locus-tag	class	description
I6G80_00020	COG0583	DNA-binding transcription factor activity
I6G80_00060	COG0433	COG0433 Predicted ATPase
I6G80_00070	COG5644	endopeptidase inhibitor activity
I6G80_00075	COG5644	endopeptidase inhibitor activity
I6G80_00080	COG0791	NLP P60 protein
I6G80_00080	COG0741	lytic transglycosylase activity
I6G80_00090	COG2002	toxin-antitoxin pair type II binding
I6G80_00095	COG0653	protein targeting
I6G80_00175	COG1192	Involved in chromosome partitioning
I6G80_00180	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G80_00185	COG4824	toxin secretion phage lysis holin
I6G80_00220	COG5280	Phage tail tape measure protein TP901
I6G80_00220	COG3953	SLT domain
I6G80_00320	COG0583	DNA-binding transcription factor activity
I6G80_00375	COG0433	COG0433 Predicted ATPase
I6G80_00380	COG0433	COG0433 Predicted ATPase
I6G80_00390	COG5644	endopeptidase inhibitor activity
I6G80_00395	COG0741	lytic transglycosylase activity
I6G80_00395	COG0791	NLP P60 protein
I6G80_00405	COG2002	toxin-antitoxin pair type II binding
I6G80_00410	COG0653	protein targeting
I6G80_00510	COG0433	COG0433 Predicted ATPase
I6G80_00520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G80_00525	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G80_00530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G80_00545	COG1960	acyl-CoA dehydrogenase activity
I6G80_00555	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G80_00560	COG1131	(ABC) transporter
I6G80_00565	COG1301	dicarboxylic acid transport
I6G80_00570	COG0628	permease
I6G80_00575	COG3729	General stress protein
I6G80_00580	COG0662	Cupin 2, conserved barrel domain protein
I6G80_00590	COG2217	Heavy metal translocating P-type atpase
I6G80_00595	COG4876	unkown
I6G80_00600	COG1819	glycosyl
I6G80_00605	COG1027	Aspartate ammonia-lyase
I6G80_00610	COG2261	transglycosylase associated protein
I6G80_00615	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G80_00620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G80_00630	COG3397	chitin binding
I6G80_00635	COG0028	Belongs to the TPP enzyme family
I6G80_00640	COG0531	amino acid
I6G80_00645	COG0551	DNA topoisomerase type I activity
I6G80_00645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G80_00650	COG1522	sequence-specific DNA binding
I6G80_00660	COG2814	Major facilitator Superfamily
I6G80_00675	COG3871	stress protein (general stress protein 26)
I6G80_00685	COG1917	Cupin 2, conserved barrel domain protein
I6G80_00690	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_00695	COG3711	transcriptional antiterminator
I6G80_00700	COG0246	Mannitol dehydrogenase
I6G80_00705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G80_00710	COG2213	PTS system mannitol-specific
I6G80_00715	COG2755	lipolytic protein G-D-S-L family
I6G80_00720	COG1414	Transcriptional regulator
I6G80_00725	COG1984	allophanate hydrolase subunit 2
I6G80_00730	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G80_00735	COG4336	lyase activity
I6G80_00740	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G80_00745	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6G80_00750	COG0561	phosphatase activity
I6G80_00755	COG3958	Transketolase
I6G80_00760	COG3959	Transketolase, thiamine diphosphate binding domain
I6G80_00775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G80_00785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G80_00790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G80_00795	COG0471	metal ion transport
I6G80_00800	COG1802	Transcriptional regulator
I6G80_00805	COG1587	Uroporphyrinogen-III synthase
I6G80_00805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G80_00810	COG2146	nitrite reductase [NAD(P)H] activity
I6G80_00815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G80_00820	COG0243	molybdopterin cofactor binding
I6G80_00825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G80_00830	COG1349	DNA-binding transcription factor activity
I6G80_00835	COG1276	copper resistance
I6G80_00835	COG2372	response to copper ion
I6G80_00840	COG4549	nuclear export factor GLE1
I6G80_00850	COG0697	spore germination
I6G80_00855	COG1012	belongs to the aldehyde dehydrogenase family
I6G80_00860	COG0531	amino acid
I6G80_00865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G80_00870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G80_00875	COG0640	Transcriptional regulator
I6G80_00880	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6G80_00885	COG0778	Nitroreductase
I6G80_00895	COG1309	transcriptional regulator
I6G80_00900	COG2814	Major facilitator Superfamily
I6G80_00905	COG4607	ABC-type enterochelin transport system periplasmic component
I6G80_00910	COG4604	ABC transporter, ATP-binding protein
I6G80_00915	COG4605	iron ion homeostasis
I6G80_00920	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G80_00925	COG0527	aspartate kinase activity
I6G80_00935	COG3850	Histidine kinase
I6G80_00935	COG5002	protein histidine kinase activity
I6G80_00940	COG0745	RESPONSE REGULATOR receiver
I6G80_00945	COG0577	efflux transmembrane transporter activity
I6G80_00950	COG1136	(ABC) transporter
I6G80_00955	COG0789	Transcriptional regulator
I6G80_00960	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6G80_00970	COG0697	spore germination
I6G80_00980	COG5434	Belongs to the glycosyl hydrolase 28 family
I6G80_00985	COG3104	oligopeptide transport
I6G80_00990	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
I6G80_00995	COG1874	Beta-galactosidase
I6G80_01000	COG1846	Transcriptional regulator
I6G80_01000	COG0456	acetyltransferase
I6G80_01005	COG2271	Major facilitator Superfamily
I6G80_01010	COG4214	carbohydrate transport
I6G80_01020	COG4213	ABC transporter substrate-binding protein
I6G80_01025	COG4753	response regulator
I6G80_01025	COG2207	Transcriptional regulator
I6G80_01030	COG2972	Histidine kinase
I6G80_01050	COG5444	nuclease activity
I6G80_01095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6G80_01100	COG0163	prenyltransferase activity
I6G80_01105	COG0583	DNA-binding transcription factor activity
I6G80_01110	COG0010	Belongs to the arginase family
I6G80_01115	COG0833	amino acid
I6G80_01120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G80_01125	COG3829	transcription factor binding
I6G80_01130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G80_01135	COG0765	amino acid transport
I6G80_01140	COG1126	abc transporter atp-binding protein
I6G80_01170	COG1131	(ABC) transporter
I6G80_01180	COG2364	Membrane
I6G80_01190	COG2819	hydrolase of the alpha beta superfamily
I6G80_01200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G80_01205	COG0697	spore germination
I6G80_01210	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6G80_01215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G80_01220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G80_01225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G80_01230	COG1177	transmembrane transport
I6G80_01235	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G80_01260	COG5444	nuclease activity
I6G80_01270	COG0515	serine threonine protein kinase
I6G80_01270	COG3266	domain, Protein
I6G80_01280	COG3209	COG3209 Rhs family protein
I6G80_01290	COG2723	6-phospho-beta-galactosidase activity
I6G80_01305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G80_01310	COG0765	amino acid transport
I6G80_01330	COG3458	cephalosporin-C deacetylase activity
I6G80_01335	COG0701	Predicted permease
I6G80_01340	COG3689	TIGRFAM TIGR03943 family protein
I6G80_01345	COG2508	Transcriptional regulator
I6G80_01350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G80_01355	COG1012	belongs to the aldehyde dehydrogenase family
I6G80_01360	COG0506	proline dehydrogenase activity
I6G80_01365	COG3541	Predicted nucleotidyltransferase
I6G80_01370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G80_01375	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G80_01380	COG1113	amino acid transport
I6G80_01385	COG1280	lysine exporter protein (LysE YggA)
I6G80_01390	COG1620	l-lactate permease
I6G80_01395	COG0039	L-malate dehydrogenase activity
I6G80_01400	COG2223	nitrite transmembrane transporter activity
I6G80_01405	COG0789	Transcriptional regulator
I6G80_01415	COG0785	Cytochrome C biogenesis protein
I6G80_01420	COG3853	Toxic anion resistance protein (TelA)
I6G80_01440	COG0861	Integral membrane protein TerC family
I6G80_01445	COG2310	stress, protein
I6G80_01450	COG2310	stress, protein
I6G80_01455	COG2310	stress, protein
I6G80_01475	COG1309	transcriptional regulator
I6G80_01480	COG1131	(ABC) transporter
I6G80_01490	COG0791	NLP P60 protein
I6G80_01490	COG3883	PFAM NLP P60 protein
I6G80_01495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G80_01500	COG3773	Cell wall hydrolase
I6G80_01510	COG1595	DNA-templated transcription, initiation
I6G80_01520	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_01525	COG3591	Belongs to the peptidase S1B family
I6G80_01540	COG3394	polysaccharide catabolic process
I6G80_01545	COG2188	Transcriptional regulator
I6G80_01550	COG1486	melibiose metabolic process
I6G80_01555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G80_01560	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G80_01565	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G80_01570	COG0277	FAD linked oxidase domain protein
I6G80_01575	COG0247	lactate metabolic process
I6G80_01585	COG2261	transglycosylase associated protein
I6G80_01590	COG1164	Oligoendopeptidase f
I6G80_01600	COG0456	acetyltransferase
I6G80_01610	COG1288	antiporter activity
I6G80_01625	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_01630	COG1942	4-Oxalocrotonate Tautomerase
I6G80_01635	COG0583	DNA-binding transcription factor activity
I6G80_01660	COG1131	(ABC) transporter
I6G80_01665	COG1405	negative regulation of cell septum assembly
I6G80_01665	COG3012	SEC-C Motif Domain Protein
I6G80_01670	COG1714	RDD family
I6G80_01675	COG0697	spore germination
I6G80_01700	COG0789	Transcriptional regulator
I6G80_01720	COG0318	PFAM AMP-dependent synthetase and ligase
I6G80_01725	COG1846	Transcriptional regulator
I6G80_01730	COG3173	Aminoglycoside phosphotransferase
I6G80_01755	COG1131	(ABC) transporter
I6G80_01760	COG2205	protein histidine kinase activity
I6G80_01765	COG0745	RESPONSE REGULATOR receiver
I6G80_01770	COG2721	sulfolactate sulfo-lyase activity
I6G80_01775	COG2186	Transcriptional regulator
I6G80_01780	COG4948	Mandelate Racemase Muconate Lactonizing
I6G80_01785	COG2271	Major facilitator Superfamily
I6G80_01790	COG1012	belongs to the aldehyde dehydrogenase family
I6G80_01795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G80_01800	COG0805	protein transport
I6G80_01805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G80_01810	COG3540	Alkaline phosphatase
I6G80_01835	COG0784	Response regulator, receiver
I6G80_01840	COG4191	Histidine kinase
I6G80_01850	COG2066	Belongs to the glutaminase family
I6G80_01855	COG1115	amino acid carrier protein
I6G80_01860	COG2205	protein histidine kinase activity
I6G80_01865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G80_01865	COG4451	ribulose bisphosphate carboxylase, small
I6G80_01870	COG2323	membrane
I6G80_01875	COG0789	Transcriptional regulator
I6G80_01880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_01880	COG1263	PTS System
I6G80_01880	COG2190	(PTS) system
I6G80_01890	COG2040	homocysteine
I6G80_01895	COG0833	amino acid
I6G80_01905	COG4257	antibiotic catabolic process
I6G80_01920	COG4213	ABC transporter substrate-binding protein
I6G80_01925	COG0840	transmembrane signaling receptor activity
I6G80_01930	COG0371	Dehydrogenase
I6G80_01950	COG1917	Cupin 2, conserved barrel domain protein
I6G80_01950	COG2207	Transcriptional regulator
I6G80_01955	COG0697	spore germination
I6G80_01980	COG4682	membrane
I6G80_01985	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6G80_02005	COG0477	Major facilitator Superfamily
I6G80_02010	COG1331	Highly conserved protein containing a thioredoxin domain
I6G80_02030	COG2211	Major facilitator Superfamily
I6G80_02045	COG3290	protein histidine kinase activity
I6G80_02050	COG4565	transcriptional regulatory protein
I6G80_02055	COG3181	Tripartite tricarboxylate transporter family receptor
I6G80_02060	COG2851	Citrate transporter
I6G80_02065	COG1113	amino acid transport
I6G80_02070	COG1011	Hydrolase
I6G80_02095	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G80_02100	COG1132	(ABC) transporter
I6G80_02110	COG2814	Major facilitator Superfamily
I6G80_02115	COG0640	Transcriptional regulator
I6G80_02120	COG1725	Transcriptional regulator
I6G80_02125	COG1131	(ABC) transporter
I6G80_02140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G80_02145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G80_02150	COG4856	YbbR-like protein
I6G80_02155	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6G80_02160	COG5662	AntiSigma factor
I6G80_02165	COG1595	DNA-templated transcription, initiation
I6G80_02200	COG1683	Conserved Protein
I6G80_02205	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6G80_02210	COG1737	Transcriptional regulator
I6G80_02215	COG1263	PTS System
I6G80_02215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_02220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G80_02225	COG1472	Belongs to the glycosyl hydrolase 3 family
I6G80_02230	COG3876	Protein conserved in bacteria
I6G80_02245	COG0385	Bile acid
I6G80_02255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G80_02290	COG0726	polysaccharide deacetylase
I6G80_02295	COG2194	sulfuric ester hydrolase activity
I6G80_02305	COG0489	protein tyrosine kinase activity
I6G80_02310	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G80_02325	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G80_02330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G80_02335	COG0101	tRNA pseudouridine synthase activity
I6G80_02340	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6G80_02345	COG1122	ATPase activity
I6G80_02350	COG1122	ATPase activity
I6G80_02355	COG0203	ribosomal protein L17
I6G80_02360	COG0202	RNA polymerase activity
I6G80_02365	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G80_02370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G80_02375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G80_02380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G80_02385	COG2163	COG2163 Ribosomal protein L14E L6E L27E
I6G80_02390	COG0024	Methionine aminopeptidase
I6G80_02395	COG0563	adenylate kinase activity
I6G80_02400	COG0201	protein transport
I6G80_02405	COG0200	Binds to the 23S rRNA
I6G80_02410	COG1841	ribosomal large subunit assembly
I6G80_02415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G80_02420	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6G80_02425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G80_02430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G80_02435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G80_02440	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G80_02445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G80_02450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G80_02455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G80_02460	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G80_02465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G80_02470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6G80_02475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G80_02480	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G80_02485	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G80_02490	COG0089	rRNA binding
I6G80_02495	COG0088	Forms part of the polypeptide exit tunnel
I6G80_02500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G80_02510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G80_02515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G80_02520	COG0049	tRNA binding
I6G80_02525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G80_02530	COG1358	cellular component organization or biogenesis
I6G80_02535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G80_02540	COG0085	RNA polymerase activity
I6G80_02545	COG2813	Specifically methylates the guanine in position
I6G80_02550	COG0222	ribosome binding
I6G80_02555	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G80_02560	COG0081	regulation of translation
I6G80_02565	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G80_02570	COG0250	Participates in transcription elongation, termination and antitermination
I6G80_02580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G80_02590	COG3688	RNA-binding protein containing a PIN domain
I6G80_02595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G80_02600	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6G80_02605	COG0215	cysteine-tRNA ligase activity
I6G80_02610	COG1045	serine acetyltransferase
I6G80_02615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G80_02620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6G80_02625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6G80_02630	COG4956	integral membrane protein (PIN domain superfamily)
I6G80_02635	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I6G80_02640	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6G80_02645	COG0542	response to heat
I6G80_02650	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I6G80_02655	COG3880	PFAM UvrB UvrC protein
I6G80_02660	COG4463	regulation of RNA biosynthetic process
I6G80_02740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G80_02745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G80_02750	COG1396	sequence-specific DNA binding
I6G80_02755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G80_02760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G80_02765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G80_02770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G80_02775	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G80_02780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G80_02785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G80_02790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G80_02795	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G80_02800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6G80_02805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G80_02810	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G80_02815	COG0037	tRNA processing
I6G80_02820	COG0515	serine threonine protein kinase
I6G80_02825	COG2304	oxidoreductase activity
I6G80_02830	COG2208	phosphoserine phosphatase activity
I6G80_02845	COG1098	S1 RNA binding domain
I6G80_02850	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6G80_02865	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G80_02870	COG3956	TIGRFAM MazG family protein
I6G80_02875	COG2244	polysaccharide biosynthetic process
I6G80_02880	COG2002	toxin-antitoxin pair type II binding
I6G80_02885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G80_02895	COG0193	aminoacyl-tRNA hydrolase activity
I6G80_02900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G80_02905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G80_02910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G80_02915	COG2088	sporulation resulting in formation of a cellular spore
I6G80_02920	COG0251	oxidation-reduction process
I6G80_02925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G80_02930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G80_02940	COG4466	Protein conserved in bacteria
I6G80_02950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G80_02955	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6G80_02960	COG3583	domain protein
I6G80_02960	COG3584	3D domain protein
I6G80_02965	COG0084	hydrolase, TatD family'
I6G80_02970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G80_02970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G80_02975	COG2002	toxin-antitoxin pair type II binding
I6G80_02980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G80_02985	COG2827	Endonuclease containing a URI domain
I6G80_02990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G80_02995	COG4467	Involved in initiation control of chromosome replication
I6G80_03000	COG1774	PSP1 C-terminal conserved region
I6G80_03005	COG0470	DNA polymerase III
I6G80_03010	COG1728	Protein conserved in bacteria
I6G80_03015	COG3870	Protein conserved in bacteria
I6G80_03020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G80_03025	COG1982	Orn Lys Arg decarboxylase major
I6G80_03030	COG3853	Toxic anion resistance protein (TelA)
