locus-tag	class	description
GII88_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GII88_00010	COG0592	DNA-directed DNA polymerase activity
GII88_00015	COG2501	S4 domain
GII88_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GII88_00030	COG0187	DNA topoisomerase II activity
GII88_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GII88_00070	COG0516	GMP reductase activity
GII88_00070	COG0517	IMP dehydrogenase activity
GII88_00075	COG1686	Belongs to the peptidase S11 family
GII88_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GII88_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GII88_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GII88_00100	COG1929	Belongs to the glycerate kinase type-1 family
GII88_00105	COG2610	gluconate transmembrane transporter activity
GII88_00110	COG3835	regulator
GII88_00125	COG1428	Deoxynucleoside kinase
GII88_00130	COG1428	Deoxynucleoside kinase
GII88_00135	COG1388	LysM domain
GII88_00135	COG3858	chitin binding
GII88_00140	COG1335	isochorismatase
GII88_00145	COG0590	tRNA wobble adenosine to inosine editing
GII88_00155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GII88_00160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GII88_00165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GII88_00210	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GII88_00215	COG3853	Toxic anion resistance protein (TelA)
GII88_00220	COG1982	Orn Lys Arg decarboxylase major
GII88_00225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GII88_00230	COG3870	Protein conserved in bacteria
GII88_00235	COG1728	Protein conserved in bacteria
GII88_00240	COG0470	DNA polymerase III
GII88_00245	COG1774	PSP1 C-terminal conserved region
GII88_00250	COG4467	Involved in initiation control of chromosome replication
GII88_00255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GII88_00260	COG2827	Endonuclease containing a URI domain
GII88_00265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GII88_00270	COG2002	toxin-antitoxin pair type II binding
GII88_00275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII88_00275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII88_00280	COG0084	hydrolase, TatD family'
GII88_00285	COG3584	3D domain protein
GII88_00285	COG3583	domain protein
GII88_00290	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GII88_00295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GII88_00305	COG4466	Protein conserved in bacteria
GII88_00315	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GII88_00320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GII88_00325	COG0251	oxidation-reduction process
GII88_00330	COG2088	sporulation resulting in formation of a cellular spore
GII88_00335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GII88_00340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GII88_00345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GII88_00350	COG0193	aminoacyl-tRNA hydrolase activity
GII88_00360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GII88_00365	COG2002	toxin-antitoxin pair type II binding
GII88_00370	COG2244	polysaccharide biosynthetic process
GII88_00375	COG3956	TIGRFAM MazG family protein
GII88_00380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GII88_00395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GII88_00400	COG1098	S1 RNA binding domain
GII88_00415	COG2208	phosphoserine phosphatase activity
GII88_00420	COG2304	oxidoreductase activity
GII88_00425	COG0515	serine threonine protein kinase
GII88_00430	COG0037	tRNA processing
GII88_00440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GII88_00445	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GII88_00450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GII88_00455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GII88_00460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GII88_00470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GII88_00475	COG0512	Glutamine amidotransferase of anthranilate synthase
GII88_00480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GII88_00485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GII88_00490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GII88_00495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GII88_00500	COG1396	sequence-specific DNA binding
GII88_00505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GII88_00510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GII88_00590	COG4463	regulation of RNA biosynthetic process
GII88_00595	COG3880	PFAM UvrB UvrC protein
GII88_00600	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GII88_00605	COG0542	response to heat
GII88_00610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GII88_00615	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GII88_00620	COG4956	integral membrane protein (PIN domain superfamily)
GII88_00625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GII88_00630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GII88_00635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GII88_00640	COG1045	serine acetyltransferase
GII88_00645	COG0215	cysteine-tRNA ligase activity
GII88_00650	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GII88_00655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GII88_00660	COG3688	RNA-binding protein containing a PIN domain
GII88_00670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GII88_00680	COG0250	Participates in transcription elongation, termination and antitermination
GII88_00685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GII88_00690	COG0081	regulation of translation
GII88_00695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GII88_00700	COG0222	ribosome binding
GII88_00705	COG2813	Specifically methylates the guanine in position
GII88_00710	COG0085	RNA polymerase activity
GII88_00715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GII88_00720	COG1358	cellular component organization or biogenesis
GII88_00725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GII88_00730	COG0049	tRNA binding
GII88_00735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GII88_00740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GII88_00745	COG0051	transcription antitermination factor activity, RNA binding
GII88_00750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GII88_00755	COG0088	Forms part of the polypeptide exit tunnel
GII88_00760	COG0089	rRNA binding
GII88_00765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GII88_00770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GII88_00775	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GII88_00780	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GII88_00785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GII88_00790	COG0255	Belongs to the universal ribosomal protein uL29 family
GII88_00795	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GII88_00800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GII88_00805	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GII88_00810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GII88_00815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GII88_00820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GII88_00825	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GII88_00830	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GII88_00835	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GII88_00840	COG1841	ribosomal large subunit assembly
GII88_00845	COG0200	Binds to the 23S rRNA
GII88_00850	COG0201	protein transport
GII88_00855	COG0563	adenylate kinase activity
GII88_00860	COG0024	Methionine aminopeptidase
GII88_00865	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GII88_00870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GII88_00875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GII88_00880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GII88_00885	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GII88_00890	COG0202	RNA polymerase activity
GII88_00895	COG0203	ribosomal protein L17
GII88_00900	COG1122	ATPase activity
GII88_00905	COG1122	ATPase activity
GII88_00910	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GII88_00915	COG0101	tRNA pseudouridine synthase activity
GII88_00920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GII88_00925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GII88_00930	COG2318	DinB family
GII88_00940	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII88_00945	COG0489	protein tyrosine kinase activity
GII88_00955	COG2194	sulfuric ester hydrolase activity
GII88_00960	COG0726	polysaccharide deacetylase
GII88_00990	COG4974	Belongs to the 'phage' integrase family
GII88_00995	COG2856	Zn peptidase
GII88_01005	COG1396	sequence-specific DNA binding
GII88_01075	COG0305	Participates in initiation and elongation during chromosome replication
GII88_01090	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GII88_01110	COG1396	sequence-specific DNA binding
GII88_01120	COG0457	Tetratricopeptide repeat
GII88_01125	COG5444	nuclease activity
GII88_01145	COG1783	phage Terminase large subunit
GII88_01150	COG5518	Phage portal protein
GII88_01155	COG2369	cell adhesion
GII88_01170	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GII88_01175	COG4653	Phage capsid family
GII88_01230	COG5280	Phage tail tape measure protein TP901
GII88_01230	COG3953	SLT domain
GII88_01230	COG5280	Phage tail tape measure protein TP901
GII88_01230	COG3953	SLT domain
GII88_01235	COG1652	LysM domain
GII88_01240	COG4193	domain, Protein
GII88_01250	COG3628	GPW Gp25 family protein
GII88_01255	COG3299	homolog of phage Mu protein gp47
GII88_01260	COG3778	Protein conserved in bacteria
GII88_01315	COG1793	dna ligase
GII88_01340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GII88_01350	COG0385	Bile acid
GII88_01365	COG3876	Protein conserved in bacteria
GII88_01370	COG1472	Belongs to the glycosyl hydrolase 3 family
GII88_01375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GII88_01380	COG1263	PTS System
GII88_01380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_01385	COG1737	Transcriptional regulator
GII88_01390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GII88_01395	COG1683	Conserved Protein
GII88_01430	COG1595	DNA-templated transcription, initiation
GII88_01435	COG5662	AntiSigma factor
GII88_01440	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GII88_01445	COG4856	YbbR-like protein
GII88_01450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GII88_01455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GII88_01475	COG1725	Transcriptional regulator
GII88_01480	COG0640	Transcriptional regulator
GII88_01485	COG2814	Major facilitator Superfamily
GII88_01495	COG1132	(ABC) transporter
GII88_01500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GII88_01525	COG1011	Hydrolase
GII88_01530	COG1113	amino acid transport
GII88_01535	COG2851	Citrate transporter
GII88_01540	COG3181	Tripartite tricarboxylate transporter family receptor
GII88_01545	COG4565	transcriptional regulatory protein
GII88_01550	COG3290	protein histidine kinase activity
GII88_01565	COG2211	Major facilitator Superfamily
GII88_01585	COG1331	Highly conserved protein containing a thioredoxin domain
GII88_01590	COG3677	Transposase
GII88_01630	COG1331	Highly conserved protein containing a thioredoxin domain
GII88_01640	COG0477	Major facilitator Superfamily
GII88_01660	COG1283	sodium-dependent phosphate transmembrane transporter activity
GII88_01665	COG4682	membrane
GII88_01690	COG0697	spore germination
GII88_01695	COG2207	Transcriptional regulator
GII88_01695	COG1917	Cupin 2, conserved barrel domain protein
GII88_01715	COG0371	Dehydrogenase
GII88_01720	COG0840	transmembrane signaling receptor activity
GII88_01725	COG4213	ABC transporter substrate-binding protein
GII88_01740	COG4257	antibiotic catabolic process
GII88_01750	COG0833	amino acid
GII88_01755	COG2040	homocysteine
GII88_01765	COG2190	(PTS) system
GII88_01765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_01765	COG1263	PTS System
GII88_01770	COG0789	Transcriptional regulator
GII88_01775	COG2323	membrane
GII88_01790	COG2205	protein histidine kinase activity
GII88_01795	COG1115	amino acid carrier protein
GII88_01800	COG2066	Belongs to the glutaminase family
GII88_01805	COG4191	Histidine kinase
GII88_01810	COG0784	Response regulator, receiver
GII88_01835	COG3540	Alkaline phosphatase
GII88_01840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GII88_01845	COG0805	protein transport
GII88_01850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GII88_01855	COG1012	belongs to the aldehyde dehydrogenase family
GII88_01860	COG2271	Major facilitator Superfamily
GII88_01865	COG4948	Mandelate Racemase Muconate Lactonizing
GII88_01870	COG2186	Transcriptional regulator
GII88_01875	COG2721	sulfolactate sulfo-lyase activity
GII88_01880	COG0745	RESPONSE REGULATOR receiver
GII88_01885	COG2205	protein histidine kinase activity
GII88_01890	COG1131	(ABC) transporter
GII88_01915	COG3173	Aminoglycoside phosphotransferase
GII88_01920	COG1846	Transcriptional regulator
GII88_01925	COG0318	PFAM AMP-dependent synthetase and ligase
GII88_01945	COG0789	Transcriptional regulator
GII88_01970	COG0697	spore germination
GII88_01975	COG1714	RDD family
GII88_01980	COG1405	negative regulation of cell septum assembly
GII88_01980	COG3012	SEC-C Motif Domain Protein
GII88_02010	COG0583	DNA-binding transcription factor activity
GII88_02015	COG1942	4-Oxalocrotonate Tautomerase
GII88_02020	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_02035	COG1288	antiporter activity
GII88_02045	COG0456	acetyltransferase
GII88_02055	COG1164	Oligoendopeptidase f
GII88_02060	COG2261	transglycosylase associated protein
GII88_02070	COG0247	lactate metabolic process
GII88_02075	COG0277	FAD linked oxidase domain protein
GII88_02080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII88_02085	COG1447	Phosphotransferase system cellobiose-specific component IIA
GII88_02090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII88_02095	COG1486	melibiose metabolic process
GII88_02105	COG3394	polysaccharide catabolic process
GII88_02120	COG3591	Belongs to the peptidase S1B family
GII88_02125	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_02135	COG1595	DNA-templated transcription, initiation
GII88_02145	COG3773	Cell wall hydrolase
GII88_02150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII88_02155	COG0791	NLP P60 protein
GII88_02155	COG3883	PFAM NLP P60 protein
GII88_02165	COG1131	(ABC) transporter
GII88_02170	COG1309	transcriptional regulator
GII88_02190	COG2310	stress, protein
GII88_02195	COG2310	stress, protein
GII88_02200	COG2310	stress, protein
GII88_02205	COG0861	Integral membrane protein TerC family
GII88_02225	COG3853	Toxic anion resistance protein (TelA)
GII88_02230	COG0785	Cytochrome C biogenesis protein
GII88_02240	COG0789	Transcriptional regulator
GII88_02245	COG2223	nitrite transmembrane transporter activity
GII88_02250	COG0039	L-malate dehydrogenase activity
GII88_02255	COG1620	l-lactate permease
GII88_02260	COG1280	lysine exporter protein (LysE YggA)
GII88_02265	COG1113	amino acid transport
GII88_02270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GII88_02275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GII88_02280	COG3541	Predicted nucleotidyltransferase
GII88_02285	COG0506	proline dehydrogenase activity
GII88_02290	COG1012	belongs to the aldehyde dehydrogenase family
GII88_02295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII88_02300	COG2508	Transcriptional regulator
GII88_02305	COG3689	TIGRFAM TIGR03943 family protein
GII88_02310	COG0701	Predicted permease
GII88_02315	COG3458	cephalosporin-C deacetylase activity
GII88_02335	COG0765	amino acid transport
GII88_02340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII88_02345	COG2249	NAD(P)H dehydrogenase (quinone) activity
GII88_02355	COG2723	6-phospho-beta-galactosidase activity
GII88_02365	COG3209	COG3209 Rhs family protein
GII88_02370	COG3266	domain, Protein
GII88_02370	COG0515	serine threonine protein kinase
GII88_02380	COG5444	nuclease activity
GII88_02405	COG1176	ABC-type spermidine putrescine transport system, permease component I
GII88_02410	COG1177	transmembrane transport
GII88_02415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII88_02420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII88_02425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII88_02430	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GII88_02435	COG0697	spore germination
GII88_02440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII88_02450	COG2819	hydrolase of the alpha beta superfamily
GII88_02460	COG2364	Membrane
GII88_02470	COG1131	(ABC) transporter
GII88_02495	COG1126	abc transporter atp-binding protein
GII88_02500	COG0765	amino acid transport
GII88_02505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII88_02510	COG3829	transcription factor binding
GII88_02515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GII88_02520	COG0833	amino acid
GII88_02525	COG0010	Belongs to the arginase family
GII88_02530	COG0583	DNA-binding transcription factor activity
GII88_02535	COG0163	prenyltransferase activity
GII88_02540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GII88_02590	COG5444	nuclease activity
GII88_02610	COG2972	Histidine kinase
GII88_02615	COG2207	Transcriptional regulator
GII88_02615	COG4753	response regulator
GII88_02620	COG4213	ABC transporter substrate-binding protein
GII88_02630	COG4214	carbohydrate transport
GII88_02635	COG2271	Major facilitator Superfamily
GII88_02640	COG1846	Transcriptional regulator
GII88_02640	COG0456	acetyltransferase
GII88_02645	COG1874	Beta-galactosidase
GII88_02650	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
GII88_02655	COG3104	oligopeptide transport
GII88_02660	COG5434	Belongs to the glycosyl hydrolase 28 family
GII88_02670	COG0697	spore germination
GII88_02680	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GII88_02685	COG0789	Transcriptional regulator
