locus-tag	class	description
M1M80_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M1M80_00010	COG0592	DNA-directed DNA polymerase activity
M1M80_00015	COG2501	S4 domain
M1M80_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M1M80_00030	COG0187	DNA topoisomerase II activity
M1M80_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M1M80_00070	COG0516	GMP reductase activity
M1M80_00070	COG0517	IMP dehydrogenase activity
M1M80_00075	COG1686	Belongs to the peptidase S11 family
M1M80_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M1M80_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M1M80_00100	COG1428	Deoxynucleoside kinase
M1M80_00105	COG1428	Deoxynucleoside kinase
M1M80_00110	COG1388	LysM domain
M1M80_00110	COG3858	chitin binding
M1M80_00115	COG1335	isochorismatase
M1M80_00120	COG0590	tRNA wobble adenosine to inosine editing
M1M80_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1M80_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M1M80_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1M80_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
M1M80_00190	COG3853	Toxic anion resistance protein (TelA)
M1M80_00195	COG1982	Orn Lys Arg decarboxylase major
M1M80_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M1M80_00205	COG3870	Protein conserved in bacteria
M1M80_00210	COG1728	Protein conserved in bacteria
M1M80_00215	COG0470	DNA polymerase III
M1M80_00220	COG1774	PSP1 C-terminal conserved region
M1M80_00225	COG4467	Involved in initiation control of chromosome replication
M1M80_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M1M80_00235	COG2827	Endonuclease containing a URI domain
M1M80_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M1M80_00245	COG2002	toxin-antitoxin pair type II binding
M1M80_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1M80_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1M80_00255	COG0084	hydrolase, TatD family'
M1M80_00260	COG3583	domain protein
M1M80_00260	COG3584	3D domain protein
M1M80_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M1M80_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1M80_00280	COG4466	Protein conserved in bacteria
M1M80_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M1M80_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M1M80_00300	COG0251	oxidation-reduction process
M1M80_00305	COG2088	sporulation resulting in formation of a cellular spore
M1M80_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M1M80_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1M80_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M1M80_00325	COG0193	aminoacyl-tRNA hydrolase activity
M1M80_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1M80_00340	COG2002	toxin-antitoxin pair type II binding
M1M80_00345	COG2244	polysaccharide biosynthetic process
M1M80_00350	COG3956	TIGRFAM MazG family protein
M1M80_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1M80_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1M80_00375	COG1098	S1 RNA binding domain
M1M80_00390	COG2208	phosphoserine phosphatase activity
M1M80_00395	COG2304	oxidoreductase activity
M1M80_00400	COG0515	serine threonine protein kinase
M1M80_00405	COG0037	tRNA processing
M1M80_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M1M80_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1M80_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M1M80_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1M80_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1M80_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1M80_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1M80_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
M1M80_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1M80_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1M80_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M1M80_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1M80_00470	COG1396	sequence-specific DNA binding
M1M80_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1M80_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M1M80_00560	COG4463	regulation of RNA biosynthetic process
M1M80_00565	COG3880	PFAM UvrB UvrC protein
M1M80_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
M1M80_00575	COG0542	response to heat
M1M80_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M1M80_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M1M80_00590	COG4956	integral membrane protein (PIN domain superfamily)
M1M80_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M1M80_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M1M80_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1M80_00610	COG1045	serine acetyltransferase
M1M80_00615	COG0215	cysteine-tRNA ligase activity
M1M80_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M1M80_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1M80_00630	COG3688	RNA-binding protein containing a PIN domain
M1M80_00635	COG1595	DNA-templated transcription, initiation
M1M80_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M1M80_00650	COG0250	Participates in transcription elongation, termination and antitermination
M1M80_00660	COG0081	regulation of translation
M1M80_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M1M80_00675	COG2813	Specifically methylates the guanine in position
M1M80_00680	COG0085	RNA polymerase activity
M1M80_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M1M80_00690	COG1358	cellular component organization or biogenesis
M1M80_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M1M80_00700	COG0049	tRNA binding
M1M80_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M1M80_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M1M80_00715	COG0596	Alpha beta hydrolase
M1M80_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M1M80_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M1M80_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M1M80_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M1M80_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M1M80_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M1M80_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M1M80_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M1M80_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M1M80_00820	COG0200	Binds to the 23S rRNA
M1M80_00825	COG0201	protein transport
M1M80_00830	COG0563	adenylate kinase activity
M1M80_00835	COG0024	Methionine aminopeptidase
M1M80_00845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M1M80_00850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M1M80_00855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M1M80_00860	COG0202	RNA polymerase activity
M1M80_00865	COG0203	ribosomal protein L17
M1M80_00870	COG1122	ATPase activity
M1M80_00875	COG1122	ATPase activity
M1M80_00880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M1M80_00885	COG0101	tRNA pseudouridine synthase activity
M1M80_00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M1M80_00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1M80_00900	COG2226	methyltransferase
M1M80_00910	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1M80_00915	COG0489	protein tyrosine kinase activity
M1M80_00925	COG2194	sulfuric ester hydrolase activity
M1M80_00930	COG0726	polysaccharide deacetylase
M1M80_01010	COG0738	Major facilitator superfamily
M1M80_01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1M80_01025	COG1063	alcohol dehydrogenase
M1M80_01030	COG0659	secondary active sulfate transmembrane transporter activity
M1M80_01035	COG0385	Bile acid
M1M80_01040	COG2819	hydrolase of the alpha beta superfamily
M1M80_01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1M80_01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1M80_01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1M80_01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1M80_01060	COG2207	Transcriptional regulator
M1M80_01065	COG3876	Protein conserved in bacteria
M1M80_01070	COG1472	Belongs to the glycosyl hydrolase 3 family
M1M80_01075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1M80_01080	COG1263	PTS System
M1M80_01080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_01085	COG1737	Transcriptional regulator
M1M80_01090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M1M80_01095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1M80_01100	COG1683	Conserved Protein
M1M80_01130	COG1595	DNA-templated transcription, initiation
M1M80_01135	COG5662	AntiSigma factor
M1M80_01140	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M1M80_01145	COG4856	YbbR-like protein
M1M80_01150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1M80_01160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1M80_01165	COG3002	Belongs to the UPF0753 family
M1M80_01170	COG0288	reversible hydration of carbon dioxide
M1M80_01180	COG5609	conserved protein (DUF2294)
M1M80_01185	COG0640	Transcriptional regulator
M1M80_01190	COG2814	Major facilitator Superfamily
M1M80_01195	COG1413	lyase activity
M1M80_01205	COG0789	Transcriptional regulator
M1M80_01210	COG0596	Alpha beta hydrolase
M1M80_01215	COG0745	RESPONSE REGULATOR receiver
M1M80_01220	COG0642	Histidine kinase
M1M80_01230	COG0515	serine threonine protein kinase
M1M80_01245	COG1113	amino acid transport
M1M80_01260	COG2602	Beta-lactamase
M1M80_01265	COG2124	cytochrome p450
M1M80_01275	COG0531	amino acid
M1M80_01280	COG1283	sodium-dependent phosphate transmembrane transporter activity
M1M80_01285	COG0584	glycerophosphoryl diester phosphodiesterase
M1M80_01290	COG2271	Major facilitator Superfamily
M1M80_01300	COG0456	acetyltransferase
M1M80_01300	COG1846	Transcriptional regulator
M1M80_01305	COG2271	Major facilitator Superfamily
M1M80_01320	COG0697	spore germination
M1M80_01325	COG1917	Cupin 2, conserved barrel domain protein
M1M80_01325	COG2207	Transcriptional regulator
M1M80_01330	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M1M80_01335	COG3591	Belongs to the peptidase S1B family
M1M80_01345	COG0596	Alpha beta hydrolase
M1M80_01350	COG1183	phosphatidylcholine synthase activity
M1M80_01355	COG0586	Pfam SNARE associated Golgi protein
M1M80_01360	COG0688	phosphatidylethanolamine metabolic process
M1M80_01370	COG2312	Erythromycin esterase
M1M80_01375	COG2207	Transcriptional regulator
M1M80_01380	COG1054	Belongs to the UPF0176 family
M1M80_01385	COG1301	dicarboxylic acid transport
M1M80_01390	COG2190	(PTS) system
M1M80_01390	COG1263	PTS System
M1M80_01390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_01395	COG0363	glucosamine-6-phosphate deaminase activity
M1M80_01400	COG2188	Transcriptional regulator
M1M80_01410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1M80_01415	COG0833	amino acid
M1M80_01420	COG2040	homocysteine
M1M80_01425	COG1115	amino acid carrier protein
M1M80_01430	COG2066	Belongs to the glutaminase family
M1M80_01435	COG4191	Histidine kinase
M1M80_01440	COG0784	Response regulator, receiver
M1M80_01445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1M80_01450	COG1012	belongs to the aldehyde dehydrogenase family
M1M80_01455	COG2271	Major facilitator Superfamily
M1M80_01460	COG4948	Mandelate Racemase Muconate Lactonizing
M1M80_01465	COG2186	Transcriptional regulator
M1M80_01470	COG2721	sulfolactate sulfo-lyase activity
M1M80_01475	COG3173	Aminoglycoside phosphotransferase
M1M80_01485	COG0697	spore germination
M1M80_01490	COG0745	RESPONSE REGULATOR receiver
M1M80_01495	COG2205	protein histidine kinase activity
M1M80_01500	COG1131	(ABC) transporter
M1M80_01525	COG3773	Cell wall hydrolase
M1M80_01530	COG2304	oxidoreductase activity
M1M80_01540	COG3540	Alkaline phosphatase
M1M80_01545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M1M80_01550	COG0805	protein transport
M1M80_01555	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M1M80_01560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1M80_01565	COG0477	Major facilitator Superfamily
M1M80_01570	COG1309	transcriptional regulator
M1M80_01575	COG0252	asparaginase activity
M1M80_01580	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M1M80_01585	COG1714	RDD family
M1M80_01590	COG1405	negative regulation of cell septum assembly
M1M80_01590	COG3012	SEC-C Motif Domain Protein
M1M80_01595	COG3290	protein histidine kinase activity
M1M80_01600	COG3279	Response regulator of the LytR AlgR family
M1M80_01605	COG4555	ABC transporter
M1M80_01610	COG1668	transmembrane transport
M1M80_01615	COG0667	Aldo Keto reductase
M1M80_01630	COG1595	DNA-templated transcription, initiation
M1M80_01635	COG1595	DNA-templated transcription, initiation
M1M80_01645	COG0457	Tetratricopeptide repeat
M1M80_01650	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_01655	COG0366	Alpha amylase catalytic
M1M80_01660	COG0803	Belongs to the bacterial solute-binding protein 9 family
M1M80_01665	COG1121	(ABC) transporter
M1M80_01670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1M80_01675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1M80_01680	COG2310	stress, protein
M1M80_01685	COG2310	stress, protein
M1M80_01690	COG2310	stress, protein
M1M80_01695	COG0861	Integral membrane protein TerC family
M1M80_01705	COG3853	Toxic anion resistance protein (TelA)
M1M80_01710	COG0477	Major facilitator Superfamily
M1M80_01715	COG2814	Major facilitator Superfamily
M1M80_01720	COG0640	Transcriptional regulator
M1M80_01725	COG4175	Glycine betaine
M1M80_01725	COG0517	IMP dehydrogenase activity
M1M80_01730	COG4176	ABC-type proline glycine betaine transport system permease component
M1M80_01735	COG2113	Glycine betaine
M1M80_01740	COG1473	amidohydrolase
M1M80_01745	COG1288	antiporter activity
M1M80_01755	COG0366	Alpha amylase catalytic
M1M80_01760	COG0039	L-malate dehydrogenase activity
M1M80_01765	COG1620	l-lactate permease
M1M80_01770	COG2814	Major facilitator Superfamily
M1M80_01775	COG1846	Transcriptional regulator
M1M80_01780	COG1280	lysine exporter protein (LysE YggA)
M1M80_01785	COG3403	YqcI/YcgG family
M1M80_01790	COG1113	amino acid transport
M1M80_01795	COG3665	Urea carboxylase-associated protein
M1M80_01800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1M80_01805	COG1660	Displays ATPase and GTPase activities
M1M80_01810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M1M80_01815	COG2226	methyltransferase
M1M80_01820	COG0583	DNA-binding transcription factor activity
M1M80_01825	COG3458	cephalosporin-C deacetylase activity
M1M80_01830	COG3541	Predicted nucleotidyltransferase
M1M80_01835	COG0506	proline dehydrogenase activity
M1M80_01840	COG1012	belongs to the aldehyde dehydrogenase family
M1M80_01845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1M80_01850	COG2508	Transcriptional regulator
M1M80_01855	COG3689	TIGRFAM TIGR03943 family protein
M1M80_01860	COG0701	Predicted permease
M1M80_01870	COG0492	ferredoxin-NADP+ reductase activity
M1M80_01875	COG1587	Uroporphyrinogen-III synthase
M1M80_01875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1M80_01880	COG2146	nitrite reductase [NAD(P)H] activity
M1M80_01885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1M80_01890	COG0243	molybdopterin cofactor binding
M1M80_01895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1M80_01900	COG2223	nitrite transmembrane transporter activity
M1M80_01905	COG1469	GTP cyclohydrolase I activity
M1M80_01910	COG1376	ErfK ybiS ycfS ynhG family protein
M1M80_01920	COG0523	cobalamin synthesis protein
M1M80_01925	COG0765	amino acid transport
M1M80_01930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1M80_01940	COG1714	RDD family
M1M80_01950	COG1846	Transcriptional regulator
M1M80_01960	COG3842	ATPase activity
M1M80_01965	COG2723	6-phospho-beta-galactosidase activity
M1M80_01975	COG3209	COG3209 Rhs family protein
M1M80_01980	COG0840	transmembrane signaling receptor activity
M1M80_01980	COG3290	protein histidine kinase activity
M1M80_01985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1M80_01990	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M1M80_01995	COG1733	regulation of RNA biosynthetic process
M1M80_02000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_02030	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1M80_02035	COG2814	Major facilitator Superfamily
M1M80_02045	COG0697	spore germination
M1M80_02050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1M80_02060	COG2364	Membrane
M1M80_02065	COG1126	abc transporter atp-binding protein
M1M80_02070	COG0765	amino acid transport
M1M80_02075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1M80_02080	COG0583	DNA-binding transcription factor activity
M1M80_02085	COG0163	prenyltransferase activity
M1M80_02090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M1M80_02105	COG0596	Alpha beta hydrolase
M1M80_02110	COG3104	oligopeptide transport
M1M80_02115	COG5434	Belongs to the glycosyl hydrolase 28 family
M1M80_02125	COG0697	spore germination
M1M80_02135	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1M80_02140	COG1136	(ABC) transporter
M1M80_02145	COG0577	efflux transmembrane transporter activity
M1M80_02150	COG0745	RESPONSE REGULATOR receiver
M1M80_02155	COG5002	protein histidine kinase activity
M1M80_02155	COG3850	Histidine kinase
M1M80_02160	COG0457	Tetratricopeptide repeat
M1M80_02175	COG0527	aspartate kinase activity
M1M80_02180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1M80_02185	COG4605	iron ion homeostasis
M1M80_02190	COG4604	ABC transporter, ATP-binding protein
M1M80_02195	COG4607	ABC-type enterochelin transport system periplasmic component
M1M80_02200	COG2814	Major facilitator Superfamily
M1M80_02205	COG1309	transcriptional regulator
M1M80_02210	COG0778	Nitroreductase
M1M80_02215	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1M80_02220	COG0640	Transcriptional regulator
M1M80_02225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1M80_02230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1M80_02235	COG1012	belongs to the aldehyde dehydrogenase family
M1M80_02240	COG4975	Glucose uptake
M1M80_02245	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_02250	COG4549	nuclear export factor GLE1
M1M80_02255	COG2372	response to copper ion
M1M80_02255	COG1276	copper resistance
M1M80_02260	COG1349	DNA-binding transcription factor activity
M1M80_02270	COG2213	PTS system mannitol-specific
M1M80_02275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1M80_02280	COG0246	Mannitol dehydrogenase
M1M80_02285	COG0473	3-isopropylmalate dehydrogenase activity
M1M80_02290	COG0412	Dienelactone hydrolase
M1M80_02295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M1M80_02305	COG0561	phosphatase activity
M1M80_02310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M1M80_02315	COG1914	H( )-stimulated, divalent metal cation uptake system
M1M80_02320	COG4336	lyase activity
M1M80_02325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M1M80_02330	COG1984	allophanate hydrolase subunit 2
M1M80_02335	COG1414	Transcriptional regulator
M1M80_02340	COG2755	lipolytic protein G-D-S-L family
M1M80_02350	COG2329	Antibiotic biosynthesis monooxygenase
M1M80_02355	COG0768	penicillin binding
M1M80_02360	COG4989	oxidoreductase activity
M1M80_02365	COG3711	transcriptional antiterminator
M1M80_02370	COG0318	PFAM AMP-dependent synthetase and ligase
M1M80_02375	COG2226	methyltransferase
M1M80_02380	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_02385	COG1917	Cupin 2, conserved barrel domain protein
M1M80_02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1M80_02395	COG3871	stress protein (general stress protein 26)
M1M80_02405	COG2814	Major facilitator Superfamily
M1M80_02410	COG1522	sequence-specific DNA binding
M1M80_02415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1M80_02415	COG0551	DNA topoisomerase type I activity
M1M80_02420	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M1M80_02425	COG3706	GGDEF domain
M1M80_02430	COG5298	Protein conserved in bacteria
M1M80_02435	COG1215	transferase activity, transferring glycosyl groups
M1M80_02445	COG0531	amino acid
M1M80_02455	COG0028	Belongs to the TPP enzyme family
M1M80_02465	COG1914	H( )-stimulated, divalent metal cation uptake system
M1M80_02470	COG2261	transglycosylase associated protein
M1M80_02475	COG4876	unkown
M1M80_02480	COG2217	Heavy metal translocating P-type atpase
M1M80_02485	COG3729	General stress protein
M1M80_02490	COG0662	Cupin 2, conserved barrel domain protein
M1M80_02495	COG2329	Antibiotic biosynthesis monooxygenase
M1M80_02500	COG3546	catalase activity
M1M80_02505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M1M80_02510	COG3290	protein histidine kinase activity
M1M80_02515	COG4565	transcriptional regulatory protein
M1M80_02520	COG1301	dicarboxylic acid transport
M1M80_02525	COG0628	permease
M1M80_02530	COG1301	dicarboxylic acid transport
M1M80_02535	COG1131	(ABC) transporter
M1M80_02540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M1M80_02550	COG1960	acyl-CoA dehydrogenase activity
M1M80_02565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M1M80_02570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1M80_02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
M1M80_02580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1M80_02585	COG0513	Belongs to the DEAD box helicase family
M1M80_02590	COG3402	PFAM membrane-flanked domain
M1M80_02595	COG3428	Bacterial PH domain
M1M80_02600	COG0705	Rhomboid family
M1M80_02605	COG0736	holo-[acyl-carrier-protein] synthase activity
M1M80_02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1M80_02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1M80_02620	COG0864	Transcriptional regulator
