locus-tag	class	description
B4U37_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B4U37_00010	COG0592	DNA-directed DNA polymerase activity
B4U37_00015	COG2501	S4 domain
B4U37_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4U37_00030	COG0187	DNA topoisomerase II activity
B4U37_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4U37_00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B4U37_00075	COG0516	GMP reductase activity
B4U37_00075	COG0517	IMP dehydrogenase activity
B4U37_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B4U37_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B4U37_00105	COG1428	Deoxynucleoside kinase
B4U37_00110	COG1428	Deoxynucleoside kinase
B4U37_00115	COG1388	LysM domain
B4U37_00115	COG3858	chitin binding
B4U37_00120	COG1335	isochorismatase
B4U37_00125	COG0590	tRNA wobble adenosine to inosine editing
B4U37_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4U37_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B4U37_00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B4U37_00180	COG1982	Orn Lys Arg decarboxylase major
B4U37_00190	COG3870	Protein conserved in bacteria
B4U37_00195	COG1728	Protein conserved in bacteria
B4U37_00200	COG0470	DNA polymerase III
B4U37_00205	COG1774	PSP1 C-terminal conserved region
B4U37_00210	COG4467	Involved in initiation control of chromosome replication
B4U37_00215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B4U37_00220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B4U37_00225	COG2002	toxin-antitoxin pair type II binding
B4U37_00235	COG0084	hydrolase, TatD family'
B4U37_00240	COG3583	domain protein
B4U37_00240	COG3584	3D domain protein
B4U37_00250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B4U37_00260	COG4466	Protein conserved in bacteria
B4U37_00270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B4U37_00275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4U37_00280	COG0251	oxidation-reduction process
B4U37_00290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B4U37_00295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B4U37_00300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B4U37_00315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4U37_00320	COG2002	toxin-antitoxin pair type II binding
B4U37_00325	COG2244	polysaccharide biosynthetic process
B4U37_00330	COG3956	TIGRFAM MazG family protein
B4U37_00335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4U37_00350	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B4U37_00355	COG1098	S1 RNA binding domain
B4U37_00375	COG2208	phosphoserine phosphatase activity
B4U37_00385	COG2304	oxidoreductase activity
B4U37_00390	COG0515	serine threonine protein kinase
B4U37_00405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4U37_00410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B4U37_00415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B4U37_00420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4U37_00425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U37_00430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4U37_00435	COG0512	Glutamine amidotransferase of anthranilate synthase
B4U37_00440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4U37_00445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4U37_00450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4U37_00455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4U37_00460	COG1396	sequence-specific DNA binding
B4U37_00465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4U37_00470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4U37_00505	COG3880	PFAM UvrB UvrC protein
B4U37_00510	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B4U37_00515	COG0542	response to heat
B4U37_00520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B4U37_00530	COG4956	integral membrane protein (PIN domain superfamily)
B4U37_00535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B4U37_00540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B4U37_00550	COG1045	serine acetyltransferase
B4U37_00555	COG0215	cysteine-tRNA ligase activity
B4U37_00565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4U37_00570	COG3688	RNA-binding protein containing a PIN domain
B4U37_00580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B4U37_00585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4U37_00590	COG0250	Participates in transcription elongation, termination and antitermination
B4U37_00600	COG0081	regulation of translation
B4U37_00605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B4U37_00615	COG2813	Specifically methylates the guanine in position
B4U37_00620	COG0085	RNA polymerase activity
B4U37_00625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B4U37_00630	COG1358	cellular component organization or biogenesis
B4U37_00635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B4U37_00640	COG0049	tRNA binding
B4U37_00645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B4U37_00650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B4U37_00655	COG0051	transcription antitermination factor activity, RNA binding
B4U37_00660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B4U37_00665	COG0088	Forms part of the polypeptide exit tunnel
B4U37_00670	COG0089	rRNA binding
B4U37_00675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B4U37_00680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B4U37_00685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B4U37_00690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B4U37_00695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B4U37_00700	COG0255	Belongs to the universal ribosomal protein uL29 family
B4U37_00705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B4U37_00710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B4U37_00715	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B4U37_00725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4U37_00730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B4U37_00735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B4U37_00745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B4U37_00750	COG1841	ribosomal large subunit assembly
B4U37_00755	COG0200	Binds to the 23S rRNA
B4U37_00760	COG0201	protein transport
B4U37_00765	COG0563	adenylate kinase activity
B4U37_00770	COG0024	Methionine aminopeptidase
B4U37_00780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B4U37_00785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B4U37_00790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B4U37_00805	COG0203	ribosomal protein L17
B4U37_00810	COG1122	ATPase activity
B4U37_00815	COG1122	ATPase activity
B4U37_00820	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4U37_00825	COG0101	tRNA pseudouridine synthase activity
B4U37_00830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B4U37_00835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B4U37_00860	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_00865	COG0489	protein tyrosine kinase activity
B4U37_00875	COG2194	sulfuric ester hydrolase activity
B4U37_00880	COG0726	polysaccharide deacetylase
B4U37_00955	COG1595	DNA-templated transcription, initiation
B4U37_00960	COG5662	AntiSigma factor
B4U37_00965	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4U37_00970	COG4856	YbbR-like protein
B4U37_00975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U37_00990	COG0531	amino acid
B4U37_00995	COG0697	spore germination
B4U37_01005	COG1114	Component of the transport system for branched-chain amino acids
B4U37_01010	COG1802	Transcriptional regulator
B4U37_01020	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B4U37_01040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B4U37_01045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4U37_01050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4U37_01085	COG0840	transmembrane signaling receptor activity
B4U37_01100	COG5577	PFAM Coat F domain
B4U37_01110	COG0393	Putative heavy-metal-binding
B4U37_01115	COG1649	PFAM Uncharacterised BCR, COG1649
B4U37_01120	COG0789	Transcriptional regulator
B4U37_01125	COG1253	flavin adenine dinucleotide binding
B4U37_01130	COG4536	flavin adenine dinucleotide binding
B4U37_01135	COG0772	Belongs to the SEDS family
B4U37_01165	COG1695	Transcriptional regulator
B4U37_01175	COG4585	Histidine kinase
B4U37_01185	COG1131	(ABC) transporter
B4U37_01210	COG0840	transmembrane signaling receptor activity
B4U37_01215	COG1595	DNA-templated transcription, initiation
B4U37_01225	COG3942	CHAP domain
B4U37_01225	COG1388	LysM domain
B4U37_01230	COG1410	methionine synthase
B4U37_01230	COG0646	methionine synthase
B4U37_01235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B4U37_01235	COG0646	methionine synthase
B4U37_01240	COG0626	cystathionine gamma-synthase activity
B4U37_01245	COG0626	cystathionine gamma-synthase activity
B4U37_01250	COG4988	ABC transporter
B4U37_01255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4U37_01265	COG1132	(ABC) transporter
B4U37_01275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U37_01275	COG0723	plastoquinol--plastocyanin reductase activity
B4U37_01290	COG4134	Bacterial extracellular solute-binding protein
B4U37_01305	COG3842	ATPase activity
B4U37_01310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4U37_01310	COG1213	nucleotidyl transferase
B4U37_01315	COG3237	CsbD-like
B4U37_01325	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_01335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B4U37_01340	COG3973	AAA domain
B4U37_01355	COG1937	Protein conserved in bacteria
B4U37_01360	COG2608	mercury ion transmembrane transporter activity
B4U37_01365	COG2217	Heavy metal translocating P-type atpase
B4U37_01385	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U37_01395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4U37_01400	COG0513	Belongs to the DEAD box helicase family
B4U37_01405	COG4294	response to UV
B4U37_01410	COG3402	PFAM membrane-flanked domain
B4U37_01415	COG3428	Bacterial PH domain
B4U37_01420	COG0705	Rhomboid family
B4U37_01425	COG0736	holo-[acyl-carrier-protein] synthase activity
B4U37_01430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B4U37_01440	COG0864	Transcriptional regulator
B4U37_01445	COG2337	Toxic component of a toxin-antitoxin (TA) module
B4U37_01450	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_01455	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_01460	COG2172	sigma factor antagonist activity
B4U37_01465	COG2208	phosphoserine phosphatase activity
B4U37_01470	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_01475	COG2172	sigma factor antagonist activity
B4U37_01480	COG1191	sigma factor activity
B4U37_01485	COG2208	phosphoserine phosphatase activity
B4U37_01490	COG2183	response to ionizing radiation
B4U37_01590	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B4U37_01595	COG0802	atpase or kinase
B4U37_01600	COG1214	PFAM Peptidase M22, glycoprotease
B4U37_01605	COG0456	acetyltransferase
B4U37_01620	COG1131	(ABC) transporter
B4U37_01635	COG0488	(ABC) transporter
B4U37_01640	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B4U37_01645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4U37_01650	COG0805	protein transport
B4U37_01665	COG1266	CAAX protease self-immunity
B4U37_01670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B4U37_01675	COG0459	protein refolding
B4U37_01680	COG0582	viral genome integration into host DNA
B4U37_01750	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4U37_01780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4U37_01785	COG1136	(ABC) transporter
B4U37_01790	COG0577	efflux transmembrane transporter activity
B4U37_01805	COG5002	protein histidine kinase activity
B4U37_01855	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_01990	COG0697	spore germination
B4U37_02000	COG0300	oxidoreductase activity
B4U37_02005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B4U37_02010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B4U37_02015	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4U37_02020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4U37_02030	COG1733	regulation of RNA biosynthetic process
B4U37_02040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U37_02045	COG0482	sulfurtransferase activity
B4U37_02070	COG1525	nuclease
B4U37_02080	COG0598	Magnesium transport protein CorA
B4U37_02085	COG2182	Extracellular solute-binding protein
B4U37_02090	COG1609	Transcriptional regulator
B4U37_02105	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_02115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B4U37_02120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4U37_02125	COG3328	transposase activity
B4U37_02135	COG1278	Cold shock
B4U37_02140	COG1329	Transcriptional regulator
B4U37_02150	COG5002	protein histidine kinase activity
B4U37_02150	COG3850	Histidine kinase
B4U37_02155	COG1136	(ABC) transporter
B4U37_02160	COG0577	efflux transmembrane transporter activity
B4U37_02170	COG2172	sigma factor antagonist activity
B4U37_02180	COG0714	Associated with various cellular activities
B4U37_02185	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B4U37_02190	COG1305	Transglutaminase-like
B4U37_02195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B4U37_02195	COG0519	Catalyzes the synthesis of GMP from XMP
B4U37_02200	COG2252	PERMEase
B4U37_02225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4U37_02230	COG1131	(ABC) transporter
B4U37_02250	COG1595	DNA-templated transcription, initiation
B4U37_02265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4U37_02270	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B4U37_02280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B4U37_02285	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B4U37_02290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4U37_02300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B4U37_02305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4U37_02310	COG0047	phosphoribosylformylglycinamidine synthase activity
B4U37_02320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B4U37_02330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B4U37_02335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4U37_02345	COG0151	Belongs to the GarS family
B4U37_02355	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B4U37_02360	COG1470	cell adhesion involved in biofilm formation
B4U37_02365	COG4496	protein, YerC YecD
B4U37_02370	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B4U37_02375	COG0210	DNA helicase
B4U37_02385	COG4851	CamS sex pheromone cAM373 precursor
B4U37_02405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U37_02410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4U37_02415	COG0154	amidase activity
B4U37_02425	COG1876	peptidase activity
B4U37_02430	COG1585	Membrane protein implicated in regulation of membrane protease activity
B4U37_02435	COG2268	Band 7 protein
B4U37_02440	COG1597	lipid kinase activity
B4U37_02460	COG0306	phosphate transporter
B4U37_02465	COG2046	Belongs to the sulfate adenylyltransferase family
B4U37_02470	COG0529	Catalyzes the synthesis of activated sulfate
