locus-tag class description BIS30_00030 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BIS30_00045 ENOG4108RZ2 Glycoside hydrolase family 16 BIS30_00060 ENOG4108Z7R Chaperone CsaA BIS30_00065 ENOG4105FTV AraC Family Transcriptional Regulator BIS30_00070 ENOG4108HJF gCN5-related N-acetyltransferase BIS30_00095 ENOG4105D29 Helix-turn-helix type 11 domain protein BIS30_00105 ENOG4105KTU Transcriptional regulator, arsr family BIS30_00115 ENOG4108SJC Membrane BIS30_00135 ENOG4105ECK Fatty Acid Desaturase BIS30_00140 ENOG4108ZGX Histidine kinase BIS30_00145 ENOG4108S01 response regulator BIS30_00150 ENOG4107RUZ Sss sodium solute transporter superfamily BIS30_00155 ENOG41069ER domain protein BIS30_00160 ENOG4105C9U ATP-dependent DNA helicase RecQ BIS30_00165 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BIS30_00185 ENOG4105C26 Dehydrogenase BIS30_00190 ENOG4105EWU Squalene--hopene cyclase BIS30_00195 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BIS30_00200 ENOG4105C8J )-transporter BIS30_00205 ENOG4105C09 Bile acid BIS30_00210 ENOG4105C7S Dehydrogenase BIS30_00220 ENOG4107T89 von Willebrand factor, type A BIS30_00225 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BIS30_00235 ENOG4105K4H Nlp p60 protein BIS30_00240 ENOG41087PP glycosyltransferase MGT family BIS30_00250 ENOG4107QMU Mate efflux family protein BIS30_00255 ENOG4106SCS STAS domain BIS30_00275 ENOG4105FR1 rard protein BIS30_00290 ENOG41090U3 tautomerase BIS30_00305 ENOG4105FBA Phospholipase Carboxylesterase BIS30_00320 ENOG4105E1V na solute symporter BIS30_00340 ENOG4108VXD carboxy-peptidase BIS30_00345 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BIS30_00355 ENOG4106Z5R BIS30_00360 ENOG410841Q phosphoesterase PA-phosphatase related protein BIS30_00390 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BIS30_00395 ENOG4108TSC N-acetyltransferase BIS30_00400 ENOG4107S4Y M20 DapE family protein YgeY BIS30_00455 ENOG4107T32 3-phytase (EC 3.1.3.8) BIS30_00460 ENOG4105C5E polysaccharide biosynthesis protein BIS30_00465 ENOG4105E0X reductase BIS30_00470 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BIS30_00490 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BIS30_00495 ENOG41090WU lipolytic protein G-D-S-L family BIS30_00500 ENOG4108KF3 Electron transport protein SCO1 SenC BIS30_00515 ENOG4105C7B Threonine dehydratase BIS30_00525 ENOG4108UT2 hemolysin iii BIS30_00535 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BIS30_00555 ENOG4107YX5 Pfam:DUF548 BIS30_00560 ENOG4108Y6J UPF0403 protein BIS30_00565 ENOG4105C01 Dihydroxy-acid dehydratase BIS30_00580 ENOG4108V06 Glutathione peroxidase BIS30_00585 ENOG4105CVG Homoserine O-transsuccinylase BIS30_00625 ENOG41081VK Ribonuclease BIS30_00655 ENOG410890F Dynamin family BIS30_00665 ENOG41065KQ synthase BIS30_00670 ENOG4105C2W permease BIS30_00675 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BIS30_00680 ENOG4105CTD carboxy-peptidase BIS30_00685 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) BIS30_00690 ENOG4108UHU Aldolase BIS30_00700 ENOG4108M60 Transcriptional regulator BIS30_00710 ENOG4105CHR reductase BIS30_00715 ENOG4105DVT helicase BIS30_00725 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BIS30_00735 ENOG4108UKS UPF0398 protein BIS30_00750 ENOG4107X2U Inherit from COG: Exonuclease-like protein BIS30_00755 ENOG4108I5C dEAD DEAH box helicase BIS30_00805 ENOG4105BZ4 penicillin-binding protein BIS30_00815 ENOG4105CSM endonuclease III BIS30_00825 ENOG4105C5S asparaginyl-tRNA synthetase BIS30_00830 ENOG4105CHM Aminotransferase BIS30_00840 ENOG4105YAC BIS30_00845 ENOG4105DVT helicase BIS30_00850 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BIS30_00855 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BIS30_00860 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BIS30_00870 ENOG4105DJ0 Poly(A) Polymerase BIS30_00875 ENOG4105CPK Glycosyl transferase (Group 1 BIS30_00880 ENOG4105FJR Lmbe family BIS30_00885 ENOG4108Z5K methylglyoxal synthase BIS30_00890 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BIS30_00895 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BIS30_00900 ENOG4108JYZ YitT family BIS30_00920 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BIS30_00940 ENOG41068YB TPR repeat-containing protein BIS30_00945 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BIS30_00955 ENOG4105CIH Imidazole acetol-phosphate transaminase BIS30_00965 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BIS30_00970 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BIS30_00980 ENOG4108I0Q anthranilate phosphoribosyltransferase BIS30_00985 ENOG4105CRQ synthase (Component I) BIS30_00990 ENOG4105KHN chorismate mutase BIS30_00995 ENOG4105D49 3-dehydroquinate synthase BIS30_01000 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BIS30_01005 ENOG4105BZU Histidine kinase BIS30_01015 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BIS30_01020 ENOG4105EAH synthase BIS30_01025 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BIS30_01030 ENOG4105XXQ heptaprenyl diphosphate synthase component I BIS30_01040 ENOG4105EUJ GTP cyclohydrolase i BIS30_01045 ENOG4105K70 DNA-binding protein BIS30_01050 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BIS30_01065 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BIS30_01070 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BIS30_01075 ENOG41065D1 BIS30_01080 ENOG4105S2F BIS30_01095 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BIS30_01100 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BIS30_01105 ENOG4105CAT Cytidine monophosphate kinase BIS30_01120 ENOG4105MSI germination protein ypeb BIS30_01130 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BIS30_01135 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BIS30_01150 ENOG4107RGJ metallophosphoesterase BIS30_01165 ENOG4105I7S Abortive infection protein BIS30_01170 ENOG4105C9U ATP-dependent DNA helicase RecQ BIS30_01175 ENOG4105T7X BIS30_01185 ENOG4108SAX Membrane BIS30_01195 ENOG4108JQ1 Dehydrogenase BIS30_01200 ENOG4105FF2 Type I DHQase BIS30_01215 ENOG4105BZU Histidine kinase BIS30_01220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BIS30_01225 ENOG4105CRE cytochrome C BIS30_01240 ENOG4105FE9 pseudouridine synthase BIS30_01250 ENOG4108JIC nucleoside recognition domain protein BIS30_01255 ENOG4105DZ1 carboxypeptidase BIS30_01265 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BIS30_01270 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BIS30_01285 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BIS30_01290 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BIS30_01295 ENOG4108R6K riboflavin synthase, subunit alpha BIS30_01300 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BIS30_01310 ENOG4105C3F Signal peptidase i BIS30_01315 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) BIS30_01325 ENOG4107ZE5 PPIases accelerate the folding of proteins BIS30_01335 ENOG4105PTM secreted protein BIS30_01340 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BIS30_01350 ENOG4105G6R Stage v sporulation protein ae BIS30_01360 ENOG4105CZ3 stage V sporulation protein ad BIS30_01365 ENOG41090VF Stage v sporulation protein ac BIS30_01380 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIS30_01385 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BIS30_01390 ENOG41082AN stage II sporulation protein BIS30_01395 ENOG4105DZ1 carboxypeptidase BIS30_01400 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BIS30_01405 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BIS30_01410 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BIS30_01420 ENOG4105I3K Ferric uptake regulator, Fur family BIS30_01425 ENOG4105MZ9 stage II sporulation protein m BIS30_01440 ENOG4105DFD Na H antiporter BIS30_01445 ENOG4108IJ0 Aspartate ammonia-lyase BIS30_01450 ENOG4105HDK L-asparaginase BIS30_01455 ENOG4108IMY Transcriptional regulator BIS30_01465 ENOG4105DQ6 Transposase BIS30_01475 ENOG4108YZ4 nudix hydrolase BIS30_01500 ENOG4105CNI cell division protein FtsW BIS30_01505 ENOG4105CNI cell division protein FtsW BIS30_01520 ENOG4106HZJ BIS30_01525 ENOG4105RHY Pfam:UPF0157 BIS30_01530 ENOG4105KAC Antibiotic biosynthesis monooxygenase BIS30_01535 ENOG4108XET gCN5-related N-acetyltransferase BIS30_01545 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BIS30_01560 ENOG4105E5W Transporter BIS30_01570 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BIS30_01585 ENOG4108IXY short-chain dehydrogenase reductase BIS30_01590 ENOG41069FQ Metallo-beta-lactamase superfamily BIS30_01595 ENOG4105II7 pyrroline-5-carboxylate reductase BIS30_01605 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BIS30_01625 ENOG410861F 50S ribosomal protein L33 BIS30_01630 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BIS30_01635 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BIS30_01640 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BIS30_01645 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BIS30_01655 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BIS30_01660 ENOG4108NA0 Uncharacterized conserved protein (COG2071) BIS30_01665 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BIS30_01675 ENOG4108ZVT methylmalonyl-coA epimerase BIS30_01685 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BIS30_01690 ENOG4108QEG Membrane BIS30_01695 ENOG4105CDA abc transporter atp-binding protein BIS30_01700 ENOG4105E5Q amino acid AbC transporter BIS30_01705 ENOG4108HW3 (ABC) transporter BIS30_01710 ENOG4108Y6J UPF0403 protein BIS30_01715 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BIS30_01730 ENOG4105C7S Dehydrogenase BIS30_01735 ENOG4105CPP Dehydrogenase, E1 component BIS30_01750 ENOG4105CKM Branched-chain carboxylic acid kinase BIS30_01755 ENOG4107RDP Dehydrogenase BIS30_01765 ENOG4108JUB Transcriptional regulator BIS30_01770 ENOG4106CCJ Protein of unknown function (DUF2627) BIS30_01775 ENOG4105CR4 methylisocitrate lyase BIS30_01780 ENOG4105DXD 2-methylcitrate dehydratase BIS30_01790 ENOG4105C1G acyl-Coa dehydrogenase BIS30_01795 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BIS30_01805 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BIS30_01810 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BIS30_01825 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BIS30_01835 ENOG4107QQR Sporulation BIS30_01845 ENOG4105S1Z Stage IV sporulation protein B BIS30_01850 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BIS30_01855 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BIS30_01860 ENOG4105DX0 Hemolysin A BIS30_01870 ENOG4105CTB Polyprenyl synthetase BIS30_01875 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BIS30_01880 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BIS30_01890 ENOG4105M7K Involved in the transcription termination process (By similarity) BIS30_01895 ENOG4108ZSR alkaline shock protein BIS30_01920 ENOG410644B Stage III sporulation protein af BIS30_01930 ENOG4105KQ4 Stage iii sporulation protein ad BIS30_01935 ENOG4108CQH stage III sporulation protein AC BIS30_01940 ENOG4105KR5 Stage iii sporulation protein BIS30_01945 ENOG4105CD2 stage iii sporulation protein aa BIS30_01955 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BIS30_01960 ENOG4105DC7 peptidase M24 BIS30_01965 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BIS30_01975 ENOG4105CBJ Metal-dependent enzyme BIS30_01990 ENOG4105KST dependent repressor BIS30_01995 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BIS30_02000 ENOG4105WZW rhodanese family BIS30_02005 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BIS30_02010 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BIS30_02015 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BIS30_02020 ENOG4105C0D helicase BIS30_02035 ENOG4108IMY Transcriptional regulator BIS30_02045 ENOG4105VFR signal peptidase BIS30_02100 ENOG41080XP Cbs domain BIS30_02135 ENOG4105C5X domain protein BIS30_02160 ENOG4105E0M Sulfatase BIS30_02175 ENOG4107ZXI Rhomboid family BIS30_02185 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BIS30_02190 ENOG4105WDJ 50S ribosomal protein L33 BIS30_02210 ENOG41068DG YceG-like family BIS30_02215 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BIS30_02220 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BIS30_02225 ENOG4105E2Z phosphate ABC transporter (Permease BIS30_02230 ENOG4105C8U phosphate abc transporter BIS30_02235 ENOG4105CVA phosphate BIS30_02240 ENOG4107RF6 penicillin-binding protein BIS30_02250 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BIS30_02255 ENOG4105SXS Protein of unknown function (DUF456) BIS30_02275 ENOG41063Y9 BIS30_02280 ENOG4108U5J '-nucleotidase BIS30_02285 ENOG4105N80 Ferric uptake regulator, Fur family BIS30_02290 ENOG4108JYZ YitT family BIS30_02295 ENOG41069ZM Protein of unknown function (DUF2624) BIS30_02300 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BIS30_02315 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BIS30_02320 ENOG4105EGD dinuclear metal center protein, YbgI family BIS30_02335 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIS30_02340 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BIS30_02345 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 BIS30_02350 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BIS30_02360 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BIS30_02365 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BIS30_02370 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BIS30_02380 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BIS30_02385 ENOG4105KG3 cytidine deaminase BIS30_02390 ENOG4107YR5 Diacylglycerol kinase BIS30_02395 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BIS30_02400 ENOG4105CTJ Metal Dependent Phosphohydrolase BIS30_02410 ENOG4105C9A Phoh family BIS30_02415 ENOG4105EI1 sporulation protein yqfd BIS30_02420 ENOG41068P3 sporulation protein YqfC BIS30_02430 ENOG4105DI5 UPF0365 protein BIS30_02435 ENOG4105F7J membrane-bound serine protease BIS30_02440 ENOG4105KTH gatB Yqey BIS30_02455 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BIS30_02460 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BIS30_02465 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BIS30_02475 ENOG4105CFG Acts as a chaperone (By similarity) BIS30_02480 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BIS30_02485 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BIS30_02490 ENOG4105CSA Coproporphyrinogen iii oxidase BIS30_02495 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BIS30_02505 ENOG4108ZRV stage ii sporulation protein p BIS30_02510 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BIS30_02515 ENOG41082YS Binds directly to 16S ribosomal RNA BIS30_02520 ENOG4105TQK DNA polymerase iii, delta' subunit BIS30_02530 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BIS30_02535 ENOG4108UK2 deaminase BIS30_02540 ENOG4105KQC Competence protein BIS30_02550 ENOG4108D32 Methyltransferase BIS30_02560 ENOG4108WF2 Metal Dependent Phosphohydrolase BIS30_02565 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BIS30_02570 ENOG410812S Rna-binding protein BIS30_02575 ENOG4105E2X shikimate dehydrogenase BIS30_02580 ENOG4105CQW ribosome biogenesis GTPase YqeH BIS30_02585 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BIS30_02610 