOG41079KZ Major Facilitator Superfamily FLQ13_09625 ENOG4107XZQ multidrug resistance protein FLQ13_09630 ENOG4108A65 Transcriptional regulator FLQ13_09635 ENOG4108IJ7 Glycine betaine FLQ13_09640 ENOG4107SQ8 Glycine betaine FLQ13_09670 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FLQ13_09705 ENOG4105EIG urea carboxylase-associated protein 1 FLQ13_09710 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FLQ13_09715 ENOG4105I1F Resistance protein FLQ13_09725 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FLQ13_09735 ENOG41089UC methyltransferase, type 11 FLQ13_09740 ENOG4105C5Q Transcriptional regulator FLQ13_09745 ENOG4105I82 acetyl xylan esterase FLQ13_09750 ENOG410756H nucleotidyltransferase FLQ13_09760 ENOG4105C26 Dehydrogenase FLQ13_09765 ENOG4105CK7 Sodium proline symporter FLQ13_09770 ENOG4107YHD transcriptional regulator FLQ13_09780 ENOG4108PJD permease FLQ13_09790 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FLQ13_09795 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FLQ13_09800 ENOG4108IFG nitrite reductase, (NAD(P)H) FLQ13_09825 ENOG4105S7A ErfK ybiS ycfS ynhG family protein FLQ13_09835 ENOG4105CKI cobalamin synthesis protein FLQ13_09840 ENOG4105E5Q amino acid AbC transporter FLQ13_09845 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein FLQ13_09850 ENOG4105E2A Dehydrogenase FLQ13_09870 ENOG4105CS2 ec 3.2.1.21 FLQ13_09885 ENOG4105C8Q Methyl-accepting chemotaxis FLQ13_09890 ENOG41080HJ 6-phospho 3-hexuloisomerase FLQ13_09900 ENOG4105KVH Transcriptional regulator FLQ13_09905 ENOG4105CEY Amp-dependent synthetase and ligase FLQ13_09935 ENOG4105SX7 Transporter FLQ13_09960 ENOG4105CDA abc transporter atp-binding protein FLQ13_09965 ENOG4105DRP amino acid AbC transporter FLQ13_09975 ENOG4106P55 Transcriptional regulator FLQ13_09980 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FLQ13_09985 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FLQ13_09990 ENOG41069ZX FLQ13_09995 ENOG41069ZX FLQ13_10005 ENOG4105DUX Transporter FLQ13_10020 ENOG4105E1K spore germination protein FLQ13_10040 ENOG4107WD8 ABC transporter, permease FLQ13_10045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLQ13_10050 ENOG4105BZU Histidine kinase FLQ13_10075 ENOG4105CFH Aspartokinase FLQ13_10080 ENOG4105DHS permease protein FLQ13_10085 ENOG4105CM4 permease protein FLQ13_10105 ENOG4105R8C Transcriptional regulator FLQ13_10110 ENOG4108DBC nitroreductase FLQ13_10115 ENOG41067V3 Antibiotic biosynthesis monooxygenase FLQ13_10120 ENOG4105YVS arsR family transcriptional regulator FLQ13_10130 ENOG4108JPW Aminotransferase FLQ13_10135 ENOG4105C26 Dehydrogenase FLQ13_10145 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FLQ13_10150 ENOG4105KTB nuclear export factor GLE1 FLQ13_10155 ENOG4108T5E Copper resistance protein FLQ13_10160 ENOG4108ZYE Transcriptional regulator FLQ13_10185 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FLQ13_10210 ENOG4105E7W lamb ycsf family protein FLQ13_10220 ENOG4105CFM UPF0317 protein FLQ13_10225 ENOG4105P4J Allophanate hydrolase, subunit 1 FLQ13_10250 ENOG41061CK Antibiotic biosynthesis monooxygenase FLQ13_10260 ENOG4107QM2 Aldo Keto reductase FLQ13_10265 ENOG4105ETD TRANSCRIPTIONal FLQ13_10275 ENOG4105HMZ Methyltransferase FLQ13_10280 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FLQ13_10295 ENOG410606W general stress protein FLQ13_10305 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FLQ13_10310 ENOG4105VCH membrane FLQ13_10320 ENOG4105C9U ATP-dependent DNA helicase RecQ FLQ13_10335 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FLQ13_10370 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FLQ13_10375 ENOG4107BMA Transglycosylase associated protein FLQ13_10380 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) FLQ13_10385 ENOG4105EU9 FLQ13_10390 ENOG4105QVS general stress protein FLQ13_10395 ENOG41082W1 Cupin 2, conserved barrel domain protein FLQ13_10415 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FLQ13_10420 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FLQ13_10425 ENOG4108MRH transcriptional regulatory protein FLQ13_10430 ENOG4107QJT sodium dicarboxylate symporter FLQ13_10435 ENOG4106F5Q Membrane FLQ13_10445 ENOG4105CJ1 ABC, transporter FLQ13_10460 ENOG4105FDT acyl-CoA dehydrogenase FLQ13_10480 ENOG4105SZ6 Thioredoxin FLQ13_10485 ENOG4105CPF Cell wall formation (By similarity) FLQ13_10490 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FLQ13_10495 ENOG4105C1J atp-dependent rna helicase FLQ13_10500 ENOG410905X membrane-flanked domain protein FLQ13_10515 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FLQ13_10520 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FLQ13_10525 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FLQ13_10535 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FLQ13_10540 ENOG4107MMM Anti-sigma-factor antagonist FLQ13_10545 ENOG4105FUA antagonist FLQ13_10550 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FLQ13_10555 ENOG4107SGM protein serine threonine phosphatase FLQ13_10560 ENOG4105WN5 stage II sporulation protein FLQ13_10565 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FLQ13_10575 ENOG41064BQ Phosphatase FLQ13_10585 ENOG4105M5P UPF0310 protein FLQ13_10590 ENOG4105RV9 Transcriptional regulator FLQ13_10750 ENOG4105ECK Fatty Acid Desaturase FLQ13_10755 ENOG4105VEQ Cold shock protein FLQ13_10760 ENOG4105VEQ Cold shock protein FLQ13_10765 ENOG4108VJ1 Transcriptional regulator (CarD family FLQ13_10770 ENOG4105UNS Pfam:DUF419 FLQ13_10775 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ13_10800 ENOG4105CZ9 Domain of unknown function (DU1801) FLQ13_10805 ENOG4105GIG FLQ13_10820 ENOG4108U05 Transcriptional regulator FLQ13_10825 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FLQ13_10845 ENOG4108V4B ThiJ pfpI FLQ13_10865 ENOG4105T38 integral membrane protein FLQ13_10870 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FLQ13_10875 ENOG41085FC arsR family transcriptional regulator FLQ13_10880 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ13_10920 ENOG4105CGD Nad-dependent epimerase dehydratase FLQ13_10935 ENOG4105DM4 PTS System FLQ13_10940 ENOG4105DG6 mannose-6-phosphate isomerase FLQ13_10945 ENOG4108ZMQ domain protein FLQ13_10950 ENOG4107Y9U Membrane FLQ13_10960 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FLQ13_10980 ENOG4108TVJ Nitroreductase FLQ13_10985 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FLQ13_10990 ENOG4108VGI doxx family FLQ13_10995 ENOG4105XXY Thioredoxin FLQ13_11000 ENOG4105PF9 Transcriptional regulator FLQ13_11010 ENOG4105WQG acetyltransferase FLQ13_11020 ENOG4105CK5 oxidoreductase FLQ13_11025 ENOG4105ETE Transcriptional regulator (LacI family FLQ13_11035 ENOG4107TRE AP endonuclease, family 2 FLQ13_11045 ENOG4105C85 amino acid FLQ13_11055 ENOG41062A4 Transcriptional regulator FLQ13_11060 ENOG4105EYF MMPL domain protein FLQ13_11070 ENOG4108TVJ Nitroreductase FLQ13_11075 ENOG4105FS7 Transcriptional regulator FLQ13_11080 ENOG4108JCI Transcriptional regulator FLQ13_11085 ENOG4108UMN azlc family FLQ13_11100 ENOG4105C2C drug resistance transporter, Bcr CflA FLQ13_11110 ENOG4105DRR Transcriptional regulator, GntR family FLQ13_11115 ENOG4105VRS hydrolase family 18 FLQ13_11135 ENOG4105G6Z alkaline phosphatase FLQ13_11145 ENOG41090UD (LipO)protein FLQ13_11150 ENOG4105F27 Major Facilitator FLQ13_11155 ENOG4105VZJ PTS System FLQ13_11160 ENOG4105VCP PTS System FLQ13_11165 ENOG4105CK1 PTS System FLQ13_11170 ENOG4105CS2 ec 3.2.1.21 FLQ13_11175 ENOG4108TZY GntR Family Transcriptional Regulator FLQ13_11180 ENOG4105EVU fructokinase FLQ13_11185 ENOG4105DG6 mannose-6-phosphate isomerase FLQ13_11190 ENOG4105D3P Mannan endo-1,4-beta-mannosidase FLQ13_11235 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FLQ13_11240 ENOG4105K8N protein