I6G80_03035	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I6G80_03080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G80_03085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6G80_03090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G80_03100	COG0590	tRNA wobble adenosine to inosine editing
I6G80_03105	COG1335	isochorismatase
I6G80_03110	COG1388	LysM domain
I6G80_03110	COG3858	chitin binding
I6G80_03115	COG1428	Deoxynucleoside kinase
I6G80_03120	COG1428	Deoxynucleoside kinase
I6G80_03135	COG3835	regulator
I6G80_03140	COG2610	gluconate transmembrane transporter activity
I6G80_03145	COG1929	Belongs to the glycerate kinase type-1 family
I6G80_03150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G80_03155	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6G80_03160	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6G80_03165	COG1686	Belongs to the peptidase S11 family
I6G80_03170	COG0517	IMP dehydrogenase activity
I6G80_03170	COG0516	GMP reductase activity
I6G80_03205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G80_03210	COG0187	DNA topoisomerase II activity
I6G80_03220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G80_03225	COG2501	S4 domain
I6G80_03230	COG0592	DNA-directed DNA polymerase activity
I6G80_03235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G80_03245	COG0594	ribonuclease P activity
I6G80_03250	COG0706	membrane insertase activity
I6G80_03255	COG1847	R3H domain protein
I6G80_03260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G80_03265	COG0445	tRNA wobble uridine modification
I6G80_03270	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G80_03275	COG1475	DNA binding
I6G80_03285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G80_03290	COG1192	Involved in chromosome partitioning
I6G80_03295	COG1475	DNA binding
I6G80_03305	COG3949	Membrane
I6G80_03310	COG4481	Protein conserved in bacteria
I6G80_03315	COG0012	GTP binding
I6G80_03320	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G80_03325	COG0629	single-stranded DNA binding
I6G80_03330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G80_03335	COG2271	Major facilitator Superfamily
I6G80_03340	COG0659	secondary active sulfate transmembrane transporter activity
I6G80_03345	COG0589	response to stress
I6G80_03350	COG5577	PFAM Coat F domain
I6G80_03360	COG4241	membrane
I6G80_03365	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6G80_03370	COG0359	binds to the 23S rRNA
I6G80_03375	COG1263	PTS System
I6G80_03375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_03380	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6G80_03385	COG2188	Transcriptional regulator
I6G80_03390	COG0363	glucosamine-6-phosphate deaminase activity
I6G80_03395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G80_03400	COG2807	transmembrane transport
I6G80_03405	COG3093	addiction module antidote protein HigA
I6G80_03420	COG0305	Participates in initiation and elongation during chromosome replication
I6G80_03430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G80_03435	COG1051	belongs to the nudix hydrolase family
I6G80_03460	COG0745	RESPONSE REGULATOR receiver
I6G80_03465	COG5002	protein histidine kinase activity
I6G80_03470	COG4863	YycH protein
I6G80_03475	COG4853	Protein conserved in bacteria
I6G80_03480	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G80_03485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G80_03500	COG0456	acetyltransferase
I6G80_03515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G80_03545	COG2197	response regulator
I6G80_03610	COG2197	response regulator
I6G80_03635	COG0456	acetyltransferase
I6G80_03650	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G80_03705	COG0456	acetyltransferase
I6G80_03720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G80_03750	COG2197	response regulator
I6G80_03760	COG0842	Transport permease protein
I6G80_03765	COG1131	(ABC) transporter
I6G80_03790	COG3634	alkyl hydroperoxide reductase activity
I6G80_03795	COG0450	alkyl hydroperoxide reductase
I6G80_03800	COG1454	alcohol dehydrogenase
I6G80_03800	COG1012	belongs to the aldehyde dehydrogenase family
I6G80_03825	COG1940	carbohydrate kinase activity
I6G80_03830	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6G80_03835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G80_03845	COG1609	Transcriptional regulator
I6G80_03850	COG2182	Extracellular solute-binding protein
I6G80_03855	COG1175	transmembrane transport
I6G80_03860	COG3833	ABC-type maltose transport systems, permease component
I6G80_03865	COG1874	Beta-galactosidase
I6G80_03870	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6G80_03875	COG0686	Belongs to the AlaDH PNT family
I6G80_03880	COG1115	amino acid carrier protein
I6G80_03885	COG5278	phosphoserine phosphatase activity
I6G80_03885	COG0840	transmembrane signaling receptor activity
I6G80_03895	COG0745	RESPONSE REGULATOR receiver
I6G80_03900	COG2205	protein histidine kinase activity
I6G80_03905	COG1136	(ABC) transporter
I6G80_03910	COG0577	efflux transmembrane transporter activity
I6G80_03915	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I6G80_03945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G80_03965	COG0561	phosphatase activity
I6G80_03970	COG0488	(ABC) transporter
I6G80_03975	COG0326	Molecular chaperone. Has ATPase activity
I6G80_03980	COG2271	Major facilitator Superfamily
I6G80_03985	COG0584	glycerophosphoryl diester phosphodiesterase
I6G80_03990	COG0667	Aldo Keto reductase
I6G80_03995	COG1349	DNA-binding transcription factor activity
I6G80_04000	COG1012	belongs to the aldehyde dehydrogenase family
I6G80_04005	COG3718	enzyme involved in inositol metabolism
I6G80_04010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G80_04015	COG3962	Belongs to the TPP enzyme family
I6G80_04020	COG1082	Xylose isomerase domain protein TIM barrel
I6G80_04030	COG0673	inositol 2-dehydrogenase activity
I6G80_04035	COG1082	Xylose isomerase domain protein TIM barrel
I6G80_04040	COG1082	Xylose isomerase domain protein TIM barrel
I6G80_04045	COG0191	fructose-bisphosphate aldolase activity
I6G80_04055	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G80_04070	COG3977	Valine--pyruvate aminotransferase
I6G80_04085	COG5298	Protein conserved in bacteria
I6G80_04090	COG3706	GGDEF domain
I6G80_04095	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6G80_04105	COG2390	Transcriptional regulator
I6G80_04110	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G80_04115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G80_04120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6G80_04150	COG0513	Belongs to the DEAD box helicase family
I6G80_04155	COG3507	Belongs to the glycosyl hydrolase 43 family
I6G80_04160	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G80_04165	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6G80_04175	COG2190	(PTS) system
I6G80_04175	COG1263	PTS System
I6G80_04175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_04180	COG2723	6-phospho-beta-galactosidase activity
I6G80_04185	COG0745	RESPONSE REGULATOR receiver
I6G80_04190	COG2205	protein histidine kinase activity
I6G80_04195	COG1136	(ABC) transporter
I6G80_04200	COG0577	efflux transmembrane transporter activity
I6G80_04205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6G80_04215	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G80_04220	COG2224	Isocitrate lyase
I6G80_04230	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G80_04235	COG4721	ABC-type cobalt transport system, permease component
I6G80_04240	COG1122	ATPase activity
I6G80_04245	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6G80_04250	COG3711	transcriptional antiterminator
I6G80_04255	COG1263	PTS System
I6G80_04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_04255	COG2190	(PTS) system
I6G80_04260	COG2723	6-phospho-beta-galactosidase activity
I6G80_04275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G80_04300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G80_04305	COG0463	Glycosyl transferase, family 2
I6G80_04310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6G80_04315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G80_04330	COG1609	Transcriptional regulator
I6G80_04335	COG2223	nitrite transmembrane transporter activity
I6G80_04340	COG1621	beta-fructofuranosidase activity
I6G80_04345	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G80_04350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G80_04375	COG1595	DNA-templated transcription, initiation
I6G80_04385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G80_04400	COG0549	Belongs to the carbamate kinase family
I6G80_04410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G80_04415	COG2235	arginine
I6G80_04425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G80_04435	COG1368	sulfuric ester hydrolase activity
I6G80_04450	COG0584	glycerophosphoryl diester phosphodiesterase
I6G80_04455	COG3493	citrate carrier protein
I6G80_04470	COG0726	polysaccharide deacetylase
I6G80_04485	COG5294	Protein conserved in bacteria
I6G80_04490	COG0577	efflux transmembrane transporter activity
I6G80_04495	COG1136	(ABC) transporter
I6G80_04500	COG2205	protein histidine kinase activity
I6G80_04505	COG0745	RESPONSE REGULATOR receiver
I6G80_04510	COG2706	6-phosphogluconolactonase activity
I6G80_04515	COG1396	sequence-specific DNA binding
I6G80_04520	COG0252	asparaginase activity
I6G80_04525	COG1027	Aspartate ammonia-lyase
I6G80_04530	COG1757	Na H antiporter
I6G80_04535	COG0281	malic enzyme
I6G80_04545	COG2116	formate transmembrane transporter activity
I6G80_04550	COG1271	oxidase subunit
I6G80_04555	COG1294	oxidase, subunit
I6G80_04560	COG4988	ABC transporter
I6G80_04565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6G80_04570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G80_04625	COG1131	(ABC) transporter
I6G80_04640	COG1131	(ABC) transporter
I6G80_04645	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G80_04650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G80_04655	COG0735	belongs to the Fur family
I6G80_04660	COG0753	catalase activity
I6G80_04665	COG0753	catalase activity
I6G80_04670	COG2814	Major facilitator Superfamily
I6G80_04675	COG1595	DNA-templated transcription, initiation
I6G80_04695	COG1131	(ABC) transporter
I6G80_04700	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G80_04705	COG2814	Major facilitator Superfamily
I6G80_04720	COG2755	lipolytic protein G-D-S-L family
I6G80_04725	COG1132	(ABC) transporter
I6G80_04740	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6G80_04745	COG2079	MmgE PrpD family protein
I6G80_04750	COG0372	Belongs to the citrate synthase family
I6G80_04760	COG2094	Belongs to the DNA glycosylase MPG family
I6G80_04765	COG3711	transcriptional antiterminator
I6G80_04765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G80_04770	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G80_04775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G80_04780	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G80_04785	COG1486	melibiose metabolic process
I6G80_04790	COG2814	Major facilitator Superfamily
I6G80_04795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G80_04800	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6G80_04805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G80_04810	COG1696	Membrane protein involved in D-alanine export
I6G80_04815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G80_04830	COG2357	RelA SpoT domain protein
I6G80_04840	COG0477	Major facilitator Superfamily
I6G80_04845	COG2234	aminopeptidase activity
I6G80_04855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G80_04860	COG0800	Aldolase
I6G80_04865	COG4948	Mandelate Racemase Muconate Lactonizing
I6G80_04870	COG2271	Major facilitator Superfamily
I6G80_04875	COG5522	Integral membrane protein (intg_mem_TP0381)
I6G80_04880	COG2409	Drug exporters of the RND superfamily
I6G80_04885	COG2197	response regulator
I6G80_04890	COG4585	Histidine kinase
I6G80_04900	COG1442	glycosyl transferase family 8
I6G80_04905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G80_04910	COG0346	lactoylglutathione lyase activity
I6G80_04915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G80_04920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G80_04930	COG1346	cytolysis
I6G80_04935	COG1380	Effector of murein hydrolase LrgA
I6G80_04950	COG0583	DNA-binding transcription factor activity
I6G80_04955	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6G80_04960	COG0352	thiamine-phosphate diphosphorylase activity
I6G80_04970	COG2115	Belongs to the xylose isomerase family
I6G80_04975	COG1070	Carbohydrate kinase
I6G80_04980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G80_04985	COG3162	membrane
I6G80_05000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G80_05005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G80_05010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G80_05020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G80_05055	COG0456	acetyltransferase
I6G80_05070	COG3314	Sporulation integral membrane protein YlbJ
I6G80_05075	COG0772	Belongs to the SEDS family
I6G80_05080	COG0772	Belongs to the SEDS family
I6G80_05085	COG1473	amidohydrolase
I6G80_05090	COG0778	Nitroreductase
I6G80_05095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G80_05105	COG1404	Belongs to the peptidase S8 family
I6G80_05115	COG3711	transcriptional antiterminator
I6G80_05120	COG1263	PTS System
I6G80_05120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_05125	COG1621	beta-fructofuranosidase activity
I6G80_05135	COG0351	phosphomethylpyrimidine kinase
I6G80_05140	COG1216	Glycosyl transferase, family 2
I6G80_05145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G80_05150	COG1012	belongs to the aldehyde dehydrogenase family
I6G80_05160	COG2233	PERMEase
I6G80_05165	COG2363	Small membrane protein
I6G80_05180	COG1131	(ABC) transporter
I6G80_05200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G80_05210	COG3253	May function as heme-dependent peroxidase
I6G80_05215	COG0280	phosphate acetyltransferase
I6G80_05225	COG1414	Transcriptional regulator
I6G80_05250	COG2814	Major facilitator Superfamily
I6G80_05275	COG4844	belongs to the
I6G80_05280	COG1078	dGTPase activity
I6G80_05285	COG3465	dGTPase activity
I6G80_05295	COG1942	4-Oxalocrotonate Tautomerase
I6G80_05300	COG1994	Peptidase M50
I6G80_05310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G80_05325	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6G80_05330	COG0010	Belongs to the arginase family
I6G80_05335	COG4506	Protein conserved in bacteria
I6G80_05340	COG0018	arginyl-trna synthetase
I6G80_05350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G80_05355	COG0247	lactate metabolic process
I6G80_05355	COG2181	nitrate reductase activity
I6G80_05360	COG0183	Belongs to the thiolase family
I6G80_05365	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G80_05370	COG1960	acyl-CoA dehydrogenase activity
I6G80_05375	COG1960	acyl-CoA dehydrogenase activity
I6G80_05385	COG3343	RNA polymerase activity
I6G80_05390	COG0504	CTP synthase activity
I6G80_05400	COG4821	SIS domain
I6G80_05405	COG2204	response regulator
I6G80_05410	COG0191	fructose-bisphosphate aldolase activity
I6G80_05415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G80_05420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G80_05425	COG1494	fructose-1,6-bisphosphatase
I6G80_05430	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G80_05435	COG0254	rRNA binding
I6G80_05440	COG1435	thymidine kinase activity
I6G80_05445	COG0281	malic enzyme
I6G80_05450	COG0679	Auxin Efflux Carrier
I6G80_05455	COG0789	Transcriptional regulator
I6G80_05460	COG0346	lactoylglutathione lyase activity
I6G80_05465	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G80_05470	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G80_05475	COG1609	Transcriptional regulator
I6G80_05480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G80_05485	COG0561	phosphatase activity
I6G80_05490	COG0673	inositol 2-dehydrogenase activity
I6G80_05495	COG0738	Major facilitator superfamily
I6G80_05505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G80_05510	COG0009	L-threonylcarbamoyladenylate synthase
I6G80_05515	COG1971	Probably functions as a manganese efflux pump
I6G80_05520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G80_05525	COG0698	ribose 5-phosphate isomerase
I6G80_05530	COG4475	Protein of unknown function (DUF436)
I6G80_05535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6G80_05540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G80_05555	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G80_05560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G80_05565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G80_05570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6G80_05575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G80_05580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G80_05585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6G80_05590	COG4836	Membrane
I6G80_05600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G80_05605	COG2385	sporulation resulting in formation of a cellular spore
I6G80_05610	COG2304	oxidoreductase activity
I6G80_05615	COG2304	oxidoreductase activity
I6G80_05620	COG3383	formate dehydrogenase (NAD+) activity
I6G80_05625	COG2223	nitrite transmembrane transporter activity
I6G80_05630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G80_05635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G80_05640	COG1994	Peptidase M50
I6G80_05650	COG1959	2 iron, 2 sulfur cluster binding
I6G80_05655	COG2910	NAD(P)H-binding
I6G80_05665	COG2207	Transcriptional regulator
I6G80_05665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G80_05670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G80_05675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G80_05680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G80_05685	COG2819	hydrolase of the alpha beta superfamily
I6G80_05690	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_05695	COG1169	isochorismate synthase
I6G80_05700	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6G80_05705	COG1535	isochorismatase
I6G80_05705	COG3433	isochorismatase activity
I6G80_05710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G80_05715	COG3251	PFAM MbtH domain protein
I6G80_05720	COG0477	Major facilitator Superfamily
I6G80_05730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G80_05740	COG1247	-acetyltransferase
I6G80_05745	COG0739	heme binding
I6G80_05755	COG0740	serine-type endopeptidase activity
I6G80_05760	COG0347	Belongs to the P(II) protein family
I6G80_05765	COG0004	ammonium transporteR
I6G80_05770	COG1253	flavin adenine dinucleotide binding
I6G80_05775	COG0598	Magnesium transport protein CorA
I6G80_05780	COG0517	IMP dehydrogenase activity
I6G80_05785	COG3361	conserved protein (COG2071)
I6G80_05790	COG3546	catalase activity
I6G80_05795	COG1227	inorganic diphosphatase activity
I6G80_05800	COG0671	phosphoesterase, PA-phosphatase related
I6G80_05805	COG2814	Major facilitator Superfamily
I6G80_05810	COG1846	Transcriptional regulator
I6G80_05815	COG1609	Transcriptional regulator
I6G80_05820	COG1077	Cell shape determining protein MreB Mrl
I6G80_05825	COG4786	Flagellar basal body rod
I6G80_05830	COG4786	Flagellar basal body rod
I6G80_05835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G80_05840	COG1970	mechanosensitive ion channel activity
I6G80_05855	COG0629	single-stranded DNA binding
I6G80_05875	COG3732	PTS system glucitol sorbitol-specific
I6G80_05885	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_05895	COG1349	DNA-binding transcription factor activity
I6G80_05900	COG0561	phosphatase activity
I6G80_05910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G80_05915	COG4715	Zinc finger, swim domain protein
I6G80_05925	COG3944	biosynthesis protein
I6G80_05930	COG4464	protein tyrosine phosphatase activity
I6G80_05935	COG2059	Chromate
I6G80_05940	COG2059	Chromate
I6G80_05945	COG1522	sequence-specific DNA binding
I6G80_05950	COG0405	Gamma-glutamyltransferase
I6G80_05960	COG0583	DNA-binding transcription factor activity
I6G80_05965	COG0028	Belongs to the TPP enzyme family
I6G80_05970	COG3527	Alpha-acetolactate decarboxylase
I6G80_05980	COG1879	ABC-type sugar transport system periplasmic component
I6G80_05985	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G80_05990	COG1129	ABC transporter
I6G80_05995	COG1869	D-ribose catabolic process
I6G80_06000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G80_06005	COG1609	Transcriptional regulator