GII88_02690	COG1136	(ABC) transporter
GII88_02695	COG0577	efflux transmembrane transporter activity
GII88_02700	COG0745	RESPONSE REGULATOR receiver
GII88_02705	COG3850	Histidine kinase
GII88_02705	COG5002	protein histidine kinase activity
GII88_02715	COG0527	aspartate kinase activity
GII88_02720	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII88_02725	COG4605	iron ion homeostasis
GII88_02730	COG4604	ABC transporter, ATP-binding protein
GII88_02735	COG4607	ABC-type enterochelin transport system periplasmic component
GII88_02740	COG2814	Major facilitator Superfamily
GII88_02745	COG1309	transcriptional regulator
GII88_02755	COG0778	Nitroreductase
GII88_02760	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GII88_02765	COG0640	Transcriptional regulator
GII88_02770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII88_02775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GII88_02780	COG0531	amino acid
GII88_02785	COG1012	belongs to the aldehyde dehydrogenase family
GII88_02790	COG0697	spore germination
GII88_02800	COG4549	nuclear export factor GLE1
GII88_02805	COG1276	copper resistance
GII88_02805	COG2372	response to copper ion
GII88_02810	COG1349	DNA-binding transcription factor activity
GII88_02815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GII88_02820	COG0243	molybdopterin cofactor binding
GII88_02825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GII88_02830	COG2146	nitrite reductase [NAD(P)H] activity
GII88_02835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GII88_02835	COG1587	Uroporphyrinogen-III synthase
GII88_02840	COG1802	Transcriptional regulator
GII88_02845	COG0471	metal ion transport
GII88_02850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GII88_02855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GII88_02870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII88_02885	COG3959	Transketolase, thiamine diphosphate binding domain
GII88_02890	COG3958	Transketolase
GII88_02895	COG0561	phosphatase activity
GII88_02900	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GII88_02905	COG1914	H( )-stimulated, divalent metal cation uptake system
GII88_02910	COG4336	lyase activity
GII88_02915	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GII88_02920	COG1984	allophanate hydrolase subunit 2
GII88_02925	COG1414	Transcriptional regulator
GII88_02930	COG2755	lipolytic protein G-D-S-L family
GII88_02935	COG2213	PTS system mannitol-specific
GII88_02940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII88_02945	COG0246	Mannitol dehydrogenase
GII88_02950	COG3711	transcriptional antiterminator
GII88_02955	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_02960	COG1917	Cupin 2, conserved barrel domain protein
GII88_02970	COG3871	stress protein (general stress protein 26)
GII88_02980	COG1316	TRANSCRIPTIONal
GII88_02985	COG2814	Major facilitator Superfamily
GII88_02995	COG1522	sequence-specific DNA binding
GII88_03000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GII88_03000	COG0551	DNA topoisomerase type I activity
GII88_03005	COG0531	amino acid
GII88_03010	COG0028	Belongs to the TPP enzyme family
GII88_03015	COG3397	chitin binding
GII88_03025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII88_03030	COG1914	H( )-stimulated, divalent metal cation uptake system
GII88_03035	COG2261	transglycosylase associated protein
GII88_03040	COG1027	Aspartate ammonia-lyase
GII88_03045	COG1819	glycosyl
GII88_03050	COG4876	unkown
GII88_03055	COG2217	Heavy metal translocating P-type atpase
GII88_03065	COG0662	Cupin 2, conserved barrel domain protein
GII88_03070	COG3729	General stress protein
GII88_03075	COG0628	permease
GII88_03080	COG1301	dicarboxylic acid transport
GII88_03085	COG1131	(ABC) transporter
GII88_03090	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GII88_03100	COG1960	acyl-CoA dehydrogenase activity
GII88_03115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII88_03120	COG1181	Belongs to the D-alanine--D-alanine ligase family
GII88_03125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GII88_03135	COG0513	Belongs to the DEAD box helicase family
GII88_03140	COG3402	PFAM membrane-flanked domain
GII88_03145	COG3428	Bacterial PH domain
GII88_03150	COG0705	Rhomboid family
GII88_03155	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GII88_03160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GII88_03165	COG0864	Transcriptional regulator
GII88_03170	COG2337	Toxic component of a toxin-antitoxin (TA) module
GII88_03175	COG1366	Belongs to the anti-sigma-factor antagonist family
GII88_03180	COG1366	Belongs to the anti-sigma-factor antagonist family
GII88_03185	COG2172	sigma factor antagonist activity
GII88_03190	COG2208	phosphoserine phosphatase activity
GII88_03200	COG2172	sigma factor antagonist activity
GII88_03205	COG1191	sigma factor activity
GII88_03210	COG2208	phosphoserine phosphatase activity
GII88_03215	COG2183	response to ionizing radiation
GII88_03220	COG1309	transcriptional regulator
GII88_03225	COG2409	Drug exporters of the RND superfamily
GII88_03225	COG1033	growth of symbiont in host cell
GII88_03235	COG3091	SprT-like family
GII88_03280	COG1476	TRANSCRIPTIONal
GII88_03285	COG3239	Fatty acid desaturase
GII88_03290	COG1278	Cold shock
GII88_03295	COG1063	alcohol dehydrogenase
GII88_03310	COG1846	Transcriptional regulator
GII88_03315	COG0456	acetyltransferase
GII88_03320	COG2808	Putative FMN-binding domain
GII88_03330	COG1733	regulation of RNA biosynthetic process
GII88_03335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII88_03345	COG0583	DNA-binding transcription factor activity
GII88_03360	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GII88_03365	COG1113	amino acid transport
GII88_03380	COG1595	DNA-templated transcription, initiation
GII88_03390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GII88_03390	COG2755	lipolytic protein G-D-S-L family
GII88_03395	COG2814	Major facilitator Superfamily
GII88_03400	COG2972	Histidine kinase
GII88_03400	COG0745	RESPONSE REGULATOR receiver
GII88_03405	COG3279	Response regulator of the LytR AlgR family
GII88_03415	COG3764	Sortase (surface protein transpeptidase)
GII88_03425	COG2814	Major facilitator Superfamily
GII88_03465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GII88_03470	COG0802	atpase or kinase
GII88_03475	COG1214	PFAM Peptidase M22, glycoprotease
GII88_03480	COG0456	acetyltransferase
GII88_03485	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GII88_03490	COG0488	(ABC) transporter
GII88_03495	COG0315	cyclic pyranopterin monophosphate synthase activity
GII88_03500	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GII88_03505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GII88_03510	COG0805	protein transport
GII88_03520	COG1266	CAAX protease self-immunity
GII88_03525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GII88_03530	COG0459	protein refolding
GII88_03570	COG2720	vancomycin resistance protein
GII88_03585	COG2135	peptidase activity
GII88_03595	COG1309	transcriptional regulator
GII88_03600	COG3848	Pyruvate phosphate dikinase
GII88_03600	COG0574	Belongs to the PEP-utilizing enzyme family
GII88_03610	COG3189	MarR family transcriptional regulator
GII88_03615	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GII88_03620	COG2272	Belongs to the type-B carboxylesterase lipase family
GII88_03625	COG2814	Major facilitator Superfamily
GII88_03630	COG1842	Phage shock protein A
GII88_03635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GII88_03640	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GII88_03645	COG4260	virion core protein, lumpy skin disease virus
GII88_03655	COG1378	Sugar-specific transcriptional regulator TrmB
GII88_03660	COG1280	lysine exporter protein (LysE YggA)
GII88_03665	COG3339	Conserved Protein
GII88_03670	COG0772	Belongs to the SEDS family
GII88_03675	COG0772	Belongs to the SEDS family
GII88_03700	COG0726	polysaccharide deacetylase
GII88_03710	COG1609	Transcriptional regulator
GII88_03715	COG0366	Alpha amylase catalytic
GII88_03720	COG2182	Extracellular solute-binding protein
GII88_03725	COG1175	transmembrane transport
GII88_03730	COG3833	ABC-type maltose transport systems, permease component
GII88_03735	COG5521	maltodextrose utilization protein MalA
GII88_03740	COG1554	hydrolase, family 65, central catalytic
GII88_03745	COG0366	Alpha amylase catalytic
GII88_03750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GII88_03755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GII88_03760	COG1846	Transcriptional regulator
GII88_03775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GII88_03780	COG0823	Involved in the tonB-independent uptake of proteins
GII88_03810	COG0702	epimerase
GII88_03820	COG2132	Multicopper oxidase
GII88_03835	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GII88_03840	COG0714	Associated with various cellular activities
GII88_03845	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GII88_03850	COG1305	Transglutaminase-like
GII88_03855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GII88_03855	COG0519	Catalyzes the synthesis of GMP from XMP
GII88_03865	COG2252	PERMEase
GII88_03880	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GII88_03890	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GII88_03895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GII88_03900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GII88_03905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GII88_03910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GII88_03915	COG0047	phosphoribosylformylglycinamidine synthase activity
GII88_03920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GII88_03925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GII88_03930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GII88_03935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GII88_03940	COG0138	bifunctional purine biosynthesis protein purh
GII88_03945	COG0151	Belongs to the GarS family
GII88_03960	COG2124	cytochrome p450
GII88_03980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GII88_03985	COG1470	cell adhesion involved in biofilm formation
GII88_03990	COG4496	protein, YerC YecD
GII88_03995	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GII88_04000	COG0210	DNA helicase
GII88_04005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GII88_04010	COG4851	CamS sex pheromone cAM373 precursor
GII88_04020	COG2188	Transcriptional regulator
GII88_04040	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GII88_04045	COG0626	cystathionine gamma-synthase activity
GII88_04050	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GII88_04055	COG3457	Alanine racemase
GII88_04060	COG0363	glucosamine-6-phosphate deaminase activity
GII88_04065	COG1285	pathogenesis
GII88_04070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII88_04075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GII88_04080	COG0154	amidase activity
GII88_04085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GII88_04100	COG4124	Belongs to the glycosyl hydrolase 26 family
GII88_04105	COG1309	transcriptional regulator
GII88_04110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GII88_04120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII88_04125	COG1957	nucleoside hydrolase
GII88_04130	COG1597	lipid kinase activity
GII88_04135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GII88_04145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_04145	COG2190	(PTS) system
GII88_04145	COG1263	PTS System
GII88_04150	COG2723	6-phospho-beta-galactosidase activity
GII88_04155	COG3711	transcriptional antiterminator
GII88_04160	COG0457	Tetratricopeptide repeat
GII88_04175	COG0217	transcriptional regulatory protein
GII88_04190	COG1012	belongs to the aldehyde dehydrogenase family
GII88_04195	COG0840	transmembrane signaling receptor activity
GII88_04200	COG0471	metal ion transport
GII88_04205	COG0488	(ABC) transporter
GII88_04215	COG1469	GTP cyclohydrolase I activity
GII88_04230	COG0523	cobalamin synthesis protein
GII88_04235	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
GII88_04240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GII88_04245	COG0156	8-amino-7-oxononanoate synthase activity
GII88_04250	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GII88_04255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GII88_04260	COG2124	cytochrome p450
GII88_04270	COG0789	Transcriptional regulator
GII88_04275	COG2814	Major facilitator Superfamily
GII88_04280	COG0488	(ABC) transporter
GII88_04285	COG0513	Belongs to the DEAD box helicase family
GII88_04290	COG2130	NADP-dependent
GII88_04305	COG0471	metal ion transport
GII88_04325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII88_04335	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GII88_04340	COG5658	integral membrane protein
GII88_04345	COG0640	Transcriptional regulator
GII88_04350	COG1254	Belongs to the acylphosphatase family
GII88_04355	COG2258	MOSC domain
GII88_04365	COG0024	Methionine aminopeptidase
GII88_04370	COG1368	sulfuric ester hydrolase activity
GII88_04380	COG1115	amino acid carrier protein
GII88_04385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_04385	COG1263	PTS System
GII88_04390	COG0366	Alpha amylase catalytic
GII88_04395	COG2188	Transcriptional regulator
GII88_04420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GII88_04425	COG1045	serine acetyltransferase
GII88_04430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GII88_04440	COG1215	transferase activity, transferring glycosyl groups
GII88_04445	COG0457	Tetratricopeptide repeat
GII88_04445	COG0463	Glycosyl transferase, family 2
GII88_04455	COG0673	inositol 2-dehydrogenase activity
GII88_04470	COG1733	regulation of RNA biosynthetic process
GII88_04475	COG0778	Nitroreductase
GII88_04480	COG0737	Belongs to the 5'-nucleotidase family
GII88_04485	COG0693	protein deglycase activity
GII88_04490	COG4840	Belongs to the UPF0435 family
GII88_04495	COG1115	amino acid carrier protein
GII88_04500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GII88_04505	COG4980	gas vesicle protein
GII88_04510	COG1295	ribonuclease BN
GII88_04515	COG0477	Major facilitator Superfamily
GII88_04525	COG0387	Pfam Sodium calcium exchanger
GII88_04535	COG0535	radical SAM domain protein
GII88_04545	COG0726	polysaccharide deacetylase
GII88_04550	COG0371	Dehydrogenase
GII88_04560	COG0598	Magnesium transport protein CorA
GII88_04565	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GII88_04570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GII88_04575	COG4637	Psort location Cytoplasmic, score
GII88_04600	COG1819	glycosyl
GII88_04610	COG0477	Major facilitator Superfamily
GII88_04615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_04615	COG1263	PTS System
GII88_04620	COG3711	transcriptional antiterminator
GII88_04625	COG0288	reversible hydration of carbon dioxide
GII88_04630	COG3002	Belongs to the UPF0753 family
GII88_04635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GII88_04640	COG5609	conserved protein (DUF2294)
GII88_04650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GII88_04655	COG0022	dehydrogenase e1 component
GII88_04660	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII88_04665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GII88_04670	COG3284	Transcriptional regulator
GII88_04675	COG1742	UPF0060 membrane protein
GII88_04680	COG1486	melibiose metabolic process
GII88_04685	COG1737	Transcriptional regulator
GII88_04690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_04690	COG1263	PTS System
GII88_04705	COG1733	regulation of RNA biosynthetic process
GII88_04710	COG2259	Doxx family
GII88_04715	COG2514	catechol 2,3-dioxygenase activity
GII88_04725	COG3507	Belongs to the glycosyl hydrolase 43 family
GII88_04730	COG1917	Cupin 2, conserved barrel domain protein
GII88_04730	COG2207	Transcriptional regulator
GII88_04735	COG1653	transport
GII88_04740	COG2249	NAD(P)H dehydrogenase (quinone) activity
GII88_04745	COG1051	belongs to the nudix hydrolase family
GII88_04760	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GII88_04760	COG0392	lysyltransferase activity
GII88_04765	COG0384	phenazine biosynthesis protein PhzF
GII88_04770	COG0778	Nitroreductase
GII88_04790	COG1090	epimerase
GII88_04795	COG2137	regulation of response to DNA damage stimulus
GII88_04825	COG0463	Glycosyl transferase, family 2
GII88_04835	COG4485	Bacterial membrane protein, YfhO
GII88_04840	COG1988	membrane-bound metal-dependent
GII88_04845	COG1194	a g-specific adenine glycosylase
GII88_04855	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_04870	COG3557	Belongs to the UPF0374 family
GII88_04875	COG1132	(ABC) transporter
GII88_04880	COG0444	Belongs to the ABC transporter superfamily
GII88_04885	COG4608	Belongs to the ABC transporter superfamily
GII88_04890	COG0747	negative chemotaxis
GII88_04905	COG4129	membrane
GII88_04910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GII88_04915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GII88_04920	COG0735	belongs to the Fur family
GII88_05030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GII88_05040	COG0710	3-dehydroquinate dehydratase activity
GII88_05045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GII88_05050	COG1116	anion transmembrane transporter activity
GII88_05055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GII88_05060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GII88_05065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII88_05075	COG1476	TRANSCRIPTIONal
GII88_05085	COG1131	(ABC) transporter
GII88_05105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GII88_05115	COG3382	B3 4 domain protein
GII88_05120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GII88_05130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GII88_05135	COG0789	Transcriptional regulator
GII88_05140	COG1664	Polymer-forming cytoskeletal
GII88_05150	COG2766	serine protein kinase
GII88_05155	COG2718	Belongs to the UPF0229 family
