locus-tag class description BL14DL4_00001 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL14DL4_00002 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL14DL4_00004 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL14DL4_00005 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL14DL4_00007 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL14DL4_00011 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BL14DL4_00013 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BL14DL4_00024 ENOG4108UV1 cellular component movement BL14DL4_00026 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BL14DL4_00031 ENOG4107EV6 Inherit from COG: YD repeat protein BL14DL4_00033 ENOG4106ANW SMI1_KNR4 BL14DL4_00042 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BL14DL4_00043 ENOG41067D4 cell wall surface anchor family protein BL14DL4_0009 ENOG4106ITI Glutaredoxin BL14DL4_00109 ENOG4107NTZ BL14DL4_00111 ENOG4106J6E BL14DL4_00120 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BL14DL4_00123 ENOG4107D0N BL14DL4_00133 ENOG4105C7H Helicase, RecD TraA family BL14DL4_00136 ENOG4105GJD protein, conserved in bacteria BL14DL4_00146 ENOG4108J9Q DNA ligase BL14DL4_00156 ENOG4106YR8 BL14DL4_00157 ENOG41088HM BL14DL4_00159 ENOG4106PTB DnaB-like helicase C terminal domain BL14DL4_00160 ENOG4106IVX BL14DL4_00162 ENOG4106J9J DNA polymerase BL14DL4_00164 ENOG4106J9J DNA polymerase BL14DL4_00182 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BL14DL4_00183 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL14DL4_00184 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL14DL4_00187 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL14DL4_00189 ENOG4106ITI Glutaredoxin BL14DL4_00191 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BL14DL4_00194 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BL14DL4_00204 ENOG4108UV1 cellular component movement BL14DL4_00206 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BL14DL4_00209 ENOG4106F1P AAA ATPase, central domain protein BL14DL4_00210 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BL14DL4_00211 ENOG4105CXI aluminum resistance protein BL14DL4_00212 ENOG4105KV4 Transcriptional regulator BL14DL4_00213 ENOG4105C5F glutamine synthetase BL14DL4_00219 ENOG4105K59 histidine triad (HIT) protein BL14DL4_00234 ENOG4108MK9 spermidine N(1)-acetyltransferase BL14DL4_00237 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BL14DL4_00242 ENOG41062JF Transcriptional regulator BL14DL4_00243 ENOG41090MY MarR family Transcriptional regulator BL14DL4_00244 ENOG4108TVJ Nitroreductase BL14DL4_00245 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BL14DL4_00246 ENOG4107XWI flavin reductase domain protein, FMN-binding BL14DL4_00247 ENOG4105CS1 NAD(P)H quinone oxidoreductase BL14DL4_00250 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BL14DL4_00251 ENOG4105WFK nuclease BL14DL4_00252 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BL14DL4_00254 ENOG4108SVB resolvase BL14DL4_00255 ENOG4105VPS UPF0291 protein BL14DL4_00256 ENOG4105CV1 Transketolase (EC 2.2.1.1) BL14DL4_00258 ENOG4105VXM UPF0154 protein BL14DL4_00260 ENOG4107QIV Cytochrome c biogenesis protein BL14DL4_00265 ENOG4108I0Z Aconitate hydratase BL14DL4_00266 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BL14DL4_00271 ENOG4105MI2 BL14DL4_00274 ENOG4105W8X HesB YadR YfhF-family protein BL14DL4_00275 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BL14DL4_00276 ENOG4105K4P CoA-binding domain protein BL14DL4_00277 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BL14DL4_00279 ENOG4105CMD Transcriptional regulator, GntR family BL14DL4_00282 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BL14DL4_00283 ENOG4107QNK )-transporter BL14DL4_00284 ENOG4105CHR reductase BL14DL4_00290 ENOG4105R3A Nitrate reductase BL14DL4_00291 ENOG4108IUE nitrate reductase beta subunit BL14DL4_00298 ENOG4107V6Q Cyclic nucleotide-binding domain BL14DL4_00301 ENOG4105IJJ transcriptional regulator, crp fnr family BL14DL4_00302 ENOG4105DSQ Nitric oxide reductase BL14DL4_00303 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BL14DL4_00304 ENOG4106U2H Protein of unknown function (DUF1360) BL14DL4_00305 ENOG4107QWR cellulase (EC 3.2.1.4) BL14DL4_00307 ENOG4108428 Inherit from COG: -acetyltransferase BL14DL4_00312 ENOG4107UWP Major facilitator superfamily MFS_1 BL14DL4_00313 ENOG4108M26 parallel beta-helix repeat protein BL14DL4_00315 ENOG4105DQ4 alcohol dehydrogenase BL14DL4_00316 ENOG4105VUF Transcriptional regulator BL14DL4_00321 ENOG41060WC Enoyl-CoA hydratase BL14DL4_00322 ENOG4105C26 Dehydrogenase BL14DL4_00323 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BL14DL4_00324 ENOG4105C1G acyl-Coa dehydrogenase BL14DL4_00325 ENOG4105DG6 mannose-6-phosphate isomerase BL14DL4_00326 ENOG4105DM4 PTS System BL14DL4_00333 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BL14DL4_00334 ENOG4105DMW Dehydrogenase reductase BL14DL4_00335 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BL14DL4_00337 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BL14DL4_00338 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter BL14DL4_00339 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BL14DL4_00340 ENOG4107KJX Transcriptional regulator BL14DL4_00341 ENOG4108UXE Protein tyrosine phosphatase BL14DL4_00342 ENOG4107R5R arsenical pump membrane protein BL14DL4_00343 ENOG41082YX Transcriptional regulator, arsr family BL14DL4_00344 ENOG4105CZ9 Domain of unknown function (DU1801) BL14DL4_00346 ENOG4105CSC Glucose uptake protein BL14DL4_00347 ENOG4105F32 YngK protein BL14DL4_00349 ENOG4105F1A Pyruvate formate-lyase BL14DL4_00351 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BL14DL4_00357 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BL14DL4_00358 ENOG4107QX3 carboxylase BL14DL4_00359 ENOG4105E39 Enoyl-CoA hydratase BL14DL4_00360 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BL14DL4_00361 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BL14DL4_00362 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BL14DL4_00363 ENOG4105CEY Amp-dependent synthetase and ligase BL14DL4_00364 ENOG4105C1G acyl-Coa dehydrogenase BL14DL4_00365 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BL14DL4_00366 ENOG4105KVH Transcriptional regulator BL14DL4_00367 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BL14DL4_00368 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BL14DL4_00371 ENOG4105H67 Protein of unknown function (DUF421) BL14DL4_00373 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BL14DL4_00374 ENOG41061P3 phosphosulfolactate synthase BL14DL4_00376 ENOG4105DIA mandelate racemase muconate lactonizing BL14DL4_00377 ENOG4107RCC Major Facilitator Superfamily BL14DL4_00381 ENOG4105BZ8 glutamate synthase BL14DL4_00382 ENOG4105CBC glutamate synthase BL14DL4_00383 ENOG4105C5Q Transcriptional regulator BL14DL4_00389 ENOG4105BZ1 (ABC) transporter BL14DL4_00392 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BL14DL4_00393 ENOG4105C0R drug resistance transporter emrb qaca subfamily BL14DL4_00394 ENOG4108J2R molybdopterin oxidoreductase BL14DL4_00397 ENOG4108Q8B Spore germination protein BL14DL4_00398 ENOG4108NHD germination protein BL14DL4_00399 ENOG4108Q8B Spore germination protein BL14DL4_00400 ENOG4108Q8B Spore germination protein BL14DL4_00403 ENOG4105C8Q Methyl-accepting chemotaxis BL14DL4_00404 ENOG4108Z7R Chaperone CsaA BL14DL4_00405 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BL14DL4_00407 ENOG4108RZE Tetr family transcriptional regulator BL14DL4_00409 ENOG4105T9C HD domain BL14DL4_00411 ENOG4105FVX BL14DL4_00415 ENOG4108W8B Beta-lactamase domain protein BL14DL4_00418 ENOG4105D29 Helix-turn-helix type 11 domain protein BL14DL4_00420 ENOG4105KTU Transcriptional regulator, arsr family BL14DL4_00423 ENOG4105CUB amino acid BL14DL4_00425 ENOG4105C5E polysaccharide biosynthesis protein BL14DL4_00428 ENOG4107T8Q Glycosyl transferase (Group 1 BL14DL4_00429 ENOG4108SJC Membrane BL14DL4_00432 ENOG4107RUZ Sss sodium solute transporter superfamily BL14DL4_00433 ENOG41069ER domain protein BL14DL4_00434 ENOG4105C9U ATP-dependent DNA helicase RecQ BL14DL4_00439 ENOG4105UNS Pfam:DUF419 BL14DL4_00442 ENOG4108IEG Formate dehydrogenase Alpha subunit BL14DL4_00452 ENOG4108NHD germination protein BL14DL4_00455 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BL14DL4_00458 ENOG4107S9D Alpha beta hydrolase BL14DL4_00462 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BL14DL4_00464 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BL14DL4_00465 ENOG4105ST3 Transcriptional regulator BL14DL4_00469 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BL14DL4_00470 ENOG4105SCY DNAK suppressor BL14DL4_00473 ENOG4105C26 Dehydrogenase BL14DL4_00477 ENOG4105EWU Squalene--hopene cyclase BL14DL4_00478 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BL14DL4_00480 ENOG4105C8J )-transporter BL14DL4_00481 ENOG4105C09 Bile acid BL14DL4_00482 ENOG4105C7S Dehydrogenase BL14DL4_00483 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BL14DL4_00484 ENOG4107T89 von Willebrand factor, type A BL14DL4_00485 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BL14DL4_00487 ENOG4105K4H Nlp p60 protein BL14DL4_00492 ENOG4105FR1 rard protein BL14DL4_00495 ENOG4108YQE rare lipoprotein a BL14DL4_00500 ENOG4105FBA Phospholipase Carboxylesterase BL14DL4_00502 ENOG4105E1V na solute symporter BL14DL4_00506 ENOG4108VXD carboxy-peptidase BL14DL4_00507 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BL14DL4_00508 ENOG4108PJD permease BL14DL4_00511 ENOG4106Z5R BL14DL4_00512 ENOG410841Q phosphoesterase PA-phosphatase related protein BL14DL4_00516 ENOG4105VSD UPF0346 protein BL14DL4_00518 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BL14DL4_00519 ENOG4108TSC N-acetyltransferase BL14DL4_00520 ENOG4107S4Y M20 DapE family protein YgeY BL14DL4_00523 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BL14DL4_00526 ENOG4105E0X reductase BL14DL4_00530 ENOG4105BZU Histidine kinase BL14DL4_00534 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BL14DL4_00535 ENOG41090WU lipolytic protein G-D-S-L family BL14DL4_00536 ENOG4108KF3 Electron transport protein SCO1 SenC BL14DL4_00539 ENOG4105C7B Threonine dehydratase BL14DL4_00541 ENOG4108UT2 hemolysin iii BL14DL4_00543 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BL14DL4_00546 ENOG4107YX5 Pfam:DUF548 BL14DL4_00548 ENOG4105C01 Dihydroxy-acid dehydratase BL14DL4_00551 ENOG4108V06 Glutathione peroxidase BL14DL4_00552 ENOG4105CKU formyltetrahydrofolate synthetase BL14DL4_00553 ENOG4105CVG Homoserine O-transsuccinylase BL14DL4_00554 ENOG4108QBV Monogalactosyldiacylglycerol synthase BL14DL4_00562 ENOG41081VK Ribonuclease BL14DL4_00567 ENOG410890F Dynamin family BL14DL4_00569 ENOG41065KQ synthase BL14DL4_00570 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BL14DL4_00571 ENOG4105C2W permease BL14DL4_00572 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BL14DL4_00573 ENOG4105CTD carboxy-peptidase BL14DL4_00574 ENOG4105DVT helicase BL14DL4_00577 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BL14DL4_00578 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BL14DL4_00579 ENOG4108UKS UPF0398 protein BL14DL4_00582 ENOG4107X2U Inherit from COG: Exonuclease-like protein BL14DL4_00583 ENOG4108I5C dEAD DEAH box helicase BL14DL4_00593 ENOG4105BZ4 penicillin-binding protein BL14DL4_00595 ENOG4105CSM endonuclease III BL14DL4_00598 ENOG4105CHM Aminotransferase BL14DL4_00600 ENOG4105YAC BL14DL4_00601 ENOG4105DVT helicase BL14DL4_00602 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BL14DL4_00603 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BL14DL4_00604 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BL14DL4_00606 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BL14DL4_00607 ENOG4105CPK Glycosyl transferase (Group 1 BL14DL4_00608 ENOG4105FJR Lmbe family BL14DL4_00609 ENOG4108Z5K methylglyoxal synthase BL14DL4_00610 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BL14DL4_00611 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BL14DL4_00612 ENOG4108JYZ YitT family BL14DL4_00616 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BL14DL4_00619 ENOG4108SXZ UPF0302 protein BL14DL4_00620 ENOG41068YB TPR repeat-containing protein BL14DL4_00623 ENOG4105CIH Imidazole acetol-phosphate transaminase BL14DL4_00624 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BL14DL4_00625 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BL14DL4_00627 ENOG4105DK0 Indole-3-glycerol phosphate synthase BL14DL4_00628 ENOG4108I0Q anthranilate phosphoribosyltransferase BL14DL4_00629 ENOG4105CRQ synthase (Component I) BL14DL4_00630 ENOG4105KHN chorismate mutase BL14DL4_00631 ENOG4105D49 3-dehydroquinate synthase BL14DL4_00632 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BL14DL4_00633 ENOG4105BZU Histidine kinase BL14DL4_00634 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BL14DL4_00635 ENOG4105EAH synthase BL14DL4_00636 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BL14DL4_00637 ENOG4105XXQ heptaprenyl diphosphate synthase component I BL14DL4_00639 ENOG4105EUJ GTP cyclohydrolase i BL14DL4_00640 ENOG4105K70 DNA-binding protein BL14DL4_00641 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BL14DL4_00644 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BL14DL4_00645 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BL14DL4_00646 ENOG41065D1 BL14DL4_00647 ENOG4105S2F BL14DL4_00650 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BL14DL4_00651 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BL14DL4_00652 ENOG4105CAT Cytidine monophosphate kinase BL14DL4_00654 ENOG4105MSI germination protein ypeb BL14DL4_00657 ENOG4105HDK L-asparaginase BL14DL4_00658 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BL14DL4_0066 ENOG41068G1 BL14DL4_00661 ENOG4107RGJ metallophosphoesterase BL14DL4_00664 ENOG4105I7S Abortive infection protein BL14DL4_00665 ENOG4105C9U ATP-dependent DNA helicase RecQ BL14DL4_00666 ENOG4105T7X BL14DL4_00668 ENOG4108SAX Membrane BL14DL4_00669 ENOG4108JQ1 Dehydrogenase BL14DL4_00670 ENOG4105DR5 peptidase BL14DL4_00676 ENOG4105US7 Histidine kinase BL14DL4_00677 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BL14DL4_00678 ENOG4105BZU Histidine kinase BL14DL4_00679 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BL14DL4_00680 ENOG4105CRE cytochrome C BL14DL4_00681 ENOG4107TWT Cytochrome c biogenesis protein BL14DL4_00682 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BL14DL4_00683 ENOG4105FE9 pseudouridine synthase BL14DL4_00685 ENOG4108JIC nucleoside recognition domain protein BL14DL4_00686 ENOG4105DZ1 carboxypeptidase BL14DL4_00688 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BL14DL4_00689 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BL14DL4_00693 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BL14DL4_00694 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BL14DL4_00695 ENOG4108R6K riboflavin synthase, subunit alpha BL14DL4_00696 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BL14DL4_00698 ENOG4105MEW serine threonine protein phosphatase BL14DL4_00699 ENOG4105MYT Heat shock protein BL14DL4_00702 ENOG4107ZE5 PPIases accelerate the folding of proteins BL14DL4_00703 ENOG4105PTM secreted protein BL14DL4_00704 ENOG4105K7W phage-related replication protein BL14DL4_00705 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BL14DL4_00708 ENOG4105G6R Stage v sporulation protein ae BL14DL4_00710 ENOG4105CZ3 stage V sporulation protein ad BL14DL4_00711 ENOG41090VF Stage v sporulation protein ac BL14DL4_00714 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BL14DL4_00715 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BL14DL4_00716 ENOG41082AN stage II sporulation protein BL14DL4_00717 ENOG4105DZ1 carboxypeptidase BL14DL4_00718 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BL14DL4_00719 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BL14DL4_00720 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BL14DL4_00722 ENOG4105I3K Ferric uptake regulator, Fur family BL14DL4_00723 ENOG4105MZ9 stage II sporulation protein m BL14DL4_00724 ENOG4105CK1 PTS System BL14DL4_00726 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BL14DL4_00727 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BL14DL4_00730 ENOG4107YB6 acetyltransferase, (GNAT) family BL14DL4_00732 ENOG4108YZ4 nudix hydrolase BL14DL4_00734 ENOG4105PF9 Transcriptional regulator BL14DL4_00736 ENOG4105CPC Aldo Keto reductase BL14DL4_00740 