M1M80_02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
M1M80_02630	COG1366	Belongs to the anti-sigma-factor antagonist family
M1M80_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
M1M80_02640	COG2172	sigma factor antagonist activity
M1M80_02645	COG2208	phosphoserine phosphatase activity
M1M80_02650	COG1366	Belongs to the anti-sigma-factor antagonist family
M1M80_02655	COG2172	sigma factor antagonist activity
M1M80_02660	COG1191	sigma factor activity
M1M80_02665	COG2208	phosphoserine phosphatase activity
M1M80_02670	COG2183	response to ionizing radiation
M1M80_02680	COG3091	SprT-like family
M1M80_02735	COG1846	Transcriptional regulator
M1M80_02740	COG2070	2-Nitropropane dioxygenase
M1M80_02745	COG0431	NADPH-dependent FMN reductase
M1M80_02750	COG4978	Transcriptional regulator
M1M80_02750	COG0789	Transcriptional regulator
M1M80_02755	COG0702	epimerase
M1M80_02760	COG0697	spore germination
M1M80_02770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1M80_02775	COG0697	spore germination
M1M80_02795	COG1476	TRANSCRIPTIONal
M1M80_02820	COG2807	transmembrane transport
M1M80_02830	COG1278	Cold shock
M1M80_02835	COG1329	Transcriptional regulator
M1M80_02840	COG2207	Transcriptional regulator
M1M80_02840	COG3708	Transcriptional regulator
M1M80_02855	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
M1M80_02860	COG2814	Major facilitator Superfamily
M1M80_02875	COG1309	transcriptional regulator
M1M80_02880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1M80_02885	COG1316	TRANSCRIPTIONal
M1M80_02900	COG5002	protein histidine kinase activity
M1M80_02905	COG0745	RESPONSE REGULATOR receiver
M1M80_02910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1M80_02925	COG1114	Component of the transport system for branched-chain amino acids
M1M80_02930	COG0583	DNA-binding transcription factor activity
M1M80_02935	COG0114	fumarate hydratase activity
M1M80_02940	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M1M80_02945	COG1522	sequence-specific DNA binding
M1M80_02950	COG0697	spore germination
M1M80_02955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1M80_02960	COG2030	dehydratase
M1M80_02965	COG3545	Serine hydrolase
M1M80_02970	COG1733	regulation of RNA biosynthetic process
M1M80_02975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1M80_02985	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1M80_02990	COG0640	Transcriptional regulator
M1M80_02995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M1M80_03000	COG0789	Transcriptional regulator
M1M80_03005	COG0697	spore germination
M1M80_03010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1M80_03015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1M80_03020	COG0640	Transcriptional regulator
M1M80_03025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1M80_03040	COG4585	Histidine kinase
M1M80_03045	COG2197	response regulator
M1M80_03050	COG2409	Drug exporters of the RND superfamily
M1M80_03055	COG1811	Na channel or pump
M1M80_03060	COG4978	Transcriptional regulator
M1M80_03060	COG0789	Transcriptional regulator
M1M80_03065	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M1M80_03070	COG0778	Nitroreductase
M1M80_03075	COG0346	lactoylglutathione lyase activity
M1M80_03080	COG2259	Doxx family
M1M80_03085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1M80_03090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1M80_03100	COG1309	transcriptional regulator
M1M80_03110	COG0456	acetyltransferase
M1M80_03120	COG0673	inositol 2-dehydrogenase activity
M1M80_03125	COG1609	Transcriptional regulator
M1M80_03130	COG2814	Major facilitator Superfamily
M1M80_03135	COG1082	Xylose isomerase domain protein TIM barrel
M1M80_03145	COG0488	(ABC) transporter
M1M80_03150	COG1113	amino acid transport
M1M80_03155	COG2318	DinB family
M1M80_03160	COG1846	Transcriptional regulator
M1M80_03165	COG2409	Drug exporters of the RND superfamily
M1M80_03165	COG1033	growth of symbiont in host cell
M1M80_03175	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_03180	COG0778	Nitroreductase
M1M80_03185	COG1846	Transcriptional regulator
M1M80_03190	COG1396	sequence-specific DNA binding
M1M80_03205	COG2814	Major facilitator Superfamily
M1M80_03210	COG0730	response to heat
M1M80_03215	COG1802	Transcriptional regulator
M1M80_03220	COG3858	chitin binding
M1M80_03220	COG1388	LysM domain
M1M80_03225	COG1819	glycosyl
M1M80_03235	COG1785	Belongs to the alkaline phosphatase family
M1M80_03240	COG5646	InterPro IPR014922
M1M80_03250	COG0454	-acetyltransferase
M1M80_03255	COG1078	dGTPase activity
M1M80_03260	COG1388	LysM domain
M1M80_03265	COG2814	Major facilitator Superfamily
M1M80_03270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1M80_03275	COG1447	Phosphotransferase system cellobiose-specific component IIA
M1M80_03280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1M80_03285	COG2723	6-phospho-beta-galactosidase activity
M1M80_03290	COG2188	Transcriptional regulator
M1M80_03295	COG1940	carbohydrate kinase activity
M1M80_03300	COG1482	cell wall glycoprotein biosynthetic process
M1M80_03305	COG4124	Belongs to the glycosyl hydrolase 26 family
M1M80_03350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1M80_03355	COG0802	atpase or kinase
M1M80_03360	COG1214	PFAM Peptidase M22, glycoprotease
M1M80_03365	COG0456	acetyltransferase
M1M80_03370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M1M80_03375	COG0488	(ABC) transporter
M1M80_03380	COG0315	cyclic pyranopterin monophosphate synthase activity
M1M80_03385	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M1M80_03390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M1M80_03395	COG0805	protein transport
M1M80_03405	COG1266	CAAX protease self-immunity
M1M80_03415	COG0459	protein refolding
M1M80_03425	COG1073	alpha beta
M1M80_03430	COG0457	Tetratricopeptide repeat
M1M80_03435	COG1063	alcohol dehydrogenase
M1M80_03440	COG2211	Major facilitator Superfamily
M1M80_03445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1M80_03455	COG2814	Major facilitator Superfamily
M1M80_03460	COG1063	alcohol dehydrogenase
M1M80_03465	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1M80_03470	COG0823	Involved in the tonB-independent uptake of proteins
M1M80_03485	COG2267	carboxylic ester hydrolase activity
M1M80_03495	COG2132	Multicopper oxidase
M1M80_03500	COG1113	amino acid transport
M1M80_03505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M1M80_03510	COG0714	Associated with various cellular activities
M1M80_03515	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M1M80_03520	COG1305	Transglutaminase-like
M1M80_03525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1M80_03525	COG0519	Catalyzes the synthesis of GMP from XMP
M1M80_03540	COG2252	PERMEase
M1M80_03545	COG3064	Membrane
M1M80_03555	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M1M80_03565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M1M80_03570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1M80_03575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1M80_03580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M1M80_03585	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1M80_03590	COG0047	phosphoribosylformylglycinamidine synthase activity
M1M80_03595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1M80_03600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M1M80_03605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M1M80_03610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1M80_03615	COG0138	bifunctional purine biosynthesis protein purh
M1M80_03620	COG0151	Belongs to the GarS family
M1M80_03625	COG1522	sequence-specific DNA binding
M1M80_03630	COG0531	amino acid
M1M80_03640	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1M80_03645	COG1470	cell adhesion involved in biofilm formation
M1M80_03650	COG4496	protein, YerC YecD
M1M80_03655	COG0069	glutamate synthase activity
M1M80_03660	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M1M80_03665	COG0210	DNA helicase
M1M80_03670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M1M80_03675	COG4851	CamS sex pheromone cAM373 precursor
M1M80_03680	COG2814	Major facilitator Superfamily
M1M80_03700	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1M80_03705	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1M80_03720	COG1960	acyl-CoA dehydrogenase activity
M1M80_03750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1M80_03755	COG1785	Belongs to the alkaline phosphatase family
M1M80_03760	COG1285	pathogenesis
M1M80_03765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1M80_03770	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1M80_03775	COG0154	amidase activity
M1M80_03780	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1M80_03790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1M80_03795	COG1597	lipid kinase activity
M1M80_03800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M1M80_03855	COG3391	amine dehydrogenase activity
M1M80_03865	COG0457	Tetratricopeptide repeat
M1M80_03875	COG0217	transcriptional regulatory protein
M1M80_03885	COG1309	transcriptional regulator
M1M80_03890	COG3631	Ketosteroid isomerase-related protein
M1M80_03910	COG3546	catalase activity
M1M80_03915	COG0454	-acetyltransferase
M1M80_03925	COG5578	integral membrane protein
M1M80_03930	COG2972	Histidine kinase
M1M80_03935	COG2207	Transcriptional regulator
M1M80_03935	COG4753	response regulator
M1M80_03940	COG1653	transport
M1M80_03945	COG1175	transmembrane transport
M1M80_03950	COG0395	ABC-type sugar transport system, permease component
M1M80_03955	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M1M80_03960	COG2207	Transcriptional regulator
M1M80_03965	COG2755	lipolytic protein G-D-S-L family
M1M80_03975	COG5578	integral membrane protein
M1M80_03980	COG3401	FG-GAP repeat protein
M1M80_03985	COG3401	FG-GAP repeat protein
M1M80_03990	COG2755	lipolytic protein G-D-S-L family
M1M80_03995	COG1874	Beta-galactosidase
M1M80_04005	COG1653	transport
M1M80_04010	COG4209	transmembrane transport
M1M80_04015	COG0395	ABC-type sugar transport system, permease component
M1M80_04020	COG1486	melibiose metabolic process
M1M80_04025	COG2323	membrane
M1M80_04030	COG2329	Antibiotic biosynthesis monooxygenase
M1M80_04035	COG0346	lactoylglutathione lyase activity
M1M80_04045	COG1366	Belongs to the anti-sigma-factor antagonist family
M1M80_04050	COG5583	Uncharacterized small protein (DUF2292)
M1M80_04055	COG0670	Belongs to the BI1 family
M1M80_04060	COG0697	spore germination
M1M80_04065	COG1846	Transcriptional regulator
M1M80_04070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1M80_04085	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1M80_04085	COG2124	cytochrome p450
M1M80_04090	COG1368	sulfuric ester hydrolase activity
M1M80_04095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1M80_04100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1M80_04105	COG1442	glycosyl transferase family 8
M1M80_04110	COG1216	Glycosyl transferase, family 2
M1M80_04115	COG1442	glycosyl transferase family 8
M1M80_04120	COG2223	nitrite transmembrane transporter activity
M1M80_04125	COG1011	Hydrolase
M1M80_04130	COG0531	amino acid
M1M80_04135	COG1012	belongs to the aldehyde dehydrogenase family
M1M80_04140	COG0840	transmembrane signaling receptor activity
M1M80_04145	COG0488	(ABC) transporter
M1M80_04155	COG0789	Transcriptional regulator
M1M80_04160	COG2814	Major facilitator Superfamily
M1M80_04165	COG0488	(ABC) transporter
M1M80_04170	COG0513	Belongs to the DEAD box helicase family
M1M80_04175	COG0456	acetyltransferase
M1M80_04180	COG2130	NADP-dependent
M1M80_04185	COG1120	ATPase activity
M1M80_04190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1M80_04195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1M80_04200	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M1M80_04215	COG3866	Pectate lyase
M1M80_04220	COG0471	metal ion transport
M1M80_04225	COG3290	protein histidine kinase activity
M1M80_04230	COG4565	transcriptional regulatory protein
M1M80_04235	COG3181	Tripartite tricarboxylate transporter family receptor
M1M80_04240	COG2851	Citrate transporter
M1M80_04245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1M80_04250	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M1M80_04255	COG1254	Belongs to the acylphosphatase family
M1M80_04260	COG2258	MOSC domain
M1M80_04280	COG0024	Methionine aminopeptidase
M1M80_04285	COG1263	PTS System
M1M80_04285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_04290	COG1368	sulfuric ester hydrolase activity
M1M80_04300	COG1115	amino acid carrier protein
M1M80_04315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_04315	COG1263	PTS System
M1M80_04320	COG0366	Alpha amylase catalytic
M1M80_04325	COG2188	Transcriptional regulator
M1M80_04330	COG0778	Nitroreductase
M1M80_04340	COG0693	protein deglycase activity
M1M80_04345	COG2814	Major facilitator Superfamily
M1M80_04350	COG4840	Belongs to the UPF0435 family
M1M80_04355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1M80_04360	COG4980	gas vesicle protein
M1M80_04365	COG1295	ribonuclease BN
M1M80_04370	COG0477	Major facilitator Superfamily
M1M80_04375	COG0387	Pfam Sodium calcium exchanger
M1M80_04385	COG0668	transmembrane transport
M1M80_04390	COG0535	radical SAM domain protein
M1M80_04400	COG0726	polysaccharide deacetylase
M1M80_04405	COG2084	Dehydrogenase
M1M80_04410	COG0598	Magnesium transport protein CorA
M1M80_04415	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M1M80_04420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M1M80_04425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1M80_04435	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M1M80_04445	COG4637	Psort location Cytoplasmic, score
M1M80_04455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1M80_04460	COG0022	dehydrogenase e1 component
M1M80_04465	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1M80_04470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1M80_04475	COG3284	Transcriptional regulator
M1M80_04485	COG1742	UPF0060 membrane protein
M1M80_04505	COG4842	Belongs to the WXG100 family
M1M80_04510	COG1486	melibiose metabolic process
M1M80_04515	COG1737	Transcriptional regulator
M1M80_04520	COG1263	PTS System
M1M80_04520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_04525	COG1132	(ABC) transporter
M1M80_04530	COG1132	(ABC) transporter
M1M80_04535	COG2259	Doxx family
M1M80_04540	COG2514	catechol 2,3-dioxygenase activity
M1M80_04545	COG1917	Cupin 2, conserved barrel domain protein
M1M80_04545	COG4977	sequence-specific DNA binding
M1M80_04550	COG2814	Major facilitator Superfamily
M1M80_04555	COG1082	Xylose isomerase domain protein TIM barrel
M1M80_04560	COG0673	inositol 2-dehydrogenase activity
M1M80_04565	COG4585	Histidine kinase
M1M80_04570	COG2197	response regulator
M1M80_04575	COG1131	(ABC) transporter
M1M80_04580	COG1511	domain protein
M1M80_04580	COG0842	Transport permease protein
M1M80_04585	COG0842	Transport permease protein
M1M80_04595	COG1695	Transcriptional regulator
M1M80_04600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M1M80_04620	COG1131	(ABC) transporter
M1M80_04625	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
M1M80_04630	COG2318	DinB family
M1M80_04635	COG2814	Major facilitator Superfamily
M1M80_04640	COG1846	Transcriptional regulator
M1M80_04645	COG0392	lysyltransferase activity
M1M80_04645	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M1M80_04650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1M80_04655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1M80_04660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1M80_04665	COG0384	phenazine biosynthesis protein PhzF
M1M80_04670	COG0778	Nitroreductase
M1M80_04685	COG1090	epimerase
M1M80_04690	COG2137	regulation of response to DNA damage stimulus
M1M80_04700	COG2814	Major facilitator Superfamily
M1M80_04715	COG3103	Sh3 type 3 domain protein
M1M80_04720	COG5658	integral membrane protein
M1M80_04725	COG0596	Alpha beta hydrolase
M1M80_04730	COG0463	Glycosyl transferase, family 2
M1M80_04735	COG4485	Bacterial membrane protein, YfhO
M1M80_04740	COG1988	membrane-bound metal-dependent
M1M80_04745	COG1194	a g-specific adenine glycosylase
M1M80_04755	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_04770	COG3557	Belongs to the UPF0374 family
M1M80_04775	COG1132	(ABC) transporter
M1M80_04780	COG4129	membrane
M1M80_04785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M1M80_04790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1M80_04795	COG0735	belongs to the Fur family
M1M80_04915	COG0534	Mate efflux family protein
M1M80_04920	COG2226	methyltransferase
M1M80_04930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1M80_04930	COG2070	2-Nitropropane dioxygenase
M1M80_04935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1M80_04940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1M80_04950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1M80_04950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1M80_04950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_04950	COG3321	synthase
M1M80_04950	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_04960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1M80_04960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1M80_04960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_04960	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_04960	COG3321	synthase
M1M80_04965	COG3321	synthase
M1M80_04965	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_04965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1M80_04965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1M80_04965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_04980	COG3321	synthase
M1M80_04980	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_04980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_04980	COG0318	PFAM AMP-dependent synthetase and ligase
M1M80_04980	COG0300	oxidoreductase activity
M1M80_04985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1M80_04985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1M80_04985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_04985	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_04985	COG3321	synthase
M1M80_04990	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_04990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1M80_04990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_04990	COG3321	synthase
M1M80_04990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1M80_04995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1M80_05000	COG3425	synthase
M1M80_05005	COG1024	Enoyl-CoA hydratase
M1M80_05010	COG1024	Enoyl-CoA hydratase
M1M80_05015	COG1024	Enoyl-CoA hydratase
M1M80_05020	COG1082	Xylose isomerase domain protein TIM barrel
M1M80_05025	COG1819	glycosyl
M1M80_05055	COG4326	sporulation control protein
M1M80_05065	COG5577	PFAM Coat F domain
M1M80_05070	COG3340	Belongs to the peptidase S51 family
M1M80_05075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M1M80_05085	COG0753	catalase activity
M1M80_05090	COG1116	anion transmembrane transporter activity
M1M80_05095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1M80_05100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1M80_05105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1M80_05115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M1M80_05125	COG1476	TRANSCRIPTIONal
M1M80_05135	COG3382	B3 4 domain protein
M1M80_05140	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1M80_05150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1M80_05155	COG0789	Transcriptional regulator
M1M80_05160	COG1664	Polymer-forming cytoskeletal
M1M80_05165	COG1664	Polymer-forming cytoskeletal
M1M80_05170	COG2766	serine protein kinase
M1M80_05175	COG2718	Belongs to the UPF0229 family
M1M80_05180	COG1846	Transcriptional regulator
M1M80_05185	COG1566	PFAM secretion protein HlyD family protein
M1M80_05190	COG2814	Major facilitator Superfamily
M1M80_05195	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1M80_05210	COG1725	Transcriptional regulator
M1M80_05215	COG1131	(ABC) transporter
M1M80_05220	COG1131	(ABC) transporter
M1M80_05225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M1M80_05230	COG1278	Cold shock
M1M80_05235	COG1464	Belongs to the NlpA lipoprotein family
M1M80_05240	COG3706	GGDEF domain
M1M80_05245	COG1823	symporter activity
M1M80_05250	COG0456	acetyltransferase
M1M80_05260	COG1396	sequence-specific DNA binding
M1M80_05280	COG5577	PFAM Coat F domain
M1M80_05285	COG1525	nuclease
M1M80_05285	COG4085	toxin activity
M1M80_05285	COG0737	Belongs to the 5'-nucleotidase family
M1M80_05290	COG3764	Sortase (surface protein transpeptidase)
M1M80_05295	COG0564	pseudouridine synthase activity
M1M80_05305	COG0517	IMP dehydrogenase activity
M1M80_05310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1M80_05315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1M80_05315	COG3153	acetyltransferase
M1M80_05325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M1M80_05330	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M1M80_05335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M1M80_05340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1M80_05345	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M1M80_05350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1M80_05355	COG2203	Gaf domain
M1M80_05355	COG4585	Histidine kinase
M1M80_05360	COG2197	response regulator
