locus-tag	class	description
N288_00010	COG0592	DNA-directed DNA polymerase activity
N288_00020	COG2501	S4 domain
N288_00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N288_00035	COG0187	DNA topoisomerase II activity
N288_00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N288_00080	COG0516	GMP reductase activity
N288_00080	COG0517	IMP dehydrogenase activity
N288_00090	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
N288_00095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
N288_00115	COG1428	Deoxynucleoside kinase
N288_00120	COG1428	Deoxynucleoside kinase
N288_00125	COG3858	chitin binding
N288_00125	COG1388	LysM domain
N288_00130	COG1335	isochorismatase
N288_00135	COG0590	tRNA wobble adenosine to inosine editing
N288_00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N288_00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N288_00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N288_00200	COG1982	Orn Lys Arg decarboxylase major
N288_00205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N288_00210	COG3870	Protein conserved in bacteria
N288_00215	COG1728	Protein conserved in bacteria
N288_00220	COG0470	DNA polymerase III
N288_00225	COG1774	PSP1 C-terminal conserved region
N288_00230	COG4467	Involved in initiation control of chromosome replication
N288_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N288_00240	COG2827	Endonuclease containing a URI domain
N288_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N288_00250	COG2002	toxin-antitoxin pair type II binding
N288_00260	COG0084	hydrolase, TatD family'
N288_00270	COG3583	domain protein
N288_00270	COG3584	3D domain protein
N288_00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N288_00295	COG4466	Protein conserved in bacteria
N288_00310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N288_00315	COG0251	oxidation-reduction process
N288_00330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N288_00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N288_00340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N288_00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N288_00360	COG2002	toxin-antitoxin pair type II binding
N288_00365	COG2244	polysaccharide biosynthetic process
N288_00370	COG3956	TIGRFAM MazG family protein
N288_00375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N288_00395	COG1098	S1 RNA binding domain
N288_00410	COG2208	phosphoserine phosphatase activity
N288_00415	COG2304	oxidoreductase activity
N288_00420	COG0515	serine threonine protein kinase
N288_00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N288_00440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
N288_00445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N288_00450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N288_00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N288_00460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N288_00465	COG0512	Glutamine amidotransferase of anthranilate synthase
N288_00470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N288_00475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N288_00480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N288_00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N288_00490	COG1396	sequence-specific DNA binding
N288_00495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N288_00590	COG3880	PFAM UvrB UvrC protein
N288_00595	COG3869	Catalyzes the specific phosphorylation of arginine residues in
N288_00600	COG0542	response to heat
N288_00605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N288_00615	COG4956	integral membrane protein (PIN domain superfamily)
N288_00625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N288_00630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N288_00635	COG1045	serine acetyltransferase
N288_00640	COG0215	cysteine-tRNA ligase activity
N288_00650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N288_00655	COG3688	RNA-binding protein containing a PIN domain
N288_00670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N288_00675	COG0250	Participates in transcription elongation, termination and antitermination
N288_00680	COG0081	regulation of translation
N288_00685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N288_00690	COG0222	ribosome binding
N288_00695	COG2813	Specifically methylates the guanine in position
N288_00705	COG0085	RNA polymerase activity
N288_00710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N288_00715	COG1358	cellular component organization or biogenesis
N288_00720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N288_00735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N288_00740	COG0051	transcription antitermination factor activity, RNA binding
N288_00745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N288_00750	COG0088	Forms part of the polypeptide exit tunnel
N288_00760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N288_00765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N288_00770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N288_00775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N288_00780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N288_00785	COG0255	Belongs to the universal ribosomal protein uL29 family
N288_00790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N288_00800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N288_00810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N288_00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N288_00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N288_00830	COG1841	ribosomal large subunit assembly
N288_00835	COG0200	Binds to the 23S rRNA
N288_00840	COG0201	protein transport
N288_00845	COG0563	adenylate kinase activity
N288_00850	COG0024	Methionine aminopeptidase
N288_00855	COG2163	COG2163 Ribosomal protein L14E L6E L27E
N288_00860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N288_00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N288_00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N288_00880	COG0202	RNA polymerase activity
N288_00885	COG0203	ribosomal protein L17
N288_00895	COG1122	ATPase activity
N288_00900	COG1122	ATPase activity
N288_00905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N288_00910	COG0101	tRNA pseudouridine synthase activity
N288_00915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N288_00920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N288_00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
N288_00940	COG0489	protein tyrosine kinase activity
N288_00950	COG2194	sulfuric ester hydrolase activity
N288_00955	COG0726	polysaccharide deacetylase
N288_01040	COG1595	DNA-templated transcription, initiation
N288_01045	COG5662	AntiSigma factor
N288_01050	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
N288_01055	COG4856	YbbR-like protein
N288_01060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N288_01065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N288_01110	COG5566	PFAM Mor transcription activator
N288_01120	COG2323	membrane
N288_01125	COG0406	alpha-ribazole phosphatase activity
N288_01135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N288_01140	COG1968	undecaprenyl-diphosphatase activity
N288_01145	COG1301	dicarboxylic acid transport
N288_01155	COG0582	viral genome integration into host DNA
N288_01165	COG2706	6-phosphogluconolactonase activity
N288_01175	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_01190	COG3403	YqcI/YcgG family
N288_01195	COG0668	transmembrane transport
N288_01200	COG1595	DNA-templated transcription, initiation
N288_01210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N288_01215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N288_01220	COG1597	lipid kinase activity
N288_01230	COG0783	Belongs to the Dps family
N288_01235	COG1238	metal cluster binding
N288_01245	COG1695	Transcriptional regulator
N288_01250	COG0730	response to heat
N288_01255	COG0018	arginyl-trna synthetase
N288_01260	COG0772	Belongs to the SEDS family
N288_01275	COG2814	Major facilitator Superfamily
N288_01280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N288_01285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N288_01290	COG1120	ATPase activity
N288_01295	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
N288_01305	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
N288_01310	COG1492	cobalamin metabolic process
N288_01315	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N288_01325	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
N288_01330	COG2096	Adenosyltransferase
N288_01370	COG2076	Multidrug Resistance protein
N288_01395	COG0395	ABC-type sugar transport system, permease component
N288_01400	COG0346	lactoylglutathione lyase activity
N288_01410	COG0659	secondary active sulfate transmembrane transporter activity
N288_01415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N288_01430	COG1181	Belongs to the D-alanine--D-alanine ligase family
N288_01435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N288_01445	COG1595	DNA-templated transcription, initiation
N288_01475	COG0513	Belongs to the DEAD box helicase family
N288_01480	COG4294	response to UV
N288_01485	COG3402	PFAM membrane-flanked domain
N288_01490	COG3428	Bacterial PH domain
N288_01495	COG0705	Rhomboid family
N288_01505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N288_01515	COG0864	Transcriptional regulator
N288_01520	COG2337	Toxic component of a toxin-antitoxin (TA) module
N288_01525	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_01530	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_01535	COG2172	sigma factor antagonist activity
N288_01540	COG2208	phosphoserine phosphatase activity
N288_01545	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_01550	COG2172	sigma factor antagonist activity
N288_01555	COG1191	sigma factor activity
N288_01560	COG2208	phosphoserine phosphatase activity
N288_01565	COG2183	response to ionizing radiation
N288_01575	COG3091	SprT-like family
N288_01650	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
N288_01660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N288_01665	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N288_01670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N288_01675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N288_01680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N288_01685	COG0047	phosphoribosylformylglycinamidine synthase activity
N288_01690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N288_01695	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N288_01700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N288_01705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N288_01715	COG0151	Belongs to the GarS family
N288_01730	COG1470	cell adhesion involved in biofilm formation
N288_01735	COG4496	protein, YerC YecD
N288_01745	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
N288_01750	COG0210	DNA helicase
N288_01755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N288_01760	COG4851	CamS sex pheromone cAM373 precursor
N288_01770	COG1012	belongs to the aldehyde dehydrogenase family
N288_01780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N288_01785	COG2224	Isocitrate lyase
N288_01790	COG5506	Protein of unknown function (DUF1694)
N288_01805	COG2720	vancomycin resistance protein
N288_01815	COG2814	Major facilitator Superfamily
N288_01820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N288_01825	COG0154	amidase activity
N288_01850	COG1301	dicarboxylic acid transport
N288_01855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N288_01865	COG0681	Belongs to the peptidase S26 family
N288_01870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N288_01890	COG1522	sequence-specific DNA binding
N288_01900	COG1335	isochorismatase
N288_01905	COG1595	DNA-templated transcription, initiation
N288_01930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N288_01950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N288_01955	COG1309	transcriptional regulator
N288_01965	COG1597	lipid kinase activity
N288_01980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N288_01985	COG2066	Belongs to the glutaminase family
N288_01995	COG2814	Major facilitator Superfamily
N288_02000	COG0778	Nitroreductase
N288_02005	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
N288_02010	COG1280	lysine exporter protein (LysE YggA)
N288_02015	COG0166	Belongs to the GPI family
N288_02055	COG1595	DNA-templated transcription, initiation
N288_02075	COG1595	DNA-templated transcription, initiation
N288_02085	COG2814	Major facilitator Superfamily
N288_02090	COG1846	Transcriptional regulator
N288_02095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N288_02100	COG2169	Transcriptional regulator
N288_02100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N288_02105	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
N288_02110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N288_02125	COG1609	Transcriptional regulator
N288_02135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N288_02140	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
N288_02165	COG2130	NADP-dependent
N288_02170	COG2207	Transcriptional regulator
N288_02170	COG4753	response regulator
N288_02175	COG2972	Histidine kinase
N288_02195	COG3250	beta-galactosidase activity
N288_02210	COG2186	Transcriptional regulator
N288_02215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N288_02220	COG0385	Bile acid
N288_02225	COG0501	Belongs to the peptidase M48B family
N288_02235	COG2814	Major facilitator Superfamily
N288_02250	COG1131	(ABC) transporter
N288_02265	COG1595	DNA-templated transcription, initiation
N288_02280	COG2321	neutral zinc metallopeptidase
N288_02285	COG4297	protein containing double-stranded beta helix domain
N288_02295	COG0110	maltose O-acetyltransferase activity
N288_02320	COG5002	protein histidine kinase activity
N288_02350	COG1842	Phage shock protein A
N288_02355	COG1012	belongs to the aldehyde dehydrogenase family
N288_02385	COG0494	nUDIX hydrolase
N288_02400	COG1764	response to oxidative stress
N288_02405	COG1846	Transcriptional regulator
N288_02465	COG3813	Protein conserved in bacteria
N288_02485	COG0039	L-malate dehydrogenase activity
N288_02505	COG1247	-acetyltransferase
N288_02530	COG2199	diguanylate cyclase activity
N288_02540	COG2124	cytochrome p450
N288_02555	COG3344	reverse transcriptase
N288_02560	COG1704	LemA family
N288_02590	COG1966	Carbon starvation protein
N288_02600	COG0546	phosphoglycolate phosphatase activity
N288_02625	COG5434	Belongs to the glycosyl hydrolase 28 family
N288_02630	COG2078	PFAM AMMECR1 domain protein
N288_02630	COG3885	ferrous iron binding
N288_02635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N288_02640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N288_02655	COG0217	transcriptional regulatory protein
N288_02665	COG0346	lactoylglutathione lyase activity
N288_02685	COG0598	Magnesium transport protein CorA
N288_02695	COG3300	MHYT domain
N288_02695	COG5001	Diguanylate cyclase
N288_02700	COG0789	Transcriptional regulator
N288_02705	COG1733	regulation of RNA biosynthetic process
N288_02710	COG2814	Major facilitator Superfamily
N288_02715	COG0656	L-ascorbic acid biosynthetic process
N288_02720	COG2304	oxidoreductase activity
N288_02725	COG0386	Belongs to the glutathione peroxidase family
N288_02740	COG3104	oligopeptide transport
N288_02745	COG0778	Nitroreductase
N288_02760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N288_02795	COG2814	Major facilitator Superfamily
N288_02800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N288_02805	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
N288_02810	COG1160	GTP binding
N288_02815	COG4682	membrane
N288_02820	COG1131	(ABC) transporter
N288_02825	COG0842	Transport permease protein
N288_02830	COG4585	Histidine kinase
N288_02835	COG2197	response regulator
N288_02845	COG0527	aspartate kinase activity
N288_02865	COG1562	ergosterol biosynthetic process
N288_02905	COG1028	Short-chain dehydrogenase reductase Sdr
N288_02925	COG0725	ABC transporter, periplasmic molybdate-binding protein
N288_02930	COG1388	LysM domain
N288_02940	COG1476	TRANSCRIPTIONal
N288_02950	COG1131	(ABC) transporter
N288_02975	COG1595	DNA-templated transcription, initiation
N288_02985	COG0406	alpha-ribazole phosphatase activity
N288_03005	COG1131	(ABC) transporter
N288_03010	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
N288_03025	COG2318	DinB family
N288_03030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N288_03045	COG2205	protein histidine kinase activity
N288_03050	COG0745	RESPONSE REGULATOR receiver
N288_03055	COG2311	Membrane
N288_03060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
N288_03070	COG1073	alpha beta
N288_03070	COG2226	methyltransferase
N288_03075	COG0025	NhaP-type Na H and K H
N288_03080	COG2966	Psort location CytoplasmicMembrane, score
N288_03085	COG3610	response to peptide
N288_03090	COG1132	(ABC) transporter
N288_03095	COG1132	(ABC) transporter
N288_03100	COG1115	amino acid carrier protein
N288_03115	COG0697	spore germination
N288_03120	COG1522	sequence-specific DNA binding
N288_03125	COG0352	thiamine-phosphate diphosphorylase activity
N288_03130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N288_03140	COG2022	thiamine diphosphate biosynthetic process
N288_03145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N288_03165	COG1063	alcohol dehydrogenase
N288_03180	COG0154	amidase activity
N288_03195	COG1695	Transcriptional regulator