ENOG4106HZJ BL14DL4_00743 ENOG4105KAC Antibiotic biosynthesis monooxygenase BL14DL4_00744 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BL14DL4_00746 ENOG4107RRN ABC transporter substrate-binding protein BL14DL4_00747 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BL14DL4_00748 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BL14DL4_00749 ENOG4108RZA ABC transporter BL14DL4_00751 ENOG4107R73 Mate efflux family protein BL14DL4_00755 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BL14DL4_00757 ENOG4105E5W Transporter BL14DL4_00758 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BL14DL4_00761 ENOG4105DA5 (ABC) transporter BL14DL4_00765 ENOG4105K7W phage-related replication protein BL14DL4_00766 ENOG4108IXY short-chain dehydrogenase reductase BL14DL4_00767 ENOG41069FQ Metallo-beta-lactamase superfamily BL14DL4_00768 ENOG4105II7 pyrroline-5-carboxylate reductase BL14DL4_00770 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BL14DL4_00772 ENOG4105WDJ 50S ribosomal protein L33 BL14DL4_00773 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BL14DL4_00774 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BL14DL4_00778 ENOG4108TZY GntR Family Transcriptional Regulator BL14DL4_00779 ENOG4105CS2 ec 3.2.1.21 BL14DL4_00780 ENOG4105CK1 PTS System BL14DL4_00781 ENOG4105VCP PTS System BL14DL4_00782 ENOG4105VZJ PTS System BL14DL4_00783 ENOG4105G6Z alkaline phosphatase BL14DL4_00784 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BL14DL4_00785 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BL14DL4_00786 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BL14DL4_00788 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BL14DL4_00789 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BL14DL4_00790 ENOG4108HNZ carboxyl transferase BL14DL4_00791 ENOG4108QEG Membrane BL14DL4_00792 ENOG4105CDA abc transporter atp-binding protein BL14DL4_00793 ENOG4105E5Q amino acid AbC transporter BL14DL4_00794 ENOG4108HW3 (ABC) transporter BL14DL4_00796 ENOG4108Y6J UPF0403 protein BL14DL4_00797 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BL14DL4_00798 ENOG4105C7S Dehydrogenase BL14DL4_00799 ENOG4105CPP Dehydrogenase, E1 component BL14DL4_00802 ENOG4105CKM Branched-chain carboxylic acid kinase BL14DL4_00803 ENOG4107RDP Dehydrogenase BL14DL4_00805 ENOG4108JUB Transcriptional regulator BL14DL4_00806 ENOG4106CCJ Protein of unknown function (DUF2627) BL14DL4_00807 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BL14DL4_00808 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BL14DL4_00811 ENOG4105D7W serine acetyltransferase BL14DL4_00813 ENOG4107QQR Sporulation BL14DL4_00814 ENOG4105S1Z Stage IV sporulation protein B BL14DL4_00815 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BL14DL4_00816 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BL14DL4_00817 ENOG4105DX0 Hemolysin A BL14DL4_00818 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BL14DL4_00819 ENOG4105CTB Polyprenyl synthetase BL14DL4_00820 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BL14DL4_00821 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BL14DL4_00822 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BL14DL4_00823 ENOG4105M7K Involved in the transcription termination process (By similarity) BL14DL4_00824 ENOG4108ZSR alkaline shock protein BL14DL4_00825 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BL14DL4_00829 ENOG410644B Stage III sporulation protein af BL14DL4_00831 ENOG4105KQ4 Stage iii sporulation protein ad BL14DL4_00832 ENOG4108CQH stage III sporulation protein AC BL14DL4_00833 ENOG4105KR5 Stage iii sporulation protein BL14DL4_00834 ENOG4105CD2 stage iii sporulation protein aa BL14DL4_00836 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BL14DL4_00837 ENOG4105DC7 peptidase M24 BL14DL4_00838 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BL14DL4_00840 ENOG4105CBJ Metal-dependent enzyme BL14DL4_00843 ENOG4105KST dependent repressor BL14DL4_00844 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BL14DL4_00845 ENOG4105WZW rhodanese family BL14DL4_00847 ENOG4107SQ8 Glycine betaine BL14DL4_00848 ENOG4108IJ7 Glycine betaine BL14DL4_00849 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BL14DL4_00851 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BL14DL4_00852 ENOG4105C0D helicase BL14DL4_00857 ENOG4105VFR signal peptidase BL14DL4_00864 ENOG4106855 Competence protein BL14DL4_0087 ENOG4105K70 DNA-binding protein BL14DL4_00871 ENOG4105C5X domain protein BL14DL4_00878 ENOG4105E0M Sulfatase BL14DL4_00881 ENOG4107ZXI Rhomboid family BL14DL4_00883 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BL14DL4_00884 ENOG4105WDJ 50S ribosomal protein L33 BL14DL4_00888 ENOG41068DG YceG-like family BL14DL4_00889 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BL14DL4_00890 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BL14DL4_00891 ENOG4105E2Z phosphate ABC transporter (Permease BL14DL4_00892 ENOG4105C8U phosphate abc transporter BL14DL4_00893 ENOG4105CVA phosphate BL14DL4_00894 ENOG4107RF6 penicillin-binding protein BL14DL4_00896 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BL14DL4_00897 ENOG4105SXS Protein of unknown function (DUF456) BL14DL4_00900 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BL14DL4_00901 ENOG41063Y9 BL14DL4_00902 ENOG4108U5J '-nucleotidase BL14DL4_00903 ENOG4105N80 Ferric uptake regulator, Fur family BL14DL4_00904 ENOG4105FAV ABC, transporter BL14DL4_00905 ENOG4105FDK ABC transporter BL14DL4_00906 ENOG4108JYZ YitT family BL14DL4_00907 ENOG41069ZM Protein of unknown function (DUF2624) BL14DL4_00908 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BL14DL4_00911 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BL14DL4_00912 ENOG4105EGD dinuclear metal center protein, YbgI family BL14DL4_00926 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BL14DL4_00927 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BL14DL4_00929 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BL14DL4_00931 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BL14DL4_00932 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BL14DL4_00933 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) BL14DL4_00935 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BL14DL4_00936 ENOG4105KG3 cytidine deaminase BL14DL4_00937 ENOG4107YR5 Diacylglycerol kinase BL14DL4_00938 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BL14DL4_00939 ENOG4105CTJ Metal Dependent Phosphohydrolase BL14DL4_00940 ENOG4105C9A Phoh family BL14DL4_00941 ENOG4105EI1 sporulation protein yqfd BL14DL4_00942 ENOG41068P3 sporulation protein YqfC BL14DL4_00944 ENOG4105DI5 UPF0365 protein BL14DL4_00945 ENOG4105F7J membrane-bound serine protease BL14DL4_00946 ENOG4105KTH gatB Yqey BL14DL4_00947 ENOG4105VCC 30S ribosomal protein S21 BL14DL4_00949 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BL14DL4_00950 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BL14DL4_00951 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BL14DL4_00952 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BL14DL4_00953 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BL14DL4_00954 ENOG4105CFG Acts as a chaperone (By similarity) BL14DL4_00955 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BL14DL4_00956 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BL14DL4_00958 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BL14DL4_00960 ENOG4108ZRV stage ii sporulation protein p BL14DL4_00963 ENOG4105TQK DNA polymerase iii, delta' subunit BL14DL4_00965 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BL14DL4_00966 ENOG4108UK2 deaminase BL14DL4_00967 ENOG4105KQC Competence protein BL14DL4_00969 ENOG4108D32 Methyltransferase BL14DL4_00971 ENOG4108WF2 Metal Dependent Phosphohydrolase BL14DL4_00972 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BL14DL4_00973 ENOG410812S Rna-binding protein BL14DL4_00974 ENOG4105E2X shikimate dehydrogenase BL14DL4_00975 ENOG4105CQW ribosome biogenesis GTPase YqeH BL14DL4_00976 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BL14DL4_00979 ENOG4105Z7P Acetyltransferase (GNAT) family BL14DL4_0098 ENOG4108NE4 BL14DL4_00980 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BL14DL4_00981 ENOG4108JB9 formate dehydrogenase BL14DL4_00984 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BL14DL4_00989 ENOG4108ZRV stage ii sporulation protein p BL14DL4_00992 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BL14DL4_01001 ENOG4105WH1 Two component transcriptional regulator luxr family BL14DL4_01002 ENOG4105BZU Histidine kinase BL14DL4_01003 ENOG4105XXY Thioredoxin BL14DL4_01004 ENOG41087NI Sulfite exporter TauE/SafE BL14DL4_01005 ENOG4105VFE sira family BL14DL4_01006 ENOG4107TPS domain protein BL14DL4_01007 ENOG4105VFE sira family BL14DL4_01008 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BL14DL4_01009 ENOG4105XTG Pfam:DUF156 BL14DL4_01010 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BL14DL4_01013 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BL14DL4_01015 ENOG41080HJ 6-phospho 3-hexuloisomerase BL14DL4_01016 ENOG4108VA3 3-hexulose-6-phosphate synthase BL14DL4_01017 ENOG4105KVH Transcriptional regulator BL14DL4_01018 ENOG4105ECK Fatty Acid Desaturase BL14DL4_01019 ENOG4108ZGX Histidine kinase BL14DL4_01020 ENOG4108S01 response regulator BL14DL4_01021 ENOG4105CAY ferredoxin--nadp reductase BL14DL4_01022 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BL14DL4_01023 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BL14DL4_01024 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BL14DL4_01026 ENOG4108JQ7 (ABC) transporter BL14DL4_01029 ENOG4108ZX5 transcriptional regulator BL14DL4_01030 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BL14DL4_01034 ENOG410635A Membrane BL14DL4_01036 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BL14DL4_01037 ENOG4108HKT sucrose-6-phosphate hydrolase BL14DL4_01038 ENOG4105F3R pts system mannose fructose sorbose family iid BL14DL4_01039 ENOG4105ETZ PTS System BL14DL4_01040 ENOG4108IQ3 PTS system BL14DL4_01041 ENOG4105YHU PTS system BL14DL4_01042 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BL14DL4_01044 ENOG4105WDR BL14DL4_01047 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BL14DL4_01048 ENOG4105CV8 reductase BL14DL4_01049 ENOG4105F27 Major Facilitator BL14DL4_01050 ENOG4105KVH Transcriptional regulator BL14DL4_01051 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) BL14DL4_01052 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BL14DL4_01054 ENOG4108V5C ABC transporter BL14DL4_01055 ENOG4107RSM transcriptional regulator BL14DL4_01056 ENOG4105D94 Major Facilitator Superfamily BL14DL4_01058 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BL14DL4_01059 ENOG41082JN Transcriptional regulator BL14DL4_01060 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BL14DL4_01065 ENOG4105C28 cystathionine BL14DL4_01067 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BL14DL4_01068 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BL14DL4_01071 ENOG4107XRG penicillin-binding protein BL14DL4_01072 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BL14DL4_01074 ENOG4105CFP Peptidase U32 BL14DL4_01075 ENOG4105XYU peptidase (U32 family) BL14DL4_01076 ENOG4108VQJ O-methyltransferase BL14DL4_01077 ENOG4105HHA aminodeoxychorismate lyase BL14DL4_01078 ENOG4105VPH UPF0473 protein BL14DL4_01079 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BL14DL4_01080 ENOG4105VBH UPF0297 protein BL14DL4_01081 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BL14DL4_01082 ENOG4105C02 permease BL14DL4_01083 ENOG41060CR BL14DL4_01085 ENOG4105C7H Helicase, RecD TraA family BL14DL4_01087 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BL14DL4_01088 ENOG4105C3J Cysteine desulfurase BL14DL4_01090 ENOG4105D1H recombination factor protein RarA BL14DL4_01091 ENOG4105CUZ uba thif-type nad fad binding protein BL14DL4_01092 ENOG4105C9M aspartyl-trna synthetase BL14DL4_01093 ENOG4105CUT histidyl-tRNA synthetase BL14DL4_01095 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BL14DL4_01096 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BL14DL4_01097 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BL14DL4_01098 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BL14DL4_01099 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BL14DL4_01100 ENOG41067VP Protein of unknown function (DUF1049) BL14DL4_01101 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BL14DL4_01103 ENOG4105CKP Polysaccharide Biosynthesis Protein BL14DL4_01104 ENOG4108QG2 Membrane BL14DL4_01105 ENOG4105NAP BL14DL4_01106 ENOG4105VIE preprotein translocase, subunit YajC BL14DL4_01107 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BL14DL4_01108 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BL14DL4_01109 ENOG41061AI Protein of unknown function (DUF2905) BL14DL4_01110 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BL14DL4_01111 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BL14DL4_01115 ENOG41069DP small acid-soluble spore protein BL14DL4_01117 ENOG4105K7W phage-related replication protein BL14DL4_01120 ENOG4105CDY transcriptional regulatory protein BL14DL4_01122 ENOG4106678 morphogenetic protein associated with SpoVID BL14DL4_01123 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BL14DL4_01124 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BL14DL4_01125 ENOG4108IYU L-aspartate oxidase BL14DL4_01128 ENOG4105CQC Prephenate dehydratase BL14DL4_01129 ENOG41090I5 UPF0735 ACT domain-containing protein BL14DL4_01130 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BL14DL4_01132 ENOG4105K46 50S ribosomal protein l27 BL14DL4_01133 ENOG4105X36 (ribosomal) protein BL14DL4_01134 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BL14DL4_01138 ENOG41082BM Transcriptional regulator, arsr family BL14DL4_01139 ENOG4107QMS site-determining protein BL14DL4_01140 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BL14DL4_01141 ENOG4105YHC Rod shape-determining protein MreD BL14DL4_01142 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BL14DL4_01143 ENOG4105DFF Rod shape-determining protein mreb BL14DL4_01144 ENOG4105W5Q DNA repair protein (RadC BL14DL4_01145 ENOG4108Z03 MAF-like protein BL14DL4_01147 ENOG4106A3R peptidase BL14DL4_01148 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BL14DL4_01149 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BL14DL4_01151 ENOG4106AR7 Spore coat protein BL14DL4_01152 ENOG41068KH stage VI sporulation protein D BL14DL4_01153 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BL14DL4_01154 ENOG4105D52 delta-aminolevulinic acid dehydratase BL14DL4_01156 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BL14DL4_01158 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BL14DL4_01160 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BL14DL4_01161 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BL14DL4_01162 ENOG4108IUQ atp-dependent protease BL14DL4_01163 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BL14DL4_01164 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BL14DL4_01166 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BL14DL4_01167 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BL14DL4_01168 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BL14DL4_01169 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BL14DL4_01170 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BL14DL4_01171 ENOG4108ZP8 Acetolactate synthase small subunit BL14DL4_01172 ENOG4105C7K acetolactate synthase BL14DL4_01173 ENOG4105CM2 brancheD-chain amino acid aminotransferase BL14DL4_01175 ENOG4107R37 Glutamate dehydrogenase BL14DL4_01178 ENOG4108MDF Phage Portal Protein BL14DL4_01179 ENOG4105IG6 Phage terminase, large subunit BL14DL4_01187 ENOG4107EV6 Inherit from COG: YD repeat protein BL14DL4_01193 ENOG4105M59 Phosphodiesterase, mj0936 family BL14DL4_01194 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BL14DL4_01195 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BL14DL4_01196 ENOG4108XJQ germination protein BL14DL4_01197 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BL14DL4_01198 ENOG41067TZ transcriptional regulator, MarR family BL14DL4_01199 ENOG4105PFC Transcriptional regulator BL14DL4_01200 ENOG4105EMU Dehydrogenase BL14DL4_01202 ENOG4105E33 succinate dehydrogenase BL14DL4_01204 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BL14DL4_01206 ENOG4105CFH Aspartokinase BL14DL4_01207 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BL14DL4_01208 