family UPF0079, ATPase FLQ13_11245 ENOG41072GX Peptidase M22 Glycoprotease FLQ13_11250 ENOG410801F ribosomal-protein-alanine acetyltransferase FLQ13_11255 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FLQ13_11260 ENOG4105C5H ABC transporter FLQ13_11265 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FLQ13_11270 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FLQ13_11275 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FLQ13_11280 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FLQ13_11290 ENOG4108TYN CAAX amino terminal protease family protein FLQ13_11295 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FLQ13_11300 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FLQ13_11315 ENOG4105PGZ NB-ARC domain FLQ13_11320 ENOG4105CPQ Dehydrogenase FLQ13_11325 ENOG4105CT4 transporter FLQ13_11335 ENOG41087YS Phage shock protein A FLQ13_11340 ENOG4105DQX Zinc finger domain FLQ13_11345 ENOG4108WV1 Pfam:DUF477 FLQ13_11355 ENOG4108ZMR Ion transport 2 domain-containing protein FLQ13_11360 ENOG4107QNK )-transporter FLQ13_11385 ENOG4107YUH hydrolase FLQ13_11400 ENOG4105C85 amino acid FLQ13_11415 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FLQ13_11445 ENOG4105C7N Xanthine uracil vitamin C permease FLQ13_11475 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FLQ13_11480 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FLQ13_11485 ENOG4105C83 adenylosuccinate lyase FLQ13_11490 ENOG4105C8V SAICAR synthetase FLQ13_11495 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FLQ13_11500 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FLQ13_11515 ENOG4105CXB phosphoribosylaminoimidazole synthetase FLQ13_11520 ENOG4108V3E phosphoribosylglycinamide formyltransferase FLQ13_11525 ENOG4105DC1 bifunctional purine biosynthesis protein purh FLQ13_11530 ENOG4105C12 Phosphoribosylglycinamide synthetase FLQ13_11545 ENOG4105DVH amino acid FLQ13_11560 ENOG4108R5T secreted protein FLQ13_11565 ENOG4105KGF protein, YerC YecD FLQ13_11570 ENOG4105CBC glutamate synthase FLQ13_11580 ENOG4105C4R Atp-dependent dna helicase FLQ13_11585 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FLQ13_11595 ENOG4105CRN Aminoglycoside phosphotransferase FLQ13_11600 ENOG4105KT7 mgtC SapB transporter FLQ13_11605 ENOG4105CK7 Sodium proline symporter FLQ13_11610 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FLQ13_11615 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FLQ13_11620 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FLQ13_11625 ENOG4108IG5 Transcriptional regulator FLQ13_11635 ENOG4105CBD Diacylglycerol kinase FLQ13_11640 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FLQ13_11705 ENOG4105CDY transcriptional regulatory protein FLQ13_11715 ENOG4105M4P Tetr family transcriptional regulator FLQ13_11720 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein FLQ13_11725 ENOG4107S9F NmrA family FLQ13_11730 ENOG4105KHM amidohydrolase 2 FLQ13_11735 ENOG4105ST3 Transcriptional regulator FLQ13_11750 ENOG4105WEF catalase FLQ13_11755 ENOG4105M18 -acetyltransferase FLQ13_11770 ENOG4105C2F Histidine kinase FLQ13_11775 ENOG4105EQD regulatoR FLQ13_11780 ENOG410769Z extracellular solute-binding protein family 1 FLQ13_11785 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FLQ13_11790 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FLQ13_11795 ENOG4105F5H Glycosyl Hydrolase Family 88 FLQ13_11805 ENOG4107TDE lipolytic protein G-D-S-L family FLQ13_11820 ENOG4105CX8 fg-gap repeat protein FLQ13_11825 ENOG4105CX8 fg-gap repeat protein FLQ13_11830 ENOG4105CPC Aldo Keto reductase FLQ13_11835 ENOG4107TDE lipolytic protein G-D-S-L family FLQ13_11845 ENOG4105EKC FLQ13_11850 ENOG4105E0S extracellular solute-binding protein family 1 FLQ13_11860 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FLQ13_11870 ENOG4105H67 Protein of unknown function (DUF421) FLQ13_11875 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FLQ13_11880 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FLQ13_11905 ENOG4106I4J membrane FLQ13_11910 ENOG41082F9 transcriptional regulator FLQ13_11920 ENOG4108R1P FLQ13_11925 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FLQ13_11930 ENOG4105E0M Sulfatase FLQ13_11935 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FLQ13_11945 ENOG41090R9 glycosyltransferase FLQ13_11950 ENOG4107R51 Glycosyl transferase, family 2 FLQ13_11955 ENOG41090R9 glycosyltransferase FLQ13_11960 ENOG4105EU0 Major facilitator Superfamily FLQ13_11970 ENOG4105CUB amino acid FLQ13_11975 ENOG4105C26 Dehydrogenase FLQ13_11980 ENOG4105FKZ Methyl-accepting chemotaxis FLQ13_11985 ENOG4105C5H ABC transporter FLQ13_11995 ENOG4107SWG transcriptional regulator MERR family FLQ13_12000 ENOG4105DXB Major Facilitator superfamily FLQ13_12010 ENOG4105C5H ABC transporter FLQ13_12015 ENOG4105FDU atp-dependent rna helicase FLQ13_12025 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FLQ13_12040 ENOG4105E6M Sulphatase-modifying factor protein FLQ13_12045 ENOG4105E0A ABC, transporter FLQ13_12055 ENOG4105DQ5 transport system permease protein FLQ13_12060 ENOG4108HUF Transporter FLQ13_12075 ENOG4108J20 pectate lyase FLQ13_12080 ENOG4107QPK )-transporter FLQ13_12105 ENOG4106WTF Glycosyl transferase, family 2 FLQ13_12110 ENOG4107RGC Glycosyl transferase, family 2 FLQ13_12120 ENOG4108MRH transcriptional regulatory protein FLQ13_12145 ENOG410855V Acylphosphatase FLQ13_12150 ENOG4108RPX mosc domain containing protein FLQ13_12170 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FLQ13_12195 ENOG4105C5Y PTS System FLQ13_12205 ENOG4107414 GntR family transcriptional regulator FLQ13_12210 ENOG4108RCM Nitroreductase FLQ13_12220 ENOG4105CGH 5'-nucleotidase FLQ13_12225 ENOG4107RKG DJ-1/PfpI family FLQ13_12240 ENOG4105KJF protein tyrosine phosphatase FLQ13_12295 ENOG4106KE4 Dehydrogenase FLQ13_12300 ENOG4105D7N magnesium and cobalt transport protein CorA FLQ13_12310 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FLQ13_12320 ENOG4105BZ1 (ABC) transporter FLQ13_12325 ENOG4105CJA serine threonine protein kinase FLQ13_12345 ENOG4105CFC Transporter FLQ13_12370 ENOG4107RUY (E1 component), alpha subunit FLQ13_12380 ENOG4107QKR Dehydrogenase FLQ13_12390 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FLQ13_12395 ENOG41069DP small acid-soluble spore protein FLQ13_12400 ENOG4105KK4 UPF0060 membrane protein FLQ13_12430 ENOG4105F8D glycoside hydrolase family 4 FLQ13_12435 ENOG4108Q3X Transcriptional regulator FLQ13_12445 ENOG4105BZ1 (ABC) transporter FLQ13_12450 ENOG4105BZ1 (ABC) transporter FLQ13_12460 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ13_12465 ENOG4105ID8 Transcriptional regulator, ARAC family FLQ13_12475 ENOG4107QP6 Xylose isomerase domain protein TIM barrel FLQ13_12480 ENOG4105CIB oxidoreductase Domain protein FLQ13_12485 ENOG4105BZU Histidine kinase FLQ13_12490 ENOG4105WH1 Two component transcriptional regulator luxr family FLQ13_12495 ENOG4105CJ1 ABC, transporter FLQ13_12500 ENOG41090VJ ABC-2 type transporter FLQ13_12505 ENOG4108KYE ABC-2 type transporter FLQ13_12510 ENOG4105U3E Transcriptional regulator FLQ13_12515 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold FLQ13_12525 ENOG4105H93 Acyltransferase family FLQ13_12530 ENOG4108YYS metal-dependent hydrolase (By similarity) FLQ13_12540 ENOG410834F Transcriptional regulator FLQ13_12550 ENOG4108MES Periplasmic binding protein FLQ13_12555 ENOG4105DQ5 transport system permease protein FLQ13_12565 ENOG4105JAB phenazine biosynthesis protein, phzf family FLQ13_12570 ENOG4107Y03 Nitroreductase FLQ13_12585 ENOG4105ECP epimerase FLQ13_12600 ENOG4105F27 Major Facilitator FLQ13_12620 ENOG4105VZ8 Transcriptional regulator FLQ13_12630 ENOG4106AKJ FLQ13_12635 ENOG4105D74 hydrolase FLQ13_12640 ENOG4105CKK Glycosyl transferase, family 2 FLQ13_12645 ENOG4105EJV