N288_03225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N288_03225	COG0723	plastoquinol--plastocyanin reductase activity
N288_03235	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N288_03240	COG0697	spore germination
N288_03265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N288_03275	COG1657	PFAM Prenyltransferase squalene oxidase
N288_03280	COG1994	Peptidase M50
N288_03305	COG2197	response regulator
N288_03330	COG0488	(ABC) transporter
N288_03335	COG3546	catalase activity
N288_03355	COG2244	polysaccharide biosynthetic process
N288_03380	COG0598	Magnesium transport protein CorA
N288_03385	COG0300	oxidoreductase activity
N288_03390	COG1309	transcriptional regulator
N288_03395	COG1607	acyl-coa hydrolase
N288_03410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N288_03420	COG0805	protein transport
N288_03425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N288_03485	COG0670	Belongs to the BI1 family
N288_03490	COG1970	mechanosensitive ion channel activity
N288_03500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N288_03505	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N288_03515	COG4145	pantothenate transmembrane transporter activity
N288_03520	COG1254	Belongs to the acylphosphatase family
N288_03530	COG2309	aminopeptidase activity
N288_03560	COG1183	phosphatidylcholine synthase activity
N288_03565	COG2986	histidine ammonia-lyase
N288_03575	COG0450	alkyl hydroperoxide reductase
N288_03580	COG0450	alkyl hydroperoxide reductase
N288_03585	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N288_03595	COG2323	membrane
N288_03600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N288_03605	COG1360	Flagellar Motor Protein
N288_03610	COG2211	Major facilitator Superfamily
N288_03620	COG2814	Major facilitator Superfamily
N288_03630	COG1115	amino acid carrier protein
N288_03635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N288_03635	COG1522	sequence-specific DNA binding
N288_03640	COG2313	pseudouridylate synthase activity
N288_03645	COG3764	Sortase (surface protein transpeptidase)
N288_03650	COG1396	sequence-specific DNA binding
N288_03655	COG0681	Belongs to the peptidase S26 family
N288_03695	COG0318	PFAM AMP-dependent synthetase and ligase
N288_03700	COG1960	acyl-CoA dehydrogenase activity
N288_03710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N288_03715	COG4106	trans-aconitate 2-methyltransferase activity
N288_03725	COG2188	Transcriptional regulator
N288_03730	COG3486	L-lysine 6-monooxygenase (NADPH) activity
N288_03735	COG0693	protein deglycase activity
N288_03745	COG0024	Methionine aminopeptidase
N288_03750	COG2226	methyltransferase
N288_03760	COG4840	Belongs to the UPF0435 family
N288_03765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N288_03775	COG1295	ribonuclease BN
N288_03790	COG2217	Heavy metal translocating P-type atpase
N288_03795	COG0477	Major facilitator Superfamily
N288_03805	COG3871	stress protein (general stress protein 26)
N288_03810	COG0387	Pfam Sodium calcium exchanger
N288_03815	COG2364	Membrane
N288_03825	COG0346	lactoylglutathione lyase activity
N288_03880	COG0535	radical SAM domain protein
N288_03890	COG0405	Gamma-glutamyltransferase
N288_03895	COG2323	membrane
N288_03915	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
N288_03920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N288_03950	COG1129	ABC transporter
N288_03955	COG4211	Belongs to the binding-protein-dependent transport system permease family
N288_03965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N288_03985	COG0488	(ABC) transporter
N288_04110	COG0305	Participates in initiation and elongation during chromosome replication
N288_04140	COG0745	RESPONSE REGULATOR receiver
N288_04155	COG2205	protein histidine kinase activity
N288_04215	COG0640	Transcriptional regulator
N288_04220	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N288_04225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N288_04230	COG0492	ferredoxin-NADP+ reductase activity
N288_04250	COG5002	protein histidine kinase activity
N288_04275	COG5505	Protein of unknown function (DUF819)
N288_04285	COG1012	belongs to the aldehyde dehydrogenase family
N288_04300	COG0693	protein deglycase activity
N288_04340	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N288_04345	COG4605	iron ion homeostasis
N288_04350	COG4604	ABC transporter, ATP-binding protein
N288_04355	COG4607	ABC-type enterochelin transport system periplasmic component
N288_04365	COG2329	Antibiotic biosynthesis monooxygenase
N288_04370	COG2203	Gaf domain
N288_04370	COG2199	diguanylate cyclase activity
N288_04410	COG0514	ATP-dependent DNA helicase (RecQ)
N288_04425	COG0494	nUDIX hydrolase
N288_04450	COG2508	Transcriptional regulator
N288_04455	COG1228	amidohydrolase
N288_04460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N288_04465	COG0006	proline dipeptidase activity
N288_04530	COG2207	Transcriptional regulator
N288_04535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N288_04565	COG3443	Belongs to the bacterial solute-binding protein 9 family
N288_04570	COG0861	Integral membrane protein TerC family
N288_04625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N288_04650	COG0656	L-ascorbic acid biosynthetic process
N288_04660	COG0300	oxidoreductase activity
N288_04695	COG1595	DNA-templated transcription, initiation
N288_04700	COG0860	N-Acetylmuramoyl-L-alanine amidase
N288_04710	COG0840	transmembrane signaling receptor activity
N288_04715	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
N288_04730	COG0069	glutamate synthase activity
N288_04735	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
N288_04800	COG1278	Cold shock
N288_04805	COG3239	Fatty acid desaturase
N288_04830	COG0596	Alpha beta hydrolase
N288_04850	COG5002	protein histidine kinase activity
N288_04855	COG0745	RESPONSE REGULATOR receiver
N288_04870	COG3507	Belongs to the glycosyl hydrolase 43 family
N288_04875	COG1940	carbohydrate kinase activity
N288_04885	COG1175	transmembrane transport
N288_04890	COG0395	ABC-type sugar transport system, permease component
N288_04895	COG5578	integral membrane protein
N288_04900	COG2115	Belongs to the xylose isomerase family
N288_04905	COG1070	Carbohydrate kinase
N288_04910	COG0667	Aldo Keto reductase
N288_04915	COG0477	Major facilitator Superfamily
N288_04915	COG2814	Major facilitator Superfamily
N288_04920	COG0730	response to heat
N288_04925	COG3290	protein histidine kinase activity
N288_04930	COG4565	transcriptional regulatory protein
N288_04935	COG3493	citrate carrier protein
N288_04940	COG0281	malic enzyme
N288_04945	COG3173	Aminoglycoside phosphotransferase
N288_04960	COG3706	GGDEF domain
N288_04995	COG1126	abc transporter atp-binding protein
N288_05000	COG0765	amino acid transport
N288_05005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N288_05015	COG3173	Aminoglycoside phosphotransferase
N288_05030	COG0488	(ABC) transporter
N288_05035	COG4807	Protein conserved in bacteria
N288_05050	COG1024	Enoyl-CoA hydratase
N288_05050	COG1250	3-hydroxyacyl-CoA dehydrogenase
N288_05060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N288_05065	COG2272	Belongs to the type-B carboxylesterase lipase family
N288_05070	COG3835	regulator
N288_05075	COG2610	gluconate transmembrane transporter activity
N288_05080	COG1929	Belongs to the glycerate kinase type-1 family
N288_05085	COG2172	sigma factor antagonist activity
N288_05110	COG3459	Glycosyltransferase 36 associated
N288_05120	COG1653	transport
N288_05125	COG1175	transmembrane transport
N288_05130	COG0395	ABC-type sugar transport system, permease component
N288_05140	COG1609	Transcriptional regulator
N288_05145	COG1757	Na H antiporter
N288_05165	COG2723	6-phospho-beta-galactosidase activity
N288_05175	COG0142	geranyltranstransferase activity
N288_05185	COG0861	Integral membrane protein TerC family
N288_05190	COG0300	oxidoreductase activity
N288_05205	COG1473	amidohydrolase
N288_05210	COG0456	acetyltransferase
N288_05215	COG0435	Glutathione S-transferase
N288_05245	COG2207	Transcriptional regulator
N288_05260	COG0243	molybdopterin cofactor binding
N288_05265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N288_05305	COG2186	Transcriptional regulator
N288_05310	COG1620	l-lactate permease
N288_05315	COG0247	lactate metabolic process
N288_05320	COG1139	Iron-sulfur cluster binding protein
N288_05325	COG1556	Lactate utilization protein
N288_05345	COG1073	alpha beta
N288_05350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N288_05350	COG1263	PTS System
N288_05350	COG2190	(PTS) system
N288_05370	COG1566	PFAM secretion protein HlyD family protein
N288_05375	COG0655	NAD(P)H dehydrogenase (quinone) activity
N288_05385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N288_05390	COG0765	amino acid transport
N288_05395	COG1126	abc transporter atp-binding protein
N288_05420	COG1757	Na H antiporter
N288_05425	COG3832	glyoxalase III activity
N288_05480	COG0861	Integral membrane protein TerC family
N288_05490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N288_05495	COG1522	sequence-specific DNA binding
N288_05505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N288_05510	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
N288_05515	COG2182	Extracellular solute-binding protein
N288_05525	COG3842	ATPase activity
N288_05530	COG1175	transmembrane transport
N288_05535	COG0395	ABC-type sugar transport system, permease component
N288_05540	COG0584	glycerophosphoryl diester phosphodiesterase
N288_05545	COG0463	Glycosyl transferase, family 2
N288_05555	COG4485	Bacterial membrane protein, YfhO
N288_05570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N288_05575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N288_05590	COG1695	Transcriptional regulator
N288_05610	COG1090	epimerase
N288_05620	COG1028	Short-chain dehydrogenase reductase Sdr
N288_05645	COG1988	membrane-bound metal-dependent
N288_05655	COG1194	a g-specific adenine glycosylase
N288_05665	COG1028	Short-chain dehydrogenase reductase Sdr
N288_05685	COG1132	(ABC) transporter
N288_05695	COG0444	Belongs to the ABC transporter superfamily
N288_05700	COG4608	Belongs to the ABC transporter superfamily
N288_05705	COG0747	negative chemotaxis
N288_05720	COG4129	membrane
N288_05725	COG0067	glutamate synthase
N288_05725	COG0069	glutamate synthase activity
N288_05725	COG0070	glutamate synthase
N288_05730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N288_05735	COG4555	ABC transporter
N288_05760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N288_05770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N288_05780	COG0735	belongs to the Fur family
N288_05910	COG2972	Histidine kinase
N288_05915	COG4753	response regulator
N288_05915	COG2207	Transcriptional regulator
N288_05925	COG0673	inositol 2-dehydrogenase activity
N288_05930	COG0673	inositol 2-dehydrogenase activity
N288_05935	COG3382	B3 4 domain protein
N288_05940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N288_05950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N288_05955	COG0778	Nitroreductase
N288_05965	COG2766	serine protein kinase
N288_05980	COG2718	Belongs to the UPF0229 family
N288_05995	COG2310	stress, protein
N288_06005	COG0656	L-ascorbic acid biosynthetic process
N288_06030	COG2094	Belongs to the DNA glycosylase MPG family
N288_06035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N288_06050	COG3706	GGDEF domain
N288_06050	COG0745	RESPONSE REGULATOR receiver
N288_06070	COG0745	RESPONSE REGULATOR receiver
N288_06075	COG5002	protein histidine kinase activity
N288_06080	COG1823	symporter activity
N288_06085	COG2226	methyltransferase
N288_06090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N288_06100	COG2252	PERMEase
N288_06105	COG4187	Peptidase family M20/M25/M40
N288_06115	COG0745	RESPONSE REGULATOR receiver
N288_06120	COG2205	protein histidine kinase activity
N288_06135	COG1609	Transcriptional regulator
N288_06145	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
N288_06150	COG1737	Transcriptional regulator
N288_06155	COG2610	gluconate transmembrane transporter activity
N288_06165	COG1070	Carbohydrate kinase
N288_06170	COG0306	phosphate transporter
N288_06175	COG1392	Phosphate transport regulator
N288_06180	COG3973	AAA domain
N288_06190	COG2261	transglycosylase associated protein
N288_06195	COG0564	pseudouridine synthase activity
N288_06205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N288_06210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N288_06220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N288_06220	COG3153	acetyltransferase
N288_06225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N288_06230	COG4585	Histidine kinase
N288_06230	COG2203	Gaf domain
N288_06235	COG2197	response regulator
N288_06240	COG0431	NADPH-dependent FMN reductase
N288_06260	COG2719	SpoVR family
N288_06315	COG3118	belongs to the thioredoxin family
N288_06315	COG0492	ferredoxin-NADP+ reductase activity
N288_06335	COG1309	transcriptional regulator
N288_06340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N288_06350	COG1695	Transcriptional regulator
N288_06360	COG2112	serine threonine protein kinase
N288_06385	COG3290	protein histidine kinase activity
N288_06390	COG3279	Response regulator of the LytR AlgR family
N288_06395	COG4555	ABC transporter
N288_06400	COG1668	transmembrane transport
N288_06405	COG2814	Major facilitator Superfamily
N288_06410	COG4412	M6 family metalloprotease domain protein
N288_06410	COG3291	Pkd domain containing protein
N288_06415	COG1295	ribonuclease BN
N288_06420	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
N288_06425	COG2252	PERMEase
N288_06430	COG0778	Nitroreductase
N288_06450	COG0745	RESPONSE REGULATOR receiver
N288_06455	COG5002	protein histidine kinase activity
N288_06455	COG3850	Histidine kinase
N288_06465	COG1253	flavin adenine dinucleotide binding
N288_06485	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_06490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N288_06505	COG0589	response to stress
N288_06510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N288_06520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N288_06525	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N288_06525	COG2213	PTS system mannitol-specific
N288_06530	COG3711	transcriptional antiterminator
N288_06535	COG0246	Mannitol dehydrogenase
N288_06540	COG2814	Major facilitator Superfamily
N288_06545	COG0662	Cupin 2, conserved barrel domain protein
N288_06555	COG0546	phosphoglycolate phosphatase activity
N288_06570	COG1595	DNA-templated transcription, initiation
N288_06590	COG0393	Putative heavy-metal-binding
N288_06595	COG1132	(ABC) transporter
N288_06600	COG1132	(ABC) transporter
N288_06610	COG0114	fumarate hydratase activity
N288_06625	COG3842	ATPase activity
N288_06630	COG2508	Transcriptional regulator
N288_06635	COG1937	Protein conserved in bacteria
N288_06650	COG0189	ligase activity
N288_06655	COG0189	ligase activity
N288_06660	COG0189	ligase activity
N288_06665	COG0189	ligase activity
N288_06670	COG4399	Belongs to the UPF0754 family
N288_06695	COG1090	epimerase
N288_06700	COG0561	phosphatase activity
N288_06705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N288_06715	COG0318	PFAM AMP-dependent synthetase and ligase
N288_06720	COG1024	Enoyl-CoA hydratase
N288_06730	COG4152	abc transporter atp-binding protein
N288_06735	COG1668	transmembrane transport
N288_06740	COG1280	lysine exporter protein (LysE YggA)
N288_06765	COG0420	3'-5' exonuclease activity
N288_06770	COG4717	serine-type aminopeptidase activity
N288_06780	COG3481	metal-dependent phosphohydrolase, HD sub domain
N288_06795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N288_06830	COG1846	Transcriptional regulator
N288_06850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N288_06855	COG0537	adenosine 5'-monophosphoramidase activity
N288_06865	COG1131	(ABC) transporter
N288_06870	COG4473	ABC transporter
N288_06880	COG1473	amidohydrolase
N288_06885	COG0671	phosphoesterase, PA-phosphatase related
N288_06910	COG4191	Histidine kinase
N288_06920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N288_06925	COG2720	vancomycin resistance protein
N288_06935	COG2304	oxidoreductase activity
N288_06940	COG2861	carbohydrate metabolic process
N288_06955	COG4895	conserved protein (DUF2196)
N288_06960	COG3069	C4-dicarboxylate transmembrane transporter activity
N288_06975	COG4585	Histidine kinase
N288_06980	COG2197	response regulator
N288_06990	COG2329	Antibiotic biosynthesis monooxygenase
N288_07000	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N288_07010	COG1309	transcriptional regulator
N288_07015	COG1511	domain protein
N288_07025	COG1234	tRNA 3'-trailer cleavage
N288_07030	COG0095	Lipoate-protein ligase
N288_07035	COG0318	PFAM AMP-dependent synthetase and ligase
N288_07045	COG1024	Enoyl-CoA hydratase
N288_07055	COG4120	Belongs to the binding-protein-dependent transport system permease family
N288_07060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N288_07065	COG1396	sequence-specific DNA binding
N288_07070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N288_07080	COG0501	Belongs to the peptidase M48B family
N288_07095	COG4903	ComK protein
N288_07105	COG0823	Involved in the tonB-independent uptake of proteins
N288_07105	COG1506	peptidase
N288_07105	COG4946	Tricorn protease homolog
N288_07110	COG1316	TRANSCRIPTIONal
N288_07115	COG0398	Pfam SNARE associated Golgi protein
N288_07145	COG0411	ABC transporter
