locus-tag	class	description
CD200_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CD200_00010	COG0592	DNA-directed DNA polymerase activity
CD200_00015	COG2501	S4 domain
CD200_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CD200_00030	COG0187	DNA topoisomerase II activity
CD200_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CD200_00070	COG0516	GMP reductase activity
CD200_00070	COG0517	IMP dehydrogenase activity
CD200_00075	COG1686	Belongs to the peptidase S11 family
CD200_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CD200_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CD200_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CD200_00095	COG1929	Belongs to the glycerate kinase type-1 family
CD200_00100	COG2610	gluconate transmembrane transporter activity
CD200_00105	COG3835	regulator
CD200_00120	COG1428	Deoxynucleoside kinase
CD200_00125	COG1428	Deoxynucleoside kinase
CD200_00130	COG1388	LysM domain
CD200_00130	COG3858	chitin binding
CD200_00135	COG1335	isochorismatase
CD200_00140	COG0590	tRNA wobble adenosine to inosine editing
CD200_00150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CD200_00155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CD200_00160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CD200_00205	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
CD200_00210	COG3853	Toxic anion resistance protein (TelA)
CD200_00215	COG1982	Orn Lys Arg decarboxylase major
CD200_00220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CD200_00225	COG3870	Protein conserved in bacteria
CD200_00230	COG1728	Protein conserved in bacteria
CD200_00235	COG0470	DNA polymerase III
CD200_00240	COG1774	PSP1 C-terminal conserved region
CD200_00245	COG4467	Involved in initiation control of chromosome replication
CD200_00250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CD200_00255	COG2827	Endonuclease containing a URI domain
CD200_00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CD200_00265	COG2002	toxin-antitoxin pair type II binding
CD200_00270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CD200_00270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CD200_00275	COG0084	hydrolase, TatD family'
CD200_00280	COG3583	domain protein
CD200_00280	COG3584	3D domain protein
CD200_00285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CD200_00290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CD200_00300	COG4466	Protein conserved in bacteria
CD200_00310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CD200_00315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CD200_00320	COG0251	oxidation-reduction process
CD200_00325	COG2088	sporulation resulting in formation of a cellular spore
CD200_00330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CD200_00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CD200_00340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CD200_00345	COG0193	aminoacyl-tRNA hydrolase activity
CD200_00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CD200_00360	COG2002	toxin-antitoxin pair type II binding
CD200_00365	COG2244	polysaccharide biosynthetic process
CD200_00370	COG3956	TIGRFAM MazG family protein
CD200_00375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CD200_00390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CD200_00395	COG1098	S1 RNA binding domain
CD200_00410	COG2208	phosphoserine phosphatase activity
CD200_00415	COG2304	oxidoreductase activity
CD200_00420	COG0515	serine threonine protein kinase
CD200_00425	COG0037	tRNA processing
CD200_00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CD200_00440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CD200_00445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CD200_00450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CD200_00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CD200_00465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CD200_00470	COG0512	Glutamine amidotransferase of anthranilate synthase
CD200_00475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CD200_00480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CD200_00485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CD200_00490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CD200_00495	COG1396	sequence-specific DNA binding
CD200_00500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CD200_00505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CD200_00585	COG4463	regulation of RNA biosynthetic process
CD200_00590	COG3880	PFAM UvrB UvrC protein
CD200_00595	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CD200_00600	COG0542	response to heat
CD200_00605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CD200_00610	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CD200_00615	COG4956	integral membrane protein (PIN domain superfamily)
CD200_00620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CD200_00625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CD200_00630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CD200_00635	COG1045	serine acetyltransferase
CD200_00640	COG0215	cysteine-tRNA ligase activity
CD200_00645	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CD200_00650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CD200_00655	COG3688	RNA-binding protein containing a PIN domain
CD200_00665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CD200_00675	COG0250	Participates in transcription elongation, termination and antitermination
CD200_00680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CD200_00685	COG0081	regulation of translation
CD200_00690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CD200_00695	COG0222	ribosome binding
CD200_00700	COG2813	Specifically methylates the guanine in position
CD200_00705	COG0085	RNA polymerase activity
CD200_00710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CD200_00715	COG1358	cellular component organization or biogenesis
CD200_00720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CD200_00725	COG0049	tRNA binding
CD200_00730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CD200_00735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CD200_00740	COG0051	transcription antitermination factor activity, RNA binding
CD200_00745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CD200_00750	COG0088	Forms part of the polypeptide exit tunnel
CD200_00755	COG0089	rRNA binding
CD200_00760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CD200_00765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CD200_00770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CD200_00775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CD200_00780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CD200_00785	COG0255	Belongs to the universal ribosomal protein uL29 family
CD200_00790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CD200_00795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CD200_00800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CD200_00805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CD200_00810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CD200_00815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CD200_00820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CD200_00825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CD200_00830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CD200_00835	COG1841	ribosomal large subunit assembly
CD200_00840	COG0200	Binds to the 23S rRNA
CD200_00845	COG0201	protein transport
CD200_00850	COG0563	adenylate kinase activity
CD200_00855	COG0024	Methionine aminopeptidase
CD200_00860	COG2163	COG2163 Ribosomal protein L14E L6E L27E
CD200_00865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CD200_00870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CD200_00875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CD200_00880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CD200_00885	COG0202	RNA polymerase activity
CD200_00890	COG0203	ribosomal protein L17
CD200_00895	COG1122	ATPase activity
CD200_00900	COG1122	ATPase activity
CD200_00905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CD200_00910	COG0101	tRNA pseudouridine synthase activity
CD200_00915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CD200_00920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CD200_00925	COG2318	DinB family
CD200_00935	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD200_00940	COG0489	protein tyrosine kinase activity
CD200_00950	COG2194	sulfuric ester hydrolase activity
CD200_00955	COG0726	polysaccharide deacetylase
CD200_00985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CD200_00995	COG0385	Bile acid
CD200_01010	COG3876	Protein conserved in bacteria
CD200_01015	COG1472	Belongs to the glycosyl hydrolase 3 family
CD200_01020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CD200_01025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_01025	COG1263	PTS System
CD200_01030	COG1737	Transcriptional regulator
CD200_01035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CD200_01040	COG1683	Conserved Protein
CD200_01075	COG1595	DNA-templated transcription, initiation
CD200_01080	COG5662	AntiSigma factor
CD200_01085	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CD200_01090	COG4856	YbbR-like protein
CD200_01095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CD200_01100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CD200_01120	COG1725	Transcriptional regulator
CD200_01125	COG0640	Transcriptional regulator
CD200_01130	COG2814	Major facilitator Superfamily
CD200_01140	COG1132	(ABC) transporter
CD200_01145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CD200_01170	COG1011	Hydrolase
CD200_01175	COG1113	amino acid transport
CD200_01180	COG2851	Citrate transporter
CD200_01185	COG3181	Tripartite tricarboxylate transporter family receptor
CD200_01190	COG4565	transcriptional regulatory protein
CD200_01195	COG3290	protein histidine kinase activity
CD200_01210	COG2211	Major facilitator Superfamily
CD200_01230	COG1331	Highly conserved protein containing a thioredoxin domain
CD200_01235	COG3677	Transposase
CD200_01275	COG1331	Highly conserved protein containing a thioredoxin domain
CD200_01285	COG0477	Major facilitator Superfamily
CD200_01305	COG1283	sodium-dependent phosphate transmembrane transporter activity
CD200_01310	COG4682	membrane
CD200_01335	COG0697	spore germination
CD200_01340	COG2207	Transcriptional regulator
CD200_01340	COG1917	Cupin 2, conserved barrel domain protein
CD200_01360	COG0371	Dehydrogenase
CD200_01365	COG0840	transmembrane signaling receptor activity
CD200_01370	COG4213	ABC transporter substrate-binding protein
CD200_01385	COG4257	antibiotic catabolic process
CD200_01395	COG0833	amino acid
CD200_01400	COG2040	homocysteine
CD200_01410	COG2190	(PTS) system
CD200_01410	COG1263	PTS System
CD200_01410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_01415	COG0789	Transcriptional regulator
CD200_01420	COG2323	membrane
CD200_01435	COG2205	protein histidine kinase activity
CD200_01440	COG1115	amino acid carrier protein
CD200_01445	COG2066	Belongs to the glutaminase family
CD200_01450	COG4191	Histidine kinase
CD200_01455	COG0784	Response regulator, receiver
CD200_01480	COG3540	Alkaline phosphatase
CD200_01485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CD200_01490	COG0805	protein transport
CD200_01495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD200_01500	COG1012	belongs to the aldehyde dehydrogenase family
CD200_01505	COG2271	Major facilitator Superfamily
CD200_01510	COG4948	Mandelate Racemase Muconate Lactonizing
CD200_01515	COG2186	Transcriptional regulator
CD200_01520	COG2721	sulfolactate sulfo-lyase activity
CD200_01525	COG0745	RESPONSE REGULATOR receiver
CD200_01530	COG2205	protein histidine kinase activity
CD200_01535	COG1131	(ABC) transporter
CD200_01560	COG3173	Aminoglycoside phosphotransferase
CD200_01565	COG1846	Transcriptional regulator
CD200_01570	COG0318	PFAM AMP-dependent synthetase and ligase
CD200_01590	COG0789	Transcriptional regulator
CD200_01615	COG0697	spore germination
CD200_01620	COG1714	RDD family
CD200_01625	COG3012	SEC-C Motif Domain Protein
CD200_01625	COG1405	negative regulation of cell septum assembly
CD200_01655	COG0583	DNA-binding transcription factor activity
CD200_01660	COG1942	4-Oxalocrotonate Tautomerase
CD200_01665	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_01680	COG1288	antiporter activity
CD200_01690	COG0456	acetyltransferase
CD200_01700	COG1164	Oligoendopeptidase f
CD200_01705	COG2261	transglycosylase associated protein
CD200_01715	COG0247	lactate metabolic process
CD200_01720	COG0277	FAD linked oxidase domain protein
CD200_01725	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD200_01730	COG1447	Phosphotransferase system cellobiose-specific component IIA
CD200_01735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD200_01740	COG1486	melibiose metabolic process
CD200_01750	COG3394	polysaccharide catabolic process
CD200_01765	COG3591	Belongs to the peptidase S1B family
CD200_01770	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_01780	COG1595	DNA-templated transcription, initiation
CD200_01790	COG3773	Cell wall hydrolase
CD200_01795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CD200_01800	COG0791	NLP P60 protein
CD200_01800	COG3883	PFAM NLP P60 protein
CD200_01810	COG1131	(ABC) transporter
CD200_01815	COG1309	transcriptional regulator
CD200_01835	COG2310	stress, protein
CD200_01840	COG2310	stress, protein
CD200_01845	COG2310	stress, protein
CD200_01850	COG0861	Integral membrane protein TerC family
CD200_01870	COG3853	Toxic anion resistance protein (TelA)
CD200_01875	COG0785	Cytochrome C biogenesis protein
CD200_01885	COG0789	Transcriptional regulator
CD200_01890	COG2223	nitrite transmembrane transporter activity
CD200_01895	COG0039	L-malate dehydrogenase activity
CD200_01900	COG1620	l-lactate permease
CD200_01905	COG1280	lysine exporter protein (LysE YggA)
CD200_01910	COG1113	amino acid transport
CD200_01915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CD200_01920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CD200_01925	COG3541	Predicted nucleotidyltransferase
CD200_01930	COG0506	proline dehydrogenase activity
CD200_01935	COG1012	belongs to the aldehyde dehydrogenase family
CD200_01940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CD200_01945	COG2508	Transcriptional regulator
CD200_01950	COG3689	TIGRFAM TIGR03943 family protein
CD200_01955	COG0701	Predicted permease
CD200_01960	COG3458	cephalosporin-C deacetylase activity
CD200_01980	COG0765	amino acid transport
CD200_01985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CD200_01990	COG2249	NAD(P)H dehydrogenase (quinone) activity
CD200_02000	COG2723	6-phospho-beta-galactosidase activity
CD200_02010	COG3209	COG3209 Rhs family protein
CD200_02015	COG3266	domain, Protein
CD200_02015	COG0515	serine threonine protein kinase
CD200_02025	COG5444	nuclease activity
CD200_02050	COG1176	ABC-type spermidine putrescine transport system, permease component I
CD200_02055	COG1177	transmembrane transport
CD200_02060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CD200_02065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CD200_02070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CD200_02075	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CD200_02080	COG0697	spore germination
CD200_02085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD200_02095	COG2819	hydrolase of the alpha beta superfamily
CD200_02105	COG2364	Membrane
CD200_02115	COG1131	(ABC) transporter
CD200_02140	COG1126	abc transporter atp-binding protein
CD200_02145	COG0765	amino acid transport
CD200_02150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CD200_02155	COG3829	transcription factor binding
CD200_02160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CD200_02165	COG0833	amino acid
CD200_02170	COG0010	Belongs to the arginase family
CD200_02175	COG0583	DNA-binding transcription factor activity
CD200_02180	COG0163	prenyltransferase activity
CD200_02185	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CD200_02235	COG5444	nuclease activity
CD200_02255	COG2972	Histidine kinase
CD200_02260	COG4753	response regulator
CD200_02260	COG2207	Transcriptional regulator
CD200_02265	COG4213	ABC transporter substrate-binding protein
CD200_02275	COG4214	carbohydrate transport
CD200_02280	COG2271	Major facilitator Superfamily
CD200_02285	COG1846	Transcriptional regulator
CD200_02285	COG0456	acetyltransferase
CD200_02290	COG1874	Beta-galactosidase
CD200_02300	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
CD200_02305	COG3104	oligopeptide transport
CD200_02310	COG5434	Belongs to the glycosyl hydrolase 28 family
CD200_02320	COG0697	spore germination
CD200_02330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CD200_02335	COG0789	Transcriptional regulator
CD200_02340	COG1136	(ABC) transporter
CD200_02345	COG0577	efflux transmembrane transporter activity
CD200_02350	COG0745	RESPONSE REGULATOR receiver
CD200_02355	COG5002	protein histidine kinase activity
CD200_02355	COG3850	Histidine kinase
CD200_02365	COG0527	aspartate kinase activity
CD200_02370	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD200_02375	COG4605	iron ion homeostasis
CD200_02380	COG4604	ABC transporter, ATP-binding protein
CD200_02385	COG4607	ABC-type enterochelin transport system periplasmic component
CD200_02390	COG2814	Major facilitator Superfamily
CD200_02395	COG1309	transcriptional regulator
CD200_02405	COG0778	Nitroreductase
CD200_02410	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CD200_02415	COG0640	Transcriptional regulator
CD200_02420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD200_02425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CD200_02430	COG0531	amino acid
CD200_02435	COG1012	belongs to the aldehyde dehydrogenase family
CD200_02440	COG0697	spore germination
CD200_02450	COG4549	nuclear export factor GLE1
CD200_02455	COG2372	response to copper ion
CD200_02455	COG1276	copper resistance
CD200_02460	COG1349	DNA-binding transcription factor activity
CD200_02465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CD200_02470	COG0243	molybdopterin cofactor binding
CD200_02475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CD200_02480	COG2146	nitrite reductase [NAD(P)H] activity
CD200_02485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CD200_02485	COG1587	Uroporphyrinogen-III synthase
CD200_02490	COG1802	Transcriptional regulator
CD200_02495	COG0471	metal ion transport
CD200_02500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CD200_02505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CD200_02520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD200_02535	COG3959	Transketolase, thiamine diphosphate binding domain
CD200_02540	COG3958	Transketolase
CD200_02545	COG0561	phosphatase activity
CD200_02550	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CD200_02555	COG1914	H( )-stimulated, divalent metal cation uptake system
CD200_02560	COG4336	lyase activity
CD200_02565	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CD200_02570	COG1984	allophanate hydrolase subunit 2
CD200_02575	COG1414	Transcriptional regulator
CD200_02580	COG2755	lipolytic protein G-D-S-L family
CD200_02585	COG2213	PTS system mannitol-specific
CD200_02590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD200_02595	COG0246	Mannitol dehydrogenase
CD200_02600	COG3711	transcriptional antiterminator
CD200_02605	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_02610	COG1917	Cupin 2, conserved barrel domain protein
CD200_02620	COG3871	stress protein (general stress protein 26)
CD200_02630	COG1316	TRANSCRIPTIONal
CD200_02635	COG2814	Major facilitator Superfamily
CD200_02645	COG1522	sequence-specific DNA binding