Membrane FLQ13_12650 ENOG41067AE Membrane-bound metal-dependent hydrolase FLQ13_12660 ENOG4106BXE FLQ13_12665 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FLQ13_12680 ENOG4105EVI UPF0374 protein FLQ13_12685 ENOG4105BZ1 (ABC) transporter FLQ13_12690 ENOG4107NBY Membrane FLQ13_12700 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FLQ13_12705 ENOG4105G5W regulator Fur family FLQ13_12815 ENOG4108N23 SpoOM-related protein FLQ13_12825 ENOG4105E2A Dehydrogenase FLQ13_12830 ENOG4105PGS Spore coat protein FLQ13_12840 ENOG4105EC3 peptidase S51, dipeptidase E FLQ13_12845 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FLQ13_12865 ENOG4105E2Y ABC, transporter FLQ13_12870 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FLQ13_12875 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FLQ13_12880 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FLQ13_12890 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FLQ13_12895 ENOG4107D63 FLQ13_12900 ENOG4105VZ8 Transcriptional regulator FLQ13_12915 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FLQ13_12925 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FLQ13_12945 ENOG4105CYN Serine protein kinase FLQ13_12950 ENOG4106AKX UPF0229 protein FLQ13_12955 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FLQ13_12960 ENOG4105CW7 secretion protein, HlyD family FLQ13_12965 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLQ13_12970 ENOG4105CS1 NAD(P)H quinone oxidoreductase FLQ13_12985 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FLQ13_12990 ENOG4105CZV ABC transporter FLQ13_12995 ENOG4105CJ1 ABC, transporter FLQ13_13000 ENOG4108TU7 Inherit from COG: (ABC) transporter FLQ13_13005 ENOG4105VEQ Cold shock protein FLQ13_13060 ENOG4108YBP pseudouridine synthase FLQ13_13070 ENOG41080XP Cbs domain FLQ13_13075 ENOG4107YBY Hydrolase FLQ13_13080 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FLQ13_13090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FLQ13_13095 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FLQ13_13105 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FLQ13_13110 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FLQ13_13120 ENOG4105BZU Histidine kinase FLQ13_13125 ENOG4105WH1 Two component transcriptional regulator luxr family FLQ13_13160 ENOG4105ED1 spovr family FLQ13_13180 ENOG4105BZN citrate synthase FLQ13_13185 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FLQ13_13190 ENOG4105CUB amino acid FLQ13_13195 ENOG4105C8J )-transporter FLQ13_13200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FLQ13_13215 ENOG4105J37 FLQ13_13220 ENOG4108AEY RNA polymerase sigma factor FLQ13_13225 ENOG4108FN7 Aldo keto reductase FLQ13_13230 ENOG4105F6E Acyl-transferase FLQ13_13235 ENOG4107VFR oxidoreductase FLQ13_13240 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FLQ13_13245 ENOG4105C37 (CBS) domain FLQ13_13255 ENOG4105CHM Aminotransferase FLQ13_13260 ENOG4105C37 (CBS) domain FLQ13_13270 ENOG4105WMR Protein CrcB homolog FLQ13_13275 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FLQ13_13285 ENOG4105D64 Mechanosensitive ion channel FLQ13_13290 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FLQ13_13295 ENOG4107VMI polysaccharide deacetylase FLQ13_13300 ENOG4105F0I Aminotransferase FLQ13_13320 ENOG4105BZ1 (ABC) transporter FLQ13_13325 ENOG4105BZ1 (ABC) transporter FLQ13_13350 ENOG410839P FLQ13_13360 ENOG4106MP8 UPF0754 membrane protein FLQ13_13365 ENOG4105WZB UPF0342 protein FLQ13_13370 ENOG4105F1N DNA alkylation repair FLQ13_13380 ENOG4105D4P Coproporphyrinogen iii oxidase FLQ13_13385 ENOG4107S91 Sodium hydrogen exchanger FLQ13_13390 ENOG4105NCW Trka-c domain protein FLQ13_13400 ENOG4105CGU Enoyl-CoA hydratase FLQ13_13410 ENOG4108IUX (ABC) transporter FLQ13_13415 ENOG4105RHA ABC transporter, permease FLQ13_13420 ENOG4107VRP DNA repair exonuclease FLQ13_13425 ENOG4106D4I domain protein FLQ13_13430 ENOG4105EQI Metal Dependent Phosphohydrolase FLQ13_13485 ENOG4105NBU tryptophan transport protein FLQ13_13490 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FLQ13_13495 ENOG4105K59 histidine triad (HIT) protein FLQ13_13530 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FLQ13_13535 ENOG4105BZ4 penicillin-binding protein FLQ13_13540 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FLQ13_13550 ENOG4105C1Q protoporphyrinogen oxidase FLQ13_13560 ENOG4105ECB domain protein FLQ13_13570 ENOG41090T1 Membrane FLQ13_13580 ENOG4105DER m42 family FLQ13_13595 ENOG4106AXD FLQ13_13600 ENOG4108RQ5 Beta-lactamase domain-containing protein FLQ13_13605 ENOG4105DF9 Lipoate-protein, ligase FLQ13_13615 ENOG4105CEY Amp-dependent synthetase and ligase FLQ13_13625 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FLQ13_13630 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FLQ13_13645 ENOG4108HUF Transporter FLQ13_13650 ENOG4107TB6 phosphoglycerate mutase FLQ13_13670 ENOG4106YBV Methyl-accepting chemotaxis FLQ13_13695 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FLQ13_13710 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FLQ13_13725 ENOG4105ENA helicase FLQ13_13760 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FLQ13_13765 ENOG4105X3H Excalibur domain protein FLQ13_13770 ENOG4105E1V na solute symporter FLQ13_13775 ENOG4106CAD Protein of unknown function (DUF3311) FLQ13_13780 ENOG41060YP FLQ13_13800 ENOG4108INS Transcriptional regulator FLQ13_13820 ENOG4105TRI Hydrolase FLQ13_13840 ENOG4106K7D Major facilitator family transporter FLQ13_13845 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FLQ13_13850 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding FLQ13_13865 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FLQ13_13875 ENOG4105EYH Exonuclease FLQ13_13925 ENOG4105ERH Fumarylacetoacetate hydrolase FLQ13_13935 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FLQ13_13945 ENOG4105CAQ asparagine synthetase FLQ13_13965 ENOG4106HBX Transcriptional Regulator AraC Family FLQ13_13970 ENOG4105ETE Transcriptional regulator (LacI family FLQ13_13975 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FLQ13_13980 ENOG4105SF0 DinB family FLQ13_13990 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FLQ13_13995 ENOG4105MYW Pentapeptide repeat protein FLQ13_14000 ENOG4107S9D Alpha beta hydrolase FLQ13_14005 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FLQ13_14010 ENOG4107RIQ Sulfate adenylate transferase FLQ13_14015 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FLQ13_14020 ENOG4108N5B 2-phosphosulfolactate phosphatase FLQ13_14025 ENOG41061P3 phosphosulfolactate synthase FLQ13_14035 ENOG4105DIA mandelate racemase muconate lactonizing FLQ13_14040 ENOG4107RCC Major Facilitator Superfamily FLQ13_14045 ENOG4108SZE gCN5-related N-acetyltransferase FLQ13_14050 ENOG4105MA6 gCN5-related N-acetyltransferase FLQ13_14060 ENOG4108VPT UPF0234 protein FLQ13_14065 ENOG4105QNR S1 RNA binding domain protein FLQ13_14085 ENOG4105K7K Transcriptional regulator FLQ13_14095 ENOG410751J FLQ13_14100 ENOG4105D4Y metalloprotease FLQ13_14105 ENOG4105EPR degv family FLQ13_14110 ENOG4107AYK membrAne FLQ13_14120 ENOG41073B9 FLQ13_14125 ENOG4108KP7 hydrolase FLQ13_14130 ENOG4108MXZ Esterase FLQ13_14135 ENOG4105VG1 fes assembly suf system protein FLQ13_14145 ENOG4105IQ5 FAD linked oxidase domain protein FLQ13_14170 ENOG4105C8Y Acetylornithine aminotransferase FLQ13_14175 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FLQ13_14185 ENOG4105DBV ornithine carbamoyltransferase FLQ13_14210 ENOG4107RMD Basic membrane lipoprotein FLQ13_14225 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FLQ13_14230 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FLQ13_14240 ENOG4105C3U ABC transporter FLQ13_14245 ENOG4108JQ7 (ABC) transporter FLQ13_14260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLQ13_14270 