N288_07155	COG0559	Belongs to the binding-protein-dependent transport system permease family
N288_07170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N288_07180	COG1028	Short-chain dehydrogenase reductase Sdr
N288_07185	COG0183	Belongs to the thiolase family
N288_07190	COG1335	isochorismatase
N288_07195	COG0318	PFAM AMP-dependent synthetase and ligase
N288_07210	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
N288_07215	COG1074	ATP-dependent DNA helicase activity
N288_07220	COG1403	HNH endonuclease
N288_07255	COG0318	PFAM AMP-dependent synthetase and ligase
N288_07265	COG2311	Membrane
N288_07275	COG0179	Fumarylacetoacetate (FAA) hydrolase
N288_07295	COG4585	Histidine kinase
N288_07300	COG2197	response regulator
N288_07305	COG1131	(ABC) transporter
N288_07310	COG0842	Transport permease protein
N288_07310	COG1511	domain protein
N288_07325	COG0367	asparagine synthase
N288_07345	COG1562	ergosterol biosynthetic process
N288_07350	COG0534	Mate efflux family protein
N288_07365	COG2182	Extracellular solute-binding protein
N288_07370	COG1175	transmembrane transport
N288_07375	COG3833	ABC-type maltose transport systems, permease component
N288_07380	COG0366	Alpha amylase catalytic
N288_07380	COG1874	Beta-galactosidase
N288_07390	COG1609	Transcriptional regulator
N288_07395	COG1028	Short-chain dehydrogenase reductase Sdr
N288_07405	COG1666	GTP binding
N288_07410	COG2996	Protein conserved in bacteria
N288_07420	COG1307	EDD domain protein, DegV family
N288_07425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N288_07445	COG0561	phosphatase activity
N288_07450	COG1073	alpha beta
N288_07455	COG2151	metal-sulfur cluster biosynthetic enzyme
N288_07465	COG0303	'Molybdopterin
N288_07475	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N288_07480	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N288_07485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N288_07505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N288_07530	COG2267	carboxylic ester hydrolase activity
N288_07545	COG1744	ABC transporter substrate-binding protein PnrA-like
N288_07560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N288_07565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N288_07570	COG5504	Zn-dependent protease
N288_07575	COG0444	Belongs to the ABC transporter superfamily
N288_07580	COG4608	Belongs to the ABC transporter superfamily
N288_07590	COG0601	transmembrane transport
N288_07595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N288_07610	COG0180	Tryptophanyl-tRNA synthetase
N288_07615	COG4166	transmembrane transport
N288_07620	COG0601	transmembrane transport
N288_07625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N288_07630	COG0444	Belongs to the ABC transporter superfamily
N288_07635	COG4608	Belongs to the ABC transporter superfamily
N288_07650	COG0456	acetyltransferase
N288_07655	COG1393	Belongs to the ArsC family
N288_07660	COG4862	establishment of competence for transformation
N288_07665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N288_07680	COG1164	Oligoendopeptidase f
N288_07695	COG2346	COG2346, Truncated hemoglobins
N288_07705	COG0741	lytic transglycosylase activity
N288_07710	COG4116	CYTH
N288_07720	COG2357	RelA SpoT domain protein
N288_07725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N288_07730	COG0564	pseudouridine synthase activity
N288_07735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N288_07740	COG2239	Acts as a magnesium transporter
N288_07745	COG0475	glutathione-regulated potassium exporter activity
N288_07745	COG0569	domain protein
N288_07750	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N288_07785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N288_07795	COG2323	membrane
N288_07805	COG1960	acyl-CoA dehydrogenase activity
N288_07810	COG1028	Short-chain dehydrogenase reductase Sdr
N288_07815	COG0318	PFAM AMP-dependent synthetase and ligase
N288_07820	COG1309	transcriptional regulator
N288_07825	COG1250	3-hydroxyacyl-CoA dehydrogenase
N288_07830	COG1024	Enoyl-CoA hydratase
N288_07850	COG1960	acyl-CoA dehydrogenase activity
N288_07870	COG0210	DNA helicase
N288_07880	COG2323	membrane
N288_07885	COG2153	protein acetylation
N288_07890	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
N288_07895	COG2382	esterase
N288_07920	COG3842	ATPase activity
N288_07935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N288_07950	COG2362	D-Aminopeptidase
N288_07955	COG0601	transmembrane transport
N288_07960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N288_07965	COG0444	Belongs to the ABC transporter superfamily
N288_07970	COG4166	transmembrane transport
N288_07975	COG1619	proteins homologs of microcin C7 resistance protein MccF
N288_07980	COG4948	Mandelate Racemase Muconate Lactonizing
N288_07985	COG0791	NLP P60 protein
N288_07990	COG4608	Belongs to the ABC transporter superfamily
N288_08010	COG0546	phosphoglycolate phosphatase activity
N288_08015	COG3871	stress protein (general stress protein 26)
N288_08045	COG0697	spore germination
N288_08090	COG0584	glycerophosphoryl diester phosphodiesterase
N288_08105	COG1585	Membrane protein implicated in regulation of membrane protease activity
N288_08110	COG2268	Band 7 protein
N288_08155	COG1404	Belongs to the peptidase S8 family
N288_08155	COG4412	M6 family metalloprotease domain protein
N288_08160	COG1595	DNA-templated transcription, initiation
N288_08170	COG1653	transport
N288_08175	COG1175	transmembrane transport
N288_08180	COG0395	ABC-type sugar transport system, permease component
N288_08195	COG1116	anion transmembrane transporter activity
N288_08200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N288_08215	COG3773	Cell wall hydrolase
N288_08225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N288_08230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N288_08230	COG1263	PTS System
N288_08235	COG0366	Alpha amylase catalytic
N288_08240	COG0366	Alpha amylase catalytic
N288_08245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N288_08250	COG1988	membrane-bound metal-dependent
N288_08255	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N288_08260	COG2200	EAL domain
N288_08265	COG0456	acetyltransferase
N288_08275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N288_08280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N288_08295	COG1191	sigma factor activity
N288_08310	COG0247	lactate metabolic process
N288_08315	COG0277	FAD linked oxidase domain protein
N288_08320	COG3835	regulator
N288_08325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N288_08350	COG3594	Acyltransferase
N288_08355	COG0840	transmembrane signaling receptor activity
N288_08365	COG5002	protein histidine kinase activity
N288_08380	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
N288_08385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N288_08390	COG0436	Aminotransferase
N288_08395	COG1850	ribulose-bisphosphate carboxylase activity
N288_08400	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
N288_08405	COG0235	Class ii aldolase
N288_08410	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
N288_08430	COG2223	nitrite transmembrane transporter activity
N288_08435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N288_08440	COG3852	Histidine kinase
N288_08445	COG0737	Belongs to the 5'-nucleotidase family
N288_08450	COG1846	Transcriptional regulator
N288_08460	COG5002	protein histidine kinase activity
N288_08465	COG0542	response to heat
N288_08470	COG3949	Membrane
N288_08485	COG0702	epimerase
N288_08490	COG4873	Protein conserved in bacteria
N288_08500	COG1028	Short-chain dehydrogenase reductase Sdr
N288_08515	COG0714	Associated with various cellular activities
N288_08540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N288_08550	COG1028	Short-chain dehydrogenase reductase Sdr
N288_08560	COG2084	Dehydrogenase
N288_08565	COG0436	Aminotransferase
N288_08570	COG1714	RDD family
N288_08580	COG1309	transcriptional regulator
N288_08595	COG0784	Response regulator, receiver
N288_08595	COG0835	chemotaxis
N288_08610	COG2814	Major facilitator Superfamily
N288_08620	COG1376	ErfK ybiS ycfS ynhG family protein
N288_08625	COG1408	metallophosphoesterase
N288_08630	COG1028	Short-chain dehydrogenase reductase Sdr
N288_08635	COG4990	cell redox homeostasis
N288_08645	COG2200	EAL domain
N288_08670	COG4703	Protein of unknown function (DUF1797)
N288_08680	COG0517	IMP dehydrogenase activity
N288_08690	COG0583	DNA-binding transcription factor activity
N288_08695	COG2171	N-acyltransferase activity
N288_08700	COG1473	amidohydrolase
N288_08705	COG0668	transmembrane transport
N288_08710	COG1132	(ABC) transporter
N288_08715	COG1132	(ABC) transporter
N288_08730	COG1271	oxidase subunit
N288_08735	COG1294	oxidase, subunit
N288_08740	COG0569	domain protein
N288_08745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N288_08760	COG0697	spore germination
N288_08765	COG0561	phosphatase activity
N288_08770	COG0242	peptide deformylase activity
N288_08785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N288_08790	COG0022	dehydrogenase e1 component
N288_08795	COG0508	dehydrogenase complex catalyzes the overall conversion of
N288_08805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N288_08815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N288_08820	COG0726	polysaccharide deacetylase
N288_08840	COG1982	Orn Lys Arg decarboxylase major
N288_08850	COG4476	Belongs to the UPF0223 family
N288_08855	COG4493	Belongs to the UPF0637 family
N288_08870	COG0483	inositol monophosphate 1-phosphatase activity
N288_08905	COG4896	Protein conserved in bacteria
N288_08920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N288_08925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N288_08935	COG0772	Belongs to the SEDS family
N288_08940	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
N288_08945	COG1612	heme a metabolic process
N288_08975	COG3336	cytochrome c oxidase
N288_09000	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
N288_09005	COG2340	Cysteine-rich secretory protein family
N288_09035	COG3679	Belongs to the UPF0342 family
N288_09040	COG4471	UPF0298 protein
N288_09055	COG0742	ribosomal rna small subunit methyltransferase
N288_09060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N288_09065	COG3314	Sporulation integral membrane protein YlbJ
N288_09070	COG1752	Esterase of the alpha-beta hydrolase superfamily
N288_09075	COG3480	Lon protease (S16) C-terminal proteolytic domain
N288_09080	COG1323	Belongs to the UPF0348 family
N288_09085	COG1399	metal-binding, possibly nucleic acid-binding protein
N288_09090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N288_09095	COG1024	Enoyl-CoA hydratase
N288_09105	COG0454	-acetyltransferase
N288_09110	COG0439	Biotin carboxylase
N288_09115	COG0511	ligase activity, forming carbon-carbon bonds
N288_09120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N288_09125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N288_09135	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
N288_09145	COG2001	Belongs to the MraZ family
N288_09155	COG4839	cell division protein FtsL
N288_09165	COG0768	penicillin binding
N288_09175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N288_09185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N288_09190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N288_09195	COG0772	Belongs to the SEDS family
N288_09215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N288_09220	COG3879	Bacterial protein of unknown function (DUF881)
N288_09225	COG3879	Bacterial protein of unknown function (DUF881)
N288_09230	COG3856	small basic protein
N288_09235	COG0849	cell division
N288_09240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N288_09250	COG1191	sigma factor activity
N288_09255	COG1191	sigma factor activity
N288_09260	COG1873	PFAM PRC-barrel domain
N288_09270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N288_09275	COG1799	cell septum assembly
N288_09280	COG0762	integral membrane protein
N288_09285	COG2302	S4 RNA-binding domain
N288_09290	COG3599	regulation of cell shape
N288_09305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N288_09310	COG0564	pseudouridine synthase activity
N288_09315	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N288_09330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N288_09340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N288_09350	COG0167	dihydroorotate dehydrogenase activity
N288_09355	COG0284	orotidine-5'-phosphate decarboxylase activity
N288_09360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N288_09375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N288_09380	COG1561	YicC-like family, N-terminal region
N288_09385	COG2052	Domain of unknown function (DUF370)
N288_09390	COG0194	GDP metabolic process
N288_09400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N288_09405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N288_09410	COG0242	peptide deformylase activity
N288_09420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N288_09420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N288_09425	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N288_09430	COG0631	protein serine/threonine phosphatase activity
N288_09435	COG0515	serine threonine protein kinase
N288_09435	COG2815	serine threonine protein kinase
N288_09445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N288_09450	COG1564	THIamine pyrophosphokinase
N288_09460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N288_09465	COG1302	Protein conserved in bacteria
N288_09470	COG1461	Dihydroxyacetone kinase
N288_09475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N288_09480	COG1349	DNA-binding transcription factor activity
N288_09485	COG0416	fatty acid biosynthetic process
N288_09490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N288_09495	COG1028	Short-chain dehydrogenase reductase Sdr
N288_09500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N288_09510	COG0571	ribonuclease III activity
N288_09515	COG1196	nuclear chromosome segregation
N288_09520	COG0552	protein localization to endoplasmic reticulum
N288_09530	COG1131	(ABC) transporter
N288_09545	COG0714	Associated with various cellular activities
N288_09565	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
N288_09570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N288_09580	COG1837	Belongs to the UPF0109 family
N288_09590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N288_09595	COG0336	Belongs to the RNA methyltransferase TrmD family
N288_09600	COG0335	large ribosomal subunit rRNA binding
N288_09630	COG2257	FlhB HrpN YscU SpaS Family
N288_09640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N288_09645	COG0758	DNA mediated transformation
N288_09650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N288_09655	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
N288_09660	COG4974	Belongs to the 'phage' integrase family
N288_09665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N288_09670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N288_09675	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
N288_09680	COG1815	bacterial-type flagellum-dependent cell motility
N288_09685	COG1558	bacterial-type flagellum-dependent cell motility
N288_09690	COG1677	Flagellar hook-basal body complex protein FliE
N288_09695	COG1766	The M ring may be actively involved in energy transduction
N288_09700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N288_09705	COG1317	bacterial-type flagellum organization
N288_09710	COG1157	protein secretion by the type III secretion system
N288_09715	COG2882	bacterial-type flagellum organization
N288_09730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N288_09740	COG4786	Flagellar basal body rod
N288_09745	COG1582	Flagellar protein (FlbD)
N288_09750	COG1580	Controls the rotational direction of flagella during chemotaxis
N288_09755	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N288_09760	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N288_09760	COG1776	CheC inhibitor of MCP methylation
N288_09765	COG2201	protein-glutamate methylesterase activity
N288_09770	COG3190	flagellar
N288_09775	COG1338	Plays a role in the flagellum-specific transport system
N288_09780	COG1987	bacterial-type flagellum assembly
N288_09785	COG1684	flagellar biosynthetic protein fliR
N288_09790	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N288_09795	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N288_09800	COG1419	protein localization to endoplasmic reticulum
N288_09805	COG0455	bacterial-type flagellum organization
N288_09810	COG2201	protein-glutamate methylesterase activity
N288_09815	COG0643	Histidine kinase
N288_09815	COG2198	Histidine kinase
N288_09820	COG0835	chemotaxis
N288_09825	COG1776	CheC inhibitor of MCP methylation
N288_09830	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
N288_09840	COG1191	sigma factor activity
N288_09865	COG0528	UMP kinase activity
N288_09870	COG0233	cytoplasmic translational termination
N288_09880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N288_09885	COG4589	Belongs to the CDS family
N288_09890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N288_09900	COG0750	zinc metalloprotease
N288_09910	COG3547	Transposase (IS116 IS110 IS902 family)
N288_09920	COG2176	DNA-directed DNA polymerase activity
N288_09925	COG0779	Required for maturation of 30S ribosomal subunits
N288_09930	COG0195	Participates in both transcription termination and antitermination
N288_09935	COG2740	Nucleic-acid-binding protein implicated in transcription termination