CD200_02650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CD200_02650	COG0551	DNA topoisomerase type I activity
CD200_02655	COG0531	amino acid
CD200_02665	COG0028	Belongs to the TPP enzyme family
CD200_02670	COG3397	chitin binding
CD200_02680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CD200_02685	COG1914	H( )-stimulated, divalent metal cation uptake system
CD200_02690	COG2261	transglycosylase associated protein
CD200_02695	COG1027	Aspartate ammonia-lyase
CD200_02700	COG1819	glycosyl
CD200_02705	COG4876	unkown
CD200_02710	COG2217	Heavy metal translocating P-type atpase
CD200_02720	COG0662	Cupin 2, conserved barrel domain protein
CD200_02730	COG0628	permease
CD200_02735	COG1301	dicarboxylic acid transport
CD200_02740	COG1131	(ABC) transporter
CD200_02745	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CD200_02755	COG1960	acyl-CoA dehydrogenase activity
CD200_02770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD200_02775	COG1181	Belongs to the D-alanine--D-alanine ligase family
CD200_02780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CD200_02790	COG0513	Belongs to the DEAD box helicase family
CD200_02795	COG3402	PFAM membrane-flanked domain
CD200_02800	COG3428	Bacterial PH domain
CD200_02805	COG0705	Rhomboid family
CD200_02810	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CD200_02815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CD200_02820	COG0864	Transcriptional regulator
CD200_02825	COG2337	Toxic component of a toxin-antitoxin (TA) module
CD200_02830	COG1366	Belongs to the anti-sigma-factor antagonist family
CD200_02835	COG1366	Belongs to the anti-sigma-factor antagonist family
CD200_02840	COG2172	sigma factor antagonist activity
CD200_02845	COG2208	phosphoserine phosphatase activity
CD200_02855	COG2172	sigma factor antagonist activity
CD200_02860	COG1191	sigma factor activity
CD200_02865	COG2208	phosphoserine phosphatase activity
CD200_02870	COG2183	response to ionizing radiation
CD200_02875	COG1309	transcriptional regulator
CD200_02880	COG2409	Drug exporters of the RND superfamily
CD200_02880	COG1033	growth of symbiont in host cell
CD200_02890	COG3091	SprT-like family
CD200_02940	COG1476	TRANSCRIPTIONal
CD200_02945	COG3239	Fatty acid desaturase
CD200_02950	COG1278	Cold shock
CD200_02965	COG2364	Membrane
CD200_02970	COG1846	Transcriptional regulator
CD200_02975	COG0456	acetyltransferase
CD200_02980	COG2808	Putative FMN-binding domain
CD200_02990	COG1733	regulation of RNA biosynthetic process
CD200_02995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD200_03005	COG0583	DNA-binding transcription factor activity
CD200_03020	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CD200_03025	COG1113	amino acid transport
CD200_03040	COG1595	DNA-templated transcription, initiation
CD200_03050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CD200_03050	COG2755	lipolytic protein G-D-S-L family
CD200_03055	COG2814	Major facilitator Superfamily
CD200_03060	COG2972	Histidine kinase
CD200_03060	COG0745	RESPONSE REGULATOR receiver
CD200_03065	COG3279	Response regulator of the LytR AlgR family
CD200_03075	COG3764	Sortase (surface protein transpeptidase)
CD200_03080	COG2814	Major facilitator Superfamily
CD200_03120	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CD200_03125	COG0802	atpase or kinase
CD200_03130	COG1214	PFAM Peptidase M22, glycoprotease
CD200_03135	COG0456	acetyltransferase
CD200_03140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CD200_03145	COG0488	(ABC) transporter
CD200_03150	COG0315	cyclic pyranopterin monophosphate synthase activity
CD200_03155	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CD200_03160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CD200_03165	COG0805	protein transport
CD200_03175	COG1266	CAAX protease self-immunity
CD200_03180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CD200_03185	COG0459	protein refolding
CD200_03220	COG2720	vancomycin resistance protein
CD200_03235	COG2135	peptidase activity
CD200_03245	COG1309	transcriptional regulator
CD200_03250	COG0574	Belongs to the PEP-utilizing enzyme family
CD200_03250	COG3848	Pyruvate phosphate dikinase
CD200_03260	COG3189	MarR family transcriptional regulator
CD200_03265	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CD200_03270	COG2272	Belongs to the type-B carboxylesterase lipase family
CD200_03275	COG2814	Major facilitator Superfamily
CD200_03280	COG1842	Phage shock protein A
CD200_03285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CD200_03290	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CD200_03295	COG4260	virion core protein, lumpy skin disease virus
CD200_03305	COG1378	Sugar-specific transcriptional regulator TrmB
CD200_03310	COG1280	lysine exporter protein (LysE YggA)
CD200_03315	COG3339	Conserved Protein
CD200_03320	COG0772	Belongs to the SEDS family
CD200_03325	COG0772	Belongs to the SEDS family
CD200_03350	COG0726	polysaccharide deacetylase
CD200_03360	COG1609	Transcriptional regulator
CD200_03365	COG0366	Alpha amylase catalytic
CD200_03370	COG2182	Extracellular solute-binding protein
CD200_03375	COG1175	transmembrane transport
CD200_03380	COG3833	ABC-type maltose transport systems, permease component
CD200_03385	COG5521	maltodextrose utilization protein MalA
CD200_03390	COG1554	hydrolase, family 65, central catalytic
CD200_03395	COG0366	Alpha amylase catalytic
CD200_03400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CD200_03405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CD200_03410	COG1846	Transcriptional regulator
CD200_03425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CD200_03430	COG0823	Involved in the tonB-independent uptake of proteins
CD200_03460	COG0702	epimerase
CD200_03470	COG2132	Multicopper oxidase
CD200_03485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CD200_03490	COG0714	Associated with various cellular activities
CD200_03495	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CD200_03500	COG1305	Transglutaminase-like
CD200_03505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CD200_03505	COG0519	Catalyzes the synthesis of GMP from XMP
CD200_03515	COG2252	PERMEase
CD200_03530	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CD200_03540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CD200_03545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CD200_03550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CD200_03555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CD200_03560	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CD200_03565	COG0047	phosphoribosylformylglycinamidine synthase activity
CD200_03570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CD200_03575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CD200_03580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CD200_03585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CD200_03590	COG0138	bifunctional purine biosynthesis protein purh
CD200_03595	COG0151	Belongs to the GarS family
CD200_03610	COG2124	cytochrome p450
CD200_03630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CD200_03635	COG1470	cell adhesion involved in biofilm formation
CD200_03640	COG4496	protein, YerC YecD
CD200_03645	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CD200_03650	COG0210	DNA helicase
CD200_03655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CD200_03660	COG4851	CamS sex pheromone cAM373 precursor
CD200_03665	COG2188	Transcriptional regulator
CD200_03685	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CD200_03690	COG0626	cystathionine gamma-synthase activity
CD200_03695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CD200_03700	COG3457	Alanine racemase
CD200_03705	COG0363	glucosamine-6-phosphate deaminase activity
CD200_03710	COG1285	pathogenesis
CD200_03715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CD200_03720	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CD200_03725	COG0154	amidase activity
CD200_03730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CD200_03745	COG4124	Belongs to the glycosyl hydrolase 26 family
CD200_03750	COG1309	transcriptional regulator
CD200_03755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CD200_03765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CD200_03770	COG1957	nucleoside hydrolase
CD200_03775	COG1597	lipid kinase activity
CD200_03780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CD200_03790	COG2190	(PTS) system
CD200_03790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_03790	COG1263	PTS System
CD200_03795	COG2723	6-phospho-beta-galactosidase activity
CD200_03800	COG3711	transcriptional antiterminator
CD200_03805	COG0457	Tetratricopeptide repeat
CD200_03825	COG0217	transcriptional regulatory protein
CD200_03840	COG1012	belongs to the aldehyde dehydrogenase family
CD200_03845	COG0840	transmembrane signaling receptor activity
CD200_03850	COG0471	metal ion transport
CD200_03855	COG0488	(ABC) transporter
CD200_03860	COG1469	GTP cyclohydrolase I activity
CD200_03875	COG0523	cobalamin synthesis protein
CD200_03880	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
CD200_03885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CD200_03890	COG0156	8-amino-7-oxononanoate synthase activity
CD200_03895	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CD200_03900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CD200_03905	COG2124	cytochrome p450
CD200_03915	COG0789	Transcriptional regulator
CD200_03920	COG2814	Major facilitator Superfamily
CD200_03925	COG0488	(ABC) transporter
CD200_03930	COG0513	Belongs to the DEAD box helicase family
CD200_03935	COG2130	NADP-dependent
CD200_03950	COG0471	metal ion transport
CD200_03970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD200_03980	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CD200_03985	COG5658	integral membrane protein
CD200_03990	COG0640	Transcriptional regulator
CD200_03995	COG1254	Belongs to the acylphosphatase family
CD200_04000	COG2258	MOSC domain
CD200_04015	COG0024	Methionine aminopeptidase
CD200_04020	COG1368	sulfuric ester hydrolase activity
CD200_04030	COG1115	amino acid carrier protein
CD200_04035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_04035	COG1263	PTS System
CD200_04040	COG0366	Alpha amylase catalytic
CD200_04045	COG2188	Transcriptional regulator
CD200_04070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CD200_04075	COG1045	serine acetyltransferase
CD200_04080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CD200_04090	COG1215	transferase activity, transferring glycosyl groups
CD200_04095	COG0457	Tetratricopeptide repeat
CD200_04095	COG0463	Glycosyl transferase, family 2
CD200_04105	COG0673	inositol 2-dehydrogenase activity
CD200_04120	COG1733	regulation of RNA biosynthetic process
CD200_04125	COG0778	Nitroreductase
CD200_04130	COG0737	Belongs to the 5'-nucleotidase family
CD200_04135	COG0693	protein deglycase activity
CD200_04140	COG4840	Belongs to the UPF0435 family
CD200_04145	COG1115	amino acid carrier protein
CD200_04150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CD200_04155	COG4980	gas vesicle protein
CD200_04160	COG1295	ribonuclease BN
CD200_04165	COG0477	Major facilitator Superfamily
CD200_04175	COG0387	Pfam Sodium calcium exchanger
CD200_04185	COG0535	radical SAM domain protein
CD200_04195	COG0726	polysaccharide deacetylase
CD200_04200	COG0371	Dehydrogenase
CD200_04210	COG0598	Magnesium transport protein CorA
CD200_04215	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CD200_04220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CD200_04225	COG4637	Psort location Cytoplasmic, score
CD200_04250	COG1819	glycosyl
CD200_04260	COG0477	Major facilitator Superfamily
CD200_04265	COG1263	PTS System
CD200_04265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_04270	COG3711	transcriptional antiterminator
CD200_04275	COG0288	reversible hydration of carbon dioxide
CD200_04280	COG3002	Belongs to the UPF0753 family
CD200_04285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CD200_04290	COG5609	conserved protein (DUF2294)
CD200_04300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CD200_04305	COG0022	dehydrogenase e1 component
CD200_04310	COG0508	dehydrogenase complex catalyzes the overall conversion of
CD200_04315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CD200_04320	COG3284	Transcriptional regulator
CD200_04325	COG1742	UPF0060 membrane protein
CD200_04330	COG1486	melibiose metabolic process
CD200_04335	COG1737	Transcriptional regulator
CD200_04340	COG1263	PTS System
CD200_04340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_04355	COG1733	regulation of RNA biosynthetic process
CD200_04360	COG2259	Doxx family
CD200_04365	COG2514	catechol 2,3-dioxygenase activity
CD200_04375	COG3507	Belongs to the glycosyl hydrolase 43 family
CD200_04380	COG1917	Cupin 2, conserved barrel domain protein
CD200_04380	COG2207	Transcriptional regulator
CD200_04385	COG1653	transport
CD200_04390	COG2249	NAD(P)H dehydrogenase (quinone) activity
CD200_04395	COG1051	belongs to the nudix hydrolase family
CD200_04405	COG0392	lysyltransferase activity
CD200_04405	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CD200_04410	COG0384	phenazine biosynthesis protein PhzF
CD200_04415	COG0778	Nitroreductase
CD200_04435	COG1090	epimerase
CD200_04440	COG2137	regulation of response to DNA damage stimulus
CD200_04470	COG0463	Glycosyl transferase, family 2
CD200_04480	COG4485	Bacterial membrane protein, YfhO
CD200_04485	COG1988	membrane-bound metal-dependent
CD200_04490	COG1194	a g-specific adenine glycosylase
CD200_04500	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_04515	COG3557	Belongs to the UPF0374 family
CD200_04520	COG1132	(ABC) transporter
CD200_04525	COG0444	Belongs to the ABC transporter superfamily
CD200_04530	COG4608	Belongs to the ABC transporter superfamily
CD200_04535	COG0747	negative chemotaxis
CD200_04550	COG4129	membrane
CD200_04555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CD200_04560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CD200_04565	COG0735	belongs to the Fur family
CD200_04675	COG4974	Belongs to the 'phage' integrase family
CD200_04690	COG0582	viral genome integration into host DNA
CD200_04815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CD200_04825	COG0710	3-dehydroquinate dehydratase activity
CD200_04830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CD200_04835	COG1116	anion transmembrane transporter activity
CD200_04840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CD200_04845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CD200_04850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CD200_04860	COG1476	TRANSCRIPTIONal
CD200_04870	COG1131	(ABC) transporter
CD200_04890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CD200_04900	COG3382	B3 4 domain protein
CD200_04905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CD200_04915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CD200_04920	COG0789	Transcriptional regulator
CD200_04925	COG1664	Polymer-forming cytoskeletal
CD200_04935	COG2766	serine protein kinase
CD200_04940	COG2718	Belongs to the UPF0229 family
CD200_04945	COG1566	PFAM secretion protein HlyD family protein
CD200_04950	COG2814	Major facilitator Superfamily
CD200_04955	COG0655	NAD(P)H dehydrogenase (quinone) activity
CD200_04975	COG1131	(ABC) transporter
CD200_04980	COG1131	(ABC) transporter
CD200_04985	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CD200_04990	COG1278	Cold shock
CD200_04995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CD200_05000	COG2011	ABC-type metal ion transport system permease component
CD200_05005	COG1464	Belongs to the NlpA lipoprotein family
CD200_05010	COG1823	symporter activity
CD200_05035	COG5577	PFAM Coat F domain
CD200_05040	COG5002	protein histidine kinase activity
CD200_05045	COG0737	Belongs to the 5'-nucleotidase family
CD200_05045	COG4085	toxin activity
CD200_05045	COG1525	nuclease
CD200_05050	COG3764	Sortase (surface protein transpeptidase)
CD200_05055	COG0564	pseudouridine synthase activity
CD200_05065	COG0517	IMP dehydrogenase activity
CD200_05070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CD200_05075	COG3153	acetyltransferase
CD200_05075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CD200_05080	COG0488	(ABC) transporter
CD200_05090	COG2116	formate transmembrane transporter activity
CD200_05095	COG0679	Auxin Efflux Carrier
CD200_05100	COG0604	alcohol dehydrogenase
CD200_05105	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CD200_05110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CD200_05115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CD200_05125	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CD200_05130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CD200_05145	COG4585	Histidine kinase
CD200_05145	COG2203	Gaf domain
CD200_05150	COG2197	response regulator
CD200_05155	COG0431	NADPH-dependent FMN reductase
CD200_05170	COG1959	2 iron, 2 sulfur cluster binding
CD200_05175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CD200_05175	COG1017	nitric oxide dioxygenase activity
CD200_05180	COG2719	SpoVR family
CD200_05185	COG1388	LysM domain
CD200_05185	COG0791	NLP P60 protein
CD200_05190	COG0583	DNA-binding transcription factor activity
CD200_05195	COG0372	Belongs to the citrate synthase family
CD200_05200	COG2133	pyrroloquinoline quinone binding
CD200_05205	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_05210	COG0733	neurotransmitter:sodium symporter activity
CD200_05220	COG2207	Transcriptional regulator
CD200_05220	COG3708	Transcriptional regulator
CD200_05225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD200_05245	COG1595	DNA-templated transcription, initiation
CD200_05250	COG0662	Cupin 2, conserved barrel domain protein
CD200_05260	COG0204	Acyl-transferase
CD200_05265	COG3152	Membrane
CD200_05275	COG1309	transcriptional regulator
CD200_05280	COG1253	flavin adenine dinucleotide binding
CD200_05285	COG0789	Transcriptional regulator
CD200_05290	COG1253	flavin adenine dinucleotide binding
CD200_05310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CD200_05315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CD200_05320	COG0584	glycerophosphoryl diester phosphodiesterase
CD200_05330	COG0668	transmembrane transport
CD200_05335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CD200_05345	COG0726	polysaccharide deacetylase
CD200_05355	COG1757	Na H antiporter
CD200_05360	COG2017	converts alpha-aldose to the beta-anomer
CD200_05385	COG0589	response to stress
CD200_05390	COG1132	(ABC) transporter
CD200_05395	COG1132	(ABC) transporter
CD200_05400	COG0702	epimerase
CD200_05415	COG3842	ATPase activity
CD200_05420	COG2508	Transcriptional regulator
CD200_05430	COG0189	ligase activity
CD200_05435	COG0189	ligase activity
CD200_05440	COG4399	Belongs to the UPF0754 family
CD200_05445	COG3679	Belongs to the UPF0342 family
CD200_05455	COG0561	phosphatase activity
CD200_05460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CD200_05465	COG0475	glutathione-regulated potassium exporter activity
CD200_05470	COG0490	domain, Protein
CD200_05480	COG1024	Enoyl-CoA hydratase
CD200_05485	COG0457	Tetratricopeptide repeat
CD200_05500	COG4152	abc transporter atp-binding protein
CD200_05505	COG1668	transmembrane transport
CD200_05510	COG0420	3'-5' exonuclease activity
CD200_05515	COG4717	serine-type aminopeptidase activity
CD200_05520	COG3481	metal-dependent phosphohydrolase, HD sub domain
CD200_05530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CD200_05560	COG1846	Transcriptional regulator
CD200_05565	COG4980	gas vesicle protein
CD200_05580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CD200_05585	COG0537	adenosine 5'-monophosphoramidase activity
CD200_05595	COG1131	(ABC) transporter
CD200_05600	COG4473	ABC transporter
CD200_05610	COG1473	amidohydrolase
CD200_05615	COG3069	C4-dicarboxylate transmembrane transporter activity