B4U37_02475	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4U37_02490	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B4U37_02510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4U37_02515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B4U37_02535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4U37_02540	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B4U37_02545	COG1349	DNA-binding transcription factor activity
B4U37_02560	COG0561	phosphatase activity
B4U37_02565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_02575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_02590	COG3328	transposase activity
B4U37_02595	COG2233	PERMEase
B4U37_02600	COG0583	DNA-binding transcription factor activity
B4U37_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_02660	COG3708	Transcriptional regulator
B4U37_02660	COG2207	Transcriptional regulator
B4U37_02710	COG1595	DNA-templated transcription, initiation
B4U37_02735	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_02740	COG0456	acetyltransferase
B4U37_02740	COG1846	Transcriptional regulator
B4U37_02745	COG0601	transmembrane transport
B4U37_02780	COG3546	catalase activity
B4U37_02785	COG1263	PTS System
B4U37_02785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U37_02785	COG2190	(PTS) system
B4U37_02810	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4U37_02830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B4U37_02835	COG1113	amino acid transport
B4U37_02840	COG2814	Major facilitator Superfamily
B4U37_02850	COG1280	lysine exporter protein (LysE YggA)
B4U37_02860	COG1834	amidinotransferase
B4U37_02875	COG0778	Nitroreductase
B4U37_02935	COG3655	Transcriptional regulator
B4U37_02955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4U37_02995	COG0210	DNA helicase
B4U37_03000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4U37_03005	COG3344	reverse transcriptase
B4U37_03010	COG0583	DNA-binding transcription factor activity
B4U37_03040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_03075	COG3340	Belongs to the peptidase S51 family
B4U37_03090	COG3615	Tellurite resistance protein tehB
B4U37_03090	COG0500	methyltransferase
B4U37_03125	COG2814	Major facilitator Superfamily
B4U37_03130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4U37_03135	COG2814	Major facilitator Superfamily
B4U37_03140	COG0300	oxidoreductase activity
B4U37_03160	COG1595	DNA-templated transcription, initiation
B4U37_03170	COG1247	-acetyltransferase
B4U37_03190	COG2226	methyltransferase
B4U37_03195	COG2124	cytochrome p450
B4U37_03275	COG1404	Belongs to the peptidase S8 family
B4U37_03300	COG1968	undecaprenyl-diphosphatase activity
B4U37_03315	COG0785	Cytochrome C biogenesis protein
B4U37_03335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_03340	COG2318	DinB family
B4U37_03345	COG1794	racemase activity, acting on amino acids and derivatives
B4U37_03365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_03370	COG1063	alcohol dehydrogenase
B4U37_03395	COG1476	TRANSCRIPTIONal
B4U37_03415	COG0456	acetyltransferase
B4U37_03415	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B4U37_03455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_03485	COG0328	RNA-DNA hybrid ribonuclease activity
B4U37_03485	COG3341	Caulimovirus viroplasmin
B4U37_03540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_03555	COG0488	(ABC) transporter
B4U37_03570	COG5444	nuclease activity
B4U37_03590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4U37_03595	COG2356	endonuclease I
B4U37_03610	COG0456	acetyltransferase
B4U37_03615	COG1522	sequence-specific DNA binding
B4U37_03625	COG0640	Transcriptional regulator
B4U37_03635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4U37_03640	COG2205	protein histidine kinase activity
B4U37_03645	COG0745	RESPONSE REGULATOR receiver
B4U37_03650	COG1136	(ABC) transporter
B4U37_03655	COG0577	efflux transmembrane transporter activity
B4U37_03750	COG4326	sporulation control protein
B4U37_03765	COG1268	BioY protein
B4U37_03770	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_03775	COG1595	DNA-templated transcription, initiation
B4U37_03785	COG1595	DNA-templated transcription, initiation
B4U37_03810	COG5002	protein histidine kinase activity
B4U37_03815	COG1607	acyl-coa hydrolase
B4U37_03820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B4U37_03830	COG1132	(ABC) transporter
B4U37_03845	COG0628	permease
B4U37_03850	COG1695	Transcriptional regulator
B4U37_03870	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_03885	COG0681	Belongs to the peptidase S26 family
B4U37_03890	COG3227	Zinc metalloprotease (Elastase)
B4U37_03900	COG1404	Belongs to the peptidase S8 family
B4U37_03905	COG1309	transcriptional regulator
B4U37_03910	COG2814	Major facilitator Superfamily
B4U37_03915	COG2329	Antibiotic biosynthesis monooxygenase
B4U37_03930	COG0322	excinuclease ABC activity
B4U37_03950	COG3290	protein histidine kinase activity
B4U37_03955	COG3279	Response regulator of the LytR AlgR family
B4U37_03965	COG4555	ABC transporter
B4U37_03970	COG1668	transmembrane transport
B4U37_03980	COG3711	transcriptional antiterminator
B4U37_04010	COG2186	Transcriptional regulator
B4U37_04020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4U37_04030	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U37_04040	COG0673	inositol 2-dehydrogenase activity
B4U37_04055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4U37_04060	COG1183	phosphatidylcholine synthase activity
B4U37_04070	COG1960	acyl-CoA dehydrogenase activity
B4U37_04075	COG1966	Carbon starvation protein
B4U37_04080	COG5002	protein histidine kinase activity
B4U37_04085	COG0166	Belongs to the GPI family
B4U37_04090	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_04095	COG2814	Major facilitator Superfamily
B4U37_04100	COG4895	conserved protein (DUF2196)
B4U37_04110	COG2368	4-hydroxyphenylacetate
B4U37_04115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4U37_04125	COG0154	amidase activity
B4U37_04130	COG1132	(ABC) transporter
B4U37_04135	COG1132	(ABC) transporter
B4U37_04140	COG1115	amino acid carrier protein
B4U37_04145	COG2200	EAL domain
B4U37_04155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U37_04155	COG0723	plastoquinol--plastocyanin reductase activity
B4U37_04160	COG0513	Belongs to the DEAD box helicase family
B4U37_04165	COG2124	cytochrome p450
B4U37_04175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U37_04195	COG2244	polysaccharide biosynthetic process
B4U37_04200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U37_04205	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B4U37_04210	COG1077	Cell shape determining protein MreB Mrl
B4U37_04255	COG1486	melibiose metabolic process
B4U37_04265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4U37_04270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4U37_04280	COG0745	RESPONSE REGULATOR receiver
B4U37_04285	COG5002	protein histidine kinase activity
B4U37_04290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U37_04295	COG1988	membrane-bound metal-dependent
B4U37_04300	COG4840	Belongs to the UPF0435 family
B4U37_04310	COG1295	ribonuclease BN
B4U37_04315	COG2217	Heavy metal translocating P-type atpase
B4U37_04340	COG1595	DNA-templated transcription, initiation
B4U37_04350	COG0477	Major facilitator Superfamily
B4U37_04360	COG0024	Methionine aminopeptidase
B4U37_04375	COG1737	Transcriptional regulator
B4U37_04390	COG1175	transmembrane transport
B4U37_04395	COG0395	ABC-type sugar transport system, permease component
B4U37_04400	COG3842	ATPase activity
B4U37_04410	COG3876	Protein conserved in bacteria
B4U37_04415	COG1472	Belongs to the glycosyl hydrolase 3 family
B4U37_04420	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B4U37_04425	COG0247	lactate metabolic process
B4U37_04430	COG0277	FAD linked oxidase domain protein
B4U37_04435	COG3835	regulator
B4U37_04445	COG2364	Membrane
B4U37_04460	COG0535	radical SAM domain protein
B4U37_04485	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4U37_04490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4U37_04495	COG4807	Protein conserved in bacteria
B4U37_04500	COG0673	inositol 2-dehydrogenase activity
B4U37_04510	COG4213	ABC transporter substrate-binding protein
B4U37_04520	COG4214	carbohydrate transport
B4U37_04530	COG2972	Histidine kinase
B4U37_04535	COG2197	response regulator
B4U37_04540	COG4213	ABC transporter substrate-binding protein
B4U37_04545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B4U37_04550	COG0697	spore germination
B4U37_04555	COG3239	Fatty acid desaturase
B4U37_04610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U37_04645	COG3119	arylsulfatase activity
B4U37_04650	COG1280	lysine exporter protein (LysE YggA)
B4U37_04685	COG3773	Cell wall hydrolase
B4U37_04720	COG0697	spore germination
B4U37_04750	COG0398	Pfam SNARE associated Golgi protein
B4U37_04765	COG1657	PFAM Prenyltransferase squalene oxidase
B4U37_04775	COG0745	RESPONSE REGULATOR receiver
B4U37_04780	COG5002	protein histidine kinase activity
B4U37_04825	COG2267	carboxylic ester hydrolase activity
B4U37_04855	COG1388	LysM domain
B4U37_04855	COG0791	NLP P60 protein
B4U37_04870	COG0494	nUDIX hydrolase
B4U37_04885	COG1388	LysM domain
B4U37_04915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_04920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_04925	COG1120	ATPase activity
B4U37_04930	COG2207	Transcriptional regulator
B4U37_04990	COG1595	DNA-templated transcription, initiation
B4U37_05005	COG1131	(ABC) transporter
B4U37_05010	COG3711	transcriptional antiterminator
B4U37_05015	COG1263	PTS System
B4U37_05015	COG2190	(PTS) system
B4U37_05015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U37_05025	COG0716	FMN binding
B4U37_05035	COG0716	FMN binding
B4U37_05040	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B4U37_05050	COG0697	spore germination
B4U37_05060	COG3069	C4-dicarboxylate transmembrane transporter activity
B4U37_05100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B4U37_05105	COG2208	phosphoserine phosphatase activity
B4U37_05110	COG3403	YqcI/YcgG family
B4U37_05115	COG4191	Histidine kinase
B4U37_05130	COG1070	Carbohydrate kinase
B4U37_05165	COG1090	epimerase
B4U37_05175	COG0300	oxidoreductase activity
B4U37_05200	COG1988	membrane-bound metal-dependent
B4U37_05210	COG1194	a g-specific adenine glycosylase
B4U37_05220	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_05235	COG3557	Belongs to the UPF0374 family
B4U37_05240	COG1132	(ABC) transporter
B4U37_05245	COG4129	membrane
B4U37_05250	COG0067	glutamate synthase
B4U37_05250	COG0069	glutamate synthase activity
B4U37_05250	COG0070	glutamate synthase
B4U37_05260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4U37_05265	COG4555	ABC transporter
B4U37_05285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4U37_05290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B4U37_05295	COG2096	Adenosyltransferase
B4U37_05300	COG0735	belongs to the Fur family
B4U37_05420	COG3382	B3 4 domain protein
B4U37_05435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B4U37_05440	COG2766	serine protein kinase
B4U37_05455	COG3279	Response regulator of the LytR AlgR family
B4U37_05460	COG2972	Histidine kinase
B4U37_05465	COG4608	Belongs to the ABC transporter superfamily
B4U37_05470	COG0444	Belongs to the ABC transporter superfamily
B4U37_05475	COG0601	transmembrane transport
B4U37_05490	COG0747	negative chemotaxis
B4U37_05495	COG0402	S-adenosylhomocysteine deaminase activity
B4U37_05500	COG0402	S-adenosylhomocysteine deaminase activity
B4U37_05510	COG2205	protein histidine kinase activity
B4U37_05530	COG0601	transmembrane transport
B4U37_05535	COG0444	Belongs to the ABC transporter superfamily
B4U37_05540	COG4608	Belongs to the ABC transporter superfamily
B4U37_05545	COG0747	negative chemotaxis
B4U37_05550	COG0601	transmembrane transport
B4U37_05555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_05560	COG0444	Belongs to the ABC transporter superfamily
B4U37_05565	COG4608	Belongs to the ABC transporter superfamily
B4U37_05575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4U37_05590	COG1115	amino acid carrier protein
B4U37_05595	COG2514	catechol 2,3-dioxygenase activity
B4U37_05625	COG0346	lactoylglutathione lyase activity
B4U37_05630	COG1253	flavin adenine dinucleotide binding
B4U37_05635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U37_05640	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U37_05640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U37_05650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4U37_05655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4U37_05660	COG2205	protein histidine kinase activity
B4U37_05670	COG0789	Transcriptional regulator
B4U37_05680	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4U37_05690	COG0656	L-ascorbic acid biosynthetic process
B4U37_05705	COG0564	pseudouridine synthase activity
B4U37_05720	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B4U37_05730	COG3153	acetyltransferase
B4U37_05730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4U37_05740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4U37_05750	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U37_05755	COG1501	Belongs to the glycosyl hydrolase 31 family
B4U37_05770	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_05785	COG1175	transmembrane transport
B4U37_05790	COG0395	ABC-type sugar transport system, permease component
B4U37_05795	COG2188	Transcriptional regulator
B4U37_05800	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B4U37_05805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B4U37_05810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B4U37_05815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U37_05820	COG2203	Gaf domain
B4U37_05820	COG4585	Histidine kinase
B4U37_05825	COG2197	response regulator
B4U37_05830	COG0431	NADPH-dependent FMN reductase
B4U37_05840	COG2866	Carboxypeptidase
B4U37_05845	COG2239	Acts as a magnesium transporter
B4U37_05850	COG0730	response to heat
B4U37_05855	COG2719	SpoVR family
B4U37_05865	COG1349	DNA-binding transcription factor activity
B4U37_05870	COG1105	Belongs to the carbohydrate kinase PfkB family
B4U37_05875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U37_05875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U37_05875	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U37_05890	COG1695	Transcriptional regulator
B4U37_05900	COG2112	serine threonine protein kinase
B4U37_05915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B4U37_05925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4U37_05930	COG0569	domain protein
B4U37_05935	COG0398	Pfam SNARE associated Golgi protein
B4U37_05970	COG0582	viral genome integration into host DNA
B4U37_05995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4U37_06025	COG0586	Pfam SNARE associated Golgi protein
B4U37_06035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U37_06040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U37_06045	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_06050	COG4989	oxidoreductase activity
B4U37_06060	COG1301	dicarboxylic acid transport
B4U37_06065	COG2076	Multidrug Resistance protein
B4U37_06090	COG0589	response to stress
B4U37_06095	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B4U37_06105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U37_06115	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_06120	COG2814	Major facilitator Superfamily