N288_09940	COG1358	cellular component organization or biogenesis
N288_09950	COG1550	Protein conserved in bacteria
N288_09960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N288_09965	COG0196	riboflavin kinase activity
N288_09970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N288_09975	COG1185	polyribonucleotide nucleotidyltransferase activity
N288_09985	COG0726	polysaccharide deacetylase
N288_09990	COG0612	Peptidase, M16
N288_09995	COG1873	PFAM PRC-barrel domain
N288_10005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N288_10010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N288_10020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N288_10025	COG0527	aspartate kinase activity
N288_10035	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N288_10040	COG0740	serine-type endopeptidase activity
N288_10055	COG1674	ftsk spoiiie
N288_10055	COG4980	gas vesicle protein
N288_10065	COG2188	Transcriptional regulator
N288_10090	COG3706	GGDEF domain
N288_10095	COG0612	Peptidase, M16
N288_10100	COG0612	Peptidase, M16
N288_10105	COG0300	oxidoreductase activity
N288_10120	COG1426	Protein conserved in bacteria
N288_10125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N288_10130	COG1058	Belongs to the CinA family
N288_10130	COG1546	Belongs to the CinA family
N288_10135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N288_10145	COG1692	metallophosphoesterase
N288_10150	COG2359	stage V sporulation protein S
N288_10160	COG0674	pyruvate-flavodoxin oxidoreductase activity
N288_10160	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N288_10165	COG1013	pyruvate-flavodoxin oxidoreductase activity
N288_10175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N288_10180	COG4550	Control of competence regulator ComK, YlbF/YmcA
N288_10195	COG0346	lactoylglutathione lyase activity
N288_10200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N288_10205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N288_10235	COG1077	Cell shape determining protein MreB Mrl
N288_10240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N288_10245	COG1923	regulation of RNA biosynthetic process
N288_10255	COG0464	growth
N288_10260	COG2860	membrane
N288_10265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N288_10270	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
N288_10275	COG0789	Transcriptional regulator
N288_10280	COG0174	glutamine synthetase
N288_10315	COG3620	sequence-specific DNA binding
N288_10335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N288_10340	COG1388	LysM domain
N288_10345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N288_10350	COG4224	UPF0291 protein
N288_10365	COG3763	UPF0154 protein
N288_10380	COG1132	(ABC) transporter
N288_10385	COG1132	(ABC) transporter
N288_10395	COG0785	Cytochrome C biogenesis protein
N288_10400	COG2201	protein-glutamate methylesterase activity
N288_10405	COG4846	Membrane protein involved in cytochrome C biogenesis
N288_10440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N288_10455	COG1028	Short-chain dehydrogenase reductase Sdr
N288_10470	COG0697	spore germination
N288_10490	COG1715	Restriction endonuclease
N288_10495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N288_10505	COG2222	sugar isomerase
N288_10510	COG1653	transport
N288_10515	COG1175	transmembrane transport
N288_10520	COG0395	ABC-type sugar transport system, permease component
N288_10525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N288_10530	COG2188	Transcriptional regulator
N288_10540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N288_10540	COG3711	transcriptional antiterminator
N288_10545	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N288_10550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N288_10560	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N288_10565	COG1447	Phosphotransferase system cellobiose-specific component IIA
N288_10570	COG1486	melibiose metabolic process
N288_10575	COG0583	DNA-binding transcription factor activity
N288_10580	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N288_10585	COG3773	Cell wall hydrolase
N288_10590	COG0579	oxidoreductase
N288_10620	COG0492	ferredoxin-NADP+ reductase activity
N288_10625	COG2226	methyltransferase
N288_10635	COG0653	protein targeting
N288_10660	COG1028	Short-chain dehydrogenase reductase Sdr
N288_10670	COG0840	transmembrane signaling receptor activity
N288_10670	COG5278	phosphoserine phosphatase activity
N288_10675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N288_10680	COG1794	racemase activity, acting on amino acids and derivatives
N288_10685	COG1132	(ABC) transporter
N288_10690	COG2755	lipolytic protein G-D-S-L family
N288_10695	COG2207	Transcriptional regulator
N288_10700	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
N288_10710	COG1073	alpha beta
N288_10715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N288_10730	COG0395	ABC-type sugar transport system, permease component
N288_10735	COG4209	transmembrane transport
N288_10740	COG5578	integral membrane protein
N288_10745	COG1653	transport
N288_10750	COG4677	pectinesterase activity
N288_10755	COG4677	pectinesterase activity
N288_10760	COG0657	acetylesterase activity
N288_10760	COG2755	lipolytic protein G-D-S-L family
N288_10770	COG0667	Aldo Keto reductase
N288_10775	COG1904	glucuronate isomerase
N288_10780	COG1609	Transcriptional regulator
N288_10785	COG0246	Mannitol dehydrogenase
N288_10790	COG2721	sulfolactate sulfo-lyase activity
N288_10805	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
N288_10810	COG1028	Short-chain dehydrogenase reductase Sdr
N288_10820	COG2720	vancomycin resistance protein
N288_10845	COG1966	Carbon starvation protein
N288_10860	COG2814	Major facilitator Superfamily
N288_10880	COG1278	Cold shock
N288_10890	COG0420	3'-5' exonuclease activity
N288_10895	COG0419	ATPase involved in DNA repair
N288_10910	COG1309	transcriptional regulator
N288_10920	COG5522	Integral membrane protein (intg_mem_TP0381)
N288_10940	COG5146	pantothenate kinase activity
N288_10950	COG2234	aminopeptidase activity
N288_10955	COG1388	LysM domain
N288_10955	COG0791	NLP P60 protein
N288_10960	COG1876	peptidase activity
N288_10965	COG1363	Peptidase, m42
N288_10970	COG5002	protein histidine kinase activity
N288_10975	COG0628	permease
N288_10980	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N288_10980	COG3264	Mechanosensitive ion channel
N288_10990	COG1388	LysM domain
N288_10990	COG0791	NLP P60 protein
N288_11010	COG2364	Membrane
N288_11015	COG1368	sulfuric ester hydrolase activity
N288_11030	COG1595	DNA-templated transcription, initiation
N288_11045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N288_11060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N288_11065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N288_11090	COG1760	l-serine dehydratase
N288_11095	COG1760	l-serine dehydratase
N288_11105	COG0500	methyltransferase
N288_11145	COG0494	nUDIX hydrolase
N288_11175	COG3706	GGDEF domain
N288_11190	COG1846	Transcriptional regulator
N288_11195	COG0477	Major facilitator Superfamily
N288_11200	COG3844	kynureninase activity
N288_11205	COG3844	kynureninase activity
N288_11210	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N288_11220	COG3973	AAA domain
N288_11235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N288_11245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N288_11255	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
N288_11260	COG3396	Phenylacetate-CoA oxygenase
N288_11275	COG2151	metal-sulfur cluster biosynthetic enzyme
N288_11285	COG1024	Enoyl-CoA hydratase
N288_11290	COG1250	3-hydroxyacyl-CoA dehydrogenase
N288_11295	COG0183	Belongs to the thiolase family
N288_11300	COG3327	negative regulation of DNA-templated transcription, initiation
N288_11305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N288_11310	COG2046	Belongs to the sulfate adenylyltransferase family
N288_11315	COG0529	Catalyzes the synthesis of activated sulfate
N288_11320	COG3273	potassium ion transport
N288_11320	COG0471	metal ion transport
N288_11330	COG1086	Polysaccharide biosynthesis protein
N288_11340	COG1086	Polysaccharide biosynthesis protein
N288_11345	COG1216	Glycosyl transferase, family 2
N288_11355	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
N288_11360	COG1091	dTDP-4-dehydrorhamnose reductase activity
N288_11365	COG1088	dTDP-glucose 4,6-dehydratase activity
N288_11370	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
N288_11415	COG1216	Glycosyl transferase, family 2
N288_11435	COG0438	transferase activity, transferring glycosyl groups
N288_11440	COG1216	Glycosyl transferase, family 2
N288_11485	COG2070	2-Nitropropane dioxygenase
N288_11495	COG4120	Belongs to the binding-protein-dependent transport system permease family
N288_11500	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N288_11525	COG0508	dehydrogenase complex catalyzes the overall conversion of
N288_11535	COG3185	4-Hydroxyphenylpyruvate dioxygenase
N288_11540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N288_11545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N288_11550	COG0179	Fumarylacetoacetate (FAA) hydrolase
N288_11565	COG1307	EDD domain protein, DegV family
N288_11575	COG1960	acyl-CoA dehydrogenase activity
N288_11580	COG0183	Belongs to the thiolase family
N288_11590	COG2323	membrane
N288_11595	COG3546	catalase activity
N288_11615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N288_11625	COG3437	response regulator, receiver
N288_11625	COG2770	Histidine kinase
N288_11685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N288_11700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N288_11720	COG0464	growth
N288_11725	COG0824	Thioesterase
N288_11735	COG4841	protein insertion into membrane
N288_11750	COG5002	protein histidine kinase activity
N288_11755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N288_11760	COG0254	rRNA binding
N288_11785	COG2233	PERMEase
N288_11795	COG1832	CoA-binding protein
N288_11800	COG0187	DNA topoisomerase II activity
N288_11805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N288_11810	COG1115	amino acid carrier protein
N288_11835	COG0590	tRNA wobble adenosine to inosine editing
N288_11840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
N288_11865	COG0709	Synthesizes selenophosphate from selenide and ATP
N288_11875	COG3639	organic phosphonate transmembrane transporter activity
N288_11880	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
N288_11890	COG0494	nUDIX hydrolase
N288_11895	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
N288_11900	COG0415	Belongs to the DNA photolyase family
N288_11905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N288_11940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N288_11945	COG1012	belongs to the aldehyde dehydrogenase family
N288_11970	COG0493	'glutamate synthase
N288_11980	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
N288_11990	COG1012	belongs to the aldehyde dehydrogenase family
N288_12005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N288_12010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N288_12020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N288_12030	COG2027	D-alanyl-D-alanine carboxypeptidase
N288_12050	COG1404	Belongs to the peptidase S8 family
N288_12065	COG0708	Exodeoxyribonuclease III
N288_12070	COG3663	DNA glycosylase
N288_12080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N288_12090	COG0840	transmembrane signaling receptor activity
N288_12095	COG1418	mRNA catabolic process
N288_12105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N288_12110	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_12115	COG0346	lactoylglutathione lyase activity
N288_12130	COG2814	Major facilitator Superfamily
N288_12135	COG2340	Cysteine-rich secretory protein family
N288_12140	COG1388	LysM domain
N288_12140	COG3858	chitin binding
N288_12160	COG4989	oxidoreductase activity
N288_12195	COG1388	LysM domain
N288_12195	COG3584	3D domain protein
N288_12205	COG1164	Oligoendopeptidase f
N288_12230	COG3361	conserved protein (COG2071)
N288_12270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N288_12275	COG1193	negative regulation of DNA recombination
N288_12280	COG1012	belongs to the aldehyde dehydrogenase family
N288_12285	COG1999	signal sequence binding
N288_12295	COG0488	(ABC) transporter
N288_12310	COG1686	Belongs to the peptidase S11 family
N288_12320	COG2404	hydrolase activity, acting on ester bonds
N288_12330	COG2340	Cysteine-rich secretory protein family
N288_12345	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N288_12350	COG1335	isochorismatase
N288_12360	COG1268	BioY protein
N288_12365	COG0392	lysyltransferase activity
N288_12365	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N288_12375	COG0706	membrane insertase activity
N288_12400	COG2105	PFAM AIG2 family protein
N288_12400	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
N288_12410	COG0318	PFAM AMP-dependent synthetase and ligase
N288_12420	COG0432	Pfam Uncharacterised protein family UPF0047
N288_12430	COG2746	aminoglycoside 3-N-acetyltransferase activity
N288_12445	COG0508	dehydrogenase complex catalyzes the overall conversion of
N288_12450	COG0567	Dehydrogenase, E1 component
N288_12465	COG0626	cystathionine gamma-synthase activity
N288_12470	COG0626	cystathionine gamma-synthase activity
N288_12475	COG0646	methionine synthase
N288_12475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N288_12480	COG1410	methionine synthase
N288_12480	COG0646	methionine synthase
N288_12490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N288_12495	COG1984	allophanate hydrolase subunit 2
N288_12500	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N288_12530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N288_12550	COG1253	flavin adenine dinucleotide binding
N288_12555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N288_12560	COG1834	amidinotransferase
N288_12575	COG0628	permease
N288_12605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N288_12615	COG1966	Carbon starvation protein
N288_12620	COG3279	Response regulator of the LytR AlgR family
N288_12645	COG1268	BioY protein
N288_12660	COG0726	polysaccharide deacetylase
N288_12680	COG0697	spore germination
N288_12685	COG1960	acyl-CoA dehydrogenase activity
N288_12710	COG0640	Transcriptional regulator
N288_12720	COG1664	Polymer-forming cytoskeletal
N288_12730	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_12745	COG1607	acyl-coa hydrolase
N288_12755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N288_12765	COG1176	ABC-type spermidine putrescine transport system, permease component I
N288_12815	COG0463	Glycosyl transferase, family 2
N288_12825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N288_12835	COG0534	Mate efflux family protein
N288_12850	COG3226	Transcriptional regulator
N288_12875	COG0697	spore germination
N288_12880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N288_12890	COG0242	peptide deformylase activity
N288_12895	COG5002	protein histidine kinase activity
N288_12905	COG0702	epimerase
N288_12915	COG0720	synthase
N288_12930	COG0561	phosphatase activity
N288_12935	COG0204	Acyl-transferase
N288_12960	COG1595	DNA-templated transcription, initiation
N288_12970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N288_12985	COG0456	acetyltransferase
N288_12990	COG1764	response to oxidative stress
N288_12995	COG0024	Methionine aminopeptidase
N288_13005	COG1733	regulation of RNA biosynthetic process
N288_13010	COG2514	catechol 2,3-dioxygenase activity
N288_13020	COG1028	Short-chain dehydrogenase reductase Sdr
N288_13030	COG0753	catalase activity
N288_13065	COG0352	thiamine-phosphate diphosphorylase activity
N288_13070	COG0351	phosphomethylpyrimidine kinase
N288_13080	COG5002	protein histidine kinase activity
N288_13090	COG0745	RESPONSE REGULATOR receiver
N288_13105	COG4990	cell redox homeostasis
N288_13115	COG2124	cytochrome p450
N288_13145	COG1595	DNA-templated transcription, initiation
N288_13170	COG1113	amino acid transport
N288_13190	COG0385	Bile acid
N288_13200	COG1272	protein, Hemolysin III
N288_13210	COG0697	spore germination
N288_13215	COG3403	YqcI/YcgG family
N288_13235	COG1959	2 iron, 2 sulfur cluster binding
N288_13255	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
N288_13260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N288_13270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N288_13275	COG0529	Catalyzes the synthesis of activated sulfate
N288_13280	COG2046	Belongs to the sulfate adenylyltransferase family
N288_13285	COG0306	phosphate transporter
N288_13320	COG0714	Associated with various cellular activities
N288_13360	COG1595	DNA-templated transcription, initiation
N288_13365	COG2197	response regulator
N288_13370	COG4585	Histidine kinase
N288_13375	COG3239	Fatty acid desaturase
N288_13405	COG4873	Protein conserved in bacteria
N288_13420	COG4166	transmembrane transport
N288_13450	COG2205	protein histidine kinase activity
N288_13475	COG3559	Exporter of polyketide antibiotics
N288_13480	COG1131	(ABC) transporter
N288_13485	COG1309	transcriptional regulator
N288_13520	COG0628	permease
N288_13525	COG1253	flavin adenine dinucleotide binding
N288_13545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N288_13550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N288_13555	COG0431	NADPH-dependent FMN reductase
N288_13565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N288_13595	COG3878	Protein conserved in bacteria