M1M80_05365	COG0431	NADPH-dependent FMN reductase
M1M80_05380	COG0791	NLP P60 protein
M1M80_05380	COG1388	LysM domain
M1M80_05385	COG1959	2 iron, 2 sulfur cluster binding
M1M80_05395	COG2719	SpoVR family
M1M80_05400	COG1785	Belongs to the alkaline phosphatase family
M1M80_05405	COG0791	NLP P60 protein
M1M80_05405	COG1388	LysM domain
M1M80_05410	COG0583	DNA-binding transcription factor activity
M1M80_05415	COG0372	Belongs to the citrate synthase family
M1M80_05420	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_05425	COG0531	amino acid
M1M80_05430	COG0733	neurotransmitter:sodium symporter activity
M1M80_05435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1M80_05440	COG0456	acetyltransferase
M1M80_05455	COG1595	DNA-templated transcription, initiation
M1M80_05460	COG0667	Aldo Keto reductase
M1M80_05465	COG0204	Acyl-transferase
M1M80_05470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1M80_05480	COG1253	flavin adenine dinucleotide binding
M1M80_05485	COG0789	Transcriptional regulator
M1M80_05490	COG0436	Aminotransferase
M1M80_05495	COG1253	flavin adenine dinucleotide binding
M1M80_05500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M1M80_05505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M1M80_05510	COG0584	glycerophosphoryl diester phosphodiesterase
M1M80_05520	COG0668	transmembrane transport
M1M80_05525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1M80_05530	COG0726	polysaccharide deacetylase
M1M80_05535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1M80_05540	COG1757	Na H antiporter
M1M80_05545	COG0589	response to stress
M1M80_05555	COG1132	(ABC) transporter
M1M80_05560	COG1132	(ABC) transporter
M1M80_05565	COG0702	epimerase
M1M80_05585	COG0189	ligase activity
M1M80_05590	COG0189	ligase activity
M1M80_05595	COG4399	Belongs to the UPF0754 family
M1M80_05600	COG3679	Belongs to the UPF0342 family
M1M80_05605	COG4335	DNA alkylation repair
M1M80_05610	COG0561	phosphatase activity
M1M80_05615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1M80_05620	COG0475	glutathione-regulated potassium exporter activity
M1M80_05625	COG0490	domain, Protein
M1M80_05635	COG1024	Enoyl-CoA hydratase
M1M80_05645	COG4152	abc transporter atp-binding protein
M1M80_05650	COG1668	transmembrane transport
M1M80_05655	COG0420	3'-5' exonuclease activity
M1M80_05660	COG4717	serine-type aminopeptidase activity
M1M80_05665	COG3481	metal-dependent phosphohydrolase, HD sub domain
M1M80_05675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1M80_05700	COG1846	Transcriptional regulator
M1M80_05705	COG4980	gas vesicle protein
M1M80_05720	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M1M80_05725	COG0537	adenosine 5'-monophosphoramidase activity
M1M80_05730	COG1131	(ABC) transporter
M1M80_05735	COG4473	ABC transporter
M1M80_05745	COG1473	amidohydrolase
M1M80_05750	COG3069	C4-dicarboxylate transmembrane transporter activity
M1M80_05760	COG2329	Antibiotic biosynthesis monooxygenase
M1M80_05765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1M80_05770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M1M80_05775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M1M80_05780	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M1M80_05785	COG1309	transcriptional regulator
M1M80_05790	COG1511	domain protein
M1M80_05795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1M80_05800	COG4377	Putative membrane peptidase family (DUF2324)
M1M80_05810	COG1363	Peptidase, m42
M1M80_05815	COG4405	Protein conserved in bacteria
M1M80_05820	COG1301	dicarboxylic acid transport
M1M80_05830	COG1234	tRNA 3'-trailer cleavage
M1M80_05835	COG0095	Lipoate-protein ligase
M1M80_05840	COG0702	epimerase
M1M80_05845	COG0318	PFAM AMP-dependent synthetase and ligase
M1M80_05855	COG0501	Belongs to the peptidase M48B family
M1M80_05860	COG1404	Belongs to the peptidase S8 family
M1M80_05865	COG0456	acetyltransferase
M1M80_05870	COG0604	alcohol dehydrogenase
M1M80_05880	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M1M80_05885	COG0406	alpha-ribazole phosphatase activity
M1M80_05890	COG0183	Belongs to the thiolase family
M1M80_05895	COG0318	PFAM AMP-dependent synthetase and ligase
M1M80_05900	COG1268	BioY protein
M1M80_05905	COG0840	transmembrane signaling receptor activity
M1M80_05910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1M80_05910	COG0723	plastoquinol--plastocyanin reductase activity
M1M80_05915	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_05925	COG4903	ComK protein
M1M80_05930	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_05940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1M80_05955	COG0398	Pfam SNARE associated Golgi protein
M1M80_05960	COG0681	Belongs to the peptidase S26 family
M1M80_05965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1M80_05970	COG1846	Transcriptional regulator
M1M80_05980	COG3180	Ammonia monooxygenase
M1M80_05985	COG0477	Major facilitator Superfamily
M1M80_05985	COG2814	Major facilitator Superfamily
M1M80_05990	COG4533	DNA binding
M1M80_06000	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M1M80_06005	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M1M80_06010	COG1074	ATP-dependent DNA helicase activity
M1M80_06015	COG0420	3'-5' exonuclease activity
M1M80_06020	COG0419	ATPase involved in DNA repair
M1M80_06025	COG1403	HNH endonuclease
M1M80_06065	COG5337	Spore coat protein CotH
M1M80_06070	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1M80_06080	COG1404	Belongs to the peptidase S8 family
M1M80_06090	COG0367	asparagine synthase
M1M80_06100	COG0534	Mate efflux family protein
M1M80_06105	COG2207	Transcriptional regulator
M1M80_06105	COG1917	Cupin 2, conserved barrel domain protein
M1M80_06110	COG1609	Transcriptional regulator
M1M80_06115	COG0673	inositol 2-dehydrogenase activity
M1M80_06120	COG2318	DinB family
M1M80_06125	COG1279	arginine transmembrane transporter activity
M1M80_06130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1M80_06135	COG1357	PFAM Pentapeptide repeats (8 copies)
M1M80_06140	COG2267	carboxylic ester hydrolase activity
M1M80_06145	COG0529	Catalyzes the synthesis of activated sulfate
M1M80_06150	COG2046	Belongs to the sulfate adenylyltransferase family
M1M80_06155	COG0175	sulfate reduction
M1M80_06160	COG2045	Belongs to the ComB family
M1M80_06165	COG1809	phosphosulfolactate synthase activity
M1M80_06170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1M80_06175	COG4948	Mandelate Racemase Muconate Lactonizing
M1M80_06180	COG2814	Major facilitator Superfamily
M1M80_06185	COG0454	-acetyltransferase
M1M80_06190	COG2153	protein acetylation
M1M80_06195	COG0646	methionine synthase
M1M80_06195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1M80_06200	COG1666	GTP binding
M1M80_06225	COG1695	Transcriptional regulator
M1M80_06240	COG3227	Zinc metalloprotease (Elastase)
M1M80_06245	COG1307	EDD domain protein, DegV family
M1M80_06250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1M80_06270	COG0561	phosphatase activity
M1M80_06275	COG1073	alpha beta
M1M80_06280	COG2151	metal-sulfur cluster biosynthetic enzyme
M1M80_06290	COG0277	FAD linked oxidase domain protein
M1M80_06295	COG2271	Major facilitator Superfamily
M1M80_06300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M1M80_06305	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1M80_06315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1M80_06320	COG0505	Belongs to the CarA family
M1M80_06325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M1M80_06330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M1M80_06345	COG2267	carboxylic ester hydrolase activity
M1M80_06355	COG1744	ABC transporter substrate-binding protein PnrA-like
M1M80_06370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1M80_06375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1M80_06380	COG5504	Zn-dependent protease
M1M80_06385	COG0444	Belongs to the ABC transporter superfamily
M1M80_06390	COG4608	Belongs to the ABC transporter superfamily
M1M80_06400	COG0601	transmembrane transport
M1M80_06405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1M80_06415	COG0180	Tryptophanyl-tRNA synthetase
M1M80_06420	COG4166	transmembrane transport
M1M80_06425	COG0601	transmembrane transport
M1M80_06430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1M80_06435	COG0444	Belongs to the ABC transporter superfamily
M1M80_06440	COG4608	Belongs to the ABC transporter superfamily
M1M80_06445	COG2814	Major facilitator Superfamily
M1M80_06450	COG0456	acetyltransferase
M1M80_06455	COG1393	Belongs to the ArsC family
M1M80_06460	COG0861	Integral membrane protein TerC family
M1M80_06470	COG4862	establishment of competence for transformation
M1M80_06475	COG4469	Competence protein
M1M80_06480	COG1164	Oligoendopeptidase f
M1M80_06490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1M80_06495	COG2346	COG2346, Truncated hemoglobins
M1M80_06500	COG0741	lytic transglycosylase activity
M1M80_06505	COG4116	CYTH
M1M80_06515	COG2357	RelA SpoT domain protein
M1M80_06520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1M80_06525	COG0564	pseudouridine synthase activity
M1M80_06530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1M80_06535	COG0569	domain protein
M1M80_06535	COG0475	glutathione-regulated potassium exporter activity
M1M80_06540	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1M80_06545	COG0352	thiamine-phosphate diphosphorylase activity
M1M80_06550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1M80_06555	COG2104	thiamine diphosphate biosynthetic process
M1M80_06560	COG2022	thiamine diphosphate biosynthetic process
M1M80_06565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M1M80_06570	COG0351	phosphomethylpyrimidine kinase
M1M80_06575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M1M80_06630	COG0210	DNA helicase
M1M80_06640	COG2153	protein acetylation
M1M80_06645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M1M80_06650	COG2382	esterase
M1M80_06655	COG0626	cystathionine gamma-synthase activity
M1M80_06660	COG0626	cystathionine gamma-synthase activity
M1M80_06665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1M80_06670	COG5505	Protein of unknown function (DUF819)
M1M80_06680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1M80_06695	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_06705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1M80_06705	COG3711	transcriptional antiterminator
M1M80_06710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1M80_06710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1M80_06710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1M80_06715	COG1482	cell wall glycoprotein biosynthetic process
M1M80_06730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1M80_06740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1M80_06755	COG0109	protoheme IX farnesyltransferase activity
M1M80_06765	COG0726	polysaccharide deacetylase
M1M80_06780	COG5504	Zn-dependent protease
M1M80_06785	COG2205	protein histidine kinase activity
M1M80_06795	COG3383	formate dehydrogenase (NAD+) activity
M1M80_06800	COG2427	Protein of unknown function (DUF1641)
M1M80_06810	COG1051	belongs to the nudix hydrolase family
M1M80_06820	COG2124	cytochrome p450
M1M80_06825	COG1819	glycosyl
M1M80_06835	COG1587	Uroporphyrinogen-III synthase
M1M80_06840	COG0390	transport system, permease component
M1M80_06845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1M80_06850	COG0697	spore germination
M1M80_06855	COG4297	protein containing double-stranded beta helix domain
M1M80_06865	COG1252	NADH dehydrogenase
M1M80_06870	COG1904	glucuronate isomerase
M1M80_06875	COG2211	Major facilitator Superfamily
M1M80_06880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M1M80_06885	COG1063	alcohol dehydrogenase
M1M80_06890	COG1312	Catalyzes the dehydration of D-mannonate
M1M80_06895	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_06900	COG2271	Major facilitator Superfamily
M1M80_06905	COG1609	Transcriptional regulator
M1M80_06910	COG0246	Mannitol dehydrogenase
M1M80_06915	COG2721	sulfolactate sulfo-lyase activity
M1M80_06920	COG0730	response to heat
M1M80_06925	COG2318	DinB family
M1M80_06930	COG0457	Tetratricopeptide repeat
M1M80_06940	COG2350	Protein conserved in bacteria
M1M80_06945	COG1388	LysM domain
M1M80_06945	COG3409	Peptidoglycan-binding domain 1 protein
M1M80_06945	COG5632	N-Acetylmuramoyl-L-alanine amidase
M1M80_06955	COG4195	phage-related replication protein
M1M80_06960	COG3546	catalase activity
M1M80_06965	COG2856	Zn peptidase
M1M80_06970	COG1396	sequence-specific DNA binding
M1M80_06980	COG1522	sequence-specific DNA binding
M1M80_06985	COG1484	DNA-dependent DNA replication
M1M80_07005	COG1595	DNA-templated transcription, initiation
M1M80_07010	COG3728	DNA packaging
M1M80_07010	COG5484	DNA packaging
M1M80_07015	COG1783	phage Terminase large subunit
M1M80_07020	COG5518	Phage portal protein
M1M80_07025	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M1M80_07030	COG4653	Phage capsid family
M1M80_07080	COG3953	SLT domain
M1M80_07080	COG5412	phage tail tape measure protein
M1M80_07085	COG1652	LysM domain
M1M80_07090	COG4193	domain, Protein
M1M80_07100	COG3628	GPW Gp25 family protein
M1M80_07105	COG3299	homolog of phage Mu protein gp47
M1M80_07110	COG3778	Protein conserved in bacteria
M1M80_07155	COG3409	Peptidoglycan-binding domain 1 protein
M1M80_07155	COG5632	N-Acetylmuramoyl-L-alanine amidase
M1M80_07175	COG0306	phosphate transporter
M1M80_07180	COG1392	Phosphate transport regulator
M1M80_07185	COG0531	amino acid
M1M80_07190	COG0346	lactoylglutathione lyase activity
M1M80_07200	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M1M80_07205	COG0463	Glycosyl transferase, family 2
M1M80_07210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1M80_07215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1M80_07220	COG2362	D-Aminopeptidase
M1M80_07225	COG0601	transmembrane transport
M1M80_07230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1M80_07235	COG0444	Belongs to the ABC transporter superfamily
M1M80_07240	COG4166	transmembrane transport
M1M80_07245	COG1619	proteins homologs of microcin C7 resistance protein MccF
M1M80_07250	COG4948	Mandelate Racemase Muconate Lactonizing
M1M80_07255	COG0791	NLP P60 protein
M1M80_07260	COG4608	Belongs to the ABC transporter superfamily
M1M80_07265	COG2706	6-phosphogluconolactonase activity
M1M80_07270	COG1834	amidinotransferase
M1M80_07275	COG1607	acyl-coa hydrolase
M1M80_07280	COG1017	nitric oxide dioxygenase activity
M1M80_07280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1M80_07290	COG2323	membrane
M1M80_07295	COG2318	DinB family
M1M80_07300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1M80_07305	COG2076	Multidrug Resistance protein
M1M80_07310	COG2076	Multidrug Resistance protein
M1M80_07315	COG0788	formyltetrahydrofolate deformylase activity
M1M80_07320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M1M80_07325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M1M80_07330	COG1764	response to oxidative stress
M1M80_07335	COG1846	Transcriptional regulator
M1M80_07340	COG1764	response to oxidative stress
M1M80_07345	COG0457	Tetratricopeptide repeat
M1M80_07345	COG0463	Glycosyl transferase, family 2
M1M80_07350	COG0590	tRNA wobble adenosine to inosine editing
M1M80_07360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M1M80_07365	COG1404	Belongs to the peptidase S8 family
M1M80_07370	COG1366	Belongs to the anti-sigma-factor antagonist family
M1M80_07375	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M1M80_07380	COG1122	ATPase activity
M1M80_07385	COG4721	ABC-type cobalt transport system, permease component
M1M80_07395	COG0745	RESPONSE REGULATOR receiver
M1M80_07400	COG3850	Histidine kinase
M1M80_07400	COG5002	protein histidine kinase activity
M1M80_07405	COG3212	peptidase
M1M80_07410	COG3212	peptidase
M1M80_07420	COG2239	Acts as a magnesium transporter
M1M80_07425	COG0789	Transcriptional regulator
M1M80_07440	COG1846	Transcriptional regulator
M1M80_07450	COG0726	polysaccharide deacetylase
M1M80_07455	COG1408	metallophosphoesterase
M1M80_07465	COG0463	Glycosyl transferase, family 2
M1M80_07470	COG1793	dna ligase
M1M80_07470	COG3285	dna ligase
M1M80_07475	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M1M80_07480	COG3300	MHYT domain
M1M80_07480	COG5001	Diguanylate cyclase
M1M80_07485	COG0586	Pfam SNARE associated Golgi protein
M1M80_07490	COG0861	Integral membrane protein TerC family
M1M80_07495	COG1191	sigma factor activity
M1M80_07515	COG0501	Belongs to the peptidase M48B family
M1M80_07520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1M80_07535	COG3594	Acyltransferase
M1M80_07540	COG5002	protein histidine kinase activity
M1M80_07545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1M80_07555	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M1M80_07560	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
M1M80_07565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1M80_07570	COG0436	Aminotransferase
M1M80_07575	COG1850	ribulose-bisphosphate carboxylase activity
M1M80_07580	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
M1M80_07585	COG0235	Class ii aldolase
M1M80_07590	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M1M80_07595	COG3339	Conserved Protein
M1M80_07610	COG3852	Histidine kinase
M1M80_07615	COG1846	Transcriptional regulator
M1M80_07620	COG1360	Flagellar Motor Protein
M1M80_07625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M1M80_07630	COG0542	response to heat
M1M80_07635	COG3949	Membrane
M1M80_07640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1M80_07645	COG0720	synthase
M1M80_07650	COG0602	queuosine metabolic process
M1M80_07655	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M1M80_07660	COG1388	LysM domain
M1M80_07660	COG4641	Protein conserved in bacteria
M1M80_07665	COG1388	LysM domain
M1M80_07670	COG3858	chitin binding
M1M80_07680	COG4873	Protein conserved in bacteria
M1M80_07690	COG3773	Cell wall hydrolase
M1M80_07695	COG2244	polysaccharide biosynthetic process
M1M80_07700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1M80_07705	COG2217	Heavy metal translocating P-type atpase
M1M80_07715	COG0006	proline dipeptidase activity
M1M80_07720	COG1609	Transcriptional regulator
M1M80_07725	COG3711	transcriptional antiterminator
M1M80_07730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_07730	COG2190	(PTS) system
M1M80_07730	COG1263	PTS System
M1M80_07735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1M80_07740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1M80_07750	COG1533	DNA photolyase activity
M1M80_07755	COG0456	acetyltransferase
M1M80_07760	COG0840	transmembrane signaling receptor activity
M1M80_07765	COG2084	Dehydrogenase
M1M80_07775	COG2340	Cysteine-rich secretory protein family
M1M80_07780	COG0768	penicillin binding
M1M80_07785	COG4191	Histidine kinase
M1M80_07790	COG0436	Aminotransferase
M1M80_07800	COG0784	Response regulator, receiver
M1M80_07800	COG0835	chemotaxis
M1M80_07810	COG2814	Major facilitator Superfamily
M1M80_07815	COG1376	ErfK ybiS ycfS ynhG family protein
M1M80_07820	COG1408	metallophosphoesterase
M1M80_07825	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_07830	COG2200	EAL domain
M1M80_07840	COG4703	Protein of unknown function (DUF1797)
M1M80_07845	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M1M80_07855	COG0517	IMP dehydrogenase activity
M1M80_07860	COG0583	DNA-binding transcription factor activity
M1M80_07865	COG0716	FMN binding
M1M80_07875	COG0716	FMN binding
M1M80_07880	COG2171	N-acyltransferase activity
M1M80_07885	COG1473	amidohydrolase
M1M80_07895	COG0668	transmembrane transport
M1M80_07900	COG0450	alkyl hydroperoxide reductase
M1M80_07905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1M80_07920	COG0746	molybdenum cofactor guanylyltransferase activity
M1M80_07925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M1M80_07930	COG0303	'Molybdopterin
M1M80_07935	COG1763	Mo-molybdopterin cofactor biosynthetic process
M1M80_07940	COG0314	molybdopterin synthase activity
M1M80_07945	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M1M80_07950	COG1132	(ABC) transporter
M1M80_07955	COG1132	(ABC) transporter
M1M80_07965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1M80_07970	COG1136	(ABC) transporter
M1M80_07975	COG0577	efflux transmembrane transporter activity
M1M80_07980	COG1349	DNA-binding transcription factor activity
M1M80_07985	COG1105	Belongs to the carbohydrate kinase PfkB family
M1M80_07990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1M80_07990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1M80_07990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1M80_07995	COG0681	Belongs to the peptidase S26 family
M1M80_08005	COG0488	(ABC) transporter
M1M80_08010	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M1M80_08015	COG2309	aminopeptidase activity
M1M80_08025	COG1077	Cell shape determining protein MreB Mrl
M1M80_08030	COG2002	toxin-antitoxin pair type II binding
M1M80_08035	COG3852	Histidine kinase
M1M80_08040	COG2105	PFAM AIG2 family protein
M1M80_08040	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M1M80_08045	COG0569	domain protein
M1M80_08050	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1M80_08055	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M1M80_08060	COG5503	Protein of unknown function (DUF1447)
M1M80_08065	COG0561	phosphatase activity
M1M80_08070	COG0242	peptide deformylase activity
M1M80_08080	COG0497	DNA recombination
