locus-tag	class	description
BIS30_00030	COG4974	Belongs to the 'phage' integrase family
BIS30_00045	COG2273	Hydrolase Family 16
BIS30_00050	COG4282	regulation of fungal-type cell wall biogenesis
BIS30_00055	COG1231	oxidoreductase activity
BIS30_00060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIS30_00065	COG2207	Transcriptional regulator
BIS30_00065	COG0662	Cupin 2, conserved barrel domain protein
BIS30_00070	COG0456	acetyltransferase
BIS30_00080	COG1309	transcriptional regulator
BIS30_00090	COG3708	Transcriptional regulator
BIS30_00095	COG2378	regulation of single-species biofilm formation
BIS30_00105	COG0640	Transcriptional regulator
BIS30_00110	COG0741	lytic transglycosylase activity
BIS30_00115	COG2322	membrane
BIS30_00130	COG1619	proteins homologs of microcin C7 resistance protein MccF
BIS30_00135	COG3239	Fatty acid desaturase
BIS30_00140	COG4585	Histidine kinase
BIS30_00145	COG2197	response regulator
BIS30_00150	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_00155	COG3584	3D domain protein
BIS30_00155	COG1388	LysM domain
BIS30_00160	COG0514	ATP-dependent DNA helicase (RecQ)
BIS30_00165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BIS30_00185	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_00190	COG1657	PFAM Prenyltransferase squalene oxidase
BIS30_00195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BIS30_00200	COG0733	neurotransmitter:sodium symporter activity
BIS30_00205	COG0385	Bile acid
BIS30_00210	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIS30_00215	COG0567	Dehydrogenase, E1 component
BIS30_00220	COG4548	von Willebrand factor, type A
BIS30_00225	COG0714	Associated with various cellular activities
BIS30_00230	COG2032	superoxide dismutase activity
BIS30_00235	COG0791	NLP P60 protein
BIS30_00235	COG1388	LysM domain
BIS30_00240	COG1819	glycosyl
BIS30_00245	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BIS30_00250	COG0534	Mate efflux family protein
BIS30_00255	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_00260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BIS30_00265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BIS30_00275	COG2962	Rard protein
BIS30_00290	COG1942	4-Oxalocrotonate Tautomerase
BIS30_00295	COG1733	regulation of RNA biosynthetic process
BIS30_00300	COG0778	Nitroreductase
BIS30_00305	COG0400	carboxylic ester hydrolase activity
BIS30_00320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_00325	COG0793	Belongs to the peptidase S41A family
BIS30_00325	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_00330	COG2226	methyltransferase
BIS30_00340	COG1876	peptidase activity
BIS30_00345	COG0813	purine-nucleoside phosphorylase activity
BIS30_00360	COG0671	phosphoesterase, PA-phosphatase related
BIS30_00380	COG4479	Belongs to the UPF0346 family
BIS30_00390	COG1509	lysine 2,3-aminomutase activity
BIS30_00395	COG0456	acetyltransferase
BIS30_00400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIS30_00405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BIS30_00410	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BIS30_00430	COG0456	acetyltransferase
BIS30_00450	COG4641	Protein conserved in bacteria
BIS30_00455	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
BIS30_00460	COG1086	Polysaccharide biosynthesis protein
BIS30_00465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIS30_00470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIS30_00475	COG1846	Transcriptional regulator
BIS30_00480	COG0534	Mate efflux family protein
BIS30_00490	COG4698	Protein conserved in bacteria
BIS30_00495	COG2755	lipolytic protein G-D-S-L family
BIS30_00500	COG1999	signal sequence binding
BIS30_00515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BIS30_00520	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BIS30_00525	COG1272	protein, Hemolysin III
BIS30_00530	COG0204	Acyl-transferase
BIS30_00535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIS30_00545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BIS30_00555	COG2136	Putative SAM-dependent methyltransferase
BIS30_00555	COG2521	methyltransferase
BIS30_00565	COG0129	dihydroxy-acid dehydratase activity
BIS30_00570	COG1413	lyase activity
BIS30_00575	COG1418	mRNA catabolic process
BIS30_00580	COG0386	Belongs to the glutathione peroxidase family
BIS30_00585	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BIS30_00590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIS30_00595	COG1278	Cold shock
BIS30_00615	COG0328	RNA-DNA hybrid ribonuclease activity
BIS30_00620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BIS30_00625	COG0328	RNA-DNA hybrid ribonuclease activity
BIS30_00635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIS30_00655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BIS30_00660	COG1755	Isoprenylcysteine carboxyl methyltransferase
BIS30_00665	COG3424	synthase
BIS30_00670	COG2233	PERMEase
BIS30_00675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIS30_00680	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BIS30_00690	COG0800	Aldolase
BIS30_00700	COG1609	Transcriptional regulator
BIS30_00705	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BIS30_00710	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_00715	COG1199	ATP-dependent helicase activity
BIS30_00725	COG0116	Belongs to the methyltransferase superfamily
BIS30_00735	COG4474	Belongs to the UPF0398 family
BIS30_00750	COG3359	exonuclease
BIS30_00755	COG1111	helicase
BIS30_00755	COG1205	dead DEAH box helicase
BIS30_00760	COG2190	(PTS) system
BIS30_00765	COG0071	Belongs to the small heat shock protein (HSP20) family
BIS30_00800	COG3331	DNA recombination
BIS30_00805	COG4499	WXG100 protein secretion system (Wss), protein YukC
BIS30_00805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIS30_00815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BIS30_00820	COG3935	DnaD domain protein
BIS30_00825	COG0017	Asparaginyl-tRNA synthetase
BIS30_00830	COG0436	Aminotransferase
BIS30_00835	COG5353	protein conserved in bacteria
BIS30_00845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BIS30_00845	COG1199	ATP-dependent helicase activity
BIS30_00850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BIS30_00855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BIS30_00860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BIS30_00870	COG0617	tRNA 3'-terminal CCA addition
BIS30_00875	COG0438	transferase activity, transferring glycosyl groups
BIS30_00880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BIS30_00885	COG1803	Methylglyoxal synthase
BIS30_00890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BIS30_00895	COG1694	Mazg nucleotide pyrophosphohydrolase
BIS30_00900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_00910	COG4347	Protein of unknown function (DUF1405)
BIS30_00915	COG2010	Cytochrome c
BIS30_00915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BIS30_00920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BIS30_00925	COG0723	plastoquinol--plastocyanin reductase activity
BIS30_00935	COG5582	Belongs to the UPF0302 family
BIS30_00940	COG0457	Tetratricopeptide repeat
BIS30_00945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BIS30_00950	COG0287	Prephenate dehydrogenase
BIS30_00955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BIS30_00960	COG0159	tryptophan synthase activity
BIS30_00965	COG0133	tryptophan synthase activity
BIS30_00970	COG0135	phosphoribosylanthranilate isomerase activity
BIS30_00980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIS30_00985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BIS30_00990	COG4401	Chorismate mutase type I
BIS30_00995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BIS30_01000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BIS30_01005	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BIS30_01015	COG0105	UTP biosynthetic process
BIS30_01020	COG0142	geranyltranstransferase activity
BIS30_01025	COG2226	methyltransferase
BIS30_01030	COG0142	geranyltranstransferase activity
BIS30_01040	COG0302	gtp cyclohydrolase
BIS30_01045	COG0776	regulation of translation
BIS30_01050	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BIS30_01065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BIS30_01070	COG1160	GTP binding
BIS30_01095	COG1304	FMN binding
BIS30_01100	COG0539	negative regulation of cytoplasmic translation
BIS30_01105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BIS30_01115	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BIS30_01120	COG2959	enzyme of heme biosynthesis
BIS30_01125	COG3773	Cell wall hydrolase
BIS30_01125	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_01130	COG2339	peptidase activity
BIS30_01135	COG0492	ferredoxin-NADP+ reductase activity
BIS30_01140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIS30_01145	COG4862	establishment of competence for transformation
BIS30_01150	COG1408	metallophosphoesterase
BIS30_01160	COG1388	LysM domain
BIS30_01165	COG1266	CAAX protease self-immunity
BIS30_01170	COG0514	ATP-dependent DNA helicase (RecQ)
BIS30_01175	COG4955	Helix-turn-helix domain
BIS30_01180	COG1141	Ferredoxin
BIS30_01185	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BIS30_01195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BIS30_01200	COG0710	3-dehydroquinate dehydratase activity
BIS30_01210	COG1595	DNA-templated transcription, initiation
BIS30_01215	COG5002	protein histidine kinase activity
BIS30_01220	COG0745	RESPONSE REGULATOR receiver
BIS30_01225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BIS30_01235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_01240	COG1187	pseudouridine synthase activity
BIS30_01245	COG0700	Nucleoside recognition
BIS30_01250	COG2715	membrane protein required for spore maturation
BIS30_01255	COG1686	Belongs to the peptidase S11 family
BIS30_01265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BIS30_01270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BIS30_01275	COG1547	Domain of unknown function (DUF309)
BIS30_01280	COG0456	acetyltransferase
BIS30_01285	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BIS30_01290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIS30_01290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIS30_01295	COG0307	riboflavin synthase, alpha
BIS30_01300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIS30_01300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIS30_01310	COG0681	Belongs to the peptidase S26 family
BIS30_01315	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
BIS30_01325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BIS30_01335	COG4086	secreted protein
BIS30_01340	COG0019	diaminopimelate decarboxylase activity
BIS30_01345	COG0697	spore germination
BIS30_01360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIS30_01380	COG1191	sigma factor activity
BIS30_01385	COG2172	sigma factor antagonist activity
BIS30_01390	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_01395	COG1686	Belongs to the peptidase S11 family
BIS30_01400	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BIS30_01405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BIS30_01410	COG4974	Belongs to the 'phage' integrase family
BIS30_01420	COG0735	belongs to the Fur family
BIS30_01425	COG1300	Membrane
BIS30_01435	COG0281	malic enzyme
BIS30_01440	COG1757	Na H antiporter
BIS30_01445	COG1027	Aspartate ammonia-lyase
BIS30_01450	COG0252	asparaginase activity
BIS30_01455	COG1396	sequence-specific DNA binding
BIS30_01465	COG2801	Transposase and inactivated derivatives
BIS30_01475	COG0494	nUDIX hydrolase
BIS30_01495	COG1073	alpha beta
BIS30_01500	COG0772	Belongs to the SEDS family
BIS30_01505	COG0772	Belongs to the SEDS family
BIS30_01510	COG3339	Conserved Protein
BIS30_01520	COG4918	Iron-sulphur cluster biosynthesis
BIS30_01525	COG0456	acetyltransferase
BIS30_01525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BIS30_01530	COG2329	Antibiotic biosynthesis monooxygenase
BIS30_01535	COG0456	acetyltransferase
BIS30_01545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIS30_01560	COG2211	Major facilitator Superfamily
BIS30_01570	COG0346	lactoylglutathione lyase activity
BIS30_01575	COG1072	(Pantothenic acid kinase))
BIS30_01580	COG3048	D-serine ammonia-lyase activity
BIS30_01585	COG0300	oxidoreductase activity
BIS30_01590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_01595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIS30_01600	COG4187	Peptidase family M20/M25/M40
BIS30_01605	COG1902	pentaerythritol trinitrate reductase activity
BIS30_01610	COG0596	Alpha beta hydrolase
BIS30_01630	COG1234	tRNA 3'-trailer cleavage
BIS30_01635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BIS30_01640	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BIS30_01645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIS30_01655	COG0706	membrane insertase activity
BIS30_01660	COG3361	conserved protein (COG2071)
BIS30_01665	COG2195	Cleaves the N-terminal amino acid of tripeptides
BIS30_01675	COG0346	lactoylglutathione lyase activity
BIS30_01685	COG1376	ErfK ybiS ycfS ynhG family protein
BIS30_01690	COG4129	membrane
BIS30_01695	COG1126	abc transporter atp-binding protein
BIS30_01700	COG0765	amino acid transport
BIS30_01705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIS30_01715	COG1597	lipid kinase activity
BIS30_01720	COG2814	Major facilitator Superfamily
BIS30_01725	COG4978	Transcriptional regulator
BIS30_01725	COG0789	Transcriptional regulator
BIS30_01730	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIS30_01735	COG0022	dehydrogenase e1 component
BIS30_01740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BIS30_01745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIS30_01750	COG3426	butyrate kinase activity
BIS30_01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIS30_01760	COG0280	phosphate acetyltransferase
BIS30_01765	COG3829	transcription factor binding
BIS30_01765	COG3290	protein histidine kinase activity
BIS30_01775	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BIS30_01780	COG2079	MmgE PrpD family protein
BIS30_01785	COG0372	Belongs to the citrate synthase family
BIS30_01790	COG1960	acyl-CoA dehydrogenase activity
BIS30_01795	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIS30_01800	COG0183	Belongs to the thiolase family
BIS30_01805	COG0584	glycerophosphoryl diester phosphodiesterase
BIS30_01810	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_01825	COG1902	pentaerythritol trinitrate reductase activity
BIS30_01835	COG0745	RESPONSE REGULATOR receiver
BIS30_01845	COG0750	zinc metalloprotease
BIS30_01850	COG0497	DNA recombination
BIS30_01855	COG1438	arginine binding
BIS30_01860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BIS30_01865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIS30_01870	COG0142	geranyltranstransferase activity
BIS30_01875	COG1722	exodeoxyribonuclease VII activity
BIS30_01880	COG1570	exodeoxyribonuclease VII activity
BIS30_01890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIS30_01895	COG1302	Protein conserved in bacteria
BIS30_01905	COG0511	ligase activity, forming carbon-carbon bonds
BIS30_01945	COG3854	ATPases associated with a variety of cellular activities
BIS30_01955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BIS30_01960	COG0006	proline dipeptidase activity
BIS30_01965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BIS30_01975	COG3872	metal-dependent enzyme
BIS30_01985	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIS30_01990	COG1321	iron dependent repressor
BIS30_01995	COG0095	Lipoate-protein ligase
BIS30_02000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BIS30_02005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BIS30_02010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BIS30_02015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BIS30_02020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BIS30_02035	COG1396	sequence-specific DNA binding
BIS30_02045	COG0681	Belongs to the peptidase S26 family
BIS30_02070	COG4940	Competence protein ComGF
BIS30_02080	COG4970	Tfp pilus assembly protein FimT
BIS30_02085	COG4537	Required for transformation and DNA binding
BIS30_02090	COG1459	type II secretion system
BIS30_02095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BIS30_02100	COG0517	IMP dehydrogenase activity
BIS30_02105	COG0598	Magnesium transport protein CorA
BIS30_02115	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_02125	COG1393	Belongs to the ArsC family
BIS30_02135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_02145	COG0011	TIGRFAM Protein of
BIS30_02155	COG2866	Carboxypeptidase
BIS30_02160	COG1368	sulfuric ester hydrolase activity
BIS30_02165	COG1940	carbohydrate kinase activity
BIS30_02170	COG4483	Protein conserved in bacteria
BIS30_02175	COG0705	Rhomboid family
BIS30_02175	COG0457	Tetratricopeptide repeat
BIS30_02185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BIS30_02190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BIS30_02195	COG0438	transferase activity, transferring glycosyl groups
BIS30_02210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BIS30_02215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BIS30_02220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BIS30_02225	COG0581	inorganic phosphate transmembrane transporter activity
BIS30_02230	COG0573	inorganic phosphate transmembrane transporter activity
BIS30_02235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BIS30_02245	COG0477	Major facilitator Superfamily
BIS30_02250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BIS30_02255	COG2839	Protein conserved in bacteria
BIS30_02260	COG5521	maltodextrose utilization protein MalA
BIS30_02265	COG1388	LysM domain
BIS30_02275	COG4709	membrane
BIS30_02280	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BIS30_02285	COG0735	belongs to the Fur family
BIS30_02290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_02300	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BIS30_02305	COG0513	Belongs to the DEAD box helicase family
BIS30_02315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BIS30_02320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BIS30_02325	COG2384	SAM-dependent methyltransferase
BIS30_02330	COG2010	Cytochrome c
BIS30_02335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIS30_02340	COG0358	DNA primase activity
BIS30_02345	COG1671	Belongs to the UPF0178 family
BIS30_02350	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BIS30_02355	COG0517	IMP dehydrogenase activity
BIS30_02360	COG0751	glycine-tRNA ligase activity
BIS30_02365	COG0752	glycyl-tRNA synthetase alpha subunit
BIS30_02370	COG1381	Involved in DNA repair and RecF pathway recombination
BIS30_02380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BIS30_02385	COG0295	cytidine deaminase activity
BIS30_02390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BIS30_02395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BIS30_02400	COG1480	7TM receptor with intracellular HD hydrolase
BIS30_02410	COG1702	phosphate starvation-inducible protein PhoH
BIS30_02415	COG0561	phosphatase activity
BIS30_02430	COG4864	UPF0365 protein
BIS30_02435	COG1030	water channel activity
BIS30_02440	COG1610	YqeY-like protein
BIS30_02445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BIS30_02450	COG1283	sodium-dependent phosphate transmembrane transporter activity
BIS30_02455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BIS30_02460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BIS30_02465	COG2264	protein methyltransferase activity
BIS30_02470	COG0484	heat shock protein binding
BIS30_02480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BIS30_02485	COG1420	regulation of RNA biosynthetic process
BIS30_02490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BIS30_02495	COG0481	GTPase activity
BIS30_02505	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_02510	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BIS30_02515	COG0268	Binds directly to 16S ribosomal RNA
BIS30_02520	COG1466	dna polymerase III delta subunit
BIS30_02530	COG2333	competence protein COMEC
BIS30_02530	COG0658	competence protein
BIS30_02535	COG2131	deaminase
BIS30_02540	COG1596	polysaccharide export
BIS30_02540	COG1555	photosystem II stabilization
BIS30_02545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIS30_02550	COG2226	methyltransferase