N288_13610	COG1028	Short-chain dehydrogenase reductase Sdr
N288_13625	COG1309	transcriptional regulator
N288_13655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N288_13675	COG0561	phosphatase activity
N288_13685	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N288_13690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N288_13695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N288_13700	COG0438	transferase activity, transferring glycosyl groups
N288_13760	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_13775	COG3708	Transcriptional regulator
N288_13775	COG2207	Transcriptional regulator
N288_13805	COG1132	(ABC) transporter
N288_13810	COG1132	(ABC) transporter
N288_13815	COG1846	Transcriptional regulator
N288_13825	COG3852	Histidine kinase
N288_13875	COG1114	Component of the transport system for branched-chain amino acids
N288_13880	COG1802	Transcriptional regulator
N288_13890	COG1012	belongs to the aldehyde dehydrogenase family
N288_13895	COG1454	alcohol dehydrogenase
N288_13900	COG0655	NAD(P)H dehydrogenase (quinone) activity
N288_13925	COG2202	Pas domain
N288_13925	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_13950	COG1393	Belongs to the ArsC family
N288_13990	COG1476	TRANSCRIPTIONal
N288_13995	COG3655	Transcriptional regulator
N288_14010	COG0456	acetyltransferase
N288_14015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N288_14020	COG0494	nUDIX hydrolase
N288_14045	COG1595	DNA-templated transcription, initiation
N288_14095	COG1368	sulfuric ester hydrolase activity
N288_14100	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N288_14110	COG0406	alpha-ribazole phosphatase activity
N288_14125	COG2318	DinB family
N288_14135	COG2814	Major facilitator Superfamily
N288_14145	COG2323	membrane
N288_14155	COG0667	Aldo Keto reductase
N288_14170	COG0395	ABC-type sugar transport system, permease component
N288_14175	COG1175	transmembrane transport
N288_14180	COG1653	transport
N288_14185	COG2723	6-phospho-beta-galactosidase activity
N288_14190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N288_14195	COG0400	carboxylic ester hydrolase activity
N288_14200	COG1357	PFAM Pentapeptide repeats (8 copies)
N288_14215	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N288_14285	COG1164	Oligoendopeptidase f
N288_14310	COG1368	sulfuric ester hydrolase activity
N288_14335	COG1476	TRANSCRIPTIONal
N288_14365	COG0523	cobalamin synthesis protein
N288_14375	COG0701	Predicted permease
N288_14380	COG3689	TIGRFAM TIGR03943 family protein
N288_14420	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_14425	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_14450	COG2226	methyltransferase
N288_14495	COG0860	N-Acetylmuramoyl-L-alanine amidase
N288_14500	COG0697	spore germination
N288_14505	COG0577	efflux transmembrane transporter activity
N288_14510	COG1136	(ABC) transporter
N288_14515	COG2205	protein histidine kinase activity
N288_14520	COG0745	RESPONSE REGULATOR receiver
N288_14535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N288_14540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N288_14550	COG0124	histidyl-tRNA synthetase
N288_14560	COG0753	catalase activity
N288_14570	COG3708	Transcriptional regulator
N288_14570	COG2207	Transcriptional regulator
N288_14575	COG0747	negative chemotaxis
N288_14580	COG0747	negative chemotaxis
N288_14585	COG1595	DNA-templated transcription, initiation
N288_14590	COG5002	protein histidine kinase activity
N288_14610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N288_14615	COG0501	Belongs to the peptidase M48B family
N288_14625	COG5002	protein histidine kinase activity
N288_14630	COG0745	RESPONSE REGULATOR receiver
N288_14645	COG0840	transmembrane signaling receptor activity
N288_14650	COG1088	dTDP-glucose 4,6-dehydratase activity
N288_14660	COG2267	carboxylic ester hydrolase activity
N288_14665	COG3679	Belongs to the UPF0342 family
N288_14700	COG1595	DNA-templated transcription, initiation
N288_14710	COG1476	TRANSCRIPTIONal
N288_14720	COG3340	Belongs to the peptidase S51 family
N288_14740	COG0534	Mate efflux family protein
N288_14765	COG1028	Short-chain dehydrogenase reductase Sdr
N288_14780	COG2233	PERMEase
N288_14790	COG0586	Pfam SNARE associated Golgi protein
N288_14800	COG3546	catalase activity
N288_14860	COG0477	Major facilitator Superfamily
N288_14865	COG1309	transcriptional regulator
N288_14870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N288_14885	COG0405	Gamma-glutamyltransferase
N288_14895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N288_14915	COG3181	Tripartite tricarboxylate transporter family receptor
N288_14920	COG4565	transcriptional regulatory protein
N288_14925	COG3290	protein histidine kinase activity
N288_14935	COG4572	Cation transport regulator
N288_14940	COG1346	cytolysis
N288_14945	COG1380	Effector of murein hydrolase LrgA
N288_14950	COG2814	Major facilitator Superfamily
N288_14955	COG1012	belongs to the aldehyde dehydrogenase family
N288_14990	COG0673	inositol 2-dehydrogenase activity
N288_15005	COG1408	metallophosphoesterase
N288_15020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N288_15040	COG1247	-acetyltransferase
N288_15055	COG1595	DNA-templated transcription, initiation
N288_15060	COG0322	excinuclease ABC activity
N288_15070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N288_15090	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
N288_15095	COG1131	(ABC) transporter
N288_15100	COG1131	(ABC) transporter
N288_15105	COG5002	protein histidine kinase activity
N288_15120	COG0628	permease
N288_15130	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_15145	COG0384	phenazine biosynthesis protein PhzF
N288_15155	COG4149	molybdate abc transporter
N288_15160	COG0778	Nitroreductase
N288_15180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N288_15190	COG0071	Belongs to the small heat shock protein (HSP20) family
N288_15210	COG0640	Transcriptional regulator
N288_15235	COG1253	flavin adenine dinucleotide binding
N288_15245	COG0840	transmembrane signaling receptor activity
N288_15250	COG3883	PFAM NLP P60 protein
N288_15250	COG0791	NLP P60 protein
N288_15270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
N288_15290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N288_15315	COG2217	Heavy metal translocating P-type atpase
N288_15320	COG2608	mercury ion transmembrane transporter activity
N288_15345	COG1902	pentaerythritol trinitrate reductase activity
N288_15350	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
N288_15360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N288_15360	COG1263	PTS System
N288_15390	COG0730	response to heat
N288_15400	COG4166	transmembrane transport
N288_15405	COG4608	Belongs to the ABC transporter superfamily
N288_15410	COG0444	Belongs to the ABC transporter superfamily
N288_15415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N288_15420	COG0601	transmembrane transport
N288_15425	COG2362	D-Aminopeptidase
N288_15430	COG1363	Peptidase, m42
N288_15435	COG1522	sequence-specific DNA binding
N288_15440	COG1228	amidohydrolase
N288_15450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N288_15455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N288_15460	COG1764	response to oxidative stress
N288_15465	COG0561	phosphatase activity
N288_15470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N288_15475	COG0471	metal ion transport
N288_15480	COG1737	Transcriptional regulator
N288_15495	COG0789	Transcriptional regulator
N288_15515	COG0456	acetyltransferase
N288_15520	COG3153	acetyltransferase
N288_15520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N288_15525	COG5001	Diguanylate cyclase
N288_15525	COG3300	MHYT domain
N288_15530	COG1132	(ABC) transporter
N288_15555	COG2135	peptidase activity
N288_15560	COG3546	catalase activity
N288_15570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N288_15575	COG2226	methyltransferase
N288_15615	COG0134	indole-3-glycerol-phosphate synthase activity
N288_15625	COG0512	Glutamine amidotransferase of anthranilate synthase
N288_15640	COG2258	MOSC domain
N288_15645	COG2814	Major facilitator Superfamily
N288_15650	COG0840	transmembrane signaling receptor activity
N288_15655	COG0596	Alpha beta hydrolase
N288_15685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N288_15685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N288_15685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N288_15690	COG1105	Belongs to the carbohydrate kinase PfkB family
N288_15695	COG1349	DNA-binding transcription factor activity
N288_15705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N288_15710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N288_15720	COG0010	Belongs to the arginase family
N288_15725	COG1228	amidohydrolase
N288_15730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N288_15740	COG4129	membrane
N288_15770	COG2814	Major facilitator Superfamily
N288_15775	COG0745	RESPONSE REGULATOR receiver
N288_15780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N288_15785	COG0784	Response regulator, receiver
N288_15785	COG2205	protein histidine kinase activity
N288_15795	COG2239	Acts as a magnesium transporter
N288_15800	COG1280	lysine exporter protein (LysE YggA)
N288_15825	COG2755	lipolytic protein G-D-S-L family
N288_15830	COG3852	Histidine kinase
N288_15870	COG1278	Cold shock
N288_15875	COG0513	Belongs to the DEAD box helicase family
N288_15880	COG1278	Cold shock
N288_15885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N288_15895	COG0671	phosphoesterase, PA-phosphatase related
N288_15900	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N288_15905	COG1793	dna ligase
N288_15905	COG3285	dna ligase
N288_15910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N288_15920	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N288_15930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N288_15935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N288_15935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N288_15940	COG0307	riboflavin synthase, alpha
N288_15945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N288_15945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N288_15950	COG2217	Heavy metal translocating P-type atpase
N288_15955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N288_15970	COG4667	esterase of the alpha-beta hydrolase superfamily
N288_15985	COG0586	Pfam SNARE associated Golgi protein
N288_15990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N288_16015	COG0668	transmembrane transport
N288_16020	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N288_16025	COG1028	Short-chain dehydrogenase reductase Sdr
N288_16045	COG2340	Cysteine-rich secretory protein family
N288_16050	COG2205	protein histidine kinase activity
N288_16055	COG0745	RESPONSE REGULATOR receiver
N288_16080	COG1846	Transcriptional regulator
N288_16085	COG0523	cobalamin synthesis protein
N288_16090	COG1316	TRANSCRIPTIONal
N288_16095	COG3409	Peptidoglycan-binding domain 1 protein
N288_16095	COG0793	Belongs to the peptidase S41A family
N288_16105	COG1876	peptidase activity
N288_16135	COG4326	sporulation control protein
N288_16160	COG4479	Belongs to the UPF0346 family
N288_16170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N288_16185	COG1509	lysine 2,3-aminomutase activity
N288_16190	COG3829	transcription factor binding
N288_16195	COG0456	acetyltransferase
N288_16200	COG1012	belongs to the aldehyde dehydrogenase family
N288_16205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N288_16210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N288_16215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N288_16220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N288_16235	COG5278	phosphoserine phosphatase activity
N288_16235	COG0840	transmembrane signaling receptor activity
N288_16255	COG2190	(PTS) system
N288_16260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N288_16290	COG2755	lipolytic protein G-D-S-L family
N288_16295	COG1999	signal sequence binding
N288_16320	COG1307	EDD domain protein, DegV family
N288_16335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N288_16345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N288_16350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N288_16360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N288_16370	COG2310	stress, protein
N288_16375	COG2310	stress, protein
N288_16380	COG3853	Toxic anion resistance protein (TelA)
N288_16415	COG0861	Integral membrane protein TerC family
N288_16420	COG2310	stress, protein
N288_16430	COG0436	Aminotransferase
N288_16435	COG2136	Putative SAM-dependent methyltransferase
N288_16435	COG2521	methyltransferase
N288_16445	COG0129	dihydroxy-acid dehydratase activity
N288_16450	COG1413	lyase activity
N288_16455	COG0488	(ABC) transporter
N288_16460	COG1418	mRNA catabolic process
N288_16465	COG1307	EDD domain protein, DegV family
N288_16480	COG0386	Belongs to the glutathione peroxidase family
N288_16520	COG1321	iron dependent repressor
N288_16530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N288_16535	COG1321	iron dependent repressor
N288_16535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N288_16540	COG1121	(ABC) transporter
N288_16545	COG0803	Belongs to the bacterial solute-binding protein 9 family
N288_16565	COG1278	Cold shock
N288_16575	COG0328	RNA-DNA hybrid ribonuclease activity
N288_16580	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N288_16585	COG0328	RNA-DNA hybrid ribonuclease activity
N288_16600	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
N288_16610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N288_16630	COG3541	Predicted nucleotidyltransferase
N288_16635	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
N288_16640	COG1755	Isoprenylcysteine carboxyl methyltransferase
N288_16645	COG3424	synthase
N288_16655	COG1028	Short-chain dehydrogenase reductase Sdr
N288_16680	COG2233	PERMEase
N288_16695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N288_16700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N288_16710	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
N288_16720	COG1199	ATP-dependent helicase activity
N288_16730	COG0116	Belongs to the methyltransferase superfamily
N288_16750	COG4474	Belongs to the UPF0398 family
N288_16765	COG3359	exonuclease
N288_16770	COG1205	dead DEAH box helicase
N288_16770	COG1111	helicase
N288_16795	COG0601	transmembrane transport
N288_16830	COG3331	DNA recombination
N288_16835	COG4499	WXG100 protein secretion system (Wss), protein YukC
N288_16835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N288_16845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N288_16850	COG3935	DnaD domain protein
N288_16875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N288_16875	COG1199	ATP-dependent helicase activity
N288_16885	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N288_16890	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N288_16910	COG0617	tRNA 3'-terminal CCA addition
N288_16915	COG0438	transferase activity, transferring glycosyl groups
N288_16920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N288_16925	COG1803	Methylglyoxal synthase
N288_16930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N288_16935	COG1694	Mazg nucleotide pyrophosphohydrolase
N288_16940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N288_16945	COG2738	Putative neutral zinc metallopeptidase
N288_16955	COG4347	Protein of unknown function (DUF1405)
N288_16965	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N288_16980	COG5582	Belongs to the UPF0302 family
N288_16985	COG0457	Tetratricopeptide repeat
N288_17000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N288_17005	COG0287	Prephenate dehydrogenase
N288_17010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N288_17015	COG4401	Chorismate mutase type I
N288_17020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N288_17025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N288_17030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N288_17035	COG0105	UTP biosynthetic process
N288_17040	COG0142	geranyltranstransferase activity
N288_17045	COG2226	methyltransferase
N288_17050	COG0142	geranyltranstransferase activity
N288_17060	COG0302	gtp cyclohydrolase
N288_17065	COG0776	regulation of translation
N288_17070	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
N288_17090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N288_17120	COG1304	FMN binding
N288_17125	COG0539	negative regulation of cytoplasmic translation
N288_17130	COG0204	Acyl-transferase
N288_17135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N288_17150	COG2959	enzyme of heme biosynthesis
N288_17155	COG3409	Peptidoglycan-binding domain 1 protein
N288_17155	COG3773	Cell wall hydrolase
N288_17160	COG2339	peptidase activity
N288_17170	COG0492	ferredoxin-NADP+ reductase activity
N288_17175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N288_17180	COG4862	establishment of competence for transformation
N288_17190	COG1408	metallophosphoesterase
N288_17215	COG1388	LysM domain
N288_17220	COG1266	CAAX protease self-immunity
N288_17225	COG0514	ATP-dependent DNA helicase (RecQ)
N288_17230	COG4955	Helix-turn-helix domain
N288_17235	COG1141	Ferredoxin
N288_17240	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
N288_17245	COG0693	protein deglycase activity
N288_17255	COG0789	Transcriptional regulator
N288_17265	COG0733	neurotransmitter:sodium symporter activity
