locus-tag class description GII88_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GII88_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GII88_00015 ENOG410848D S4 domain protein YaaA GII88_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GII88_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GII88_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GII88_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GII88_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GII88_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GII88_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GII88_00100 ENOG4105BZW Glycerate kinase GII88_00105 ENOG4107QQ0 gntp family GII88_00110 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GII88_00125 ENOG4105ZMH deoxynucleoside kinase GII88_00135 ENOG4105VRS hydrolase family 18 GII88_00140 ENOG4105GTG Isochorismatase GII88_00145 ENOG4108Z6B deaminase GII88_00155 ENOG4105C6E dna polymerase iii GII88_00160 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GII88_00165 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GII88_00175 ENOG41067KS pro-sigma K processing GII88_00215 ENOG4105CDW Resistance protein GII88_00220 ENOG4105CXN decarboxylase GII88_00225 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GII88_00230 ENOG4105X0R protein from nitrogen regulatory protein P-II GII88_00235 ENOG4105XVJ Protein of unknown function (DUF327) GII88_00240 ENOG4105FA2 dna polymerase iii GII88_00245 ENOG4105MA4 psp1 domain protein GII88_00250 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) GII88_00255 ENOG41060K3 Methyltransferase GII88_00260 ENOG4105VC4 domain protein GII88_00265 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GII88_00270 ENOG4105KRN Transcriptional regulator, abrb family GII88_00275 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GII88_00280 ENOG4105F8V Hydrolase, tatD family GII88_00285 ENOG41069ER domain protein GII88_00295 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GII88_00300 ENOG4105XFA sporulation peptidase YabG GII88_00305 ENOG4105W42 Veg protein GII88_00310 ENOG4105XEW small acid-soluble spore protein GII88_00315 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GII88_00320 ENOG4105DFT pur operon repressor GII88_00325 ENOG4105KME endoribonuclease L-psp GII88_00330 ENOG4105K4W Could be involved in septation (By similarity) GII88_00335 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GII88_00340 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GII88_00345 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GII88_00360 ENOG4108JA2 transcriptioN-repair coupling factor GII88_00365 ENOG4108M14 stage v sporulation protein t GII88_00375 ENOG4108IY2 MazG family GII88_00380 ENOG41082I2 s4 domain protein GII88_00385 ENOG4105VYY sporulation protein yabp GII88_00400 ENOG41060GV RNA binding s1 domain protein GII88_00430 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GII88_00435 ENOG4108UGV hypoxanthine phosphoribosyltransferase GII88_00440 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GII88_00445 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GII88_00450 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GII88_00455 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase GII88_00460 ENOG4105C6T cysteine synthase GII88_00470 ENOG4105CRQ synthase (Component I) GII88_00475 ENOG4105DDQ anthranilate synthase GII88_00480 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GII88_00485 ENOG4105EEI dihydropteroate synthase GII88_00490 ENOG4105KRF dihydroneopterin aldolase GII88_00495 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GII88_00505 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GII88_00510 ENOG4105CRK lysyL-tRNA synthetase GII88_00595 ENOG4108Z0C Uvrb UvrC protein GII88_00600 ENOG41066A3 ATP guanido phosphotransferase GII88_00610 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GII88_00615 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GII88_00620 ENOG4105CTP PilT protein domain protein GII88_00625 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GII88_00630 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GII88_00635 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GII88_00640 ENOG4105D7W serine acetyltransferase GII88_00645 ENOG4105C8N cysteinyl-tRNA synthetase GII88_00650 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) GII88_00655 ENOG4105C2N RNA methyltransferase TrmH family group 3 GII88_00660 ENOG4105M0M Tetracycline resistance protein GII88_00665 ENOG4105QIV RNA polymerase GII88_00675 ENOG410683Z Preprotein translocase SecE subunit GII88_00680 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GII88_00685 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GII88_00690 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GII88_00695 ENOG4108VZM 50s ribosomal protein L10 GII88_00700 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GII88_00705 ENOG4107Y49 methyltransferase GII88_00710 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GII88_00715 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GII88_00720 ENOG4105XPM ribosomal protein GII88_00725 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GII88_00730 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GII88_00735 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GII88_00740 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GII88_00745 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GII88_00750 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GII88_00755 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GII88_00760 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GII88_00765 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GII88_00770 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GII88_00775 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GII88_00780 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GII88_00785 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GII88_00790 ENOG41082SA 50s ribosomal protein l29 GII88_00795 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GII88_00800 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GII88_00805 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GII88_00810 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GII88_00815 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GII88_00820 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GII88_00825 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GII88_00830 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GII88_00835 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GII88_00840 ENOG4105VPB 50S ribosomal protein L30 GII88_00845 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GII88_00850 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GII88_00855 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GII88_00860 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GII88_00870 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GII88_00880 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GII88_00885 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GII88_00890 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GII88_00895 ENOG4108ZT0 50S ribosomal protein l17 GII88_00900 ENOG4108JJB ABC transporter GII88_00905 ENOG4108JJB ABC transporter GII88_00910 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GII88_00915 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GII88_00920 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GII88_00925 ENOG4108UJD 30S ribosomal protein S9 GII88_00945 ENOG4105D1F ATP-binding protein GII88_00960 ENOG4108NMV polysaccharide deacetylase GII88_00990 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GII88_00995 ENOG410635T phage-like element pbsx protein GII88_01005 ENOG4108IMY Transcriptional regulator GII88_01075 ENOG4105CDU Replicative dna helicase GII88_01090 ENOG4105QBX endodeoxyribonuclease RusA GII88_01125 ENOG4106BHF GII88_01130 ENOG4106ANW SMI1_KNR4 GII88_01145 ENOG4105IG6 Phage terminase, large subunit GII88_01150 ENOG4108MDF Phage Portal Protein GII88_01155 ENOG4106CGH Phage Mu protein F like protein GII88_01160 ENOG4108U3J GII88_01195 ENOG41060SN GII88_01210 ENOG4105PQS phage protein GII88_01215 ENOG4105FR7 XkdM protein, phage-like element PBSX GII88_01220 ENOG4105MTC XkdN-like protein GII88_01230 ENOG4108FKH Transglycosylase SLT domain GII88_01230 ENOG4108FKH Transglycosylase SLT domain GII88_01235 ENOG4108WZM domain protein GII88_01240 ENOG4105X7F GII88_01250 ENOG4105MFU Protein of unknown function (DUF2634) GII88_01255 ENOG41066EA baseplate J family protein GII88_01260 ENOG410906S phage-like element pbsx protein xkdt GII88_01315 ENOG4108J9Q DNA ligase GII88_01340 ENOG4108A04 Beta-lactamase GII88_01365 ENOG4105EHZ conserved protein UCP016719 GII88_01370 ENOG4105D17 glycoside hydrolase, family 3 domain protein GII88_01390 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GII88_01395 ENOG4105EWC Purine nucleoside phosphorylase GII88_01430 ENOG4105EMN RNA polymerase sigma factor GII88_01440 ENOG4105C8B TIGR00159 family GII88_01445 ENOG4107U5W ybbr family GII88_01450 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GII88_01455 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GII88_01475 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GII88_01480 ENOG4105WAB arsR family transcriptional regulator GII88_01485 ENOG4108RWP Major Facilitator Superfamily protein GII88_01495 ENOG4105BZ1 (ABC) transporter GII88_01500 ENOG4107ZXU DSBA oxidoreductase GII88_01515 ENOG41075D4 Aminoglycoside 6-adenylyltransferase GII88_01545 ENOG4108MRH transcriptional regulatory protein GII88_01555 ENOG4105DUM transcriptional regulator, lysR family GII88_01565 ENOG4105E5W Transporter GII88_01570 ENOG4106DDH Sporulation-specific SASP protein GII88_01585 ENOG4105C7Z Conserved Protein GII88_01590 ENOG4107KNS GII88_01610 ENOG41068SY GII88_01630 ENOG4105C7Z Conserved Protein GII88_01640 ENOG4105DXI Major Facilitator superfamily GII88_01665 ENOG4107I77 yiaA/B two helix domain GII88_01690 ENOG410631K Membrane GII88_01695 ENOG4106AXJ AraC family transcriptional regulator GII88_01715 ENOG4107SCQ Iron-containing alcohol dehydrogenase GII88_01720 ENOG4105C8Q Methyl-accepting chemotaxis GII88_01725 ENOG4105DFW ABC transporter GII88_01740 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid GII88_01750 ENOG4108IQI permease GII88_01755 ENOG4108J5H Homocysteine s-methyltransferase GII88_01765 ENOG4105CI1 PTS System GII88_01770 ENOG4107TXC Transcriptional regulator GII88_01775 ENOG4108QY0 Membrane GII88_01800 ENOG4105CSV Glutaminase GII88_01815 ENOG4105KNA -acetyltransferase GII88_01825 ENOG4105NA0 Transcriptional regulator GII88_01835 ENOG4105DGI Alkaline phosphatase GII88_01840 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GII88_01845 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GII88_01850 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GII88_01855 ENOG4105C26 Dehydrogenase GII88_01860 ENOG4105DJB Major Facilitator Superfamily GII88_01865 ENOG4105EQX glucarate dehydratase GII88_01870 ENOG41073TP transcriptional regulator GII88_01875 ENOG4105CTX dehydratase GII88_01880 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GII88_01905 ENOG4108R1P GII88_01910 ENOG4106K80 GII88_01920 ENOG41067TZ transcriptional regulator, MarR family GII88_01945 ENOG4107TXC Transcriptional regulator GII88_01970 ENOG4106UX7 integral membrane protein GII88_01980 ENOG41060AI SEC-C motif GII88_01985 ENOG4105DA5 (ABC) transporter GII88_02010 ENOG4108KSA LysR family transcriptional regulator GII88_02015 ENOG4105MDS 4-oxalocrotonate tautomerase GII88_02045 ENOG4108W0I acetyltransferase GII88_02055 ENOG4105DPN Oligoendopeptidase f GII88_02060 ENOG4107BMA Transglycosylase associated protein GII88_02070 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GII88_02075 ENOG4105CQB FAD linked oxidase domain protein GII88_02080 ENOG4105VZJ PTS System GII88_02085 ENOG4105VCP PTS System GII88_02090 ENOG4105CK1 PTS System GII88_02095 ENOG4105F8D glycoside hydrolase family 4 GII88_02100 ENOG4108X79 transcriptional regulator GII88_02105 ENOG410901P UPF0249 protein GII88_02120 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases GII88_02125 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GII88_02140 ENOG4105KHC sulfurtransferase GII88_02150 ENOG4105DEN Luciferase family GII88_02155 ENOG4105Z8B NlpC/P60 family GII88_02165 ENOG4105CIG ABC transporter GII88_02170 ENOG4108RZE Tetr family transcriptional regulator GII88_02190 ENOG4108N0M stress protein GII88_02195 ENOG4106FN3 tellurium resistance protein GII88_02200 ENOG4106FN3 tellurium resistance protein GII88_02205 ENOG4107TS3 membrane protein, TerC GII88_02220 ENOG4108TTB tellurium resistance protein GII88_02230 ENOG4107QIV Cytochrome c biogenesis protein GII88_02240 ENOG4107SWG transcriptional regulator MERR family GII88_02275 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GII88_02280 ENOG410756H nucleotidyltransferase GII88_02290 ENOG4105C26 Dehydrogenase GII88_02295 ENOG4105CK7 Sodium proline symporter GII88_02300 ENOG4107YHD transcriptional regulator GII88_02310 ENOG4108PJD permease GII88_02315 ENOG4105I82 acetyl xylan esterase GII88_02335 ENOG4105E5Q amino acid AbC transporter GII88_02340 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein GII88_02345 ENOG4105NF4 modulator of drug activity GII88_02355 ENOG4105CS2 ec 3.2.1.21 GII88_02370 ENOG4107WDG serine threonine protein kinase GII88_02405 ENOG4105F38 ABC transporter, permease GII88_02410 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component GII88_02415 ENOG4105CEY Amp-dependent synthetase and ligase GII88_02435 ENOG4105SX7 Transporter GII88_02445 ENOG4105W8Z 4'-phosphopantetheinyl transferase GII88_02450 ENOG4108SA1 esterase GII88_02470 ENOG4105CJ1 ABC, transporter GII88_02495 ENOG4105CDA abc transporter atp-binding protein GII88_02500 ENOG4105DRP amino acid AbC transporter GII88_02510 ENOG4108JUB Transcriptional regulator GII88_02515 ENOG4105C8Y Acetylornithine aminotransferase GII88_02520 ENOG4108IQI permease GII88_02525 ENOG41066UZ arginase EC 3.5.3.1 GII88_02530 ENOG4106P55 Transcriptional regulator GII88_02535 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GII88_02540 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GII88_02545 ENOG41069ZX GII88_02550 ENOG41069ZX GII88_02590 ENOG4107EV6 Inherit from COG: YD repeat protein GII88_02610 ENOG4105C2F Histidine kinase GII88_02615 ENOG4105EQD regulatoR GII88_02620 ENOG4105DFW ABC transporter GII88_02630 ENOG4108HWW ABC transporter GII88_02635 ENOG4105DCM major facilitator superfamily GII88_02640 ENOG410645S MarR family Transcriptional regulator GII88_02645 ENOG4105C4C beta-galactosidase GII88_02650 ENOG4107T32 3-phytase (EC 3.1.3.8) GII88_02655 ENOG4105DUX Transporter GII88_02670 ENOG4105E1K spore germination protein GII88_02685 ENOG4107TXC Transcriptional regulator GII88_02695 ENOG4107WD8 ABC transporter, permease GII88_02700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GII88_02705 ENOG4105BZU Histidine kinase GII88_02715 ENOG4105CFH Aspartokinase GII88_02720 ENOG4105DHS permease protein GII88_02725 ENOG4105CM4 permease protein GII88_02730 ENOG4108IPW abc transporter atp-binding protein GII88_02745 ENOG4105R8C Transcriptional regulator GII88_02755 ENOG4108DBC nitroreductase GII88_02760 ENOG41067V3 Antibiotic biosynthesis monooxygenase GII88_02765 ENOG4105YVS arsR family transcriptional regulator GII88_02775 ENOG4108JPW Aminotransferase GII88_02780 ENOG4107QTZ amino acid GII88_02785 ENOG4105C26 Dehydrogenase GII88_02790 ENOG4108RNG Permease of the drug metabolite transporter GII88_02800 ENOG4105KTB nuclear export factor GLE1 GII88_02805 ENOG4108T5E Copper resistance protein GII88_02810 ENOG4108ZYE Transcriptional regulator GII88_02820 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GII88_02825 ENOG4108IFG nitrite