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BIS30_02615 ENOG41080BT SNARE associated Golgi BIS30_02630 ENOG4105WFK nuclease BIS30_02635 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIS30_02640 ENOG4107Y5K Resolvase BIS30_02645 ENOG4105C9Q fumarate hydratase class II BIS30_02650 ENOG4107RSM transcriptional regulator BIS30_02670 ENOG4105EA8 2-Nitropropane dioxygenase BIS30_02675 ENOG4105K56 Transcriptional regulator BIS30_02685 ENOG4105KVH Transcriptional regulator BIS30_02690 ENOG4108DBC nitroreductase BIS30_02695 ENOG4108R6W Transcriptional regulator, ARAC family BIS30_02705 ENOG4105EMU Dehydrogenase BIS30_02715 ENOG41090E6 transcriptional regulator MERR family BIS30_02725 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BIS30_02735 ENOG41073TP transcriptional regulator BIS30_02740 ENOG4105CTQ phosphohexokinase BIS30_02755 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BIS30_02760 ENOG4108HHA Transketolase BIS30_02775 ENOG4105WAB arsR family transcriptional regulator BIS30_02780 ENOG4105BZG amino acid carrier protein BIS30_02785 ENOG4105UNS Pfam:DUF419 BIS30_02800 ENOG4108MEK Metal-binding protein YodA BIS30_02805 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein BIS30_02810 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein BIS30_02820 ENOG4105PGS Spore coat protein BIS30_02825 ENOG4105E2A Dehydrogenase BIS30_02840 ENOG4105KRI phosphocarrier protein (HPr BIS30_02845 ENOG4105CPC Aldo Keto reductase BIS30_02850 ENOG4105CF7 AraC family transcriptional regulator BIS30_02855 ENOG4105VUF Transcriptional regulator BIS30_02860 ENOG4105VUF Transcriptional regulator BIS30_02865 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BIS30_02870 ENOG4105DQ4 alcohol dehydrogenase BIS30_02875 ENOG4108Z0Z intracellular protease Pfpi family BIS30_02880 ENOG4108HKT sucrose-6-phosphate hydrolase BIS30_02885 ENOG4105F3R pts system mannose fructose sorbose family iid BIS30_02890 ENOG4105ETZ PTS System BIS30_02895 ENOG4108IQ3 PTS system BIS30_02900 ENOG4105YHU PTS system BIS30_02905 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BIS30_02920 ENOG4105C85 amino acid BIS30_02925 ENOG4105N14 lysine exporter protein LysE YggA BIS30_02930 ENOG4108NGU Transcriptional regulator BIS30_02935 ENOG4105JVQ RNA Polymerase BIS30_02940 ENOG4108P49 AntiSigma factor BIS30_02945 ENOG4105EXC Acyl-transferase BIS30_02950 ENOG4105WDR BIS30_02955 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BIS30_02960 ENOG41082JN Transcriptional regulator BIS30_02985 ENOG4105TMB Formate nitrite transporter BIS30_02990 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BIS30_02995 ENOG4108JB9 formate dehydrogenase BIS30_03010 ENOG4105C28 cystathionine BIS30_03025 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BIS30_03040 ENOG4107XRG penicillin-binding protein BIS30_03045 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BIS30_03050 ENOG4105DBI uridine monophosphokinase BIS30_03055 ENOG4105CFP Peptidase U32 BIS30_03060 ENOG4105XYU peptidase (U32 family) BIS30_03065 ENOG4108VQJ O-methyltransferase BIS30_03070 ENOG4105HHA aminodeoxychorismate lyase BIS30_03075 ENOG4105VPH UPF0473 protein BIS30_03080 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BIS30_03085 ENOG4105VBH UPF0297 protein BIS30_03090 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BIS30_03095 ENOG4105C02 permease BIS30_03105 ENOG41060CR BIS30_03115 ENOG4105C7H Helicase, RecD TraA family BIS30_03125 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BIS30_03130 ENOG4105C3J Cysteine desulfurase BIS30_03140 ENOG4105D1H recombination factor protein RarA BIS30_03155 ENOG4105CUZ uba thif-type nad fad binding protein BIS30_03165 ENOG4105C9M aspartyl-trna synthetase BIS30_03170 ENOG4105CUT histidyl-tRNA synthetase BIS30_03185 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BIS30_03195 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BIS30_03200 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BIS30_03205 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BIS30_03210 ENOG41067VP Protein of unknown function (DUF1049) BIS30_03215 ENOG4105NCW Trka-c domain protein BIS30_03220 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BIS30_03230 ENOG4105CKP Polysaccharide Biosynthesis Protein BIS30_03235 ENOG4108QG2 Membrane BIS30_03240 ENOG4105NAP BIS30_03245 ENOG4105VIE preprotein translocase, subunit YajC BIS30_03250 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BIS30_03255 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BIS30_03260 ENOG41061AI Protein of unknown function (DUF2905) BIS30_03265 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BIS30_03270 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BIS30_03280 ENOG4105IE8 Alpha-ketoglutarate permease BIS30_03285 ENOG4105CK5 oxidoreductase BIS30_03300 ENOG4105BZG amino acid carrier protein BIS30_03305 ENOG4105CDY transcriptional regulatory protein BIS30_03315 ENOG4106678 morphogenetic protein associated with SpoVID BIS30_03345 ENOG4105CQC Prephenate dehydratase BIS30_03350 ENOG41090I5 UPF0735 ACT domain-containing protein BIS30_03355 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BIS30_03370 ENOG4105K46 50S ribosomal protein l27 BIS30_03375 ENOG4105X36 (ribosomal) protein BIS30_03380 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BIS30_03395 ENOG4107QMS site-determining protein BIS30_03400 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BIS30_03405 ENOG4105YHC Rod shape-determining protein MreD BIS30_03410 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BIS30_03415 ENOG4105DFF Rod shape-determining protein mreb BIS30_03420 ENOG4105W5Q DNA repair protein (RadC BIS30_03425 ENOG4108Z03 MAF-like protein BIS30_03435 ENOG4106A3R peptidase BIS30_03440 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BIS30_03445 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BIS30_03455 ENOG4106AR7 Spore coat protein BIS30_03460 ENOG41068KH stage VI sporulation protein D BIS30_03465 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BIS30_03470 ENOG4105D52 delta-aminolevulinic acid dehydratase BIS30_03480 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BIS30_03490 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BIS30_03500 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BIS30_03505 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BIS30_03510 ENOG4108IUQ atp-dependent protease BIS30_03520 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BIS30_03530 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BIS30_03535 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BIS30_03540 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BIS30_03550 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BIS30_03555 ENOG4108ZP8 Acetolactate synthase small subunit BIS30_03560 ENOG4105C7K acetolactate synthase BIS30_03570 ENOG4105I4A GCN5-related N-acetyltransferase BIS30_03580 ENOG4107KM7 Heat induced stress protein YflT BIS30_03590 ENOG4105M59 Phosphodiesterase, mj0936 family BIS30_03595 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BIS30_03600 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BIS30_03605 ENOG4108XJQ germination protein BIS30_03610 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BIS30_03615 ENOG41067TZ transcriptional regulator, MarR family BIS30_03620 ENOG4105PFC Transcriptional regulator BIS30_03630 ENOG4105E33 succinate dehydrogenase BIS30_03640 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BIS30_03655 ENOG4105CFH Aspartokinase BIS30_03660 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BIS30_03665 ENOG4105K63 Thioredoxin BIS30_03670 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BIS30_03675 ENOG4105C10 Electron transfer flavoprotein BIS30_03680 ENOG4105BZJ Electron transfer flavoprotein BIS30_03685 ENOG41060WC Enoyl-CoA hydratase BIS30_03690 ENOG4107Z3H Transcriptional regulator, TetR family BIS30_03695 ENOG4105CEY Amp-dependent synthetase and ligase BIS30_03705 ENOG4105C98 muts2 protein BIS30_03725 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BIS30_03730 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BIS30_03735 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BIS30_03740 ENOG4108RWN rrna methyltransferase BIS30_03745 ENOG41067MF small acid-soluble spore protein BIS30_03750 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BIS30_03755 ENOG4105CQB FAD linked oxidase domain protein BIS30_03760 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BIS30_03785 ENOG4105K7K Transcriptional regulator BIS30_03790 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BIS30_03795 ENOG4105DRS transport system, permease BIS30_03810 ENOG4108MDK Dehydrogenase BIS30_03820 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BIS30_03825 ENOG4105EF1 ribulokinase BIS30_03835 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase BIS30_03840 ENOG4105CN9 Peptidase m42 family protein BIS30_03850 ENOG410696E Membrane BIS30_03855 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BIS30_03860 ENOG4105VJV 50s ribosomal protein L35 BIS30_03865 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BIS30_03880 ENOG41067MG lrgb family BIS30_03900 ENOG4105U0R haloacid dehalogenase-like hydrolase BIS30_03905 ENOG4105C22 threonyL-tRNA synthetase BIS30_03910 ENOG4108TDW sporulation protein YtxC BIS30_03930 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BIS30_03935 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BIS30_03940 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BIS30_03945 ENOG4105KVH Transcriptional regulator BIS30_03950 ENOG4105F27 Major Facilitator BIS30_03955 ENOG4105CV8 reductase BIS30_03960 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BIS30_03975 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BIS30_03980 ENOG4105C2M dna polymerase I BIS30_03985 ENOG4105BZU Histidine kinase BIS30_03990 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BIS30_03995 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BIS30_04000 ENOG4108HMX isocitrate dehydrogenase (NADP) BIS30_04005 ENOG4105BZN citrate synthase BIS30_04015 ENOG4108REF Sporulation integral membrane protein ytvi BIS30_04020 ENOG4105FS0 cytoplasmic membrane protein BIS30_04025 ENOG4105CA9 Pyruvate kinase BIS30_04030 ENOG4105CTQ phosphohexokinase BIS30_04040 ENOG4108IEY Carboxyl transferase domain BIS30_04045 ENOG4105C6K Malic enzyme BIS30_04050 ENOG4105C0B DNA polymerase III (alpha subunit) BIS30_04055 ENOG4105VV2 BIS30_04065 ENOG4106EVM BIS30_04070 ENOG4105SFS phosphoesterase RecJ domain protein BIS30_04085 ENOG4105E8R UPF0173 metal-dependent hydrolase BIS30_04100 ENOG4105CH7 arginosuccinase BIS30_04105 ENOG4105CDH Citrulline--aspartate ligase BIS30_04110 ENOG4105EPU Molybdenum cofactor synthesis domain protein BIS30_04115 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BIS30_04125 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BIS30_04130 ENOG4105KBJ sporulation protein ytfj BIS30_04140 ENOG4105VK3 rdd domain containing protein BIS30_04145 ENOG4105D07 Signal peptide peptidase, SppA BIS30_04150 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BIS30_04155 ENOG4105EFZ amidohydrolase BIS30_04160 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BIS30_04195 ENOG4105U5Y Transcriptional regulator BIS30_04205 ENOG4105BZU Histidine kinase BIS30_04210 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BIS30_04220 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BIS30_04230 ENOG4105F1V Acetoin utilization protein BIS30_04235 ENOG4105W87 Cbs domain BIS30_04240 ENOG4105DGU Histone deacetylase BIS30_04245 ENOG4105ER2 Ompa motb domain protein BIS30_04250 ENOG4107R0U MotA TolQ exbB proton channel BIS30_04255 ENOG4105ETE Transcriptional regulator (LacI family BIS30_04260 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BIS30_04280 ENOG4105DFU Cell wall formation (By similarity) BIS30_04290 ENOG4108VDD TRNA binding domain protein BIS30_04305 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BIS30_04320 ENOG4105C6K Malic enzyme BIS30_04325 ENOG4105C8F Beta-lactamase domain protein BIS30_04330 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BIS30_04340 ENOG4108V15 phosphotransferase enzyme family BIS30_04345 ENOG4108IUM Glycogen debranching enzyme BIS30_04360 ENOG4107F58 2'-5' rna ligase BIS30_04365 ENOG4105C6T cysteine synthase BIS30_04370 ENOG4107QSE Dipeptidase BIS30_04375 ENOG4105C7N Xanthine uracil vitamin C permease BIS30_04390 ENOG4105YW5 deoR family transcriptional regulator BIS30_04405 ENOG4105CBX hi0933 family BIS30_04410 ENOG4105C94 Transporter BIS30_04420 ENOG4105MU9 integral membrane protein BIS30_04425 ENOG4105DDC Oxidoreductase domain protein BIS30_04435 ENOG4105F5H Glycosyl Hydrolase Family 88 BIS30_04445 ENOG41075H3 AraC family transcriptional regulator BIS30_04455 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BIS30_04465 ENOG4106A3M Cytochrome p-450 BIS30_04470 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BIS30_04480 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BIS30_04485 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BIS30_04500 ENOG4105NTD Inherit from COG: Hydrolase BIS30_04515 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BIS30_04520 ENOG4105I1K ABC transporter BIS30_04530 ENOG41085GJ domain protein BIS30_04535 ENOG4105C8T Leucyl-tRNA synthetase BIS30_04545 ENOG4105BZU Histidine kinase BIS30_04550 ENOG410605W Major Facilitator BIS30_04555 ENOG4106UBQ BIS30_04565 ENOG4105C19 ABC transporter BIS30_04570 ENOG4105EWM Histidine kinase BIS30_04585 ENOG4105C19 ABC transporter BIS30_04600 ENOG4105DVE abc transporter atp-binding protein BIS30_04605 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BIS30_04620 ENOG4105N5T Radical SAM Protein BIS30_04635 ENOG4105E8V Alpha Beta Hydrolase Fold protein BIS30_04640 ENOG4108Z0R Transferase BIS30_04645 ENOG4105C85 amino acid BIS30_04655 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BIS30_04660 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BIS30_04675 ENOG4105D2X ABC transporter substrate-binding protein BIS30_04685 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BIS30_04690 ENOG4105DQ6 Transposase BIS30_04710 ENOG4108RMU ferritin dps family protein BIS30_04725 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BIS30_04730 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BIS30_04735 ENOG4108V2W Carbonate dehydratase BIS30_04760 ENOG4105CC5 ABC transporter BIS30_04765 ENOG4105CC5 ABC transporter BIS30_04770 ENOG4105DIK (ABC) transporter BIS30_04775 ENOG4105DSE periplasmic solute binding protein BIS30_04780 ENOG4105DTQ mandelate racemase muconate lactonizing BIS30_04785 ENOG4105CEY Amp-dependent synthetase and ligase BIS30_04790 ENOG4108IPT Naphthoate synthase BIS30_04795 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BIS30_04800 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BIS30_04805 ENOG4105E4F Isochorismate synthase BIS30_04825 ENOG4108IAJ Nad-dependent epimerase dehydratase BIS30_04830 ENOG4107SBE Glycosyl transferase (Group 1 BIS30_04845 ENOG4107SBE Glycosyl transferase (Group 1 BIS30_04850 ENOG4108KS4 Spore coat protein BIS30_04865 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BIS30_04875 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BIS30_05010 