GII88_05160	COG1566	PFAM secretion protein HlyD family protein
GII88_05165	COG2814	Major facilitator Superfamily
GII88_05170	COG0655	NAD(P)H dehydrogenase (quinone) activity
GII88_05185	COG1131	(ABC) transporter
GII88_05190	COG1131	(ABC) transporter
GII88_05195	COG1131	(ABC) transporter
GII88_05200	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GII88_05205	COG1278	Cold shock
GII88_05210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GII88_05215	COG2011	ABC-type metal ion transport system permease component
GII88_05220	COG1464	Belongs to the NlpA lipoprotein family
GII88_05225	COG1823	symporter activity
GII88_05250	COG5577	PFAM Coat F domain
GII88_05255	COG5002	protein histidine kinase activity
GII88_05260	COG0737	Belongs to the 5'-nucleotidase family
GII88_05260	COG4085	toxin activity
GII88_05260	COG1525	nuclease
GII88_05265	COG3764	Sortase (surface protein transpeptidase)
GII88_05270	COG0564	pseudouridine synthase activity
GII88_05280	COG0517	IMP dehydrogenase activity
GII88_05285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GII88_05290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GII88_05290	COG3153	acetyltransferase
GII88_05295	COG0488	(ABC) transporter
GII88_05300	COG2116	formate transmembrane transporter activity
GII88_05305	COG0679	Auxin Efflux Carrier
GII88_05310	COG0604	alcohol dehydrogenase
GII88_05315	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GII88_05320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GII88_05325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GII88_05330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GII88_05335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GII88_05350	COG4585	Histidine kinase
GII88_05350	COG2203	Gaf domain
GII88_05355	COG2197	response regulator
GII88_05360	COG0431	NADPH-dependent FMN reductase
GII88_05375	COG1959	2 iron, 2 sulfur cluster binding
GII88_05380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GII88_05380	COG1017	nitric oxide dioxygenase activity
GII88_05385	COG2719	SpoVR family
GII88_05390	COG0791	NLP P60 protein
GII88_05390	COG1388	LysM domain
GII88_05395	COG0583	DNA-binding transcription factor activity
GII88_05400	COG0372	Belongs to the citrate synthase family
GII88_05405	COG2133	pyrroloquinoline quinone binding
GII88_05410	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_05415	COG0733	neurotransmitter:sodium symporter activity
GII88_05425	COG2207	Transcriptional regulator
GII88_05425	COG3708	Transcriptional regulator
GII88_05430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII88_05450	COG1595	DNA-templated transcription, initiation
GII88_05455	COG0662	Cupin 2, conserved barrel domain protein
GII88_05465	COG0204	Acyl-transferase
GII88_05470	COG3152	Membrane
GII88_05480	COG1309	transcriptional regulator
GII88_05485	COG1253	flavin adenine dinucleotide binding
GII88_05490	COG0789	Transcriptional regulator
GII88_05495	COG1253	flavin adenine dinucleotide binding
GII88_05515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GII88_05520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GII88_05525	COG0584	glycerophosphoryl diester phosphodiesterase
GII88_05535	COG0668	transmembrane transport
GII88_05540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GII88_05550	COG0726	polysaccharide deacetylase
GII88_05560	COG1757	Na H antiporter
GII88_05565	COG2017	converts alpha-aldose to the beta-anomer
GII88_05590	COG0589	response to stress
GII88_05595	COG1132	(ABC) transporter
GII88_05600	COG1132	(ABC) transporter
GII88_05605	COG0702	epimerase
GII88_05620	COG3842	ATPase activity
GII88_05625	COG2508	Transcriptional regulator
GII88_05635	COG0189	ligase activity
GII88_05640	COG0189	ligase activity
GII88_05645	COG4399	Belongs to the UPF0754 family
GII88_05650	COG3679	Belongs to the UPF0342 family
GII88_05660	COG0561	phosphatase activity
GII88_05665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GII88_05670	COG0475	glutathione-regulated potassium exporter activity
GII88_05675	COG0490	domain, Protein
GII88_05685	COG1024	Enoyl-CoA hydratase
GII88_05690	COG0457	Tetratricopeptide repeat
GII88_05705	COG4152	abc transporter atp-binding protein
GII88_05710	COG1668	transmembrane transport
GII88_05715	COG0420	3'-5' exonuclease activity
GII88_05725	COG3481	metal-dependent phosphohydrolase, HD sub domain
GII88_05735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GII88_05765	COG1846	Transcriptional regulator
GII88_05770	COG4980	gas vesicle protein
GII88_05785	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GII88_05790	COG0537	adenosine 5'-monophosphoramidase activity
GII88_05795	COG1131	(ABC) transporter
GII88_05800	COG4473	ABC transporter
GII88_05810	COG1473	amidohydrolase
GII88_05815	COG3069	C4-dicarboxylate transmembrane transporter activity
GII88_05820	COG2329	Antibiotic biosynthesis monooxygenase
GII88_05825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII88_05830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GII88_05845	COG1309	transcriptional regulator
GII88_05850	COG1511	domain protein
GII88_05855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GII88_05860	COG1363	Peptidase, m42
GII88_05870	COG1301	dicarboxylic acid transport
GII88_05880	COG1234	tRNA 3'-trailer cleavage
GII88_05885	COG0095	Lipoate-protein ligase
GII88_05890	COG0318	PFAM AMP-dependent synthetase and ligase
GII88_05900	COG1396	sequence-specific DNA binding
GII88_05915	COG0501	Belongs to the peptidase M48B family
GII88_05925	COG0697	spore germination
GII88_05930	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GII88_05935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII88_05940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII88_05945	COG0406	alpha-ribazole phosphatase activity
GII88_05950	COG0840	transmembrane signaling receptor activity
GII88_05955	COG0723	plastoquinol--plastocyanin reductase activity
GII88_05955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GII88_05960	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_05970	COG4903	ComK protein
GII88_05980	COG0398	Pfam SNARE associated Golgi protein
GII88_05985	COG0681	Belongs to the peptidase S26 family
GII88_05990	COG1404	Belongs to the peptidase S8 family
GII88_06000	COG2508	Transcriptional regulator
GII88_06010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GII88_06015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII88_06020	COG3257	ureidoglycine aminohydrolase activity
GII88_06025	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GII88_06030	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GII88_06035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GII88_06040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GII88_06050	COG0549	Belongs to the carbamate kinase family
GII88_06055	COG2814	Major facilitator Superfamily
GII88_06065	COG0457	Tetratricopeptide repeat
GII88_06105	COG1486	melibiose metabolic process
GII88_06110	COG3180	Ammonia monooxygenase
GII88_06125	COG3546	catalase activity
GII88_06130	COG0318	PFAM AMP-dependent synthetase and ligase
GII88_06135	COG2814	Major facilitator Superfamily
GII88_06135	COG0477	Major facilitator Superfamily
GII88_06145	COG5002	protein histidine kinase activity
GII88_06150	COG0745	RESPONSE REGULATOR receiver
GII88_06155	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GII88_06160	COG0725	ABC transporter, periplasmic molybdate-binding protein
GII88_06165	COG4149	molybdate abc transporter
GII88_06170	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GII88_06175	COG1074	ATP-dependent DNA helicase activity
GII88_06180	COG0420	3'-5' exonuclease activity
GII88_06185	COG0419	ATPase involved in DNA repair
GII88_06230	COG5337	Spore coat protein CotH
GII88_06240	COG0179	Fumarylacetoacetate (FAA) hydrolase
GII88_06260	COG0367	asparagine synthase
GII88_06270	COG0347	Belongs to the P(II) protein family
GII88_06275	COG0534	Mate efflux family protein
GII88_06280	COG2207	Transcriptional regulator
GII88_06280	COG1917	Cupin 2, conserved barrel domain protein
GII88_06290	COG1609	Transcriptional regulator
GII88_06295	COG0673	inositol 2-dehydrogenase activity
GII88_06300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII88_06310	COG0076	glutamate decarboxylase activity
GII88_06335	COG2153	protein acetylation
GII88_06340	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_06345	COG2378	regulation of single-species biofilm formation
GII88_06350	COG1410	methionine synthase
GII88_06350	COG0646	methionine synthase
GII88_06355	COG0646	methionine synthase
GII88_06355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GII88_06360	COG1666	GTP binding
GII88_06365	COG2996	Protein conserved in bacteria
GII88_06380	COG1307	EDD domain protein, DegV family
GII88_06385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII88_06395	COG0516	GMP reductase activity
GII88_06405	COG0561	phosphatase activity
GII88_06410	COG1073	alpha beta
GII88_06415	COG2151	metal-sulfur cluster biosynthetic enzyme
GII88_06425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GII88_06430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GII88_06435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GII88_06440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GII88_06445	COG0505	Belongs to the CarA family
GII88_06450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GII88_06455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GII88_06460	COG1968	undecaprenyl-diphosphatase activity
GII88_06475	COG2267	carboxylic ester hydrolase activity
GII88_06485	COG1744	ABC transporter substrate-binding protein PnrA-like
GII88_06500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GII88_06505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GII88_06510	COG5504	Zn-dependent protease
GII88_06515	COG0444	Belongs to the ABC transporter superfamily
GII88_06520	COG4608	Belongs to the ABC transporter superfamily
GII88_06530	COG0601	transmembrane transport
GII88_06535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GII88_06560	COG0180	Tryptophanyl-tRNA synthetase
GII88_06565	COG4166	transmembrane transport
GII88_06570	COG0601	transmembrane transport
GII88_06575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GII88_06580	COG0444	Belongs to the ABC transporter superfamily
GII88_06585	COG4608	Belongs to the ABC transporter superfamily
GII88_06590	COG0456	acetyltransferase
GII88_06595	COG1393	Belongs to the ArsC family
GII88_06600	COG0861	Integral membrane protein TerC family
GII88_06610	COG4862	establishment of competence for transformation
GII88_06630	COG4565	transcriptional regulatory protein
GII88_06635	COG3290	protein histidine kinase activity
GII88_06640	COG4469	Competence protein
GII88_06645	COG1164	Oligoendopeptidase f
GII88_06655	COG2346	COG2346, Truncated hemoglobins
GII88_06660	COG0741	lytic transglycosylase activity
GII88_06665	COG4116	CYTH
GII88_06675	COG2357	RelA SpoT domain protein
GII88_06680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GII88_06685	COG0564	pseudouridine synthase activity
GII88_06690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GII88_06700	COG0475	glutathione-regulated potassium exporter activity
GII88_06700	COG0569	domain protein
GII88_06705	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GII88_06710	COG0352	thiamine-phosphate diphosphorylase activity
GII88_06720	COG2104	thiamine diphosphate biosynthetic process
GII88_06725	COG2022	thiamine diphosphate biosynthetic process
GII88_06730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GII88_06735	COG0351	phosphomethylpyrimidine kinase
GII88_06740	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GII88_06795	COG0210	DNA helicase
GII88_06805	COG0586	Pfam SNARE associated Golgi protein
GII88_06810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GII88_06815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GII88_06820	COG2246	polysaccharide biosynthetic process
GII88_06825	COG2153	protein acetylation
GII88_06830	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GII88_06835	COG2382	esterase
GII88_06855	COG0626	cystathionine gamma-synthase activity
GII88_06860	COG0626	cystathionine gamma-synthase activity
GII88_06865	COG5505	Protein of unknown function (DUF819)
GII88_06880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GII88_06885	COG3507	Belongs to the glycosyl hydrolase 43 family
GII88_06905	COG0110	maltose O-acetyltransferase activity
GII88_06915	COG0583	DNA-binding transcription factor activity
GII88_06920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GII88_06925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GII88_06935	COG0583	DNA-binding transcription factor activity
GII88_06940	COG0697	spore germination
GII88_06945	COG0346	lactoylglutathione lyase activity
GII88_06955	COG3584	3D domain protein
GII88_06955	COG1388	LysM domain
GII88_06960	COG2814	Major facilitator Superfamily
GII88_06965	COG1309	transcriptional regulator
GII88_06985	COG5444	nuclease activity
GII88_06990	COG4195	phage-related replication protein
GII88_06995	COG2856	Zn peptidase
GII88_07000	COG1396	sequence-specific DNA binding
GII88_07015	COG1522	sequence-specific DNA binding
GII88_07020	COG1484	DNA-dependent DNA replication
GII88_07035	COG1595	DNA-templated transcription, initiation
GII88_07040	COG5484	DNA packaging
GII88_07040	COG3728	DNA packaging
GII88_07045	COG1783	phage Terminase large subunit
GII88_07050	COG5518	Phage portal protein
GII88_07055	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GII88_07060	COG4653	Phage capsid family
GII88_07110	COG5412	phage tail tape measure protein
GII88_07110	COG3953	SLT domain
GII88_07115	COG1652	LysM domain
GII88_07120	COG4193	domain, Protein
GII88_07130	COG3628	GPW Gp25 family protein
GII88_07135	COG3299	homolog of phage Mu protein gp47
GII88_07140	COG3778	Protein conserved in bacteria
GII88_07175	COG1802	Transcriptional regulator
GII88_07180	COG1063	alcohol dehydrogenase
GII88_07185	COG1312	Catalyzes the dehydration of D-mannonate
GII88_07190	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_07195	COG1063	alcohol dehydrogenase
GII88_07200	COG2271	Major facilitator Superfamily
GII88_07215	COG0306	phosphate transporter
GII88_07220	COG1392	Phosphate transport regulator
GII88_07225	COG0405	Gamma-glutamyltransferase
GII88_07230	COG5578	integral membrane protein
GII88_07235	COG2972	Histidine kinase
GII88_07240	COG2207	Transcriptional regulator
GII88_07240	COG4753	response regulator
GII88_07245	COG1653	transport
GII88_07250	COG1175	transmembrane transport
GII88_07255	COG0395	ABC-type sugar transport system, permease component
GII88_07260	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GII88_07265	COG2207	Transcriptional regulator
GII88_07270	COG2755	lipolytic protein G-D-S-L family
GII88_07280	COG5578	integral membrane protein
GII88_07285	COG3401	FG-GAP repeat protein
GII88_07295	COG2755	lipolytic protein G-D-S-L family
GII88_07300	COG3401	FG-GAP repeat protein
GII88_07305	COG0667	Aldo Keto reductase
GII88_07310	COG2755	lipolytic protein G-D-S-L family
GII88_07315	COG1874	Beta-galactosidase
GII88_07325	COG1653	transport
GII88_07330	COG4209	transmembrane transport
GII88_07335	COG0395	ABC-type sugar transport system, permease component
GII88_07340	COG0531	amino acid
GII88_07345	COG0346	lactoylglutathione lyase activity
GII88_07355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII88_07360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GII88_07365	COG2362	D-Aminopeptidase
GII88_07370	COG0601	transmembrane transport
GII88_07375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GII88_07380	COG0444	Belongs to the ABC transporter superfamily
GII88_07385	COG4166	transmembrane transport
GII88_07390	COG1619	proteins homologs of microcin C7 resistance protein MccF
GII88_07400	COG0791	NLP P60 protein
GII88_07405	COG4608	Belongs to the ABC transporter superfamily
GII88_07410	COG1834	amidinotransferase
GII88_07415	COG1607	acyl-coa hydrolase
GII88_07425	COG3866	Pectate lyase
GII88_07445	COG2318	DinB family
GII88_07450	COG2076	Multidrug Resistance protein
GII88_07455	COG2076	Multidrug Resistance protein
GII88_07460	COG0788	formyltetrahydrofolate deformylase activity
GII88_07465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GII88_07470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GII88_07475	COG1764	response to oxidative stress
GII88_07480	COG1846	Transcriptional regulator
GII88_07485	COG1764	response to oxidative stress
GII88_07495	COG0590	tRNA wobble adenosine to inosine editing
GII88_07500	COG0406	alpha-ribazole phosphatase activity
GII88_07515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GII88_07520	COG1404	Belongs to the peptidase S8 family
GII88_07530	COG2239	Acts as a magnesium transporter
GII88_07540	COG0789	Transcriptional regulator
GII88_07555	COG1846	Transcriptional regulator
GII88_07560	COG1793	dna ligase
GII88_07560	COG3285	dna ligase
GII88_07565	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GII88_07570	COG5001	Diguanylate cyclase
GII88_07570	COG3300	MHYT domain
GII88_07575	COG0586	Pfam SNARE associated Golgi protein
GII88_07580	COG0861	Integral membrane protein TerC family
GII88_07585	COG1191	sigma factor activity
GII88_07605	COG0501	Belongs to the peptidase M48B family
GII88_07610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GII88_07615	COG0768	penicillin binding
GII88_07630	COG3594	Acyltransferase
GII88_07635	COG5002	protein histidine kinase activity
GII88_07640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GII88_07645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GII88_07650	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GII88_07655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GII88_07660	COG0436	Aminotransferase
GII88_07665	COG1850	ribulose-bisphosphate carboxylase activity
GII88_07670	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GII88_07670	COG0235	Class ii aldolase
GII88_07675	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GII88_07680	COG0346	lactoylglutathione lyase activity