reductase, (NAD(P)H) GII88_02830 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit GII88_02835 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GII88_02840 ENOG4105DRR Transcriptional regulator, GntR family GII88_02845 ENOG4105C8P )-transporter GII88_02870 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia GII88_02890 ENOG4108IUS Transketolase GII88_02900 ENOG4105E7W lamb ycsf family protein GII88_02905 ENOG4105C5A transporter GII88_02910 ENOG4105CFM UPF0317 protein GII88_02915 ENOG4105P4J Allophanate hydrolase, subunit 1 GII88_02925 ENOG4107258 Transcriptional regulator GII88_02930 ENOG4105XJB lipolytic protein G-D-S-L family GII88_02945 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GII88_02950 ENOG4105ETD TRANSCRIPTIONal GII88_02955 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GII88_02970 ENOG410606W general stress protein GII88_02980 ENOG4108RCF TRANSCRIPTIONal GII88_02985 ENOG4105VCH membrane GII88_03000 ENOG4105C9U ATP-dependent DNA helicase RecQ GII88_03005 ENOG4105C0X amino acid GII88_03015 ENOG4108M1A Chitin-binding protein GII88_03030 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GII88_03035 ENOG4107BMA Transglycosylase associated protein GII88_03040 ENOG4108IJ0 Aspartate ammonia-lyase GII88_03045 ENOG41087PP glycosyltransferase MGT family GII88_03050 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) GII88_03055 ENOG4105EU9 GII88_03065 ENOG41082W1 Cupin 2, conserved barrel domain protein GII88_03070 ENOG4105QVS general stress protein GII88_03075 ENOG4106F5Q Membrane GII88_03080 ENOG4105CK2 sodium dicarboxylate symporter GII88_03085 ENOG4105CJ1 ABC, transporter GII88_03100 ENOG4105FDT acyl-CoA dehydrogenase GII88_03115 ENOG4105SZ6 Thioredoxin GII88_03120 ENOG4105CPF Cell wall formation (By similarity) GII88_03125 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GII88_03135 ENOG4105C1J atp-dependent rna helicase GII88_03140 ENOG410905X membrane-flanked domain protein GII88_03145 ENOG4105CKV Membrane GII88_03155 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GII88_03160 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GII88_03170 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GII88_03175 ENOG4107MMM Anti-sigma-factor antagonist GII88_03180 ENOG4105FUA antagonist GII88_03185 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GII88_03190 ENOG4107SGM protein serine threonine phosphatase GII88_03210 ENOG41064BQ Phosphatase GII88_03220 ENOG4105ST3 Transcriptional regulator GII88_03225 ENOG4105EYF MMPL domain protein GII88_03280 ENOG4105VZ8 Transcriptional regulator GII88_03285 ENOG4105ECK Fatty Acid Desaturase GII88_03290 ENOG4105VEQ Cold shock protein GII88_03295 ENOG4105CPQ Dehydrogenase GII88_03310 ENOG4108U05 Transcriptional regulator GII88_03315 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 GII88_03330 ENOG4105KVH Transcriptional regulator GII88_03360 ENOG4107XCH Cyclase family GII88_03365 ENOG4105C85 amino acid GII88_03380 ENOG4105JVQ RNA Polymerase GII88_03385 ENOG4108P49 AntiSigma factor GII88_03390 ENOG4105EXC Acyl-transferase GII88_03395 ENOG4105C2C drug resistance transporter, Bcr CflA GII88_03405 ENOG4108NEV two component transcriptional regulator, LytTR family GII88_03415 ENOG4108Z6X (sortase) family GII88_03425 ENOG4107QNK )-transporter GII88_03465 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GII88_03470 ENOG4105K8N protein family UPF0079, ATPase GII88_03475 ENOG41072GX Peptidase M22 Glycoprotease GII88_03480 ENOG410801F ribosomal-protein-alanine acetyltransferase GII88_03485 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GII88_03490 ENOG4105C5H ABC transporter GII88_03500 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GII88_03505 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GII88_03510 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GII88_03520 ENOG4108TYN CAAX amino terminal protease family protein GII88_03525 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GII88_03530 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GII88_03570 ENOG41073R8 VanW family GII88_03585 ENOG4108RAV Conserved protein GII88_03595 ENOG4108X07 Tetr family transcriptional regulator GII88_03600 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GII88_03610 ENOG4105K78 MarR family Transcriptional regulator GII88_03615 ENOG4108VHC Short-chain dehydrogenase reductase Sdr GII88_03620 ENOG4105EBR Carboxylesterase GII88_03630 ENOG41087YS Phage shock protein A GII88_03635 ENOG4105DQX Zinc finger domain GII88_03640 ENOG4108WV1 Pfam:DUF477 GII88_03655 ENOG4108NGU Transcriptional regulator GII88_03660 ENOG4105N14 lysine exporter protein LysE YggA GII88_03670 ENOG4105CNI cell division protein FtsW GII88_03675 ENOG4105CNI cell division protein FtsW GII88_03700 ENOG4108ZJ4 polysaccharide deacetylase GII88_03705 ENOG4105E5K Alpha-amylase GII88_03710 ENOG4105FKQ transcriptional regulator GII88_03715 ENOG4108IUK alpha amylase, catalytic GII88_03720 ENOG4107FKK extracellular solute-binding protein family 1 GII88_03725 ENOG4105D56 permease protein GII88_03730 ENOG4105EG2 ABC transporter, permease GII88_03745 ENOG4105CG3 alpha amylase, catalytic region GII88_03750 ENOG4107URF beta-phospho-glucomutase GII88_03755 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GII88_03760 ENOG4105GVJ transcriptional regulator GII88_03815 ENOG4108W3Q Transcriptional regulator GII88_03820 ENOG4107STQ Multicopper oxidase GII88_03840 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GII88_03855 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GII88_03865 ENOG4105C7N Xanthine uracil vitamin C permease GII88_03880 ENOG4108U5N UPF0316 protein GII88_03890 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GII88_03895 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GII88_03900 ENOG4105C83 adenylosuccinate lyase GII88_03905 ENOG4105C8V SAICAR synthetase GII88_03910 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GII88_03920 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GII88_03930 ENOG4105CXB phosphoribosylaminoimidazole synthetase GII88_03935 ENOG4108V3E phosphoribosylglycinamide formyltransferase GII88_03940 ENOG4105DC1 bifunctional purine biosynthesis protein purh GII88_03945 ENOG4105C12 Phosphoribosylglycinamide synthetase GII88_03960 ENOG4106A3M Cytochrome p-450 GII88_03985 ENOG4108R5T secreted protein GII88_03990 ENOG4105KGF protein, YerC YecD GII88_04000 ENOG4105C4R Atp-dependent dna helicase GII88_04005 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GII88_04020 ENOG4108M21 GII88_04030 ENOG4105MUZ Protein of unknown function DUF2620 GII88_04035 ENOG4106M0N transport system permease protein GII88_04040 ENOG41080QX K07048 phosphotriesterase-related protein GII88_04045 ENOG4106PKC pyridoxal phosphate binding GII88_04050 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GII88_04055 ENOG4108626 Racemase GII88_04060 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GII88_04065 ENOG4105KT7 mgtC SapB transporter GII88_04070 ENOG4105CK7 Sodium proline symporter GII88_04075 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GII88_04080 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GII88_04085 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GII88_04100 ENOG4105D3P Mannan endo-1,4-beta-mannosidase GII88_04105 ENOG4108IG5 Transcriptional regulator GII88_04120 ENOG4105D9U N-acetyltransferase GII88_04125 ENOG4105DU0 nucleoside hydrolase GII88_04130 ENOG4105CBD Diacylglycerol kinase GII88_04135 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GII88_04145 ENOG4105C5Y PTS System GII88_04150 ENOG4105CS2 ec 3.2.1.21 GII88_04155 ENOG4105CID antiterminator GII88_04160 ENOG410780I phosphoprotein phosphatase activity GII88_04175 ENOG4105CDY transcriptional regulatory protein GII88_04190 ENOG4105C26 Dehydrogenase GII88_04195 ENOG4105FKZ Methyl-accepting chemotaxis GII88_04200 ENOG4105C8P )-transporter GII88_04205 ENOG4105C5H ABC transporter GII88_04215 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) GII88_04220 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase GII88_04230 ENOG4105CKI cobalamin synthesis protein GII88_04235 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) GII88_04240 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GII88_04245 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GII88_04250 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GII88_04255 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GII88_04260 ENOG4106A3M Cytochrome p-450 GII88_04270 ENOG4107SWG transcriptional regulator MERR family GII88_04275 ENOG4105DXB Major Facilitator superfamily GII88_04280 ENOG4105C5H ABC transporter GII88_04285 ENOG4105FDU atp-dependent rna helicase GII88_04290 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GII88_04305 ENOG4107QPK )-transporter GII88_04345 ENOG41082BM Transcriptional regulator, arsr family GII88_04350 ENOG410855V Acylphosphatase GII88_04355 ENOG4108RPX mosc domain containing protein GII88_04365 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) GII88_04385 ENOG4105C5Y PTS System GII88_04390 ENOG4105CG3 alpha amylase, catalytic region GII88_04395 ENOG4107414 GntR family transcriptional regulator GII88_04420 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GII88_04425 ENOG4105D7W serine acetyltransferase GII88_04430 ENOG4108IAJ Nad-dependent epimerase dehydratase GII88_04445 ENOG4107TVC Glycosyl transferase, family 2 GII88_04460 ENOG4107QQG Dehydrogenase GII88_04470 ENOG4105KVH Transcriptional regulator GII88_04475 ENOG4108RCM Nitroreductase GII88_04480 ENOG4105CGH 5'-nucleotidase GII88_04485 ENOG4107RKG DJ-1/PfpI family GII88_04495 ENOG4105BZG amino acid carrier protein GII88_04500 ENOG4105KJF protein tyrosine phosphatase GII88_04510 ENOG4107U9T Pfam:Ribonuclease_BN GII88_04515 ENOG4108ISG Major Facilitator GII88_04525 ENOG4105UPD Calcium Proton GII88_04550 ENOG4105DCT glycerol dehydrogenase GII88_04560 ENOG4105D7N magnesium and cobalt transport protein CorA GII88_04570 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GII88_04610 ENOG41079KZ Major Facilitator Superfamily GII88_04630 ENOG4105EVH UPF0753 protein GII88_04635 ENOG4108TWJ NADH dehydrogenase subunit 5 GII88_04640 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GII88_04650 ENOG4107RUY (E1 component), alpha subunit GII88_04660 ENOG4107QKR Dehydrogenase GII88_04670 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GII88_04675 ENOG4105KK4 UPF0060 membrane protein GII88_04680 ENOG4105F8D glycoside hydrolase family 4 GII88_04685 ENOG4108Q3X Transcriptional regulator GII88_04690 ENOG4105CI1 PTS System GII88_04705 ENOG4105KVH Transcriptional regulator GII88_04715 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GII88_04720 ENOG4105E4I Glycoside hydrolase family 28 GII88_04725 ENOG4105DSG hydrolase family 43 GII88_04730 ENOG4106HBX Transcriptional Regulator AraC Family GII88_04740 ENOG4105DYS nad(p)h dehydrogenase (quinone) GII88_04765 ENOG4105JAB phenazine biosynthesis protein, phzf family GII88_04770 ENOG4107Y03 Nitroreductase GII88_04790 ENOG4105ECP epimerase GII88_04795 ENOG410691R Modulates RecA activity (By similarity) GII88_04825 ENOG4105CKK Glycosyl transferase, family 2 GII88_04835 ENOG4105EJV Membrane GII88_04840 ENOG41067AE Membrane-bound metal-dependent hydrolase GII88_04845 ENOG4105CEN a g-specific adenine glycosylase GII88_04850 ENOG4106BXE GII88_04855 ENOG4105CAN Short-chain dehydrogenase reductase Sdr GII88_04875 ENOG4105BZ1 (ABC) transporter GII88_04880 ENOG4105C3U ABC transporter GII88_04885 ENOG4108JQ7 (ABC) transporter GII88_04890 ENOG4105DEF Extracellular solute-binding protein, family 5 GII88_04895 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GII88_04900 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GII88_04905 ENOG4107NBY Membrane GII88_04910 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GII88_04915 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GII88_04920 ENOG4105G5W regulator Fur family GII88_04925 ENOG4105TUA UPF0295 protein GII88_05030 ENOG4105C22 threonyL-tRNA synthetase GII88_05040 ENOG4105FF2 Type I DHQase GII88_05045 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GII88_05050 ENOG4105D7T ABC transporter GII88_05055 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein GII88_05060 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GII88_05065 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GII88_05070 ENOG4107D63 GII88_05075 ENOG4105VZ8 Transcriptional regulator GII88_05085 ENOG4105DA5 (ABC) transporter GII88_05105 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GII88_05120 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GII88_05130 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GII88_05150 ENOG4105CYN Serine protein kinase GII88_05155 ENOG4106AKX UPF0229 protein GII88_05160 ENOG4105CW7 secretion protein, HlyD family GII88_05165 ENOG4105C0R drug resistance transporter emrb qaca subfamily GII88_05170 ENOG4105CS1 NAD(P)H quinone oxidoreductase GII88_05185 ENOG4105CZV ABC transporter GII88_05190 ENOG4105CZV ABC transporter GII88_05195 ENOG4105CJ1 ABC, transporter GII88_05200 ENOG4108TU7 Inherit from COG: (ABC) transporter GII88_05205 ENOG4105VEQ Cold shock protein GII88_05210 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GII88_05215 ENOG4108UMI ABC transporter, permease GII88_05225 ENOG4107R6U sodium dicarboxylate symporter GII88_05255 ENOG4105BZU Histidine kinase GII88_05270 ENOG4108YBP pseudouridine synthase GII88_05280 ENOG41080XP Cbs domain GII88_05285 ENOG4107YBY Hydrolase GII88_05290 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GII88_05295 ENOG4105C5H ABC transporter GII88_05300 ENOG4105TMB Formate nitrite transporter GII88_05305 ENOG4105RK9 auxin efflux carrier GII88_05310 ENOG4105CB2 alcohol dehydrogenase GII88_05315 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GII88_05325 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GII88_05330 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GII88_05350 ENOG4105BZU Histidine kinase GII88_05355 ENOG4105WH1 Two component transcriptional regulator luxr family GII88_05375 ENOG4105KPV Transcriptional regulator GII88_05380 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GII88_05385 ENOG4105ED1 spovr family GII88_05400 ENOG4105BZN citrate synthase GII88_05410 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GII88_05415 ENOG4105C8J )-transporter GII88_05425 ENOG41086D8 Transcriptional regulator GII88_05430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GII88_05445 ENOG4105J37 GII88_05450 ENOG4108AEY RNA polymerase sigma factor GII88_05455 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein GII88_05465 ENOG4105F6E Acyl-transferase GII88_05470 ENOG4105KAF membrAne GII88_05480 ENOG4105U5Y Transcriptional regulator GII88_05485 ENOG4105C37 (CBS) domain GII88_05495 ENOG4105C37 (CBS) domain GII88_05525 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GII88_05535 ENOG4105D64 Mechanosensitive ion channel GII88_05540 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GII88_05550 ENOG4107VMI polysaccharide deacetylase GII88_05555 ENOG4105F0I Aminotransferase GII88_05565 ENOG4108N2V aldose 1-epimerase GII88_05595 ENOG4105BZ1 (ABC) transporter GII88_05600 ENOG4105BZ1 (ABC) transporter GII88_05635 ENOG410839P GII88_05645 ENOG4106MP8 UPF0754 membrane protein GII88_05650 ENOG4105WZB UPF0342 protein GII88_05665 ENOG4105D4P Coproporphyrinogen iii oxidase GII88_05670 ENOG4107S91 Sodium hydrogen exchanger GII88_05675 ENOG4105NCW Trka-c domain protein GII88_05685 ENOG4105CGU Enoyl-CoA hydratase GII88_05705 ENOG4108IUX (ABC) transporter GII88_05710 ENOG4105RHA ABC transporter, permease GII88_05715 ENOG4107VRP DNA repair exonuclease GII88_05725 ENOG4105EQI Metal Dependent Phosphohydrolase GII88_05735 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GII88_05780 ENOG4105NBU tryptophan transport protein GII88_05785 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GII88_05790 