ENOG4105K63 Thioredoxin BL14DL4_01209 ENOG4105C10 Electron transfer flavoprotein BL14DL4_01210 ENOG4105BZJ Electron transfer flavoprotein BL14DL4_01211 ENOG41060WC Enoyl-CoA hydratase BL14DL4_01212 ENOG4107Z3H Transcriptional regulator, TetR family BL14DL4_01213 ENOG4105CEY Amp-dependent synthetase and ligase BL14DL4_01215 ENOG4105C98 muts2 protein BL14DL4_01216 ENOG4105DCG PHP domain protein BL14DL4_01218 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BL14DL4_01219 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BL14DL4_01223 ENOG4108IUZ ABC transporter BL14DL4_01226 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BL14DL4_01227 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BL14DL4_01228 ENOG4108RWN rrna methyltransferase BL14DL4_01229 ENOG41067MF small acid-soluble spore protein BL14DL4_01233 ENOG4105DRS transport system, permease BL14DL4_01236 ENOG4108MDK Dehydrogenase BL14DL4_01237 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BL14DL4_01238 ENOG4105EF1 ribulokinase BL14DL4_01239 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BL14DL4_01240 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase BL14DL4_01241 ENOG4105CN9 Peptidase m42 family protein BL14DL4_01243 ENOG410696E Membrane BL14DL4_01244 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BL14DL4_01245 ENOG4105VJV 50s ribosomal protein L35 BL14DL4_01246 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BL14DL4_01247 ENOG41067MG lrgb family BL14DL4_01249 ENOG4105DGI Alkaline phosphatase BL14DL4_01250 ENOG4105DY9 regulatoR BL14DL4_01251 ENOG4108HRK Histidine kinase BL14DL4_01253 ENOG4105U0R haloacid dehalogenase-like hydrolase BL14DL4_01254 ENOG4105C22 threonyL-tRNA synthetase BL14DL4_01255 ENOG4108TDW sporulation protein YtxC BL14DL4_01259 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BL14DL4_01261 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BL14DL4_01262 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BL14DL4_01263 ENOG4108NR7 pectate lyase BL14DL4_01264 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BL14DL4_01266 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BL14DL4_01267 ENOG4105C2M dna polymerase I BL14DL4_01268 ENOG4105BZU Histidine kinase BL14DL4_01269 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BL14DL4_01270 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BL14DL4_01271 ENOG4108HMX isocitrate dehydrogenase (NADP) BL14DL4_01272 ENOG4105BZN citrate synthase BL14DL4_01273 ENOG4108VMM UPF0756 membrane protein BL14DL4_01274 ENOG4108REF Sporulation integral membrane protein ytvi BL14DL4_01275 ENOG4105FS0 cytoplasmic membrane protein BL14DL4_01276 ENOG4105CA9 Pyruvate kinase BL14DL4_01277 ENOG4105CTQ phosphohexokinase BL14DL4_01278 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BL14DL4_01280 ENOG4105C6K Malic enzyme BL14DL4_01281 ENOG4105C0B DNA polymerase III (alpha subunit) BL14DL4_01282 ENOG4105VV2 BL14DL4_01284 ENOG4106EVM BL14DL4_01285 ENOG4105SFS phosphoesterase RecJ domain protein BL14DL4_01288 ENOG4105U3E Transcriptional regulator BL14DL4_01289 ENOG4105E8R UPF0173 metal-dependent hydrolase BL14DL4_01292 ENOG4105CH7 arginosuccinase BL14DL4_01293 ENOG4105CDH Citrulline--aspartate ligase BL14DL4_01294 ENOG4105EPU Molybdenum cofactor synthesis domain protein BL14DL4_01295 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BL14DL4_01297 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BL14DL4_01298 ENOG4105KBJ sporulation protein ytfj BL14DL4_01300 ENOG4105VK3 rdd domain containing protein BL14DL4_01301 ENOG4105D07 Signal peptide peptidase, SppA BL14DL4_01303 ENOG4105CW7 secretion protein, HlyD family BL14DL4_01306 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BL14DL4_01308 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BL14DL4_01313 ENOG4105U5Y Transcriptional regulator BL14DL4_01315 ENOG4105BZU Histidine kinase BL14DL4_01316 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BL14DL4_01319 ENOG4105KAF membrAne BL14DL4_01320 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BL14DL4_01323 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BL14DL4_01325 ENOG4105F1V Acetoin utilization protein BL14DL4_01326 ENOG4105W87 Cbs domain BL14DL4_01327 ENOG4105DGU Histone deacetylase BL14DL4_01328 ENOG4105ER2 Ompa motb domain protein BL14DL4_01329 ENOG4107R0U MotA TolQ exbB proton channel BL14DL4_01330 ENOG4105ETE Transcriptional regulator (LacI family BL14DL4_01331 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BL14DL4_01337 ENOG4105DFU Cell wall formation (By similarity) BL14DL4_01339 ENOG4108VDD TRNA binding domain protein BL14DL4_01342 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BL14DL4_01345 ENOG4105C6K Malic enzyme BL14DL4_01346 ENOG4105C8F Beta-lactamase domain protein BL14DL4_01347 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BL14DL4_01349 ENOG4108V15 phosphotransferase enzyme family BL14DL4_01350 ENOG4108IUM Glycogen debranching enzyme BL14DL4_01353 ENOG4107F58 2'-5' rna ligase BL14DL4_01354 ENOG4105C6T cysteine synthase BL14DL4_01356 ENOG4107QSE Dipeptidase BL14DL4_01357 ENOG4105C7N Xanthine uracil vitamin C permease BL14DL4_01358 ENOG4105YW5 deoR family transcriptional regulator BL14DL4_01361 ENOG4105CBX hi0933 family BL14DL4_01362 ENOG4105C94 Transporter BL14DL4_01364 ENOG41085GJ domain protein BL14DL4_01368 ENOG4105MU9 integral membrane protein BL14DL4_01369 ENOG4105DDC Oxidoreductase domain protein BL14DL4_01371 ENOG4105F5H Glycosyl Hydrolase Family 88 BL14DL4_01373 ENOG41075H3 AraC family transcriptional regulator BL14DL4_01375 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BL14DL4_01377 ENOG4105NTD Inherit from COG: Hydrolase BL14DL4_01379 ENOG4107V2S Transcriptional regulator BL14DL4_01380 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BL14DL4_01381 ENOG4105C8T Leucyl-tRNA synthetase BL14DL4_01383 ENOG410605W Major Facilitator BL14DL4_01384 ENOG4105D01 (LipO)protein BL14DL4_01385 ENOG4106UBQ BL14DL4_01386 ENOG4107R34 abc transporter permease protein BL14DL4_01387 ENOG4105C19 ABC transporter BL14DL4_01389 ENOG4105DVE abc transporter atp-binding protein BL14DL4_01390 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BL14DL4_01393 ENOG4105N5T Radical SAM Protein BL14DL4_01397 ENOG4105E8V Alpha Beta Hydrolase Fold protein BL14DL4_01398 ENOG4108Z0R Transferase BL14DL4_01399 ENOG4105YVM Phosphoesterase, PA-phosphatase related BL14DL4_01400 ENOG4105BZF Glycosyl transferase (Group 1 BL14DL4_01401 ENOG4105CAQ asparagine synthetase BL14DL4_01402 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BL14DL4_01407 ENOG4105D2X ABC transporter substrate-binding protein BL14DL4_01409 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BL14DL4_01413 ENOG4108RMU ferritin dps family protein BL14DL4_01416 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BL14DL4_01417 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BL14DL4_01418 ENOG4108V2W Carbonate dehydratase BL14DL4_01419 ENOG4105CKI cobalamin synthesis protein BL14DL4_01420 ENOG4105DSE periplasmic solute binding protein BL14DL4_01426 ENOG4105DTQ mandelate racemase muconate lactonizing BL14DL4_01427 ENOG4105CEY Amp-dependent synthetase and ligase BL14DL4_01428 ENOG4108IPT Naphthoate synthase BL14DL4_01429 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BL14DL4_01430 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BL14DL4_01431 ENOG4105E4F Isochorismate synthase BL14DL4_01432 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BL14DL4_01435 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BL14DL4_01437 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BL14DL4_01438 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BL14DL4_01463 ENOG4105CMD Transcriptional regulator, GntR family BL14DL4_01464 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BL14DL4_01470 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BL14DL4_01472 ENOG4105CZN Potassium uptake protein BL14DL4_01474 ENOG4106DF1 BL14DL4_01475 ENOG4108VNY MOSC domain protein BL14DL4_01476 ENOG4108JB8 alcohol dehydrogenase BL14DL4_01477 ENOG4105C26 Dehydrogenase BL14DL4_01478 ENOG4105TRT Transcriptional regulator BL14DL4_01480 ENOG4105JQZ Methyltransferase BL14DL4_01481 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BL14DL4_01482 ENOG4105F0F Oxalate decarboxylase BL14DL4_01488 ENOG41065RQ ADP-ribosylation crystallin J1 BL14DL4_01495 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) BL14DL4_01501 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BL14DL4_01503 ENOG4105EE0 oxidoreductase BL14DL4_01504 ENOG4108Z0Z intracellular protease Pfpi family BL14DL4_01505 ENOG4105C8Q Methyl-accepting chemotaxis BL14DL4_01506 ENOG4105C8Q Methyl-accepting chemotaxis BL14DL4_01507 ENOG4105C8Q Methyl-accepting chemotaxis BL14DL4_01509 ENOG4105EA8 2-Nitropropane dioxygenase BL14DL4_01510 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BL14DL4_01515 ENOG4105C37 (CBS) domain BL14DL4_01518 ENOG4107PBV potassium channel BL14DL4_01519 ENOG4107PBV potassium channel BL14DL4_01521 ENOG410900G Protein of unknown function (DUF421) BL14DL4_01523 ENOG4105KNA -acetyltransferase BL14DL4_01536 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BL14DL4_01550 ENOG4105CAR Terminase, large subunit BL14DL4_01575 ENOG4107QYV phosphohexose isomerase BL14DL4_01576 ENOG4107QW4 alcohol dehydrogenase BL14DL4_01577 ENOG4105WG9 Conserved Protein BL14DL4_01579 ENOG4105CHM Aminotransferase BL14DL4_01580 ENOG4108ZB6 transcriptional regulator AsnC family BL14DL4_01581 ENOG4108MUZ hydrolase BL14DL4_01584 ENOG4105C87 Aminotransferase class I and II BL14DL4_01586 ENOG4105Y38 Kinase-associated protein B BL14DL4_01589 ENOG4105BZ4 penicillin-binding protein BL14DL4_01590 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BL14DL4_01593 ENOG4108MRH transcriptional regulatory protein BL14DL4_01594 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BL14DL4_01595 ENOG4107ZTW SNARE associated Golgi BL14DL4_01596 ENOG4105DJ4 phosphatidylserine decarboxylase BL14DL4_01599 ENOG4105D65 subunit l BL14DL4_01600 ENOG4105HC0 Na H antiporter BL14DL4_01601 ENOG4108ZE9 Monovalent cation H antiporter subunit C BL14DL4_01602 ENOG4108JPZ Monovalent cation H antiporter subunit D BL14DL4_01603 ENOG4105SC1 monovalent cation H antiporter subunit E BL14DL4_01605 ENOG4105KJM monovalent cation h antiporter subunit g BL14DL4_01606 ENOG4105KA0 thioesterase Superfamily protein BL14DL4_01608 ENOG4105BZU Histidine kinase BL14DL4_01614 ENOG4105D58 Diguanylate phosphodiesterase BL14DL4_01615 ENOG4105DAP Nicotinate phosphoribosyltransferase BL14DL4_01620 ENOG4105C02 permease BL14DL4_01621 ENOG4108Z40 Transcriptional regulator BL14DL4_01625 ENOG410904N short-chain dehydrogenase reductase BL14DL4_01632 ENOG4105BZG amino acid carrier protein BL14DL4_01633 ENOG4108K8K Transcriptional regulator BL14DL4_01634 ENOG4105DCF alanine dehydrogenase BL14DL4_01639 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BL14DL4_01641 ENOG41069ER domain protein BL14DL4_01643 ENOG4105CEP NADH dehydrogenase BL14DL4_01644 ENOG4105CAY ferredoxin--nadp reductase BL14DL4_01647 ENOG4108YM7 Gcn5-related n-acetyltransferase BL14DL4_01648 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BL14DL4_01653 ENOG4108ZMX Domain of unknown function (DU1801) BL14DL4_01656 ENOG4105PY6 Phenolic acid decarboxylase BL14DL4_01659 ENOG41083MR nifu domain-containing protein BL14DL4_01660 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BL14DL4_01661 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BL14DL4_01662 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BL14DL4_01663 ENOG4105D6E homoserine dehydrogenase BL14DL4_01664 ENOG4105C5I Dehydrogenase BL14DL4_01666 ENOG4108W5N phosphatidylglycerophosphatase a BL14DL4_01667 ENOG4105D4U had-superfamily hydrolase, subfamily iia BL14DL4_01669 ENOG4105MMD transcriptional regulator BL14DL4_01670 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BL14DL4_01671 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BL14DL4_01672 ENOG4105FAA peptidase M23 BL14DL4_01674 ENOG4105C8J )-transporter BL14DL4_01675 ENOG4108YTE sporulation protein YunB BL14DL4_01676 ENOG4105KZD Domain of unknown function (DUF1805) BL14DL4_01677 ENOG4107R8B 5'-nucleotidase BL14DL4_01679 ENOG4105I3N Conserved Protein BL14DL4_01680 ENOG4105IIP Membrane BL14DL4_01681 ENOG4105W1N transcriptional regulator BL14DL4_01683 ENOG4105C5R Aminotransferase BL14DL4_01685 ENOG4105G9B Transcriptional regulator BL14DL4_01688 ENOG4108I0Q anthranilate phosphoribosyltransferase BL14DL4_01689 ENOG4108I0Q anthranilate phosphoribosyltransferase BL14DL4_01690 ENOG4108K8S endonuclease I BL14DL4_01692 ENOG4107VFR oxidoreductase BL14DL4_01697 ENOG4105DIW FeS assembly protein SUFB BL14DL4_01698 ENOG4108UNV SUF system FeS assembly protein, NifU family BL14DL4_01699 ENOG4105C9B Cysteine desulfurase BL14DL4_01700 ENOG4105JRK feS assembly protein SufD BL14DL4_01701 ENOG4105C3K feS assembly ATPase SufC BL14DL4_01702 ENOG4105PGM cation diffusion facilitator family transporter BL14DL4_01704 ENOG4105D01 (LipO)protein BL14DL4_01705 ENOG4108UMI ABC transporter, permease BL14DL4_01706 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BL14DL4_01711 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BL14DL4_01712 ENOG41080E8 Transcriptional regulator, Spx MgsR family BL14DL4_01713 ENOG4105C1G acyl-Coa dehydrogenase BL14DL4_01714 ENOG4105CHU acetyl-coa acetyltransferase BL14DL4_01721 ENOG4105E0A ABC, transporter BL14DL4_01722 ENOG4108IHU transport system permease protein BL14DL4_01723 ENOG4105DQ5 transport system permease protein BL14DL4_01724 ENOG4108MES Periplasmic binding protein BL14DL4_01727 ENOG4105DZ1 carboxypeptidase BL14DL4_01728 ENOG4105E1F short-chain dehydrogenase reductase BL14DL4_01729 ENOG4105HUF DNA protection during starvation protein BL14DL4_01730 ENOG4105C0H protease BL14DL4_01732 ENOG4105F3H Histidine kinase BL14DL4_01734 ENOG41067SE Tetr family transcriptional regulator BL14DL4_01735 ENOG4105C9Q fumarate hydratase class II BL14DL4_01741 ENOG4105WH1 Two component transcriptional regulator luxr family BL14DL4_01742 ENOG4105ENE Histidine kinase BL14DL4_01745 ENOG41087YS Phage shock protein A BL14DL4_01748 ENOG4108WBT adenosyltransferase BL14DL4_01749 ENOG4105CHR reductase BL14DL4_01750 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BL14DL4_01752 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BL14DL4_01753 ENOG4105E0A ABC, transporter BL14DL4_01754 ENOG4105EHG Permease protein BL14DL4_01755 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BL14DL4_01756 ENOG4105DRR Transcriptional regulator, GntR family BL14DL4_01757 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BL14DL4_01758 ENOG4108RPX mosc domain containing protein BL14DL4_01759 ENOG4105DND Transcriptional regulator BL14DL4_01761 ENOG4105CTX dehydratase BL14DL4_01762 ENOG4107QZW Altronate oxidoreductase BL14DL4_01763 ENOG4107KJX Transcriptional regulator BL14DL4_01764 ENOG4105CT4 transporter BL14DL4_01765 ENOG4105D2H Uronic isomerase BL14DL4_01767 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BL14DL4_01768 ENOG4105E0A ABC, transporter BL14DL4_01769 ENOG4105EHG Permease protein BL14DL4_01770 ENOG4105DQ5 transport system permease protein BL14DL4_01771 ENOG4105D5Q Arginine ornithine antiporter BL14DL4_01772 ENOG4107K5X Membrane-bound metal-dependent hydrolase BL14DL4_01773 ENOG4107QZ2 Sulfatase BL14DL4_01776 ENOG4105EVU fructokinase BL14DL4_01777 ENOG4107EPV Aminotransferase class V BL14DL4_01779 ENOG4105EEM helicase BL14DL4_01780 ENOG4105EN6 Membrane BL14DL4_01781 ENOG4105RHY Pfam:UPF0157 BL14DL4_01783 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BL14DL4_01785 ENOG4107ZQN disulfide bond BL14DL4_01786 ENOG4105C59 p-type ATPase BL14DL4_01787 ENOG4108JE9 extracellular solute-binding protein family 1 BL14DL4_01788 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BL14DL4_01789 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BL14DL4_01790 ENOG4105CJQ hydrolase, family 31 BL14DL4_01792 ENOG4105DIK (ABC) transporter BL14DL4_01793 ENOG4105CC5 ABC transporter BL14DL4_01794 ENOG4105DSE periplasmic solute binding protein BL14DL4_01796 ENOG4105HX0 Transcriptional regulator BL14DL4_01797 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) BL14DL4_01798 ENOG4105DM4 PTS System BL14DL4_01802 ENOG4105C59 p-type ATPase BL14DL4_01803 ENOG410681U heavy metal transport detoxification protein BL14DL4_01804 ENOG4105VPX protein, conserved in bacteria BL14DL4_01805 ENOG4107RKG DJ-1/PfpI family BL14DL4_01806 