ENOG4105C31 Tryptophanyl-tRNA synthetase FLQ13_14280 ENOG4108J59 Extracellular solute-binding protein, family 5 FLQ13_14285 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLQ13_14290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLQ13_14300 ENOG4108JQ7 (ABC) transporter FLQ13_14315 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FLQ13_14320 ENOG4108ZCF integral membrane protein FLQ13_14330 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis FLQ13_14340 ENOG4105DPN Oligoendopeptidase f FLQ13_14355 ENOG4105T58 Dithiol-disulfide isomerase FLQ13_14360 ENOG4108Z18 K06886 hemoglobin FLQ13_14365 ENOG4105E4C Lytic transglycosylase catalytic FLQ13_14370 ENOG4105MIX Adenylate cyclase FLQ13_14385 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FLQ13_14390 ENOG4105EMS pseudouridine synthase FLQ13_14405 ENOG4105ETU transcriptional activator (TenA FLQ13_14410 ENOG4108VEU Thiamine monophosphate synthase FLQ13_14425 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FLQ13_14430 ENOG4105D06 uba thif-type nad fad binding protein FLQ13_14435 ENOG4105DWF phosphomethylpyrimidine kinase FLQ13_14440 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FLQ13_14445 ENOG4107A88 FLQ13_14495 ENOG4105ENA helicase FLQ13_14510 ENOG4108ZMI UPF0477 protein FLQ13_14520 ENOG4105C28 cystathionine FLQ13_14530 ENOG4105D9U N-acetyltransferase FLQ13_14655 ENOG4105G7B Protein of unknown function (DUF2992) FLQ13_14660 ENOG4105VMI -acetyltransferase FLQ13_14665 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family FLQ13_14700 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FLQ13_14710 ENOG4108ZJ4 polysaccharide deacetylase FLQ13_14715 ENOG4107CUJ Protein of unknown function (DUF2690) FLQ13_14740 ENOG4108IEG Formate dehydrogenase Alpha subunit FLQ13_14765 ENOG4106A3M Cytochrome p-450 FLQ13_14770 ENOG41087PP glycosyltransferase MGT family FLQ13_14785 ENOG4105EXQ uroporphyrinogen iii synthase hem4 FLQ13_14790 ENOG4105C4B ABC transporter, permease FLQ13_14795 ENOG4108IXI (ABC) transporter FLQ13_14805 ENOG4105Q95 Cupin 2, conserved barrel domain protein FLQ13_14820 ENOG4105D2H Uronic isomerase FLQ13_14830 ENOG4105DG4 malate L-lactate dehydrogenase FLQ13_14835 ENOG4105CPQ Dehydrogenase FLQ13_14840 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FLQ13_14845 ENOG4105DMW Dehydrogenase reductase FLQ13_14850 ENOG4108I5G Major Facilitator superfamily FLQ13_14855 ENOG4107KJX Transcriptional regulator FLQ13_14860 ENOG4107QZW Altronate oxidoreductase FLQ13_14865 ENOG4105CTX dehydratase FLQ13_14870 ENOG4107TSN permease FLQ13_14890 ENOG41068K0 YCII-related domain FLQ13_14895 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FLQ13_14905 ENOG4105K7W phage-related replication protein FLQ13_14915 ENOG410635T phage-like element pbsx protein FLQ13_14960 ENOG4108TFU terminase (Small subunit) FLQ13_14965 ENOG4105IG6 Phage terminase, large subunit FLQ13_14970 ENOG4108MDF Phage Portal Protein FLQ13_14995 ENOG41060SN FLQ13_15010 ENOG4105PQS phage protein FLQ13_15015 ENOG4105FR7 XkdM protein, phage-like element PBSX FLQ13_15020 ENOG4105MTC XkdN-like protein FLQ13_15040 ENOG4105X7F FLQ13_15050 ENOG4105MFU Protein of unknown function (DUF2634) FLQ13_15055 ENOG41066EA baseplate J family protein FLQ13_15060 ENOG410906S phage-like element pbsx protein xkdt FLQ13_15100 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FLQ13_15105 ENOG4108TGC Acyltransferase FLQ13_15125 ENOG4105CJ3 phosphate transporter FLQ13_15130 ENOG4107GRR phosphate transport regulator FLQ13_15135 ENOG4107R7I amino acid FLQ13_15145 ENOG4105EDW glycosyl transferase, family 39 FLQ13_15150 ENOG4105CKK Glycosyl transferase, family 2 FLQ13_15160 ENOG4105C0H protease FLQ13_15170 ENOG4108ME1 Peptidase M55 D-aminopeptidase FLQ13_15175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLQ13_15185 ENOG4105C3U ABC transporter FLQ13_15195 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FLQ13_15200 ENOG4105DTQ mandelate racemase muconate lactonizing FLQ13_15205 ENOG4107SN7 NLP P60 protein FLQ13_15210 ENOG4108JQ7 (ABC) transporter FLQ13_15215 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FLQ13_15220 ENOG4107TUM Amidinotransferase FLQ13_15225 ENOG4108S4H thioesterase Superfamily protein FLQ13_15230 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FLQ13_15250 ENOG4108428 Inherit from COG: -acetyltransferase FLQ13_15260 ENOG41080TC multidrug resistance protein FLQ13_15265 ENOG4105CIY formyltetrahydrofolate deformylase FLQ13_15285 ENOG4105K56 Transcriptional regulator FLQ13_15290 ENOG4108ZHJ Organic hydroperoxide resistance protein FLQ13_15295 ENOG4107TVC Glycosyl transferase, family 2 FLQ13_15300 ENOG4107Y2X deaminase FLQ13_15305 ENOG4105CVJ phosphoglycerate mutase FLQ13_15310 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FLQ13_15325 ENOG4108W7F transporter, permease FLQ13_15335 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein FLQ13_15340 ENOG4108X43 YKOF domain protein FLQ13_15345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLQ13_15360 ENOG4106849 propeptide, pepSY amd peptidase M4 FLQ13_15375 ENOG4105CJW magnesium transporter FLQ13_15380 ENOG4105V75 Transcriptional regulator FLQ13_15425 ENOG4105DQE DNA ligase FLQ13_15430 ENOG4105FDF Could be involved in DNA repair (By similarity) FLQ13_15435 ENOG4105BZU Histidine kinase FLQ13_15440 ENOG4107T5V SNARE associated Golgi FLQ13_15445 ENOG4107TS3 membrane protein, TerC FLQ13_15450 ENOG4108WZW RNA polymerase sigma FLQ13_15460 ENOG410681C small acid-soluble spore protein FLQ13_15470 ENOG4105D0M Protease HtpX homolog FLQ13_15490 ENOG4108TGC Acyltransferase FLQ13_15495 ENOG4105BZU Histidine kinase FLQ13_15500 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FLQ13_15510 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FLQ13_15515 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FLQ13_15520 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FLQ13_15530 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit FLQ13_15535 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) FLQ13_15540 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FLQ13_15545 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FLQ13_15565 ENOG4105BZU Histidine kinase FLQ13_15575 ENOG41090MY MarR family Transcriptional regulator FLQ13_15580 ENOG4105ER2 Ompa motb domain protein FLQ13_15585 ENOG4105E14 MotA TolQ exbB proton channel FLQ13_15595 ENOG4108K88 Membrane FLQ13_15600 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FLQ13_15605 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase FLQ13_15610 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FLQ13_15615 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FLQ13_15620 ENOG4105FEA Spore maturation protein FLQ13_15650 ENOG4105F0V Cell wall hydrolase FLQ13_15665 ENOG4105C59 p-type ATPase FLQ13_15685 ENOG4105CID antiterminator FLQ13_15695 ENOG4105KRI phosphocarrier protein (HPr FLQ13_15700 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FLQ13_15710 ENOG4105F6S Spore photoproduct lyase FLQ13_15720 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FLQ13_15725 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FLQ13_15730 ENOG4105K4I Scp-like extracellular FLQ13_15740 ENOG4105BZU Histidine kinase FLQ13_15745 ENOG4105CHM Aminotransferase FLQ13_15755 ENOG4107R88 Chemotaxis protein (CheV) FLQ13_15760 ENOG4105UIN FLQ13_15770 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein FLQ13_15780 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FLQ13_15785 ENOG4105ESF Peptidoglycan binding domain protein FLQ13_15795 ENOG4105EPM Diguanylate phosphodiesterase FLQ13_15800 ENOG4105WEF catalase FLQ13_15805 ENOG4107IN1 Protein of unknown function (DUF1797) FLQ13_15810 ENOG4108XRC Protein of unknown function (DUF458) FLQ13_15840 ENOG4105NQC Flavodoxin FLQ13_15850 