BIS30_02555	COG0799	negative regulation of ribosome biogenesis
BIS30_02560	COG1713	HD superfamily hydrolase involved in NAD metabolism
BIS30_02565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BIS30_02570	COG1534	Rna-binding protein
BIS30_02575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIS30_02580	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BIS30_02585	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BIS30_02600	COG2755	lipolytic protein G-D-S-L family
BIS30_02610	COG5632	N-Acetylmuramoyl-L-alanine amidase
BIS30_02610	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_02615	COG0398	Pfam SNARE associated Golgi protein
BIS30_02620	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BIS30_02630	COG3209	COG3209 Rhs family protein
BIS30_02640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BIS30_02645	COG0114	fumarate hydratase activity
BIS30_02650	COG0583	DNA-binding transcription factor activity
BIS30_02670	COG2070	2-Nitropropane dioxygenase
BIS30_02675	COG1846	Transcriptional regulator
BIS30_02685	COG1733	regulation of RNA biosynthetic process
BIS30_02695	COG2207	Transcriptional regulator
BIS30_02705	COG4221	oxidoreductase activity
BIS30_02710	COG0456	acetyltransferase
BIS30_02715	COG4978	Transcriptional regulator
BIS30_02715	COG0789	Transcriptional regulator
BIS30_02720	COG2814	Major facilitator Superfamily
BIS30_02725	COG1183	phosphatidylcholine synthase activity
BIS30_02735	COG2186	Transcriptional regulator
BIS30_02740	COG0205	6-phosphofructokinase activity
BIS30_02750	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_02755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIS30_02760	COG3959	Transketolase, thiamine diphosphate binding domain
BIS30_02775	COG0640	Transcriptional regulator
BIS30_02780	COG1115	amino acid carrier protein
BIS30_02785	COG2315	Protein conserved in bacteria
BIS30_02800	COG3443	Belongs to the bacterial solute-binding protein 9 family
BIS30_02805	COG4991	sh3 domain protein
BIS30_02810	COG4991	sh3 domain protein
BIS30_02820	COG5577	PFAM Coat F domain
BIS30_02825	COG1063	alcohol dehydrogenase
BIS30_02835	COG5577	PFAM Coat F domain
BIS30_02845	COG0667	Aldo Keto reductase
BIS30_02850	COG2207	Transcriptional regulator
BIS30_02855	COG0789	Transcriptional regulator
BIS30_02860	COG0789	Transcriptional regulator
BIS30_02865	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BIS30_02870	COG1064	alcohol dehydrogenase
BIS30_02875	COG0693	protein deglycase activity
BIS30_02880	COG1621	beta-fructofuranosidase activity
BIS30_02885	COG3716	PTS system mannose fructose sorbose family IID component
BIS30_02890	COG3715	PTS system
BIS30_02895	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_02900	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_02905	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BIS30_02905	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BIS30_02920	COG1113	amino acid transport
BIS30_02925	COG1280	lysine exporter protein (LysE YggA)
BIS30_02930	COG1378	Sugar-specific transcriptional regulator TrmB
BIS30_02935	COG1595	DNA-templated transcription, initiation
BIS30_02945	COG2755	lipolytic protein G-D-S-L family
BIS30_02945	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BIS30_02955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BIS30_02955	COG2124	cytochrome p450
BIS30_02960	COG1309	transcriptional regulator
BIS30_02965	COG2226	methyltransferase
BIS30_02985	COG2116	formate transmembrane transporter activity
BIS30_02990	COG5609	conserved protein (DUF2294)
BIS30_02995	COG3383	formate dehydrogenase (NAD+) activity
BIS30_03000	COG2427	Protein of unknown function (DUF1641)
BIS30_03010	COG0626	cystathionine gamma-synthase activity
BIS30_03015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BIS30_03020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BIS30_03025	COG2226	methyltransferase
BIS30_03040	COG0768	penicillin binding
BIS30_03045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BIS30_03050	COG0572	uridine kinase
BIS30_03070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BIS30_03075	COG3906	Belongs to the UPF0473 family
BIS30_03080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BIS30_03085	COG4472	Bacterial protein of unknown function (DUF965)
BIS30_03090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BIS30_03095	COG0628	permease
BIS30_03110	COG3881	PFAM PRC-barrel domain
BIS30_03115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BIS30_03120	COG0457	Tetratricopeptide repeat
BIS30_03125	COG0482	sulfurtransferase activity
BIS30_03130	COG1104	cysteine desulfurase activity
BIS30_03135	COG1959	2 iron, 2 sulfur cluster binding
BIS30_03140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BIS30_03155	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BIS30_03165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BIS30_03170	COG0124	histidyl-tRNA synthetase
BIS30_03185	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_03185	COG3103	Sh3 type 3 domain protein
BIS30_03185	COG4991	sh3 domain protein
BIS30_03190	COG1490	D-aminoacyl-tRNA deacylase activity
BIS30_03195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIS30_03200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIS30_03205	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BIS30_03205	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BIS30_03210	COG5416	Lipopolysaccharide assembly protein A domain
BIS30_03215	COG0490	domain, Protein
BIS30_03220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIS30_03220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIS30_03230	COG2244	polysaccharide biosynthetic process
BIS30_03235	COG2323	membrane
BIS30_03245	COG1862	Preprotein translocase
BIS30_03250	COG0343	queuine tRNA-ribosyltransferase activity
BIS30_03255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BIS30_03265	COG2255	four-way junction helicase activity
BIS30_03270	COG0632	four-way junction helicase activity
BIS30_03280	COG2814	Major facilitator Superfamily
BIS30_03285	COG0673	inositol 2-dehydrogenase activity
BIS30_03290	COG2112	serine threonine protein kinase
BIS30_03300	COG1115	amino acid carrier protein
BIS30_03305	COG0217	transcriptional regulatory protein
BIS30_03315	COG1388	LysM domain
BIS30_03335	COG1104	cysteine desulfurase activity
BIS30_03340	COG1827	regulation of RNA biosynthetic process
BIS30_03345	COG0077	Prephenate dehydratase
BIS30_03350	COG4492	Belongs to the UPF0735 family
BIS30_03355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BIS30_03360	COG3290	protein histidine kinase activity
BIS30_03370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BIS30_03375	COG2868	ribosomal protein
BIS30_03380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BIS30_03385	COG1994	Peptidase M50
BIS30_03390	COG0739	heme binding
BIS30_03395	COG2894	cell division
BIS30_03400	COG0850	regulation of cytokinetic process
BIS30_03405	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BIS30_03410	COG1792	Involved in formation and maintenance of cell shape
BIS30_03415	COG1077	Cell shape determining protein MreB Mrl
BIS30_03420	COG2003	Belongs to the UPF0758 family
BIS30_03425	COG0424	maF-like protein
BIS30_03435	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BIS30_03440	COG0285	dihydrofolate synthase activity
BIS30_03445	COG0525	valine-tRNA ligase activity
BIS30_03455	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIS30_03460	COG1388	LysM domain
BIS30_03465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BIS30_03470	COG0113	porphobilinogen synthase activity
BIS30_03475	COG1587	Uroporphyrinogen-III synthase
BIS30_03480	COG0181	hydroxymethylbilane synthase activity
BIS30_03485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BIS30_03490	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BIS30_03500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BIS30_03505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BIS30_03510	COG0470	DNA polymerase III
BIS30_03510	COG1067	ATP-dependent peptidase activity
BIS30_03520	COG0544	peptidyl-prolyl cis-trans isomerase activity
BIS30_03525	COG1477	protein flavinylation
BIS30_03525	COG0457	Tetratricopeptide repeat
BIS30_03530	COG0066	3-isopropylmalate dehydratase activity
BIS30_03535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BIS30_03540	COG0473	3-isopropylmalate dehydrogenase activity
BIS30_03550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BIS30_03555	COG0440	acetolactate synthase activity
BIS30_03560	COG0028	Belongs to the TPP enzyme family
BIS30_03570	COG0454	-acetyltransferase
BIS30_03580	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BIS30_03590	COG0622	Phosphoesterase
BIS30_03595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BIS30_03600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BIS30_03605	COG5401	PFAM Sporulation and spore germination
BIS30_03610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BIS30_03615	COG1846	Transcriptional regulator
BIS30_03620	COG2197	response regulator
BIS30_03625	COG0824	Thioesterase
BIS30_03630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BIS30_03635	COG1053	succinate dehydrogenase
BIS30_03640	COG2009	succinate dehydrogenase
BIS30_03650	COG1719	4-vinyl reductase, 4VR
BIS30_03655	COG0527	aspartate kinase activity
BIS30_03660	COG0322	excinuclease ABC activity
BIS30_03665	COG3118	belongs to the thioredoxin family
BIS30_03670	COG3534	alpha-L-arabinofuranosidase
BIS30_03675	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BIS30_03680	COG2086	electron transfer activity
BIS30_03685	COG1024	Enoyl-CoA hydratase
BIS30_03690	COG1309	transcriptional regulator
BIS30_03695	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_03700	COG3766	membrane
BIS30_03705	COG1193	negative regulation of DNA recombination
BIS30_03715	COG1286	toxin biosynthetic process
BIS30_03720	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BIS30_03725	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BIS30_03730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIS30_03730	COG0072	phenylalanine-tRNA ligase activity
BIS30_03735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BIS30_03740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIS30_03750	COG0584	glycerophosphoryl diester phosphodiesterase
BIS30_03755	COG0277	FAD linked oxidase domain protein
BIS30_03760	COG0247	lactate metabolic process
BIS30_03765	COG0346	lactoylglutathione lyase activity
BIS30_03770	COG1966	Carbon starvation protein
BIS30_03785	COG1695	Transcriptional regulator
BIS30_03790	COG3534	alpha-L-arabinofuranosidase
BIS30_03795	COG0395	ABC-type sugar transport system, permease component
BIS30_03805	COG1653	transport
BIS30_03810	COG0371	Dehydrogenase
BIS30_03815	COG0647	UMP catabolic process
BIS30_03820	COG0235	Class ii aldolase
BIS30_03825	COG1069	ribulokinase activity
BIS30_03830	COG2160	L-arabinose isomerase activity
BIS30_03835	COG3507	Belongs to the glycosyl hydrolase 43 family
BIS30_03840	COG1363	Peptidase, m42
BIS30_03850	COG3326	Membrane
BIS30_03855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BIS30_03860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BIS30_03865	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BIS30_03880	COG1346	cytolysis
BIS30_03885	COG1380	Effector of murein hydrolase LrgA
BIS30_03905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BIS30_03915	COG0398	Pfam SNARE associated Golgi protein
BIS30_03920	COG1484	DNA-dependent DNA replication
BIS30_03925	COG3611	Membrane attachment protein
BIS30_03930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BIS30_03935	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BIS30_03940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BIS30_03945	COG1733	regulation of RNA biosynthetic process
BIS30_03950	COG2814	Major facilitator Superfamily
BIS30_03955	COG0656	L-ascorbic acid biosynthetic process
BIS30_03960	COG0237	dephospho-CoA kinase activity
BIS30_03975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BIS30_03980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIS30_03980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BIS30_03985	COG5002	protein histidine kinase activity
BIS30_03990	COG0745	RESPONSE REGULATOR receiver
BIS30_03995	COG0039	L-malate dehydrogenase activity
BIS30_04000	COG0538	isocitrate dehydrogenase activity
BIS30_04005	COG0372	Belongs to the citrate synthase family
BIS30_04010	COG2707	UPF0756 membrane protein
BIS30_04015	COG0628	permease
BIS30_04020	COG3030	protein affecting phage T7 exclusion by the F plasmid
BIS30_04025	COG0469	pyruvate kinase activity
BIS30_04030	COG0205	6-phosphofructokinase activity
BIS30_04035	COG0825	malonyl-CoA metabolic process
BIS30_04040	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BIS30_04045	COG0281	malic enzyme
BIS30_04050	COG0587	DNA-directed DNA polymerase activity
BIS30_04070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BIS30_04080	COG4109	DRTGG domain
BIS30_04085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BIS30_04090	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_04100	COG0165	Argininosuccinate lyase
BIS30_04105	COG0137	argininosuccinate synthase activity
BIS30_04110	COG0521	Mo-molybdopterin cofactor biosynthetic process
BIS30_04115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BIS30_04120	COG0827	DNA restriction-modification system
BIS30_04125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BIS30_04130	COG3874	Sporulation protein YtfJ
BIS30_04140	COG1714	RDD family
BIS30_04145	COG0616	signal peptide processing
BIS30_04150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BIS30_04155	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BIS30_04160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIS30_04170	COG0301	tRNA thio-modification
BIS30_04175	COG1104	cysteine desulfurase activity
BIS30_04180	COG1114	Component of the transport system for branched-chain amino acids
BIS30_04185	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BIS30_04190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BIS30_04195	COG1309	transcriptional regulator
BIS30_04200	COG1956	GAF domain-containing protein
BIS30_04205	COG2203	Gaf domain
BIS30_04205	COG2199	diguanylate cyclase activity
BIS30_04210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BIS30_04220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BIS30_04225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIS30_04230	COG0454	-acetyltransferase
BIS30_04235	COG0517	IMP dehydrogenase activity
BIS30_04240	COG0123	including yeast histone deacetylase and acetoin utilization protein
BIS30_04245	COG1360	Flagellar Motor Protein
BIS30_04250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BIS30_04255	COG1609	Transcriptional regulator
BIS30_04260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BIS30_04260	COG1605	Chorismate mutase
BIS30_04265	COG3118	belongs to the thioredoxin family
BIS30_04270	COG4980	gas vesicle protein
BIS30_04275	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BIS30_04280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BIS30_04285	COG1674	ftsk spoiiie
BIS30_04290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIS30_04295	COG4848	Belongs to the UPF0354 family
BIS30_04300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_04310	COG1363	Peptidase, m42
BIS30_04315	COG5584	Small secreted protein
BIS30_04320	COG0281	malic enzyme
BIS30_04325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_04330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BIS30_04340	COG0510	thiamine kinase activity
BIS30_04345	COG1523	belongs to the glycosyl hydrolase 13 family
BIS30_04350	COG1597	lipid kinase activity
BIS30_04360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BIS30_04365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BIS30_04370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIS30_04375	COG2252	PERMEase
BIS30_04380	COG4473	ABC transporter
BIS30_04385	COG1131	(ABC) transporter
BIS30_04390	COG1349	DNA-binding transcription factor activity
BIS30_04395	COG1187	pseudouridine synthase activity
BIS30_04400	COG2244	polysaccharide biosynthetic process
BIS30_04405	COG2081	HI0933 family
BIS30_04410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BIS30_04420	COG5578	integral membrane protein
BIS30_04425	COG0673	inositol 2-dehydrogenase activity
BIS30_04430	COG1653	transport
BIS30_04435	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BIS30_04440	COG4209	transmembrane transport
BIS30_04445	COG2207	Transcriptional regulator
BIS30_04450	COG1653	transport
BIS30_04455	COG0395	ABC-type sugar transport system, permease component
BIS30_04460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BIS30_04465	COG2124	cytochrome p450
BIS30_04470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BIS30_04480	COG0156	8-amino-7-oxononanoate synthase activity
BIS30_04485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BIS30_04500	COG1073	alpha beta
BIS30_04525	COG1486	melibiose metabolic process
BIS30_04530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BIS30_04535	COG0495	leucyl-tRNA aminoacylation
BIS30_04545	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_04545	COG2202	Pas domain
BIS30_04550	COG2814	Major facilitator Superfamily
BIS30_04555	COG2433	Pfam Transposase IS66
BIS30_04560	COG0577	efflux transmembrane transporter activity
BIS30_04565	COG1136	(ABC) transporter
BIS30_04570	COG2205	protein histidine kinase activity
BIS30_04575	COG0745	RESPONSE REGULATOR receiver
BIS30_04585	COG1136	(ABC) transporter
BIS30_04600	COG1131	(ABC) transporter
BIS30_04605	COG1725	Transcriptional regulator
BIS30_04620	COG1242	4 iron, 4 sulfur cluster binding
BIS30_04625	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BIS30_04635	COG2267	carboxylic ester hydrolase activity
BIS30_04640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BIS30_04645	COG1113	amino acid transport
BIS30_04655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BIS30_04660	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BIS30_04670	COG1506	peptidase
BIS30_04675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIS30_04680	COG1116	anion transmembrane transporter activity
BIS30_04685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIS30_04690	COG2801	Transposase and inactivated derivatives
BIS30_04700	COG0494	nUDIX hydrolase
BIS30_04705	COG4824	toxin secretion phage lysis holin
BIS30_04710	COG0783	Belongs to the Dps family
BIS30_04725	COG1854	S-ribosylhomocysteine lyase activity
BIS30_04730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BIS30_04735	COG0288	reversible hydration of carbon dioxide
BIS30_04740	COG0254	rRNA binding
BIS30_04745	COG1271	oxidase subunit
BIS30_04750	COG1294	oxidase, subunit
BIS30_04760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BIS30_04765	COG1321	iron dependent repressor
BIS30_04765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BIS30_04770	COG1121	(ABC) transporter
BIS30_04775	COG0803	Belongs to the bacterial solute-binding protein 9 family
BIS30_04780	COG4948	Mandelate Racemase Muconate Lactonizing
BIS30_04785	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_04790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BIS30_04795	COG0596	Alpha beta hydrolase
BIS30_04800	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BIS30_04805	COG1169	isochorismate synthase
BIS30_04810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BIS30_04815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIS30_04820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BIS30_04825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BIS30_04830	COG0438	transferase activity, transferring glycosyl groups
BIS30_04840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIS30_04845	COG0438	transferase activity, transferring glycosyl groups
BIS30_04850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIS30_04855	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BIS30_04860	COG0058	SHG alpha-glucan phosphorylase activity
BIS30_04865	COG0297	glycogen (starch) synthase activity
BIS30_04870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BIS30_04875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BIS30_04880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BIS30_05010	COG3859	Proton-coupled thiamine transporter YuaJ
BIS30_05015	COG1247	-acetyltransferase
BIS30_05020	COG2268	Band 7 protein