M1M80_08085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1M80_08090	COG0022	dehydrogenase e1 component
M1M80_08095	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1M80_08100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1M80_08105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1M80_08120	COG1982	Orn Lys Arg decarboxylase major
M1M80_08125	COG4476	Belongs to the UPF0223 family
M1M80_08130	COG4493	Belongs to the UPF0637 family
M1M80_08140	COG0483	inositol monophosphate 1-phosphatase activity
M1M80_08155	COG0657	acetylesterase activity
M1M80_08160	COG1959	2 iron, 2 sulfur cluster binding
M1M80_08180	COG1595	DNA-templated transcription, initiation
M1M80_08200	COG1217	gtp-binding protein TYPA
M1M80_08210	COG4896	Protein conserved in bacteria
M1M80_08220	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M1M80_08225	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M1M80_08230	COG2066	Belongs to the glutaminase family
M1M80_08235	COG4838	Belongs to the UPF0358 family
M1M80_08240	COG0772	Belongs to the SEDS family
M1M80_08245	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M1M80_08250	COG1612	heme a metabolic process
M1M80_08255	COG0109	protoheme IX farnesyltransferase activity
M1M80_08260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1M80_08260	COG2010	Cytochrome c
M1M80_08265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1M80_08270	COG1845	cytochrome c oxidase, subunit III
M1M80_08275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1M80_08280	COG3336	cytochrome c oxidase
M1M80_08290	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M1M80_08295	COG2340	Cysteine-rich secretory protein family
M1M80_08310	COG3679	Belongs to the UPF0342 family
M1M80_08315	COG4471	UPF0298 protein
M1M80_08320	COG0742	ribosomal rna small subunit methyltransferase
M1M80_08325	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M1M80_08330	COG3314	Sporulation integral membrane protein YlbJ
M1M80_08335	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1M80_08340	COG3480	Lon protease (S16) C-terminal proteolytic domain
M1M80_08345	COG1323	Belongs to the UPF0348 family
M1M80_08355	COG1399	metal-binding, possibly nucleic acid-binding protein
M1M80_08370	COG0454	-acetyltransferase
M1M80_08375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M1M80_08380	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
M1M80_08385	COG2001	Belongs to the MraZ family
M1M80_08390	COG0275	rRNA processing
M1M80_08395	COG4839	cell division protein FtsL
M1M80_08400	COG0768	penicillin binding
M1M80_08405	COG0768	penicillin binding
M1M80_08410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1M80_08415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M1M80_08420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M1M80_08425	COG0772	Belongs to the SEDS family
M1M80_08430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M1M80_08435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M1M80_08440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1M80_08445	COG3879	Bacterial protein of unknown function (DUF881)
M1M80_08450	COG3879	Bacterial protein of unknown function (DUF881)
M1M80_08455	COG3856	small basic protein
M1M80_08460	COG0849	cell division
M1M80_08465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1M80_08470	COG1404	Belongs to the peptidase S8 family
M1M80_08470	COG4412	M6 family metalloprotease domain protein
M1M80_08480	COG1191	sigma factor activity
M1M80_08485	COG1191	sigma factor activity
M1M80_08490	COG1119	ATPase activity
M1M80_08495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1M80_08500	COG1873	PFAM PRC-barrel domain
M1M80_08505	COG1496	oxidoreductase activity
M1M80_08510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M1M80_08515	COG1799	cell septum assembly
M1M80_08520	COG0762	integral membrane protein
M1M80_08525	COG2302	S4 RNA-binding domain
M1M80_08530	COG3599	regulation of cell shape
M1M80_08535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1M80_08540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1M80_08545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M1M80_08550	COG0564	pseudouridine synthase activity
M1M80_08555	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M1M80_08560	COG2233	PERMEase
M1M80_08565	COG0540	Belongs to the ATCase OTCase family
M1M80_08570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M1M80_08575	COG0505	Belongs to the CarA family
M1M80_08580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M1M80_08585	COG0543	2 iron, 2 sulfur cluster binding
M1M80_08590	COG0167	dihydroorotate dehydrogenase activity
M1M80_08595	COG0284	orotidine-5'-phosphate decarboxylase activity
M1M80_08600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M1M80_08605	COG0175	sulfate reduction
M1M80_08610	COG0306	phosphate transporter
M1M80_08615	COG2046	Belongs to the sulfate adenylyltransferase family
M1M80_08620	COG0529	Catalyzes the synthesis of activated sulfate
M1M80_08625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1M80_08630	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M1M80_08635	COG1648	precorrin-2 dehydrogenase activity
M1M80_08640	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M1M80_08645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1M80_08650	COG1561	YicC-like family, N-terminal region
M1M80_08660	COG0194	GDP metabolic process
M1M80_08665	COG1758	RNA polymerase activity
M1M80_08670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1M80_08675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1M80_08680	COG0242	peptide deformylase activity
M1M80_08685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M1M80_08690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M1M80_08690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M1M80_08695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M1M80_08700	COG0631	protein serine/threonine phosphatase activity
M1M80_08705	COG0515	serine threonine protein kinase
M1M80_08705	COG2815	serine threonine protein kinase
M1M80_08710	COG1162	GTPase activity
M1M80_08715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1M80_08720	COG1564	THIamine pyrophosphokinase
M1M80_08730	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M1M80_08735	COG1302	Protein conserved in bacteria
M1M80_08740	COG1461	Dihydroxyacetone kinase
M1M80_08745	COG1760	l-serine dehydratase
M1M80_08750	COG1760	l-serine dehydratase
M1M80_08755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1M80_08760	COG1349	DNA-binding transcription factor activity
M1M80_08760	COG2050	protein possibly involved in aromatic compounds catabolism
M1M80_08765	COG0416	fatty acid biosynthetic process
M1M80_08770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1M80_08775	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_08785	COG0571	ribonuclease III activity
M1M80_08790	COG1196	nuclear chromosome segregation
M1M80_08795	COG0552	protein localization to endoplasmic reticulum
M1M80_08805	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M1M80_08810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1M80_08815	COG0228	four-way junction DNA binding
M1M80_08820	COG1837	Belongs to the UPF0109 family
M1M80_08830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1M80_08835	COG0336	Belongs to the RNA methyltransferase TrmD family
M1M80_08840	COG0335	large ribosomal subunit rRNA binding
M1M80_08845	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M1M80_08850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1M80_08860	COG2257	FlhB HrpN YscU SpaS Family
M1M80_08865	COG0045	succinate-CoA ligase (ADP-forming) activity
M1M80_08870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M1M80_08875	COG0758	DNA mediated transformation
M1M80_08880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1M80_08885	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M1M80_08890	COG4974	Belongs to the 'phage' integrase family
M1M80_08895	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M1M80_08900	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M1M80_08905	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1M80_08910	COG1815	bacterial-type flagellum-dependent cell motility
M1M80_08915	COG1558	bacterial-type flagellum-dependent cell motility
M1M80_08920	COG1677	Flagellar hook-basal body complex protein FliE
M1M80_08925	COG1766	The M ring may be actively involved in energy transduction
M1M80_08930	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M1M80_08935	COG1317	bacterial-type flagellum organization
M1M80_08940	COG1157	protein secretion by the type III secretion system
M1M80_08945	COG2882	bacterial-type flagellum organization
M1M80_08950	COG3334	PFAM MgtE intracellular
M1M80_08955	COG3144	bacterial-type flagellum assembly
M1M80_08960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M1M80_08965	COG4786	Flagellar basal body rod
M1M80_08970	COG1582	Flagellar protein (FlbD)
M1M80_08975	COG1580	Controls the rotational direction of flagella during chemotaxis
M1M80_08980	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M1M80_08985	COG1776	CheC inhibitor of MCP methylation
M1M80_08985	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M1M80_08990	COG2201	protein-glutamate methylesterase activity
M1M80_08995	COG3190	flagellar
M1M80_09000	COG1338	Plays a role in the flagellum-specific transport system
M1M80_09005	COG1987	bacterial-type flagellum assembly
M1M80_09015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M1M80_09020	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M1M80_09025	COG1419	protein localization to endoplasmic reticulum
M1M80_09030	COG0455	bacterial-type flagellum organization
M1M80_09035	COG2201	protein-glutamate methylesterase activity
M1M80_09040	COG2198	Histidine kinase
M1M80_09040	COG0643	Histidine kinase
M1M80_09045	COG0835	chemotaxis
M1M80_09050	COG1776	CheC inhibitor of MCP methylation
M1M80_09055	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
M1M80_09060	COG1191	sigma factor activity
M1M80_09070	COG0052	Belongs to the universal ribosomal protein uS2 family
M1M80_09075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M1M80_09080	COG0528	UMP kinase activity
M1M80_09085	COG0233	cytoplasmic translational termination
M1M80_09090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1M80_09095	COG4589	Belongs to the CDS family
M1M80_09100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M1M80_09105	COG0750	zinc metalloprotease
M1M80_09110	COG0442	prolyl-tRNA aminoacylation
M1M80_09115	COG2176	DNA-directed DNA polymerase activity
M1M80_09120	COG0779	Required for maturation of 30S ribosomal subunits
M1M80_09125	COG0195	Participates in both transcription termination and antitermination
M1M80_09130	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M1M80_09135	COG1358	cellular component organization or biogenesis
M1M80_09140	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M1M80_09145	COG1550	Protein conserved in bacteria
M1M80_09150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M1M80_09155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1M80_09160	COG0196	riboflavin kinase activity
M1M80_09170	COG1185	polyribonucleotide nucleotidyltransferase activity
M1M80_09175	COG0726	polysaccharide deacetylase
M1M80_09180	COG0612	Peptidase, M16
M1M80_09185	COG1873	PFAM PRC-barrel domain
M1M80_09190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M1M80_09195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1M80_09200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M1M80_09205	COG0527	aspartate kinase activity
M1M80_09210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1M80_09215	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M1M80_09220	COG0740	serine-type endopeptidase activity
M1M80_09230	COG1674	ftsk spoiiie
M1M80_09230	COG4980	gas vesicle protein
M1M80_09235	COG2188	Transcriptional regulator
M1M80_09240	COG2814	Major facilitator Superfamily
M1M80_09245	COG0612	Peptidase, M16
M1M80_09250	COG0612	Peptidase, M16
M1M80_09255	COG0300	oxidoreductase activity
M1M80_09270	COG1426	Protein conserved in bacteria
M1M80_09275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1M80_09280	COG1058	Belongs to the CinA family
M1M80_09280	COG1546	Belongs to the CinA family
M1M80_09285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M1M80_09290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1M80_09295	COG1418	mRNA catabolic process
M1M80_09300	COG1692	metallophosphoesterase
M1M80_09305	COG2359	stage V sporulation protein S
M1M80_09310	COG1063	alcohol dehydrogenase
M1M80_09315	COG0156	8-amino-7-oxononanoate synthase activity
M1M80_09320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1M80_09325	COG4550	Control of competence regulator ComK, YlbF/YmcA
M1M80_09335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M1M80_09340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1M80_09345	COG4974	Belongs to the 'phage' integrase family
M1M80_09385	COG3226	Transcriptional regulator
M1M80_09395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1M80_09400	COG1404	Belongs to the peptidase S8 family
M1M80_09410	COG4195	phage-related replication protein
M1M80_09415	COG1764	response to oxidative stress
M1M80_09440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M1M80_09445	COG1923	regulation of RNA biosynthetic process
M1M80_09460	COG1780	Probably involved in ribonucleotide reductase function
M1M80_09465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1M80_09470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1M80_09475	COG4112	unkown
M1M80_09480	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1M80_09485	COG0464	growth
M1M80_09490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1M80_09495	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M1M80_09500	COG0789	Transcriptional regulator
M1M80_09505	COG0174	glutamine synthetase
M1M80_09540	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1M80_09545	COG1733	regulation of RNA biosynthetic process
M1M80_09585	COG0135	phosphoribosylanthranilate isomerase activity
M1M80_09620	COG2211	Major facilitator Superfamily
M1M80_09625	COG3507	Belongs to the glycosyl hydrolase 43 family
M1M80_09640	COG1070	Carbohydrate kinase
M1M80_09650	COG1525	nuclease
M1M80_09655	COG2814	Major facilitator Superfamily
M1M80_09665	COG0756	dUTP diphosphatase activity
M1M80_09715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M1M80_09730	COG3832	glyoxalase III activity
M1M80_09740	COG2059	Chromate
M1M80_09745	COG0697	spore germination
M1M80_09750	COG0531	amino acid
M1M80_09780	COG4195	phage-related replication protein
M1M80_09790	COG0346	lactoylglutathione lyase activity
M1M80_09800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1M80_09805	COG1388	LysM domain
M1M80_09810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1M80_09815	COG4224	UPF0291 protein
M1M80_09820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1M80_09830	COG3763	UPF0154 protein
M1M80_09840	COG0785	Cytochrome C biogenesis protein
M1M80_09845	COG2201	protein-glutamate methylesterase activity
M1M80_09850	COG4846	Membrane protein involved in cytochrome C biogenesis
M1M80_09860	COG0071	Belongs to the small heat shock protein (HSP20) family
M1M80_09875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1M80_09880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1M80_09900	COG0824	Thioesterase
M1M80_09910	COG4841	protein insertion into membrane
M1M80_09915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M1M80_09920	COG1832	CoA-binding protein
M1M80_09925	COG0187	DNA topoisomerase II activity
M1M80_09930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M1M80_09940	COG1115	amino acid carrier protein
M1M80_09955	COG5520	Belongs to the glycosyl hydrolase 30 family
M1M80_09990	COG2246	polysaccharide biosynthetic process
M1M80_09995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1M80_10000	COG0586	Pfam SNARE associated Golgi protein
M1M80_10005	COG2404	hydrolase activity, acting on ester bonds
M1M80_10010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1M80_10015	COG1024	Enoyl-CoA hydratase
M1M80_10020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1M80_10025	COG0511	ligase activity, forming carbon-carbon bonds
M1M80_10030	COG0439	Biotin carboxylase
M1M80_10035	COG0318	PFAM AMP-dependent synthetase and ligase
M1M80_10040	COG1960	acyl-CoA dehydrogenase activity
M1M80_10060	COG1649	PFAM Uncharacterised BCR, COG1649
M1M80_10070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_10070	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1M80_10075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_10080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_10085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_10090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_10095	COG2027	D-alanyl-D-alanine carboxypeptidase
M1M80_10100	COG2017	converts alpha-aldose to the beta-anomer
M1M80_10105	COG0534	Mate efflux family protein
M1M80_10120	COG0582	viral genome integration into host DNA
M1M80_10125	COG0166	Belongs to the GPI family
M1M80_10130	COG0405	Gamma-glutamyltransferase
M1M80_10135	COG0583	DNA-binding transcription factor activity
M1M80_10140	COG0604	alcohol dehydrogenase
M1M80_10145	COG0493	'glutamate synthase
M1M80_10150	COG0067	glutamate synthase
M1M80_10150	COG0070	glutamate synthase
M1M80_10150	COG0069	glutamate synthase activity
M1M80_10155	COG0583	DNA-binding transcription factor activity
M1M80_10160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M1M80_10175	COG0300	oxidoreductase activity
M1M80_10180	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M1M80_10190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1M80_10195	COG2814	Major facilitator Superfamily
M1M80_10200	COG1070	Carbohydrate kinase
M1M80_10205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1M80_10210	COG0243	molybdopterin cofactor binding
M1M80_10225	COG1082	Xylose isomerase domain protein TIM barrel
M1M80_10240	COG5278	phosphoserine phosphatase activity
M1M80_10240	COG0840	transmembrane signaling receptor activity
M1M80_10245	COG2368	4-hydroxyphenylacetate
M1M80_10250	COG4305	rare lipoprotein A
M1M80_10255	COG3619	membrane
M1M80_10280	COG2135	peptidase activity
M1M80_10290	COG2140	Oxalate decarboxylase
M1M80_10300	COG0457	Tetratricopeptide repeat
M1M80_10325	COG2720	vancomycin resistance protein
M1M80_10340	COG3739	integral membrane protein
M1M80_10345	COG0583	DNA-binding transcription factor activity
M1M80_10350	COG0697	spore germination
M1M80_10355	COG1388	LysM domain
M1M80_10365	COG0693	protein deglycase activity
M1M80_10370	COG2367	Beta-lactamase
M1M80_10380	COG3397	chitin binding
M1M80_10385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1M80_10390	COG0574	Belongs to the PEP-utilizing enzyme family
M1M80_10390	COG3848	Pyruvate phosphate dikinase
M1M80_10410	COG4282	regulation of fungal-type cell wall biogenesis
M1M80_10415	COG1231	oxidoreductase activity
M1M80_10425	COG0726	polysaccharide deacetylase
M1M80_10495	COG3655	Transcriptional regulator
M1M80_10535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M1M80_10540	COG0463	Glycosyl transferase, family 2
M1M80_10545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1M80_10550	COG3271	cysteine-type peptidase activity
M1M80_10550	COG2274	protein secretion by the type I secretion system
M1M80_10565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1M80_10635	COG1404	Belongs to the peptidase S8 family
M1M80_10645	COG1404	Belongs to the peptidase S8 family
M1M80_10655	COG0577	efflux transmembrane transporter activity
M1M80_10655	COG1136	(ABC) transporter
M1M80_10670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1M80_10675	COG0662	Cupin 2, conserved barrel domain protein
M1M80_10675	COG2207	Transcriptional regulator
M1M80_10680	COG0456	acetyltransferase
M1M80_10685	COG1309	transcriptional regulator
M1M80_10690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1M80_10695	COG3708	Transcriptional regulator
M1M80_10700	COG2378	regulation of single-species biofilm formation
M1M80_10710	COG0640	Transcriptional regulator
M1M80_10715	COG0741	lytic transglycosylase activity
M1M80_10720	COG2322	membrane
M1M80_10735	COG1619	proteins homologs of microcin C7 resistance protein MccF
M1M80_10740	COG3239	Fatty acid desaturase
M1M80_10745	COG4585	Histidine kinase
M1M80_10750	COG2197	response regulator
M1M80_10755	COG1388	LysM domain
M1M80_10755	COG3584	3D domain protein
M1M80_10760	COG0514	ATP-dependent DNA helicase (RecQ)
M1M80_10770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1M80_10775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1M80_10790	COG1012	belongs to the aldehyde dehydrogenase family
M1M80_10795	COG1657	PFAM Prenyltransferase squalene oxidase
M1M80_10800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1M80_10805	COG0733	neurotransmitter:sodium symporter activity
M1M80_10810	COG0385	Bile acid
M1M80_10815	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1M80_10820	COG0567	Dehydrogenase, E1 component
M1M80_10825	COG4548	von Willebrand factor, type A
M1M80_10830	COG0714	Associated with various cellular activities
M1M80_10835	COG2032	superoxide dismutase activity
M1M80_10840	COG0791	NLP P60 protein
M1M80_10840	COG1388	LysM domain
M1M80_10845	COG1819	glycosyl
M1M80_10850	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M1M80_10855	COG0534	Mate efflux family protein
M1M80_10860	COG1366	Belongs to the anti-sigma-factor antagonist family
M1M80_10865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M1M80_10870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M1M80_10880	COG2962	Rard protein