ENOG4105K59 histidine triad (HIT) protein GII88_05820 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GII88_05825 ENOG4105BZ4 penicillin-binding protein GII88_05830 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GII88_05835 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GII88_05840 ENOG4105C1Q protoporphyrinogen oxidase GII88_05850 ENOG4105ECB domain protein GII88_05860 ENOG4105DER m42 family GII88_05875 ENOG4106AXD GII88_05880 ENOG4108RQ5 Beta-lactamase domain-containing protein GII88_05885 ENOG4105DF9 Lipoate-protein, ligase GII88_05890 ENOG4105CEY Amp-dependent synthetase and ligase GII88_05900 ENOG4108JCI Transcriptional regulator GII88_05915 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GII88_05920 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GII88_05925 ENOG4108UZ3 Transporter GII88_05930 ENOG4108HUF Transporter GII88_05935 ENOG4105DQ5 transport system permease protein GII88_05940 ENOG4108U1V ABC transporter, permease GII88_05945 ENOG4107TB6 phosphoglycerate mutase GII88_05950 ENOG4106YBV Methyl-accepting chemotaxis GII88_05970 ENOG4105XVF Competence transcription factor GII88_05975 ENOG41060YP GII88_05990 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin GII88_06000 ENOG4105G9B Transcriptional regulator GII88_06010 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) GII88_06015 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GII88_06020 ENOG4105S0E allantoin catabolism protein GII88_06025 ENOG4105DG4 malate L-lactate dehydrogenase GII88_06030 ENOG4105DG4 malate L-lactate dehydrogenase GII88_06035 ENOG4107R1Q Membrane protein FdrA GII88_06040 ENOG4107REC cytoplasmic protein GII88_06050 ENOG4105C5B carbamate kinase GII88_06055 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) GII88_06065 ENOG410780I phosphoprotein phosphatase activity GII88_06095 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GII88_06100 ENOG4105I1K ABC transporter GII88_06110 ENOG4108KK1 membrane protein AbrB duplication GII88_06125 ENOG4105WEF catalase GII88_06130 ENOG4105CEY Amp-dependent synthetase and ligase GII88_06135 ENOG4106K7D Major facilitator family transporter GII88_06145 ENOG4105BZU Histidine kinase GII88_06150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GII88_06160 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GII88_06165 ENOG4105E0C molybdate abc transporter GII88_06175 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GII88_06185 ENOG4105EYH Exonuclease GII88_06220 ENOG410751J GII88_06240 ENOG4105ERH Fumarylacetoacetate hydrolase GII88_06260 ENOG4105CAQ asparagine synthetase GII88_06270 ENOG4108YZA Nitrogen regulatory protein pii GII88_06275 ENOG4105UQX Mate efflux family protein GII88_06280 ENOG4106HBX Transcriptional Regulator AraC Family GII88_06290 ENOG4105ETE Transcriptional regulator (LacI family GII88_06295 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GII88_06300 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GII88_06310 ENOG4105DY8 decarboxylase GII88_06335 ENOG4105MA6 gCN5-related N-acetyltransferase GII88_06340 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GII88_06345 ENOG4105D29 Helix-turn-helix type 11 domain protein GII88_06360 ENOG4108VPT UPF0234 protein GII88_06365 ENOG4105QNR S1 RNA binding domain protein GII88_06380 ENOG4105EPR degv family GII88_06385 ENOG4107AYK membrAne GII88_06395 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) GII88_06400 ENOG41073B9 GII88_06405 ENOG4108KP7 hydrolase GII88_06410 ENOG4108MXZ Esterase GII88_06415 ENOG4105VG1 fes assembly suf system protein GII88_06425 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GII88_06430 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GII88_06435 ENOG4105CAS nag kinase GII88_06440 ENOG4105C8Y Acetylornithine aminotransferase GII88_06445 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GII88_06455 ENOG4105DBV ornithine carbamoyltransferase GII88_06460 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GII88_06485 ENOG4107RMD Basic membrane lipoprotein GII88_06500 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GII88_06505 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GII88_06515 ENOG4105C3U ABC transporter GII88_06520 ENOG4108JQ7 (ABC) transporter GII88_06535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GII88_06560 ENOG4105C31 Tryptophanyl-tRNA synthetase GII88_06565 ENOG4108J59 Extracellular solute-binding protein, family 5 GII88_06570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GII88_06575 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GII88_06585 ENOG4108JQ7 (ABC) transporter GII88_06595 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) GII88_06600 ENOG4108ZCF integral membrane protein GII88_06610 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis GII88_06630 ENOG4108V9W transcriptional regulatory protein GII88_06635 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GII88_06645 ENOG4105DPN Oligoendopeptidase f GII88_06650 ENOG4105T58 Dithiol-disulfide isomerase GII88_06655 ENOG4108Z18 K06886 hemoglobin GII88_06660 ENOG4105E4C Lytic transglycosylase catalytic GII88_06665 ENOG4105MIX Adenylate cyclase GII88_06670 ENOG4106EFP UPF0738 protein GII88_06680 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GII88_06685 ENOG4105EMS pseudouridine synthase GII88_06690 ENOG4107S1Q Phosphatase GII88_06705 ENOG4105ETU transcriptional activator (TenA GII88_06710 ENOG4108VEU Thiamine monophosphate synthase GII88_06725 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GII88_06730 ENOG4105D06 uba thif-type nad fad binding protein GII88_06735 ENOG4105DWF phosphomethylpyrimidine kinase GII88_06740 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GII88_06745 ENOG4107A88 GII88_06795 ENOG4105ENA helicase GII88_06805 ENOG4107T5V SNARE associated Golgi GII88_06810 ENOG4105CMR udp-glucose 4-epimerase GII88_06815 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GII88_06830 ENOG4108ZMI UPF0477 protein GII88_06855 ENOG4105C28 cystathionine GII88_06860 ENOG4105C28 cystathionine GII88_06865 ENOG4105JHY Membrane GII88_06880 ENOG4105FQP Beta-lactamase GII88_06885 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase GII88_06905 ENOG4108UW5 maltose o-acetyltransferase GII88_06915 ENOG4105DUM transcriptional regulator, lysR family GII88_06920 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GII88_06925 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GII88_06940 ENOG4108Q5Y Membrane GII88_06945 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GII88_06955 ENOG41069ER domain protein GII88_06960 ENOG4105C0R drug resistance transporter emrb qaca subfamily GII88_06965 ENOG4105J7D transcriptional regulator GII88_06990 ENOG4105K7W phage-related replication protein GII88_06995 ENOG410635T phage-like element pbsx protein GII88_07040 ENOG4108TFU terminase (Small subunit) GII88_07045 ENOG4105IG6 Phage terminase, large subunit GII88_07050 ENOG4108MDF Phage Portal Protein GII88_07075 ENOG41060SN GII88_07090 ENOG4105PQS phage protein GII88_07095 ENOG4105FR7 XkdM protein, phage-like element PBSX GII88_07100 ENOG4105MTC XkdN-like protein GII88_07110 ENOG4108FKH Transglycosylase SLT domain GII88_07115 ENOG4108WZM domain protein GII88_07120 ENOG4105X7F GII88_07130 ENOG4105MFU Protein of unknown function (DUF2634) GII88_07135 ENOG41066EA baseplate J family protein GII88_07140 ENOG410906S phage-like element pbsx protein xkdt GII88_07150 ENOG41068G1 GII88_07170 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GII88_07175 ENOG4107XBN GntR Family Transcriptional Regulator GII88_07180 ENOG4105CPQ Dehydrogenase GII88_07185 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GII88_07190 ENOG4105DMW Dehydrogenase reductase GII88_07195 ENOG4105CPQ Dehydrogenase GII88_07200 ENOG4108I5G Major Facilitator superfamily GII88_07215 ENOG4105CJ3 phosphate transporter GII88_07220 ENOG4107GRR phosphate transport regulator GII88_07225 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GII88_07235 ENOG4105C2F Histidine kinase GII88_07240 ENOG4105EQD regulatoR GII88_07245 ENOG410769Z extracellular solute-binding protein family 1 GII88_07250 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GII88_07255 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GII88_07260 ENOG4105F5H Glycosyl Hydrolase Family 88 GII88_07265 ENOG41075H3 AraC family transcriptional regulator GII88_07270 ENOG4107TDE lipolytic protein G-D-S-L family GII88_07285 ENOG4105CX8 fg-gap repeat protein GII88_07295 ENOG4107TDE lipolytic protein G-D-S-L family GII88_07300 ENOG4105CX8 fg-gap repeat protein GII88_07305 ENOG4105CPC Aldo Keto reductase GII88_07310 ENOG4107TDE lipolytic protein G-D-S-L family GII88_07320 ENOG4105EKC GII88_07325 ENOG4105E0S extracellular solute-binding protein family 1 GII88_07335 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GII88_07340 ENOG4107R7I amino acid GII88_07355 ENOG4105C0H protease GII88_07365 ENOG4108ME1 Peptidase M55 D-aminopeptidase GII88_07370 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GII88_07375 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GII88_07380 ENOG4105C3U ABC transporter GII88_07390 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GII88_07400 ENOG4107SN7 NLP P60 protein GII88_07405 ENOG4108JQ7 (ABC) transporter GII88_07410 ENOG4107TUM Amidinotransferase GII88_07415 ENOG4108S4H thioesterase Superfamily protein GII88_07425 ENOG4108J20 pectate lyase GII88_07450 ENOG410839T multidrug resistance protein GII88_07455 ENOG41080TC multidrug resistance protein GII88_07460 ENOG4105CIY formyltetrahydrofolate deformylase GII88_07465 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GII88_07470 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GII88_07480 ENOG4105K56 Transcriptional regulator GII88_07485 ENOG4108ZHJ Organic hydroperoxide resistance protein GII88_07495 ENOG4107Y2X deaminase GII88_07500 ENOG4105CVJ phosphoglycerate mutase GII88_07515 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GII88_07520 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GII88_07530 ENOG4105CJW magnesium transporter GII88_07540 ENOG4105V75 Transcriptional regulator GII88_07560 ENOG4105DQE DNA ligase GII88_07565 ENOG4105FDF Could be involved in DNA repair (By similarity) GII88_07570 ENOG4105BZU Histidine kinase GII88_07575 ENOG4107T5V SNARE associated Golgi GII88_07580 ENOG4107TS3 membrane protein, TerC GII88_07585 ENOG4108WZW RNA polymerase sigma GII88_07595 ENOG410681C small acid-soluble spore protein GII88_07605 ENOG4105D0M Protease HtpX homolog GII88_07615 ENOG4107RVG penicillin-binding protein GII88_07630 ENOG4108TGC Acyltransferase GII88_07635 ENOG4105BZU Histidine kinase GII88_07640 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GII88_07645 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GII88_07655 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GII88_07665 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate GII88_07675 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GII88_07680 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GII88_07695 ENOG4105BZU Histidine kinase GII88_07700 ENOG41090MY MarR family Transcriptional regulator GII88_07705 ENOG4105ER2 Ompa motb domain protein GII88_07710 ENOG4105E14 MotA TolQ exbB proton channel GII88_07720 ENOG4108K88 Membrane GII88_07725 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GII88_07730 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase GII88_07735 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GII88_07740 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GII88_07750 ENOG4105NX3 Membrane GII88_07755 ENOG4105VMP Transcriptional regulator GII88_07800 ENOG4105F0V Cell wall hydrolase GII88_07815 ENOG4105C59 p-type ATPase GII88_07820 ENOG4105DC7 peptidase M24 GII88_07835 ENOG4105CID antiterminator GII88_07845 ENOG4105KRI phosphocarrier protein (HPr GII88_07850 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GII88_07860 ENOG4105F6S Spore photoproduct lyase GII88_07870 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GII88_07875 ENOG4105CHR reductase GII88_07880 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GII88_07885 ENOG4105K4I Scp-like extracellular GII88_07895 ENOG4105BZU Histidine kinase GII88_07900 ENOG4105CHM Aminotransferase GII88_07915 ENOG4107R88 Chemotaxis protein (CheV) GII88_07920 ENOG4105UIN GII88_07930 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein GII88_07940 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GII88_07945 ENOG4105EPM Diguanylate phosphodiesterase GII88_07955 ENOG4107IN1 Protein of unknown function (DUF1797) GII88_07960 ENOG4108XRC Protein of unknown function (DUF458) GII88_07990 ENOG4105NQC Flavodoxin GII88_07995 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GII88_08010 ENOG4105D3R alkyl hydroperoxide reductase GII88_08015 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GII88_08030 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GII88_08035 ENOG4105D06 uba thif-type nad fad binding protein GII88_08040 ENOG4105CVM Molybdenum cofactor synthesis domain protein GII88_08045 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GII88_08050 ENOG4108ZAF Molybdopterin GII88_08055 ENOG41067WU Molybdopterin converting factor (Subunit 1) GII88_08065 ENOG4105BZ1 (ABC) transporter GII88_08070 ENOG4105BZ1 (ABC) transporter GII88_08080 ENOG4107X8C Efflux transporter RND family MFP subunit GII88_08085 ENOG4105C19 ABC transporter GII88_08090 ENOG4107RBB ABC transporter, permease GII88_08095 ENOG4105E98 transcriptional regulator DeoR family GII88_08100 ENOG4105DE4 1-phosphofructokinase GII88_08105 ENOG4105DM4 PTS System GII88_08110 ENOG4105C3F Signal peptidase i GII88_08125 ENOG4105C5H ABC transporter GII88_08155 ENOG4105BZU Histidine kinase GII88_08160 ENOG4107ZYR domain protein GII88_08170 ENOG4105CN5 Metallo-Beta-Lactamase GII88_08180 ENOG4108X4Q Hydrolase GII88_08190 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GII88_08210 ENOG4105CPP Dehydrogenase, E1 component GII88_08215 ENOG4105C7S Dehydrogenase GII88_08220 ENOG4107QN2 dihydrolipoyl dehydrogenase GII88_08235 ENOG4105CXN decarboxylase GII88_08240 ENOG4105WBI UPF0223 protein GII88_08255 ENOG4105ECY inositol monophosphatase GII88_08290 ENOG4105CI3 gtp-binding protein typa GII88_08295 ENOG4105QA2 GII88_08300 ENOG4108INS Transcriptional regulator GII88_08305 ENOG4107SCK Monooxygenase GII88_08320 ENOG4108IAB Phoh family GII88_08330 ENOG4105CSV Glutaminase GII88_08335 ENOG4105ZPI UPF0358 protein GII88_08340 ENOG4105CNI cell division protein FtsW GII88_08345 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GII88_08355 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GII88_08365 ENOG4105BZ9 Cytochrome C oxidase, subunit I GII88_08370 ENOG4105CCU oxidase (Subunit III) GII88_08375 ENOG41064X9 cytochrome C oxidase subunit IV GII88_08390 ENOG41080XQ Signal transduction protein with cbs domains GII88_08395 ENOG4106UY4 Inherit from COG: Scp-like extracellular GII88_08420 ENOG4106H78 methyltransferase GII88_08425 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GII88_08430 ENOG4105H20 Sporulation integral membrane protein YlbJ GII88_08435 ENOG41063PX domain protein GII88_08440 ENOG4105CDE UPF0348 protein GII88_08445 ENOG4105KNH Nucleic acid-binding protein GII88_08450 ENOG41067VY 50S ribosomal protein L32 GII88_08470 ENOG41074B2 UPF0747 protein GII88_08475 ENOG4108V6E Cell division protein mraZ GII88_08480 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GII88_08490 ENOG4105CJN penicillin-binding protein GII88_08495 ENOG4105CJN penicillin-binding protein GII88_08500 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GII88_08505 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GII88_08510 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GII88_08515 ENOG4105CNI cell division protein FtsW GII88_08520 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GII88_08525 