GII88_07685	COG3339	Conserved Protein
GII88_07695	COG3852	Histidine kinase
GII88_07700	COG1846	Transcriptional regulator
GII88_07705	COG1360	Flagellar Motor Protein
GII88_07710	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GII88_07715	COG0542	response to heat
GII88_07720	COG3949	Membrane
GII88_07725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GII88_07730	COG0720	synthase
GII88_07735	COG0602	queuosine metabolic process
GII88_07740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GII88_07750	COG3739	integral membrane protein
GII88_07755	COG3655	Transcriptional regulator
GII88_07790	COG4873	Protein conserved in bacteria
GII88_07800	COG3773	Cell wall hydrolase
GII88_07805	COG2244	polysaccharide biosynthetic process
GII88_07810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII88_07815	COG2217	Heavy metal translocating P-type atpase
GII88_07820	COG0006	proline dipeptidase activity
GII88_07830	COG1609	Transcriptional regulator
GII88_07835	COG3711	transcriptional antiterminator
GII88_07840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_07840	COG2190	(PTS) system
GII88_07840	COG1263	PTS System
GII88_07845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII88_07850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GII88_07860	COG1533	DNA photolyase activity
GII88_07865	COG0456	acetyltransferase
GII88_07870	COG0840	transmembrane signaling receptor activity
GII88_07875	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_07880	COG2084	Dehydrogenase
GII88_07885	COG2340	Cysteine-rich secretory protein family
GII88_07890	COG0768	penicillin binding
GII88_07895	COG4191	Histidine kinase
GII88_07900	COG0436	Aminotransferase
GII88_07905	COG1714	RDD family
GII88_07915	COG0835	chemotaxis
GII88_07915	COG0784	Response regulator, receiver
GII88_07925	COG2814	Major facilitator Superfamily
GII88_07930	COG1376	ErfK ybiS ycfS ynhG family protein
GII88_07935	COG1408	metallophosphoesterase
GII88_07940	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_07945	COG2200	EAL domain
GII88_07955	COG4703	Protein of unknown function (DUF1797)
GII88_07960	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GII88_07970	COG0517	IMP dehydrogenase activity
GII88_07975	COG0583	DNA-binding transcription factor activity
GII88_07980	COG0716	FMN binding
GII88_07990	COG0716	FMN binding
GII88_07995	COG2171	N-acyltransferase activity
GII88_08000	COG1473	amidohydrolase
GII88_08010	COG0450	alkyl hydroperoxide reductase
GII88_08015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII88_08030	COG0746	molybdenum cofactor guanylyltransferase activity
GII88_08035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GII88_08040	COG0303	'Molybdopterin
GII88_08045	COG1763	Mo-molybdopterin cofactor biosynthetic process
GII88_08050	COG0314	molybdopterin synthase activity
GII88_08055	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GII88_08065	COG1132	(ABC) transporter
GII88_08070	COG1132	(ABC) transporter
GII88_08080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GII88_08085	COG1136	(ABC) transporter
GII88_08090	COG0577	efflux transmembrane transporter activity
GII88_08095	COG1349	DNA-binding transcription factor activity
GII88_08100	COG1105	Belongs to the carbohydrate kinase PfkB family
GII88_08105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII88_08105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII88_08105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII88_08125	COG0488	(ABC) transporter
GII88_08135	COG2309	aminopeptidase activity
GII88_08145	COG1077	Cell shape determining protein MreB Mrl
GII88_08150	COG2002	toxin-antitoxin pair type II binding
GII88_08155	COG3852	Histidine kinase
GII88_08160	COG0569	domain protein
GII88_08165	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GII88_08170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GII88_08180	COG0561	phosphatase activity
GII88_08190	COG0242	peptide deformylase activity
GII88_08200	COG0497	DNA recombination
GII88_08205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GII88_08210	COG0022	dehydrogenase e1 component
GII88_08215	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII88_08220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GII88_08225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII88_08235	COG1982	Orn Lys Arg decarboxylase major
GII88_08240	COG4476	Belongs to the UPF0223 family
GII88_08245	COG4493	Belongs to the UPF0637 family
GII88_08255	COG0483	inositol monophosphate 1-phosphatase activity
GII88_08275	COG1595	DNA-templated transcription, initiation
GII88_08300	COG1846	Transcriptional regulator
GII88_08305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GII88_08310	COG4896	Protein conserved in bacteria
GII88_08320	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GII88_08325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GII88_08330	COG2066	Belongs to the glutaminase family
GII88_08335	COG4838	Belongs to the UPF0358 family
GII88_08340	COG0772	Belongs to the SEDS family
GII88_08345	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GII88_08350	COG1612	heme a metabolic process
GII88_08355	COG0109	protoheme IX farnesyltransferase activity
GII88_08360	COG2010	Cytochrome c
GII88_08360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GII88_08365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GII88_08370	COG1845	cytochrome c oxidase, subunit III
GII88_08375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GII88_08380	COG3336	cytochrome c oxidase
GII88_08390	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GII88_08395	COG2340	Cysteine-rich secretory protein family
GII88_08410	COG3679	Belongs to the UPF0342 family
GII88_08415	COG4471	UPF0298 protein
GII88_08420	COG0742	ribosomal rna small subunit methyltransferase
GII88_08425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GII88_08430	COG3314	Sporulation integral membrane protein YlbJ
GII88_08435	COG3480	Lon protease (S16) C-terminal proteolytic domain
GII88_08440	COG1323	Belongs to the UPF0348 family
GII88_08445	COG1399	metal-binding, possibly nucleic acid-binding protein
GII88_08450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GII88_08460	COG0454	-acetyltransferase
GII88_08465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GII88_08470	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GII88_08475	COG2001	Belongs to the MraZ family
GII88_08480	COG0275	rRNA processing
GII88_08485	COG4839	cell division protein FtsL
GII88_08495	COG0768	penicillin binding
GII88_08500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GII88_08505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GII88_08510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GII88_08515	COG0772	Belongs to the SEDS family
GII88_08520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GII88_08525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GII88_08530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GII88_08535	COG3879	Bacterial protein of unknown function (DUF881)
GII88_08540	COG3879	Bacterial protein of unknown function (DUF881)
GII88_08545	COG3856	small basic protein
GII88_08550	COG0849	cell division
GII88_08555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GII88_08565	COG1404	Belongs to the peptidase S8 family
GII88_08565	COG4412	M6 family metalloprotease domain protein
GII88_08570	COG4412	M6 family metalloprotease domain protein
GII88_08570	COG1404	Belongs to the peptidase S8 family
GII88_08580	COG1191	sigma factor activity
GII88_08585	COG1191	sigma factor activity
GII88_08590	COG1119	ATPase activity
GII88_08595	COG0500	methyltransferase
GII88_08600	COG1873	PFAM PRC-barrel domain
GII88_08610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GII88_08615	COG1799	cell septum assembly
GII88_08620	COG0762	integral membrane protein
GII88_08625	COG2302	S4 RNA-binding domain
GII88_08630	COG3599	regulation of cell shape
GII88_08635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GII88_08640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GII88_08645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GII88_08650	COG0564	pseudouridine synthase activity
GII88_08655	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GII88_08660	COG2233	PERMEase
GII88_08665	COG0540	Belongs to the ATCase OTCase family
GII88_08670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GII88_08675	COG0505	Belongs to the CarA family
GII88_08680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GII88_08685	COG0543	2 iron, 2 sulfur cluster binding
GII88_08690	COG0167	dihydroorotate dehydrogenase activity
GII88_08695	COG0284	orotidine-5'-phosphate decarboxylase activity
GII88_08700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GII88_08710	COG0175	sulfate reduction
GII88_08715	COG0306	phosphate transporter
GII88_08720	COG2046	Belongs to the sulfate adenylyltransferase family
GII88_08725	COG0529	Catalyzes the synthesis of activated sulfate
GII88_08730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GII88_08735	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GII88_08740	COG1648	precorrin-2 dehydrogenase activity
GII88_08750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GII88_08755	COG1561	YicC-like family, N-terminal region
GII88_08760	COG2052	Domain of unknown function (DUF370)
GII88_08765	COG0194	GDP metabolic process
GII88_08770	COG1758	RNA polymerase activity
GII88_08775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GII88_08780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GII88_08785	COG0242	peptide deformylase activity
GII88_08790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GII88_08795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GII88_08795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GII88_08800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GII88_08805	COG0631	protein serine/threonine phosphatase activity
GII88_08810	COG2815	serine threonine protein kinase
GII88_08810	COG0515	serine threonine protein kinase
GII88_08815	COG1162	GTPase activity
GII88_08820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GII88_08825	COG1564	THIamine pyrophosphokinase
GII88_08835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GII88_08840	COG1302	Protein conserved in bacteria
GII88_08845	COG1461	Dihydroxyacetone kinase
GII88_08850	COG1760	l-serine dehydratase
GII88_08855	COG1760	l-serine dehydratase
GII88_08860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GII88_08865	COG1349	DNA-binding transcription factor activity
GII88_08870	COG0416	fatty acid biosynthetic process
GII88_08875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GII88_08880	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_08885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII88_08890	COG0571	ribonuclease III activity
GII88_08895	COG1196	nuclear chromosome segregation
GII88_08900	COG0552	protein localization to endoplasmic reticulum
GII88_08905	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GII88_08910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GII88_08915	COG0228	four-way junction DNA binding
GII88_08920	COG1837	Belongs to the UPF0109 family
GII88_08930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GII88_08935	COG0336	Belongs to the RNA methyltransferase TrmD family
GII88_08940	COG0335	large ribosomal subunit rRNA binding
GII88_08945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GII88_08950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GII88_08960	COG2257	FlhB HrpN YscU SpaS Family
GII88_08965	COG0045	succinate-CoA ligase (ADP-forming) activity
GII88_08970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GII88_08975	COG0758	DNA mediated transformation
GII88_08980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GII88_08985	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GII88_08990	COG4974	Belongs to the 'phage' integrase family
GII88_08995	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GII88_09000	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GII88_09005	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GII88_09010	COG1815	bacterial-type flagellum-dependent cell motility
GII88_09015	COG1558	bacterial-type flagellum-dependent cell motility
GII88_09020	COG1677	Flagellar hook-basal body complex protein FliE
GII88_09025	COG1766	The M ring may be actively involved in energy transduction
GII88_09030	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GII88_09035	COG1317	bacterial-type flagellum organization
GII88_09040	COG1157	protein secretion by the type III secretion system
GII88_09045	COG2882	bacterial-type flagellum organization
GII88_09055	COG3144	bacterial-type flagellum assembly
GII88_09060	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GII88_09065	COG4786	Flagellar basal body rod
GII88_09070	COG1582	Flagellar protein (FlbD)
GII88_09075	COG1580	Controls the rotational direction of flagella during chemotaxis
GII88_09080	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GII88_09085	COG1776	CheC inhibitor of MCP methylation
GII88_09085	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GII88_09090	COG2201	protein-glutamate methylesterase activity
GII88_09095	COG3190	flagellar
GII88_09100	COG1338	Plays a role in the flagellum-specific transport system
GII88_09105	COG1987	bacterial-type flagellum assembly
GII88_09110	COG1684	flagellar biosynthetic protein fliR
GII88_09115	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GII88_09120	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GII88_09125	COG1419	protein localization to endoplasmic reticulum
GII88_09130	COG0455	bacterial-type flagellum organization
GII88_09135	COG2201	protein-glutamate methylesterase activity
GII88_09140	COG0643	Histidine kinase
GII88_09140	COG2198	Histidine kinase
GII88_09145	COG0835	chemotaxis
GII88_09150	COG1776	CheC inhibitor of MCP methylation
GII88_09155	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GII88_09160	COG1191	sigma factor activity
GII88_09170	COG0052	Belongs to the universal ribosomal protein uS2 family
GII88_09175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GII88_09180	COG0528	UMP kinase activity
GII88_09185	COG0233	cytoplasmic translational termination
GII88_09190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GII88_09195	COG4589	Belongs to the CDS family
GII88_09200	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GII88_09205	COG0750	zinc metalloprotease
GII88_09210	COG0442	prolyl-tRNA aminoacylation
GII88_09215	COG2176	DNA-directed DNA polymerase activity
GII88_09245	COG0779	Required for maturation of 30S ribosomal subunits
GII88_09250	COG0195	Participates in both transcription termination and antitermination
GII88_09255	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GII88_09260	COG1358	cellular component organization or biogenesis
GII88_09265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GII88_09270	COG1550	Protein conserved in bacteria
GII88_09275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GII88_09280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GII88_09285	COG0196	riboflavin kinase activity
GII88_09290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GII88_09295	COG1185	polyribonucleotide nucleotidyltransferase activity
GII88_09300	COG0726	polysaccharide deacetylase
GII88_09305	COG0612	Peptidase, M16
GII88_09310	COG1873	PFAM PRC-barrel domain
GII88_09315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GII88_09320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GII88_09325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GII88_09330	COG0527	aspartate kinase activity
GII88_09340	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GII88_09345	COG0740	serine-type endopeptidase activity
GII88_09355	COG1674	ftsk spoiiie
GII88_09355	COG4980	gas vesicle protein
GII88_09360	COG2188	Transcriptional regulator
GII88_09365	COG2814	Major facilitator Superfamily
GII88_09370	COG0612	Peptidase, M16
GII88_09375	COG0612	Peptidase, M16
GII88_09380	COG0300	oxidoreductase activity
GII88_09395	COG1426	Protein conserved in bacteria
GII88_09400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GII88_09405	COG1546	Belongs to the CinA family
GII88_09405	COG1058	Belongs to the CinA family
GII88_09410	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GII88_09415	COG1418	mRNA catabolic process
GII88_09420	COG1692	metallophosphoesterase
GII88_09425	COG2359	stage V sporulation protein S
GII88_09435	COG1063	alcohol dehydrogenase
GII88_09440	COG0156	8-amino-7-oxononanoate synthase activity
GII88_09445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GII88_09450	COG4550	Control of competence regulator ComK, YlbF/YmcA
GII88_09460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GII88_09465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GII88_09470	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GII88_09475	COG5444	nuclease activity
GII88_09490	COG0523	cobalamin synthesis protein
GII88_09500	COG1247	-acetyltransferase
GII88_09515	COG1231	oxidoreductase activity
GII88_09520	COG3619	membrane
GII88_09525	COG3263	regulation of cellular component size
GII88_09545	COG0393	Putative heavy-metal-binding
GII88_09550	COG0398	Pfam SNARE associated Golgi protein
GII88_09555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GII88_09560	COG1819	glycosyl
GII88_09565	COG0531	amino acid
GII88_09570	COG5577	PFAM Coat F domain
GII88_09585	COG1309	transcriptional regulator
GII88_09590	COG3631	Ketosteroid isomerase-related protein
GII88_09595	COG0702	epimerase
GII88_09605	COG1764	response to oxidative stress
GII88_09610	COG2076	Multidrug Resistance protein
GII88_09615	COG2076	Multidrug Resistance protein
GII88_09630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GII88_09635	COG1923	regulation of RNA biosynthetic process
GII88_09650	COG1780	Probably involved in ribonucleotide reductase function
GII88_09655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII88_09660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII88_09665	COG4112	unkown