CD200_05620	COG2329	Antibiotic biosynthesis monooxygenase
CD200_05625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CD200_05630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CD200_05645	COG1309	transcriptional regulator
CD200_05650	COG1511	domain protein
CD200_05655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CD200_05660	COG1363	Peptidase, m42
CD200_05670	COG1301	dicarboxylic acid transport
CD200_05680	COG1234	tRNA 3'-trailer cleavage
CD200_05685	COG0095	Lipoate-protein ligase
CD200_05690	COG0318	PFAM AMP-dependent synthetase and ligase
CD200_05700	COG1396	sequence-specific DNA binding
CD200_05715	COG0501	Belongs to the peptidase M48B family
CD200_05725	COG0697	spore germination
CD200_05730	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CD200_05735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD200_05740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD200_05745	COG0406	alpha-ribazole phosphatase activity
CD200_05750	COG0840	transmembrane signaling receptor activity
CD200_05755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD200_05755	COG0723	plastoquinol--plastocyanin reductase activity
CD200_05760	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_05770	COG4903	ComK protein
CD200_05780	COG0398	Pfam SNARE associated Golgi protein
CD200_05785	COG0681	Belongs to the peptidase S26 family
CD200_05790	COG1404	Belongs to the peptidase S8 family
CD200_05815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD200_05820	COG3257	ureidoglycine aminohydrolase activity
CD200_05825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CD200_05830	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CD200_05835	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CD200_05840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CD200_05855	COG2814	Major facilitator Superfamily
CD200_05865	COG0457	Tetratricopeptide repeat
CD200_05905	COG1486	melibiose metabolic process
CD200_05910	COG3180	Ammonia monooxygenase
CD200_05925	COG3546	catalase activity
CD200_05930	COG0318	PFAM AMP-dependent synthetase and ligase
CD200_05935	COG0477	Major facilitator Superfamily
CD200_05935	COG2814	Major facilitator Superfamily
CD200_05945	COG5002	protein histidine kinase activity
CD200_05950	COG0745	RESPONSE REGULATOR receiver
CD200_05955	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CD200_05960	COG0725	ABC transporter, periplasmic molybdate-binding protein
CD200_05965	COG4149	molybdate abc transporter
CD200_05970	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CD200_05975	COG1074	ATP-dependent DNA helicase activity
CD200_05980	COG0420	3'-5' exonuclease activity
CD200_05985	COG0419	ATPase involved in DNA repair
CD200_06030	COG5337	Spore coat protein CotH
CD200_06040	COG0179	Fumarylacetoacetate (FAA) hydrolase
CD200_06060	COG0367	asparagine synthase
CD200_06070	COG0347	Belongs to the P(II) protein family
CD200_06075	COG0534	Mate efflux family protein
CD200_06080	COG1917	Cupin 2, conserved barrel domain protein
CD200_06080	COG2207	Transcriptional regulator
CD200_06090	COG1609	Transcriptional regulator
CD200_06095	COG0673	inositol 2-dehydrogenase activity
CD200_06100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CD200_06110	COG0076	glutamate decarboxylase activity
CD200_06135	COG2153	protein acetylation
CD200_06140	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_06145	COG2378	regulation of single-species biofilm formation
CD200_06150	COG0646	methionine synthase
CD200_06150	COG1410	methionine synthase
CD200_06155	COG0646	methionine synthase
CD200_06155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CD200_06160	COG1666	GTP binding
CD200_06165	COG2996	Protein conserved in bacteria
CD200_06180	COG1307	EDD domain protein, DegV family
CD200_06185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD200_06195	COG0516	GMP reductase activity
CD200_06205	COG0561	phosphatase activity
CD200_06210	COG1073	alpha beta
CD200_06215	COG2151	metal-sulfur cluster biosynthetic enzyme
CD200_06225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CD200_06230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CD200_06235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CD200_06240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CD200_06245	COG0505	Belongs to the CarA family
CD200_06250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CD200_06255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CD200_06260	COG1968	undecaprenyl-diphosphatase activity
CD200_06275	COG2267	carboxylic ester hydrolase activity
CD200_06285	COG1744	ABC transporter substrate-binding protein PnrA-like
CD200_06300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CD200_06305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CD200_06310	COG5504	Zn-dependent protease
CD200_06315	COG0444	Belongs to the ABC transporter superfamily
CD200_06320	COG4608	Belongs to the ABC transporter superfamily
CD200_06330	COG0601	transmembrane transport
CD200_06335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CD200_06360	COG0180	Tryptophanyl-tRNA synthetase
CD200_06370	COG4166	transmembrane transport
CD200_06375	COG0601	transmembrane transport
CD200_06380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CD200_06385	COG0444	Belongs to the ABC transporter superfamily
CD200_06390	COG4608	Belongs to the ABC transporter superfamily
CD200_06395	COG0456	acetyltransferase
CD200_06400	COG1393	Belongs to the ArsC family
CD200_06405	COG0861	Integral membrane protein TerC family
CD200_06410	COG4862	establishment of competence for transformation
CD200_06430	COG4565	transcriptional regulatory protein
CD200_06435	COG3290	protein histidine kinase activity
CD200_06440	COG4469	Competence protein
CD200_06445	COG1164	Oligoendopeptidase f
CD200_06460	COG2346	COG2346, Truncated hemoglobins
CD200_06465	COG0741	lytic transglycosylase activity
CD200_06470	COG4116	CYTH
CD200_06480	COG2357	RelA SpoT domain protein
CD200_06485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CD200_06490	COG0564	pseudouridine synthase activity
CD200_06495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CD200_06505	COG0475	glutathione-regulated potassium exporter activity
CD200_06505	COG0569	domain protein
CD200_06510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CD200_06515	COG0352	thiamine-phosphate diphosphorylase activity
CD200_06525	COG2104	thiamine diphosphate biosynthetic process
CD200_06530	COG2022	thiamine diphosphate biosynthetic process
CD200_06535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CD200_06540	COG0351	phosphomethylpyrimidine kinase
CD200_06545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CD200_06600	COG0210	DNA helicase
CD200_06610	COG0586	Pfam SNARE associated Golgi protein
CD200_06615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CD200_06620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CD200_06625	COG2246	polysaccharide biosynthetic process
CD200_06630	COG2153	protein acetylation
CD200_06635	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CD200_06640	COG2382	esterase
CD200_06660	COG0626	cystathionine gamma-synthase activity
CD200_06665	COG0626	cystathionine gamma-synthase activity
CD200_06670	COG5505	Protein of unknown function (DUF819)
CD200_06685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CD200_06690	COG3507	Belongs to the glycosyl hydrolase 43 family
CD200_06710	COG0110	maltose O-acetyltransferase activity
CD200_06720	COG0583	DNA-binding transcription factor activity
CD200_06725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CD200_06730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CD200_06740	COG0583	DNA-binding transcription factor activity
CD200_06745	COG0697	spore germination
CD200_06750	COG0346	lactoylglutathione lyase activity
CD200_06760	COG1388	LysM domain
CD200_06760	COG3584	3D domain protein
CD200_06765	COG2814	Major facilitator Superfamily
CD200_06770	COG1309	transcriptional regulator
CD200_06790	COG5444	nuclease activity
CD200_06795	COG4195	phage-related replication protein
CD200_06800	COG2856	Zn peptidase
CD200_06805	COG1396	sequence-specific DNA binding
CD200_06820	COG1522	sequence-specific DNA binding
CD200_06825	COG1484	DNA-dependent DNA replication
CD200_06840	COG1595	DNA-templated transcription, initiation
CD200_06845	COG5484	DNA packaging
CD200_06845	COG3728	DNA packaging
CD200_06850	COG1783	phage Terminase large subunit
CD200_06855	COG5518	Phage portal protein
CD200_06860	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CD200_06865	COG4653	Phage capsid family
CD200_06915	COG5412	phage tail tape measure protein
CD200_06915	COG3953	SLT domain
CD200_06920	COG1652	LysM domain
CD200_06925	COG4193	domain, Protein
CD200_06935	COG3628	GPW Gp25 family protein
CD200_06940	COG3299	homolog of phage Mu protein gp47
CD200_06945	COG3778	Protein conserved in bacteria
CD200_06980	COG1802	Transcriptional regulator
CD200_06985	COG1063	alcohol dehydrogenase
CD200_06990	COG1312	Catalyzes the dehydration of D-mannonate
CD200_06995	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_07000	COG1063	alcohol dehydrogenase
CD200_07005	COG2271	Major facilitator Superfamily
CD200_07020	COG0306	phosphate transporter
CD200_07025	COG1392	Phosphate transport regulator
CD200_07030	COG0405	Gamma-glutamyltransferase
CD200_07035	COG5578	integral membrane protein
CD200_07040	COG2972	Histidine kinase
CD200_07045	COG2207	Transcriptional regulator
CD200_07045	COG4753	response regulator
CD200_07050	COG1653	transport
CD200_07055	COG1175	transmembrane transport
CD200_07060	COG0395	ABC-type sugar transport system, permease component
CD200_07065	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CD200_07070	COG2207	Transcriptional regulator
CD200_07075	COG2755	lipolytic protein G-D-S-L family
CD200_07085	COG5578	integral membrane protein
CD200_07100	COG2755	lipolytic protein G-D-S-L family
CD200_07105	COG3401	FG-GAP repeat protein
CD200_07110	COG0667	Aldo Keto reductase
CD200_07115	COG2755	lipolytic protein G-D-S-L family
CD200_07120	COG1874	Beta-galactosidase
CD200_07130	COG1653	transport
CD200_07135	COG4209	transmembrane transport
CD200_07140	COG0395	ABC-type sugar transport system, permease component
CD200_07145	COG0531	amino acid
CD200_07150	COG0346	lactoylglutathione lyase activity
CD200_07160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CD200_07165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CD200_07170	COG2362	D-Aminopeptidase
CD200_07175	COG0601	transmembrane transport
CD200_07180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CD200_07185	COG0444	Belongs to the ABC transporter superfamily
CD200_07190	COG4166	transmembrane transport
CD200_07195	COG1619	proteins homologs of microcin C7 resistance protein MccF
CD200_07205	COG0791	NLP P60 protein
CD200_07210	COG4608	Belongs to the ABC transporter superfamily
CD200_07215	COG1834	amidinotransferase
CD200_07220	COG1607	acyl-coa hydrolase
CD200_07230	COG3866	Pectate lyase
CD200_07250	COG2318	DinB family
CD200_07255	COG2076	Multidrug Resistance protein
CD200_07260	COG2076	Multidrug Resistance protein
CD200_07265	COG0788	formyltetrahydrofolate deformylase activity
CD200_07270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CD200_07275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CD200_07280	COG1764	response to oxidative stress
CD200_07285	COG1846	Transcriptional regulator
CD200_07290	COG1764	response to oxidative stress
CD200_07300	COG0590	tRNA wobble adenosine to inosine editing
CD200_07305	COG0406	alpha-ribazole phosphatase activity
CD200_07320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CD200_07325	COG1404	Belongs to the peptidase S8 family
CD200_07335	COG2239	Acts as a magnesium transporter
CD200_07345	COG0789	Transcriptional regulator
CD200_07360	COG1846	Transcriptional regulator
CD200_07365	COG3285	dna ligase
CD200_07365	COG1793	dna ligase
CD200_07370	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CD200_07375	COG5001	Diguanylate cyclase
CD200_07375	COG3300	MHYT domain
CD200_07380	COG0586	Pfam SNARE associated Golgi protein
CD200_07385	COG0861	Integral membrane protein TerC family
CD200_07390	COG1191	sigma factor activity
CD200_07410	COG0501	Belongs to the peptidase M48B family
CD200_07415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CD200_07420	COG0768	penicillin binding
CD200_07435	COG3594	Acyltransferase
CD200_07440	COG5002	protein histidine kinase activity
CD200_07445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CD200_07450	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CD200_07455	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CD200_07460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CD200_07465	COG0436	Aminotransferase
CD200_07470	COG1850	ribulose-bisphosphate carboxylase activity
CD200_07475	COG0235	Class ii aldolase
CD200_07475	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CD200_07480	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CD200_07485	COG0346	lactoylglutathione lyase activity
CD200_07490	COG3339	Conserved Protein
CD200_07500	COG3852	Histidine kinase
CD200_07505	COG1846	Transcriptional regulator
CD200_07510	COG1360	Flagellar Motor Protein
CD200_07515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CD200_07520	COG0542	response to heat
CD200_07525	COG3949	Membrane
CD200_07530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CD200_07535	COG0720	synthase
CD200_07540	COG0602	queuosine metabolic process
CD200_07545	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CD200_07670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CD200_07670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CD200_07705	COG1780	Probably involved in ribonucleotide reductase function
CD200_07710	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD200_07720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD200_07725	COG0756	dUTP diphosphatase activity
CD200_07740	COG3584	3D domain protein
CD200_07795	COG1793	dna ligase
CD200_07870	COG0740	serine-type endopeptidase activity
CD200_07920	COG5280	Phage tail tape measure protein TP901
CD200_07920	COG3953	SLT domain
CD200_07960	COG5632	N-Acetylmuramoyl-L-alanine amidase
CD200_07960	COG1388	LysM domain
CD200_07960	COG3409	Peptidoglycan-binding domain 1 protein
CD200_07980	COG0438	transferase activity, transferring glycosyl groups
CD200_08000	COG0582	viral genome integration into host DNA
CD200_08015	COG3739	integral membrane protein
CD200_08020	COG3655	Transcriptional regulator
CD200_08050	COG4873	Protein conserved in bacteria
CD200_08060	COG3773	Cell wall hydrolase
CD200_08065	COG2244	polysaccharide biosynthetic process
CD200_08070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD200_08075	COG2217	Heavy metal translocating P-type atpase
CD200_08080	COG0006	proline dipeptidase activity
CD200_08090	COG1609	Transcriptional regulator
CD200_08095	COG3711	transcriptional antiterminator
CD200_08100	COG2190	(PTS) system
CD200_08100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_08100	COG1263	PTS System
CD200_08105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD200_08110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CD200_08120	COG1533	DNA photolyase activity
CD200_08125	COG0456	acetyltransferase
CD200_08130	COG0840	transmembrane signaling receptor activity
CD200_08135	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_08140	COG2084	Dehydrogenase
CD200_08145	COG2340	Cysteine-rich secretory protein family
CD200_08150	COG0768	penicillin binding
CD200_08155	COG4191	Histidine kinase
CD200_08160	COG0436	Aminotransferase
CD200_08165	COG1714	RDD family
CD200_08175	COG0784	Response regulator, receiver
CD200_08175	COG0835	chemotaxis
CD200_08185	COG2814	Major facilitator Superfamily
CD200_08190	COG1376	ErfK ybiS ycfS ynhG family protein
CD200_08200	COG1408	metallophosphoesterase
CD200_08205	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_08210	COG2200	EAL domain
CD200_08220	COG4703	Protein of unknown function (DUF1797)
CD200_08230	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CD200_08240	COG0517	IMP dehydrogenase activity
CD200_08245	COG0583	DNA-binding transcription factor activity
CD200_08250	COG0716	FMN binding
CD200_08260	COG0716	FMN binding
CD200_08265	COG2171	N-acyltransferase activity
CD200_08270	COG1473	amidohydrolase
CD200_08280	COG0450	alkyl hydroperoxide reductase
CD200_08285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD200_08300	COG0746	molybdenum cofactor guanylyltransferase activity
CD200_08305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CD200_08310	COG0303	'Molybdopterin
CD200_08315	COG1763	Mo-molybdopterin cofactor biosynthetic process
CD200_08320	COG0314	molybdopterin synthase activity
CD200_08325	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CD200_08335	COG1132	(ABC) transporter
CD200_08340	COG1132	(ABC) transporter
CD200_08350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CD200_08355	COG1136	(ABC) transporter
CD200_08360	COG0577	efflux transmembrane transporter activity
CD200_08365	COG1349	DNA-binding transcription factor activity
CD200_08370	COG1105	Belongs to the carbohydrate kinase PfkB family
CD200_08375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD200_08375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD200_08375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD200_08395	COG0488	(ABC) transporter
CD200_08405	COG2309	aminopeptidase activity
CD200_08415	COG1077	Cell shape determining protein MreB Mrl
CD200_08420	COG2002	toxin-antitoxin pair type II binding
CD200_08425	COG3852	Histidine kinase
CD200_08430	COG0569	domain protein
CD200_08435	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CD200_08440	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CD200_08450	COG0561	phosphatase activity
CD200_08460	COG0242	peptide deformylase activity
CD200_08470	COG0497	DNA recombination
CD200_08475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CD200_08480	COG0022	dehydrogenase e1 component
CD200_08485	COG0508	dehydrogenase complex catalyzes the overall conversion of
CD200_08490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CD200_08495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD200_08505	COG1982	Orn Lys Arg decarboxylase major
CD200_08510	COG4476	Belongs to the UPF0223 family
CD200_08515	COG4493	Belongs to the UPF0637 family
CD200_08525	COG0483	inositol monophosphate 1-phosphatase activity
CD200_08545	COG1595	DNA-templated transcription, initiation
CD200_08570	COG1846	Transcriptional regulator
CD200_08575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CD200_08580	COG4896	Protein conserved in bacteria
CD200_08590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CD200_08595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CD200_08600	COG2066	Belongs to the glutaminase family
CD200_08605	COG4838	Belongs to the UPF0358 family
CD200_08610	COG0772	Belongs to the SEDS family
CD200_08615	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CD200_08620	COG1612	heme a metabolic process
CD200_08625	COG0109	protoheme IX farnesyltransferase activity
CD200_08630	COG2010	Cytochrome c
CD200_08630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CD200_08635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CD200_08640	COG1845	cytochrome c oxidase, subunit III
CD200_08645	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CD200_08650	COG3336	cytochrome c oxidase
CD200_08660	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CD200_08665	COG2340	Cysteine-rich secretory protein family
CD200_08680	COG3679	Belongs to the UPF0342 family
CD200_08685	COG4471	UPF0298 protein
CD200_08690	COG0742	ribosomal rna small subunit methyltransferase
CD200_08695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CD200_08700	COG3314	Sporulation integral membrane protein YlbJ
CD200_08705	COG3480	Lon protease (S16) C-terminal proteolytic domain
