locus-tag	class	description
NPA28_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NPA28_00010	COG0592	DNA-directed DNA polymerase activity
NPA28_00015	COG2501	S4 domain
NPA28_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NPA28_00030	COG0187	DNA topoisomerase II activity
NPA28_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NPA28_00070	COG0516	GMP reductase activity
NPA28_00070	COG0517	IMP dehydrogenase activity
NPA28_00075	COG1686	Belongs to the peptidase S11 family
NPA28_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NPA28_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NPA28_00100	COG1428	Deoxynucleoside kinase
NPA28_00105	COG1428	Deoxynucleoside kinase
NPA28_00110	COG1388	LysM domain
NPA28_00110	COG3858	chitin binding
NPA28_00115	COG1335	isochorismatase
NPA28_00120	COG0590	tRNA wobble adenosine to inosine editing
NPA28_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NPA28_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NPA28_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NPA28_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
NPA28_00190	COG3853	Toxic anion resistance protein (TelA)
NPA28_00195	COG1982	Orn Lys Arg decarboxylase major
NPA28_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NPA28_00205	COG3870	Protein conserved in bacteria
NPA28_00210	COG1728	Protein conserved in bacteria
NPA28_00215	COG0470	DNA polymerase III
NPA28_00220	COG1774	PSP1 C-terminal conserved region
NPA28_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NPA28_00235	COG2827	Endonuclease containing a URI domain
NPA28_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NPA28_00245	COG2002	toxin-antitoxin pair type II binding
NPA28_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPA28_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPA28_00255	COG0084	hydrolase, TatD family'
NPA28_00260	COG3583	domain protein
NPA28_00260	COG3584	3D domain protein
NPA28_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NPA28_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NPA28_00280	COG4466	Protein conserved in bacteria
NPA28_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NPA28_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NPA28_00300	COG0251	oxidation-reduction process
NPA28_00305	COG2088	sporulation resulting in formation of a cellular spore
NPA28_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NPA28_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NPA28_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NPA28_00325	COG0193	aminoacyl-tRNA hydrolase activity
NPA28_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NPA28_00340	COG2002	toxin-antitoxin pair type II binding
NPA28_00345	COG2244	polysaccharide biosynthetic process
NPA28_00350	COG3956	TIGRFAM MazG family protein
NPA28_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NPA28_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NPA28_00375	COG1098	S1 RNA binding domain
NPA28_00390	COG2208	phosphoserine phosphatase activity
NPA28_00395	COG2304	oxidoreductase activity
NPA28_00400	COG0515	serine threonine protein kinase
NPA28_00405	COG0037	tRNA processing
NPA28_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NPA28_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NPA28_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NPA28_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NPA28_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NPA28_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NPA28_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NPA28_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
NPA28_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NPA28_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NPA28_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NPA28_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NPA28_00470	COG1396	sequence-specific DNA binding
NPA28_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NPA28_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NPA28_00560	COG4463	regulation of RNA biosynthetic process
NPA28_00565	COG3880	PFAM UvrB UvrC protein
NPA28_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
NPA28_00575	COG0542	response to heat
NPA28_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NPA28_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NPA28_00590	COG4956	integral membrane protein (PIN domain superfamily)
NPA28_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NPA28_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NPA28_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NPA28_00610	COG1045	serine acetyltransferase
NPA28_00615	COG0215	cysteine-tRNA ligase activity
NPA28_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NPA28_00630	COG3688	RNA-binding protein containing a PIN domain
NPA28_00635	COG1595	DNA-templated transcription, initiation
NPA28_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NPA28_00650	COG0250	Participates in transcription elongation, termination and antitermination
NPA28_00660	COG0081	regulation of translation
NPA28_00675	COG2813	Specifically methylates the guanine in position
NPA28_00680	COG0085	RNA polymerase activity
NPA28_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NPA28_00690	COG1358	cellular component organization or biogenesis
NPA28_00700	COG0049	tRNA binding
NPA28_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NPA28_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NPA28_00715	COG0596	Alpha beta hydrolase
NPA28_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NPA28_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NPA28_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NPA28_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NPA28_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NPA28_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NPA28_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NPA28_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NPA28_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NPA28_00820	COG0200	Binds to the 23S rRNA
NPA28_00825	COG0201	protein transport
NPA28_00830	COG0563	adenylate kinase activity
NPA28_00835	COG0024	Methionine aminopeptidase
NPA28_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NPA28_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NPA28_00865	COG0202	RNA polymerase activity
NPA28_00870	COG0203	ribosomal protein L17
NPA28_00875	COG1122	ATPase activity
NPA28_00880	COG1122	ATPase activity
NPA28_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NPA28_00890	COG0101	tRNA pseudouridine synthase activity
NPA28_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NPA28_00905	COG2226	methyltransferase
NPA28_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPA28_00920	COG0489	protein tyrosine kinase activity
NPA28_00930	COG2194	sulfuric ester hydrolase activity
NPA28_00935	COG0726	polysaccharide deacetylase
NPA28_01015	COG0659	secondary active sulfate transmembrane transporter activity
NPA28_01020	COG0385	Bile acid
NPA28_01025	COG2819	hydrolase of the alpha beta superfamily
NPA28_01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA28_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA28_01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA28_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA28_01045	COG2207	Transcriptional regulator
NPA28_01050	COG3876	Protein conserved in bacteria
NPA28_01055	COG1472	Belongs to the glycosyl hydrolase 3 family
NPA28_01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NPA28_01065	COG1263	PTS System
NPA28_01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA28_01070	COG1737	Transcriptional regulator
NPA28_01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NPA28_01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA28_01085	COG1683	Conserved Protein
NPA28_01115	COG1595	DNA-templated transcription, initiation
NPA28_01120	COG5662	AntiSigma factor
NPA28_01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NPA28_01130	COG4856	YbbR-like protein
NPA28_01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NPA28_01150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NPA28_01155	COG3002	Belongs to the UPF0753 family
NPA28_01160	COG0288	reversible hydration of carbon dioxide
NPA28_01170	COG5609	conserved protein (DUF2294)
NPA28_01175	COG0640	Transcriptional regulator
NPA28_01180	COG2814	Major facilitator Superfamily
NPA28_01200	COG0596	Alpha beta hydrolase
NPA28_01205	COG0745	RESPONSE REGULATOR receiver
NPA28_01210	COG0642	Histidine kinase
NPA28_01220	COG0515	serine threonine protein kinase
NPA28_01235	COG1113	amino acid transport
NPA28_01250	COG2602	Beta-lactamase
NPA28_01255	COG2124	cytochrome p450
NPA28_01265	COG0531	amino acid
NPA28_01270	COG0584	glycerophosphoryl diester phosphodiesterase
NPA28_01275	COG2271	Major facilitator Superfamily
NPA28_01285	COG0456	acetyltransferase
NPA28_01285	COG1846	Transcriptional regulator
NPA28_01290	COG2271	Major facilitator Superfamily
NPA28_01300	COG3409	Peptidoglycan-binding domain 1 protein
NPA28_01310	COG0371	Dehydrogenase
NPA28_01315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NPA28_01320	COG3591	Belongs to the peptidase S1B family
NPA28_01330	COG0596	Alpha beta hydrolase
NPA28_01335	COG1183	phosphatidylcholine synthase activity
NPA28_01340	COG0586	Pfam SNARE associated Golgi protein
NPA28_01345	COG0688	phosphatidylethanolamine metabolic process
NPA28_01355	COG2312	Erythromycin esterase
NPA28_01360	COG2207	Transcriptional regulator
NPA28_01365	COG1054	Belongs to the UPF0176 family
NPA28_01370	COG1301	dicarboxylic acid transport
NPA28_01375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA28_01375	COG2190	(PTS) system
NPA28_01375	COG1263	PTS System
NPA28_01380	COG0363	glucosamine-6-phosphate deaminase activity
NPA28_01385	COG2188	Transcriptional regulator
NPA28_01395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NPA28_01400	COG0833	amino acid
NPA28_01405	COG2040	homocysteine
NPA28_01410	COG1115	amino acid carrier protein
NPA28_01415	COG2066	Belongs to the glutaminase family
NPA28_01420	COG4191	Histidine kinase
NPA28_01425	COG0784	Response regulator, receiver
NPA28_01430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NPA28_01435	COG1012	belongs to the aldehyde dehydrogenase family
NPA28_01440	COG2271	Major facilitator Superfamily
NPA28_01445	COG4948	Mandelate Racemase Muconate Lactonizing
NPA28_01450	COG2186	Transcriptional regulator
NPA28_01455	COG2721	sulfolactate sulfo-lyase activity
NPA28_01460	COG3173	Aminoglycoside phosphotransferase
NPA28_01470	COG0697	spore germination
NPA28_01475	COG0745	RESPONSE REGULATOR receiver
NPA28_01480	COG2205	protein histidine kinase activity
NPA28_01485	COG1131	(ABC) transporter
NPA28_01510	COG3773	Cell wall hydrolase
NPA28_01515	COG2304	oxidoreductase activity
NPA28_01525	COG3540	Alkaline phosphatase
NPA28_01530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NPA28_01535	COG0805	protein transport
NPA28_01540	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NPA28_01545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NPA28_01550	COG0477	Major facilitator Superfamily
NPA28_01555	COG1309	transcriptional regulator
NPA28_01560	COG0252	asparaginase activity
NPA28_01565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NPA28_01570	COG1714	RDD family
NPA28_01575	COG3012	SEC-C Motif Domain Protein
NPA28_01575	COG1405	negative regulation of cell septum assembly
NPA28_01580	COG3290	protein histidine kinase activity
NPA28_01585	COG3279	Response regulator of the LytR AlgR family
NPA28_01590	COG4555	ABC transporter
NPA28_01595	COG1668	transmembrane transport
NPA28_01600	COG0667	Aldo Keto reductase
NPA28_01615	COG1595	DNA-templated transcription, initiation
NPA28_01620	COG1595	DNA-templated transcription, initiation
NPA28_01625	COG1876	peptidase activity
NPA28_01630	COG0457	Tetratricopeptide repeat
NPA28_01635	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_01640	COG0366	Alpha amylase catalytic
NPA28_01645	COG0803	Belongs to the bacterial solute-binding protein 9 family
NPA28_01650	COG1121	(ABC) transporter
NPA28_01655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NPA28_01660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NPA28_01665	COG2310	stress, protein
NPA28_01670	COG2310	stress, protein
NPA28_01675	COG2310	stress, protein
NPA28_01680	COG0861	Integral membrane protein TerC family
NPA28_01695	COG1358	cellular component organization or biogenesis
NPA28_01710	COG3853	Toxic anion resistance protein (TelA)
NPA28_01715	COG0477	Major facilitator Superfamily
NPA28_01720	COG2814	Major facilitator Superfamily
NPA28_01725	COG0640	Transcriptional regulator
NPA28_01730	COG4175	Glycine betaine
NPA28_01730	COG0517	IMP dehydrogenase activity
NPA28_01735	COG4176	ABC-type proline glycine betaine transport system permease component
NPA28_01740	COG2113	Glycine betaine
NPA28_01745	COG1473	amidohydrolase
NPA28_01750	COG1288	antiporter activity
NPA28_01760	COG0366	Alpha amylase catalytic
NPA28_01765	COG0039	L-malate dehydrogenase activity
NPA28_01770	COG1620	l-lactate permease
NPA28_01775	COG2814	Major facilitator Superfamily
NPA28_01780	COG1846	Transcriptional regulator
NPA28_01785	COG1280	lysine exporter protein (LysE YggA)
NPA28_01790	COG3403	YqcI/YcgG family
NPA28_01795	COG1113	amino acid transport
NPA28_01800	COG3665	Urea carboxylase-associated protein
NPA28_01805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NPA28_01820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NPA28_01830	COG3458	cephalosporin-C deacetylase activity
NPA28_01835	COG3541	Predicted nucleotidyltransferase
NPA28_01840	COG0506	proline dehydrogenase activity
NPA28_01845	COG1012	belongs to the aldehyde dehydrogenase family
NPA28_01850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NPA28_01855	COG2508	Transcriptional regulator
NPA28_01860	COG3689	TIGRFAM TIGR03943 family protein
NPA28_01865	COG0701	Predicted permease
NPA28_01870	COG0492	ferredoxin-NADP+ reductase activity
NPA28_01875	COG1587	Uroporphyrinogen-III synthase
NPA28_01875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NPA28_01880	COG2146	nitrite reductase [NAD(P)H] activity
NPA28_01885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NPA28_01890	COG0243	molybdopterin cofactor binding
NPA28_01895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NPA28_01900	COG2223	nitrite transmembrane transporter activity
NPA28_01905	COG1469	GTP cyclohydrolase I activity
NPA28_01910	COG1376	ErfK ybiS ycfS ynhG family protein
NPA28_01925	COG0523	cobalamin synthesis protein
NPA28_01930	COG0765	amino acid transport
NPA28_01935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA28_01940	COG1063	alcohol dehydrogenase
NPA28_01955	COG1846	Transcriptional regulator
NPA28_01965	COG3842	ATPase activity
NPA28_01970	COG2723	6-phospho-beta-galactosidase activity
NPA28_01980	COG3209	COG3209 Rhs family protein
NPA28_01985	COG0840	transmembrane signaling receptor activity
NPA28_01985	COG3290	protein histidine kinase activity
NPA28_01990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NPA28_01995	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NPA28_02000	COG1733	regulation of RNA biosynthetic process
NPA28_02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_02035	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NPA28_02040	COG2814	Major facilitator Superfamily
NPA28_02050	COG0697	spore germination
NPA28_02055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPA28_02065	COG2364	Membrane
NPA28_02070	COG1126	abc transporter atp-binding protein
NPA28_02075	COG0765	amino acid transport
NPA28_02080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA28_02085	COG0583	DNA-binding transcription factor activity
NPA28_02095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NPA28_02110	COG0596	Alpha beta hydrolase
NPA28_02115	COG3104	oligopeptide transport
NPA28_02120	COG5434	Belongs to the glycosyl hydrolase 28 family
NPA28_02130	COG0697	spore germination
NPA28_02140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NPA28_02145	COG1136	(ABC) transporter
NPA28_02150	COG0577	efflux transmembrane transporter activity
NPA28_02155	COG0745	RESPONSE REGULATOR receiver
NPA28_02160	COG3850	Histidine kinase
NPA28_02160	COG5002	protein histidine kinase activity
NPA28_02165	COG0457	Tetratricopeptide repeat
NPA28_02185	COG0527	aspartate kinase activity
NPA28_02190	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA28_02195	COG4605	iron ion homeostasis
NPA28_02200	COG4604	ABC transporter, ATP-binding protein
NPA28_02205	COG4607	ABC-type enterochelin transport system periplasmic component
NPA28_02210	COG2814	Major facilitator Superfamily
NPA28_02215	COG1309	transcriptional regulator
NPA28_02220	COG0778	Nitroreductase
NPA28_02225	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NPA28_02230	COG0640	Transcriptional regulator
NPA28_02235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPA28_02240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NPA28_02245	COG1012	belongs to the aldehyde dehydrogenase family
NPA28_02250	COG4975	Glucose uptake
NPA28_02255	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_02260	COG4549	nuclear export factor GLE1
NPA28_02265	COG2372	response to copper ion
NPA28_02265	COG1276	copper resistance
NPA28_02270	COG1349	DNA-binding transcription factor activity
NPA28_02280	COG2213	PTS system mannitol-specific
NPA28_02285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA28_02290	COG0246	Mannitol dehydrogenase
NPA28_02295	COG0473	3-isopropylmalate dehydrogenase activity
NPA28_02300	COG0412	Dienelactone hydrolase
NPA28_02305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NPA28_02315	COG0561	phosphatase activity
NPA28_02320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NPA28_02325	COG1914	H( )-stimulated, divalent metal cation uptake system
NPA28_02330	COG4336	lyase activity
NPA28_02335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NPA28_02340	COG1984	allophanate hydrolase subunit 2
NPA28_02345	COG1414	Transcriptional regulator
NPA28_02350	COG2755	lipolytic protein G-D-S-L family
NPA28_02360	COG2329	Antibiotic biosynthesis monooxygenase
NPA28_02365	COG0768	penicillin binding
NPA28_02370	COG4989	oxidoreductase activity
NPA28_02375	COG3711	transcriptional antiterminator
NPA28_02380	COG0318	PFAM AMP-dependent synthetase and ligase
NPA28_02385	COG2226	methyltransferase
NPA28_02390	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_02395	COG1917	Cupin 2, conserved barrel domain protein
NPA28_02400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA28_02405	COG3871	stress protein (general stress protein 26)
NPA28_02415	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NPA28_02420	COG2814	Major facilitator Superfamily
NPA28_02435	COG1522	sequence-specific DNA binding
NPA28_02440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NPA28_02440	COG0551	DNA topoisomerase type I activity
NPA28_02445	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NPA28_02450	COG3706	GGDEF domain
NPA28_02455	COG5298	Protein conserved in bacteria
NPA28_02460	COG1215	transferase activity, transferring glycosyl groups
NPA28_02470	COG0531	amino acid
NPA28_02475	COG0494	nUDIX hydrolase
NPA28_02480	COG0028	Belongs to the TPP enzyme family
NPA28_02490	COG1914	H( )-stimulated, divalent metal cation uptake system
NPA28_02495	COG2261	transglycosylase associated protein
NPA28_02500	COG4876	unkown
NPA28_02505	COG2217	Heavy metal translocating P-type atpase
NPA28_02510	COG3729	General stress protein
NPA28_02515	COG0662	Cupin 2, conserved barrel domain protein
NPA28_02520	COG2329	Antibiotic biosynthesis monooxygenase
NPA28_02530	COG3546	catalase activity
NPA28_02535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NPA28_02540	COG3290	protein histidine kinase activity
NPA28_02545	COG4565	transcriptional regulatory protein
NPA28_02550	COG1301	dicarboxylic acid transport
NPA28_02555	COG0628	permease
NPA28_02560	COG1301	dicarboxylic acid transport
NPA28_02565	COG1131	(ABC) transporter
NPA28_02570	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NPA28_02580	COG1960	acyl-CoA dehydrogenase activity
NPA28_02595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NPA28_02600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA28_02605	COG1181	Belongs to the D-alanine--D-alanine ligase family
NPA28_02610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NPA28_02615	COG0513	Belongs to the DEAD box helicase family
NPA28_02620	COG3402	PFAM membrane-flanked domain
NPA28_02625	COG3428	Bacterial PH domain
NPA28_02630	COG0705	Rhomboid family
NPA28_02635	COG0736	holo-[acyl-carrier-protein] synthase activity
NPA28_02640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NPA28_02645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NPA28_02650	COG0864	Transcriptional regulator
NPA28_02655	COG2337	Toxic component of a toxin-antitoxin (TA) module
NPA28_02660	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA28_02665	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA28_02670	COG2172	sigma factor antagonist activity
NPA28_02675	COG2208	phosphoserine phosphatase activity