GII88_09680	COG0735	belongs to the Fur family
GII88_09685	COG1802	Transcriptional regulator
GII88_09690	COG0697	spore germination
GII88_09725	COG1309	transcriptional regulator
GII88_09775	COG0464	growth
GII88_09780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GII88_09785	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GII88_09790	COG0789	Transcriptional regulator
GII88_09795	COG0174	glutamine synthetase
GII88_09835	COG1073	alpha beta
GII88_09875	COG1309	transcriptional regulator
GII88_09880	COG2076	Multidrug Resistance protein
GII88_09885	COG2076	Multidrug Resistance protein
GII88_09890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII88_09910	COG3546	catalase activity
GII88_09935	COG1846	Transcriptional regulator
GII88_09940	COG0778	Nitroreductase
GII88_09945	COG0346	lactoylglutathione lyase activity
GII88_09950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GII88_09955	COG0655	NAD(P)H dehydrogenase (quinone) activity
GII88_09970	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GII88_09975	COG3209	COG3209 Rhs family protein
GII88_09980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GII88_09985	COG1388	LysM domain
GII88_09990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GII88_09995	COG4224	UPF0291 protein
GII88_10000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GII88_10010	COG3763	UPF0154 protein
GII88_10020	COG0785	Cytochrome C biogenesis protein
GII88_10025	COG2201	protein-glutamate methylesterase activity
GII88_10030	COG4846	Membrane protein involved in cytochrome C biogenesis
GII88_10040	COG0071	Belongs to the small heat shock protein (HSP20) family
GII88_10055	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GII88_10060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII88_10080	COG0824	Thioesterase
GII88_10105	COG4841	protein insertion into membrane
GII88_10110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GII88_10115	COG1832	CoA-binding protein
GII88_10120	COG0187	DNA topoisomerase II activity
GII88_10125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GII88_10130	COG1609	Transcriptional regulator
GII88_10145	COG2160	L-arabinose isomerase activity
GII88_10165	COG1115	amino acid carrier protein
GII88_10175	COG2181	nitrate reductase activity
GII88_10180	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GII88_10185	COG1140	nitrate reductase beta subunit
GII88_10190	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GII88_10210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GII88_10220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GII88_10225	COG2223	nitrite transmembrane transporter activity
GII88_10245	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GII88_10265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII88_10275	COG0492	ferredoxin-NADP+ reductase activity
GII88_10290	COG3420	alginic acid biosynthetic process
GII88_10295	COG1114	Component of the transport system for branched-chain amino acids
GII88_10300	COG1064	alcohol dehydrogenase
GII88_10305	COG0789	Transcriptional regulator
GII88_10330	COG1024	Enoyl-CoA hydratase
GII88_10335	COG1012	belongs to the aldehyde dehydrogenase family
GII88_10340	COG2084	Dehydrogenase
GII88_10345	COG1960	acyl-CoA dehydrogenase activity
GII88_10350	COG1482	cell wall glycoprotein biosynthetic process
GII88_10355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII88_10355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII88_10355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII88_10375	COG3711	transcriptional antiterminator
GII88_10375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII88_10390	COG1725	Transcriptional regulator
GII88_10395	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_10400	COG1312	Catalyzes the dehydration of D-mannonate
GII88_10415	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GII88_10425	COG1609	Transcriptional regulator
GII88_10430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GII88_10435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GII88_10440	COG0640	Transcriptional regulator
GII88_10445	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GII88_10460	COG1649	PFAM Uncharacterised BCR, COG1649
GII88_10465	COG2404	hydrolase activity, acting on ester bonds
GII88_10470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GII88_10480	COG2027	D-alanyl-D-alanine carboxypeptidase
GII88_10485	COG1252	NADH dehydrogenase
GII88_10500	COG0166	Belongs to the GPI family
GII88_10510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GII88_10515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GII88_10520	COG1024	Enoyl-CoA hydratase
GII88_10525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GII88_10530	COG0511	ligase activity, forming carbon-carbon bonds
GII88_10535	COG0439	Biotin carboxylase
GII88_10540	COG0318	PFAM AMP-dependent synthetase and ligase
GII88_10545	COG1960	acyl-CoA dehydrogenase activity
GII88_10550	COG2249	NAD(P)H dehydrogenase (quinone) activity
GII88_10555	COG1733	regulation of RNA biosynthetic process
GII88_10560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GII88_10565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GII88_10575	COG2323	membrane
GII88_10585	COG0306	phosphate transporter
GII88_10590	COG0175	sulfate reduction
GII88_10595	COG1809	phosphosulfolactate synthase activity
GII88_10600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII88_10605	COG4948	Mandelate Racemase Muconate Lactonizing
GII88_10610	COG2814	Major facilitator Superfamily
GII88_10615	COG0463	Glycosyl transferase, family 2
GII88_10630	COG0493	'glutamate synthase
GII88_10635	COG0070	glutamate synthase
GII88_10635	COG0067	glutamate synthase
GII88_10635	COG0069	glutamate synthase activity
GII88_10640	COG0583	DNA-binding transcription factor activity
GII88_10660	COG1846	Transcriptional regulator
GII88_10670	COG1132	(ABC) transporter
GII88_10680	COG0300	oxidoreductase activity
GII88_10685	COG3848	Pyruvate phosphate dikinase
GII88_10685	COG0574	Belongs to the PEP-utilizing enzyme family
GII88_10695	COG0477	Major facilitator Superfamily
GII88_10700	COG0243	molybdopterin cofactor binding
GII88_10705	COG1846	Transcriptional regulator
GII88_10715	COG0531	amino acid
GII88_10725	COG0531	amino acid
GII88_10730	COG0531	amino acid
GII88_10735	COG0697	spore germination
GII88_10745	COG0840	transmembrane signaling receptor activity
GII88_10750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII88_10755	COG1404	Belongs to the peptidase S8 family
GII88_10765	COG1309	transcriptional regulator
GII88_10770	COG1846	Transcriptional regulator
GII88_10800	COG1309	transcriptional regulator
GII88_10805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII88_10810	COG3708	Transcriptional regulator
GII88_10820	COG2378	regulation of single-species biofilm formation
GII88_10830	COG0640	Transcriptional regulator
GII88_10835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII88_10845	COG0531	amino acid
GII88_10850	COG0741	lytic transglycosylase activity
GII88_10855	COG1086	Polysaccharide biosynthesis protein
GII88_10875	COG2322	membrane
GII88_10890	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII88_10895	COG3584	3D domain protein
GII88_10895	COG1388	LysM domain
GII88_10900	COG0514	ATP-dependent DNA helicase (RecQ)
GII88_10920	COG2315	Protein conserved in bacteria
GII88_10940	COG2427	Protein of unknown function (DUF1641)
GII88_10960	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GII88_11005	COG0402	S-adenosylhomocysteine deaminase activity
GII88_11020	COG2267	carboxylic ester hydrolase activity
GII88_11035	COG1280	lysine exporter protein (LysE YggA)
GII88_11040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GII88_11050	COG3848	Pyruvate phosphate dikinase
GII88_11050	COG0574	Belongs to the PEP-utilizing enzyme family
GII88_11055	COG1309	transcriptional regulator
GII88_11070	COG2318	DinB family
GII88_11075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GII88_11080	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GII88_11095	COG1012	belongs to the aldehyde dehydrogenase family
GII88_11100	COG2814	Major facilitator Superfamily
GII88_11115	COG1657	PFAM Prenyltransferase squalene oxidase
GII88_11120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GII88_11135	COG0733	neurotransmitter:sodium symporter activity
GII88_11140	COG0385	Bile acid
GII88_11145	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII88_11150	COG0567	Dehydrogenase, E1 component
GII88_11155	COG4548	von Willebrand factor, type A
GII88_11160	COG0714	Associated with various cellular activities
GII88_11165	COG2032	superoxide dismutase activity
GII88_11170	COG0791	NLP P60 protein
GII88_11170	COG1388	LysM domain
GII88_11180	COG0534	Mate efflux family protein
GII88_11185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GII88_11190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GII88_11200	COG2962	Rard protein
GII88_11210	COG4305	rare lipoprotein A
GII88_11220	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_11225	COG1733	regulation of RNA biosynthetic process
GII88_11230	COG0778	Nitroreductase
GII88_11235	COG0400	carboxylic ester hydrolase activity
GII88_11245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII88_11255	COG0793	Belongs to the peptidase S41A family
GII88_11255	COG3409	Peptidoglycan-binding domain 1 protein
GII88_11260	COG2226	methyltransferase
GII88_11270	COG1876	peptidase activity
GII88_11275	COG0813	purine-nucleoside phosphorylase activity
GII88_11280	COG0701	Predicted permease
GII88_11300	COG0671	phosphoesterase, PA-phosphatase related
GII88_11315	COG4479	Belongs to the UPF0346 family
GII88_11335	COG3331	DNA recombination
GII88_11340	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GII88_11380	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GII88_11410	COG0756	dUTP diphosphatase activity
GII88_11430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII88_11440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII88_11445	COG0270	DNA (cytosine-5-)-methyltransferase activity
GII88_11455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII88_11465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII88_11470	COG1780	Probably involved in ribonucleotide reductase function
GII88_11550	COG3584	3D domain protein
GII88_11555	COG0587	DNA-directed DNA polymerase activity
GII88_11560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GII88_11565	COG0358	DNA primase activity
GII88_11570	COG0305	Participates in initiation and elongation during chromosome replication
GII88_11580	COG2887	Belongs to the helicase family. UvrD subfamily
GII88_11615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GII88_11655	COG1793	dna ligase
GII88_11700	COG4474	Belongs to the UPF0398 family
GII88_11715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GII88_11745	COG0582	viral genome integration into host DNA
GII88_11775	COG1404	Belongs to the peptidase S8 family
GII88_11850	COG3655	Transcriptional regulator
GII88_11975	COG4373	Mu-like prophage FluMu protein gp28
GII88_12070	COG0582	viral genome integration into host DNA
GII88_12125	COG0739	heme binding
GII88_12125	COG0741	lytic transglycosylase activity
GII88_12125	COG1196	nuclear chromosome segregation
GII88_12130	COG1196	nuclear chromosome segregation
GII88_12130	COG0739	heme binding
GII88_12130	COG0741	lytic transglycosylase activity
GII88_12135	COG1196	nuclear chromosome segregation
GII88_12135	COG0741	lytic transglycosylase activity
GII88_12135	COG0739	heme binding
GII88_12145	COG2433	Pfam Transposase IS66
GII88_12155	COG5434	Belongs to the glycosyl hydrolase 28 family
GII88_12160	COG5632	N-Acetylmuramoyl-L-alanine amidase
GII88_12185	COG0457	Tetratricopeptide repeat
GII88_12190	COG2814	Major facilitator Superfamily
GII88_12225	COG5444	nuclease activity
GII88_12230	COG4282	regulation of fungal-type cell wall biogenesis
GII88_12240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GII88_12245	COG1509	lysine 2,3-aminomutase activity
GII88_12250	COG0456	acetyltransferase
GII88_12255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII88_12260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GII88_12265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GII88_12270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GII88_12285	COG0456	acetyltransferase
GII88_12290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GII88_12295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GII88_12300	COG1846	Transcriptional regulator
GII88_12310	COG3706	GGDEF domain
GII88_12315	COG0534	Mate efflux family protein
GII88_12330	COG4698	Protein conserved in bacteria
GII88_12335	COG2755	lipolytic protein G-D-S-L family
GII88_12340	COG1999	signal sequence binding
GII88_12355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GII88_12360	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GII88_12365	COG1272	protein, Hemolysin III
GII88_12370	COG0204	Acyl-transferase
GII88_12375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GII88_12380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GII88_12390	COG2521	methyltransferase
GII88_12390	COG2136	Putative SAM-dependent methyltransferase
GII88_12400	COG0129	dihydroxy-acid dehydratase activity
GII88_12405	COG1413	lyase activity
GII88_12410	COG1418	mRNA catabolic process
GII88_12415	COG0386	Belongs to the glutathione peroxidase family
GII88_12420	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GII88_12425	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GII88_12430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GII88_12440	COG1278	Cold shock
GII88_12460	COG0328	RNA-DNA hybrid ribonuclease activity
GII88_12465	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GII88_12470	COG0328	RNA-DNA hybrid ribonuclease activity
GII88_12480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GII88_12490	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GII88_12500	COG1755	Isoprenylcysteine carboxyl methyltransferase
GII88_12505	COG3424	synthase
GII88_12510	COG0456	acetyltransferase
GII88_12515	COG2233	PERMEase
GII88_12520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GII88_12525	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GII88_12530	COG1199	ATP-dependent helicase activity
GII88_12540	COG0116	Belongs to the methyltransferase superfamily
GII88_12550	COG3599	regulation of cell shape
GII88_12555	COG4474	Belongs to the UPF0398 family
GII88_12565	COG3359	exonuclease
GII88_12570	COG1205	dead DEAH box helicase
GII88_12570	COG1111	helicase
GII88_12575	COG2190	(PTS) system
GII88_12580	COG0071	Belongs to the small heat shock protein (HSP20) family
GII88_12620	COG3331	DNA recombination
GII88_12625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII88_12625	COG4499	WXG100 protein secretion system (Wss), protein YukC
GII88_12635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GII88_12640	COG3935	DnaD domain protein
GII88_12645	COG0017	Asparaginyl-tRNA synthetase
GII88_12650	COG0436	Aminotransferase
GII88_12655	COG5353	protein conserved in bacteria
GII88_12665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GII88_12665	COG1199	ATP-dependent helicase activity
GII88_12670	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GII88_12675	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GII88_12680	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GII88_12695	COG0617	tRNA 3'-terminal CCA addition
GII88_12700	COG0438	transferase activity, transferring glycosyl groups
GII88_12705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GII88_12710	COG1803	Methylglyoxal synthase
GII88_12715	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GII88_12720	COG1694	Mazg nucleotide pyrophosphohydrolase
GII88_12725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII88_12735	COG4347	Protein of unknown function (DUF1405)
GII88_12740	COG2010	Cytochrome c
GII88_12740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GII88_12745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GII88_12750	COG0723	plastoquinol--plastocyanin reductase activity
GII88_12760	COG5582	Belongs to the UPF0302 family
GII88_12765	COG0457	Tetratricopeptide repeat
GII88_12770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GII88_12775	COG0287	Prephenate dehydrogenase
GII88_12780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GII88_12785	COG0159	tryptophan synthase activity
GII88_12790	COG0133	tryptophan synthase activity
GII88_12795	COG0135	phosphoribosylanthranilate isomerase activity
GII88_12800	COG0134	indole-3-glycerol-phosphate synthase activity
GII88_12805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GII88_12810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GII88_12815	COG4401	Chorismate mutase type I
GII88_12820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GII88_12825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GII88_12830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GII88_12835	COG0105	UTP biosynthetic process
GII88_12840	COG0142	geranyltranstransferase activity
GII88_12845	COG2226	methyltransferase
GII88_12850	COG0142	geranyltranstransferase activity
GII88_12865	COG0776	regulation of translation
GII88_12870	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GII88_12890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GII88_12895	COG1160	GTP binding
GII88_12920	COG1304	FMN binding
GII88_12925	COG0539	negative regulation of cytoplasmic translation
GII88_12930	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GII88_12935	COG2959	enzyme of heme biosynthesis
GII88_12940	COG3409	Peptidoglycan-binding domain 1 protein
GII88_12940	COG3773	Cell wall hydrolase
GII88_12945	COG2339	peptidase activity
GII88_12955	COG0492	ferredoxin-NADP+ reductase activity
GII88_12960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GII88_12965	COG4862	establishment of competence for transformation
GII88_12970	COG1408	metallophosphoesterase
GII88_12980	COG1388	LysM domain
GII88_12985	COG1266	CAAX protease self-immunity
GII88_12990	COG0514	ATP-dependent DNA helicase (RecQ)