I6G80_06010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G80_06020	COG2843	Capsule synthesis protein
I6G80_06030	COG0791	NLP P60 protein
I6G80_06035	COG0561	phosphatase activity
I6G80_06040	COG1316	TRANSCRIPTIONal
I6G80_06050	COG1063	alcohol dehydrogenase
I6G80_06055	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_06060	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I6G80_06065	COG1609	Transcriptional regulator
I6G80_06070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G80_06075	COG0800	Aldolase
I6G80_06095	COG1482	cell wall glycoprotein biosynthetic process
I6G80_06100	COG4193	domain, Protein
I6G80_06105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G80_06110	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6G80_06115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G80_06120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G80_06125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G80_06125	COG0463	Glycosyl transferase, family 2
I6G80_06130	COG1682	transport, permease protein
I6G80_06135	COG1134	teichoic acid transport
I6G80_06140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G80_06150	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G80_06155	COG1316	TRANSCRIPTIONal
I6G80_06165	COG2247	cell wall binding repeat
I6G80_06165	COG2385	sporulation resulting in formation of a cellular spore
I6G80_06170	COG2247	cell wall binding repeat
I6G80_06170	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G80_06180	COG2244	polysaccharide biosynthetic process
I6G80_06185	COG0438	transferase activity, transferring glycosyl groups
I6G80_06185	COG0297	glycogen (starch) synthase activity
I6G80_06190	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6G80_06195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G80_06200	COG3307	-O-antigen
I6G80_06205	COG3206	protein involved in exopolysaccharide biosynthesis
I6G80_06210	COG1215	transferase activity, transferring glycosyl groups
I6G80_06215	COG0438	transferase activity, transferring glycosyl groups
I6G80_06220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G80_06230	COG1316	TRANSCRIPTIONal
I6G80_06235	COG1739	Uncharacterized protein family UPF0029
I6G80_06240	COG4585	Histidine kinase
I6G80_06245	COG2197	response regulator
I6G80_06250	COG1307	EDD domain protein, DegV family
I6G80_06255	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6G80_06265	COG1040	competence protein
I6G80_06275	COG2747	anti-sigma28 factor FlgM
I6G80_06280	COG3418	PFAM FlgN family protein
I6G80_06285	COG4786	Flagellar basal body rod
I6G80_06285	COG1256	bacterial-type flagellum assembly
I6G80_06290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G80_06300	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
I6G80_06305	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6G80_06310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G80_06315	COG1334	flagellar protein FlaG
I6G80_06320	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6G80_06325	COG1516	flagellar protein fliS
I6G80_06340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G80_06345	COG0653	protein targeting
I6G80_06355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G80_06360	COG2010	Cytochrome c
I6G80_06365	COG2884	Cell division ATP-binding protein ftsE
I6G80_06370	COG2177	Part of the ABC transporter FtsEX involved in
I6G80_06375	COG0791	NLP P60 protein
I6G80_06375	COG3883	PFAM NLP P60 protein
I6G80_06380	COG0473	3-isopropylmalate dehydrogenase activity
I6G80_06385	COG3409	Peptidoglycan-binding domain 1 protein
I6G80_06385	COG0793	Belongs to the peptidase S41A family
I6G80_06395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G80_06405	COG4897	Protein conserved in bacteria
I6G80_06410	COG0556	nucleotide-excision repair
I6G80_06415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G80_06440	COG3595	metallopeptidase activity
I6G80_06445	COG1983	PspC domain protein
I6G80_06450	COG1950	PFAM Membrane protein of
I6G80_06455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G80_06460	COG2814	Major facilitator Superfamily
I6G80_06465	COG1846	Transcriptional regulator
I6G80_06470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6G80_06475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G80_06480	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6G80_06485	COG0546	phosphoglycolate phosphatase activity
I6G80_06490	COG0110	maltose O-acetyltransferase activity
I6G80_06495	COG5297	Belongs to the glycosyl hydrolase family 6
I6G80_06500	COG4990	cell redox homeostasis
I6G80_06505	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6G80_06510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G80_06515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G80_06520	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G80_06525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G80_06530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6G80_06535	COG0107	imidazoleglycerol-phosphate synthase activity
I6G80_06540	COG0140	phosphoribosyl-ATP diphosphatase activity
I6G80_06540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G80_06545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G80_06550	COG0457	Tetratricopeptide repeat
I6G80_06555	COG0492	ferredoxin-NADP+ reductase activity
I6G80_06560	COG1051	belongs to the nudix hydrolase family
I6G80_06565	COG1660	Displays ATPase and GTPase activities
I6G80_06570	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6G80_06575	COG1481	regulation of sporulation
I6G80_06580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G80_06585	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6G80_06590	COG2732	(Barnase) inhibitor
I6G80_06600	COG0640	Transcriptional regulator
I6G80_06605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G80_06610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G80_06615	COG0288	reversible hydration of carbon dioxide
I6G80_06620	COG0659	secondary active sulfate transmembrane transporter activity
I6G80_06625	COG1078	dGTPase activity
I6G80_06630	COG1694	Mazg nucleotide pyrophosphohydrolase
I6G80_06635	COG1611	Belongs to the LOG family
I6G80_06640	COG0740	serine-type endopeptidase activity
I6G80_06655	COG1621	beta-fructofuranosidase activity
I6G80_06660	COG1621	beta-fructofuranosidase activity
I6G80_06665	COG1902	pentaerythritol trinitrate reductase activity
I6G80_06670	COG1733	regulation of RNA biosynthetic process
I6G80_06680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G80_06695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G80_06705	COG2271	Major facilitator Superfamily
I6G80_06710	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G80_06715	COG1396	sequence-specific DNA binding
I6G80_06720	COG3944	biosynthesis protein
I6G80_06725	COG0489	protein tyrosine kinase activity
I6G80_06730	COG1086	Polysaccharide biosynthesis protein
I6G80_06735	COG0438	transferase activity, transferring glycosyl groups
I6G80_06740	COG1215	transferase activity, transferring glycosyl groups
I6G80_06745	COG0438	transferase activity, transferring glycosyl groups
I6G80_06755	COG1216	Glycosyl transferase, family 2
I6G80_06760	COG5039	Polysaccharide pyruvyl transferase
I6G80_06765	COG1216	Glycosyl transferase, family 2
I6G80_06770	COG2244	polysaccharide biosynthetic process
I6G80_06775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G80_06780	COG0110	maltose O-acetyltransferase activity
I6G80_06785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G80_06790	COG5039	Polysaccharide pyruvyl transferase
I6G80_06800	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G80_06805	COG1620	l-lactate permease
I6G80_06810	COG2186	Transcriptional regulator
I6G80_06815	COG0247	lactate metabolic process
I6G80_06820	COG1139	Iron-sulfur cluster binding protein
I6G80_06825	COG1556	Lactate utilization protein
I6G80_06845	COG1113	amino acid transport
I6G80_06850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G80_06855	COG2390	Transcriptional regulator
I6G80_06860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G80_06865	COG0126	phosphoglycerate kinase activity
I6G80_06870	COG0149	triose-phosphate isomerase activity
I6G80_06875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6G80_06880	COG0148	phosphopyruvate hydratase activity
I6G80_06885	COG0693	protein deglycase activity
I6G80_06895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G80_06900	COG4640	response to antibiotic
I6G80_06910	COG2095	MarC family integral membrane protein
I6G80_06915	COG1510	regulation of RNA biosynthetic process
I6G80_06920	COG1125	glycine betaine transport
I6G80_06920	COG0517	IMP dehydrogenase activity
I6G80_06925	COG1174	glycine betaine transport
I6G80_06930	COG1732	Glycine betaine
I6G80_06935	COG1174	glycine betaine transport
I6G80_06940	COG1396	sequence-specific DNA binding
I6G80_06945	COG1396	sequence-specific DNA binding
I6G80_06950	COG1476	TRANSCRIPTIONal
I6G80_06955	COG2002	toxin-antitoxin pair type II binding
I6G80_06960	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G80_06965	COG1647	Serine aminopeptidase, S33
I6G80_06970	COG0557	exoribonuclease II activity
I6G80_06975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G80_07135	COG1802	Transcriptional regulator
I6G80_07135	COG4626	Terminase
I6G80_07195	COG3953	SLT domain
I6G80_07195	COG5280	Phage tail tape measure protein TP901
I6G80_07205	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G80_07250	COG5444	nuclease activity
I6G80_07310	COG2140	Oxalate decarboxylase
I6G80_07320	COG1191	sigma factor activity
I6G80_07330	COG1054	Belongs to the UPF0176 family
I6G80_07335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6G80_07340	COG0673	inositol 2-dehydrogenase activity
I6G80_07350	COG1846	Transcriptional regulator
I6G80_07360	COG2124	cytochrome p450
I6G80_07370	COG2814	Major facilitator Superfamily
I6G80_07375	COG2814	Major facilitator Superfamily
I6G80_07380	COG3347	Dehydrogenase
I6G80_07380	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_07390	COG4952	isomerase
I6G80_07395	COG1070	Carbohydrate kinase
I6G80_07400	COG1349	DNA-binding transcription factor activity
I6G80_07405	COG0693	protein deglycase activity
I6G80_07410	COG1937	Protein conserved in bacteria
I6G80_07415	COG2608	mercury ion transmembrane transporter activity
I6G80_07420	COG2217	Heavy metal translocating P-type atpase
I6G80_07440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G80_07440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G80_07440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G80_07445	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G80_07445	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G80_07460	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G80_07465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G80_07470	COG1121	(ABC) transporter
I6G80_07475	COG1472	Belongs to the glycosyl hydrolase 3 family
I6G80_07480	COG1501	Belongs to the glycosyl hydrolase 31 family
I6G80_07485	COG0395	ABC-type sugar transport system, permease component
I6G80_07490	COG1175	transmembrane transport
I6G80_07500	COG2217	Heavy metal translocating P-type atpase
I6G80_07505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G80_07510	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G80_07515	COG0456	acetyltransferase
I6G80_07520	COG0456	acetyltransferase
I6G80_07520	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G80_07525	COG2860	membrane
I6G80_07530	COG3973	AAA domain
I6G80_07540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G80_07545	COG1940	carbohydrate kinase activity
I6G80_07550	COG0656	L-ascorbic acid biosynthetic process
I6G80_07555	COG2814	Major facilitator Superfamily
I6G80_07560	COG1368	sulfuric ester hydrolase activity
I6G80_07565	COG1988	membrane-bound metal-dependent
I6G80_07575	COG0531	amino acid
I6G80_07580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G80_07585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G80_07590	COG1120	ATPase activity
I6G80_07595	COG0745	RESPONSE REGULATOR receiver
I6G80_07600	COG2205	protein histidine kinase activity
I6G80_07605	COG1904	glucuronate isomerase
I6G80_07610	COG2211	Major facilitator Superfamily
I6G80_07615	COG1609	Transcriptional regulator
I6G80_07620	COG0246	Mannitol dehydrogenase
I6G80_07625	COG2721	sulfolactate sulfo-lyase activity
I6G80_07635	COG0583	DNA-binding transcription factor activity
I6G80_07640	COG2258	MOSC domain
I6G80_07645	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_07650	COG1802	Transcriptional regulator
I6G80_07655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G80_07660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G80_07665	COG1120	ATPase activity
I6G80_07670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G80_07690	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_07695	COG2096	Adenosyltransferase
I6G80_07700	COG4677	pectinesterase activity
I6G80_07705	COG4758	membrane
I6G80_07710	COG1842	Phage shock protein A
I6G80_07720	COG4758	membrane
I6G80_07725	COG4585	Histidine kinase
I6G80_07730	COG2197	response regulator
I6G80_07745	COG0814	amino acid
I6G80_07750	COG0697	spore germination
I6G80_07760	COG0114	fumarate hydratase activity
I6G80_07765	COG1309	transcriptional regulator
I6G80_07775	COG2770	Histidine kinase
I6G80_07775	COG2205	protein histidine kinase activity
I6G80_07780	COG0745	RESPONSE REGULATOR receiver
I6G80_07785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G80_07790	COG0783	Belongs to the Dps family
I6G80_07795	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_07800	COG1686	Belongs to the peptidase S11 family
I6G80_07815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G80_07820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G80_07825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G80_07830	COG1120	ATPase activity
I6G80_07845	COG5577	PFAM Coat F domain
I6G80_07860	COG1024	Enoyl-CoA hydratase
I6G80_07860	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G80_07865	COG0183	Belongs to the thiolase family
I6G80_07870	COG1960	acyl-CoA dehydrogenase activity
I6G80_07875	COG1393	Belongs to the ArsC family
I6G80_07880	COG0509	glycine decarboxylation via glycine cleavage system
I6G80_07890	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6G80_07895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G80_07905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G80_07910	COG2011	ABC-type metal ion transport system permease component
I6G80_07915	COG1464	Belongs to the NlpA lipoprotein family
I6G80_07920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G80_07930	COG0396	ATPase activity
I6G80_07935	COG0719	Fe-S assembly protein
I6G80_07940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G80_07945	COG0822	iron-sulfur transferase activity
I6G80_07950	COG0719	Fe-S assembly protein
I6G80_07955	COG0457	Tetratricopeptide repeat
I6G80_07970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G80_07980	COG2356	endonuclease I
I6G80_07985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G80_07990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G80_07995	COG1288	antiporter activity
I6G80_08000	COG2814	Major facilitator Superfamily
I6G80_08005	COG2508	Transcriptional regulator
I6G80_08010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G80_08015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6G80_08025	COG3226	Transcriptional regulator
I6G80_08035	COG1801	Protein of unknown function DUF72
I6G80_08040	COG0730	response to heat
I6G80_08045	COG0737	Belongs to the 5'-nucleotidase family
I6G80_08050	COG3377	Domain of unknown function (DUF1805)
I6G80_08060	COG0733	neurotransmitter:sodium symporter activity
I6G80_08070	COG0739	heme binding
I6G80_08085	COG4470	Protein conserved in bacteria
I6G80_08090	COG2445	Protein of unknown function DUF86
I6G80_08095	COG0647	UMP catabolic process
I6G80_08100	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G80_08105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G80_08115	COG0460	homoserine dehydrogenase
I6G80_08120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G80_08125	COG0083	homoserine kinase activity
I6G80_08130	COG1506	peptidase
I6G80_08130	COG0823	Involved in the tonB-independent uptake of proteins
I6G80_08130	COG4946	Tricorn protease homolog
I6G80_08135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6G80_08140	COG4837	Protein of unknown function (DUF1462)
I6G80_08150	COG3479	Phenolic acid decarboxylase
I6G80_08155	COG0457	Tetratricopeptide repeat
I6G80_08165	COG5646	InterPro IPR014922
I6G80_08170	COG1252	NADH dehydrogenase
I6G80_08175	COG4844	belongs to the
I6G80_08180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G80_08185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6G80_08190	COG0316	Belongs to the HesB IscA family
I6G80_08195	COG0456	acetyltransferase
I6G80_08210	COG0492	ferredoxin-NADP+ reductase activity
I6G80_08215	COG1252	NADH dehydrogenase
I6G80_08230	COG3584	3D domain protein
I6G80_08235	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I6G80_08240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G80_08245	COG2056	Na+-H+ antiporter family
I6G80_08250	COG1268	BioY protein
I6G80_08255	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G80_08265	COG0686	Belongs to the AlaDH PNT family
I6G80_08270	COG2508	Transcriptional regulator
I6G80_08270	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6G80_08275	COG1115	amino acid carrier protein
I6G80_08280	COG4842	Belongs to the WXG100 family
I6G80_08285	COG5417	Belongs to the EsaB family
I6G80_08290	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6G80_08295	COG1674	ftsk spoiiie
I6G80_08295	COG0433	COG0433 Predicted ATPase
I6G80_08300	COG1511	domain protein
I6G80_08310	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_08315	COG1418	mRNA catabolic process
I6G80_08330	COG1959	2 iron, 2 sulfur cluster binding
I6G80_08335	COG0628	permease
I6G80_08350	COG5506	Protein of unknown function (DUF1694)
I6G80_08355	COG1335	isochorismatase
I6G80_08360	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G80_08365	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6G80_08390	COG4585	Histidine kinase
I6G80_08405	COG2197	response regulator
I6G80_08410	COG2050	protein possibly involved in aromatic compounds catabolism
I6G80_08415	COG1320	monovalent cation:proton antiporter activity
I6G80_08420	COG2212	antiporter activity
I6G80_08425	COG1863	multisubunit Na H antiporter MnhE subunit
I6G80_08430	COG0651	ATP synthesis coupled electron transport
I6G80_08435	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G80_08440	COG2111	Na H antiporter
I6G80_08445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G80_08445	COG2111	Na H antiporter
I6G80_08455	COG3493	citrate carrier protein
I6G80_08460	COG0688	phosphatidylethanolamine metabolic process
I6G80_08465	COG0586	Pfam SNARE associated Golgi protein
I6G80_08470	COG1183	phosphatidylcholine synthase activity
I6G80_08480	COG4565	transcriptional regulatory protein
I6G80_08485	COG3290	protein histidine kinase activity
I6G80_08495	COG3011	Protein conserved in bacteria
I6G80_08500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G80_08505	COG2814	Major facilitator Superfamily
I6G80_08510	COG5018	Exonuclease
I6G80_08525	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G80_08540	COG2267	carboxylic ester hydrolase activity
I6G80_08545	COG1522	sequence-specific DNA binding
I6G80_08550	COG0436	Aminotransferase
I6G80_08555	COG1098	S1 RNA binding domain
I6G80_08560	COG2155	Conserved Protein
I6G80_08565	COG1979	alcohol dehydrogenase
I6G80_08570	COG0166	Belongs to the GPI family
I6G80_08705	COG4626	Terminase
I6G80_08705	COG1802	Transcriptional regulator
I6G80_08780	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G80_08855	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I6G80_08860	COG2323	membrane
I6G80_08870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G80_08880	COG2738	Putative neutral zinc metallopeptidase
I6G80_08885	COG1253	flavin adenine dinucleotide binding
I6G80_08890	COG5297	Belongs to the glycosyl hydrolase family 6
I6G80_08905	COG0366	Alpha amylase catalytic
I6G80_08910	COG0432	Pfam Uncharacterised protein family UPF0047
I6G80_08915	COG2070	2-Nitropropane dioxygenase
I6G80_08925	COG0840	transmembrane signaling receptor activity
I6G80_08930	COG0840	transmembrane signaling receptor activity
I6G80_08935	COG0840	transmembrane signaling receptor activity
I6G80_08940	COG0693	protein deglycase activity
I6G80_08945	COG0673	inositol 2-dehydrogenase activity
I6G80_08950	COG0628	permease
I6G80_08955	COG1968	undecaprenyl-diphosphatase activity
I6G80_08960	COG1408	metallophosphoesterase