NPA28_02680	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA28_02685	COG2172	sigma factor antagonist activity
NPA28_02690	COG1191	sigma factor activity
NPA28_02695	COG2208	phosphoserine phosphatase activity
NPA28_02700	COG2183	response to ionizing radiation
NPA28_02710	COG3091	SprT-like family
NPA28_02760	COG2072	flavoprotein involved in K transport
NPA28_02775	COG2249	NAD(P)H dehydrogenase (quinone) activity
NPA28_02790	COG1846	Transcriptional regulator
NPA28_02815	COG1476	TRANSCRIPTIONal
NPA28_02825	COG3239	Fatty acid desaturase
NPA28_02830	COG1278	Cold shock
NPA28_02835	COG1278	Cold shock
NPA28_02840	COG1329	Transcriptional regulator
NPA28_02845	COG2315	Protein conserved in bacteria
NPA28_02850	COG0346	lactoylglutathione lyase activity
NPA28_02870	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
NPA28_02880	COG2364	Membrane
NPA28_02885	COG1846	Transcriptional regulator
NPA28_02890	COG0456	acetyltransferase
NPA28_02895	COG2808	Putative FMN-binding domain
NPA28_02900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NPA28_02910	COG0693	protein deglycase activity
NPA28_02920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA28_02925	COG4257	antibiotic catabolic process
NPA28_02930	COG0456	acetyltransferase
NPA28_02940	COG2030	dehydratase
NPA28_02945	COG0697	spore germination
NPA28_02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPA28_02955	COG0596	Alpha beta hydrolase
NPA28_02960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA28_02970	COG2323	membrane
NPA28_02975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA28_02980	COG1309	transcriptional regulator
NPA28_02990	COG0456	acetyltransferase
NPA28_02995	COG0488	(ABC) transporter
NPA28_03000	COG1113	amino acid transport
NPA28_03005	COG2318	DinB family
NPA28_03010	COG1846	Transcriptional regulator
NPA28_03015	COG1033	growth of symbiont in host cell
NPA28_03015	COG2409	Drug exporters of the RND superfamily
NPA28_03025	COG0778	Nitroreductase
NPA28_03035	COG1396	sequence-specific DNA binding
NPA28_03040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NPA28_03050	COG2814	Major facilitator Superfamily
NPA28_03055	COG0730	response to heat
NPA28_03060	COG1802	Transcriptional regulator
NPA28_03065	COG3858	chitin binding
NPA28_03065	COG1388	LysM domain
NPA28_03070	COG1819	glycosyl
NPA28_03080	COG1785	Belongs to the alkaline phosphatase family
NPA28_03095	COG1078	dGTPase activity
NPA28_03100	COG1388	LysM domain
NPA28_03105	COG2814	Major facilitator Superfamily
NPA28_03110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPA28_03115	COG1447	Phosphotransferase system cellobiose-specific component IIA
NPA28_03120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPA28_03125	COG2723	6-phospho-beta-galactosidase activity
NPA28_03130	COG2188	Transcriptional regulator
NPA28_03135	COG1940	carbohydrate kinase activity
NPA28_03140	COG1482	cell wall glycoprotein biosynthetic process
NPA28_03145	COG4124	Belongs to the glycosyl hydrolase 26 family
NPA28_03190	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NPA28_03195	COG0802	atpase or kinase
NPA28_03200	COG1214	PFAM Peptidase M22, glycoprotease
NPA28_03205	COG0456	acetyltransferase
NPA28_03210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NPA28_03215	COG0488	(ABC) transporter
NPA28_03220	COG0315	cyclic pyranopterin monophosphate synthase activity
NPA28_03225	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NPA28_03230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NPA28_03235	COG0805	protein transport
NPA28_03245	COG1266	CAAX protease self-immunity
NPA28_03260	COG3409	Peptidoglycan-binding domain 1 protein
NPA28_03275	COG0457	Tetratricopeptide repeat
NPA28_03280	COG1063	alcohol dehydrogenase
NPA28_03285	COG2211	Major facilitator Superfamily
NPA28_03290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NPA28_03300	COG2814	Major facilitator Superfamily
NPA28_03305	COG1063	alcohol dehydrogenase
NPA28_03310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NPA28_03315	COG0823	Involved in the tonB-independent uptake of proteins
NPA28_03330	COG2267	carboxylic ester hydrolase activity
NPA28_03340	COG2132	Multicopper oxidase
NPA28_03345	COG1113	amino acid transport
NPA28_03350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NPA28_03355	COG0714	Associated with various cellular activities
NPA28_03360	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
NPA28_03365	COG1305	Transglutaminase-like
NPA28_03370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NPA28_03370	COG0519	Catalyzes the synthesis of GMP from XMP
NPA28_03375	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NPA28_03405	COG2252	PERMEase
NPA28_03410	COG3064	Membrane
NPA28_03420	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
NPA28_03430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NPA28_03435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NPA28_03440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NPA28_03445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NPA28_03450	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NPA28_03455	COG0047	phosphoribosylformylglycinamidine synthase activity
NPA28_03460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NPA28_03465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NPA28_03470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NPA28_03475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NPA28_03480	COG0138	bifunctional purine biosynthesis protein purh
NPA28_03485	COG0151	Belongs to the GarS family
NPA28_03490	COG1522	sequence-specific DNA binding
NPA28_03495	COG0531	amino acid
NPA28_03505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NPA28_03510	COG1470	cell adhesion involved in biofilm formation
NPA28_03515	COG4496	protein, YerC YecD
NPA28_03520	COG0069	glutamate synthase activity
NPA28_03525	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NPA28_03530	COG0210	DNA helicase
NPA28_03535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NPA28_03540	COG4851	CamS sex pheromone cAM373 precursor
NPA28_03545	COG2211	Major facilitator Superfamily
NPA28_03555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NPA28_03560	COG1285	pathogenesis
NPA28_03565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NPA28_03570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NPA28_03575	COG0154	amidase activity
NPA28_03580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NPA28_03590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NPA28_03595	COG1597	lipid kinase activity
NPA28_03600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NPA28_03605	COG0745	RESPONSE REGULATOR receiver
NPA28_03620	COG3852	Histidine kinase
NPA28_03625	COG1024	Enoyl-CoA hydratase
NPA28_03630	COG1024	Enoyl-CoA hydratase
NPA28_03635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_03640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NPA28_03650	COG3321	synthase
NPA28_03650	COG0604	alcohol dehydrogenase
NPA28_03655	COG1131	(ABC) transporter
NPA28_03670	COG3321	synthase
NPA28_03670	COG4221	oxidoreductase activity
NPA28_03670	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_03670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_03675	COG0318	PFAM AMP-dependent synthetase and ligase
NPA28_03675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_03675	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_03675	COG3321	synthase
NPA28_03675	COG0300	oxidoreductase activity
NPA28_03680	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_03680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_03680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA28_03680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_03680	COG3321	synthase
NPA28_03685	COG3321	synthase
NPA28_03685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_03685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_03685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA28_03685	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_03690	COG4221	oxidoreductase activity
NPA28_03690	COG0300	oxidoreductase activity
NPA28_03690	COG3321	synthase
NPA28_03690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_03695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_03695	COG3321	synthase
NPA28_03695	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_03695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_03695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA28_03705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_03705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_03705	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_03705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA28_03705	COG3321	synthase
NPA28_03710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_03710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_03710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA28_03710	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_03710	COG3321	synthase
NPA28_03715	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_03715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_03715	COG4221	oxidoreductase activity
NPA28_03715	COG3321	synthase
NPA28_03720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_03720	COG0300	oxidoreductase activity
NPA28_03720	COG3321	synthase
NPA28_03720	COG4221	oxidoreductase activity
NPA28_03725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NPA28_03725	COG2070	2-Nitropropane dioxygenase
NPA28_03730	COG3425	synthase
NPA28_03735	COG3586	endonuclease activity
NPA28_03740	COG3391	amine dehydrogenase activity
NPA28_03745	COG0457	Tetratricopeptide repeat
NPA28_03755	COG0217	transcriptional regulatory protein
NPA28_03765	COG1309	transcriptional regulator
NPA28_03770	COG3631	Ketosteroid isomerase-related protein
NPA28_03800	COG3546	catalase activity
NPA28_03805	COG0454	-acetyltransferase
NPA28_03815	COG5578	integral membrane protein
NPA28_03820	COG2972	Histidine kinase
NPA28_03825	COG2207	Transcriptional regulator
NPA28_03825	COG4753	response regulator
NPA28_03830	COG1653	transport
NPA28_03835	COG1175	transmembrane transport
NPA28_03840	COG0395	ABC-type sugar transport system, permease component
NPA28_03845	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NPA28_03850	COG2207	Transcriptional regulator
NPA28_03855	COG2755	lipolytic protein G-D-S-L family
NPA28_03865	COG5578	integral membrane protein
NPA28_03870	COG3401	FG-GAP repeat protein
NPA28_03875	COG3401	FG-GAP repeat protein
NPA28_03880	COG0667	Aldo Keto reductase
NPA28_03885	COG2755	lipolytic protein G-D-S-L family
NPA28_03890	COG1874	Beta-galactosidase
NPA28_03900	COG1653	transport
NPA28_03905	COG4209	transmembrane transport
NPA28_03910	COG0395	ABC-type sugar transport system, permease component
NPA28_03915	COG1486	melibiose metabolic process
NPA28_03920	COG2323	membrane
NPA28_03925	COG2329	Antibiotic biosynthesis monooxygenase
NPA28_03930	COG0346	lactoylglutathione lyase activity
NPA28_03940	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA28_03945	COG5583	Uncharacterized small protein (DUF2292)
NPA28_03950	COG0670	Belongs to the BI1 family
NPA28_03955	COG0697	spore germination
NPA28_03960	COG1846	Transcriptional regulator
NPA28_03965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NPA28_03980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NPA28_03980	COG2124	cytochrome p450
NPA28_03985	COG1368	sulfuric ester hydrolase activity
NPA28_03990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NPA28_03995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA28_04000	COG1442	glycosyl transferase family 8
NPA28_04005	COG1216	Glycosyl transferase, family 2
NPA28_04010	COG1442	glycosyl transferase family 8
NPA28_04015	COG2223	nitrite transmembrane transporter activity
NPA28_04020	COG1011	Hydrolase
NPA28_04025	COG0531	amino acid
NPA28_04030	COG1012	belongs to the aldehyde dehydrogenase family
NPA28_04035	COG0840	transmembrane signaling receptor activity
NPA28_04040	COG0488	(ABC) transporter
NPA28_04050	COG0789	Transcriptional regulator
NPA28_04055	COG2814	Major facilitator Superfamily
NPA28_04065	COG0488	(ABC) transporter
NPA28_04070	COG0513	Belongs to the DEAD box helicase family
NPA28_04075	COG0456	acetyltransferase
NPA28_04080	COG2130	NADP-dependent
NPA28_04085	COG1120	ATPase activity
NPA28_04090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA28_04095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA28_04100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NPA28_04115	COG3866	Pectate lyase
NPA28_04120	COG0471	metal ion transport
NPA28_04130	COG4565	transcriptional regulatory protein
NPA28_04135	COG3181	Tripartite tricarboxylate transporter family receptor
NPA28_04140	COG2851	Citrate transporter
NPA28_04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPA28_04150	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NPA28_04155	COG1254	Belongs to the acylphosphatase family
NPA28_04160	COG2258	MOSC domain
NPA28_04180	COG0024	Methionine aminopeptidase
NPA28_04185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA28_04185	COG1263	PTS System
NPA28_04190	COG1368	sulfuric ester hydrolase activity
NPA28_04200	COG1115	amino acid carrier protein
NPA28_04205	COG0531	amino acid
NPA28_04220	COG0697	spore germination
NPA28_04225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA28_04225	COG1263	PTS System
NPA28_04230	COG0366	Alpha amylase catalytic
NPA28_04235	COG2188	Transcriptional regulator
NPA28_04240	COG0778	Nitroreductase
NPA28_04245	COG0737	Belongs to the 5'-nucleotidase family
NPA28_04250	COG0693	protein deglycase activity
NPA28_04255	COG2814	Major facilitator Superfamily
NPA28_04260	COG4840	Belongs to the UPF0435 family
NPA28_04265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NPA28_04270	COG4980	gas vesicle protein
NPA28_04275	COG1295	ribonuclease BN
NPA28_04280	COG0477	Major facilitator Superfamily
NPA28_04285	COG0387	Pfam Sodium calcium exchanger
NPA28_04295	COG0668	transmembrane transport
NPA28_04300	COG0535	radical SAM domain protein
NPA28_04310	COG0726	polysaccharide deacetylase
NPA28_04315	COG2084	Dehydrogenase
NPA28_04320	COG0598	Magnesium transport protein CorA
NPA28_04325	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NPA28_04330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NPA28_04335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NPA28_04345	COG4637	Psort location Cytoplasmic, score
NPA28_04355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NPA28_04360	COG0022	dehydrogenase e1 component
NPA28_04365	COG0508	dehydrogenase complex catalyzes the overall conversion of
NPA28_04370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NPA28_04375	COG3284	Transcriptional regulator
NPA28_04410	COG4842	Belongs to the WXG100 family
NPA28_04415	COG1486	melibiose metabolic process
NPA28_04420	COG1737	Transcriptional regulator
NPA28_04425	COG1263	PTS System
NPA28_04425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA28_04430	COG1132	(ABC) transporter
NPA28_04435	COG1132	(ABC) transporter
NPA28_04440	COG2259	Doxx family
NPA28_04445	COG2514	catechol 2,3-dioxygenase activity
NPA28_04450	COG4585	Histidine kinase
NPA28_04455	COG2197	response regulator
NPA28_04460	COG1131	(ABC) transporter
NPA28_04465	COG0842	Transport permease protein
NPA28_04465	COG1511	domain protein
NPA28_04470	COG0842	Transport permease protein
NPA28_04480	COG1695	Transcriptional regulator
NPA28_04485	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NPA28_04490	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
NPA28_04495	COG2318	DinB family
NPA28_04500	COG2814	Major facilitator Superfamily
NPA28_04505	COG1846	Transcriptional regulator
NPA28_04510	COG0392	lysyltransferase activity
NPA28_04510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NPA28_04515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA28_04520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA28_04525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA28_04530	COG0384	phenazine biosynthesis protein PhzF
NPA28_04535	COG0778	Nitroreductase
NPA28_04550	COG1090	epimerase
NPA28_04555	COG2137	regulation of response to DNA damage stimulus
NPA28_04565	COG2814	Major facilitator Superfamily
NPA28_04585	COG1476	TRANSCRIPTIONal
NPA28_04590	COG3103	Sh3 type 3 domain protein
NPA28_04595	COG5658	integral membrane protein
NPA28_04600	COG0596	Alpha beta hydrolase
NPA28_04605	COG0463	Glycosyl transferase, family 2
NPA28_04610	COG4485	Bacterial membrane protein, YfhO
NPA28_04615	COG1988	membrane-bound metal-dependent
NPA28_04620	COG1194	a g-specific adenine glycosylase
NPA28_04630	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_04645	COG3557	Belongs to the UPF0374 family
NPA28_04650	COG1132	(ABC) transporter
NPA28_04655	COG4129	membrane
NPA28_04660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NPA28_04665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NPA28_04670	COG0735	belongs to the Fur family
NPA28_04780	COG4326	sporulation control protein
NPA28_04790	COG1063	alcohol dehydrogenase
NPA28_04795	COG5577	PFAM Coat F domain
NPA28_04810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NPA28_04820	COG0753	catalase activity
NPA28_04825	COG1116	anion transmembrane transporter activity
NPA28_04830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NPA28_04835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NPA28_04840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NPA28_04850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NPA28_04860	COG1476	TRANSCRIPTIONal
NPA28_04870	COG3382	B3 4 domain protein
NPA28_04875	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NPA28_04885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NPA28_04890	COG0789	Transcriptional regulator
NPA28_04895	COG1664	Polymer-forming cytoskeletal
NPA28_04900	COG1664	Polymer-forming cytoskeletal
NPA28_04905	COG2766	serine protein kinase
NPA28_04910	COG2718	Belongs to the UPF0229 family
NPA28_04915	COG1846	Transcriptional regulator
NPA28_04925	COG2814	Major facilitator Superfamily
NPA28_04930	COG0655	NAD(P)H dehydrogenase (quinone) activity
NPA28_04945	COG1725	Transcriptional regulator
NPA28_04950	COG1131	(ABC) transporter
NPA28_04955	COG1131	(ABC) transporter
NPA28_04960	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NPA28_04965	COG1278	Cold shock
NPA28_04970	COG1464	Belongs to the NlpA lipoprotein family
NPA28_04975	COG3706	GGDEF domain
NPA28_04980	COG1823	symporter activity
NPA28_04985	COG5444	nuclease activity
NPA28_05025	COG5577	PFAM Coat F domain
NPA28_05030	COG0737	Belongs to the 5'-nucleotidase family
NPA28_05030	COG4085	toxin activity
NPA28_05030	COG1525	nuclease
NPA28_05035	COG3764	Sortase (surface protein transpeptidase)
NPA28_05040	COG0564	pseudouridine synthase activity
NPA28_05050	COG0517	IMP dehydrogenase activity
NPA28_05055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NPA28_05060	COG3153	acetyltransferase
NPA28_05060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NPA28_05070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NPA28_05075	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NPA28_05080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NPA28_05085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NPA28_05090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NPA28_05095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NPA28_05100	COG4585	Histidine kinase
NPA28_05100	COG2203	Gaf domain
NPA28_05105	COG2197	response regulator
NPA28_05110	COG0431	NADPH-dependent FMN reductase
NPA28_05125	COG0791	NLP P60 protein
NPA28_05125	COG1388	LysM domain
NPA28_05130	COG1959	2 iron, 2 sulfur cluster binding
NPA28_05140	COG2719	SpoVR family
NPA28_05150	COG1785	Belongs to the alkaline phosphatase family
NPA28_05155	COG1388	LysM domain
NPA28_05155	COG0791	NLP P60 protein
NPA28_05160	COG0583	DNA-binding transcription factor activity
NPA28_05165	COG0372	Belongs to the citrate synthase family
NPA28_05170	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_05175	COG0531	amino acid
NPA28_05180	COG0733	neurotransmitter:sodium symporter activity
NPA28_05185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPA28_05190	COG0456	acetyltransferase
NPA28_05205	COG1595	DNA-templated transcription, initiation
NPA28_05210	COG0667	Aldo Keto reductase
NPA28_05215	COG0204	Acyl-transferase
NPA28_05220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NPA28_05225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA28_05230	COG1253	flavin adenine dinucleotide binding
NPA28_05235	COG0789	Transcriptional regulator
NPA28_05240	COG0436	Aminotransferase
NPA28_05245	COG1253	flavin adenine dinucleotide binding
NPA28_05250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NPA28_05255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NPA28_05260	COG0584	glycerophosphoryl diester phosphodiesterase
NPA28_05270	COG0668	transmembrane transport
NPA28_05275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NPA28_05280	COG0726	polysaccharide deacetylase
NPA28_05285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NPA28_05290	COG1757	Na H antiporter
NPA28_05295	COG0589	response to stress