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BIS30_05015 ENOG4105VRR gCN5-related N-acetyltransferase BIS30_05020 ENOG4105DZ6 Band 7 protein BIS30_05030 ENOG4106DF1 BIS30_05035 ENOG4108VNY MOSC domain protein BIS30_05040 ENOG4108JB8 alcohol dehydrogenase BIS30_05045 ENOG4105C26 Dehydrogenase BIS30_05050 ENOG4105TRT Transcriptional regulator BIS30_05065 ENOG4105CZN Potassium uptake protein BIS30_05070 ENOG4107I77 yiaA/B two helix domain BIS30_05075 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BIS30_05095 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BIS30_05105 ENOG4105EE0 oxidoreductase BIS30_05110 ENOG4105DKG l-rhamnose isomerase BIS30_05115 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) BIS30_05120 ENOG4105DET Rhamnulokinase BIS30_05125 ENOG4105E98 transcriptional regulator DeoR family BIS30_05135 ENOG4105C8Q Methyl-accepting chemotaxis BIS30_05140 ENOG4105C8Q Methyl-accepting chemotaxis BIS30_05145 ENOG4105C8Q Methyl-accepting chemotaxis BIS30_05150 ENOG4105C8Q Methyl-accepting chemotaxis BIS30_05165 ENOG4105EA8 2-Nitropropane dioxygenase BIS30_05170 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BIS30_05185 ENOG4105DQ6 Transposase BIS30_05190 ENOG4105C37 (CBS) domain BIS30_05205 ENOG4107PBV potassium channel BIS30_05210 ENOG4107PBV potassium channel BIS30_05225 ENOG4107QYV phosphohexose isomerase BIS30_05235 ENOG4107QW4 alcohol dehydrogenase BIS30_05240 ENOG4105WG9 Conserved Protein BIS30_05250 ENOG4105CHM Aminotransferase BIS30_05255 ENOG4108ZB6 transcriptional regulator AsnC family BIS30_05260 ENOG4108MUZ hydrolase BIS30_05270 ENOG4105C87 Aminotransferase class I and II BIS30_05275 ENOG4108HGU Histidine kinase BIS30_05280 ENOG4105Y38 Kinase-associated protein B BIS30_05300 ENOG4105BZ4 penicillin-binding protein BIS30_05305 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BIS30_05320 ENOG4108MRH transcriptional regulatory protein BIS30_05335 ENOG4105D65 subunit l BIS30_05340 ENOG4105HC0 Na H antiporter BIS30_05345 ENOG4108ZE9 Monovalent cation H antiporter subunit C BIS30_05350 ENOG4108JPZ Monovalent cation H antiporter subunit D BIS30_05365 ENOG4105KJM monovalent cation h antiporter subunit g BIS30_05370 ENOG4105KA0 thioesterase Superfamily protein BIS30_05380 ENOG4105BZU Histidine kinase BIS30_05405 ENOG4105D58 Diguanylate phosphodiesterase BIS30_05410 ENOG4105DAP Nicotinate phosphoribosyltransferase BIS30_05435 ENOG4105C02 permease BIS30_05455 ENOG410904N short-chain dehydrogenase reductase BIS30_05490 ENOG4108K8K Transcriptional regulator BIS30_05495 ENOG4105DCF alanine dehydrogenase BIS30_05505 ENOG4105WQT MbtH domain protein BIS30_05510 ENOG4105CEY Amp-dependent synthetase and ligase BIS30_05515 ENOG4105WQI isochorismatase BIS30_05520 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BIS30_05525 ENOG4105E4F Isochorismate synthase BIS30_05530 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BIS30_05535 ENOG4105NIV Esterase BIS30_05555 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BIS30_05565 ENOG41069ER domain protein BIS30_05580 ENOG4105CEP NADH dehydrogenase BIS30_05585 ENOG4105CAY ferredoxin--nadp reductase BIS30_05610 ENOG4105CJ1 ABC, transporter BIS30_05630 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BIS30_05640 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BIS30_05655 ENOG4105ZKE UPF0349 protein BIS30_05670 ENOG41083MR nifu domain-containing protein BIS30_05675 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BIS30_05680 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BIS30_05685 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BIS30_05690 ENOG4105D6E homoserine dehydrogenase BIS30_05700 ENOG4108W5N phosphatidylglycerophosphatase a BIS30_05705 ENOG4105D4U had-superfamily hydrolase, subfamily iia BIS30_05715 ENOG4105MMD transcriptional regulator BIS30_05720 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BIS30_05725 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BIS30_05730 ENOG4105FAA peptidase M23 BIS30_05735 ENOG4108YTE sporulation protein YunB BIS30_05740 ENOG4105KZD Domain of unknown function (DUF1805) BIS30_05745 ENOG4107R8B 5'-nucleotidase BIS30_05755 ENOG4105I3N Conserved Protein BIS30_05765 ENOG4105CD3 dihydroorotase BIS30_05770 ENOG4105G9B Transcriptional regulator BIS30_05785 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) BIS30_05790 ENOG4105VT2 5-hydroxyisourate hydrolase BIS30_05805 ENOG4107YV9 domain protein BIS30_05810 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BIS30_05825 ENOG4105XRQ Xanthine dehydrogenase accessory factor BIS30_05830 ENOG4105C5R Aminotransferase BIS30_05850 ENOG4108K8S endonuclease I BIS30_05855 ENOG4108IJ9 (ABC) transporter BIS30_05865 ENOG4108KPW sugar kinase BIS30_05870 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BIS30_05875 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BIS30_05880 ENOG4105XN3 extracellular solute-binding protein family 1 BIS30_05885 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine BIS30_05890 ENOG4105PKS Excinuclease abc c subunit domain protein BIS30_05895 ENOG4107VFR oxidoreductase BIS30_05910 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BIS30_05915 ENOG4105NPE arsR family transcriptional regulator BIS30_05920 ENOG4105DIW FeS assembly protein SUFB BIS30_05925 ENOG4108UNV SUF system FeS assembly protein, NifU family BIS30_05930 ENOG4105C9B Cysteine desulfurase BIS30_05935 ENOG4105JRK feS assembly protein SufD BIS30_05940 ENOG4105C3K feS assembly ATPase SufC BIS30_05960 ENOG4105D01 (LipO)protein BIS30_05965 ENOG4108UMI ABC transporter, permease BIS30_05970 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BIS30_05995 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BIS30_06000 ENOG41080E8 Transcriptional regulator, Spx MgsR family BIS30_06005 ENOG4105C1G acyl-Coa dehydrogenase BIS30_06010 ENOG4105CHU acetyl-coa acetyltransferase BIS30_06040 ENOG41067TZ transcriptional regulator, MarR family BIS30_06045 ENOG4105C0R drug resistance transporter emrb qaca subfamily BIS30_06050 ENOG4105MDS 4-oxalocrotonate tautomerase BIS30_06060 ENOG4105EGI Transcriptional regulator BIS30_06070 ENOG4105E0A ABC, transporter BIS30_06085 ENOG4105E1F short-chain dehydrogenase reductase BIS30_06090 ENOG4105HUF DNA protection during starvation protein BIS30_06095 ENOG4105C0H protease BIS30_06105 ENOG4105F3H Histidine kinase BIS30_06115 ENOG41067SE Tetr family transcriptional regulator BIS30_06120 ENOG4105C9Q fumarate hydratase class II BIS30_06145 ENOG4105WH1 Two component transcriptional regulator luxr family BIS30_06150 ENOG4105ENE Histidine kinase BIS30_06165 ENOG41087YS Phage shock protein A BIS30_06180 ENOG4108WBT adenosyltransferase BIS30_06185 ENOG4105E0A ABC, transporter BIS30_06190 ENOG4105EHG Permease protein BIS30_06195 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BIS30_06205 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BIS30_06210 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BIS30_06220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BIS30_06230 ENOG4106DF4 Sigma-70, region 4 BIS30_06240 ENOG4105F0F Oxalate decarboxylase BIS30_06250 ENOG4107RBB ABC transporter, permease BIS30_06260 ENOG4108WMK Efflux transporter RND family MFP subunit BIS30_06265 ENOG4105E0A ABC, transporter BIS30_06270 ENOG4105EHG Permease protein BIS30_06275 ENOG4105DQ5 transport system permease protein BIS30_06290 ENOG4105D5Q Arginine ornithine antiporter BIS30_06300 ENOG4107K5X Membrane-bound metal-dependent hydrolase BIS30_06305 ENOG4107QZ2 Sulfatase BIS30_06310 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BIS30_06315 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BIS30_06320 ENOG4105E0C molybdate abc transporter BIS30_06335 ENOG4105EEQ Na H antiporter BIS30_06340 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BIS30_06345 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BIS30_06350 ENOG4105EEM helicase BIS30_06355 ENOG4105EN6 Membrane BIS30_06365 ENOG4107ZQN disulfide bond BIS30_06370 ENOG4105C59 p-type ATPase BIS30_06375 ENOG4105C59 p-type ATPase BIS30_06380 ENOG410681U heavy metal transport detoxification protein BIS30_06385 ENOG4105VPX protein, conserved in bacteria BIS30_06390 ENOG4105D9R oxidoreductase BIS30_06395 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BIS30_06400 ENOG4105ME7 Membrane BIS30_06405 ENOG4105DRR Transcriptional regulator, GntR family BIS30_06410 ENOG4108UZ3 Transporter BIS30_06415 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BIS30_06440 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BIS30_06445 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BIS30_06455 ENOG4105XZU Preprotein translocase, subunit SecG BIS30_06480 ENOG4105KVH Transcriptional regulator BIS30_06505 ENOG4105DA5 (ABC) transporter BIS30_06535 ENOG4105R40 Glycine betaine carnitine choline BIS30_06540 ENOG4108HQR Glycine betaine BIS30_06545 ENOG4105E90 ABC transporter BIS30_06550 ENOG4108IJ8 ABC transporter BIS30_06555 ENOG4107HG4 Transcriptional regulator BIS30_06560 ENOG4105DQ6 Transposase BIS30_06570 ENOG4105R40 Glycine betaine carnitine choline BIS30_06575 ENOG4108HQR Glycine betaine BIS30_06580 ENOG4105E90 ABC transporter BIS30_06585 ENOG4108IJ8 ABC transporter BIS30_06590 ENOG4107HG4 Transcriptional regulator BIS30_06595 ENOG4108QCI YvbH-like oligomerisation region BIS30_06605 ENOG4105T65 Membrane-associated protein BIS30_06610 ENOG4108W0I acetyltransferase BIS30_06615 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BIS30_06620 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BIS30_06625 ENOG4105CP7 Triose-phosphate isomerase BIS30_06630 ENOG4105BZA Phosphoglycerate kinase BIS30_06640 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BIS30_06655 ENOG4105CMD Transcriptional regulator, GntR family BIS30_06660 ENOG4105DEN Luciferase family BIS30_06665 ENOG4107RT3 EamA-like transporter family BIS30_06675 ENOG4105VRS hydrolase family 18 BIS30_06680 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BIS30_06685 ENOG4107QR9 Iron-sulfur cluster binding protein BIS30_06710 ENOG4105BZU Histidine kinase BIS30_06715 ENOG4105KCT ABC transporter BIS30_06720 ENOG4108M15 ABC transporter BIS30_06725 ENOG4107R6F Alpha Beta Hydrolase Fold protein BIS30_06730 ENOG4108MJI response regulator BIS30_06745 ENOG4105EG2 ABC transporter, permease BIS30_06755 ENOG4107FKK extracellular solute-binding protein family 1 BIS30_06765 ENOG4105JXH GntR family transcriptional regulator BIS30_06770 ENOG4105DAA L-lactate BIS30_06775 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIS30_06785 ENOG4108ZPC Polysaccharide pyruvyl transferase BIS30_06790 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BIS30_06795 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BIS30_06800 ENOG4105D3Q Sugar transferase BIS30_06810 ENOG4105K64 Glycosyl transferase, family 2 BIS30_06820 ENOG4107QRS glycosyltransferase group 2 family protein BIS30_06825 ENOG41068W6 Capsular polysaccharide biosynthesis protein BIS30_06830 ENOG4108KMV Glycosyl transferase (Group 1 BIS30_06835 ENOG4105K64 Glycosyl transferase, family 2 BIS30_06840 ENOG4108PQP glycosyl transferase group 1 BIS30_06850 ENOG4108QV3 biosynthesis protein BIS30_06855 ENOG4105HTX biosynthesis protein BIS30_06865 ENOG4105EBR Carboxylesterase BIS30_06875 ENOG4105PY6 Phenolic acid decarboxylase BIS30_06880 ENOG4105NI3 Protein of unknown function (DUF3237) BIS30_06890 ENOG4105FQP Beta-lactamase BIS30_06895 ENOG4105EDQ levansucrase EC 2.4.1.10 BIS30_06900 ENOG4108HKT sucrose-6-phosphate hydrolase BIS30_06905 ENOG4107QTZ amino acid BIS30_06935 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BIS30_06940 ENOG4108URH decarboxylase BIS30_06945 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BIS30_06950 ENOG4105CHH sulfate transporter BIS30_06955 ENOG4108V2W Carbonate dehydratase BIS30_06960 ENOG4105C5I Dehydrogenase BIS30_06970 ENOG4105C19 ABC transporter BIS30_06975 ENOG4105EWM Histidine kinase BIS30_06985 ENOG4107A6P BIS30_06990 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BIS30_06995 ENOG4105KRI phosphocarrier protein (HPr BIS30_07000 ENOG4105CIE May be required for sporulation (By similarity) BIS30_07005 ENOG4105CHW UPF0052 protein BIS30_07010 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BIS30_07015 ENOG4108Z4K mutator MutT protein BIS30_07020 ENOG4105C3M thioredoxin reductase BIS30_07035 ENOG4105BZ1 (ABC) transporter BIS30_07045 ENOG4106FGC BIS30_07055 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BIS30_07060 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BIS30_07065 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BIS30_07070 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BIS30_07075 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BIS30_07080 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BIS30_07085 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BIS30_07090 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BIS30_07100 ENOG4108E16 pectate lyase BIS30_07105 ENOG4108S4C acetyltransferase BIS30_07110 ENOG4107XGZ Hydrolase BIS30_07115 ENOG4105HKU nucleoside recognition domain-containing protein BIS30_07120 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BIS30_07125 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BIS30_07130 ENOG4105CE4 GlcNAc 6-P deacetylase BIS30_07135 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BIS30_07140 ENOG4105FDP GntR family transcriptional regulator BIS30_07145 ENOG41088CQ domain protein BIS30_07155 ENOG4106A3M Cytochrome p-450 BIS30_07160 ENOG410625E BIS30_07175 ENOG41086DT Membrane protein of unknown function BIS30_07180 ENOG41067S9 phage shock protein C, PspC BIS30_07185 ENOG4108PY7 BIS30_07200 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BIS30_07205 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BIS30_07220 ENOG4105MKU Transcriptional regulator BIS30_07240 ENOG4105CN1 protease BIS30_07245 ENOG4105CRP Part of the ABC transporter FtsEX involved in BIS30_07250 ENOG4105CAK Cell division ATP-binding protein ftsE BIS30_07265 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BIS30_07275 ENOG4105MS2 ribosomal subunit Interface protein BIS30_07290 ENOG4105MQ3 flagellar protein FliS BIS30_07300 ENOG41083S7 flagellar protein FlaG BIS30_07305 ENOG4105I03 Flagellin BIS30_07310 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BIS30_07315 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BIS30_07320 ENOG4105MKD BIS30_07325 ENOG4105DTJ flagellar hook-associated protein BIS30_07330 ENOG4105E1Q flagellar hook-associated protein BIS30_07345 ENOG4105RU3 BIS30_07350 ENOG41081UC Inherit from COG: Competence protein BIS30_07370 ENOG4105WH1 Two component transcriptional regulator luxr family BIS30_07375 ENOG4105BZU Histidine kinase BIS30_07380 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BIS30_07385 ENOG4108KGH TRANSCRIPTIONal BIS30_07390 ENOG4105ESV Glycosyl transferase, family 4 BIS30_07395 ENOG4107EF8 Glycosyl transferase (Group 1 BIS30_07410 ENOG4105QZI O-Antigen Polymerase BIS30_07415 ENOG4105C6Y Udp-glucose 6-dehydrogenase BIS30_07420 ENOG4107RA4 Glycosyl transferase (Group 1 BIS30_07425 ENOG4105PSV Polysaccharide Biosynthesis Protein BIS30_07430 ENOG4105D3Q Sugar transferase BIS30_07440 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BIS30_07445 ENOG4105JFG