BIS30_05025	COG1585	Membrane protein implicated in regulation of membrane protease activity
BIS30_05030	COG2318	DinB family
BIS30_05040	COG1454	alcohol dehydrogenase
BIS30_05050	COG1510	regulation of RNA biosynthetic process
BIS30_05060	COG0569	domain protein
BIS30_05065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BIS30_05070	COG4682	membrane
BIS30_05075	COG1705	Flagellar rod assembly protein muramidase FlgJ
BIS30_05080	COG0477	Major facilitator Superfamily
BIS30_05085	COG5553	Cysteine dioxygenase type I
BIS30_05095	COG1968	undecaprenyl-diphosphatase activity
BIS30_05100	COG0628	permease
BIS30_05105	COG0673	inositol 2-dehydrogenase activity
BIS30_05110	COG4806	L-rhamnose isomerase
BIS30_05115	COG3254	rhamnose metabolic process
BIS30_05120	COG1070	Carbohydrate kinase
BIS30_05125	COG1349	DNA-binding transcription factor activity
BIS30_05130	COG3347	Dehydrogenase
BIS30_05130	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_05135	COG0840	transmembrane signaling receptor activity
BIS30_05140	COG0840	transmembrane signaling receptor activity
BIS30_05145	COG0840	transmembrane signaling receptor activity
BIS30_05150	COG0840	transmembrane signaling receptor activity
BIS30_05165	COG2070	2-Nitropropane dioxygenase
BIS30_05170	COG0432	Pfam Uncharacterised protein family UPF0047
BIS30_05175	COG0366	Alpha amylase catalytic
BIS30_05185	COG2801	Transposase and inactivated derivatives
BIS30_05190	COG1253	flavin adenine dinucleotide binding
BIS30_05195	COG2738	Putative neutral zinc metallopeptidase
BIS30_05210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BIS30_05225	COG0166	Belongs to the GPI family
BIS30_05230	COG1979	alcohol dehydrogenase
BIS30_05235	COG1979	alcohol dehydrogenase
BIS30_05240	COG2155	Conserved Protein
BIS30_05245	COG1098	S1 RNA binding domain
BIS30_05250	COG0436	Aminotransferase
BIS30_05255	COG1522	sequence-specific DNA binding
BIS30_05260	COG2267	carboxylic ester hydrolase activity
BIS30_05270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BIS30_05275	COG2205	protein histidine kinase activity
BIS30_05285	COG5018	Exonuclease
BIS30_05295	COG2814	Major facilitator Superfamily
BIS30_05300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIS30_05305	COG3011	Protein conserved in bacteria
BIS30_05315	COG3290	protein histidine kinase activity
BIS30_05320	COG4565	transcriptional regulatory protein
BIS30_05325	COG3493	citrate carrier protein
BIS30_05335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BIS30_05335	COG2111	Na H antiporter
BIS30_05340	COG2111	Na H antiporter
BIS30_05345	COG1006	Multisubunit Na H antiporter MnhC subunit
BIS30_05350	COG0651	ATP synthesis coupled electron transport
BIS30_05360	COG2212	antiporter activity
BIS30_05365	COG1320	monovalent cation:proton antiporter activity
BIS30_05370	COG2050	protein possibly involved in aromatic compounds catabolism
BIS30_05375	COG2197	response regulator
BIS30_05380	COG4585	Histidine kinase
BIS30_05390	COG0142	geranyltranstransferase activity
BIS30_05405	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BIS30_05410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BIS30_05415	COG1335	isochorismatase
BIS30_05420	COG5506	Protein of unknown function (DUF1694)
BIS30_05435	COG0628	permease
BIS30_05450	COG1418	mRNA catabolic process
BIS30_05455	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_05465	COG1511	domain protein
BIS30_05470	COG0433	COG0433 Predicted ATPase
BIS30_05470	COG1674	ftsk spoiiie
BIS30_05475	COG4499	WXG100 protein secretion system (Wss), protein YukC
BIS30_05480	COG5417	Belongs to the EsaB family
BIS30_05485	COG4842	Belongs to the WXG100 family
BIS30_05490	COG2508	Transcriptional regulator
BIS30_05490	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BIS30_05495	COG0686	Belongs to the AlaDH PNT family
BIS30_05500	COG5634	Uncharacterized conserved protein (DUF2278)
BIS30_05505	COG3251	PFAM MbtH domain protein
BIS30_05510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_05515	COG1535	isochorismatase
BIS30_05515	COG3433	isochorismatase activity
BIS30_05520	COG1021	2,3-dihydroxybenzoate-AMP ligase
BIS30_05525	COG1169	isochorismate synthase
BIS30_05530	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_05535	COG2819	hydrolase of the alpha beta superfamily
BIS30_05540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BIS30_05545	COG1268	BioY protein
BIS30_05550	COG2056	Na+-H+ antiporter family
BIS30_05555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BIS30_05560	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BIS30_05565	COG3584	3D domain protein
BIS30_05580	COG1252	NADH dehydrogenase
BIS30_05585	COG0492	ferredoxin-NADP+ reductase activity
BIS30_05595	COG0516	GMP reductase activity
BIS30_05610	COG1131	(ABC) transporter
BIS30_05630	COG0456	acetyltransferase
BIS30_05640	COG0316	Belongs to the HesB IscA family
BIS30_05645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BIS30_05650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BIS30_05655	COG4844	belongs to the
BIS30_05660	COG1252	NADH dehydrogenase
BIS30_05665	COG4837	Protein of unknown function (DUF1462)
BIS30_05670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BIS30_05675	COG0823	Involved in the tonB-independent uptake of proteins
BIS30_05675	COG1506	peptidase
BIS30_05675	COG4946	Tricorn protease homolog
BIS30_05680	COG0083	homoserine kinase activity
BIS30_05685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BIS30_05690	COG0460	homoserine dehydrogenase
BIS30_05695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIS30_05700	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BIS30_05705	COG0647	UMP catabolic process
BIS30_05710	COG2445	Protein of unknown function DUF86
BIS30_05715	COG4470	Protein conserved in bacteria
BIS30_05725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BIS30_05730	COG0739	heme binding
BIS30_05740	COG3377	Domain of unknown function (DUF1805)
BIS30_05745	COG0737	Belongs to the 5'-nucleotidase family
BIS30_05750	COG0730	response to heat
BIS30_05755	COG1801	Protein of unknown function DUF72
BIS30_05765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BIS30_05770	COG2508	Transcriptional regulator
BIS30_05775	COG2233	PERMEase
BIS30_05780	COG2233	PERMEase
BIS30_05785	COG3648	Uricase
BIS30_05785	COG3195	allantoin biosynthetic process
BIS30_05790	COG2351	hydroxyisourate hydrolase activity
BIS30_05805	COG2080	2 iron, 2 sulfur cluster binding
BIS30_05810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BIS30_05815	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BIS30_05820	COG2068	MobA-Related Protein
BIS30_05825	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BIS30_05830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BIS30_05835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIS30_05850	COG2356	endonuclease I
BIS30_05855	COG3842	ATPase activity
BIS30_05865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIS30_05870	COG0395	ABC-type sugar transport system, permease component
BIS30_05875	COG1175	transmembrane transport
BIS30_05880	COG1653	transport
BIS30_05885	COG2222	sugar isomerase
BIS30_05890	COG0322	excinuclease ABC activity
BIS30_05895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIS30_05910	COG0346	lactoylglutathione lyase activity
BIS30_05915	COG0640	Transcriptional regulator
BIS30_05920	COG0719	Fe-S assembly protein
BIS30_05925	COG0822	iron-sulfur transferase activity
BIS30_05930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BIS30_05935	COG0719	Fe-S assembly protein
BIS30_05940	COG0396	ATPase activity
BIS30_05955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BIS30_05960	COG1464	Belongs to the NlpA lipoprotein family
BIS30_05965	COG2011	ABC-type metal ion transport system permease component
BIS30_05970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BIS30_05980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_05985	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BIS30_05995	COG0509	glycine decarboxylation via glycine cleavage system
BIS30_06000	COG1393	Belongs to the ArsC family
BIS30_06005	COG1960	acyl-CoA dehydrogenase activity
BIS30_06010	COG0183	Belongs to the thiolase family
BIS30_06025	COG0506	proline dehydrogenase activity
BIS30_06035	COG5577	PFAM Coat F domain
BIS30_06040	COG1846	Transcriptional regulator
BIS30_06045	COG0477	Major facilitator Superfamily
BIS30_06050	COG1942	4-Oxalocrotonate Tautomerase
BIS30_06055	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_06060	COG0583	DNA-binding transcription factor activity
BIS30_06070	COG1120	ATPase activity
BIS30_06085	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_06090	COG0783	Belongs to the Dps family
BIS30_06095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIS30_06100	COG0745	RESPONSE REGULATOR receiver
BIS30_06105	COG2770	Histidine kinase
BIS30_06105	COG2205	protein histidine kinase activity
BIS30_06115	COG1309	transcriptional regulator
BIS30_06120	COG0114	fumarate hydratase activity
BIS30_06130	COG0697	spore germination
BIS30_06145	COG2197	response regulator
BIS30_06150	COG4585	Histidine kinase
BIS30_06155	COG4758	membrane
BIS30_06160	COG3595	metallopeptidase activity
BIS30_06165	COG1842	Phage shock protein A
BIS30_06170	COG4758	membrane
BIS30_06175	COG2814	Major facilitator Superfamily
BIS30_06180	COG2096	Adenosyltransferase
BIS30_06185	COG1120	ATPase activity
BIS30_06190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_06195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_06205	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_06210	COG3386	PFAM SMP-30 Gluconolaconase
BIS30_06215	COG2205	protein histidine kinase activity
BIS30_06220	COG0745	RESPONSE REGULATOR receiver
BIS30_06230	COG1191	sigma factor activity
BIS30_06240	COG2140	Oxalate decarboxylase
BIS30_06250	COG0577	efflux transmembrane transporter activity
BIS30_06260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIS30_06265	COG1120	ATPase activity
BIS30_06270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_06275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_06280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_06290	COG0531	amino acid
BIS30_06300	COG1988	membrane-bound metal-dependent
BIS30_06305	COG1368	sulfuric ester hydrolase activity
BIS30_06310	COG1910	domain protein
BIS30_06315	COG0725	ABC transporter, periplasmic molybdate-binding protein
BIS30_06320	COG4149	molybdate abc transporter
BIS30_06325	COG0656	L-ascorbic acid biosynthetic process
BIS30_06335	COG0025	NhaP-type Na H and K H
BIS30_06340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BIS30_06345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BIS30_06350	COG3973	AAA domain
BIS30_06355	COG2860	membrane
BIS30_06360	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BIS30_06365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BIS30_06370	COG2217	Heavy metal translocating P-type atpase
BIS30_06375	COG2217	Heavy metal translocating P-type atpase
BIS30_06380	COG2608	mercury ion transmembrane transporter activity
BIS30_06385	COG1937	Protein conserved in bacteria
BIS30_06390	COG0673	inositol 2-dehydrogenase activity
BIS30_06395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BIS30_06400	COG1289	transmembrane transporter activity
BIS30_06405	COG1802	Transcriptional regulator
BIS30_06410	COG0697	spore germination
BIS30_06415	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_06440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BIS30_06445	COG0557	exoribonuclease II activity
BIS30_06450	COG1647	Serine aminopeptidase, S33
BIS30_06455	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIS30_06460	COG0596	Alpha beta hydrolase
BIS30_06465	COG1476	TRANSCRIPTIONal
BIS30_06470	COG1396	sequence-specific DNA binding
BIS30_06475	COG1396	sequence-specific DNA binding
BIS30_06480	COG1733	regulation of RNA biosynthetic process
BIS30_06535	COG1174	glycine betaine transport
BIS30_06540	COG1732	Glycine betaine
BIS30_06545	COG1174	glycine betaine transport
BIS30_06550	COG0517	IMP dehydrogenase activity
BIS30_06550	COG1125	glycine betaine transport
BIS30_06555	COG1510	regulation of RNA biosynthetic process
BIS30_06560	COG2801	Transposase and inactivated derivatives
BIS30_06570	COG1174	glycine betaine transport
BIS30_06575	COG1732	Glycine betaine
BIS30_06580	COG1174	glycine betaine transport
BIS30_06585	COG1125	glycine betaine transport
BIS30_06585	COG0517	IMP dehydrogenase activity
BIS30_06590	COG1510	regulation of RNA biosynthetic process
BIS30_06600	COG3064	Membrane
BIS30_06605	COG4640	response to antibiotic
BIS30_06610	COG0456	acetyltransferase
BIS30_06620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BIS30_06625	COG0149	triose-phosphate isomerase activity
BIS30_06630	COG0126	phosphoglycerate kinase activity
BIS30_06640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BIS30_06645	COG2390	Transcriptional regulator
BIS30_06650	COG2814	Major facilitator Superfamily
BIS30_06655	COG1609	Transcriptional regulator
BIS30_06660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIS30_06665	COG0697	spore germination
BIS30_06670	COG1113	amino acid transport
BIS30_06675	COG3858	chitin binding
BIS30_06680	COG1556	Lactate utilization protein
BIS30_06685	COG1139	Iron-sulfur cluster binding protein
BIS30_06705	COG2197	response regulator
BIS30_06710	COG4585	Histidine kinase
BIS30_06715	COG0842	Transport permease protein
BIS30_06720	COG1131	(ABC) transporter
BIS30_06725	COG0596	Alpha beta hydrolase
BIS30_06730	COG2208	phosphoserine phosphatase activity
BIS30_06740	COG1874	Beta-galactosidase
BIS30_06745	COG3833	ABC-type maltose transport systems, permease component
BIS30_06750	COG1175	transmembrane transport
BIS30_06755	COG2182	Extracellular solute-binding protein
BIS30_06760	COG1609	Transcriptional regulator
BIS30_06765	COG2186	Transcriptional regulator
BIS30_06770	COG1620	l-lactate permease
BIS30_06775	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BIS30_06785	COG5039	Polysaccharide pyruvyl transferase
BIS30_06790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BIS30_06795	COG0110	maltose O-acetyltransferase activity
BIS30_06800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BIS30_06805	COG2244	polysaccharide biosynthetic process
BIS30_06810	COG1216	Glycosyl transferase, family 2
BIS30_06815	COG5039	Polysaccharide pyruvyl transferase
BIS30_06820	COG1216	Glycosyl transferase, family 2
BIS30_06830	COG0438	transferase activity, transferring glycosyl groups
BIS30_06835	COG1215	transferase activity, transferring glycosyl groups
BIS30_06840	COG0438	transferase activity, transferring glycosyl groups
BIS30_06845	COG1086	Polysaccharide biosynthesis protein
BIS30_06850	COG0489	protein tyrosine kinase activity
BIS30_06855	COG3944	biosynthesis protein
BIS30_06860	COG1396	sequence-specific DNA binding
BIS30_06865	COG2272	Belongs to the type-B carboxylesterase lipase family
BIS30_06875	COG3479	Phenolic acid decarboxylase
BIS30_06885	COG1794	racemase activity, acting on amino acids and derivatives
BIS30_06890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIS30_06895	COG1621	beta-fructofuranosidase activity
BIS30_06900	COG1621	beta-fructofuranosidase activity
BIS30_06905	COG0531	amino acid
BIS30_06910	COG1309	transcriptional regulator
BIS30_06915	COG2076	Multidrug Resistance protein
BIS30_06920	COG2076	Multidrug Resistance protein
BIS30_06940	COG1611	Belongs to the LOG family
BIS30_06945	COG1694	Mazg nucleotide pyrophosphohydrolase
BIS30_06950	COG0659	secondary active sulfate transmembrane transporter activity
BIS30_06955	COG0288	reversible hydration of carbon dioxide
BIS30_06960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIS30_06965	COG0577	efflux transmembrane transporter activity
BIS30_06970	COG1136	(ABC) transporter
BIS30_06975	COG5002	protein histidine kinase activity
BIS30_06980	COG0745	RESPONSE REGULATOR receiver
BIS30_06990	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BIS30_06995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_07000	COG1481	regulation of sporulation
BIS30_07005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BIS30_07010	COG1660	Displays ATPase and GTPase activities
BIS30_07015	COG1051	belongs to the nudix hydrolase family
BIS30_07020	COG0492	ferredoxin-NADP+ reductase activity
BIS30_07025	COG0791	NLP P60 protein
BIS30_07025	COG3883	PFAM NLP P60 protein
BIS30_07030	COG0457	Tetratricopeptide repeat
BIS30_07035	COG1132	(ABC) transporter
BIS30_07055	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BIS30_07055	COG0140	phosphoribosyl-ATP diphosphatase activity
BIS30_07060	COG0107	imidazoleglycerol-phosphate synthase activity
BIS30_07065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BIS30_07070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BIS30_07075	COG0131	Imidazoleglycerol-phosphate dehydratase
BIS30_07080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BIS30_07085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BIS30_07090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BIS30_07095	COG4990	cell redox homeostasis
BIS30_07100	COG5297	Belongs to the glycosyl hydrolase family 6
BIS30_07105	COG0110	maltose O-acetyltransferase activity
BIS30_07110	COG0546	phosphoglycolate phosphatase activity
BIS30_07115	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BIS30_07120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BIS30_07125	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BIS30_07130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BIS30_07135	COG0363	glucosamine-6-phosphate deaminase activity
BIS30_07145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BIS30_07150	COG1846	Transcriptional regulator
BIS30_07155	COG2124	cytochrome p450
BIS30_07165	COG1846	Transcriptional regulator
BIS30_07170	COG2814	Major facilitator Superfamily
BIS30_07175	COG1950	PFAM Membrane protein of
BIS30_07180	COG1983	PspC domain protein
BIS30_07185	COG3595	metallopeptidase activity
BIS30_07200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIS30_07210	COG4897	Protein conserved in bacteria
BIS30_07215	COG0574	Belongs to the PEP-utilizing enzyme family
BIS30_07215	COG3848	Pyruvate phosphate dikinase
BIS30_07220	COG1309	transcriptional regulator
BIS30_07225	COG2814	Major facilitator Superfamily
BIS30_07230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIS30_07240	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_07240	COG0793	Belongs to the peptidase S41A family
BIS30_07245	COG2177	Part of the ABC transporter FtsEX involved in
BIS30_07250	COG2884	Cell division ATP-binding protein ftsE
BIS30_07255	COG2010	Cytochrome c
BIS30_07260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_07265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BIS30_07270	COG0653	protein targeting
BIS30_07275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BIS30_07290	COG1516	flagellar protein fliS
BIS30_07300	COG1334	flagellar protein FlaG
BIS30_07305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BIS30_07310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BIS30_07315	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BIS30_07325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BIS30_07330	COG1256	bacterial-type flagellum assembly
BIS30_07330	COG4786	Flagellar basal body rod
BIS30_07335	COG3418	PFAM FlgN family protein
BIS30_07340	COG2747	anti-sigma28 factor FlgM
BIS30_07350	COG1040	competence protein
BIS30_07360	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BIS30_07365	COG1307	EDD domain protein, DegV family
BIS30_07370	COG2197	response regulator
BIS30_07375	COG4585	Histidine kinase
BIS30_07380	COG1739	Uncharacterized protein family UPF0029
BIS30_07385	COG1316	TRANSCRIPTIONal
BIS30_07390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIS30_07395	COG0438	transferase activity, transferring glycosyl groups
BIS30_07400	COG1215	transferase activity, transferring glycosyl groups
BIS30_07405	COG3206	protein involved in exopolysaccharide biosynthesis
BIS30_07410	COG3307	-O-antigen
BIS30_07415	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BIS30_07420	COG0438	transferase activity, transferring glycosyl groups
BIS30_07420	COG0297	glycogen (starch) synthase activity
BIS30_07425	COG2244	polysaccharide biosynthetic process
BIS30_07440	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_07440	COG2247	cell wall binding repeat
BIS30_07445	COG2247	cell wall binding repeat
BIS30_07445	COG2385	sporulation resulting in formation of a cellular spore