NPA28_05300	COG1132	(ABC) transporter
NPA28_05305	COG1132	(ABC) transporter
NPA28_05310	COG0702	epimerase
NPA28_05330	COG0189	ligase activity
NPA28_05335	COG0189	ligase activity
NPA28_05340	COG4399	Belongs to the UPF0754 family
NPA28_05345	COG3679	Belongs to the UPF0342 family
NPA28_05350	COG4335	DNA alkylation repair
NPA28_05355	COG0561	phosphatase activity
NPA28_05360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NPA28_05365	COG0475	glutathione-regulated potassium exporter activity
NPA28_05370	COG0490	domain, Protein
NPA28_05380	COG1024	Enoyl-CoA hydratase
NPA28_05390	COG4152	abc transporter atp-binding protein
NPA28_05395	COG1668	transmembrane transport
NPA28_05400	COG0420	3'-5' exonuclease activity
NPA28_05405	COG4717	serine-type aminopeptidase activity
NPA28_05410	COG3481	metal-dependent phosphohydrolase, HD sub domain
NPA28_05420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NPA28_05450	COG1846	Transcriptional regulator
NPA28_05455	COG4980	gas vesicle protein
NPA28_05470	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NPA28_05475	COG0537	adenosine 5'-monophosphoramidase activity
NPA28_05480	COG1131	(ABC) transporter
NPA28_05485	COG4473	ABC transporter
NPA28_05495	COG1473	amidohydrolase
NPA28_05500	COG3069	C4-dicarboxylate transmembrane transporter activity
NPA28_05505	COG2329	Antibiotic biosynthesis monooxygenase
NPA28_05510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NPA28_05515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NPA28_05520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NPA28_05525	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NPA28_05530	COG1309	transcriptional regulator
NPA28_05535	COG1511	domain protein
NPA28_05540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NPA28_05545	COG4377	Putative membrane peptidase family (DUF2324)
NPA28_05555	COG1363	Peptidase, m42
NPA28_05560	COG4405	Protein conserved in bacteria
NPA28_05565	COG1301	dicarboxylic acid transport
NPA28_05575	COG1234	tRNA 3'-trailer cleavage
NPA28_05580	COG0095	Lipoate-protein ligase
NPA28_05585	COG0702	epimerase
NPA28_05590	COG0318	PFAM AMP-dependent synthetase and ligase
NPA28_05600	COG0501	Belongs to the peptidase M48B family
NPA28_05605	COG1404	Belongs to the peptidase S8 family
NPA28_05610	COG0456	acetyltransferase
NPA28_05615	COG0604	alcohol dehydrogenase
NPA28_05620	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NPA28_05625	COG0406	alpha-ribazole phosphatase activity
NPA28_05630	COG0183	Belongs to the thiolase family
NPA28_05635	COG0318	PFAM AMP-dependent synthetase and ligase
NPA28_05640	COG1268	BioY protein
NPA28_05645	COG0840	transmembrane signaling receptor activity
NPA28_05650	COG0723	plastoquinol--plastocyanin reductase activity
NPA28_05650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NPA28_05655	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_05665	COG4903	ComK protein
NPA28_05670	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_05680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NPA28_05695	COG0398	Pfam SNARE associated Golgi protein
NPA28_05700	COG0681	Belongs to the peptidase S26 family
NPA28_05705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NPA28_05710	COG1846	Transcriptional regulator
NPA28_05720	COG0738	Major facilitator superfamily
NPA28_05725	COG0673	inositol 2-dehydrogenase activity
NPA28_05730	COG0561	phosphatase activity
NPA28_05735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NPA28_05740	COG1609	Transcriptional regulator
NPA28_05745	COG3180	Ammonia monooxygenase
NPA28_05755	COG4533	DNA binding
NPA28_05765	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NPA28_05770	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NPA28_05775	COG1074	ATP-dependent DNA helicase activity
NPA28_05780	COG0420	3'-5' exonuclease activity
NPA28_05785	COG0419	ATPase involved in DNA repair
NPA28_05790	COG1403	HNH endonuclease
NPA28_05830	COG5337	Spore coat protein CotH
NPA28_05835	COG0179	Fumarylacetoacetate (FAA) hydrolase
NPA28_05845	COG1404	Belongs to the peptidase S8 family
NPA28_05855	COG0367	asparagine synthase
NPA28_05860	COG2318	DinB family
NPA28_05870	COG0534	Mate efflux family protein
NPA28_05875	COG1917	Cupin 2, conserved barrel domain protein
NPA28_05875	COG2207	Transcriptional regulator
NPA28_05880	COG1609	Transcriptional regulator
NPA28_05885	COG0673	inositol 2-dehydrogenase activity
NPA28_05890	COG2318	DinB family
NPA28_05895	COG1279	arginine transmembrane transporter activity
NPA28_05900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPA28_05905	COG1357	PFAM Pentapeptide repeats (8 copies)
NPA28_05910	COG2267	carboxylic ester hydrolase activity
NPA28_05915	COG0529	Catalyzes the synthesis of activated sulfate
NPA28_05920	COG2046	Belongs to the sulfate adenylyltransferase family
NPA28_05925	COG0175	sulfate reduction
NPA28_05930	COG2045	Belongs to the ComB family
NPA28_05935	COG1809	phosphosulfolactate synthase activity
NPA28_05940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA28_05945	COG4948	Mandelate Racemase Muconate Lactonizing
NPA28_05950	COG2814	Major facilitator Superfamily
NPA28_05960	COG2153	protein acetylation
NPA28_05965	COG0646	methionine synthase
NPA28_05965	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NPA28_05970	COG1666	GTP binding
NPA28_05975	COG2996	Protein conserved in bacteria
NPA28_05995	COG1695	Transcriptional regulator
NPA28_06010	COG3227	Zinc metalloprotease (Elastase)
NPA28_06015	COG1307	EDD domain protein, DegV family
NPA28_06020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA28_06040	COG0561	phosphatase activity
NPA28_06045	COG1073	alpha beta
NPA28_06050	COG2151	metal-sulfur cluster biosynthetic enzyme
NPA28_06060	COG0277	FAD linked oxidase domain protein
NPA28_06065	COG2271	Major facilitator Superfamily
NPA28_06070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NPA28_06075	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NPA28_06085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NPA28_06090	COG0505	Belongs to the CarA family
NPA28_06095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NPA28_06100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NPA28_06115	COG2267	carboxylic ester hydrolase activity
NPA28_06125	COG1744	ABC transporter substrate-binding protein PnrA-like
NPA28_06140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NPA28_06145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NPA28_06150	COG5504	Zn-dependent protease
NPA28_06155	COG0444	Belongs to the ABC transporter superfamily
NPA28_06160	COG4608	Belongs to the ABC transporter superfamily
NPA28_06170	COG0601	transmembrane transport
NPA28_06175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NPA28_06185	COG0180	Tryptophanyl-tRNA synthetase
NPA28_06190	COG4166	transmembrane transport
NPA28_06195	COG0601	transmembrane transport
NPA28_06200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NPA28_06205	COG0444	Belongs to the ABC transporter superfamily
NPA28_06210	COG4608	Belongs to the ABC transporter superfamily
NPA28_06215	COG2814	Major facilitator Superfamily
NPA28_06220	COG0456	acetyltransferase
NPA28_06225	COG1393	Belongs to the ArsC family
NPA28_06230	COG0861	Integral membrane protein TerC family
NPA28_06240	COG4862	establishment of competence for transformation
NPA28_06245	COG4469	Competence protein
NPA28_06250	COG1164	Oligoendopeptidase f
NPA28_06260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NPA28_06265	COG2346	COG2346, Truncated hemoglobins
NPA28_06270	COG0741	lytic transglycosylase activity
NPA28_06275	COG4116	CYTH
NPA28_06285	COG2357	RelA SpoT domain protein
NPA28_06290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NPA28_06295	COG0564	pseudouridine synthase activity
NPA28_06300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NPA28_06305	COG0569	domain protein
NPA28_06305	COG0475	glutathione-regulated potassium exporter activity
NPA28_06310	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NPA28_06315	COG0352	thiamine-phosphate diphosphorylase activity
NPA28_06320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NPA28_06325	COG2104	thiamine diphosphate biosynthetic process
NPA28_06330	COG2022	thiamine diphosphate biosynthetic process
NPA28_06335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NPA28_06340	COG0351	phosphomethylpyrimidine kinase
NPA28_06345	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NPA28_06400	COG0210	DNA helicase
NPA28_06410	COG2153	protein acetylation
NPA28_06415	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NPA28_06420	COG2382	esterase
NPA28_06425	COG0626	cystathionine gamma-synthase activity
NPA28_06430	COG0626	cystathionine gamma-synthase activity
NPA28_06435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA28_06440	COG5505	Protein of unknown function (DUF819)
NPA28_06450	COG4974	Belongs to the 'phage' integrase family
NPA28_06455	COG2856	Zn peptidase
NPA28_06465	COG1396	sequence-specific DNA binding
NPA28_06480	COG3646	Phage regulatory protein
NPA28_06480	COG3645	SOS response
NPA28_06515	COG3935	DnaD domain protein
NPA28_06520	COG1484	DNA-dependent DNA replication
NPA28_06530	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
NPA28_06565	COG1595	DNA-templated transcription, initiation
NPA28_06590	COG5484	DNA packaging
NPA28_06660	COG3953	SLT domain
NPA28_06660	COG5280	Phage tail tape measure protein TP901
NPA28_06665	COG1388	LysM domain
NPA28_06665	COG0791	NLP P60 protein
NPA28_06720	COG4824	toxin secretion phage lysis holin
NPA28_06725	COG5632	N-Acetylmuramoyl-L-alanine amidase
NPA28_06725	COG3409	Peptidoglycan-binding domain 1 protein
NPA28_06735	COG5444	nuclease activity
NPA28_06755	COG0457	Tetratricopeptide repeat
NPA28_06790	COG3409	Peptidoglycan-binding domain 1 protein
NPA28_06810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA28_06820	COG0789	Transcriptional regulator
NPA28_06835	COG0109	protoheme IX farnesyltransferase activity
NPA28_06845	COG0726	polysaccharide deacetylase
NPA28_06860	COG5504	Zn-dependent protease
NPA28_06865	COG2205	protein histidine kinase activity
NPA28_06875	COG3383	formate dehydrogenase (NAD+) activity
NPA28_06880	COG2427	Protein of unknown function (DUF1641)
NPA28_06890	COG1051	belongs to the nudix hydrolase family
NPA28_06900	COG2124	cytochrome p450
NPA28_06905	COG1819	glycosyl
NPA28_06920	COG1587	Uroporphyrinogen-III synthase
NPA28_06925	COG0390	transport system, permease component
NPA28_06930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NPA28_06935	COG0697	spore germination
NPA28_06940	COG4297	protein containing double-stranded beta helix domain
NPA28_06950	COG1252	NADH dehydrogenase
NPA28_06955	COG1904	glucuronate isomerase
NPA28_06960	COG2211	Major facilitator Superfamily
NPA28_06965	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NPA28_06970	COG1063	alcohol dehydrogenase
NPA28_06975	COG1312	Catalyzes the dehydration of D-mannonate
NPA28_06980	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_06985	COG2271	Major facilitator Superfamily
NPA28_06990	COG1609	Transcriptional regulator
NPA28_06995	COG0246	Mannitol dehydrogenase
NPA28_07000	COG2721	sulfolactate sulfo-lyase activity
NPA28_07005	COG0730	response to heat
NPA28_07010	COG2318	DinB family
NPA28_07015	COG0457	Tetratricopeptide repeat
NPA28_07025	COG2350	Protein conserved in bacteria
NPA28_07030	COG5632	N-Acetylmuramoyl-L-alanine amidase
NPA28_07030	COG1388	LysM domain
NPA28_07030	COG3409	Peptidoglycan-binding domain 1 protein
NPA28_07040	COG4195	phage-related replication protein
NPA28_07045	COG3546	catalase activity
NPA28_07050	COG2856	Zn peptidase
NPA28_07055	COG1396	sequence-specific DNA binding
NPA28_07065	COG1522	sequence-specific DNA binding
NPA28_07070	COG1484	DNA-dependent DNA replication
NPA28_07090	COG1595	DNA-templated transcription, initiation
NPA28_07095	COG3728	DNA packaging
NPA28_07095	COG5484	DNA packaging
NPA28_07100	COG1783	phage Terminase large subunit
NPA28_07105	COG5518	Phage portal protein
NPA28_07110	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NPA28_07165	COG3953	SLT domain
NPA28_07165	COG5412	phage tail tape measure protein
NPA28_07170	COG1652	LysM domain
NPA28_07175	COG4193	domain, Protein
NPA28_07185	COG3628	GPW Gp25 family protein
NPA28_07190	COG3299	homolog of phage Mu protein gp47
NPA28_07195	COG3778	Protein conserved in bacteria
NPA28_07240	COG3409	Peptidoglycan-binding domain 1 protein
NPA28_07240	COG5632	N-Acetylmuramoyl-L-alanine amidase
NPA28_07260	COG0306	phosphate transporter
NPA28_07265	COG1392	Phosphate transport regulator
NPA28_07270	COG0531	amino acid
NPA28_07275	COG0346	lactoylglutathione lyase activity
NPA28_07285	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NPA28_07290	COG0463	Glycosyl transferase, family 2
NPA28_07300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NPA28_07305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NPA28_07310	COG2362	D-Aminopeptidase
NPA28_07315	COG0601	transmembrane transport
NPA28_07320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NPA28_07325	COG0444	Belongs to the ABC transporter superfamily
NPA28_07330	COG4166	transmembrane transport
NPA28_07335	COG1619	proteins homologs of microcin C7 resistance protein MccF
NPA28_07340	COG4948	Mandelate Racemase Muconate Lactonizing
NPA28_07345	COG0791	NLP P60 protein
NPA28_07350	COG4608	Belongs to the ABC transporter superfamily
NPA28_07355	COG2706	6-phosphogluconolactonase activity
NPA28_07360	COG1834	amidinotransferase
NPA28_07365	COG1607	acyl-coa hydrolase
NPA28_07370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NPA28_07370	COG1017	nitric oxide dioxygenase activity
NPA28_07380	COG2323	membrane
NPA28_07385	COG2318	DinB family
NPA28_07390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA28_07395	COG2076	Multidrug Resistance protein
NPA28_07400	COG2076	Multidrug Resistance protein
NPA28_07405	COG0788	formyltetrahydrofolate deformylase activity
NPA28_07410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NPA28_07415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NPA28_07420	COG1764	response to oxidative stress
NPA28_07425	COG1846	Transcriptional regulator
NPA28_07430	COG1764	response to oxidative stress
NPA28_07435	COG0457	Tetratricopeptide repeat
NPA28_07435	COG0463	Glycosyl transferase, family 2
NPA28_07445	COG0590	tRNA wobble adenosine to inosine editing
NPA28_07450	COG0406	alpha-ribazole phosphatase activity
NPA28_07455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NPA28_07460	COG1404	Belongs to the peptidase S8 family
NPA28_07465	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA28_07470	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NPA28_07480	COG4721	ABC-type cobalt transport system, permease component
NPA28_07490	COG0745	RESPONSE REGULATOR receiver
NPA28_07495	COG3850	Histidine kinase
NPA28_07495	COG5002	protein histidine kinase activity
NPA28_07500	COG3212	peptidase
NPA28_07505	COG3212	peptidase
NPA28_07520	COG2239	Acts as a magnesium transporter
NPA28_07525	COG0789	Transcriptional regulator
NPA28_07540	COG1846	Transcriptional regulator
NPA28_07545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NPA28_07550	COG0726	polysaccharide deacetylase
NPA28_07555	COG1408	metallophosphoesterase
NPA28_07565	COG0463	Glycosyl transferase, family 2
NPA28_07570	COG1793	dna ligase
NPA28_07570	COG3285	dna ligase
NPA28_07575	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NPA28_07580	COG5001	Diguanylate cyclase
NPA28_07580	COG3300	MHYT domain
NPA28_07585	COG0586	Pfam SNARE associated Golgi protein
NPA28_07595	COG1191	sigma factor activity
NPA28_07615	COG0501	Belongs to the peptidase M48B family
NPA28_07620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NPA28_07635	COG3594	Acyltransferase
NPA28_07640	COG5002	protein histidine kinase activity
NPA28_07645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NPA28_07655	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NPA28_07660	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NPA28_07665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NPA28_07670	COG0436	Aminotransferase
NPA28_07675	COG1850	ribulose-bisphosphate carboxylase activity
NPA28_07680	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
NPA28_07685	COG0235	Class ii aldolase
NPA28_07690	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NPA28_07695	COG3339	Conserved Protein
NPA28_07710	COG3852	Histidine kinase
NPA28_07715	COG1846	Transcriptional regulator
NPA28_07720	COG1360	Flagellar Motor Protein
NPA28_07725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NPA28_07730	COG0542	response to heat
NPA28_07735	COG3949	Membrane
NPA28_07740	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NPA28_07745	COG0720	synthase
NPA28_07750	COG0602	queuosine metabolic process
NPA28_07755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NPA28_07760	COG1388	LysM domain
NPA28_07760	COG4641	Protein conserved in bacteria
NPA28_07765	COG1388	LysM domain
NPA28_07770	COG3858	chitin binding
NPA28_07780	COG4873	Protein conserved in bacteria
NPA28_07790	COG3773	Cell wall hydrolase
NPA28_07795	COG2244	polysaccharide biosynthetic process
NPA28_07800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA28_07805	COG2217	Heavy metal translocating P-type atpase
NPA28_07815	COG0006	proline dipeptidase activity
NPA28_07825	COG1609	Transcriptional regulator
NPA28_07830	COG3711	transcriptional antiterminator
NPA28_07835	COG2190	(PTS) system
NPA28_07835	COG1263	PTS System
NPA28_07835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA28_07840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA28_07845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NPA28_07855	COG1533	DNA photolyase activity
NPA28_07860	COG0456	acetyltransferase
NPA28_07865	COG0840	transmembrane signaling receptor activity
NPA28_07870	COG2084	Dehydrogenase
NPA28_07875	COG2340	Cysteine-rich secretory protein family
NPA28_07880	COG0768	penicillin binding
NPA28_07885	COG4191	Histidine kinase
NPA28_07890	COG0436	Aminotransferase
NPA28_07900	COG0835	chemotaxis
NPA28_07900	COG0784	Response regulator, receiver
NPA28_07910	COG2814	Major facilitator Superfamily
NPA28_07915	COG1376	ErfK ybiS ycfS ynhG family protein
NPA28_07920	COG1408	metallophosphoesterase
NPA28_07925	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_07930	COG2200	EAL domain
NPA28_07935	COG3546	catalase activity
NPA28_07940	COG4703	Protein of unknown function (DUF1797)
NPA28_07945	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NPA28_07955	COG0517	IMP dehydrogenase activity
NPA28_07960	COG0583	DNA-binding transcription factor activity
NPA28_07965	COG0716	FMN binding
NPA28_07975	COG0716	FMN binding
NPA28_07980	COG2171	N-acyltransferase activity
NPA28_07985	COG1473	amidohydrolase
NPA28_07995	COG0668	transmembrane transport
NPA28_08000	COG0450	alkyl hydroperoxide reductase
NPA28_08005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA28_08020	COG0746	molybdenum cofactor guanylyltransferase activity
NPA28_08025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NPA28_08030	COG0303	'Molybdopterin
NPA28_08035	COG1763	Mo-molybdopterin cofactor biosynthetic process
NPA28_08040	COG0314	molybdopterin synthase activity
NPA28_08045	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NPA28_08050	COG1132	(ABC) transporter
NPA28_08055	COG1132	(ABC) transporter
NPA28_08065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NPA28_08070	COG1136	(ABC) transporter
NPA28_08075	COG0577	efflux transmembrane transporter activity
NPA28_08080	COG1349	DNA-binding transcription factor activity
NPA28_08085	COG1105	Belongs to the carbohydrate kinase PfkB family
NPA28_08090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPA28_08090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA28_08090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPA28_08095	COG0681	Belongs to the peptidase S26 family
NPA28_08105	COG0488	(ABC) transporter
NPA28_08110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NPA28_08115	COG2309	aminopeptidase activity
NPA28_08125	COG1077	Cell shape determining protein MreB Mrl
NPA28_08130	COG2002	toxin-antitoxin pair type II binding
NPA28_08135	COG3852	Histidine kinase
NPA28_08140	COG2105	PFAM AIG2 family protein
NPA28_08140	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NPA28_08145	COG0569	domain protein
NPA28_08150	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NPA28_08155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NPA28_08160	COG5503	Protein of unknown function (DUF1447)
NPA28_08165	COG0561	phosphatase activity
NPA28_08170	COG0242	peptide deformylase activity
NPA28_08180	COG0497	DNA recombination
NPA28_08185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NPA28_08190	COG0022	dehydrogenase e1 component
NPA28_08195	COG0508	dehydrogenase complex catalyzes the overall conversion of
NPA28_08200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NPA28_08205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA28_08215	COG1982	Orn Lys Arg decarboxylase major
NPA28_08220	COG4476	Belongs to the UPF0223 family
NPA28_08225	COG4493	Belongs to the UPF0637 family
NPA28_08235	COG0483	inositol monophosphate 1-phosphatase activity