SpoIID LytB domain protein BIS30_07460 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BIS30_07480 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BIS30_07485 ENOG4105EY8 ABC transporter BIS30_07505 ENOG4107VDP teichoic acid biosynthesis BIS30_07560 ENOG4105DG6 mannose-6-phosphate isomerase BIS30_07580 ENOG4108NHD germination protein BIS30_07585 ENOG4105C54 Major Facilitator superfamily BIS30_07590 ENOG4108KGH TRANSCRIPTIONal BIS30_07595 ENOG4105J7I hydrolase BIS30_07600 ENOG4105K4H Nlp p60 protein BIS30_07610 ENOG4105PNM synthesis protein BIS30_07620 ENOG4105N98 Capsule biosynthesis protein capB BIS30_07625 ENOG4105ETE Transcriptional regulator (LacI family BIS30_07630 ENOG4108RVA ribokinase BIS30_07635 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BIS30_07640 ENOG4105C2J ABC transporter BIS30_07645 ENOG4105CNN ABC, transporter BIS30_07650 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BIS30_07665 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BIS30_07670 ENOG4107FQX Alpha-acetolactate decarboxylase BIS30_07680 ENOG4107RSM transcriptional regulator BIS30_07695 ENOG4107XC4 flavin reductase domain protein, FMN-binding BIS30_07705 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BIS30_07715 ENOG4105CAH Chromate BIS30_07720 ENOG4105FGV Chromate BIS30_07730 ENOG4108WS4 fmn reductase BIS30_07735 ENOG4107V2S Transcriptional regulator BIS30_07745 ENOG410874W AraC family transcriptional regulator BIS30_07750 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BIS30_07790 ENOG4105C6Y Udp-glucose 6-dehydrogenase BIS30_07795 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BIS30_07800 ENOG4107YJ4 chain length determinant protein BIS30_07805 ENOG4105HTX biosynthesis protein BIS30_07815 ENOG4105KBK Zinc finger, swim domain protein BIS30_07820 ENOG4105C0D helicase BIS30_07825 ENOG410667J hydrolase BIS30_07830 ENOG4105E98 transcriptional regulator DeoR family BIS30_07835 ENOG4105Z8H single-stranded DNA-binding protein BIS30_07860 ENOG4108VAC response regulator BIS30_07870 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BIS30_07875 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BIS30_07885 ENOG4105CGA flagellar basal-body rod protein FlgG BIS30_07895 ENOG4105DFF Rod shape-determining protein mreb BIS30_07900 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BIS30_07905 ENOG4107MII Sugar-specific transcriptional regulator TrmB BIS30_07910 ENOG4105CZM Major Facilitator BIS30_07915 ENOG4108M26 parallel beta-helix repeat protein BIS30_07920 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BIS30_07925 ENOG41080V3 Major Facilitator superfamily BIS30_07930 ENOG4105D3W isochorismatase BIS30_07935 ENOG4107P26 BIS30_07940 ENOG4105BZU Histidine kinase BIS30_07950 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BIS30_07960 ENOG4105FRN stage II sporulation protein BIS30_07965 ENOG4107TCE N-acetyltransferase BIS30_07975 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) BIS30_07985 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BIS30_07990 ENOG4107TXC Transcriptional regulator BIS30_07995 ENOG4106BRK BIS30_08000 ENOG4108RYK Nad-dependent epimerase dehydratase BIS30_08005 ENOG4108Z40 Transcriptional regulator BIS30_08010 ENOG4105CQM Urea amidohydrolase subunit alpha BIS30_08015 ENOG4105KI2 Urea amidohydrolase subunit beta BIS30_08020 ENOG4108YZ9 Urea amidohydrolase subunit gamma BIS30_08025 ENOG4108IV0 ABC, transporter BIS30_08030 ENOG4105C0Z ABC transporter BIS30_08040 ENOG4105C32 Amino acid ABC transporter (Permease) BIS30_08045 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein BIS30_08070 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BIS30_08080 ENOG4108TF4 von Willebrand factor, type A BIS30_08090 ENOG4105JFG SpoIID LytB domain protein BIS30_08095 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BIS30_08105 ENOG4106778 Protein of unknown function (DUF1146) BIS30_08115 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BIS30_08120 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BIS30_08125 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BIS30_08130 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BIS30_08155 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) BIS30_08165 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BIS30_08170 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BIS30_08175 ENOG4108UIC UPF0340 protein BIS30_08180 ENOG4108YZG isomerase BIS30_08185 ENOG4107WAU Protein tyrosine phosphatase BIS30_08190 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BIS30_08195 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BIS30_08205 ENOG4108ZXQ stage ii sporulation protein r BIS30_08220 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BIS30_08225 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BIS30_08240 ENOG4107TT2 Auxin Efflux Carrier BIS30_08245 ENOG4105C6K Malic enzyme BIS30_08250 ENOG4107104 thymidine kinase BIS30_08255 ENOG41082DI 50s ribosomal protein l31 BIS30_08260 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BIS30_08270 ENOG4105CBT Fructose-1,6-bisphosphatase BIS30_08275 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BIS30_08280 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway BIS30_08285 ENOG4105D2N Aldolase BIS30_08290 ENOG410812K response regulator receiver protein BIS30_08300 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BIS30_08310 ENOG4105C1G acyl-Coa dehydrogenase BIS30_08315 ENOG4105DF6 Fe-S oxidoreductase BIS30_08325 ENOG4105E5J UV damage endonuclease BIS30_08335 ENOG4105NAE bifunctional deaminase-reductase domain protein BIS30_08340 ENOG4105BZ1 (ABC) transporter BIS30_08345 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BIS30_08360 ENOG4105R3A Nitrate reductase BIS30_08365 ENOG4108IUE nitrate reductase beta subunit BIS30_08385 ENOG4107V6Q Cyclic nucleotide-binding domain BIS30_08395 ENOG4105C75 arginyL-tRNA synthetase BIS30_08400 ENOG410684U Domain of unknown function (DUF1934) BIS30_08410 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E BIS30_08455 ENOG4107JM4 Tetratricopeptide repeat BIS30_08465 ENOG4105CYW agmatinase BIS30_08470 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BIS30_08475 ENOG4105BZ4 penicillin-binding protein BIS30_08480 ENOG4108XFG YwhD family BIS30_08485 ENOG4108Z4T Peptidase M50 BIS30_08490 ENOG41069HH 4-oxalocrotonate tautomerase BIS30_08495 ENOG41067TZ transcriptional regulator, MarR family BIS30_08500 ENOG4105C22 threonyL-tRNA synthetase BIS30_08515 ENOG4105DCI Phosphohydrolase BIS30_08525 ENOG4108VCI transcription factor, rsfa family BIS30_08530 ENOG4108RNG Permease of the drug metabolite transporter BIS30_08535 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BIS30_08540 ENOG4105DUM transcriptional regulator, lysR family BIS30_08545 ENOG4108IJ2 phosphate acetyltransferase BIS30_08560 ENOG4105CHM Aminotransferase BIS30_08570 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase BIS30_08575 ENOG4105CHR reductase BIS30_08580 ENOG4106CHD Bacilysin biosynthesis protein bacB BIS30_08585 ENOG41061WN bacilysin biosynthesis protein BIS30_08590 ENOG4105FCW Major Facilitator superfamily BIS30_08605 ENOG4105C26 Dehydrogenase BIS30_08610 ENOG4105D82 Glutamate dehydrogenase BIS30_08620 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BIS30_08625 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BIS30_08630 ENOG4105C1B dTDP-glucose 4-6-dehydratase BIS30_08635 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BIS30_08640 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BIS30_08645 ENOG4107TY6 Acylneuraminate cytidylyltransferase BIS30_08655 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BIS30_08660 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BIS30_08700 ENOG4105C26 Dehydrogenase BIS30_08705 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BIS30_08710 ENOG4108RJ9 Glycosyl transferase, family 2 BIS30_08730 ENOG4105DWF phosphomethylpyrimidine kinase BIS30_08745 ENOG4105C5Y PTS System BIS30_08750 ENOG4108QTI )-transporter BIS30_08770 ENOG4105DEN Luciferase family BIS30_08775 ENOG4108DBC nitroreductase BIS30_08825 ENOG4107BMA Transglycosylase associated protein BIS30_08835 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BIS30_08840 ENOG4105WH5 Teichoic acid glycosylation protein BIS30_08865 ENOG4107ZXU DSBA oxidoreductase BIS30_08870 ENOG4105DBE peroxidase BIS30_08875 ENOG410650H (LipO)protein BIS30_08880 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BIS30_08890 ENOG4105CMU LysR family (Transcriptional regulator BIS30_08895 ENOG4105VAW lrga family BIS30_08900 ENOG41067MG lrgb family BIS30_08905 ENOG4108RDQ ABC transporter BIS30_08930 ENOG41067MG lrgb family BIS30_08935 ENOG4105D8G Major Facilitator superfamily BIS30_08945 ENOG4105DR4 Methyltransferase BIS30_08955 ENOG4108YV3 Protein of unknown function (DUF2711) BIS30_08960 ENOG4105CK1 PTS System BIS30_08980 ENOG4105X1N Glycosyl transferase family 8 BIS30_08990 ENOG4105GVJ transcriptional regulator BIS30_08995 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BIS30_09000 ENOG4105IIU Aminopeptidase BIS30_09015 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BIS30_09030 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BIS30_09035 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BIS30_09045 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BIS30_09050 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BIS30_09055 ENOG4105CM2 brancheD-chain amino acid aminotransferase BIS30_09060 ENOG4105F8D glycoside hydrolase family 4 BIS30_09065 ENOG4105VCP PTS System BIS30_09070 ENOG4105CK1 PTS System BIS30_09075 ENOG4105VZJ PTS System BIS30_09080 ENOG4105EMD TRANSCRIPTIONal BIS30_09085 ENOG4108VX5 3-methyladenine DNA glycosylase BIS30_09090 ENOG4105CH6 catalase BIS30_09105 ENOG4105DA5 (ABC) transporter BIS30_09110 ENOG41069JR BIS30_09130 ENOG4105ETS cytosine purines uracil thiamine allantoin BIS30_09135 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BIS30_09140 ENOG4108JJ8 (ABC) transporter BIS30_09145 ENOG4108JJ9 ABC, transporter BIS30_09150 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BIS30_09155 ENOG4105C4M (Ubiquinol oxidase) subunit I BIS30_09160 ENOG4105D2K citrate carrier protein BIS30_09175 ENOG4107BJW polysaccharide deacetylase BIS30_09205 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BIS30_09215 ENOG4105CMR udp-glucose 4-epimerase BIS30_09225 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BIS30_09255 ENOG4105DTD Dehydrogenase BIS30_09260 ENOG4108IIH CoA-transferase subunit B BIS30_09265 ENOG4105D6N CoA-transferase, subunit a BIS30_09270 ENOG4105CY2 Citrate transporter BIS30_09280 ENOG4105DHI Methyltransferase BIS30_09300 ENOG4105CH6 catalase BIS30_09305 ENOG4105D4T Citrate transporter BIS30_09310 ENOG410900G Protein of unknown function (DUF421) BIS30_09320 ENOG4105CS2 ec 3.2.1.21 BIS30_09325 ENOG4105C5Y PTS System BIS30_09330 ENOG4105CID antiterminator BIS30_09340 ENOG4105DEU major facilitator superfamily BIS30_09345 ENOG4105C1J atp-dependent rna helicase BIS30_09350 ENOG4107TDE lipolytic protein G-D-S-L family BIS30_09470 ENOG4107TS3 membrane protein, TerC BIS30_09475 ENOG4107YZX Universal stress protein BIS30_09480 ENOG4105CS2 ec 3.2.1.21 BIS30_09485 ENOG4105C5Y PTS System BIS30_09520 ENOG4107EV6 Inherit from COG: YD repeat protein BIS30_09535 ENOG4106Z5D Glycoside Hydrolase Family 43 BIS30_09540 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BIS30_09550 ENOG4105C84 Histidine ammonia-lyase BIS30_09555 ENOG4105CGP Urocanate hydratase BIS30_09560 ENOG4105CI2 imidazolone-5-propionate hydrolase BIS30_09565 ENOG4107W25 arginase agmatinase formiminoglutamase BIS30_09575 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BIS30_09580 ENOG4105D9N nucleoside BIS30_09590 ENOG4107RHR regulatoR BIS30_09595 ENOG4108TM9 integral membrane protein BIS30_09600 ENOG4105ENY Ethanolamine utilization protein eutH BIS30_09605 ENOG4108PGP mmge prpd family protein BIS30_09610 ENOG4105CH2 amidohydrolase BIS30_09620 ENOG4108HW4 amino acid AbC transporter BIS30_09625 ENOG4105EAB amino acid AbC transporter BIS30_09630 ENOG4108XSB acetyltransferase, (GNAT) family BIS30_09635 ENOG4105CPU Monooxygenase BIS30_09645 ENOG4107QHE Choloylglycine hydrolase BIS30_09650 ENOG410667J hydrolase BIS30_09680 ENOG4108V5C ABC transporter BIS30_09710 ENOG4105D2N Aldolase BIS30_09715 ENOG4107TRN Xylose isomerase domain protein TIM barrel BIS30_09720 ENOG4105F0H myo-inositol catabolism protein BIS30_09725 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BIS30_09735 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BIS30_09740 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) BIS30_09745 ENOG4105D7K pfkb domain protein BIS30_09755 ENOG4105C26 Dehydrogenase BIS30_09765 ENOG4105CPC Aldo Keto reductase BIS30_09780 ENOG4107QNK )-transporter BIS30_09795 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BIS30_09800 ENOG4105ST3 Transcriptional regulator BIS30_09805 ENOG4105C26 Dehydrogenase BIS30_09815 ENOG41085PJ rdd domain containing protein BIS30_09830 ENOG4105J7D transcriptional regulator BIS30_09835 ENOG4107JEE Short-chain dehydrogenase reductase Sdr BIS30_09840 ENOG41061AU MarR family Transcriptional regulator BIS30_09850 ENOG41067MG lrgb family BIS30_09865 ENOG4105BZW Glycerate kinase BIS30_09870 ENOG4105G3Z GntR family transcriptional regulator BIS30_09875 ENOG4105CMG Carbohydrate kinase BIS30_09880 ENOG4105C6Z Gluconate BIS30_09885 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BIS30_09890 ENOG4105D3R alkyl hydroperoxide reductase BIS30_09895 ENOG4108JU3 Alkyl hydroperoxide reductase BIS30_09905 ENOG4105CS2 ec 3.2.1.21 BIS30_09915 ENOG4108S3Y transcriptional regulator BIS30_09925 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BIS30_09930 ENOG4105DVF Cytosine-specific methyltransferase BIS30_09955 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BIS30_09980 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BIS30_09985 ENOG4105WQG acetyltransferase BIS30_09990 ENOG410780I phosphoprotein phosphatase activity BIS30_10000 ENOG41066UZ arginase EC 3.5.3.1 BIS30_10005 ENOG4108IQI permease BIS30_10010 ENOG4105C8Y Acetylornithine aminotransferase BIS30_10015 ENOG4108JUB Transcriptional regulator BIS30_10025 ENOG4105C0H protease BIS30_10030 ENOG4105Q2H domain protein BIS30_10045 ENOG4105BZU Histidine kinase BIS30_10050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BIS30_10075 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BIS30_10080 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BIS30_10085 ENOG4105CDU Replicative dna helicase BIS30_10110 ENOG4105DJ2 Major Facilitator Superfamily BIS30_10115 ENOG4105EDW glycosyl transferase, family 39 BIS30_10120 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BIS30_10125 ENOG4105BZR domain protein BIS30_10130 ENOG4108XMW Membrane BIS30_10145 ENOG4105KVH Transcriptional regulator BIS30_10150 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BIS30_10180 ENOG4105D94 Major Facilitator Superfamily BIS30_10185 ENOG4107RSM transcriptional regulator BIS30_10190 ENOG41082BV acetyltransferase BIS30_10195 ENOG41081I9 integral membrane protein BIS30_10205 ENOG4105KVH Transcriptional regulator BIS30_10210 ENOG41079CX BIS30_10215 ENOG4108U05 Transcriptional regulator BIS30_10220 ENOG41082BV