CD200_08710	COG1323	Belongs to the UPF0348 family
CD200_08715	COG1399	metal-binding, possibly nucleic acid-binding protein
CD200_08720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CD200_08730	COG0454	-acetyltransferase
CD200_08735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CD200_08740	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CD200_08745	COG2001	Belongs to the MraZ family
CD200_08750	COG0275	rRNA processing
CD200_08755	COG4839	cell division protein FtsL
CD200_08765	COG0768	penicillin binding
CD200_08770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CD200_08775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CD200_08780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CD200_08785	COG0772	Belongs to the SEDS family
CD200_08790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CD200_08795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CD200_08800	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CD200_08805	COG3879	Bacterial protein of unknown function (DUF881)
CD200_08810	COG3879	Bacterial protein of unknown function (DUF881)
CD200_08815	COG3856	small basic protein
CD200_08820	COG0849	cell division
CD200_08825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CD200_08830	COG4412	M6 family metalloprotease domain protein
CD200_08830	COG1404	Belongs to the peptidase S8 family
CD200_08835	COG1404	Belongs to the peptidase S8 family
CD200_08835	COG4412	M6 family metalloprotease domain protein
CD200_08845	COG1191	sigma factor activity
CD200_08850	COG1191	sigma factor activity
CD200_08855	COG1119	ATPase activity
CD200_08860	COG0500	methyltransferase
CD200_08865	COG1873	PFAM PRC-barrel domain
CD200_08875	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CD200_08880	COG1799	cell septum assembly
CD200_08885	COG0762	integral membrane protein
CD200_08890	COG2302	S4 RNA-binding domain
CD200_08895	COG3599	regulation of cell shape
CD200_08900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CD200_08905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CD200_08910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CD200_08915	COG0564	pseudouridine synthase activity
CD200_08920	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CD200_08925	COG2233	PERMEase
CD200_08930	COG0540	Belongs to the ATCase OTCase family
CD200_08935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CD200_08940	COG0505	Belongs to the CarA family
CD200_08945	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CD200_08950	COG0543	2 iron, 2 sulfur cluster binding
CD200_08955	COG0167	dihydroorotate dehydrogenase activity
CD200_08960	COG0284	orotidine-5'-phosphate decarboxylase activity
CD200_08965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CD200_08975	COG0175	sulfate reduction
CD200_08980	COG0306	phosphate transporter
CD200_08985	COG2046	Belongs to the sulfate adenylyltransferase family
CD200_08990	COG0529	Catalyzes the synthesis of activated sulfate
CD200_08995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CD200_09000	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CD200_09005	COG1648	precorrin-2 dehydrogenase activity
CD200_09015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CD200_09020	COG1561	YicC-like family, N-terminal region
CD200_09025	COG2052	Domain of unknown function (DUF370)
CD200_09030	COG0194	GDP metabolic process
CD200_09035	COG1758	RNA polymerase activity
CD200_09040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CD200_09045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CD200_09050	COG0242	peptide deformylase activity
CD200_09055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CD200_09060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CD200_09060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CD200_09065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CD200_09070	COG0631	protein serine/threonine phosphatase activity
CD200_09075	COG0515	serine threonine protein kinase
CD200_09075	COG2815	serine threonine protein kinase
CD200_09080	COG1162	GTPase activity
CD200_09085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CD200_09090	COG1564	THIamine pyrophosphokinase
CD200_09100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CD200_09105	COG1302	Protein conserved in bacteria
CD200_09110	COG1461	Dihydroxyacetone kinase
CD200_09115	COG1760	l-serine dehydratase
CD200_09120	COG1760	l-serine dehydratase
CD200_09125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CD200_09130	COG1349	DNA-binding transcription factor activity
CD200_09135	COG0416	fatty acid biosynthetic process
CD200_09140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CD200_09145	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_09150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CD200_09155	COG0571	ribonuclease III activity
CD200_09160	COG1196	nuclear chromosome segregation
CD200_09165	COG0552	protein localization to endoplasmic reticulum
CD200_09170	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CD200_09175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CD200_09180	COG0228	four-way junction DNA binding
CD200_09185	COG1837	Belongs to the UPF0109 family
CD200_09195	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CD200_09200	COG0336	Belongs to the RNA methyltransferase TrmD family
CD200_09205	COG0335	large ribosomal subunit rRNA binding
CD200_09210	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CD200_09215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CD200_09225	COG2257	FlhB HrpN YscU SpaS Family
CD200_09230	COG0045	succinate-CoA ligase (ADP-forming) activity
CD200_09235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CD200_09240	COG0758	DNA mediated transformation
CD200_09245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CD200_09250	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CD200_09255	COG4974	Belongs to the 'phage' integrase family
CD200_09260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CD200_09265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CD200_09270	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CD200_09275	COG1815	bacterial-type flagellum-dependent cell motility
CD200_09280	COG1558	bacterial-type flagellum-dependent cell motility
CD200_09285	COG1677	Flagellar hook-basal body complex protein FliE
CD200_09290	COG1766	The M ring may be actively involved in energy transduction
CD200_09295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CD200_09300	COG1317	bacterial-type flagellum organization
CD200_09305	COG1157	protein secretion by the type III secretion system
CD200_09310	COG2882	bacterial-type flagellum organization
CD200_09320	COG3144	bacterial-type flagellum assembly
CD200_09325	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CD200_09330	COG4786	Flagellar basal body rod
CD200_09335	COG1582	Flagellar protein (FlbD)
CD200_09340	COG1580	Controls the rotational direction of flagella during chemotaxis
CD200_09345	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CD200_09350	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CD200_09350	COG1776	CheC inhibitor of MCP methylation
CD200_09355	COG2201	protein-glutamate methylesterase activity
CD200_09360	COG3190	flagellar
CD200_09365	COG1338	Plays a role in the flagellum-specific transport system
CD200_09370	COG1987	bacterial-type flagellum assembly
CD200_09375	COG1684	flagellar biosynthetic protein fliR
CD200_09380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CD200_09385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CD200_09390	COG1419	protein localization to endoplasmic reticulum
CD200_09395	COG0455	bacterial-type flagellum organization
CD200_09400	COG2201	protein-glutamate methylesterase activity
CD200_09405	COG2198	Histidine kinase
CD200_09405	COG0643	Histidine kinase
CD200_09410	COG0835	chemotaxis
CD200_09415	COG1776	CheC inhibitor of MCP methylation
CD200_09420	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CD200_09425	COG1191	sigma factor activity
CD200_09435	COG0052	Belongs to the universal ribosomal protein uS2 family
CD200_09440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CD200_09445	COG0528	UMP kinase activity
CD200_09450	COG0233	cytoplasmic translational termination
CD200_09455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CD200_09460	COG4589	Belongs to the CDS family
CD200_09465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CD200_09470	COG0750	zinc metalloprotease
CD200_09475	COG0442	prolyl-tRNA aminoacylation
CD200_09480	COG2176	DNA-directed DNA polymerase activity
CD200_09510	COG0779	Required for maturation of 30S ribosomal subunits
CD200_09515	COG0195	Participates in both transcription termination and antitermination
CD200_09520	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CD200_09525	COG1358	cellular component organization or biogenesis
CD200_09530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CD200_09535	COG1550	Protein conserved in bacteria
CD200_09540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CD200_09545	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CD200_09550	COG0196	riboflavin kinase activity
CD200_09555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CD200_09560	COG1185	polyribonucleotide nucleotidyltransferase activity
CD200_09565	COG0726	polysaccharide deacetylase
CD200_09570	COG0612	Peptidase, M16
CD200_09575	COG1873	PFAM PRC-barrel domain
CD200_09580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CD200_09585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CD200_09590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CD200_09595	COG0527	aspartate kinase activity
CD200_09605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CD200_09610	COG0740	serine-type endopeptidase activity
CD200_09620	COG4980	gas vesicle protein
CD200_09620	COG1674	ftsk spoiiie
CD200_09625	COG2188	Transcriptional regulator
CD200_09630	COG2814	Major facilitator Superfamily
CD200_09635	COG0612	Peptidase, M16
CD200_09640	COG0612	Peptidase, M16
CD200_09645	COG0300	oxidoreductase activity
CD200_09660	COG1426	Protein conserved in bacteria
CD200_09665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CD200_09670	COG1058	Belongs to the CinA family
CD200_09670	COG1546	Belongs to the CinA family
CD200_09675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CD200_09680	COG1418	mRNA catabolic process
CD200_09685	COG1692	metallophosphoesterase
CD200_09690	COG2359	stage V sporulation protein S
CD200_09700	COG1063	alcohol dehydrogenase
CD200_09705	COG0156	8-amino-7-oxononanoate synthase activity
CD200_09710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CD200_09715	COG4550	Control of competence regulator ComK, YlbF/YmcA
CD200_09725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CD200_09730	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CD200_09735	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CD200_09740	COG5444	nuclease activity
CD200_09760	COG0523	cobalamin synthesis protein
CD200_09770	COG1247	-acetyltransferase
CD200_09785	COG1231	oxidoreductase activity
CD200_09790	COG3619	membrane
CD200_09795	COG3263	regulation of cellular component size
CD200_09805	COG2267	carboxylic ester hydrolase activity
CD200_09810	COG2267	carboxylic ester hydrolase activity
CD200_09820	COG0393	Putative heavy-metal-binding
CD200_09825	COG0398	Pfam SNARE associated Golgi protein
CD200_09830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CD200_09835	COG1819	glycosyl
CD200_09840	COG0531	amino acid
CD200_09845	COG5577	PFAM Coat F domain
CD200_09855	COG1388	LysM domain
CD200_09855	COG3858	chitin binding
CD200_09860	COG1309	transcriptional regulator
CD200_09865	COG3631	Ketosteroid isomerase-related protein
CD200_09870	COG0702	epimerase
CD200_09880	COG1764	response to oxidative stress
CD200_09885	COG2076	Multidrug Resistance protein
CD200_09890	COG2076	Multidrug Resistance protein
CD200_09905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CD200_09910	COG1923	regulation of RNA biosynthetic process
CD200_09925	COG1780	Probably involved in ribonucleotide reductase function
CD200_09930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD200_09935	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CD200_09940	COG4112	unkown
CD200_09955	COG0735	belongs to the Fur family
CD200_09960	COG1802	Transcriptional regulator
CD200_09965	COG0697	spore germination
CD200_10000	COG1309	transcriptional regulator
CD200_10050	COG0464	growth
CD200_10055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CD200_10060	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CD200_10065	COG0789	Transcriptional regulator
CD200_10070	COG0174	glutamine synthetase
CD200_10115	COG1073	alpha beta
CD200_10155	COG1309	transcriptional regulator
CD200_10160	COG2076	Multidrug Resistance protein
CD200_10165	COG2076	Multidrug Resistance protein
CD200_10170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CD200_10185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD200_10190	COG3546	catalase activity
CD200_10215	COG1846	Transcriptional regulator
CD200_10220	COG0778	Nitroreductase
CD200_10225	COG0346	lactoylglutathione lyase activity
CD200_10230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CD200_10235	COG0655	NAD(P)H dehydrogenase (quinone) activity
CD200_10250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CD200_10255	COG3209	COG3209 Rhs family protein
CD200_10260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CD200_10265	COG1388	LysM domain
CD200_10270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CD200_10275	COG4224	UPF0291 protein
CD200_10280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CD200_10290	COG3763	UPF0154 protein
CD200_10300	COG0785	Cytochrome C biogenesis protein
CD200_10305	COG2201	protein-glutamate methylesterase activity
CD200_10310	COG4846	Membrane protein involved in cytochrome C biogenesis
CD200_10320	COG0071	Belongs to the small heat shock protein (HSP20) family
CD200_10335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CD200_10340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD200_10360	COG0824	Thioesterase
CD200_10385	COG4841	protein insertion into membrane
CD200_10390	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CD200_10395	COG1832	CoA-binding protein
CD200_10400	COG0187	DNA topoisomerase II activity
CD200_10405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CD200_10410	COG1609	Transcriptional regulator
CD200_10425	COG2160	L-arabinose isomerase activity
CD200_10445	COG1115	amino acid carrier protein
CD200_10455	COG2181	nitrate reductase activity
CD200_10460	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CD200_10465	COG1140	nitrate reductase beta subunit
CD200_10470	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CD200_10490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CD200_10500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CD200_10505	COG2223	nitrite transmembrane transporter activity
CD200_10525	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CD200_10535	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CD200_10545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CD200_10570	COG3420	alginic acid biosynthetic process
CD200_10575	COG1114	Component of the transport system for branched-chain amino acids
CD200_10585	COG0789	Transcriptional regulator
CD200_10610	COG1024	Enoyl-CoA hydratase
CD200_10615	COG1012	belongs to the aldehyde dehydrogenase family
CD200_10620	COG2084	Dehydrogenase
CD200_10625	COG1960	acyl-CoA dehydrogenase activity
CD200_10630	COG1482	cell wall glycoprotein biosynthetic process
CD200_10635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD200_10635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD200_10635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD200_10655	COG3711	transcriptional antiterminator
CD200_10655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD200_10670	COG1725	Transcriptional regulator
CD200_10675	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_10680	COG1312	Catalyzes the dehydration of D-mannonate
CD200_10695	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CD200_10705	COG1609	Transcriptional regulator
CD200_10710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CD200_10715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CD200_10720	COG0640	Transcriptional regulator
CD200_10730	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CD200_10745	COG1649	PFAM Uncharacterised BCR, COG1649
CD200_10750	COG2404	hydrolase activity, acting on ester bonds
CD200_10755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CD200_10765	COG2027	D-alanyl-D-alanine carboxypeptidase
CD200_10770	COG1252	NADH dehydrogenase
CD200_10785	COG0166	Belongs to the GPI family
CD200_10795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CD200_10800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CD200_10805	COG1024	Enoyl-CoA hydratase
CD200_10810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CD200_10815	COG0511	ligase activity, forming carbon-carbon bonds
CD200_10820	COG0439	Biotin carboxylase
CD200_10825	COG0318	PFAM AMP-dependent synthetase and ligase
CD200_10830	COG1960	acyl-CoA dehydrogenase activity
CD200_10835	COG2249	NAD(P)H dehydrogenase (quinone) activity
CD200_10840	COG1733	regulation of RNA biosynthetic process
CD200_10845	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CD200_10850	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CD200_10860	COG2323	membrane
CD200_10870	COG0306	phosphate transporter
CD200_10875	COG0175	sulfate reduction
CD200_10880	COG1809	phosphosulfolactate synthase activity
CD200_10885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD200_10890	COG4948	Mandelate Racemase Muconate Lactonizing
CD200_10895	COG2814	Major facilitator Superfamily
CD200_10900	COG0463	Glycosyl transferase, family 2
CD200_10915	COG0493	'glutamate synthase
CD200_10920	COG0070	glutamate synthase
CD200_10920	COG0069	glutamate synthase activity
CD200_10920	COG0067	glutamate synthase
CD200_10925	COG0583	DNA-binding transcription factor activity
CD200_10945	COG1846	Transcriptional regulator
CD200_10955	COG1132	(ABC) transporter
CD200_10965	COG0300	oxidoreductase activity
CD200_10980	COG0477	Major facilitator Superfamily
CD200_10985	COG0243	molybdopterin cofactor binding
CD200_10990	COG1846	Transcriptional regulator
CD200_10995	COG2814	Major facilitator Superfamily
CD200_11000	COG0531	amino acid
CD200_11010	COG0531	amino acid
CD200_11015	COG0531	amino acid
CD200_11020	COG0697	spore germination
CD200_11035	COG0840	transmembrane signaling receptor activity
CD200_11040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CD200_11045	COG1404	Belongs to the peptidase S8 family
CD200_11055	COG1309	transcriptional regulator
CD200_11060	COG1846	Transcriptional regulator
CD200_11090	COG1309	transcriptional regulator
CD200_11100	COG3708	Transcriptional regulator
CD200_11110	COG2378	regulation of single-species biofilm formation
CD200_11120	COG0640	Transcriptional regulator
CD200_11125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD200_11135	COG0531	amino acid
CD200_11140	COG0741	lytic transglycosylase activity
CD200_11145	COG1086	Polysaccharide biosynthesis protein
CD200_11165	COG2322	membrane
CD200_11180	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CD200_11185	COG1388	LysM domain
CD200_11185	COG3584	3D domain protein
CD200_11190	COG0514	ATP-dependent DNA helicase (RecQ)
CD200_11210	COG2315	Protein conserved in bacteria
CD200_11230	COG0402	S-adenosylhomocysteine deaminase activity
CD200_11245	COG2267	carboxylic ester hydrolase activity
CD200_11260	COG1280	lysine exporter protein (LysE YggA)
CD200_11265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CD200_11275	COG0574	Belongs to the PEP-utilizing enzyme family
CD200_11275	COG3848	Pyruvate phosphate dikinase
CD200_11280	COG1309	transcriptional regulator
CD200_11295	COG2318	DinB family