NPA28_08245	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NPA28_08275	COG1217	gtp-binding protein TYPA
NPA28_08285	COG4896	Protein conserved in bacteria
NPA28_08295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NPA28_08300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NPA28_08305	COG2066	Belongs to the glutaminase family
NPA28_08310	COG4838	Belongs to the UPF0358 family
NPA28_08315	COG0772	Belongs to the SEDS family
NPA28_08320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NPA28_08325	COG1612	heme a metabolic process
NPA28_08330	COG0109	protoheme IX farnesyltransferase activity
NPA28_08335	COG2010	Cytochrome c
NPA28_08335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NPA28_08340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NPA28_08345	COG1845	cytochrome c oxidase, subunit III
NPA28_08350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NPA28_08355	COG3336	cytochrome c oxidase
NPA28_08365	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NPA28_08370	COG2340	Cysteine-rich secretory protein family
NPA28_08385	COG3679	Belongs to the UPF0342 family
NPA28_08390	COG4471	UPF0298 protein
NPA28_08395	COG0742	ribosomal rna small subunit methyltransferase
NPA28_08400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NPA28_08405	COG3314	Sporulation integral membrane protein YlbJ
NPA28_08410	COG1752	Esterase of the alpha-beta hydrolase superfamily
NPA28_08415	COG3480	Lon protease (S16) C-terminal proteolytic domain
NPA28_08420	COG1323	Belongs to the UPF0348 family
NPA28_08430	COG1399	metal-binding, possibly nucleic acid-binding protein
NPA28_08445	COG0454	-acetyltransferase
NPA28_08450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NPA28_08455	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NPA28_08460	COG2001	Belongs to the MraZ family
NPA28_08465	COG0275	rRNA processing
NPA28_08470	COG4839	cell division protein FtsL
NPA28_08475	COG0768	penicillin binding
NPA28_08480	COG0768	penicillin binding
NPA28_08485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NPA28_08490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NPA28_08495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NPA28_08500	COG0772	Belongs to the SEDS family
NPA28_08505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NPA28_08510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NPA28_08515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NPA28_08520	COG3879	Bacterial protein of unknown function (DUF881)
NPA28_08525	COG3879	Bacterial protein of unknown function (DUF881)
NPA28_08530	COG3856	small basic protein
NPA28_08535	COG0849	cell division
NPA28_08540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NPA28_08545	COG4412	M6 family metalloprotease domain protein
NPA28_08545	COG1404	Belongs to the peptidase S8 family
NPA28_08555	COG1191	sigma factor activity
NPA28_08560	COG1191	sigma factor activity
NPA28_08565	COG1119	ATPase activity
NPA28_08570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NPA28_08575	COG1873	PFAM PRC-barrel domain
NPA28_08580	COG1496	oxidoreductase activity
NPA28_08585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NPA28_08590	COG1799	cell septum assembly
NPA28_08595	COG0762	integral membrane protein
NPA28_08600	COG2302	S4 RNA-binding domain
NPA28_08605	COG3599	regulation of cell shape
NPA28_08610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NPA28_08615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NPA28_08620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NPA28_08625	COG0564	pseudouridine synthase activity
NPA28_08630	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NPA28_08635	COG2233	PERMEase
NPA28_08640	COG0540	Belongs to the ATCase OTCase family
NPA28_08645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NPA28_08650	COG0505	Belongs to the CarA family
NPA28_08655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NPA28_08660	COG0543	2 iron, 2 sulfur cluster binding
NPA28_08665	COG0167	dihydroorotate dehydrogenase activity
NPA28_08670	COG0284	orotidine-5'-phosphate decarboxylase activity
NPA28_08675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NPA28_08680	COG0175	sulfate reduction
NPA28_08685	COG0306	phosphate transporter
NPA28_08690	COG2046	Belongs to the sulfate adenylyltransferase family
NPA28_08695	COG0529	Catalyzes the synthesis of activated sulfate
NPA28_08700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NPA28_08705	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NPA28_08710	COG1648	precorrin-2 dehydrogenase activity
NPA28_08715	COG1293	RNA-binding protein homologous to eukaryotic snRNP
NPA28_08720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NPA28_08725	COG1561	YicC-like family, N-terminal region
NPA28_08735	COG0194	GDP metabolic process
NPA28_08740	COG1758	RNA polymerase activity
NPA28_08745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NPA28_08750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NPA28_08755	COG0242	peptide deformylase activity
NPA28_08760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NPA28_08765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NPA28_08765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NPA28_08770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NPA28_08775	COG0631	protein serine/threonine phosphatase activity
NPA28_08780	COG2815	serine threonine protein kinase
NPA28_08780	COG0515	serine threonine protein kinase
NPA28_08785	COG1162	GTPase activity
NPA28_08790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NPA28_08795	COG1564	THIamine pyrophosphokinase
NPA28_08805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NPA28_08810	COG1302	Protein conserved in bacteria
NPA28_08815	COG1461	Dihydroxyacetone kinase
NPA28_08820	COG1760	l-serine dehydratase
NPA28_08825	COG1760	l-serine dehydratase
NPA28_08830	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NPA28_08835	COG2050	protein possibly involved in aromatic compounds catabolism
NPA28_08835	COG1349	DNA-binding transcription factor activity
NPA28_08840	COG0416	fatty acid biosynthetic process
NPA28_08845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NPA28_08850	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_08860	COG0571	ribonuclease III activity
NPA28_08865	COG1196	nuclear chromosome segregation
NPA28_08870	COG0552	protein localization to endoplasmic reticulum
NPA28_08880	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NPA28_08885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NPA28_08890	COG0228	four-way junction DNA binding
NPA28_08895	COG1837	Belongs to the UPF0109 family
NPA28_08905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NPA28_08910	COG0336	Belongs to the RNA methyltransferase TrmD family
NPA28_08915	COG0335	large ribosomal subunit rRNA binding
NPA28_08920	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NPA28_08925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NPA28_08935	COG2257	FlhB HrpN YscU SpaS Family
NPA28_08940	COG0045	succinate-CoA ligase (ADP-forming) activity
NPA28_08945	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NPA28_08950	COG0758	DNA mediated transformation
NPA28_08955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NPA28_08960	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NPA28_08965	COG4974	Belongs to the 'phage' integrase family
NPA28_08970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NPA28_08975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NPA28_08980	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NPA28_08985	COG1815	bacterial-type flagellum-dependent cell motility
NPA28_08990	COG1558	bacterial-type flagellum-dependent cell motility
NPA28_08995	COG1677	Flagellar hook-basal body complex protein FliE
NPA28_09000	COG1766	The M ring may be actively involved in energy transduction
NPA28_09005	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NPA28_09010	COG1317	bacterial-type flagellum organization
NPA28_09015	COG1157	protein secretion by the type III secretion system
NPA28_09020	COG2882	bacterial-type flagellum organization
NPA28_09025	COG3334	PFAM MgtE intracellular
NPA28_09030	COG3144	bacterial-type flagellum assembly
NPA28_09035	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NPA28_09040	COG4786	Flagellar basal body rod
NPA28_09045	COG1582	Flagellar protein (FlbD)
NPA28_09050	COG1580	Controls the rotational direction of flagella during chemotaxis
NPA28_09055	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NPA28_09060	COG1776	CheC inhibitor of MCP methylation
NPA28_09060	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NPA28_09065	COG2201	protein-glutamate methylesterase activity
NPA28_09070	COG3190	flagellar
NPA28_09075	COG1338	Plays a role in the flagellum-specific transport system
NPA28_09080	COG1987	bacterial-type flagellum assembly
NPA28_09085	COG1684	flagellar biosynthetic protein fliR
NPA28_09090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NPA28_09095	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NPA28_09100	COG1419	protein localization to endoplasmic reticulum
NPA28_09105	COG0455	bacterial-type flagellum organization
NPA28_09110	COG2201	protein-glutamate methylesterase activity
NPA28_09115	COG0643	Histidine kinase
NPA28_09115	COG2198	Histidine kinase
NPA28_09120	COG0835	chemotaxis
NPA28_09125	COG1776	CheC inhibitor of MCP methylation
NPA28_09130	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NPA28_09135	COG1191	sigma factor activity
NPA28_09145	COG0052	Belongs to the universal ribosomal protein uS2 family
NPA28_09150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NPA28_09155	COG0528	UMP kinase activity
NPA28_09160	COG0233	cytoplasmic translational termination
NPA28_09165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NPA28_09170	COG4589	Belongs to the CDS family
NPA28_09175	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NPA28_09180	COG0750	zinc metalloprotease
NPA28_09185	COG0442	prolyl-tRNA aminoacylation
NPA28_09190	COG2176	DNA-directed DNA polymerase activity
NPA28_09195	COG0779	Required for maturation of 30S ribosomal subunits
NPA28_09200	COG0195	Participates in both transcription termination and antitermination
NPA28_09205	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NPA28_09210	COG1358	cellular component organization or biogenesis
NPA28_09215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NPA28_09220	COG1550	Protein conserved in bacteria
NPA28_09225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NPA28_09230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NPA28_09235	COG0196	riboflavin kinase activity
NPA28_09245	COG1185	polyribonucleotide nucleotidyltransferase activity
NPA28_09250	COG0726	polysaccharide deacetylase
NPA28_09255	COG0612	Peptidase, M16
NPA28_09260	COG1873	PFAM PRC-barrel domain
NPA28_09265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NPA28_09270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NPA28_09275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NPA28_09280	COG0527	aspartate kinase activity
NPA28_09285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NPA28_09290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NPA28_09295	COG0740	serine-type endopeptidase activity
NPA28_09305	COG4980	gas vesicle protein
NPA28_09305	COG1674	ftsk spoiiie
NPA28_09310	COG2188	Transcriptional regulator
NPA28_09315	COG2814	Major facilitator Superfamily
NPA28_09320	COG0612	Peptidase, M16
NPA28_09325	COG0612	Peptidase, M16
NPA28_09330	COG0300	oxidoreductase activity
NPA28_09345	COG1426	Protein conserved in bacteria
NPA28_09350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NPA28_09355	COG1546	Belongs to the CinA family
NPA28_09355	COG1058	Belongs to the CinA family
NPA28_09360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NPA28_09365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NPA28_09370	COG1418	mRNA catabolic process
NPA28_09375	COG1692	metallophosphoesterase
NPA28_09380	COG2359	stage V sporulation protein S
NPA28_09385	COG1063	alcohol dehydrogenase
NPA28_09390	COG0156	8-amino-7-oxononanoate synthase activity
NPA28_09395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NPA28_09400	COG4550	Control of competence regulator ComK, YlbF/YmcA
NPA28_09410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NPA28_09415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NPA28_09470	COG3226	Transcriptional regulator
NPA28_09475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPA28_09480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NPA28_09485	COG3321	synthase
NPA28_09490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NPA28_09490	COG2070	2-Nitropropane dioxygenase
NPA28_09495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_09500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NPA28_09505	COG3425	synthase
NPA28_09510	COG1024	Enoyl-CoA hydratase
NPA28_09515	COG1024	Enoyl-CoA hydratase
NPA28_09520	COG3321	synthase
NPA28_09520	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_09520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_09520	COG0318	PFAM AMP-dependent synthetase and ligase
NPA28_09520	COG0300	oxidoreductase activity
NPA28_09525	COG4221	oxidoreductase activity
NPA28_09525	COG3321	synthase
NPA28_09525	COG0300	oxidoreductase activity
NPA28_09525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_09530	COG3321	synthase
NPA28_09530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_09530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA28_09530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_09530	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_09535	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_09535	COG4221	oxidoreductase activity
NPA28_09535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_09535	COG3321	synthase
NPA28_09540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NPA28_09540	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NPA28_09540	COG3321	synthase
NPA28_09540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_09545	COG2124	cytochrome p450
NPA28_09555	COG1404	Belongs to the peptidase S8 family
NPA28_09565	COG4195	phage-related replication protein
NPA28_09570	COG1764	response to oxidative stress
NPA28_09595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NPA28_09600	COG1923	regulation of RNA biosynthetic process
NPA28_09620	COG1780	Probably involved in ribonucleotide reductase function
NPA28_09625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NPA28_09630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NPA28_09635	COG4112	unkown
NPA28_09640	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPA28_09645	COG1131	(ABC) transporter
NPA28_09650	COG0464	growth
NPA28_09655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NPA28_09660	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NPA28_09665	COG0789	Transcriptional regulator
NPA28_09670	COG0174	glutamine synthetase
NPA28_09695	COG2273	Hydrolase Family 16
NPA28_09755	COG0726	polysaccharide deacetylase
NPA28_09790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NPA28_09795	COG2720	vancomycin resistance protein
NPA28_09800	COG3739	integral membrane protein
NPA28_09805	COG3655	Transcriptional regulator
NPA28_09815	COG2135	peptidase activity
NPA28_09820	COG5434	Belongs to the glycosyl hydrolase 28 family
NPA28_09840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NPA28_09850	COG3832	glyoxalase III activity
NPA28_09880	COG4195	phage-related replication protein
NPA28_09900	COG0346	lactoylglutathione lyase activity
NPA28_09910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NPA28_09915	COG1388	LysM domain
NPA28_09920	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NPA28_09925	COG4224	UPF0291 protein
NPA28_09930	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NPA28_09940	COG3763	UPF0154 protein
NPA28_09950	COG0785	Cytochrome C biogenesis protein
NPA28_09955	COG2201	protein-glutamate methylesterase activity
NPA28_09960	COG4846	Membrane protein involved in cytochrome C biogenesis
NPA28_09970	COG0071	Belongs to the small heat shock protein (HSP20) family
NPA28_09985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NPA28_09990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA28_10010	COG0824	Thioesterase
NPA28_10020	COG4841	protein insertion into membrane
NPA28_10025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NPA28_10030	COG1832	CoA-binding protein
NPA28_10035	COG0187	DNA topoisomerase II activity
NPA28_10040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NPA28_10055	COG1115	amino acid carrier protein
NPA28_10060	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NPA28_10085	COG3507	Belongs to the glycosyl hydrolase 43 family
NPA28_10100	COG2246	polysaccharide biosynthetic process
NPA28_10105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NPA28_10110	COG0586	Pfam SNARE associated Golgi protein
NPA28_10115	COG2404	hydrolase activity, acting on ester bonds
NPA28_10120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NPA28_10125	COG1024	Enoyl-CoA hydratase
NPA28_10130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NPA28_10135	COG0511	ligase activity, forming carbon-carbon bonds
NPA28_10140	COG0439	Biotin carboxylase
NPA28_10145	COG0318	PFAM AMP-dependent synthetase and ligase
NPA28_10150	COG1960	acyl-CoA dehydrogenase activity
NPA28_10160	COG1649	PFAM Uncharacterised BCR, COG1649
NPA28_10170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_10170	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NPA28_10175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_10180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_10185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_10190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_10195	COG2027	D-alanyl-D-alanine carboxypeptidase
NPA28_10200	COG2017	converts alpha-aldose to the beta-anomer
NPA28_10205	COG0534	Mate efflux family protein
NPA28_10220	COG0582	viral genome integration into host DNA
NPA28_10225	COG0166	Belongs to the GPI family
NPA28_10230	COG0405	Gamma-glutamyltransferase
NPA28_10235	COG0583	DNA-binding transcription factor activity
NPA28_10240	COG0604	alcohol dehydrogenase
NPA28_10245	COG0493	'glutamate synthase
NPA28_10250	COG0067	glutamate synthase
NPA28_10250	COG0069	glutamate synthase activity
NPA28_10250	COG0070	glutamate synthase
NPA28_10255	COG0583	DNA-binding transcription factor activity
NPA28_10260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NPA28_10280	COG0300	oxidoreductase activity
NPA28_10285	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NPA28_10295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA28_10310	COG1131	(ABC) transporter
NPA28_10320	COG2814	Major facilitator Superfamily
NPA28_10325	COG1070	Carbohydrate kinase
NPA28_10330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NPA28_10335	COG0243	molybdopterin cofactor binding
NPA28_10345	COG4305	rare lipoprotein A
NPA28_10350	COG3619	membrane
NPA28_10360	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_10405	COG2814	Major facilitator Superfamily
NPA28_10415	COG1231	oxidoreductase activity
NPA28_10425	COG1070	Carbohydrate kinase
NPA28_10440	COG3507	Belongs to the glycosyl hydrolase 43 family
NPA28_10445	COG2211	Major facilitator Superfamily
NPA28_10470	COG3397	chitin binding
NPA28_10475	COG2318	DinB family
NPA28_10485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA28_10500	COG0135	phosphoribosylanthranilate isomerase activity
NPA28_10550	COG0457	Tetratricopeptide repeat
NPA28_10565	COG0574	Belongs to the PEP-utilizing enzyme family
NPA28_10565	COG3848	Pyruvate phosphate dikinase
NPA28_10575	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_10580	COG1733	regulation of RNA biosynthetic process
NPA28_10585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPA28_10590	COG2207	Transcriptional regulator
NPA28_10590	COG0662	Cupin 2, conserved barrel domain protein
NPA28_10595	COG0456	acetyltransferase
NPA28_10600	COG1309	transcriptional regulator
NPA28_10605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPA28_10610	COG3708	Transcriptional regulator
NPA28_10615	COG2378	regulation of single-species biofilm formation
NPA28_10625	COG0640	Transcriptional regulator
NPA28_10630	COG0741	lytic transglycosylase activity
NPA28_10635	COG2322	membrane
NPA28_10650	COG1619	proteins homologs of microcin C7 resistance protein MccF
NPA28_10655	COG3239	Fatty acid desaturase
NPA28_10660	COG4585	Histidine kinase
NPA28_10665	COG2197	response regulator
NPA28_10680	COG1388	LysM domain
NPA28_10680	COG3584	3D domain protein
NPA28_10685	COG0514	ATP-dependent DNA helicase (RecQ)
NPA28_10695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NPA28_10700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NPA28_10715	COG1012	belongs to the aldehyde dehydrogenase family
NPA28_10720	COG1657	PFAM Prenyltransferase squalene oxidase
NPA28_10725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NPA28_10730	COG0733	neurotransmitter:sodium symporter activity
NPA28_10735	COG0385	Bile acid
NPA28_10740	COG0508	dehydrogenase complex catalyzes the overall conversion of
NPA28_10745	COG0567	Dehydrogenase, E1 component