ENOG4105D4A Cell wall formation (By similarity) GII88_08530 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) GII88_08535 ENOG4108R2U division initiation protein GII88_08545 ENOG4105K67 small basic protein GII88_08550 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GII88_08555 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GII88_08575 ENOG4105FFI sigma-e processing peptidase spoiiga GII88_08580 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GII88_08590 ENOG4105DKW ABC transporter GII88_08595 ENOG4105DHI Methyltransferase GII88_08600 ENOG4105WR5 sporulation protein, YlmC YmxH family GII88_08605 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GII88_08610 ENOG4105DFA alanine racemase domain protein GII88_08615 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GII88_08620 ENOG41067XK integral membrane protein GII88_08625 ENOG4105DBK s4 domain protein GII88_08645 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GII88_08650 ENOG4105C34 Pseudouridine synthase GII88_08655 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GII88_08665 ENOG4105CXT aspartate transcarbamylase GII88_08670 ENOG4105CD3 dihydroorotase GII88_08675 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GII88_08680 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GII88_08685 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GII88_08690 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) GII88_08695 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GII88_08710 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GII88_08730 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GII88_08735 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GII88_08740 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GII88_08745 ENOG4105F23 Fibronectin-binding protein GII88_08755 ENOG4105DSJ YicC domain protein GII88_08760 ENOG4105KC4 UPF0296 protein GII88_08765 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GII88_08770 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GII88_08775 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GII88_08780 ENOG4105C25 Primosomal protein n' GII88_08785 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GII88_08790 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GII88_08795 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GII88_08800 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GII88_08805 ENOG4108ZF3 Phosphatase GII88_08810 ENOG4105D9P serine threonine protein kinase GII88_08815 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GII88_08820 ENOG4105DJV ribulose-phosphate 3-epimerase GII88_08825 ENOG4105FJ0 thiamine GII88_08835 ENOG4105VB9 50S ribosomal protein l28 GII88_08840 ENOG4108ZAA Alkaline-shock protein GII88_08845 ENOG4105DP4 dak2 domain fusion protein ylov GII88_08855 ENOG4105EJQ L-serine dehydratase GII88_08860 ENOG4105CB5 ATP-dependent DNA helicase recG GII88_08865 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) GII88_08870 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GII88_08875 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GII88_08880 ENOG4105CHR reductase GII88_08885 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GII88_08890 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GII88_08895 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GII88_08900 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GII88_08905 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) GII88_08915 ENOG4105K5M 30s ribosomal protein S16 GII88_08920 ENOG4108BW8 UPF0109 protein GII88_08930 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GII88_08935 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GII88_08940 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GII88_08945 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GII88_08950 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GII88_08960 ENOG4105VM1 flagellar GII88_08965 ENOG4105CMV Succinyl-CoA synthetase subunit beta GII88_08970 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GII88_08975 ENOG4105C79 DNA protecting protein DprA GII88_08980 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GII88_08985 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) GII88_08990 ENOG4108HE4 integrase family GII88_08995 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GII88_09000 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GII88_09005 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) GII88_09010 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GII88_09015 ENOG4108ZC9 flagellar basal-body rod protein flgc GII88_09020 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GII88_09025 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GII88_09030 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GII88_09045 ENOG4106YF4 Flagellar biosynthesis chaperone GII88_09055 ENOG410696Y Flagellar hook-length control protein GII88_09060 ENOG410822I Flagellar hook capping protein GII88_09065 ENOG4108JQA flagellar GII88_09070 ENOG41068WV flagellar FlbD family protein GII88_09080 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GII88_09085 ENOG4105DD5 Flagellar motor switch protein GII88_09090 ENOG4107YTP response regulator receiver protein GII88_09100 ENOG4105CN7 Flagellar biosynthetic protein FliP GII88_09105 ENOG4105VS8 Flagellar biosynthetic protein fliq GII88_09110 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GII88_09115 ENOG4105D00 flagellar biosynthetic protein flhB GII88_09120 ENOG4105D7B Flagellar biosynthesis protein flha GII88_09125 ENOG4105FZW flagellar biosynthesis regulator FlhF GII88_09135 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GII88_09140 ENOG4105CBS Chea signal transduction histidine kinase GII88_09145 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis GII88_09155 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GII88_09160 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GII88_09170 ENOG4105CE9 30S ribosomal protein S2 GII88_09175 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GII88_09185 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GII88_09190 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GII88_09195 ENOG4105KNE Phosphatidate cytidylyltransferase GII88_09205 ENOG4105DZP Membrane-associated zinc metalloprotease GII88_09215 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GII88_09230 ENOG4105CYP glycoside hydrolase, family GII88_09245 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GII88_09250 ENOG4105CHV Transcription elongation factor NusA GII88_09255 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GII88_09260 ENOG4105VHM ribosomal protein GII88_09265 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GII88_09270 ENOG4105W7A Protein of unknown function (DUF503) GII88_09275 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GII88_09280 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GII88_09285 ENOG4105DTN riboflavin biosynthesis protein ribF GII88_09290 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GII88_09295 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GII88_09305 ENOG4105C1V Peptidase, M16 GII88_09315 ENOG4105E35 Dipicolinate synthase subunit A GII88_09320 ENOG4108S0H Dipicolinic acid synthetase, b subunit GII88_09325 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GII88_09335 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GII88_09345 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GII88_09355 ENOG4105CNU cell division protein FtsK GII88_09360 ENOG4105FDP GntR family transcriptional regulator GII88_09380 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GII88_09385 ENOG4105XZV Protein of unknown function (DUF3243) GII88_09400 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GII88_09405 ENOG4105CEV competence damage-inducible protein GII88_09410 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GII88_09420 ENOG4105D48 metallophosphoesterase GII88_09425 ENOG4105MCT stage V sporulation protein S GII88_09430 ENOG4108IGT Dipeptidase GII88_09435 ENOG4105CPQ Dehydrogenase GII88_09440 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GII88_09445 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GII88_09460 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GII88_09465 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GII88_09475 ENOG4107EV6 Inherit from COG: YD repeat protein GII88_09490 ENOG4105CKI cobalamin synthesis protein GII88_09500 ENOG4107TCE N-acetyltransferase GII88_09520 ENOG4105XPP Protein of unknown function (DUF1275) GII88_09525 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GII88_09550 ENOG41080BT SNARE associated Golgi GII88_09555 ENOG4105FQP Beta-lactamase GII88_09560 ENOG41087PP glycosyltransferase MGT family GII88_09565 ENOG4107QTZ amino acid GII88_09585 ENOG4105M4P Tetr family transcriptional regulator GII88_09590 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein GII88_09595 ENOG4107S9F NmrA family GII88_09605 ENOG4108X3M OsmC Ohr family protein GII88_09610 ENOG4107E54 Small Multidrug Resistance protein GII88_09630 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GII88_09635 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GII88_09650 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GII88_09655 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GII88_09660 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GII88_09665 ENOG4105U6W MutT NUDIX family protein GII88_09675 ENOG4108UNV SUF system FeS assembly protein, NifU family GII88_09680 ENOG4105G5W regulator Fur family GII88_09685 ENOG4105DRR Transcriptional regulator, GntR family GII88_09725 ENOG4105PF9 Transcriptional regulator GII88_09775 ENOG4106F1P AAA ATPase, central domain protein GII88_09780 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GII88_09785 ENOG4105CXI aluminum resistance protein GII88_09790 ENOG4105KV4 Transcriptional regulator GII88_09795 ENOG4105C5F glutamine synthetase GII88_09820 ENOG4105K59 histidine triad (HIT) protein GII88_09890 ENOG4108MK9 spermidine N(1)-acetyltransferase GII88_09930 ENOG41062JF Transcriptional regulator GII88_09935 ENOG41090MY MarR family Transcriptional regulator GII88_09940 ENOG4108TVJ Nitroreductase GII88_09945 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GII88_09950 ENOG4107XWI flavin reductase domain protein, FMN-binding GII88_09955 ENOG4105CS1 NAD(P)H quinone oxidoreductase GII88_09970 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GII88_09975 ENOG4105WFK nuclease GII88_09980 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GII88_09990 ENOG4108SVB resolvase GII88_09995 ENOG4105VPS UPF0291 protein GII88_10000 ENOG4105CV1 Transketolase (EC 2.2.1.1) GII88_10010 ENOG4105VXM UPF0154 protein GII88_10020 ENOG4107QIV Cytochrome c biogenesis protein GII88_10045 ENOG41076DU acid-soluble spore protein P GII88_10055 ENOG4108I0Z Aconitate hydratase GII88_10060 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GII88_10085 ENOG4105MI2 GII88_10105 ENOG4105W8X HesB YadR YfhF-family protein GII88_10110 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GII88_10115 ENOG4105K4P CoA-binding domain protein GII88_10120 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GII88_10130 ENOG4105CMD Transcriptional regulator, GntR family GII88_10145 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) GII88_10150 ENOG4107QNK )-transporter GII88_10155 ENOG4105CHR reductase GII88_10180 ENOG4105R3A Nitrate reductase GII88_10185 ENOG4108IUE nitrate reductase beta subunit GII88_10220 ENOG4107V6Q Cyclic nucleotide-binding domain GII88_10240 ENOG4105DSQ Nitric oxide reductase GII88_10245 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GII88_10250 ENOG4106U2H Protein of unknown function (DUF1360) GII88_10265 ENOG4108428 Inherit from COG: -acetyltransferase GII88_10275 ENOG4105C3M thioredoxin reductase GII88_10290 ENOG4108M26 parallel beta-helix repeat protein GII88_10300 ENOG4105DQ4 alcohol dehydrogenase GII88_10305 ENOG4105VUF Transcriptional regulator GII88_10330 ENOG41060WC Enoyl-CoA hydratase GII88_10335 ENOG4105C26 Dehydrogenase GII88_10340 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GII88_10345 ENOG4105C1G acyl-Coa dehydrogenase GII88_10350 ENOG4105DG6 mannose-6-phosphate isomerase GII88_10355 ENOG4105DM4 PTS System GII88_10390 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GII88_10395 ENOG4105DMW Dehydrogenase reductase GII88_10400 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GII88_10410 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GII88_10415 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter GII88_10420 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GII88_10425 ENOG4107KJX Transcriptional regulator GII88_10430 ENOG4108UXE Protein tyrosine phosphatase GII88_10435 ENOG4107R5R arsenical pump membrane protein GII88_10440 ENOG41082YX Transcriptional regulator, arsr family GII88_10445 ENOG4105CZ9 Domain of unknown function (DU1801) GII88_10455 ENOG4105CSC Glucose uptake protein GII88_10460 ENOG4105F32 YngK protein GII88_10470 ENOG4105F1A Pyruvate formate-lyase GII88_10480 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family GII88_10510 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GII88_10515 ENOG4107QX3 carboxylase GII88_10520 ENOG4105E39 Enoyl-CoA hydratase GII88_10525 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GII88_10530 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GII88_10535 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GII88_10540 ENOG4105CEY Amp-dependent synthetase and ligase GII88_10545 ENOG4105C1G acyl-Coa dehydrogenase GII88_10550 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GII88_10555 ENOG4105KVH Transcriptional regulator GII88_10560 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GII88_10565 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GII88_10575 ENOG4105H67 Protein of unknown function (DUF421) GII88_10590 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GII88_10595 ENOG41061P3 phosphosulfolactate synthase GII88_10605 ENOG4105DIA mandelate racemase muconate lactonizing GII88_10610 ENOG4107RCC Major Facilitator Superfamily GII88_10630 ENOG4105BZ8 glutamate synthase GII88_10635 ENOG4105CBC glutamate synthase GII88_10640 ENOG4105C5Q Transcriptional regulator GII88_10670 ENOG4105BZ1 (ABC) transporter GII88_10685 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GII88_10695 ENOG4105C0R drug resistance transporter emrb qaca subfamily GII88_10700 ENOG4108J2R molybdopterin oxidoreductase GII88_10715 ENOG4108Q8B Spore germination protein GII88_10720 ENOG4108NHD germination protein GII88_10725 ENOG4108Q8B Spore germination protein GII88_10730 ENOG4108Q8B Spore germination protein GII88_10745 ENOG4105C8Q Methyl-accepting chemotaxis GII88_10750 ENOG4108Z7R Chaperone CsaA GII88_10755 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GII88_10765 ENOG4108RZE Tetr family transcriptional regulator GII88_10775 ENOG4105T9C HD domain GII88_10785 ENOG4105FVX GII88_10805 ENOG4108W8B Beta-lactamase domain protein GII88_10820 ENOG4105D29 Helix-turn-helix type 11 domain protein GII88_10830 ENOG4105KTU Transcriptional regulator, arsr family GII88_10845 ENOG4105CUB amino acid GII88_10855 ENOG4105C5E polysaccharide biosynthesis protein GII88_10870 ENOG4107T8Q Glycosyl transferase (Group 1 GII88_10875 ENOG4108SJC Membrane GII88_10890 ENOG4107RUZ Sss sodium solute transporter superfamily GII88_10895 ENOG41069ER domain protein GII88_10900 ENOG4105C9U ATP-dependent DNA helicase RecQ GII88_10920 ENOG4105UNS Pfam:DUF419 GII88_10990 ENOG4108NHD germination protein GII88_11005 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GII88_11020 ENOG4107S9D Alpha beta hydrolase GII88_11040 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GII88_11050 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GII88_11055 ENOG4105ST3 Transcriptional regulator GII88_11075 