CD200_11300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CD200_11305	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CD200_11320	COG1012	belongs to the aldehyde dehydrogenase family
CD200_11325	COG2814	Major facilitator Superfamily
CD200_11340	COG1657	PFAM Prenyltransferase squalene oxidase
CD200_11345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CD200_11355	COG0733	neurotransmitter:sodium symporter activity
CD200_11360	COG0385	Bile acid
CD200_11365	COG0508	dehydrogenase complex catalyzes the overall conversion of
CD200_11370	COG0567	Dehydrogenase, E1 component
CD200_11375	COG4548	von Willebrand factor, type A
CD200_11380	COG0714	Associated with various cellular activities
CD200_11385	COG2032	superoxide dismutase activity
CD200_11390	COG1388	LysM domain
CD200_11390	COG0791	NLP P60 protein
CD200_11400	COG0534	Mate efflux family protein
CD200_11405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CD200_11410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CD200_11420	COG2962	Rard protein
CD200_11430	COG4305	rare lipoprotein A
CD200_11445	COG1733	regulation of RNA biosynthetic process
CD200_11450	COG0778	Nitroreductase
CD200_11455	COG0400	carboxylic ester hydrolase activity
CD200_11465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CD200_11470	COG3409	Peptidoglycan-binding domain 1 protein
CD200_11470	COG0793	Belongs to the peptidase S41A family
CD200_11475	COG2226	methyltransferase
CD200_11485	COG1876	peptidase activity
CD200_11490	COG0813	purine-nucleoside phosphorylase activity
CD200_11495	COG0701	Predicted permease
CD200_11515	COG0671	phosphoesterase, PA-phosphatase related
CD200_11535	COG4479	Belongs to the UPF0346 family
CD200_11545	COG1509	lysine 2,3-aminomutase activity
CD200_11550	COG0456	acetyltransferase
CD200_11555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD200_11560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CD200_11565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CD200_11570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CD200_11585	COG0456	acetyltransferase
CD200_11590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CD200_11595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CD200_11600	COG1846	Transcriptional regulator
CD200_11610	COG3706	GGDEF domain
CD200_11615	COG0534	Mate efflux family protein
CD200_11630	COG4698	Protein conserved in bacteria
CD200_11635	COG2755	lipolytic protein G-D-S-L family
CD200_11640	COG1999	signal sequence binding
CD200_11655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CD200_11660	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CD200_11665	COG1272	protein, Hemolysin III
CD200_11670	COG0204	Acyl-transferase
CD200_11675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CD200_11685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CD200_11695	COG2136	Putative SAM-dependent methyltransferase
CD200_11695	COG2521	methyltransferase
CD200_11705	COG0129	dihydroxy-acid dehydratase activity
CD200_11710	COG1413	lyase activity
CD200_11715	COG1418	mRNA catabolic process
CD200_11720	COG0386	Belongs to the glutathione peroxidase family
CD200_11725	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CD200_11730	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CD200_11735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CD200_11745	COG1278	Cold shock
CD200_11765	COG0328	RNA-DNA hybrid ribonuclease activity
CD200_11770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CD200_11775	COG0328	RNA-DNA hybrid ribonuclease activity
CD200_11785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CD200_11800	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CD200_11810	COG1755	Isoprenylcysteine carboxyl methyltransferase
CD200_11815	COG3424	synthase
CD200_11820	COG0456	acetyltransferase
CD200_11825	COG2233	PERMEase
CD200_11830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CD200_11835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CD200_11840	COG1199	ATP-dependent helicase activity
CD200_11855	COG0116	Belongs to the methyltransferase superfamily
CD200_11865	COG3599	regulation of cell shape
CD200_11870	COG4474	Belongs to the UPF0398 family
CD200_11880	COG3359	exonuclease
CD200_11885	COG1111	helicase
CD200_11885	COG1205	dead DEAH box helicase
CD200_11890	COG2190	(PTS) system
CD200_11895	COG0071	Belongs to the small heat shock protein (HSP20) family
CD200_11935	COG3331	DNA recombination
CD200_11940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CD200_11940	COG4499	WXG100 protein secretion system (Wss), protein YukC
CD200_11950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CD200_11955	COG3935	DnaD domain protein
CD200_11960	COG0017	Asparaginyl-tRNA synthetase
CD200_11965	COG0436	Aminotransferase
CD200_11970	COG5353	protein conserved in bacteria
CD200_11980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CD200_11980	COG1199	ATP-dependent helicase activity
CD200_11985	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CD200_11990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CD200_11995	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CD200_12010	COG0617	tRNA 3'-terminal CCA addition
CD200_12015	COG0438	transferase activity, transferring glycosyl groups
CD200_12020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CD200_12025	COG1803	Methylglyoxal synthase
CD200_12030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CD200_12035	COG1694	Mazg nucleotide pyrophosphohydrolase
CD200_12040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD200_12050	COG4347	Protein of unknown function (DUF1405)
CD200_12055	COG2010	Cytochrome c
CD200_12055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CD200_12060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CD200_12065	COG0723	plastoquinol--plastocyanin reductase activity
CD200_12075	COG5582	Belongs to the UPF0302 family
CD200_12080	COG0457	Tetratricopeptide repeat
CD200_12085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CD200_12090	COG0287	Prephenate dehydrogenase
CD200_12095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CD200_12100	COG0159	tryptophan synthase activity
CD200_12105	COG0133	tryptophan synthase activity
CD200_12110	COG0135	phosphoribosylanthranilate isomerase activity
CD200_12115	COG0134	indole-3-glycerol-phosphate synthase activity
CD200_12120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CD200_12125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CD200_12130	COG4401	Chorismate mutase type I
CD200_12135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CD200_12140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CD200_12145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CD200_12150	COG0105	UTP biosynthetic process
CD200_12155	COG0142	geranyltranstransferase activity
CD200_12160	COG2226	methyltransferase
CD200_12165	COG0142	geranyltranstransferase activity
CD200_12180	COG0776	regulation of translation
CD200_12185	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CD200_12205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CD200_12210	COG1160	GTP binding
CD200_12235	COG1304	FMN binding
CD200_12240	COG0539	negative regulation of cytoplasmic translation
CD200_12245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CD200_12255	COG2959	enzyme of heme biosynthesis
CD200_12260	COG3773	Cell wall hydrolase
CD200_12260	COG3409	Peptidoglycan-binding domain 1 protein
CD200_12265	COG2339	peptidase activity
CD200_12275	COG0492	ferredoxin-NADP+ reductase activity
CD200_12280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CD200_12285	COG4862	establishment of competence for transformation
CD200_12290	COG1408	metallophosphoesterase
CD200_12300	COG1388	LysM domain
CD200_12305	COG1266	CAAX protease self-immunity
CD200_12310	COG0514	ATP-dependent DNA helicase (RecQ)
CD200_12315	COG4955	Helix-turn-helix domain
CD200_12320	COG1141	Ferredoxin
CD200_12325	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CD200_12330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CD200_12335	COG0739	heme binding
CD200_12345	COG1595	DNA-templated transcription, initiation
CD200_12365	COG5002	protein histidine kinase activity
CD200_12370	COG0745	RESPONSE REGULATOR receiver
CD200_12375	COG5002	protein histidine kinase activity
CD200_12380	COG0745	RESPONSE REGULATOR receiver
CD200_12385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CD200_12390	COG1333	cytochrome c biogenesis protein
CD200_12395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD200_12400	COG1187	pseudouridine synthase activity
CD200_12405	COG0700	Nucleoside recognition
CD200_12410	COG2715	membrane protein required for spore maturation
CD200_12415	COG1686	Belongs to the peptidase S11 family
CD200_12425	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CD200_12430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CD200_12440	COG1547	Domain of unknown function (DUF309)
CD200_12445	COG0456	acetyltransferase
CD200_12450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CD200_12455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CD200_12455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CD200_12460	COG0307	riboflavin synthase, alpha
CD200_12465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CD200_12465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CD200_12490	COG0457	Tetratricopeptide repeat
CD200_12495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CD200_12500	COG4086	secreted protein
CD200_12505	COG4195	phage-related replication protein
CD200_12510	COG0019	diaminopimelate decarboxylase activity
CD200_12520	COG0697	spore germination
CD200_12535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CD200_12570	COG1686	Belongs to the peptidase S11 family
CD200_12575	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CD200_12580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CD200_12585	COG4974	Belongs to the 'phage' integrase family
CD200_12595	COG0735	belongs to the Fur family
CD200_12600	COG1300	Membrane
CD200_12605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD200_12625	COG2153	protein acetylation
CD200_12630	COG1379	DNA repair
CD200_12635	COG0494	nUDIX hydrolase
CD200_12645	COG1309	transcriptional regulator
CD200_12655	COG0667	Aldo Keto reductase
CD200_12665	COG1073	alpha beta
CD200_12675	COG4918	Iron-sulphur cluster biosynthesis
CD200_12690	COG2329	Antibiotic biosynthesis monooxygenase
CD200_12700	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CD200_12710	COG0747	negative chemotaxis
CD200_12715	COG0601	transmembrane transport
CD200_12725	COG0444	Belongs to the ABC transporter superfamily
CD200_12735	COG0534	Mate efflux family protein
CD200_12750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CD200_12760	COG2211	Major facilitator Superfamily
CD200_12765	COG0346	lactoylglutathione lyase activity
CD200_12770	COG1072	(Pantothenic acid kinase))
CD200_12805	COG4195	phage-related replication protein
CD200_12815	COG0300	oxidoreductase activity
CD200_12820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD200_12825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CD200_12830	COG4187	Peptidase family M20/M25/M40
CD200_12835	COG1902	pentaerythritol trinitrate reductase activity
CD200_12840	COG0596	Alpha beta hydrolase
CD200_12845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CD200_12850	COG1234	tRNA 3'-trailer cleavage
CD200_12855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CD200_12875	COG2188	Transcriptional regulator
CD200_12880	COG2723	6-phospho-beta-galactosidase activity
CD200_12885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD200_12890	COG1447	Phosphotransferase system cellobiose-specific component IIA
CD200_12895	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD200_12900	COG1785	Belongs to the alkaline phosphatase family
CD200_12905	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_12910	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CD200_12915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CD200_12925	COG0706	membrane insertase activity
CD200_12930	COG2195	Cleaves the N-terminal amino acid of tripeptides
CD200_12935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CD200_12940	COG4129	membrane
CD200_12945	COG1126	abc transporter atp-binding protein
CD200_12950	COG0765	amino acid transport
CD200_12955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CD200_12965	COG1597	lipid kinase activity
CD200_12970	COG0508	dehydrogenase complex catalyzes the overall conversion of
CD200_12975	COG0022	dehydrogenase e1 component
CD200_12980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CD200_12985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CD200_12990	COG3426	butyrate kinase activity
CD200_13000	COG0280	phosphate acetyltransferase
CD200_13005	COG3829	transcription factor binding
CD200_13005	COG3290	protein histidine kinase activity
CD200_13015	COG0584	glycerophosphoryl diester phosphodiesterase
CD200_13020	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD200_13035	COG1045	serine acetyltransferase
CD200_13045	COG0745	RESPONSE REGULATOR receiver
CD200_13050	COG0750	zinc metalloprotease
CD200_13055	COG0497	DNA recombination
CD200_13060	COG1438	arginine binding
CD200_13065	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CD200_13070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CD200_13075	COG0142	geranyltranstransferase activity
CD200_13080	COG1722	exodeoxyribonuclease VII activity
CD200_13085	COG1570	exodeoxyribonuclease VII activity
CD200_13090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CD200_13095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CD200_13100	COG1302	Protein conserved in bacteria
CD200_13105	COG0439	Biotin carboxylase
CD200_13110	COG0511	ligase activity, forming carbon-carbon bonds
CD200_13150	COG3854	ATPases associated with a variety of cellular activities
CD200_13160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CD200_13165	COG0006	proline dipeptidase activity
CD200_13170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CD200_13180	COG3872	metal-dependent enzyme
CD200_13190	COG1752	Esterase of the alpha-beta hydrolase superfamily
CD200_13195	COG1321	iron dependent repressor
CD200_13200	COG0095	Lipoate-protein ligase
CD200_13205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CD200_13210	COG2113	Glycine betaine
CD200_13215	COG4176	ABC-type proline glycine betaine transport system permease component
CD200_13220	COG4175	Glycine betaine
CD200_13220	COG0517	IMP dehydrogenase activity
CD200_13225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CD200_13230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CD200_13235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CD200_13240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CD200_13265	COG0681	Belongs to the peptidase S26 family
CD200_13290	COG4940	Competence protein ComGF
CD200_13300	COG4970	Tfp pilus assembly protein FimT
CD200_13305	COG4537	Required for transformation and DNA binding
CD200_13310	COG1459	type II secretion system
CD200_13315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CD200_13320	COG1366	Belongs to the anti-sigma-factor antagonist family
CD200_13330	COG1393	Belongs to the ArsC family
CD200_13340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD200_13350	COG0011	TIGRFAM Protein of
CD200_13360	COG2866	Carboxypeptidase
CD200_13365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CD200_13370	COG1368	sulfuric ester hydrolase activity
CD200_13375	COG1940	carbohydrate kinase activity
CD200_13380	COG4483	Protein conserved in bacteria
CD200_13385	COG0697	spore germination
CD200_13390	COG0705	Rhomboid family
CD200_13390	COG0457	Tetratricopeptide repeat
CD200_13400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CD200_13405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CD200_13410	COG0438	transferase activity, transferring glycosyl groups
CD200_13425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CD200_13430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CD200_13435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CD200_13440	COG0581	inorganic phosphate transmembrane transporter activity
CD200_13445	COG0573	inorganic phosphate transmembrane transporter activity
CD200_13450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CD200_13460	COG0477	Major facilitator Superfamily
CD200_13465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CD200_13470	COG2839	Protein conserved in bacteria
CD200_13475	COG5521	maltodextrose utilization protein MalA
CD200_13480	COG1388	LysM domain
CD200_13485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CD200_13490	COG4709	membrane
CD200_13495	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CD200_13500	COG0735	belongs to the Fur family
CD200_13505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CD200_13510	COG1121	(ABC) transporter
CD200_13515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD200_13525	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CD200_13530	COG0513	Belongs to the DEAD box helicase family
CD200_13540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CD200_13545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CD200_13550	COG2384	SAM-dependent methyltransferase
CD200_13605	COG5444	nuclease activity
CD200_13620	COG2010	Cytochrome c
CD200_13625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CD200_13630	COG0358	DNA primase activity
CD200_13635	COG1671	Belongs to the UPF0178 family
CD200_13640	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CD200_13645	COG0517	IMP dehydrogenase activity
CD200_13650	COG0751	glycine-tRNA ligase activity
CD200_13655	COG0752	glycyl-tRNA synthetase alpha subunit
CD200_13660	COG1381	Involved in DNA repair and RecF pathway recombination
CD200_13670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CD200_13675	COG0295	cytidine deaminase activity
CD200_13680	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CD200_13685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CD200_13690	COG1480	7TM receptor with intracellular HD hydrolase
CD200_13695	COG1702	phosphate starvation-inducible protein PhoH
CD200_13700	COG0561	phosphatase activity
CD200_13715	COG4864	UPF0365 protein
CD200_13720	COG1030	water channel activity
CD200_13725	COG1610	YqeY-like protein
CD200_13730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CD200_13735	COG1283	sodium-dependent phosphate transmembrane transporter activity
CD200_13740	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CD200_13745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CD200_13750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CD200_13755	COG2264	protein methyltransferase activity
CD200_13760	COG0484	heat shock protein binding
CD200_13765	COG0443	Heat shock 70 kDa protein
CD200_13770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CD200_13775	COG1420	regulation of RNA biosynthetic process
CD200_13780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CD200_13785	COG0481	GTPase activity
CD200_13795	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD200_13800	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CD200_13805	COG0268	Binds directly to 16S ribosomal RNA
CD200_13810	COG1466	dna polymerase III delta subunit
CD200_13820	COG2333	competence protein COMEC
CD200_13820	COG0658	competence protein
CD200_13825	COG2131	deaminase
CD200_13830	COG1555	photosystem II stabilization
CD200_13830	COG1596	polysaccharide export
CD200_13835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CD200_13840	COG2226	methyltransferase
CD200_13845	COG0799	negative regulation of ribosome biogenesis
CD200_13850	COG1713	HD superfamily hydrolase involved in NAD metabolism
CD200_13855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CD200_13860	COG1534	Rna-binding protein