I6G80_08965	COG0726	polysaccharide deacetylase
I6G80_08970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G80_08985	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I6G80_09020	COG1397	ADP-ribosylglycohydrolase
I6G80_09055	COG2140	Oxalate decarboxylase
I6G80_09060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G80_09065	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6G80_09075	COG1510	regulation of RNA biosynthetic process
I6G80_09080	COG1012	belongs to the aldehyde dehydrogenase family
I6G80_09085	COG1454	alcohol dehydrogenase
I6G80_09095	COG2318	DinB family
I6G80_09105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G80_09110	COG0569	domain protein
I6G80_09115	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6G80_09120	COG0457	Tetratricopeptide repeat
I6G80_09135	COG3764	Sortase (surface protein transpeptidase)
I6G80_09140	COG3859	Proton-coupled thiamine transporter YuaJ
I6G80_09145	COG1609	Transcriptional regulator
I6G80_09265	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G80_09270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G80_09275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G80_09285	COG0058	SHG alpha-glucan phosphorylase activity
I6G80_09290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G80_09295	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G80_09300	COG1169	isochorismate synthase
I6G80_09305	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6G80_09310	COG0596	Alpha beta hydrolase
I6G80_09315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G80_09320	COG0318	PFAM AMP-dependent synthetase and ligase
I6G80_09325	COG4948	Mandelate Racemase Muconate Lactonizing
I6G80_09340	COG1294	oxidase, subunit
I6G80_09345	COG1271	oxidase subunit
I6G80_09350	COG0254	rRNA binding
I6G80_09355	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G80_09360	COG0523	cobalamin synthesis protein
I6G80_09365	COG0288	reversible hydration of carbon dioxide
I6G80_09370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G80_09375	COG1854	S-ribosylhomocysteine lyase activity
I6G80_09390	COG0783	Belongs to the Dps family
I6G80_09395	COG4824	toxin secretion phage lysis holin
I6G80_09405	COG0494	nUDIX hydrolase
I6G80_09410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G80_09415	COG1116	anion transmembrane transporter activity
I6G80_09420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G80_09425	COG1506	peptidase
I6G80_09435	COG1301	dicarboxylic acid transport
I6G80_09440	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6G80_09445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G80_09450	COG0367	asparagine synthase
I6G80_09455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G80_09455	COG0438	transferase activity, transferring glycosyl groups
I6G80_09460	COG0671	phosphoesterase, PA-phosphatase related
I6G80_09465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G80_09470	COG2267	carboxylic ester hydrolase activity
I6G80_09480	COG1301	dicarboxylic acid transport
I6G80_09485	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6G80_09490	COG1242	4 iron, 4 sulfur cluster binding
I6G80_09505	COG1725	Transcriptional regulator
I6G80_09510	COG1131	(ABC) transporter
I6G80_09520	COG1136	(ABC) transporter
I6G80_09525	COG0577	efflux transmembrane transporter activity
I6G80_09530	COG2433	Pfam Transposase IS66
I6G80_09540	COG2814	Major facilitator Superfamily
I6G80_09550	COG0495	leucyl-tRNA aminoacylation
I6G80_09555	COG0346	lactoylglutathione lyase activity
I6G80_09560	COG0583	DNA-binding transcription factor activity
I6G80_09570	COG1073	alpha beta
I6G80_09575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G80_09580	COG0395	ABC-type sugar transport system, permease component
I6G80_09585	COG1653	transport
I6G80_09590	COG2207	Transcriptional regulator
I6G80_09595	COG4209	transmembrane transport
I6G80_09600	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6G80_09605	COG1653	transport
I6G80_09610	COG0673	inositol 2-dehydrogenase activity
I6G80_09615	COG5578	integral membrane protein
I6G80_09630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G80_09640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G80_09645	COG2081	HI0933 family
I6G80_09650	COG2244	polysaccharide biosynthetic process
I6G80_09655	COG1187	pseudouridine synthase activity
I6G80_09660	COG1349	DNA-binding transcription factor activity
I6G80_09665	COG2252	PERMEase
I6G80_09670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G80_09685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G80_09690	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6G80_09700	COG1597	lipid kinase activity
I6G80_09705	COG1523	belongs to the glycosyl hydrolase 13 family
I6G80_09710	COG0510	thiamine kinase activity
I6G80_09720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G80_09725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G80_09730	COG0281	malic enzyme
I6G80_09735	COG5584	Small secreted protein
I6G80_09740	COG1363	Peptidase, m42
I6G80_09750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G80_09755	COG4848	Belongs to the UPF0354 family
I6G80_09760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G80_09765	COG1674	ftsk spoiiie
I6G80_09770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G80_09775	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I6G80_09780	COG4980	gas vesicle protein
I6G80_09785	COG3118	belongs to the thioredoxin family
I6G80_09795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6G80_09795	COG1605	Chorismate mutase
I6G80_09800	COG1609	Transcriptional regulator
I6G80_09805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G80_09810	COG1360	Flagellar Motor Protein
I6G80_09815	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6G80_09820	COG0517	IMP dehydrogenase activity
I6G80_09825	COG0454	-acetyltransferase
I6G80_09830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G80_09835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G80_09845	COG1522	sequence-specific DNA binding
I6G80_09850	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6G80_09855	COG3152	Membrane
I6G80_09865	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G80_09870	COG2203	Gaf domain
I6G80_09870	COG2199	diguanylate cyclase activity
I6G80_09875	COG1956	GAF domain-containing protein
I6G80_09880	COG1309	transcriptional regulator
I6G80_09885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G80_09890	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6G80_09895	COG1114	Component of the transport system for branched-chain amino acids
I6G80_09900	COG1104	cysteine desulfurase activity
I6G80_09905	COG0301	tRNA thio-modification
I6G80_09915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G80_09925	COG0477	Major facilitator Superfamily
I6G80_09930	COG1566	PFAM secretion protein HlyD family protein
I6G80_09935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G80_09940	COG0616	signal peptide processing
I6G80_09945	COG1714	RDD family
I6G80_09955	COG3874	Sporulation protein YtfJ
I6G80_09960	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G80_09965	COG0827	DNA restriction-modification system
I6G80_09970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G80_09975	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G80_09980	COG0137	argininosuccinate synthase activity
I6G80_09985	COG0165	Argininosuccinate lyase
I6G80_09995	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_10000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6G80_10005	COG1695	Transcriptional regulator
I6G80_10010	COG4109	DRTGG domain
I6G80_10020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6G80_10040	COG0587	DNA-directed DNA polymerase activity
I6G80_10045	COG0281	malic enzyme
I6G80_10050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G80_10055	COG0825	malonyl-CoA metabolic process
I6G80_10060	COG0205	6-phosphofructokinase activity
I6G80_10070	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6G80_10075	COG0628	permease
I6G80_10080	COG2707	UPF0756 membrane protein
I6G80_10085	COG0372	Belongs to the citrate synthase family
I6G80_10090	COG0538	isocitrate dehydrogenase activity
I6G80_10095	COG0039	L-malate dehydrogenase activity
I6G80_10100	COG0745	RESPONSE REGULATOR receiver
I6G80_10105	COG5002	protein histidine kinase activity
I6G80_10110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G80_10110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G80_10115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G80_10120	COG1971	Probably functions as a manganese efflux pump
I6G80_10125	COG0237	dephospho-CoA kinase activity
I6G80_10130	COG3866	Pectate lyase
I6G80_10135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G80_10140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6G80_10150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6G80_10155	COG3611	Membrane attachment protein
I6G80_10160	COG1484	DNA-dependent DNA replication
I6G80_10165	COG0398	Pfam SNARE associated Golgi protein
I6G80_10175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G80_10180	COG1011	Hydrolase
I6G80_10190	COG3275	phosphorelay sensor kinase activity
I6G80_10195	COG3279	Response regulator of the LytR AlgR family
I6G80_10200	COG3540	Alkaline phosphatase
I6G80_10210	COG1346	cytolysis
I6G80_10215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6G80_10220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G80_10225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G80_10230	COG3326	Membrane
I6G80_10240	COG1363	Peptidase, m42
I6G80_10245	COG3507	Belongs to the glycosyl hydrolase 43 family
I6G80_10250	COG2160	L-arabinose isomerase activity
I6G80_10260	COG0235	Class ii aldolase
I6G80_10265	COG0371	Dehydrogenase
I6G80_10270	COG1653	transport
I6G80_10275	COG1175	transmembrane transport
I6G80_10280	COG0395	ABC-type sugar transport system, permease component
I6G80_10295	COG1966	Carbon starvation protein
I6G80_10305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G80_10310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G80_10315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G80_10315	COG0072	phenylalanine-tRNA ligase activity
I6G80_10330	COG1137	ATPase activity
I6G80_10345	COG0072	phenylalanine-tRNA ligase activity
I6G80_10345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G80_10360	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G80_10365	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6G80_10370	COG1286	toxin biosynthetic process
I6G80_10375	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G80_10375	COG1796	DNA polymerase
I6G80_10380	COG1193	negative regulation of DNA recombination
I6G80_10385	COG3766	membrane
I6G80_10390	COG0318	PFAM AMP-dependent synthetase and ligase
I6G80_10395	COG1309	transcriptional regulator
I6G80_10400	COG1024	Enoyl-CoA hydratase
I6G80_10405	COG2086	electron transfer activity
I6G80_10410	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6G80_10415	COG3118	belongs to the thioredoxin family
I6G80_10420	COG0322	excinuclease ABC activity
I6G80_10425	COG0527	aspartate kinase activity
I6G80_10430	COG1719	4-vinyl reductase, 4VR
I6G80_10435	COG2009	succinate dehydrogenase
I6G80_10440	COG1053	succinate dehydrogenase
I6G80_10445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G80_10450	COG0824	Thioesterase
I6G80_10455	COG4221	oxidoreductase activity
I6G80_10460	COG2197	response regulator
I6G80_10465	COG1846	Transcriptional regulator
I6G80_10470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G80_10475	COG5401	PFAM Sporulation and spore germination
I6G80_10480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6G80_10485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G80_10490	COG0622	Phosphoesterase
I6G80_10515	COG0457	Tetratricopeptide repeat
I6G80_10520	COG5444	nuclease activity
I6G80_10580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G80_10590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G80_10595	COG0028	Belongs to the TPP enzyme family
I6G80_10600	COG0440	acetolactate synthase activity
I6G80_10605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G80_10610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G80_10615	COG0473	3-isopropylmalate dehydrogenase activity
I6G80_10620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G80_10625	COG0066	3-isopropylmalate dehydratase activity
I6G80_10630	COG1477	protein flavinylation
I6G80_10630	COG0457	Tetratricopeptide repeat
I6G80_10635	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G80_10640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6G80_10645	COG0470	DNA polymerase III
I6G80_10645	COG1067	ATP-dependent peptidase activity
I6G80_10650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G80_10655	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6G80_10665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6G80_10670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G80_10675	COG0181	hydroxymethylbilane synthase activity
I6G80_10680	COG1587	Uroporphyrinogen-III synthase
I6G80_10685	COG0113	porphobilinogen synthase activity
I6G80_10690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G80_10695	COG1388	LysM domain
I6G80_10700	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G80_10710	COG0525	valine-tRNA ligase activity
I6G80_10715	COG0285	dihydrofolate synthase activity
I6G80_10720	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6G80_10730	COG0424	maF-like protein
I6G80_10735	COG2003	Belongs to the UPF0758 family
I6G80_10750	COG1396	sequence-specific DNA binding
I6G80_10860	COG4626	Terminase
I6G80_10860	COG1802	Transcriptional regulator
I6G80_10920	COG3953	SLT domain
I6G80_10920	COG5280	Phage tail tape measure protein TP901
I6G80_10930	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G80_10935	COG5434	Belongs to the glycosyl hydrolase 28 family
I6G80_10995	COG0457	Tetratricopeptide repeat
I6G80_11015	COG1077	Cell shape determining protein MreB Mrl
I6G80_11025	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6G80_11030	COG0850	regulation of cytokinetic process
I6G80_11035	COG2894	cell division
I6G80_11040	COG0640	Transcriptional regulator
I6G80_11045	COG3832	glyoxalase III activity
I6G80_11050	COG0739	heme binding
I6G80_11055	COG1994	Peptidase M50
I6G80_11060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G80_11065	COG2868	ribosomal protein
I6G80_11070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G80_11075	COG3290	protein histidine kinase activity
I6G80_11080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6G80_11085	COG4492	Belongs to the UPF0735 family
I6G80_11090	COG0077	Prephenate dehydratase
I6G80_11095	COG1827	regulation of RNA biosynthetic process
I6G80_11100	COG1104	cysteine desulfurase activity
I6G80_11105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6G80_11110	COG0157	Belongs to the NadC ModD family
I6G80_11115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6G80_11120	COG1388	LysM domain
I6G80_11130	COG0217	transcriptional regulatory protein
I6G80_11145	COG4195	phage-related replication protein
I6G80_11150	COG2318	DinB family
I6G80_11160	COG2112	serine threonine protein kinase
I6G80_11170	COG0632	four-way junction helicase activity
I6G80_11175	COG2255	four-way junction helicase activity
I6G80_11185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G80_11190	COG0343	queuine tRNA-ribosyltransferase activity
I6G80_11195	COG1862	Preprotein translocase
I6G80_11205	COG2323	membrane
I6G80_11210	COG2244	polysaccharide biosynthetic process
I6G80_11220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G80_11220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G80_11225	COG5416	Lipopolysaccharide assembly protein A domain
I6G80_11230	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G80_11230	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6G80_11235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G80_11240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G80_11245	COG1490	D-aminoacyl-tRNA deacylase activity
I6G80_11250	COG4991	sh3 domain protein
I6G80_11250	COG3103	Sh3 type 3 domain protein
I6G80_11250	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G80_11260	COG0124	histidyl-tRNA synthetase
I6G80_11265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G80_11275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G80_11280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G80_11285	COG1959	2 iron, 2 sulfur cluster binding
I6G80_11290	COG1104	cysteine desulfurase activity
I6G80_11295	COG0482	sulfurtransferase activity
I6G80_11300	COG0457	Tetratricopeptide repeat
I6G80_11305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G80_11310	COG3881	PFAM PRC-barrel domain
I6G80_11325	COG0628	permease
I6G80_11330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G80_11335	COG4472	Bacterial protein of unknown function (DUF965)
I6G80_11340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6G80_11345	COG3906	Belongs to the UPF0473 family
I6G80_11350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G80_11355	COG4122	O-methyltransferase activity
I6G80_11360	COG0826	peptidase U32
I6G80_11365	COG0826	peptidase U32
I6G80_11370	COG0572	uridine kinase
I6G80_11375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G80_11380	COG0768	penicillin binding
I6G80_11395	COG2226	methyltransferase
I6G80_11400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G80_11405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G80_11410	COG0626	cystathionine gamma-synthase activity
I6G80_11435	COG2226	methyltransferase
I6G80_11440	COG1404	Belongs to the peptidase S8 family
I6G80_11445	COG1309	transcriptional regulator
I6G80_11450	COG2124	cytochrome p450
I6G80_11450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G80_11460	COG2814	Major facilitator Superfamily
I6G80_11470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G80_11480	COG1587	Uroporphyrinogen-III synthase
I6G80_11485	COG3340	Belongs to the peptidase S51 family
I6G80_11490	COG1733	regulation of RNA biosynthetic process
I6G80_11495	COG2814	Major facilitator Superfamily
I6G80_11500	COG0656	L-ascorbic acid biosynthetic process
I6G80_11505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G80_11530	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6G80_11530	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6G80_11535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G80_11540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_11545	COG3715	PTS system
I6G80_11550	COG3716	PTS system mannose fructose sorbose family IID component
I6G80_11555	COG1621	beta-fructofuranosidase activity
I6G80_11560	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_11570	COG0730	response to heat
I6G80_11575	COG2124	cytochrome p450
I6G80_11590	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_11610	COG4608	Belongs to the ABC transporter superfamily
I6G80_11615	COG0444	Belongs to the ABC transporter superfamily
I6G80_11620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G80_11625	COG0601	transmembrane transport
I6G80_11630	COG0747	negative chemotaxis
I6G80_11635	COG0492	ferredoxin-NADP+ reductase activity
I6G80_11640	COG2197	response regulator
I6G80_11645	COG4585	Histidine kinase
I6G80_11655	COG1733	regulation of RNA biosynthetic process
I6G80_11660	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6G80_11665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G80_11670	COG0113	porphobilinogen synthase activity
I6G80_11675	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G80_11720	COG1937	Protein conserved in bacteria
I6G80_11725	COG2210	Belongs to the sulfur carrier protein TusA family
I6G80_11730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G80_11730	COG0425	Belongs to the sulfur carrier protein TusA family
I6G80_11735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G80_11735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G80_11740	COG0425	Belongs to the sulfur carrier protein TusA family
I6G80_11745	COG0730	response to heat
I6G80_11750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G80_11755	COG4585	Histidine kinase
I6G80_11760	COG2197	response regulator
I6G80_11840	COG0577	efflux transmembrane transporter activity
I6G80_11845	COG1136	(ABC) transporter
I6G80_11890	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G80_11925	COG2427	Protein of unknown function (DUF1641)
I6G80_11930	COG3383	formate dehydrogenase (NAD+) activity
I6G80_11935	COG5609	conserved protein (DUF2294)
I6G80_11940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G80_11945	COG2755	lipolytic protein G-D-S-L family