N288_17270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N288_17275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
N288_17280	COG0739	heme binding
N288_17290	COG1595	DNA-templated transcription, initiation
N288_17295	COG5002	protein histidine kinase activity
N288_17300	COG0745	RESPONSE REGULATOR receiver
N288_17305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N288_17310	COG1333	cytochrome c biogenesis protein
N288_17315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N288_17320	COG1187	pseudouridine synthase activity
N288_17325	COG0700	Nucleoside recognition
N288_17330	COG2715	membrane protein required for spore maturation
N288_17335	COG1686	Belongs to the peptidase S11 family
N288_17340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N288_17365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N288_17370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N288_17380	COG1547	Domain of unknown function (DUF309)
N288_17395	COG4086	secreted protein
N288_17405	COG0697	spore germination
N288_17430	COG2172	sigma factor antagonist activity
N288_17440	COG1686	Belongs to the peptidase S11 family
N288_17460	COG4974	Belongs to the 'phage' integrase family
N288_17475	COG0735	belongs to the Fur family
N288_17480	COG1300	Membrane
N288_17490	COG1379	DNA repair
N288_17505	COG0667	Aldo Keto reductase
N288_17510	COG0456	acetyltransferase
N288_17510	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N288_17530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N288_17540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N288_17550	COG1073	alpha beta
N288_17575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N288_17585	COG0300	oxidoreductase activity
N288_17590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N288_17595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N288_17600	COG1216	Glycosyl transferase, family 2
N288_17605	COG1902	pentaerythritol trinitrate reductase activity
N288_17620	COG1234	tRNA 3'-trailer cleavage
N288_17625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N288_17630	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N288_17635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N288_17645	COG0835	chemotaxis
N288_17650	COG2195	Cleaves the N-terminal amino acid of tripeptides
N288_17655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N288_17660	COG0346	lactoylglutathione lyase activity
N288_17670	COG1376	ErfK ybiS ycfS ynhG family protein
N288_17675	COG4129	membrane
N288_17680	COG1126	abc transporter atp-binding protein
N288_17685	COG0765	amino acid transport
N288_17695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N288_17705	COG1703	isobutyryl-CoA mutase activity
N288_17710	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N288_17710	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N288_17715	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N288_17720	COG0508	dehydrogenase complex catalyzes the overall conversion of
N288_17725	COG0022	dehydrogenase e1 component
N288_17730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N288_17735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N288_17740	COG3426	butyrate kinase activity
N288_17750	COG0280	phosphate acetyltransferase
N288_17755	COG3829	transcription factor binding
N288_17755	COG3290	protein histidine kinase activity
N288_17765	COG3093	addiction module antidote protein HigA
N288_17775	COG0745	RESPONSE REGULATOR receiver
N288_17785	COG0750	zinc metalloprotease
N288_17790	COG0497	DNA recombination
N288_17800	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
N288_17805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N288_17820	COG1722	exodeoxyribonuclease VII activity
N288_17825	COG1570	exodeoxyribonuclease VII activity
N288_17830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N288_17835	COG1302	Protein conserved in bacteria
N288_17840	COG0439	Biotin carboxylase
N288_17845	COG0511	ligase activity, forming carbon-carbon bonds
N288_17850	COG0840	transmembrane signaling receptor activity
N288_17850	COG5278	phosphoserine phosphatase activity
N288_17895	COG3854	ATPases associated with a variety of cellular activities
N288_17905	COG2968	Membrane
N288_17915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N288_17920	COG0006	proline dipeptidase activity
N288_17925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N288_17935	COG3872	metal-dependent enzyme
N288_17945	COG1752	Esterase of the alpha-beta hydrolase superfamily
N288_17955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N288_17965	COG0095	Lipoate-protein ligase
N288_17970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N288_17975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N288_17980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N288_17985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N288_17995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N288_18015	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N288_18040	COG4537	Required for transformation and DNA binding
N288_18045	COG1459	type II secretion system
N288_18050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N288_18060	COG1393	Belongs to the ArsC family
N288_18080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N288_18095	COG0011	TIGRFAM Protein of
N288_18110	COG1368	sulfuric ester hydrolase activity
N288_18120	COG1940	carbohydrate kinase activity
N288_18135	COG0697	spore germination
N288_18140	COG0705	Rhomboid family
N288_18140	COG0457	Tetratricopeptide repeat
N288_18155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N288_18160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N288_18170	COG0438	transferase activity, transferring glycosyl groups
N288_18190	COG0704	Plays a role in the regulation of phosphate uptake
N288_18195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N288_18200	COG0581	inorganic phosphate transmembrane transporter activity
N288_18205	COG0573	inorganic phosphate transmembrane transporter activity
N288_18210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N288_18225	COG0477	Major facilitator Superfamily
N288_18235	COG2839	Protein conserved in bacteria
N288_18240	COG1283	sodium-dependent phosphate transmembrane transporter activity
N288_18245	COG5521	maltodextrose utilization protein MalA
N288_18250	COG0840	transmembrane signaling receptor activity
N288_18265	COG4709	membrane
N288_18270	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
N288_18275	COG0735	belongs to the Fur family
N288_18280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N288_18285	COG1121	(ABC) transporter
N288_18295	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N288_18300	COG0513	Belongs to the DEAD box helicase family
N288_18315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N288_18320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N288_18325	COG2384	SAM-dependent methyltransferase
N288_18330	COG2010	Cytochrome c
N288_18335	COG1960	acyl-CoA dehydrogenase activity
N288_18345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N288_18350	COG0358	DNA primase activity
N288_18355	COG1671	Belongs to the UPF0178 family
N288_18360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N288_18365	COG0517	IMP dehydrogenase activity
N288_18370	COG0751	glycine-tRNA ligase activity
N288_18380	COG1381	Involved in DNA repair and RecF pathway recombination
N288_18390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N288_18395	COG0295	cytidine deaminase activity
N288_18400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N288_18410	COG1480	7TM receptor with intracellular HD hydrolase
N288_18415	COG1702	phosphate starvation-inducible protein PhoH
N288_18435	COG4864	UPF0365 protein
N288_18440	COG1030	water channel activity
N288_18445	COG1610	YqeY-like protein
N288_18450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N288_18455	COG1283	sodium-dependent phosphate transmembrane transporter activity
N288_18460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N288_18465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N288_18470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N288_18475	COG2264	protein methyltransferase activity
N288_18485	COG0443	Heat shock 70 kDa protein
N288_18490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N288_18500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N288_18505	COG0481	GTPase activity
N288_18515	COG0860	N-Acetylmuramoyl-L-alanine amidase
N288_18525	COG0268	Binds directly to 16S ribosomal RNA
N288_18530	COG1466	dna polymerase III delta subunit
N288_18540	COG0658	competence protein
N288_18540	COG2333	competence protein COMEC
N288_18545	COG2131	deaminase
N288_18550	COG1555	photosystem II stabilization
N288_18550	COG1596	polysaccharide export
N288_18555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N288_18560	COG2226	methyltransferase
N288_18565	COG0799	negative regulation of ribosome biogenesis
N288_18570	COG1713	HD superfamily hydrolase involved in NAD metabolism
N288_18575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N288_18580	COG1534	Rna-binding protein
N288_18590	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N288_18595	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
N288_18605	COG0688	phosphatidylethanolamine metabolic process
N288_18610	COG1183	phosphatidylcholine synthase activity
N288_18615	COG1164	Oligoendopeptidase f
N288_18655	COG0626	cystathionine gamma-synthase activity
N288_18660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N288_18665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N288_18670	COG2226	methyltransferase
N288_18685	COG0768	penicillin binding
N288_18690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N288_18695	COG0572	uridine kinase
N288_18715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N288_18720	COG3906	Belongs to the UPF0473 family
N288_18730	COG4472	Bacterial protein of unknown function (DUF965)
N288_18740	COG0628	permease
N288_18765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N288_18775	COG0482	sulfurtransferase activity
N288_18780	COG1104	cysteine desulfurase activity
N288_18785	COG1959	2 iron, 2 sulfur cluster binding
N288_18790	COG2364	Membrane
N288_18795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N288_18805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N288_18810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N288_18815	COG0124	histidyl-tRNA synthetase
N288_18825	COG4991	sh3 domain protein
N288_18825	COG3103	Sh3 type 3 domain protein
N288_18825	COG0860	N-Acetylmuramoyl-L-alanine amidase
N288_18830	COG1490	D-aminoacyl-tRNA deacylase activity
N288_18835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N288_18840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N288_18845	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
N288_18845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N288_18850	COG5416	Lipopolysaccharide assembly protein A domain
N288_18855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N288_18860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N288_18860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N288_18870	COG2244	polysaccharide biosynthetic process
N288_18875	COG2323	membrane
N288_18885	COG1862	Preprotein translocase
N288_18895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N288_18940	COG1388	LysM domain
N288_18945	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N288_18950	COG0157	Belongs to the NadC ModD family
N288_18955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N288_18960	COG1104	cysteine desulfurase activity
N288_18965	COG1827	regulation of RNA biosynthetic process
N288_18970	COG0077	Prephenate dehydratase
N288_18975	COG4492	Belongs to the UPF0735 family
N288_18980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N288_18985	COG3290	protein histidine kinase activity
N288_18995	COG2868	ribosomal protein
N288_19000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N288_19005	COG1530	ribonuclease E activity
N288_19010	COG1994	Peptidase M50
N288_19015	COG0739	heme binding
N288_19025	COG2894	cell division
N288_19030	COG0850	regulation of cytokinetic process
N288_19045	COG1792	Involved in formation and maintenance of cell shape
N288_19050	COG1077	Cell shape determining protein MreB Mrl
N288_19055	COG2003	Belongs to the UPF0758 family
N288_19060	COG0424	maF-like protein
N288_19090	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
N288_19110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N288_19150	COG0745	RESPONSE REGULATOR receiver
N288_19150	COG3706	GGDEF domain
N288_19155	COG0285	dihydrofolate synthase activity
N288_19160	COG0525	valine-tRNA ligase activity
N288_19170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N288_19175	COG1388	LysM domain
N288_19180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N288_19185	COG0113	porphobilinogen synthase activity
N288_19200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N288_19215	COG1126	abc transporter atp-binding protein
N288_19220	COG0765	amino acid transport
N288_19225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N288_19235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N288_19240	COG1067	ATP-dependent peptidase activity
N288_19240	COG0470	DNA polymerase III
N288_19245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N288_19250	COG0544	peptidyl-prolyl cis-trans isomerase activity
N288_19255	COG0457	Tetratricopeptide repeat
N288_19255	COG1477	protein flavinylation
N288_19260	COG0066	3-isopropylmalate dehydratase activity
N288_19265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N288_19270	COG0473	3-isopropylmalate dehydrogenase activity
N288_19275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N288_19280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N288_19285	COG0440	acetolactate synthase activity
N288_19290	COG0028	Belongs to the TPP enzyme family
N288_19295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N288_19305	COG0622	Phosphoesterase
N288_19310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N288_19320	COG5401	PFAM Sporulation and spore germination
N288_19325	COG0514	ATP-dependent DNA helicase (RecQ)
N288_19330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N288_19335	COG1846	Transcriptional regulator
N288_19340	COG2197	response regulator
N288_19345	COG0824	Thioesterase
N288_19350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N288_19355	COG1053	succinate dehydrogenase
N288_19360	COG2009	succinate dehydrogenase
N288_19370	COG1719	4-vinyl reductase, 4VR
N288_19380	COG0322	excinuclease ABC activity
N288_19390	COG3118	belongs to the thioredoxin family
N288_19395	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
N288_19400	COG2086	electron transfer activity
N288_19405	COG1024	Enoyl-CoA hydratase
N288_19410	COG1309	transcriptional regulator
N288_19415	COG0318	PFAM AMP-dependent synthetase and ligase
N288_19420	COG3766	membrane
N288_19430	COG1796	DNA polymerase
N288_19430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
N288_19435	COG1286	toxin biosynthetic process
N288_19440	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
N288_19445	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N288_19450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N288_19450	COG0072	phenylalanine-tRNA ligase activity
N288_19455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N288_19460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N288_19470	COG1363	Peptidase, m42
N288_19490	COG3326	Membrane
N288_19495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N288_19505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N288_19510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N288_19520	COG1484	DNA-dependent DNA replication
N288_19525	COG3611	Membrane attachment protein
N288_19530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N288_19540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
N288_19545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N288_19550	COG0237	dephospho-CoA kinase activity
N288_19555	COG1971	Probably functions as a manganese efflux pump
N288_19560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N288_19565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N288_19565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N288_19570	COG0330	HflC and HflK could
N288_19575	COG0330	HflC and HflK could
N288_19580	COG5002	protein histidine kinase activity
N288_19585	COG0745	RESPONSE REGULATOR receiver
N288_19595	COG0039	L-malate dehydrogenase activity
N288_19600	COG0538	isocitrate dehydrogenase activity
N288_19605	COG0372	Belongs to the citrate synthase family
N288_19610	COG2707	UPF0756 membrane protein
N288_19620	COG0628	permease
N288_19625	COG3030	protein affecting phage T7 exclusion by the F plasmid
N288_19645	COG0825	malonyl-CoA metabolic process
N288_19655	COG2186	Transcriptional regulator
N288_19660	COG0281	malic enzyme
N288_19665	COG0587	DNA-directed DNA polymerase activity
N288_19680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N288_19690	COG4109	DRTGG domain
N288_19700	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N288_19705	COG0006	proline dipeptidase activity
N288_19725	COG0589	response to stress
N288_19730	COG0165	Argininosuccinate lyase
N288_19735	COG0137	argininosuccinate synthase activity
N288_19745	COG0521	Mo-molybdopterin cofactor biosynthetic process
N288_19755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N288_19760	COG0827	DNA restriction-modification system
N288_19765	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
N288_19770	COG3874	Sporulation protein YtfJ