NPA28_10750	COG4548	von Willebrand factor, type A
NPA28_10755	COG0714	Associated with various cellular activities
NPA28_10760	COG2032	superoxide dismutase activity
NPA28_10765	COG0791	NLP P60 protein
NPA28_10765	COG1388	LysM domain
NPA28_10770	COG1819	glycosyl
NPA28_10775	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NPA28_10780	COG0534	Mate efflux family protein
NPA28_10785	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA28_10790	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NPA28_10795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NPA28_10805	COG2962	Rard protein
NPA28_10825	COG1942	4-Oxalocrotonate Tautomerase
NPA28_10835	COG1733	regulation of RNA biosynthetic process
NPA28_10840	COG0778	Nitroreductase
NPA28_10845	COG0400	carboxylic ester hydrolase activity
NPA28_10850	COG0346	lactoylglutathione lyase activity
NPA28_10860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NPA28_10865	COG0793	Belongs to the peptidase S41A family
NPA28_10865	COG3409	Peptidoglycan-binding domain 1 protein
NPA28_10870	COG2226	methyltransferase
NPA28_10880	COG1876	peptidase activity
NPA28_10885	COG0813	purine-nucleoside phosphorylase activity
NPA28_10895	COG1309	transcriptional regulator
NPA28_10900	COG2814	Major facilitator Superfamily
NPA28_10920	COG0671	phosphoesterase, PA-phosphatase related
NPA28_10940	COG4479	Belongs to the UPF0346 family
NPA28_10950	COG1509	lysine 2,3-aminomutase activity
NPA28_10955	COG0456	acetyltransferase
NPA28_10960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NPA28_10965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NPA28_10970	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NPA28_10975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NPA28_10985	COG0456	acetyltransferase
NPA28_10990	COG0463	Glycosyl transferase, family 2
NPA28_11005	COG4641	Protein conserved in bacteria
NPA28_11010	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
NPA28_11025	COG3331	DNA recombination
NPA28_11035	COG0457	Tetratricopeptide repeat
NPA28_11040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA28_11050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NPA28_11055	COG2226	methyltransferase
NPA28_11060	COG2211	Major facilitator Superfamily
NPA28_11085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA28_11105	COG5444	nuclease activity
NPA28_11110	COG4282	regulation of fungal-type cell wall biogenesis
NPA28_11140	COG0577	efflux transmembrane transporter activity
NPA28_11140	COG1136	(ABC) transporter
NPA28_11160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NPA28_11165	COG1086	Polysaccharide biosynthesis protein
NPA28_11175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NPA28_11180	COG1846	Transcriptional regulator
NPA28_11185	COG0534	Mate efflux family protein
NPA28_11195	COG4698	Protein conserved in bacteria
NPA28_11200	COG2755	lipolytic protein G-D-S-L family
NPA28_11205	COG1999	signal sequence binding
NPA28_11215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NPA28_11220	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NPA28_11225	COG1272	protein, Hemolysin III
NPA28_11230	COG0204	Acyl-transferase
NPA28_11235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NPA28_11245	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NPA28_11255	COG2136	Putative SAM-dependent methyltransferase
NPA28_11255	COG2521	methyltransferase
NPA28_11265	COG0129	dihydroxy-acid dehydratase activity
NPA28_11270	COG1413	lyase activity
NPA28_11275	COG1418	mRNA catabolic process
NPA28_11280	COG0386	Belongs to the glutathione peroxidase family
NPA28_11285	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NPA28_11290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NPA28_11300	COG1278	Cold shock
NPA28_11320	COG0328	RNA-DNA hybrid ribonuclease activity
NPA28_11325	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NPA28_11330	COG0328	RNA-DNA hybrid ribonuclease activity
NPA28_11340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NPA28_11355	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NPA28_11365	COG1755	Isoprenylcysteine carboxyl methyltransferase
NPA28_11370	COG3424	synthase
NPA28_11375	COG2233	PERMEase
NPA28_11380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NPA28_11385	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NPA28_11395	COG0800	Aldolase
NPA28_11400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NPA28_11405	COG1609	Transcriptional regulator
NPA28_11410	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NPA28_11415	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_11420	COG1199	ATP-dependent helicase activity
NPA28_11435	COG0116	Belongs to the methyltransferase superfamily
NPA28_11450	COG4474	Belongs to the UPF0398 family
NPA28_11465	COG3359	exonuclease
NPA28_11470	COG1111	helicase
NPA28_11470	COG1205	dead DEAH box helicase
NPA28_11475	COG2190	(PTS) system
NPA28_11480	COG0071	Belongs to the small heat shock protein (HSP20) family
NPA28_11515	COG3331	DNA recombination
NPA28_11520	COG4499	WXG100 protein secretion system (Wss), protein YukC
NPA28_11520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NPA28_11530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NPA28_11535	COG3935	DnaD domain protein
NPA28_11540	COG0017	Asparaginyl-tRNA synthetase
NPA28_11545	COG0436	Aminotransferase
NPA28_11550	COG5353	protein conserved in bacteria
NPA28_11560	COG1199	ATP-dependent helicase activity
NPA28_11560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NPA28_11565	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NPA28_11570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NPA28_11575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NPA28_11580	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NPA28_11580	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NPA28_11585	COG0617	tRNA 3'-terminal CCA addition
NPA28_11590	COG0438	transferase activity, transferring glycosyl groups
NPA28_11595	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NPA28_11600	COG1803	Methylglyoxal synthase
NPA28_11605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NPA28_11610	COG1694	Mazg nucleotide pyrophosphohydrolase
NPA28_11615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA28_11625	COG4347	Protein of unknown function (DUF1405)
NPA28_11630	COG2010	Cytochrome c
NPA28_11630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NPA28_11635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NPA28_11640	COG0723	plastoquinol--plastocyanin reductase activity
NPA28_11650	COG5582	Belongs to the UPF0302 family
NPA28_11655	COG0457	Tetratricopeptide repeat
NPA28_11660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NPA28_11665	COG0287	Prephenate dehydrogenase
NPA28_11670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NPA28_11675	COG0159	tryptophan synthase activity
NPA28_11680	COG0133	tryptophan synthase activity
NPA28_11685	COG0135	phosphoribosylanthranilate isomerase activity
NPA28_11695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NPA28_11700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NPA28_11705	COG4401	Chorismate mutase type I
NPA28_11710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NPA28_11715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NPA28_11720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NPA28_11725	COG0105	UTP biosynthetic process
NPA28_11730	COG0142	geranyltranstransferase activity
NPA28_11735	COG2226	methyltransferase
NPA28_11740	COG0142	geranyltranstransferase activity
NPA28_11750	COG0302	gtp cyclohydrolase
NPA28_11755	COG0776	regulation of translation
NPA28_11760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NPA28_11775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NPA28_11780	COG1160	GTP binding
NPA28_11805	COG1304	FMN binding
NPA28_11810	COG0539	negative regulation of cytoplasmic translation
NPA28_11815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NPA28_11825	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NPA28_11830	COG2959	enzyme of heme biosynthesis
NPA28_11835	COG3409	Peptidoglycan-binding domain 1 protein
NPA28_11835	COG3773	Cell wall hydrolase
NPA28_11840	COG2339	peptidase activity
NPA28_11845	COG0492	ferredoxin-NADP+ reductase activity
NPA28_11850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NPA28_11855	COG4862	establishment of competence for transformation
NPA28_11860	COG1408	metallophosphoesterase
NPA28_11870	COG1388	LysM domain
NPA28_11875	COG1266	CAAX protease self-immunity
NPA28_11880	COG0514	ATP-dependent DNA helicase (RecQ)
NPA28_11885	COG4955	Helix-turn-helix domain
NPA28_11890	COG1141	Ferredoxin
NPA28_11895	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NPA28_11900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NPA28_11905	COG0710	3-dehydroquinate dehydratase activity
NPA28_11915	COG1595	DNA-templated transcription, initiation
NPA28_11920	COG5002	protein histidine kinase activity
NPA28_11925	COG0745	RESPONSE REGULATOR receiver
NPA28_11930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NPA28_11935	COG1333	cytochrome c biogenesis protein
NPA28_11940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA28_11945	COG1187	pseudouridine synthase activity
NPA28_11950	COG0700	Nucleoside recognition
NPA28_11955	COG2715	membrane protein required for spore maturation
NPA28_11960	COG1686	Belongs to the peptidase S11 family
NPA28_11970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NPA28_11975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NPA28_11985	COG1547	Domain of unknown function (DUF309)
NPA28_11990	COG0456	acetyltransferase
NPA28_11995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NPA28_12000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NPA28_12000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NPA28_12005	COG0307	riboflavin synthase, alpha
NPA28_12010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NPA28_12010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NPA28_12020	COG0681	Belongs to the peptidase S26 family
NPA28_12025	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
NPA28_12030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NPA28_12035	COG4086	secreted protein
NPA28_12040	COG0019	diaminopimelate decarboxylase activity
NPA28_12045	COG0697	spore germination
NPA28_12060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NPA28_12080	COG1191	sigma factor activity
NPA28_12085	COG2172	sigma factor antagonist activity
NPA28_12090	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA28_12095	COG1686	Belongs to the peptidase S11 family
NPA28_12100	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NPA28_12105	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NPA28_12110	COG4974	Belongs to the 'phage' integrase family
NPA28_12120	COG0735	belongs to the Fur family
NPA28_12125	COG1300	Membrane
NPA28_12135	COG0281	malic enzyme
NPA28_12140	COG1757	Na H antiporter
NPA28_12145	COG1027	Aspartate ammonia-lyase
NPA28_12150	COG0252	asparaginase activity
NPA28_12155	COG1396	sequence-specific DNA binding
NPA28_12160	COG1379	DNA repair
NPA28_12165	COG0494	nUDIX hydrolase
NPA28_12175	COG0667	Aldo Keto reductase
NPA28_12185	COG1073	alpha beta
NPA28_12195	COG4918	Iron-sulphur cluster biosynthesis
NPA28_12200	COG0456	acetyltransferase
NPA28_12200	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NPA28_12210	COG0456	acetyltransferase
NPA28_12220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NPA28_12230	COG2211	Major facilitator Superfamily
NPA28_12245	COG1072	(Pantothenic acid kinase))
NPA28_12250	COG3048	D-serine ammonia-lyase activity
NPA28_12255	COG0300	oxidoreductase activity
NPA28_12260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPA28_12265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NPA28_12270	COG4187	Peptidase family M20/M25/M40
NPA28_12275	COG1902	pentaerythritol trinitrate reductase activity
NPA28_12280	COG0596	Alpha beta hydrolase
NPA28_12290	COG1234	tRNA 3'-trailer cleavage
NPA28_12295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NPA28_12305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NPA28_12310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NPA28_12320	COG0706	membrane insertase activity
NPA28_12325	COG3361	conserved protein (COG2071)
NPA28_12330	COG2195	Cleaves the N-terminal amino acid of tripeptides
NPA28_12335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NPA28_12340	COG0346	lactoylglutathione lyase activity
NPA28_12350	COG1376	ErfK ybiS ycfS ynhG family protein
NPA28_12355	COG4129	membrane
NPA28_12360	COG1126	abc transporter atp-binding protein
NPA28_12365	COG0765	amino acid transport
NPA28_12370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA28_12380	COG1597	lipid kinase activity
NPA28_12385	COG2814	Major facilitator Superfamily
NPA28_12390	COG0789	Transcriptional regulator
NPA28_12390	COG4978	Transcriptional regulator
NPA28_12395	COG0508	dehydrogenase complex catalyzes the overall conversion of
NPA28_12400	COG0022	dehydrogenase e1 component
NPA28_12405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NPA28_12410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NPA28_12415	COG3426	butyrate kinase activity
NPA28_12420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NPA28_12425	COG0280	phosphate acetyltransferase
NPA28_12430	COG3290	protein histidine kinase activity
NPA28_12430	COG3829	transcription factor binding
NPA28_12440	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NPA28_12445	COG2079	MmgE PrpD family protein
NPA28_12450	COG0372	Belongs to the citrate synthase family
NPA28_12455	COG1960	acyl-CoA dehydrogenase activity
NPA28_12460	COG1250	3-hydroxyacyl-CoA dehydrogenase
NPA28_12465	COG0183	Belongs to the thiolase family
NPA28_12470	COG0584	glycerophosphoryl diester phosphodiesterase
NPA28_12475	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPA28_12490	COG1902	pentaerythritol trinitrate reductase activity
NPA28_12495	COG0745	RESPONSE REGULATOR receiver
NPA28_12500	COG0750	zinc metalloprotease
NPA28_12505	COG0497	DNA recombination
NPA28_12510	COG1438	arginine binding
NPA28_12515	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NPA28_12520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NPA28_12525	COG0142	geranyltranstransferase activity
NPA28_12530	COG1722	exodeoxyribonuclease VII activity
NPA28_12535	COG1570	exodeoxyribonuclease VII activity
NPA28_12540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NPA28_12545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NPA28_12550	COG1302	Protein conserved in bacteria
NPA28_12555	COG0439	Biotin carboxylase
NPA28_12560	COG0511	ligase activity, forming carbon-carbon bonds
NPA28_12600	COG3854	ATPases associated with a variety of cellular activities
NPA28_12610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NPA28_12615	COG0006	proline dipeptidase activity
NPA28_12620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NPA28_12630	COG3872	metal-dependent enzyme
NPA28_12640	COG1752	Esterase of the alpha-beta hydrolase superfamily
NPA28_12645	COG1321	iron dependent repressor
NPA28_12650	COG0095	Lipoate-protein ligase
NPA28_12655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NPA28_12660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NPA28_12665	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NPA28_12670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NPA28_12675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NPA28_12690	COG1396	sequence-specific DNA binding
NPA28_12700	COG0681	Belongs to the peptidase S26 family
NPA28_12725	COG4940	Competence protein ComGF
NPA28_12735	COG4970	Tfp pilus assembly protein FimT
NPA28_12740	COG4537	Required for transformation and DNA binding
NPA28_12745	COG1459	type II secretion system
NPA28_12750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NPA28_12755	COG0517	IMP dehydrogenase activity
NPA28_12760	COG0598	Magnesium transport protein CorA
NPA28_12770	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA28_12780	COG1393	Belongs to the ArsC family
NPA28_12790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPA28_12800	COG0011	TIGRFAM Protein of
NPA28_12810	COG2866	Carboxypeptidase
NPA28_12815	COG1368	sulfuric ester hydrolase activity
NPA28_12820	COG1940	carbohydrate kinase activity
NPA28_12825	COG4483	Protein conserved in bacteria
NPA28_12830	COG0705	Rhomboid family
NPA28_12830	COG0457	Tetratricopeptide repeat
NPA28_12840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NPA28_12850	COG0438	transferase activity, transferring glycosyl groups
NPA28_12865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NPA28_12870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NPA28_12875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NPA28_12880	COG0581	inorganic phosphate transmembrane transporter activity
NPA28_12885	COG0573	inorganic phosphate transmembrane transporter activity
NPA28_12890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NPA28_12895	COG0768	penicillin binding
NPA28_12900	COG0477	Major facilitator Superfamily
NPA28_12905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NPA28_12910	COG2839	Protein conserved in bacteria
NPA28_12915	COG5521	maltodextrose utilization protein MalA
NPA28_12920	COG1388	LysM domain
NPA28_12925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NPA28_12930	COG4709	membrane
NPA28_12935	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
NPA28_12940	COG0735	belongs to the Fur family
NPA28_12945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA28_12955	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NPA28_12960	COG0513	Belongs to the DEAD box helicase family
NPA28_12970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NPA28_12975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NPA28_12980	COG2384	SAM-dependent methyltransferase
NPA28_12985	COG2010	Cytochrome c
NPA28_12990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NPA28_12995	COG0358	DNA primase activity
NPA28_13000	COG1671	Belongs to the UPF0178 family
NPA28_13005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NPA28_13010	COG0517	IMP dehydrogenase activity
NPA28_13015	COG0751	glycine-tRNA ligase activity
NPA28_13020	COG0752	glycyl-tRNA synthetase alpha subunit
NPA28_13025	COG1381	Involved in DNA repair and RecF pathway recombination
NPA28_13035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NPA28_13040	COG0295	cytidine deaminase activity
NPA28_13045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NPA28_13050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NPA28_13055	COG1480	7TM receptor with intracellular HD hydrolase
NPA28_13060	COG1702	phosphate starvation-inducible protein PhoH
NPA28_13065	COG0561	phosphatase activity
NPA28_13080	COG4864	UPF0365 protein
NPA28_13085	COG1030	water channel activity
NPA28_13090	COG1610	YqeY-like protein
NPA28_13100	COG1283	sodium-dependent phosphate transmembrane transporter activity
NPA28_13105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NPA28_13110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NPA28_13115	COG2264	protein methyltransferase activity
NPA28_13120	COG0484	heat shock protein binding
NPA28_13130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NPA28_13135	COG1420	regulation of RNA biosynthetic process
NPA28_13140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NPA28_13145	COG0481	GTPase activity
NPA28_13155	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPA28_13160	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NPA28_13170	COG1466	dna polymerase III delta subunit
NPA28_13185	COG0658	competence protein
NPA28_13185	COG2333	competence protein COMEC
NPA28_13190	COG2131	deaminase
NPA28_13195	COG1555	photosystem II stabilization
NPA28_13195	COG1596	polysaccharide export
NPA28_13200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NPA28_13205	COG2226	methyltransferase
NPA28_13210	COG0799	negative regulation of ribosome biogenesis
NPA28_13215	COG1713	HD superfamily hydrolase involved in NAD metabolism
NPA28_13220	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NPA28_13225	COG1534	Rna-binding protein
NPA28_13230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NPA28_13235	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NPA28_13240	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NPA28_13255	COG2755	lipolytic protein G-D-S-L family
NPA28_13260	COG3409	Peptidoglycan-binding domain 1 protein
NPA28_13260	COG5632	N-Acetylmuramoyl-L-alanine amidase
NPA28_13265	COG0398	Pfam SNARE associated Golgi protein
NPA28_13270	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NPA28_13280	COG3209	COG3209 Rhs family protein
NPA28_13300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NPA28_13305	COG0798	PFAM Bile acid sodium symporter
NPA28_13310	COG0346	lactoylglutathione lyase activity
NPA28_13315	COG0640	Transcriptional regulator
NPA28_13335	COG0604	alcohol dehydrogenase
NPA28_13345	COG2315	Protein conserved in bacteria
NPA28_13350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NPA28_13355	COG0457	Tetratricopeptide repeat
NPA28_13360	COG5444	nuclease activity
NPA28_13370	COG5632	N-Acetylmuramoyl-L-alanine amidase