BIS30_07455	COG1316	TRANSCRIPTIONal
BIS30_07460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BIS30_07480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIS30_07485	COG1134	teichoic acid transport
BIS30_07490	COG1682	transport, permease protein
BIS30_07505	COG1215	transferase activity, transferring glycosyl groups
BIS30_07505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIS30_07555	COG4193	domain, Protein
BIS30_07560	COG1482	cell wall glycoprotein biosynthetic process
BIS30_07575	COG0814	amino acid
BIS30_07585	COG2814	Major facilitator Superfamily
BIS30_07590	COG1316	TRANSCRIPTIONal
BIS30_07595	COG0561	phosphatase activity
BIS30_07600	COG0791	NLP P60 protein
BIS30_07610	COG2843	Capsule synthesis protein
BIS30_07620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BIS30_07625	COG1609	Transcriptional regulator
BIS30_07630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIS30_07635	COG1869	D-ribose catabolic process
BIS30_07640	COG1129	ABC transporter
BIS30_07645	COG1172	Belongs to the binding-protein-dependent transport system permease family
BIS30_07650	COG1879	ABC-type sugar transport system periplasmic component
BIS30_07655	COG3103	Sh3 type 3 domain protein
BIS30_07665	COG2249	NAD(P)H dehydrogenase (quinone) activity
BIS30_07670	COG3527	Alpha-acetolactate decarboxylase
BIS30_07675	COG0028	Belongs to the TPP enzyme family
BIS30_07680	COG0583	DNA-binding transcription factor activity
BIS30_07685	COG5337	Spore coat protein CotH
BIS30_07695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BIS30_07705	COG0405	Gamma-glutamyltransferase
BIS30_07710	COG1522	sequence-specific DNA binding
BIS30_07715	COG2059	Chromate
BIS30_07720	COG2059	Chromate
BIS30_07730	COG0655	NAD(P)H dehydrogenase (quinone) activity
BIS30_07735	COG0583	DNA-binding transcription factor activity
BIS30_07745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_07745	COG2207	Transcriptional regulator
BIS30_07775	COG5444	nuclease activity
BIS30_07790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BIS30_07795	COG4464	protein tyrosine phosphatase activity
BIS30_07800	COG0489	protein tyrosine kinase activity
BIS30_07805	COG3944	biosynthesis protein
BIS30_07815	COG4715	Zinc finger, swim domain protein
BIS30_07820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BIS30_07825	COG0561	phosphatase activity
BIS30_07830	COG1349	DNA-binding transcription factor activity
BIS30_07835	COG0629	single-stranded DNA binding
BIS30_07850	COG3764	Sortase (surface protein transpeptidase)
BIS30_07860	COG3279	Response regulator of the LytR AlgR family
BIS30_07865	COG2972	Histidine kinase
BIS30_07865	COG0745	RESPONSE REGULATOR receiver
BIS30_07870	COG1970	mechanosensitive ion channel activity
BIS30_07875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BIS30_07880	COG0457	Tetratricopeptide repeat
BIS30_07885	COG4786	Flagellar basal body rod
BIS30_07890	COG4786	Flagellar basal body rod
BIS30_07895	COG1077	Cell shape determining protein MreB Mrl
BIS30_07900	COG1609	Transcriptional regulator
BIS30_07905	COG1846	Transcriptional regulator
BIS30_07910	COG2814	Major facilitator Superfamily
BIS30_07915	COG3420	alginic acid biosynthetic process
BIS30_07920	COG1953	Uracil, thiamine, allantoin
BIS30_07925	COG0477	Major facilitator Superfamily
BIS30_07930	COG1335	isochorismatase
BIS30_07940	COG0004	ammonium transporteR
BIS30_07945	COG0347	Belongs to the P(II) protein family
BIS30_07950	COG0671	phosphoesterase, PA-phosphatase related
BIS30_07960	COG0739	heme binding
BIS30_07965	COG1247	-acetyltransferase
BIS30_07975	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BIS30_07985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIS30_07990	COG0789	Transcriptional regulator
BIS30_08000	COG2910	NAD(P)H-binding
BIS30_08005	COG1959	2 iron, 2 sulfur cluster binding
BIS30_08010	COG0804	urea catabolic process
BIS30_08015	COG0832	Belongs to the urease beta subunit family
BIS30_08020	COG0831	urea catabolic process
BIS30_08040	COG0559	Belongs to the binding-protein-dependent transport system permease family
BIS30_08050	COG3237	CsbD-like
BIS30_08055	COG1994	Peptidase M50
BIS30_08060	COG0457	Tetratricopeptide repeat
BIS30_08065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BIS30_08070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BIS30_08080	COG2304	oxidoreductase activity
BIS30_08085	COG2304	oxidoreductase activity
BIS30_08090	COG2385	sporulation resulting in formation of a cellular spore
BIS30_08095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIS30_08105	COG4836	Membrane
BIS30_08120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BIS30_08125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BIS30_08130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BIS30_08135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIS30_08140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BIS30_08150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIS30_08155	COG0356	it plays a direct role in the translocation of protons across the membrane
BIS30_08165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BIS30_08170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BIS30_08175	COG4475	Protein of unknown function (DUF436)
BIS30_08180	COG0698	ribose 5-phosphate isomerase
BIS30_08185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIS30_08190	COG1971	Probably functions as a manganese efflux pump
BIS30_08195	COG0009	L-threonylcarbamoyladenylate synthase
BIS30_08200	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BIS30_08220	COG2890	protein-(glutamine-N5) methyltransferase activity
BIS30_08225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BIS30_08235	COG0789	Transcriptional regulator
BIS30_08240	COG0679	Auxin Efflux Carrier
BIS30_08245	COG0281	malic enzyme
BIS30_08250	COG1435	thymidine kinase activity
BIS30_08255	COG0254	rRNA binding
BIS30_08260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BIS30_08270	COG1494	fructose-1,6-bisphosphatase
BIS30_08275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIS30_08280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BIS30_08285	COG0191	fructose-bisphosphate aldolase activity
BIS30_08290	COG2204	response regulator
BIS30_08295	COG4821	SIS domain
BIS30_08300	COG0504	CTP synthase activity
BIS30_08305	COG3343	RNA polymerase activity
BIS30_08310	COG1960	acyl-CoA dehydrogenase activity
BIS30_08315	COG2181	nitrate reductase activity
BIS30_08315	COG0247	lactate metabolic process
BIS30_08320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIS30_08325	COG4294	response to UV
BIS30_08335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIS30_08340	COG1132	(ABC) transporter
BIS30_08345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIS30_08355	COG2181	nitrate reductase activity
BIS30_08360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BIS30_08365	COG1140	nitrate reductase beta subunit
BIS30_08370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BIS30_08375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIS30_08385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIS30_08390	COG2223	nitrite transmembrane transporter activity
BIS30_08395	COG0018	arginyl-trna synthetase
BIS30_08400	COG4506	Protein conserved in bacteria
BIS30_08410	COG0535	radical SAM domain protein
BIS30_08420	COG1131	(ABC) transporter
BIS30_08445	COG3391	amine dehydrogenase activity
BIS30_08455	COG0457	Tetratricopeptide repeat
BIS30_08465	COG0010	Belongs to the arginase family
BIS30_08470	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BIS30_08475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIS30_08485	COG1994	Peptidase M50
BIS30_08490	COG1942	4-Oxalocrotonate Tautomerase
BIS30_08495	COG1846	Transcriptional regulator
BIS30_08500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BIS30_08510	COG3465	dGTPase activity
BIS30_08515	COG1078	dGTPase activity
BIS30_08520	COG4844	belongs to the
BIS30_08530	COG0697	spore germination
BIS30_08535	COG0095	Lipoate-protein ligase
BIS30_08540	COG0583	DNA-binding transcription factor activity
BIS30_08545	COG0280	phosphate acetyltransferase
BIS30_08555	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_08560	COG0436	Aminotransferase
BIS30_08565	COG2814	Major facilitator Superfamily
BIS30_08570	COG0151	Belongs to the GarS family
BIS30_08575	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_08580	COG1917	Cupin 2, conserved barrel domain protein
BIS30_08585	COG0077	Prephenate dehydratase
BIS30_08590	COG2814	Major facilitator Superfamily
BIS30_08595	COG0833	amino acid
BIS30_08600	COG4187	Peptidase family M20/M25/M40
BIS30_08605	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_08610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIS30_08620	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BIS30_08625	COG1091	dTDP-4-dehydrorhamnose reductase activity
BIS30_08630	COG1088	dTDP-glucose 4,6-dehydratase activity
BIS30_08635	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BIS30_08640	COG3980	spore coat polysaccharide biosynthesis protein
BIS30_08645	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BIS30_08650	COG2089	acid synthase
BIS30_08655	COG0456	acetyltransferase
BIS30_08660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BIS30_08665	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIS30_08670	COG0463	Glycosyl transferase, family 2
BIS30_08685	COG2363	Small membrane protein
BIS30_08690	COG2233	PERMEase
BIS30_08700	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_08705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BIS30_08710	COG1216	Glycosyl transferase, family 2
BIS30_08725	COG1695	Transcriptional regulator
BIS30_08730	COG0351	phosphomethylpyrimidine kinase
BIS30_08740	COG1621	beta-fructofuranosidase activity
BIS30_08745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_08745	COG1263	PTS System
BIS30_08750	COG2116	formate transmembrane transporter activity
BIS30_08755	COG3711	transcriptional antiterminator
BIS30_08770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIS30_08775	COG0778	Nitroreductase
BIS30_08780	COG0772	Belongs to the SEDS family
BIS30_08825	COG2261	transglycosylase associated protein
BIS30_08830	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BIS30_08835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BIS30_08840	COG2246	polysaccharide biosynthetic process
BIS30_08845	COG1309	transcriptional regulator
BIS30_08855	COG3162	membrane
BIS30_08860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_08865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BIS30_08870	COG2837	iron assimilation
BIS30_08875	COG2822	iron ion transport
BIS30_08880	COG0352	thiamine-phosphate diphosphorylase activity
BIS30_08885	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BIS30_08890	COG0583	DNA-binding transcription factor activity
BIS30_08895	COG1380	Effector of murein hydrolase LrgA
BIS30_08900	COG1346	cytolysis
BIS30_08905	COG1131	(ABC) transporter
BIS30_08930	COG1346	cytolysis
BIS30_08935	COG2814	Major facilitator Superfamily
BIS30_08940	COG4895	conserved protein (DUF2196)
BIS30_08945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BIS30_08950	COG0346	lactoylglutathione lyase activity
BIS30_08960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIS30_08975	COG3711	transcriptional antiterminator
BIS30_08980	COG1442	glycosyl transferase family 8
BIS30_08985	COG5522	Integral membrane protein (intg_mem_TP0381)
BIS30_08990	COG1846	Transcriptional regulator
BIS30_08995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BIS30_09000	COG2234	aminopeptidase activity
BIS30_09005	COG2357	RelA SpoT domain protein
BIS30_09015	COG1575	Belongs to the MenA family. Type 1 subfamily
BIS30_09030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_09035	COG1696	Membrane protein involved in D-alanine export
BIS30_09040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIS30_09045	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BIS30_09050	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BIS30_09055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIS30_09060	COG1486	melibiose metabolic process
BIS30_09065	COG1447	Phosphotransferase system cellobiose-specific component IIA
BIS30_09070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIS30_09075	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIS30_09080	COG3711	transcriptional antiterminator
BIS30_09080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_09085	COG2094	Belongs to the DNA glycosylase MPG family
BIS30_09090	COG0753	catalase activity
BIS30_09095	COG2814	Major facilitator Superfamily
BIS30_09100	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BIS30_09105	COG1131	(ABC) transporter
BIS30_09125	COG1595	DNA-templated transcription, initiation
BIS30_09130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIS30_09135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BIS30_09140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BIS30_09145	COG4988	ABC transporter
BIS30_09150	COG1294	oxidase, subunit
BIS30_09155	COG1271	oxidase subunit
BIS30_09160	COG3493	citrate carrier protein
BIS30_09175	COG0726	polysaccharide deacetylase
BIS30_09190	COG3842	ATPase activity
BIS30_09195	COG2508	Transcriptional regulator
BIS30_09200	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_09205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_09215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIS30_09225	COG2195	Cleaves the N-terminal amino acid of tripeptides
BIS30_09240	COG4894	glucomannan catabolic process
BIS30_09245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIS30_09250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIS30_09255	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_09260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BIS30_09265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BIS30_09270	COG2610	gluconate transmembrane transporter activity
BIS30_09280	COG0500	methyltransferase
BIS30_09285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BIS30_09300	COG0753	catalase activity
BIS30_09300	COG0693	protein deglycase activity
BIS30_09305	COG2851	Citrate transporter
BIS30_09310	COG2323	membrane
BIS30_09320	COG2723	6-phospho-beta-galactosidase activity
BIS30_09325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_09325	COG1263	PTS System
BIS30_09325	COG2190	(PTS) system
BIS30_09330	COG3711	transcriptional antiterminator
BIS30_09340	COG2270	Major facilitator Superfamily
BIS30_09345	COG0513	Belongs to the DEAD box helicase family
BIS30_09350	COG2755	lipolytic protein G-D-S-L family
BIS30_09350	COG3401	FG-GAP repeat protein
BIS30_09460	COG0697	spore germination
BIS30_09470	COG0861	Integral membrane protein TerC family
BIS30_09475	COG0589	response to stress
BIS30_09480	COG2723	6-phospho-beta-galactosidase activity
BIS30_09485	COG2190	(PTS) system
BIS30_09485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_09485	COG1263	PTS System
BIS30_09520	COG5444	nuclease activity
BIS30_09535	COG3507	Belongs to the glycosyl hydrolase 43 family
BIS30_09540	COG0673	inositol 2-dehydrogenase activity
BIS30_09550	COG2986	histidine ammonia-lyase
BIS30_09555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BIS30_09560	COG1228	amidohydrolase
BIS30_09565	COG0010	Belongs to the arginase family
BIS30_09570	COG0833	amino acid
BIS30_09575	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BIS30_09580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BIS30_09585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BIS30_09590	COG2390	Transcriptional regulator
BIS30_09600	COG3192	ethanolamine utilization protein
BIS30_09605	COG2079	MmgE PrpD family protein
BIS30_09615	COG1126	abc transporter atp-binding protein
BIS30_09620	COG0765	amino acid transport
BIS30_09625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIS30_09645	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BIS30_09650	COG0561	phosphatase activity
BIS30_09680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_09685	COG5294	Protein conserved in bacteria
BIS30_09690	COG0577	efflux transmembrane transporter activity
BIS30_09695	COG1136	(ABC) transporter
BIS30_09700	COG2205	protein histidine kinase activity
BIS30_09705	COG0745	RESPONSE REGULATOR receiver
BIS30_09710	COG0191	fructose-bisphosphate aldolase activity
BIS30_09715	COG1082	Xylose isomerase domain protein TIM barrel
BIS30_09720	COG1082	Xylose isomerase domain protein TIM barrel
BIS30_09725	COG0673	inositol 2-dehydrogenase activity
BIS30_09730	COG2814	Major facilitator Superfamily
BIS30_09735	COG1082	Xylose isomerase domain protein TIM barrel
BIS30_09740	COG3962	Belongs to the TPP enzyme family
BIS30_09745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIS30_09755	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_09760	COG1349	DNA-binding transcription factor activity
BIS30_09765	COG0667	Aldo Keto reductase
BIS30_09780	COG2814	Major facilitator Superfamily
BIS30_09795	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_09800	COG1309	transcriptional regulator
BIS30_09805	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_09815	COG1714	RDD family
BIS30_09820	COG2311	Membrane
BIS30_09825	COG1917	Cupin 2, conserved barrel domain protein
BIS30_09830	COG1309	transcriptional regulator
BIS30_09835	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_09840	COG1846	Transcriptional regulator
BIS30_09845	COG1380	Effector of murein hydrolase LrgA
BIS30_09850	COG1346	cytolysis
BIS30_09860	COG5039	Polysaccharide pyruvyl transferase
BIS30_09865	COG1929	Belongs to the glycerate kinase type-1 family
BIS30_09870	COG1802	Transcriptional regulator
BIS30_09875	COG1070	Carbohydrate kinase
BIS30_09880	COG2610	gluconate transmembrane transporter activity
BIS30_09885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BIS30_09890	COG0450	alkyl hydroperoxide reductase
BIS30_09895	COG3634	alkyl hydroperoxide reductase activity
BIS30_09905	COG2723	6-phospho-beta-galactosidase activity
BIS30_09915	COG2188	Transcriptional regulator
BIS30_09925	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BIS30_09930	COG0270	DNA (cytosine-5-)-methyltransferase activity
BIS30_09955	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BIS30_09980	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
BIS30_09985	COG0456	acetyltransferase
BIS30_09990	COG0457	Tetratricopeptide repeat
BIS30_10000	COG0010	Belongs to the arginase family
BIS30_10005	COG0833	amino acid
BIS30_10010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BIS30_10015	COG3829	transcription factor binding
BIS30_10025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIS30_10030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BIS30_10035	COG4853	Protein conserved in bacteria
BIS30_10040	COG4863	YycH protein
BIS30_10045	COG5002	protein histidine kinase activity
BIS30_10050	COG0745	RESPONSE REGULATOR receiver
BIS30_10080	COG0346	lactoylglutathione lyase activity
BIS30_10085	COG0305	Participates in initiation and elongation during chromosome replication
BIS30_10105	COG3093	addiction module antidote protein HigA
BIS30_10110	COG2807	transmembrane transport
BIS30_10115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BIS30_10120	COG0359	binds to the 23S rRNA
BIS30_10125	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BIS30_10130	COG4241	membrane
BIS30_10140	COG5577	PFAM Coat F domain
BIS30_10145	COG1733	regulation of RNA biosynthetic process
BIS30_10150	COG1227	inorganic diphosphatase activity
BIS30_10165	COG2271	Major facilitator Superfamily
BIS30_10180	COG2814	Major facilitator Superfamily
BIS30_10185	COG0583	DNA-binding transcription factor activity
BIS30_10190	COG2153	protein acetylation
BIS30_10200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_10205	COG1733	regulation of RNA biosynthetic process
BIS30_10215	COG1846	Transcriptional regulator
BIS30_10220	COG2153	protein acetylation
BIS30_10225	COG2364	Membrane
BIS30_10230	COG1331	Highly conserved protein containing a thioredoxin domain
BIS30_10235	COG1266	CAAX protease self-immunity
BIS30_10240	COG2814	Major facilitator Superfamily
BIS30_10240	COG0477	Major facilitator Superfamily
BIS30_10245	COG0110	maltose O-acetyltransferase activity
BIS30_10250	COG0346	lactoylglutathione lyase activity
BIS30_10255	COG1609	Transcriptional regulator
BIS30_10260	COG0708	Exodeoxyribonuclease III