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GII88_11080 ENOG4105SCY DNAK suppressor GII88_11095 ENOG4105C26 Dehydrogenase GII88_11115 ENOG4105EWU Squalene--hopene cyclase GII88_11120 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GII88_11135 ENOG4105C8J )-transporter GII88_11140 ENOG4105C09 Bile acid GII88_11145 ENOG4105C7S Dehydrogenase GII88_11150 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GII88_11155 ENOG4107T89 von Willebrand factor, type A GII88_11160 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GII88_11170 ENOG4105K4H Nlp p60 protein GII88_11200 ENOG4105FR1 rard protein GII88_11210 ENOG4108YQE rare lipoprotein a GII88_11220 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GII88_11235 ENOG4105FBA Phospholipase Carboxylesterase GII88_11245 ENOG4105E1V na solute symporter GII88_11270 ENOG4108VXD carboxy-peptidase GII88_11275 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GII88_11280 ENOG4108PJD permease GII88_11295 ENOG4106Z5R GII88_11300 ENOG410841Q phosphoesterase PA-phosphatase related protein GII88_11315 ENOG4105VSD UPF0346 protein GII88_11335 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) GII88_11340 ENOG4108UV1 cellular component movement GII88_11380 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GII88_11410 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GII88_11430 ENOG4106ITI Glutaredoxin GII88_11440 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GII88_11445 ENOG4105DVF Cytosine-specific methyltransferase GII88_11455 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GII88_11465 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GII88_11470 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GII88_11555 ENOG4106J9J DNA polymerase GII88_11565 ENOG4106IVX GII88_11570 ENOG4106PTB DnaB-like helicase C terminal domain GII88_11580 ENOG41088HM GII88_11585 ENOG4106YR8 GII88_11615 ENOG4108R1E Serine threonine protein phosphatase 1 GII88_11655 ENOG4108J9Q DNA ligase GII88_11700 ENOG4105GJD protein, conserved in bacteria GII88_11715 ENOG4105C7H Helicase, RecD TraA family GII88_11760 ENOG4107D0N GII88_11775 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GII88_11850 ENOG4107NTZ GII88_11910 ENOG4108NE4 GII88_12125 ENOG4105E4C Lytic transglycosylase catalytic GII88_12130 ENOG4105E4C Lytic transglycosylase catalytic GII88_12135 ENOG4105E4C Lytic transglycosylase catalytic GII88_12155 ENOG41067D4 cell wall surface anchor family protein GII88_12160 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GII88_12210 ENOG4106ANW SMI1_KNR4 GII88_12215 ENOG4106ANW SMI1_KNR4 GII88_12220 ENOG4106ANW SMI1_KNR4 GII88_12225 ENOG4106BHF GII88_12245 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GII88_12250 ENOG4108TSC N-acetyltransferase GII88_12255 ENOG4107S4Y M20 DapE family protein YgeY GII88_12270 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GII88_12290 ENOG4105E0X reductase GII88_12310 ENOG4105BZU Histidine kinase GII88_12330 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) GII88_12335 ENOG41090WU lipolytic protein G-D-S-L family GII88_12340 ENOG4108KF3 Electron transport protein SCO1 SenC GII88_12355 ENOG4105C7B Threonine dehydratase GII88_12365 ENOG4108UT2 hemolysin iii GII88_12375 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GII88_12390 ENOG4107YX5 Pfam:DUF548 GII88_12400 ENOG4105C01 Dihydroxy-acid dehydratase GII88_12415 ENOG4108V06 Glutathione peroxidase GII88_12420 ENOG4105CKU formyltetrahydrofolate synthetase GII88_12425 ENOG4105CVG Homoserine O-transsuccinylase GII88_12430 ENOG4108QBV Monogalactosyldiacylglycerol synthase GII88_12470 ENOG41081VK Ribonuclease GII88_12490 ENOG410890F Dynamin family GII88_12505 ENOG41065KQ synthase GII88_12510 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GII88_12515 ENOG4105C2W permease GII88_12520 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GII88_12525 ENOG4105CTD carboxy-peptidase GII88_12530 ENOG4105DVT helicase GII88_12540 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GII88_12550 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) GII88_12555 ENOG4108UKS UPF0398 protein GII88_12565 ENOG4107X2U Inherit from COG: Exonuclease-like protein GII88_12570 ENOG4108I5C dEAD DEAH box helicase GII88_12625 ENOG4105BZ4 penicillin-binding protein GII88_12635 ENOG4105CSM endonuclease III GII88_12650 ENOG4105CHM Aminotransferase GII88_12660 ENOG4105YAC GII88_12665 ENOG4105DVT helicase GII88_12670 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GII88_12675 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GII88_12680 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GII88_12695 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GII88_12700 ENOG4105CPK Glycosyl transferase (Group 1 GII88_12705 ENOG4105FJR Lmbe family GII88_12710 ENOG4108Z5K methylglyoxal synthase GII88_12715 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GII88_12720 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GII88_12725 ENOG4108JYZ YitT family GII88_12745 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GII88_12760 ENOG4108SXZ UPF0302 protein GII88_12765 ENOG41068YB TPR repeat-containing protein GII88_12780 ENOG4105CIH Imidazole acetol-phosphate transaminase GII88_12785 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GII88_12790 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GII88_12800 ENOG4105DK0 Indole-3-glycerol phosphate synthase GII88_12805 ENOG4108I0Q anthranilate phosphoribosyltransferase GII88_12810 ENOG4105CRQ synthase (Component I) GII88_12815 ENOG4105KHN chorismate mutase GII88_12820 ENOG4105D49 3-dehydroquinate synthase GII88_12825 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GII88_12830 ENOG4105BZU Histidine kinase GII88_12835 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GII88_12840 ENOG4105EAH synthase GII88_12845 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GII88_12850 ENOG4105XXQ heptaprenyl diphosphate synthase component I GII88_12860 ENOG4105EUJ GTP cyclohydrolase i GII88_12865 ENOG4105K70 DNA-binding protein GII88_12870 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GII88_12890 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GII88_12895 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GII88_12900 ENOG41065D1 GII88_12905 ENOG4105S2F GII88_12920 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GII88_12925 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GII88_12930 ENOG4105CAT Cytidine monophosphate kinase GII88_12935 ENOG4105MSI germination protein ypeb GII88_12950 ENOG4105HDK L-asparaginase GII88_12955 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GII88_12970 ENOG4107RGJ metallophosphoesterase GII88_12985 ENOG4105I7S Abortive infection protein GII88_12990 ENOG4105C9U ATP-dependent DNA helicase RecQ GII88_12995 ENOG4105T7X GII88_13005 ENOG4108SAX Membrane GII88_13010 ENOG4108JQ1 Dehydrogenase GII88_13015 ENOG4105DR5 peptidase GII88_13045 ENOG4105US7 Histidine kinase GII88_13050 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GII88_13055 ENOG4105BZU Histidine kinase GII88_13060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GII88_13065 ENOG4105CRE cytochrome C GII88_13070 ENOG4107TWT Cytochrome c biogenesis protein GII88_13075 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GII88_13080 ENOG4105FE9 pseudouridine synthase GII88_13090 ENOG4108JIC nucleoside recognition domain protein GII88_13095 ENOG4105DZ1 carboxypeptidase GII88_13105 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GII88_13110 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GII88_13130 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GII88_13135 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GII88_13140 ENOG4108R6K riboflavin synthase, subunit alpha GII88_13145 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GII88_13155 ENOG4105MEW serine threonine protein phosphatase GII88_13160 ENOG4105MYT Heat shock protein GII88_13175 ENOG4107ZE5 PPIases accelerate the folding of proteins GII88_13180 ENOG4105PTM secreted protein GII88_13185 ENOG4105K7W phage-related replication protein GII88_13190 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GII88_13205 ENOG4105G6R Stage v sporulation protein ae GII88_13215 ENOG4105CZ3 stage V sporulation protein ad GII88_13220 ENOG41090VF Stage v sporulation protein ac GII88_13235 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GII88_13240 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GII88_13245 ENOG41082AN stage II sporulation protein GII88_13250 ENOG4105DZ1 carboxypeptidase GII88_13255 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) GII88_13260 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GII88_13265 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GII88_13275 ENOG4105I3K Ferric uptake regulator, Fur family GII88_13280 ENOG4105MZ9 stage II sporulation protein m GII88_13285 ENOG4105CK1 PTS System GII88_13305 ENOG4107YB6 acetyltransferase, (GNAT) family GII88_13315 ENOG4108YZ4 nudix hydrolase GII88_13325 ENOG4105PF9 Transcriptional regulator GII88_13335 ENOG4105CPC Aldo Keto reductase GII88_13355 ENOG4106HZJ GII88_13370 ENOG4105KAC Antibiotic biosynthesis monooxygenase GII88_13375 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold GII88_13385 ENOG4107RRN ABC transporter substrate-binding protein GII88_13390 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GII88_13395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GII88_13400 ENOG4108RZA ABC transporter GII88_13410 ENOG4107R73 Mate efflux family protein GII88_13425 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GII88_13435 ENOG4105E5W Transporter GII88_13440 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase GII88_13460 ENOG4105DA5 (ABC) transporter GII88_13480 ENOG4105K7W phage-related replication protein GII88_13490 ENOG4108IXY short-chain dehydrogenase reductase GII88_13495 ENOG41069FQ Metallo-beta-lactamase superfamily GII88_13500 ENOG4105II7 pyrroline-5-carboxylate reductase GII88_13510 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GII88_13520 ENOG4105WDJ 50S ribosomal protein L33 GII88_13525 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GII88_13530 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GII88_13550 ENOG4108TZY GntR Family Transcriptional Regulator GII88_13555 ENOG4105CS2 ec 3.2.1.21 GII88_13560 ENOG4105CK1 PTS System GII88_13565 ENOG4105VCP PTS System GII88_13570 ENOG4105VZJ PTS System GII88_13575 ENOG4105G6Z alkaline phosphatase GII88_13580 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GII88_13585 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GII88_13590 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GII88_13600 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) GII88_13605 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GII88_13610 ENOG4108HNZ carboxyl transferase GII88_13620 ENOG4108QEG Membrane GII88_13625 ENOG4105CDA abc transporter atp-binding protein GII88_13630 ENOG4105E5Q amino acid AbC transporter GII88_13635 ENOG4108HW3 (ABC) transporter GII88_13640 ENOG4108Y6J UPF0403 protein GII88_13645 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) GII88_13650 ENOG4105C7S Dehydrogenase GII88_13655 ENOG4105CPP Dehydrogenase, E1 component GII88_13670 ENOG4105CKM Branched-chain carboxylic acid kinase GII88_13675 ENOG4107RDP Dehydrogenase GII88_13685 ENOG4108JUB Transcriptional regulator GII88_13690 ENOG4106CCJ Protein of unknown function (DUF2627) GII88_13695 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GII88_13700 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GII88_13715 ENOG4105D7W serine acetyltransferase GII88_13725 ENOG4107QQR Sporulation GII88_13730 ENOG4105S1Z Stage IV sporulation protein B GII88_13735 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GII88_13740 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GII88_13745 ENOG4105DX0 Hemolysin A GII88_13750 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GII88_13755 ENOG4105CTB Polyprenyl synthetase GII88_13760 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GII88_13765 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GII88_13770 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GII88_13775 ENOG4105M7K Involved in the transcription termination process (By similarity) GII88_13780 ENOG4108ZSR alkaline shock protein GII88_13785 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GII88_13805 ENOG410644B Stage III sporulation protein af GII88_13815 ENOG4105KQ4 Stage iii sporulation protein ad GII88_13820 ENOG4108CQH stage III sporulation protein AC GII88_13825 ENOG4105KR5 Stage iii sporulation protein GII88_13830 ENOG4105CD2 stage iii sporulation protein aa GII88_13840 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GII88_13845 ENOG4105DC7 peptidase M24 GII88_13850 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GII88_13860 ENOG4105CBJ Metal-dependent enzyme GII88_13875 ENOG4105KST dependent repressor GII88_13880 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GII88_13885 ENOG4105WZW rhodanese family GII88_13895 ENOG4107SQ8 Glycine betaine GII88_13900 ENOG4108IJ7 Glycine betaine GII88_13905 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GII88_13915 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GII88_13920 ENOG4105C0D helicase GII88_13945 ENOG4105VFR signal peptidase GII88_13985 ENOG4106855 Competence protein GII88_14020 ENOG4105C5X domain protein GII88_14050 ENOG4105E0M Sulfatase GII88_14070 ENOG4107ZXI Rhomboid family GII88_14075 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GII88_14080 ENOG4105WDJ 50S ribosomal protein L33 GII88_14100 ENOG41068DG YceG-like family GII88_14105 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GII88_14110 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GII88_14115 ENOG4105E2Z phosphate ABC transporter (Permease GII88_14120 ENOG4105C8U phosphate abc transporter GII88_14125 ENOG4105CVA phosphate GII88_14130 ENOG4107RF6 penicillin-binding protein GII88_14140 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GII88_14145 ENOG4105SXS Protein of unknown function (DUF456) GII88_14160 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GII88_14165 ENOG41063Y9 GII88_14170 ENOG4108U5J '-nucleotidase GII88_14175 ENOG4105N80 Ferric uptake regulator, Fur family GII88_14180 ENOG4105FAV ABC, transporter GII88_14185 ENOG4105FDK ABC transporter GII88_14190 ENOG4108JYZ YitT family GII88_14195 ENOG41069ZM Protein of unknown function (DUF2624) GII88_14200 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GII88_14215 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GII88_14220 ENOG4105EGD dinuclear metal center protein, YbgI family GII88_14230 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GII88_14235 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GII88_14295 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GII88_14300 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GII88_14310 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GII88_14320 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GII88_14325 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GII88_14330 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) GII88_14340 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GII88_14345 ENOG4105KG3 cytidine deaminase GII88_14350 ENOG4107YR5 Diacylglycerol kinase GII88_14355 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GII88_14360 ENOG4105CTJ Metal Dependent Phosphohydrolase GII88_14365 ENOG4105C9A Phoh family GII88_14370 ENOG4105EI1 sporulation protein yqfd GII88_14375 ENOG41068P3 sporulation protein YqfC GII88_14385 ENOG4105DI5 UPF0365 protein GII88_14390 ENOG4105F7J membrane-bound serine protease GII88_14395 ENOG4105KTH gatB Yqey GII88_14400 ENOG4105VCC 30S ribosomal protein S21 GII88_14410 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GII88_14415 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GII88_14420 