B4U37_06125	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B4U37_06130	COG4721	ABC-type cobalt transport system, permease component
B4U37_06135	COG1122	ATPase activity
B4U37_06145	COG0352	thiamine-phosphate diphosphorylase activity
B4U37_06150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U37_06155	COG2104	thiamine diphosphate biosynthetic process
B4U37_06160	COG2022	thiamine diphosphate biosynthetic process
B4U37_06165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4U37_06170	COG0351	phosphomethylpyrimidine kinase
B4U37_06185	COG1278	Cold shock
B4U37_06195	COG1132	(ABC) transporter
B4U37_06200	COG1132	(ABC) transporter
B4U37_06205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U37_06210	COG0765	amino acid transport
B4U37_06215	COG1126	abc transporter atp-binding protein
B4U37_06240	COG3842	ATPase activity
B4U37_06245	COG2508	Transcriptional regulator
B4U37_06265	COG0189	ligase activity
B4U37_06270	COG0189	ligase activity
B4U37_06275	COG0189	ligase activity
B4U37_06280	COG4399	Belongs to the UPF0754 family
B4U37_06290	COG0561	phosphatase activity
B4U37_06295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4U37_06310	COG1024	Enoyl-CoA hydratase
B4U37_06325	COG4152	abc transporter atp-binding protein
B4U37_06330	COG1668	transmembrane transport
B4U37_06340	COG0420	3'-5' exonuclease activity
B4U37_06345	COG4717	serine-type aminopeptidase activity
B4U37_06350	COG2814	Major facilitator Superfamily
B4U37_06355	COG3481	metal-dependent phosphohydrolase, HD sub domain
B4U37_06365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4U37_06400	COG1846	Transcriptional regulator
B4U37_06420	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B4U37_06430	COG0537	adenosine 5'-monophosphoramidase activity
B4U37_06435	COG1131	(ABC) transporter
B4U37_06440	COG4473	ABC transporter
B4U37_06450	COG1473	amidohydrolase
B4U37_06465	COG4585	Histidine kinase
B4U37_06470	COG2197	response regulator
B4U37_06475	COG2329	Antibiotic biosynthesis monooxygenase
B4U37_06480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U37_06485	COG4191	Histidine kinase
B4U37_06490	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B4U37_06505	COG1309	transcriptional regulator
B4U37_06510	COG1511	domain protein
B4U37_06515	COG1609	Transcriptional regulator
B4U37_06520	COG3328	transposase activity
B4U37_06530	COG1234	tRNA 3'-trailer cleavage
B4U37_06535	COG0095	Lipoate-protein ligase
B4U37_06540	COG0318	PFAM AMP-dependent synthetase and ligase
B4U37_06545	COG1024	Enoyl-CoA hydratase
B4U37_06560	COG0501	Belongs to the peptidase M48B family
B4U37_06565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B4U37_06570	COG2224	Isocitrate lyase
B4U37_06580	COG4903	ComK protein
B4U37_06585	COG2323	membrane
B4U37_06590	COG2323	membrane
B4U37_06600	COG0823	Involved in the tonB-independent uptake of proteins
B4U37_06600	COG4946	Tricorn protease homolog
B4U37_06600	COG1506	peptidase
B4U37_06625	COG0398	Pfam SNARE associated Golgi protein
B4U37_06645	COG0411	ABC transporter
B4U37_06655	COG0559	Belongs to the binding-protein-dependent transport system permease family
B4U37_06675	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_06700	COG2814	Major facilitator Superfamily
B4U37_06705	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B4U37_06715	COG0420	3'-5' exonuclease activity
B4U37_06720	COG0419	ATPase involved in DNA repair
B4U37_06725	COG1403	HNH endonuclease
B4U37_06765	COG2311	Membrane
B4U37_06775	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4U37_06780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4U37_06790	COG3300	MHYT domain
B4U37_06790	COG5001	Diguanylate cyclase
B4U37_06800	COG0367	asparagine synthase
B4U37_06815	COG1562	ergosterol biosynthetic process
B4U37_06820	COG1233	COG1233 Phytoene dehydrogenase and related
B4U37_06825	COG1215	transferase activity, transferring glycosyl groups
B4U37_06840	COG0004	ammonium transporteR
B4U37_06845	COG0347	Belongs to the P(II) protein family
B4U37_06850	COG0534	Mate efflux family protein
B4U37_06855	COG2207	Transcriptional regulator
B4U37_06855	COG1917	Cupin 2, conserved barrel domain protein
B4U37_06865	COG2182	Extracellular solute-binding protein
B4U37_06870	COG1175	transmembrane transport
B4U37_06875	COG3833	ABC-type maltose transport systems, permease component
B4U37_06880	COG0366	Alpha amylase catalytic
B4U37_06880	COG1874	Beta-galactosidase
B4U37_06890	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_06895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_06900	COG1666	GTP binding
B4U37_06905	COG2996	Protein conserved in bacteria
B4U37_06915	COG1307	EDD domain protein, DegV family
B4U37_06920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U37_06930	COG0561	phosphatase activity
B4U37_06935	COG1073	alpha beta
B4U37_06940	COG2151	metal-sulfur cluster biosynthetic enzyme
B4U37_06955	COG0542	response to heat
B4U37_06965	COG2267	carboxylic ester hydrolase activity
B4U37_06975	COG1744	ABC transporter substrate-binding protein PnrA-like
B4U37_06990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U37_06995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U37_07005	COG5504	Zn-dependent protease
B4U37_07010	COG0444	Belongs to the ABC transporter superfamily
B4U37_07015	COG4608	Belongs to the ABC transporter superfamily
B4U37_07025	COG0601	transmembrane transport
B4U37_07030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_07045	COG0180	Tryptophanyl-tRNA synthetase
B4U37_07055	COG4166	transmembrane transport
B4U37_07060	COG0601	transmembrane transport
B4U37_07065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_07070	COG0444	Belongs to the ABC transporter superfamily
B4U37_07075	COG4608	Belongs to the ABC transporter superfamily
B4U37_07090	COG0456	acetyltransferase
B4U37_07100	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_07105	COG4605	iron ion homeostasis
B4U37_07110	COG4604	ABC transporter, ATP-binding protein
B4U37_07115	COG4607	ABC-type enterochelin transport system periplasmic component
B4U37_07130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4U37_07135	COG1393	Belongs to the ArsC family
B4U37_07140	COG0861	Integral membrane protein TerC family
B4U37_07145	COG4862	establishment of competence for transformation
B4U37_07150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4U37_07160	COG1164	Oligoendopeptidase f
B4U37_07170	COG2346	COG2346, Truncated hemoglobins
B4U37_07180	COG0741	lytic transglycosylase activity
B4U37_07185	COG4116	CYTH
B4U37_07195	COG2357	RelA SpoT domain protein
B4U37_07200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4U37_07205	COG0564	pseudouridine synthase activity
B4U37_07210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B4U37_07215	COG0475	glutathione-regulated potassium exporter activity
B4U37_07215	COG0589	response to stress
B4U37_07220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B4U37_07260	COG0438	transferase activity, transferring glycosyl groups
B4U37_07320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U37_07330	COG2323	membrane
B4U37_07360	COG0210	DNA helicase
B4U37_07370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_07375	COG2323	membrane
B4U37_07380	COG2153	protein acetylation
B4U37_07385	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B4U37_07390	COG2382	esterase
B4U37_07410	COG1999	signal sequence binding
B4U37_07415	COG1418	mRNA catabolic process
B4U37_07480	COG1363	Peptidase, m42
B4U37_07495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4U37_07515	COG2894	cell division
B4U37_07535	COG1533	DNA photolyase activity
B4U37_07545	COG2720	vancomycin resistance protein
B4U37_07565	COG4106	trans-aconitate 2-methyltransferase activity
B4U37_07570	COG3584	3D domain protein
B4U37_07570	COG1388	LysM domain
B4U37_07580	COG0671	phosphoesterase, PA-phosphatase related
B4U37_07600	COG3844	kynureninase activity
B4U37_07640	COG0668	transmembrane transport
B4U37_07665	COG1793	dna ligase
B4U37_07665	COG3285	dna ligase
B4U37_07670	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B4U37_07675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U37_07675	COG3320	Male sterility
B4U37_07685	COG1191	sigma factor activity
B4U37_07700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4U37_07725	COG0395	ABC-type sugar transport system, permease component
B4U37_07740	COG5002	protein histidine kinase activity
B4U37_07745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4U37_07760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B4U37_07765	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B4U37_07770	COG1278	Cold shock
B4U37_07775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4U37_07780	COG0436	Aminotransferase
B4U37_07785	COG1850	ribulose-bisphosphate carboxylase activity
B4U37_07790	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
B4U37_07795	COG0235	Class ii aldolase
B4U37_07800	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B4U37_07810	COG0446	pyridine nucleotide-disulphide oxidoreductase
B4U37_07820	COG2861	carbohydrate metabolic process
B4U37_07840	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B4U37_07850	COG3639	organic phosphonate transmembrane transporter activity
B4U37_07855	COG0737	Belongs to the 5'-nucleotidase family
B4U37_07860	COG1846	Transcriptional regulator
B4U37_07870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4U37_07890	COG0542	response to heat
B4U37_07900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4U37_07910	COG3949	Membrane
B4U37_07915	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4U37_07945	COG0720	synthase
B4U37_07955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B4U37_07970	COG0702	epimerase
B4U37_07980	COG4873	Protein conserved in bacteria
B4U37_08035	COG1725	Transcriptional regulator
B4U37_08040	COG1131	(ABC) transporter
B4U37_08050	COG1131	(ABC) transporter
B4U37_08055	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4U37_08080	COG0018	arginyl-trna synthetase
B4U37_08095	COG2267	carboxylic ester hydrolase activity
B4U37_08110	COG3546	catalase activity
B4U37_08115	COG1388	LysM domain
B4U37_08115	COG0791	NLP P60 protein
B4U37_08135	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_08150	COG2986	histidine ammonia-lyase
B4U37_08165	COG0010	Belongs to the arginase family
B4U37_08170	COG2084	Dehydrogenase
B4U37_08175	COG4191	Histidine kinase
B4U37_08180	COG0733	neurotransmitter:sodium symporter activity
B4U37_08185	COG1404	Belongs to the peptidase S8 family
B4U37_08195	COG1595	DNA-templated transcription, initiation
B4U37_08210	COG0436	Aminotransferase
B4U37_08230	COG2252	PERMEase
B4U37_08240	COG2205	protein histidine kinase activity
B4U37_08255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_08260	COG0071	Belongs to the small heat shock protein (HSP20) family
B4U37_08290	COG1473	amidohydrolase
B4U37_08305	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B4U37_08310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U37_08320	COG3594	Acyltransferase
B4U37_08365	COG3180	Ammonia monooxygenase
B4U37_08370	COG2814	Major facilitator Superfamily
B4U37_08385	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4U37_08395	COG5522	Integral membrane protein (intg_mem_TP0381)
B4U37_08420	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_08425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U37_08430	COG1595	DNA-templated transcription, initiation
B4U37_08460	COG4842	Belongs to the WXG100 family
B4U37_08465	COG5417	Belongs to the EsaB family
B4U37_08470	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4U37_08475	COG1674	ftsk spoiiie
B4U37_08475	COG0433	COG0433 Predicted ATPase
B4U37_08480	COG1511	domain protein
B4U37_08490	COG3290	protein histidine kinase activity
B4U37_08490	COG3829	transcription factor binding
B4U37_08495	COG0318	PFAM AMP-dependent synthetase and ligase
B4U37_08505	COG0183	Belongs to the thiolase family
B4U37_08515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B4U37_08520	COG0318	PFAM AMP-dependent synthetase and ligase
B4U37_08545	COG1595	DNA-templated transcription, initiation
B4U37_08550	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_08555	COG0745	RESPONSE REGULATOR receiver
B4U37_08560	COG5002	protein histidine kinase activity
B4U37_08565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4U37_08590	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U37_08600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4U37_08610	COG4667	esterase of the alpha-beta hydrolase superfamily
B4U37_08615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U37_08625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B4U37_08630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4U37_08635	COG0129	dihydroxy-acid dehydratase activity
B4U37_08640	COG0028	Belongs to the TPP enzyme family
B4U37_08645	COG0440	acetolactate synthase activity
B4U37_08650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B4U37_08655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U37_08665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B4U37_08670	COG0066	3-isopropylmalate dehydratase activity
B4U37_08685	COG4589	Belongs to the CDS family
B4U37_08695	COG0110	maltose O-acetyltransferase activity
B4U37_08705	COG1216	Glycosyl transferase, family 2
B4U37_08710	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_08720	COG0702	epimerase
B4U37_08730	COG3610	response to peptide
B4U37_08735	COG2966	Psort location CytoplasmicMembrane, score
B4U37_08740	COG2340	Cysteine-rich secretory protein family
B4U37_08750	COG0363	glucosamine-6-phosphate deaminase activity
B4U37_08755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4U37_08760	COG1247	-acetyltransferase
B4U37_08770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_08785	COG1686	Belongs to the peptidase S11 family
B4U37_08800	COG1960	acyl-CoA dehydrogenase activity
B4U37_08810	COG4145	pantothenate transmembrane transporter activity
B4U37_08820	COG2333	competence protein COMEC
B4U37_08820	COG0658	competence protein
B4U37_08835	COG2190	(PTS) system
B4U37_08840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U37_08840	COG1263	PTS System
B4U37_08845	COG0366	Alpha amylase catalytic
B4U37_08850	COG0366	Alpha amylase catalytic
B4U37_08855	COG2188	Transcriptional regulator
B4U37_08865	COG0784	Response regulator, receiver
B4U37_08865	COG0835	chemotaxis
B4U37_08875	COG3437	response regulator, receiver
B4U37_08875	COG2770	Histidine kinase
B4U37_08880	COG1376	ErfK ybiS ycfS ynhG family protein
B4U37_08890	COG1408	metallophosphoesterase
B4U37_08895	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_08910	COG2200	EAL domain
B4U37_08935	COG4703	Protein of unknown function (DUF1797)
B4U37_08940	COG5506	Protein of unknown function (DUF1694)
B4U37_08950	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B4U37_08955	COG0517	IMP dehydrogenase activity
B4U37_08960	COG0477	Major facilitator Superfamily
B4U37_08970	COG0583	DNA-binding transcription factor activity
B4U37_08985	COG1473	amidohydrolase
B4U37_09000	COG0668	transmembrane transport
B4U37_09005	COG0450	alkyl hydroperoxide reductase
B4U37_09010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_09015	COG1132	(ABC) transporter