I6G80_11960	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6G80_11965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G80_11970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G80_11975	COG1534	Rna-binding protein
I6G80_11980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G80_11985	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6G80_11990	COG0799	negative regulation of ribosome biogenesis
I6G80_11995	COG2226	methyltransferase
I6G80_12000	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G80_12005	COG1555	photosystem II stabilization
I6G80_12005	COG1596	polysaccharide export
I6G80_12010	COG2131	deaminase
I6G80_12015	COG0658	competence protein
I6G80_12015	COG2333	competence protein COMEC
I6G80_12025	COG1466	dna polymerase III delta subunit
I6G80_12030	COG0268	Binds directly to 16S ribosomal RNA
I6G80_12035	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G80_12040	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G80_12050	COG0481	GTPase activity
I6G80_12055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G80_12060	COG1420	regulation of RNA biosynthetic process
I6G80_12065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G80_12070	COG0443	Heat shock 70 kDa protein
I6G80_12075	COG0484	heat shock protein binding
I6G80_12080	COG2264	protein methyltransferase activity
I6G80_12085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G80_12090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G80_12095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G80_12100	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6G80_12105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G80_12110	COG1610	YqeY-like protein
I6G80_12115	COG1030	water channel activity
I6G80_12120	COG4864	UPF0365 protein
I6G80_12135	COG0561	phosphatase activity
I6G80_12140	COG1702	phosphate starvation-inducible protein PhoH
I6G80_12145	COG1480	7TM receptor with intracellular HD hydrolase
I6G80_12150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G80_12155	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G80_12160	COG0295	cytidine deaminase activity
I6G80_12165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G80_12175	COG1381	Involved in DNA repair and RecF pathway recombination
I6G80_12180	COG0752	glycyl-tRNA synthetase alpha subunit
I6G80_12185	COG0751	glycine-tRNA ligase activity
I6G80_12190	COG0517	IMP dehydrogenase activity
I6G80_12195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G80_12200	COG1671	Belongs to the UPF0178 family
I6G80_12205	COG0358	DNA primase activity
I6G80_12210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G80_12215	COG2010	Cytochrome c
I6G80_12230	COG5444	nuclease activity
I6G80_12275	COG2384	SAM-dependent methyltransferase
I6G80_12280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G80_12285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G80_12295	COG0513	Belongs to the DEAD box helicase family
I6G80_12300	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6G80_12310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G80_12315	COG1121	(ABC) transporter
I6G80_12320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G80_12325	COG0735	belongs to the Fur family
I6G80_12330	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I6G80_12335	COG4709	membrane
I6G80_12340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6G80_12345	COG1388	LysM domain
I6G80_12350	COG5521	maltodextrose utilization protein MalA
I6G80_12355	COG2839	Protein conserved in bacteria
I6G80_12360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G80_12365	COG0477	Major facilitator Superfamily
I6G80_12370	COG0768	penicillin binding
I6G80_12375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G80_12380	COG0573	inorganic phosphate transmembrane transporter activity
I6G80_12385	COG0581	inorganic phosphate transmembrane transporter activity
I6G80_12390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G80_12395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G80_12400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G80_12415	COG0438	transferase activity, transferring glycosyl groups
I6G80_12420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G80_12425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G80_12435	COG0457	Tetratricopeptide repeat
I6G80_12435	COG0705	Rhomboid family
I6G80_12440	COG0697	spore germination
I6G80_12445	COG4483	Protein conserved in bacteria
I6G80_12450	COG1940	carbohydrate kinase activity
I6G80_12455	COG1368	sulfuric ester hydrolase activity
I6G80_12465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G80_12470	COG2866	Carboxypeptidase
I6G80_12480	COG0011	TIGRFAM Protein of
I6G80_12490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G80_12500	COG1393	Belongs to the ArsC family
I6G80_12510	COG1366	Belongs to the anti-sigma-factor antagonist family
I6G80_12515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G80_12520	COG1459	type II secretion system
I6G80_12525	COG4537	Required for transformation and DNA binding
I6G80_12530	COG4970	Tfp pilus assembly protein FimT
I6G80_12540	COG4940	Competence protein ComGF
I6G80_12565	COG0681	Belongs to the peptidase S26 family
I6G80_12590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G80_12595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G80_12600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G80_12605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G80_12610	COG4175	Glycine betaine
I6G80_12610	COG0517	IMP dehydrogenase activity
I6G80_12615	COG4176	ABC-type proline glycine betaine transport system permease component
I6G80_12620	COG2113	Glycine betaine
I6G80_12625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G80_12630	COG0095	Lipoate-protein ligase
I6G80_12635	COG1321	iron dependent repressor
I6G80_12640	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G80_12650	COG3872	metal-dependent enzyme
I6G80_12660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6G80_12665	COG0006	proline dipeptidase activity
I6G80_12670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G80_12680	COG3854	ATPases associated with a variety of cellular activities
I6G80_12720	COG0511	ligase activity, forming carbon-carbon bonds
I6G80_12725	COG0439	Biotin carboxylase
I6G80_12730	COG1302	Protein conserved in bacteria
I6G80_12735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G80_12740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G80_12745	COG1570	exodeoxyribonuclease VII activity
I6G80_12750	COG1722	exodeoxyribonuclease VII activity
I6G80_12755	COG0142	geranyltranstransferase activity
I6G80_12760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6G80_12765	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6G80_12770	COG1438	arginine binding
I6G80_12775	COG0497	DNA recombination
I6G80_12780	COG0750	zinc metalloprotease
I6G80_12785	COG0745	RESPONSE REGULATOR receiver
I6G80_12795	COG1045	serine acetyltransferase
I6G80_12810	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G80_12815	COG0584	glycerophosphoryl diester phosphodiesterase
I6G80_12825	COG3290	protein histidine kinase activity
I6G80_12825	COG3829	transcription factor binding
I6G80_12830	COG0280	phosphate acetyltransferase
I6G80_12840	COG3426	butyrate kinase activity
I6G80_12845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G80_12850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G80_12855	COG0022	dehydrogenase e1 component
I6G80_12860	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G80_12865	COG1597	lipid kinase activity
I6G80_12880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G80_12885	COG0765	amino acid transport
I6G80_12890	COG1126	abc transporter atp-binding protein
I6G80_12895	COG4129	membrane
I6G80_12905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G80_12910	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G80_12915	COG0706	membrane insertase activity
I6G80_12925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G80_12930	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G80_12935	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_12940	COG1785	Belongs to the alkaline phosphatase family
I6G80_12945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G80_12950	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G80_12955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G80_12960	COG2723	6-phospho-beta-galactosidase activity
I6G80_12965	COG2188	Transcriptional regulator
I6G80_12970	COG2358	TRAP transporter, solute receptor (TAXI family
I6G80_12985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G80_12990	COG1234	tRNA 3'-trailer cleavage
I6G80_12995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G80_13000	COG0596	Alpha beta hydrolase
I6G80_13005	COG1902	pentaerythritol trinitrate reductase activity
I6G80_13010	COG4187	Peptidase family M20/M25/M40
I6G80_13015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G80_13020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G80_13025	COG0300	oxidoreductase activity
I6G80_13030	COG4195	phage-related replication protein
I6G80_13050	COG1131	(ABC) transporter
I6G80_13060	COG1072	(Pantothenic acid kinase))
I6G80_13065	COG0346	lactoylglutathione lyase activity
I6G80_13070	COG2211	Major facilitator Superfamily
I6G80_13080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G80_13095	COG0534	Mate efflux family protein
I6G80_13105	COG0444	Belongs to the ABC transporter superfamily
I6G80_13115	COG0601	transmembrane transport
I6G80_13120	COG0747	negative chemotaxis
I6G80_13130	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6G80_13135	COG2329	Antibiotic biosynthesis monooxygenase
I6G80_13150	COG4918	Iron-sulphur cluster biosynthesis
I6G80_13160	COG1073	alpha beta
I6G80_13170	COG0667	Aldo Keto reductase
I6G80_13180	COG1309	transcriptional regulator
I6G80_13190	COG0494	nUDIX hydrolase
I6G80_13195	COG1379	DNA repair
I6G80_13200	COG2153	protein acetylation
I6G80_13220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G80_13225	COG1300	Membrane
I6G80_13230	COG0735	belongs to the Fur family
I6G80_13240	COG4974	Belongs to the 'phage' integrase family
I6G80_13245	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6G80_13250	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6G80_13255	COG1686	Belongs to the peptidase S11 family
I6G80_13290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G80_13305	COG0697	spore germination
I6G80_13315	COG0019	diaminopimelate decarboxylase activity
I6G80_13320	COG4195	phage-related replication protein
I6G80_13325	COG4086	secreted protein
I6G80_13330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G80_13335	COG0457	Tetratricopeptide repeat
I6G80_13360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G80_13360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G80_13365	COG0307	riboflavin synthase, alpha
I6G80_13370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G80_13370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G80_13375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G80_13380	COG0456	acetyltransferase
I6G80_13385	COG1547	Domain of unknown function (DUF309)
I6G80_13395	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6G80_13400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G80_13410	COG1686	Belongs to the peptidase S11 family
I6G80_13415	COG2715	membrane protein required for spore maturation
I6G80_13420	COG0700	Nucleoside recognition
I6G80_13425	COG1187	pseudouridine synthase activity
I6G80_13430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G80_13435	COG1333	cytochrome c biogenesis protein
I6G80_13440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G80_13445	COG0745	RESPONSE REGULATOR receiver
I6G80_13450	COG5002	protein histidine kinase activity
I6G80_13455	COG0745	RESPONSE REGULATOR receiver
I6G80_13460	COG5002	protein histidine kinase activity
I6G80_13475	COG1316	TRANSCRIPTIONal
I6G80_13480	COG1595	DNA-templated transcription, initiation
I6G80_13490	COG0739	heme binding
I6G80_13495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G80_13500	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6G80_13505	COG1141	Ferredoxin
I6G80_13510	COG4955	Helix-turn-helix domain
I6G80_13515	COG0514	ATP-dependent DNA helicase (RecQ)
I6G80_13520	COG1266	CAAX protease self-immunity
I6G80_13525	COG1388	LysM domain
I6G80_13535	COG1408	metallophosphoesterase
I6G80_13540	COG4862	establishment of competence for transformation
I6G80_13545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G80_13550	COG0492	ferredoxin-NADP+ reductase activity
I6G80_13560	COG2339	peptidase activity
I6G80_13565	COG3773	Cell wall hydrolase
I6G80_13565	COG3409	Peptidoglycan-binding domain 1 protein
I6G80_13570	COG2959	enzyme of heme biosynthesis
I6G80_13580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G80_13585	COG0539	negative regulation of cytoplasmic translation
I6G80_13590	COG1304	FMN binding
I6G80_13615	COG1160	GTP binding
I6G80_13620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G80_13635	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G80_13640	COG0776	regulation of translation
I6G80_13655	COG0142	geranyltranstransferase activity
I6G80_13660	COG2226	methyltransferase
I6G80_13665	COG0142	geranyltranstransferase activity
I6G80_13670	COG0105	UTP biosynthetic process
I6G80_13675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G80_13680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6G80_13685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6G80_13690	COG4401	Chorismate mutase type I
I6G80_13695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G80_13700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G80_13705	COG0134	indole-3-glycerol-phosphate synthase activity
I6G80_13710	COG0135	phosphoribosylanthranilate isomerase activity
I6G80_13715	COG0133	tryptophan synthase activity
I6G80_13720	COG0159	tryptophan synthase activity
I6G80_13725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G80_13730	COG0287	Prephenate dehydrogenase
I6G80_13735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G80_13740	COG0457	Tetratricopeptide repeat
I6G80_13745	COG5582	Belongs to the UPF0302 family
I6G80_13755	COG0723	plastoquinol--plastocyanin reductase activity
I6G80_13760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G80_13765	COG2010	Cytochrome c
I6G80_13765	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G80_13775	COG4347	Protein of unknown function (DUF1405)
I6G80_13785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G80_13790	COG1694	Mazg nucleotide pyrophosphohydrolase
I6G80_13795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G80_13800	COG1803	Methylglyoxal synthase
I6G80_13805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G80_13810	COG0438	transferase activity, transferring glycosyl groups
I6G80_13815	COG0617	tRNA 3'-terminal CCA addition
I6G80_13825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6G80_13830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G80_13835	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6G80_13840	COG1199	ATP-dependent helicase activity
I6G80_13840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G80_13850	COG5353	protein conserved in bacteria
I6G80_13855	COG0436	Aminotransferase
I6G80_13860	COG0017	Asparaginyl-tRNA synthetase
I6G80_13865	COG3935	DnaD domain protein
I6G80_13870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G80_13880	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6G80_13880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G80_13885	COG3331	DNA recombination
I6G80_13925	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G80_13930	COG2190	(PTS) system
I6G80_13935	COG1205	dead DEAH box helicase
I6G80_13935	COG1111	helicase
I6G80_13940	COG3359	exonuclease
I6G80_13950	COG4474	Belongs to the UPF0398 family
I6G80_13955	COG3599	regulation of cell shape
I6G80_13965	COG0116	Belongs to the methyltransferase superfamily
I6G80_13980	COG1199	ATP-dependent helicase activity
I6G80_13985	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6G80_13990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G80_13995	COG2233	PERMEase
I6G80_14000	COG0456	acetyltransferase
I6G80_14005	COG3424	synthase
I6G80_14010	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6G80_14020	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G80_14035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G80_14045	COG0328	RNA-DNA hybrid ribonuclease activity
I6G80_14050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6G80_14055	COG0328	RNA-DNA hybrid ribonuclease activity
I6G80_14075	COG1278	Cold shock
I6G80_14085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G80_14090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6G80_14095	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6G80_14100	COG0386	Belongs to the glutathione peroxidase family
I6G80_14105	COG1418	mRNA catabolic process
I6G80_14110	COG1413	lyase activity
I6G80_14120	COG0129	dihydroxy-acid dehydratase activity
I6G80_14130	COG2136	Putative SAM-dependent methyltransferase
I6G80_14130	COG2521	methyltransferase
I6G80_14140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G80_14145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G80_14150	COG0204	Acyl-transferase
I6G80_14155	COG1272	protein, Hemolysin III
I6G80_14160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6G80_14165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G80_14180	COG1999	signal sequence binding
I6G80_14185	COG2755	lipolytic protein G-D-S-L family
I6G80_14190	COG4698	Protein conserved in bacteria
I6G80_14205	COG0534	Mate efflux family protein
I6G80_14210	COG3706	GGDEF domain
I6G80_14220	COG1846	Transcriptional regulator
I6G80_14225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G80_14230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G80_14235	COG0456	acetyltransferase
I6G80_14250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G80_14255	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G80_14260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G80_14265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G80_14270	COG0456	acetyltransferase
I6G80_14275	COG1509	lysine 2,3-aminomutase activity
I6G80_14280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G80_14290	COG4282	regulation of fungal-type cell wall biogenesis
I6G80_14295	COG5444	nuclease activity
I6G80_14325	COG2814	Major facilitator Superfamily
I6G80_14330	COG0457	Tetratricopeptide repeat
I6G80_14350	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6G80_14355	COG5434	Belongs to the glycosyl hydrolase 28 family
I6G80_14365	COG2433	Pfam Transposase IS66
I6G80_14375	COG1196	nuclear chromosome segregation
I6G80_14375	COG0739	heme binding
I6G80_14375	COG0741	lytic transglycosylase activity
I6G80_14380	COG0739	heme binding
I6G80_14380	COG0741	lytic transglycosylase activity
I6G80_14380	COG1196	nuclear chromosome segregation
I6G80_14385	COG0739	heme binding
I6G80_14385	COG1196	nuclear chromosome segregation
I6G80_14385	COG0741	lytic transglycosylase activity
I6G80_14450	COG0582	viral genome integration into host DNA
I6G80_14545	COG4373	Mu-like prophage FluMu protein gp28
I6G80_14680	COG3655	Transcriptional regulator
I6G80_14770	COG1404	Belongs to the peptidase S8 family
I6G80_14800	COG0582	viral genome integration into host DNA
I6G80_14825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G80_14830	COG4474	Belongs to the UPF0398 family
I6G80_14865	COG1793	dna ligase
I6G80_14925	COG2887	Belongs to the helicase family. UvrD subfamily
I6G80_14935	COG0305	Participates in initiation and elongation during chromosome replication
I6G80_14940	COG0358	DNA primase activity
I6G80_14945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G80_14950	COG0587	DNA-directed DNA polymerase activity
I6G80_14965	COG3584	3D domain protein
I6G80_15050	COG1780	Probably involved in ribonucleotide reductase function
I6G80_15055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G80_15065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G80_15075	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6G80_15080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G80_15090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G80_15105	COG0756	dUTP diphosphatase activity
I6G80_15125	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6G80_15200	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
I6G80_15205	COG3331	DNA recombination
I6G80_15225	COG4479	Belongs to the UPF0346 family
I6G80_15240	COG0671	phosphoesterase, PA-phosphatase related
I6G80_15260	COG0701	Predicted permease
I6G80_15265	COG0813	purine-nucleoside phosphorylase activity