ENOG4105E98 transcriptional regulator DeoR family BL14DL4_01807 ENOG4105DET Rhamnulokinase BL14DL4_01808 ENOG4105C9F isomerase BL14DL4_01811 ENOG4105F27 Major Facilitator BL14DL4_01813 ENOG410625E BL14DL4_01814 ENOG4106A3M Cytochrome p-450 BL14DL4_01818 ENOG4105D9R oxidoreductase BL14DL4_01821 ENOG4105C72 UPF0176 protein BL14DL4_01823 ENOG4106DF4 Sigma-70, region 4 BL14DL4_01825 ENOG4105F0F Oxalate decarboxylase BL14DL4_01842 ENOG41068G1 BL14DL4_01844 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BL14DL4_01846 ENOG4108FKH Transglycosylase SLT domain BL14DL4_01856 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BL14DL4_01859 ENOG4105CAR Terminase, large subunit BL14DL4_01887 ENOG4108IMY Transcriptional regulator BL14DL4_01890 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BL14DL4_01891 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BL14DL4_01893 ENOG4105XZU Preprotein translocase, subunit SecG BL14DL4_01898 ENOG4105R40 Glycine betaine carnitine choline BL14DL4_01899 ENOG4108HQR Glycine betaine BL14DL4_01900 ENOG4105E90 ABC transporter BL14DL4_01901 ENOG4108IJ8 ABC transporter BL14DL4_01902 ENOG4107HG4 Transcriptional regulator BL14DL4_01903 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BL14DL4_01905 ENOG4105T65 Membrane-associated protein BL14DL4_01907 ENOG4108MES Periplasmic binding protein BL14DL4_01909 ENOG4108V4B ThiJ pfpI BL14DL4_01910 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BL14DL4_01911 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BL14DL4_01912 ENOG4105CP7 Triose-phosphate isomerase BL14DL4_01913 ENOG4105BZA Phosphoglycerate kinase BL14DL4_01914 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BL14DL4_01916 ENOG4105DEN Luciferase family BL14DL4_01919 ENOG4105CIG ABC transporter BL14DL4_01923 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BL14DL4_01924 ENOG4105JXH GntR family transcriptional regulator BL14DL4_01925 ENOG4105DAA L-lactate BL14DL4_01926 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BL14DL4_01928 ENOG4108ZPC Polysaccharide pyruvyl transferase BL14DL4_01929 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BL14DL4_01930 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BL14DL4_01931 ENOG4105D3Q Sugar transferase BL14DL4_01933 ENOG4105K64 Glycosyl transferase, family 2 BL14DL4_01935 ENOG4107QRS glycosyltransferase group 2 family protein BL14DL4_01936 ENOG41068W6 Capsular polysaccharide biosynthesis protein BL14DL4_01937 ENOG4108KMV Glycosyl transferase (Group 1 BL14DL4_01938 ENOG4105K64 Glycosyl transferase, family 2 BL14DL4_01939 ENOG4108PQP glycosyl transferase group 1 BL14DL4_01941 ENOG4108QV3 biosynthesis protein BL14DL4_01942 ENOG4105HTX biosynthesis protein BL14DL4_01945 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BL14DL4_01946 ENOG4108I5G Major Facilitator superfamily BL14DL4_01948 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BL14DL4_01949 ENOG4107S2N Type III effector Hrp-dependent BL14DL4_01951 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BL14DL4_01954 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BL14DL4_01955 ENOG4105EDQ levansucrase EC 2.4.1.10 BL14DL4_01956 ENOG4108HKT sucrose-6-phosphate hydrolase BL14DL4_01959 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BL14DL4_01960 ENOG4108URH decarboxylase BL14DL4_01961 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BL14DL4_01962 ENOG4107TVP HD domain protein BL14DL4_01963 ENOG4105CHH sulfate transporter BL14DL4_01964 ENOG4108V2W Carbonate dehydratase BL14DL4_01965 ENOG4105C5I Dehydrogenase BL14DL4_01966 ENOG4108SQ9 flavin reductase domain protein, FMN-binding BL14DL4_01967 ENOG4108ZHR arsR family transcriptional regulator BL14DL4_01970 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BL14DL4_01971 ENOG4105KRI phosphocarrier protein (HPr BL14DL4_01972 ENOG4105CIE May be required for sporulation (By similarity) BL14DL4_01973 ENOG4105CHW UPF0052 protein BL14DL4_01974 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BL14DL4_01975 ENOG4108Z4K mutator MutT protein BL14DL4_01976 ENOG4105C3M thioredoxin reductase BL14DL4_01979 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BL14DL4_01980 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BL14DL4_01981 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BL14DL4_01982 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BL14DL4_01983 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BL14DL4_01984 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BL14DL4_01985 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BL14DL4_01986 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BL14DL4_01988 ENOG4108E16 pectate lyase BL14DL4_01989 ENOG4108S4C acetyltransferase BL14DL4_01990 ENOG4107XGZ Hydrolase BL14DL4_01991 ENOG4105HKU nucleoside recognition domain-containing protein BL14DL4_01993 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BL14DL4_01994 ENOG410834F Transcriptional regulator BL14DL4_01995 ENOG4105C0R drug resistance transporter emrb qaca subfamily BL14DL4_01996 ENOG41088CQ domain protein BL14DL4_01997 ENOG41086DT Membrane protein of unknown function BL14DL4_01998 ENOG41067S9 phage shock protein C, PspC BL14DL4_01999 ENOG4108PY7 BL14DL4_02003 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BL14DL4_02004 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BL14DL4_02009 ENOG4105CN1 protease BL14DL4_02010 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BL14DL4_02012 ENOG4105CRP Part of the ABC transporter FtsEX involved in BL14DL4_02013 ENOG4105CAK Cell division ATP-binding protein ftsE BL14DL4_02016 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BL14DL4_02017 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BL14DL4_02018 ENOG4105MS2 ribosomal subunit Interface protein BL14DL4_02021 ENOG4105MQ3 flagellar protein FliS BL14DL4_02022 ENOG4107RT6 flagellar hook-associated BL14DL4_02023 ENOG41083S7 flagellar protein FlaG BL14DL4_02024 ENOG4105I03 Flagellin BL14DL4_02025 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BL14DL4_02026 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BL14DL4_02027 ENOG4105MKD BL14DL4_02028 ENOG4105DTJ flagellar hook-associated protein BL14DL4_02029 ENOG4105E1Q flagellar hook-associated protein BL14DL4_02032 ENOG4105RU3 BL14DL4_02036 ENOG4105WH1 Two component transcriptional regulator luxr family BL14DL4_02037 ENOG4105BZU Histidine kinase BL14DL4_02038 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BL14DL4_02039 ENOG4108KGH TRANSCRIPTIONal BL14DL4_02041 ENOG4105ESV Glycosyl transferase, family 4 BL14DL4_02042 ENOG4107EF8 Glycosyl transferase (Group 1 BL14DL4_02045 ENOG4105QZI O-Antigen Polymerase BL14DL4_02046 ENOG4105C1B dTDP-glucose 4-6-dehydratase BL14DL4_02047 ENOG4105C6Y Udp-glucose 6-dehydrogenase BL14DL4_02048 ENOG4107RA4 Glycosyl transferase (Group 1 BL14DL4_02049 ENOG4105PSV Polysaccharide Biosynthesis Protein BL14DL4_02050 ENOG4105D3Q Sugar transferase BL14DL4_02051 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BL14DL4_02052 ENOG4105JFG SpoIID LytB domain protein BL14DL4_02054 ENOG4108KGH TRANSCRIPTIONal BL14DL4_02055 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BL14DL4_02056 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BL14DL4_02057 ENOG4105EY8 ABC transporter BL14DL4_02059 ENOG4107SJB teichoic acid biosynthesis BL14DL4_02061 ENOG4107SJB teichoic acid biosynthesis BL14DL4_02062 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BL14DL4_02064 ENOG4107RZX Teichoic acid biosynthesis protein BL14DL4_02066 ENOG4105DG6 mannose-6-phosphate isomerase BL14DL4_02068 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BL14DL4_02069 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) BL14DL4_02070 ENOG4108UHU Aldolase BL14DL4_02071 ENOG4105D7K pfkb domain protein BL14DL4_02072 ENOG4108M60 Transcriptional regulator BL14DL4_02074 ENOG4105CHR reductase BL14DL4_02075 ENOG4105E2A Dehydrogenase BL14DL4_02077 ENOG4105C54 Major Facilitator superfamily BL14DL4_02078 ENOG4108KGH TRANSCRIPTIONal BL14DL4_02079 ENOG4105J7I hydrolase BL14DL4_02080 ENOG4105K4H Nlp p60 protein BL14DL4_02082 ENOG4105PNM synthesis protein BL14DL4_02084 ENOG4105N98 Capsule biosynthesis protein capB BL14DL4_02085 ENOG4105ETE Transcriptional regulator (LacI family BL14DL4_02086 ENOG4108RVA ribokinase BL14DL4_02087 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BL14DL4_02088 ENOG4105C2J ABC transporter BL14DL4_02089 ENOG4105CNN ABC, transporter BL14DL4_02090 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BL14DL4_02091 ENOG4107FQX Alpha-acetolactate decarboxylase BL14DL4_02093 ENOG4107RSM transcriptional regulator BL14DL4_02094 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BL14DL4_02096 ENOG4105CAH Chromate BL14DL4_02097 ENOG4105FGV Chromate BL14DL4_02098 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BL14DL4_02099 ENOG4105HTX biosynthesis protein BL14DL4_02101 ENOG4105KBK Zinc finger, swim domain protein BL14DL4_02102 ENOG4105C0D helicase BL14DL4_02104 ENOG410667J hydrolase BL14DL4_02105 ENOG4105E98 transcriptional regulator DeoR family BL14DL4_02107 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase BL14DL4_02108 ENOG4105VI0 Pts system, glucitol sorbitol-specific BL14DL4_02109 ENOG4105DZY Pts system, glucitol sorbitol-specific BL14DL4_02110 ENOG410787A Pts system, glucitol sorbitol-specific BL14DL4_02112 ENOG4105DKT Transcriptional regulator BL14DL4_02113 ENOG4105Z8H single-stranded DNA-binding protein BL14DL4_02117 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BL14DL4_02118 ENOG4105CGA flagellar basal-body rod protein FlgG BL14DL4_02120 ENOG4105DFF Rod shape-determining protein mreb BL14DL4_02121 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BL14DL4_02122 ENOG4107MII Sugar-specific transcriptional regulator TrmB BL14DL4_02123 ENOG4105CZM Major Facilitator BL14DL4_02124 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BL14DL4_02125 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BL14DL4_02127 ENOG4108NA0 Uncharacterized conserved protein (COG2071) BL14DL4_02128 ENOG41080XP Cbs domain BL14DL4_02130 ENOG4105C37 (CBS) domain BL14DL4_02131 ENOG4105BZU Histidine kinase BL14DL4_02135 ENOG4105FRN stage II sporulation protein BL14DL4_02136 ENOG4107TCE N-acetyltransferase BL14DL4_02138 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BL14DL4_02140 ENOG4105C0R drug resistance transporter emrb qaca subfamily BL14DL4_02141 ENOG4105WQT MbtH domain protein BL14DL4_02142 ENOG4105CEY Amp-dependent synthetase and ligase BL14DL4_02143 ENOG4105WQI isochorismatase BL14DL4_02144 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BL14DL4_02145 ENOG4105E4F Isochorismate synthase BL14DL4_02146 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BL14DL4_02147 ENOG4105NIV Esterase BL14DL4_02151 ENOG410874W AraC family transcriptional regulator BL14DL4_02153 ENOG4108RYK Nad-dependent epimerase dehydratase BL14DL4_02154 ENOG4108Z40 Transcriptional regulator BL14DL4_02157 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BL14DL4_02158 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BL14DL4_02159 ENOG4105FCD Major Facilitator BL14DL4_02160 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BL14DL4_02161 ENOG4108TF4 von Willebrand factor, type A BL14DL4_02164 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BL14DL4_02166 ENOG4106778 Protein of unknown function (DUF1146) BL14DL4_02167 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BL14DL4_02168 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BL14DL4_02169 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BL14DL4_02170 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BL14DL4_02171 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BL14DL4_02174 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BL14DL4_02176 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BL14DL4_02177 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BL14DL4_02178 ENOG4108UIC UPF0340 protein BL14DL4_02179 ENOG4108YZG isomerase BL14DL4_02180 ENOG4107WAU Protein tyrosine phosphatase BL14DL4_02181 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BL14DL4_02182 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BL14DL4_02184 ENOG4108ZXQ stage ii sporulation protein r BL14DL4_02187 ENOG4105TRI Hydrolase BL14DL4_02190 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BL14DL4_02191 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BL14DL4_02192 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BL14DL4_02194 ENOG4107TT2 Auxin Efflux Carrier BL14DL4_02195 ENOG4105C6K Malic enzyme BL14DL4_02196 ENOG4107104 thymidine kinase BL14DL4_02197 ENOG41082DI 50s ribosomal protein l31 BL14DL4_02198 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BL14DL4_02199 ENOG4105CBT Fructose-1,6-bisphosphatase BL14DL4_02200 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BL14DL4_02201 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway BL14DL4_02202 ENOG4105D2N Aldolase BL14DL4_02203 ENOG410812K response regulator receiver protein BL14DL4_02205 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BL14DL4_02207 ENOG4105C1G acyl-Coa dehydrogenase BL14DL4_02208 ENOG4105C1G acyl-Coa dehydrogenase BL14DL4_02209 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BL14DL4_02211 ENOG4105DF6 Fe-S oxidoreductase BL14DL4_02214 ENOG4105C75 arginyL-tRNA synthetase BL14DL4_02215 ENOG410684U Domain of unknown function (DUF1934) BL14DL4_02216 ENOG4105CYW agmatinase BL14DL4_02217 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BL14DL4_02219 ENOG4105BZ4 penicillin-binding protein BL14DL4_02220 ENOG4108XFG YwhD family BL14DL4_02221 ENOG4108Z4T Peptidase M50 BL14DL4_02222 ENOG41069HH 4-oxalocrotonate tautomerase BL14DL4_02225 ENOG4105DCI Phosphohydrolase BL14DL4_02227 ENOG4108VCI transcription factor, rsfa family BL14DL4_02229 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BL14DL4_02231 ENOG4105D2S major facilitator superfamily BL14DL4_02236 ENOG4108FUF Transcriptional regulator, IclR family BL14DL4_02238 ENOG4108IJ2 phosphate acetyltransferase BL14DL4_02239 ENOG4107JTW chlorite dismutase BL14DL4_02241 ENOG4105CZN Potassium uptake protein BL14DL4_02245 ENOG4105CJ1 ABC, transporter BL14DL4_02251 ENOG4105C26 Dehydrogenase BL14DL4_02252 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BL14DL4_02253 ENOG4108RJ9 Glycosyl transferase, family 2 BL14DL4_02254 ENOG4105DWF phosphomethylpyrimidine kinase BL14DL4_02257 ENOG4105C5Y PTS System BL14DL4_02261 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BL14DL4_02263 ENOG4105DEN Luciferase family BL14DL4_02265 ENOG4108DBC nitroreductase BL14DL4_02269 ENOG4105DWD nucleoside recognition domain protein BL14DL4_02281 ENOG41060D1 Quinol oxidase BL14DL4_02283 ENOG4105BZ9 Cytochrome C oxidase, subunit I BL14DL4_02284 ENOG4105E2S oxidase) subunit II BL14DL4_02285 ENOG4105CMR udp-glucose 4-epimerase BL14DL4_02289 ENOG4108WS4 fmn reductase BL14DL4_02292 ENOG4105CMG Carbohydrate kinase BL14DL4_02293 ENOG4105C93 Xylose Isomerase BL14DL4_02295 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BL14DL4_02296 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BL14DL4_02297 ENOG4105CMU LysR family (Transcriptional regulator BL14DL4_02301 ENOG41067MG lrgb family BL14DL4_02303 ENOG4105CK7 Sodium proline symporter BL14DL4_02304 ENOG4105DR4 Methyltransferase BL14DL4_02306 ENOG4105C5I Dehydrogenase BL14DL4_02307 ENOG4105X1N Glycosyl transferase family 8 BL14DL4_02310 ENOG4105ENE Histidine kinase BL14DL4_02311 ENOG4108VB1 regulatoR BL14DL4_02312 ENOG4105EYF MMPL domain protein BL14DL4_02314 ENOG4105DJB Major Facilitator Superfamily BL14DL4_02315 ENOG4105CXK mandelate racemase muconate lactonizing BL14DL4_02316 ENOG4108UHU Aldolase BL14DL4_02317 ENOG4105D7K pfkb domain protein BL14DL4_02319 ENOG4105IIU Aminopeptidase BL14DL4_02320 ENOG41080V3 Major Facilitator superfamily BL14DL4_02325 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BL14DL4_02326 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BL14DL4_02327 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) BL14DL4_02328 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BL14DL4_02329 ENOG4105CM2 brancheD-chain amino acid aminotransferase BL14DL4_02331 ENOG4105F8D glycoside hydrolase family 4 BL14DL4_02332 ENOG4105VCP PTS System BL14DL4_02333 ENOG4105CK1 PTS System BL14DL4_02334 ENOG4105VZJ PTS System BL14DL4_02335 ENOG4105EMD TRANSCRIPTIONal BL14DL4_02337 ENOG4108VX5 3-methyladenine DNA glycosylase BL14DL4_02340 ENOG4105DXD 2-methylcitrate dehydratase BL14DL4_02341 ENOG4105CR4 