B4U37_09020	COG1132	(ABC) transporter
B4U37_09030	COG0569	domain protein
B4U37_09035	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4U37_09045	COG0697	spore germination
B4U37_09050	COG0561	phosphatase activity
B4U37_09070	COG0022	dehydrogenase e1 component
B4U37_09075	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U37_09080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U37_09115	COG1982	Orn Lys Arg decarboxylase major
B4U37_09125	COG4476	Belongs to the UPF0223 family
B4U37_09130	COG4493	Belongs to the UPF0637 family
B4U37_09140	COG0483	inositol monophosphate 1-phosphatase activity
B4U37_09170	COG4896	Protein conserved in bacteria
B4U37_09190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B4U37_09195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4U37_09200	COG2066	Belongs to the glutaminase family
B4U37_09205	COG4838	Belongs to the UPF0358 family
B4U37_09210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B4U37_09225	COG1612	heme a metabolic process
B4U37_09255	COG3328	transposase activity
B4U37_09260	COG3336	cytochrome c oxidase
B4U37_09285	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B4U37_09290	COG2340	Cysteine-rich secretory protein family
B4U37_09320	COG3679	Belongs to the UPF0342 family
B4U37_09330	COG4471	UPF0298 protein
B4U37_09345	COG0742	ribosomal rna small subunit methyltransferase
B4U37_09350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B4U37_09355	COG3314	Sporulation integral membrane protein YlbJ
B4U37_09360	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4U37_09365	COG3480	Lon protease (S16) C-terminal proteolytic domain
B4U37_09370	COG1323	Belongs to the UPF0348 family
B4U37_09375	COG1399	metal-binding, possibly nucleic acid-binding protein
B4U37_09385	COG1024	Enoyl-CoA hydratase
B4U37_09395	COG3011	Protein conserved in bacteria
B4U37_09405	COG0454	-acetyltransferase
B4U37_09410	COG0439	Biotin carboxylase
B4U37_09415	COG0511	ligase activity, forming carbon-carbon bonds
B4U37_09420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U37_09425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4U37_09435	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B4U37_09440	COG2001	Belongs to the MraZ family
B4U37_09445	COG0275	rRNA processing
B4U37_09465	COG0768	penicillin binding
B4U37_09475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4U37_09480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4U37_09485	COG0772	Belongs to the SEDS family
B4U37_09490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B4U37_09495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4U37_09500	COG3879	Bacterial protein of unknown function (DUF881)
B4U37_09505	COG3879	Bacterial protein of unknown function (DUF881)
B4U37_09510	COG3856	small basic protein
B4U37_09515	COG0849	cell division
B4U37_09520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B4U37_09530	COG1191	sigma factor activity
B4U37_09535	COG1191	sigma factor activity
B4U37_09540	COG1873	PFAM PRC-barrel domain
B4U37_09550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4U37_09555	COG1799	cell septum assembly
B4U37_09560	COG0762	integral membrane protein
B4U37_09565	COG2302	S4 RNA-binding domain
B4U37_09570	COG3599	regulation of cell shape
B4U37_09580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B4U37_09585	COG0564	pseudouridine synthase activity
B4U37_09590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B4U37_09595	COG2233	PERMEase
B4U37_09600	COG0540	Belongs to the ATCase OTCase family
B4U37_09605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4U37_09620	COG0543	2 iron, 2 sulfur cluster binding
B4U37_09630	COG0284	orotidine-5'-phosphate decarboxylase activity
B4U37_09635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B4U37_09655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4U37_09660	COG1561	YicC-like family, N-terminal region
B4U37_09665	COG2052	Domain of unknown function (DUF370)
B4U37_09670	COG0194	GDP metabolic process
B4U37_09675	COG1758	RNA polymerase activity
B4U37_09680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4U37_09685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4U37_09695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B4U37_09700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4U37_09700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4U37_09705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B4U37_09710	COG0631	protein serine/threonine phosphatase activity
B4U37_09715	COG0515	serine threonine protein kinase
B4U37_09715	COG2815	serine threonine protein kinase
B4U37_09720	COG1162	GTPase activity
B4U37_09725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4U37_09735	COG1564	THIamine pyrophosphokinase
B4U37_09745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B4U37_09755	COG1302	Protein conserved in bacteria
B4U37_09760	COG1461	Dihydroxyacetone kinase
B4U37_09765	COG1760	l-serine dehydratase
B4U37_09770	COG1760	l-serine dehydratase
B4U37_09775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4U37_09780	COG2050	protein possibly involved in aromatic compounds catabolism
B4U37_09780	COG1349	DNA-binding transcription factor activity
B4U37_09785	COG0416	fatty acid biosynthetic process
B4U37_09790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B4U37_09795	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_09800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U37_09805	COG0571	ribonuclease III activity
B4U37_09810	COG1196	nuclear chromosome segregation
B4U37_09815	COG0552	protein localization to endoplasmic reticulum
B4U37_09830	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B4U37_09835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4U37_09845	COG1837	Belongs to the UPF0109 family
B4U37_09850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B4U37_09885	COG2257	FlhB HrpN YscU SpaS Family
B4U37_09895	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B4U37_09900	COG0758	DNA mediated transformation
B4U37_09905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4U37_09910	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B4U37_09915	COG4974	Belongs to the 'phage' integrase family
B4U37_09920	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B4U37_09925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B4U37_09930	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B4U37_09935	COG1815	bacterial-type flagellum-dependent cell motility
B4U37_09940	COG1558	bacterial-type flagellum-dependent cell motility
B4U37_09945	COG1677	Flagellar hook-basal body complex protein FliE
B4U37_09950	COG1766	The M ring may be actively involved in energy transduction
B4U37_09955	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4U37_09960	COG1317	bacterial-type flagellum organization
B4U37_09965	COG1157	protein secretion by the type III secretion system
B4U37_09980	COG3144	bacterial-type flagellum assembly
B4U37_09985	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B4U37_10005	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4U37_10010	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4U37_10010	COG1776	CheC inhibitor of MCP methylation
B4U37_10015	COG2201	protein-glutamate methylesterase activity
B4U37_10020	COG3190	flagellar
B4U37_10025	COG1338	Plays a role in the flagellum-specific transport system
B4U37_10030	COG1987	bacterial-type flagellum assembly
B4U37_10035	COG1684	flagellar biosynthetic protein fliR
B4U37_10040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4U37_10045	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4U37_10050	COG1419	protein localization to endoplasmic reticulum
B4U37_10055	COG0455	bacterial-type flagellum organization
B4U37_10060	COG2201	protein-glutamate methylesterase activity
B4U37_10065	COG2198	Histidine kinase
B4U37_10065	COG0643	Histidine kinase
B4U37_10070	COG0835	chemotaxis
B4U37_10075	COG1776	CheC inhibitor of MCP methylation
B4U37_10080	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B4U37_10085	COG1191	sigma factor activity
B4U37_10095	COG0052	Belongs to the universal ribosomal protein uS2 family
B4U37_10120	COG4589	Belongs to the CDS family
B4U37_10125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B4U37_10130	COG0750	zinc metalloprotease
B4U37_10140	COG2176	DNA-directed DNA polymerase activity
B4U37_10150	COG0195	Participates in both transcription termination and antitermination
B4U37_10155	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B4U37_10160	COG1358	cellular component organization or biogenesis
B4U37_10170	COG1550	Protein conserved in bacteria
B4U37_10175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B4U37_10180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B4U37_10185	COG0196	riboflavin kinase activity
B4U37_10190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B4U37_10195	COG1185	polyribonucleotide nucleotidyltransferase activity
B4U37_10200	COG0726	polysaccharide deacetylase
B4U37_10205	COG0612	Peptidase, M16
B4U37_10210	COG1873	PFAM PRC-barrel domain
B4U37_10215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U37_10220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4U37_10225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4U37_10230	COG0527	aspartate kinase activity
B4U37_10235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4U37_10245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4U37_10250	COG0740	serine-type endopeptidase activity
B4U37_10260	COG4980	gas vesicle protein
B4U37_10260	COG1674	ftsk spoiiie
B4U37_10265	COG2188	Transcriptional regulator
B4U37_10270	COG0612	Peptidase, M16
B4U37_10275	COG0612	Peptidase, M16
B4U37_10280	COG0300	oxidoreductase activity
B4U37_10295	COG1426	Protein conserved in bacteria
B4U37_10300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4U37_10305	COG1546	Belongs to the CinA family
B4U37_10305	COG1058	Belongs to the CinA family
B4U37_10315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B4U37_10320	COG1418	mRNA catabolic process
B4U37_10325	COG1692	metallophosphoesterase
B4U37_10330	COG2359	stage V sporulation protein S
B4U37_10345	COG1013	pyruvate-flavodoxin oxidoreductase activity
B4U37_10350	COG1063	alcohol dehydrogenase
B4U37_10355	COG0156	8-amino-7-oxononanoate synthase activity
B4U37_10360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4U37_10365	COG4550	Control of competence regulator ComK, YlbF/YmcA
B4U37_10380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B4U37_10385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B4U37_10400	COG0464	growth
B4U37_10405	COG1233	COG1233 Phytoene dehydrogenase and related
B4U37_10415	COG2860	membrane
B4U37_10425	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B4U37_10430	COG3328	transposase activity
B4U37_10435	COG0789	Transcriptional regulator
B4U37_10440	COG0174	glutamine synthetase
B4U37_10460	COG2323	membrane
B4U37_10465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B4U37_10470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4U37_10475	COG4224	UPF0291 protein
B4U37_10490	COG3763	UPF0154 protein
B4U37_10495	COG1132	(ABC) transporter
B4U37_10500	COG1132	(ABC) transporter
B4U37_10510	COG0785	Cytochrome C biogenesis protein
B4U37_10515	COG2201	protein-glutamate methylesterase activity
B4U37_10520	COG4846	Membrane protein involved in cytochrome C biogenesis
B4U37_10530	COG1484	DNA-dependent DNA replication
B4U37_10535	COG0714	Associated with various cellular activities
B4U37_10550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U37_10555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B4U37_10560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B4U37_10605	COG1131	(ABC) transporter
B4U37_10655	COG1921	L-seryl-tRNASec selenium transferase activity
B4U37_10675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B4U37_10685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_10715	COG0824	Thioesterase
B4U37_10725	COG4841	protein insertion into membrane
B4U37_10730	COG2843	Capsule synthesis protein
B4U37_10770	COG4326	sporulation control protein
B4U37_10775	COG0588	phosphoglycerate mutase activity
B4U37_10785	COG0346	lactoylglutathione lyase activity
B4U37_10790	COG1056	cytidyltransferase-related domain
B4U37_10790	COG1051	belongs to the nudix hydrolase family
B4U37_10795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B4U37_10800	COG1832	CoA-binding protein
B4U37_10805	COG0187	DNA topoisomerase II activity
B4U37_10810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4U37_10820	COG1335	isochorismatase
B4U37_10825	COG0590	tRNA wobble adenosine to inosine editing
B4U37_10840	COG1733	regulation of RNA biosynthetic process
B4U37_10860	COG1131	(ABC) transporter
B4U37_10865	COG1309	transcriptional regulator
B4U37_10895	COG3459	Glycosyltransferase 36 associated
B4U37_10900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B4U37_10905	COG1823	symporter activity
B4U37_10910	COG3906	Belongs to the UPF0473 family
B4U37_10930	COG2197	response regulator
B4U37_10935	COG4585	Histidine kinase
B4U37_10940	COG1994	Peptidase M50
B4U37_10950	COG1271	oxidase subunit
B4U37_10955	COG1294	oxidase, subunit
B4U37_10975	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B4U37_10980	COG4565	transcriptional regulatory protein
B4U37_10985	COG3290	protein histidine kinase activity
B4U37_10990	COG2391	methyltransferase activity
B4U37_11005	COG0662	Cupin 2, conserved barrel domain protein
B4U37_11010	COG0346	lactoylglutathione lyase activity
B4U37_11020	COG1714	RDD family
B4U37_11035	COG0714	Associated with various cellular activities
B4U37_11055	COG0322	excinuclease ABC activity
B4U37_11060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U37_11065	COG1785	Belongs to the alkaline phosphatase family
B4U37_11070	COG1082	Xylose isomerase domain protein TIM barrel
B4U37_11080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U37_11085	COG0318	PFAM AMP-dependent synthetase and ligase
B4U37_11090	COG4264	IucA IucC family
B4U37_11100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U37_11100	COG2207	Transcriptional regulator
B4U37_11110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B4U37_11120	COG0003	Pfam Anion-transporting ATPase
B4U37_11130	COG1966	Carbon starvation protein
B4U37_11145	COG0514	ATP-dependent DNA helicase (RecQ)
B4U37_11150	COG2353	YceI-like domain
B4U37_11165	COG3328	transposase activity
B4U37_11170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U37_11190	COG2309	aminopeptidase activity
B4U37_11210	COG0708	Exodeoxyribonuclease III
B4U37_11230	COG0644	oxidoreductase
B4U37_11235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B4U37_11245	COG0583	DNA-binding transcription factor activity
B4U37_11250	COG0372	Belongs to the citrate synthase family
B4U37_11255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4U37_11270	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B4U37_11275	COG1295	ribonuclease BN
B4U37_11280	COG1834	amidinotransferase
B4U37_11290	COG2340	Cysteine-rich secretory protein family
B4U37_11295	COG0673	inositol 2-dehydrogenase activity
B4U37_11300	COG0693	protein deglycase activity
B4U37_11305	COG0165	Argininosuccinate lyase
B4U37_11310	COG0137	argininosuccinate synthase activity
B4U37_11315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B4U37_11320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4U37_11325	COG0505	Belongs to the CarA family