BIS30_10265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BIS30_10270	COG0629	single-stranded DNA binding
BIS30_10275	COG0360	Binds together with S18 to 16S ribosomal RNA
BIS30_10280	COG0012	GTP binding
BIS30_10285	COG0243	molybdopterin cofactor binding
BIS30_10290	COG4481	Protein conserved in bacteria
BIS30_10295	COG3949	Membrane
BIS30_10305	COG1475	DNA binding
BIS30_10310	COG1192	Involved in chromosome partitioning
BIS30_10320	COG1475	DNA binding
BIS30_10325	COG0357	Ribosomal RNA small subunit methyltransferase G
BIS30_10330	COG0445	tRNA wobble uridine modification
BIS30_10335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BIS30_10340	COG1847	R3H domain protein
BIS30_10345	COG0706	membrane insertase activity
BIS30_10350	COG0594	ribonuclease P activity
BIS30_10355	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BIS30_10360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BIS30_10365	COG0592	DNA-directed DNA polymerase activity
BIS30_10370	COG2501	S4 domain
BIS30_10375	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BIS30_10385	COG0187	DNA topoisomerase II activity
BIS30_10390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BIS30_10425	COG0516	GMP reductase activity
BIS30_10425	COG0517	IMP dehydrogenase activity
BIS30_10430	COG1686	Belongs to the peptidase S11 family
BIS30_10435	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BIS30_10440	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BIS30_10445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIS30_10455	COG1428	Deoxynucleoside kinase
BIS30_10460	COG1428	Deoxynucleoside kinase
BIS30_10465	COG3858	chitin binding
BIS30_10465	COG1388	LysM domain
BIS30_10470	COG1335	isochorismatase
BIS30_10475	COG0590	tRNA wobble adenosine to inosine editing
BIS30_10480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BIS30_10485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BIS30_10490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BIS30_10535	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BIS30_10540	COG3853	Toxic anion resistance protein (TelA)
BIS30_10545	COG1982	Orn Lys Arg decarboxylase major
BIS30_10550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BIS30_10555	COG3870	Protein conserved in bacteria
BIS30_10560	COG1728	Protein conserved in bacteria
BIS30_10565	COG0470	DNA polymerase III
BIS30_10570	COG1774	PSP1 C-terminal conserved region
BIS30_10575	COG4467	Involved in initiation control of chromosome replication
BIS30_10580	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BIS30_10585	COG2827	Endonuclease containing a URI domain
BIS30_10590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BIS30_10595	COG2002	toxin-antitoxin pair type II binding
BIS30_10600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIS30_10600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIS30_10605	COG0084	hydrolase, TatD family'
BIS30_10610	COG3583	domain protein
BIS30_10610	COG3584	3D domain protein
BIS30_10615	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BIS30_10620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BIS30_10630	COG4466	Protein conserved in bacteria
BIS30_10640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BIS30_10645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BIS30_10650	COG0251	oxidation-reduction process
BIS30_10655	COG2088	sporulation resulting in formation of a cellular spore
BIS30_10665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BIS30_10670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BIS30_10675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BIS30_10680	COG0193	aminoacyl-tRNA hydrolase activity
BIS30_10690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BIS30_10695	COG2002	toxin-antitoxin pair type II binding
BIS30_10700	COG2244	polysaccharide biosynthetic process
BIS30_10705	COG3956	TIGRFAM MazG family protein
BIS30_10710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BIS30_10725	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BIS30_10730	COG1098	S1 RNA binding domain
BIS30_10745	COG2208	phosphoserine phosphatase activity
BIS30_10750	COG2304	oxidoreductase activity
BIS30_10755	COG0515	serine threonine protein kinase
BIS30_10770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIS30_10775	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BIS30_10780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BIS30_10785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BIS30_10790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BIS30_10795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BIS30_10800	COG0512	Glutamine amidotransferase of anthranilate synthase
BIS30_10805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIS30_10810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BIS30_10815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BIS30_10820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BIS30_10825	COG1396	sequence-specific DNA binding
BIS30_10830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIS30_10835	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BIS30_10860	COG4463	regulation of RNA biosynthetic process
BIS30_10865	COG3880	PFAM UvrB UvrC protein
BIS30_10870	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BIS30_10875	COG0542	response to heat
BIS30_10880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BIS30_10885	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BIS30_10890	COG4956	integral membrane protein (PIN domain superfamily)
BIS30_10895	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BIS30_10900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BIS30_10905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BIS30_10915	COG1045	serine acetyltransferase
BIS30_10920	COG0215	cysteine-tRNA ligase activity
BIS30_10925	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BIS30_10930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIS30_10935	COG3688	RNA-binding protein containing a PIN domain
BIS30_10940	COG1595	DNA-templated transcription, initiation
BIS30_10945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BIS30_10950	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIS30_10955	COG0250	Participates in transcription elongation, termination and antitermination
BIS30_10960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BIS30_10965	COG0081	regulation of translation
BIS30_10970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BIS30_10975	COG0222	ribosome binding
BIS30_10980	COG2813	Specifically methylates the guanine in position
BIS30_10985	COG0085	RNA polymerase activity
BIS30_10990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BIS30_10995	COG1358	cellular component organization or biogenesis
BIS30_11000	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BIS30_11005	COG0049	tRNA binding
BIS30_11010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BIS30_11015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BIS30_11020	COG0596	Alpha beta hydrolase
BIS30_11025	COG0051	transcription antitermination factor activity, RNA binding
BIS30_11030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BIS30_11035	COG0088	Forms part of the polypeptide exit tunnel
BIS30_11040	COG0089	rRNA binding
BIS30_11045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BIS30_11050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BIS30_11055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BIS30_11060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BIS30_11065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BIS30_11070	COG0255	Belongs to the universal ribosomal protein uL29 family
BIS30_11075	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BIS30_11080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BIS30_11090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BIS30_11100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BIS30_11105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BIS30_11110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BIS30_11120	COG1841	ribosomal large subunit assembly
BIS30_11125	COG0200	Binds to the 23S rRNA
BIS30_11130	COG0201	protein transport
BIS30_11135	COG0563	adenylate kinase activity
BIS30_11140	COG0024	Methionine aminopeptidase
BIS30_11145	COG2163	COG2163 Ribosomal protein L14E L6E L27E
BIS30_11150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BIS30_11155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BIS30_11165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BIS30_11170	COG0202	RNA polymerase activity
BIS30_11175	COG0203	ribosomal protein L17
BIS30_11180	COG1122	ATPase activity
BIS30_11185	COG1122	ATPase activity
BIS30_11190	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIS30_11195	COG0101	tRNA pseudouridine synthase activity
BIS30_11215	COG2226	methyltransferase
BIS30_11225	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_11230	COG0489	protein tyrosine kinase activity
BIS30_11240	COG2194	sulfuric ester hydrolase activity
BIS30_11245	COG0726	polysaccharide deacetylase
BIS30_11315	COG0659	secondary active sulfate transmembrane transporter activity
BIS30_11320	COG0385	Bile acid
BIS30_11325	COG2819	hydrolase of the alpha beta superfamily
BIS30_11330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_11335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_11340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_11345	COG2207	Transcriptional regulator
BIS30_11345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_11350	COG3876	Protein conserved in bacteria
BIS30_11355	COG1472	Belongs to the glycosyl hydrolase 3 family
BIS30_11360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIS30_11365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_11365	COG1263	PTS System
BIS30_11370	COG1737	Transcriptional regulator
BIS30_11375	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BIS30_11380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_11385	COG1683	Conserved Protein
BIS30_11415	COG1595	DNA-templated transcription, initiation
BIS30_11420	COG5662	AntiSigma factor
BIS30_11425	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BIS30_11430	COG4856	YbbR-like protein
BIS30_11435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIS30_11445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BIS30_11450	COG3002	Belongs to the UPF0753 family
BIS30_11465	COG5609	conserved protein (DUF2294)
BIS30_11470	COG0596	Alpha beta hydrolase
BIS30_11475	COG0745	RESPONSE REGULATOR receiver
BIS30_11480	COG0642	Histidine kinase
BIS30_11490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BIS30_11500	COG2211	Major facilitator Superfamily
BIS30_11560	COG0515	serine threonine protein kinase
BIS30_11575	COG1113	amino acid transport
BIS30_11590	COG2602	Beta-lactamase
BIS30_11595	COG2124	cytochrome p450
BIS30_11605	COG1283	sodium-dependent phosphate transmembrane transporter activity
BIS30_11610	COG0584	glycerophosphoryl diester phosphodiesterase
BIS30_11615	COG2271	Major facilitator Superfamily
BIS30_11625	COG1846	Transcriptional regulator
BIS30_11625	COG0456	acetyltransferase
BIS30_11630	COG2271	Major facilitator Superfamily
BIS30_11645	COG0697	spore germination
BIS30_11650	COG2207	Transcriptional regulator
BIS30_11650	COG1917	Cupin 2, conserved barrel domain protein
BIS30_11655	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BIS30_11660	COG3591	Belongs to the peptidase S1B family
BIS30_11670	COG0596	Alpha beta hydrolase
BIS30_11675	COG1183	phosphatidylcholine synthase activity
BIS30_11680	COG0586	Pfam SNARE associated Golgi protein
BIS30_11685	COG0688	phosphatidylethanolamine metabolic process
BIS30_11695	COG2312	Erythromycin esterase
BIS30_11705	COG1301	dicarboxylic acid transport
BIS30_11715	COG0363	glucosamine-6-phosphate deaminase activity
BIS30_11730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIS30_11735	COG0833	amino acid
BIS30_11740	COG2040	homocysteine
BIS30_11750	COG1115	amino acid carrier protein
BIS30_11755	COG2066	Belongs to the glutaminase family
BIS30_11760	COG4191	Histidine kinase
BIS30_11765	COG0784	Response regulator, receiver
BIS30_11775	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_11780	COG2271	Major facilitator Superfamily
BIS30_11785	COG4948	Mandelate Racemase Muconate Lactonizing
BIS30_11790	COG2186	Transcriptional regulator
BIS30_11795	COG2721	sulfolactate sulfo-lyase activity
BIS30_11800	COG3173	Aminoglycoside phosphotransferase
BIS30_11810	COG0745	RESPONSE REGULATOR receiver
BIS30_11815	COG2205	protein histidine kinase activity
BIS30_11820	COG1131	(ABC) transporter
BIS30_11840	COG3773	Cell wall hydrolase
BIS30_11845	COG2304	oxidoreductase activity
BIS30_11855	COG3540	Alkaline phosphatase
BIS30_11860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BIS30_11865	COG0805	protein transport
BIS30_11870	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BIS30_11875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BIS30_11880	COG0477	Major facilitator Superfamily
BIS30_11885	COG1309	transcriptional regulator
BIS30_11890	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BIS30_11895	COG1714	RDD family
BIS30_11900	COG1405	negative regulation of cell septum assembly
BIS30_11900	COG3012	SEC-C Motif Domain Protein
BIS30_11905	COG3290	protein histidine kinase activity
BIS30_11910	COG1668	transmembrane transport
BIS30_11915	COG0667	Aldo Keto reductase
BIS30_11925	COG1595	DNA-templated transcription, initiation
BIS30_11940	COG2801	Transposase and inactivated derivatives
BIS30_11945	COG1595	DNA-templated transcription, initiation
BIS30_11950	COG1876	peptidase activity
BIS30_11955	COG0457	Tetratricopeptide repeat
BIS30_11960	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_11965	COG0366	Alpha amylase catalytic
BIS30_11970	COG0803	Belongs to the bacterial solute-binding protein 9 family
BIS30_11975	COG1121	(ABC) transporter
BIS30_11980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BIS30_11985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIS30_11990	COG2310	stress, protein
BIS30_11995	COG2310	stress, protein
BIS30_12000	COG2310	stress, protein
BIS30_12005	COG0861	Integral membrane protein TerC family
BIS30_12015	COG3853	Toxic anion resistance protein (TelA)
BIS30_12020	COG0477	Major facilitator Superfamily
BIS30_12025	COG0640	Transcriptional regulator
BIS30_12030	COG4175	Glycine betaine
BIS30_12030	COG0517	IMP dehydrogenase activity
BIS30_12035	COG4176	ABC-type proline glycine betaine transport system permease component
BIS30_12040	COG2113	Glycine betaine
BIS30_12045	COG1473	amidohydrolase
BIS30_12050	COG1288	antiporter activity
BIS30_12065	COG0366	Alpha amylase catalytic
BIS30_12070	COG0039	L-malate dehydrogenase activity
BIS30_12075	COG1620	l-lactate permease
BIS30_12080	COG2814	Major facilitator Superfamily
BIS30_12085	COG1846	Transcriptional regulator
BIS30_12090	COG1280	lysine exporter protein (LysE YggA)
BIS30_12095	COG3403	YqcI/YcgG family
BIS30_12100	COG1113	amino acid transport
BIS30_12105	COG3665	Urea carboxylase-associated protein
BIS30_12110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BIS30_12115	COG1660	Displays ATPase and GTPase activities
BIS30_12120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BIS30_12125	COG2226	methyltransferase
BIS30_12130	COG0583	DNA-binding transcription factor activity
BIS30_12135	COG3458	cephalosporin-C deacetylase activity
BIS30_12140	COG3541	Predicted nucleotidyltransferase
BIS30_12145	COG0506	proline dehydrogenase activity
BIS30_12150	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_12155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_12160	COG2508	Transcriptional regulator
BIS30_12165	COG3689	TIGRFAM TIGR03943 family protein
BIS30_12170	COG0701	Predicted permease
BIS30_12175	COG2267	carboxylic ester hydrolase activity
BIS30_12180	COG0492	ferredoxin-NADP+ reductase activity
BIS30_12185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BIS30_12185	COG1587	Uroporphyrinogen-III synthase
BIS30_12190	COG2146	nitrite reductase [NAD(P)H] activity
BIS30_12195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BIS30_12200	COG0243	molybdopterin cofactor binding
BIS30_12205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BIS30_12210	COG2223	nitrite transmembrane transporter activity
BIS30_12215	COG1469	GTP cyclohydrolase I activity
BIS30_12220	COG1376	ErfK ybiS ycfS ynhG family protein
BIS30_12230	COG0523	cobalamin synthesis protein
BIS30_12235	COG0765	amino acid transport
BIS30_12240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIS30_12250	COG1714	RDD family
BIS30_12260	COG1846	Transcriptional regulator
BIS30_12270	COG3842	ATPase activity
BIS30_12275	COG2723	6-phospho-beta-galactosidase activity
BIS30_12285	COG3209	COG3209 Rhs family protein
BIS30_12295	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BIS30_12300	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BIS30_12305	COG1733	regulation of RNA biosynthetic process
BIS30_12315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_12320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_12325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_12330	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
BIS30_12335	COG2814	Major facilitator Superfamily
BIS30_12345	COG0697	spore germination
BIS30_12350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_12360	COG2364	Membrane
BIS30_12365	COG1126	abc transporter atp-binding protein
BIS30_12370	COG0765	amino acid transport
BIS30_12375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIS30_12380	COG0583	DNA-binding transcription factor activity
BIS30_12385	COG0163	prenyltransferase activity
BIS30_12390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BIS30_12405	COG0596	Alpha beta hydrolase
BIS30_12410	COG3104	oligopeptide transport
BIS30_12415	COG5434	Belongs to the glycosyl hydrolase 28 family
BIS30_12425	COG0697	spore germination
BIS30_12435	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BIS30_12440	COG1136	(ABC) transporter
BIS30_12445	COG0577	efflux transmembrane transporter activity
BIS30_12450	COG0745	RESPONSE REGULATOR receiver
BIS30_12455	COG5002	protein histidine kinase activity
BIS30_12455	COG3850	Histidine kinase
BIS30_12460	COG0457	Tetratricopeptide repeat
BIS30_12475	COG0527	aspartate kinase activity
BIS30_12480	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_12485	COG4605	iron ion homeostasis
BIS30_12490	COG4604	ABC transporter, ATP-binding protein
BIS30_12495	COG4607	ABC-type enterochelin transport system periplasmic component
BIS30_12500	COG2814	Major facilitator Superfamily
BIS30_12505	COG1309	transcriptional regulator
BIS30_12510	COG0778	Nitroreductase
BIS30_12515	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BIS30_12520	COG0640	Transcriptional regulator
BIS30_12525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_12530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BIS30_12535	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_12540	COG4975	Glucose uptake
BIS30_12545	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_12550	COG4549	nuclear export factor GLE1
BIS30_12555	COG2372	response to copper ion
BIS30_12555	COG1276	copper resistance
BIS30_12560	COG1349	DNA-binding transcription factor activity
BIS30_12570	COG2213	PTS system mannitol-specific
BIS30_12575	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_12580	COG0246	Mannitol dehydrogenase
BIS30_12585	COG0473	3-isopropylmalate dehydrogenase activity
BIS30_12590	COG0681	Belongs to the peptidase S26 family
BIS30_12595	COG0412	Dienelactone hydrolase
BIS30_12600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BIS30_12610	COG0561	phosphatase activity
BIS30_12615	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BIS30_12620	COG1914	H( )-stimulated, divalent metal cation uptake system
BIS30_12625	COG4336	lyase activity
BIS30_12630	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BIS30_12635	COG1984	allophanate hydrolase subunit 2
BIS30_12640	COG1414	Transcriptional regulator
BIS30_12645	COG2755	lipolytic protein G-D-S-L family
BIS30_12655	COG2329	Antibiotic biosynthesis monooxygenase
BIS30_12660	COG0768	penicillin binding
BIS30_12665	COG4989	oxidoreductase activity
BIS30_12670	COG3711	transcriptional antiterminator
BIS30_12675	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_12680	COG2226	methyltransferase
BIS30_12685	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_12690	COG1917	Cupin 2, conserved barrel domain protein