I6G80_15270	COG1876	peptidase activity
I6G80_15280	COG2226	methyltransferase
I6G80_15285	COG3409	Peptidoglycan-binding domain 1 protein
I6G80_15285	COG0793	Belongs to the peptidase S41A family
I6G80_15295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G80_15305	COG0400	carboxylic ester hydrolase activity
I6G80_15310	COG0778	Nitroreductase
I6G80_15315	COG1733	regulation of RNA biosynthetic process
I6G80_15320	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_15330	COG4305	rare lipoprotein A
I6G80_15340	COG2962	Rard protein
I6G80_15350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G80_15355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G80_15360	COG0534	Mate efflux family protein
I6G80_15365	COG0791	NLP P60 protein
I6G80_15365	COG1388	LysM domain
I6G80_15370	COG2032	superoxide dismutase activity
I6G80_15375	COG0714	Associated with various cellular activities
I6G80_15380	COG4548	von Willebrand factor, type A
I6G80_15385	COG0567	Dehydrogenase, E1 component
I6G80_15390	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G80_15395	COG0385	Bile acid
I6G80_15400	COG0733	neurotransmitter:sodium symporter activity
I6G80_15410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G80_15415	COG1657	PFAM Prenyltransferase squalene oxidase
I6G80_15430	COG2814	Major facilitator Superfamily
I6G80_15435	COG1012	belongs to the aldehyde dehydrogenase family
I6G80_15450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G80_15455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6G80_15460	COG2318	DinB family
I6G80_15475	COG1309	transcriptional regulator
I6G80_15480	COG0574	Belongs to the PEP-utilizing enzyme family
I6G80_15480	COG3848	Pyruvate phosphate dikinase
I6G80_15490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G80_15495	COG1280	lysine exporter protein (LysE YggA)
I6G80_15510	COG2267	carboxylic ester hydrolase activity
I6G80_15525	COG0402	S-adenosylhomocysteine deaminase activity
I6G80_15565	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6G80_15590	COG2427	Protein of unknown function (DUF1641)
I6G80_15605	COG2315	Protein conserved in bacteria
I6G80_15625	COG0514	ATP-dependent DNA helicase (RecQ)
I6G80_15630	COG3584	3D domain protein
I6G80_15630	COG1388	LysM domain
I6G80_15635	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G80_15650	COG2322	membrane
I6G80_15670	COG1086	Polysaccharide biosynthesis protein
I6G80_15675	COG0741	lytic transglycosylase activity
I6G80_15680	COG0531	amino acid
I6G80_15690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G80_15695	COG0640	Transcriptional regulator
I6G80_15705	COG2378	regulation of single-species biofilm formation
I6G80_15715	COG3708	Transcriptional regulator
I6G80_15720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G80_15725	COG1309	transcriptional regulator
I6G80_15755	COG1846	Transcriptional regulator
I6G80_15760	COG1309	transcriptional regulator
I6G80_15770	COG1404	Belongs to the peptidase S8 family
I6G80_15775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G80_15780	COG0840	transmembrane signaling receptor activity
I6G80_15785	COG0488	(ABC) transporter
I6G80_15790	COG0697	spore germination
I6G80_15795	COG0531	amino acid
I6G80_15800	COG0531	amino acid
I6G80_15810	COG0531	amino acid
I6G80_15820	COG1846	Transcriptional regulator
I6G80_15825	COG0243	molybdopterin cofactor binding
I6G80_15830	COG0477	Major facilitator Superfamily
I6G80_15835	COG3848	Pyruvate phosphate dikinase
I6G80_15835	COG0574	Belongs to the PEP-utilizing enzyme family
I6G80_15840	COG0300	oxidoreductase activity
I6G80_15850	COG1132	(ABC) transporter
I6G80_15860	COG1846	Transcriptional regulator
I6G80_15880	COG0583	DNA-binding transcription factor activity
I6G80_15885	COG0070	glutamate synthase
I6G80_15885	COG0069	glutamate synthase activity
I6G80_15885	COG0067	glutamate synthase
I6G80_15890	COG0493	'glutamate synthase
I6G80_15900	COG0463	Glycosyl transferase, family 2
I6G80_15905	COG2814	Major facilitator Superfamily
I6G80_15910	COG4948	Mandelate Racemase Muconate Lactonizing
I6G80_15915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G80_15920	COG1809	phosphosulfolactate synthase activity
I6G80_15925	COG0175	sulfate reduction
I6G80_15930	COG0306	phosphate transporter
I6G80_15940	COG2323	membrane
I6G80_15950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G80_15955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G80_15960	COG1733	regulation of RNA biosynthetic process
I6G80_15965	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G80_15970	COG1960	acyl-CoA dehydrogenase activity
I6G80_15975	COG0318	PFAM AMP-dependent synthetase and ligase
I6G80_15980	COG0439	Biotin carboxylase
I6G80_15985	COG0511	ligase activity, forming carbon-carbon bonds
I6G80_15990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G80_15995	COG1024	Enoyl-CoA hydratase
I6G80_16000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G80_16005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G80_16015	COG0166	Belongs to the GPI family
I6G80_16025	COG1252	NADH dehydrogenase
I6G80_16030	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G80_16040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G80_16045	COG2404	hydrolase activity, acting on ester bonds
I6G80_16050	COG1649	PFAM Uncharacterised BCR, COG1649
I6G80_16065	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I6G80_16070	COG0640	Transcriptional regulator
I6G80_16075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G80_16080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G80_16085	COG1609	Transcriptional regulator
I6G80_16095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6G80_16110	COG1312	Catalyzes the dehydration of D-mannonate
I6G80_16115	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_16120	COG1725	Transcriptional regulator
I6G80_16135	COG3711	transcriptional antiterminator
I6G80_16135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G80_16155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G80_16155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G80_16155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G80_16160	COG1482	cell wall glycoprotein biosynthetic process
I6G80_16165	COG1960	acyl-CoA dehydrogenase activity
I6G80_16170	COG2084	Dehydrogenase
I6G80_16175	COG1012	belongs to the aldehyde dehydrogenase family
I6G80_16180	COG1024	Enoyl-CoA hydratase
I6G80_16205	COG0789	Transcriptional regulator
I6G80_16215	COG1114	Component of the transport system for branched-chain amino acids
I6G80_16220	COG3420	alginic acid biosynthetic process
I6G80_16235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G80_16245	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I6G80_16255	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6G80_16275	COG2223	nitrite transmembrane transporter activity
I6G80_16280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G80_16290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G80_16295	COG0535	radical SAM domain protein
I6G80_16310	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G80_16315	COG1140	nitrate reductase beta subunit
I6G80_16320	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G80_16325	COG2181	nitrate reductase activity
I6G80_16335	COG1115	amino acid carrier protein
I6G80_16355	COG2160	L-arabinose isomerase activity
I6G80_16370	COG1609	Transcriptional regulator
I6G80_16375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G80_16380	COG0187	DNA topoisomerase II activity
I6G80_16385	COG1832	CoA-binding protein
I6G80_16390	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6G80_16395	COG4841	protein insertion into membrane
I6G80_16420	COG0824	Thioesterase
I6G80_16440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G80_16445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G80_16460	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G80_16470	COG4846	Membrane protein involved in cytochrome C biogenesis
I6G80_16475	COG2201	protein-glutamate methylesterase activity
I6G80_16480	COG0785	Cytochrome C biogenesis protein
I6G80_16490	COG3763	UPF0154 protein
I6G80_16500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G80_16505	COG4224	UPF0291 protein
I6G80_16510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G80_16515	COG1388	LysM domain
I6G80_16520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G80_16525	COG3209	COG3209 Rhs family protein
I6G80_16550	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6G80_16555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G80_16560	COG0346	lactoylglutathione lyase activity
I6G80_16565	COG0778	Nitroreductase
I6G80_16570	COG1846	Transcriptional regulator
I6G80_16595	COG3546	catalase activity
I6G80_16615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G80_16620	COG2076	Multidrug Resistance protein
I6G80_16625	COG2076	Multidrug Resistance protein
I6G80_16630	COG1309	transcriptional regulator
I6G80_16675	COG1073	alpha beta
I6G80_16710	COG0174	glutamine synthetase
I6G80_16715	COG0789	Transcriptional regulator
I6G80_16720	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6G80_16725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G80_16730	COG0464	growth
I6G80_16780	COG1309	transcriptional regulator
I6G80_16810	COG0697	spore germination
I6G80_16815	COG1802	Transcriptional regulator
I6G80_16820	COG0735	belongs to the Fur family
I6G80_16835	COG4112	unkown
I6G80_16840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G80_16845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G80_16850	COG1780	Probably involved in ribonucleotide reductase function
I6G80_16860	COG1923	regulation of RNA biosynthetic process
I6G80_16865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G80_16880	COG2076	Multidrug Resistance protein
I6G80_16885	COG2076	Multidrug Resistance protein
I6G80_16890	COG1764	response to oxidative stress
I6G80_16900	COG0702	epimerase
I6G80_16905	COG3631	Ketosteroid isomerase-related protein
I6G80_16910	COG1309	transcriptional regulator
I6G80_16915	COG3858	chitin binding
I6G80_16915	COG1388	LysM domain
I6G80_16925	COG5577	PFAM Coat F domain
I6G80_16930	COG0531	amino acid
I6G80_16935	COG1819	glycosyl
I6G80_16940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G80_16945	COG0398	Pfam SNARE associated Golgi protein
I6G80_16950	COG0393	Putative heavy-metal-binding
I6G80_16970	COG3263	regulation of cellular component size
I6G80_16975	COG3619	membrane
I6G80_16980	COG1231	oxidoreductase activity
I6G80_16995	COG1247	-acetyltransferase
I6G80_17005	COG0523	cobalamin synthesis protein
I6G80_17020	COG5444	nuclease activity
I6G80_17025	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6G80_17030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G80_17035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G80_17045	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6G80_17050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G80_17055	COG0156	8-amino-7-oxononanoate synthase activity
I6G80_17060	COG1063	alcohol dehydrogenase
I6G80_17070	COG2359	stage V sporulation protein S
I6G80_17075	COG1692	metallophosphoesterase
I6G80_17080	COG1418	mRNA catabolic process
I6G80_17090	COG1546	Belongs to the CinA family
I6G80_17090	COG1058	Belongs to the CinA family
I6G80_17095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G80_17100	COG1426	Protein conserved in bacteria
I6G80_17115	COG0300	oxidoreductase activity
I6G80_17120	COG0612	Peptidase, M16
I6G80_17125	COG0612	Peptidase, M16
I6G80_17130	COG2814	Major facilitator Superfamily
I6G80_17135	COG2188	Transcriptional regulator
I6G80_17140	COG1674	ftsk spoiiie
I6G80_17140	COG4980	gas vesicle protein
I6G80_17150	COG0740	serine-type endopeptidase activity
I6G80_17155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G80_17165	COG0527	aspartate kinase activity
I6G80_17170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G80_17175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G80_17180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G80_17185	COG1873	PFAM PRC-barrel domain
I6G80_17190	COG0612	Peptidase, M16
I6G80_17195	COG0726	polysaccharide deacetylase
I6G80_17200	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G80_17205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G80_17210	COG0196	riboflavin kinase activity
I6G80_17215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G80_17220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G80_17225	COG1550	Protein conserved in bacteria
I6G80_17230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G80_17235	COG1358	cellular component organization or biogenesis
I6G80_17240	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6G80_17245	COG0195	Participates in both transcription termination and antitermination
I6G80_17250	COG0779	Required for maturation of 30S ribosomal subunits
I6G80_17275	COG2176	DNA-directed DNA polymerase activity
I6G80_17280	COG0442	prolyl-tRNA aminoacylation
I6G80_17285	COG0750	zinc metalloprotease
I6G80_17290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6G80_17295	COG4589	Belongs to the CDS family
I6G80_17300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G80_17305	COG0233	cytoplasmic translational termination
I6G80_17310	COG0528	UMP kinase activity
I6G80_17315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G80_17320	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G80_17330	COG1191	sigma factor activity
I6G80_17335	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6G80_17340	COG1776	CheC inhibitor of MCP methylation
I6G80_17345	COG0835	chemotaxis
I6G80_17350	COG2198	Histidine kinase
I6G80_17350	COG0643	Histidine kinase
I6G80_17355	COG2201	protein-glutamate methylesterase activity
I6G80_17360	COG0455	bacterial-type flagellum organization
I6G80_17365	COG1419	protein localization to endoplasmic reticulum
I6G80_17370	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G80_17375	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G80_17380	COG1684	flagellar biosynthetic protein fliR
I6G80_17385	COG1987	bacterial-type flagellum assembly
I6G80_17390	COG1338	Plays a role in the flagellum-specific transport system
I6G80_17395	COG3190	flagellar
I6G80_17400	COG2201	protein-glutamate methylesterase activity
I6G80_17405	COG1776	CheC inhibitor of MCP methylation
I6G80_17405	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G80_17410	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G80_17415	COG1580	Controls the rotational direction of flagella during chemotaxis
I6G80_17420	COG1582	Flagellar protein (FlbD)
I6G80_17425	COG4786	Flagellar basal body rod
I6G80_17430	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6G80_17435	COG3144	bacterial-type flagellum assembly
I6G80_17445	COG2882	bacterial-type flagellum organization
I6G80_17450	COG1157	protein secretion by the type III secretion system
I6G80_17455	COG1317	bacterial-type flagellum organization
I6G80_17460	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G80_17465	COG1766	The M ring may be actively involved in energy transduction
I6G80_17470	COG1677	Flagellar hook-basal body complex protein FliE
I6G80_17475	COG1558	bacterial-type flagellum-dependent cell motility
I6G80_17480	COG1815	bacterial-type flagellum-dependent cell motility
I6G80_17485	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6G80_17490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6G80_17495	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6G80_17500	COG4974	Belongs to the 'phage' integrase family
I6G80_17505	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6G80_17510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G80_17515	COG0758	DNA mediated transformation
I6G80_17520	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G80_17525	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G80_17530	COG2257	FlhB HrpN YscU SpaS Family
I6G80_17540	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G80_17545	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G80_17550	COG0335	large ribosomal subunit rRNA binding
I6G80_17555	COG0336	Belongs to the RNA methyltransferase TrmD family
I6G80_17560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G80_17570	COG1837	Belongs to the UPF0109 family
I6G80_17575	COG0228	four-way junction DNA binding
I6G80_17580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G80_17585	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6G80_17590	COG0552	protein localization to endoplasmic reticulum
I6G80_17595	COG1196	nuclear chromosome segregation
I6G80_17600	COG0571	ribonuclease III activity
I6G80_17605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G80_17610	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_17615	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G80_17620	COG0416	fatty acid biosynthetic process
I6G80_17625	COG1349	DNA-binding transcription factor activity
I6G80_17630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G80_17635	COG1760	l-serine dehydratase
I6G80_17640	COG1760	l-serine dehydratase
I6G80_17645	COG1461	Dihydroxyacetone kinase
I6G80_17650	COG1302	Protein conserved in bacteria
I6G80_17655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G80_17665	COG1564	THIamine pyrophosphokinase
I6G80_17670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G80_17675	COG1162	GTPase activity
I6G80_17680	COG2815	serine threonine protein kinase
I6G80_17680	COG0515	serine threonine protein kinase
I6G80_17685	COG0631	protein serine/threonine phosphatase activity
I6G80_17690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G80_17695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G80_17695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G80_17700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G80_17705	COG0242	peptide deformylase activity
I6G80_17710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G80_17715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G80_17720	COG1758	RNA polymerase activity
I6G80_17725	COG0194	GDP metabolic process
I6G80_17730	COG2052	Domain of unknown function (DUF370)
I6G80_17735	COG1561	YicC-like family, N-terminal region
I6G80_17740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G80_17750	COG1648	precorrin-2 dehydrogenase activity
I6G80_17755	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I6G80_17760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G80_17765	COG0529	Catalyzes the synthesis of activated sulfate
I6G80_17770	COG2046	Belongs to the sulfate adenylyltransferase family
I6G80_17775	COG0306	phosphate transporter
I6G80_17780	COG0175	sulfate reduction
I6G80_17790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G80_17795	COG0284	orotidine-5'-phosphate decarboxylase activity
I6G80_17800	COG0167	dihydroorotate dehydrogenase activity
I6G80_17805	COG0543	2 iron, 2 sulfur cluster binding
I6G80_17810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G80_17815	COG0505	Belongs to the CarA family
I6G80_17820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G80_17825	COG0540	Belongs to the ATCase OTCase family
I6G80_17830	COG2233	PERMEase
I6G80_17835	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6G80_17840	COG0564	pseudouridine synthase activity
I6G80_17845	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G80_17855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G80_17860	COG3599	regulation of cell shape
I6G80_17865	COG2302	S4 RNA-binding domain
I6G80_17870	COG0762	integral membrane protein
I6G80_17875	COG1799	cell septum assembly
I6G80_17880	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G80_17885	COG1496	oxidoreductase activity
I6G80_17890	COG1873	PFAM PRC-barrel domain
I6G80_17895	COG0500	methyltransferase
I6G80_17900	COG1119	ATPase activity
I6G80_17905	COG1191	sigma factor activity
I6G80_17910	COG1191	sigma factor activity
I6G80_17920	COG4412	M6 family metalloprotease domain protein
I6G80_17920	COG1404	Belongs to the peptidase S8 family
I6G80_17925	COG4412	M6 family metalloprotease domain protein
I6G80_17925	COG1404	Belongs to the peptidase S8 family
I6G80_17930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G80_17935	COG0849	cell division
I6G80_17940	COG3856	small basic protein
I6G80_17945	COG3879	Bacterial protein of unknown function (DUF881)
I6G80_17950	COG3879	Bacterial protein of unknown function (DUF881)
I6G80_17955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G80_17960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G80_17965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G80_17970	COG0772	Belongs to the SEDS family