B4U37_11330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4U37_11340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B4U37_11355	COG0673	inositol 2-dehydrogenase activity
B4U37_11375	COG0318	PFAM AMP-dependent synthetase and ligase
B4U37_11385	COG2223	nitrite transmembrane transporter activity
B4U37_11400	COG0346	lactoylglutathione lyase activity
B4U37_11405	COG2404	hydrolase activity, acting on ester bonds
B4U37_11410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U37_11425	COG0514	ATP-dependent DNA helicase (RecQ)
B4U37_11430	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_11450	COG0488	(ABC) transporter
B4U37_11455	COG0628	permease
B4U37_11465	COG1272	protein, Hemolysin III
B4U37_11475	COG2133	pyrroloquinoline quinone binding
B4U37_11495	COG3773	Cell wall hydrolase
B4U37_11520	COG0406	alpha-ribazole phosphatase activity
B4U37_11525	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B4U37_11535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4U37_11540	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B4U37_11545	COG1120	ATPase activity
B4U37_11550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_11555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U37_11560	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B4U37_11565	COG1492	cobalamin metabolic process
B4U37_11575	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B4U37_11590	COG1335	isochorismatase
B4U37_11595	COG1683	Conserved Protein
B4U37_11610	COG0492	ferredoxin-NADP+ reductase activity
B4U37_11615	COG1959	2 iron, 2 sulfur cluster binding
B4U37_11620	COG3853	Toxic anion resistance protein (TelA)
B4U37_11630	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_11645	COG0671	phosphoesterase, PA-phosphatase related
B4U37_11650	COG4548	von Willebrand factor, type A
B4U37_11655	COG0714	Associated with various cellular activities
B4U37_11660	COG0861	Integral membrane protein TerC family
B4U37_11665	COG0534	Mate efflux family protein
B4U37_11675	COG2340	Cysteine-rich secretory protein family
B4U37_11685	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4U37_11690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4U37_11695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4U37_11700	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B4U37_11705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U37_11710	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U37_11735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4U37_11740	COG4120	Belongs to the binding-protein-dependent transport system permease family
B4U37_11760	COG3327	negative regulation of DNA-templated transcription, initiation
B4U37_11765	COG0183	Belongs to the thiolase family
B4U37_11770	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U37_11775	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_11780	COG1024	Enoyl-CoA hydratase
B4U37_11810	COG3396	Phenylacetate-CoA oxygenase
B4U37_11815	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B4U37_11830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4U37_11835	COG0400	carboxylic ester hydrolase activity
B4U37_11855	COG1876	peptidase activity
B4U37_11860	COG0432	Pfam Uncharacterised protein family UPF0047
B4U37_11890	COG4479	Belongs to the UPF0346 family
B4U37_11900	COG1509	lysine 2,3-aminomutase activity
B4U37_11905	COG3829	transcription factor binding
B4U37_11910	COG0456	acetyltransferase
B4U37_11925	COG0697	spore germination
B4U37_11930	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B4U37_11940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U37_11945	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B4U37_11950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4U37_11955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4U37_11965	COG0840	transmembrane signaling receptor activity
B4U37_11975	COG1309	transcriptional regulator
B4U37_11980	COG2755	lipolytic protein G-D-S-L family
B4U37_11985	COG1131	(ABC) transporter
B4U37_11990	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4U37_11995	COG1562	ergosterol biosynthetic process
B4U37_12050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U37_12050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U37_12070	COG0789	Transcriptional regulator
B4U37_12075	COG3275	phosphorelay sensor kinase activity
B4U37_12085	COG1966	Carbon starvation protein
B4U37_12115	COG2755	lipolytic protein G-D-S-L family
B4U37_12120	COG1999	signal sequence binding
B4U37_12125	COG2814	Major facilitator Superfamily
B4U37_12145	COG0714	Associated with various cellular activities
B4U37_12160	COG1131	(ABC) transporter
B4U37_12200	COG3328	transposase activity
B4U37_12215	COG2135	peptidase activity
B4U37_12240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4U37_12250	COG2521	methyltransferase
B4U37_12250	COG2136	Putative SAM-dependent methyltransferase
B4U37_12260	COG1413	lyase activity
B4U37_12265	COG0488	(ABC) transporter
B4U37_12270	COG1418	mRNA catabolic process
B4U37_12285	COG1307	EDD domain protein, DegV family
B4U37_12295	COG0386	Belongs to the glutathione peroxidase family
B4U37_12305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4U37_12330	COG2808	Putative FMN-binding domain
B4U37_12335	COG4555	ABC transporter
B4U37_12360	COG0390	transport system, permease component
B4U37_12365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4U37_12370	COG0551	DNA topoisomerase type I activity
B4U37_12370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4U37_12380	COG1278	Cold shock
B4U37_12395	COG0328	RNA-DNA hybrid ribonuclease activity
B4U37_12400	COG0328	RNA-DNA hybrid ribonuclease activity
B4U37_12410	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B4U37_12420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U37_12440	COG3541	Predicted nucleotidyltransferase
B4U37_12445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4U37_12450	COG1755	Isoprenylcysteine carboxyl methyltransferase
B4U37_12455	COG3424	synthase
B4U37_12470	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B4U37_12480	COG1199	ATP-dependent helicase activity
B4U37_12485	COG3328	transposase activity
B4U37_12500	COG0116	Belongs to the methyltransferase superfamily
B4U37_12525	COG3359	exonuclease
B4U37_12530	COG1111	helicase
B4U37_12530	COG1205	dead DEAH box helicase
B4U37_12590	COG3331	DNA recombination
B4U37_12595	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4U37_12595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U37_12605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4U37_12610	COG3935	DnaD domain protein
B4U37_12615	COG0017	Asparaginyl-tRNA synthetase
B4U37_12635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4U37_12635	COG1199	ATP-dependent helicase activity
B4U37_12640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B4U37_12660	COG0617	tRNA 3'-terminal CCA addition
B4U37_12665	COG0438	transferase activity, transferring glycosyl groups
B4U37_12670	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4U37_12675	COG1803	Methylglyoxal synthase
B4U37_12685	COG1694	Mazg nucleotide pyrophosphohydrolase
B4U37_12690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U37_12695	COG2738	Putative neutral zinc metallopeptidase
B4U37_12705	COG4347	Protein of unknown function (DUF1405)
B4U37_12715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4U37_12735	COG5582	Belongs to the UPF0302 family
B4U37_12740	COG0457	Tetratricopeptide repeat
B4U37_12750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B4U37_12755	COG0287	Prephenate dehydrogenase
B4U37_12760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4U37_12765	COG0159	tryptophan synthase activity
B4U37_12770	COG0133	tryptophan synthase activity
B4U37_12775	COG0135	phosphoribosylanthranilate isomerase activity
B4U37_12780	COG0134	indole-3-glycerol-phosphate synthase activity
B4U37_12785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4U37_12795	COG4401	Chorismate mutase type I
B4U37_12800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B4U37_12805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B4U37_12810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B4U37_12815	COG0105	UTP biosynthetic process
B4U37_12820	COG0142	geranyltranstransferase activity
B4U37_12825	COG2226	methyltransferase
B4U37_12830	COG0142	geranyltranstransferase activity
B4U37_12840	COG0302	gtp cyclohydrolase
B4U37_12845	COG0776	regulation of translation
B4U37_12850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4U37_12900	COG1304	FMN binding
B4U37_12905	COG0539	negative regulation of cytoplasmic translation
B4U37_12915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B4U37_12930	COG2959	enzyme of heme biosynthesis
B4U37_12935	COG3773	Cell wall hydrolase
B4U37_12935	COG3409	Peptidoglycan-binding domain 1 protein
B4U37_12940	COG2339	peptidase activity
B4U37_12950	COG0492	ferredoxin-NADP+ reductase activity
B4U37_12955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4U37_12960	COG4862	establishment of competence for transformation
B4U37_12965	COG0789	Transcriptional regulator
B4U37_12970	COG1408	metallophosphoesterase
B4U37_12985	COG1266	CAAX protease self-immunity
B4U37_12990	COG0514	ATP-dependent DNA helicase (RecQ)
B4U37_12995	COG4955	Helix-turn-helix domain
B4U37_13000	COG1141	Ferredoxin
B4U37_13005	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B4U37_13010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4U37_13020	COG0697	spore germination
B4U37_13025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4U37_13030	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_13035	COG2610	gluconate transmembrane transporter activity
B4U37_13045	COG1595	DNA-templated transcription, initiation
B4U37_13065	COG5002	protein histidine kinase activity
B4U37_13070	COG0745	RESPONSE REGULATOR receiver
B4U37_13075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4U37_13080	COG1333	cytochrome c biogenesis protein
B4U37_13085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_13090	COG1187	pseudouridine synthase activity
B4U37_13095	COG0700	Nucleoside recognition
B4U37_13100	COG2715	membrane protein required for spore maturation
B4U37_13105	COG1686	Belongs to the peptidase S11 family
B4U37_13110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4U37_13125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B4U37_13130	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B4U37_13135	COG1547	Domain of unknown function (DUF309)
B4U37_13145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B4U37_13150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4U37_13150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4U37_13155	COG0307	riboflavin synthase, alpha
B4U37_13160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4U37_13160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4U37_13165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4U37_13190	COG0697	spore germination
B4U37_13205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U37_13230	COG2172	sigma factor antagonist activity
B4U37_13240	COG1686	Belongs to the peptidase S11 family
B4U37_13260	COG4974	Belongs to the 'phage' integrase family
B4U37_13270	COG0735	belongs to the Fur family
B4U37_13275	COG1300	Membrane
B4U37_13280	COG1379	DNA repair
B4U37_13285	COG0494	nUDIX hydrolase
B4U37_13295	COG0667	Aldo Keto reductase
B4U37_13310	COG0753	catalase activity
B4U37_13345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4U37_13360	COG0477	Major facilitator Superfamily
B4U37_13370	COG2217	Heavy metal translocating P-type atpase
B4U37_13400	COG3340	Belongs to the peptidase S51 family
B4U37_13420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B4U37_13425	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4U37_13430	COG0183	Belongs to the thiolase family
B4U37_13435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U37_13440	COG1742	UPF0060 membrane protein
B4U37_13495	COG1073	alpha beta
B4U37_13515	COG0778	Nitroreductase
B4U37_13520	COG3403	YqcI/YcgG family
B4U37_13525	COG1280	lysine exporter protein (LysE YggA)
B4U37_13545	COG0454	-acetyltransferase
B4U37_13550	COG2824	Alkylphosphonate utilization operon protein PhnA
B4U37_13560	COG1476	TRANSCRIPTIONal
B4U37_13595	COG2755	lipolytic protein G-D-S-L family
B4U37_13610	COG0577	efflux transmembrane transporter activity
B4U37_13615	COG1136	(ABC) transporter
B4U37_13620	COG5002	protein histidine kinase activity
B4U37_13625	COG0745	RESPONSE REGULATOR receiver
B4U37_13635	COG1193	negative regulation of DNA recombination
B4U37_13640	COG2323	membrane
B4U37_13655	COG0456	acetyltransferase
B4U37_13665	COG0681	Belongs to the peptidase S26 family
B4U37_13690	COG4555	ABC transporter
B4U37_13710	COG0534	Mate efflux family protein
B4U37_13725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_13730	COG0601	transmembrane transport
B4U37_13745	COG0546	phosphoglycolate phosphatase activity
B4U37_13765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4U37_13790	COG0300	oxidoreductase activity
B4U37_13795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_13800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U37_13815	COG4187	Peptidase family M20/M25/M40
B4U37_13820	COG1902	pentaerythritol trinitrate reductase activity
B4U37_13830	COG0500	methyltransferase
B4U37_13830	COG3615	Tellurite resistance protein tehB
B4U37_13860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4U37_13865	COG1846	Transcriptional regulator
B4U37_13870	COG1764	response to oxidative stress
B4U37_13875	COG0835	chemotaxis
B4U37_13880	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4U37_13890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U37_13895	COG0346	lactoylglutathione lyase activity
B4U37_13910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B4U37_13920	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B4U37_13925	COG1942	4-Oxalocrotonate Tautomerase
B4U37_13935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U37_13955	COG0251	oxidation-reduction process
B4U37_13975	COG2368	4-hydroxyphenylacetate
B4U37_13980	COG1376	ErfK ybiS ycfS ynhG family protein
B4U37_13985	COG4129	membrane
B4U37_13990	COG1164	Oligoendopeptidase f
B4U37_14000	COG1126	abc transporter atp-binding protein
B4U37_14005	COG0765	amino acid transport
B4U37_14010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U37_14020	COG1595	DNA-templated transcription, initiation
B4U37_14025	COG5002	protein histidine kinase activity
B4U37_14045	COG1703	isobutyryl-CoA mutase activity
B4U37_14050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U37_14050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U37_14055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U37_14070	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U37_14075	COG0022	dehydrogenase e1 component
B4U37_14080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4U37_14085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U37_14090	COG3426	butyrate kinase activity
B4U37_14100	COG0280	phosphate acetyltransferase
B4U37_14105	COG3290	protein histidine kinase activity
B4U37_14105	COG3829	transcription factor binding
B4U37_14115	COG0584	glycerophosphoryl diester phosphodiesterase
B4U37_14120	COG3093	addiction module antidote protein HigA
B4U37_14125	COG0745	RESPONSE REGULATOR receiver