acetyltransferase BIS30_10230 ENOG4105C7Z Conserved Protein BIS30_10235 ENOG4107FCW Abortive infection protein BIS30_10245 ENOG4108UW5 maltose o-acetyltransferase BIS30_10250 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BIS30_10260 ENOG4105CGK Exodeoxyribonuclease III BIS30_10265 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BIS30_10270 ENOG4108UUM single-stranded DNA-binding protein BIS30_10275 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BIS30_10280 ENOG4105C3G gtp-binding protein BIS30_10285 ENOG4108J2R molybdopterin oxidoreductase BIS30_10290 ENOG4105VDK protein, conserved in bacteria BIS30_10300 ENOG4108ZDA Sporulation protein YyaC BIS30_10305 ENOG4105FA0 parb-like partition protein BIS30_10310 ENOG4107QJE Chromosome Partitioning Protein BIS30_10325 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BIS30_10330 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BIS30_10335 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BIS30_10350 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BIS30_10360 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BIS30_10365 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BIS30_10370 ENOG410848D S4 domain protein YaaA BIS30_10385 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BIS30_10390 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BIS30_10425 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BIS30_10435 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BIS30_10440 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BIS30_10445 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BIS30_10455 ENOG4105ZMH deoxynucleoside kinase BIS30_10465 ENOG4105VRS hydrolase family 18 BIS30_10470 ENOG4105GTG Isochorismatase BIS30_10475 ENOG4108Z6B deaminase BIS30_10480 ENOG4105C6E dna polymerase iii BIS30_10485 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BIS30_10490 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BIS30_10500 ENOG41067KS pro-sigma K processing BIS30_10540 ENOG4105CDW Resistance protein BIS30_10545 ENOG4105CXN decarboxylase BIS30_10550 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BIS30_10555 ENOG4105X0R protein from nitrogen regulatory protein P-II BIS30_10560 ENOG4105XVJ Protein of unknown function (DUF327) BIS30_10565 ENOG4105FA2 dna polymerase iii BIS30_10570 ENOG4105MA4 psp1 domain protein BIS30_10575 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) BIS30_10580 ENOG41060K3 Methyltransferase BIS30_10585 ENOG4105VC4 domain protein BIS30_10590 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BIS30_10595 ENOG4105KRN Transcriptional regulator, abrb family BIS30_10600 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BIS30_10605 ENOG4105F8V Hydrolase, tatD family BIS30_10610 ENOG41069ER domain protein BIS30_10620 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BIS30_10625 ENOG4105XFA sporulation peptidase YabG BIS30_10630 ENOG4105W42 Veg protein BIS30_10635 ENOG4105XEW small acid-soluble spore protein BIS30_10640 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BIS30_10645 ENOG4105DFT pur operon repressor BIS30_10650 ENOG4105KME endoribonuclease L-psp BIS30_10655 ENOG4105K4W Could be involved in septation (By similarity) BIS30_10665 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BIS30_10670 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BIS30_10675 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BIS30_10680 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BIS30_10690 ENOG4108JA2 transcriptioN-repair coupling factor BIS30_10695 ENOG4108M14 stage v sporulation protein t BIS30_10705 ENOG4108IY2 MazG family BIS30_10710 ENOG41082I2 s4 domain protein BIS30_10715 ENOG4105VYY sporulation protein yabp BIS30_10730 ENOG41060GV RNA binding s1 domain protein BIS30_10765 ENOG4108UGV hypoxanthine phosphoribosyltransferase BIS30_10770 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BIS30_10780 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BIS30_10785 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BIS30_10790 ENOG4105C6T cysteine synthase BIS30_10795 ENOG4105CRQ synthase (Component I) BIS30_10800 ENOG4105DDQ anthranilate synthase BIS30_10805 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BIS30_10810 ENOG4105EEI dihydropteroate synthase BIS30_10815 ENOG4105KRF dihydroneopterin aldolase BIS30_10820 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BIS30_10830 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BIS30_10835 ENOG4105CRK lysyL-tRNA synthetase BIS30_10865 ENOG4108Z0C Uvrb UvrC protein BIS30_10870 ENOG41066A3 ATP guanido phosphotransferase BIS30_10880 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BIS30_10885 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BIS30_10890 ENOG4105CTP PilT protein domain protein BIS30_10895 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BIS30_10900 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BIS30_10905 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BIS30_10915 ENOG4105D7W serine acetyltransferase BIS30_10920 ENOG4105C8N cysteinyl-tRNA synthetase BIS30_10925 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BIS30_10930 ENOG4105C2N RNA methyltransferase TrmH family group 3 BIS30_10935 ENOG4105M0M Tetracycline resistance protein BIS30_10955 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BIS30_10960 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BIS30_10970 ENOG4108VZM 50s ribosomal protein L10 BIS30_10975 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BIS30_10980 ENOG4107Y49 methyltransferase BIS30_10985 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BIS30_10990 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BIS30_10995 ENOG4105XPM ribosomal protein BIS30_11000 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BIS30_11005 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BIS30_11010 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BIS30_11015 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BIS30_11020 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BIS30_11025 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BIS30_11030 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BIS30_11035 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BIS30_11040 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BIS30_11045 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BIS30_11050 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BIS30_11055 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BIS30_11060 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BIS30_11065 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BIS30_11070 ENOG41082SA 50s ribosomal protein l29 BIS30_11075 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BIS30_11080 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BIS30_11090 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BIS30_11100 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BIS30_11105 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BIS30_11110 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BIS30_11115 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BIS30_11120 ENOG4105VPB 50S ribosomal protein L30 BIS30_11125 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BIS30_11130 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BIS30_11140 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BIS30_11150 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BIS30_11160 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BIS30_11165 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BIS30_11170 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BIS30_11175 ENOG4108ZT0 50S ribosomal protein l17 BIS30_11180 ENOG4108JJB ABC transporter BIS30_11185 ENOG4108JJB ABC transporter BIS30_11190 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BIS30_11195 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BIS30_11200 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BIS30_11205 ENOG4108UJD 30S ribosomal protein S9 BIS30_11215 ENOG4108I0C methyltransferase BIS30_11230 ENOG4105D1F ATP-binding protein BIS30_11245 ENOG4108NMV polysaccharide deacetylase BIS30_11315 ENOG4105CHH sulfate transporter BIS30_11325 ENOG4108SA1 esterase BIS30_11345 ENOG410874W AraC family transcriptional regulator BIS30_11350 ENOG4105EHZ conserved protein UCP016719 BIS30_11355 ENOG4105D17 glycoside hydrolase, family 3 domain protein BIS30_11375 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BIS30_11385 ENOG4105EWC Purine nucleoside phosphorylase BIS30_11415 ENOG4105EMN RNA polymerase sigma factor BIS30_11425 ENOG4105C8B TIGR00159 family BIS30_11430 ENOG4107U5W ybbr family BIS30_11435 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BIS30_11445 ENOG4108TWJ NADH dehydrogenase subunit 5 BIS30_11465 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BIS30_11500 ENOG4105E5W Transporter BIS30_11560 ENOG4105G0J serine threonine protein kinase BIS30_11570 ENOG4106K80 BIS30_11580 ENOG4106DDH Sporulation-specific SASP protein BIS30_11590 ENOG4108HWY Beta-lactamase BIS30_11595 ENOG4107E6A Cytochrome p-450 BIS30_11610 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BIS30_11615 ENOG4105CXY transporter BIS30_11625 ENOG410645S MarR family Transcriptional regulator BIS30_11630 ENOG4105DCM major facilitator superfamily BIS30_11645 ENOG410631K Membrane BIS30_11650 ENOG4106AXJ AraC family transcriptional regulator BIS30_11655 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BIS30_11660 ENOG4108TCS Glutamyl endopeptidase BIS30_11670 ENOG4108WC5 Alpha Beta Hydrolase Fold protein BIS30_11675 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BIS30_11680 ENOG4107ZTW SNARE associated Golgi BIS30_11700 ENOG4105C72 UPF0176 protein BIS30_11715 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BIS30_11720 ENOG4108X79 transcriptional regulator BIS30_11730 ENOG4105CM2 brancheD-chain amino acid aminotransferase BIS30_11735 ENOG4108IQI permease BIS30_11740 ENOG4108J5H Homocysteine s-methyltransferase BIS30_11755 ENOG4105CSV Glutaminase BIS30_11775 ENOG4105C26 Dehydrogenase BIS30_11780 ENOG4105DJB Major Facilitator Superfamily BIS30_11785 ENOG4105EQX glucarate dehydratase BIS30_11790 ENOG41073TP transcriptional regulator BIS30_11795 ENOG4105CTX dehydratase BIS30_11810 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BIS30_11845 ENOG4105MUA Resistance protein BIS30_11855 ENOG4105DGI Alkaline phosphatase BIS30_11860 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BIS30_11865 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BIS30_11870 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BIS30_11875 ENOG4107EPV Aminotransferase class V BIS30_11880 ENOG4105C0R drug resistance transporter emrb qaca subfamily BIS30_11885 ENOG4105J7D transcriptional regulator BIS30_11890 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BIS30_11900 ENOG41060AI SEC-C motif BIS30_11910 ENOG4108SDH ABC, transporter BIS30_11915 ENOG4107SET aldo keto reductase BIS30_11940 ENOG4105DQ6 Transposase BIS30_11960 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BIS30_11970 ENOG4105DSE periplasmic solute binding protein BIS30_11975 ENOG4105DIK (ABC) transporter BIS30_11985 ENOG4105DEN Luciferase family BIS30_11990 ENOG4108N0M stress protein BIS30_11995 ENOG4106FN3 tellurium resistance protein BIS30_12000 ENOG4106FN3 tellurium resistance protein BIS30_12005 ENOG4107TS3 membrane protein, TerC BIS30_12020 ENOG41079KZ Major Facilitator Superfamily BIS30_12025 ENOG4108A65 Transcriptional regulator BIS30_12030 ENOG4108IJ7 Glycine betaine BIS30_12035 ENOG4107SQ8 Glycine betaine BIS30_12070 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BIS30_12105 ENOG4105EIG urea carboxylase-associated protein 1 BIS30_12110 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BIS30_12115 ENOG4105I1F Resistance protein BIS30_12120 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BIS30_12125 ENOG41089UC methyltransferase, type 11 BIS30_12130 ENOG4105C5Q Transcriptional regulator BIS30_12135 ENOG4105I82 acetyl xylan esterase BIS30_12140 ENOG410756H nucleotidyltransferase BIS30_12150 ENOG4105C26 Dehydrogenase BIS30_12155 ENOG4105CK7 Sodium proline symporter BIS30_12160 ENOG4107YHD transcriptional regulator BIS30_12170 ENOG4108PJD permease BIS30_12175 ENOG4105U6C Alpha beta hydrolase fold protein BIS30_12185 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BIS30_12190 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BIS30_12195 ENOG4108IFG nitrite reductase, (NAD(P)H) BIS30_12200 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BIS30_12220 ENOG4105S7A ErfK ybiS ycfS ynhG family protein BIS30_12230 ENOG4105CKI cobalamin synthesis protein BIS30_12235 ENOG4105E5Q amino acid AbC transporter BIS30_12240 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein BIS30_12250 ENOG4105HHM rdd domain containing protein BIS30_12260 ENOG4105K56 Transcriptional regulator BIS30_12270 ENOG4108VEN abc transporter atp-binding protein BIS30_12275 ENOG4105CS2 ec 3.2.1.21 BIS30_12295 ENOG41080HJ 6-phospho 3-hexuloisomerase BIS30_12300 ENOG4108VA3 3-hexulose-6-phosphate synthase BIS30_12305 ENOG4105KVH Transcriptional regulator BIS30_12315 ENOG4105CEY Amp-dependent synthetase and ligase BIS30_12345 ENOG4105SX7 Transporter BIS30_12355 ENOG4105W8Z 4'-phosphopantetheinyl transferase BIS30_12365 ENOG4105CDA abc transporter atp-binding protein BIS30_12370 ENOG4105DRP amino acid AbC transporter BIS30_12380 ENOG4106P55 Transcriptional regulator BIS30_12385 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BIS30_12390 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BIS30_12395 ENOG41069ZX BIS30_12400 ENOG41069ZX BIS30_12410 ENOG4105DUX Transporter BIS30_12425 ENOG4105E1K spore germination protein BIS30_12445 ENOG4107WD8 ABC transporter, permease BIS30_12450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BIS30_12455 ENOG4105BZU Histidine kinase BIS30_12475 ENOG4105CFH Aspartokinase BIS30_12480 ENOG4105DHS permease protein BIS30_12485 ENOG4105CM4 permease protein BIS30_12490 ENOG4108IPW abc transporter atp-binding protein BIS30_12505 ENOG4105R8C Transcriptional regulator BIS30_12510 ENOG4108DBC nitroreductase BIS30_12515 ENOG41067V3 Antibiotic biosynthesis monooxygenase BIS30_12520 ENOG4105YVS arsR family transcriptional regulator BIS30_12530 ENOG4108JPW Aminotransferase BIS30_12535 ENOG4105C26 Dehydrogenase BIS30_12545 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BIS30_12550 ENOG4105KTB nuclear export factor GLE1 BIS30_12555 ENOG4108T5E Copper resistance protein BIS30_12560 ENOG4108ZYE Transcriptional regulator BIS30_12585 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BIS30_12590 ENOG4108ZX0 Signal peptidase I BIS30_12615 ENOG4105E7W lamb ycsf family protein BIS30_12620 ENOG4105C5A transporter BIS30_12625 ENOG4105CFM UPF0317 protein BIS30_12630 ENOG4105P4J Allophanate hydrolase, subunit 1 BIS30_12640 ENOG4107258 Transcriptional regulator BIS30_12645 ENOG4105XJB lipolytic protein G-D-S-L family BIS30_12655 ENOG41061CK Antibiotic biosynthesis monooxygenase BIS30_12660 ENOG4107RVG penicillin-binding protein BIS30_12665 ENOG4107QM2 Aldo Keto reductase BIS30_12670 ENOG4105ETD TRANSCRIPTIONal BIS30_12680 ENOG4105HMZ Methyltransferase BIS30_12685 