I6G80_17975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G80_17980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G80_17985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G80_17990	COG0768	penicillin binding
I6G80_17995	COG0768	penicillin binding
I6G80_18000	COG4839	cell division protein FtsL
I6G80_18005	COG0275	rRNA processing
I6G80_18010	COG2001	Belongs to the MraZ family
I6G80_18015	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I6G80_18020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G80_18025	COG0454	-acetyltransferase
I6G80_18035	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G80_18040	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G80_18045	COG1323	Belongs to the UPF0348 family
I6G80_18050	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6G80_18055	COG3314	Sporulation integral membrane protein YlbJ
I6G80_18060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G80_18065	COG0742	ribosomal rna small subunit methyltransferase
I6G80_18070	COG4471	UPF0298 protein
I6G80_18075	COG3679	Belongs to the UPF0342 family
I6G80_18090	COG2340	Cysteine-rich secretory protein family
I6G80_18095	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6G80_18105	COG3336	cytochrome c oxidase
I6G80_18110	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G80_18115	COG1845	cytochrome c oxidase, subunit III
I6G80_18120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G80_18125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G80_18125	COG2010	Cytochrome c
I6G80_18130	COG0109	protoheme IX farnesyltransferase activity
I6G80_18135	COG1612	heme a metabolic process
I6G80_18140	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6G80_18145	COG0772	Belongs to the SEDS family
I6G80_18150	COG4838	Belongs to the UPF0358 family
I6G80_18155	COG2066	Belongs to the glutaminase family
I6G80_18160	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G80_18165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6G80_18175	COG4896	Protein conserved in bacteria
I6G80_18180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G80_18185	COG1846	Transcriptional regulator
I6G80_18195	COG1217	gtp-binding protein TYPA
I6G80_18210	COG1595	DNA-templated transcription, initiation
I6G80_18225	COG0483	inositol monophosphate 1-phosphatase activity
I6G80_18235	COG4493	Belongs to the UPF0637 family
I6G80_18240	COG4476	Belongs to the UPF0223 family
I6G80_18245	COG1982	Orn Lys Arg decarboxylase major
I6G80_18255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G80_18260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G80_18265	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G80_18270	COG0022	dehydrogenase e1 component
I6G80_18275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G80_18280	COG0497	DNA recombination
I6G80_18290	COG0242	peptide deformylase activity
I6G80_18300	COG0561	phosphatase activity
I6G80_18305	COG5503	Protein of unknown function (DUF1447)
I6G80_18310	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G80_18315	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6G80_18320	COG0569	domain protein
I6G80_18325	COG3852	Histidine kinase
I6G80_18330	COG2002	toxin-antitoxin pair type II binding
I6G80_18335	COG1077	Cell shape determining protein MreB Mrl
I6G80_18345	COG2309	aminopeptidase activity
I6G80_18355	COG0488	(ABC) transporter
I6G80_18375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G80_18375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G80_18375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G80_18380	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G80_18385	COG1349	DNA-binding transcription factor activity
I6G80_18390	COG0577	efflux transmembrane transporter activity
I6G80_18395	COG1136	(ABC) transporter
I6G80_18400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G80_18410	COG1132	(ABC) transporter
I6G80_18415	COG1132	(ABC) transporter
I6G80_18425	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G80_18430	COG0314	molybdopterin synthase activity
I6G80_18435	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6G80_18440	COG0303	'Molybdopterin
I6G80_18445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G80_18450	COG0746	molybdenum cofactor guanylyltransferase activity
I6G80_18465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G80_18470	COG0450	alkyl hydroperoxide reductase
I6G80_18480	COG1473	amidohydrolase
I6G80_18485	COG2171	N-acyltransferase activity
I6G80_18490	COG0716	FMN binding
I6G80_18500	COG0716	FMN binding
I6G80_18505	COG0583	DNA-binding transcription factor activity
I6G80_18510	COG0517	IMP dehydrogenase activity
I6G80_18520	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I6G80_18530	COG4703	Protein of unknown function (DUF1797)
I6G80_18540	COG2200	EAL domain
I6G80_18545	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_18550	COG1408	metallophosphoesterase
I6G80_18555	COG1376	ErfK ybiS ycfS ynhG family protein
I6G80_18560	COG2814	Major facilitator Superfamily
I6G80_18570	COG0784	Response regulator, receiver
I6G80_18570	COG0835	chemotaxis
I6G80_18580	COG1714	RDD family
I6G80_18590	COG0436	Aminotransferase
I6G80_18595	COG4191	Histidine kinase
I6G80_18600	COG0768	penicillin binding
I6G80_18605	COG2340	Cysteine-rich secretory protein family
I6G80_18610	COG2084	Dehydrogenase
I6G80_18615	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_18620	COG0840	transmembrane signaling receptor activity
I6G80_18625	COG0456	acetyltransferase
I6G80_18630	COG1533	DNA photolyase activity
I6G80_18640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G80_18645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G80_18650	COG1263	PTS System
I6G80_18650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_18650	COG2190	(PTS) system
I6G80_18655	COG3711	transcriptional antiterminator
I6G80_18660	COG1609	Transcriptional regulator
I6G80_18670	COG0006	proline dipeptidase activity
I6G80_18675	COG2217	Heavy metal translocating P-type atpase
I6G80_18680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G80_18685	COG2244	polysaccharide biosynthetic process
I6G80_18690	COG3773	Cell wall hydrolase
I6G80_18700	COG4873	Protein conserved in bacteria
I6G80_18735	COG3655	Transcriptional regulator
I6G80_18740	COG3739	integral membrane protein
I6G80_18755	COG0582	viral genome integration into host DNA
I6G80_18785	COG1388	LysM domain
I6G80_18785	COG3409	Peptidoglycan-binding domain 1 protein
I6G80_18785	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6G80_18795	COG0584	glycerophosphoryl diester phosphodiesterase
I6G80_18830	COG3953	SLT domain
I6G80_18830	COG5280	Phage tail tape measure protein TP901
I6G80_18880	COG0740	serine-type endopeptidase activity
I6G80_18965	COG1793	dna ligase
I6G80_19020	COG3584	3D domain protein
I6G80_19025	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6G80_19035	COG0756	dUTP diphosphatase activity
I6G80_19040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G80_19050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G80_19055	COG1780	Probably involved in ribonucleotide reductase function
I6G80_19090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G80_19090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G80_19205	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G80_19210	COG0602	queuosine metabolic process
I6G80_19215	COG0720	synthase
I6G80_19220	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6G80_19225	COG3949	Membrane
I6G80_19230	COG0542	response to heat
I6G80_19235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G80_19240	COG1360	Flagellar Motor Protein
I6G80_19245	COG1846	Transcriptional regulator
I6G80_19250	COG3852	Histidine kinase
I6G80_19260	COG3339	Conserved Protein
I6G80_19265	COG0346	lactoylglutathione lyase activity
I6G80_19270	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6G80_19275	COG0235	Class ii aldolase
I6G80_19275	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
I6G80_19280	COG1850	ribulose-bisphosphate carboxylase activity
I6G80_19285	COG0436	Aminotransferase
I6G80_19290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G80_19295	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I6G80_19300	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6G80_19305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G80_19310	COG5002	protein histidine kinase activity
I6G80_19315	COG3594	Acyltransferase
I6G80_19330	COG0768	penicillin binding
I6G80_19335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G80_19340	COG0501	Belongs to the peptidase M48B family
I6G80_19360	COG1191	sigma factor activity
I6G80_19365	COG0861	Integral membrane protein TerC family
I6G80_19370	COG0586	Pfam SNARE associated Golgi protein
I6G80_19375	COG3300	MHYT domain
I6G80_19375	COG5001	Diguanylate cyclase
I6G80_19380	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6G80_19385	COG1793	dna ligase
I6G80_19385	COG3285	dna ligase
I6G80_19390	COG1846	Transcriptional regulator
I6G80_19405	COG0789	Transcriptional regulator
I6G80_19420	COG5444	nuclease activity
I6G80_19555	COG1783	phage Terminase large subunit
I6G80_19560	COG3728	DNA packaging
I6G80_19560	COG5484	DNA packaging
I6G80_19630	COG0629	single-stranded DNA binding
I6G80_19645	COG3331	DNA recombination
I6G80_19685	COG1484	DNA-dependent DNA replication
I6G80_19735	COG3645	SOS response
I6G80_19735	COG3646	Phage regulatory protein
I6G80_19750	COG3620	sequence-specific DNA binding
I6G80_19765	COG2856	Zn peptidase
I6G80_19770	COG0582	viral genome integration into host DNA
I6G80_19780	COG2239	Acts as a magnesium transporter
I6G80_19790	COG1404	Belongs to the peptidase S8 family
I6G80_19795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G80_19810	COG0406	alpha-ribazole phosphatase activity
I6G80_19815	COG0590	tRNA wobble adenosine to inosine editing
I6G80_19825	COG1764	response to oxidative stress
I6G80_19830	COG1846	Transcriptional regulator
I6G80_19835	COG1764	response to oxidative stress
I6G80_19840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G80_19845	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G80_19850	COG0788	formyltetrahydrofolate deformylase activity
I6G80_19855	COG2076	Multidrug Resistance protein
I6G80_19860	COG2076	Multidrug Resistance protein
I6G80_19865	COG2318	DinB family
I6G80_19885	COG3866	Pectate lyase
I6G80_19895	COG1607	acyl-coa hydrolase
I6G80_19900	COG1834	amidinotransferase
I6G80_19905	COG4608	Belongs to the ABC transporter superfamily
I6G80_19910	COG0791	NLP P60 protein
I6G80_19920	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G80_19925	COG4166	transmembrane transport
I6G80_19930	COG0444	Belongs to the ABC transporter superfamily
I6G80_19935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G80_19940	COG0601	transmembrane transport
I6G80_19945	COG2362	D-Aminopeptidase
I6G80_19950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G80_19955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G80_19965	COG0346	lactoylglutathione lyase activity
I6G80_19970	COG0531	amino acid
I6G80_19975	COG0395	ABC-type sugar transport system, permease component
I6G80_19980	COG4209	transmembrane transport
I6G80_19985	COG1653	transport
I6G80_19995	COG1874	Beta-galactosidase
I6G80_20000	COG2755	lipolytic protein G-D-S-L family
I6G80_20005	COG0667	Aldo Keto reductase
I6G80_20010	COG3401	FG-GAP repeat protein
I6G80_20015	COG2755	lipolytic protein G-D-S-L family
I6G80_20025	COG3401	FG-GAP repeat protein
I6G80_20030	COG5578	integral membrane protein
I6G80_20040	COG2755	lipolytic protein G-D-S-L family
I6G80_20045	COG2207	Transcriptional regulator
I6G80_20050	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6G80_20055	COG0395	ABC-type sugar transport system, permease component
I6G80_20060	COG1175	transmembrane transport
I6G80_20065	COG1653	transport
I6G80_20070	COG4753	response regulator
I6G80_20070	COG2207	Transcriptional regulator
I6G80_20075	COG2972	Histidine kinase
I6G80_20080	COG5578	integral membrane protein
I6G80_20085	COG0405	Gamma-glutamyltransferase
I6G80_20090	COG1392	Phosphate transport regulator
I6G80_20095	COG0306	phosphate transporter
I6G80_20110	COG2271	Major facilitator Superfamily
I6G80_20115	COG1063	alcohol dehydrogenase
I6G80_20120	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_20125	COG1312	Catalyzes the dehydration of D-mannonate
I6G80_20130	COG1063	alcohol dehydrogenase
I6G80_20135	COG1802	Transcriptional regulator
I6G80_20170	COG3778	Protein conserved in bacteria
I6G80_20175	COG3299	homolog of phage Mu protein gp47
I6G80_20180	COG3628	GPW Gp25 family protein
I6G80_20190	COG4193	domain, Protein
I6G80_20195	COG1652	LysM domain
I6G80_20200	COG3953	SLT domain
I6G80_20200	COG5412	phage tail tape measure protein
I6G80_20250	COG4653	Phage capsid family
I6G80_20255	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6G80_20260	COG5518	Phage portal protein
I6G80_20265	COG1783	phage Terminase large subunit
I6G80_20270	COG3728	DNA packaging
I6G80_20270	COG5484	DNA packaging
I6G80_20275	COG1595	DNA-templated transcription, initiation
I6G80_20295	COG1484	DNA-dependent DNA replication
I6G80_20300	COG1522	sequence-specific DNA binding
I6G80_20315	COG1396	sequence-specific DNA binding
I6G80_20320	COG2856	Zn peptidase
I6G80_20325	COG4195	phage-related replication protein
I6G80_20330	COG5444	nuclease activity
I6G80_20350	COG1309	transcriptional regulator
I6G80_20355	COG2814	Major facilitator Superfamily
I6G80_20360	COG3584	3D domain protein
I6G80_20360	COG1388	LysM domain
I6G80_20370	COG0346	lactoylglutathione lyase activity
I6G80_20375	COG0697	spore germination
I6G80_20380	COG0583	DNA-binding transcription factor activity
I6G80_20390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G80_20395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G80_20400	COG0583	DNA-binding transcription factor activity
I6G80_20410	COG0110	maltose O-acetyltransferase activity
I6G80_20425	COG3507	Belongs to the glycosyl hydrolase 43 family
I6G80_20430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G80_20445	COG5505	Protein of unknown function (DUF819)
I6G80_20450	COG0626	cystathionine gamma-synthase activity
I6G80_20455	COG0626	cystathionine gamma-synthase activity
I6G80_20470	COG2382	esterase
I6G80_20475	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6G80_20480	COG2153	protein acetylation
I6G80_20485	COG2246	polysaccharide biosynthetic process
I6G80_20490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G80_20495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G80_20500	COG0586	Pfam SNARE associated Golgi protein
I6G80_20510	COG0210	DNA helicase
I6G80_20565	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6G80_20570	COG0351	phosphomethylpyrimidine kinase
I6G80_20575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G80_20580	COG2022	thiamine diphosphate biosynthetic process
I6G80_20585	COG2104	thiamine diphosphate biosynthetic process
I6G80_20595	COG0352	thiamine-phosphate diphosphorylase activity
I6G80_20600	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G80_20605	COG0475	glutathione-regulated potassium exporter activity
I6G80_20605	COG0569	domain protein
I6G80_20610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G80_20615	COG0564	pseudouridine synthase activity
I6G80_20620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G80_20625	COG2357	RelA SpoT domain protein
I6G80_20635	COG4116	CYTH
I6G80_20640	COG0741	lytic transglycosylase activity
I6G80_20645	COG2346	COG2346, Truncated hemoglobins
I6G80_20650	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G80_20655	COG1164	Oligoendopeptidase f
I6G80_20660	COG4469	Competence protein
I6G80_20665	COG3290	protein histidine kinase activity
I6G80_20670	COG4565	transcriptional regulatory protein
I6G80_20690	COG4862	establishment of competence for transformation
I6G80_20700	COG0861	Integral membrane protein TerC family
I6G80_20705	COG1393	Belongs to the ArsC family
I6G80_20710	COG0456	acetyltransferase
I6G80_20715	COG4608	Belongs to the ABC transporter superfamily
I6G80_20720	COG0444	Belongs to the ABC transporter superfamily
I6G80_20725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G80_20730	COG0601	transmembrane transport
I6G80_20735	COG4166	transmembrane transport
I6G80_20740	COG0180	Tryptophanyl-tRNA synthetase
I6G80_20765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G80_20770	COG0601	transmembrane transport
I6G80_20780	COG4608	Belongs to the ABC transporter superfamily
I6G80_20785	COG0444	Belongs to the ABC transporter superfamily
I6G80_20790	COG5504	Zn-dependent protease
I6G80_20795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G80_20800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G80_20815	COG1744	ABC transporter substrate-binding protein PnrA-like
I6G80_20825	COG2267	carboxylic ester hydrolase activity
I6G80_20840	COG1968	undecaprenyl-diphosphatase activity
I6G80_20845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G80_20850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G80_20855	COG0505	Belongs to the CarA family
I6G80_20860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G80_20865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G80_20870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6G80_20875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G80_20880	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G80_20885	COG1073	alpha beta
I6G80_20890	COG0561	phosphatase activity
I6G80_20905	COG0516	GMP reductase activity
I6G80_20915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G80_20920	COG1307	EDD domain protein, DegV family
I6G80_20935	COG2996	Protein conserved in bacteria
I6G80_20940	COG1666	GTP binding
I6G80_20945	COG0646	methionine synthase
I6G80_20945	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G80_20950	COG1410	methionine synthase
I6G80_20950	COG0646	methionine synthase
I6G80_20955	COG2378	regulation of single-species biofilm formation
I6G80_20960	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_20965	COG2153	protein acetylation
I6G80_20990	COG0076	glutamate decarboxylase activity
I6G80_21000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G80_21005	COG0673	inositol 2-dehydrogenase activity
I6G80_21010	COG1609	Transcriptional regulator
I6G80_21020	COG2207	Transcriptional regulator
I6G80_21020	COG1917	Cupin 2, conserved barrel domain protein
I6G80_21025	COG0534	Mate efflux family protein
I6G80_21040	COG0367	asparagine synthase
I6G80_21060	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G80_21070	COG5337	Spore coat protein CotH
I6G80_21115	COG0419	ATPase involved in DNA repair
I6G80_21120	COG0420	3'-5' exonuclease activity
I6G80_21125	COG1074	ATP-dependent DNA helicase activity
I6G80_21130	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6G80_21135	COG4149	molybdate abc transporter
I6G80_21140	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G80_21145	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I6G80_21150	COG0745	RESPONSE REGULATOR receiver
I6G80_21155	COG5002	protein histidine kinase activity
I6G80_21165	COG2814	Major facilitator Superfamily
I6G80_21165	COG0477	Major facilitator Superfamily
I6G80_21170	COG0318	PFAM AMP-dependent synthetase and ligase
I6G80_21175	COG3546	catalase activity
I6G80_21190	COG3180	Ammonia monooxygenase
I6G80_21195	COG1486	melibiose metabolic process
I6G80_21200	COG0395	ABC-type sugar transport system, permease component
I6G80_21205	COG1175	transmembrane transport
I6G80_21210	COG1653	transport
I6G80_21215	COG1609	Transcriptional regulator
I6G80_21235	COG0457	Tetratricopeptide repeat
I6G80_21245	COG2814	Major facilitator Superfamily
I6G80_21250	COG0549	Belongs to the carbamate kinase family
I6G80_21260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G80_21265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G80_21270	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G80_21275	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G80_21280	COG3257	ureidoglycine aminohydrolase activity
I6G80_21285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G80_21290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G80_21295	COG2508	Transcriptional regulator
I6G80_21305	COG1404	Belongs to the peptidase S8 family
I6G80_21310	COG0681	Belongs to the peptidase S26 family
I6G80_21315	COG0398	Pfam SNARE associated Golgi protein
I6G80_21325	COG4903	ComK protein
I6G80_21335	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_21340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G80_21340	COG0723	plastoquinol--plastocyanin reductase activity
I6G80_21345	COG0840	transmembrane signaling receptor activity
I6G80_21350	COG0406	alpha-ribazole phosphatase activity