methylisocitrate lyase BL14DL4_02344 ENOG4105BZ1 (ABC) transporter BL14DL4_02345 ENOG4107TDE lipolytic protein G-D-S-L family BL14DL4_02348 ENOG4105C2C drug resistance transporter, Bcr CflA BL14DL4_02350 ENOG4105DA5 (ABC) transporter BL14DL4_02351 ENOG41069JR BL14DL4_02356 ENOG4105CH6 catalase BL14DL4_02358 ENOG4105G5W regulator Fur family BL14DL4_02359 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BL14DL4_02360 ENOG4108TU7 Inherit from COG: (ABC) transporter BL14DL4_02361 ENOG4105CJ1 ABC, transporter BL14DL4_02364 ENOG4105CJ1 ABC, transporter BL14DL4_02374 ENOG4108J20 pectate lyase BL14DL4_02375 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BL14DL4_02376 ENOG4108JJ8 (ABC) transporter BL14DL4_02377 ENOG4108JJ9 ABC, transporter BL14DL4_02378 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BL14DL4_02379 ENOG4105C4M (Ubiquinol oxidase) subunit I BL14DL4_02380 ENOG4108QTI )-transporter BL14DL4_02383 ENOG4105DFD Na H antiporter BL14DL4_02384 ENOG4108IJ0 Aspartate ammonia-lyase BL14DL4_02385 ENOG4105HDK L-asparaginase BL14DL4_02386 ENOG4108IMY Transcriptional regulator BL14DL4_02387 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BL14DL4_02395 ENOG4107BJW polysaccharide deacetylase BL14DL4_02396 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BL14DL4_02397 ENOG4107QZ7 Cellulose synthase catalytic subunit BL14DL4_02398 ENOG4105D2K citrate carrier protein BL14DL4_02399 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BL14DL4_02400 ENOG4105X3H Excalibur domain protein BL14DL4_02402 ENOG4105E0M Sulfatase BL14DL4_02404 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BL14DL4_02406 ENOG4105CEU Arginine dihydrolase BL14DL4_02407 ENOG4105DBV ornithine carbamoyltransferase BL14DL4_02409 ENOG4105C5B carbamate kinase BL14DL4_02411 ENOG4105CS2 ec 3.2.1.21 BL14DL4_02412 ENOG4105CK1 PTS System BL14DL4_02414 ENOG4105JVQ RNA Polymerase BL14DL4_02416 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BL14DL4_02417 ENOG4107R3K hydrolase BL14DL4_02418 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BL14DL4_02419 ENOG4105ETE Transcriptional regulator (LacI family BL14DL4_02424 ENOG4105EDW glycosyl transferase, family 39 BL14DL4_02425 ENOG4105CKK Glycosyl transferase, family 2 BL14DL4_02426 ENOG4105CMR udp-glucose 4-epimerase BL14DL4_02432 ENOG4105CH6 catalase BL14DL4_02434 ENOG4105CS2 ec 3.2.1.21 BL14DL4_02435 ENOG4105C5Y PTS System BL14DL4_02436 ENOG4105CID antiterminator BL14DL4_02437 ENOG4108W7F transporter, permease BL14DL4_02438 ENOG4108JJB ABC transporter BL14DL4_02439 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BL14DL4_02440 ENOG4105ETU transcriptional activator (TenA BL14DL4_02443 ENOG4107QP3 malate synthase g BL14DL4_02445 ENOG4105EDW glycosyl transferase, family 39 BL14DL4_02447 ENOG4105C19 ABC transporter BL14DL4_02448 ENOG4105EWM Histidine kinase BL14DL4_02450 ENOG4105CS2 ec 3.2.1.21 BL14DL4_02451 ENOG4105C5Y PTS System BL14DL4_02453 ENOG4107QHE Choloylglycine hydrolase BL14DL4_02456 ENOG4106Z5D Glycoside Hydrolase Family 43 BL14DL4_02457 ENOG4105C1J atp-dependent rna helicase BL14DL4_02463 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BL14DL4_02464 ENOG4105D9N nucleoside BL14DL4_02465 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BL14DL4_02466 ENOG4107RHR regulatoR BL14DL4_02470 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BL14DL4_02471 ENOG4107R8N Glycosyl transferase, family 2 BL14DL4_02473 ENOG4105JKW Valine--pyruvate aminotransferase BL14DL4_02478 ENOG4105D2N Aldolase BL14DL4_02479 ENOG4107TRN Xylose isomerase domain protein TIM barrel BL14DL4_02480 ENOG4105F0H myo-inositol catabolism protein BL14DL4_02481 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BL14DL4_02483 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BL14DL4_02484 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) BL14DL4_02485 ENOG4105D7K pfkb domain protein BL14DL4_02486 ENOG4105DH8 myo-inositol catabolism BL14DL4_02487 ENOG4105C26 Dehydrogenase BL14DL4_02489 ENOG4105CPC Aldo Keto reductase BL14DL4_02490 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BL14DL4_02491 ENOG4105CXY transporter BL14DL4_02492 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BL14DL4_02493 ENOG4105C5H ABC transporter BL14DL4_02494 ENOG410667J hydrolase BL14DL4_02496 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BL14DL4_02498 ENOG4108V5C ABC transporter BL14DL4_02503 ENOG4105H93 Acyltransferase family BL14DL4_02509 ENOG4105EC8 Methyl-accepting chemotaxis BL14DL4_02510 ENOG4105BZG amino acid carrier protein BL14DL4_02511 ENOG4105DCF alanine dehydrogenase BL14DL4_02514 ENOG4105EG2 ABC transporter, permease BL14DL4_02516 ENOG4107FKK extracellular solute-binding protein family 1 BL14DL4_02518 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BL14DL4_02519 ENOG4105CMR udp-glucose 4-epimerase BL14DL4_02520 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BL14DL4_02521 ENOG4105E2R ROK family BL14DL4_02523 ENOG4105CMG Carbohydrate kinase BL14DL4_02526 ENOG4108EKI Dehydrogenase BL14DL4_02527 ENOG4105D3R alkyl hydroperoxide reductase BL14DL4_02528 ENOG4108JU3 Alkyl hydroperoxide reductase BL14DL4_02533 ENOG4108M15 ABC transporter BL14DL4_02534 ENOG4105KCT ABC transporter BL14DL4_02535 ENOG4105BZU Histidine kinase BL14DL4_02542 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BL14DL4_02545 ENOG4105WQG acetyltransferase BL14DL4_02548 ENOG4105C0H protease BL14DL4_02549 ENOG4105Q2H domain protein BL14DL4_02552 ENOG4105BZU Histidine kinase BL14DL4_02553 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BL14DL4_02559 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BL14DL4_02561 ENOG4105CDU Replicative dna helicase BL14DL4_02565 ENOG4105DJ2 Major Facilitator Superfamily BL14DL4_02566 ENOG4105CE4 GlcNAc 6-P deacetylase BL14DL4_02567 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BL14DL4_02568 ENOG4105FDP GntR family transcriptional regulator BL14DL4_02569 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BL14DL4_02572 ENOG4105BZR domain protein BL14DL4_02573 ENOG4108XMW Membrane BL14DL4_02575 ENOG4107YZX Universal stress protein BL14DL4_02576 ENOG4105CHH sulfate transporter BL14DL4_02578 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BL14DL4_02579 ENOG4108UUM single-stranded DNA-binding protein BL14DL4_02580 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BL14DL4_02581 ENOG4105C3G gtp-binding protein BL14DL4_02582 ENOG4105VDK protein, conserved in bacteria BL14DL4_02584 ENOG4108ZDA Sporulation protein YyaC BL14DL4_02585 ENOG4105FA0 parb-like partition protein BL14DL4_02586 ENOG4107QJE Chromosome Partitioning Protein BL14DL4_02587 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BL14DL4_02589 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) BL14DL4_02591 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BL14DL4_02592 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BL14DL4_02595 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BL14DL4_02596 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BL14DL4_02597 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BL14DL4_02598 ENOG410848D S4 domain protein YaaA BL14DL4_02599 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BL14DL4_02600 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BL14DL4_02601 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BL14DL4_02608 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BL14DL4_02610 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BL14DL4_02611 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BL14DL4_02612 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BL14DL4_02613 ENOG4105BZW Glycerate kinase BL14DL4_02614 ENOG4107QQ0 gntp family BL14DL4_02615 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BL14DL4_02618 ENOG4105ZMH deoxynucleoside kinase BL14DL4_02620 ENOG4105VRS hydrolase family 18 BL14DL4_02621 ENOG4105GTG Isochorismatase BL14DL4_02622 ENOG4108Z6B deaminase BL14DL4_02623 ENOG4105C6E dna polymerase iii BL14DL4_02624 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BL14DL4_02625 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BL14DL4_02627 ENOG41067KS pro-sigma K processing BL14DL4_02635 ENOG4105CDW Resistance protein BL14DL4_02636 ENOG4105CXN decarboxylase BL14DL4_02637 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BL14DL4_02638 ENOG4105X0R protein from nitrogen regulatory protein P-II BL14DL4_02639 ENOG4105XVJ Protein of unknown function (DUF327) BL14DL4_02640 ENOG4105FA2 dna polymerase iii BL14DL4_02641 ENOG4105MA4 psp1 domain protein BL14DL4_02642 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) BL14DL4_02643 ENOG41060K3 Methyltransferase BL14DL4_02644 ENOG4105VC4 domain protein BL14DL4_02645 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BL14DL4_02646 ENOG4105KRN Transcriptional regulator, abrb family BL14DL4_02647 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BL14DL4_02648 ENOG4105F8V Hydrolase, tatD family BL14DL4_02649 ENOG41069ER domain protein BL14DL4_02651 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BL14DL4_02652 ENOG4105XFA sporulation peptidase YabG BL14DL4_02653 ENOG4105W42 Veg protein BL14DL4_02654 ENOG4105XEW small acid-soluble spore protein BL14DL4_02656 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BL14DL4_02657 ENOG4105DFT pur operon repressor BL14DL4_02658 ENOG4105KME endoribonuclease L-psp BL14DL4_02659 ENOG4105K4W Could be involved in septation (By similarity) BL14DL4_02660 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BL14DL4_02661 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BL14DL4_02662 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BL14DL4_02665 ENOG4108JA2 transcriptioN-repair coupling factor BL14DL4_02666 ENOG4108M14 stage v sporulation protein t BL14DL4_02668 ENOG4108IY2 MazG family BL14DL4_02669 ENOG41082I2 s4 domain protein BL14DL4_02670 ENOG4105VYY sporulation protein yabp BL14DL4_02673 ENOG41060GV RNA binding s1 domain protein BL14DL4_02679 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BL14DL4_02680 ENOG4108UGV hypoxanthine phosphoribosyltransferase BL14DL4_02681 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BL14DL4_02682 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BL14DL4_02683 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BL14DL4_02684 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BL14DL4_02685 ENOG4105C6T cysteine synthase BL14DL4_02686 ENOG4105CRQ synthase (Component I) BL14DL4_02687 ENOG4105DDQ anthranilate synthase BL14DL4_02688 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BL14DL4_02689 ENOG4105EEI dihydropteroate synthase BL14DL4_02690 ENOG4105KRF dihydroneopterin aldolase BL14DL4_02691 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BL14DL4_02693 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BL14DL4_02694 ENOG4105CRK lysyL-tRNA synthetase BL14DL4_02711 ENOG4108Z0C Uvrb UvrC protein BL14DL4_02712 ENOG41066A3 ATP guanido phosphotransferase BL14DL4_02714 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BL14DL4_02715 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BL14DL4_02716 ENOG4105CTP PilT protein domain protein BL14DL4_02717 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BL14DL4_02718 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BL14DL4_02719 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BL14DL4_02720 ENOG4105D7W serine acetyltransferase BL14DL4_02721 ENOG4105C8N cysteinyl-tRNA synthetase BL14DL4_02722 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BL14DL4_02723 ENOG4105C2N RNA methyltransferase TrmH family group 3 BL14DL4_02724 ENOG4105M0M Tetracycline resistance protein BL14DL4_02725 ENOG4105QIV RNA polymerase BL14DL4_02726 ENOG410683Z Preprotein translocase SecE subunit BL14DL4_02727 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BL14DL4_02728 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BL14DL4_02729 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BL14DL4_02730 ENOG4108VZM 50s ribosomal protein L10 BL14DL4_02731 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BL14DL4_02732 ENOG4107Y49 methyltransferase BL14DL4_02733 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BL14DL4_02734 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BL14DL4_02735 ENOG4105XPM ribosomal protein BL14DL4_02736 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BL14DL4_02737 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BL14DL4_02738 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BL14DL4_02739 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BL14DL4_02740 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BL14DL4_02741 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BL14DL4_02742 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BL14DL4_02743 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BL14DL4_02744 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BL14DL4_02745 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BL14DL4_02746 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BL14DL4_02747 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BL14DL4_02748 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BL14DL4_02749 ENOG41082SA 50s ribosomal protein l29 BL14DL4_02750 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BL14DL4_02751 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BL14DL4_02752 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BL14DL4_02753 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BL14DL4_02754 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BL14DL4_02755 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BL14DL4_02756 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BL14DL4_02757 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BL14DL4_02758 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BL14DL4_02759 ENOG4105VPB 50S ribosomal protein L30 BL14DL4_02760 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BL14DL4_02761 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BL14DL4_02762 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BL14DL4_02763 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BL14DL4_02765 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BL14DL4_02767 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BL14DL4_02768 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BL14DL4_02769 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BL14DL4_02770 ENOG4108ZT0 50S ribosomal protein l17 BL14DL4_02771 ENOG4108JJB ABC transporter BL14DL4_02772 ENOG4108JJB ABC transporter BL14DL4_02773 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BL14DL4_02774 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BL14DL4_02775 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BL14DL4_02776 ENOG4108UJD 30S ribosomal protein S9 BL14DL4_02780 ENOG4105D1F ATP-binding protein BL14DL4_02783 ENOG4108NMV polysaccharide deacetylase BL14DL4_02790 ENOG4108A04 Beta-lactamase BL14DL4_02794 ENOG4105JAB phenazine biosynthesis protein, phzf family BL14DL4_02795 ENOG4105EHZ conserved protein UCP016719 BL14DL4_02796 ENOG4105D17 glycoside hydrolase, family 3 domain protein BL14DL4_02800 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BL14DL4_02801 ENOG4105EWC Purine nucleoside phosphorylase BL14DL4_02808 ENOG4105EMN RNA polymerase sigma factor BL14DL4_02810 ENOG4105C8B TIGR00159 family BL14DL4_02811 ENOG4107U5W ybbr family BL14DL4_02812 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BL14DL4_02813 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BL14DL4_02817 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BL14DL4_02818 ENOG4105WAB arsR family transcriptional regulator BL14DL4_02819 ENOG4108RWP Major Facilitator Superfamily protein BL14DL4_02821 ENOG4105BZ1 (ABC) transporter BL14DL4_02822 ENOG4107ZXU DSBA oxidoreductase BL14DL4_02825 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BL14DL4_02831 ENOG4108MRH transcriptional regulatory protein BL14DL4_02833 ENOG4105DUM transcriptional regulator, lysR family BL14DL4_02835 ENOG4105E5W Transporter BL14DL4_02836 ENOG4106DDH Sporulation-specific SASP protein BL14DL4_02839 ENOG4105C7Z Conserved Protein BL14DL4_02840 ENOG4107KNS BL14DL4_02843 ENOG41068SY BL14DL4_02844 ENOG4105C7Z Conserved Protein BL14DL4_02845 ENOG4105DXI Major Facilitator superfamily BL14DL4_02850 ENOG4107I77 yiaA/B two helix domain BL14DL4_02855 ENOG410631K Membrane BL14DL4_02856 ENOG4106AXJ AraC family transcriptional regulator BL14DL4_02860 ENOG4107SCQ Iron-containing alcohol dehydrogenase BL14DL4_02861 