M1M80_10895	COG2610	gluconate transmembrane transporter activity
M1M80_10900	COG1942	4-Oxalocrotonate Tautomerase
M1M80_10910	COG1733	regulation of RNA biosynthetic process
M1M80_10915	COG0778	Nitroreductase
M1M80_10920	COG0400	carboxylic ester hydrolase activity
M1M80_10925	COG0346	lactoylglutathione lyase activity
M1M80_10935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1M80_10940	COG0793	Belongs to the peptidase S41A family
M1M80_10940	COG3409	Peptidoglycan-binding domain 1 protein
M1M80_10945	COG2226	methyltransferase
M1M80_10955	COG1876	peptidase activity
M1M80_10960	COG0813	purine-nucleoside phosphorylase activity
M1M80_10975	COG0671	phosphoesterase, PA-phosphatase related
M1M80_10995	COG4479	Belongs to the UPF0346 family
M1M80_11005	COG1509	lysine 2,3-aminomutase activity
M1M80_11010	COG0456	acetyltransferase
M1M80_11015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1M80_11020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1M80_11025	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1M80_11030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M1M80_11040	COG0456	acetyltransferase
M1M80_11045	COG0463	Glycosyl transferase, family 2
M1M80_11060	COG4641	Protein conserved in bacteria
M1M80_11065	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
M1M80_11070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1M80_11075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1M80_11080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1M80_11085	COG1846	Transcriptional regulator
M1M80_11090	COG0534	Mate efflux family protein
M1M80_11100	COG4698	Protein conserved in bacteria
M1M80_11105	COG2755	lipolytic protein G-D-S-L family
M1M80_11110	COG1999	signal sequence binding
M1M80_11120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1M80_11125	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M1M80_11130	COG1272	protein, Hemolysin III
M1M80_11135	COG0204	Acyl-transferase
M1M80_11140	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1M80_11150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1M80_11160	COG2136	Putative SAM-dependent methyltransferase
M1M80_11160	COG2521	methyltransferase
M1M80_11170	COG0129	dihydroxy-acid dehydratase activity
M1M80_11175	COG1413	lyase activity
M1M80_11180	COG1418	mRNA catabolic process
M1M80_11185	COG0386	Belongs to the glutathione peroxidase family
M1M80_11190	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M1M80_11195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M1M80_11205	COG1278	Cold shock
M1M80_11225	COG0328	RNA-DNA hybrid ribonuclease activity
M1M80_11230	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M1M80_11235	COG0328	RNA-DNA hybrid ribonuclease activity
M1M80_11245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1M80_11260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M1M80_11270	COG1755	Isoprenylcysteine carboxyl methyltransferase
M1M80_11275	COG3424	synthase
M1M80_11280	COG2233	PERMEase
M1M80_11285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M1M80_11290	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M1M80_11300	COG0800	Aldolase
M1M80_11305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1M80_11310	COG1609	Transcriptional regulator
M1M80_11315	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M1M80_11320	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_11325	COG1199	ATP-dependent helicase activity
M1M80_11340	COG0116	Belongs to the methyltransferase superfamily
M1M80_11355	COG4474	Belongs to the UPF0398 family
M1M80_11370	COG3359	exonuclease
M1M80_11375	COG1111	helicase
M1M80_11375	COG1205	dead DEAH box helicase
M1M80_11380	COG2190	(PTS) system
M1M80_11385	COG0071	Belongs to the small heat shock protein (HSP20) family
M1M80_11420	COG3331	DNA recombination
M1M80_11425	COG4499	WXG100 protein secretion system (Wss), protein YukC
M1M80_11425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1M80_11435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1M80_11440	COG3935	DnaD domain protein
M1M80_11445	COG0017	Asparaginyl-tRNA synthetase
M1M80_11450	COG0436	Aminotransferase
M1M80_11455	COG5353	protein conserved in bacteria
M1M80_11465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1M80_11465	COG1199	ATP-dependent helicase activity
M1M80_11470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M1M80_11475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M1M80_11480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M1M80_11485	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M1M80_11485	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M1M80_11490	COG0617	tRNA 3'-terminal CCA addition
M1M80_11495	COG0438	transferase activity, transferring glycosyl groups
M1M80_11500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M1M80_11505	COG1803	Methylglyoxal synthase
M1M80_11510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M1M80_11515	COG1694	Mazg nucleotide pyrophosphohydrolase
M1M80_11520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1M80_11530	COG4347	Protein of unknown function (DUF1405)
M1M80_11535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M1M80_11535	COG2010	Cytochrome c
M1M80_11540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M1M80_11545	COG0723	plastoquinol--plastocyanin reductase activity
M1M80_11555	COG5582	Belongs to the UPF0302 family
M1M80_11560	COG0457	Tetratricopeptide repeat
M1M80_11565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1M80_11570	COG0287	Prephenate dehydrogenase
M1M80_11575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M1M80_11580	COG0159	tryptophan synthase activity
M1M80_11585	COG0133	tryptophan synthase activity
M1M80_11590	COG0135	phosphoribosylanthranilate isomerase activity
M1M80_11600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1M80_11605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1M80_11610	COG4401	Chorismate mutase type I
M1M80_11615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M1M80_11620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M1M80_11625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M1M80_11630	COG0105	UTP biosynthetic process
M1M80_11635	COG0142	geranyltranstransferase activity
M1M80_11640	COG2226	methyltransferase
M1M80_11645	COG0142	geranyltranstransferase activity
M1M80_11655	COG0302	gtp cyclohydrolase
M1M80_11660	COG0776	regulation of translation
M1M80_11665	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M1M80_11680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M1M80_11685	COG1160	GTP binding
M1M80_11710	COG1304	FMN binding
M1M80_11715	COG0539	negative regulation of cytoplasmic translation
M1M80_11720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M1M80_11730	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M1M80_11735	COG2959	enzyme of heme biosynthesis
M1M80_11740	COG3409	Peptidoglycan-binding domain 1 protein
M1M80_11740	COG3773	Cell wall hydrolase
M1M80_11745	COG2339	peptidase activity
M1M80_11750	COG0492	ferredoxin-NADP+ reductase activity
M1M80_11755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1M80_11760	COG4862	establishment of competence for transformation
M1M80_11765	COG1408	metallophosphoesterase
M1M80_11775	COG1388	LysM domain
M1M80_11780	COG1266	CAAX protease self-immunity
M1M80_11785	COG0514	ATP-dependent DNA helicase (RecQ)
M1M80_11790	COG4955	Helix-turn-helix domain
M1M80_11795	COG1141	Ferredoxin
M1M80_11800	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M1M80_11805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1M80_11810	COG0710	3-dehydroquinate dehydratase activity
M1M80_11820	COG1595	DNA-templated transcription, initiation
M1M80_11825	COG5002	protein histidine kinase activity
M1M80_11830	COG0745	RESPONSE REGULATOR receiver
M1M80_11835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M1M80_11840	COG1333	cytochrome c biogenesis protein
M1M80_11845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1M80_11850	COG1187	pseudouridine synthase activity
M1M80_11855	COG0700	Nucleoside recognition
M1M80_11860	COG2715	membrane protein required for spore maturation
M1M80_11865	COG1686	Belongs to the peptidase S11 family
M1M80_11875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1M80_11880	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1M80_11885	COG1547	Domain of unknown function (DUF309)
M1M80_11890	COG0456	acetyltransferase
M1M80_11895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M1M80_11900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1M80_11900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1M80_11905	COG0307	riboflavin synthase, alpha
M1M80_11910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1M80_11910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1M80_11925	COG0681	Belongs to the peptidase S26 family
M1M80_11930	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
M1M80_11945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1M80_11950	COG4086	secreted protein
M1M80_11955	COG0019	diaminopimelate decarboxylase activity
M1M80_11960	COG0697	spore germination
M1M80_11975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1M80_11995	COG1191	sigma factor activity
M1M80_12005	COG1366	Belongs to the anti-sigma-factor antagonist family
M1M80_12010	COG1686	Belongs to the peptidase S11 family
M1M80_12015	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M1M80_12020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M1M80_12025	COG4974	Belongs to the 'phage' integrase family
M1M80_12035	COG0735	belongs to the Fur family
M1M80_12040	COG1300	Membrane
M1M80_12050	COG0281	malic enzyme
M1M80_12055	COG1757	Na H antiporter
M1M80_12060	COG1027	Aspartate ammonia-lyase
M1M80_12065	COG0252	asparaginase activity
M1M80_12070	COG1396	sequence-specific DNA binding
M1M80_12075	COG1379	DNA repair
M1M80_12080	COG0494	nUDIX hydrolase
M1M80_12090	COG0667	Aldo Keto reductase
M1M80_12100	COG1073	alpha beta
M1M80_12110	COG4918	Iron-sulphur cluster biosynthesis
M1M80_12115	COG0456	acetyltransferase
M1M80_12115	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1M80_12120	COG2329	Antibiotic biosynthesis monooxygenase
M1M80_12125	COG0456	acetyltransferase
M1M80_12135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1M80_12165	COG1072	(Pantothenic acid kinase))
M1M80_12170	COG3048	D-serine ammonia-lyase activity
M1M80_12175	COG0300	oxidoreductase activity
M1M80_12180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1M80_12185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1M80_12190	COG4187	Peptidase family M20/M25/M40
M1M80_12195	COG1902	pentaerythritol trinitrate reductase activity
M1M80_12200	COG0596	Alpha beta hydrolase
M1M80_12210	COG1234	tRNA 3'-trailer cleavage
M1M80_12215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M1M80_12220	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M1M80_12225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1M80_12235	COG0706	membrane insertase activity
M1M80_12240	COG3361	conserved protein (COG2071)
M1M80_12245	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1M80_12250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1M80_12255	COG0346	lactoylglutathione lyase activity
M1M80_12265	COG1376	ErfK ybiS ycfS ynhG family protein
M1M80_12270	COG4129	membrane
M1M80_12275	COG1126	abc transporter atp-binding protein
M1M80_12280	COG0765	amino acid transport
M1M80_12285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1M80_12295	COG1597	lipid kinase activity
M1M80_12300	COG2814	Major facilitator Superfamily
M1M80_12305	COG0789	Transcriptional regulator
M1M80_12305	COG4978	Transcriptional regulator
M1M80_12310	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1M80_12315	COG0022	dehydrogenase e1 component
M1M80_12320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1M80_12325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1M80_12330	COG3426	butyrate kinase activity
M1M80_12335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1M80_12340	COG0280	phosphate acetyltransferase
M1M80_12345	COG3829	transcription factor binding
M1M80_12345	COG3290	protein histidine kinase activity
M1M80_12355	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M1M80_12360	COG2079	MmgE PrpD family protein
M1M80_12365	COG0372	Belongs to the citrate synthase family
M1M80_12370	COG1960	acyl-CoA dehydrogenase activity
M1M80_12375	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1M80_12380	COG0183	Belongs to the thiolase family
M1M80_12385	COG0584	glycerophosphoryl diester phosphodiesterase
M1M80_12390	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1M80_12405	COG1902	pentaerythritol trinitrate reductase activity
M1M80_12415	COG0745	RESPONSE REGULATOR receiver
M1M80_12420	COG0750	zinc metalloprotease
M1M80_12425	COG0497	DNA recombination
M1M80_12430	COG1438	arginine binding
M1M80_12435	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M1M80_12440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M1M80_12445	COG0142	geranyltranstransferase activity
M1M80_12450	COG1722	exodeoxyribonuclease VII activity
M1M80_12455	COG1570	exodeoxyribonuclease VII activity
M1M80_12460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M1M80_12465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M1M80_12470	COG1302	Protein conserved in bacteria
M1M80_12475	COG0439	Biotin carboxylase
M1M80_12480	COG0511	ligase activity, forming carbon-carbon bonds
M1M80_12520	COG3854	ATPases associated with a variety of cellular activities
M1M80_12530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M1M80_12535	COG0006	proline dipeptidase activity
M1M80_12540	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M1M80_12550	COG3872	metal-dependent enzyme
M1M80_12560	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1M80_12565	COG1321	iron dependent repressor
M1M80_12570	COG0095	Lipoate-protein ligase
M1M80_12575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1M80_12580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M1M80_12585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M1M80_12590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M1M80_12595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M1M80_12610	COG1396	sequence-specific DNA binding
M1M80_12620	COG0681	Belongs to the peptidase S26 family
M1M80_12645	COG4940	Competence protein ComGF
M1M80_12655	COG4970	Tfp pilus assembly protein FimT
M1M80_12660	COG4537	Required for transformation and DNA binding
M1M80_12665	COG1459	type II secretion system
M1M80_12670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1M80_12680	COG0517	IMP dehydrogenase activity
M1M80_12685	COG0598	Magnesium transport protein CorA
M1M80_12690	COG1253	flavin adenine dinucleotide binding
M1M80_12695	COG1366	Belongs to the anti-sigma-factor antagonist family
M1M80_12705	COG1393	Belongs to the ArsC family
M1M80_12715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1M80_12725	COG0011	TIGRFAM Protein of
M1M80_12735	COG2866	Carboxypeptidase
M1M80_12740	COG1368	sulfuric ester hydrolase activity
M1M80_12745	COG1940	carbohydrate kinase activity
M1M80_12755	COG0457	Tetratricopeptide repeat
M1M80_12755	COG0705	Rhomboid family
M1M80_12765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1M80_12775	COG0438	transferase activity, transferring glycosyl groups
M1M80_12790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1M80_12795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1M80_12800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1M80_12805	COG0581	inorganic phosphate transmembrane transporter activity
M1M80_12810	COG0573	inorganic phosphate transmembrane transporter activity
M1M80_12815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1M80_12820	COG0768	penicillin binding
M1M80_12825	COG0477	Major facilitator Superfamily
M1M80_12830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1M80_12835	COG2839	Protein conserved in bacteria
M1M80_12840	COG5521	maltodextrose utilization protein MalA
M1M80_12845	COG1388	LysM domain
M1M80_12850	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M1M80_12855	COG4709	membrane
M1M80_12860	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M1M80_12865	COG0735	belongs to the Fur family
M1M80_12870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1M80_12880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M1M80_12885	COG0513	Belongs to the DEAD box helicase family
M1M80_12895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M1M80_12900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1M80_12905	COG2384	SAM-dependent methyltransferase
M1M80_12910	COG2010	Cytochrome c
M1M80_12915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M1M80_12920	COG0358	DNA primase activity
M1M80_12925	COG1671	Belongs to the UPF0178 family
M1M80_12930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M1M80_12935	COG0517	IMP dehydrogenase activity
M1M80_12940	COG0751	glycine-tRNA ligase activity
M1M80_12945	COG0752	glycyl-tRNA synthetase alpha subunit
M1M80_12950	COG1381	Involved in DNA repair and RecF pathway recombination
M1M80_12960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1M80_12965	COG0295	cytidine deaminase activity
M1M80_12970	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M1M80_12975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M1M80_12980	COG1480	7TM receptor with intracellular HD hydrolase
M1M80_12985	COG1702	phosphate starvation-inducible protein PhoH
M1M80_12990	COG0561	phosphatase activity
M1M80_13005	COG4864	UPF0365 protein
M1M80_13010	COG1030	water channel activity
M1M80_13015	COG1610	YqeY-like protein
M1M80_13025	COG1283	sodium-dependent phosphate transmembrane transporter activity
M1M80_13030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1M80_13035	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1M80_13040	COG2264	protein methyltransferase activity
M1M80_13055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M1M80_13060	COG1420	regulation of RNA biosynthetic process
M1M80_13065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1M80_13070	COG0481	GTPase activity
M1M80_13080	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1M80_13085	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M1M80_13090	COG0268	Binds directly to 16S ribosomal RNA
M1M80_13095	COG1466	dna polymerase III delta subunit
M1M80_13110	COG0658	competence protein
M1M80_13110	COG2333	competence protein COMEC
M1M80_13115	COG2131	deaminase
M1M80_13120	COG1596	polysaccharide export
M1M80_13120	COG1555	photosystem II stabilization
M1M80_13125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1M80_13130	COG2226	methyltransferase
M1M80_13135	COG0799	negative regulation of ribosome biogenesis
M1M80_13140	COG1713	HD superfamily hydrolase involved in NAD metabolism
M1M80_13145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M1M80_13150	COG1534	Rna-binding protein
M1M80_13155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M1M80_13160	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M1M80_13165	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M1M80_13175	COG2755	lipolytic protein G-D-S-L family
M1M80_13180	COG5632	N-Acetylmuramoyl-L-alanine amidase
M1M80_13180	COG3409	Peptidoglycan-binding domain 1 protein
M1M80_13185	COG0398	Pfam SNARE associated Golgi protein
M1M80_13190	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M1M80_13200	COG3209	COG3209 Rhs family protein
M1M80_13225	COG2814	Major facilitator Superfamily
M1M80_13230	COG2814	Major facilitator Superfamily
M1M80_13235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M1M80_13240	COG1335	isochorismatase
M1M80_13245	COG1522	sequence-specific DNA binding
M1M80_13250	COG1522	sequence-specific DNA binding
M1M80_13255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1M80_13260	COG0730	response to heat
M1M80_13265	COG0425	Belongs to the sulfur carrier protein TusA family
M1M80_13280	COG0425	Belongs to the sulfur carrier protein TusA family
M1M80_13280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1M80_13290	COG2210	Belongs to the sulfur carrier protein TusA family
M1M80_13295	COG1937	Protein conserved in bacteria
M1M80_13320	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_13325	COG1309	transcriptional regulator
M1M80_13330	COG2085	NADP oxidoreductase coenzyme F420-dependent
M1M80_13335	COG1733	regulation of RNA biosynthetic process
M1M80_13360	COG0457	Tetratricopeptide repeat
M1M80_13370	COG5444	nuclease activity
M1M80_13375	COG4282	regulation of fungal-type cell wall biogenesis
M1M80_13390	COG2732	(Barnase) inhibitor
M1M80_13400	COG4824	toxin secretion phage lysis holin
M1M80_13425	COG0563	adenylate kinase activity
M1M80_13435	COG0583	DNA-binding transcription factor activity
M1M80_13445	COG0697	spore germination
M1M80_13450	COG0583	DNA-binding transcription factor activity
M1M80_13455	COG4124	Belongs to the glycosyl hydrolase 26 family
M1M80_13465	COG2207	Transcriptional regulator
M1M80_13465	COG1917	Cupin 2, conserved barrel domain protein
M1M80_13470	COG0697	spore germination
M1M80_13475	COG1802	Transcriptional regulator
M1M80_13480	COG2318	DinB family
M1M80_13485	COG0456	acetyltransferase
M1M80_13490	COG0477	Major facilitator Superfamily
M1M80_13495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1M80_13520	COG0747	negative chemotaxis
M1M80_13525	COG0601	transmembrane transport
M1M80_13530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1M80_13535	COG0444	Belongs to the ABC transporter superfamily
M1M80_13540	COG4608	Belongs to the ABC transporter superfamily