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BIS30_12700 ENOG410606W general stress protein BIS30_12710 ENOG4105VCH membrane BIS30_12720 ENOG4105C9U ATP-dependent DNA helicase RecQ BIS30_12735 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BIS30_12740 ENOG4107R8N Glycosyl transferase, family 2 BIS30_12750 ENOG4105C0X amino acid BIS30_12770 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BIS30_12775 ENOG4107BMA Transglycosylase associated protein BIS30_12780 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BIS30_12785 ENOG4105EU9 BIS30_12790 ENOG4105QVS general stress protein BIS30_12810 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BIS30_12815 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BIS30_12820 ENOG4108MRH transcriptional regulatory protein BIS30_12825 ENOG4107QJT sodium dicarboxylate symporter BIS30_12830 ENOG4106F5Q Membrane BIS30_12840 ENOG4105CJ1 ABC, transporter BIS30_12855 ENOG4105FDT acyl-CoA dehydrogenase BIS30_12875 ENOG4105SZ6 Thioredoxin BIS30_12880 ENOG4105CPF Cell wall formation (By similarity) BIS30_12885 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BIS30_12890 ENOG4105C1J atp-dependent rna helicase BIS30_12895 ENOG410905X membrane-flanked domain protein BIS30_12900 ENOG4105CKV Membrane BIS30_12910 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BIS30_12915 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BIS30_12920 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BIS30_12930 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BIS30_12935 ENOG4107MMM Anti-sigma-factor antagonist BIS30_12940 ENOG4105FUA antagonist BIS30_12945 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BIS30_12950 ENOG4107SGM protein serine threonine phosphatase BIS30_12955 ENOG4105WN5 stage II sporulation protein BIS30_12960 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BIS30_12970 ENOG41064BQ Phosphatase BIS30_13030 ENOG4105VUF Transcriptional regulator BIS30_13035 ENOG4105E1F short-chain dehydrogenase reductase BIS30_13040 ENOG4107SET aldo keto reductase BIS30_13045 ENOG4105EMU Dehydrogenase BIS30_13050 ENOG4105DTD Dehydrogenase BIS30_13060 ENOG4105EMU Dehydrogenase BIS30_13065 ENOG4105ECK Fatty Acid Desaturase BIS30_13070 ENOG4105VEQ Cold shock protein BIS30_13075 ENOG4108VJ1 Transcriptional regulator (CarD family BIS30_13085 ENOG4108IMY Transcriptional regulator BIS30_13090 ENOG41086D8 Transcriptional regulator BIS30_13100 ENOG4105CZ9 Domain of unknown function (DU1801) BIS30_13105 ENOG4105GIG BIS30_13115 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BIS30_13125 ENOG4105T38 integral membrane protein BIS30_13130 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BIS30_13135 ENOG4108ZMQ domain protein BIS30_13140 ENOG4105MJ9 esterase BIS30_13145 ENOG4107Z6X Transcriptional regulator BIS30_13160 ENOG41082YX Transcriptional regulator, arsr family BIS30_13165 ENOG4107R5R arsenical pump membrane protein BIS30_13170 ENOG4108UXE Protein tyrosine phosphatase BIS30_13175 ENOG4105Z7P Acetyltransferase (GNAT) family BIS30_13180 ENOG4107Y9U Membrane BIS30_13190 ENOG4108SQ9 flavin reductase domain protein, FMN-binding BIS30_13195 ENOG4108ZHR arsR family transcriptional regulator BIS30_13200 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BIS30_13215 ENOG4105ENE Histidine kinase BIS30_13220 ENOG4108VB1 regulatoR BIS30_13225 ENOG4105EYF MMPL domain protein BIS30_13235 ENOG4108UMN azlc family BIS30_13250 ENOG4108UQV Membrane BIS30_13255 ENOG4108Z5V transcriptional regulator, merr family BIS30_13260 ENOG41076HS cation diffusion facilitator family transporter BIS30_13265 ENOG4108TVJ Nitroreductase BIS30_13270 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BIS30_13275 ENOG4108VGI doxx family BIS30_13280 ENOG4105XXY Thioredoxin BIS30_13285 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BIS30_13305 ENOG410900G Protein of unknown function (DUF421) BIS30_13325 ENOG4105PF9 Transcriptional regulator BIS30_13335 ENOG4105WQG acetyltransferase BIS30_13345 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BIS30_13350 ENOG4105ETE Transcriptional regulator (LacI family BIS30_13355 ENOG4107QNK )-transporter BIS30_13360 ENOG4105C54 Major Facilitator superfamily BIS30_13365 ENOG4105C54 Major Facilitator superfamily BIS30_13370 ENOG4107TRE AP endonuclease, family 2 BIS30_13375 ENOG4105F27 Major Facilitator BIS30_13390 ENOG4105C85 amino acid BIS30_13400 ENOG41062A4 Transcriptional regulator BIS30_13405 ENOG4105EYF MMPL domain protein BIS30_13410 ENOG4108TVJ Nitroreductase BIS30_13415 ENOG4105FS7 Transcriptional regulator BIS30_13420 ENOG4108JCI Transcriptional regulator BIS30_13435 ENOG4105C2C drug resistance transporter, Bcr CflA BIS30_13445 ENOG4105DRR Transcriptional regulator, GntR family BIS30_13450 ENOG4105VRS hydrolase family 18 BIS30_13470 ENOG4105G6Z alkaline phosphatase BIS30_13480 ENOG4108YM7 Gcn5-related n-acetyltransferase BIS30_13485 ENOG4107TVP HD domain protein BIS30_13490 ENOG41090UD (LipO)protein BIS30_13495 ENOG4105F27 Major Facilitator BIS30_13500 ENOG4105VZJ PTS System BIS30_13505 ENOG4105VCP PTS System BIS30_13510 ENOG4105CK1 PTS System BIS30_13515 ENOG4105CS2 ec 3.2.1.21 BIS30_13520 ENOG4108TZY GntR Family Transcriptional Regulator BIS30_13525 ENOG4105EVU fructokinase BIS30_13530 ENOG4105DG6 mannose-6-phosphate isomerase BIS30_13535 ENOG4105D3P Mannan endo-1,4-beta-mannosidase BIS30_13580 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BIS30_13585 ENOG4105K8N protein family UPF0079, ATPase BIS30_13590 ENOG41072GX Peptidase M22 Glycoprotease BIS30_13595 ENOG410801F ribosomal-protein-alanine acetyltransferase BIS30_13600 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BIS30_13605 ENOG4105C5H ABC transporter BIS30_13610 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BIS30_13615 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BIS30_13620 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BIS30_13625 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BIS30_13635 ENOG4108TYN CAAX amino terminal protease family protein BIS30_13640 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BIS30_13645 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BIS30_13655 ENOG4105PGZ NB-ARC domain BIS30_13660 ENOG4105CPQ Dehydrogenase BIS30_13665 ENOG4105CT4 transporter BIS30_13675 ENOG41087YS Phage shock protein A BIS30_13680 ENOG4105DQX Zinc finger domain BIS30_13685 ENOG4108WV1 Pfam:DUF477 BIS30_13695 ENOG4108ZMR Ion transport 2 domain-containing protein BIS30_13700 ENOG4107QNK )-transporter BIS30_13725 ENOG4105DQ6 Transposase BIS30_13740 ENOG4107YUH hydrolase BIS30_13750 ENOG4107STQ Multicopper oxidase BIS30_13755 ENOG4105C85 amino acid BIS30_13770 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BIS30_13790 ENOG4105C7N Xanthine uracil vitamin C permease BIS30_13815 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BIS30_13820 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BIS30_13825 ENOG4105C83 adenylosuccinate lyase BIS30_13830 ENOG4105C8V SAICAR synthetase BIS30_13835 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BIS30_13840 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BIS30_13845 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BIS30_13855 ENOG4105CXB phosphoribosylaminoimidazole synthetase BIS30_13860 ENOG4108V3E phosphoribosylglycinamide formyltransferase BIS30_13865 ENOG4105DC1 bifunctional purine biosynthesis protein purh BIS30_13870 ENOG4105C12 Phosphoribosylglycinamide synthetase BIS30_13880 ENOG4105DVH amino acid BIS30_13895 ENOG4108R5T secreted protein BIS30_13900 ENOG4105KGF protein, YerC YecD BIS30_13905 ENOG4105CBC glutamate synthase BIS30_13910 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BIS30_13915 ENOG4105C4R Atp-dependent dna helicase BIS30_13920 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BIS30_13935 ENOG4105CRN Aminoglycoside phosphotransferase BIS30_13940 ENOG4105KT7 mgtC SapB transporter BIS30_13945 ENOG4105CK7 Sodium proline symporter BIS30_13950 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BIS30_13955 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BIS30_13960 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BIS30_13965 ENOG4108IG5 Transcriptional regulator BIS30_13975 ENOG4105CBD Diacylglycerol kinase BIS30_13980 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BIS30_13985 ENOG4105CVR type I restriction-modification system BIS30_13990 ENOG41082EK Restriction modification system DNA (Specificity BIS30_13995 ENOG4105DZR Type I site-specific deoxyribonuclease BIS30_14035 ENOG4105CDY transcriptional regulatory protein BIS30_14045 ENOG4105M4P Tetr family transcriptional regulator BIS30_14050 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein BIS30_14055 ENOG4107S9F NmrA family BIS30_14060 ENOG4105KHM amidohydrolase 2 BIS30_14065 ENOG4105ST3 Transcriptional regulator BIS30_14080 ENOG4105WEF catalase BIS30_14085 ENOG4105M18 -acetyltransferase BIS30_14100 ENOG4105C2F Histidine kinase BIS30_14105 ENOG4105EQD regulatoR BIS30_14110 ENOG410769Z extracellular solute-binding protein family 1 BIS30_14115 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BIS30_14120 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component BIS30_14125 ENOG4105F5H Glycosyl Hydrolase Family 88 BIS30_14130 ENOG41075H3 AraC family transcriptional regulator BIS30_14135 ENOG4107TDE lipolytic protein G-D-S-L family BIS30_14150 ENOG4105CX8 fg-gap repeat protein BIS30_14155 ENOG4105CX8 fg-gap repeat protein BIS30_14160 ENOG4107TDE lipolytic protein G-D-S-L family BIS30_14170 ENOG4105EKC BIS30_14175 ENOG4105E0S extracellular solute-binding protein family 1 BIS30_14185 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BIS30_14190 ENOG4105F8D glycoside hydrolase family 4 BIS30_14195 ENOG4105H67 Protein of unknown function (DUF421) BIS30_14200 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BIS30_14205 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BIS30_14225 ENOG4106I4J membrane BIS30_14230 ENOG41082F9 transcriptional regulator BIS30_14235 ENOG41061H0 Monooxygenase BIS30_14240 ENOG4108R1P BIS30_14245 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BIS30_14250 ENOG4105E0M Sulfatase BIS30_14255 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BIS30_14265 ENOG41090R9 glycosyltransferase BIS30_14270 ENOG4107R51 Glycosyl transferase, family 2 BIS30_14275 ENOG41090R9 glycosyltransferase BIS30_14280 ENOG4105EU0 Major facilitator Superfamily BIS30_14290 ENOG4105CUB amino acid BIS30_14295 ENOG4105C26 Dehydrogenase BIS30_14300 ENOG4105FKZ Methyl-accepting chemotaxis BIS30_14305 ENOG4105C5H ABC transporter BIS30_14315 ENOG4107SWG transcriptional regulator MERR family BIS30_14320 ENOG4105DXB Major Facilitator superfamily BIS30_14335 ENOG4105C5H ABC transporter BIS30_14340 ENOG4105FDU atp-dependent rna helicase BIS30_14350 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BIS30_14355 ENOG4105E0A ABC, transporter BIS30_14360 ENOG4108U1V ABC transporter, permease BIS30_14365 ENOG4105DQ5 transport system permease protein BIS30_14370 ENOG4108HUF Transporter BIS30_14385 ENOG4108J20 pectate lyase BIS30_14390 ENOG4107QPK )-transporter BIS30_14400 ENOG4108MRH transcriptional regulatory protein BIS30_14425 ENOG410855V Acylphosphatase BIS30_14430 ENOG4108RPX mosc domain containing protein BIS30_14450 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BIS30_14475 ENOG4105GEU Spore germination protein BIS30_14485 ENOG4108Q5U germination protein, ger(x)c family BIS30_14490 ENOG4105E1K spore germination protein BIS30_14495 ENOG4105C5Y PTS System BIS30_14500 ENOG4105CG3 alpha amylase, catalytic region BIS30_14505 ENOG4107414 GntR family transcriptional regulator BIS30_14510 ENOG4108RCM Nitroreductase BIS30_14515 ENOG4105CGH 5'-nucleotidase BIS30_14520 ENOG4107RKG DJ-1/PfpI family BIS30_14535 ENOG4105KJF protein tyrosine phosphatase BIS30_14545 ENOG4107U9T Pfam:Ribonuclease_BN BIS30_14555 ENOG4108ISG Major Facilitator BIS30_14565 ENOG4105UPD Calcium Proton BIS30_14575 ENOG4105D8X mechanosensitive ion channel BIS30_14595 ENOG4106KE4 Dehydrogenase BIS30_14600 ENOG4105D7N magnesium and cobalt transport protein CorA BIS30_14615 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BIS30_14625 ENOG4105KNA -acetyltransferase BIS30_14640 ENOG4107RUY (E1 component), alpha subunit BIS30_14660 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BIS30_14665 ENOG41069DP small acid-soluble spore protein BIS30_14670 ENOG4105KK4 UPF0060 membrane protein BIS30_14695 ENOG4105F8D glycoside hydrolase family 4 BIS30_14700 ENOG4108Q3X Transcriptional regulator BIS30_14705 ENOG4105CI1 PTS System BIS30_14715 ENOG4105BZ1 (ABC) transporter BIS30_14725 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BIS30_14730 ENOG4105BZU Histidine kinase BIS30_14735 ENOG4105WH1 Two component transcriptional regulator luxr family BIS30_14740 ENOG4105CJ1 ABC, transporter BIS30_14745 ENOG41090VJ ABC-2 type transporter BIS30_14750 ENOG4108KYE ABC-2 type transporter BIS30_14760 ENOG4105U3E Transcriptional regulator BIS30_14765 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BIS30_14770 ENOG4105H93 Acyltransferase family BIS30_14775 ENOG4108YYS metal-dependent hydrolase (By similarity) BIS30_14780 ENOG4105C0R drug resistance transporter emrb qaca subfamily BIS30_14785 ENOG410834F Transcriptional regulator BIS30_14795 ENOG4108MES Periplasmic binding protein BIS30_14800 ENOG4105DQ5 transport system permease protein BIS30_14805 ENOG4108IHU transport system permease protein BIS30_14815 ENOG4107Y03 Nitroreductase BIS30_14830 ENOG4105ECP epimerase BIS30_14850 ENOG4105F27 Major Facilitator BIS30_14870 ENOG4106AKJ BIS30_14875 ENOG4105D74 hydrolase BIS30_14880 ENOG4105CKK Glycosyl transferase, family 2 BIS30_14885 ENOG4105EJV Membrane BIS30_14890 ENOG41067AE Membrane-bound metal-dependent hydrolase BIS30_14895 ENOG4105CEN a g-specific adenine glycosylase BIS30_14900 ENOG4106BXE BIS30_14905 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BIS30_14920 ENOG4105EVI UPF0374 protein BIS30_14925 ENOG4105BZ1 (ABC) transporter BIS30_14930 ENOG4107NBY Membrane BIS30_14940 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BIS30_14945 ENOG4105G5W regulator Fur family BIS30_15065 ENOG4108N23 SpoOM-related protein BIS30_15080 ENOG4105EC3 peptidase S51, dipeptidase E BIS30_15085 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BIS30_15100 ENOG4105E2Y ABC, transporter BIS30_15105 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BIS30_15110 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BIS30_15115 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BIS30_15125 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BIS30_15130 ENOG4107D63 BIS30_15135 ENOG4105VZ8 Transcriptional regulator BIS30_15150 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BIS30_15160 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BIS30_15180 ENOG4105CYN Serine protein kinase BIS30_15185 ENOG4106AKX UPF0229 protein BIS30_15190 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BIS30_15195 ENOG4105CW7 secretion protein, HlyD family BIS30_15200 ENOG4105C0R drug resistance transporter emrb qaca subfamily BIS30_15205 ENOG4105CS1 NAD(P)H quinone oxidoreductase BIS30_15220 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BIS30_15225 ENOG4105CZV ABC