CD200_13865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CD200_13870	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CD200_13875	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CD200_13885	COG2755	lipolytic protein G-D-S-L family
CD200_13890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CD200_13895	COG5609	conserved protein (DUF2294)
CD200_13900	COG3383	formate dehydrogenase (NAD+) activity
CD200_13905	COG2427	Protein of unknown function (DUF1641)
CD200_13940	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD200_13985	COG1136	(ABC) transporter
CD200_13990	COG0577	efflux transmembrane transporter activity
CD200_14075	COG2197	response regulator
CD200_14080	COG4585	Histidine kinase
CD200_14085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD200_14090	COG0730	response to heat
CD200_14095	COG0425	Belongs to the sulfur carrier protein TusA family
CD200_14105	COG0425	Belongs to the sulfur carrier protein TusA family
CD200_14105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CD200_14110	COG2210	Belongs to the sulfur carrier protein TusA family
CD200_14115	COG1937	Protein conserved in bacteria
CD200_14155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CD200_14160	COG0113	porphobilinogen synthase activity
CD200_14165	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CD200_14170	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CD200_14175	COG1733	regulation of RNA biosynthetic process
CD200_14180	COG3239	Fatty acid desaturase
CD200_14185	COG4585	Histidine kinase
CD200_14190	COG2197	response regulator
CD200_14195	COG0492	ferredoxin-NADP+ reductase activity
CD200_14200	COG0747	negative chemotaxis
CD200_14205	COG0601	transmembrane transport
CD200_14215	COG0444	Belongs to the ABC transporter superfamily
CD200_14220	COG4608	Belongs to the ABC transporter superfamily
CD200_14240	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_14255	COG2124	cytochrome p450
CD200_14260	COG0730	response to heat
CD200_14275	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_14285	COG3716	PTS system mannose fructose sorbose family IID component
CD200_14290	COG3715	PTS system
CD200_14295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_14300	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD200_14305	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CD200_14305	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CD200_14330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CD200_14335	COG0656	L-ascorbic acid biosynthetic process
CD200_14340	COG2814	Major facilitator Superfamily
CD200_14345	COG1733	regulation of RNA biosynthetic process
CD200_14350	COG3340	Belongs to the peptidase S51 family
CD200_14355	COG1587	Uroporphyrinogen-III synthase
CD200_14365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CD200_14370	COG0583	DNA-binding transcription factor activity
CD200_14375	COG2814	Major facilitator Superfamily
CD200_14385	COG2124	cytochrome p450
CD200_14385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CD200_14390	COG1309	transcriptional regulator
CD200_14395	COG1404	Belongs to the peptidase S8 family
CD200_14400	COG2226	methyltransferase
CD200_14425	COG0626	cystathionine gamma-synthase activity
CD200_14430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CD200_14435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CD200_14440	COG2226	methyltransferase
CD200_14455	COG0768	penicillin binding
CD200_14460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CD200_14465	COG0572	uridine kinase
CD200_14485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CD200_14490	COG3906	Belongs to the UPF0473 family
CD200_14495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CD200_14500	COG4472	Bacterial protein of unknown function (DUF965)
CD200_14505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CD200_14510	COG0628	permease
CD200_14525	COG3881	PFAM PRC-barrel domain
CD200_14530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CD200_14535	COG0457	Tetratricopeptide repeat
CD200_14540	COG0482	sulfurtransferase activity
CD200_14545	COG1104	cysteine desulfurase activity
CD200_14550	COG1959	2 iron, 2 sulfur cluster binding
CD200_14555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CD200_14560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CD200_14570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CD200_14575	COG0124	histidyl-tRNA synthetase
CD200_14585	COG4991	sh3 domain protein
CD200_14585	COG3103	Sh3 type 3 domain protein
CD200_14585	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD200_14590	COG1490	D-aminoacyl-tRNA deacylase activity
CD200_14595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CD200_14600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CD200_14605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CD200_14605	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CD200_14610	COG5416	Lipopolysaccharide assembly protein A domain
CD200_14615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CD200_14615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CD200_14625	COG2244	polysaccharide biosynthetic process
CD200_14630	COG2323	membrane
CD200_14640	COG1862	Preprotein translocase
CD200_14645	COG0343	queuine tRNA-ribosyltransferase activity
CD200_14650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CD200_14660	COG2255	four-way junction helicase activity
CD200_14665	COG0632	four-way junction helicase activity
CD200_14675	COG2112	serine threonine protein kinase
CD200_14685	COG2318	DinB family
CD200_14690	COG4195	phage-related replication protein
CD200_14705	COG0217	transcriptional regulatory protein
CD200_14715	COG1388	LysM domain
CD200_14720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CD200_14725	COG0157	Belongs to the NadC ModD family
CD200_14730	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CD200_14735	COG1104	cysteine desulfurase activity
CD200_14740	COG1827	regulation of RNA biosynthetic process
CD200_14745	COG0077	Prephenate dehydratase
CD200_14750	COG4492	Belongs to the UPF0735 family
CD200_14755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CD200_14760	COG3290	protein histidine kinase activity
CD200_14765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CD200_14770	COG2868	ribosomal protein
CD200_14775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CD200_14780	COG1994	Peptidase M50
CD200_14785	COG0739	heme binding
CD200_14790	COG3832	glyoxalase III activity
CD200_14795	COG0640	Transcriptional regulator
CD200_14800	COG2894	cell division
CD200_14805	COG0850	regulation of cytokinetic process
CD200_14810	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CD200_14815	COG1792	Involved in formation and maintenance of cell shape
CD200_14820	COG1077	Cell shape determining protein MreB Mrl
CD200_14825	COG2003	Belongs to the UPF0758 family
CD200_14830	COG0424	maF-like protein
CD200_14840	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CD200_14845	COG0285	dihydrofolate synthase activity
CD200_14850	COG0525	valine-tRNA ligase activity
CD200_14860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CD200_14865	COG1388	LysM domain
CD200_14870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CD200_14875	COG0113	porphobilinogen synthase activity
CD200_14880	COG1587	Uroporphyrinogen-III synthase
CD200_14885	COG0181	hydroxymethylbilane synthase activity
CD200_14890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CD200_14895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CD200_14905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CD200_14910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CD200_14915	COG1067	ATP-dependent peptidase activity
CD200_14915	COG0470	DNA polymerase III
CD200_14920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CD200_14925	COG0544	peptidyl-prolyl cis-trans isomerase activity
CD200_14930	COG0457	Tetratricopeptide repeat
CD200_14930	COG1477	protein flavinylation
CD200_14935	COG0066	3-isopropylmalate dehydratase activity
CD200_14940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CD200_14945	COG0473	3-isopropylmalate dehydrogenase activity
CD200_14950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CD200_14955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CD200_14960	COG0440	acetolactate synthase activity
CD200_14965	COG0028	Belongs to the TPP enzyme family
CD200_14970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CD200_15000	COG5518	Phage portal protein
CD200_15005	COG1783	phage Terminase large subunit
CD200_15040	COG5444	nuclease activity
CD200_15045	COG0457	Tetratricopeptide repeat
CD200_15065	COG0622	Phosphoesterase
CD200_15070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CD200_15075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CD200_15080	COG5401	PFAM Sporulation and spore germination
CD200_15085	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CD200_15090	COG1846	Transcriptional regulator
CD200_15095	COG2197	response regulator
CD200_15100	COG4221	oxidoreductase activity
CD200_15105	COG0824	Thioesterase
CD200_15110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CD200_15115	COG1053	succinate dehydrogenase
CD200_15120	COG2009	succinate dehydrogenase
CD200_15125	COG1719	4-vinyl reductase, 4VR
CD200_15130	COG0527	aspartate kinase activity
CD200_15135	COG0322	excinuclease ABC activity
CD200_15140	COG3118	belongs to the thioredoxin family
CD200_15145	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CD200_15150	COG2086	electron transfer activity
CD200_15155	COG1024	Enoyl-CoA hydratase
CD200_15160	COG1309	transcriptional regulator
CD200_15165	COG0318	PFAM AMP-dependent synthetase and ligase
CD200_15170	COG3766	membrane
CD200_15175	COG1193	negative regulation of DNA recombination
CD200_15180	COG1796	DNA polymerase
CD200_15180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CD200_15185	COG1286	toxin biosynthetic process
CD200_15190	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CD200_15195	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CD200_15225	COG1137	ATPase activity
CD200_15240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CD200_15240	COG0072	phenylalanine-tRNA ligase activity
CD200_15245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CD200_15250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CD200_15260	COG1966	Carbon starvation protein
CD200_15275	COG0395	ABC-type sugar transport system, permease component
CD200_15280	COG1175	transmembrane transport
CD200_15285	COG1653	transport
CD200_15290	COG0371	Dehydrogenase
CD200_15295	COG0235	Class ii aldolase
CD200_15300	COG1069	ribulokinase activity
CD200_15305	COG2160	L-arabinose isomerase activity
CD200_15310	COG3507	Belongs to the glycosyl hydrolase 43 family
CD200_15315	COG1363	Peptidase, m42
CD200_15325	COG3326	Membrane
CD200_15330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CD200_15335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CD200_15340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CD200_15345	COG1346	cytolysis
CD200_15355	COG3540	Alkaline phosphatase
CD200_15360	COG3279	Response regulator of the LytR AlgR family
CD200_15365	COG3275	phosphorelay sensor kinase activity
CD200_15380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CD200_15390	COG0398	Pfam SNARE associated Golgi protein
CD200_15395	COG1484	DNA-dependent DNA replication
CD200_15400	COG3611	Membrane attachment protein
CD200_15405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CD200_15420	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CD200_15425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CD200_15430	COG3866	Pectate lyase
CD200_15435	COG0237	dephospho-CoA kinase activity
CD200_15440	COG1971	Probably functions as a manganese efflux pump
CD200_15445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CD200_15450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CD200_15450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CD200_15455	COG5002	protein histidine kinase activity
CD200_15460	COG0745	RESPONSE REGULATOR receiver
CD200_15465	COG0039	L-malate dehydrogenase activity
CD200_15470	COG0538	isocitrate dehydrogenase activity
CD200_15475	COG0372	Belongs to the citrate synthase family
CD200_15480	COG2707	UPF0756 membrane protein
CD200_15485	COG0628	permease
CD200_15490	COG3030	protein affecting phage T7 exclusion by the F plasmid
CD200_15500	COG0205	6-phosphofructokinase activity
CD200_15505	COG0825	malonyl-CoA metabolic process
CD200_15510	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CD200_15515	COG0281	malic enzyme
CD200_15520	COG0587	DNA-directed DNA polymerase activity
CD200_15540	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CD200_15550	COG4109	DRTGG domain
CD200_15555	COG1695	Transcriptional regulator
CD200_15560	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CD200_15565	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_15570	COG0165	Argininosuccinate lyase
CD200_15575	COG0137	argininosuccinate synthase activity
CD200_15580	COG0521	Mo-molybdopterin cofactor biosynthetic process
CD200_15585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CD200_15590	COG0827	DNA restriction-modification system
CD200_15595	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CD200_15600	COG3874	Sporulation protein YtfJ
CD200_15610	COG1714	RDD family
CD200_15615	COG0616	signal peptide processing
CD200_15620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CD200_15625	COG1566	PFAM secretion protein HlyD family protein
CD200_15630	COG0477	Major facilitator Superfamily
CD200_15640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CD200_15650	COG0301	tRNA thio-modification
CD200_15655	COG1104	cysteine desulfurase activity
CD200_15660	COG1114	Component of the transport system for branched-chain amino acids
CD200_15665	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CD200_15670	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CD200_15675	COG1309	transcriptional regulator
CD200_15680	COG1956	GAF domain-containing protein
CD200_15685	COG2199	diguanylate cyclase activity
CD200_15685	COG2203	Gaf domain
CD200_15695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CD200_15710	COG3152	Membrane
CD200_15715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CD200_15720	COG1522	sequence-specific DNA binding
CD200_15725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CD200_15730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CD200_15735	COG0454	-acetyltransferase
CD200_15740	COG0517	IMP dehydrogenase activity
CD200_15745	COG0123	including yeast histone deacetylase and acetoin utilization protein
CD200_15750	COG1360	Flagellar Motor Protein
CD200_15755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CD200_15760	COG1609	Transcriptional regulator
CD200_15765	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CD200_15765	COG1605	Chorismate mutase
CD200_15775	COG3118	belongs to the thioredoxin family
CD200_15780	COG4980	gas vesicle protein
CD200_15785	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CD200_15790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CD200_15795	COG1674	ftsk spoiiie
CD200_15800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CD200_15805	COG4848	Belongs to the UPF0354 family
CD200_15810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD200_15820	COG1363	Peptidase, m42
CD200_15825	COG5584	Small secreted protein
CD200_15830	COG0281	malic enzyme
CD200_15835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CD200_15840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CD200_15850	COG0510	thiamine kinase activity
CD200_15855	COG1523	belongs to the glycosyl hydrolase 13 family
CD200_15860	COG1597	lipid kinase activity
CD200_15870	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CD200_15875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CD200_15890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD200_15895	COG2252	PERMEase
CD200_15900	COG1349	DNA-binding transcription factor activity
CD200_15905	COG1187	pseudouridine synthase activity
CD200_15910	COG2244	polysaccharide biosynthetic process
CD200_15915	COG2081	HI0933 family
CD200_15920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CD200_15930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CD200_15945	COG5578	integral membrane protein
CD200_15950	COG0673	inositol 2-dehydrogenase activity
CD200_15955	COG1653	transport
CD200_15960	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CD200_15965	COG4209	transmembrane transport
CD200_15970	COG2207	Transcriptional regulator
CD200_15975	COG1653	transport
CD200_15980	COG0395	ABC-type sugar transport system, permease component
CD200_15985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CD200_15990	COG1073	alpha beta
CD200_16000	COG0583	DNA-binding transcription factor activity
CD200_16005	COG0346	lactoylglutathione lyase activity
CD200_16010	COG0495	leucyl-tRNA aminoacylation
CD200_16020	COG2814	Major facilitator Superfamily
CD200_16030	COG2433	Pfam Transposase IS66
CD200_16035	COG0577	efflux transmembrane transporter activity
CD200_16040	COG1136	(ABC) transporter
CD200_16050	COG1131	(ABC) transporter
CD200_16055	COG1725	Transcriptional regulator
CD200_16065	COG1242	4 iron, 4 sulfur cluster binding
CD200_16070	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CD200_16075	COG1301	dicarboxylic acid transport
CD200_16085	COG2267	carboxylic ester hydrolase activity
CD200_16090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CD200_16095	COG0671	phosphoesterase, PA-phosphatase related
CD200_16100	COG0438	transferase activity, transferring glycosyl groups
CD200_16100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CD200_16105	COG0367	asparagine synthase
CD200_16110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CD200_16115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CD200_16130	COG1506	peptidase
CD200_16135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CD200_16140	COG1116	anion transmembrane transporter activity
CD200_16145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CD200_16150	COG0494	nUDIX hydrolase
CD200_16160	COG4824	toxin secretion phage lysis holin
CD200_16165	COG0783	Belongs to the Dps family
CD200_16180	COG1854	S-ribosylhomocysteine lyase activity
CD200_16185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CD200_16190	COG0288	reversible hydration of carbon dioxide
CD200_16195	COG0523	cobalamin synthesis protein
CD200_16200	COG0803	Belongs to the bacterial solute-binding protein 9 family
CD200_16205	COG0254	rRNA binding
CD200_16210	COG1271	oxidase subunit
CD200_16215	COG1294	oxidase, subunit
CD200_16230	COG4948	Mandelate Racemase Muconate Lactonizing
CD200_16235	COG0318	PFAM AMP-dependent synthetase and ligase
CD200_16240	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CD200_16245	COG0596	Alpha beta hydrolase
CD200_16250	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CD200_16255	COG1169	isochorismate synthase
CD200_16260	COG1575	Belongs to the MenA family. Type 1 subfamily
CD200_16265	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CD200_16280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CD200_16285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CD200_16290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CD200_16415	COG1609	Transcriptional regulator
CD200_16420	COG3859	Proton-coupled thiamine transporter YuaJ
CD200_16425	COG3764	Sortase (surface protein transpeptidase)
CD200_16440	COG0457	Tetratricopeptide repeat
CD200_16445	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CD200_16450	COG0569	domain protein
CD200_16455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CD200_16465	COG2318	DinB family
CD200_16475	COG1454	alcohol dehydrogenase
CD200_16485	COG1510	regulation of RNA biosynthetic process
CD200_16495	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CD200_16500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CD200_16505	COG2140	Oxalate decarboxylase
CD200_16535	COG1397	ADP-ribosylglycohydrolase