ENOG4105CH2 amidohydrolase FLQ13_15860 ENOG4105D8X mechanosensitive ion channel FLQ13_15865 ENOG4105D3R alkyl hydroperoxide reductase FLQ13_15870 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FLQ13_15885 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FLQ13_15895 ENOG4105CVM Molybdenum cofactor synthesis domain protein FLQ13_15900 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FLQ13_15905 ENOG4108ZAF Molybdopterin FLQ13_15910 ENOG41067WU Molybdopterin converting factor (Subunit 1) FLQ13_15915 ENOG4105BZ1 (ABC) transporter FLQ13_15920 ENOG4105BZ1 (ABC) transporter FLQ13_15930 ENOG4107X8C Efflux transporter RND family MFP subunit FLQ13_15935 ENOG4105C19 ABC transporter FLQ13_15940 ENOG4107RBB ABC transporter, permease FLQ13_15950 ENOG4105DE4 1-phosphofructokinase FLQ13_15960 ENOG4105C3F Signal peptidase i FLQ13_15970 ENOG4105C5H ABC transporter FLQ13_15975 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FLQ13_16000 ENOG4105BZU Histidine kinase FLQ13_16010 ENOG4107ZYR domain protein FLQ13_16020 ENOG4105CN5 Metallo-Beta-Lactamase FLQ13_16030 ENOG4108X4Q Hydrolase FLQ13_16035 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FLQ13_16055 ENOG4105CPP Dehydrogenase, E1 component FLQ13_16060 ENOG4105C7S Dehydrogenase FLQ13_16065 ENOG4107QN2 dihydrolipoyl dehydrogenase FLQ13_16080 ENOG4105CXN decarboxylase FLQ13_16085 ENOG4105WBI UPF0223 protein FLQ13_16110 ENOG4105JQZ Methyltransferase FLQ13_16150 ENOG4105CI3 gtp-binding protein typa FLQ13_16155 ENOG4105QA2 FLQ13_16170 ENOG4108IAB Phoh family FLQ13_16180 ENOG4105CSV Glutaminase FLQ13_16185 ENOG4105ZPI UPF0358 protein FLQ13_16190 ENOG4105CNI cell division protein FtsW FLQ13_16195 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FLQ13_16205 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FLQ13_16220 ENOG4105CCU oxidase (Subunit III) FLQ13_16225 ENOG41064X9 cytochrome C oxidase subunit IV FLQ13_16240 ENOG41080XQ Signal transduction protein with cbs domains FLQ13_16245 ENOG4106UY4 Inherit from COG: Scp-like extracellular FLQ13_16265 ENOG4105WUC UPF0298 protein FLQ13_16280 ENOG4105H20 Sporulation integral membrane protein YlbJ FLQ13_16285 ENOG4105D78 K07001 NTE family protein FLQ13_16290 ENOG41063PX domain protein FLQ13_16300 ENOG4105CDE UPF0348 protein FLQ13_16305 ENOG4105KNH Nucleic acid-binding protein FLQ13_16310 ENOG41067VY 50S ribosomal protein L32 FLQ13_16335 ENOG4108V6E Cell division protein mraZ FLQ13_16340 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FLQ13_16355 ENOG4105CJN penicillin-binding protein FLQ13_16360 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FLQ13_16365 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FLQ13_16370 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FLQ13_16375 ENOG4105CNI cell division protein FtsW FLQ13_16380 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FLQ13_16385 ENOG4105D4A Cell wall formation (By similarity) FLQ13_16390 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FLQ13_16395 ENOG4108R2U division initiation protein FLQ13_16405 ENOG4105K67 small basic protein FLQ13_16415 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FLQ13_16425 ENOG4105FFI sigma-e processing peptidase spoiiga FLQ13_16430 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ13_16440 ENOG4105DKW ABC transporter FLQ13_16450 ENOG4105WR5 sporulation protein, YlmC YmxH family FLQ13_16455 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FLQ13_16460 ENOG4105DFA alanine racemase domain protein FLQ13_16465 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FLQ13_16470 ENOG41067XK integral membrane protein FLQ13_16485 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FLQ13_16500 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FLQ13_16505 ENOG4105C34 Pseudouridine synthase FLQ13_16515 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FLQ13_16525 ENOG4105CXT aspartate transcarbamylase FLQ13_16535 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FLQ13_16540 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FLQ13_16545 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FLQ13_16550 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) FLQ13_16555 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FLQ13_16560 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FLQ13_16565 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FLQ13_16575 ENOG4107S4M Sulfate adenylate transferase FLQ13_16580 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FLQ13_16585 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FLQ13_16590 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FLQ13_16595 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FLQ13_16600 ENOG4105F23 Fibronectin-binding protein FLQ13_16610 ENOG4105DSJ YicC domain protein FLQ13_16615 ENOG4105KC4 UPF0296 protein FLQ13_16620 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FLQ13_16630 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FLQ13_16635 ENOG4105C25 Primosomal protein n' FLQ13_16640 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FLQ13_16645 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FLQ13_16650 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FLQ13_16655 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FLQ13_16660 ENOG4108ZF3 Phosphatase FLQ13_16665 ENOG4105D9P serine threonine protein kinase FLQ13_16670 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FLQ13_16675 ENOG4105DJV ribulose-phosphate 3-epimerase FLQ13_16680 ENOG4105FJ0 thiamine FLQ13_16690 ENOG4105VB9 50S ribosomal protein l28 FLQ13_16695 ENOG4108ZAA Alkaline-shock protein FLQ13_16700 ENOG4105DP4 dak2 domain fusion protein ylov FLQ13_16710 ENOG4105EJQ L-serine dehydratase FLQ13_16715 ENOG4105CB5 ATP-dependent DNA helicase recG FLQ13_16720 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) FLQ13_16730 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FLQ13_16735 ENOG4105CHR reductase FLQ13_16740 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FLQ13_16745 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FLQ13_16755 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FLQ13_16765 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) FLQ13_16775 ENOG4105K5M 30s ribosomal protein S16 FLQ13_16780 ENOG4108BW8 UPF0109 protein FLQ13_16790 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FLQ13_16795 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FLQ13_16800 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FLQ13_16805 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FLQ13_16810 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FLQ13_16820 ENOG4105VM1 flagellar FLQ13_16825 ENOG4105CMV Succinyl-CoA synthetase subunit beta FLQ13_16830 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FLQ13_16835 ENOG4105C79 DNA protecting protein DprA FLQ13_16840 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FLQ13_16845 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FLQ13_16850 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FLQ13_16855 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FLQ13_16860 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FLQ13_16870 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FLQ13_16875 ENOG4108ZC9 flagellar basal-body rod protein flgc FLQ13_16880 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FLQ13_16885 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FLQ13_16890 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FLQ13_16905 ENOG4106YF4 Flagellar biosynthesis chaperone FLQ13_16915 ENOG410696Y Flagellar hook-length control protein FLQ13_16920 ENOG410822I Flagellar hook capping protein FLQ13_16925 ENOG4108JQA flagellar FLQ13_16930 ENOG41068WV flagellar FlbD family protein FLQ13_16940 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FLQ13_16945 