ENOG4105C8Q Methyl-accepting chemotaxis BL14DL4_02862 ENOG4105DFW ABC transporter BL14DL4_02865 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid BL14DL4_02867 ENOG4108IQI permease BL14DL4_02868 ENOG4108J5H Homocysteine s-methyltransferase BL14DL4_02870 ENOG4105CI1 PTS System BL14DL4_02871 ENOG4107TXC Transcriptional regulator BL14DL4_02872 ENOG4108QY0 Membrane BL14DL4_02876 ENOG4105CSV Glutaminase BL14DL4_02879 ENOG4105KNA -acetyltransferase BL14DL4_02881 ENOG4105NA0 Transcriptional regulator BL14DL4_02883 ENOG4105DGI Alkaline phosphatase BL14DL4_02884 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BL14DL4_02885 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BL14DL4_02886 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase BL14DL4_02887 ENOG4105C26 Dehydrogenase BL14DL4_02888 ENOG4105DJB Major Facilitator Superfamily BL14DL4_02889 ENOG4105EQX glucarate dehydratase BL14DL4_02890 ENOG41073TP transcriptional regulator BL14DL4_02891 ENOG4105CTX dehydratase BL14DL4_02892 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BL14DL4_02893 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BL14DL4_02898 ENOG4108R1P BL14DL4_02899 ENOG4106K80 BL14DL4_02901 ENOG41067TZ transcriptional regulator, MarR family BL14DL4_02906 ENOG4107TXC Transcriptional regulator BL14DL4_02911 ENOG4106UX7 integral membrane protein BL14DL4_02913 ENOG41060AI SEC-C motif BL14DL4_02914 ENOG4105DA5 (ABC) transporter BL14DL4_02919 ENOG4108KSA LysR family transcriptional regulator BL14DL4_02920 ENOG4105MDS 4-oxalocrotonate tautomerase BL14DL4_02926 ENOG4108W0I acetyltransferase BL14DL4_02928 ENOG4105DPN Oligoendopeptidase f BL14DL4_02929 ENOG4107BMA Transglycosylase associated protein BL14DL4_02931 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BL14DL4_02932 ENOG4105CQB FAD linked oxidase domain protein BL14DL4_02933 ENOG4105VZJ PTS System BL14DL4_02934 ENOG4105VCP PTS System BL14DL4_02935 ENOG4105CK1 PTS System BL14DL4_02936 ENOG4105F8D glycoside hydrolase family 4 BL14DL4_02937 ENOG4108X79 transcriptional regulator BL14DL4_02938 ENOG410901P UPF0249 protein BL14DL4_02941 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases BL14DL4_02942 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BL14DL4_02945 ENOG4105KHC sulfurtransferase BL14DL4_02947 ENOG4105DEN Luciferase family BL14DL4_02948 ENOG4105Z8B NlpC/P60 family BL14DL4_02950 ENOG4105CIG ABC transporter BL14DL4_02951 ENOG4108RZE Tetr family transcriptional regulator BL14DL4_02955 ENOG4108N0M stress protein BL14DL4_02956 ENOG4106FN3 tellurium resistance protein BL14DL4_02957 ENOG4106FN3 tellurium resistance protein BL14DL4_02958 ENOG4107TS3 membrane protein, TerC BL14DL4_02961 ENOG4108TTB tellurium resistance protein BL14DL4_02963 ENOG4107QIV Cytochrome c biogenesis protein BL14DL4_02965 ENOG4107SWG transcriptional regulator MERR family BL14DL4_02972 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BL14DL4_02973 ENOG410756H nucleotidyltransferase BL14DL4_02975 ENOG4105C26 Dehydrogenase BL14DL4_02976 ENOG4105CK7 Sodium proline symporter BL14DL4_02977 ENOG4107YHD transcriptional regulator BL14DL4_02979 ENOG4108PJD permease BL14DL4_02980 ENOG4105I82 acetyl xylan esterase BL14DL4_02984 ENOG4105E5Q amino acid AbC transporter BL14DL4_02985 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein BL14DL4_02986 ENOG4105NF4 modulator of drug activity BL14DL4_02988 ENOG4105CS2 ec 3.2.1.21 BL14DL4_02991 ENOG4107WDG serine threonine protein kinase BL14DL4_02992 ENOG4105C8Q Methyl-accepting chemotaxis BL14DL4_02993 ENOG4105C8Q Methyl-accepting chemotaxis BL14DL4_02999 ENOG4105F38 ABC transporter, permease BL14DL4_03000 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component BL14DL4_03001 ENOG4105CEY Amp-dependent synthetase and ligase BL14DL4_03005 ENOG4105SX7 Transporter BL14DL4_03007 ENOG4105W8Z 4'-phosphopantetheinyl transferase BL14DL4_03008 ENOG4108SA1 esterase BL14DL4_03009 ENOG41086D8 Transcriptional regulator BL14DL4_03012 ENOG4105CJ1 ABC, transporter BL14DL4_03017 ENOG4105CDA abc transporter atp-binding protein BL14DL4_03018 ENOG4105DRP amino acid AbC transporter BL14DL4_03020 ENOG4108JUB Transcriptional regulator BL14DL4_03021 ENOG4105C8Y Acetylornithine aminotransferase BL14DL4_03022 ENOG4108IQI permease BL14DL4_03023 ENOG41066UZ arginase EC 3.5.3.1 BL14DL4_03024 ENOG4106P55 Transcriptional regulator BL14DL4_03025 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BL14DL4_03026 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BL14DL4_03027 ENOG41069ZX BL14DL4_03028 ENOG41069ZX BL14DL4_03036 ENOG4107EV6 Inherit from COG: YD repeat protein BL14DL4_03040 ENOG4105C2F Histidine kinase BL14DL4_03041 ENOG4105EQD regulatoR BL14DL4_03042 ENOG4105DFW ABC transporter BL14DL4_03044 ENOG4108HWW ABC transporter BL14DL4_03045 ENOG4105DCM major facilitator superfamily BL14DL4_03046 ENOG410645S MarR family Transcriptional regulator BL14DL4_03047 ENOG4105C4C beta-galactosidase BL14DL4_03048 ENOG4107T32 3-phytase (EC 3.1.3.8) BL14DL4_03049 ENOG4105DUX Transporter BL14DL4_03052 ENOG4105E1K spore germination protein BL14DL4_03055 ENOG4107TXC Transcriptional regulator BL14DL4_03057 ENOG4107WD8 ABC transporter, permease BL14DL4_03058 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BL14DL4_03059 ENOG4105BZU Histidine kinase BL14DL4_03060 ENOG4105C8Q Methyl-accepting chemotaxis BL14DL4_03061 ENOG4105CFH Aspartokinase BL14DL4_03062 ENOG4105DHS permease protein BL14DL4_03063 ENOG4105CM4 permease protein BL14DL4_03064 ENOG4108IPW abc transporter atp-binding protein BL14DL4_03067 ENOG4105R8C Transcriptional regulator BL14DL4_03069 ENOG4108DBC nitroreductase BL14DL4_03070 ENOG41067V3 Antibiotic biosynthesis monooxygenase BL14DL4_03071 ENOG4105YVS arsR family transcriptional regulator BL14DL4_03073 ENOG4108JPW Aminotransferase BL14DL4_03074 ENOG4107QTZ amino acid BL14DL4_03075 ENOG4105C26 Dehydrogenase BL14DL4_03076 ENOG4108RNG Permease of the drug metabolite transporter BL14DL4_03078 ENOG4105KTB nuclear export factor GLE1 BL14DL4_03079 ENOG4108T5E Copper resistance protein BL14DL4_03080 ENOG4108ZYE Transcriptional regulator BL14DL4_03082 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BL14DL4_03083 ENOG4108IFG nitrite reductase, (NAD(P)H) BL14DL4_03084 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BL14DL4_03085 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BL14DL4_03086 ENOG4105DRR Transcriptional regulator, GntR family BL14DL4_03087 ENOG4105C8P )-transporter BL14DL4_03090 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia BL14DL4_03094 ENOG4108IUS Transketolase BL14DL4_03096 ENOG4105E7W lamb ycsf family protein BL14DL4_03097 ENOG4105C5A transporter BL14DL4_03098 ENOG4105CFM UPF0317 protein BL14DL4_03099 ENOG4105P4J Allophanate hydrolase, subunit 1 BL14DL4_03101 ENOG4107258 Transcriptional regulator BL14DL4_03102 ENOG4105XJB lipolytic protein G-D-S-L family BL14DL4_03105 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BL14DL4_03106 ENOG4105ETD TRANSCRIPTIONal BL14DL4_03107 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BL14DL4_03110 ENOG410606W general stress protein BL14DL4_03112 ENOG4108RCF TRANSCRIPTIONal BL14DL4_03113 ENOG4105VCH membrane BL14DL4_03116 ENOG4105C9U ATP-dependent DNA helicase RecQ BL14DL4_03117 ENOG4105C0X amino acid BL14DL4_03119 ENOG4108M1A Chitin-binding protein BL14DL4_03122 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BL14DL4_03123 ENOG4107BMA Transglycosylase associated protein BL14DL4_03124 ENOG4108IJ0 Aspartate ammonia-lyase BL14DL4_03125 ENOG41087PP glycosyltransferase MGT family BL14DL4_03126 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BL14DL4_03127 ENOG4105EU9 BL14DL4_03129 ENOG41082W1 Cupin 2, conserved barrel domain protein BL14DL4_03130 ENOG4105QVS general stress protein BL14DL4_03131 ENOG4106F5Q Membrane BL14DL4_03132 ENOG4105CK2 sodium dicarboxylate symporter BL14DL4_03133 ENOG4105CJ1 ABC, transporter BL14DL4_03136 ENOG4105FDT acyl-CoA dehydrogenase BL14DL4_03139 ENOG4105SZ6 Thioredoxin BL14DL4_03140 ENOG4105CPF Cell wall formation (By similarity) BL14DL4_03141 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BL14DL4_03143 ENOG4105C1J atp-dependent rna helicase BL14DL4_03144 ENOG410905X membrane-flanked domain protein BL14DL4_03145 ENOG4105CKV Membrane BL14DL4_03147 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BL14DL4_03148 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BL14DL4_03150 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BL14DL4_03151 ENOG4107MMM Anti-sigma-factor antagonist BL14DL4_03152 ENOG4105FUA antagonist BL14DL4_03153 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BL14DL4_03154 ENOG4107SGM protein serine threonine phosphatase BL14DL4_03158 ENOG41064BQ Phosphatase BL14DL4_03160 ENOG4105ST3 Transcriptional regulator BL14DL4_03161 ENOG4105EYF MMPL domain protein BL14DL4_03171 ENOG4105VZ8 Transcriptional regulator BL14DL4_03173 ENOG4105VEQ Cold shock protein BL14DL4_03174 ENOG4105CPQ Dehydrogenase BL14DL4_03177 ENOG4108U05 Transcriptional regulator BL14DL4_03178 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BL14DL4_03181 ENOG4105KVH Transcriptional regulator BL14DL4_03187 ENOG4107XCH Cyclase family BL14DL4_03188 ENOG4105C85 amino acid BL14DL4_03191 ENOG4105JVQ RNA Polymerase BL14DL4_03192 ENOG4108P49 AntiSigma factor BL14DL4_03193 ENOG4105EXC Acyl-transferase BL14DL4_03194 ENOG4105C2C drug resistance transporter, Bcr CflA BL14DL4_03196 ENOG4108NEV two component transcriptional regulator, LytTR family BL14DL4_03198 ENOG4108Z6X (sortase) family BL14DL4_03199 ENOG4107QNK )-transporter BL14DL4_03207 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BL14DL4_03208 ENOG4105K8N protein family UPF0079, ATPase BL14DL4_03209 ENOG41072GX Peptidase M22 Glycoprotease BL14DL4_03210 ENOG410801F ribosomal-protein-alanine acetyltransferase BL14DL4_03211 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BL14DL4_03212 ENOG4105C5H ABC transporter BL14DL4_03214 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BL14DL4_03215 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BL14DL4_03216 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BL14DL4_03218 ENOG4108TYN CAAX amino terminal protease family protein BL14DL4_03219 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BL14DL4_03220 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BL14DL4_03226 ENOG41073R8 VanW family BL14DL4_03229 ENOG4108RAV Conserved protein BL14DL4_03230 ENOG4108X07 Tetr family transcriptional regulator BL14DL4_03231 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BL14DL4_03233 ENOG4105K78 MarR family Transcriptional regulator BL14DL4_03234 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BL14DL4_03235 ENOG4105EBR Carboxylesterase BL14DL4_03237 ENOG41087YS Phage shock protein A BL14DL4_03238 ENOG4105DQX Zinc finger domain BL14DL4_03239 ENOG4108WV1 Pfam:DUF477 BL14DL4_03242 ENOG4108NGU Transcriptional regulator BL14DL4_03243 ENOG4105N14 lysine exporter protein LysE YggA BL14DL4_03245 ENOG4105CNI cell division protein FtsW BL14DL4_03246 ENOG4105CNI cell division protein FtsW BL14DL4_03250 ENOG4108ZJ4 polysaccharide deacetylase BL14DL4_03251 ENOG4105E5K Alpha-amylase BL14DL4_03252 ENOG4105FKQ transcriptional regulator BL14DL4_03253 ENOG4108IUK alpha amylase, catalytic BL14DL4_03254 ENOG4107FKK extracellular solute-binding protein family 1 BL14DL4_03255 ENOG4105D56 permease protein BL14DL4_03256 ENOG4105EG2 ABC transporter, permease BL14DL4_03259 ENOG4105CG3 alpha amylase, catalytic region BL14DL4_03260 ENOG4107URF beta-phospho-glucomutase BL14DL4_03261 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BL14DL4_03262 ENOG4105GVJ transcriptional regulator BL14DL4_03273 ENOG4108W3Q Transcriptional regulator BL14DL4_03274 ENOG4107STQ Multicopper oxidase BL14DL4_03278 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BL14DL4_03281 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BL14DL4_03282 ENOG4105C7N Xanthine uracil vitamin C permease BL14DL4_03285 ENOG4108U5N UPF0316 protein BL14DL4_03287 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BL14DL4_03288 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BL14DL4_03289 ENOG4105C83 adenylosuccinate lyase BL14DL4_03290 ENOG4105C8V SAICAR synthetase BL14DL4_03291 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BL14DL4_03293 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BL14DL4_03295 ENOG4105CXB phosphoribosylaminoimidazole synthetase BL14DL4_03296 ENOG4108V3E phosphoribosylglycinamide formyltransferase BL14DL4_03297 ENOG4105DC1 bifunctional purine biosynthesis protein purh BL14DL4_03298 ENOG4105C12 Phosphoribosylglycinamide synthetase BL14DL4_03300 ENOG4106A3M Cytochrome p-450 BL14DL4_03306 ENOG4108R5T secreted protein BL14DL4_03307 ENOG4105KGF protein, YerC YecD BL14DL4_03309 ENOG4105C4R Atp-dependent dna helicase BL14DL4_03310 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BL14DL4_03312 ENOG4108M21 BL14DL4_03314 ENOG4105MUZ Protein of unknown function DUF2620 BL14DL4_03315 ENOG4106M0N transport system permease protein BL14DL4_03316 ENOG41080QX K07048 phosphotriesterase-related protein BL14DL4_03317 ENOG4106PKC pyridoxal phosphate binding BL14DL4_03318 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BL14DL4_03319 ENOG4108626 Racemase BL14DL4_03320 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BL14DL4_03321 ENOG4105KT7 mgtC SapB transporter BL14DL4_03322 ENOG4105CK7 Sodium proline symporter BL14DL4_03324 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BL14DL4_03325 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BL14DL4_03326 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BL14DL4_03329 ENOG4105D3P Mannan endo-1,4-beta-mannosidase BL14DL4_03330 ENOG4108IG5 Transcriptional regulator BL14DL4_03333 ENOG4105D9U N-acetyltransferase BL14DL4_03334 ENOG4105DU0 nucleoside hydrolase BL14DL4_03335 ENOG4105CBD Diacylglycerol kinase BL14DL4_03336 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BL14DL4_03340 ENOG4105C5Y PTS System BL14DL4_03341 ENOG4105CS2 ec 3.2.1.21 BL14DL4_03342 ENOG4105CID antiterminator BL14DL4_03343 ENOG410780I phosphoprotein phosphatase activity BL14DL4_03346 ENOG4105CDY transcriptional regulatory protein BL14DL4_03349 ENOG4105C26 Dehydrogenase BL14DL4_03350 ENOG4105FKZ Methyl-accepting chemotaxis BL14DL4_03351 ENOG4105C8P )-transporter BL14DL4_03352 ENOG4105C5H ABC transporter BL14DL4_03353 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) BL14DL4_03354 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase BL14DL4_03356 ENOG4105CKI cobalamin synthesis protein BL14DL4_03357 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) BL14DL4_03358 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BL14DL4_03359 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BL14DL4_03360 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BL14DL4_03361 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BL14DL4_03362 ENOG4106A3M Cytochrome p-450 BL14DL4_03364 ENOG4107SWG transcriptional regulator MERR family BL14DL4_03365 ENOG4105DXB Major Facilitator superfamily BL14DL4_03366 ENOG4105C5H ABC transporter BL14DL4_03367 ENOG4105FDU atp-dependent rna helicase BL14DL4_03368 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BL14DL4_03371 ENOG4107QPK )-transporter BL14DL4_03378 ENOG41082BM Transcriptional regulator, arsr family BL14DL4_03379 ENOG410855V Acylphosphatase BL14DL4_03380 ENOG4108RPX mosc domain containing protein BL14DL4_03383 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BL14DL4_03387 ENOG4105C5Y PTS System BL14DL4_03388 ENOG4105CG3 alpha amylase, catalytic region BL14DL4_03389 ENOG4107414 GntR family transcriptional regulator BL14DL4_03394 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BL14DL4_03395 ENOG4105D7W serine acetyltransferase BL14DL4_03396 ENOG4108IAJ Nad-dependent epimerase dehydratase BL14DL4_03399 ENOG4107TVC Glycosyl transferase, family 2 BL14DL4_03402 ENOG4107QQG Dehydrogenase BL14DL4_03404 ENOG4105KVH Transcriptional regulator BL14DL4_03405 ENOG4108RCM Nitroreductase BL14DL4_03406 ENOG4105CGH 5'-nucleotidase BL14DL4_03407 ENOG4107RKG DJ-1/PfpI family BL14DL4_03409 ENOG4105BZG amino acid carrier protein BL14DL4_03410 ENOG4105KJF protein tyrosine phosphatase BL14DL4_03412 ENOG4107U9T Pfam:Ribonuclease_BN BL14DL4_03414 ENOG4108ISG Major Facilitator BL14DL4_03416 ENOG4105UPD Calcium Proton BL14DL4_03421 ENOG4105DCT glycerol dehydrogenase BL14DL4_03423 ENOG4105D7N magnesium and cobalt transport protein CorA BL14DL4_03425 