M1M80_13545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1M80_13555	COG3443	Belongs to the bacterial solute-binding protein 9 family
M1M80_13560	COG1595	DNA-templated transcription, initiation
M1M80_13565	COG0667	Aldo Keto reductase
M1M80_13570	COG3409	Peptidoglycan-binding domain 1 protein
M1M80_13575	COG5566	PFAM Mor transcription activator
M1M80_13580	COG0596	Alpha beta hydrolase
M1M80_13585	COG0697	spore germination
M1M80_13590	COG0110	maltose O-acetyltransferase activity
M1M80_13595	COG4991	sh3 domain protein
M1M80_13600	COG4991	sh3 domain protein
M1M80_13610	COG5577	PFAM Coat F domain
M1M80_13615	COG1063	alcohol dehydrogenase
M1M80_13625	COG5577	PFAM Coat F domain
M1M80_13635	COG0667	Aldo Keto reductase
M1M80_13640	COG2207	Transcriptional regulator
M1M80_13645	COG0789	Transcriptional regulator
M1M80_13650	COG0789	Transcriptional regulator
M1M80_13660	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M1M80_13665	COG1064	alcohol dehydrogenase
M1M80_13670	COG0693	protein deglycase activity
M1M80_13675	COG1621	beta-fructofuranosidase activity
M1M80_13685	COG3716	PTS system mannose fructose sorbose family IID component
M1M80_13690	COG3715	PTS system
M1M80_13695	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_13700	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1M80_13705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M1M80_13705	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M1M80_13715	COG1113	amino acid transport
M1M80_13720	COG1280	lysine exporter protein (LysE YggA)
M1M80_13725	COG1378	Sugar-specific transcriptional regulator TrmB
M1M80_13730	COG1595	DNA-templated transcription, initiation
M1M80_13740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M1M80_13740	COG2755	lipolytic protein G-D-S-L family
M1M80_13750	COG2124	cytochrome p450
M1M80_13750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1M80_13755	COG1309	transcriptional regulator
M1M80_13760	COG2226	methyltransferase
M1M80_13775	COG2116	formate transmembrane transporter activity
M1M80_13780	COG5609	conserved protein (DUF2294)
M1M80_13785	COG3383	formate dehydrogenase (NAD+) activity
M1M80_13790	COG2427	Protein of unknown function (DUF1641)
M1M80_13800	COG0626	cystathionine gamma-synthase activity
M1M80_13805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1M80_13810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1M80_13815	COG2226	methyltransferase
M1M80_13830	COG0768	penicillin binding
M1M80_13835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1M80_13840	COG0572	uridine kinase
M1M80_13845	COG0826	peptidase U32
M1M80_13850	COG0826	peptidase U32
M1M80_13855	COG4122	O-methyltransferase activity
M1M80_13860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1M80_13865	COG3906	Belongs to the UPF0473 family
M1M80_13870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1M80_13875	COG4472	Bacterial protein of unknown function (DUF965)
M1M80_13880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1M80_13885	COG0628	permease
M1M80_13890	COG1126	abc transporter atp-binding protein
M1M80_13895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1M80_13900	COG0765	amino acid transport
M1M80_13905	COG0765	amino acid transport
M1M80_13920	COG3881	PFAM PRC-barrel domain
M1M80_13925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1M80_13930	COG0457	Tetratricopeptide repeat
M1M80_13935	COG0482	sulfurtransferase activity
M1M80_13940	COG1104	cysteine desulfurase activity
M1M80_13945	COG1959	2 iron, 2 sulfur cluster binding
M1M80_13950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1M80_13955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1M80_13965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M1M80_13970	COG0124	histidyl-tRNA synthetase
M1M80_13980	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1M80_13980	COG3103	Sh3 type 3 domain protein
M1M80_13980	COG4991	sh3 domain protein
M1M80_13985	COG1490	D-aminoacyl-tRNA deacylase activity
M1M80_13990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1M80_13995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M1M80_14000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1M80_14000	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M1M80_14005	COG5416	Lipopolysaccharide assembly protein A domain
M1M80_14010	COG0490	domain, Protein
M1M80_14015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1M80_14015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1M80_14025	COG2244	polysaccharide biosynthetic process
M1M80_14030	COG2323	membrane
M1M80_14040	COG1862	Preprotein translocase
M1M80_14045	COG0343	queuine tRNA-ribosyltransferase activity
M1M80_14050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M1M80_14060	COG2255	four-way junction helicase activity
M1M80_14065	COG0632	four-way junction helicase activity
M1M80_14075	COG2814	Major facilitator Superfamily
M1M80_14080	COG0673	inositol 2-dehydrogenase activity
M1M80_14085	COG2112	serine threonine protein kinase
M1M80_14105	COG1115	amino acid carrier protein
M1M80_14110	COG0217	transcriptional regulatory protein
M1M80_14120	COG1388	LysM domain
M1M80_14125	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1M80_14130	COG0157	Belongs to the NadC ModD family
M1M80_14135	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M1M80_14140	COG1104	cysteine desulfurase activity
M1M80_14145	COG1827	regulation of RNA biosynthetic process
M1M80_14150	COG0077	Prephenate dehydratase
M1M80_14155	COG4492	Belongs to the UPF0735 family
M1M80_14160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M1M80_14165	COG3290	protein histidine kinase activity
M1M80_14175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M1M80_14180	COG2868	ribosomal protein
M1M80_14185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M1M80_14190	COG1994	Peptidase M50
M1M80_14195	COG0739	heme binding
M1M80_14200	COG2894	cell division
M1M80_14205	COG0850	regulation of cytokinetic process
M1M80_14210	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1M80_14220	COG1077	Cell shape determining protein MreB Mrl
M1M80_14265	COG0457	Tetratricopeptide repeat
M1M80_14270	COG5444	nuclease activity
M1M80_14280	COG5632	N-Acetylmuramoyl-L-alanine amidase
M1M80_14280	COG3409	Peptidoglycan-binding domain 1 protein
M1M80_14280	COG1388	LysM domain
M1M80_14325	COG1705	Flagellar rod assembly protein muramidase FlgJ
M1M80_14335	COG5280	Phage tail tape measure protein TP901
M1M80_14335	COG3953	SLT domain
M1M80_14515	COG0424	maF-like protein
M1M80_14525	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1M80_14530	COG0285	dihydrofolate synthase activity
M1M80_14535	COG0525	valine-tRNA ligase activity
M1M80_14545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1M80_14550	COG1388	LysM domain
M1M80_14555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M1M80_14560	COG0113	porphobilinogen synthase activity
M1M80_14565	COG1587	Uroporphyrinogen-III synthase
M1M80_14570	COG0181	hydroxymethylbilane synthase activity
M1M80_14575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M1M80_14580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M1M80_14590	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M1M80_14595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M1M80_14600	COG1067	ATP-dependent peptidase activity
M1M80_14600	COG0470	DNA polymerase III
M1M80_14605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M1M80_14610	COG0544	peptidyl-prolyl cis-trans isomerase activity
M1M80_14615	COG1477	protein flavinylation
M1M80_14615	COG0457	Tetratricopeptide repeat
M1M80_14620	COG0066	3-isopropylmalate dehydratase activity
M1M80_14625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M1M80_14630	COG0473	3-isopropylmalate dehydrogenase activity
M1M80_14635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1M80_14640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M1M80_14645	COG0440	acetolactate synthase activity
M1M80_14650	COG0028	Belongs to the TPP enzyme family
M1M80_14660	COG0454	-acetyltransferase
M1M80_14665	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
M1M80_14675	COG0622	Phosphoesterase
M1M80_14680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M1M80_14685	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M1M80_14690	COG5401	PFAM Sporulation and spore germination
M1M80_14695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1M80_14700	COG1846	Transcriptional regulator
M1M80_14705	COG2197	response regulator
M1M80_14710	COG0824	Thioesterase
M1M80_14715	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1M80_14720	COG1053	succinate dehydrogenase
M1M80_14725	COG2009	succinate dehydrogenase
M1M80_14730	COG1719	4-vinyl reductase, 4VR
M1M80_14735	COG0527	aspartate kinase activity
M1M80_14740	COG0322	excinuclease ABC activity
M1M80_14745	COG3118	belongs to the thioredoxin family
M1M80_14750	COG3534	alpha-L-arabinofuranosidase
M1M80_14755	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M1M80_14760	COG2086	electron transfer activity
M1M80_14765	COG1024	Enoyl-CoA hydratase
M1M80_14770	COG1309	transcriptional regulator
M1M80_14775	COG0318	PFAM AMP-dependent synthetase and ligase
M1M80_14780	COG3766	membrane
M1M80_14785	COG1193	negative regulation of DNA recombination
M1M80_14790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M1M80_14790	COG1796	DNA polymerase
M1M80_14795	COG1286	toxin biosynthetic process
M1M80_14800	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M1M80_14805	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1M80_14810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1M80_14810	COG0072	phenylalanine-tRNA ligase activity
M1M80_14815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M1M80_14825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1M80_14835	COG3835	regulator
M1M80_14840	COG0277	FAD linked oxidase domain protein
M1M80_14845	COG0247	lactate metabolic process
M1M80_14850	COG0346	lactoylglutathione lyase activity
M1M80_14860	COG1966	Carbon starvation protein
M1M80_14875	COG1695	Transcriptional regulator
M1M80_14880	COG3534	alpha-L-arabinofuranosidase
M1M80_14885	COG0395	ABC-type sugar transport system, permease component
M1M80_14890	COG1175	transmembrane transport
M1M80_14895	COG1653	transport
M1M80_14900	COG0371	Dehydrogenase
M1M80_14905	COG0647	UMP catabolic process
M1M80_14910	COG0235	Class ii aldolase
M1M80_14915	COG1069	ribulokinase activity
M1M80_14920	COG2160	L-arabinose isomerase activity
M1M80_14925	COG3507	Belongs to the glycosyl hydrolase 43 family
M1M80_14930	COG1363	Peptidase, m42
M1M80_14940	COG3326	Membrane
M1M80_14945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M1M80_14950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M1M80_14955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M1M80_14965	COG1346	cytolysis
M1M80_14970	COG1380	Effector of murein hydrolase LrgA
M1M80_14975	COG3279	Response regulator of the LytR AlgR family
M1M80_14980	COG3275	phosphorelay sensor kinase activity
M1M80_14985	COG1011	Hydrolase
M1M80_14990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1M80_15000	COG0398	Pfam SNARE associated Golgi protein
M1M80_15005	COG1484	DNA-dependent DNA replication
M1M80_15010	COG3611	Membrane attachment protein
M1M80_15015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1M80_15020	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M1M80_15025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1M80_15030	COG1733	regulation of RNA biosynthetic process
M1M80_15035	COG2814	Major facilitator Superfamily
M1M80_15040	COG0656	L-ascorbic acid biosynthetic process
M1M80_15045	COG0237	dephospho-CoA kinase activity
M1M80_15050	COG1971	Probably functions as a manganese efflux pump
M1M80_15055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M1M80_15060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1M80_15060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1M80_15065	COG5002	protein histidine kinase activity
M1M80_15070	COG0745	RESPONSE REGULATOR receiver
M1M80_15075	COG0039	L-malate dehydrogenase activity
M1M80_15080	COG0538	isocitrate dehydrogenase activity
M1M80_15085	COG0372	Belongs to the citrate synthase family
M1M80_15090	COG2707	UPF0756 membrane protein
M1M80_15095	COG0628	permease
M1M80_15100	COG3030	protein affecting phage T7 exclusion by the F plasmid
M1M80_15105	COG0469	pyruvate kinase activity
M1M80_15110	COG0205	6-phosphofructokinase activity
M1M80_15115	COG0825	malonyl-CoA metabolic process
M1M80_15120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M1M80_15125	COG0281	malic enzyme
M1M80_15130	COG0587	DNA-directed DNA polymerase activity
M1M80_15150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M1M80_15160	COG4109	DRTGG domain
M1M80_15165	COG0730	response to heat
M1M80_15175	COG0196	riboflavin kinase activity
M1M80_15180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1M80_15185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1M80_15190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1M80_15195	COG1126	abc transporter atp-binding protein
M1M80_15200	COG0765	amino acid transport
M1M80_15205	COG0765	amino acid transport
M1M80_15210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1M80_15215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1M80_15220	COG0454	-acetyltransferase
M1M80_15225	COG0583	DNA-binding transcription factor activity
M1M80_15230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M1M80_15235	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_15240	COG0165	Argininosuccinate lyase
M1M80_15245	COG0137	argininosuccinate synthase activity
M1M80_15250	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1M80_15255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1M80_15260	COG0827	DNA restriction-modification system
M1M80_15265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M1M80_15270	COG3874	Sporulation protein YtfJ
M1M80_15280	COG1714	RDD family
M1M80_15285	COG0616	signal peptide processing
M1M80_15290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1M80_15295	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M1M80_15300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1M80_15310	COG0301	tRNA thio-modification
M1M80_15315	COG1104	cysteine desulfurase activity
M1M80_15320	COG1114	Component of the transport system for branched-chain amino acids
M1M80_15325	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M1M80_15330	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M1M80_15335	COG1309	transcriptional regulator
M1M80_15340	COG1956	GAF domain-containing protein
M1M80_15345	COG2199	diguanylate cyclase activity
M1M80_15345	COG2203	Gaf domain
M1M80_15350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M1M80_15355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1M80_15360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1M80_15365	COG0454	-acetyltransferase
M1M80_15370	COG0517	IMP dehydrogenase activity
M1M80_15375	COG0123	including yeast histone deacetylase and acetoin utilization protein
M1M80_15380	COG1360	Flagellar Motor Protein
M1M80_15385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M1M80_15390	COG1609	Transcriptional regulator
M1M80_15395	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M1M80_15395	COG1605	Chorismate mutase
M1M80_15400	COG3118	belongs to the thioredoxin family
M1M80_15405	COG4980	gas vesicle protein
M1M80_15410	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M1M80_15415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1M80_15420	COG1674	ftsk spoiiie
M1M80_15425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1M80_15430	COG4848	Belongs to the UPF0354 family
M1M80_15435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1M80_15450	COG1363	Peptidase, m42
M1M80_15455	COG5584	Small secreted protein
M1M80_15460	COG0281	malic enzyme
M1M80_15465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1M80_15470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1M80_15480	COG0510	thiamine kinase activity
M1M80_15485	COG1523	belongs to the glycosyl hydrolase 13 family
M1M80_15490	COG1597	lipid kinase activity
M1M80_15500	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M1M80_15505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1M80_15510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1M80_15515	COG2252	PERMEase
M1M80_15520	COG4473	ABC transporter
M1M80_15525	COG1131	(ABC) transporter
M1M80_15530	COG1349	DNA-binding transcription factor activity
M1M80_15535	COG1187	pseudouridine synthase activity
M1M80_15540	COG2244	polysaccharide biosynthetic process
M1M80_15545	COG2081	HI0933 family
M1M80_15550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1M80_15560	COG5578	integral membrane protein
M1M80_15565	COG0673	inositol 2-dehydrogenase activity
M1M80_15570	COG1653	transport
M1M80_15575	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M1M80_15580	COG4209	transmembrane transport
M1M80_15585	COG2207	Transcriptional regulator
M1M80_15590	COG1653	transport
M1M80_15595	COG0395	ABC-type sugar transport system, permease component
M1M80_15600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1M80_15605	COG2124	cytochrome p450
M1M80_15610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M1M80_15620	COG0156	8-amino-7-oxononanoate synthase activity
M1M80_15625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M1M80_15630	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
M1M80_15640	COG1073	alpha beta
M1M80_15645	COG1609	Transcriptional regulator
M1M80_15650	COG1653	transport
M1M80_15655	COG1175	transmembrane transport
M1M80_15660	COG0395	ABC-type sugar transport system, permease component
M1M80_15665	COG1486	melibiose metabolic process
M1M80_15670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1M80_15675	COG0495	leucyl-tRNA aminoacylation
M1M80_15685	COG2202	Pas domain
M1M80_15685	COG1366	Belongs to the anti-sigma-factor antagonist family
M1M80_15690	COG2814	Major facilitator Superfamily
M1M80_15695	COG2433	Pfam Transposase IS66
M1M80_15700	COG0577	efflux transmembrane transporter activity
M1M80_15705	COG1136	(ABC) transporter
M1M80_15710	COG2205	protein histidine kinase activity
M1M80_15715	COG0745	RESPONSE REGULATOR receiver
M1M80_15720	COG0577	efflux transmembrane transporter activity
M1M80_15725	COG1136	(ABC) transporter
M1M80_15740	COG1131	(ABC) transporter
M1M80_15745	COG1725	Transcriptional regulator
M1M80_15760	COG1242	4 iron, 4 sulfur cluster binding
M1M80_15765	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M1M80_15775	COG2267	carboxylic ester hydrolase activity
M1M80_15780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1M80_15785	COG1113	amino acid transport
M1M80_15790	COG0367	asparagine synthase
M1M80_15795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M1M80_15800	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M1M80_15810	COG1506	peptidase
M1M80_15815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1M80_15820	COG1116	anion transmembrane transporter activity
M1M80_15825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1M80_15830	COG0494	nUDIX hydrolase
M1M80_15835	COG4824	toxin secretion phage lysis holin
M1M80_15840	COG0783	Belongs to the Dps family
M1M80_15855	COG1854	S-ribosylhomocysteine lyase activity
M1M80_15860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M1M80_15865	COG0288	reversible hydration of carbon dioxide
M1M80_15870	COG0254	rRNA binding
M1M80_15875	COG1271	oxidase subunit
M1M80_15880	COG1294	oxidase, subunit
M1M80_15890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1M80_15895	COG1321	iron dependent repressor
M1M80_15895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1M80_15900	COG1121	(ABC) transporter
M1M80_15905	COG0803	Belongs to the bacterial solute-binding protein 9 family
M1M80_15910	COG4948	Mandelate Racemase Muconate Lactonizing
M1M80_15915	COG0318	PFAM AMP-dependent synthetase and ligase
M1M80_15920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M1M80_15925	COG0596	Alpha beta hydrolase
M1M80_15930	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M1M80_15935	COG1169	isochorismate synthase
M1M80_15940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1M80_15945	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M1M80_15950	COG0058	SHG alpha-glucan phosphorylase activity
M1M80_15955	COG0297	glycogen (starch) synthase activity
M1M80_15960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M1M80_15965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M1M80_15970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M1M80_16095	COG3859	Proton-coupled thiamine transporter YuaJ
M1M80_16100	COG1247	-acetyltransferase
M1M80_16105	COG2268	Band 7 protein
M1M80_16110	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1M80_16115	COG2318	DinB family
M1M80_16125	COG1454	alcohol dehydrogenase
M1M80_16130	COG1012	belongs to the aldehyde dehydrogenase family
M1M80_16135	COG1510	regulation of RNA biosynthetic process
M1M80_16145	COG0569	domain protein
M1M80_16150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1M80_16155	COG4682	membrane
M1M80_16160	COG1705	Flagellar rod assembly protein muramidase FlgJ
M1M80_16165	COG0477	Major facilitator Superfamily
M1M80_16170	COG5553	Cysteine dioxygenase type I
M1M80_16180	COG1968	undecaprenyl-diphosphatase activity
M1M80_16185	COG0628	permease
M1M80_16190	COG0673	inositol 2-dehydrogenase activity
M1M80_16195	COG4806	L-rhamnose isomerase
M1M80_16200	COG3254	rhamnose metabolic process
M1M80_16205	COG1070	Carbohydrate kinase
M1M80_16210	COG1349	DNA-binding transcription factor activity