ENOG4105DD5 Flagellar motor switch protein FLQ13_16950 ENOG4107YTP response regulator receiver protein FLQ13_16960 ENOG4105CN7 Flagellar biosynthetic protein FliP FLQ13_16965 ENOG4105VS8 Flagellar biosynthetic protein fliq FLQ13_16970 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FLQ13_16975 ENOG4105D00 flagellar biosynthetic protein flhB FLQ13_16980 ENOG4105D7B Flagellar biosynthesis protein flha FLQ13_16985 ENOG4105FZW flagellar biosynthesis regulator FlhF FLQ13_17000 ENOG4105CBS Chea signal transduction histidine kinase FLQ13_17005 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis FLQ13_17020 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ13_17030 ENOG4105CE9 30S ribosomal protein S2 FLQ13_17035 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FLQ13_17045 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FLQ13_17050 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FLQ13_17055 ENOG4105KNE Phosphatidate cytidylyltransferase FLQ13_17065 ENOG4105DZP Membrane-associated zinc metalloprotease FLQ13_17070 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FLQ13_17075 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FLQ13_17080 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FLQ13_17085 ENOG4105CHV Transcription elongation factor NusA FLQ13_17090 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FLQ13_17095 ENOG4105VHM ribosomal protein FLQ13_17100 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FLQ13_17105 ENOG4105W7A Protein of unknown function (DUF503) FLQ13_17110 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FLQ13_17115 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FLQ13_17120 ENOG4105DTN riboflavin biosynthesis protein ribF FLQ13_17125 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FLQ13_17130 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FLQ13_17140 ENOG4105C1V Peptidase, M16 FLQ13_17155 ENOG4108S0H Dipicolinic acid synthetase, b subunit FLQ13_17160 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FLQ13_17170 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FLQ13_17180 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FLQ13_17195 ENOG4105FDP GntR family transcriptional regulator FLQ13_17215 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FLQ13_17220 ENOG4105XZV Protein of unknown function (DUF3243) FLQ13_17235 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FLQ13_17240 ENOG4105CEV competence damage-inducible protein FLQ13_17255 ENOG4108A04 Beta-lactamase FLQ13_17260 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) FLQ13_17265 ENOG4105D48 metallophosphoesterase FLQ13_17270 ENOG4105MCT stage V sporulation protein S FLQ13_17280 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FLQ13_17285 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FLQ13_17300 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FLQ13_17305 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FLQ13_17365 ENOG4105IIP Membrane FLQ13_17375 ENOG4108151 Beta-lactamase domain protein FLQ13_17380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FLQ13_17390 ENOG4107QKG PfaD family FLQ13_17395 ENOG41062T2 Acyl carrier protein FLQ13_17400 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase FLQ13_17405 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase FLQ13_17410 ENOG4108MGH Enoyl-CoA hydratase FLQ13_17415 ENOG4108KQ6 Enoyl-CoA hydratase FLQ13_17445 ENOG4106A3M Cytochrome p-450 FLQ13_17455 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FLQ13_17465 ENOG4105K7W phage-related replication protein FLQ13_17470 ENOG4108X3M OsmC Ohr family protein FLQ13_17495 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FLQ13_17500 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FLQ13_17520 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FLQ13_17525 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FLQ13_17530 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FLQ13_17535 ENOG4105U6W MutT NUDIX family protein FLQ13_17540 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FLQ13_17550 ENOG4106F1P AAA ATPase, central domain protein FLQ13_17555 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FLQ13_17560 ENOG4105CXI aluminum resistance protein FLQ13_17565 ENOG4105KV4 Transcriptional regulator FLQ13_17570 ENOG4105C5F glutamine synthetase FLQ13_17590 ENOG410780I phosphoprotein phosphatase activity FLQ13_17605 ENOG4108U7W acetyltransferase FLQ13_17625 ENOG4106BHF FLQ13_17640 ENOG4105UA4 acetyltransferase FLQ13_17665 ENOG4108RZ2 Glycoside hydrolase family 16 FLQ13_17705 ENOG4107T94 Endo-14-beta-xylanase FLQ13_17730 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FLQ13_17735 ENOG41073R8 VanW family FLQ13_17740 ENOG4105NX3 Membrane FLQ13_17745 ENOG4105VMP Transcriptional regulator FLQ13_17755 ENOG4108RAV Conserved protein FLQ13_17805 ENOG4105FVX FLQ13_17815 ENOG4105K7W phage-related replication protein FLQ13_17835 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FLQ13_17850 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FLQ13_17860 ENOG4108SVB resolvase FLQ13_17865 ENOG4105VPS UPF0291 protein FLQ13_17870 ENOG4105CV1 Transketolase (EC 2.2.1.1) FLQ13_17890 ENOG4107QIV Cytochrome c biogenesis protein FLQ13_17915 ENOG4107DZX Small, acid-soluble spore protein P FLQ13_17925 ENOG4108I0Z Aconitate hydratase FLQ13_17930 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FLQ13_17945 ENOG41067CD Small, acid-soluble spore protein Tlp FLQ13_17955 ENOG4105MI2 FLQ13_17960 ENOG4105W8X HesB YadR YfhF-family protein FLQ13_17965 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FLQ13_17970 ENOG4105K4P CoA-binding domain protein FLQ13_17975 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FLQ13_17995 ENOG4107QWR cellulase (EC 3.2.1.4) FLQ13_18010 ENOG4108MYR Secreted protein FLQ13_18045 ENOG4107QX3 carboxylase FLQ13_18050 ENOG4105E39 Enoyl-CoA hydratase FLQ13_18055 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FLQ13_18060 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FLQ13_18065 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FLQ13_18070 ENOG4105CEY Amp-dependent synthetase and ligase FLQ13_18075 ENOG4105C1G acyl-Coa dehydrogenase FLQ13_18090 ENOG4105F32 YngK protein FLQ13_18095 ENOG4106U2H Protein of unknown function (DUF1360) FLQ13_18110 ENOG4105C0W non-ribosomal peptide synthetase FLQ13_18125 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FLQ13_18130 ENOG4108N2V aldose 1-epimerase FLQ13_18135 ENOG4107QJQ Mate efflux family protein FLQ13_18160 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FLQ13_18165 ENOG4105SKE transcriptional Regulator LysR family FLQ13_18170 ENOG4105CB2 alcohol dehydrogenase FLQ13_18175 ENOG4105BZ8 glutamate synthase FLQ13_18180 ENOG4105CBC glutamate synthase FLQ13_18185 ENOG4105C5Q Transcriptional regulator FLQ13_18190 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FLQ13_18220 ENOG4108UB7 FLQ13_18240 ENOG4105CJ1 ABC, transporter FLQ13_18255 ENOG4107U6E carbohydrate kinase FGGY FLQ13_18260 ENOG4108M3J Dehydrogenase FLQ13_18280 ENOG4105CIB oxidoreductase Domain protein FLQ13_18285 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FLQ13_18290 ENOG4105ETE Transcriptional regulator (LacI family FLQ13_18295 ENOG4108YQE rare lipoprotein a FLQ13_18300 ENOG4105XPP Protein of unknown function (DUF1275) FLQ13_18305 ENOG4108NR7 pectate lyase FLQ13_18310 ENOG4105CHR reductase FLQ13_18350 ENOG4107Y9E nuclease FLQ13_18365 ENOG4105CMG Carbohydrate kinase FLQ13_18380 ENOG4105DSG hydrolase family 43 FLQ13_18410 ENOG4108M1A Chitin-binding protein FLQ13_18530 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FLQ13_18550 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FLQ13_18565 ENOG4108Z7R Chaperone CsaA FLQ13_18570 ENOG4105FTV AraC Family Transcriptional