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BL14DL4_03432 ENOG41079KZ Major Facilitator Superfamily BL14DL4_03436 ENOG4105EVH UPF0753 protein BL14DL4_03437 ENOG4108TWJ NADH dehydrogenase subunit 5 BL14DL4_03438 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BL14DL4_03440 ENOG4107RUY (E1 component), alpha subunit BL14DL4_03442 ENOG4107QKR Dehydrogenase BL14DL4_03444 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BL14DL4_03445 ENOG4105KK4 UPF0060 membrane protein BL14DL4_03446 ENOG4105F8D glycoside hydrolase family 4 BL14DL4_03447 ENOG4108Q3X Transcriptional regulator BL14DL4_03448 ENOG4105CI1 PTS System BL14DL4_03451 ENOG4105KVH Transcriptional regulator BL14DL4_03453 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BL14DL4_03454 ENOG4105E4I Glycoside hydrolase family 28 BL14DL4_03455 ENOG4105DSG hydrolase family 43 BL14DL4_03456 ENOG4106HBX Transcriptional Regulator AraC Family BL14DL4_03458 ENOG4105DYS nad(p)h dehydrogenase (quinone) BL14DL4_03463 ENOG4105JAB phenazine biosynthesis protein, phzf family BL14DL4_03464 ENOG4107Y03 Nitroreductase BL14DL4_03468 ENOG4105ECP epimerase BL14DL4_03469 ENOG410691R Modulates RecA activity (By similarity) BL14DL4_03474 ENOG4105CKK Glycosyl transferase, family 2 BL14DL4_03476 ENOG4105EJV Membrane BL14DL4_03477 ENOG41067AE Membrane-bound metal-dependent hydrolase BL14DL4_03478 ENOG4105CEN a g-specific adenine glycosylase BL14DL4_03479 ENOG4106BXE BL14DL4_03480 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BL14DL4_03484 ENOG4105BZ1 (ABC) transporter BL14DL4_03485 ENOG4105C3U ABC transporter BL14DL4_03486 ENOG4108JQ7 (ABC) transporter BL14DL4_03487 ENOG4105DEF Extracellular solute-binding protein, family 5 BL14DL4_03488 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BL14DL4_03489 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BL14DL4_03490 ENOG4107NBY Membrane BL14DL4_03491 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BL14DL4_03492 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BL14DL4_03493 ENOG4105G5W regulator Fur family BL14DL4_03494 ENOG4105TUA UPF0295 protein BL14DL4_03520 ENOG4107EV6 Inherit from COG: YD repeat protein BL14DL4_03522 ENOG4105C22 threonyL-tRNA synthetase BL14DL4_03523 ENOG4105FF2 Type I DHQase BL14DL4_03524 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BL14DL4_03525 ENOG4105D7T ABC transporter BL14DL4_03526 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BL14DL4_03527 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BL14DL4_03528 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BL14DL4_03529 ENOG4107D63 BL14DL4_03530 ENOG4105VZ8 Transcriptional regulator BL14DL4_03532 ENOG4105DA5 (ABC) transporter BL14DL4_03536 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BL14DL4_03539 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BL14DL4_03541 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BL14DL4_03545 ENOG4105CYN Serine protein kinase BL14DL4_03546 ENOG4106AKX UPF0229 protein BL14DL4_03547 ENOG4105CW7 secretion protein, HlyD family BL14DL4_03548 ENOG4105C0R drug resistance transporter emrb qaca subfamily BL14DL4_03549 ENOG4105CS1 NAD(P)H quinone oxidoreductase BL14DL4_03551 ENOG4105CZV ABC transporter BL14DL4_03552 ENOG4105CJ1 ABC, transporter BL14DL4_03553 ENOG4108TU7 Inherit from COG: (ABC) transporter BL14DL4_03554 ENOG4105VEQ Cold shock protein BL14DL4_03555 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BL14DL4_03556 ENOG4108UMI ABC transporter, permease BL14DL4_03558 ENOG4107R6U sodium dicarboxylate symporter BL14DL4_03564 ENOG4105BZU Histidine kinase BL14DL4_03567 ENOG4108YBP pseudouridine synthase BL14DL4_03569 ENOG41080XP Cbs domain BL14DL4_03570 ENOG4107YBY Hydrolase BL14DL4_03571 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BL14DL4_03573 ENOG4105C5H ABC transporter BL14DL4_03574 ENOG4105TMB Formate nitrite transporter BL14DL4_03575 ENOG4105RK9 auxin efflux carrier BL14DL4_03576 ENOG4105CB2 alcohol dehydrogenase BL14DL4_03577 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BL14DL4_03579 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BL14DL4_03581 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BL14DL4_03585 ENOG4105BZU Histidine kinase BL14DL4_03586 ENOG4105WH1 Two component transcriptional regulator luxr family BL14DL4_03590 ENOG4105KPV Transcriptional regulator BL14DL4_03591 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BL14DL4_03592 ENOG4105ED1 spovr family BL14DL4_03595 ENOG4105BZN citrate synthase BL14DL4_03597 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BL14DL4_03598 ENOG4105C8J )-transporter BL14DL4_03600 ENOG41086D8 Transcriptional regulator BL14DL4_03601 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BL14DL4_03604 ENOG4105J37 BL14DL4_03605 ENOG4108AEY RNA polymerase sigma factor BL14DL4_03606 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BL14DL4_03608 ENOG4105F6E Acyl-transferase BL14DL4_03610 ENOG4105KAF membrAne BL14DL4_03612 ENOG4105U5Y Transcriptional regulator BL14DL4_03613 ENOG4105C37 (CBS) domain BL14DL4_03616 ENOG4105C37 (CBS) domain BL14DL4_03622 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BL14DL4_03624 ENOG4105D64 Mechanosensitive ion channel BL14DL4_03625 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BL14DL4_03627 ENOG4107VMI polysaccharide deacetylase BL14DL4_03628 ENOG4105F0I Aminotransferase BL14DL4_03630 ENOG4108N2V aldose 1-epimerase BL14DL4_03635 ENOG4105BZ1 (ABC) transporter BL14DL4_03636 ENOG4105BZ1 (ABC) transporter BL14DL4_03644 ENOG410839P BL14DL4_03646 ENOG4106MP8 UPF0754 membrane protein BL14DL4_03647 ENOG4105WZB UPF0342 protein BL14DL4_03649 ENOG4105D4P Coproporphyrinogen iii oxidase BL14DL4_03650 ENOG4107S91 Sodium hydrogen exchanger BL14DL4_03651 ENOG4105NCW Trka-c domain protein BL14DL4_03653 ENOG4105CGU Enoyl-CoA hydratase BL14DL4_03658 ENOG4108IUX (ABC) transporter BL14DL4_03659 ENOG4105RHA ABC transporter, permease BL14DL4_03660 ENOG4107VRP DNA repair exonuclease BL14DL4_03661 ENOG4106D4I domain protein BL14DL4_03662 ENOG4105EQI Metal Dependent Phosphohydrolase BL14DL4_03664 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BL14DL4_03671 ENOG4105NBU tryptophan transport protein BL14DL4_03672 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BL14DL4_03673 ENOG4105K59 histidine triad (HIT) protein BL14DL4_03679 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BL14DL4_03680 ENOG4105BZ4 penicillin-binding protein BL14DL4_03681 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BL14DL4_03682 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BL14DL4_03683 ENOG4105C1Q protoporphyrinogen oxidase BL14DL4_03685 ENOG4105ECB domain protein BL14DL4_03687 ENOG4105DER m42 family BL14DL4_03690 ENOG4106AXD BL14DL4_03691 ENOG4108RQ5 Beta-lactamase domain-containing protein BL14DL4_03692 ENOG4105DF9 Lipoate-protein, ligase BL14DL4_03693 ENOG4105CEY Amp-dependent synthetase and ligase BL14DL4_03695 ENOG4108JCI Transcriptional regulator BL14DL4_03698 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BL14DL4_03699 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BL14DL4_03700 ENOG4108UZ3 Transporter BL14DL4_03701 ENOG4108HUF Transporter BL14DL4_03702 ENOG4105DQ5 transport system permease protein BL14DL4_03703 ENOG4108U1V ABC transporter, permease BL14DL4_03704 ENOG4107TB6 phosphoglycerate mutase BL14DL4_03705 ENOG4106YBV Methyl-accepting chemotaxis BL14DL4_03709 ENOG4105XVF Competence transcription factor BL14DL4_03710 ENOG41060YP BL14DL4_03713 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BL14DL4_03715 ENOG4105G9B Transcriptional regulator BL14DL4_03717 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) BL14DL4_03719 ENOG4105S0E allantoin catabolism protein BL14DL4_03720 ENOG4105DG4 malate L-lactate dehydrogenase BL14DL4_03721 ENOG4105DG4 malate L-lactate dehydrogenase BL14DL4_03722 ENOG4107R1Q Membrane protein FdrA BL14DL4_03723 ENOG4107REC cytoplasmic protein BL14DL4_03725 ENOG4105C5B carbamate kinase BL14DL4_03726 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) BL14DL4_03727 ENOG410780I phosphoprotein phosphatase activity BL14DL4_03733 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BL14DL4_03734 ENOG4105I1K ABC transporter BL14DL4_03736 ENOG4108KK1 membrane protein AbrB duplication BL14DL4_03739 ENOG4105WEF catalase BL14DL4_03740 ENOG4105CEY Amp-dependent synthetase and ligase BL14DL4_03741 ENOG4106K7D Major facilitator family transporter BL14DL4_03743 ENOG4105BZU Histidine kinase BL14DL4_03744 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BL14DL4_03746 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BL14DL4_03747 ENOG4105E0C molybdate abc transporter BL14DL4_03749 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BL14DL4_03751 ENOG4105EYH Exonuclease BL14DL4_03758 ENOG410751J BL14DL4_03762 ENOG4105ERH Fumarylacetoacetate hydrolase BL14DL4_03767 ENOG4105CAQ asparagine synthetase BL14DL4_03769 ENOG4108YZA Nitrogen regulatory protein pii BL14DL4_03770 ENOG4105UQX Mate efflux family protein BL14DL4_03771 ENOG4106HBX Transcriptional Regulator AraC Family BL14DL4_03773 ENOG4105ETE Transcriptional regulator (LacI family BL14DL4_03774 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BL14DL4_03778 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BL14DL4_03779 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BL14DL4_03781 ENOG4105DY8 decarboxylase BL14DL4_03786 ENOG4105MA6 gCN5-related N-acetyltransferase BL14DL4_03787 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BL14DL4_03788 ENOG4105D29 Helix-turn-helix type 11 domain protein BL14DL4_03791 ENOG4108VPT UPF0234 protein BL14DL4_03792 ENOG4105QNR S1 RNA binding domain protein BL14DL4_03795 ENOG4105EPR degv family BL14DL4_03796 ENOG4107AYK membrAne BL14DL4_03798 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BL14DL4_03799 ENOG41073B9 BL14DL4_03800 ENOG4108KP7 hydrolase BL14DL4_03801 ENOG4108MXZ Esterase BL14DL4_03802 ENOG4105VG1 fes assembly suf system protein BL14DL4_03803 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BL14DL4_03804 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BL14DL4_03805 ENOG4105CAS nag kinase BL14DL4_03806 ENOG4105C8Y Acetylornithine aminotransferase BL14DL4_03807 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BL14DL4_03809 ENOG4105DBV ornithine carbamoyltransferase BL14DL4_03810 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BL14DL4_03815 ENOG4107RMD Basic membrane lipoprotein BL14DL4_03818 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BL14DL4_03819 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BL14DL4_03821 ENOG4105C3U ABC transporter BL14DL4_03822 ENOG4108JQ7 (ABC) transporter BL14DL4_03825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BL14DL4_03830 ENOG4105C31 Tryptophanyl-tRNA synthetase BL14DL4_03831 ENOG4108J59 Extracellular solute-binding protein, family 5 BL14DL4_03832 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BL14DL4_03833 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BL14DL4_03835 ENOG4108JQ7 (ABC) transporter BL14DL4_03837 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BL14DL4_03838 ENOG4108ZCF integral membrane protein BL14DL4_03839 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BL14DL4_03843 ENOG4108V9W transcriptional regulatory protein BL14DL4_03844 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BL14DL4_03846 ENOG4105DPN Oligoendopeptidase f BL14DL4_03848 ENOG4105T58 Dithiol-disulfide isomerase BL14DL4_03849 ENOG4108Z18 K06886 hemoglobin BL14DL4_03850 ENOG4105E4C Lytic transglycosylase catalytic BL14DL4_03851 ENOG4105MIX Adenylate cyclase BL14DL4_03852 ENOG4106EFP UPF0738 protein BL14DL4_03854 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BL14DL4_03855 ENOG4105EMS pseudouridine synthase BL14DL4_03856 ENOG4107S1Q Phosphatase BL14DL4_03858 ENOG4105ETU transcriptional activator (TenA BL14DL4_03859 ENOG4108VEU Thiamine monophosphate synthase BL14DL4_03862 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BL14DL4_03863 ENOG4105D06 uba thif-type nad fad binding protein BL14DL4_03864 ENOG4105DWF phosphomethylpyrimidine kinase BL14DL4_03865 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BL14DL4_03866 ENOG4107A88 BL14DL4_03876 ENOG4105ENA helicase BL14DL4_03878 ENOG4107T5V SNARE associated Golgi BL14DL4_03879 ENOG4105CMR udp-glucose 4-epimerase BL14DL4_03880 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BL14DL4_03883 ENOG4108ZMI UPF0477 protein BL14DL4_03887 ENOG4105C28 cystathionine BL14DL4_03888 ENOG4105C28 cystathionine BL14DL4_03889 ENOG4105JHY Membrane BL14DL4_03893 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase BL14DL4_03896 ENOG4108UW5 maltose o-acetyltransferase BL14DL4_03898 ENOG4105DUM transcriptional regulator, lysR family BL14DL4_03899 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BL14DL4_03900 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BL14DL4_03902 ENOG4108Q5Y Membrane BL14DL4_03903 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BL14DL4_03905 ENOG41069ER domain protein BL14DL4_03906 ENOG4105C0R drug resistance transporter emrb qaca subfamily BL14DL4_03907 ENOG4105J7D transcriptional regulator BL14DL4_03912 ENOG4105K7W phage-related replication protein BL14DL4_03913 ENOG410635T phage-like element pbsx protein BL14DL4_03923 ENOG4108TFU terminase (Small subunit) BL14DL4_03924 ENOG4105IG6 Phage terminase, large subunit BL14DL4_03925 ENOG4108MDF Phage Portal Protein BL14DL4_03930 ENOG41060SN BL14DL4_03933 ENOG4105PQS phage protein BL14DL4_03934 ENOG4105FR7 XkdM protein, phage-like element PBSX BL14DL4_03935 ENOG4105MTC XkdN-like protein BL14DL4_03936 ENOG4108FKH Transglycosylase SLT domain BL14DL4_03937 ENOG4108WZM domain protein BL14DL4_03938 ENOG4105X7F BL14DL4_03940 ENOG4105MFU Protein of unknown function (DUF2634) BL14DL4_03941 ENOG41066EA baseplate J family protein BL14DL4_03944 ENOG41068G1 BL14DL4_03945 ENOG41068G1 BL14DL4_03948 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BL14DL4_03949 ENOG4107XBN GntR Family Transcriptional Regulator BL14DL4_03950 ENOG4105CPQ Dehydrogenase BL14DL4_03951 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BL14DL4_03952 ENOG4105DMW Dehydrogenase reductase BL14DL4_03953 ENOG4105CPQ Dehydrogenase BL14DL4_03954 ENOG4108I5G Major Facilitator superfamily BL14DL4_03957 ENOG4105CJ3 phosphate transporter BL14DL4_03958 ENOG4107GRR phosphate transport regulator BL14DL4_03959 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BL14DL4_03961 ENOG4105C2F Histidine kinase BL14DL4_03962 ENOG4105EQD regulatoR BL14DL4_03963 ENOG410769Z extracellular solute-binding protein family 1 BL14DL4_03964 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BL14DL4_03965 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component BL14DL4_03966 ENOG4105F5H Glycosyl Hydrolase Family 88 BL14DL4_03967 ENOG41075H3 AraC family transcriptional regulator BL14DL4_03968 ENOG4107TDE lipolytic protein G-D-S-L family BL14DL4_03971 ENOG4105CX8 fg-gap repeat protein BL14DL4_03973 ENOG4107TDE lipolytic protein G-D-S-L family BL14DL4_03974 ENOG4105CX8 fg-gap repeat protein BL14DL4_03975 ENOG4105CPC Aldo Keto reductase BL14DL4_03976 ENOG4107TDE lipolytic protein G-D-S-L family BL14DL4_03978 ENOG4105EKC BL14DL4_03979 ENOG4105E0S extracellular solute-binding protein family 1 BL14DL4_03981 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BL14DL4_03982 ENOG4107R7I amino acid BL14DL4_03985 ENOG4105C0H protease BL14DL4_03987 ENOG4108ME1 Peptidase M55 D-aminopeptidase BL14DL4_03988 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BL14DL4_03989 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BL14DL4_03990 ENOG4105C3U ABC transporter BL14DL4_03992 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BL14DL4_03993 ENOG4105DTQ mandelate racemase muconate lactonizing BL14DL4_03994 ENOG4107SN7 NLP P60 protein BL14DL4_03995 ENOG4108JQ7 (ABC) transporter BL14DL4_03996 ENOG4107TUM Amidinotransferase BL14DL4_03997 ENOG4108S4H thioesterase Superfamily protein BL14DL4_04004 ENOG410839T multidrug resistance protein BL14DL4_04005 ENOG41080TC multidrug resistance protein BL14DL4_04006 ENOG4105CIY formyltetrahydrofolate deformylase BL14DL4_04007 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BL14DL4_04008 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BL14DL4_04010 ENOG4105K56 Transcriptional regulator BL14DL4_04011 ENOG4108ZHJ Organic hydroperoxide resistance protein BL14DL4_04013 ENOG4107Y2X deaminase BL14DL4_04014 ENOG4105CVJ phosphoglycerate mutase BL14DL4_04017 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BL14DL4_04018 