NPA28_13370	COG3409	Peptidoglycan-binding domain 1 protein
NPA28_13370	COG1388	LysM domain
NPA28_13375	COG4824	toxin secretion phage lysis holin
NPA28_13390	COG1794	racemase activity, acting on amino acids and derivatives
NPA28_13410	COG0563	adenylate kinase activity
NPA28_13415	COG2856	Zn peptidase
NPA28_13430	COG3223	Belongs to the PsiE family
NPA28_13435	COG5002	protein histidine kinase activity
NPA28_13435	COG0642	Histidine kinase
NPA28_13440	COG0745	RESPONSE REGULATOR receiver
NPA28_13445	COG2311	Membrane
NPA28_13450	COG0454	-acetyltransferase
NPA28_13470	COG5002	protein histidine kinase activity
NPA28_13475	COG0745	RESPONSE REGULATOR receiver
NPA28_13485	COG2732	(Barnase) inhibitor
NPA28_13510	COG1725	Transcriptional regulator
NPA28_13545	COG3443	Belongs to the bacterial solute-binding protein 9 family
NPA28_13550	COG4991	sh3 domain protein
NPA28_13555	COG4991	sh3 domain protein
NPA28_13585	COG0693	protein deglycase activity
NPA28_13590	COG1621	beta-fructofuranosidase activity
NPA28_13595	COG3716	PTS system mannose fructose sorbose family IID component
NPA28_13600	COG3715	PTS system
NPA28_13605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA28_13610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA28_13615	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NPA28_13615	COG3933	PFAM sigma-54 factor interaction domain-containing protein
NPA28_13625	COG1280	lysine exporter protein (LysE YggA)
NPA28_13630	COG1378	Sugar-specific transcriptional regulator TrmB
NPA28_13635	COG1595	DNA-templated transcription, initiation
NPA28_13645	COG2755	lipolytic protein G-D-S-L family
NPA28_13645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NPA28_13655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NPA28_13655	COG2124	cytochrome p450
NPA28_13660	COG1309	transcriptional regulator
NPA28_13665	COG2226	methyltransferase
NPA28_13680	COG2116	formate transmembrane transporter activity
NPA28_13685	COG5609	conserved protein (DUF2294)
NPA28_13690	COG3383	formate dehydrogenase (NAD+) activity
NPA28_13695	COG2427	Protein of unknown function (DUF1641)
NPA28_13705	COG0626	cystathionine gamma-synthase activity
NPA28_13710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NPA28_13715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NPA28_13720	COG2226	methyltransferase
NPA28_13735	COG0768	penicillin binding
NPA28_13740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NPA28_13745	COG0572	uridine kinase
NPA28_13750	COG0826	peptidase U32
NPA28_13755	COG0826	peptidase U32
NPA28_13760	COG4122	O-methyltransferase activity
NPA28_13765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NPA28_13770	COG3906	Belongs to the UPF0473 family
NPA28_13775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NPA28_13780	COG4472	Bacterial protein of unknown function (DUF965)
NPA28_13785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NPA28_13790	COG0628	permease
NPA28_13795	COG1126	abc transporter atp-binding protein
NPA28_13800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA28_13805	COG0765	amino acid transport
NPA28_13810	COG0765	amino acid transport
NPA28_13825	COG3881	PFAM PRC-barrel domain
NPA28_13830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NPA28_13835	COG0457	Tetratricopeptide repeat
NPA28_13840	COG0482	sulfurtransferase activity
NPA28_13845	COG1104	cysteine desulfurase activity
NPA28_13850	COG1959	2 iron, 2 sulfur cluster binding
NPA28_13855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NPA28_13860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NPA28_13870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NPA28_13875	COG0124	histidyl-tRNA synthetase
NPA28_13885	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPA28_13885	COG4991	sh3 domain protein
NPA28_13885	COG3103	Sh3 type 3 domain protein
NPA28_13890	COG1490	D-aminoacyl-tRNA deacylase activity
NPA28_13895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NPA28_13900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NPA28_13905	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NPA28_13905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NPA28_13910	COG5416	Lipopolysaccharide assembly protein A domain
NPA28_13915	COG0490	domain, Protein
NPA28_13920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NPA28_13920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NPA28_13930	COG2244	polysaccharide biosynthetic process
NPA28_13935	COG2323	membrane
NPA28_13945	COG1862	Preprotein translocase
NPA28_13950	COG0343	queuine tRNA-ribosyltransferase activity
NPA28_13955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NPA28_13965	COG2255	four-way junction helicase activity
NPA28_13970	COG0632	four-way junction helicase activity
NPA28_13980	COG2814	Major facilitator Superfamily
NPA28_13985	COG0673	inositol 2-dehydrogenase activity
NPA28_13990	COG2112	serine threonine protein kinase
NPA28_14005	COG1115	amino acid carrier protein
NPA28_14010	COG0217	transcriptional regulatory protein
NPA28_14020	COG1388	LysM domain
NPA28_14025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NPA28_14030	COG0157	Belongs to the NadC ModD family
NPA28_14035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NPA28_14040	COG1104	cysteine desulfurase activity
NPA28_14045	COG1827	regulation of RNA biosynthetic process
NPA28_14050	COG0077	Prephenate dehydratase
NPA28_14055	COG4492	Belongs to the UPF0735 family
NPA28_14060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NPA28_14065	COG3290	protein histidine kinase activity
NPA28_14075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NPA28_14080	COG2868	ribosomal protein
NPA28_14085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NPA28_14090	COG1994	Peptidase M50
NPA28_14095	COG0739	heme binding
NPA28_14100	COG2894	cell division
NPA28_14105	COG0850	regulation of cytokinetic process
NPA28_14110	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NPA28_14120	COG1077	Cell shape determining protein MreB Mrl
NPA28_14125	COG2003	Belongs to the UPF0758 family
NPA28_14130	COG0424	maF-like protein
NPA28_14140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NPA28_14145	COG0285	dihydrofolate synthase activity
NPA28_14150	COG0525	valine-tRNA ligase activity
NPA28_14160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NPA28_14165	COG1388	LysM domain
NPA28_14170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NPA28_14175	COG0113	porphobilinogen synthase activity
NPA28_14180	COG1587	Uroporphyrinogen-III synthase
NPA28_14185	COG0181	hydroxymethylbilane synthase activity
NPA28_14190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NPA28_14195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NPA28_14205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NPA28_14210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NPA28_14215	COG0470	DNA polymerase III
NPA28_14215	COG1067	ATP-dependent peptidase activity
NPA28_14220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NPA28_14225	COG0544	peptidyl-prolyl cis-trans isomerase activity
NPA28_14230	COG1477	protein flavinylation
NPA28_14230	COG0457	Tetratricopeptide repeat
NPA28_14235	COG0066	3-isopropylmalate dehydratase activity
NPA28_14240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NPA28_14245	COG0473	3-isopropylmalate dehydrogenase activity
NPA28_14250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NPA28_14255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NPA28_14260	COG0440	acetolactate synthase activity
NPA28_14265	COG0028	Belongs to the TPP enzyme family
NPA28_14275	COG0454	-acetyltransferase
NPA28_14285	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NPA28_14295	COG0622	Phosphoesterase
NPA28_14300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NPA28_14305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NPA28_14310	COG5401	PFAM Sporulation and spore germination
NPA28_14315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NPA28_14320	COG1846	Transcriptional regulator
NPA28_14325	COG2197	response regulator
NPA28_14330	COG0824	Thioesterase
NPA28_14335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NPA28_14340	COG1053	succinate dehydrogenase
NPA28_14345	COG2009	succinate dehydrogenase
NPA28_14350	COG1719	4-vinyl reductase, 4VR
NPA28_14355	COG0527	aspartate kinase activity
NPA28_14360	COG0322	excinuclease ABC activity
NPA28_14365	COG3118	belongs to the thioredoxin family
NPA28_14370	COG3534	alpha-L-arabinofuranosidase
NPA28_14375	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NPA28_14380	COG2086	electron transfer activity
NPA28_14385	COG1024	Enoyl-CoA hydratase
NPA28_14390	COG1309	transcriptional regulator
NPA28_14395	COG0318	PFAM AMP-dependent synthetase and ligase
NPA28_14400	COG3766	membrane
NPA28_14405	COG1193	negative regulation of DNA recombination
NPA28_14410	COG1796	DNA polymerase
NPA28_14410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NPA28_14415	COG1286	toxin biosynthetic process
NPA28_14420	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NPA28_14425	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NPA28_14430	COG0072	phenylalanine-tRNA ligase activity
NPA28_14430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPA28_14435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NPA28_14445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NPA28_14455	COG3835	regulator
NPA28_14460	COG0277	FAD linked oxidase domain protein
NPA28_14465	COG0247	lactate metabolic process
NPA28_14470	COG0346	lactoylglutathione lyase activity
NPA28_14475	COG1966	Carbon starvation protein
NPA28_14490	COG1695	Transcriptional regulator
NPA28_14495	COG3534	alpha-L-arabinofuranosidase
NPA28_14500	COG0395	ABC-type sugar transport system, permease component
NPA28_14505	COG1175	transmembrane transport
NPA28_14510	COG1653	transport
NPA28_14515	COG0371	Dehydrogenase
NPA28_14520	COG0647	UMP catabolic process
NPA28_14525	COG0235	Class ii aldolase
NPA28_14530	COG1069	ribulokinase activity
NPA28_14535	COG2160	L-arabinose isomerase activity
NPA28_14540	COG3507	Belongs to the glycosyl hydrolase 43 family
NPA28_14545	COG1363	Peptidase, m42
NPA28_14555	COG3326	Membrane
NPA28_14560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NPA28_14565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NPA28_14570	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NPA28_14585	COG1346	cytolysis
NPA28_14590	COG1380	Effector of murein hydrolase LrgA
NPA28_14595	COG3279	Response regulator of the LytR AlgR family
NPA28_14600	COG3275	phosphorelay sensor kinase activity
NPA28_14605	COG1011	Hydrolase
NPA28_14610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NPA28_14620	COG0398	Pfam SNARE associated Golgi protein
NPA28_14625	COG1484	DNA-dependent DNA replication
NPA28_14630	COG3611	Membrane attachment protein
NPA28_14635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NPA28_14640	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NPA28_14645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NPA28_14650	COG1733	regulation of RNA biosynthetic process
NPA28_14655	COG2814	Major facilitator Superfamily
NPA28_14660	COG0656	L-ascorbic acid biosynthetic process
NPA28_14665	COG0237	dephospho-CoA kinase activity
NPA28_14675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NPA28_14680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NPA28_14680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NPA28_14685	COG5002	protein histidine kinase activity
NPA28_14690	COG0745	RESPONSE REGULATOR receiver
NPA28_14695	COG0039	L-malate dehydrogenase activity
NPA28_14700	COG0538	isocitrate dehydrogenase activity
NPA28_14705	COG0372	Belongs to the citrate synthase family
NPA28_14710	COG2707	UPF0756 membrane protein
NPA28_14715	COG0628	permease
NPA28_14720	COG3030	protein affecting phage T7 exclusion by the F plasmid
NPA28_14725	COG0469	pyruvate kinase activity
NPA28_14730	COG0205	6-phosphofructokinase activity
NPA28_14735	COG0825	malonyl-CoA metabolic process
NPA28_14740	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NPA28_14745	COG0281	malic enzyme
NPA28_14750	COG0587	DNA-directed DNA polymerase activity
NPA28_14770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NPA28_14780	COG4109	DRTGG domain
NPA28_14785	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NPA28_14790	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_14800	COG0165	Argininosuccinate lyase
NPA28_14805	COG0137	argininosuccinate synthase activity
NPA28_14810	COG0521	Mo-molybdopterin cofactor biosynthetic process
NPA28_14815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NPA28_14820	COG0827	DNA restriction-modification system
NPA28_14825	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NPA28_14830	COG3874	Sporulation protein YtfJ
NPA28_14840	COG1714	RDD family
NPA28_14845	COG0616	signal peptide processing
NPA28_14850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NPA28_14855	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NPA28_14860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NPA28_14870	COG0301	tRNA thio-modification
NPA28_14875	COG1104	cysteine desulfurase activity
NPA28_14880	COG1114	Component of the transport system for branched-chain amino acids
NPA28_14885	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NPA28_14890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NPA28_14895	COG1309	transcriptional regulator
NPA28_14900	COG1956	GAF domain-containing protein
NPA28_14905	COG2199	diguanylate cyclase activity
NPA28_14905	COG2203	Gaf domain
NPA28_14920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NPA28_14925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NPA28_14930	COG0454	-acetyltransferase
NPA28_14935	COG0517	IMP dehydrogenase activity
NPA28_14940	COG0123	including yeast histone deacetylase and acetoin utilization protein
NPA28_14945	COG1360	Flagellar Motor Protein
NPA28_14950	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NPA28_14955	COG1609	Transcriptional regulator
NPA28_14960	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NPA28_14960	COG1605	Chorismate mutase
NPA28_14965	COG3118	belongs to the thioredoxin family
NPA28_14970	COG4980	gas vesicle protein
NPA28_14975	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NPA28_14980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NPA28_14985	COG1674	ftsk spoiiie
NPA28_14990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPA28_14995	COG4848	Belongs to the UPF0354 family
NPA28_15000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA28_15015	COG1363	Peptidase, m42
NPA28_15020	COG5584	Small secreted protein
NPA28_15025	COG0281	malic enzyme
NPA28_15030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPA28_15035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NPA28_15045	COG0510	thiamine kinase activity
NPA28_15050	COG1523	belongs to the glycosyl hydrolase 13 family
NPA28_15055	COG1597	lipid kinase activity
NPA28_15065	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NPA28_15070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NPA28_15075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NPA28_15080	COG2252	PERMEase
NPA28_15085	COG4473	ABC transporter
NPA28_15090	COG1131	(ABC) transporter
NPA28_15095	COG1349	DNA-binding transcription factor activity
NPA28_15100	COG1187	pseudouridine synthase activity
NPA28_15105	COG2244	polysaccharide biosynthetic process
NPA28_15110	COG2081	HI0933 family
NPA28_15115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NPA28_15125	COG5578	integral membrane protein
NPA28_15130	COG0673	inositol 2-dehydrogenase activity
NPA28_15135	COG1653	transport
NPA28_15140	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NPA28_15145	COG4209	transmembrane transport
NPA28_15150	COG2207	Transcriptional regulator
NPA28_15155	COG1653	transport
NPA28_15160	COG0395	ABC-type sugar transport system, permease component
NPA28_15165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA28_15170	COG2124	cytochrome p450
NPA28_15175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NPA28_15185	COG0156	8-amino-7-oxononanoate synthase activity
NPA28_15190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NPA28_15200	COG1073	alpha beta
NPA28_15205	COG1609	Transcriptional regulator
NPA28_15210	COG1653	transport
NPA28_15215	COG1175	transmembrane transport
NPA28_15220	COG0395	ABC-type sugar transport system, permease component
NPA28_15225	COG1486	melibiose metabolic process
NPA28_15230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NPA28_15235	COG0495	leucyl-tRNA aminoacylation
NPA28_15245	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA28_15245	COG2202	Pas domain
NPA28_15250	COG2814	Major facilitator Superfamily
NPA28_15255	COG2433	Pfam Transposase IS66
NPA28_15260	COG0577	efflux transmembrane transporter activity
NPA28_15265	COG1136	(ABC) transporter
NPA28_15270	COG2205	protein histidine kinase activity
NPA28_15275	COG0745	RESPONSE REGULATOR receiver
NPA28_15280	COG0577	efflux transmembrane transporter activity
NPA28_15285	COG1136	(ABC) transporter
NPA28_15300	COG1131	(ABC) transporter
NPA28_15305	COG1725	Transcriptional regulator
NPA28_15320	COG1242	4 iron, 4 sulfur cluster binding
NPA28_15325	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NPA28_15335	COG2267	carboxylic ester hydrolase activity
NPA28_15340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NPA28_15345	COG1113	amino acid transport
NPA28_15350	COG0367	asparagine synthase
NPA28_15355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NPA28_15360	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NPA28_15370	COG1506	peptidase
NPA28_15375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NPA28_15380	COG1116	anion transmembrane transporter activity
NPA28_15385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NPA28_15390	COG0494	nUDIX hydrolase
NPA28_15395	COG4824	toxin secretion phage lysis holin
NPA28_15400	COG0783	Belongs to the Dps family
NPA28_15415	COG1854	S-ribosylhomocysteine lyase activity
NPA28_15420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NPA28_15425	COG0288	reversible hydration of carbon dioxide
NPA28_15430	COG0254	rRNA binding
NPA28_15435	COG1271	oxidase subunit
NPA28_15440	COG1294	oxidase, subunit
NPA28_15450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NPA28_15455	COG1321	iron dependent repressor
NPA28_15455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NPA28_15460	COG1121	(ABC) transporter
NPA28_15465	COG0803	Belongs to the bacterial solute-binding protein 9 family
NPA28_15470	COG4948	Mandelate Racemase Muconate Lactonizing
NPA28_15475	COG0318	PFAM AMP-dependent synthetase and ligase
NPA28_15480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NPA28_15485	COG0596	Alpha beta hydrolase
NPA28_15490	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NPA28_15495	COG1169	isochorismate synthase
NPA28_15500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NPA28_15505	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NPA28_15510	COG0058	SHG alpha-glucan phosphorylase activity
NPA28_15515	COG0297	glycogen (starch) synthase activity
NPA28_15520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NPA28_15525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NPA28_15530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NPA28_15655	COG3859	Proton-coupled thiamine transporter YuaJ
NPA28_15660	COG1247	-acetyltransferase
NPA28_15665	COG2268	Band 7 protein
NPA28_15670	COG1585	Membrane protein implicated in regulation of membrane protease activity
NPA28_15675	COG2318	DinB family
NPA28_15685	COG1454	alcohol dehydrogenase
NPA28_15690	COG1012	belongs to the aldehyde dehydrogenase family
NPA28_15695	COG1510	regulation of RNA biosynthetic process
NPA28_15705	COG0569	domain protein
NPA28_15710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NPA28_15715	COG4682	membrane
NPA28_15720	COG1705	Flagellar rod assembly protein muramidase FlgJ
NPA28_15725	COG0477	Major facilitator Superfamily
NPA28_15730	COG5553	Cysteine dioxygenase type I
NPA28_15740	COG1968	undecaprenyl-diphosphatase activity
NPA28_15745	COG0628	permease
NPA28_15750	COG0673	inositol 2-dehydrogenase activity
NPA28_15755	COG4806	L-rhamnose isomerase
NPA28_15760	COG3254	rhamnose metabolic process
NPA28_15765	COG1070	Carbohydrate kinase
NPA28_15770	COG1349	DNA-binding transcription factor activity
NPA28_15775	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_15775	COG3347	Dehydrogenase
NPA28_15780	COG0840	transmembrane signaling receptor activity
NPA28_15785	COG0840	transmembrane signaling receptor activity
NPA28_15790	COG0840	transmembrane signaling receptor activity
NPA28_15795	COG0840	transmembrane signaling receptor activity
NPA28_15810	COG2070	2-Nitropropane dioxygenase
NPA28_15815	COG0432	Pfam Uncharacterised protein family UPF0047
NPA28_15820	COG0366	Alpha amylase catalytic
NPA28_15825	COG1253	flavin adenine dinucleotide binding
NPA28_15830	COG2738	Putative neutral zinc metallopeptidase
NPA28_15845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NPA28_15860	COG0166	Belongs to the GPI family
NPA28_15865	COG1979	alcohol dehydrogenase
NPA28_15870	COG1979	alcohol dehydrogenase
NPA28_15875	COG2155	Conserved Protein