B4U37_14130	COG0750	zinc metalloprotease
B4U37_14135	COG0497	DNA recombination
B4U37_14145	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B4U37_14150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B4U37_14155	COG0142	geranyltranstransferase activity
B4U37_14160	COG1722	exodeoxyribonuclease VII activity
B4U37_14165	COG1570	exodeoxyribonuclease VII activity
B4U37_14170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B4U37_14180	COG1302	Protein conserved in bacteria
B4U37_14185	COG0439	Biotin carboxylase
B4U37_14190	COG0511	ligase activity, forming carbon-carbon bonds
B4U37_14235	COG3854	ATPases associated with a variety of cellular activities
B4U37_14245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4U37_14250	COG0778	Nitroreductase
B4U37_14275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B4U37_14300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4U37_14305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4U37_14335	COG1051	belongs to the nudix hydrolase family
B4U37_14385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U37_14405	COG1247	-acetyltransferase
B4U37_14485	COG5609	conserved protein (DUF2294)
B4U37_14495	COG2267	carboxylic ester hydrolase activity
B4U37_14505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4U37_14510	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4U37_14515	COG1129	ABC transporter
B4U37_14530	COG0366	Alpha amylase catalytic
B4U37_14540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B4U37_14545	COG0006	proline dipeptidase activity
B4U37_14550	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B4U37_14560	COG3872	metal-dependent enzyme
B4U37_14570	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4U37_14575	COG1321	iron dependent repressor
B4U37_14595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U37_14605	COG0095	Lipoate-protein ligase
B4U37_14610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U37_14625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4U37_14630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B4U37_14635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4U37_14660	COG3708	Transcriptional regulator
B4U37_14660	COG2207	Transcriptional regulator
B4U37_14680	COG2140	Oxalate decarboxylase
B4U37_14690	COG0681	Belongs to the peptidase S26 family
B4U37_14710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U37_14745	COG4970	Tfp pilus assembly protein FimT
B4U37_14750	COG4537	Required for transformation and DNA binding
B4U37_14760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4U37_14770	COG4608	Belongs to the ABC transporter superfamily
B4U37_14775	COG0791	NLP P60 protein
B4U37_14780	COG4948	Mandelate Racemase Muconate Lactonizing
B4U37_14785	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4U37_14790	COG4166	transmembrane transport
B4U37_14795	COG0444	Belongs to the ABC transporter superfamily
B4U37_14800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U37_14805	COG0601	transmembrane transport
B4U37_14810	COG2362	D-Aminopeptidase
B4U37_14815	COG0693	protein deglycase activity
B4U37_14825	COG4191	Histidine kinase
B4U37_14860	COG1393	Belongs to the ArsC family
B4U37_14875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_14890	COG0011	TIGRFAM Protein of
B4U37_14905	COG1368	sulfuric ester hydrolase activity
B4U37_14910	COG1940	carbohydrate kinase activity
B4U37_14925	COG0697	spore germination
B4U37_14930	COG0457	Tetratricopeptide repeat
B4U37_14930	COG0705	Rhomboid family
B4U37_14935	COG0840	transmembrane signaling receptor activity
B4U37_14945	COG0039	L-malate dehydrogenase activity
B4U37_14955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4U37_14965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B4U37_15005	COG0604	alcohol dehydrogenase
B4U37_15010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4U37_15030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4U37_15035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4U37_15040	COG0640	Transcriptional regulator
B4U37_15045	COG0659	secondary active sulfate transmembrane transporter activity
B4U37_15050	COG0704	Plays a role in the regulation of phosphate uptake
B4U37_15055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4U37_15060	COG0581	inorganic phosphate transmembrane transporter activity
B4U37_15065	COG0573	inorganic phosphate transmembrane transporter activity
B4U37_15070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4U37_15080	COG0477	Major facilitator Superfamily
B4U37_15095	COG0205	6-phosphofructokinase activity
B4U37_15100	COG2839	Protein conserved in bacteria
B4U37_15105	COG1283	sodium-dependent phosphate transmembrane transporter activity
B4U37_15120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B4U37_15125	COG4709	membrane
B4U37_15130	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
B4U37_15135	COG0735	belongs to the Fur family
B4U37_15140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U37_15145	COG1121	(ABC) transporter
B4U37_15150	COG5002	protein histidine kinase activity
B4U37_15160	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B4U37_15175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B4U37_15180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B4U37_15185	COG2384	SAM-dependent methyltransferase
B4U37_15190	COG2010	Cytochrome c
B4U37_15200	COG1960	acyl-CoA dehydrogenase activity
B4U37_15210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4U37_15215	COG0358	DNA primase activity
B4U37_15220	COG1671	Belongs to the UPF0178 family
B4U37_15235	COG0517	IMP dehydrogenase activity
B4U37_15240	COG0751	glycine-tRNA ligase activity
B4U37_15245	COG0752	glycyl-tRNA synthetase alpha subunit
B4U37_15250	COG1381	Involved in DNA repair and RecF pathway recombination
B4U37_15260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B4U37_15265	COG0295	cytidine deaminase activity
B4U37_15270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B4U37_15280	COG1480	7TM receptor with intracellular HD hydrolase
B4U37_15285	COG1702	phosphate starvation-inducible protein PhoH
B4U37_15305	COG4864	UPF0365 protein
B4U37_15310	COG1030	water channel activity
B4U37_15315	COG1610	YqeY-like protein
B4U37_15320	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B4U37_15330	COG1283	sodium-dependent phosphate transmembrane transporter activity
B4U37_15335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B4U37_15340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4U37_15345	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4U37_15350	COG2264	protein methyltransferase activity
B4U37_15360	COG0443	Heat shock 70 kDa protein
B4U37_15365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B4U37_15375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4U37_15390	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_15405	COG1466	dna polymerase III delta subunit
B4U37_15415	COG0658	competence protein
B4U37_15415	COG2333	competence protein COMEC
B4U37_15420	COG2131	deaminase
B4U37_15425	COG1555	photosystem II stabilization
B4U37_15425	COG1596	polysaccharide export
B4U37_15430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U37_15435	COG2226	methyltransferase
B4U37_15440	COG0799	negative regulation of ribosome biogenesis
B4U37_15445	COG1713	HD superfamily hydrolase involved in NAD metabolism
B4U37_15450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B4U37_15455	COG1534	Rna-binding protein
B4U37_15460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B4U37_15465	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4U37_15470	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B4U37_15480	COG0688	phosphatidylethanolamine metabolic process
B4U37_15490	COG1191	sigma factor activity
B4U37_15510	COG1174	glycine betaine transport
B4U37_15515	COG0517	IMP dehydrogenase activity
B4U37_15515	COG1125	glycine betaine transport
B4U37_15520	COG1525	nuclease
B4U37_15530	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B4U37_15535	COG0626	cystathionine gamma-synthase activity
B4U37_15540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U37_15545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4U37_15570	COG0768	penicillin binding
B4U37_15575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4U37_15580	COG0572	uridine kinase
B4U37_15600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4U37_15605	COG1959	2 iron, 2 sulfur cluster binding
B4U37_15610	COG3906	Belongs to the UPF0473 family
B4U37_15615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B4U37_15620	COG4472	Bacterial protein of unknown function (DUF965)
B4U37_15625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4U37_15630	COG0628	permease
B4U37_15635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4U37_15640	COG1012	belongs to the aldehyde dehydrogenase family
B4U37_15645	COG3835	regulator
B4U37_15675	COG0493	'glutamate synthase
B4U37_15710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4U37_15720	COG0482	sulfurtransferase activity
B4U37_15725	COG1104	cysteine desulfurase activity
B4U37_15730	COG1959	2 iron, 2 sulfur cluster binding
B4U37_15735	COG2364	Membrane
B4U37_15740	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4U37_15750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4U37_15765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B4U37_15770	COG0124	histidyl-tRNA synthetase
B4U37_15780	COG4991	sh3 domain protein
B4U37_15780	COG3103	Sh3 type 3 domain protein
B4U37_15780	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_15785	COG1490	D-aminoacyl-tRNA deacylase activity
B4U37_15790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4U37_15800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4U37_15800	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B4U37_15805	COG5416	Lipopolysaccharide assembly protein A domain
B4U37_15810	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4U37_15815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U37_15815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U37_15825	COG2244	polysaccharide biosynthetic process
B4U37_15830	COG2323	membrane
B4U37_15840	COG1862	Preprotein translocase
B4U37_15850	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B4U37_15860	COG2255	four-way junction helicase activity
B4U37_15865	COG0632	four-way junction helicase activity
B4U37_15880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B4U37_15900	COG0157	Belongs to the NadC ModD family
B4U37_15905	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B4U37_15910	COG1104	cysteine desulfurase activity
B4U37_15915	COG1827	regulation of RNA biosynthetic process
B4U37_15920	COG0077	Prephenate dehydratase
B4U37_15925	COG4492	Belongs to the UPF0735 family
B4U37_15930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B4U37_15935	COG3290	protein histidine kinase activity
B4U37_15945	COG2868	ribosomal protein
B4U37_15955	COG1530	ribonuclease E activity
B4U37_15960	COG1994	Peptidase M50
B4U37_15965	COG0739	heme binding
B4U37_15985	COG2894	cell division
B4U37_15990	COG0850	regulation of cytokinetic process
B4U37_15995	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B4U37_16000	COG1792	Involved in formation and maintenance of cell shape
B4U37_16005	COG1077	Cell shape determining protein MreB Mrl
B4U37_16010	COG2003	Belongs to the UPF0758 family
B4U37_16040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4U37_16050	COG1459	type II secretion system
B4U37_16075	COG1595	DNA-templated transcription, initiation
B4U37_16085	COG3706	GGDEF domain
B4U37_16085	COG0745	RESPONSE REGULATOR receiver
B4U37_16090	COG0285	dihydrofolate synthase activity
B4U37_16105	COG0189	ligase activity
B4U37_16115	COG0285	dihydrofolate synthase activity
B4U37_16125	COG0525	valine-tRNA ligase activity
B4U37_16135	COG0840	transmembrane signaling receptor activity
B4U37_16140	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4U37_16145	COG1388	LysM domain
B4U37_16150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4U37_16155	COG0113	porphobilinogen synthase activity
B4U37_16165	COG0181	hydroxymethylbilane synthase activity
B4U37_16170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4U37_16185	COG1126	abc transporter atp-binding protein
B4U37_16190	COG0765	amino acid transport
B4U37_16205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B4U37_16210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B4U37_16215	COG1067	ATP-dependent peptidase activity
B4U37_16215	COG0470	DNA polymerase III
B4U37_16225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B4U37_16230	COG0544	peptidyl-prolyl cis-trans isomerase activity
B4U37_16235	COG0457	Tetratricopeptide repeat
B4U37_16235	COG1477	protein flavinylation
B4U37_16250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B4U37_16255	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B4U37_16260	COG5401	PFAM Sporulation and spore germination
B4U37_16270	COG2197	response regulator
B4U37_16275	COG0824	Thioesterase
B4U37_16280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4U37_16285	COG1053	succinate dehydrogenase
B4U37_16290	COG2009	succinate dehydrogenase
B4U37_16295	COG1719	4-vinyl reductase, 4VR
B4U37_16310	COG0322	excinuclease ABC activity
B4U37_16315	COG3118	belongs to the thioredoxin family
B4U37_16325	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B4U37_16330	COG2086	electron transfer activity
B4U37_16335	COG1024	Enoyl-CoA hydratase
B4U37_16340	COG1309	transcriptional regulator
B4U37_16345	COG0318	PFAM AMP-dependent synthetase and ligase
B4U37_16360	COG3766	membrane
B4U37_16370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4U37_16370	COG1796	DNA polymerase
B4U37_16375	COG1286	toxin biosynthetic process
B4U37_16380	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B4U37_16385	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B4U37_16390	COG0072	phenylalanine-tRNA ligase activity
B4U37_16390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U37_16395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B4U37_16400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4U37_16415	COG1363	Peptidase, m42
B4U37_16445	COG1404	Belongs to the peptidase S8 family
B4U37_16460	COG0681	Belongs to the peptidase S26 family
B4U37_16470	COG1404	Belongs to the peptidase S8 family
B4U37_16475	COG1404	Belongs to the peptidase S8 family
B4U37_16480	COG1404	Belongs to the peptidase S8 family
B4U37_16485	COG1404	Belongs to the peptidase S8 family
B4U37_16490	COG0398	Pfam SNARE associated Golgi protein
B4U37_16495	COG3326	Membrane
B4U37_16505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B4U37_16510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B4U37_16515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4U37_16525	COG1597	lipid kinase activity
B4U37_16530	COG3611	Membrane attachment protein
B4U37_16535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B4U37_16545	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B4U37_16550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4U37_16560	COG1971	Probably functions as a manganese efflux pump
B4U37_16570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B4U37_16575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U37_16575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U37_16580	COG0330	HflC and HflK could