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GII88_14425 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GII88_14430 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GII88_14435 ENOG4105CFG Acts as a chaperone (By similarity) GII88_14440 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GII88_14445 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GII88_14450 ENOG4105CSA Coproporphyrinogen iii oxidase GII88_14455 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GII88_14465 ENOG4108ZRV stage ii sporulation protein p GII88_14480 ENOG4105TQK DNA polymerase iii, delta' subunit GII88_14490 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GII88_14495 ENOG4108UK2 deaminase GII88_14500 ENOG4105KQC Competence protein GII88_14510 ENOG4108D32 Methyltransferase GII88_14520 ENOG4108WF2 Metal Dependent Phosphohydrolase GII88_14525 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GII88_14530 ENOG410812S Rna-binding protein GII88_14535 ENOG4105E2X shikimate dehydrogenase GII88_14540 ENOG4105CQW ribosome biogenesis GTPase YqeH GII88_14545 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GII88_14560 ENOG4105Z7P Acetyltransferase (GNAT) family GII88_14565 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) GII88_14570 ENOG4108JB9 formate dehydrogenase GII88_14585 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GII88_14605 ENOG4108ZRV stage ii sporulation protein p GII88_14620 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GII88_14650 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GII88_14655 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) GII88_14665 ENOG4105EFI regulatoR GII88_14740 ENOG4105WH1 Two component transcriptional regulator luxr family GII88_14745 ENOG4105BZU Histidine kinase GII88_14750 ENOG4105XXY Thioredoxin GII88_14755 ENOG41087NI Sulfite exporter TauE/SafE GII88_14760 ENOG4105VFE sira family GII88_14765 ENOG4107TPS domain protein GII88_14770 ENOG4105VFE sira family GII88_14775 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GII88_14780 ENOG4105XTG Pfam:DUF156 GII88_14785 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GII88_14825 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GII88_14830 ENOG4105D52 delta-aminolevulinic acid dehydratase GII88_14835 ENOG41080HJ 6-phospho 3-hexuloisomerase GII88_14840 ENOG4108VA3 3-hexulose-6-phosphate synthase GII88_14845 ENOG4105KVH Transcriptional regulator GII88_14850 ENOG4105ECK Fatty Acid Desaturase GII88_14855 ENOG4108ZGX Histidine kinase GII88_14860 ENOG4108S01 response regulator GII88_14865 ENOG4105CAY ferredoxin--nadp reductase GII88_14870 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GII88_14875 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GII88_14880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GII88_14890 ENOG4108JQ7 (ABC) transporter GII88_14905 ENOG4108ZX5 transcriptional regulator GII88_14910 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GII88_14930 ENOG410635A Membrane GII88_14945 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GII88_14950 ENOG4108HKT sucrose-6-phosphate hydrolase GII88_14955 ENOG4105F3R pts system mannose fructose sorbose family iid GII88_14960 ENOG4105ETZ PTS System GII88_14965 ENOG4108IQ3 PTS system GII88_14970 ENOG4105YHU PTS system GII88_14975 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GII88_14985 ENOG4105WDR GII88_15000 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GII88_15005 ENOG4105CV8 reductase GII88_15010 ENOG4105F27 Major Facilitator GII88_15015 ENOG4105KVH Transcriptional regulator GII88_15020 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) GII88_15025 ENOG4105EXQ uroporphyrinogen iii synthase hem4 GII88_15035 ENOG4108V5C ABC transporter GII88_15040 ENOG4107RSM transcriptional regulator GII88_15045 ENOG4105D94 Major Facilitator Superfamily GII88_15055 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GII88_15060 ENOG41082JN Transcriptional regulator GII88_15065 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GII88_15095 ENOG4105C28 cystathionine GII88_15105 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GII88_15110 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GII88_15125 ENOG4107XRG penicillin-binding protein GII88_15130 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GII88_15140 ENOG4105CFP Peptidase U32 GII88_15145 ENOG4105XYU peptidase (U32 family) GII88_15150 ENOG4108VQJ O-methyltransferase GII88_15155 ENOG4105HHA aminodeoxychorismate lyase GII88_15160 ENOG4105VPH UPF0473 protein GII88_15165 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GII88_15170 ENOG4105VBH UPF0297 protein GII88_15175 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GII88_15180 ENOG4105C02 permease GII88_15190 ENOG41060CR GII88_15200 ENOG4105C7H Helicase, RecD TraA family GII88_15210 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GII88_15215 ENOG4105C3J Cysteine desulfurase GII88_15225 ENOG4105D1H recombination factor protein RarA GII88_15230 ENOG4105CUZ uba thif-type nad fad binding protein GII88_15240 ENOG4105C9M aspartyl-trna synthetase GII88_15245 ENOG4105CUT histidyl-tRNA synthetase GII88_15250 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GII88_15255 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GII88_15260 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GII88_15265 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GII88_15270 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GII88_15275 ENOG41067VP Protein of unknown function (DUF1049) GII88_15280 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GII88_15290 ENOG4105CKP Polysaccharide Biosynthesis Protein GII88_15295 ENOG4108QG2 Membrane GII88_15300 ENOG4105NAP GII88_15305 ENOG4105VIE preprotein translocase, subunit YajC GII88_15310 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GII88_15315 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GII88_15320 ENOG41061AI Protein of unknown function (DUF2905) GII88_15325 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GII88_15330 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GII88_15345 ENOG41069DP small acid-soluble spore protein GII88_15355 ENOG4105K7W phage-related replication protein GII88_15370 ENOG4105CDY transcriptional regulatory protein GII88_15380 ENOG4106678 morphogenetic protein associated with SpoVID GII88_15385 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GII88_15390 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GII88_15395 ENOG4108IYU L-aspartate oxidase GII88_15410 ENOG4105CQC Prephenate dehydratase GII88_15415 ENOG41090I5 UPF0735 ACT domain-containing protein GII88_15420 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GII88_15430 ENOG4105K46 50S ribosomal protein l27 GII88_15435 ENOG4105X36 (ribosomal) protein GII88_15440 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GII88_15460 ENOG41082BM Transcriptional regulator, arsr family GII88_15465 ENOG4107QMS site-determining protein GII88_15470 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GII88_15475 ENOG4105YHC Rod shape-determining protein MreD GII88_15480 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GII88_15485 ENOG4105DFF Rod shape-determining protein mreb GII88_15490 ENOG4105W5Q DNA repair protein (RadC GII88_15495 ENOG4108Z03 MAF-like protein GII88_15505 ENOG4106A3R peptidase GII88_15510 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GII88_15515 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GII88_15525 ENOG4106AR7 Spore coat protein GII88_15530 ENOG41068KH stage VI sporulation protein D GII88_15535 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GII88_15540 ENOG4105D52 delta-aminolevulinic acid dehydratase GII88_15550 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GII88_15560 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GII88_15570 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GII88_15575 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GII88_15580 ENOG4108IUQ atp-dependent protease GII88_15585 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GII88_15590 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GII88_15600 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GII88_15605 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GII88_15610 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GII88_15615 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GII88_15620 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GII88_15625 ENOG4108ZP8 Acetolactate synthase small subunit GII88_15630 ENOG4105C7K acetolactate synthase GII88_15635 ENOG4105CM2 brancheD-chain amino acid aminotransferase GII88_15645 ENOG4107R37 Glutamate dehydrogenase GII88_15665 ENOG4108MDF Phage Portal Protein GII88_15740 ENOG4105M59 Phosphodiesterase, mj0936 family GII88_15745 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GII88_15750 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GII88_15755 ENOG4108XJQ germination protein GII88_15760 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GII88_15765 ENOG41067TZ transcriptional regulator, MarR family GII88_15770 ENOG4105PFC Transcriptional regulator GII88_15775 ENOG4105EMU Dehydrogenase GII88_15785 ENOG4105E33 succinate dehydrogenase GII88_15795 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GII88_15805 ENOG4105CFH Aspartokinase GII88_15810 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GII88_15815 ENOG4105K63 Thioredoxin GII88_15820 ENOG4105C10 Electron transfer flavoprotein GII88_15825 ENOG4105BZJ Electron transfer flavoprotein GII88_15830 ENOG41060WC Enoyl-CoA hydratase GII88_15835 ENOG4107Z3H Transcriptional regulator, TetR family GII88_15840 ENOG4105CEY Amp-dependent synthetase and ligase GII88_15850 ENOG4105C98 muts2 protein GII88_15855 ENOG4105DCG PHP domain protein GII88_15865 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GII88_15870 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GII88_15895 ENOG4108IUZ ABC transporter GII88_15910 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GII88_15915 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GII88_15920 ENOG4108RWN rrna methyltransferase GII88_15925 ENOG41067MF small acid-soluble spore protein GII88_15945 ENOG4105DRS transport system, permease GII88_15960 ENOG4108MDK Dehydrogenase GII88_15965 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GII88_15970 ENOG4105EF1 ribulokinase GII88_15975 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) GII88_15980 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase GII88_15985 ENOG4105CN9 Peptidase m42 family protein GII88_15995 ENOG410696E Membrane GII88_16000 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GII88_16005 ENOG4105VJV 50s ribosomal protein L35 GII88_16010 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GII88_16015 ENOG41067MG lrgb family GII88_16025 ENOG4105DGI Alkaline phosphatase GII88_16030 ENOG4105DY9 regulatoR GII88_16035 ENOG4108HRK Histidine kinase GII88_16045 ENOG4105U0R haloacid dehalogenase-like hydrolase GII88_16050 ENOG4105C22 threonyL-tRNA synthetase GII88_16055 ENOG4108TDW sporulation protein YtxC GII88_16075 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GII88_16090 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GII88_16095 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GII88_16110 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GII88_16120 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GII88_16125 ENOG4105C2M dna polymerase I GII88_16130 ENOG4105BZU Histidine kinase GII88_16135 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GII88_16140 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GII88_16145 ENOG4108HMX isocitrate dehydrogenase (NADP) GII88_16150 ENOG4105BZN citrate synthase GII88_16155 ENOG4108VMM UPF0756 membrane protein GII88_16160 ENOG4108REF Sporulation integral membrane protein ytvi GII88_16165 ENOG4105FS0 cytoplasmic membrane protein GII88_16170 ENOG4105CA9 Pyruvate kinase GII88_16175 ENOG4105CTQ phosphohexokinase GII88_16180 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GII88_16190 ENOG4105C6K Malic enzyme GII88_16195 ENOG4105C0B DNA polymerase III (alpha subunit) GII88_16200 ENOG4105VV2 GII88_16210 ENOG4106EVM GII88_16215 ENOG4105SFS phosphoesterase RecJ domain protein GII88_16230 ENOG4105U3E Transcriptional regulator GII88_16235 ENOG4105E8R UPF0173 metal-dependent hydrolase GII88_16245 ENOG4105CH7 arginosuccinase GII88_16250 ENOG4105CDH Citrulline--aspartate ligase GII88_16255 ENOG4105EPU Molybdenum cofactor synthesis domain protein GII88_16260 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GII88_16270 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GII88_16275 ENOG4105KBJ sporulation protein ytfj GII88_16285 ENOG4105VK3 rdd domain containing protein GII88_16290 ENOG4105D07 Signal peptide peptidase, SppA GII88_16300 ENOG4105CW7 secretion protein, HlyD family GII88_16315 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GII88_16325 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GII88_16355 ENOG4105U5Y Transcriptional regulator GII88_16365 ENOG4105BZU Histidine kinase GII88_16370 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GII88_16385 ENOG4105KAF membrAne GII88_16390 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GII88_16400 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GII88_16410 ENOG4105F1V Acetoin utilization protein GII88_16415 ENOG4105W87 Cbs domain GII88_16420 ENOG4105DGU Histone deacetylase GII88_16425 ENOG4105ER2 Ompa motb domain protein GII88_16430 ENOG4107R0U MotA TolQ exbB proton channel GII88_16435 ENOG4105ETE Transcriptional regulator (LacI family GII88_16440 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GII88_16465 ENOG4105DFU Cell wall formation (By similarity) GII88_16475 ENOG4108VDD TRNA binding domain protein GII88_16490 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ GII88_16510 ENOG4105C6K Malic enzyme GII88_16515 ENOG4105C8F Beta-lactamase domain protein GII88_16520 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GII88_16530 ENOG4108V15 phosphotransferase enzyme family GII88_16535 ENOG4108IUM Glycogen debranching enzyme GII88_16550 ENOG4107F58 2'-5' rna ligase GII88_16555 ENOG4105C6T cysteine synthase GII88_16570 ENOG4107QSE Dipeptidase GII88_16575 ENOG4105C7N Xanthine uracil vitamin C permease GII88_16580 ENOG4105YW5 deoR family transcriptional regulator GII88_16595 ENOG4105CBX hi0933 family GII88_16600 ENOG4105C94 Transporter GII88_16610 ENOG41085GJ domain protein GII88_16625 ENOG4105MU9 integral membrane protein GII88_16630 ENOG4105DDC Oxidoreductase domain protein GII88_16640 ENOG4105F5H Glycosyl Hydrolase Family 88 GII88_16650 ENOG41075H3 AraC family transcriptional regulator GII88_16660 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GII88_16670 ENOG4105NTD Inherit from COG: Hydrolase GII88_16680 ENOG4107V2S Transcriptional regulator GII88_16685 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GII88_16690 ENOG4105C8T Leucyl-tRNA synthetase GII88_16700 ENOG410605W Major Facilitator GII88_16705 ENOG4105D01 (LipO)protein GII88_16710 ENOG4106UBQ GII88_16715 ENOG4107R34 abc transporter permease protein GII88_16720 ENOG4105C19 ABC transporter GII88_16730 ENOG4105DVE abc transporter atp-binding protein GII88_16735 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GII88_16745 ENOG4105N5T Radical SAM Protein GII88_16765 ENOG4105E8V Alpha Beta Hydrolase Fold protein GII88_16770 ENOG4108Z0R Transferase GII88_16775 ENOG4105YVM Phosphoesterase, PA-phosphatase related GII88_16780 ENOG4105BZF Glycosyl transferase (Group 1 GII88_16785 ENOG4105CAQ asparagine synthetase GII88_16790 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GII88_16815 ENOG4105D2X ABC transporter substrate-binding protein GII88_16825 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GII88_16845 ENOG4108RMU ferritin dps family protein GII88_16860 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GII88_16865 