CD200_16570	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CD200_16580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CD200_16585	COG0726	polysaccharide deacetylase
CD200_16590	COG1408	metallophosphoesterase
CD200_16595	COG1968	undecaprenyl-diphosphatase activity
CD200_16600	COG0628	permease
CD200_16605	COG0673	inositol 2-dehydrogenase activity
CD200_16610	COG0693	protein deglycase activity
CD200_16615	COG0840	transmembrane signaling receptor activity
CD200_16620	COG0840	transmembrane signaling receptor activity
CD200_16625	COG0840	transmembrane signaling receptor activity
CD200_16635	COG2070	2-Nitropropane dioxygenase
CD200_16640	COG0432	Pfam Uncharacterised protein family UPF0047
CD200_16645	COG0366	Alpha amylase catalytic
CD200_16660	COG5297	Belongs to the glycosyl hydrolase family 6
CD200_16665	COG1253	flavin adenine dinucleotide binding
CD200_16670	COG2738	Putative neutral zinc metallopeptidase
CD200_16685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CD200_16695	COG2323	membrane
CD200_16700	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CD200_16710	COG0166	Belongs to the GPI family
CD200_16715	COG1979	alcohol dehydrogenase
CD200_16720	COG2155	Conserved Protein
CD200_16725	COG1098	S1 RNA binding domain
CD200_16730	COG0436	Aminotransferase
CD200_16735	COG1522	sequence-specific DNA binding
CD200_16740	COG2267	carboxylic ester hydrolase activity
CD200_16755	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CD200_16770	COG5018	Exonuclease
CD200_16775	COG2814	Major facilitator Superfamily
CD200_16780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CD200_16785	COG3011	Protein conserved in bacteria
CD200_16795	COG3290	protein histidine kinase activity
CD200_16800	COG4565	transcriptional regulatory protein
CD200_16810	COG1183	phosphatidylcholine synthase activity
CD200_16815	COG0586	Pfam SNARE associated Golgi protein
CD200_16820	COG0688	phosphatidylethanolamine metabolic process
CD200_16825	COG3493	citrate carrier protein
CD200_16835	COG2111	Na H antiporter
CD200_16835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CD200_16840	COG2111	Na H antiporter
CD200_16845	COG1006	Multisubunit Na H antiporter MnhC subunit
CD200_16850	COG0651	ATP synthesis coupled electron transport
CD200_16855	COG1863	multisubunit Na H antiporter MnhE subunit
CD200_16860	COG2212	antiporter activity
CD200_16865	COG1320	monovalent cation:proton antiporter activity
CD200_16870	COG2050	protein possibly involved in aromatic compounds catabolism
CD200_16875	COG2197	response regulator
CD200_16880	COG4585	Histidine kinase
CD200_16910	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CD200_16915	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CD200_16920	COG1335	isochorismatase
CD200_16925	COG5506	Protein of unknown function (DUF1694)
CD200_16940	COG0628	permease
CD200_16945	COG1959	2 iron, 2 sulfur cluster binding
CD200_16960	COG1418	mRNA catabolic process
CD200_16965	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_16975	COG1511	domain protein
CD200_16980	COG0433	COG0433 Predicted ATPase
CD200_16980	COG1674	ftsk spoiiie
CD200_16985	COG4499	WXG100 protein secretion system (Wss), protein YukC
CD200_16990	COG5417	Belongs to the EsaB family
CD200_16995	COG4842	Belongs to the WXG100 family
CD200_17000	COG1115	amino acid carrier protein
CD200_17005	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CD200_17005	COG2508	Transcriptional regulator
CD200_17010	COG0686	Belongs to the AlaDH PNT family
CD200_17020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CD200_17025	COG1268	BioY protein
CD200_17030	COG2056	Na+-H+ antiporter family
CD200_17035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CD200_17040	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CD200_17045	COG3584	3D domain protein
CD200_17055	COG1252	NADH dehydrogenase
CD200_17060	COG0492	ferredoxin-NADP+ reductase activity
CD200_17075	COG0456	acetyltransferase
CD200_17080	COG0316	Belongs to the HesB IscA family
CD200_17085	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CD200_17090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CD200_17095	COG4844	belongs to the
CD200_17100	COG1252	NADH dehydrogenase
CD200_17105	COG5646	InterPro IPR014922
CD200_17115	COG0457	Tetratricopeptide repeat
CD200_17120	COG3479	Phenolic acid decarboxylase
CD200_17130	COG4837	Protein of unknown function (DUF1462)
CD200_17135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CD200_17140	COG4946	Tricorn protease homolog
CD200_17140	COG0823	Involved in the tonB-independent uptake of proteins
CD200_17140	COG1506	peptidase
CD200_17145	COG0083	homoserine kinase activity
CD200_17150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CD200_17155	COG0460	homoserine dehydrogenase
CD200_17165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CD200_17170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CD200_17175	COG0647	UMP catabolic process
CD200_17180	COG2445	Protein of unknown function DUF86
CD200_17185	COG4470	Protein conserved in bacteria
CD200_17200	COG0739	heme binding
CD200_17210	COG0733	neurotransmitter:sodium symporter activity
CD200_17220	COG3377	Domain of unknown function (DUF1805)
CD200_17225	COG0737	Belongs to the 5'-nucleotidase family
CD200_17230	COG0730	response to heat
CD200_17235	COG1801	Protein of unknown function DUF72
CD200_17245	COG3226	Transcriptional regulator
CD200_17255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CD200_17260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CD200_17265	COG2508	Transcriptional regulator
CD200_17270	COG2814	Major facilitator Superfamily
CD200_17275	COG1288	antiporter activity
CD200_17280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CD200_17290	COG2356	endonuclease I
CD200_17300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CD200_17315	COG0457	Tetratricopeptide repeat
CD200_17320	COG0719	Fe-S assembly protein
CD200_17325	COG0822	iron-sulfur transferase activity
CD200_17330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CD200_17335	COG0719	Fe-S assembly protein
CD200_17340	COG0396	ATPase activity
CD200_17350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CD200_17355	COG1464	Belongs to the NlpA lipoprotein family
CD200_17360	COG2011	ABC-type metal ion transport system permease component
CD200_17365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CD200_17375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CD200_17380	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CD200_17390	COG0509	glycine decarboxylation via glycine cleavage system
CD200_17395	COG1393	Belongs to the ArsC family
CD200_17400	COG1960	acyl-CoA dehydrogenase activity
CD200_17405	COG0183	Belongs to the thiolase family
CD200_17410	COG1250	3-hydroxyacyl-CoA dehydrogenase
CD200_17410	COG1024	Enoyl-CoA hydratase
CD200_17425	COG5577	PFAM Coat F domain
CD200_17440	COG1120	ATPase activity
CD200_17445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD200_17450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD200_17455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CD200_17470	COG1686	Belongs to the peptidase S11 family
CD200_17475	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_17480	COG0783	Belongs to the Dps family
CD200_17485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CD200_17490	COG0745	RESPONSE REGULATOR receiver
CD200_17495	COG2205	protein histidine kinase activity
CD200_17495	COG2770	Histidine kinase
CD200_17505	COG1309	transcriptional regulator
CD200_17510	COG0114	fumarate hydratase activity
CD200_17520	COG0697	spore germination
CD200_17525	COG0814	amino acid
CD200_17540	COG2197	response regulator
CD200_17545	COG4585	Histidine kinase
CD200_17550	COG4758	membrane
CD200_17560	COG1842	Phage shock protein A
CD200_17565	COG4758	membrane
CD200_17570	COG4677	pectinesterase activity
CD200_17575	COG2096	Adenosyltransferase
CD200_17580	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_17600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD200_17605	COG1120	ATPase activity
CD200_17610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD200_17615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CD200_17620	COG1802	Transcriptional regulator
CD200_17625	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_17630	COG2258	MOSC domain
CD200_17635	COG0583	DNA-binding transcription factor activity
CD200_17645	COG2721	sulfolactate sulfo-lyase activity
CD200_17650	COG0246	Mannitol dehydrogenase
CD200_17655	COG1609	Transcriptional regulator
CD200_17660	COG2211	Major facilitator Superfamily
CD200_17665	COG1904	glucuronate isomerase
CD200_17670	COG2205	protein histidine kinase activity
CD200_17675	COG0745	RESPONSE REGULATOR receiver
CD200_17680	COG1120	ATPase activity
CD200_17685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD200_17690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD200_17695	COG0531	amino acid
CD200_17705	COG1988	membrane-bound metal-dependent
CD200_17710	COG1368	sulfuric ester hydrolase activity
CD200_17715	COG2814	Major facilitator Superfamily
CD200_17720	COG0656	L-ascorbic acid biosynthetic process
CD200_17725	COG1940	carbohydrate kinase activity
CD200_17730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CD200_17740	COG3973	AAA domain
CD200_17745	COG2860	membrane
CD200_17750	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CD200_17750	COG0456	acetyltransferase
CD200_17755	COG0456	acetyltransferase
CD200_17760	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CD200_17765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CD200_17770	COG2217	Heavy metal translocating P-type atpase
CD200_17775	COG1653	transport
CD200_17780	COG1175	transmembrane transport
CD200_17785	COG0395	ABC-type sugar transport system, permease component
CD200_17790	COG1501	Belongs to the glycosyl hydrolase 31 family
CD200_17795	COG1472	Belongs to the glycosyl hydrolase 3 family
CD200_17800	COG1121	(ABC) transporter
CD200_17805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CD200_17810	COG0803	Belongs to the bacterial solute-binding protein 9 family
CD200_17830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD200_17830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD200_17830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CD200_17845	COG2217	Heavy metal translocating P-type atpase
CD200_17850	COG2608	mercury ion transmembrane transporter activity
CD200_17855	COG1937	Protein conserved in bacteria
CD200_17860	COG0693	protein deglycase activity
CD200_17865	COG1349	DNA-binding transcription factor activity
CD200_17870	COG1070	Carbohydrate kinase
CD200_17875	COG4952	isomerase
CD200_17885	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_17885	COG3347	Dehydrogenase
CD200_17895	COG2814	Major facilitator Superfamily
CD200_17905	COG2124	cytochrome p450
CD200_17915	COG1846	Transcriptional regulator
CD200_17925	COG0673	inositol 2-dehydrogenase activity
CD200_17930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CD200_17945	COG1191	sigma factor activity
CD200_17955	COG2140	Oxalate decarboxylase
CD200_18005	COG2323	membrane
CD200_18010	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CD200_18015	COG0662	Cupin 2, conserved barrel domain protein
CD200_18055	COG1705	Flagellar rod assembly protein muramidase FlgJ
CD200_18065	COG5280	Phage tail tape measure protein TP901
CD200_18065	COG3953	SLT domain
CD200_18125	COG4626	Terminase
CD200_18125	COG1802	Transcriptional regulator
CD200_18155	COG0758	DNA mediated transformation
CD200_18275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CD200_18280	COG0557	exoribonuclease II activity
CD200_18285	COG1647	Serine aminopeptidase, S33
CD200_18290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CD200_18295	COG2002	toxin-antitoxin pair type II binding
CD200_18300	COG1476	TRANSCRIPTIONal
CD200_18305	COG1396	sequence-specific DNA binding
CD200_18310	COG1396	sequence-specific DNA binding
CD200_18315	COG1174	glycine betaine transport
CD200_18320	COG1732	Glycine betaine
CD200_18325	COG1174	glycine betaine transport
CD200_18330	COG1125	glycine betaine transport
CD200_18330	COG0517	IMP dehydrogenase activity
CD200_18335	COG1510	regulation of RNA biosynthetic process
CD200_18340	COG2095	MarC family integral membrane protein
CD200_18355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CD200_18365	COG0693	protein deglycase activity
CD200_18370	COG0148	phosphopyruvate hydratase activity
CD200_18375	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CD200_18380	COG0149	triose-phosphate isomerase activity
CD200_18385	COG0126	phosphoglycerate kinase activity
CD200_18390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CD200_18395	COG2390	Transcriptional regulator
CD200_18400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CD200_18405	COG1113	amino acid transport
CD200_18425	COG1556	Lactate utilization protein
CD200_18430	COG1139	Iron-sulfur cluster binding protein
CD200_18435	COG0247	lactate metabolic process
CD200_18440	COG2186	Transcriptional regulator
CD200_18445	COG1620	l-lactate permease
CD200_18450	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CD200_18460	COG5039	Polysaccharide pyruvyl transferase
CD200_18465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CD200_18470	COG0110	maltose O-acetyltransferase activity
CD200_18475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CD200_18480	COG2244	polysaccharide biosynthetic process
CD200_18485	COG1216	Glycosyl transferase, family 2
CD200_18490	COG5039	Polysaccharide pyruvyl transferase
CD200_18495	COG1216	Glycosyl transferase, family 2
CD200_18505	COG0438	transferase activity, transferring glycosyl groups
CD200_18510	COG1215	transferase activity, transferring glycosyl groups
CD200_18515	COG0438	transferase activity, transferring glycosyl groups
CD200_18520	COG1086	Polysaccharide biosynthesis protein
CD200_18525	COG0489	protein tyrosine kinase activity
CD200_18530	COG3944	biosynthesis protein
CD200_18535	COG1396	sequence-specific DNA binding
CD200_18540	COG2249	NAD(P)H dehydrogenase (quinone) activity
CD200_18545	COG2271	Major facilitator Superfamily
CD200_18555	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CD200_18570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CD200_18580	COG1733	regulation of RNA biosynthetic process
CD200_18585	COG1902	pentaerythritol trinitrate reductase activity
CD200_18590	COG1621	beta-fructofuranosidase activity
CD200_18595	COG1621	beta-fructofuranosidase activity
CD200_18610	COG0740	serine-type endopeptidase activity
CD200_18615	COG1611	Belongs to the LOG family
CD200_18620	COG1694	Mazg nucleotide pyrophosphohydrolase
CD200_18630	COG0659	secondary active sulfate transmembrane transporter activity
CD200_18635	COG0288	reversible hydration of carbon dioxide
CD200_18640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CD200_18645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CD200_18650	COG0640	Transcriptional regulator
CD200_18660	COG2732	(Barnase) inhibitor
CD200_18665	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CD200_18670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD200_18675	COG1481	regulation of sporulation
CD200_18680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CD200_18685	COG1660	Displays ATPase and GTPase activities
CD200_18690	COG1051	belongs to the nudix hydrolase family
CD200_18700	COG0492	ferredoxin-NADP+ reductase activity
CD200_18705	COG0457	Tetratricopeptide repeat
CD200_18710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CD200_18715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CD200_18715	COG0140	phosphoribosyl-ATP diphosphatase activity
CD200_18720	COG0107	imidazoleglycerol-phosphate synthase activity
CD200_18725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CD200_18730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CD200_18735	COG0131	Imidazoleglycerol-phosphate dehydratase
CD200_18740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CD200_18745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CD200_18750	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CD200_18755	COG4990	cell redox homeostasis
CD200_18760	COG5297	Belongs to the glycosyl hydrolase family 6
CD200_18765	COG0110	maltose O-acetyltransferase activity
CD200_18770	COG0546	phosphoglycolate phosphatase activity
CD200_18775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CD200_18780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CD200_18785	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CD200_18790	COG1846	Transcriptional regulator
CD200_18795	COG2814	Major facilitator Superfamily
CD200_18800	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CD200_18805	COG1950	PFAM Membrane protein of
CD200_18810	COG1983	PspC domain protein
CD200_18815	COG3595	metallopeptidase activity
CD200_18840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CD200_18845	COG0556	nucleotide-excision repair
CD200_18850	COG4897	Protein conserved in bacteria
CD200_18860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CD200_18870	COG3409	Peptidoglycan-binding domain 1 protein
CD200_18870	COG0793	Belongs to the peptidase S41A family
CD200_18875	COG0473	3-isopropylmalate dehydrogenase activity
CD200_18880	COG3883	PFAM NLP P60 protein
CD200_18880	COG0791	NLP P60 protein
CD200_18885	COG2177	Part of the ABC transporter FtsEX involved in
CD200_18890	COG2884	Cell division ATP-binding protein ftsE
CD200_18900	COG2010	Cytochrome c
CD200_18905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD200_18915	COG0653	protein targeting
CD200_18920	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CD200_18935	COG1516	flagellar protein fliS
CD200_18940	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CD200_18945	COG1334	flagellar protein FlaG
CD200_18955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CD200_18960	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CD200_18965	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CD200_18975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CD200_18980	COG1256	bacterial-type flagellum assembly
CD200_18980	COG4786	Flagellar basal body rod
CD200_18985	COG3418	PFAM FlgN family protein
CD200_18990	COG2747	anti-sigma28 factor FlgM
CD200_19000	COG1040	competence protein
CD200_19010	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CD200_19015	COG1307	EDD domain protein, DegV family
CD200_19020	COG4585	Histidine kinase
CD200_19025	COG1739	Uncharacterized protein family UPF0029
CD200_19030	COG1316	TRANSCRIPTIONal
CD200_19040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CD200_19045	COG0438	transferase activity, transferring glycosyl groups
CD200_19050	COG1215	transferase activity, transferring glycosyl groups
CD200_19055	COG3206	protein involved in exopolysaccharide biosynthesis
CD200_19060	COG3307	-O-antigen
CD200_19065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CD200_19070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CD200_19075	COG0297	glycogen (starch) synthase activity
CD200_19075	COG0438	transferase activity, transferring glycosyl groups
CD200_19080	COG2244	polysaccharide biosynthetic process
CD200_19090	COG2247	cell wall binding repeat
CD200_19090	COG0860	N-Acetylmuramoyl-L-alanine amidase
CD200_19095	COG2247	cell wall binding repeat
CD200_19095	COG2385	sporulation resulting in formation of a cellular spore
CD200_19105	COG1316	TRANSCRIPTIONal
CD200_19110	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CD200_19115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CD200_19120	COG1134	teichoic acid transport
CD200_19125	COG1682	transport, permease protein
CD200_19140	COG0463	Glycosyl transferase, family 2
CD200_19140	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CD200_19145	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CD200_19150	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CD200_19155	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CD200_19160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CD200_19165	COG4193	domain, Protein