NPA28_15880	COG1098	S1 RNA binding domain
NPA28_15885	COG0436	Aminotransferase
NPA28_15890	COG1522	sequence-specific DNA binding
NPA28_15895	COG2267	carboxylic ester hydrolase activity
NPA28_15905	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NPA28_15910	COG2205	protein histidine kinase activity
NPA28_15920	COG5018	Exonuclease
NPA28_15930	COG2814	Major facilitator Superfamily
NPA28_15935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NPA28_15940	COG3011	Protein conserved in bacteria
NPA28_15950	COG3290	protein histidine kinase activity
NPA28_15955	COG4565	transcriptional regulatory protein
NPA28_15960	COG1744	ABC transporter substrate-binding protein PnrA-like
NPA28_15965	COG3845	ABC transporter
NPA28_15970	COG4603	Belongs to the binding-protein-dependent transport system permease family
NPA28_15975	COG1079	Belongs to the binding-protein-dependent transport system permease family
NPA28_15980	COG3493	citrate carrier protein
NPA28_15990	COG2111	Na H antiporter
NPA28_15990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NPA28_15995	COG2111	Na H antiporter
NPA28_16000	COG1006	Multisubunit Na H antiporter MnhC subunit
NPA28_16005	COG0651	ATP synthesis coupled electron transport
NPA28_16010	COG1863	multisubunit Na H antiporter MnhE subunit
NPA28_16015	COG2212	antiporter activity
NPA28_16020	COG1320	monovalent cation:proton antiporter activity
NPA28_16025	COG2050	protein possibly involved in aromatic compounds catabolism
NPA28_16030	COG2197	response regulator
NPA28_16035	COG4585	Histidine kinase
NPA28_16045	COG0142	geranyltranstransferase activity
NPA28_16060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NPA28_16065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NPA28_16070	COG1335	isochorismatase
NPA28_16075	COG5506	Protein of unknown function (DUF1694)
NPA28_16090	COG0628	permease
NPA28_16100	COG1418	mRNA catabolic process
NPA28_16105	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_16115	COG1511	domain protein
NPA28_16120	COG1674	ftsk spoiiie
NPA28_16120	COG0433	COG0433 Predicted ATPase
NPA28_16125	COG4499	WXG100 protein secretion system (Wss), protein YukC
NPA28_16130	COG5417	Belongs to the EsaB family
NPA28_16135	COG4842	Belongs to the WXG100 family
NPA28_16140	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NPA28_16140	COG2508	Transcriptional regulator
NPA28_16145	COG0686	Belongs to the AlaDH PNT family
NPA28_16150	COG5634	Uncharacterized conserved protein (DUF2278)
NPA28_16155	COG3251	PFAM MbtH domain protein
NPA28_16160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_16165	COG3433	isochorismatase activity
NPA28_16165	COG1535	isochorismatase
NPA28_16170	COG1021	2,3-dihydroxybenzoate-AMP ligase
NPA28_16175	COG1169	isochorismate synthase
NPA28_16180	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_16185	COG2819	hydrolase of the alpha beta superfamily
NPA28_16190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NPA28_16195	COG1268	BioY protein
NPA28_16200	COG2056	Na+-H+ antiporter family
NPA28_16205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NPA28_16210	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NPA28_16215	COG3584	3D domain protein
NPA28_16230	COG1252	NADH dehydrogenase
NPA28_16235	COG0492	ferredoxin-NADP+ reductase activity
NPA28_16245	COG0516	GMP reductase activity
NPA28_16250	COG0316	Belongs to the HesB IscA family
NPA28_16255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NPA28_16260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NPA28_16265	COG4844	belongs to the
NPA28_16270	COG1252	NADH dehydrogenase
NPA28_16275	COG4837	Protein of unknown function (DUF1462)
NPA28_16280	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NPA28_16285	COG1506	peptidase
NPA28_16285	COG0823	Involved in the tonB-independent uptake of proteins
NPA28_16285	COG4946	Tricorn protease homolog
NPA28_16290	COG0083	homoserine kinase activity
NPA28_16295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NPA28_16300	COG0460	homoserine dehydrogenase
NPA28_16305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NPA28_16310	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NPA28_16315	COG0647	UMP catabolic process
NPA28_16320	COG2445	Protein of unknown function DUF86
NPA28_16325	COG4470	Protein conserved in bacteria
NPA28_16340	COG0739	heme binding
NPA28_16350	COG3377	Domain of unknown function (DUF1805)
NPA28_16355	COG0737	Belongs to the 5'-nucleotidase family
NPA28_16360	COG0730	response to heat
NPA28_16365	COG1801	Protein of unknown function DUF72
NPA28_16375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NPA28_16380	COG2508	Transcriptional regulator
NPA28_16385	COG2233	PERMEase
NPA28_16390	COG2233	PERMEase
NPA28_16395	COG3648	Uricase
NPA28_16395	COG3195	allantoin biosynthetic process
NPA28_16400	COG2351	hydroxyisourate hydrolase activity
NPA28_16415	COG2080	2 iron, 2 sulfur cluster binding
NPA28_16420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NPA28_16425	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NPA28_16430	COG2068	MobA-Related Protein
NPA28_16435	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NPA28_16440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NPA28_16445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NPA28_16450	COG2356	endonuclease I
NPA28_16455	COG3842	ATPase activity
NPA28_16460	COG2188	Transcriptional regulator
NPA28_16465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NPA28_16470	COG0395	ABC-type sugar transport system, permease component
NPA28_16475	COG1175	transmembrane transport
NPA28_16480	COG1653	transport
NPA28_16485	COG2222	sugar isomerase
NPA28_16490	COG0322	excinuclease ABC activity
NPA28_16495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NPA28_16515	COG0719	Fe-S assembly protein
NPA28_16520	COG0822	iron-sulfur transferase activity
NPA28_16525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NPA28_16530	COG0719	Fe-S assembly protein
NPA28_16535	COG0396	ATPase activity
NPA28_16545	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NPA28_16550	COG1464	Belongs to the NlpA lipoprotein family
NPA28_16555	COG2011	ABC-type metal ion transport system permease component
NPA28_16560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NPA28_16570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA28_16575	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NPA28_16585	COG0509	glycine decarboxylation via glycine cleavage system
NPA28_16590	COG1393	Belongs to the ArsC family
NPA28_16595	COG1960	acyl-CoA dehydrogenase activity
NPA28_16600	COG0183	Belongs to the thiolase family
NPA28_16605	COG1024	Enoyl-CoA hydratase
NPA28_16605	COG1250	3-hydroxyacyl-CoA dehydrogenase
NPA28_16615	COG0506	proline dehydrogenase activity
NPA28_16625	COG5577	PFAM Coat F domain
NPA28_16630	COG1846	Transcriptional regulator
NPA28_16635	COG0477	Major facilitator Superfamily
NPA28_16640	COG1942	4-Oxalocrotonate Tautomerase
NPA28_16645	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_16650	COG0583	DNA-binding transcription factor activity
NPA28_16660	COG1120	ATPase activity
NPA28_16675	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_16680	COG0783	Belongs to the Dps family
NPA28_16685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NPA28_16690	COG0745	RESPONSE REGULATOR receiver
NPA28_16695	COG2770	Histidine kinase
NPA28_16695	COG2205	protein histidine kinase activity
NPA28_16705	COG1309	transcriptional regulator
NPA28_16710	COG0114	fumarate hydratase activity
NPA28_16720	COG0697	spore germination
NPA28_16725	COG0814	amino acid
NPA28_16735	COG2197	response regulator
NPA28_16740	COG4585	Histidine kinase
NPA28_16745	COG4758	membrane
NPA28_16750	COG3595	metallopeptidase activity
NPA28_16755	COG1842	Phage shock protein A
NPA28_16760	COG4758	membrane
NPA28_16765	COG2814	Major facilitator Superfamily
NPA28_16770	COG2096	Adenosyltransferase
NPA28_16775	COG1120	ATPase activity
NPA28_16780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA28_16785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA28_16790	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_16795	COG3386	PFAM SMP-30 Gluconolaconase
NPA28_16800	COG2205	protein histidine kinase activity
NPA28_16805	COG0745	RESPONSE REGULATOR receiver
NPA28_16815	COG1191	sigma factor activity
NPA28_16825	COG2140	Oxalate decarboxylase
NPA28_16835	COG0577	efflux transmembrane transporter activity
NPA28_16840	COG1136	(ABC) transporter
NPA28_16845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NPA28_16850	COG1120	ATPase activity
NPA28_16855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA28_16860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA28_16865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA28_16870	COG0531	amino acid
NPA28_16880	COG1988	membrane-bound metal-dependent
NPA28_16885	COG1368	sulfuric ester hydrolase activity
NPA28_16890	COG1910	domain protein
NPA28_16895	COG0725	ABC transporter, periplasmic molybdate-binding protein
NPA28_16900	COG4149	molybdate abc transporter
NPA28_16905	COG0656	L-ascorbic acid biosynthetic process
NPA28_16915	COG0025	NhaP-type Na H and K H
NPA28_16920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NPA28_16925	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NPA28_16930	COG3973	AAA domain
NPA28_16940	COG2860	membrane
NPA28_16945	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NPA28_16950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NPA28_16955	COG2217	Heavy metal translocating P-type atpase
NPA28_16960	COG2217	Heavy metal translocating P-type atpase
NPA28_16965	COG2608	mercury ion transmembrane transporter activity
NPA28_16970	COG1937	Protein conserved in bacteria
NPA28_16975	COG0673	inositol 2-dehydrogenase activity
NPA28_16980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NPA28_16985	COG1289	transmembrane transporter activity
NPA28_16990	COG1802	Transcriptional regulator
NPA28_16995	COG0697	spore germination
NPA28_17005	COG2076	Multidrug Resistance protein
NPA28_17010	COG1309	transcriptional regulator
NPA28_17015	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_17030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NPA28_17035	COG0557	exoribonuclease II activity
NPA28_17040	COG1647	Serine aminopeptidase, S33
NPA28_17045	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NPA28_17050	COG0596	Alpha beta hydrolase
NPA28_17055	COG1476	TRANSCRIPTIONal
NPA28_17060	COG1396	sequence-specific DNA binding
NPA28_17065	COG1396	sequence-specific DNA binding
NPA28_17070	COG1733	regulation of RNA biosynthetic process
NPA28_17075	COG0840	transmembrane signaling receptor activity
NPA28_17080	COG1174	glycine betaine transport
NPA28_17085	COG1732	Glycine betaine
NPA28_17090	COG1174	glycine betaine transport
NPA28_17095	COG1125	glycine betaine transport
NPA28_17095	COG0517	IMP dehydrogenase activity
NPA28_17100	COG1510	regulation of RNA biosynthetic process
NPA28_17105	COG1174	glycine betaine transport
NPA28_17110	COG1732	Glycine betaine
NPA28_17115	COG1174	glycine betaine transport
NPA28_17120	COG1125	glycine betaine transport
NPA28_17120	COG0517	IMP dehydrogenase activity
NPA28_17125	COG1510	regulation of RNA biosynthetic process
NPA28_17135	COG3064	Membrane
NPA28_17140	COG4640	response to antibiotic
NPA28_17145	COG0456	acetyltransferase
NPA28_17160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NPA28_17180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA28_17185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NPA28_17195	COG2234	aminopeptidase activity
NPA28_17205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NPA28_17210	COG0149	triose-phosphate isomerase activity
NPA28_17215	COG0126	phosphoglycerate kinase activity
NPA28_17220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NPA28_17225	COG2390	Transcriptional regulator
NPA28_17230	COG2814	Major facilitator Superfamily
NPA28_17235	COG1609	Transcriptional regulator
NPA28_17240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NPA28_17245	COG0583	DNA-binding transcription factor activity
NPA28_17250	COG0697	spore germination
NPA28_17255	COG1113	amino acid transport
NPA28_17260	COG3858	chitin binding
NPA28_17265	COG1556	Lactate utilization protein
NPA28_17270	COG1139	Iron-sulfur cluster binding protein
NPA28_17275	COG0247	lactate metabolic process
NPA28_17285	COG0596	Alpha beta hydrolase
NPA28_17290	COG2208	phosphoserine phosphatase activity
NPA28_17295	COG3867	Arabinogalactan endo-beta-1,4-galactanase
NPA28_17300	COG1874	Beta-galactosidase
NPA28_17305	COG3833	ABC-type maltose transport systems, permease component
NPA28_17310	COG1175	transmembrane transport
NPA28_17315	COG2182	Extracellular solute-binding protein
NPA28_17320	COG1609	Transcriptional regulator
NPA28_17325	COG2186	Transcriptional regulator
NPA28_17330	COG1620	l-lactate permease
NPA28_17335	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NPA28_17345	COG5039	Polysaccharide pyruvyl transferase
NPA28_17350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NPA28_17355	COG0110	maltose O-acetyltransferase activity
NPA28_17360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NPA28_17365	COG2244	polysaccharide biosynthetic process
NPA28_17370	COG1216	Glycosyl transferase, family 2
NPA28_17375	COG5039	Polysaccharide pyruvyl transferase
NPA28_17380	COG1216	Glycosyl transferase, family 2
NPA28_17390	COG0438	transferase activity, transferring glycosyl groups
NPA28_17395	COG1215	transferase activity, transferring glycosyl groups
NPA28_17400	COG0438	transferase activity, transferring glycosyl groups
NPA28_17405	COG1086	Polysaccharide biosynthesis protein
NPA28_17410	COG0489	protein tyrosine kinase activity
NPA28_17420	COG1396	sequence-specific DNA binding
NPA28_17425	COG2272	Belongs to the type-B carboxylesterase lipase family
NPA28_17435	COG3479	Phenolic acid decarboxylase
NPA28_17445	COG1794	racemase activity, acting on amino acids and derivatives
NPA28_17450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NPA28_17460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NPA28_17465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NPA28_17470	COG0640	Transcriptional regulator
NPA28_17475	COG1621	beta-fructofuranosidase activity
NPA28_17480	COG1621	beta-fructofuranosidase activity
NPA28_17485	COG0531	amino acid
NPA28_17490	COG1309	transcriptional regulator
NPA28_17495	COG2076	Multidrug Resistance protein
NPA28_17500	COG2076	Multidrug Resistance protein
NPA28_17520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NPA28_17525	COG0366	Alpha amylase catalytic
NPA28_17530	COG1554	hydrolase, family 65, central catalytic
NPA28_17535	COG5521	maltodextrose utilization protein MalA
NPA28_17540	COG3833	ABC-type maltose transport systems, permease component
NPA28_17545	COG1175	transmembrane transport
NPA28_17550	COG2182	Extracellular solute-binding protein
NPA28_17560	COG1609	Transcriptional regulator
NPA28_17565	COG1611	Belongs to the LOG family
NPA28_17570	COG1694	Mazg nucleotide pyrophosphohydrolase
NPA28_17575	COG0659	secondary active sulfate transmembrane transporter activity
NPA28_17580	COG0288	reversible hydration of carbon dioxide
NPA28_17585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NPA28_17590	COG0577	efflux transmembrane transporter activity
NPA28_17595	COG1136	(ABC) transporter
NPA28_17600	COG5002	protein histidine kinase activity
NPA28_17605	COG0745	RESPONSE REGULATOR receiver
NPA28_17615	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NPA28_17620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA28_17625	COG1481	regulation of sporulation
NPA28_17630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NPA28_17635	COG1660	Displays ATPase and GTPase activities
NPA28_17640	COG1051	belongs to the nudix hydrolase family
NPA28_17645	COG0492	ferredoxin-NADP+ reductase activity
NPA28_17650	COG0791	NLP P60 protein
NPA28_17650	COG3883	PFAM NLP P60 protein
NPA28_17655	COG0457	Tetratricopeptide repeat
NPA28_17660	COG1132	(ABC) transporter
NPA28_17690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NPA28_17690	COG0140	phosphoribosyl-ATP diphosphatase activity
NPA28_17695	COG0107	imidazoleglycerol-phosphate synthase activity
NPA28_17700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NPA28_17705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NPA28_17710	COG0131	Imidazoleglycerol-phosphate dehydratase
NPA28_17715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NPA28_17720	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NPA28_17725	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NPA28_17730	COG4990	cell redox homeostasis
NPA28_17735	COG5297	Belongs to the glycosyl hydrolase family 6
NPA28_17740	COG0110	maltose O-acetyltransferase activity
NPA28_17745	COG0546	phosphoglycolate phosphatase activity
NPA28_17750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NPA28_17755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NPA28_17760	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NPA28_17765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NPA28_17770	COG0363	glucosamine-6-phosphate deaminase activity
NPA28_17775	COG2188	Transcriptional regulator
NPA28_17780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NPA28_17785	COG1846	Transcriptional regulator
NPA28_17790	COG2814	Major facilitator Superfamily
NPA28_17795	COG1950	PFAM Membrane protein of
NPA28_17800	COG1983	PspC domain protein
NPA28_17805	COG3595	metallopeptidase activity
NPA28_17820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NPA28_17830	COG4897	Protein conserved in bacteria
NPA28_17835	COG3848	Pyruvate phosphate dikinase
NPA28_17835	COG0574	Belongs to the PEP-utilizing enzyme family
NPA28_17840	COG1309	transcriptional regulator
NPA28_17845	COG2814	Major facilitator Superfamily
NPA28_17850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NPA28_17860	COG3409	Peptidoglycan-binding domain 1 protein
NPA28_17860	COG0793	Belongs to the peptidase S41A family
NPA28_17865	COG2177	Part of the ABC transporter FtsEX involved in
NPA28_17870	COG2884	Cell division ATP-binding protein ftsE
NPA28_17875	COG2010	Cytochrome c
NPA28_17880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA28_17890	COG0653	protein targeting
NPA28_17895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NPA28_17910	COG1516	flagellar protein fliS
NPA28_17915	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NPA28_17920	COG1334	flagellar protein FlaG
NPA28_17925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NPA28_17930	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NPA28_17935	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
NPA28_17945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NPA28_17950	COG4786	Flagellar basal body rod
NPA28_17950	COG1256	bacterial-type flagellum assembly
NPA28_17955	COG3418	PFAM FlgN family protein
NPA28_17960	COG2747	anti-sigma28 factor FlgM
NPA28_17970	COG1040	competence protein
NPA28_17980	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NPA28_17985	COG1307	EDD domain protein, DegV family
NPA28_17990	COG2197	response regulator
NPA28_17995	COG4585	Histidine kinase
NPA28_18000	COG1739	Uncharacterized protein family UPF0029
NPA28_18005	COG1316	TRANSCRIPTIONal
NPA28_18010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NPA28_18015	COG0438	transferase activity, transferring glycosyl groups
NPA28_18020	COG1215	transferase activity, transferring glycosyl groups
NPA28_18025	COG3206	protein involved in exopolysaccharide biosynthesis
NPA28_18030	COG3307	-O-antigen
NPA28_18035	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NPA28_18040	COG0438	transferase activity, transferring glycosyl groups
NPA28_18040	COG0297	glycogen (starch) synthase activity
NPA28_18045	COG2244	polysaccharide biosynthetic process
NPA28_18055	COG2247	cell wall binding repeat
NPA28_18055	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPA28_18060	COG2385	sporulation resulting in formation of a cellular spore
NPA28_18060	COG2247	cell wall binding repeat
NPA28_18070	COG1316	TRANSCRIPTIONal
NPA28_18075	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NPA28_18080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NPA28_18095	COG0438	transferase activity, transferring glycosyl groups
NPA28_18100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NPA28_18125	COG1134	teichoic acid transport
NPA28_18130	COG1682	transport, permease protein
NPA28_18135	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NPA28_18140	COG0438	transferase activity, transferring glycosyl groups
NPA28_18145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NPA28_18150	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NPA28_18155	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NPA28_18165	COG4193	domain, Protein
NPA28_18170	COG1482	cell wall glycoprotein biosynthetic process
NPA28_18175	COG0697	spore germination
NPA28_18180	COG0814	amino acid
NPA28_18190	COG2814	Major facilitator Superfamily
NPA28_18195	COG1316	TRANSCRIPTIONal
NPA28_18200	COG0561	phosphatase activity
NPA28_18205	COG0791	NLP P60 protein
NPA28_18215	COG2843	Capsule synthesis protein
NPA28_18225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NPA28_18230	COG1609	Transcriptional regulator