N288_19780	COG1714	RDD family
N288_19785	COG0616	signal peptide processing
N288_19790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N288_19795	COG2962	Rard protein
N288_19800	COG1574	metal-dependent hydrolase with the TIM-barrel fold
N288_19805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N288_19815	COG0301	tRNA thio-modification
N288_19820	COG1104	cysteine desulfurase activity
N288_19825	COG1114	Component of the transport system for branched-chain amino acids
N288_19830	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
N288_19835	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
N288_19840	COG1309	transcriptional regulator
N288_19845	COG1956	GAF domain-containing protein
N288_19855	COG0626	cystathionine gamma-synthase activity
N288_19860	COG2199	diguanylate cyclase activity
N288_19860	COG2203	Gaf domain
N288_19870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N288_19885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N288_19890	COG0454	-acetyltransferase
N288_19895	COG0517	IMP dehydrogenase activity
N288_19900	COG0123	including yeast histone deacetylase and acetoin utilization protein
N288_19925	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
N288_19925	COG1605	Chorismate mutase
N288_19935	COG3118	belongs to the thioredoxin family
N288_19940	COG4980	gas vesicle protein
N288_19945	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
N288_19950	COG2309	aminopeptidase activity
N288_19955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N288_19970	COG1674	ftsk spoiiie
N288_19975	COG4848	Belongs to the UPF0354 family
N288_19980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N288_20000	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
N288_20005	COG1363	Peptidase, m42
N288_20010	COG5584	Small secreted protein
N288_20015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N288_20020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N288_20040	COG0510	thiamine kinase activity
N288_20045	COG1523	belongs to the glycosyl hydrolase 13 family
N288_20065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N288_20075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N288_20080	COG4473	ABC transporter
N288_20085	COG1131	(ABC) transporter
N288_20100	COG1187	pseudouridine synthase activity
N288_20110	COG2244	polysaccharide biosynthetic process
N288_20115	COG2081	HI0933 family
N288_20125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N288_20130	COG0495	leucyl-tRNA aminoacylation
N288_20140	COG1028	Short-chain dehydrogenase reductase Sdr
N288_20145	COG2610	gluconate transmembrane transporter activity
N288_20150	COG3290	protein histidine kinase activity
N288_20150	COG3829	transcription factor binding
N288_20160	COG2814	Major facilitator Superfamily
N288_20165	COG2267	carboxylic ester hydrolase activity
N288_20185	COG1242	4 iron, 4 sulfur cluster binding
N288_20190	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
N288_20200	COG2267	carboxylic ester hydrolase activity
N288_20205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N288_20210	COG4990	cell redox homeostasis
N288_20215	COG0367	asparagine synthase
N288_20220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N288_20240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N288_20245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N288_20255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N288_20280	COG0583	DNA-binding transcription factor activity
N288_20285	COG0372	Belongs to the citrate synthase family
N288_20295	COG1506	peptidase
N288_20300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N288_20305	COG1116	anion transmembrane transporter activity
N288_20310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N288_20315	COG0494	nUDIX hydrolase
N288_20340	COG0783	Belongs to the Dps family
N288_20350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N288_20355	COG1854	S-ribosylhomocysteine lyase activity
N288_20360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N288_20365	COG0288	reversible hydration of carbon dioxide
N288_20375	COG1271	oxidase subunit
N288_20380	COG1294	oxidase, subunit
N288_20395	COG4948	Mandelate Racemase Muconate Lactonizing
N288_20400	COG0318	PFAM AMP-dependent synthetase and ligase
N288_20405	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N288_20410	COG0596	Alpha beta hydrolase
N288_20415	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
N288_20420	COG1169	isochorismate synthase
N288_20425	COG1575	Belongs to the MenA family. Type 1 subfamily
N288_20430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N288_20435	COG0058	SHG alpha-glucan phosphorylase activity
N288_20440	COG0297	glycogen (starch) synthase activity
N288_20445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N288_20595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N288_20605	COG1285	pathogenesis
N288_20620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N288_20625	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
N288_20630	COG0673	inositol 2-dehydrogenase activity
N288_20635	COG1028	Short-chain dehydrogenase reductase Sdr
N288_20645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N288_20665	COG1979	alcohol dehydrogenase
N288_20670	COG2155	Conserved Protein
N288_20675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N288_20680	COG3829	transcription factor binding
N288_20685	COG1098	S1 RNA binding domain
N288_20695	COG0436	Aminotransferase
N288_20700	COG1522	sequence-specific DNA binding
N288_20710	COG2267	carboxylic ester hydrolase activity
N288_20720	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N288_20730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N288_20740	COG5018	Exonuclease
N288_20745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N288_20770	COG2111	Na H antiporter
N288_20775	COG1006	Multisubunit Na H antiporter MnhC subunit
N288_20780	COG0651	ATP synthesis coupled electron transport
N288_20785	COG1863	multisubunit Na H antiporter MnhE subunit
N288_20790	COG2212	antiporter activity
N288_20795	COG1320	monovalent cation:proton antiporter activity
N288_20800	COG2050	protein possibly involved in aromatic compounds catabolism
N288_20840	COG1028	Short-chain dehydrogenase reductase Sdr
N288_20860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N288_20865	COG2056	Na+-H+ antiporter family
N288_20870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N288_20880	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
N288_20890	COG3584	3D domain protein
N288_20905	COG0494	nUDIX hydrolase
N288_20910	COG1252	NADH dehydrogenase
N288_20915	COG0492	ferredoxin-NADP+ reductase activity
N288_20940	COG0316	Belongs to the HesB IscA family
N288_20950	COG4844	belongs to the
N288_20955	COG1252	NADH dehydrogenase
N288_20960	COG4837	Protein of unknown function (DUF1462)
N288_20965	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
N288_20975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N288_20980	COG0460	homoserine dehydrogenase
N288_20990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N288_20995	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N288_21000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N288_21010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N288_21015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N288_21020	COG0647	UMP catabolic process
N288_21025	COG2445	Protein of unknown function DUF86
N288_21030	COG5001	Diguanylate cyclase
N288_21030	COG3300	MHYT domain
N288_21045	COG4470	Protein conserved in bacteria
N288_21055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N288_21060	COG0739	heme binding
N288_21070	COG0733	neurotransmitter:sodium symporter activity
N288_21075	COG1757	Na H antiporter
N288_21095	COG3377	Domain of unknown function (DUF1805)
N288_21100	COG0737	Belongs to the 5'-nucleotidase family
N288_21105	COG1801	Protein of unknown function DUF72
N288_21110	COG0719	Fe-S assembly protein
N288_21115	COG0822	iron-sulfur transferase activity
N288_21120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N288_21125	COG0719	Fe-S assembly protein
N288_21130	COG0396	ATPase activity
N288_21140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N288_21145	COG1464	Belongs to the NlpA lipoprotein family
N288_21150	COG2011	ABC-type metal ion transport system permease component
N288_21155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N288_21175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N288_21180	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
N288_21195	COG0509	glycine decarboxylation via glycine cleavage system
N288_21200	COG1393	Belongs to the ArsC family
N288_21205	COG1960	acyl-CoA dehydrogenase activity
N288_21210	COG0183	Belongs to the thiolase family
N288_21215	COG1024	Enoyl-CoA hydratase
N288_21215	COG1250	3-hydroxyacyl-CoA dehydrogenase
N288_21235	COG0506	proline dehydrogenase activity
N288_21250	COG1120	ATPase activity
N288_21255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N288_21260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N288_21265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N288_21285	COG0772	Belongs to the SEDS family
N288_21355	COG0004	ammonium transporteR
N288_21360	COG2427	Protein of unknown function (DUF1641)
N288_21365	COG3383	formate dehydrogenase (NAD+) activity
N288_21380	COG4990	cell redox homeostasis
N288_21390	COG1733	regulation of RNA biosynthetic process
N288_21395	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
N288_21400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N288_21405	COG0300	oxidoreductase activity
N288_21415	COG0730	response to heat
N288_21420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N288_21420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N288_21425	COG0425	Belongs to the sulfur carrier protein TusA family
N288_21425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N288_21430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N288_21435	COG2210	Belongs to the sulfur carrier protein TusA family
N288_21440	COG0425	Belongs to the sulfur carrier protein TusA family
N288_21445	COG1937	Protein conserved in bacteria
N288_21470	COG4152	abc transporter atp-binding protein
N288_21475	COG1121	(ABC) transporter
N288_21490	COG0840	transmembrane signaling receptor activity
N288_21495	COG2409	Drug exporters of the RND superfamily
N288_21495	COG1033	growth of symbiont in host cell
N288_21500	COG1846	Transcriptional regulator
N288_21510	COG0517	IMP dehydrogenase activity
N288_21510	COG1125	glycine betaine transport
N288_21515	COG3706	GGDEF domain
N288_21525	COG1174	glycine betaine transport
N288_21530	COG1125	glycine betaine transport
N288_21530	COG0517	IMP dehydrogenase activity
N288_21540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N288_21545	COG0655	NAD(P)H dehydrogenase (quinone) activity
N288_21560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N288_21565	COG0557	exoribonuclease II activity
N288_21570	COG1647	Serine aminopeptidase, S33
N288_21575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N288_21590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N288_21605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N288_21620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
N288_21640	COG0740	serine-type endopeptidase activity
N288_21645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N288_21650	COG1481	regulation of sporulation
N288_21655	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N288_21660	COG1660	Displays ATPase and GTPase activities
N288_21665	COG1051	belongs to the nudix hydrolase family
N288_21670	COG0492	ferredoxin-NADP+ reductase activity
N288_21675	COG0457	Tetratricopeptide repeat
N288_21680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N288_21680	COG0140	phosphoribosyl-ATP diphosphatase activity
N288_21685	COG0107	imidazoleglycerol-phosphate synthase activity
N288_21690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N288_21695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N288_21700	COG0131	Imidazoleglycerol-phosphate dehydratase
N288_21705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N288_21710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N288_21715	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
N288_21720	COG0110	maltose O-acetyltransferase activity
N288_21730	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
N288_21740	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
N288_21745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N288_21750	COG0363	glucosamine-6-phosphate deaminase activity
N288_21770	COG1950	PFAM Membrane protein of
N288_21775	COG3595	metallopeptidase activity
N288_21790	COG2755	lipolytic protein G-D-S-L family
N288_21795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N288_21800	COG0556	nucleotide-excision repair
N288_21805	COG4897	Protein conserved in bacteria
N288_21815	COG1473	amidohydrolase
N288_21820	COG1464	Belongs to the NlpA lipoprotein family
N288_21825	COG2011	ABC-type metal ion transport system permease component
N288_21830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N288_21845	COG4191	Histidine kinase
N288_21850	COG0840	transmembrane signaling receptor activity
N288_21860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N288_21875	COG0673	inositol 2-dehydrogenase activity
N288_21880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N288_21885	COG3409	Peptidoglycan-binding domain 1 protein
N288_21885	COG0793	Belongs to the peptidase S41A family
N288_21890	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_21895	COG0791	NLP P60 protein
N288_21895	COG3883	PFAM NLP P60 protein
N288_21900	COG2177	Part of the ABC transporter FtsEX involved in
N288_21905	COG2884	Cell division ATP-binding protein ftsE
N288_21915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N288_21925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N288_21930	COG0653	protein targeting
N288_21950	COG1405	negative regulation of cell septum assembly
N288_21950	COG3012	SEC-C Motif Domain Protein
N288_21965	COG0840	transmembrane signaling receptor activity
N288_21970	COG2059	Chromate
N288_21975	COG2059	Chromate
N288_21980	COG4326	sporulation control protein
N288_22005	COG1516	flagellar protein fliS
N288_22010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N288_22010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N288_22015	COG1334	flagellar protein FlaG
N288_22020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N288_22020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N288_22030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N288_22035	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
N288_22045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N288_22050	COG1256	bacterial-type flagellum assembly
N288_22050	COG4786	Flagellar basal body rod
N288_22070	COG1040	competence protein
N288_22075	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
N288_22080	COG3328	transposase activity
N288_22100	COG1307	EDD domain protein, DegV family
N288_22115	COG2197	response regulator
N288_22120	COG4585	Histidine kinase
N288_22125	COG1739	Uncharacterized protein family UPF0029
N288_22130	COG1316	TRANSCRIPTIONal
N288_22150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N288_22155	COG0653	protein targeting
N288_22180	COG1696	Membrane protein involved in D-alanine export
N288_22245	COG0584	glycerophosphoryl diester phosphodiesterase
N288_22250	COG0584	glycerophosphoryl diester phosphodiesterase
N288_22265	COG3876	Protein conserved in bacteria
N288_22270	COG1472	Belongs to the glycosyl hydrolase 3 family
N288_22285	COG3853	Toxic anion resistance protein (TelA)
N288_22290	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
N288_22300	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N288_22315	COG2267	carboxylic ester hydrolase activity
N288_22320	COG0840	transmembrane signaling receptor activity
N288_22320	COG3290	protein histidine kinase activity
N288_22345	COG3584	3D domain protein
N288_22345	COG3583	domain protein
N288_22365	COG0366	Alpha amylase catalytic
N288_22370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N288_22375	COG0366	Alpha amylase catalytic
N288_22395	COG1609	Transcriptional regulator
N288_22410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N288_22415	COG1473	amidohydrolase
N288_22420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N288_22425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N288_22435	COG1028	Short-chain dehydrogenase reductase Sdr
N288_22440	COG1312	Catalyzes the dehydration of D-mannonate
N288_22445	COG0800	Aldolase
N288_22450	COG1063	alcohol dehydrogenase
N288_22455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N288_22465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N288_22470	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N288_22485	COG1609	Transcriptional regulator
N288_22490	COG0726	polysaccharide deacetylase
N288_22495	COG1215	transferase activity, transferring glycosyl groups
N288_22515	COG0366	Alpha amylase catalytic
N288_22535	COG5632	N-Acetylmuramoyl-L-alanine amidase
N288_22535	COG3409	Peptidoglycan-binding domain 1 protein
N288_22535	COG1388	LysM domain
N288_22550	COG0402	S-adenosylhomocysteine deaminase activity
N288_22555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N288_22560	COG1914	H( )-stimulated, divalent metal cation uptake system
N288_22570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N288_22585	COG1653	transport
N288_22590	COG0395	ABC-type sugar transport system, permease component
N288_22595	COG4209	transmembrane transport