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GII88_16870 ENOG4108V2W Carbonate dehydratase GII88_16875 ENOG4105CKI cobalamin synthesis protein GII88_16880 ENOG4105DSE periplasmic solute binding protein GII88_16910 ENOG4105DTQ mandelate racemase muconate lactonizing GII88_16915 ENOG4105CEY Amp-dependent synthetase and ligase GII88_16920 ENOG4108IPT Naphthoate synthase GII88_16925 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GII88_16930 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GII88_16935 ENOG4105E4F Isochorismate synthase GII88_16940 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GII88_16965 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GII88_16970 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GII88_17090 ENOG4105CMD Transcriptional regulator, GntR family GII88_17095 ENOG4105N67 Proton-coupled thiamine transporter YuaJ GII88_17120 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GII88_17130 ENOG4105CZN Potassium uptake protein GII88_17140 ENOG4106DF1 GII88_17145 ENOG4108VNY MOSC domain protein GII88_17150 ENOG4108JB8 alcohol dehydrogenase GII88_17155 ENOG4105C26 Dehydrogenase GII88_17160 ENOG4105TRT Transcriptional regulator GII88_17170 ENOG4105JQZ Methyltransferase GII88_17175 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GII88_17180 ENOG4105F0F Oxalate decarboxylase GII88_17220 ENOG41065RQ ADP-ribosylation crystallin J1 GII88_17255 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) GII88_17280 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GII88_17290 ENOG4105EE0 oxidoreductase GII88_17295 ENOG4108Z0Z intracellular protease Pfpi family GII88_17300 ENOG4105C8Q Methyl-accepting chemotaxis GII88_17305 ENOG4105C8Q Methyl-accepting chemotaxis GII88_17310 ENOG4105C8Q Methyl-accepting chemotaxis GII88_17320 ENOG4105EA8 2-Nitropropane dioxygenase GII88_17325 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GII88_17350 ENOG4105C37 (CBS) domain GII88_17365 ENOG4107PBV potassium channel GII88_17370 ENOG4107PBV potassium channel GII88_17380 ENOG410900G Protein of unknown function (DUF421) GII88_17390 ENOG4105KNA -acetyltransferase GII88_17395 ENOG4107QYV phosphohexose isomerase GII88_17400 ENOG4107QW4 alcohol dehydrogenase GII88_17405 ENOG4105WG9 Conserved Protein GII88_17415 ENOG4105CHM Aminotransferase GII88_17420 ENOG4108ZB6 transcriptional regulator AsnC family GII88_17425 ENOG4108MUZ hydrolase GII88_17440 ENOG4105C87 Aminotransferase class I and II GII88_17450 ENOG4105Y38 Kinase-associated protein B GII88_17465 ENOG4105BZ4 penicillin-binding protein GII88_17470 ENOG4105KIR Thiol-disulfide oxidoreductase dcc GII88_17485 ENOG4108MRH transcriptional regulatory protein GII88_17495 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GII88_17500 ENOG4107ZTW SNARE associated Golgi GII88_17505 ENOG4105DJ4 phosphatidylserine decarboxylase GII88_17520 ENOG4105D65 subunit l GII88_17525 ENOG4105HC0 Na H antiporter GII88_17530 ENOG4108ZE9 Monovalent cation H antiporter subunit C GII88_17535 ENOG4108JPZ Monovalent cation H antiporter subunit D GII88_17540 ENOG4105SC1 monovalent cation H antiporter subunit E GII88_17550 ENOG4105KJM monovalent cation h antiporter subunit g GII88_17555 ENOG4105KA0 thioesterase Superfamily protein GII88_17565 ENOG4105BZU Histidine kinase GII88_17595 ENOG4105D58 Diguanylate phosphodiesterase GII88_17600 ENOG4105DAP Nicotinate phosphoribosyltransferase GII88_17625 ENOG4105C02 permease GII88_17630 ENOG4108Z40 Transcriptional regulator GII88_17650 ENOG410904N short-chain dehydrogenase reductase GII88_17685 ENOG4105BZG amino acid carrier protein GII88_17690 ENOG4108K8K Transcriptional regulator GII88_17695 ENOG4105DCF alanine dehydrogenase GII88_17720 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GII88_17730 ENOG41069ER domain protein GII88_17740 ENOG4105CEP NADH dehydrogenase GII88_17745 ENOG4105CAY ferredoxin--nadp reductase GII88_17760 ENOG4108YM7 Gcn5-related n-acetyltransferase GII88_17765 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GII88_17790 ENOG4108ZMX Domain of unknown function (DU1801) GII88_17805 ENOG4105PY6 Phenolic acid decarboxylase GII88_17820 ENOG41083MR nifu domain-containing protein GII88_17825 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GII88_17830 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GII88_17835 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GII88_17840 ENOG4105D6E homoserine dehydrogenase GII88_17845 ENOG4105C5I Dehydrogenase GII88_17855 ENOG4108W5N phosphatidylglycerophosphatase a GII88_17860 ENOG4105D4U had-superfamily hydrolase, subfamily iia GII88_17870 ENOG4105MMD transcriptional regulator GII88_17875 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GII88_17880 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GII88_17885 ENOG4105FAA peptidase M23 GII88_17895 ENOG4105C8J )-transporter GII88_17900 ENOG4108YTE sporulation protein YunB GII88_17905 ENOG4105KZD Domain of unknown function (DUF1805) GII88_17910 ENOG4107R8B 5'-nucleotidase GII88_17920 ENOG4105I3N Conserved Protein GII88_17925 ENOG4105IIP Membrane GII88_17930 ENOG4105W1N transcriptional regulator GII88_17940 ENOG4105C5R Aminotransferase GII88_17950 ENOG4105G9B Transcriptional regulator GII88_17965 ENOG4108I0Q anthranilate phosphoribosyltransferase GII88_17970 ENOG4108I0Q anthranilate phosphoribosyltransferase GII88_17975 ENOG4108K8S endonuclease I GII88_17985 ENOG4107VFR oxidoreductase GII88_18005 ENOG4105DIW FeS assembly protein SUFB GII88_18010 ENOG4108UNV SUF system FeS assembly protein, NifU family GII88_18015 ENOG4105C9B Cysteine desulfurase GII88_18020 ENOG4105JRK feS assembly protein SufD GII88_18025 ENOG4105C3K feS assembly ATPase SufC GII88_18030 ENOG4105PGM cation diffusion facilitator family transporter GII88_18040 ENOG4105D01 (LipO)protein GII88_18045 ENOG4108UMI ABC transporter, permease GII88_18050 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GII88_18075 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GII88_18080 ENOG41080E8 Transcriptional regulator, Spx MgsR family GII88_18085 ENOG4105C1G acyl-Coa dehydrogenase GII88_18090 ENOG4105CHU acetyl-coa acetyltransferase GII88_18125 ENOG4105E0A ABC, transporter GII88_18130 ENOG4108IHU transport system permease protein GII88_18135 ENOG4105DQ5 transport system permease protein GII88_18140 ENOG4108MES Periplasmic binding protein GII88_18155 ENOG4105DZ1 carboxypeptidase GII88_18160 ENOG4105E1F short-chain dehydrogenase reductase GII88_18165 ENOG4105HUF DNA protection during starvation protein GII88_18170 ENOG4105C0H protease GII88_18180 ENOG4105F3H Histidine kinase GII88_18185 ENOG41067SE Tetr family transcriptional regulator GII88_18190 ENOG4105C9Q fumarate hydratase class II GII88_18220 ENOG4105WH1 Two component transcriptional regulator luxr family GII88_18225 ENOG4105ENE Histidine kinase GII88_18240 ENOG41087YS Phage shock protein A GII88_18255 ENOG4108WBT adenosyltransferase GII88_18260 ENOG4105CHR reductase GII88_18275 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GII88_18280 ENOG4105E0A ABC, transporter GII88_18285 ENOG4105EHG Permease protein GII88_18290 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GII88_18295 ENOG4105DRR Transcriptional regulator, GntR family GII88_18300 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GII88_18305 ENOG4108RPX mosc domain containing protein GII88_18310 ENOG4105DND Transcriptional regulator GII88_18320 ENOG4105CTX dehydratase GII88_18325 ENOG4107QZW Altronate oxidoreductase GII88_18330 ENOG4107KJX Transcriptional regulator GII88_18335 ENOG4105CT4 transporter GII88_18340 ENOG4105D2H Uronic isomerase GII88_18350 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GII88_18355 ENOG4105E0A ABC, transporter GII88_18360 ENOG4105EHG Permease protein GII88_18365 ENOG4105DQ5 transport system permease protein GII88_18370 ENOG4105D5Q Arginine ornithine antiporter GII88_18380 ENOG4107K5X Membrane-bound metal-dependent hydrolase GII88_18385 ENOG4107QZ2 Sulfatase GII88_18400 ENOG4105EVU fructokinase GII88_18405 ENOG4107EPV Aminotransferase class V GII88_18415 ENOG4105EEM helicase GII88_18420 ENOG4105EN6 Membrane GII88_18425 ENOG4105RHY Pfam:UPF0157 GII88_18430 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GII88_18440 ENOG4107ZQN disulfide bond GII88_18445 ENOG4105C59 p-type ATPase GII88_18450 ENOG4108JE9 extracellular solute-binding protein family 1 GII88_18455 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GII88_18460 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GII88_18465 ENOG4105CJQ hydrolase, family 31 GII88_18475 ENOG4105DIK (ABC) transporter GII88_18480 ENOG4105CC5 ABC transporter GII88_18485 ENOG4105DSE periplasmic solute binding protein GII88_18495 ENOG4105HX0 Transcriptional regulator GII88_18500 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GII88_18505 ENOG4105DM4 PTS System GII88_18520 ENOG4105C59 p-type ATPase GII88_18525 ENOG410681U heavy metal transport detoxification protein GII88_18530 ENOG4105VPX protein, conserved in bacteria GII88_18535 ENOG4107RKG DJ-1/PfpI family GII88_18540 ENOG4105E98 transcriptional regulator DeoR family GII88_18545 ENOG4105DET Rhamnulokinase GII88_18550 ENOG4105C9F isomerase GII88_18565 ENOG4105F27 Major Facilitator GII88_18575 ENOG410625E GII88_18580 ENOG4106A3M Cytochrome p-450 GII88_18600 ENOG4105D9R oxidoreductase GII88_18610 ENOG4105C72 UPF0176 protein GII88_18620 ENOG4106DF4 Sigma-70, region 4 GII88_18630 ENOG4105F0F Oxalate decarboxylase GII88_18660 ENOG4107EV6 Inherit from COG: YD repeat protein GII88_18675 ENOG4108QY0 Membrane GII88_18685 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein GII88_18715 ENOG41068G1 GII88_18725 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GII88_18735 ENOG4108FKH Transglycosylase SLT domain GII88_18780 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GII88_18795 ENOG4105CAR Terminase, large subunit GII88_18930 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GII88_18935 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GII88_18945 ENOG4105XZU Preprotein translocase, subunit SecG GII88_18970 ENOG4105R40 Glycine betaine carnitine choline GII88_18975 ENOG4108HQR Glycine betaine GII88_18980 ENOG4105E90 ABC transporter GII88_18985 ENOG4108IJ8 ABC transporter GII88_18990 ENOG4107HG4 Transcriptional regulator GII88_18995 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GII88_19005 ENOG4105T65 Membrane-associated protein GII88_19015 ENOG4108MES Periplasmic binding protein GII88_19025 ENOG4108V4B ThiJ pfpI GII88_19030 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GII88_19035 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GII88_19040 ENOG4105CP7 Triose-phosphate isomerase GII88_19045 ENOG4105BZA Phosphoglycerate kinase GII88_19050 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GII88_19060 ENOG4105DEN Luciferase family GII88_19075 ENOG4105CIG ABC transporter GII88_19095 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GII88_19100 ENOG4105JXH GntR family transcriptional regulator GII88_19105 ENOG4105DAA L-lactate GII88_19110 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GII88_19120 ENOG4108ZPC Polysaccharide pyruvyl transferase GII88_19125 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GII88_19130 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family GII88_19135 ENOG4105D3Q Sugar transferase GII88_19145 ENOG4105K64 Glycosyl transferase, family 2 GII88_19155 ENOG4107QRS glycosyltransferase group 2 family protein GII88_19160 ENOG41068W6 Capsular polysaccharide biosynthesis protein GII88_19165 ENOG4108KMV Glycosyl transferase (Group 1 GII88_19170 ENOG4105K64 Glycosyl transferase, family 2 GII88_19175 ENOG4108PQP glycosyl transferase group 1 GII88_19185 ENOG4108QV3 biosynthesis protein GII88_19190 ENOG4105HTX biosynthesis protein GII88_19200 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GII88_19205 ENOG4108I5G Major Facilitator superfamily GII88_19215 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GII88_19220 ENOG4107S2N Type III effector Hrp-dependent GII88_19230 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GII88_19245 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GII88_19250 ENOG4105EDQ levansucrase EC 2.4.1.10 GII88_19255 ENOG4108HKT sucrose-6-phosphate hydrolase GII88_19270 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GII88_19275 ENOG4108URH decarboxylase GII88_19280 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain GII88_19285 ENOG4107TVP HD domain protein GII88_19290 ENOG4105CHH sulfate transporter GII88_19295 ENOG4108V2W Carbonate dehydratase GII88_19300 ENOG4105C5I Dehydrogenase GII88_19310 ENOG4108ZHR arsR family transcriptional regulator GII88_19325 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GII88_19330 ENOG4105KRI phosphocarrier protein (HPr GII88_19335 ENOG4105CIE May be required for sporulation (By similarity) GII88_19340 ENOG4105CHW UPF0052 protein GII88_19345 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GII88_19350 ENOG4108Z4K mutator MutT protein GII88_19360 ENOG4105C3M thioredoxin reductase GII88_19375 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GII88_19380 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GII88_19385 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GII88_19390 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GII88_19395 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GII88_19400 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GII88_19405 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GII88_19410 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) GII88_19420 ENOG4108E16 pectate lyase GII88_19425 ENOG4108S4C acetyltransferase GII88_19430 ENOG4107XGZ Hydrolase GII88_19435 ENOG4105HKU nucleoside recognition domain-containing protein GII88_19445 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GII88_19450 ENOG410834F Transcriptional regulator GII88_19455 ENOG4105C0R drug resistance transporter emrb qaca subfamily GII88_19460 ENOG41088CQ domain protein GII88_19465 ENOG41086DT Membrane protein of unknown function GII88_19470 ENOG41067S9 phage shock protein C, PspC GII88_19475 ENOG4108PY7 GII88_19490 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GII88_19500 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GII88_19505 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GII88_19530 ENOG4105CN1 protease GII88_19535 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GII88_19545 ENOG4105CRP Part of the ABC transporter FtsEX involved in GII88_19550 ENOG4105CAK Cell division ATP-binding protein ftsE GII88_19570 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GII88_19575 ENOG4105MS2 ribosomal subunit Interface protein GII88_19590 ENOG4105MQ3 flagellar protein FliS GII88_19595 ENOG4107RT6 flagellar hook-associated GII88_19600 ENOG41083S7 flagellar protein FlaG GII88_19605 ENOG4105I03 Flagellin GII88_19610 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GII88_19615 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) GII88_19620 ENOG4105MKD GII88_19625 ENOG4105DTJ flagellar hook-associated protein GII88_19630 ENOG4105E1Q flagellar hook-associated protein GII88_19645 ENOG4105RU3 GII88_19650 ENOG41081UC Inherit from COG: Competence protein GII88_19670 ENOG4105WH1 Two component transcriptional regulator luxr family GII88_19675 ENOG4105BZU Histidine kinase GII88_19680 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GII88_19685 ENOG4108KGH TRANSCRIPTIONal GII88_19695 ENOG4105ESV Glycosyl transferase, family 4 GII88_19700 ENOG4107EF8 Glycosyl transferase (Group 1 GII88_19715 ENOG4105QZI O-Antigen Polymerase GII88_19720 ENOG4105C1B dTDP-glucose 4-6-dehydratase GII88_19725 ENOG4105C6Y Udp-glucose 6-dehydrogenase GII88_19730 ENOG4107RA4 Glycosyl transferase (Group 1 GII88_19735 ENOG4105PSV Polysaccharide Biosynthesis Protein GII88_19740 ENOG4105D3Q Sugar transferase GII88_19745 