GII88_12995	COG4955	Helix-turn-helix domain
GII88_13000	COG1141	Ferredoxin
GII88_13005	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GII88_13010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GII88_13015	COG0739	heme binding
GII88_13025	COG1595	DNA-templated transcription, initiation
GII88_13045	COG5002	protein histidine kinase activity
GII88_13050	COG0745	RESPONSE REGULATOR receiver
GII88_13055	COG5002	protein histidine kinase activity
GII88_13060	COG0745	RESPONSE REGULATOR receiver
GII88_13065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GII88_13070	COG1333	cytochrome c biogenesis protein
GII88_13075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII88_13080	COG1187	pseudouridine synthase activity
GII88_13085	COG0700	Nucleoside recognition
GII88_13090	COG2715	membrane protein required for spore maturation
GII88_13095	COG1686	Belongs to the peptidase S11 family
GII88_13105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GII88_13110	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GII88_13120	COG1547	Domain of unknown function (DUF309)
GII88_13125	COG0456	acetyltransferase
GII88_13130	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GII88_13135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GII88_13135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GII88_13140	COG0307	riboflavin synthase, alpha
GII88_13145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GII88_13145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GII88_13170	COG0457	Tetratricopeptide repeat
GII88_13175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GII88_13180	COG4086	secreted protein
GII88_13185	COG4195	phage-related replication protein
GII88_13190	COG0019	diaminopimelate decarboxylase activity
GII88_13200	COG0697	spore germination
GII88_13215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GII88_13250	COG1686	Belongs to the peptidase S11 family
GII88_13255	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GII88_13260	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GII88_13265	COG4974	Belongs to the 'phage' integrase family
GII88_13275	COG0735	belongs to the Fur family
GII88_13280	COG1300	Membrane
GII88_13285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII88_13305	COG2153	protein acetylation
GII88_13310	COG1379	DNA repair
GII88_13315	COG0494	nUDIX hydrolase
GII88_13325	COG1309	transcriptional regulator
GII88_13335	COG0667	Aldo Keto reductase
GII88_13345	COG1073	alpha beta
GII88_13355	COG4918	Iron-sulphur cluster biosynthesis
GII88_13370	COG2329	Antibiotic biosynthesis monooxygenase
GII88_13375	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GII88_13385	COG0747	negative chemotaxis
GII88_13390	COG0601	transmembrane transport
GII88_13400	COG0444	Belongs to the ABC transporter superfamily
GII88_13410	COG0534	Mate efflux family protein
GII88_13425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GII88_13435	COG2211	Major facilitator Superfamily
GII88_13440	COG0346	lactoylglutathione lyase activity
GII88_13445	COG1072	(Pantothenic acid kinase))
GII88_13480	COG4195	phage-related replication protein
GII88_13490	COG0300	oxidoreductase activity
GII88_13495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII88_13500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GII88_13505	COG4187	Peptidase family M20/M25/M40
GII88_13510	COG1902	pentaerythritol trinitrate reductase activity
GII88_13515	COG0596	Alpha beta hydrolase
GII88_13520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GII88_13525	COG1234	tRNA 3'-trailer cleavage
GII88_13530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GII88_13550	COG2188	Transcriptional regulator
GII88_13555	COG2723	6-phospho-beta-galactosidase activity
GII88_13560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII88_13565	COG1447	Phosphotransferase system cellobiose-specific component IIA
GII88_13570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII88_13575	COG1785	Belongs to the alkaline phosphatase family
GII88_13580	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_13585	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GII88_13590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GII88_13600	COG0706	membrane insertase activity
GII88_13605	COG2195	Cleaves the N-terminal amino acid of tripeptides
GII88_13610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GII88_13620	COG4129	membrane
GII88_13625	COG1126	abc transporter atp-binding protein
GII88_13630	COG0765	amino acid transport
GII88_13635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII88_13645	COG1597	lipid kinase activity
GII88_13650	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII88_13655	COG0022	dehydrogenase e1 component
GII88_13660	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GII88_13665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GII88_13670	COG3426	butyrate kinase activity
GII88_13680	COG0280	phosphate acetyltransferase
GII88_13685	COG3829	transcription factor binding
GII88_13685	COG3290	protein histidine kinase activity
GII88_13695	COG0584	glycerophosphoryl diester phosphodiesterase
GII88_13700	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII88_13715	COG1045	serine acetyltransferase
GII88_13725	COG0745	RESPONSE REGULATOR receiver
GII88_13730	COG0750	zinc metalloprotease
GII88_13735	COG0497	DNA recombination
GII88_13740	COG1438	arginine binding
GII88_13745	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GII88_13750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GII88_13755	COG0142	geranyltranstransferase activity
GII88_13760	COG1722	exodeoxyribonuclease VII activity
GII88_13765	COG1570	exodeoxyribonuclease VII activity
GII88_13770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GII88_13775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GII88_13780	COG1302	Protein conserved in bacteria
GII88_13785	COG0439	Biotin carboxylase
GII88_13790	COG0511	ligase activity, forming carbon-carbon bonds
GII88_13830	COG3854	ATPases associated with a variety of cellular activities
GII88_13840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GII88_13845	COG0006	proline dipeptidase activity
GII88_13850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GII88_13860	COG3872	metal-dependent enzyme
GII88_13870	COG1752	Esterase of the alpha-beta hydrolase superfamily
GII88_13875	COG1321	iron dependent repressor
GII88_13880	COG0095	Lipoate-protein ligase
GII88_13885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII88_13890	COG2113	Glycine betaine
GII88_13895	COG4176	ABC-type proline glycine betaine transport system permease component
GII88_13900	COG4175	Glycine betaine
GII88_13900	COG0517	IMP dehydrogenase activity
GII88_13905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GII88_13910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GII88_13915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GII88_13920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GII88_13945	COG0681	Belongs to the peptidase S26 family
GII88_13970	COG4940	Competence protein ComGF
GII88_13980	COG4970	Tfp pilus assembly protein FimT
GII88_13985	COG4537	Required for transformation and DNA binding
GII88_13990	COG1459	type II secretion system
GII88_13995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GII88_14000	COG1366	Belongs to the anti-sigma-factor antagonist family
GII88_14010	COG1393	Belongs to the ArsC family
GII88_14020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII88_14030	COG0011	TIGRFAM Protein of
GII88_14040	COG2866	Carboxypeptidase
GII88_14045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII88_14050	COG1368	sulfuric ester hydrolase activity
GII88_14055	COG1940	carbohydrate kinase activity
GII88_14060	COG4483	Protein conserved in bacteria
GII88_14065	COG0697	spore germination
GII88_14070	COG0457	Tetratricopeptide repeat
GII88_14070	COG0705	Rhomboid family
GII88_14075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GII88_14080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GII88_14085	COG0438	transferase activity, transferring glycosyl groups
GII88_14100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GII88_14105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GII88_14110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GII88_14115	COG0581	inorganic phosphate transmembrane transporter activity
GII88_14120	COG0573	inorganic phosphate transmembrane transporter activity
GII88_14125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GII88_14135	COG0477	Major facilitator Superfamily
GII88_14140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GII88_14145	COG2839	Protein conserved in bacteria
GII88_14150	COG5521	maltodextrose utilization protein MalA
GII88_14155	COG1388	LysM domain
GII88_14160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GII88_14165	COG4709	membrane
GII88_14170	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GII88_14175	COG0735	belongs to the Fur family
GII88_14180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GII88_14185	COG1121	(ABC) transporter
GII88_14190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII88_14200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GII88_14205	COG0513	Belongs to the DEAD box helicase family
GII88_14215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GII88_14220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GII88_14225	COG2384	SAM-dependent methyltransferase
GII88_14275	COG5444	nuclease activity
GII88_14290	COG2010	Cytochrome c
GII88_14295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GII88_14300	COG0358	DNA primase activity
GII88_14305	COG1671	Belongs to the UPF0178 family
GII88_14310	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GII88_14315	COG0517	IMP dehydrogenase activity
GII88_14320	COG0751	glycine-tRNA ligase activity
GII88_14325	COG0752	glycyl-tRNA synthetase alpha subunit
GII88_14330	COG1381	Involved in DNA repair and RecF pathway recombination
GII88_14340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GII88_14345	COG0295	cytidine deaminase activity
GII88_14350	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GII88_14355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GII88_14360	COG1480	7TM receptor with intracellular HD hydrolase
GII88_14365	COG1702	phosphate starvation-inducible protein PhoH
GII88_14370	COG0561	phosphatase activity
GII88_14385	COG4864	UPF0365 protein
GII88_14390	COG1030	water channel activity
GII88_14395	COG1610	YqeY-like protein
GII88_14400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GII88_14405	COG1283	sodium-dependent phosphate transmembrane transporter activity
GII88_14410	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GII88_14415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GII88_14420	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GII88_14425	COG2264	protein methyltransferase activity
GII88_14430	COG0484	heat shock protein binding
GII88_14435	COG0443	Heat shock 70 kDa protein
GII88_14440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GII88_14445	COG1420	regulation of RNA biosynthetic process
GII88_14450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GII88_14455	COG0481	GTPase activity
GII88_14465	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII88_14470	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GII88_14475	COG0268	Binds directly to 16S ribosomal RNA
GII88_14480	COG1466	dna polymerase III delta subunit
GII88_14490	COG2333	competence protein COMEC
GII88_14490	COG0658	competence protein
GII88_14495	COG2131	deaminase
GII88_14500	COG1596	polysaccharide export
GII88_14500	COG1555	photosystem II stabilization
GII88_14505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GII88_14510	COG2226	methyltransferase
GII88_14515	COG0799	negative regulation of ribosome biogenesis
GII88_14520	COG1713	HD superfamily hydrolase involved in NAD metabolism
GII88_14525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GII88_14530	COG1534	Rna-binding protein
GII88_14535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GII88_14540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GII88_14545	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GII88_14555	COG2755	lipolytic protein G-D-S-L family
GII88_14560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII88_14565	COG5609	conserved protein (DUF2294)
GII88_14570	COG3383	formate dehydrogenase (NAD+) activity
GII88_14575	COG2427	Protein of unknown function (DUF1641)
GII88_14605	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII88_14650	COG1136	(ABC) transporter
GII88_14655	COG0577	efflux transmembrane transporter activity
GII88_14740	COG2197	response regulator
GII88_14745	COG4585	Histidine kinase
GII88_14750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII88_14755	COG0730	response to heat
GII88_14760	COG0425	Belongs to the sulfur carrier protein TusA family
GII88_14765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII88_14765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII88_14770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII88_14770	COG0425	Belongs to the sulfur carrier protein TusA family
GII88_14775	COG2210	Belongs to the sulfur carrier protein TusA family
GII88_14780	COG1937	Protein conserved in bacteria
GII88_14825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GII88_14830	COG0113	porphobilinogen synthase activity
GII88_14835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GII88_14840	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GII88_14845	COG1733	regulation of RNA biosynthetic process
GII88_14850	COG3239	Fatty acid desaturase
GII88_14855	COG4585	Histidine kinase
GII88_14860	COG2197	response regulator
GII88_14865	COG0492	ferredoxin-NADP+ reductase activity
GII88_14870	COG0747	negative chemotaxis
GII88_14875	COG0601	transmembrane transport
GII88_14885	COG0444	Belongs to the ABC transporter superfamily
GII88_14890	COG4608	Belongs to the ABC transporter superfamily
GII88_14910	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_14925	COG2124	cytochrome p450
GII88_14930	COG0730	response to heat
GII88_14945	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_14950	COG1621	beta-fructofuranosidase activity
GII88_14955	COG3716	PTS system mannose fructose sorbose family IID component
GII88_14960	COG3715	PTS system
GII88_14965	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_14970	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII88_14975	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GII88_14975	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GII88_15000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GII88_15005	COG0656	L-ascorbic acid biosynthetic process
GII88_15010	COG2814	Major facilitator Superfamily
GII88_15015	COG1733	regulation of RNA biosynthetic process
GII88_15020	COG3340	Belongs to the peptidase S51 family
GII88_15025	COG1587	Uroporphyrinogen-III synthase
GII88_15035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII88_15040	COG0583	DNA-binding transcription factor activity
GII88_15045	COG2814	Major facilitator Superfamily
GII88_15055	COG2124	cytochrome p450
GII88_15055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GII88_15060	COG1309	transcriptional regulator
GII88_15065	COG1404	Belongs to the peptidase S8 family
GII88_15070	COG2226	methyltransferase
GII88_15095	COG0626	cystathionine gamma-synthase activity
GII88_15100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GII88_15105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GII88_15110	COG2226	methyltransferase
GII88_15125	COG0768	penicillin binding
GII88_15130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GII88_15135	COG0572	uridine kinase
GII88_15155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GII88_15160	COG3906	Belongs to the UPF0473 family
GII88_15165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GII88_15170	COG4472	Bacterial protein of unknown function (DUF965)
GII88_15175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GII88_15180	COG0628	permease
GII88_15195	COG3881	PFAM PRC-barrel domain
GII88_15200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GII88_15205	COG0457	Tetratricopeptide repeat
GII88_15210	COG0482	sulfurtransferase activity
GII88_15215	COG1104	cysteine desulfurase activity
GII88_15220	COG1959	2 iron, 2 sulfur cluster binding
GII88_15225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GII88_15230	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GII88_15240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GII88_15245	COG0124	histidyl-tRNA synthetase
GII88_15250	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII88_15250	COG4991	sh3 domain protein
GII88_15250	COG3103	Sh3 type 3 domain protein
GII88_15255	COG1490	D-aminoacyl-tRNA deacylase activity
GII88_15260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GII88_15265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GII88_15270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GII88_15270	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GII88_15275	COG5416	Lipopolysaccharide assembly protein A domain
GII88_15280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GII88_15280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GII88_15290	COG2244	polysaccharide biosynthetic process
GII88_15295	COG2323	membrane
GII88_15305	COG1862	Preprotein translocase
GII88_15310	COG0343	queuine tRNA-ribosyltransferase activity
GII88_15315	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GII88_15325	COG2255	four-way junction helicase activity
GII88_15330	COG0632	four-way junction helicase activity
GII88_15340	COG2112	serine threonine protein kinase
GII88_15350	COG2318	DinB family
GII88_15355	COG4195	phage-related replication protein
GII88_15370	COG0217	transcriptional regulatory protein
GII88_15380	COG1388	LysM domain
GII88_15385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GII88_15390	COG0157	Belongs to the NadC ModD family
GII88_15395	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GII88_15400	COG1104	cysteine desulfurase activity