BIS30_12695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_12700	COG3871	stress protein (general stress protein 26)
BIS30_12710	COG2814	Major facilitator Superfamily
BIS30_12715	COG1522	sequence-specific DNA binding
BIS30_12720	COG0551	DNA topoisomerase type I activity
BIS30_12720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIS30_12725	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BIS30_12730	COG3706	GGDEF domain
BIS30_12735	COG5298	Protein conserved in bacteria
BIS30_12740	COG1215	transferase activity, transferring glycosyl groups
BIS30_12750	COG0531	amino acid
BIS30_12755	COG0494	nUDIX hydrolase
BIS30_12760	COG0028	Belongs to the TPP enzyme family
BIS30_12770	COG1914	H( )-stimulated, divalent metal cation uptake system
BIS30_12775	COG2261	transglycosylase associated protein
BIS30_12780	COG4876	unkown
BIS30_12785	COG2217	Heavy metal translocating P-type atpase
BIS30_12790	COG3729	General stress protein
BIS30_12800	COG2329	Antibiotic biosynthesis monooxygenase
BIS30_12805	COG3546	catalase activity
BIS30_12810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BIS30_12815	COG3290	protein histidine kinase activity
BIS30_12820	COG4565	transcriptional regulatory protein
BIS30_12825	COG1301	dicarboxylic acid transport
BIS30_12830	COG0628	permease
BIS30_12835	COG1301	dicarboxylic acid transport
BIS30_12840	COG1131	(ABC) transporter
BIS30_12845	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BIS30_12855	COG1960	acyl-CoA dehydrogenase activity
BIS30_12870	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIS30_12875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_12880	COG1181	Belongs to the D-alanine--D-alanine ligase family
BIS30_12885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIS30_12890	COG0513	Belongs to the DEAD box helicase family
BIS30_12895	COG3402	PFAM membrane-flanked domain
BIS30_12900	COG3428	Bacterial PH domain
BIS30_12905	COG0705	Rhomboid family
BIS30_12910	COG0736	holo-[acyl-carrier-protein] synthase activity
BIS30_12915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BIS30_12920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BIS30_12925	COG0864	Transcriptional regulator
BIS30_12930	COG2337	Toxic component of a toxin-antitoxin (TA) module
BIS30_12935	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_12940	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_12945	COG2172	sigma factor antagonist activity
BIS30_12950	COG2208	phosphoserine phosphatase activity
BIS30_12955	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_12960	COG2172	sigma factor antagonist activity
BIS30_12965	COG1191	sigma factor activity
BIS30_12970	COG2208	phosphoserine phosphatase activity
BIS30_12975	COG2183	response to ionizing radiation
BIS30_12985	COG3091	SprT-like family
BIS30_13030	COG0789	Transcriptional regulator
BIS30_13035	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_13040	COG0667	Aldo Keto reductase
BIS30_13045	COG4221	oxidoreductase activity
BIS30_13050	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_13060	COG4221	oxidoreductase activity
BIS30_13065	COG3239	Fatty acid desaturase
BIS30_13070	COG1278	Cold shock
BIS30_13075	COG1329	Transcriptional regulator
BIS30_13085	COG1396	sequence-specific DNA binding
BIS30_13090	COG3708	Transcriptional regulator
BIS30_13090	COG2207	Transcriptional regulator
BIS30_13100	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BIS30_13115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BIS30_13120	COG1522	sequence-specific DNA binding
BIS30_13125	COG0697	spore germination
BIS30_13130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_13135	COG2030	dehydratase
BIS30_13140	COG3545	Serine hydrolase
BIS30_13145	COG1733	regulation of RNA biosynthetic process
BIS30_13150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_13160	COG0640	Transcriptional regulator
BIS30_13165	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BIS30_13170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIS30_13175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_13180	COG0697	spore germination
BIS30_13185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_13190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BIS30_13195	COG0640	Transcriptional regulator
BIS30_13200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BIS30_13215	COG4585	Histidine kinase
BIS30_13220	COG2197	response regulator
BIS30_13225	COG2409	Drug exporters of the RND superfamily
BIS30_13235	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BIS30_13240	COG1114	Component of the transport system for branched-chain amino acids
BIS30_13250	COG1811	Na channel or pump
BIS30_13255	COG4978	Transcriptional regulator
BIS30_13255	COG0789	Transcriptional regulator
BIS30_13260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIS30_13265	COG0778	Nitroreductase
BIS30_13270	COG0346	lactoylglutathione lyase activity
BIS30_13275	COG2259	Doxx family
BIS30_13280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_13285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_13305	COG2323	membrane
BIS30_13310	COG0071	Belongs to the small heat shock protein (HSP20) family
BIS30_13325	COG1309	transcriptional regulator
BIS30_13335	COG0456	acetyltransferase
BIS30_13345	COG0673	inositol 2-dehydrogenase activity
BIS30_13350	COG1609	Transcriptional regulator
BIS30_13355	COG2814	Major facilitator Superfamily
BIS30_13360	COG2814	Major facilitator Superfamily
BIS30_13365	COG2814	Major facilitator Superfamily
BIS30_13375	COG2814	Major facilitator Superfamily
BIS30_13390	COG1113	amino acid transport
BIS30_13395	COG2318	DinB family
BIS30_13400	COG1846	Transcriptional regulator
BIS30_13405	COG1033	growth of symbiont in host cell
BIS30_13405	COG2409	Drug exporters of the RND superfamily
BIS30_13410	COG0778	Nitroreductase
BIS30_13415	COG1846	Transcriptional regulator
BIS30_13420	COG1396	sequence-specific DNA binding
BIS30_13435	COG2814	Major facilitator Superfamily
BIS30_13440	COG0730	response to heat
BIS30_13445	COG1802	Transcriptional regulator
BIS30_13450	COG3858	chitin binding
BIS30_13450	COG1388	LysM domain
BIS30_13455	COG1819	glycosyl
BIS30_13470	COG1785	Belongs to the alkaline phosphatase family
BIS30_13480	COG0454	-acetyltransferase
BIS30_13485	COG1078	dGTPase activity
BIS30_13490	COG1388	LysM domain
BIS30_13495	COG2814	Major facilitator Superfamily
BIS30_13500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIS30_13505	COG1447	Phosphotransferase system cellobiose-specific component IIA
BIS30_13510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BIS30_13515	COG2723	6-phospho-beta-galactosidase activity
BIS30_13520	COG2188	Transcriptional regulator
BIS30_13525	COG1940	carbohydrate kinase activity
BIS30_13530	COG1482	cell wall glycoprotein biosynthetic process
BIS30_13535	COG4124	Belongs to the glycosyl hydrolase 26 family
BIS30_13580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BIS30_13585	COG0802	atpase or kinase
BIS30_13590	COG1214	PFAM Peptidase M22, glycoprotease
BIS30_13595	COG0456	acetyltransferase
BIS30_13600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BIS30_13605	COG0488	(ABC) transporter
BIS30_13610	COG0315	cyclic pyranopterin monophosphate synthase activity
BIS30_13615	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BIS30_13620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BIS30_13625	COG0805	protein transport
BIS30_13635	COG1266	CAAX protease self-immunity
BIS30_13640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BIS30_13645	COG0459	protein refolding
BIS30_13650	COG1073	alpha beta
BIS30_13655	COG0457	Tetratricopeptide repeat
BIS30_13660	COG1063	alcohol dehydrogenase
BIS30_13665	COG2211	Major facilitator Superfamily
BIS30_13670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIS30_13675	COG1842	Phage shock protein A
BIS30_13680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BIS30_13685	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BIS30_13690	COG4260	virion core protein, lumpy skin disease virus
BIS30_13700	COG2814	Major facilitator Superfamily
BIS30_13705	COG1063	alcohol dehydrogenase
BIS30_13710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BIS30_13715	COG0823	Involved in the tonB-independent uptake of proteins
BIS30_13725	COG2801	Transposase and inactivated derivatives
BIS30_13740	COG2267	carboxylic ester hydrolase activity
BIS30_13750	COG2132	Multicopper oxidase
BIS30_13755	COG1113	amino acid transport
BIS30_13765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BIS30_13770	COG0714	Associated with various cellular activities
BIS30_13775	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BIS30_13780	COG1305	Transglutaminase-like
BIS30_13790	COG2252	PERMEase
BIS30_13795	COG3064	Membrane
BIS30_13805	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BIS30_13815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BIS30_13820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BIS30_13825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BIS30_13830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BIS30_13835	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIS30_13840	COG0047	phosphoribosylformylglycinamidine synthase activity
BIS30_13845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIS30_13850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BIS30_13855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BIS30_13860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BIS30_13865	COG0138	bifunctional purine biosynthesis protein purh
BIS30_13870	COG0151	Belongs to the GarS family
BIS30_13875	COG1522	sequence-specific DNA binding
BIS30_13880	COG0531	amino acid
BIS30_13890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BIS30_13895	COG1470	cell adhesion involved in biofilm formation
BIS30_13900	COG4496	protein, YerC YecD
BIS30_13905	COG0069	glutamate synthase activity
BIS30_13910	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BIS30_13915	COG0210	DNA helicase
BIS30_13920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BIS30_13935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BIS30_13940	COG1285	pathogenesis
BIS30_13945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_13950	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIS30_13955	COG0154	amidase activity
BIS30_13960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BIS30_13965	COG1309	transcriptional regulator
BIS30_13970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIS30_13975	COG1597	lipid kinase activity
BIS30_13980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIS30_13985	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BIS30_13990	COG0732	type I restriction modification DNA specificity domain
BIS30_13995	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BIS30_14015	COG5444	nuclease activity
BIS30_14020	COG3391	amine dehydrogenase activity
BIS30_14025	COG0457	Tetratricopeptide repeat
BIS30_14035	COG0217	transcriptional regulatory protein
BIS30_14045	COG1309	transcriptional regulator
BIS30_14050	COG3631	Ketosteroid isomerase-related protein
BIS30_14055	COG0702	epimerase
BIS30_14060	COG2159	amidohydrolase
BIS30_14065	COG1309	transcriptional regulator
BIS30_14080	COG3546	catalase activity
BIS30_14085	COG0454	-acetyltransferase
BIS30_14095	COG5578	integral membrane protein
BIS30_14100	COG2972	Histidine kinase
BIS30_14105	COG2207	Transcriptional regulator
BIS30_14105	COG4753	response regulator
BIS30_14110	COG1653	transport
BIS30_14115	COG1175	transmembrane transport
BIS30_14120	COG0395	ABC-type sugar transport system, permease component
BIS30_14125	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BIS30_14130	COG2207	Transcriptional regulator
BIS30_14135	COG2755	lipolytic protein G-D-S-L family
BIS30_14145	COG5578	integral membrane protein
BIS30_14150	COG3401	FG-GAP repeat protein
BIS30_14155	COG3401	FG-GAP repeat protein
BIS30_14160	COG2755	lipolytic protein G-D-S-L family
BIS30_14165	COG1874	Beta-galactosidase
BIS30_14175	COG1653	transport
BIS30_14180	COG4209	transmembrane transport
BIS30_14185	COG0395	ABC-type sugar transport system, permease component
BIS30_14190	COG1486	melibiose metabolic process
BIS30_14195	COG2323	membrane
BIS30_14200	COG2329	Antibiotic biosynthesis monooxygenase
BIS30_14205	COG0346	lactoylglutathione lyase activity
BIS30_14215	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_14220	COG5583	Uncharacterized small protein (DUF2292)
BIS30_14225	COG0670	Belongs to the BI1 family
BIS30_14230	COG1846	Transcriptional regulator
BIS30_14235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BIS30_14245	COG2124	cytochrome p450
BIS30_14245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BIS30_14250	COG1368	sulfuric ester hydrolase activity
BIS30_14255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BIS30_14260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BIS30_14265	COG1442	glycosyl transferase family 8
BIS30_14270	COG1216	Glycosyl transferase, family 2
BIS30_14275	COG1442	glycosyl transferase family 8
BIS30_14280	COG2223	nitrite transmembrane transporter activity
BIS30_14285	COG1011	Hydrolase
BIS30_14290	COG0531	amino acid
BIS30_14295	COG1012	belongs to the aldehyde dehydrogenase family
BIS30_14300	COG0840	transmembrane signaling receptor activity
BIS30_14305	COG0488	(ABC) transporter
BIS30_14315	COG0789	Transcriptional regulator
BIS30_14320	COG2814	Major facilitator Superfamily
BIS30_14335	COG0488	(ABC) transporter
BIS30_14340	COG0513	Belongs to the DEAD box helicase family
BIS30_14345	COG0456	acetyltransferase
BIS30_14350	COG2130	NADP-dependent
BIS30_14355	COG1120	ATPase activity
BIS30_14360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_14365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_14370	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BIS30_14385	COG3866	Pectate lyase
BIS30_14390	COG0471	metal ion transport
BIS30_14395	COG3290	protein histidine kinase activity
BIS30_14400	COG4565	transcriptional regulatory protein
BIS30_14405	COG3181	Tripartite tricarboxylate transporter family receptor
BIS30_14410	COG2851	Citrate transporter
BIS30_14415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_14420	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BIS30_14425	COG1254	Belongs to the acylphosphatase family
BIS30_14430	COG2258	MOSC domain
BIS30_14450	COG0024	Methionine aminopeptidase
BIS30_14455	COG1263	PTS System
BIS30_14455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_14460	COG1368	sulfuric ester hydrolase activity
BIS30_14470	COG1115	amino acid carrier protein
BIS30_14475	COG0531	amino acid
BIS30_14490	COG0697	spore germination
BIS30_14495	COG1263	PTS System
BIS30_14495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_14500	COG0366	Alpha amylase catalytic
BIS30_14505	COG2188	Transcriptional regulator
BIS30_14510	COG0778	Nitroreductase
BIS30_14515	COG0737	Belongs to the 5'-nucleotidase family
BIS30_14520	COG0693	protein deglycase activity
BIS30_14525	COG2814	Major facilitator Superfamily
BIS30_14530	COG4840	Belongs to the UPF0435 family
BIS30_14535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIS30_14540	COG4980	gas vesicle protein
BIS30_14545	COG1295	ribonuclease BN
BIS30_14555	COG0477	Major facilitator Superfamily
BIS30_14565	COG0387	Pfam Sodium calcium exchanger
BIS30_14575	COG0668	transmembrane transport
BIS30_14580	COG0535	radical SAM domain protein
BIS30_14590	COG0726	polysaccharide deacetylase
BIS30_14595	COG2084	Dehydrogenase
BIS30_14600	COG0598	Magnesium transport protein CorA
BIS30_14605	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BIS30_14615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIS30_14620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIS30_14630	COG4637	Psort location Cytoplasmic, score
BIS30_14640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BIS30_14645	COG0022	dehydrogenase e1 component
BIS30_14655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIS30_14660	COG3284	Transcriptional regulator
BIS30_14670	COG1742	UPF0060 membrane protein
BIS30_14690	COG4842	Belongs to the WXG100 family
BIS30_14695	COG1486	melibiose metabolic process
BIS30_14700	COG1737	Transcriptional regulator
BIS30_14705	COG1263	PTS System
BIS30_14705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_14715	COG1132	(ABC) transporter
BIS30_14720	COG2259	Doxx family
BIS30_14725	COG2514	catechol 2,3-dioxygenase activity
BIS30_14730	COG4585	Histidine kinase
BIS30_14735	COG2197	response regulator
BIS30_14740	COG1131	(ABC) transporter
BIS30_14745	COG1511	domain protein
BIS30_14745	COG0842	Transport permease protein
BIS30_14750	COG0842	Transport permease protein
BIS30_14760	COG1695	Transcriptional regulator
BIS30_14765	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BIS30_14770	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
BIS30_14775	COG2318	DinB family
BIS30_14780	COG2814	Major facilitator Superfamily
BIS30_14785	COG1846	Transcriptional regulator
BIS30_14790	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BIS30_14790	COG0392	lysyltransferase activity
BIS30_14795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BIS30_14800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_14805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIS30_14815	COG0778	Nitroreductase
BIS30_14830	COG1090	epimerase
BIS30_14835	COG2137	regulation of response to DNA damage stimulus
BIS30_14850	COG2814	Major facilitator Superfamily
BIS30_14865	COG3103	Sh3 type 3 domain protein
BIS30_14870	COG5658	integral membrane protein
BIS30_14875	COG0596	Alpha beta hydrolase
BIS30_14880	COG0463	Glycosyl transferase, family 2
BIS30_14885	COG4485	Bacterial membrane protein, YfhO
BIS30_14890	COG1988	membrane-bound metal-dependent
BIS30_14895	COG1194	a g-specific adenine glycosylase
BIS30_14905	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_14920	COG3557	Belongs to the UPF0374 family
BIS30_14925	COG1132	(ABC) transporter
BIS30_14930	COG4129	membrane
BIS30_14935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BIS30_14940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BIS30_14945	COG0735	belongs to the Fur family
BIS30_15065	COG4326	sporulation control protein
BIS30_15075	COG5577	PFAM Coat F domain
BIS30_15080	COG3340	Belongs to the peptidase S51 family
BIS30_15085	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BIS30_15095	COG0753	catalase activity
BIS30_15100	COG1116	anion transmembrane transporter activity
BIS30_15105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BIS30_15110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BIS30_15115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIS30_15125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIS30_15135	COG1476	TRANSCRIPTIONal
BIS30_15145	COG3382	B3 4 domain protein
BIS30_15150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BIS30_15160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BIS30_15165	COG0789	Transcriptional regulator
BIS30_15170	COG1664	Polymer-forming cytoskeletal
BIS30_15175	COG1664	Polymer-forming cytoskeletal
BIS30_15180	COG2766	serine protein kinase
BIS30_15185	COG2718	Belongs to the UPF0229 family
BIS30_15190	COG1846	Transcriptional regulator
BIS30_15195	COG1566	PFAM secretion protein HlyD family protein
BIS30_15200	COG2814	Major facilitator Superfamily
BIS30_15205	COG0655	NAD(P)H dehydrogenase (quinone) activity
BIS30_15220	COG1725	Transcriptional regulator
BIS30_15225	COG1131	(ABC) transporter
BIS30_15230	COG1131	(ABC) transporter
BIS30_15240	COG1278	Cold shock
BIS30_15245	COG1464	Belongs to the NlpA lipoprotein family
BIS30_15250	COG3706	GGDEF domain
BIS30_15255	COG1823	symporter activity
BIS30_15275	COG5577	PFAM Coat F domain
BIS30_15280	COG1525	nuclease
BIS30_15280	COG4085	toxin activity
BIS30_15280	COG0737	Belongs to the 5'-nucleotidase family
BIS30_15285	COG3764	Sortase (surface protein transpeptidase)
BIS30_15290	COG0564	pseudouridine synthase activity
BIS30_15300	COG0517	IMP dehydrogenase activity
BIS30_15305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIS30_15310	COG3153	acetyltransferase
BIS30_15310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BIS30_15320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BIS30_15325	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BIS30_15330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIS30_15335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIS30_15340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BIS30_15345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIS30_15350	COG4585	Histidine kinase