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GII88_19750 ENOG4105JFG SpoIID LytB domain protein GII88_19760 ENOG4108KGH TRANSCRIPTIONal GII88_19765 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GII88_19775 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GII88_19780 ENOG4105EY8 ABC transporter GII88_19790 ENOG4107SJB teichoic acid biosynthesis GII88_19795 ENOG4107SJB teichoic acid biosynthesis GII88_19800 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase GII88_19810 ENOG4107RZX Teichoic acid biosynthesis protein GII88_19820 ENOG4105DG6 mannose-6-phosphate isomerase GII88_19830 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GII88_19835 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) GII88_19840 ENOG4108UHU Aldolase GII88_19845 ENOG4105D7K pfkb domain protein GII88_19850 ENOG4108M60 Transcriptional regulator GII88_19860 ENOG4105CHR reductase GII88_19865 ENOG4105E2A Dehydrogenase GII88_19870 ENOG4105C54 Major Facilitator superfamily GII88_19875 ENOG4108KGH TRANSCRIPTIONal GII88_19880 ENOG4105J7I hydrolase GII88_19885 ENOG4105K4H Nlp p60 protein GII88_19890 ENOG4105PNM synthesis protein GII88_19900 ENOG4105N98 Capsule biosynthesis protein capB GII88_19905 ENOG4105ETE Transcriptional regulator (LacI family GII88_19910 ENOG4108RVA ribokinase GII88_19915 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GII88_19920 ENOG4105C2J ABC transporter GII88_19925 ENOG4105CNN ABC, transporter GII88_19930 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GII88_19940 ENOG4107FQX Alpha-acetolactate decarboxylase GII88_19950 ENOG4107RSM transcriptional regulator GII88_19960 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GII88_19970 ENOG4105CAH Chromate GII88_19975 ENOG4105FGV Chromate GII88_19980 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GII88_19985 ENOG4105HTX biosynthesis protein GII88_19995 ENOG4105KBK Zinc finger, swim domain protein GII88_20000 ENOG4105C0D helicase GII88_20005 ENOG410667J hydrolase GII88_20010 ENOG4105E98 transcriptional regulator DeoR family GII88_20020 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase GII88_20025 ENOG4105VI0 Pts system, glucitol sorbitol-specific GII88_20030 ENOG4105DZY Pts system, glucitol sorbitol-specific GII88_20035 ENOG410787A Pts system, glucitol sorbitol-specific GII88_20045 ENOG4105DKT Transcriptional regulator GII88_20050 ENOG4105Z8H single-stranded DNA-binding protein GII88_20070 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GII88_20075 ENOG4105CGA flagellar basal-body rod protein FlgG GII88_20085 ENOG4105DFF Rod shape-determining protein mreb GII88_20090 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GII88_20100 ENOG4107MII Sugar-specific transcriptional regulator TrmB GII88_20105 ENOG4105CZM Major Facilitator GII88_20110 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GII88_20115 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GII88_20125 ENOG4108NA0 Uncharacterized conserved protein (COG2071) GII88_20130 ENOG41080XP Cbs domain GII88_20140 ENOG4105C37 (CBS) domain GII88_20145 ENOG4105BZU Histidine kinase GII88_20165 ENOG4105FRN stage II sporulation protein GII88_20170 ENOG4107TCE N-acetyltransferase GII88_20180 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GII88_20190 ENOG4105C0R drug resistance transporter emrb qaca subfamily GII88_20195 ENOG4105WQT MbtH domain protein GII88_20200 ENOG4105CEY Amp-dependent synthetase and ligase GII88_20205 ENOG4105WQI isochorismatase GII88_20210 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GII88_20215 ENOG4105E4F Isochorismate synthase GII88_20220 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GII88_20225 ENOG4105NIV Esterase GII88_20245 ENOG410874W AraC family transcriptional regulator GII88_20255 ENOG4108RYK Nad-dependent epimerase dehydratase GII88_20260 ENOG4108Z40 Transcriptional regulator GII88_20275 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GII88_20280 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GII88_20285 ENOG4105FCD Major Facilitator GII88_20290 ENOG4108HIZ formate dehydrogenase alpha subunit GII88_20295 ENOG4108TF4 von Willebrand factor, type A GII88_20310 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GII88_20320 ENOG4106778 Protein of unknown function (DUF1146) GII88_20325 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GII88_20330 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GII88_20335 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GII88_20340 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GII88_20345 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GII88_20360 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GII88_20375 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GII88_20380 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GII88_20385 ENOG4108UIC UPF0340 protein GII88_20390 ENOG4108YZG isomerase GII88_20395 ENOG4107WAU Protein tyrosine phosphatase GII88_20400 ENOG410815N Probably functions as a manganese efflux pump (By similarity) GII88_20405 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GII88_20415 ENOG4108ZXQ stage ii sporulation protein r GII88_20430 ENOG4105TRI Hydrolase GII88_20445 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GII88_20450 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GII88_20455 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GII88_20465 ENOG4107TT2 Auxin Efflux Carrier GII88_20470 ENOG4105C6K Malic enzyme GII88_20475 ENOG4107104 thymidine kinase GII88_20480 ENOG41082DI 50s ribosomal protein l31 GII88_20485 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GII88_20490 ENOG4105CBT Fructose-1,6-bisphosphatase GII88_20495 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GII88_20500 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway GII88_20505 ENOG4105D2N Aldolase GII88_20510 ENOG410812K response regulator receiver protein GII88_20520 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GII88_20530 ENOG4105C1G acyl-Coa dehydrogenase GII88_20535 ENOG4105C1G acyl-Coa dehydrogenase GII88_20540 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GII88_20550 ENOG4105DF6 Fe-S oxidoreductase GII88_20570 ENOG4105C75 arginyL-tRNA synthetase GII88_20575 ENOG410684U Domain of unknown function (DUF1934) GII88_20580 ENOG4105CYW agmatinase GII88_20585 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GII88_20600 ENOG4105BZ4 penicillin-binding protein GII88_20605 ENOG4108XFG YwhD family GII88_20610 ENOG4108Z4T Peptidase M50 GII88_20615 ENOG41069HH 4-oxalocrotonate tautomerase GII88_20630 ENOG4105DCI Phosphohydrolase GII88_20640 ENOG4108VCI transcription factor, rsfa family GII88_20650 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GII88_20660 ENOG4105D2S major facilitator superfamily GII88_20685 ENOG4108FUF Transcriptional regulator, IclR family GII88_20695 ENOG4108IJ2 phosphate acetyltransferase GII88_20700 ENOG4107JTW chlorite dismutase GII88_20715 ENOG4105CZN Potassium uptake protein GII88_20735 ENOG4105CJ1 ABC, transporter GII88_20765 ENOG4105C26 Dehydrogenase GII88_20770 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GII88_20775 ENOG4108RJ9 Glycosyl transferase, family 2 GII88_20780 ENOG4105DWF phosphomethylpyrimidine kinase GII88_20795 ENOG4105C5Y PTS System GII88_20810 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GII88_20820 ENOG4105DEN Luciferase family GII88_20825 ENOG4108DBC nitroreductase GII88_20845 ENOG4105DWD nucleoside recognition domain protein GII88_20900 ENOG41060D1 Quinol oxidase GII88_20910 ENOG4105BZ9 Cytochrome C oxidase, subunit I GII88_20915 ENOG4105E2S oxidase) subunit II GII88_20920 ENOG4105CMR udp-glucose 4-epimerase GII88_20950 ENOG4105CMG Carbohydrate kinase GII88_20955 ENOG4105C93 Xylose Isomerase GII88_20965 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GII88_20970 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GII88_20975 ENOG4105CMU LysR family (Transcriptional regulator GII88_20995 ENOG41067MG lrgb family GII88_21005 ENOG4105CK7 Sodium proline symporter GII88_21010 ENOG4105DR4 Methyltransferase GII88_21020 ENOG4105C5I Dehydrogenase GII88_21025 ENOG4105X1N Glycosyl transferase family 8 GII88_21035 ENOG4105ENE Histidine kinase GII88_21040 ENOG4108VB1 regulatoR GII88_21045 ENOG4105EYF MMPL domain protein GII88_21055 ENOG4105DJB Major Facilitator Superfamily GII88_21060 ENOG4105CXK mandelate racemase muconate lactonizing GII88_21065 ENOG4108UHU Aldolase GII88_21070 ENOG4105D7K pfkb domain protein GII88_21080 ENOG4105IIU Aminopeptidase GII88_21085 ENOG41080V3 Major Facilitator superfamily GII88_21110 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) GII88_21115 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GII88_21120 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) GII88_21125 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GII88_21130 ENOG4105CM2 brancheD-chain amino acid aminotransferase GII88_21140 ENOG4105F8D glycoside hydrolase family 4 GII88_21145 ENOG4105VCP PTS System GII88_21150 ENOG4105CK1 PTS System GII88_21155 ENOG4105VZJ PTS System GII88_21160 ENOG4105EMD TRANSCRIPTIONal GII88_21165 ENOG4108VX5 3-methyladenine DNA glycosylase GII88_21180 ENOG4105DXD 2-methylcitrate dehydratase GII88_21185 ENOG4105CR4 methylisocitrate lyase GII88_21200 ENOG4105BZ1 (ABC) transporter GII88_21205 ENOG4107TDE lipolytic protein G-D-S-L family GII88_21220 ENOG4105C2C drug resistance transporter, Bcr CflA GII88_21230 ENOG4105DA5 (ABC) transporter GII88_21235 ENOG41069JR GII88_21260 ENOG4105CH6 catalase GII88_21270 ENOG4105G5W regulator Fur family GII88_21275 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GII88_21280 ENOG4108TU7 Inherit from COG: (ABC) transporter GII88_21285 ENOG4105CJ1 ABC, transporter GII88_21300 ENOG4105CJ1 ABC, transporter GII88_21350 ENOG4108J20 pectate lyase GII88_21355 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GII88_21360 ENOG4108JJ8 (ABC) transporter GII88_21365 ENOG4108JJ9 ABC, transporter GII88_21370 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GII88_21375 ENOG4105C4M (Ubiquinol oxidase) subunit I GII88_21385 ENOG4108QTI )-transporter GII88_21400 ENOG4105DFD Na H antiporter GII88_21405 ENOG4108IJ0 Aspartate ammonia-lyase GII88_21410 ENOG4105HDK L-asparaginase GII88_21415 ENOG4108IMY Transcriptional regulator GII88_21420 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GII88_21460 ENOG4107BJW polysaccharide deacetylase GII88_21465 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GII88_21475 ENOG4105D2K citrate carrier protein GII88_21480 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GII88_21485 ENOG4105X3H Excalibur domain protein GII88_21495 ENOG4105E0M Sulfatase GII88_21505 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GII88_21520 ENOG4105CEU Arginine dihydrolase GII88_21525 ENOG4105DBV ornithine carbamoyltransferase GII88_21535 ENOG4105C5B carbamate kinase GII88_21550 ENOG4105CK1 PTS System GII88_21560 ENOG4105JVQ RNA Polymerase GII88_21585 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GII88_21590 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GII88_21600 ENOG4107R3K hydrolase GII88_21605 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GII88_21610 ENOG4105ETE Transcriptional regulator (LacI family GII88_21630 ENOG4105EDW glycosyl transferase, family 39 GII88_21635 ENOG4105CKK Glycosyl transferase, family 2 GII88_21640 ENOG4105CMR udp-glucose 4-epimerase GII88_21680 ENOG4105CS2 ec 3.2.1.21 GII88_21685 ENOG4105C5Y PTS System GII88_21690 ENOG4105CID antiterminator GII88_21695 ENOG4108W7F transporter, permease GII88_21700 ENOG4108JJB ABC transporter GII88_21705 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein GII88_21710 ENOG4105ETU transcriptional activator (TenA GII88_21720 ENOG4107QP3 malate synthase g GII88_21730 ENOG4105EDW glycosyl transferase, family 39 GII88_21740 ENOG4105C19 ABC transporter GII88_21745 ENOG4105EWM Histidine kinase GII88_21755 ENOG4105CS2 ec 3.2.1.21 GII88_21760 ENOG4105C5Y PTS System GII88_21770 ENOG4107QHE Choloylglycine hydrolase GII88_21775 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GII88_21780 ENOG4106Z5D Glycoside Hydrolase Family 43 GII88_21785 ENOG4105C1J atp-dependent rna helicase GII88_21815 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GII88_21820 ENOG4105D9N nucleoside GII88_21825 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GII88_21830 ENOG4107RHR regulatoR GII88_21850 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) GII88_21855 ENOG4107R8N Glycosyl transferase, family 2 GII88_21865 ENOG4105JKW Valine--pyruvate aminotransferase GII88_21890 ENOG4105D2N Aldolase GII88_21895 ENOG4107TRN Xylose isomerase domain protein TIM barrel GII88_21900 ENOG4105F0H myo-inositol catabolism protein GII88_21905 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GII88_21915 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GII88_21920 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GII88_21925 ENOG4105D7K pfkb domain protein GII88_21930 ENOG4105DH8 myo-inositol catabolism GII88_21935 ENOG4105C26 Dehydrogenase GII88_21945 ENOG4105CPC Aldo Keto reductase GII88_21950 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GII88_21955 ENOG4105CXY transporter GII88_21960 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GII88_21965 ENOG4105C5H ABC transporter GII88_21980 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) GII88_21990 ENOG4108V5C ABC transporter GII88_22020 ENOG4105H93 Acyltransferase family GII88_22050 ENOG4105EC8 Methyl-accepting chemotaxis GII88_22055 ENOG4105BZG amino acid carrier protein GII88_22060 ENOG4105DCF alanine dehydrogenase GII88_22075 ENOG4105EG2 ABC transporter, permease GII88_22085 ENOG4107FKK extracellular solute-binding protein family 1 GII88_22095 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GII88_22100 ENOG4105CMR udp-glucose 4-epimerase GII88_22105 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase GII88_22110 ENOG4105E2R ROK family GII88_22120 ENOG4105CMG Carbohydrate kinase GII88_22135 ENOG4108EKI Dehydrogenase GII88_22140 ENOG4105D3R alkyl hydroperoxide reductase GII88_22145 ENOG4108JU3 Alkyl hydroperoxide reductase GII88_22170 ENOG4108M15 ABC transporter GII88_22175 ENOG4105KCT ABC transporter GII88_22210 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GII88_22225 ENOG4105WQG acetyltransferase GII88_22240 ENOG4105C0H protease GII88_22245 ENOG4105Q2H domain protein GII88_22260 ENOG4105BZU Histidine kinase GII88_22265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GII88_22295 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GII88_22305 ENOG4105CDU Replicative dna helicase GII88_22325 ENOG4105DJ2 Major Facilitator Superfamily GII88_22330 ENOG4105CE4 GlcNAc 6-P deacetylase GII88_22335 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GII88_22340 ENOG4105FDP GntR family transcriptional regulator GII88_22345 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GII88_22355 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GII88_22360 ENOG4105BZR domain protein GII88_22365 ENOG4108XMW Membrane GII88_22375 ENOG4107YZX Universal stress protein GII88_22380 ENOG4105CHH sulfate transporter GII88_22390 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GII88_22395 ENOG4108UUM single-stranded DNA-binding protein GII88_22400 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GII88_22405 ENOG4105C3G gtp-binding protein GII88_22415 ENOG4105VDK protein, conserved in bacteria GII88_22425 ENOG4108ZDA Sporulation protein YyaC GII88_22430 ENOG4105FA0 parb-like partition protein GII88_22435 ENOG4107QJE Chromosome Partitioning Protein GII88_22440 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GII88_22450 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) GII88_22460 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GII88_22465 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GII88_22480 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)