I6G80_21355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G80_21360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G80_21365	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6G80_21370	COG0697	spore germination
I6G80_21380	COG0501	Belongs to the peptidase M48B family
I6G80_21395	COG1396	sequence-specific DNA binding
I6G80_21405	COG0318	PFAM AMP-dependent synthetase and ligase
I6G80_21410	COG0095	Lipoate-protein ligase
I6G80_21415	COG1234	tRNA 3'-trailer cleavage
I6G80_21425	COG1301	dicarboxylic acid transport
I6G80_21435	COG1363	Peptidase, m42
I6G80_21440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G80_21445	COG1511	domain protein
I6G80_21450	COG1309	transcriptional regulator
I6G80_21455	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6G80_21460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G80_21465	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6G80_21470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G80_21475	COG2329	Antibiotic biosynthesis monooxygenase
I6G80_21480	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G80_21485	COG1473	amidohydrolase
I6G80_21495	COG4473	ABC transporter
I6G80_21500	COG1131	(ABC) transporter
I6G80_21505	COG0537	adenosine 5'-monophosphoramidase activity
I6G80_21510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6G80_21525	COG4980	gas vesicle protein
I6G80_21530	COG1846	Transcriptional regulator
I6G80_21560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G80_21570	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6G80_21580	COG0420	3'-5' exonuclease activity
I6G80_21585	COG1668	transmembrane transport
I6G80_21590	COG4152	abc transporter atp-binding protein
I6G80_21610	COG0457	Tetratricopeptide repeat
I6G80_21615	COG1024	Enoyl-CoA hydratase
I6G80_21630	COG0475	glutathione-regulated potassium exporter activity
I6G80_21635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G80_21640	COG0561	phosphatase activity
I6G80_21645	COG3679	Belongs to the UPF0342 family
I6G80_21650	COG4399	Belongs to the UPF0754 family
I6G80_21655	COG0189	ligase activity
I6G80_21660	COG0189	ligase activity
I6G80_21670	COG2508	Transcriptional regulator
I6G80_21675	COG3842	ATPase activity
I6G80_21695	COG0702	epimerase
I6G80_21700	COG1132	(ABC) transporter
I6G80_21705	COG1132	(ABC) transporter
I6G80_21710	COG0589	response to stress
I6G80_21735	COG2017	converts alpha-aldose to the beta-anomer
I6G80_21740	COG1757	Na H antiporter
I6G80_21750	COG0726	polysaccharide deacetylase
I6G80_21760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G80_21765	COG0668	transmembrane transport
I6G80_21775	COG0584	glycerophosphoryl diester phosphodiesterase
I6G80_21780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G80_21785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G80_21805	COG1253	flavin adenine dinucleotide binding
I6G80_21810	COG0789	Transcriptional regulator
I6G80_21815	COG1253	flavin adenine dinucleotide binding
I6G80_21820	COG1309	transcriptional regulator
I6G80_21830	COG3152	Membrane
I6G80_21835	COG0204	Acyl-transferase
I6G80_21840	COG0662	Cupin 2, conserved barrel domain protein
I6G80_21845	COG1595	DNA-templated transcription, initiation
I6G80_21865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G80_21870	COG2207	Transcriptional regulator
I6G80_21870	COG3708	Transcriptional regulator
I6G80_21880	COG0733	neurotransmitter:sodium symporter activity
I6G80_21885	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_21890	COG2133	pyrroloquinoline quinone binding
I6G80_21895	COG0372	Belongs to the citrate synthase family
I6G80_21900	COG0583	DNA-binding transcription factor activity
I6G80_21905	COG1388	LysM domain
I6G80_21905	COG0791	NLP P60 protein
I6G80_21910	COG2719	SpoVR family
I6G80_21915	COG1017	nitric oxide dioxygenase activity
I6G80_21915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G80_21920	COG1959	2 iron, 2 sulfur cluster binding
I6G80_21935	COG0431	NADPH-dependent FMN reductase
I6G80_21940	COG2197	response regulator
I6G80_21945	COG4585	Histidine kinase
I6G80_21945	COG2203	Gaf domain
I6G80_21960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G80_21965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G80_21970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G80_21975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G80_21980	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6G80_21985	COG0604	alcohol dehydrogenase
I6G80_21990	COG0679	Auxin Efflux Carrier
I6G80_21995	COG2116	formate transmembrane transporter activity
I6G80_22000	COG0488	(ABC) transporter
I6G80_22005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G80_22005	COG3153	acetyltransferase
I6G80_22010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G80_22015	COG0517	IMP dehydrogenase activity
I6G80_22025	COG0564	pseudouridine synthase activity
I6G80_22030	COG3764	Sortase (surface protein transpeptidase)
I6G80_22035	COG4085	toxin activity
I6G80_22035	COG1525	nuclease
I6G80_22035	COG0737	Belongs to the 5'-nucleotidase family
I6G80_22040	COG5002	protein histidine kinase activity
I6G80_22045	COG5577	PFAM Coat F domain
I6G80_22070	COG1823	symporter activity
I6G80_22075	COG1464	Belongs to the NlpA lipoprotein family
I6G80_22080	COG2011	ABC-type metal ion transport system permease component
I6G80_22085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G80_22090	COG1278	Cold shock
I6G80_22095	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G80_22100	COG1131	(ABC) transporter
I6G80_22105	COG1131	(ABC) transporter
I6G80_22115	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6G80_22120	COG2814	Major facilitator Superfamily
I6G80_22125	COG1566	PFAM secretion protein HlyD family protein
I6G80_22135	COG2718	Belongs to the UPF0229 family
I6G80_22140	COG2766	serine protein kinase
I6G80_22150	COG1664	Polymer-forming cytoskeletal
I6G80_22155	COG0789	Transcriptional regulator
I6G80_22160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G80_22170	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G80_22175	COG3382	B3 4 domain protein
I6G80_22185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G80_22205	COG1131	(ABC) transporter
I6G80_22215	COG1476	TRANSCRIPTIONal
I6G80_22225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G80_22230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G80_22235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G80_22240	COG1116	anion transmembrane transporter activity
I6G80_22245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6G80_22250	COG0710	3-dehydroquinate dehydratase activity
I6G80_22260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G80_22385	COG0582	viral genome integration into host DNA
I6G80_22395	COG4974	Belongs to the 'phage' integrase family
I6G80_22505	COG0735	belongs to the Fur family
I6G80_22510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G80_22515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G80_22520	COG4129	membrane
I6G80_22525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G80_22530	COG0601	transmembrane transport
I6G80_22535	COG0747	negative chemotaxis
I6G80_22540	COG4608	Belongs to the ABC transporter superfamily
I6G80_22545	COG0444	Belongs to the ABC transporter superfamily
I6G80_22550	COG1132	(ABC) transporter
I6G80_22555	COG3557	Belongs to the UPF0374 family
I6G80_22570	COG1028	Short-chain dehydrogenase reductase Sdr
I6G80_22580	COG1194	a g-specific adenine glycosylase
I6G80_22585	COG1988	membrane-bound metal-dependent
I6G80_22590	COG4485	Bacterial membrane protein, YfhO
I6G80_22600	COG0463	Glycosyl transferase, family 2
I6G80_22630	COG2137	regulation of response to DNA damage stimulus
I6G80_22635	COG1090	epimerase
I6G80_22655	COG0778	Nitroreductase
I6G80_22660	COG0384	phenazine biosynthesis protein PhzF
I6G80_22665	COG0392	lysyltransferase activity
I6G80_22665	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6G80_22675	COG1051	belongs to the nudix hydrolase family
I6G80_22680	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G80_22685	COG1653	transport
I6G80_22690	COG2207	Transcriptional regulator
I6G80_22690	COG1917	Cupin 2, conserved barrel domain protein
I6G80_22695	COG3507	Belongs to the glycosyl hydrolase 43 family
I6G80_22705	COG2514	catechol 2,3-dioxygenase activity
I6G80_22710	COG2259	Doxx family
I6G80_22715	COG1733	regulation of RNA biosynthetic process
I6G80_22730	COG1263	PTS System
I6G80_22730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_22735	COG1737	Transcriptional regulator
I6G80_22740	COG1486	melibiose metabolic process
I6G80_22745	COG1742	UPF0060 membrane protein
I6G80_22750	COG3284	Transcriptional regulator
I6G80_22755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G80_22760	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G80_22765	COG0022	dehydrogenase e1 component
I6G80_22770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G80_22780	COG5609	conserved protein (DUF2294)
I6G80_22785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G80_22790	COG3002	Belongs to the UPF0753 family
I6G80_22795	COG0288	reversible hydration of carbon dioxide
I6G80_22800	COG3711	transcriptional antiterminator
I6G80_22805	COG1263	PTS System
I6G80_22805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_22810	COG0477	Major facilitator Superfamily
I6G80_22820	COG1819	glycosyl
I6G80_22845	COG4637	Psort location Cytoplasmic, score
I6G80_22850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G80_22855	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6G80_22860	COG0598	Magnesium transport protein CorA
I6G80_22870	COG0371	Dehydrogenase
I6G80_22875	COG0726	polysaccharide deacetylase
I6G80_22885	COG0535	radical SAM domain protein
I6G80_22895	COG0387	Pfam Sodium calcium exchanger
I6G80_22905	COG0477	Major facilitator Superfamily
I6G80_22910	COG1295	ribonuclease BN
I6G80_22915	COG4980	gas vesicle protein
I6G80_22920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G80_22925	COG1115	amino acid carrier protein
I6G80_22930	COG4840	Belongs to the UPF0435 family
I6G80_22935	COG0693	protein deglycase activity
I6G80_22945	COG0778	Nitroreductase
I6G80_22950	COG1733	regulation of RNA biosynthetic process
I6G80_22955	COG0657	acetylesterase activity
I6G80_22965	COG0673	inositol 2-dehydrogenase activity
I6G80_22975	COG0463	Glycosyl transferase, family 2
I6G80_22975	COG0457	Tetratricopeptide repeat
I6G80_22980	COG1215	transferase activity, transferring glycosyl groups
I6G80_22990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G80_22995	COG1045	serine acetyltransferase
I6G80_23000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G80_23025	COG2188	Transcriptional regulator
I6G80_23030	COG0366	Alpha amylase catalytic
I6G80_23035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_23035	COG1263	PTS System
I6G80_23040	COG1115	amino acid carrier protein
I6G80_23050	COG1368	sulfuric ester hydrolase activity
I6G80_23055	COG0024	Methionine aminopeptidase
I6G80_23070	COG2258	MOSC domain
I6G80_23075	COG1254	Belongs to the acylphosphatase family
I6G80_23080	COG0640	Transcriptional regulator
I6G80_23085	COG5658	integral membrane protein
I6G80_23090	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I6G80_23100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G80_23120	COG0471	metal ion transport
I6G80_23135	COG2130	NADP-dependent
I6G80_23140	COG0513	Belongs to the DEAD box helicase family
I6G80_23145	COG0488	(ABC) transporter
I6G80_23150	COG2814	Major facilitator Superfamily
I6G80_23155	COG0789	Transcriptional regulator
I6G80_23165	COG2124	cytochrome p450
I6G80_23170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G80_23175	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6G80_23180	COG0156	8-amino-7-oxononanoate synthase activity
I6G80_23185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G80_23190	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
I6G80_23195	COG0523	cobalamin synthesis protein
I6G80_23210	COG1469	GTP cyclohydrolase I activity
I6G80_23220	COG0488	(ABC) transporter
I6G80_23225	COG0471	metal ion transport
I6G80_23230	COG0840	transmembrane signaling receptor activity
I6G80_23235	COG1012	belongs to the aldehyde dehydrogenase family
I6G80_23250	COG0217	transcriptional regulatory protein
I6G80_23265	COG0457	Tetratricopeptide repeat
I6G80_23270	COG3711	transcriptional antiterminator
I6G80_23275	COG2723	6-phospho-beta-galactosidase activity
I6G80_23280	COG1263	PTS System
I6G80_23280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G80_23280	COG2190	(PTS) system
I6G80_23290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G80_23295	COG1597	lipid kinase activity
I6G80_23300	COG1957	nucleoside hydrolase
I6G80_23305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G80_23315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G80_23320	COG1309	transcriptional regulator
I6G80_23325	COG4124	Belongs to the glycosyl hydrolase 26 family
I6G80_23340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G80_23345	COG0154	amidase activity
I6G80_23350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G80_23360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G80_23365	COG1285	pathogenesis
I6G80_23370	COG0363	glucosamine-6-phosphate deaminase activity
I6G80_23375	COG3457	Alanine racemase
I6G80_23380	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6G80_23385	COG0626	cystathionine gamma-synthase activity
I6G80_23390	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6G80_23410	COG2188	Transcriptional regulator
I6G80_23420	COG4851	CamS sex pheromone cAM373 precursor
I6G80_23425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G80_23430	COG0210	DNA helicase
I6G80_23435	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I6G80_23440	COG4496	protein, YerC YecD
I6G80_23445	COG1470	cell adhesion involved in biofilm formation
I6G80_23450	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6G80_23470	COG2124	cytochrome p450
I6G80_23485	COG0151	Belongs to the GarS family
I6G80_23490	COG0138	bifunctional purine biosynthesis protein purh
I6G80_23495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G80_23500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G80_23505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G80_23510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G80_23515	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G80_23520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G80_23525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G80_23530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G80_23535	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G80_23540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G80_23550	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6G80_23565	COG2252	PERMEase
I6G80_23570	COG0519	Catalyzes the synthesis of GMP from XMP
I6G80_23570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G80_23575	COG1305	Transglutaminase-like
I6G80_23580	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I6G80_23585	COG0714	Associated with various cellular activities
I6G80_23590	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G80_23605	COG2132	Multicopper oxidase
I6G80_23615	COG0702	epimerase
I6G80_23645	COG0823	Involved in the tonB-independent uptake of proteins
I6G80_23650	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G80_23665	COG1846	Transcriptional regulator
I6G80_23670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G80_23675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G80_23680	COG0366	Alpha amylase catalytic
I6G80_23685	COG1554	hydrolase, family 65, central catalytic
I6G80_23690	COG5521	maltodextrose utilization protein MalA
I6G80_23695	COG3833	ABC-type maltose transport systems, permease component
I6G80_23700	COG1175	transmembrane transport
I6G80_23705	COG2182	Extracellular solute-binding protein
I6G80_23710	COG0366	Alpha amylase catalytic
I6G80_23715	COG1609	Transcriptional regulator
I6G80_23725	COG0726	polysaccharide deacetylase
I6G80_23750	COG0772	Belongs to the SEDS family
I6G80_23755	COG3339	Conserved Protein
I6G80_23760	COG1280	lysine exporter protein (LysE YggA)
I6G80_23765	COG1378	Sugar-specific transcriptional regulator TrmB
I6G80_23775	COG4260	virion core protein, lumpy skin disease virus
I6G80_23780	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6G80_23785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G80_23790	COG1842	Phage shock protein A
I6G80_23795	COG2814	Major facilitator Superfamily
I6G80_23800	COG2272	Belongs to the type-B carboxylesterase lipase family
I6G80_23805	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I6G80_23810	COG3189	MarR family transcriptional regulator
I6G80_23820	COG3848	Pyruvate phosphate dikinase
I6G80_23820	COG0574	Belongs to the PEP-utilizing enzyme family
I6G80_23825	COG1309	transcriptional regulator
I6G80_23835	COG2135	peptidase activity
I6G80_23855	COG2720	vancomycin resistance protein
I6G80_23870	COG0459	protein refolding
I6G80_23875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G80_23880	COG1266	CAAX protease self-immunity
I6G80_23890	COG0805	protein transport
I6G80_23895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G80_23900	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6G80_23905	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G80_23910	COG0488	(ABC) transporter
I6G80_23915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G80_23920	COG0456	acetyltransferase
I6G80_23925	COG1214	PFAM Peptidase M22, glycoprotease
I6G80_23930	COG0802	atpase or kinase
I6G80_23935	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6G80_23975	COG2814	Major facilitator Superfamily
I6G80_23980	COG3764	Sortase (surface protein transpeptidase)
I6G80_23990	COG3279	Response regulator of the LytR AlgR family
I6G80_23995	COG0745	RESPONSE REGULATOR receiver
I6G80_23995	COG2972	Histidine kinase
I6G80_24000	COG2814	Major facilitator Superfamily
I6G80_24005	COG2755	lipolytic protein G-D-S-L family
I6G80_24005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6G80_24015	COG1595	DNA-templated transcription, initiation
I6G80_24030	COG1113	amino acid transport
I6G80_24035	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6G80_24055	COG0583	DNA-binding transcription factor activity
I6G80_24065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G80_24070	COG1733	regulation of RNA biosynthetic process
I6G80_24080	COG2808	Putative FMN-binding domain
I6G80_24085	COG0456	acetyltransferase
I6G80_24090	COG1846	Transcriptional regulator
I6G80_24095	COG2364	Membrane
I6G80_24100	COG1063	alcohol dehydrogenase
I6G80_24105	COG1278	Cold shock
I6G80_24110	COG3239	Fatty acid desaturase
I6G80_24115	COG1476	TRANSCRIPTIONal
I6G80_24160	COG3091	SprT-like family
I6G80_24170	COG2409	Drug exporters of the RND superfamily
I6G80_24170	COG1033	growth of symbiont in host cell
I6G80_24175	COG1309	transcriptional regulator
I6G80_24180	COG2183	response to ionizing radiation
I6G80_24185	COG2208	phosphoserine phosphatase activity
I6G80_24190	COG1191	sigma factor activity
I6G80_24195	COG2172	sigma factor antagonist activity
I6G80_24205	COG2208	phosphoserine phosphatase activity
I6G80_24210	COG2172	sigma factor antagonist activity
I6G80_24215	COG1366	Belongs to the anti-sigma-factor antagonist family
I6G80_24220	COG1366	Belongs to the anti-sigma-factor antagonist family
I6G80_24225	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6G80_24230	COG0864	Transcriptional regulator
I6G80_24235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G80_24240	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G80_24245	COG0705	Rhomboid family
I6G80_24250	COG3428	Bacterial PH domain
I6G80_24255	COG3402	PFAM membrane-flanked domain
I6G80_24260	COG0513	Belongs to the DEAD box helicase family
I6G80_24285	COG0433	COG0433 Predicted ATPase
I6G80_24290	COG0433	COG0433 Predicted ATPase
I6G80_24300	COG5644	endopeptidase inhibitor activity
I6G80_24305	COG0791	NLP P60 protein
I6G80_24305	COG0741	lytic transglycosylase activity
I6G80_24315	COG2002	toxin-antitoxin pair type II binding
I6G80_24320	COG0653	protein targeting
I6G80_24390	COG0433	COG0433 Predicted ATPase
I6G80_24400	COG5644	endopeptidase inhibitor activity
I6G80_24415	COG2002	toxin-antitoxin pair type II binding
I6G80_24420	COG0653	protein targeting
I6G80_24425	COG0457	Tetratricopeptide repeat
I6G80_24535	COG0433	COG0433 Predicted ATPase
I6G80_24540	COG0433	COG0433 Predicted ATPase
I6G80_24555	COG5644	endopeptidase inhibitor activity
I6G80_24565	COG0741	lytic transglycosylase activity
I6G80_24565	COG0791	NLP P60 protein
I6G80_24575	COG2002	toxin-antitoxin pair type II binding
I6G80_24580	COG0653	protein targeting
I6G80_24585	COG0457	Tetratricopeptide repeat