CD200_19170	COG1482	cell wall glycoprotein biosynthetic process
CD200_19190	COG0800	Aldolase
CD200_19195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CD200_19200	COG1609	Transcriptional regulator
CD200_19205	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CD200_19210	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_19215	COG1063	alcohol dehydrogenase
CD200_19220	COG2814	Major facilitator Superfamily
CD200_19225	COG1316	TRANSCRIPTIONal
CD200_19230	COG0561	phosphatase activity
CD200_19235	COG0791	NLP P60 protein
CD200_19245	COG2843	Capsule synthesis protein
CD200_19255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CD200_19260	COG1609	Transcriptional regulator
CD200_19265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CD200_19270	COG1869	D-ribose catabolic process
CD200_19275	COG1129	ABC transporter
CD200_19280	COG1172	Belongs to the binding-protein-dependent transport system permease family
CD200_19285	COG1879	ABC-type sugar transport system periplasmic component
CD200_19295	COG3527	Alpha-acetolactate decarboxylase
CD200_19300	COG0028	Belongs to the TPP enzyme family
CD200_19305	COG0583	DNA-binding transcription factor activity
CD200_19320	COG1522	sequence-specific DNA binding
CD200_19330	COG2059	Chromate
CD200_19335	COG4464	protein tyrosine phosphatase activity
CD200_19340	COG3944	biosynthesis protein
CD200_19350	COG4715	Zinc finger, swim domain protein
CD200_19355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CD200_19360	COG0561	phosphatase activity
CD200_19365	COG1349	DNA-binding transcription factor activity
CD200_19375	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_19385	COG3732	PTS system glucitol sorbitol-specific
CD200_19405	COG0629	single-stranded DNA binding
CD200_19420	COG1970	mechanosensitive ion channel activity
CD200_19425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CD200_19430	COG4786	Flagellar basal body rod
CD200_19435	COG4786	Flagellar basal body rod
CD200_19440	COG1077	Cell shape determining protein MreB Mrl
CD200_19445	COG1609	Transcriptional regulator
CD200_19455	COG1846	Transcriptional regulator
CD200_19460	COG2814	Major facilitator Superfamily
CD200_19465	COG0671	phosphoesterase, PA-phosphatase related
CD200_19470	COG1227	inorganic diphosphatase activity
CD200_19475	COG3546	catalase activity
CD200_19480	COG3361	conserved protein (COG2071)
CD200_19485	COG0517	IMP dehydrogenase activity
CD200_19490	COG0598	Magnesium transport protein CorA
CD200_19495	COG1253	flavin adenine dinucleotide binding
CD200_19500	COG0004	ammonium transporteR
CD200_19505	COG0347	Belongs to the P(II) protein family
CD200_19510	COG0740	serine-type endopeptidase activity
CD200_19520	COG0739	heme binding
CD200_19525	COG1247	-acetyltransferase
CD200_19535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CD200_19545	COG0477	Major facilitator Superfamily
CD200_19555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CD200_19560	COG3433	isochorismatase activity
CD200_19560	COG1535	isochorismatase
CD200_19565	COG1021	2,3-dihydroxybenzoate-AMP ligase
CD200_19570	COG1169	isochorismate synthase
CD200_19575	COG1028	Short-chain dehydrogenase reductase Sdr
CD200_19580	COG2819	hydrolase of the alpha beta superfamily
CD200_19585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD200_19590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CD200_19595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CD200_19600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CD200_19600	COG2207	Transcriptional regulator
CD200_19610	COG2910	NAD(P)H-binding
CD200_19615	COG1959	2 iron, 2 sulfur cluster binding
CD200_19620	COG1994	Peptidase M50
CD200_19625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CD200_19630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CD200_19640	COG3383	formate dehydrogenase (NAD+) activity
CD200_19645	COG2304	oxidoreductase activity
CD200_19650	COG2304	oxidoreductase activity
CD200_19655	COG2385	sporulation resulting in formation of a cellular spore
CD200_19660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CD200_19670	COG4836	Membrane
CD200_19675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CD200_19680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CD200_19685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CD200_19690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CD200_19695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CD200_19700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CD200_19705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CD200_19725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CD200_19730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CD200_19735	COG4475	Protein of unknown function (DUF436)
CD200_19740	COG0698	ribose 5-phosphate isomerase
CD200_19745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CD200_19750	COG1971	Probably functions as a manganese efflux pump
CD200_19755	COG0009	L-threonylcarbamoyladenylate synthase
CD200_19760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CD200_19770	COG0738	Major facilitator superfamily
CD200_19775	COG0673	inositol 2-dehydrogenase activity
CD200_19780	COG0561	phosphatase activity
CD200_19785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CD200_19790	COG1609	Transcriptional regulator
CD200_19795	COG2890	protein-(glutamine-N5) methyltransferase activity
CD200_19800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CD200_19805	COG0346	lactoylglutathione lyase activity
CD200_19810	COG0789	Transcriptional regulator
CD200_19815	COG0679	Auxin Efflux Carrier
CD200_19820	COG0281	malic enzyme
CD200_19825	COG1435	thymidine kinase activity
CD200_19830	COG0254	rRNA binding
CD200_19835	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CD200_19840	COG1494	fructose-1,6-bisphosphatase
CD200_19845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CD200_19850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CD200_19855	COG0191	fructose-bisphosphate aldolase activity
CD200_19860	COG2204	response regulator
CD200_19865	COG4821	SIS domain
CD200_19875	COG0504	CTP synthase activity
CD200_19880	COG3343	RNA polymerase activity
CD200_19885	COG1960	acyl-CoA dehydrogenase activity
CD200_19890	COG1960	acyl-CoA dehydrogenase activity
CD200_19895	COG1250	3-hydroxyacyl-CoA dehydrogenase
CD200_19900	COG0183	Belongs to the thiolase family
CD200_19905	COG0247	lactate metabolic process
CD200_19905	COG2181	nitrate reductase activity
CD200_19910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CD200_19920	COG0018	arginyl-trna synthetase
CD200_19925	COG4506	Protein conserved in bacteria
CD200_19930	COG0010	Belongs to the arginase family
CD200_19935	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CD200_19950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CD200_19960	COG1994	Peptidase M50
CD200_19965	COG1942	4-Oxalocrotonate Tautomerase
CD200_19975	COG3465	dGTPase activity
CD200_19980	COG1078	dGTPase activity
CD200_19985	COG4844	belongs to the
CD200_20010	COG2814	Major facilitator Superfamily
CD200_20035	COG1414	Transcriptional regulator
CD200_20045	COG0280	phosphate acetyltransferase
CD200_20065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CD200_20085	COG1131	(ABC) transporter
CD200_20100	COG2363	Small membrane protein
CD200_20105	COG2233	PERMEase
CD200_20115	COG1012	belongs to the aldehyde dehydrogenase family
CD200_20120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CD200_20125	COG1216	Glycosyl transferase, family 2
CD200_20130	COG0351	phosphomethylpyrimidine kinase
CD200_20140	COG1621	beta-fructofuranosidase activity
CD200_20145	COG1263	PTS System
CD200_20145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_20150	COG3711	transcriptional antiterminator
CD200_20160	COG1404	Belongs to the peptidase S8 family
CD200_20170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CD200_20175	COG0778	Nitroreductase
CD200_20185	COG0772	Belongs to the SEDS family
CD200_20190	COG0772	Belongs to the SEDS family
CD200_20215	COG0456	acetyltransferase
CD200_20250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CD200_20260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CD200_20265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CD200_20270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CD200_20290	COG3162	membrane
CD200_20295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CD200_20300	COG1070	Carbohydrate kinase
CD200_20305	COG2115	Belongs to the xylose isomerase family
CD200_20315	COG0352	thiamine-phosphate diphosphorylase activity
CD200_20320	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CD200_20325	COG0583	DNA-binding transcription factor activity
CD200_20340	COG1380	Effector of murein hydrolase LrgA
CD200_20345	COG1346	cytolysis
CD200_20355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CD200_20360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CD200_20365	COG0346	lactoylglutathione lyase activity
CD200_20370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CD200_20375	COG1442	glycosyl transferase family 8
CD200_20390	COG4585	Histidine kinase
CD200_20395	COG2197	response regulator
CD200_20400	COG2409	Drug exporters of the RND superfamily
CD200_20405	COG5522	Integral membrane protein (intg_mem_TP0381)
CD200_20410	COG2271	Major facilitator Superfamily
CD200_20415	COG4948	Mandelate Racemase Muconate Lactonizing
CD200_20420	COG0800	Aldolase
CD200_20425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CD200_20435	COG2234	aminopeptidase activity
CD200_20440	COG0477	Major facilitator Superfamily
CD200_20450	COG2357	RelA SpoT domain protein
CD200_20465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CD200_20470	COG1696	Membrane protein involved in D-alanine export
CD200_20475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CD200_20480	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CD200_20485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CD200_20490	COG2814	Major facilitator Superfamily
CD200_20495	COG1486	melibiose metabolic process
CD200_20500	COG1447	Phosphotransferase system cellobiose-specific component IIA
CD200_20505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD200_20510	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD200_20515	COG3711	transcriptional antiterminator
CD200_20515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CD200_20520	COG2094	Belongs to the DNA glycosylase MPG family
CD200_20530	COG0372	Belongs to the citrate synthase family
CD200_20535	COG2079	MmgE PrpD family protein
CD200_20540	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CD200_20555	COG1132	(ABC) transporter
CD200_20560	COG2755	lipolytic protein G-D-S-L family
CD200_20575	COG2814	Major facilitator Superfamily
CD200_20580	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CD200_20585	COG1131	(ABC) transporter
CD200_20605	COG1595	DNA-templated transcription, initiation
CD200_20610	COG2814	Major facilitator Superfamily
CD200_20615	COG0753	catalase activity
CD200_20620	COG0753	catalase activity
CD200_20625	COG0735	belongs to the Fur family
CD200_20635	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CD200_20640	COG1131	(ABC) transporter
CD200_20655	COG1131	(ABC) transporter
CD200_20705	COG3866	Pectate lyase
CD200_20710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CD200_20715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CD200_20720	COG4988	ABC transporter
CD200_20725	COG1294	oxidase, subunit
CD200_20730	COG1271	oxidase subunit
CD200_20740	COG2116	formate transmembrane transporter activity
CD200_20750	COG0281	malic enzyme
CD200_20755	COG1757	Na H antiporter
CD200_20760	COG1027	Aspartate ammonia-lyase
CD200_20765	COG0252	asparaginase activity
CD200_20770	COG1396	sequence-specific DNA binding
CD200_20775	COG2706	6-phosphogluconolactonase activity
CD200_20780	COG0745	RESPONSE REGULATOR receiver
CD200_20785	COG2205	protein histidine kinase activity
CD200_20795	COG1136	(ABC) transporter
CD200_20800	COG0577	efflux transmembrane transporter activity
CD200_20805	COG5294	Protein conserved in bacteria
CD200_20815	COG0726	polysaccharide deacetylase
CD200_20825	COG1215	transferase activity, transferring glycosyl groups
CD200_20830	COG3493	citrate carrier protein
CD200_20835	COG0584	glycerophosphoryl diester phosphodiesterase
CD200_20850	COG1368	sulfuric ester hydrolase activity
CD200_20860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CD200_20875	COG2235	arginine
CD200_20880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CD200_20890	COG0549	Belongs to the carbamate kinase family
CD200_20900	COG2723	6-phospho-beta-galactosidase activity
CD200_20905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CD200_20915	COG1595	DNA-templated transcription, initiation
CD200_20940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CD200_20945	COG2195	Cleaves the N-terminal amino acid of tripeptides
CD200_20955	COG1621	beta-fructofuranosidase activity
CD200_20960	COG2223	nitrite transmembrane transporter activity
CD200_20970	COG1609	Transcriptional regulator
CD200_20985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CD200_20995	COG0463	Glycosyl transferase, family 2
CD200_21000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CD200_21025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CD200_21040	COG2723	6-phospho-beta-galactosidase activity
CD200_21045	COG1263	PTS System
CD200_21045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_21045	COG2190	(PTS) system
CD200_21050	COG3711	transcriptional antiterminator
CD200_21055	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CD200_21060	COG1122	ATPase activity
CD200_21065	COG4721	ABC-type cobalt transport system, permease component
CD200_21070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CD200_21075	COG2224	Isocitrate lyase
CD200_21080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CD200_21090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CD200_21095	COG0577	efflux transmembrane transporter activity
CD200_21100	COG1136	(ABC) transporter
CD200_21105	COG2205	protein histidine kinase activity
CD200_21110	COG0745	RESPONSE REGULATOR receiver
CD200_21115	COG2723	6-phospho-beta-galactosidase activity
CD200_21120	COG2190	(PTS) system
CD200_21120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_21120	COG1263	PTS System
CD200_21130	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CD200_21135	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CD200_21140	COG3507	Belongs to the glycosyl hydrolase 43 family
CD200_21145	COG0513	Belongs to the DEAD box helicase family
CD200_21175	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CD200_21180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CD200_21185	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CD200_21190	COG2390	Transcriptional regulator
CD200_21200	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CD200_21205	COG3706	GGDEF domain
CD200_21210	COG5298	Protein conserved in bacteria
CD200_21215	COG1215	transferase activity, transferring glycosyl groups
CD200_21225	COG3977	Valine--pyruvate aminotransferase
CD200_21240	COG1181	Belongs to the D-alanine--D-alanine ligase family
CD200_21250	COG0191	fructose-bisphosphate aldolase activity
CD200_21255	COG1082	Xylose isomerase domain protein TIM barrel
CD200_21260	COG1082	Xylose isomerase domain protein TIM barrel
CD200_21265	COG0673	inositol 2-dehydrogenase activity
CD200_21270	COG2814	Major facilitator Superfamily
CD200_21275	COG1082	Xylose isomerase domain protein TIM barrel
CD200_21280	COG3962	Belongs to the TPP enzyme family
CD200_21285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CD200_21290	COG3718	enzyme involved in inositol metabolism
CD200_21295	COG1012	belongs to the aldehyde dehydrogenase family
CD200_21300	COG1349	DNA-binding transcription factor activity
CD200_21305	COG0667	Aldo Keto reductase
CD200_21310	COG0584	glycerophosphoryl diester phosphodiesterase
CD200_21315	COG2271	Major facilitator Superfamily
CD200_21320	COG0326	Molecular chaperone. Has ATPase activity
CD200_21325	COG0488	(ABC) transporter
CD200_21330	COG0561	phosphatase activity
CD200_21350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CD200_21380	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
CD200_21385	COG0577	efflux transmembrane transporter activity
CD200_21390	COG1136	(ABC) transporter
CD200_21395	COG2205	protein histidine kinase activity
CD200_21400	COG0745	RESPONSE REGULATOR receiver
CD200_21410	COG0840	transmembrane signaling receptor activity
CD200_21410	COG5278	phosphoserine phosphatase activity
CD200_21415	COG1115	amino acid carrier protein
CD200_21420	COG0686	Belongs to the AlaDH PNT family
CD200_21425	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CD200_21430	COG1874	Beta-galactosidase
CD200_21435	COG3833	ABC-type maltose transport systems, permease component
CD200_21440	COG1175	transmembrane transport
CD200_21445	COG2182	Extracellular solute-binding protein
CD200_21450	COG1609	Transcriptional regulator
CD200_21460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CD200_21465	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CD200_21470	COG1940	carbohydrate kinase activity
CD200_21495	COG1454	alcohol dehydrogenase
CD200_21495	COG1012	belongs to the aldehyde dehydrogenase family
CD200_21500	COG0450	alkyl hydroperoxide reductase
CD200_21505	COG3634	alkyl hydroperoxide reductase activity
CD200_21530	COG1131	(ABC) transporter
CD200_21535	COG0842	Transport permease protein
CD200_21540	COG4585	Histidine kinase
CD200_21545	COG2197	response regulator
CD200_21570	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CD200_21585	COG0456	acetyltransferase
CD200_21600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CD200_21605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CD200_21610	COG4853	Protein conserved in bacteria
CD200_21615	COG4863	YycH protein
CD200_21620	COG5002	protein histidine kinase activity
CD200_21625	COG0745	RESPONSE REGULATOR receiver
CD200_21650	COG1051	belongs to the nudix hydrolase family
CD200_21655	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CD200_21665	COG0305	Participates in initiation and elongation during chromosome replication
CD200_21680	COG3093	addiction module antidote protein HigA
CD200_21685	COG2807	transmembrane transport
CD200_21690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CD200_21695	COG0363	glucosamine-6-phosphate deaminase activity
CD200_21705	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CD200_21710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CD200_21710	COG1263	PTS System
CD200_21715	COG0359	binds to the 23S rRNA
CD200_21720	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CD200_21725	COG4241	membrane
CD200_21735	COG5577	PFAM Coat F domain
CD200_21740	COG0589	response to stress
CD200_21745	COG0659	secondary active sulfate transmembrane transporter activity
CD200_21750	COG2271	Major facilitator Superfamily
CD200_21755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CD200_21760	COG0629	single-stranded DNA binding
CD200_21765	COG0360	Binds together with S18 to 16S ribosomal RNA
CD200_21770	COG0012	GTP binding
CD200_21780	COG4481	Protein conserved in bacteria
CD200_21785	COG3949	Membrane
CD200_21795	COG1475	DNA binding
CD200_21800	COG1192	Involved in chromosome partitioning
CD200_21805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CD200_21815	COG1475	DNA binding
CD200_21820	COG0357	Ribosomal RNA small subunit methyltransferase G
CD200_21825	COG0445	tRNA wobble uridine modification
CD200_21830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CD200_21835	COG1847	R3H domain protein
CD200_21840	COG0706	membrane insertase activity
CD200_21845	COG0594	ribonuclease P activity
CD200_21850	COG0230	Belongs to the bacterial ribosomal protein bL34 family