transporter BIS30_15230 ENOG4105CJ1 ABC, transporter BIS30_15240 ENOG4105VEQ Cold shock protein BIS30_15250 ENOG4105BZU Histidine kinase BIS30_15290 ENOG4108YBP pseudouridine synthase BIS30_15300 ENOG41080XP Cbs domain BIS30_15305 ENOG4107YBY Hydrolase BIS30_15310 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BIS30_15320 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BIS30_15325 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BIS30_15335 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BIS30_15340 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BIS30_15350 ENOG4105BZU Histidine kinase BIS30_15355 ENOG4105WH1 Two component transcriptional regulator luxr family BIS30_15390 ENOG4105ED1 spovr family BIS30_15395 ENOG4105G6Z alkaline phosphatase BIS30_15410 ENOG4105BZN citrate synthase BIS30_15415 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BIS30_15420 ENOG4105CUB amino acid BIS30_15425 ENOG4105C8J )-transporter BIS30_15430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BIS30_15445 ENOG4105J37 BIS30_15450 ENOG4108AEY RNA polymerase sigma factor BIS30_15455 ENOG4108FN7 Aldo keto reductase BIS30_15460 ENOG4105F6E Acyl-transferase BIS30_15465 ENOG4107VFR oxidoreductase BIS30_15475 ENOG4105C37 (CBS) domain BIS30_15485 ENOG4105CHM Aminotransferase BIS30_15490 ENOG4105C37 (CBS) domain BIS30_15500 ENOG4105WMR Protein CrcB homolog BIS30_15505 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BIS30_15515 ENOG4105D64 Mechanosensitive ion channel BIS30_15520 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BIS30_15525 ENOG4107VMI polysaccharide deacetylase BIS30_15530 ENOG4105F0I Aminotransferase BIS30_15550 ENOG4105BZ1 (ABC) transporter BIS30_15555 ENOG4105BZ1 (ABC) transporter BIS30_15590 ENOG4106MP8 UPF0754 membrane protein BIS30_15595 ENOG4105WZB UPF0342 protein BIS30_15600 ENOG4105F1N DNA alkylation repair BIS30_15610 ENOG4105D4P Coproporphyrinogen iii oxidase BIS30_15615 ENOG4107S91 Sodium hydrogen exchanger BIS30_15620 ENOG4105NCW Trka-c domain protein BIS30_15630 ENOG4105CGU Enoyl-CoA hydratase BIS30_15640 ENOG4108IUX (ABC) transporter BIS30_15645 ENOG4105RHA ABC transporter, permease BIS30_15650 ENOG4107VRP DNA repair exonuclease BIS30_15655 ENOG4106D4I domain protein BIS30_15660 ENOG4105EQI Metal Dependent Phosphohydrolase BIS30_15670 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BIS30_15710 ENOG4105NBU tryptophan transport protein BIS30_15715 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BIS30_15720 ENOG4105K59 histidine triad (HIT) protein BIS30_15755 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BIS30_15760 ENOG4105BZ4 penicillin-binding protein BIS30_15765 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BIS30_15770 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BIS30_15775 ENOG4105C1Q protoporphyrinogen oxidase BIS30_15785 ENOG4105ECB domain protein BIS30_15795 ENOG41090T1 Membrane BIS30_15805 ENOG4105DER m42 family BIS30_15820 ENOG4106AXD BIS30_15825 ENOG4108RQ5 Beta-lactamase domain-containing protein BIS30_15830 ENOG4105DF9 Lipoate-protein, ligase BIS30_15840 ENOG4105CEY Amp-dependent synthetase and ligase BIS30_15850 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BIS30_15860 ENOG4105KD7 acetyltransferase BIS30_15870 ENOG4108HUF Transporter BIS30_15875 ENOG4107TB6 phosphoglycerate mutase BIS30_15885 ENOG4107F3J Amp-dependent synthetase and ligase BIS30_15890 ENOG4107ZYJ bioY protein BIS30_15895 ENOG4106YBV Methyl-accepting chemotaxis BIS30_15915 ENOG4105XVF Competence transcription factor BIS30_15920 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BIS30_15925 ENOG4105X3H Excalibur domain protein BIS30_15930 ENOG4105E1V na solute symporter BIS30_15935 ENOG4106CAD Protein of unknown function (DUF3311) BIS30_15940 ENOG41060YP BIS30_15955 ENOG4107SCK Monooxygenase BIS30_15960 ENOG4108INS Transcriptional regulator BIS30_15980 ENOG4105TRI Hydrolase BIS30_15995 ENOG4108KK1 membrane protein AbrB duplication BIS30_16000 ENOG4106K7D Major facilitator family transporter BIS30_16005 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BIS30_16010 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding BIS30_16025 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BIS30_16035 ENOG4105EYH Exonuclease BIS30_16085 ENOG4105ERH Fumarylacetoacetate hydrolase BIS30_16095 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BIS30_16105 ENOG4105CAQ asparagine synthetase BIS30_16120 ENOG4105UQX Mate efflux family protein BIS30_16125 ENOG4106HBX Transcriptional Regulator AraC Family BIS30_16130 ENOG4105ETE Transcriptional regulator (LacI family BIS30_16135 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BIS30_16140 ENOG4105SF0 DinB family BIS30_16145 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BIS30_16150 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BIS30_16155 ENOG4105MYW Pentapeptide repeat protein BIS30_16160 ENOG4107S9D Alpha beta hydrolase BIS30_16165 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BIS30_16170 ENOG4107RIQ Sulfate adenylate transferase BIS30_16175 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BIS30_16180 ENOG4108N5B 2-phosphosulfolactate phosphatase BIS30_16185 ENOG41061P3 phosphosulfolactate synthase BIS30_16195 ENOG4105DIA mandelate racemase muconate lactonizing BIS30_16200 ENOG4107RCC Major Facilitator Superfamily BIS30_16205 ENOG4108SZE gCN5-related N-acetyltransferase BIS30_16210 ENOG4105MA6 gCN5-related N-acetyltransferase BIS30_16220 ENOG4108VPT UPF0234 protein BIS30_16225 ENOG4105QNR S1 RNA binding domain protein BIS30_16230 ENOG410751J BIS30_16235 ENOG4105EPR degv family BIS30_16240 ENOG4107AYK membrAne BIS30_16250 ENOG41073B9 BIS30_16260 ENOG4108KP7 hydrolase BIS30_16265 ENOG4108MXZ Esterase BIS30_16270 ENOG4105VG1 fes assembly suf system protein BIS30_16280 ENOG4105IQ5 FAD linked oxidase domain protein BIS30_16290 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BIS30_16305 ENOG4105C8Y Acetylornithine aminotransferase BIS30_16310 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BIS30_16320 ENOG4105DBV ornithine carbamoyltransferase BIS30_16345 ENOG4107RMD Basic membrane lipoprotein BIS30_16365 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BIS30_16375 ENOG4105C3U ABC transporter BIS30_16380 ENOG4108JQ7 (ABC) transporter BIS30_16395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BIS30_16405 ENOG4105C31 Tryptophanyl-tRNA synthetase BIS30_16410 ENOG4108J59 Extracellular solute-binding protein, family 5 BIS30_16415 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BIS30_16420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BIS30_16430 ENOG4108JQ7 (ABC) transporter BIS30_16445 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BIS30_16450 ENOG4108ZCF integral membrane protein BIS30_16455 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BIS30_16465 ENOG4105DPN Oligoendopeptidase f BIS30_16480 ENOG4105T58 Dithiol-disulfide isomerase BIS30_16485 ENOG4108Z18 K06886 hemoglobin BIS30_16490 ENOG4105E4C Lytic transglycosylase catalytic BIS30_16495 ENOG4105MIX Adenylate cyclase BIS30_16510 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BIS30_16515 ENOG4105EMS pseudouridine synthase BIS30_16530 ENOG4105ETU transcriptional activator (TenA BIS30_16550 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BIS30_16555 ENOG4105D06 uba thif-type nad fad binding protein BIS30_16560 ENOG4105DWF phosphomethylpyrimidine kinase BIS30_16565 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BIS30_16570 ENOG4107A88 BIS30_16625 ENOG4105ENA helicase BIS30_16640 ENOG4108ZMI UPF0477 protein BIS30_16650 ENOG4105C28 cystathionine BIS30_16655 ENOG4105C28 cystathionine BIS30_16665 ENOG4105JHY Membrane BIS30_16720 ENOG4105DM4 PTS System BIS30_16725 ENOG4105DG6 mannose-6-phosphate isomerase BIS30_16745 ENOG4108Z66 YbaK ebsC protein BIS30_16765 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BIS30_16775 ENOG4108ZJ4 polysaccharide deacetylase BIS30_16780 ENOG4107CUJ Protein of unknown function (DUF2690) BIS30_16810 ENOG4108IEG Formate dehydrogenase Alpha subunit BIS30_16835 ENOG4106A3M Cytochrome p-450 BIS30_16840 ENOG41087PP glycosyltransferase MGT family BIS30_16850 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BIS30_16855 ENOG4105C4B ABC transporter, permease BIS30_16860 ENOG4108IXI (ABC) transporter BIS30_16870 ENOG4105Q95 Cupin 2, conserved barrel domain protein BIS30_16885 ENOG4105D2H Uronic isomerase BIS30_16890 ENOG4105CT4 transporter BIS30_16895 ENOG4105DG4 malate L-lactate dehydrogenase BIS30_16900 ENOG4105CPQ Dehydrogenase BIS30_16905 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BIS30_16910 ENOG4105DMW Dehydrogenase reductase BIS30_16915 ENOG4108I5G Major Facilitator superfamily BIS30_16920 ENOG4107KJX Transcriptional regulator BIS30_16925 ENOG4107QZW Altronate oxidoreductase BIS30_16930 ENOG4105CTX dehydratase BIS30_16935 ENOG4107TSN permease BIS30_16945 ENOG4105JD4 ATPase yjob BIS30_16960 ENOG41068K0 YCII-related domain BIS30_16965 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BIS30_16970 ENOG4105KWG Pfam:DUF1696 BIS30_16975 ENOG4105K7W phage-related replication protein BIS30_16980 ENOG4105WEF catalase BIS30_16985 ENOG410635T phage-like element pbsx protein BIS30_17035 ENOG4108TFU terminase (Small subunit) BIS30_17045 ENOG4108MDF Phage Portal Protein BIS30_17070 ENOG41060SN BIS30_17085 ENOG4105PQS phage protein BIS30_17095 ENOG4105MTC XkdN-like protein BIS30_17105 ENOG4108FKH Transglycosylase SLT domain BIS30_17105 ENOG4108FKH Transglycosylase SLT domain BIS30_17105 ENOG4108FKH Transglycosylase SLT domain BIS30_17110 ENOG4108WZM domain protein BIS30_17115 ENOG4105X7F BIS30_17125 ENOG4105MFU Protein of unknown function (DUF2634) BIS30_17130 ENOG41066EA baseplate J family protein BIS30_17135 ENOG410906S phage-like element pbsx protein xkdt BIS30_17145 ENOG41068G1 BIS30_17175 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BIS30_17190 ENOG4105CJ3 phosphate transporter BIS30_17195 ENOG4107GRR phosphate transport regulator BIS30_17200 ENOG4107R7I amino acid BIS30_17215 ENOG4105CKK Glycosyl transferase, family 2 BIS30_17225 ENOG4105C0H protease BIS30_17235 ENOG4108ME1 Peptidase M55 D-aminopeptidase BIS30_17240 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BIS30_17245 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BIS30_17250 ENOG4105C3U ABC transporter BIS30_17260 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BIS30_17265 ENOG4105DTQ mandelate racemase muconate lactonizing BIS30_17270 ENOG4107SN7 NLP P60 protein BIS30_17275 ENOG4108JQ7 (ABC) transporter BIS30_17280 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BIS30_17285 ENOG4107TUM Amidinotransferase BIS30_17290 ENOG4108S4H thioesterase Superfamily protein BIS30_17295 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BIS30_17315 ENOG4108428 Inherit from COG: -acetyltransferase BIS30_17325 ENOG41080TC multidrug resistance protein BIS30_17330 ENOG4105CIY formyltetrahydrofolate deformylase BIS30_17335 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BIS30_17350 ENOG4105K56 Transcriptional regulator BIS30_17355 ENOG4108ZHJ Organic hydroperoxide resistance protein BIS30_17360 ENOG4107TVC Glycosyl transferase, family 2 BIS30_17365 ENOG4107Y2X deaminase BIS30_17375 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BIS30_17380 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BIS30_17390 ENOG4108W7F transporter, permease BIS30_17395 ENOG4108JJB ABC transporter BIS30_17400 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BIS30_17405 ENOG4108X43 YKOF domain protein BIS30_17410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BIS30_17415 ENOG41062D9 Histidine kinase BIS30_17425 ENOG4106849 propeptide, pepSY amd peptidase M4 BIS30_17440 ENOG4105CJW magnesium transporter BIS30_17445 ENOG4105V75 Transcriptional regulator BIS30_17490 ENOG4105DQE DNA ligase BIS30_17495 ENOG4105FDF Could be involved in DNA repair (By similarity) BIS30_17500 ENOG4105BZU Histidine kinase BIS30_17505 ENOG4107T5V SNARE associated Golgi BIS30_17510 ENOG4107TS3 membrane protein, TerC BIS30_17515 ENOG4108WZW RNA polymerase sigma BIS30_17525 ENOG410681C small acid-soluble spore protein BIS30_17535 ENOG4105D0M Protease HtpX homolog BIS30_17555 ENOG4108TGC Acyltransferase BIS30_17560 ENOG4105BZU Histidine kinase BIS30_17565 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BIS30_17575 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BIS30_17580 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BIS30_17585 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BIS30_17595 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit BIS30_17600 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BIS30_17605 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BIS30_17610 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BIS30_17630 ENOG4105BZU Histidine kinase BIS30_17635 ENOG41090MY MarR family Transcriptional regulator BIS30_17640 ENOG4105ER2 Ompa motb domain protein BIS30_17645 ENOG4105E14 MotA TolQ exbB proton channel BIS30_17655 ENOG4108K88 Membrane BIS30_17660 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BIS30_17665 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BIS30_17670 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BIS30_17675 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BIS30_17705 ENOG4105F0V Cell wall hydrolase BIS30_17720 ENOG4105C59 p-type ATPase BIS30_17730 ENOG4105DC7 peptidase M24 BIS30_17745 ENOG4105CID antiterminator BIS30_17755 ENOG4105KRI phosphocarrier protein (HPr BIS30_17760 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BIS30_17770 ENOG4105F6S Spore photoproduct lyase BIS30_17780 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BIS30_17785 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BIS30_17790 ENOG4105K4I Scp-like extracellular BIS30_17800 ENOG4105BZU Histidine kinase BIS30_17805 ENOG4105CHM Aminotransferase BIS30_17815 ENOG4107R88 Chemotaxis protein (CheV) BIS30_17820 ENOG4105UIN BIS30_17830 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BIS30_17840 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BIS30_17845 ENOG4105EPM Diguanylate phosphodiesterase BIS30_17850 ENOG4107IN1 Protein of unknown function (DUF1797) BIS30_17855 ENOG4108XRC Protein of unknown function (DUF458) BIS30_17885 ENOG4105NQC Flavodoxin BIS30_17895 ENOG4105CH2 amidohydrolase BIS30_17905 ENOG4105D8X mechanosensitive ion channel BIS30_17910 ENOG4105D3R alkyl hydroperoxide reductase BIS30_17915 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BIS30_17930 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BIS30_17935 ENOG4105D06 uba thif-type nad fad binding protein BIS30_17940 ENOG4105CVM Molybdenum cofactor synthesis domain protein BIS30_17945 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BIS30_17950 ENOG4108ZAF Molybdopterin BIS30_17955 ENOG41067WU Molybdopterin converting factor (Subunit 1) BIS30_17960 ENOG4105BZ1 (ABC) transporter BIS30_17965 ENOG4105BZ1 (ABC) transporter BIS30_17975 ENOG4107X8C Efflux transporter RND family MFP subunit BIS30_17980 ENOG4105C19 ABC transporter BIS30_17985 ENOG4107RBB ABC transporter, permease BIS30_17990 ENOG4105E98 transcriptional regulator DeoR family BIS30_17995 ENOG4105DE4 1-phosphofructokinase BIS30_18000 