B4U37_16590	COG5002	protein histidine kinase activity
B4U37_16595	COG0745	RESPONSE REGULATOR receiver
B4U37_16605	COG0039	L-malate dehydrogenase activity
B4U37_16610	COG0538	isocitrate dehydrogenase activity
B4U37_16615	COG0372	Belongs to the citrate synthase family
B4U37_16620	COG2707	UPF0756 membrane protein
B4U37_16625	COG0628	permease
B4U37_16645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4U37_16685	COG4974	Belongs to the 'phage' integrase family
B4U37_16720	COG3344	reverse transcriptase
B4U37_16730	COG4086	secreted protein
B4U37_16735	COG3030	protein affecting phage T7 exclusion by the F plasmid
B4U37_16745	COG0205	6-phosphofructokinase activity
B4U37_16750	COG0825	malonyl-CoA metabolic process
B4U37_16755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B4U37_16760	COG2186	Transcriptional regulator
B4U37_16765	COG0281	malic enzyme
B4U37_16770	COG0587	DNA-directed DNA polymerase activity
B4U37_16785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4U37_16800	COG4109	DRTGG domain
B4U37_16815	COG0006	proline dipeptidase activity
B4U37_16825	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_16845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B4U37_16850	COG0827	DNA restriction-modification system
B4U37_16855	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B4U37_16860	COG3874	Sporulation protein YtfJ
B4U37_16870	COG1714	RDD family
B4U37_16875	COG0616	signal peptide processing
B4U37_16880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4U37_16885	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B4U37_16890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4U37_16900	COG0301	tRNA thio-modification
B4U37_16905	COG1104	cysteine desulfurase activity
B4U37_16910	COG1114	Component of the transport system for branched-chain amino acids
B4U37_16920	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B4U37_16925	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4U37_16930	COG1309	transcriptional regulator
B4U37_16935	COG1956	GAF domain-containing protein
B4U37_16940	COG0626	cystathionine gamma-synthase activity
B4U37_16945	COG2199	diguanylate cyclase activity
B4U37_16945	COG2203	Gaf domain
B4U37_16955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B4U37_16960	COG0456	acetyltransferase
B4U37_16965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4U37_16980	COG2814	Major facilitator Superfamily
B4U37_16985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4U37_16990	COG0454	-acetyltransferase
B4U37_16995	COG0517	IMP dehydrogenase activity
B4U37_17000	COG0123	including yeast histone deacetylase and acetoin utilization protein
B4U37_17010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4U37_17020	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B4U37_17020	COG1605	Chorismate mutase
B4U37_17025	COG0849	cell division
B4U37_17030	COG3118	belongs to the thioredoxin family
B4U37_17035	COG4980	gas vesicle protein
B4U37_17040	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B4U37_17045	COG2309	aminopeptidase activity
B4U37_17050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4U37_17060	COG1674	ftsk spoiiie
B4U37_17060	COG1674	ftsk spoiiie
B4U37_17065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U37_17070	COG4848	Belongs to the UPF0354 family
B4U37_17075	COG1404	Belongs to the peptidase S8 family
B4U37_17075	COG4412	M6 family metalloprotease domain protein
B4U37_17080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_17090	COG0840	transmembrane signaling receptor activity
B4U37_17110	COG1363	Peptidase, m42
B4U37_17120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_17125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B4U37_17135	COG0510	thiamine kinase activity
B4U37_17140	COG1523	belongs to the glycosyl hydrolase 13 family
B4U37_17150	COG1346	cytolysis
B4U37_17155	COG1380	Effector of murein hydrolase LrgA
B4U37_17165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U37_17175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U37_17185	COG1131	(ABC) transporter
B4U37_17190	COG1349	DNA-binding transcription factor activity
B4U37_17195	COG1187	pseudouridine synthase activity
B4U37_17200	COG2244	polysaccharide biosynthetic process
B4U37_17210	COG2081	HI0933 family
B4U37_17240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U37_17245	COG0495	leucyl-tRNA aminoacylation
B4U37_17255	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_17260	COG2610	gluconate transmembrane transporter activity
B4U37_17265	COG3829	transcription factor binding
B4U37_17265	COG3290	protein histidine kinase activity
B4U37_17350	COG0326	Molecular chaperone. Has ATPase activity
B4U37_17355	COG2814	Major facilitator Superfamily
B4U37_17370	COG1242	4 iron, 4 sulfur cluster binding
B4U37_17375	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B4U37_17385	COG2267	carboxylic ester hydrolase activity
B4U37_17390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B4U37_17395	COG0671	phosphoesterase, PA-phosphatase related
B4U37_17400	COG0438	transferase activity, transferring glycosyl groups
B4U37_17410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B4U37_17420	COG1506	peptidase
B4U37_17425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4U37_17430	COG1116	anion transmembrane transporter activity
B4U37_17435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4U37_17440	COG0494	nUDIX hydrolase
B4U37_17450	COG4824	toxin secretion phage lysis holin
B4U37_17460	COG0783	Belongs to the Dps family
B4U37_17475	COG0701	Predicted permease
B4U37_17485	COG1854	S-ribosylhomocysteine lyase activity
B4U37_17490	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B4U37_17495	COG0288	reversible hydration of carbon dioxide
B4U37_17500	COG0523	cobalamin synthesis protein
B4U37_17515	COG1271	oxidase subunit
B4U37_17520	COG1294	oxidase, subunit
B4U37_17535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U37_17540	COG1321	iron dependent repressor
B4U37_17540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U37_17545	COG1121	(ABC) transporter
B4U37_17550	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4U37_17555	COG4948	Mandelate Racemase Muconate Lactonizing
B4U37_17565	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B4U37_17570	COG0596	Alpha beta hydrolase
B4U37_17575	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B4U37_17580	COG1169	isochorismate synthase
B4U37_17585	COG1575	Belongs to the MenA family. Type 1 subfamily
B4U37_17590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4U37_17605	COG0058	SHG alpha-glucan phosphorylase activity
B4U37_17610	COG0297	glycogen (starch) synthase activity
B4U37_17615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B4U37_17755	COG3859	Proton-coupled thiamine transporter YuaJ
B4U37_17765	COG0697	spore germination
B4U37_17770	COG1285	pathogenesis
B4U37_17785	COG1215	transferase activity, transferring glycosyl groups
B4U37_17815	COG0489	protein tyrosine kinase activity
B4U37_17840	COG2197	response regulator
B4U37_17845	COG4585	Histidine kinase
B4U37_17855	COG1842	Phage shock protein A
B4U37_17870	COG1404	Belongs to the peptidase S8 family
B4U37_17880	COG2132	Multicopper oxidase
B4U37_17890	COG0513	Belongs to the DEAD box helicase family
B4U37_17895	COG1408	metallophosphoesterase
B4U37_17900	COG2814	Major facilitator Superfamily
B4U37_17920	COG3279	Response regulator of the LytR AlgR family
B4U37_17925	COG2205	protein histidine kinase activity
B4U37_17930	COG3243	poly(R)-hydroxyalkanoic acid synthase
B4U37_17945	COG1278	Cold shock
B4U37_17970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4U37_17990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4U37_17990	COG2111	Na H antiporter
B4U37_17995	COG2111	Na H antiporter
B4U37_18000	COG1006	Multisubunit Na H antiporter MnhC subunit
B4U37_18005	COG0651	ATP synthesis coupled electron transport
B4U37_18010	COG1863	multisubunit Na H antiporter MnhE subunit
B4U37_18015	COG2212	antiporter activity
B4U37_18020	COG1320	monovalent cation:proton antiporter activity
B4U37_18025	COG1979	alcohol dehydrogenase
B4U37_18030	COG2155	Conserved Protein
B4U37_18035	COG1098	S1 RNA binding domain
B4U37_18045	COG0436	Aminotransferase
B4U37_18050	COG1522	sequence-specific DNA binding
B4U37_18055	COG2267	carboxylic ester hydrolase activity
B4U37_18065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B4U37_18075	COG2032	superoxide dismutase activity
B4U37_18085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4U37_18095	COG5018	Exonuclease
B4U37_18100	COG2814	Major facilitator Superfamily
B4U37_18110	COG2050	protein possibly involved in aromatic compounds catabolism
B4U37_18115	COG0640	Transcriptional regulator
B4U37_18130	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_18145	COG5520	Belongs to the glycosyl hydrolase 30 family
B4U37_18160	COG2723	6-phospho-beta-galactosidase activity
B4U37_18165	COG0395	ABC-type sugar transport system, permease component
B4U37_18180	COG1609	Transcriptional regulator
B4U37_18185	COG1131	(ABC) transporter
B4U37_18195	COG1595	DNA-templated transcription, initiation
B4U37_18205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B4U37_18210	COG0772	Belongs to the SEDS family
B4U37_18215	COG0772	Belongs to the SEDS family
B4U37_18225	COG1268	BioY protein
B4U37_18235	COG2056	Na+-H+ antiporter family
B4U37_18250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4U37_18255	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B4U37_18260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U37_18265	COG3584	3D domain protein
B4U37_18280	COG1252	NADH dehydrogenase
B4U37_18295	COG0316	Belongs to the HesB IscA family
B4U37_18300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B4U37_18305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4U37_18315	COG4844	belongs to the
B4U37_18320	COG1252	NADH dehydrogenase
B4U37_18325	COG4837	Protein of unknown function (DUF1462)
B4U37_18330	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4U37_18335	COG0083	homoserine kinase activity
B4U37_18340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4U37_18345	COG0460	homoserine dehydrogenase
B4U37_18350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U37_18355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4U37_18360	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4U37_18365	COG0647	UMP catabolic process
B4U37_18370	COG2445	Protein of unknown function DUF86
B4U37_18375	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B4U37_18390	COG4470	Protein conserved in bacteria
B4U37_18400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B4U37_18405	COG0739	heme binding
B4U37_18415	COG0733	neurotransmitter:sodium symporter activity
B4U37_18420	COG1757	Na H antiporter
B4U37_18440	COG3377	Domain of unknown function (DUF1805)
B4U37_18445	COG0737	Belongs to the 5'-nucleotidase family
B4U37_18450	COG1801	Protein of unknown function DUF72
B4U37_18480	COG3655	Transcriptional regulator
B4U37_18485	COG3739	integral membrane protein
B4U37_18490	COG0719	Fe-S assembly protein
B4U37_18495	COG0822	iron-sulfur transferase activity
B4U37_18500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4U37_18505	COG0719	Fe-S assembly protein
B4U37_18510	COG0396	ATPase activity
B4U37_18515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4U37_18520	COG1464	Belongs to the NlpA lipoprotein family
B4U37_18525	COG2011	ABC-type metal ion transport system permease component
B4U37_18530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4U37_18535	COG1597	lipid kinase activity
B4U37_18550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U37_18555	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4U37_18565	COG0509	glycine decarboxylation via glycine cleavage system
B4U37_18570	COG1393	Belongs to the ArsC family
B4U37_18575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4U37_18580	COG1960	acyl-CoA dehydrogenase activity
B4U37_18585	COG0183	Belongs to the thiolase family
B4U37_18590	COG1024	Enoyl-CoA hydratase
B4U37_18590	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U37_18610	COG5577	PFAM Coat F domain
B4U37_18630	COG1120	ATPase activity
B4U37_18635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_18640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_18645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U37_18650	COG1525	nuclease
B4U37_18650	COG0737	Belongs to the 5'-nucleotidase family
B4U37_18650	COG4085	toxin activity
B4U37_18655	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_18660	COG0750	zinc metalloprotease
B4U37_18665	COG0730	response to heat
B4U37_18670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U37_18670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U37_18675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U37_18675	COG0425	Belongs to the sulfur carrier protein TusA family
B4U37_18690	COG2210	Belongs to the sulfur carrier protein TusA family
B4U37_18695	COG0425	Belongs to the sulfur carrier protein TusA family
B4U37_18700	COG1937	Protein conserved in bacteria
B4U37_18720	COG0673	inositol 2-dehydrogenase activity
B4U37_18730	COG1609	Transcriptional regulator
B4U37_18735	COG0673	inositol 2-dehydrogenase activity
B4U37_18740	COG3459	Glycosyltransferase 36 associated
B4U37_18745	COG1472	Belongs to the glycosyl hydrolase 3 family
B4U37_18750	COG0395	ABC-type sugar transport system, permease component
B4U37_18755	COG1175	transmembrane transport
B4U37_18770	COG0395	ABC-type sugar transport system, permease component
B4U37_18775	COG1175	transmembrane transport
B4U37_18805	COG1028	Short-chain dehydrogenase reductase Sdr
B4U37_18810	COG5002	protein histidine kinase activity
B4U37_18820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B4U37_18825	COG0557	exoribonuclease II activity
B4U37_18830	COG1647	Serine aminopeptidase, S33
B4U37_18855	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4U37_18860	COG0148	phosphopyruvate hydratase activity
B4U37_18865	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B4U37_18885	COG2390	Transcriptional regulator
B4U37_18895	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B4U37_18910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U37_18915	COG1481	regulation of sporulation
B4U37_18920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B4U37_18925	COG1660	Displays ATPase and GTPase activities
B4U37_18930	COG1051	belongs to the nudix hydrolase family
B4U37_18935	COG0492	ferredoxin-NADP+ reductase activity
B4U37_18940	COG0457	Tetratricopeptide repeat
B4U37_18945	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B4U37_18945	COG0140	phosphoribosyl-ATP diphosphatase activity
B4U37_18950	COG0107	imidazoleglycerol-phosphate synthase activity
B4U37_18960	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B4U37_18965	COG0131	Imidazoleglycerol-phosphate dehydratase
B4U37_18975	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B4U37_18980	COG0110	maltose O-acetyltransferase activity
B4U37_18985	COG0546	phosphoglycolate phosphatase activity
B4U37_18990	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B4U37_19000	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B4U37_19010	COG1950	PFAM Membrane protein of
B4U37_19020	COG3595	metallopeptidase activity
B4U37_19030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4U37_19035	COG0556	nucleotide-excision repair