GII88_15405	COG1827	regulation of RNA biosynthetic process
GII88_15410	COG0077	Prephenate dehydratase
GII88_15415	COG4492	Belongs to the UPF0735 family
GII88_15420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GII88_15425	COG3290	protein histidine kinase activity
GII88_15430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GII88_15435	COG2868	ribosomal protein
GII88_15440	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GII88_15445	COG1994	Peptidase M50
GII88_15450	COG0739	heme binding
GII88_15455	COG3832	glyoxalase III activity
GII88_15460	COG0640	Transcriptional regulator
GII88_15465	COG2894	cell division
GII88_15470	COG0850	regulation of cytokinetic process
GII88_15475	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GII88_15480	COG1792	Involved in formation and maintenance of cell shape
GII88_15485	COG1077	Cell shape determining protein MreB Mrl
GII88_15490	COG2003	Belongs to the UPF0758 family
GII88_15495	COG0424	maF-like protein
GII88_15505	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GII88_15510	COG0285	dihydrofolate synthase activity
GII88_15515	COG0525	valine-tRNA ligase activity
GII88_15525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII88_15530	COG1388	LysM domain
GII88_15535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GII88_15540	COG0113	porphobilinogen synthase activity
GII88_15545	COG1587	Uroporphyrinogen-III synthase
GII88_15550	COG0181	hydroxymethylbilane synthase activity
GII88_15555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GII88_15560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GII88_15570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GII88_15575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GII88_15580	COG0470	DNA polymerase III
GII88_15580	COG1067	ATP-dependent peptidase activity
GII88_15585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GII88_15590	COG0544	peptidyl-prolyl cis-trans isomerase activity
GII88_15595	COG0457	Tetratricopeptide repeat
GII88_15595	COG1477	protein flavinylation
GII88_15600	COG0066	3-isopropylmalate dehydratase activity
GII88_15605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GII88_15610	COG0473	3-isopropylmalate dehydrogenase activity
GII88_15615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GII88_15620	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GII88_15625	COG0440	acetolactate synthase activity
GII88_15630	COG0028	Belongs to the TPP enzyme family
GII88_15635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GII88_15645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GII88_15665	COG5518	Phage portal protein
GII88_15715	COG5444	nuclease activity
GII88_15720	COG0457	Tetratricopeptide repeat
GII88_15740	COG0622	Phosphoesterase
GII88_15745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GII88_15750	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GII88_15755	COG5401	PFAM Sporulation and spore germination
GII88_15760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GII88_15765	COG1846	Transcriptional regulator
GII88_15770	COG2197	response regulator
GII88_15775	COG4221	oxidoreductase activity
GII88_15780	COG0824	Thioesterase
GII88_15785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GII88_15790	COG1053	succinate dehydrogenase
GII88_15795	COG2009	succinate dehydrogenase
GII88_15800	COG1719	4-vinyl reductase, 4VR
GII88_15805	COG0527	aspartate kinase activity
GII88_15810	COG0322	excinuclease ABC activity
GII88_15815	COG3118	belongs to the thioredoxin family
GII88_15820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GII88_15825	COG2086	electron transfer activity
GII88_15830	COG1024	Enoyl-CoA hydratase
GII88_15835	COG1309	transcriptional regulator
GII88_15840	COG0318	PFAM AMP-dependent synthetase and ligase
GII88_15845	COG3766	membrane
GII88_15850	COG1193	negative regulation of DNA recombination
GII88_15855	COG1796	DNA polymerase
GII88_15855	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GII88_15860	COG1286	toxin biosynthetic process
GII88_15865	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GII88_15870	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GII88_15895	COG1137	ATPase activity
GII88_15910	COG0072	phenylalanine-tRNA ligase activity
GII88_15910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII88_15915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GII88_15920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GII88_15930	COG1966	Carbon starvation protein
GII88_15945	COG0395	ABC-type sugar transport system, permease component
GII88_15950	COG1175	transmembrane transport
GII88_15955	COG1653	transport
GII88_15960	COG0371	Dehydrogenase
GII88_15965	COG0235	Class ii aldolase
GII88_15970	COG1069	ribulokinase activity
GII88_15975	COG2160	L-arabinose isomerase activity
GII88_15980	COG3507	Belongs to the glycosyl hydrolase 43 family
GII88_15985	COG1363	Peptidase, m42
GII88_15995	COG3326	Membrane
GII88_16000	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GII88_16005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GII88_16010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GII88_16015	COG1346	cytolysis
GII88_16025	COG3540	Alkaline phosphatase
GII88_16030	COG3279	Response regulator of the LytR AlgR family
GII88_16035	COG3275	phosphorelay sensor kinase activity
GII88_16050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GII88_16060	COG0398	Pfam SNARE associated Golgi protein
GII88_16065	COG1484	DNA-dependent DNA replication
GII88_16070	COG3611	Membrane attachment protein
GII88_16075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GII88_16090	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GII88_16095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GII88_16110	COG0237	dephospho-CoA kinase activity
GII88_16115	COG1971	Probably functions as a manganese efflux pump
GII88_16120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GII88_16125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GII88_16125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GII88_16130	COG5002	protein histidine kinase activity
GII88_16135	COG0745	RESPONSE REGULATOR receiver
GII88_16140	COG0039	L-malate dehydrogenase activity
GII88_16145	COG0538	isocitrate dehydrogenase activity
GII88_16150	COG0372	Belongs to the citrate synthase family
GII88_16155	COG2707	UPF0756 membrane protein
GII88_16160	COG0628	permease
GII88_16165	COG3030	protein affecting phage T7 exclusion by the F plasmid
GII88_16175	COG0205	6-phosphofructokinase activity
GII88_16180	COG0825	malonyl-CoA metabolic process
GII88_16185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GII88_16190	COG0281	malic enzyme
GII88_16195	COG0587	DNA-directed DNA polymerase activity
GII88_16215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GII88_16225	COG4109	DRTGG domain
GII88_16230	COG1695	Transcriptional regulator
GII88_16235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GII88_16240	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_16245	COG0165	Argininosuccinate lyase
GII88_16250	COG0137	argininosuccinate synthase activity
GII88_16255	COG0521	Mo-molybdopterin cofactor biosynthetic process
GII88_16260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GII88_16265	COG0827	DNA restriction-modification system
GII88_16270	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GII88_16275	COG3874	Sporulation protein YtfJ
GII88_16285	COG1714	RDD family
GII88_16290	COG0616	signal peptide processing
GII88_16295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GII88_16300	COG1566	PFAM secretion protein HlyD family protein
GII88_16305	COG0477	Major facilitator Superfamily
GII88_16315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GII88_16325	COG0301	tRNA thio-modification
GII88_16330	COG1104	cysteine desulfurase activity
GII88_16335	COG1114	Component of the transport system for branched-chain amino acids
GII88_16345	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GII88_16350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GII88_16355	COG1309	transcriptional regulator
GII88_16360	COG1956	GAF domain-containing protein
GII88_16365	COG2199	diguanylate cyclase activity
GII88_16365	COG2203	Gaf domain
GII88_16370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GII88_16385	COG3152	Membrane
GII88_16390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GII88_16395	COG1522	sequence-specific DNA binding
GII88_16400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GII88_16405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GII88_16410	COG0454	-acetyltransferase
GII88_16415	COG0517	IMP dehydrogenase activity
GII88_16420	COG0123	including yeast histone deacetylase and acetoin utilization protein
GII88_16425	COG1360	Flagellar Motor Protein
GII88_16430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GII88_16435	COG1609	Transcriptional regulator
GII88_16440	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GII88_16440	COG1605	Chorismate mutase
GII88_16450	COG3118	belongs to the thioredoxin family
GII88_16455	COG4980	gas vesicle protein
GII88_16460	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GII88_16465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GII88_16470	COG1674	ftsk spoiiie
GII88_16475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII88_16480	COG4848	Belongs to the UPF0354 family
GII88_16485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII88_16495	COG1363	Peptidase, m42
GII88_16500	COG5584	Small secreted protein
GII88_16510	COG0281	malic enzyme
GII88_16515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII88_16520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GII88_16530	COG0510	thiamine kinase activity
GII88_16535	COG1523	belongs to the glycosyl hydrolase 13 family
GII88_16540	COG1597	lipid kinase activity
GII88_16550	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GII88_16555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GII88_16570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII88_16575	COG2252	PERMEase
GII88_16580	COG1349	DNA-binding transcription factor activity
GII88_16585	COG1187	pseudouridine synthase activity
GII88_16590	COG2244	polysaccharide biosynthetic process
GII88_16595	COG2081	HI0933 family
GII88_16600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GII88_16610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII88_16625	COG5578	integral membrane protein
GII88_16630	COG0673	inositol 2-dehydrogenase activity
GII88_16635	COG1653	transport
GII88_16640	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GII88_16645	COG4209	transmembrane transport
GII88_16650	COG2207	Transcriptional regulator
GII88_16655	COG1653	transport
GII88_16660	COG0395	ABC-type sugar transport system, permease component
GII88_16665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GII88_16670	COG1073	alpha beta
GII88_16680	COG0583	DNA-binding transcription factor activity
GII88_16685	COG0346	lactoylglutathione lyase activity
GII88_16690	COG0495	leucyl-tRNA aminoacylation
GII88_16700	COG2814	Major facilitator Superfamily
GII88_16710	COG2433	Pfam Transposase IS66
GII88_16715	COG0577	efflux transmembrane transporter activity
GII88_16720	COG1136	(ABC) transporter
GII88_16730	COG1131	(ABC) transporter
GII88_16735	COG1725	Transcriptional regulator
GII88_16745	COG1242	4 iron, 4 sulfur cluster binding
GII88_16750	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GII88_16755	COG1301	dicarboxylic acid transport
GII88_16765	COG2267	carboxylic ester hydrolase activity
GII88_16770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GII88_16775	COG0671	phosphoesterase, PA-phosphatase related
GII88_16780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GII88_16780	COG0438	transferase activity, transferring glycosyl groups
GII88_16785	COG0367	asparagine synthase
GII88_16790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GII88_16795	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GII88_16810	COG1506	peptidase
GII88_16815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GII88_16820	COG1116	anion transmembrane transporter activity
GII88_16825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GII88_16830	COG0494	nUDIX hydrolase
GII88_16840	COG4824	toxin secretion phage lysis holin
GII88_16845	COG0783	Belongs to the Dps family
GII88_16860	COG1854	S-ribosylhomocysteine lyase activity
GII88_16865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GII88_16870	COG0288	reversible hydration of carbon dioxide
GII88_16875	COG0523	cobalamin synthesis protein
GII88_16880	COG0803	Belongs to the bacterial solute-binding protein 9 family
GII88_16885	COG0254	rRNA binding
GII88_16890	COG1271	oxidase subunit
GII88_16895	COG1294	oxidase, subunit
GII88_16910	COG4948	Mandelate Racemase Muconate Lactonizing
GII88_16915	COG0318	PFAM AMP-dependent synthetase and ligase
GII88_16920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GII88_16925	COG0596	Alpha beta hydrolase
GII88_16930	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GII88_16935	COG1169	isochorismate synthase
GII88_16940	COG1575	Belongs to the MenA family. Type 1 subfamily
GII88_16945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GII88_16960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GII88_16965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GII88_16970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GII88_17090	COG1609	Transcriptional regulator
GII88_17095	COG3859	Proton-coupled thiamine transporter YuaJ
GII88_17100	COG3764	Sortase (surface protein transpeptidase)
GII88_17115	COG0457	Tetratricopeptide repeat
GII88_17120	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GII88_17125	COG0569	domain protein
GII88_17130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GII88_17140	COG2318	DinB family
GII88_17150	COG1454	alcohol dehydrogenase
GII88_17160	COG1510	regulation of RNA biosynthetic process
GII88_17170	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GII88_17175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GII88_17180	COG2140	Oxalate decarboxylase
GII88_17220	COG1397	ADP-ribosylglycohydrolase
GII88_17255	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GII88_17265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GII88_17270	COG0726	polysaccharide deacetylase
GII88_17275	COG1408	metallophosphoesterase
GII88_17280	COG1968	undecaprenyl-diphosphatase activity
GII88_17285	COG0628	permease
GII88_17290	COG0673	inositol 2-dehydrogenase activity
GII88_17295	COG0693	protein deglycase activity
GII88_17300	COG0840	transmembrane signaling receptor activity
GII88_17305	COG0840	transmembrane signaling receptor activity
GII88_17310	COG0840	transmembrane signaling receptor activity
GII88_17320	COG2070	2-Nitropropane dioxygenase
GII88_17325	COG0432	Pfam Uncharacterised protein family UPF0047
GII88_17330	COG0366	Alpha amylase catalytic
GII88_17345	COG5297	Belongs to the glycosyl hydrolase family 6
GII88_17350	COG1253	flavin adenine dinucleotide binding
GII88_17355	COG2738	Putative neutral zinc metallopeptidase
GII88_17370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GII88_17380	COG2323	membrane
GII88_17385	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GII88_17395	COG0166	Belongs to the GPI family
GII88_17400	COG1979	alcohol dehydrogenase
GII88_17405	COG2155	Conserved Protein
GII88_17410	COG1098	S1 RNA binding domain
GII88_17415	COG0436	Aminotransferase
GII88_17420	COG1522	sequence-specific DNA binding
GII88_17425	COG2267	carboxylic ester hydrolase activity
GII88_17440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GII88_17455	COG5018	Exonuclease
GII88_17460	COG2814	Major facilitator Superfamily
GII88_17465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII88_17470	COG3011	Protein conserved in bacteria
GII88_17480	COG3290	protein histidine kinase activity
GII88_17485	COG4565	transcriptional regulatory protein
GII88_17495	COG1183	phosphatidylcholine synthase activity
GII88_17500	COG0586	Pfam SNARE associated Golgi protein
GII88_17505	COG0688	phosphatidylethanolamine metabolic process
GII88_17510	COG3493	citrate carrier protein
GII88_17520	COG2111	Na H antiporter
GII88_17520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GII88_17525	COG2111	Na H antiporter
GII88_17530	COG1006	Multisubunit Na H antiporter MnhC subunit
GII88_17535	COG0651	ATP synthesis coupled electron transport
GII88_17540	COG1863	multisubunit Na H antiporter MnhE subunit
GII88_17545	COG2212	antiporter activity
GII88_17550	COG1320	monovalent cation:proton antiporter activity
GII88_17555	COG2050	protein possibly involved in aromatic compounds catabolism
GII88_17560	COG2197	response regulator
GII88_17565	COG4585	Histidine kinase
GII88_17595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GII88_17600	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GII88_17605	COG1335	isochorismatase
GII88_17610	COG5506	Protein of unknown function (DUF1694)
GII88_17625	COG0628	permease
GII88_17630	COG1959	2 iron, 2 sulfur cluster binding
GII88_17645	COG1418	mRNA catabolic process
GII88_17650	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_17660	COG1511	domain protein
GII88_17665	COG0433	COG0433 Predicted ATPase
GII88_17665	COG1674	ftsk spoiiie
GII88_17670	COG4499	WXG100 protein secretion system (Wss), protein YukC
GII88_17675	COG5417	Belongs to the EsaB family
GII88_17680	COG4842	Belongs to the WXG100 family
GII88_17685	COG1115	amino acid carrier protein
GII88_17690	COG2508	Transcriptional regulator
GII88_17690	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GII88_17695	COG0686	Belongs to the AlaDH PNT family
GII88_17705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GII88_17710	COG1268	BioY protein
GII88_17715	COG2056	Na+-H+ antiporter family
GII88_17720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GII88_17725	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GII88_17730	COG3584	3D domain protein
GII88_17740	COG1252	NADH dehydrogenase
GII88_17745	COG0492	ferredoxin-NADP+ reductase activity