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BL14DL4_04020 ENOG4105CJW magnesium transporter BL14DL4_04022 ENOG4105V75 Transcriptional regulator BL14DL4_04027 ENOG4105DQE DNA ligase BL14DL4_04028 ENOG4105FDF Could be involved in DNA repair (By similarity) BL14DL4_04029 ENOG4105BZU Histidine kinase BL14DL4_04030 ENOG4107T5V SNARE associated Golgi BL14DL4_04031 ENOG4107TS3 membrane protein, TerC BL14DL4_04032 ENOG4108WZW RNA polymerase sigma BL14DL4_04034 ENOG410681C small acid-soluble spore protein BL14DL4_04036 ENOG4105D0M Protease HtpX homolog BL14DL4_04038 ENOG4107RVG penicillin-binding protein BL14DL4_04041 ENOG4108TGC Acyltransferase BL14DL4_04042 ENOG4105BZU Histidine kinase BL14DL4_04043 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BL14DL4_04045 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BL14DL4_04047 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BL14DL4_04049 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BL14DL4_04051 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BL14DL4_04052 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BL14DL4_04055 ENOG4105BZU Histidine kinase BL14DL4_04056 ENOG41090MY MarR family Transcriptional regulator BL14DL4_04057 ENOG4105ER2 Ompa motb domain protein BL14DL4_04058 ENOG4105E14 MotA TolQ exbB proton channel BL14DL4_04060 ENOG4108K88 Membrane BL14DL4_04061 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BL14DL4_04062 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BL14DL4_04063 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BL14DL4_04064 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BL14DL4_04069 ENOG4105NX3 Membrane BL14DL4_04070 ENOG4105VMP Transcriptional regulator BL14DL4_04078 ENOG4105F0V Cell wall hydrolase BL14DL4_04081 ENOG4105C59 p-type ATPase BL14DL4_04082 ENOG4105DC7 peptidase M24 BL14DL4_04086 ENOG4105CID antiterminator BL14DL4_04088 ENOG4105KRI phosphocarrier protein (HPr BL14DL4_04089 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BL14DL4_04091 ENOG4105F6S Spore photoproduct lyase BL14DL4_04093 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BL14DL4_04094 ENOG4105CHR reductase BL14DL4_04095 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BL14DL4_04096 ENOG4105K4I Scp-like extracellular BL14DL4_04098 ENOG4105BZU Histidine kinase BL14DL4_04099 ENOG4105CHM Aminotransferase BL14DL4_04103 ENOG4107R88 Chemotaxis protein (CheV) BL14DL4_04104 ENOG4105UIN BL14DL4_04106 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein BL14DL4_04108 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BL14DL4_04109 ENOG4105EPM Diguanylate phosphodiesterase BL14DL4_04111 ENOG4107IN1 Protein of unknown function (DUF1797) BL14DL4_04113 ENOG4108XRC Protein of unknown function (DUF458) BL14DL4_04119 ENOG4105NQC Flavodoxin BL14DL4_04120 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BL14DL4_04123 ENOG4105D3R alkyl hydroperoxide reductase BL14DL4_04124 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BL14DL4_04127 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BL14DL4_04128 ENOG4105D06 uba thif-type nad fad binding protein BL14DL4_04129 ENOG4105CVM Molybdenum cofactor synthesis domain protein BL14DL4_04130 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BL14DL4_04131 ENOG4108ZAF Molybdopterin BL14DL4_04132 ENOG41067WU Molybdopterin converting factor (Subunit 1) BL14DL4_04134 ENOG4105BZ1 (ABC) transporter BL14DL4_04135 ENOG4105BZ1 (ABC) transporter BL14DL4_04137 ENOG4107X8C Efflux transporter RND family MFP subunit BL14DL4_04138 ENOG4105C19 ABC transporter BL14DL4_04139 ENOG4107RBB ABC transporter, permease BL14DL4_04140 ENOG4105E98 transcriptional regulator DeoR family BL14DL4_04141 ENOG4105DE4 1-phosphofructokinase BL14DL4_04142 ENOG4105DM4 PTS System BL14DL4_04143 ENOG4105C3F Signal peptidase i BL14DL4_04146 ENOG4105C5H ABC transporter BL14DL4_04152 ENOG4105BZU Histidine kinase BL14DL4_04153 ENOG4107ZYR domain protein BL14DL4_04155 ENOG4105CN5 Metallo-Beta-Lactamase BL14DL4_04157 ENOG4108X4Q Hydrolase BL14DL4_04159 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BL14DL4_04163 ENOG4105CPP Dehydrogenase, E1 component BL14DL4_04164 ENOG4105C7S Dehydrogenase BL14DL4_04165 ENOG4107QN2 dihydrolipoyl dehydrogenase BL14DL4_04169 ENOG4105CXN decarboxylase BL14DL4_04170 ENOG4105WBI UPF0223 protein BL14DL4_04173 ENOG4105ECY inositol monophosphatase BL14DL4_04180 ENOG4105CI3 gtp-binding protein typa BL14DL4_04181 ENOG4105QA2 BL14DL4_04182 ENOG4108INS Transcriptional regulator BL14DL4_04183 ENOG4107SCK Monooxygenase BL14DL4_04186 ENOG4108IAB Phoh family BL14DL4_04188 ENOG4105CSV Glutaminase BL14DL4_04189 ENOG4105ZPI UPF0358 protein BL14DL4_04190 ENOG4105CNI cell division protein FtsW BL14DL4_04191 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BL14DL4_04193 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BL14DL4_04195 ENOG4105BZ9 Cytochrome C oxidase, subunit I BL14DL4_04196 ENOG4105CCU oxidase (Subunit III) BL14DL4_04197 ENOG41064X9 cytochrome C oxidase subunit IV BL14DL4_04200 ENOG41080XQ Signal transduction protein with cbs domains BL14DL4_04201 ENOG4106UY4 Inherit from COG: Scp-like extracellular BL14DL4_04207 ENOG4106H78 methyltransferase BL14DL4_04208 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BL14DL4_04209 ENOG4105H20 Sporulation integral membrane protein YlbJ BL14DL4_04210 ENOG41063PX domain protein BL14DL4_04211 ENOG4105CDE UPF0348 protein BL14DL4_04212 ENOG4105KNH Nucleic acid-binding protein BL14DL4_04213 ENOG41067VY 50S ribosomal protein L32 BL14DL4_04217 ENOG41074B2 UPF0747 protein BL14DL4_04218 ENOG4108V6E Cell division protein mraZ BL14DL4_04219 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BL14DL4_04221 ENOG4105CJN penicillin-binding protein BL14DL4_04222 ENOG4105CJN penicillin-binding protein BL14DL4_04224 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BL14DL4_04225 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BL14DL4_04226 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BL14DL4_04227 ENOG4105CNI cell division protein FtsW BL14DL4_04228 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BL14DL4_04229 ENOG4105D4A Cell wall formation (By similarity) BL14DL4_04230 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BL14DL4_04231 ENOG4108R2U division initiation protein BL14DL4_04233 ENOG4105K67 small basic protein BL14DL4_04234 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BL14DL4_04235 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BL14DL4_04238 ENOG4105FFI sigma-e processing peptidase spoiiga BL14DL4_04239 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BL14DL4_04241 ENOG4105DKW ABC transporter BL14DL4_04242 ENOG4105DHI Methyltransferase BL14DL4_04243 ENOG4105WR5 sporulation protein, YlmC YmxH family BL14DL4_04244 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BL14DL4_04245 ENOG4105DFA alanine racemase domain protein BL14DL4_04246 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BL14DL4_04247 ENOG41067XK integral membrane protein BL14DL4_04248 ENOG4105DBK s4 domain protein BL14DL4_04252 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BL14DL4_04253 ENOG4105C34 Pseudouridine synthase BL14DL4_04254 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BL14DL4_04256 ENOG4105CXT aspartate transcarbamylase BL14DL4_04257 ENOG4105CD3 dihydroorotase BL14DL4_04258 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BL14DL4_04259 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BL14DL4_04260 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BL14DL4_04261 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BL14DL4_04262 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BL14DL4_04265 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BL14DL4_04269 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BL14DL4_04270 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BL14DL4_04271 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BL14DL4_04272 ENOG4105F23 Fibronectin-binding protein BL14DL4_04274 ENOG4105DSJ YicC domain protein BL14DL4_04275 ENOG4105KC4 UPF0296 protein BL14DL4_04276 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BL14DL4_04277 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BL14DL4_04278 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BL14DL4_04279 ENOG4105C25 Primosomal protein n' BL14DL4_04280 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BL14DL4_04281 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BL14DL4_04282 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BL14DL4_04283 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BL14DL4_04284 ENOG4108ZF3 Phosphatase BL14DL4_04285 ENOG4105D9P serine threonine protein kinase BL14DL4_04286 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BL14DL4_04287 ENOG4105DJV ribulose-phosphate 3-epimerase BL14DL4_04288 ENOG4105FJ0 thiamine BL14DL4_04289 ENOG4105VB9 50S ribosomal protein l28 BL14DL4_04290 ENOG4108ZAA Alkaline-shock protein BL14DL4_04291 ENOG4105DP4 dak2 domain fusion protein ylov BL14DL4_04293 ENOG4105EJQ L-serine dehydratase BL14DL4_04294 ENOG4105CB5 ATP-dependent DNA helicase recG BL14DL4_04295 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BL14DL4_04296 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BL14DL4_04297 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BL14DL4_04298 ENOG4105CHR reductase BL14DL4_04299 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BL14DL4_04300 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BL14DL4_04301 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BL14DL4_04302 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BL14DL4_04303 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BL14DL4_04305 ENOG4105K5M 30s ribosomal protein S16 BL14DL4_04306 ENOG4108BW8 UPF0109 protein BL14DL4_04308 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BL14DL4_04309 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BL14DL4_04310 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BL14DL4_04311 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BL14DL4_04312 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BL14DL4_04314 ENOG4105VM1 flagellar BL14DL4_04315 ENOG4105CMV Succinyl-CoA synthetase subunit beta BL14DL4_04316 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BL14DL4_04317 ENOG4105C79 DNA protecting protein DprA BL14DL4_04318 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BL14DL4_04319 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BL14DL4_04320 ENOG4108HE4 integrase family BL14DL4_04321 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BL14DL4_04322 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BL14DL4_04323 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) BL14DL4_04325 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BL14DL4_04326 ENOG4108ZC9 flagellar basal-body rod protein flgc BL14DL4_04327 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BL14DL4_04328 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BL14DL4_04329 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BL14DL4_04332 ENOG4106YF4 Flagellar biosynthesis chaperone BL14DL4_04334 ENOG410696Y Flagellar hook-length control protein BL14DL4_04335 ENOG410822I Flagellar hook capping protein BL14DL4_04336 ENOG4108JQA flagellar BL14DL4_04338 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BL14DL4_04339 ENOG4105DD5 Flagellar motor switch protein BL14DL4_04340 ENOG4107YTP response regulator receiver protein BL14DL4_04342 ENOG4105CN7 Flagellar biosynthetic protein FliP BL14DL4_04343 ENOG4105VS8 Flagellar biosynthetic protein fliq BL14DL4_04344 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BL14DL4_04345 ENOG4105D00 flagellar biosynthetic protein flhB BL14DL4_04346 ENOG4105D7B Flagellar biosynthesis protein flha BL14DL4_04347 ENOG4105FZW flagellar biosynthesis regulator FlhF BL14DL4_04349 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BL14DL4_04350 ENOG4105CBS Chea signal transduction histidine kinase BL14DL4_04351 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BL14DL4_04353 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BL14DL4_04354 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BL14DL4_04356 ENOG4105CE9 30S ribosomal protein S2 BL14DL4_04357 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BL14DL4_04359 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BL14DL4_04360 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BL14DL4_04361 ENOG4105KNE Phosphatidate cytidylyltransferase BL14DL4_04363 ENOG4105DZP Membrane-associated zinc metalloprotease BL14DL4_04365 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BL14DL4_04367 ENOG4105CYP glycoside hydrolase, family BL14DL4_04370 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BL14DL4_04371 ENOG4105CHV Transcription elongation factor NusA BL14DL4_04372 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BL14DL4_04373 ENOG4105VHM ribosomal protein BL14DL4_04374 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BL14DL4_04375 ENOG4105W7A Protein of unknown function (DUF503) BL14DL4_04376 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BL14DL4_04377 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BL14DL4_04378 ENOG4105DTN riboflavin biosynthesis protein ribF BL14DL4_04379 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BL14DL4_04380 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BL14DL4_04382 ENOG4105C1V Peptidase, M16 BL14DL4_04384 ENOG4105E35 Dipicolinate synthase subunit A BL14DL4_04385 ENOG4108S0H Dipicolinic acid synthetase, b subunit BL14DL4_04386 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BL14DL4_04388 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BL14DL4_04390 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BL14DL4_04392 ENOG4105CNU cell division protein FtsK BL14DL4_04393 ENOG4105FDP GntR family transcriptional regulator BL14DL4_04397 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BL14DL4_04398 ENOG4105XZV Protein of unknown function (DUF3243) BL14DL4_04401 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BL14DL4_04402 ENOG4105CEV competence damage-inducible protein BL14DL4_04403 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BL14DL4_04405 ENOG4105D48 metallophosphoesterase BL14DL4_04406 ENOG4105MCT stage V sporulation protein S BL14DL4_04407 ENOG4108IGT Dipeptidase BL14DL4_04408 ENOG4105CPQ Dehydrogenase BL14DL4_04409 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BL14DL4_04410 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BL14DL4_04413 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BL14DL4_04414 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BL14DL4_04416 ENOG4107EV6 Inherit from COG: YD repeat protein BL14DL4_04419 ENOG4105CKI cobalamin synthesis protein BL14DL4_04421 ENOG4107TCE N-acetyltransferase BL14DL4_04425 ENOG4105XPP Protein of unknown function (DUF1275) BL14DL4_04426 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) BL14DL4_04428 ENOG4105U6C Alpha beta hydrolase fold protein BL14DL4_04429 ENOG4105U6C Alpha beta hydrolase fold protein BL14DL4_04431 ENOG41080BT SNARE associated Golgi BL14DL4_04432 ENOG4105FQP Beta-lactamase BL14DL4_04433 ENOG41087PP glycosyltransferase MGT family BL14DL4_04434 ENOG4107QTZ amino acid BL14DL4_04437 ENOG4105VRS hydrolase family 18 BL14DL4_04438 ENOG4105M4P Tetr family transcriptional regulator BL14DL4_04439 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein BL14DL4_04440 ENOG4107S9F NmrA family BL14DL4_04442 ENOG4108X3M OsmC Ohr family protein BL14DL4_04443 ENOG4107E54 Small Multidrug Resistance protein BL14DL4_04447 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BL14DL4_04448 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BL14DL4_04450 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BL14DL4_04451 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL14DL4_04452 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL14DL4_04453 ENOG4105U6W MutT NUDIX family protein BL14DL4_04455 ENOG4108UNV SUF system FeS assembly protein, NifU family BL14DL4_04456 ENOG4105G5W regulator Fur family BL14DL4_04457 ENOG4105DRR Transcriptional regulator, GntR family BL14DL4_04464 ENOG4105PF9 Transcriptional regulator BL14DL4_04475 ENOG4106F1P AAA ATPase, central domain protein BL14DL4_04479 ENOG4107EV6 Inherit from COG: YD repeat protein BL14DL4_04480 ENOG4106ANW SMI1_KNR4 BL14DL4_04481 ENOG4106ANW SMI1_KNR4 BL14DL4_04490 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BL14DL4_04491 ENOG41067D4 cell wall surface anchor family protein