B4U37_19045	COG4897	Protein conserved in bacteria
B4U37_19055	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B4U37_19075	COG1070	Carbohydrate kinase
B4U37_19080	COG2610	gluconate transmembrane transporter activity
B4U37_19085	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4U37_19090	COG1737	Transcriptional regulator
B4U37_19100	COG0586	Pfam SNARE associated Golgi protein
B4U37_19115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U37_19120	COG0793	Belongs to the peptidase S41A family
B4U37_19120	COG3409	Peptidoglycan-binding domain 1 protein
B4U37_19125	COG0739	heme binding
B4U37_19130	COG2177	Part of the ABC transporter FtsEX involved in
B4U37_19135	COG2884	Cell division ATP-binding protein ftsE
B4U37_19140	COG1404	Belongs to the peptidase S8 family
B4U37_19145	COG2010	Cytochrome c
B4U37_19150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U37_19155	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B4U37_19160	COG0653	protein targeting
B4U37_19165	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_19165	COG2247	cell wall binding repeat
B4U37_19175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B4U37_19190	COG1516	flagellar protein fliS
B4U37_19195	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B4U37_19200	COG1334	flagellar protein FlaG
B4U37_19235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4U37_19240	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B4U37_19245	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B4U37_19255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4U37_19260	COG1256	bacterial-type flagellum assembly
B4U37_19260	COG4786	Flagellar basal body rod
B4U37_19280	COG1040	competence protein
B4U37_19285	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B4U37_19290	COG1307	EDD domain protein, DegV family
B4U37_19295	COG2197	response regulator
B4U37_19300	COG4585	Histidine kinase
B4U37_19305	COG1739	Uncharacterized protein family UPF0029
B4U37_19310	COG1316	TRANSCRIPTIONal
B4U37_19315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4U37_19320	COG1215	transferase activity, transferring glycosyl groups
B4U37_19335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4U37_19340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4U37_19380	COG2385	sporulation resulting in formation of a cellular spore
B4U37_19380	COG2247	cell wall binding repeat
B4U37_19390	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_19420	COG1388	LysM domain
B4U37_19420	COG0791	NLP P60 protein
B4U37_19425	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_19425	COG2247	cell wall binding repeat
B4U37_19435	COG2247	cell wall binding repeat
B4U37_19435	COG2385	sporulation resulting in formation of a cellular spore
B4U37_19440	COG2340	Cysteine-rich secretory protein family
B4U37_19455	COG1134	teichoic acid transport
B4U37_19460	COG1682	transport, permease protein
B4U37_19465	COG2918	glutathione biosynthetic process
B4U37_19465	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U37_19475	COG2918	glutathione biosynthetic process
B4U37_19475	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U37_19485	COG1215	transferase activity, transferring glycosyl groups
B4U37_19490	COG1215	transferase activity, transferring glycosyl groups
B4U37_19500	COG0438	transferase activity, transferring glycosyl groups
B4U37_19515	COG1316	TRANSCRIPTIONal
B4U37_19520	COG4464	protein tyrosine phosphatase activity
B4U37_19525	COG3764	Sortase (surface protein transpeptidase)
B4U37_19535	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_19550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4U37_19595	COG1266	CAAX protease self-immunity
B4U37_19605	COG0745	RESPONSE REGULATOR receiver
B4U37_19610	COG2814	Major facilitator Superfamily
B4U37_19615	COG3344	reverse transcriptase
B4U37_19675	COG3764	Sortase (surface protein transpeptidase)
B4U37_19685	COG3012	SEC-C Motif Domain Protein
B4U37_19685	COG1405	negative regulation of cell septum assembly
B4U37_19710	COG0673	inositol 2-dehydrogenase activity
B4U37_19720	COG2972	Histidine kinase
B4U37_19745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4U37_19755	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
B4U37_19760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B4U37_19770	COG0697	spore germination
B4U37_19775	COG0366	Alpha amylase catalytic
B4U37_19775	COG1874	Beta-galactosidase
B4U37_19785	COG0346	lactoylglutathione lyase activity
B4U37_19820	COG2962	Rard protein
B4U37_19835	COG0463	Glycosyl transferase, family 2
B4U37_19850	COG1595	DNA-templated transcription, initiation
B4U37_19875	COG0861	Integral membrane protein TerC family
B4U37_19880	COG0697	spore germination
B4U37_19885	COG0697	spore germination
B4U37_19890	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4U37_19905	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B4U37_19910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4U37_19915	COG1309	transcriptional regulator
B4U37_19930	COG0861	Integral membrane protein TerC family
B4U37_19945	COG5444	nuclease activity
B4U37_19955	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U37_19955	COG2247	cell wall binding repeat
B4U37_19965	COG0464	growth
B4U37_19990	COG1609	Transcriptional regulator
B4U37_20010	COG0395	ABC-type sugar transport system, permease component
B4U37_20015	COG4209	transmembrane transport
B4U37_20020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U37_20080	COG1216	Glycosyl transferase, family 2
B4U37_20080	COG0463	Glycosyl transferase, family 2
B4U37_20085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4U37_20105	COG0110	maltose O-acetyltransferase activity
B4U37_20110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4U37_20115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4U37_20125	COG1086	Polysaccharide biosynthesis protein
B4U37_20130	COG0489	protein tyrosine kinase activity
B4U37_20135	COG3944	biosynthesis protein
B4U37_20160	COG4786	Flagellar basal body rod
B4U37_20165	COG4786	Flagellar basal body rod
B4U37_20180	COG1077	Cell shape determining protein MreB Mrl
B4U37_20185	COG1609	Transcriptional regulator
B4U37_20200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B4U37_20205	COG5002	protein histidine kinase activity
B4U37_20205	COG2176	DNA-directed DNA polymerase activity
B4U37_20215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U37_20235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4U37_20240	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B4U37_20245	COG2059	Chromate
B4U37_20250	COG2059	Chromate
B4U37_20255	COG0405	Gamma-glutamyltransferase
B4U37_20270	COG0739	heme binding
B4U37_20275	COG2385	sporulation resulting in formation of a cellular spore
B4U37_20280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4U37_20290	COG4836	Membrane
B4U37_20295	COG1007	ATP synthesis coupled electron transport
B4U37_20300	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U37_20305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4U37_20310	COG0713	ATP synthesis coupled electron transport
B4U37_20315	COG0839	Belongs to the complex I subunit 6 family
B4U37_20335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U37_20340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4U37_20355	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B4U37_20360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B4U37_20365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B4U37_20370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4U37_20380	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4U37_20405	COG1404	Belongs to the peptidase S8 family
B4U37_20410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B4U37_20425	COG0698	ribose 5-phosphate isomerase
B4U37_20430	COG0840	transmembrane signaling receptor activity
B4U37_20440	COG1971	Probably functions as a manganese efflux pump
B4U37_20445	COG0009	L-threonylcarbamoyladenylate synthase
B4U37_20465	COG2890	protein-(glutamine-N5) methyltransferase activity
B4U37_20480	COG1435	thymidine kinase activity
B4U37_20490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4U37_20500	COG1494	fructose-1,6-bisphosphatase
B4U37_20505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4U37_20510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4U37_20515	COG0191	fructose-bisphosphate aldolase activity
B4U37_20520	COG2204	response regulator
B4U37_20525	COG4821	SIS domain
B4U37_20540	COG0504	CTP synthase activity
B4U37_20545	COG3343	RNA polymerase activity
B4U37_20550	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U37_20550	COG1703	isobutyryl-CoA mutase activity
B4U37_20550	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B4U37_20555	COG3226	Transcriptional regulator
B4U37_20560	COG1960	acyl-CoA dehydrogenase activity
B4U37_20565	COG1960	acyl-CoA dehydrogenase activity
B4U37_20570	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U37_20575	COG0183	Belongs to the thiolase family
B4U37_20580	COG0247	lactate metabolic process
B4U37_20580	COG2181	nitrate reductase activity
B4U37_20585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4U37_20590	COG4294	response to UV
B4U37_20600	COG0018	arginyl-trna synthetase
B4U37_20610	COG0010	Belongs to the arginase family
B4U37_20615	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B4U37_20620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U37_20635	COG4325	translation initiation factor activity
B4U37_20640	COG3465	dGTPase activity
B4U37_20645	COG1078	dGTPase activity
B4U37_20650	COG4844	belongs to the
B4U37_20665	COG0280	phosphate acetyltransferase
B4U37_20680	COG2363	Small membrane protein
B4U37_20695	COG2322	membrane
B4U37_20705	COG0840	transmembrane signaling receptor activity
B4U37_20715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B4U37_20720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4U37_20725	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B4U37_20730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B4U37_20745	COG2261	transglycosylase associated protein
B4U37_20760	COG0778	Nitroreductase
B4U37_20770	COG1511	domain protein
B4U37_20770	COG0842	Transport permease protein
B4U37_20775	COG1131	(ABC) transporter
B4U37_20780	COG2031	fatty acid transporter
B4U37_20795	COG1621	beta-fructofuranosidase activity
B4U37_20800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U37_20805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U37_20805	COG1263	PTS System
B4U37_20810	COG3711	transcriptional antiterminator
B4U37_20815	COG2190	(PTS) system
B4U37_20820	COG3153	acetyltransferase
B4U37_20820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4U37_20830	COG0561	phosphatase activity
B4U37_20860	COG1263	PTS System
B4U37_20860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U37_20860	COG2190	(PTS) system
B4U37_20875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4U37_20875	COG0551	DNA topoisomerase type I activity
B4U37_20880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U37_20885	COG3480	Lon protease (S16) C-terminal proteolytic domain
B4U37_20890	COG0488	(ABC) transporter
B4U37_20895	COG3546	catalase activity
B4U37_20920	COG2205	protein histidine kinase activity
B4U37_20925	COG0745	RESPONSE REGULATOR receiver
B4U37_20935	COG1131	(ABC) transporter
B4U37_20940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4U37_20960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B4U37_20975	COG2267	carboxylic ester hydrolase activity
B4U37_20990	COG0604	alcohol dehydrogenase
B4U37_20990	COG3321	synthase
B4U37_21020	COG1653	transport
B4U37_21025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4U37_21030	COG1737	Transcriptional regulator
B4U37_21040	COG4977	sequence-specific DNA binding
B4U37_21050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B4U37_21055	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
B4U37_21060	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
B4U37_21070	COG0698	ribose 5-phosphate isomerase
B4U37_21075	COG0149	triose-phosphate isomerase activity
B4U37_21080	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
B4U37_21100	COG4869	propanediol catabolic process
B4U37_21105	COG2390	Transcriptional regulator
B4U37_21130	COG1744	ABC transporter substrate-binding protein PnrA-like
B4U37_21135	COG1187	pseudouridine synthase activity
B4U37_21140	COG3842	ATPase activity
B4U37_21145	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4U37_21155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B4U37_21160	COG0745	RESPONSE REGULATOR receiver
B4U37_21165	COG2205	protein histidine kinase activity
B4U37_21170	COG1136	(ABC) transporter
B4U37_21175	COG0577	efflux transmembrane transporter activity
B4U37_21180	COG1120	ATPase activity
B4U37_21185	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4U37_21190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_21195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U37_21225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4U37_21250	COG1984	allophanate hydrolase subunit 2
B4U37_21255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B4U37_21260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B4U37_21265	COG1914	H( )-stimulated, divalent metal cation uptake system
B4U37_21270	COG1307	EDD domain protein, DegV family
B4U37_21285	COG0579	oxidoreductase
B4U37_21290	COG4682	membrane
B4U37_21315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4U37_21320	COG3706	GGDEF domain
B4U37_21325	COG0697	spore germination
B4U37_21370	COG1304	FMN binding
B4U37_21380	COG2011	ABC-type metal ion transport system permease component
B4U37_21385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4U37_21395	COG0371	Dehydrogenase
B4U37_21415	COG2814	Major facilitator Superfamily
B4U37_21430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U37_21435	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B4U37_21440	COG4853	Protein conserved in bacteria
B4U37_21450	COG5002	protein histidine kinase activity
B4U37_21455	COG0745	RESPONSE REGULATOR receiver
B4U37_21460	COG1196	nuclear chromosome segregation
B4U37_21460	COG0739	heme binding
B4U37_21460	COG0741	lytic transglycosylase activity
B4U37_21485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B4U37_21490	COG0305	Participates in initiation and elongation during chromosome replication
B4U37_21495	COG0359	binds to the 23S rRNA
B4U37_21500	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B4U37_21505	COG4241	membrane
B4U37_21510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B4U37_21515	COG0629	single-stranded DNA binding
B4U37_21520	COG0360	Binds together with S18 to 16S ribosomal RNA
B4U37_21525	COG0012	GTP binding
B4U37_21530	COG4481	Protein conserved in bacteria
B4U37_21535	COG0668	transmembrane transport
B4U37_21540	COG3949	Membrane
B4U37_21550	COG1811	Na channel or pump
B4U37_21555	COG1475	DNA binding
B4U37_21560	COG1192	Involved in chromosome partitioning
B4U37_21565	COG1475	DNA binding
B4U37_21575	COG0445	tRNA wobble uridine modification
B4U37_21580	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B4U37_21585	COG1847	R3H domain protein
B4U37_21600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B4U37_21630	COG1131	(ABC) transporter
B4U37_21640	COG3279	Response regulator of the LytR AlgR family
B4U37_21670	COG1192	Involved in chromosome partitioning