Regulator FLQ13_18575 ENOG4108HJF gCN5-related N-acetyltransferase FLQ13_18585 ENOG4108W8B Beta-lactamase domain protein FLQ13_18595 ENOG4105D29 Helix-turn-helix type 11 domain protein FLQ13_18605 ENOG4105KTU Transcriptional regulator, arsr family FLQ13_18615 ENOG4108SJC Membrane FLQ13_18635 ENOG4105ECK Fatty Acid Desaturase FLQ13_18640 ENOG4108ZGX Histidine kinase FLQ13_18645 ENOG4108S01 response regulator FLQ13_18655 ENOG41069ER domain protein FLQ13_18660 ENOG4105C9U ATP-dependent DNA helicase RecQ FLQ13_18670 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FLQ13_18675 ENOG4105SCY DNAK suppressor FLQ13_18690 ENOG4105C26 Dehydrogenase FLQ13_18695 ENOG4105EWU Squalene--hopene cyclase FLQ13_18700 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FLQ13_18705 ENOG4105C8J )-transporter FLQ13_18710 ENOG4105C09 Bile acid FLQ13_18715 ENOG4105C7S Dehydrogenase FLQ13_18725 ENOG4107T89 von Willebrand factor, type A FLQ13_18730 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FLQ13_18745 ENOG41087PP glycosyltransferase MGT family FLQ13_18755 ENOG4107QMU Mate efflux family protein FLQ13_18760 ENOG4106SCS STAS domain FLQ13_18780 ENOG4105FR1 rard protein FLQ13_18800 ENOG41090U3 tautomerase FLQ13_18835 ENOG4105E1V na solute symporter FLQ13_18855 ENOG4108VXD carboxy-peptidase FLQ13_18860 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FLQ13_18870 ENOG4106Z5R FLQ13_18875 ENOG410841Q phosphoesterase PA-phosphatase related protein FLQ13_18910 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FLQ13_18915 ENOG4108TSC N-acetyltransferase FLQ13_18920 ENOG4107S4Y M20 DapE family protein YgeY FLQ13_18935 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FLQ13_18975 ENOG4107T32 3-phytase (EC 3.1.3.8) FLQ13_18980 ENOG4105C5E polysaccharide biosynthesis protein FLQ13_18985 ENOG4105E0X reductase FLQ13_18990 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FLQ13_19010 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) FLQ13_19015 ENOG41090WU lipolytic protein G-D-S-L family FLQ13_19020 ENOG4108KF3 Electron transport protein SCO1 SenC FLQ13_19040 ENOG4108UT2 hemolysin iii FLQ13_19050 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FLQ13_19070 ENOG4107YX5 Pfam:DUF548 FLQ13_19075 ENOG4108Y6J UPF0403 protein FLQ13_19080 ENOG4105C01 Dihydroxy-acid dehydratase FLQ13_19095 ENOG4108V06 Glutathione peroxidase FLQ13_19100 ENOG4105CVG Homoserine O-transsuccinylase FLQ13_19140 ENOG41081VK Ribonuclease FLQ13_19180 ENOG41065KQ synthase FLQ13_19185 ENOG4105C2W permease FLQ13_19190 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FLQ13_19195 ENOG4105CTD carboxy-peptidase FLQ13_19200 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FLQ13_19210 ENOG4105D7K pfkb domain protein FLQ13_19215 ENOG4108M60 Transcriptional regulator FLQ13_19225 ENOG4105CHR reductase FLQ13_19230 ENOG4105DVT helicase FLQ13_19245 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FLQ13_19255 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FLQ13_19260 ENOG4108UKS UPF0398 protein FLQ13_19275 ENOG4107X2U Inherit from COG: Exonuclease-like protein FLQ13_19330 ENOG4105BZ4 penicillin-binding protein FLQ13_19340 ENOG4105CSM endonuclease III FLQ13_19350 ENOG4105C5S asparaginyl-tRNA synthetase FLQ13_19355 ENOG4105CHM Aminotransferase FLQ13_19365 ENOG4105YAC FLQ13_19370 ENOG4105DVT helicase FLQ13_19375 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FLQ13_19380 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FLQ13_19385 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FLQ13_19390 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FLQ13_19395 ENOG4105DJ0 Poly(A) Polymerase FLQ13_19400 ENOG4105CPK Glycosyl transferase (Group 1 FLQ13_19405 ENOG4105FJR Lmbe family FLQ13_19410 ENOG4108Z5K methylglyoxal synthase FLQ13_19415 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FLQ13_19420 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FLQ13_19425 ENOG4108JYZ YitT family FLQ13_19445 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FLQ13_19465 ENOG41068YB TPR repeat-containing protein FLQ13_19470 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FLQ13_19480 ENOG4105CIH Imidazole acetol-phosphate transaminase FLQ13_19490 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FLQ13_19495 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FLQ13_19505 ENOG4108I0Q anthranilate phosphoribosyltransferase FLQ13_19510 ENOG4105CRQ synthase (Component I) FLQ13_19515 ENOG4105KHN chorismate mutase FLQ13_19520 ENOG4105D49 3-dehydroquinate synthase FLQ13_19525 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FLQ13_19530 ENOG4105BZU Histidine kinase FLQ13_19535 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FLQ13_19545 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FLQ13_19550 ENOG4105XXQ heptaprenyl diphosphate synthase component I FLQ13_19560 ENOG4105EUJ GTP cyclohydrolase i FLQ13_19565 ENOG4105K70 DNA-binding protein FLQ13_19570 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FLQ13_19585 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FLQ13_19590 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FLQ13_19595 ENOG41065D1 FLQ13_19600 ENOG4105S2F FLQ13_19615 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FLQ13_19620 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FLQ13_19625 ENOG4105CAT Cytidine monophosphate kinase FLQ13_19640 ENOG4105MSI germination protein ypeb FLQ13_19650 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) FLQ13_19655 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FLQ13_19670 ENOG4107RGJ metallophosphoesterase FLQ13_19685 ENOG4105I7S Abortive infection protein FLQ13_19695 ENOG4105T7X FLQ13_19705 ENOG4108SAX Membrane FLQ13_19710 ENOG4108JQ1 Dehydrogenase FLQ13_19715 ENOG4105FF2 Type I DHQase FLQ13_19730 ENOG4105BZU Histidine kinase FLQ13_19735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLQ13_19740 ENOG4105CRE cytochrome C FLQ13_19755 ENOG4105FE9 pseudouridine synthase FLQ13_19765 ENOG4108JIC nucleoside recognition domain protein FLQ13_19770 ENOG4105DZ1 carboxypeptidase FLQ13_19780 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FLQ13_19785 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FLQ13_19805 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FLQ13_19810 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FLQ13_19815 ENOG4108R6K riboflavin synthase, subunit alpha FLQ13_19820 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FLQ13_19830 ENOG4105C3F Signal peptidase i FLQ13_19835 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) FLQ13_19840 ENOG4107ZE5 PPIases accelerate the folding of proteins FLQ13_19845 ENOG4105PTM secreted protein FLQ13_19850 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FLQ13_19860 ENOG4105G6R Stage v sporulation protein ae FLQ13_19870 ENOG4105CZ3 stage V sporulation protein ad FLQ13_19875 ENOG41090VF Stage v sporulation protein ac FLQ13_19890 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ13_19895 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FLQ13_19900 ENOG41082AN stage II sporulation protein FLQ13_19905 ENOG4105DZ1 carboxypeptidase FLQ13_19910 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FLQ13_19915 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FLQ13_19920 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FLQ13_19935 ENOG4105MZ9 stage II sporulation protein m FLQ13_19955 ENOG4108IJ0 Aspartate ammonia-lyase FLQ13_19960 ENOG4105HDK L-asparaginase FLQ13_19965 ENOG4108IMY Transcriptional regulator FLQ13_19975 ENOG4108YZ4 nudix hydrolase FLQ13_19985 ENOG4105CPC Aldo Keto reductase FLQ13_20005 ENOG4106HZJ FLQ13_20010 ENOG4105RHY Pfam:UPF0157 FLQ13_20015 ENOG4105KAC Antibiotic biosynthesis monooxygenase FLQ13_20020 ENOG4108XET gCN5-related N-acetyltransferase FLQ13_20030 