N288_22600	COG5578	integral membrane protein
N288_22610	COG2188	Transcriptional regulator
N288_22625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N288_22640	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
N288_22665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N288_22670	COG2188	Transcriptional regulator
N288_22675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N288_22680	COG2222	sugar isomerase
N288_22685	COG0531	amino acid
N288_22690	COG1082	Xylose isomerase domain protein TIM barrel
N288_22705	COG0277	FAD linked oxidase domain protein
N288_22720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N288_22735	COG3732	PTS system glucitol sorbitol-specific
N288_22750	COG3711	transcriptional antiterminator
N288_22750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N288_22765	COG1940	carbohydrate kinase activity
N288_22770	COG2188	Transcriptional regulator
N288_22775	COG2723	6-phospho-beta-galactosidase activity
N288_22780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N288_22780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N288_22780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N288_22785	COG3711	transcriptional antiterminator
N288_22785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N288_22790	COG1482	cell wall glycoprotein biosynthetic process
N288_22805	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_22810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N288_22835	COG2723	6-phospho-beta-galactosidase activity
N288_22840	COG4753	response regulator
N288_22840	COG2207	Transcriptional regulator
N288_22840	COG4753	response regulator
N288_22840	COG2207	Transcriptional regulator
N288_22845	COG2972	Histidine kinase
N288_22855	COG1175	transmembrane transport
N288_22880	COG4821	SIS domain
N288_22885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N288_22890	COG0363	glucosamine-6-phosphate deaminase activity
N288_22930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N288_22945	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N288_22950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N288_22955	COG1609	Transcriptional regulator
N288_22960	COG0395	ABC-type sugar transport system, permease component
N288_22965	COG1175	transmembrane transport
N288_22970	COG1653	transport
N288_22975	COG0698	ribose 5-phosphate isomerase
N288_22990	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
N288_23000	COG3458	cephalosporin-C deacetylase activity
N288_23010	COG0383	alpha-mannosidase activity
N288_23020	COG0395	ABC-type sugar transport system, permease component
N288_23030	COG1653	transport
N288_23050	COG0395	ABC-type sugar transport system, permease component
N288_23065	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
N288_23075	COG2207	Transcriptional regulator
N288_23075	COG4753	response regulator
N288_23080	COG2972	Histidine kinase
N288_23085	COG5578	integral membrane protein
N288_23090	COG2304	oxidoreductase activity
N288_23185	COG2814	Major facilitator Superfamily
N288_23200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N288_23215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N288_23245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N288_23255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N288_23265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N288_23270	COG0673	inositol 2-dehydrogenase activity
N288_23295	COG0438	transferase activity, transferring glycosyl groups
N288_23305	COG0438	transferase activity, transferring glycosyl groups
N288_23305	COG0297	glycogen (starch) synthase activity
N288_23310	COG0438	transferase activity, transferring glycosyl groups
N288_23315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N288_23320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N288_23325	COG1086	Polysaccharide biosynthesis protein
N288_23330	COG4464	protein tyrosine phosphatase activity
N288_23335	COG0489	protein tyrosine kinase activity
N288_23340	COG3944	biosynthesis protein
N288_23350	COG2356	endonuclease I
N288_23355	COG0737	Belongs to the 5'-nucleotidase family
N288_23390	COG0438	transferase activity, transferring glycosyl groups
N288_23395	COG0728	peptidoglycan biosynthetic process
N288_23405	COG1595	DNA-templated transcription, initiation
N288_23425	COG4193	domain, Protein
N288_23425	COG5263	repeat protein
N288_23430	COG1388	LysM domain
N288_23430	COG0791	NLP P60 protein
N288_23435	COG1404	Belongs to the peptidase S8 family
N288_23460	COG0737	Belongs to the 5'-nucleotidase family
N288_23480	COG4715	Zinc finger, swim domain protein
N288_23485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N288_23510	COG0629	single-stranded DNA binding
N288_23540	COG4786	Flagellar basal body rod
N288_23545	COG4786	Flagellar basal body rod
N288_23555	COG1077	Cell shape determining protein MreB Mrl
N288_23565	COG1609	Transcriptional regulator
N288_23570	COG1388	LysM domain
N288_23570	COG0791	NLP P60 protein
N288_23575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N288_23590	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
N288_23600	COG0739	heme binding
N288_23610	COG2385	sporulation resulting in formation of a cellular spore
N288_23635	COG1007	ATP synthesis coupled electron transport
N288_23640	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N288_23645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N288_23650	COG0713	ATP synthesis coupled electron transport
N288_23655	COG0839	Belongs to the complex I subunit 6 family
N288_23660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N288_23665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N288_23670	COG0649	NAD binding
N288_23675	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N288_23680	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N288_23685	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N288_23690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N288_23695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N288_23700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N288_23710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N288_23715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N288_23720	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N288_23725	COG0356	it plays a direct role in the translocation of protons across the membrane
N288_23740	COG1404	Belongs to the peptidase S8 family
N288_23750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N288_23760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N288_23770	COG1595	DNA-templated transcription, initiation
N288_23780	COG0698	ribose 5-phosphate isomerase
N288_23785	COG0791	NLP P60 protein
N288_23795	COG0840	transmembrane signaling receptor activity
N288_23810	COG1971	Probably functions as a manganese efflux pump
N288_23815	COG0009	L-threonylcarbamoyladenylate synthase
N288_23835	COG2890	protein-(glutamine-N5) methyltransferase activity
N288_23840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N288_23855	COG1435	thymidine kinase activity
N288_23865	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N288_23875	COG1494	fructose-1,6-bisphosphatase
N288_23880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N288_23885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N288_23890	COG0191	fructose-bisphosphate aldolase activity
N288_23895	COG2204	response regulator
N288_23905	COG4821	SIS domain
N288_23915	COG3343	RNA polymerase activity
N288_23925	COG1703	isobutyryl-CoA mutase activity
N288_23925	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N288_23925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
N288_23935	COG1960	acyl-CoA dehydrogenase activity
N288_23940	COG1960	acyl-CoA dehydrogenase activity
N288_23945	COG1250	3-hydroxyacyl-CoA dehydrogenase
N288_23950	COG0183	Belongs to the thiolase family
N288_23955	COG0247	lactate metabolic process
N288_23955	COG2181	nitrate reductase activity
N288_23960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N288_23965	COG4294	response to UV
N288_23980	COG0018	arginyl-trna synthetase
N288_23985	COG4506	Protein conserved in bacteria
N288_23990	COG0010	Belongs to the arginase family
N288_24000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N288_24010	COG1994	Peptidase M50
N288_24020	COG3465	dGTPase activity
N288_24025	COG1078	dGTPase activity
N288_24030	COG4844	belongs to the
N288_24045	COG0280	phosphate acetyltransferase
N288_24060	COG3773	Cell wall hydrolase
N288_24070	COG2363	Small membrane protein
N288_24085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N288_24100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N288_24105	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N288_24110	COG0314	molybdopterin synthase activity
N288_24115	COG0746	molybdenum cofactor guanylyltransferase activity
N288_24135	COG0642	Histidine kinase
N288_24140	COG0745	RESPONSE REGULATOR receiver
N288_24145	COG0351	phosphomethylpyrimidine kinase
N288_24150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N288_24165	COG1131	(ABC) transporter
N288_24180	COG2133	pyrroloquinoline quinone binding
N288_24185	COG0561	phosphatase activity
N288_24215	COG1028	Short-chain dehydrogenase reductase Sdr
N288_24220	COG2031	fatty acid transporter
N288_24225	COG0789	Transcriptional regulator
N288_24230	COG1132	(ABC) transporter
N288_24260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N288_24265	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N288_24270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N288_24275	COG0366	Alpha amylase catalytic
N288_24285	COG2226	methyltransferase
N288_24290	COG0492	ferredoxin-NADP+ reductase activity
N288_24300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N288_24315	COG4187	Peptidase family M20/M25/M40
N288_24320	COG0346	lactoylglutathione lyase activity
N288_24330	COG2195	Cleaves the N-terminal amino acid of tripeptides
N288_24365	COG4211	Belongs to the binding-protein-dependent transport system permease family
N288_24370	COG1129	ABC transporter
N288_24385	COG2207	Transcriptional regulator
N288_24385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N288_24390	COG3275	phosphorelay sensor kinase activity
N288_24400	COG2207	Transcriptional regulator
N288_24400	COG4753	response regulator
N288_24435	COG2190	(PTS) system
N288_24435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N288_24435	COG1263	PTS System
N288_24445	COG0477	Major facilitator Superfamily
N288_24455	COG2080	2 iron, 2 sulfur cluster binding
N288_24465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N288_24470	COG2068	MobA-Related Protein
N288_24475	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
N288_24480	COG0745	RESPONSE REGULATOR receiver
N288_24485	COG0642	Histidine kinase
N288_24490	COG1136	(ABC) transporter
N288_24495	COG0577	efflux transmembrane transporter activity
N288_24500	COG1279	arginine transmembrane transporter activity
N288_24505	COG0450	alkyl hydroperoxide reductase
N288_24510	COG3634	alkyl hydroperoxide reductase activity
N288_24515	COG2814	Major facilitator Superfamily
N288_24520	COG1309	transcriptional regulator
N288_24540	COG0300	oxidoreductase activity
N288_24545	COG0640	Transcriptional regulator
N288_24560	COG2368	4-hydroxyphenylacetate
N288_24565	COG3739	integral membrane protein
N288_24570	COG3655	Transcriptional regulator
N288_24580	COG1028	Short-chain dehydrogenase reductase Sdr
N288_24590	COG0662	Cupin 2, conserved barrel domain protein
N288_24610	COG5577	PFAM Coat F domain
N288_24615	COG1063	alcohol dehydrogenase
N288_24625	COG5577	PFAM Coat F domain
N288_24630	COG0753	catalase activity
N288_24665	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
N288_24675	COG1683	Conserved Protein
N288_24685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N288_24700	COG0295	cytidine deaminase activity
N288_24715	COG2323	membrane
N288_24740	COG2188	Transcriptional regulator
N288_24745	COG1263	PTS System
N288_24745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N288_24750	COG1388	LysM domain
N288_24755	COG5002	protein histidine kinase activity
N288_24760	COG0745	RESPONSE REGULATOR receiver
N288_24790	COG3386	PFAM SMP-30 Gluconolaconase
N288_24815	COG1846	Transcriptional regulator
N288_24820	COG1380	Effector of murein hydrolase LrgA
N288_24825	COG1346	cytolysis
N288_24840	COG1131	(ABC) transporter
N288_24855	COG1266	CAAX protease self-immunity
N288_24860	COG0789	Transcriptional regulator
N288_24860	COG4978	Transcriptional regulator
N288_24880	COG0800	Aldolase
N288_24885	COG2190	(PTS) system
N288_24885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N288_24885	COG1263	PTS System
N288_24890	COG4948	Mandelate Racemase Muconate Lactonizing
N288_24895	COG2188	Transcriptional regulator
N288_24935	COG1720	tRNA m6t6A37 methyltransferase activity
N288_24955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N288_25020	COG3708	Transcriptional regulator
N288_25020	COG2207	Transcriptional regulator
N288_25040	COG0596	Alpha beta hydrolase
N288_25045	COG2808	Putative FMN-binding domain
N288_25050	COG0456	acetyltransferase
N288_25055	COG1846	Transcriptional regulator
N288_25085	COG1027	Aspartate ammonia-lyase
N288_25095	COG2807	transmembrane transport
N288_25105	COG1028	Short-chain dehydrogenase reductase Sdr
N288_25205	COG1329	Transcriptional regulator
N288_25210	COG0456	acetyltransferase
N288_25250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N288_25280	COG3290	protein histidine kinase activity
N288_25280	COG0840	transmembrane signaling receptor activity
N288_25295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N288_25300	COG0346	lactoylglutathione lyase activity
N288_25305	COG0431	NADPH-dependent FMN reductase
N288_25310	COG1846	Transcriptional regulator
N288_25345	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
N288_25350	COG1131	(ABC) transporter
N288_25365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N288_25380	COG5002	protein histidine kinase activity
N288_25380	COG3850	Histidine kinase
N288_25385	COG0745	RESPONSE REGULATOR receiver
N288_25405	COG2205	protein histidine kinase activity
N288_25475	COG2304	oxidoreductase activity
N288_25515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N288_25530	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N288_25550	COG1316	TRANSCRIPTIONal
N288_25560	COG3142	Participates in the control of copper homeostasis
N288_25575	COG1113	amino acid transport
N288_25580	COG1785	Belongs to the alkaline phosphatase family
N288_25590	COG2318	DinB family
N288_25600	COG0577	efflux transmembrane transporter activity
N288_25605	COG1136	(ABC) transporter
N288_25620	COG1366	Belongs to the anti-sigma-factor antagonist family
N288_25625	COG0697	spore germination
N288_25640	COG1126	abc transporter atp-binding protein
N288_25645	COG0765	amino acid transport
N288_25665	COG2113	Glycine betaine
N288_25670	COG4176	ABC-type proline glycine betaine transport system permease component
N288_25675	COG4175	Glycine betaine
N288_25675	COG0517	IMP dehydrogenase activity
N288_25680	COG1510	regulation of RNA biosynthetic process
N288_25690	COG3420	alginic acid biosynthetic process
N288_25705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N288_25710	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N288_25715	COG1120	ATPase activity
N288_25720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N288_25725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N288_25735	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
N288_25750	COG5609	conserved protein (DUF2294)
N288_25755	COG2427	Protein of unknown function (DUF1641)
N288_25760	COG3383	formate dehydrogenase (NAD+) activity
N288_25765	COG2116	formate transmembrane transporter activity
N288_25790	COG2223	nitrite transmembrane transporter activity
N288_25795	COG3279	Response regulator of the LytR AlgR family
N288_25800	COG3275	phosphorelay sensor kinase activity
N288_25805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N288_25815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N288_25825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N288_25830	COG4853	Protein conserved in bacteria
N288_25835	COG4863	YycH protein
N288_25840	COG5002	protein histidine kinase activity
N288_25845	COG0745	RESPONSE REGULATOR receiver
N288_25850	COG1196	nuclear chromosome segregation
N288_25850	COG0741	lytic transglycosylase activity
N288_25850	COG0739	heme binding
N288_25875	COG0577	efflux transmembrane transporter activity
N288_25875	COG1136	(ABC) transporter
N288_25880	COG1136	(ABC) transporter
N288_25885	COG5002	protein histidine kinase activity
N288_25885	COG3850	Histidine kinase
N288_25890	COG0745	RESPONSE REGULATOR receiver
N288_25905	COG0305	Participates in initiation and elongation during chromosome replication
N288_25910	COG0359	binds to the 23S rRNA
N288_25915	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
N288_25925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N288_25930	COG0629	single-stranded DNA binding
N288_25935	COG0360	Binds together with S18 to 16S ribosomal RNA
N288_25940	COG0438	transferase activity, transferring glycosyl groups
N288_25945	COG0671	phosphoesterase, PA-phosphatase related
N288_25950	COG0012	GTP binding
N288_25960	COG4481	Protein conserved in bacteria
N288_25965	COG0668	transmembrane transport
N288_25980	COG1475	DNA binding
N288_25985	COG1192	Involved in chromosome partitioning
N288_25995	COG1475	DNA binding
N288_26000	COG0357	Ribosomal RNA small subunit methyltransferase G
N288_26010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N288_26015	COG1847	R3H domain protein