M1M80_16215	COG3347	Dehydrogenase
M1M80_16215	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_16220	COG0840	transmembrane signaling receptor activity
M1M80_16225	COG0840	transmembrane signaling receptor activity
M1M80_16235	COG0840	transmembrane signaling receptor activity
M1M80_16250	COG2070	2-Nitropropane dioxygenase
M1M80_16255	COG0432	Pfam Uncharacterised protein family UPF0047
M1M80_16260	COG0366	Alpha amylase catalytic
M1M80_16265	COG1253	flavin adenine dinucleotide binding
M1M80_16270	COG2738	Putative neutral zinc metallopeptidase
M1M80_16285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1M80_16300	COG0166	Belongs to the GPI family
M1M80_16305	COG1979	alcohol dehydrogenase
M1M80_16310	COG1979	alcohol dehydrogenase
M1M80_16315	COG2155	Conserved Protein
M1M80_16320	COG1098	S1 RNA binding domain
M1M80_16325	COG0436	Aminotransferase
M1M80_16330	COG1522	sequence-specific DNA binding
M1M80_16335	COG2267	carboxylic ester hydrolase activity
M1M80_16345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M1M80_16350	COG2205	protein histidine kinase activity
M1M80_16360	COG5018	Exonuclease
M1M80_16370	COG2814	Major facilitator Superfamily
M1M80_16375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1M80_16380	COG3011	Protein conserved in bacteria
M1M80_16390	COG3290	protein histidine kinase activity
M1M80_16395	COG4565	transcriptional regulatory protein
M1M80_16400	COG1744	ABC transporter substrate-binding protein PnrA-like
M1M80_16405	COG3845	ABC transporter
M1M80_16410	COG4603	Belongs to the binding-protein-dependent transport system permease family
M1M80_16415	COG1079	Belongs to the binding-protein-dependent transport system permease family
M1M80_16420	COG3493	citrate carrier protein
M1M80_16430	COG2111	Na H antiporter
M1M80_16430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1M80_16435	COG2111	Na H antiporter
M1M80_16440	COG1006	Multisubunit Na H antiporter MnhC subunit
M1M80_16445	COG0651	ATP synthesis coupled electron transport
M1M80_16450	COG1863	multisubunit Na H antiporter MnhE subunit
M1M80_16455	COG2212	antiporter activity
M1M80_16460	COG1320	monovalent cation:proton antiporter activity
M1M80_16465	COG2050	protein possibly involved in aromatic compounds catabolism
M1M80_16475	COG4585	Histidine kinase
M1M80_16485	COG0142	geranyltranstransferase activity
M1M80_16505	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M1M80_16510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M1M80_16515	COG1335	isochorismatase
M1M80_16520	COG5506	Protein of unknown function (DUF1694)
M1M80_16535	COG0628	permease
M1M80_16550	COG1418	mRNA catabolic process
M1M80_16555	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_16565	COG1511	domain protein
M1M80_16570	COG1674	ftsk spoiiie
M1M80_16570	COG0433	COG0433 Predicted ATPase
M1M80_16575	COG4499	WXG100 protein secretion system (Wss), protein YukC
M1M80_16580	COG5417	Belongs to the EsaB family
M1M80_16585	COG4842	Belongs to the WXG100 family
M1M80_16590	COG2508	Transcriptional regulator
M1M80_16590	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1M80_16595	COG0686	Belongs to the AlaDH PNT family
M1M80_16600	COG5634	Uncharacterized conserved protein (DUF2278)
M1M80_16605	COG3251	PFAM MbtH domain protein
M1M80_16610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_16615	COG3433	isochorismatase activity
M1M80_16615	COG1535	isochorismatase
M1M80_16620	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1M80_16625	COG1169	isochorismate synthase
M1M80_16630	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_16635	COG2819	hydrolase of the alpha beta superfamily
M1M80_16640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M1M80_16645	COG1268	BioY protein
M1M80_16650	COG2056	Na+-H+ antiporter family
M1M80_16655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M1M80_16660	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M1M80_16665	COG3584	3D domain protein
M1M80_16680	COG1252	NADH dehydrogenase
M1M80_16685	COG0492	ferredoxin-NADP+ reductase activity
M1M80_16695	COG0516	GMP reductase activity
M1M80_16700	COG2808	Putative FMN-binding domain
M1M80_16705	COG0456	acetyltransferase
M1M80_16710	COG0316	Belongs to the HesB IscA family
M1M80_16715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M1M80_16720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1M80_16725	COG4844	belongs to the
M1M80_16730	COG1252	NADH dehydrogenase
M1M80_16735	COG4837	Protein of unknown function (DUF1462)
M1M80_16740	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M1M80_16745	COG0823	Involved in the tonB-independent uptake of proteins
M1M80_16745	COG4946	Tricorn protease homolog
M1M80_16745	COG1506	peptidase
M1M80_16750	COG0083	homoserine kinase activity
M1M80_16755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1M80_16760	COG0460	homoserine dehydrogenase
M1M80_16765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1M80_16770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1M80_16775	COG0647	UMP catabolic process
M1M80_16780	COG2445	Protein of unknown function DUF86
M1M80_16785	COG4470	Protein conserved in bacteria
M1M80_16795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1M80_16800	COG0739	heme binding
M1M80_16810	COG3377	Domain of unknown function (DUF1805)
M1M80_16815	COG0737	Belongs to the 5'-nucleotidase family
M1M80_16820	COG0730	response to heat
M1M80_16825	COG1801	Protein of unknown function DUF72
M1M80_16835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M1M80_16840	COG2508	Transcriptional regulator
M1M80_16845	COG2233	PERMEase
M1M80_16850	COG2233	PERMEase
M1M80_16855	COG3195	allantoin biosynthetic process
M1M80_16855	COG3648	Uricase
M1M80_16860	COG2351	hydroxyisourate hydrolase activity
M1M80_16885	COG2080	2 iron, 2 sulfur cluster binding
M1M80_16890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1M80_16895	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M1M80_16900	COG2068	MobA-Related Protein
M1M80_16905	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M1M80_16910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1M80_16915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1M80_16925	COG2356	endonuclease I
M1M80_16930	COG3842	ATPase activity
M1M80_16935	COG2188	Transcriptional regulator
M1M80_16940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1M80_16945	COG0395	ABC-type sugar transport system, permease component
M1M80_16950	COG1175	transmembrane transport
M1M80_16955	COG1653	transport
M1M80_16960	COG2222	sugar isomerase
M1M80_16965	COG0322	excinuclease ABC activity
M1M80_16970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1M80_16985	COG0346	lactoylglutathione lyase activity
M1M80_16990	COG0640	Transcriptional regulator
M1M80_16995	COG0719	Fe-S assembly protein
M1M80_17000	COG0822	iron-sulfur transferase activity
M1M80_17005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1M80_17010	COG0719	Fe-S assembly protein
M1M80_17015	COG0396	ATPase activity
M1M80_17025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1M80_17030	COG1464	Belongs to the NlpA lipoprotein family
M1M80_17035	COG2011	ABC-type metal ion transport system permease component
M1M80_17040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1M80_17050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1M80_17055	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M1M80_17065	COG0509	glycine decarboxylation via glycine cleavage system
M1M80_17070	COG1393	Belongs to the ArsC family
M1M80_17075	COG1960	acyl-CoA dehydrogenase activity
M1M80_17080	COG0183	Belongs to the thiolase family
M1M80_17085	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1M80_17085	COG1024	Enoyl-CoA hydratase
M1M80_17095	COG0506	proline dehydrogenase activity
M1M80_17105	COG5577	PFAM Coat F domain
M1M80_17110	COG1846	Transcriptional regulator
M1M80_17115	COG0477	Major facilitator Superfamily
M1M80_17120	COG1942	4-Oxalocrotonate Tautomerase
M1M80_17125	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_17130	COG0583	DNA-binding transcription factor activity
M1M80_17140	COG1120	ATPase activity
M1M80_17155	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_17160	COG0783	Belongs to the Dps family
M1M80_17165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1M80_17170	COG0745	RESPONSE REGULATOR receiver
M1M80_17175	COG2770	Histidine kinase
M1M80_17175	COG2205	protein histidine kinase activity
M1M80_17185	COG1309	transcriptional regulator
M1M80_17190	COG0114	fumarate hydratase activity
M1M80_17200	COG0697	spore germination
M1M80_17205	COG0814	amino acid
M1M80_17215	COG2197	response regulator
M1M80_17220	COG4585	Histidine kinase
M1M80_17225	COG4758	membrane
M1M80_17230	COG3595	metallopeptidase activity
M1M80_17235	COG1842	Phage shock protein A
M1M80_17240	COG4758	membrane
M1M80_17245	COG2814	Major facilitator Superfamily
M1M80_17250	COG2096	Adenosyltransferase
M1M80_17255	COG1120	ATPase activity
M1M80_17260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1M80_17265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1M80_17270	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_17275	COG3386	PFAM SMP-30 Gluconolaconase
M1M80_17280	COG2205	protein histidine kinase activity
M1M80_17285	COG0745	RESPONSE REGULATOR receiver
M1M80_17295	COG1191	sigma factor activity
M1M80_17305	COG2140	Oxalate decarboxylase
M1M80_17315	COG0577	efflux transmembrane transporter activity
M1M80_17320	COG1136	(ABC) transporter
M1M80_17325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1M80_17330	COG1120	ATPase activity
M1M80_17335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1M80_17340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1M80_17345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1M80_17350	COG0640	Transcriptional regulator
M1M80_17365	COG0531	amino acid
M1M80_17375	COG1988	membrane-bound metal-dependent
M1M80_17380	COG1368	sulfuric ester hydrolase activity
M1M80_17385	COG1910	domain protein
M1M80_17390	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1M80_17395	COG4149	molybdate abc transporter
M1M80_17400	COG0656	L-ascorbic acid biosynthetic process
M1M80_17410	COG0025	NhaP-type Na H and K H
M1M80_17415	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1M80_17420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1M80_17425	COG3973	AAA domain
M1M80_17430	COG2860	membrane
M1M80_17435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M1M80_17440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1M80_17445	COG2217	Heavy metal translocating P-type atpase
M1M80_17450	COG2217	Heavy metal translocating P-type atpase
M1M80_17455	COG2608	mercury ion transmembrane transporter activity
M1M80_17460	COG1937	Protein conserved in bacteria
M1M80_17465	COG0673	inositol 2-dehydrogenase activity
M1M80_17470	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1M80_17475	COG1289	transmembrane transporter activity
M1M80_17490	COG2076	Multidrug Resistance protein
M1M80_17495	COG1309	transcriptional regulator
M1M80_17500	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_17520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M1M80_17525	COG0557	exoribonuclease II activity
M1M80_17530	COG1647	Serine aminopeptidase, S33
M1M80_17535	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M1M80_17540	COG0596	Alpha beta hydrolase
M1M80_17545	COG1476	TRANSCRIPTIONal
M1M80_17550	COG1396	sequence-specific DNA binding
M1M80_17555	COG1396	sequence-specific DNA binding
M1M80_17560	COG1733	regulation of RNA biosynthetic process
M1M80_17565	COG0840	transmembrane signaling receptor activity
M1M80_17570	COG1174	glycine betaine transport
M1M80_17575	COG1732	Glycine betaine
M1M80_17580	COG1174	glycine betaine transport
M1M80_17585	COG1125	glycine betaine transport
M1M80_17585	COG0517	IMP dehydrogenase activity
M1M80_17590	COG1510	regulation of RNA biosynthetic process
M1M80_17595	COG1174	glycine betaine transport
M1M80_17600	COG1732	Glycine betaine
M1M80_17605	COG1174	glycine betaine transport
M1M80_17610	COG1125	glycine betaine transport
M1M80_17610	COG0517	IMP dehydrogenase activity
M1M80_17615	COG1510	regulation of RNA biosynthetic process
M1M80_17625	COG3064	Membrane
M1M80_17630	COG4640	response to antibiotic
M1M80_17635	COG0456	acetyltransferase
M1M80_17645	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1M80_17655	COG0126	phosphoglycerate kinase activity
M1M80_17660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1M80_17665	COG2390	Transcriptional regulator
M1M80_17670	COG2814	Major facilitator Superfamily
M1M80_17675	COG1609	Transcriptional regulator
M1M80_17680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1M80_17685	COG0583	DNA-binding transcription factor activity
M1M80_17690	COG0697	spore germination
M1M80_17695	COG1113	amino acid transport
M1M80_17700	COG3858	chitin binding
M1M80_17705	COG1556	Lactate utilization protein
M1M80_17710	COG1139	Iron-sulfur cluster binding protein
M1M80_17715	COG0247	lactate metabolic process
M1M80_17720	COG2197	response regulator
M1M80_17725	COG4585	Histidine kinase
M1M80_17730	COG0842	Transport permease protein
M1M80_17735	COG1131	(ABC) transporter
M1M80_17740	COG0596	Alpha beta hydrolase
M1M80_17745	COG2208	phosphoserine phosphatase activity
M1M80_17750	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M1M80_17755	COG1874	Beta-galactosidase
M1M80_17760	COG3833	ABC-type maltose transport systems, permease component
M1M80_17765	COG1175	transmembrane transport
M1M80_17770	COG2182	Extracellular solute-binding protein
M1M80_17775	COG1609	Transcriptional regulator
M1M80_17780	COG2186	Transcriptional regulator
M1M80_17785	COG1620	l-lactate permease
M1M80_17790	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M1M80_17800	COG5039	Polysaccharide pyruvyl transferase
M1M80_17805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1M80_17810	COG0110	maltose O-acetyltransferase activity
M1M80_17815	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1M80_17820	COG2244	polysaccharide biosynthetic process
M1M80_17825	COG1216	Glycosyl transferase, family 2
M1M80_17830	COG5039	Polysaccharide pyruvyl transferase
M1M80_17835	COG1216	Glycosyl transferase, family 2
M1M80_17845	COG0438	transferase activity, transferring glycosyl groups
M1M80_17850	COG1215	transferase activity, transferring glycosyl groups
M1M80_17855	COG0438	transferase activity, transferring glycosyl groups
M1M80_17860	COG1086	Polysaccharide biosynthesis protein
M1M80_17865	COG0489	protein tyrosine kinase activity
M1M80_17870	COG3944	biosynthesis protein
M1M80_17875	COG1396	sequence-specific DNA binding
M1M80_17880	COG2272	Belongs to the type-B carboxylesterase lipase family
M1M80_17890	COG3479	Phenolic acid decarboxylase
M1M80_17900	COG1794	racemase activity, acting on amino acids and derivatives
M1M80_17905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1M80_17915	COG1621	beta-fructofuranosidase activity
M1M80_17920	COG1621	beta-fructofuranosidase activity
M1M80_17925	COG0531	amino acid
M1M80_17930	COG1309	transcriptional regulator
M1M80_17935	COG2076	Multidrug Resistance protein
M1M80_17940	COG2076	Multidrug Resistance protein
M1M80_17960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1M80_17965	COG0366	Alpha amylase catalytic
M1M80_17970	COG1554	hydrolase, family 65, central catalytic
M1M80_17980	COG3833	ABC-type maltose transport systems, permease component
M1M80_17985	COG1175	transmembrane transport
M1M80_17990	COG2182	Extracellular solute-binding protein
M1M80_17995	COG0366	Alpha amylase catalytic
M1M80_18000	COG1609	Transcriptional regulator
M1M80_18005	COG1611	Belongs to the LOG family
M1M80_18010	COG1694	Mazg nucleotide pyrophosphohydrolase
M1M80_18015	COG0659	secondary active sulfate transmembrane transporter activity
M1M80_18020	COG0288	reversible hydration of carbon dioxide
M1M80_18025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M1M80_18030	COG0577	efflux transmembrane transporter activity
M1M80_18035	COG1136	(ABC) transporter
M1M80_18040	COG5002	protein histidine kinase activity
M1M80_18045	COG0745	RESPONSE REGULATOR receiver
M1M80_18055	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M1M80_18060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1M80_18065	COG1481	regulation of sporulation
M1M80_18070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M1M80_18075	COG1660	Displays ATPase and GTPase activities
M1M80_18080	COG1051	belongs to the nudix hydrolase family
M1M80_18085	COG0492	ferredoxin-NADP+ reductase activity
M1M80_18090	COG3883	PFAM NLP P60 protein
M1M80_18090	COG0791	NLP P60 protein
M1M80_18095	COG0457	Tetratricopeptide repeat
M1M80_18100	COG1132	(ABC) transporter
M1M80_18120	COG0140	phosphoribosyl-ATP diphosphatase activity
M1M80_18120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1M80_18125	COG0107	imidazoleglycerol-phosphate synthase activity
M1M80_18130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M1M80_18135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1M80_18140	COG0131	Imidazoleglycerol-phosphate dehydratase
M1M80_18145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1M80_18150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1M80_18155	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M1M80_18160	COG4990	cell redox homeostasis
M1M80_18165	COG5297	Belongs to the glycosyl hydrolase family 6
M1M80_18170	COG0110	maltose O-acetyltransferase activity
M1M80_18175	COG0546	phosphoglycolate phosphatase activity
M1M80_18180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M1M80_18185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M1M80_18190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M1M80_18195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M1M80_18200	COG0363	glucosamine-6-phosphate deaminase activity
M1M80_18205	COG2188	Transcriptional regulator
M1M80_18210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1M80_18215	COG1846	Transcriptional regulator
M1M80_18220	COG2814	Major facilitator Superfamily
M1M80_18230	COG1950	PFAM Membrane protein of
M1M80_18235	COG1983	PspC domain protein
M1M80_18240	COG3595	metallopeptidase activity
M1M80_18255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M1M80_18260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1M80_18265	COG0556	nucleotide-excision repair
M1M80_18270	COG4897	Protein conserved in bacteria
M1M80_18280	COG3848	Pyruvate phosphate dikinase
M1M80_18280	COG0574	Belongs to the PEP-utilizing enzyme family
M1M80_18285	COG1309	transcriptional regulator
M1M80_18290	COG2814	Major facilitator Superfamily
M1M80_18295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1M80_18305	COG0793	Belongs to the peptidase S41A family
M1M80_18305	COG3409	Peptidoglycan-binding domain 1 protein
M1M80_18310	COG2177	Part of the ABC transporter FtsEX involved in
M1M80_18315	COG2884	Cell division ATP-binding protein ftsE
M1M80_18320	COG2010	Cytochrome c
M1M80_18325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1M80_18335	COG0653	protein targeting
M1M80_18340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M1M80_18355	COG1516	flagellar protein fliS
M1M80_18360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M1M80_18365	COG1334	flagellar protein FlaG
M1M80_18370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M1M80_18375	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M1M80_18380	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
M1M80_18390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M1M80_18395	COG1256	bacterial-type flagellum assembly
M1M80_18395	COG4786	Flagellar basal body rod
M1M80_18400	COG3418	PFAM FlgN family protein
M1M80_18405	COG2747	anti-sigma28 factor FlgM
M1M80_18415	COG1040	competence protein
M1M80_18425	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M1M80_18430	COG1307	EDD domain protein, DegV family
M1M80_18435	COG2197	response regulator
M1M80_18440	COG4585	Histidine kinase
M1M80_18445	COG1739	Uncharacterized protein family UPF0029
M1M80_18450	COG1316	TRANSCRIPTIONal
M1M80_18455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M1M80_18460	COG0438	transferase activity, transferring glycosyl groups
M1M80_18465	COG1215	transferase activity, transferring glycosyl groups
M1M80_18470	COG3206	protein involved in exopolysaccharide biosynthesis
M1M80_18475	COG3307	-O-antigen
M1M80_18480	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M1M80_18485	COG0438	transferase activity, transferring glycosyl groups
M1M80_18485	COG0297	glycogen (starch) synthase activity
M1M80_18490	COG2244	polysaccharide biosynthetic process
M1M80_18505	COG2247	cell wall binding repeat
M1M80_18505	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1M80_18510	COG2247	cell wall binding repeat
M1M80_18510	COG2385	sporulation resulting in formation of a cellular spore
M1M80_18520	COG1316	TRANSCRIPTIONal
M1M80_18525	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M1M80_18550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1M80_18555	COG1134	teichoic acid transport
M1M80_18560	COG1682	transport, permease protein
M1M80_18565	COG1215	transferase activity, transferring glycosyl groups
M1M80_18575	COG1181	Belongs to the D-alanine--D-alanine ligase family
M1M80_18580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M1M80_18580	COG0463	Glycosyl transferase, family 2
M1M80_18590	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M1M80_18600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M1M80_18635	COG4193	domain, Protein
M1M80_18640	COG1482	cell wall glycoprotein biosynthetic process
M1M80_18645	COG0697	spore germination
M1M80_18650	COG0814	amino acid