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FLQ13_20040 ENOG4105E5W Transporter FLQ13_20045 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ13_20060 ENOG4108IXY short-chain dehydrogenase reductase FLQ13_20065 ENOG41069FQ Metallo-beta-lactamase superfamily FLQ13_20070 ENOG4105II7 pyrroline-5-carboxylate reductase FLQ13_20080 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FLQ13_20090 ENOG410861F 50S ribosomal protein L33 FLQ13_20095 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FLQ13_20100 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FLQ13_20110 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FLQ13_20115 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FLQ13_20125 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) FLQ13_20130 ENOG4108NA0 Uncharacterized conserved protein (COG2071) FLQ13_20135 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FLQ13_20140 ENOG4108HNZ carboxyl transferase FLQ13_20145 ENOG4108ZVT methylmalonyl-coA epimerase FLQ13_20150 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FLQ13_20155 ENOG4108QEG Membrane FLQ13_20160 ENOG4105CDA abc transporter atp-binding protein FLQ13_20165 ENOG4105E5Q amino acid AbC transporter FLQ13_20170 ENOG4108HW3 (ABC) transporter FLQ13_20175 ENOG4108Y6J UPF0403 protein FLQ13_20180 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FLQ13_20195 ENOG4105C7S Dehydrogenase FLQ13_20200 ENOG4105CPP Dehydrogenase, E1 component FLQ13_20215 ENOG4105CKM Branched-chain carboxylic acid kinase FLQ13_20220 ENOG4107RDP Dehydrogenase FLQ13_20235 ENOG4106CCJ Protein of unknown function (DUF2627) FLQ13_20240 ENOG4105CR4 methylisocitrate lyase FLQ13_20255 ENOG4105C1G acyl-Coa dehydrogenase FLQ13_20260 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FLQ13_20270 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FLQ13_20275 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FLQ13_20290 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FLQ13_20300 ENOG4107QQR Sporulation FLQ13_20305 ENOG4105S1Z Stage IV sporulation protein B FLQ13_20310 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FLQ13_20315 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FLQ13_20320 ENOG4105DX0 Hemolysin A FLQ13_20335 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FLQ13_20345 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FLQ13_20350 ENOG4105M7K Involved in the transcription termination process (By similarity) FLQ13_20355 ENOG4108ZSR alkaline shock protein FLQ13_20360 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FLQ13_20380 ENOG410644B Stage III sporulation protein af FLQ13_20390 ENOG4105KQ4 Stage iii sporulation protein ad FLQ13_20395 ENOG4108CQH stage III sporulation protein AC FLQ13_20400 ENOG4105KR5 Stage iii sporulation protein FLQ13_20405 ENOG4105CD2 stage iii sporulation protein aa FLQ13_20415 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FLQ13_20420 ENOG4105DC7 peptidase M24 FLQ13_20425 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FLQ13_20435 ENOG4105CBJ Metal-dependent enzyme FLQ13_20450 ENOG4105KST dependent repressor FLQ13_20455 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FLQ13_20460 ENOG4105WZW rhodanese family FLQ13_20465 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FLQ13_20470 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FLQ13_20475 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FLQ13_20480 ENOG4105C0D helicase FLQ13_20495 ENOG4108IMY Transcriptional regulator FLQ13_20505 ENOG4105VFR signal peptidase FLQ13_20560 ENOG41080XP Cbs domain FLQ13_20570 ENOG4105C37 (CBS) domain FLQ13_20635 ENOG4107ZXI Rhomboid family FLQ13_20645 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FLQ13_20650 ENOG4105WDJ 50S ribosomal protein L33 FLQ13_20670 ENOG41068DG YceG-like family FLQ13_20680 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FLQ13_20685 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FLQ13_20690 ENOG4105E2Z phosphate ABC transporter (Permease FLQ13_20695 ENOG4105C8U phosphate abc transporter FLQ13_20700 ENOG4105CVA phosphate FLQ13_20705 ENOG4107RF6 penicillin-binding protein FLQ13_20715 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FLQ13_20720 ENOG4105SXS Protein of unknown function (DUF456) FLQ13_20735 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FLQ13_20740 ENOG41063Y9 FLQ13_20745 ENOG4108U5J '-nucleotidase FLQ13_20750 ENOG4105N80 Ferric uptake regulator, Fur family FLQ13_20755 ENOG4108JYZ YitT family FLQ13_20760 ENOG41069ZM Protein of unknown function (DUF2624) FLQ13_20765 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FLQ13_20780 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FLQ13_20785 ENOG4105EGD dinuclear metal center protein, YbgI family FLQ13_20800 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ13_20805 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FLQ13_20810 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 FLQ13_20815 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FLQ13_20825 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FLQ13_20830 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FLQ13_20835 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FLQ13_20845 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FLQ13_20850 ENOG4105KG3 cytidine deaminase FLQ13_20855 ENOG4107YR5 Diacylglycerol kinase FLQ13_20860 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FLQ13_20865 ENOG4105CTJ Metal Dependent Phosphohydrolase FLQ13_20870 ENOG4105C9A Phoh family FLQ13_20875 ENOG4105EI1 sporulation protein yqfd FLQ13_20880 ENOG41068P3 sporulation protein YqfC FLQ13_20895 ENOG4105F7J membrane-bound serine protease FLQ13_20900 ENOG4105KTH gatB Yqey FLQ13_20915 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FLQ13_20920 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FLQ13_20925 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FLQ13_20935 ENOG4105CFG Acts as a chaperone (By similarity) FLQ13_20940 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FLQ13_20945 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FLQ13_20950 ENOG4105CSA Coproporphyrinogen iii oxidase FLQ13_20955 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FLQ13_20965 ENOG4108ZRV stage ii sporulation protein p FLQ13_20970 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) FLQ13_20975 ENOG41082YS Binds directly to 16S ribosomal RNA FLQ13_20980 ENOG4105TQK DNA polymerase iii, delta' subunit FLQ13_20995 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FLQ13_21000 ENOG4108UK2 deaminase FLQ13_21005 ENOG4105KQC Competence protein FLQ13_21015 ENOG4108D32 Methyltransferase FLQ13_21025 ENOG4108WF2 Metal Dependent Phosphohydrolase FLQ13_21030 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FLQ13_21035 ENOG410812S Rna-binding protein FLQ13_21040 ENOG4105E2X shikimate dehydrogenase FLQ13_21045 ENOG4105CQW ribosome biogenesis GTPase YqeH FLQ13_21050 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FLQ13_21065 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FLQ13_21070 ENOG41080BT SNARE associated Golgi FLQ13_21085 ENOG4105WFK nuclease FLQ13_21090 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ13_21120 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FLQ13_21135 ENOG4107XZQ multidrug resistance protein FLQ13_21145 ENOG4105H3G oxidoreductase FLQ13_21150 ENOG4105PGM cation diffusion facilitator family transporter FLQ13_21180 ENOG41087NI Sulfite exporter TauE/SafE FLQ13_21185 ENOG4105VFE sira family FLQ13_21190 ENOG4107TPS domain protein FLQ13_21200 ENOG4105VFE sira family FLQ13_21205 ENOG4105C72 UPF0176 protein FLQ13_21215 ENOG4105XTG Pfam:DUF156 FLQ13_21230 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FLQ13_21240 ENOG4106ANW SMI1_KNR4 FLQ13_21265 ENOG41064BW Protein of unknown function (DUF2568)