ENOG4105DM4 PTS System BIS30_18005 ENOG4105DQ6 Transposase BIS30_18015 ENOG4105C3F Signal peptidase i BIS30_18025 ENOG4105C5H ABC transporter BIS30_18030 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BIS30_18055 ENOG4105BZU Histidine kinase BIS30_18065 ENOG4107ZYR domain protein BIS30_18075 ENOG4105CN5 Metallo-Beta-Lactamase BIS30_18085 ENOG4108X4Q Hydrolase BIS30_18090 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BIS30_18110 ENOG4105CPP Dehydrogenase, E1 component BIS30_18115 ENOG4105C7S Dehydrogenase BIS30_18120 ENOG4107QN2 dihydrolipoyl dehydrogenase BIS30_18135 ENOG4105DQ6 Transposase BIS30_18140 ENOG4105CXN decarboxylase BIS30_18145 ENOG4105WBI UPF0223 protein BIS30_18160 ENOG4105ECY inositol monophosphatase BIS30_18170 ENOG4105JQZ Methyltransferase BIS30_18210 ENOG4105CI3 gtp-binding protein typa BIS30_18215 ENOG4105QA2 BIS30_18230 ENOG4108IAB Phoh family BIS30_18240 ENOG4105CSV Glutaminase BIS30_18245 ENOG4105ZPI UPF0358 protein BIS30_18250 ENOG4105CNI cell division protein FtsW BIS30_18255 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BIS30_18265 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BIS30_18275 ENOG4105BZ9 Cytochrome C oxidase, subunit I BIS30_18280 ENOG4105CCU oxidase (Subunit III) BIS30_18285 ENOG41064X9 cytochrome C oxidase subunit IV BIS30_18300 ENOG41080XQ Signal transduction protein with cbs domains BIS30_18305 ENOG4106UY4 Inherit from COG: Scp-like extracellular BIS30_18325 ENOG4105WUC UPF0298 protein BIS30_18330 ENOG4106H78 methyltransferase BIS30_18335 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BIS30_18340 ENOG4105H20 Sporulation integral membrane protein YlbJ BIS30_18345 ENOG4105D78 K07001 NTE family protein BIS30_18350 ENOG41063PX domain protein BIS30_18355 ENOG4105CDE UPF0348 protein BIS30_18360 ENOG4105KNH Nucleic acid-binding protein BIS30_18365 ENOG41067VY 50S ribosomal protein L32 BIS30_18390 ENOG4108V6E Cell division protein mraZ BIS30_18395 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BIS30_18405 ENOG4105CJN penicillin-binding protein BIS30_18415 ENOG4105CJN penicillin-binding protein BIS30_18425 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BIS30_18435 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BIS30_18440 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BIS30_18445 ENOG4105CNI cell division protein FtsW BIS30_18450 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BIS30_18455 ENOG4105D4A Cell wall formation (By similarity) BIS30_18460 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BIS30_18465 ENOG4108R2U division initiation protein BIS30_18475 ENOG4105K67 small basic protein BIS30_18480 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BIS30_18485 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BIS30_18495 ENOG4105FFI sigma-e processing peptidase spoiiga BIS30_18500 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIS30_18510 ENOG4105DKW ABC transporter BIS30_18520 ENOG4105WR5 sporulation protein, YlmC YmxH family BIS30_18525 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BIS30_18530 ENOG4105DFA alanine racemase domain protein BIS30_18535 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BIS30_18540 ENOG41067XK integral membrane protein BIS30_18545 ENOG4105DBK s4 domain protein BIS30_18555 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BIS30_18565 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BIS30_18570 ENOG4105C34 Pseudouridine synthase BIS30_18575 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BIS30_18585 ENOG4105CXT aspartate transcarbamylase BIS30_18595 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BIS30_18600 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BIS30_18605 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BIS30_18610 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BIS30_18615 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BIS30_18620 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BIS30_18630 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BIS30_18640 ENOG4107S4M Sulfate adenylate transferase BIS30_18645 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BIS30_18650 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BIS30_18655 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BIS30_18660 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BIS30_18665 ENOG4105F23 Fibronectin-binding protein BIS30_18675 ENOG4105DSJ YicC domain protein BIS30_18680 ENOG4105KC4 UPF0296 protein BIS30_18685 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BIS30_18695 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BIS30_18700 ENOG4105C25 Primosomal protein n' BIS30_18705 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BIS30_18710 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BIS30_18715 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BIS30_18720 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BIS30_18725 ENOG4108ZF3 Phosphatase BIS30_18730 ENOG4105D9P serine threonine protein kinase BIS30_18735 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BIS30_18740 ENOG4105DJV ribulose-phosphate 3-epimerase BIS30_18745 ENOG4105FJ0 thiamine BIS30_18755 ENOG4105VB9 50S ribosomal protein l28 BIS30_18760 ENOG4108ZAA Alkaline-shock protein BIS30_18765 ENOG4105DP4 dak2 domain fusion protein ylov BIS30_18775 ENOG4105EJQ L-serine dehydratase BIS30_18780 ENOG4105CB5 ATP-dependent DNA helicase recG BIS30_18785 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BIS30_18795 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BIS30_18800 ENOG4105CHR reductase BIS30_18805 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BIS30_18810 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BIS30_18815 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BIS30_18820 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BIS30_18830 ENOG4105DQ6 Transposase BIS30_18840 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BIS30_18850 ENOG4105K5M 30s ribosomal protein S16 BIS30_18855 ENOG4108BW8 UPF0109 protein BIS30_18865 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BIS30_18870 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BIS30_18875 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BIS30_18885 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BIS30_18895 ENOG4105VM1 flagellar BIS30_18900 ENOG4105CMV Succinyl-CoA synthetase subunit beta BIS30_18905 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BIS30_18910 ENOG4105C79 DNA protecting protein DprA BIS30_18915 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BIS30_18920 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BIS30_18925 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BIS30_18930 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BIS30_18945 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BIS30_18950 ENOG4108ZC9 flagellar basal-body rod protein flgc BIS30_18955 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BIS30_18960 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BIS30_18965 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BIS30_18980 ENOG4106YF4 Flagellar biosynthesis chaperone BIS30_18990 ENOG410696Y Flagellar hook-length control protein BIS30_18995 ENOG410822I Flagellar hook capping protein BIS30_19000 ENOG4108JQA flagellar BIS30_19005 ENOG41068WV flagellar FlbD family protein BIS30_19015 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BIS30_19020 ENOG4105DD5 Flagellar motor switch protein BIS30_19025 ENOG4107YTP response regulator receiver protein BIS30_19035 ENOG4105CN7 Flagellar biosynthetic protein FliP BIS30_19045 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BIS30_19050 ENOG4105D00 flagellar biosynthetic protein flhB BIS30_19055 ENOG4105D7B Flagellar biosynthesis protein flha BIS30_19060 ENOG4105FZW flagellar biosynthesis regulator FlhF BIS30_19070 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BIS30_19075 ENOG4105CBS Chea signal transduction histidine kinase BIS30_19080 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BIS30_19095 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIS30_19110 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BIS30_19120 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BIS30_19125 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BIS30_19130 ENOG4105KNE Phosphatidate cytidylyltransferase BIS30_19140 ENOG4105DZP Membrane-associated zinc metalloprotease BIS30_19145 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BIS30_19150 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BIS30_19155 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BIS30_19160 ENOG4105CHV Transcription elongation factor NusA BIS30_19165 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BIS30_19170 ENOG4105VHM ribosomal protein BIS30_19175 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BIS30_19180 ENOG4105W7A Protein of unknown function (DUF503) BIS30_19185 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BIS30_19190 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BIS30_19195 ENOG4105DTN riboflavin biosynthesis protein ribF BIS30_19200 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BIS30_19205 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BIS30_19215 ENOG4105C1V Peptidase, M16 BIS30_19225 ENOG4105E35 Dipicolinate synthase subunit A BIS30_19230 ENOG4108S0H Dipicolinic acid synthetase, b subunit BIS30_19235 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BIS30_19245 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BIS30_19255 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BIS30_19265 ENOG4105CNU cell division protein FtsK BIS30_19270 ENOG4105FDP GntR family transcriptional regulator BIS30_19290 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BIS30_19295 ENOG4105XZV Protein of unknown function (DUF3243) BIS30_19310 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BIS30_19315 ENOG4105CEV competence damage-inducible protein BIS30_19325 ENOG4108A04 Beta-lactamase BIS30_19330 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BIS30_19335 ENOG4105D48 metallophosphoesterase BIS30_19340 ENOG4105MCT stage V sporulation protein S BIS30_19350 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BIS30_19355 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BIS30_19370 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BIS30_19375 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BIS30_19395 ENOG4105IIP Membrane BIS30_19400 ENOG4105W1N transcriptional regulator BIS30_19405 ENOG4108151 Beta-lactamase domain protein BIS30_19415 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BIS30_19425 ENOG4107QKG PfaD family BIS30_19430 ENOG41062T2 Acyl carrier protein BIS30_19435 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase BIS30_19440 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BIS30_19445 ENOG4108MGH Enoyl-CoA hydratase BIS30_19450 ENOG4108KQ6 Enoyl-CoA hydratase BIS30_19455 ENOG4105C0W non-ribosomal peptide synthetase BIS30_19480 ENOG4106A3M Cytochrome p-450 BIS30_19495 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BIS30_19505 ENOG4105K7W phage-related replication protein BIS30_19510 ENOG4108X3M OsmC Ohr family protein BIS30_19520 ENOG4105DQ6 Transposase BIS30_19545 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BIS30_19550 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BIS30_19565 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BIS30_19570 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BIS30_19575 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BIS30_19580 ENOG4105U6W MutT NUDIX family protein BIS30_19585 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BIS30_19595 ENOG4106F1P AAA ATPase, central domain protein BIS30_19605 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BIS30_19610 ENOG4105CXI aluminum resistance protein BIS30_19615 ENOG4105KV4 Transcriptional regulator BIS30_19620 ENOG4105C5F glutamine synthetase BIS30_19635 ENOG4105CT4 transporter BIS30_19640 ENOG4105DSG hydrolase family 43 BIS30_19655 ENOG4105CMG Carbohydrate kinase BIS30_19670 ENOG4105C54 Major Facilitator superfamily BIS30_19675 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BIS30_19685 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BIS30_19750 ENOG4105FVX BIS30_19760 ENOG4105K7W phage-related replication protein BIS30_19770 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BIS30_19785 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BIS30_19795 ENOG4108SVB resolvase BIS30_19800 ENOG4105VPS UPF0291 protein BIS30_19805 ENOG4105CV1 Transketolase (EC 2.2.1.1) BIS30_19825 ENOG4107QIV Cytochrome c biogenesis protein BIS30_19850 ENOG4107DZX Small, acid-soluble spore protein P BIS30_19860 ENOG4108I0Z Aconitate hydratase BIS30_19865 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BIS30_19880 ENOG41067CD Small, acid-soluble spore protein Tlp BIS30_19890 ENOG4105MI2 BIS30_19895 ENOG4105W8X HesB YadR YfhF-family protein BIS30_19900 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BIS30_19905 ENOG4105K4P CoA-binding domain protein BIS30_19910 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BIS30_19935 ENOG4107QWR cellulase (EC 3.2.1.4) BIS30_19950 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BIS30_19985 ENOG4107QX3 carboxylase BIS30_19990 ENOG4105E39 Enoyl-CoA hydratase BIS30_19995 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BIS30_20000 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BIS30_20005 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BIS30_20010 ENOG4105CEY Amp-dependent synthetase and ligase BIS30_20015 ENOG4105C1G acyl-Coa dehydrogenase BIS30_20030 ENOG4105F32 YngK protein BIS30_20035 ENOG4106U2H Protein of unknown function (DUF1360) BIS30_20060 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BIS30_20065 ENOG4108N2V aldose 1-epimerase BIS30_20070 ENOG4107QJQ Mate efflux family protein BIS30_20095 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BIS30_20115 ENOG41068G1 BIS30_20125 ENOG410651K Teichoic acid biosynthesis protein C BIS30_20130 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase BIS30_20355 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BIS30_20360 ENOG4105SKE transcriptional Regulator LysR family BIS30_20370 ENOG4105BZ8 glutamate synthase BIS30_20375 ENOG4105CBC glutamate synthase BIS30_20380 ENOG4105C5Q Transcriptional regulator BIS30_20385 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BIS30_20415 ENOG4108UB7 BIS30_20420 ENOG41068WN BIS30_20445 ENOG4105IE8 Alpha-ketoglutarate permease BIS30_20450 ENOG4107U6E carbohydrate kinase FGGY BIS30_20460 ENOG4108J2R molybdopterin oxidoreductase BIS30_20490 ENOG4105EC8 Methyl-accepting chemotaxis BIS30_20500 ENOG4108YQE rare lipoprotein a BIS30_20505 ENOG4105XPP Protein of unknown function (DUF1275) BIS30_20510 ENOG4108NR7 pectate lyase BIS30_20515 ENOG4105CHR reductase BIS30_20530 ENOG4108RAV Conserved protein BIS30_20570 ENOG41073R8 VanW family BIS30_20580 ENOG4105VMP Transcriptional regulator BIS30_20585 ENOG4105NX3 Membrane BIS30_20620 ENOG4108V4B ThiJ pfpI BIS30_20625 ENOG4108J4B Beta-lactamase BIS30_20635 ENOG4108M1A Chitin-binding protein BIS30_20660 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BIS30_20665 ENOG4108SHN Glycosyl transferase, family 2