BIS30_15350	COG2203	Gaf domain
BIS30_15355	COG2197	response regulator
BIS30_15360	COG0431	NADPH-dependent FMN reductase
BIS30_15375	COG1388	LysM domain
BIS30_15375	COG0791	NLP P60 protein
BIS30_15380	COG1959	2 iron, 2 sulfur cluster binding
BIS30_15385	COG0668	transmembrane transport
BIS30_15390	COG2719	SpoVR family
BIS30_15395	COG1785	Belongs to the alkaline phosphatase family
BIS30_15400	COG1388	LysM domain
BIS30_15400	COG0791	NLP P60 protein
BIS30_15405	COG0583	DNA-binding transcription factor activity
BIS30_15410	COG0372	Belongs to the citrate synthase family
BIS30_15415	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_15420	COG0531	amino acid
BIS30_15425	COG0733	neurotransmitter:sodium symporter activity
BIS30_15430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_15435	COG0456	acetyltransferase
BIS30_15450	COG1595	DNA-templated transcription, initiation
BIS30_15455	COG0667	Aldo Keto reductase
BIS30_15460	COG0204	Acyl-transferase
BIS30_15465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIS30_15475	COG1253	flavin adenine dinucleotide binding
BIS30_15480	COG0789	Transcriptional regulator
BIS30_15485	COG0436	Aminotransferase
BIS30_15490	COG1253	flavin adenine dinucleotide binding
BIS30_15495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIS30_15500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIS30_15505	COG0584	glycerophosphoryl diester phosphodiesterase
BIS30_15515	COG0668	transmembrane transport
BIS30_15520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BIS30_15525	COG0726	polysaccharide deacetylase
BIS30_15530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIS30_15535	COG1757	Na H antiporter
BIS30_15540	COG0589	response to stress
BIS30_15550	COG1132	(ABC) transporter
BIS30_15555	COG1132	(ABC) transporter
BIS30_15560	COG0702	epimerase
BIS30_15585	COG0189	ligase activity
BIS30_15590	COG4399	Belongs to the UPF0754 family
BIS30_15595	COG3679	Belongs to the UPF0342 family
BIS30_15600	COG4335	DNA alkylation repair
BIS30_15610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BIS30_15615	COG0475	glutathione-regulated potassium exporter activity
BIS30_15620	COG0490	domain, Protein
BIS30_15630	COG1024	Enoyl-CoA hydratase
BIS30_15640	COG4152	abc transporter atp-binding protein
BIS30_15645	COG1668	transmembrane transport
BIS30_15650	COG0420	3'-5' exonuclease activity
BIS30_15655	COG4717	serine-type aminopeptidase activity
BIS30_15660	COG3481	metal-dependent phosphohydrolase, HD sub domain
BIS30_15670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BIS30_15695	COG1846	Transcriptional regulator
BIS30_15700	COG4980	gas vesicle protein
BIS30_15715	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BIS30_15720	COG0537	adenosine 5'-monophosphoramidase activity
BIS30_15725	COG1131	(ABC) transporter
BIS30_15730	COG4473	ABC transporter
BIS30_15740	COG1473	amidohydrolase
BIS30_15745	COG3069	C4-dicarboxylate transmembrane transporter activity
BIS30_15755	COG2329	Antibiotic biosynthesis monooxygenase
BIS30_15760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIS30_15765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BIS30_15780	COG1309	transcriptional regulator
BIS30_15785	COG1511	domain protein
BIS30_15790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIS30_15795	COG4377	Putative membrane peptidase family (DUF2324)
BIS30_15805	COG1363	Peptidase, m42
BIS30_15810	COG4405	Protein conserved in bacteria
BIS30_15815	COG1301	dicarboxylic acid transport
BIS30_15825	COG1234	tRNA 3'-trailer cleavage
BIS30_15830	COG0095	Lipoate-protein ligase
BIS30_15835	COG0702	epimerase
BIS30_15840	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_15850	COG0501	Belongs to the peptidase M48B family
BIS30_15860	COG0456	acetyltransferase
BIS30_15865	COG0604	alcohol dehydrogenase
BIS30_15870	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BIS30_15875	COG0406	alpha-ribazole phosphatase activity
BIS30_15880	COG0183	Belongs to the thiolase family
BIS30_15885	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_15890	COG1268	BioY protein
BIS30_15895	COG0840	transmembrane signaling receptor activity
BIS30_15900	COG0723	plastoquinol--plastocyanin reductase activity
BIS30_15900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIS30_15905	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_15915	COG4903	ComK protein
BIS30_15920	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_15930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BIS30_15945	COG0398	Pfam SNARE associated Golgi protein
BIS30_15950	COG0681	Belongs to the peptidase S26 family
BIS30_15955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BIS30_15960	COG1846	Transcriptional regulator
BIS30_15970	COG0738	Major facilitator superfamily
BIS30_15975	COG0673	inositol 2-dehydrogenase activity
BIS30_15980	COG0561	phosphatase activity
BIS30_15985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BIS30_15990	COG1609	Transcriptional regulator
BIS30_15995	COG3180	Ammonia monooxygenase
BIS30_16000	COG0477	Major facilitator Superfamily
BIS30_16000	COG2814	Major facilitator Superfamily
BIS30_16005	COG4533	DNA binding
BIS30_16015	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BIS30_16020	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BIS30_16025	COG1074	ATP-dependent DNA helicase activity
BIS30_16030	COG0420	3'-5' exonuclease activity
BIS30_16035	COG0419	ATPase involved in DNA repair
BIS30_16040	COG1403	HNH endonuclease
BIS30_16080	COG5337	Spore coat protein CotH
BIS30_16085	COG0179	Fumarylacetoacetate (FAA) hydrolase
BIS30_16095	COG1404	Belongs to the peptidase S8 family
BIS30_16105	COG0367	asparagine synthase
BIS30_16110	COG2318	DinB family
BIS30_16115	COG1562	ergosterol biosynthetic process
BIS30_16120	COG0534	Mate efflux family protein
BIS30_16125	COG1917	Cupin 2, conserved barrel domain protein
BIS30_16125	COG2207	Transcriptional regulator
BIS30_16130	COG1609	Transcriptional regulator
BIS30_16135	COG0673	inositol 2-dehydrogenase activity
BIS30_16140	COG2318	DinB family
BIS30_16145	COG1279	arginine transmembrane transporter activity
BIS30_16150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIS30_16155	COG1357	PFAM Pentapeptide repeats (8 copies)
BIS30_16160	COG2267	carboxylic ester hydrolase activity
BIS30_16165	COG0529	Catalyzes the synthesis of activated sulfate
BIS30_16170	COG2046	Belongs to the sulfate adenylyltransferase family
BIS30_16175	COG0175	sulfate reduction
BIS30_16180	COG2045	Belongs to the ComB family
BIS30_16185	COG1809	phosphosulfolactate synthase activity
BIS30_16190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_16195	COG4948	Mandelate Racemase Muconate Lactonizing
BIS30_16200	COG2814	Major facilitator Superfamily
BIS30_16205	COG0454	-acetyltransferase
BIS30_16210	COG2153	protein acetylation
BIS30_16215	COG0646	methionine synthase
BIS30_16215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BIS30_16220	COG1666	GTP binding
BIS30_16225	COG2996	Protein conserved in bacteria
BIS30_16235	COG1307	EDD domain protein, DegV family
BIS30_16240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BIS30_16260	COG0561	phosphatase activity
BIS30_16265	COG1073	alpha beta
BIS30_16270	COG2151	metal-sulfur cluster biosynthetic enzyme
BIS30_16280	COG0277	FAD linked oxidase domain protein
BIS30_16285	COG2271	Major facilitator Superfamily
BIS30_16290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BIS30_16305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BIS30_16310	COG0505	Belongs to the CarA family
BIS30_16315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BIS30_16320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BIS30_16335	COG2267	carboxylic ester hydrolase activity
BIS30_16345	COG1744	ABC transporter substrate-binding protein PnrA-like
BIS30_16365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIS30_16370	COG5504	Zn-dependent protease
BIS30_16375	COG0444	Belongs to the ABC transporter superfamily
BIS30_16380	COG4608	Belongs to the ABC transporter superfamily
BIS30_16390	COG0601	transmembrane transport
BIS30_16395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIS30_16405	COG0180	Tryptophanyl-tRNA synthetase
BIS30_16410	COG4166	transmembrane transport
BIS30_16415	COG0601	transmembrane transport
BIS30_16420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIS30_16425	COG0444	Belongs to the ABC transporter superfamily
BIS30_16430	COG4608	Belongs to the ABC transporter superfamily
BIS30_16435	COG2814	Major facilitator Superfamily
BIS30_16440	COG0456	acetyltransferase
BIS30_16445	COG1393	Belongs to the ArsC family
BIS30_16450	COG0861	Integral membrane protein TerC family
BIS30_16455	COG4862	establishment of competence for transformation
BIS30_16460	COG4469	Competence protein
BIS30_16465	COG1164	Oligoendopeptidase f
BIS30_16485	COG2346	COG2346, Truncated hemoglobins
BIS30_16490	COG0741	lytic transglycosylase activity
BIS30_16495	COG4116	CYTH
BIS30_16505	COG2357	RelA SpoT domain protein
BIS30_16510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BIS30_16515	COG0564	pseudouridine synthase activity
BIS30_16520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BIS30_16525	COG0569	domain protein
BIS30_16525	COG0475	glutathione-regulated potassium exporter activity
BIS30_16530	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BIS30_16540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIS30_16545	COG2104	thiamine diphosphate biosynthetic process
BIS30_16550	COG2022	thiamine diphosphate biosynthetic process
BIS30_16555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BIS30_16560	COG0351	phosphomethylpyrimidine kinase
BIS30_16565	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BIS30_16625	COG0210	DNA helicase
BIS30_16635	COG2153	protein acetylation
BIS30_16640	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BIS30_16645	COG2382	esterase
BIS30_16650	COG0626	cystathionine gamma-synthase activity
BIS30_16655	COG0626	cystathionine gamma-synthase activity
BIS30_16665	COG5505	Protein of unknown function (DUF819)
BIS30_16690	COG0457	Tetratricopeptide repeat
BIS30_16720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_16720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIS30_16720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIS30_16725	COG1482	cell wall glycoprotein biosynthetic process
BIS30_16745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIS30_16765	COG0109	protoheme IX farnesyltransferase activity
BIS30_16775	COG0726	polysaccharide deacetylase
BIS30_16795	COG5504	Zn-dependent protease
BIS30_16800	COG2205	protein histidine kinase activity
BIS30_16810	COG3383	formate dehydrogenase (NAD+) activity
BIS30_16815	COG2427	Protein of unknown function (DUF1641)
BIS30_16825	COG1051	belongs to the nudix hydrolase family
BIS30_16835	COG2124	cytochrome p450
BIS30_16840	COG1819	glycosyl
BIS30_16850	COG1587	Uroporphyrinogen-III synthase
BIS30_16855	COG0390	transport system, permease component
BIS30_16860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BIS30_16865	COG0697	spore germination
BIS30_16870	COG4297	protein containing double-stranded beta helix domain
BIS30_16880	COG1252	NADH dehydrogenase
BIS30_16885	COG1904	glucuronate isomerase
BIS30_16890	COG2211	Major facilitator Superfamily
BIS30_16895	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BIS30_16900	COG1063	alcohol dehydrogenase
BIS30_16905	COG1312	Catalyzes the dehydration of D-mannonate
BIS30_16910	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_16915	COG2271	Major facilitator Superfamily
BIS30_16920	COG1609	Transcriptional regulator
BIS30_16925	COG0246	Mannitol dehydrogenase
BIS30_16930	COG2721	sulfolactate sulfo-lyase activity
BIS30_16935	COG0730	response to heat
BIS30_16940	COG2318	DinB family
BIS30_16945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIS30_16950	COG0457	Tetratricopeptide repeat
BIS30_16960	COG2350	Protein conserved in bacteria
BIS30_16965	COG1388	LysM domain
BIS30_16965	COG5632	N-Acetylmuramoyl-L-alanine amidase
BIS30_16965	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_16975	COG4195	phage-related replication protein
BIS30_16980	COG3546	catalase activity
BIS30_16985	COG2856	Zn peptidase
BIS30_16990	COG1396	sequence-specific DNA binding
BIS30_17000	COG1522	sequence-specific DNA binding
BIS30_17005	COG1484	DNA-dependent DNA replication
BIS30_17030	COG1595	DNA-templated transcription, initiation
BIS30_17035	COG3728	DNA packaging
BIS30_17035	COG5484	DNA packaging
BIS30_17045	COG5518	Phage portal protein
BIS30_17050	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BIS30_17055	COG4653	Phage capsid family
BIS30_17105	COG3953	SLT domain
BIS30_17105	COG5412	phage tail tape measure protein
BIS30_17105	COG5412	phage tail tape measure protein
BIS30_17105	COG3953	SLT domain
BIS30_17105	COG5412	phage tail tape measure protein
BIS30_17105	COG3953	SLT domain
BIS30_17110	COG1652	LysM domain
BIS30_17115	COG4193	domain, Protein
BIS30_17125	COG3628	GPW Gp25 family protein
BIS30_17130	COG3299	homolog of phage Mu protein gp47
BIS30_17135	COG3778	Protein conserved in bacteria
BIS30_17175	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_17175	COG5632	N-Acetylmuramoyl-L-alanine amidase
BIS30_17190	COG0306	phosphate transporter
BIS30_17195	COG1392	Phosphate transport regulator
BIS30_17200	COG0531	amino acid
BIS30_17205	COG0346	lactoylglutathione lyase activity
BIS30_17215	COG0463	Glycosyl transferase, family 2
BIS30_17225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIS30_17230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BIS30_17235	COG2362	D-Aminopeptidase
BIS30_17240	COG0601	transmembrane transport
BIS30_17245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BIS30_17250	COG0444	Belongs to the ABC transporter superfamily
BIS30_17255	COG4166	transmembrane transport
BIS30_17260	COG1619	proteins homologs of microcin C7 resistance protein MccF
BIS30_17265	COG4948	Mandelate Racemase Muconate Lactonizing
BIS30_17270	COG0791	NLP P60 protein
BIS30_17275	COG4608	Belongs to the ABC transporter superfamily
BIS30_17280	COG2706	6-phosphogluconolactonase activity
BIS30_17285	COG1834	amidinotransferase
BIS30_17290	COG1607	acyl-coa hydrolase
BIS30_17295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BIS30_17295	COG1017	nitric oxide dioxygenase activity
BIS30_17305	COG2323	membrane
BIS30_17310	COG2318	DinB family
BIS30_17315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_17320	COG2076	Multidrug Resistance protein
BIS30_17325	COG2076	Multidrug Resistance protein
BIS30_17330	COG0788	formyltetrahydrofolate deformylase activity
BIS30_17335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BIS30_17340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BIS30_17345	COG1764	response to oxidative stress
BIS30_17350	COG1846	Transcriptional regulator
BIS30_17355	COG1764	response to oxidative stress
BIS30_17360	COG0463	Glycosyl transferase, family 2
BIS30_17360	COG0457	Tetratricopeptide repeat
BIS30_17365	COG0590	tRNA wobble adenosine to inosine editing
BIS30_17375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIS30_17380	COG1404	Belongs to the peptidase S8 family
BIS30_17385	COG1366	Belongs to the anti-sigma-factor antagonist family
BIS30_17390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BIS30_17395	COG1122	ATPase activity
BIS30_17400	COG4721	ABC-type cobalt transport system, permease component
BIS30_17410	COG0745	RESPONSE REGULATOR receiver
BIS30_17415	COG5002	protein histidine kinase activity
BIS30_17415	COG3850	Histidine kinase
BIS30_17420	COG3212	peptidase
BIS30_17425	COG3212	peptidase
BIS30_17440	COG2239	Acts as a magnesium transporter
BIS30_17445	COG0789	Transcriptional regulator
BIS30_17460	COG1846	Transcriptional regulator
BIS30_17465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIS30_17470	COG0726	polysaccharide deacetylase
BIS30_17475	COG1408	metallophosphoesterase
BIS30_17485	COG0463	Glycosyl transferase, family 2
BIS30_17490	COG3285	dna ligase
BIS30_17490	COG1793	dna ligase
BIS30_17495	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BIS30_17500	COG5001	Diguanylate cyclase
BIS30_17500	COG3300	MHYT domain
BIS30_17505	COG0586	Pfam SNARE associated Golgi protein
BIS30_17510	COG0861	Integral membrane protein TerC family
BIS30_17515	COG1191	sigma factor activity
BIS30_17535	COG0501	Belongs to the peptidase M48B family
BIS30_17540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BIS30_17555	COG3594	Acyltransferase
BIS30_17560	COG5002	protein histidine kinase activity
BIS30_17565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BIS30_17575	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BIS30_17580	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BIS30_17585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BIS30_17590	COG0436	Aminotransferase
BIS30_17595	COG1850	ribulose-bisphosphate carboxylase activity
BIS30_17600	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BIS30_17605	COG0235	Class ii aldolase
BIS30_17610	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BIS30_17615	COG3339	Conserved Protein
BIS30_17630	COG3852	Histidine kinase
BIS30_17635	COG1846	Transcriptional regulator
BIS30_17640	COG1360	Flagellar Motor Protein
BIS30_17645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BIS30_17650	COG0542	response to heat
BIS30_17655	COG3949	Membrane
BIS30_17660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BIS30_17665	COG0720	synthase
BIS30_17670	COG0602	queuosine metabolic process
BIS30_17675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BIS30_17690	COG4873	Protein conserved in bacteria
BIS30_17705	COG3773	Cell wall hydrolase
BIS30_17710	COG2244	polysaccharide biosynthetic process
BIS30_17715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_17720	COG2217	Heavy metal translocating P-type atpase
BIS30_17730	COG0006	proline dipeptidase activity
BIS30_17740	COG1609	Transcriptional regulator
BIS30_17745	COG3711	transcriptional antiterminator
BIS30_17750	COG1263	PTS System
BIS30_17750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BIS30_17750	COG2190	(PTS) system
BIS30_17755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_17760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BIS30_17770	COG1533	DNA photolyase activity
BIS30_17775	COG0456	acetyltransferase
BIS30_17780	COG0840	transmembrane signaling receptor activity
BIS30_17785	COG2084	Dehydrogenase
BIS30_17790	COG2340	Cysteine-rich secretory protein family
BIS30_17795	COG0768	penicillin binding
BIS30_17800	COG4191	Histidine kinase
BIS30_17805	COG0436	Aminotransferase
BIS30_17815	COG0835	chemotaxis
BIS30_17815	COG0784	Response regulator, receiver
BIS30_17825	COG2814	Major facilitator Superfamily
BIS30_17830	COG1376	ErfK ybiS ycfS ynhG family protein
BIS30_17835	COG1408	metallophosphoesterase
BIS30_17840	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_17845	COG2200	EAL domain
BIS30_17850	COG4703	Protein of unknown function (DUF1797)
BIS30_17855	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BIS30_17865	COG0517	IMP dehydrogenase activity
BIS30_17870	COG0583	DNA-binding transcription factor activity
BIS30_17875	COG0716	FMN binding
BIS30_17885	COG0716	FMN binding
BIS30_17890	COG2171	N-acyltransferase activity
BIS30_17895	COG1473	amidohydrolase
BIS30_17905	COG0668	transmembrane transport
BIS30_17910	COG0450	alkyl hydroperoxide reductase
BIS30_17915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_17930	COG0746	molybdenum cofactor guanylyltransferase activity
BIS30_17935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BIS30_17940	COG0303	'Molybdopterin
BIS30_17945	COG1763	Mo-molybdopterin cofactor biosynthetic process
BIS30_17950	COG0314	molybdopterin synthase activity
BIS30_17955	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BIS30_17960	COG1132	(ABC) transporter
BIS30_17965	COG1132	(ABC) transporter
BIS30_17975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIS30_17980	COG1136	(ABC) transporter
BIS30_17985	COG0577	efflux transmembrane transporter activity
BIS30_17990	COG1349	DNA-binding transcription factor activity
BIS30_17995	COG1105	Belongs to the carbohydrate kinase PfkB family
BIS30_18000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIS30_18000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BIS30_18000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIS30_18005	COG2801	Transposase and inactivated derivatives