M1M80_18660	COG2814	Major facilitator Superfamily
M1M80_18665	COG1316	TRANSCRIPTIONal
M1M80_18670	COG0561	phosphatase activity
M1M80_18675	COG0791	NLP P60 protein
M1M80_18685	COG2843	Capsule synthesis protein
M1M80_18695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M1M80_18700	COG1609	Transcriptional regulator
M1M80_18705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1M80_18710	COG1869	D-ribose catabolic process
M1M80_18715	COG1129	ABC transporter
M1M80_18720	COG1172	Belongs to the binding-protein-dependent transport system permease family
M1M80_18725	COG1879	ABC-type sugar transport system periplasmic component
M1M80_18730	COG3103	Sh3 type 3 domain protein
M1M80_18740	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1M80_18745	COG3527	Alpha-acetolactate decarboxylase
M1M80_18750	COG0028	Belongs to the TPP enzyme family
M1M80_18755	COG0583	DNA-binding transcription factor activity
M1M80_18760	COG5337	Spore coat protein CotH
M1M80_18770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1M80_18780	COG0405	Gamma-glutamyltransferase
M1M80_18785	COG1522	sequence-specific DNA binding
M1M80_18790	COG2059	Chromate
M1M80_18795	COG2059	Chromate
M1M80_18805	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1M80_18810	COG0583	DNA-binding transcription factor activity
M1M80_18830	COG5444	nuclease activity
M1M80_18845	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M1M80_18850	COG4464	protein tyrosine phosphatase activity
M1M80_18855	COG0489	protein tyrosine kinase activity
M1M80_18860	COG3944	biosynthesis protein
M1M80_18870	COG4715	Zinc finger, swim domain protein
M1M80_18875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M1M80_18880	COG0561	phosphatase activity
M1M80_18885	COG1349	DNA-binding transcription factor activity
M1M80_18890	COG0629	single-stranded DNA binding
M1M80_18905	COG2602	Beta-lactamase
M1M80_18910	COG3764	Sortase (surface protein transpeptidase)
M1M80_18920	COG3279	Response regulator of the LytR AlgR family
M1M80_18930	COG2972	Histidine kinase
M1M80_18930	COG0745	RESPONSE REGULATOR receiver
M1M80_18935	COG1970	mechanosensitive ion channel activity
M1M80_18940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M1M80_18945	COG0457	Tetratricopeptide repeat
M1M80_18950	COG4786	Flagellar basal body rod
M1M80_18955	COG4786	Flagellar basal body rod
M1M80_18960	COG1077	Cell shape determining protein MreB Mrl
M1M80_18965	COG1609	Transcriptional regulator
M1M80_18975	COG1846	Transcriptional regulator
M1M80_18980	COG2814	Major facilitator Superfamily
M1M80_18985	COG3420	alginic acid biosynthetic process
M1M80_18990	COG1953	Uracil, thiamine, allantoin
M1M80_18995	COG0477	Major facilitator Superfamily
M1M80_19000	COG1335	isochorismatase
M1M80_19010	COG0004	ammonium transporteR
M1M80_19015	COG0347	Belongs to the P(II) protein family
M1M80_19020	COG0671	phosphoesterase, PA-phosphatase related
M1M80_19030	COG0739	heme binding
M1M80_19035	COG1247	-acetyltransferase
M1M80_19045	COG1086	Polysaccharide biosynthesis protein
M1M80_19050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1M80_19055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1M80_19060	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
M1M80_19075	COG2089	acid synthase
M1M80_19085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1M80_19090	COG0789	Transcriptional regulator
M1M80_19100	COG2910	NAD(P)H-binding
M1M80_19105	COG1959	2 iron, 2 sulfur cluster binding
M1M80_19110	COG0804	urea catabolic process
M1M80_19115	COG0832	Belongs to the urease beta subunit family
M1M80_19120	COG0831	urea catabolic process
M1M80_19150	COG3237	CsbD-like
M1M80_19155	COG1994	Peptidase M50
M1M80_19160	COG0457	Tetratricopeptide repeat
M1M80_19165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1M80_19170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1M80_19180	COG2304	oxidoreductase activity
M1M80_19185	COG2304	oxidoreductase activity
M1M80_19190	COG2385	sporulation resulting in formation of a cellular spore
M1M80_19195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1M80_19205	COG4836	Membrane
M1M80_19220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M1M80_19225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M1M80_19230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M1M80_19235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M1M80_19240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M1M80_19250	COG0356	it plays a direct role in the translocation of protons across the membrane
M1M80_19260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M1M80_19265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M1M80_19270	COG4475	Protein of unknown function (DUF436)
M1M80_19275	COG0698	ribose 5-phosphate isomerase
M1M80_19280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1M80_19285	COG1971	Probably functions as a manganese efflux pump
M1M80_19290	COG0009	L-threonylcarbamoyladenylate synthase
M1M80_19295	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M1M80_19315	COG2890	protein-(glutamine-N5) methyltransferase activity
M1M80_19320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M1M80_19325	COG0346	lactoylglutathione lyase activity
M1M80_19330	COG0789	Transcriptional regulator
M1M80_19335	COG0679	Auxin Efflux Carrier
M1M80_19340	COG0281	malic enzyme
M1M80_19345	COG1435	thymidine kinase activity
M1M80_19355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M1M80_19365	COG1494	fructose-1,6-bisphosphatase
M1M80_19370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1M80_19375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1M80_19380	COG0191	fructose-bisphosphate aldolase activity
M1M80_19385	COG2204	response regulator
M1M80_19390	COG4821	SIS domain
M1M80_19395	COG0504	CTP synthase activity
M1M80_19400	COG3343	RNA polymerase activity
M1M80_19405	COG1960	acyl-CoA dehydrogenase activity
M1M80_19410	COG0247	lactate metabolic process
M1M80_19410	COG2181	nitrate reductase activity
M1M80_19415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1M80_19420	COG4294	response to UV
M1M80_19430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1M80_19435	COG1132	(ABC) transporter
M1M80_19440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1M80_19450	COG2181	nitrate reductase activity
M1M80_19455	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M1M80_19460	COG1140	nitrate reductase beta subunit
M1M80_19465	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M1M80_19470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1M80_19480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1M80_19485	COG2223	nitrite transmembrane transporter activity
M1M80_19490	COG0018	arginyl-trna synthetase
M1M80_19495	COG4506	Protein conserved in bacteria
M1M80_19510	COG0535	radical SAM domain protein
M1M80_19520	COG1131	(ABC) transporter
M1M80_19530	COG0612	Peptidase, M16
M1M80_19545	COG3391	amine dehydrogenase activity
M1M80_19550	COG3391	amine dehydrogenase activity
M1M80_19555	COG0457	Tetratricopeptide repeat
M1M80_19570	COG0010	Belongs to the arginase family
M1M80_19575	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M1M80_19580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1M80_19590	COG1994	Peptidase M50
M1M80_19595	COG1942	4-Oxalocrotonate Tautomerase
M1M80_19600	COG1846	Transcriptional regulator
M1M80_19605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1M80_19620	COG1959	2 iron, 2 sulfur cluster binding
M1M80_19625	COG3465	dGTPase activity
M1M80_19630	COG1078	dGTPase activity
M1M80_19635	COG4844	belongs to the
M1M80_19645	COG0697	spore germination
M1M80_19655	COG0095	Lipoate-protein ligase
M1M80_19660	COG0583	DNA-binding transcription factor activity
M1M80_19665	COG0280	phosphate acetyltransferase
M1M80_19670	COG3253	May function as heme-dependent peroxidase
M1M80_19675	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_19680	COG0436	Aminotransferase
M1M80_19685	COG2814	Major facilitator Superfamily
M1M80_19690	COG0151	Belongs to the GarS family
M1M80_19695	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_19700	COG1917	Cupin 2, conserved barrel domain protein
M1M80_19705	COG0077	Prephenate dehydratase
M1M80_19710	COG2814	Major facilitator Superfamily
M1M80_19715	COG0833	amino acid
M1M80_19720	COG4187	Peptidase family M20/M25/M40
M1M80_19725	COG1012	belongs to the aldehyde dehydrogenase family
M1M80_19730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1M80_19740	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M1M80_19745	COG1091	dTDP-4-dehydrorhamnose reductase activity
M1M80_19750	COG1088	dTDP-glucose 4,6-dehydratase activity
M1M80_19755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M1M80_19765	COG0456	acetyltransferase
M1M80_19780	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M1M80_19785	COG0463	Glycosyl transferase, family 2
M1M80_19795	COG2363	Small membrane protein
M1M80_19800	COG2233	PERMEase
M1M80_19810	COG1012	belongs to the aldehyde dehydrogenase family
M1M80_19815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M1M80_19820	COG1216	Glycosyl transferase, family 2
M1M80_19825	COG0351	phosphomethylpyrimidine kinase
M1M80_19835	COG1621	beta-fructofuranosidase activity
M1M80_19840	COG1263	PTS System
M1M80_19840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_19845	COG2116	formate transmembrane transporter activity
M1M80_19850	COG3711	transcriptional antiterminator
M1M80_19860	COG1404	Belongs to the peptidase S8 family
M1M80_19865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1M80_19870	COG0778	Nitroreductase
M1M80_19875	COG0772	Belongs to the SEDS family
M1M80_19900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1M80_19905	COG2261	transglycosylase associated protein
M1M80_19910	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M1M80_19915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M1M80_19920	COG2246	polysaccharide biosynthetic process
M1M80_19925	COG1309	transcriptional regulator
M1M80_19935	COG3162	membrane
M1M80_19940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1M80_19945	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1M80_19950	COG2837	iron assimilation
M1M80_19955	COG2822	iron ion transport
M1M80_19960	COG0672	)-iron permease
M1M80_19965	COG0352	thiamine-phosphate diphosphorylase activity
M1M80_19970	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M1M80_19975	COG0583	DNA-binding transcription factor activity
M1M80_19980	COG1380	Effector of murein hydrolase LrgA
M1M80_19985	COG1346	cytolysis
M1M80_19995	COG4895	conserved protein (DUF2196)
M1M80_20000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M1M80_20005	COG0346	lactoylglutathione lyase activity
M1M80_20015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1M80_20020	COG1404	Belongs to the peptidase S8 family
M1M80_20025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_20025	COG1263	PTS System
M1M80_20030	COG3711	transcriptional antiterminator
M1M80_20035	COG1442	glycosyl transferase family 8
M1M80_20040	COG5522	Integral membrane protein (intg_mem_TP0381)
M1M80_20045	COG1846	Transcriptional regulator
M1M80_20055	COG2234	aminopeptidase activity
M1M80_20070	COG2814	Major facilitator Superfamily
M1M80_20075	COG2357	RelA SpoT domain protein
M1M80_20080	COG1575	Belongs to the MenA family. Type 1 subfamily
M1M80_20095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1M80_20100	COG1696	Membrane protein involved in D-alanine export
M1M80_20105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1M80_20110	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M1M80_20115	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
M1M80_20120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1M80_20125	COG1486	melibiose metabolic process
M1M80_20130	COG1447	Phosphotransferase system cellobiose-specific component IIA
M1M80_20135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1M80_20140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M1M80_20145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1M80_20145	COG3711	transcriptional antiterminator
M1M80_20155	COG2094	Belongs to the DNA glycosylase MPG family
M1M80_20160	COG0753	catalase activity
M1M80_20165	COG2814	Major facilitator Superfamily
M1M80_20170	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M1M80_20175	COG1131	(ABC) transporter
M1M80_20195	COG1595	DNA-templated transcription, initiation
M1M80_20200	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1M80_20205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1M80_20210	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M1M80_20215	COG4988	ABC transporter
M1M80_20220	COG1294	oxidase, subunit
M1M80_20225	COG1271	oxidase subunit
M1M80_20230	COG3493	citrate carrier protein
M1M80_20240	COG0726	polysaccharide deacetylase
M1M80_20250	COG3842	ATPase activity
M1M80_20255	COG2508	Transcriptional regulator
M1M80_20260	COG1012	belongs to the aldehyde dehydrogenase family
M1M80_20265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M1M80_20275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1M80_20285	COG4585	Histidine kinase
M1M80_20290	COG2197	response regulator
M1M80_20295	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1M80_20305	COG4894	glucomannan catabolic process
M1M80_20315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M1M80_20320	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_20325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1M80_20330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1M80_20335	COG2610	gluconate transmembrane transporter activity
M1M80_20340	COG0500	methyltransferase
M1M80_20345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1M80_20360	COG0753	catalase activity
M1M80_20360	COG0693	protein deglycase activity
M1M80_20365	COG2851	Citrate transporter
M1M80_20370	COG2273	Hydrolase Family 16
M1M80_20375	COG2723	6-phospho-beta-galactosidase activity
M1M80_20380	COG2190	(PTS) system
M1M80_20380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_20380	COG1263	PTS System
M1M80_20385	COG3711	transcriptional antiterminator
M1M80_20395	COG2270	Major facilitator Superfamily
M1M80_20400	COG0513	Belongs to the DEAD box helicase family
M1M80_20405	COG3401	FG-GAP repeat protein
M1M80_20405	COG2755	lipolytic protein G-D-S-L family
M1M80_20495	COG0697	spore germination
M1M80_20505	COG0861	Integral membrane protein TerC family
M1M80_20510	COG0589	response to stress
M1M80_20515	COG2723	6-phospho-beta-galactosidase activity
M1M80_20520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_20520	COG2190	(PTS) system
M1M80_20520	COG1263	PTS System
M1M80_20555	COG5444	nuclease activity
M1M80_20590	COG3507	Belongs to the glycosyl hydrolase 43 family
M1M80_20605	COG2986	histidine ammonia-lyase
M1M80_20610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M1M80_20615	COG1228	amidohydrolase
M1M80_20620	COG0010	Belongs to the arginase family
M1M80_20625	COG0833	amino acid
M1M80_20630	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M1M80_20635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1M80_20640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M1M80_20645	COG2390	Transcriptional regulator
M1M80_20655	COG3192	ethanolamine utilization protein
M1M80_20660	COG2079	MmgE PrpD family protein
M1M80_20665	COG1473	amidohydrolase
M1M80_20670	COG1126	abc transporter atp-binding protein
M1M80_20675	COG0765	amino acid transport
M1M80_20680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1M80_20685	COG0456	acetyltransferase
M1M80_20690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1M80_20695	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M1M80_20700	COG0561	phosphatase activity
M1M80_20730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1M80_20735	COG5294	Protein conserved in bacteria
M1M80_20740	COG0577	efflux transmembrane transporter activity
M1M80_20745	COG1136	(ABC) transporter
M1M80_20750	COG2205	protein histidine kinase activity
M1M80_20755	COG0745	RESPONSE REGULATOR receiver
M1M80_20760	COG0191	fructose-bisphosphate aldolase activity
M1M80_20765	COG1082	Xylose isomerase domain protein TIM barrel
M1M80_20770	COG1082	Xylose isomerase domain protein TIM barrel
M1M80_20775	COG0673	inositol 2-dehydrogenase activity
M1M80_20780	COG2814	Major facilitator Superfamily
M1M80_20785	COG1082	Xylose isomerase domain protein TIM barrel
M1M80_20790	COG3962	Belongs to the TPP enzyme family
M1M80_20795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1M80_20805	COG1012	belongs to the aldehyde dehydrogenase family
M1M80_20810	COG1349	DNA-binding transcription factor activity
M1M80_20815	COG0667	Aldo Keto reductase
M1M80_20830	COG2271	Major facilitator Superfamily
M1M80_20850	COG2814	Major facilitator Superfamily
M1M80_20855	COG0326	Molecular chaperone. Has ATPase activity
M1M80_20865	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_20870	COG1309	transcriptional regulator
M1M80_20875	COG1012	belongs to the aldehyde dehydrogenase family
M1M80_20885	COG0667	Aldo Keto reductase
M1M80_20890	COG0789	Transcriptional regulator
M1M80_20895	COG1714	RDD family
M1M80_20900	COG2311	Membrane
M1M80_20905	COG1917	Cupin 2, conserved barrel domain protein
M1M80_20910	COG1309	transcriptional regulator
M1M80_20915	COG1028	Short-chain dehydrogenase reductase Sdr
M1M80_20920	COG1846	Transcriptional regulator
M1M80_20925	COG1380	Effector of murein hydrolase LrgA
M1M80_20930	COG1346	cytolysis
M1M80_20950	COG5039	Polysaccharide pyruvyl transferase
M1M80_20955	COG1929	Belongs to the glycerate kinase type-1 family
M1M80_20960	COG1802	Transcriptional regulator
M1M80_20965	COG1070	Carbohydrate kinase
M1M80_20970	COG2610	gluconate transmembrane transporter activity
M1M80_20975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M1M80_20980	COG0450	alkyl hydroperoxide reductase
M1M80_20985	COG3634	alkyl hydroperoxide reductase activity
M1M80_20995	COG2723	6-phospho-beta-galactosidase activity
M1M80_21000	COG2190	(PTS) system
M1M80_21000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1M80_21000	COG1263	PTS System
M1M80_21005	COG2188	Transcriptional regulator
M1M80_21010	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
M1M80_21025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M1M80_21040	COG1063	alcohol dehydrogenase
M1M80_21060	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
M1M80_21065	COG0456	acetyltransferase
M1M80_21070	COG0457	Tetratricopeptide repeat
M1M80_21080	COG0010	Belongs to the arginase family
M1M80_21085	COG0833	amino acid
M1M80_21090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1M80_21095	COG3829	transcription factor binding
M1M80_21100	COG5002	protein histidine kinase activity
M1M80_21105	COG0745	RESPONSE REGULATOR receiver
M1M80_21125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1M80_21130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M1M80_21135	COG4853	Protein conserved in bacteria
M1M80_21140	COG4863	YycH protein
M1M80_21145	COG5002	protein histidine kinase activity
M1M80_21150	COG0745	RESPONSE REGULATOR receiver
M1M80_21180	COG0346	lactoylglutathione lyase activity
M1M80_21185	COG0305	Participates in initiation and elongation during chromosome replication
M1M80_21200	COG3093	addiction module antidote protein HigA
M1M80_21205	COG2807	transmembrane transport
M1M80_21210	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M1M80_21215	COG0359	binds to the 23S rRNA
M1M80_21220	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M1M80_21225	COG4241	membrane
M1M80_21235	COG5577	PFAM Coat F domain
M1M80_21240	COG1733	regulation of RNA biosynthetic process
M1M80_21245	COG1227	inorganic diphosphatase activity
M1M80_21255	COG2271	Major facilitator Superfamily
M1M80_21265	COG4319	ketosteroid isomerase
M1M80_21270	COG1357	PFAM Pentapeptide repeats (8 copies)
M1M80_21275	COG2814	Major facilitator Superfamily
M1M80_21280	COG0583	DNA-binding transcription factor activity
M1M80_21285	COG2153	protein acetylation
M1M80_21295	COG0583	DNA-binding transcription factor activity
M1M80_21315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1M80_21320	COG1733	regulation of RNA biosynthetic process
M1M80_21325	COG1846	Transcriptional regulator
M1M80_21330	COG2153	protein acetylation
M1M80_21335	COG2364	Membrane
M1M80_21345	COG1331	Highly conserved protein containing a thioredoxin domain
M1M80_21355	COG2315	Protein conserved in bacteria
M1M80_21365	COG0789	Transcriptional regulator
M1M80_21385	COG2856	Zn peptidase
M1M80_21395	COG1331	Highly conserved protein containing a thioredoxin domain
M1M80_21400	COG1266	CAAX protease self-immunity
M1M80_21405	COG0477	Major facilitator Superfamily
M1M80_21405	COG2814	Major facilitator Superfamily
M1M80_21410	COG0346	lactoylglutathione lyase activity
M1M80_21415	COG1609	Transcriptional regulator
M1M80_21420	COG0708	Exodeoxyribonuclease III
M1M80_21425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M1M80_21430	COG0629	single-stranded DNA binding
M1M80_21435	COG0360	Binds together with S18 to 16S ribosomal RNA
M1M80_21440	COG0012	GTP binding
M1M80_21445	COG0243	molybdopterin cofactor binding
M1M80_21450	COG4481	Protein conserved in bacteria
M1M80_21455	COG3949	Membrane
M1M80_21465	COG1475	DNA binding
M1M80_21470	COG1192	Involved in chromosome partitioning
M1M80_21480	COG1475	DNA binding
M1M80_21485	COG0357	Ribosomal RNA small subunit methyltransferase G
M1M80_21490	COG0445	tRNA wobble uridine modification
M1M80_21495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M1M80_21500	COG1847	R3H domain protein
M1M80_21505	COG0706	membrane insertase activity
M1M80_21510	COG0594	ribonuclease P activity