NPA28_18235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NPA28_18240	COG1869	D-ribose catabolic process
NPA28_18245	COG1129	ABC transporter
NPA28_18250	COG1172	Belongs to the binding-protein-dependent transport system permease family
NPA28_18255	COG1879	ABC-type sugar transport system periplasmic component
NPA28_18260	COG3103	Sh3 type 3 domain protein
NPA28_18270	COG2249	NAD(P)H dehydrogenase (quinone) activity
NPA28_18275	COG3527	Alpha-acetolactate decarboxylase
NPA28_18280	COG0028	Belongs to the TPP enzyme family
NPA28_18285	COG0583	DNA-binding transcription factor activity
NPA28_18290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NPA28_18305	COG5337	Spore coat protein CotH
NPA28_18315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NPA28_18320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA28_18335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NPA28_18345	COG0405	Gamma-glutamyltransferase
NPA28_18350	COG1522	sequence-specific DNA binding
NPA28_18355	COG2059	Chromate
NPA28_18360	COG2059	Chromate
NPA28_18370	COG0655	NAD(P)H dehydrogenase (quinone) activity
NPA28_18375	COG0583	DNA-binding transcription factor activity
NPA28_18425	COG5444	nuclease activity
NPA28_18445	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NPA28_18450	COG4464	protein tyrosine phosphatase activity
NPA28_18455	COG0489	protein tyrosine kinase activity
NPA28_18460	COG3944	biosynthesis protein
NPA28_18470	COG4715	Zinc finger, swim domain protein
NPA28_18475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NPA28_18480	COG0561	phosphatase activity
NPA28_18485	COG1349	DNA-binding transcription factor activity
NPA28_18490	COG0629	single-stranded DNA binding
NPA28_18505	COG2602	Beta-lactamase
NPA28_18510	COG1970	mechanosensitive ion channel activity
NPA28_18515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NPA28_18520	COG0457	Tetratricopeptide repeat
NPA28_18525	COG4786	Flagellar basal body rod
NPA28_18530	COG4786	Flagellar basal body rod
NPA28_18535	COG1077	Cell shape determining protein MreB Mrl
NPA28_18540	COG1609	Transcriptional regulator
NPA28_18550	COG1846	Transcriptional regulator
NPA28_18555	COG2814	Major facilitator Superfamily
NPA28_18560	COG3420	alginic acid biosynthetic process
NPA28_18565	COG1953	Uracil, thiamine, allantoin
NPA28_18570	COG0477	Major facilitator Superfamily
NPA28_18575	COG1335	isochorismatase
NPA28_18585	COG0004	ammonium transporteR
NPA28_18590	COG0347	Belongs to the P(II) protein family
NPA28_18595	COG0671	phosphoesterase, PA-phosphatase related
NPA28_18605	COG0739	heme binding
NPA28_18610	COG1247	-acetyltransferase
NPA28_18620	COG1086	Polysaccharide biosynthesis protein
NPA28_18625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA28_18630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NPA28_18635	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NPA28_18650	COG2089	acid synthase
NPA28_18660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NPA28_18670	COG2910	NAD(P)H-binding
NPA28_18675	COG1959	2 iron, 2 sulfur cluster binding
NPA28_18680	COG0804	urea catabolic process
NPA28_18685	COG0832	Belongs to the urease beta subunit family
NPA28_18690	COG0831	urea catabolic process
NPA28_18720	COG3237	CsbD-like
NPA28_18725	COG1994	Peptidase M50
NPA28_18730	COG0457	Tetratricopeptide repeat
NPA28_18735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NPA28_18740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NPA28_18750	COG2304	oxidoreductase activity
NPA28_18755	COG2304	oxidoreductase activity
NPA28_18760	COG2385	sporulation resulting in formation of a cellular spore
NPA28_18765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NPA28_18775	COG4836	Membrane
NPA28_18785	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NPA28_18790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NPA28_18795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NPA28_18805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NPA28_18810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NPA28_18820	COG0356	it plays a direct role in the translocation of protons across the membrane
NPA28_18830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NPA28_18835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NPA28_18840	COG4475	Protein of unknown function (DUF436)
NPA28_18845	COG0698	ribose 5-phosphate isomerase
NPA28_18850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NPA28_18855	COG1971	Probably functions as a manganese efflux pump
NPA28_18860	COG0009	L-threonylcarbamoyladenylate synthase
NPA28_18865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NPA28_18885	COG2890	protein-(glutamine-N5) methyltransferase activity
NPA28_18890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NPA28_18895	COG0346	lactoylglutathione lyase activity
NPA28_18900	COG0789	Transcriptional regulator
NPA28_18905	COG0679	Auxin Efflux Carrier
NPA28_18910	COG0281	malic enzyme
NPA28_18915	COG1435	thymidine kinase activity
NPA28_18925	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NPA28_18935	COG1494	fructose-1,6-bisphosphatase
NPA28_18940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NPA28_18945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NPA28_18950	COG0191	fructose-bisphosphate aldolase activity
NPA28_18955	COG2204	response regulator
NPA28_18960	COG4821	SIS domain
NPA28_18965	COG0504	CTP synthase activity
NPA28_18970	COG3343	RNA polymerase activity
NPA28_18975	COG1960	acyl-CoA dehydrogenase activity
NPA28_18980	COG0247	lactate metabolic process
NPA28_18980	COG2181	nitrate reductase activity
NPA28_18985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NPA28_18990	COG4294	response to UV
NPA28_19000	COG1476	TRANSCRIPTIONal
NPA28_19010	COG1132	(ABC) transporter
NPA28_19015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NPA28_19025	COG2181	nitrate reductase activity
NPA28_19030	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NPA28_19035	COG1140	nitrate reductase beta subunit
NPA28_19040	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NPA28_19045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NPA28_19055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NPA28_19060	COG2223	nitrite transmembrane transporter activity
NPA28_19065	COG0018	arginyl-trna synthetase
NPA28_19070	COG4506	Protein conserved in bacteria
NPA28_19085	COG0535	radical SAM domain protein
NPA28_19095	COG1131	(ABC) transporter
NPA28_19105	COG0612	Peptidase, M16
NPA28_19125	COG3391	amine dehydrogenase activity
NPA28_19130	COG0457	Tetratricopeptide repeat
NPA28_19140	COG0010	Belongs to the arginase family
NPA28_19145	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NPA28_19150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NPA28_19165	COG1994	Peptidase M50
NPA28_19170	COG1942	4-Oxalocrotonate Tautomerase
NPA28_19175	COG1846	Transcriptional regulator
NPA28_19180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NPA28_19190	COG0477	Major facilitator Superfamily
NPA28_19195	COG1959	2 iron, 2 sulfur cluster binding
NPA28_19200	COG3465	dGTPase activity
NPA28_19205	COG1078	dGTPase activity
NPA28_19210	COG4844	belongs to the
NPA28_19220	COG0697	spore germination
NPA28_19225	COG0095	Lipoate-protein ligase
NPA28_19230	COG0583	DNA-binding transcription factor activity
NPA28_19235	COG0280	phosphate acetyltransferase
NPA28_19240	COG3253	May function as heme-dependent peroxidase
NPA28_19245	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_19250	COG0436	Aminotransferase
NPA28_19255	COG2814	Major facilitator Superfamily
NPA28_19260	COG0151	Belongs to the GarS family
NPA28_19265	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_19270	COG1917	Cupin 2, conserved barrel domain protein
NPA28_19275	COG0077	Prephenate dehydratase
NPA28_19280	COG2814	Major facilitator Superfamily
NPA28_19285	COG2814	Major facilitator Superfamily
NPA28_19290	COG0833	amino acid
NPA28_19295	COG4187	Peptidase family M20/M25/M40
NPA28_19300	COG1012	belongs to the aldehyde dehydrogenase family
NPA28_19305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NPA28_19315	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NPA28_19320	COG1091	dTDP-4-dehydrorhamnose reductase activity
NPA28_19325	COG1088	dTDP-glucose 4,6-dehydratase activity
NPA28_19330	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NPA28_19335	COG3980	spore coat polysaccharide biosynthesis protein
NPA28_19340	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NPA28_19345	COG2089	acid synthase
NPA28_19350	COG0456	acetyltransferase
NPA28_19355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NPA28_19360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NPA28_19365	COG0463	Glycosyl transferase, family 2
NPA28_19375	COG2363	Small membrane protein
NPA28_19380	COG2233	PERMEase
NPA28_19390	COG1012	belongs to the aldehyde dehydrogenase family
NPA28_19395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NPA28_19400	COG1216	Glycosyl transferase, family 2
NPA28_19415	COG1695	Transcriptional regulator
NPA28_19420	COG0351	phosphomethylpyrimidine kinase
NPA28_19430	COG1621	beta-fructofuranosidase activity
NPA28_19435	COG1263	PTS System
NPA28_19435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA28_19440	COG2116	formate transmembrane transporter activity
NPA28_19445	COG3711	transcriptional antiterminator
NPA28_19455	COG1404	Belongs to the peptidase S8 family
NPA28_19460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NPA28_19465	COG0778	Nitroreductase
NPA28_19470	COG0772	Belongs to the SEDS family
NPA28_19495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NPA28_19500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NPA28_19505	COG2261	transglycosylase associated protein
NPA28_19510	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NPA28_19515	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NPA28_19520	COG2246	polysaccharide biosynthetic process
NPA28_19525	COG1309	transcriptional regulator
NPA28_19535	COG3162	membrane
NPA28_19540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NPA28_19545	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NPA28_19550	COG2837	iron assimilation
NPA28_19555	COG2822	iron ion transport
NPA28_19560	COG0672	)-iron permease
NPA28_19565	COG0352	thiamine-phosphate diphosphorylase activity
NPA28_19570	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NPA28_19575	COG0583	DNA-binding transcription factor activity
NPA28_19580	COG1380	Effector of murein hydrolase LrgA
NPA28_19585	COG1346	cytolysis
NPA28_19590	COG2814	Major facilitator Superfamily
NPA28_19595	COG4895	conserved protein (DUF2196)
NPA28_19600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NPA28_19605	COG0346	lactoylglutathione lyase activity
NPA28_19615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPA28_19620	COG1404	Belongs to the peptidase S8 family
NPA28_19625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA28_19625	COG1263	PTS System
NPA28_19630	COG3711	transcriptional antiterminator
NPA28_19635	COG1442	glycosyl transferase family 8
NPA28_19640	COG5522	Integral membrane protein (intg_mem_TP0381)
NPA28_19645	COG1846	Transcriptional regulator
NPA28_19650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NPA28_19655	COG2234	aminopeptidase activity
NPA28_19670	COG2814	Major facilitator Superfamily
NPA28_19675	COG2357	RelA SpoT domain protein
NPA28_19680	COG1575	Belongs to the MenA family. Type 1 subfamily
NPA28_19690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA28_19695	COG1696	Membrane protein involved in D-alanine export
NPA28_19700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA28_19705	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NPA28_19710	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NPA28_19715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NPA28_19720	COG1486	melibiose metabolic process
NPA28_19725	COG1447	Phosphotransferase system cellobiose-specific component IIA
NPA28_19730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPA28_19735	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPA28_19740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA28_19740	COG3711	transcriptional antiterminator
NPA28_19750	COG2094	Belongs to the DNA glycosylase MPG family
NPA28_19755	COG0753	catalase activity
NPA28_19760	COG2814	Major facilitator Superfamily
NPA28_19765	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NPA28_19770	COG1131	(ABC) transporter
NPA28_19790	COG1595	DNA-templated transcription, initiation
NPA28_19795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NPA28_19800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NPA28_19805	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NPA28_19810	COG4988	ABC transporter
NPA28_19815	COG1294	oxidase, subunit
NPA28_19820	COG1271	oxidase subunit
NPA28_19825	COG3493	citrate carrier protein
NPA28_19830	COG0501	Belongs to the peptidase M48B family
NPA28_19840	COG0726	polysaccharide deacetylase
NPA28_19850	COG3842	ATPase activity
NPA28_19855	COG2508	Transcriptional regulator
NPA28_19860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA28_19870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NPA28_19875	COG1881	PFAM PEBP family protein
NPA28_19880	COG0583	DNA-binding transcription factor activity
NPA28_19895	COG2195	Cleaves the N-terminal amino acid of tripeptides
NPA28_19910	COG4894	glucomannan catabolic process
NPA28_19915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NPA28_19920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NPA28_19925	COG3829	transcription factor binding
NPA28_19925	COG3290	protein histidine kinase activity
NPA28_19930	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_19935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NPA28_19940	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NPA28_19945	COG2610	gluconate transmembrane transporter activity
NPA28_19950	COG0500	methyltransferase
NPA28_19955	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_19960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NPA28_19975	COG0693	protein deglycase activity
NPA28_19975	COG0753	catalase activity
NPA28_19980	COG2851	Citrate transporter
NPA28_19990	COG2723	6-phospho-beta-galactosidase activity
NPA28_19995	COG1263	PTS System
NPA28_19995	COG2190	(PTS) system
NPA28_19995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA28_20000	COG3711	transcriptional antiterminator
NPA28_20010	COG2270	Major facilitator Superfamily
NPA28_20015	COG0513	Belongs to the DEAD box helicase family
NPA28_20020	COG2755	lipolytic protein G-D-S-L family
NPA28_20020	COG3401	FG-GAP repeat protein
NPA28_20100	COG0697	spore germination
NPA28_20105	COG0589	response to stress
NPA28_20110	COG2723	6-phospho-beta-galactosidase activity
NPA28_20115	COG1263	PTS System
NPA28_20115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA28_20115	COG2190	(PTS) system
NPA28_20145	COG5444	nuclease activity
NPA28_20160	COG3507	Belongs to the glycosyl hydrolase 43 family
NPA28_20175	COG2986	histidine ammonia-lyase
NPA28_20180	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NPA28_20185	COG1228	amidohydrolase
NPA28_20190	COG0010	Belongs to the arginase family
NPA28_20195	COG0833	amino acid
NPA28_20200	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NPA28_20205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NPA28_20210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NPA28_20215	COG2390	Transcriptional regulator
NPA28_20245	COG1131	(ABC) transporter
NPA28_20270	COG2079	MmgE PrpD family protein
NPA28_20275	COG1473	amidohydrolase
NPA28_20280	COG1126	abc transporter atp-binding protein
NPA28_20285	COG0765	amino acid transport
NPA28_20290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA28_20295	COG0456	acetyltransferase
NPA28_20300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NPA28_20310	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
NPA28_20315	COG0561	phosphatase activity
NPA28_20345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA28_20350	COG5294	Protein conserved in bacteria
NPA28_20355	COG0577	efflux transmembrane transporter activity
NPA28_20360	COG1136	(ABC) transporter
NPA28_20365	COG2205	protein histidine kinase activity
NPA28_20370	COG0745	RESPONSE REGULATOR receiver
NPA28_20375	COG0191	fructose-bisphosphate aldolase activity
NPA28_20385	COG1082	Xylose isomerase domain protein TIM barrel
NPA28_20390	COG0673	inositol 2-dehydrogenase activity
NPA28_20395	COG2814	Major facilitator Superfamily
NPA28_20400	COG1082	Xylose isomerase domain protein TIM barrel
NPA28_20405	COG3962	Belongs to the TPP enzyme family
NPA28_20410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NPA28_20420	COG1012	belongs to the aldehyde dehydrogenase family
NPA28_20425	COG1349	DNA-binding transcription factor activity
NPA28_20430	COG0667	Aldo Keto reductase
NPA28_20455	COG2814	Major facilitator Superfamily
NPA28_20460	COG0326	Molecular chaperone. Has ATPase activity
NPA28_20470	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_20475	COG1309	transcriptional regulator
NPA28_20480	COG1012	belongs to the aldehyde dehydrogenase family
NPA28_20485	COG1714	RDD family
NPA28_20490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NPA28_20500	COG1714	RDD family
NPA28_20505	COG2311	Membrane
NPA28_20510	COG1917	Cupin 2, conserved barrel domain protein
NPA28_20515	COG1309	transcriptional regulator
NPA28_20520	COG1028	Short-chain dehydrogenase reductase Sdr
NPA28_20550	COG5039	Polysaccharide pyruvyl transferase
NPA28_20555	COG1929	Belongs to the glycerate kinase type-1 family
NPA28_20560	COG1802	Transcriptional regulator
NPA28_20565	COG1070	Carbohydrate kinase
NPA28_20570	COG2610	gluconate transmembrane transporter activity
NPA28_20575	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NPA28_20580	COG0450	alkyl hydroperoxide reductase
NPA28_20585	COG3634	alkyl hydroperoxide reductase activity
NPA28_20600	COG1113	amino acid transport
NPA28_20605	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
NPA28_20615	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NPA28_20630	COG1063	alcohol dehydrogenase
NPA28_20650	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
NPA28_20660	COG0457	Tetratricopeptide repeat
NPA28_20670	COG0010	Belongs to the arginase family
NPA28_20675	COG0833	amino acid
NPA28_20680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NPA28_20685	COG3829	transcription factor binding
NPA28_20690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NPA28_20695	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NPA28_20700	COG4853	Protein conserved in bacteria
NPA28_20705	COG4863	YycH protein
NPA28_20710	COG5002	protein histidine kinase activity
NPA28_20715	COG0745	RESPONSE REGULATOR receiver
NPA28_20745	COG0346	lactoylglutathione lyase activity
NPA28_20750	COG0305	Participates in initiation and elongation during chromosome replication
NPA28_20765	COG3093	addiction module antidote protein HigA
NPA28_20770	COG2807	transmembrane transport
NPA28_20775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NPA28_20780	COG0359	binds to the 23S rRNA
NPA28_20785	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NPA28_20790	COG4241	membrane
NPA28_20800	COG5577	PFAM Coat F domain
NPA28_20805	COG1733	regulation of RNA biosynthetic process
NPA28_20810	COG1227	inorganic diphosphatase activity
NPA28_20820	COG2271	Major facilitator Superfamily
NPA28_20825	COG0789	Transcriptional regulator
NPA28_20825	COG4978	Transcriptional regulator
NPA28_20840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPA28_20850	COG0640	Transcriptional regulator
NPA28_20855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NPA28_20860	COG2409	Drug exporters of the RND superfamily
NPA28_20865	COG2197	response regulator
NPA28_20870	COG4585	Histidine kinase
NPA28_20885	COG0789	Transcriptional regulator
NPA28_20885	COG4978	Transcriptional regulator
NPA28_20890	COG1811	Na channel or pump
NPA28_20905	COG0789	Transcriptional regulator
NPA28_20910	COG0697	spore germination
NPA28_20915	COG1331	Highly conserved protein containing a thioredoxin domain
NPA28_20920	COG1266	CAAX protease self-immunity
NPA28_20925	COG0477	Major facilitator Superfamily
NPA28_20925	COG2814	Major facilitator Superfamily
NPA28_20930	COG0110	maltose O-acetyltransferase activity
NPA28_20935	COG0346	lactoylglutathione lyase activity
NPA28_20940	COG1609	Transcriptional regulator
NPA28_20945	COG0708	Exodeoxyribonuclease III
NPA28_20955	COG0629	single-stranded DNA binding
NPA28_20960	COG0360	Binds together with S18 to 16S ribosomal RNA
NPA28_20965	COG0012	GTP binding
NPA28_20970	COG0243	molybdopterin cofactor binding
NPA28_20975	COG4481	Protein conserved in bacteria
NPA28_20980	COG3949	Membrane
NPA28_20990	COG1475	DNA binding
NPA28_20995	COG1192	Involved in chromosome partitioning
NPA28_21005	COG1475	DNA binding
NPA28_21010	COG0357	Ribosomal RNA small subunit methyltransferase G
NPA28_21015	COG0445	tRNA wobble uridine modification
NPA28_21020	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NPA28_21025	COG1847	R3H domain protein
NPA28_21030	COG0706	membrane insertase activity
NPA28_21035	COG0594	ribonuclease P activity