BIS30_18015	COG0681	Belongs to the peptidase S26 family
BIS30_18025	COG0488	(ABC) transporter
BIS30_18030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIS30_18035	COG2309	aminopeptidase activity
BIS30_18045	COG1077	Cell shape determining protein MreB Mrl
BIS30_18050	COG2002	toxin-antitoxin pair type II binding
BIS30_18055	COG3852	Histidine kinase
BIS30_18060	COG2105	PFAM AIG2 family protein
BIS30_18060	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BIS30_18065	COG0569	domain protein
BIS30_18070	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BIS30_18075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIS30_18085	COG0561	phosphatase activity
BIS30_18090	COG0242	peptide deformylase activity
BIS30_18100	COG0497	DNA recombination
BIS30_18105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BIS30_18110	COG0022	dehydrogenase e1 component
BIS30_18115	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIS30_18120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIS30_18125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_18135	COG2801	Transposase and inactivated derivatives
BIS30_18140	COG1982	Orn Lys Arg decarboxylase major
BIS30_18145	COG4476	Belongs to the UPF0223 family
BIS30_18150	COG4493	Belongs to the UPF0637 family
BIS30_18160	COG0483	inositol monophosphate 1-phosphatase activity
BIS30_18170	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BIS30_18190	COG1595	DNA-templated transcription, initiation
BIS30_18220	COG4896	Protein conserved in bacteria
BIS30_18230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BIS30_18235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BIS30_18240	COG2066	Belongs to the glutaminase family
BIS30_18245	COG4838	Belongs to the UPF0358 family
BIS30_18250	COG0772	Belongs to the SEDS family
BIS30_18255	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BIS30_18260	COG1612	heme a metabolic process
BIS30_18265	COG0109	protoheme IX farnesyltransferase activity
BIS30_18270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BIS30_18270	COG2010	Cytochrome c
BIS30_18275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BIS30_18280	COG1845	cytochrome c oxidase, subunit III
BIS30_18285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BIS30_18290	COG3336	cytochrome c oxidase
BIS30_18300	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BIS30_18305	COG2340	Cysteine-rich secretory protein family
BIS30_18320	COG3679	Belongs to the UPF0342 family
BIS30_18325	COG4471	UPF0298 protein
BIS30_18330	COG0742	ribosomal rna small subunit methyltransferase
BIS30_18335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BIS30_18340	COG3314	Sporulation integral membrane protein YlbJ
BIS30_18345	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIS30_18350	COG3480	Lon protease (S16) C-terminal proteolytic domain
BIS30_18355	COG1323	Belongs to the UPF0348 family
BIS30_18360	COG1399	metal-binding, possibly nucleic acid-binding protein
BIS30_18365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BIS30_18375	COG0454	-acetyltransferase
BIS30_18380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIS30_18385	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BIS30_18390	COG2001	Belongs to the MraZ family
BIS30_18395	COG0275	rRNA processing
BIS30_18400	COG4839	cell division protein FtsL
BIS30_18415	COG0768	penicillin binding
BIS30_18425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BIS30_18435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BIS30_18440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BIS30_18445	COG0772	Belongs to the SEDS family
BIS30_18450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIS30_18455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BIS30_18460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BIS30_18465	COG3879	Bacterial protein of unknown function (DUF881)
BIS30_18470	COG3879	Bacterial protein of unknown function (DUF881)
BIS30_18475	COG3856	small basic protein
BIS30_18480	COG0849	cell division
BIS30_18485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BIS30_18490	COG4412	M6 family metalloprotease domain protein
BIS30_18490	COG1404	Belongs to the peptidase S8 family
BIS30_18500	COG1191	sigma factor activity
BIS30_18505	COG1191	sigma factor activity
BIS30_18510	COG1119	ATPase activity
BIS30_18515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIS30_18520	COG1873	PFAM PRC-barrel domain
BIS30_18530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BIS30_18535	COG1799	cell septum assembly
BIS30_18540	COG0762	integral membrane protein
BIS30_18545	COG2302	S4 RNA-binding domain
BIS30_18550	COG3599	regulation of cell shape
BIS30_18555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BIS30_18560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BIS30_18565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BIS30_18570	COG0564	pseudouridine synthase activity
BIS30_18575	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BIS30_18580	COG2233	PERMEase
BIS30_18585	COG0540	Belongs to the ATCase OTCase family
BIS30_18590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BIS30_18595	COG0505	Belongs to the CarA family
BIS30_18600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BIS30_18605	COG0543	2 iron, 2 sulfur cluster binding
BIS30_18610	COG0167	dihydroorotate dehydrogenase activity
BIS30_18615	COG0284	orotidine-5'-phosphate decarboxylase activity
BIS30_18620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BIS30_18630	COG0175	sulfate reduction
BIS30_18635	COG0306	phosphate transporter
BIS30_18640	COG2046	Belongs to the sulfate adenylyltransferase family
BIS30_18645	COG0529	Catalyzes the synthesis of activated sulfate
BIS30_18650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BIS30_18655	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BIS30_18660	COG1648	precorrin-2 dehydrogenase activity
BIS30_18670	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BIS30_18675	COG1561	YicC-like family, N-terminal region
BIS30_18680	COG2052	Domain of unknown function (DUF370)
BIS30_18685	COG0194	GDP metabolic process
BIS30_18690	COG1758	RNA polymerase activity
BIS30_18695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BIS30_18700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BIS30_18705	COG0242	peptide deformylase activity
BIS30_18710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BIS30_18715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIS30_18715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BIS30_18720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BIS30_18725	COG0631	protein serine/threonine phosphatase activity
BIS30_18730	COG0515	serine threonine protein kinase
BIS30_18730	COG2815	serine threonine protein kinase
BIS30_18735	COG1162	GTPase activity
BIS30_18740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BIS30_18745	COG1564	THIamine pyrophosphokinase
BIS30_18755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BIS30_18760	COG1302	Protein conserved in bacteria
BIS30_18765	COG1461	Dihydroxyacetone kinase
BIS30_18770	COG1760	l-serine dehydratase
BIS30_18775	COG1760	l-serine dehydratase
BIS30_18780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BIS30_18785	COG2050	protein possibly involved in aromatic compounds catabolism
BIS30_18785	COG1349	DNA-binding transcription factor activity
BIS30_18790	COG0416	fatty acid biosynthetic process
BIS30_18795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BIS30_18800	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_18805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIS30_18810	COG0571	ribonuclease III activity
BIS30_18815	COG1196	nuclear chromosome segregation
BIS30_18820	COG0552	protein localization to endoplasmic reticulum
BIS30_18830	COG2801	Transposase and inactivated derivatives
BIS30_18840	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BIS30_18845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BIS30_18850	COG0228	four-way junction DNA binding
BIS30_18855	COG1837	Belongs to the UPF0109 family
BIS30_18865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BIS30_18870	COG0336	Belongs to the RNA methyltransferase TrmD family
BIS30_18875	COG0335	large ribosomal subunit rRNA binding
BIS30_18885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BIS30_18895	COG2257	FlhB HrpN YscU SpaS Family
BIS30_18900	COG0045	succinate-CoA ligase (ADP-forming) activity
BIS30_18905	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BIS30_18910	COG0758	DNA mediated transformation
BIS30_18915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIS30_18920	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BIS30_18925	COG4974	Belongs to the 'phage' integrase family
BIS30_18930	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BIS30_18940	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BIS30_18945	COG1815	bacterial-type flagellum-dependent cell motility
BIS30_18950	COG1558	bacterial-type flagellum-dependent cell motility
BIS30_18955	COG1677	Flagellar hook-basal body complex protein FliE
BIS30_18960	COG1766	The M ring may be actively involved in energy transduction
BIS30_18965	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIS30_18970	COG1317	bacterial-type flagellum organization
BIS30_18975	COG1157	protein secretion by the type III secretion system
BIS30_18980	COG2882	bacterial-type flagellum organization
BIS30_18985	COG3334	PFAM MgtE intracellular
BIS30_18990	COG3144	bacterial-type flagellum assembly
BIS30_18995	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BIS30_19000	COG4786	Flagellar basal body rod
BIS30_19005	COG1582	Flagellar protein (FlbD)
BIS30_19010	COG1580	Controls the rotational direction of flagella during chemotaxis
BIS30_19015	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIS30_19020	COG1776	CheC inhibitor of MCP methylation
BIS30_19020	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BIS30_19025	COG2201	protein-glutamate methylesterase activity
BIS30_19030	COG3190	flagellar
BIS30_19035	COG1338	Plays a role in the flagellum-specific transport system
BIS30_19045	COG1684	flagellar biosynthetic protein fliR
BIS30_19050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIS30_19055	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIS30_19060	COG1419	protein localization to endoplasmic reticulum
BIS30_19065	COG0455	bacterial-type flagellum organization
BIS30_19070	COG2201	protein-glutamate methylesterase activity
BIS30_19075	COG0643	Histidine kinase
BIS30_19075	COG2198	Histidine kinase
BIS30_19080	COG0835	chemotaxis
BIS30_19085	COG1776	CheC inhibitor of MCP methylation
BIS30_19090	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BIS30_19095	COG1191	sigma factor activity
BIS30_19110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BIS30_19115	COG0528	UMP kinase activity
BIS30_19120	COG0233	cytoplasmic translational termination
BIS30_19125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BIS30_19130	COG4589	Belongs to the CDS family
BIS30_19135	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BIS30_19140	COG0750	zinc metalloprotease
BIS30_19145	COG0442	prolyl-tRNA aminoacylation
BIS30_19150	COG2176	DNA-directed DNA polymerase activity
BIS30_19155	COG0779	Required for maturation of 30S ribosomal subunits
BIS30_19160	COG0195	Participates in both transcription termination and antitermination
BIS30_19165	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BIS30_19170	COG1358	cellular component organization or biogenesis
BIS30_19175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BIS30_19180	COG1550	Protein conserved in bacteria
BIS30_19185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BIS30_19190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BIS30_19195	COG0196	riboflavin kinase activity
BIS30_19200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BIS30_19205	COG1185	polyribonucleotide nucleotidyltransferase activity
BIS30_19210	COG0726	polysaccharide deacetylase
BIS30_19215	COG0612	Peptidase, M16
BIS30_19220	COG1873	PFAM PRC-barrel domain
BIS30_19225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIS30_19230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BIS30_19235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BIS30_19240	COG0527	aspartate kinase activity
BIS30_19245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BIS30_19250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BIS30_19255	COG0740	serine-type endopeptidase activity
BIS30_19265	COG4980	gas vesicle protein
BIS30_19265	COG1674	ftsk spoiiie
BIS30_19270	COG2188	Transcriptional regulator
BIS30_19275	COG2814	Major facilitator Superfamily
BIS30_19280	COG0612	Peptidase, M16
BIS30_19285	COG0612	Peptidase, M16
BIS30_19290	COG0300	oxidoreductase activity
BIS30_19305	COG1426	Protein conserved in bacteria
BIS30_19310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIS30_19315	COG1546	Belongs to the CinA family
BIS30_19315	COG1058	Belongs to the CinA family
BIS30_19320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BIS30_19325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIS30_19330	COG1418	mRNA catabolic process
BIS30_19335	COG1692	metallophosphoesterase
BIS30_19340	COG2359	stage V sporulation protein S
BIS30_19345	COG1063	alcohol dehydrogenase
BIS30_19350	COG0156	8-amino-7-oxononanoate synthase activity
BIS30_19355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BIS30_19360	COG4550	Control of competence regulator ComK, YlbF/YmcA
BIS30_19370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BIS30_19375	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BIS30_19400	COG3226	Transcriptional regulator
BIS30_19405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_19415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BIS30_19420	COG3321	synthase
BIS30_19425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BIS30_19425	COG2070	2-Nitropropane dioxygenase
BIS30_19430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIS30_19435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIS30_19440	COG3425	synthase
BIS30_19445	COG1024	Enoyl-CoA hydratase
BIS30_19450	COG1024	Enoyl-CoA hydratase
BIS30_19455	COG3321	synthase
BIS30_19455	COG0300	oxidoreductase activity
BIS30_19455	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_19455	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_19455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_19465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIS30_19465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BIS30_19465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIS30_19465	COG3321	synthase
BIS30_19465	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_19475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIS30_19475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BIS30_19475	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BIS30_19475	COG3321	synthase
BIS30_19480	COG2124	cytochrome p450
BIS30_19490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIS30_19495	COG1404	Belongs to the peptidase S8 family
BIS30_19505	COG4195	phage-related replication protein
BIS30_19510	COG1764	response to oxidative stress
BIS30_19520	COG2801	Transposase and inactivated derivatives
BIS30_19545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BIS30_19550	COG1923	regulation of RNA biosynthetic process
BIS30_19565	COG1780	Probably involved in ribonucleotide reductase function
BIS30_19570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIS30_19575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIS30_19580	COG4112	unkown
BIS30_19585	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIS30_19595	COG0464	growth
BIS30_19605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BIS30_19610	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BIS30_19615	COG0789	Transcriptional regulator
BIS30_19620	COG0174	glutamine synthetase
BIS30_19635	COG2211	Major facilitator Superfamily
BIS30_19640	COG3507	Belongs to the glycosyl hydrolase 43 family
BIS30_19655	COG1070	Carbohydrate kinase
BIS30_19670	COG2814	Major facilitator Superfamily
BIS30_19675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BIS30_19685	COG0756	dUTP diphosphatase activity
BIS30_19715	COG3832	glyoxalase III activity
BIS30_19735	COG0697	spore germination
BIS30_19760	COG4195	phage-related replication protein
BIS30_19770	COG0346	lactoylglutathione lyase activity
BIS30_19785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BIS30_19790	COG1388	LysM domain
BIS30_19795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BIS30_19800	COG4224	UPF0291 protein
BIS30_19805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BIS30_19815	COG3763	UPF0154 protein
BIS30_19825	COG0785	Cytochrome C biogenesis protein
BIS30_19830	COG2201	protein-glutamate methylesterase activity
BIS30_19835	COG4846	Membrane protein involved in cytochrome C biogenesis
BIS30_19845	COG0071	Belongs to the small heat shock protein (HSP20) family
BIS30_19860	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BIS30_19865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIS30_19885	COG0824	Thioesterase
BIS30_19895	COG4841	protein insertion into membrane
BIS30_19900	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BIS30_19905	COG1832	CoA-binding protein
BIS30_19910	COG0187	DNA topoisomerase II activity
BIS30_19935	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BIS30_19945	COG2246	polysaccharide biosynthetic process
BIS30_19950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIS30_19960	COG2404	hydrolase activity, acting on ester bonds
BIS30_19980	COG2404	hydrolase activity, acting on ester bonds
BIS30_19985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BIS30_19990	COG1024	Enoyl-CoA hydratase
BIS30_19995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BIS30_20000	COG0511	ligase activity, forming carbon-carbon bonds
BIS30_20005	COG0439	Biotin carboxylase
BIS30_20010	COG0318	PFAM AMP-dependent synthetase and ligase
BIS30_20015	COG1960	acyl-CoA dehydrogenase activity
BIS30_20030	COG1649	PFAM Uncharacterised BCR, COG1649
BIS30_20060	COG2027	D-alanyl-D-alanine carboxypeptidase
BIS30_20065	COG2017	converts alpha-aldose to the beta-anomer
BIS30_20070	COG0534	Mate efflux family protein
BIS30_20095	COG5632	N-Acetylmuramoyl-L-alanine amidase
BIS30_20095	COG1388	LysM domain
BIS30_20095	COG3409	Peptidoglycan-binding domain 1 protein
BIS30_20130	COG1705	Flagellar rod assembly protein muramidase FlgJ
BIS30_20130	COG3942	CHAP domain
BIS30_20245	COG0582	viral genome integration into host DNA
BIS30_20345	COG0582	viral genome integration into host DNA
BIS30_20350	COG0166	Belongs to the GPI family
BIS30_20355	COG0405	Gamma-glutamyltransferase
BIS30_20360	COG0583	DNA-binding transcription factor activity
BIS30_20370	COG0493	'glutamate synthase
BIS30_20375	COG0069	glutamate synthase activity
BIS30_20375	COG0070	glutamate synthase
BIS30_20375	COG0067	glutamate synthase
BIS30_20380	COG0583	DNA-binding transcription factor activity
BIS30_20385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BIS30_20405	COG0300	oxidoreductase activity
BIS30_20410	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BIS30_20420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_20445	COG2814	Major facilitator Superfamily
BIS30_20450	COG1070	Carbohydrate kinase
BIS30_20460	COG0243	molybdopterin cofactor binding
BIS30_20490	COG0840	transmembrane signaling receptor activity
BIS30_20490	COG5278	phosphoserine phosphatase activity
BIS30_20495	COG2368	4-hydroxyphenylacetate
BIS30_20500	COG4305	rare lipoprotein A
BIS30_20505	COG3619	membrane
BIS30_20515	COG1028	Short-chain dehydrogenase reductase Sdr
BIS30_20530	COG2135	peptidase activity
BIS30_20570	COG2720	vancomycin resistance protein
BIS30_20580	COG3655	Transcriptional regulator
BIS30_20585	COG3739	integral membrane protein
BIS30_20590	COG0583	DNA-binding transcription factor activity
BIS30_20620	COG0693	protein deglycase activity
BIS30_20625	COG2367	Beta-lactamase
BIS30_20630	COG4282	regulation of fungal-type cell wall biogenesis
BIS30_20635	COG3397	chitin binding
BIS30_20640	COG2318	DinB family
BIS30_20645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIS30_20650	COG0457	Tetratricopeptide repeat
BIS30_20660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIS30_20665	COG1215	transferase activity, transferring glycosyl groups