GII88_17760	COG0456	acetyltransferase
GII88_17765	COG0316	Belongs to the HesB IscA family
GII88_17770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GII88_17775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GII88_17780	COG4844	belongs to the
GII88_17785	COG1252	NADH dehydrogenase
GII88_17790	COG5646	InterPro IPR014922
GII88_17800	COG0457	Tetratricopeptide repeat
GII88_17805	COG3479	Phenolic acid decarboxylase
GII88_17815	COG4837	Protein of unknown function (DUF1462)
GII88_17820	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GII88_17825	COG4946	Tricorn protease homolog
GII88_17825	COG0823	Involved in the tonB-independent uptake of proteins
GII88_17825	COG1506	peptidase
GII88_17830	COG0083	homoserine kinase activity
GII88_17835	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GII88_17840	COG0460	homoserine dehydrogenase
GII88_17850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII88_17855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GII88_17860	COG0647	UMP catabolic process
GII88_17865	COG2445	Protein of unknown function DUF86
GII88_17870	COG4470	Protein conserved in bacteria
GII88_17885	COG0739	heme binding
GII88_17895	COG0733	neurotransmitter:sodium symporter activity
GII88_17905	COG3377	Domain of unknown function (DUF1805)
GII88_17910	COG0737	Belongs to the 5'-nucleotidase family
GII88_17915	COG0730	response to heat
GII88_17920	COG1801	Protein of unknown function DUF72
GII88_17930	COG3226	Transcriptional regulator
GII88_17940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GII88_17945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII88_17950	COG2508	Transcriptional regulator
GII88_17955	COG2814	Major facilitator Superfamily
GII88_17960	COG1288	antiporter activity
GII88_17965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GII88_17975	COG2356	endonuclease I
GII88_17985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GII88_18000	COG0457	Tetratricopeptide repeat
GII88_18005	COG0719	Fe-S assembly protein
GII88_18010	COG0822	iron-sulfur transferase activity
GII88_18015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GII88_18020	COG0719	Fe-S assembly protein
GII88_18025	COG0396	ATPase activity
GII88_18035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GII88_18040	COG1464	Belongs to the NlpA lipoprotein family
GII88_18045	COG2011	ABC-type metal ion transport system permease component
GII88_18050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GII88_18060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII88_18065	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GII88_18075	COG0509	glycine decarboxylation via glycine cleavage system
GII88_18080	COG1393	Belongs to the ArsC family
GII88_18085	COG1960	acyl-CoA dehydrogenase activity
GII88_18090	COG0183	Belongs to the thiolase family
GII88_18095	COG1024	Enoyl-CoA hydratase
GII88_18095	COG1250	3-hydroxyacyl-CoA dehydrogenase
GII88_18110	COG5577	PFAM Coat F domain
GII88_18125	COG1120	ATPase activity
GII88_18130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII88_18135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII88_18140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII88_18155	COG1686	Belongs to the peptidase S11 family
GII88_18160	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_18165	COG0783	Belongs to the Dps family
GII88_18170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII88_18175	COG0745	RESPONSE REGULATOR receiver
GII88_18180	COG2770	Histidine kinase
GII88_18180	COG2205	protein histidine kinase activity
GII88_18185	COG1309	transcriptional regulator
GII88_18190	COG0114	fumarate hydratase activity
GII88_18200	COG0697	spore germination
GII88_18205	COG0814	amino acid
GII88_18220	COG2197	response regulator
GII88_18225	COG4585	Histidine kinase
GII88_18230	COG4758	membrane
GII88_18240	COG1842	Phage shock protein A
GII88_18245	COG4758	membrane
GII88_18250	COG4677	pectinesterase activity
GII88_18255	COG2096	Adenosyltransferase
GII88_18260	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_18275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GII88_18280	COG1120	ATPase activity
GII88_18285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII88_18290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII88_18295	COG1802	Transcriptional regulator
GII88_18300	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_18305	COG2258	MOSC domain
GII88_18310	COG0583	DNA-binding transcription factor activity
GII88_18320	COG2721	sulfolactate sulfo-lyase activity
GII88_18325	COG0246	Mannitol dehydrogenase
GII88_18330	COG1609	Transcriptional regulator
GII88_18335	COG2211	Major facilitator Superfamily
GII88_18340	COG1904	glucuronate isomerase
GII88_18345	COG2205	protein histidine kinase activity
GII88_18350	COG0745	RESPONSE REGULATOR receiver
GII88_18355	COG1120	ATPase activity
GII88_18360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII88_18365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII88_18370	COG0531	amino acid
GII88_18380	COG1988	membrane-bound metal-dependent
GII88_18385	COG1368	sulfuric ester hydrolase activity
GII88_18390	COG2814	Major facilitator Superfamily
GII88_18395	COG0656	L-ascorbic acid biosynthetic process
GII88_18400	COG1940	carbohydrate kinase activity
GII88_18405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GII88_18415	COG3973	AAA domain
GII88_18420	COG2860	membrane
GII88_18425	COG0456	acetyltransferase
GII88_18425	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GII88_18430	COG0456	acetyltransferase
GII88_18435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GII88_18440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GII88_18445	COG2217	Heavy metal translocating P-type atpase
GII88_18450	COG1653	transport
GII88_18455	COG1175	transmembrane transport
GII88_18460	COG0395	ABC-type sugar transport system, permease component
GII88_18465	COG1501	Belongs to the glycosyl hydrolase 31 family
GII88_18470	COG1472	Belongs to the glycosyl hydrolase 3 family
GII88_18475	COG1121	(ABC) transporter
GII88_18480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GII88_18485	COG0803	Belongs to the bacterial solute-binding protein 9 family
GII88_18505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII88_18505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII88_18505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII88_18520	COG2217	Heavy metal translocating P-type atpase
GII88_18525	COG2608	mercury ion transmembrane transporter activity
GII88_18530	COG1937	Protein conserved in bacteria
GII88_18535	COG0693	protein deglycase activity
GII88_18540	COG1349	DNA-binding transcription factor activity
GII88_18545	COG1070	Carbohydrate kinase
GII88_18550	COG4952	isomerase
GII88_18560	COG3347	Dehydrogenase
GII88_18560	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_18565	COG2814	Major facilitator Superfamily
GII88_18570	COG2814	Major facilitator Superfamily
GII88_18580	COG2124	cytochrome p450
GII88_18590	COG1846	Transcriptional regulator
GII88_18600	COG0673	inositol 2-dehydrogenase activity
GII88_18605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GII88_18620	COG1191	sigma factor activity
GII88_18630	COG2140	Oxalate decarboxylase
GII88_18660	COG5444	nuclease activity
GII88_18675	COG2323	membrane
GII88_18680	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GII88_18685	COG0662	Cupin 2, conserved barrel domain protein
GII88_18725	COG1705	Flagellar rod assembly protein muramidase FlgJ
GII88_18735	COG3953	SLT domain
GII88_18735	COG5280	Phage tail tape measure protein TP901
GII88_18795	COG4626	Terminase
GII88_18795	COG1802	Transcriptional regulator
GII88_18930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GII88_18935	COG0557	exoribonuclease II activity
GII88_18940	COG1647	Serine aminopeptidase, S33
GII88_18945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GII88_18950	COG2002	toxin-antitoxin pair type II binding
GII88_18955	COG1476	TRANSCRIPTIONal
GII88_18960	COG1396	sequence-specific DNA binding
GII88_18965	COG1396	sequence-specific DNA binding
GII88_18970	COG1174	glycine betaine transport
GII88_18975	COG1732	Glycine betaine
GII88_18980	COG1174	glycine betaine transport
GII88_18985	COG1125	glycine betaine transport
GII88_18985	COG0517	IMP dehydrogenase activity
GII88_18990	COG1510	regulation of RNA biosynthetic process
GII88_18995	COG2095	MarC family integral membrane protein
GII88_19005	COG4640	response to antibiotic
GII88_19015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII88_19025	COG0693	protein deglycase activity
GII88_19030	COG0148	phosphopyruvate hydratase activity
GII88_19035	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GII88_19040	COG0149	triose-phosphate isomerase activity
GII88_19045	COG0126	phosphoglycerate kinase activity
GII88_19050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GII88_19055	COG2390	Transcriptional regulator
GII88_19060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII88_19065	COG1113	amino acid transport
GII88_19085	COG1556	Lactate utilization protein
GII88_19090	COG1139	Iron-sulfur cluster binding protein
GII88_19095	COG0247	lactate metabolic process
GII88_19100	COG2186	Transcriptional regulator
GII88_19105	COG1620	l-lactate permease
GII88_19110	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GII88_19120	COG5039	Polysaccharide pyruvyl transferase
GII88_19125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GII88_19130	COG0110	maltose O-acetyltransferase activity
GII88_19135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GII88_19140	COG2244	polysaccharide biosynthetic process
GII88_19145	COG1216	Glycosyl transferase, family 2
GII88_19150	COG5039	Polysaccharide pyruvyl transferase
GII88_19155	COG1216	Glycosyl transferase, family 2
GII88_19165	COG0438	transferase activity, transferring glycosyl groups
GII88_19170	COG1215	transferase activity, transferring glycosyl groups
GII88_19175	COG0438	transferase activity, transferring glycosyl groups
GII88_19180	COG1086	Polysaccharide biosynthesis protein
GII88_19185	COG0489	protein tyrosine kinase activity
GII88_19190	COG3944	biosynthesis protein
GII88_19195	COG1396	sequence-specific DNA binding
GII88_19200	COG2249	NAD(P)H dehydrogenase (quinone) activity
GII88_19205	COG2271	Major facilitator Superfamily
GII88_19215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GII88_19230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GII88_19240	COG1733	regulation of RNA biosynthetic process
GII88_19245	COG1902	pentaerythritol trinitrate reductase activity
GII88_19250	COG1621	beta-fructofuranosidase activity
GII88_19255	COG1621	beta-fructofuranosidase activity
GII88_19270	COG0740	serine-type endopeptidase activity
GII88_19275	COG1611	Belongs to the LOG family
GII88_19280	COG1694	Mazg nucleotide pyrophosphohydrolase
GII88_19285	COG1078	dGTPase activity
GII88_19290	COG0659	secondary active sulfate transmembrane transporter activity
GII88_19295	COG0288	reversible hydration of carbon dioxide
GII88_19300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GII88_19310	COG0640	Transcriptional regulator
GII88_19320	COG2732	(Barnase) inhibitor
GII88_19325	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GII88_19330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII88_19335	COG1481	regulation of sporulation
GII88_19340	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GII88_19345	COG1660	Displays ATPase and GTPase activities
GII88_19350	COG1051	belongs to the nudix hydrolase family
GII88_19360	COG0492	ferredoxin-NADP+ reductase activity
GII88_19365	COG0457	Tetratricopeptide repeat
GII88_19370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII88_19375	COG0140	phosphoribosyl-ATP diphosphatase activity
GII88_19375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GII88_19380	COG0107	imidazoleglycerol-phosphate synthase activity
GII88_19385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GII88_19390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GII88_19395	COG0131	Imidazoleglycerol-phosphate dehydratase
GII88_19400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GII88_19405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GII88_19410	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GII88_19415	COG4990	cell redox homeostasis
GII88_19420	COG5297	Belongs to the glycosyl hydrolase family 6
GII88_19425	COG0110	maltose O-acetyltransferase activity
GII88_19430	COG0546	phosphoglycolate phosphatase activity
GII88_19435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GII88_19440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GII88_19445	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GII88_19450	COG1846	Transcriptional regulator
GII88_19455	COG2814	Major facilitator Superfamily
GII88_19460	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GII88_19465	COG1950	PFAM Membrane protein of
GII88_19470	COG1983	PspC domain protein
GII88_19475	COG3595	metallopeptidase activity
GII88_19500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GII88_19505	COG0556	nucleotide-excision repair
GII88_19510	COG4897	Protein conserved in bacteria
GII88_19520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII88_19530	COG3409	Peptidoglycan-binding domain 1 protein
GII88_19530	COG0793	Belongs to the peptidase S41A family
GII88_19535	COG0473	3-isopropylmalate dehydrogenase activity
GII88_19540	COG0791	NLP P60 protein
GII88_19540	COG3883	PFAM NLP P60 protein
GII88_19545	COG2177	Part of the ABC transporter FtsEX involved in
GII88_19550	COG2884	Cell division ATP-binding protein ftsE
GII88_19555	COG2010	Cytochrome c
GII88_19560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII88_19570	COG0653	protein targeting
GII88_19575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GII88_19590	COG1516	flagellar protein fliS
GII88_19595	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GII88_19600	COG1334	flagellar protein FlaG
GII88_19605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GII88_19610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GII88_19615	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GII88_19625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GII88_19630	COG4786	Flagellar basal body rod
GII88_19630	COG1256	bacterial-type flagellum assembly
GII88_19635	COG3418	PFAM FlgN family protein
GII88_19640	COG2747	anti-sigma28 factor FlgM
GII88_19650	COG1040	competence protein
GII88_19660	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GII88_19665	COG1307	EDD domain protein, DegV family
GII88_19670	COG2197	response regulator
GII88_19675	COG4585	Histidine kinase
GII88_19680	COG1739	Uncharacterized protein family UPF0029
GII88_19685	COG1316	TRANSCRIPTIONal
GII88_19695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GII88_19700	COG0438	transferase activity, transferring glycosyl groups
GII88_19705	COG1215	transferase activity, transferring glycosyl groups
GII88_19710	COG3206	protein involved in exopolysaccharide biosynthesis
GII88_19715	COG3307	-O-antigen
GII88_19720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GII88_19725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GII88_19730	COG0297	glycogen (starch) synthase activity
GII88_19730	COG0438	transferase activity, transferring glycosyl groups
GII88_19735	COG2244	polysaccharide biosynthetic process
GII88_19745	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII88_19745	COG2247	cell wall binding repeat
GII88_19750	COG2385	sporulation resulting in formation of a cellular spore
GII88_19750	COG2247	cell wall binding repeat
GII88_19760	COG1316	TRANSCRIPTIONal
GII88_19765	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GII88_19775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GII88_19780	COG1134	teichoic acid transport
GII88_19785	COG1682	transport, permease protein
GII88_19790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GII88_19790	COG0463	Glycosyl transferase, family 2
GII88_19795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GII88_19800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GII88_19805	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GII88_19810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GII88_19815	COG4193	domain, Protein
GII88_19820	COG1482	cell wall glycoprotein biosynthetic process
GII88_19840	COG0800	Aldolase
GII88_19845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII88_19850	COG1609	Transcriptional regulator
GII88_19855	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GII88_19860	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_19865	COG1063	alcohol dehydrogenase
GII88_19870	COG2814	Major facilitator Superfamily
GII88_19875	COG1316	TRANSCRIPTIONal
GII88_19880	COG0561	phosphatase activity
GII88_19885	COG0791	NLP P60 protein
GII88_19890	COG2843	Capsule synthesis protein
GII88_19900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GII88_19905	COG1609	Transcriptional regulator
GII88_19910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII88_19915	COG1869	D-ribose catabolic process
GII88_19920	COG1129	ABC transporter
GII88_19925	COG1172	Belongs to the binding-protein-dependent transport system permease family
GII88_19930	COG1879	ABC-type sugar transport system periplasmic component
GII88_19940	COG3527	Alpha-acetolactate decarboxylase
GII88_19945	COG0028	Belongs to the TPP enzyme family
GII88_19950	COG0583	DNA-binding transcription factor activity
GII88_19960	COG0405	Gamma-glutamyltransferase
GII88_19965	COG1522	sequence-specific DNA binding
GII88_19970	COG2059	Chromate
GII88_19975	COG2059	Chromate
GII88_19980	COG4464	protein tyrosine phosphatase activity
GII88_19985	COG3944	biosynthesis protein
GII88_19995	COG4715	Zinc finger, swim domain protein
GII88_20000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GII88_20005	COG0561	phosphatase activity
GII88_20010	COG1349	DNA-binding transcription factor activity
GII88_20020	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_20030	COG3732	PTS system glucitol sorbitol-specific
GII88_20050	COG0629	single-stranded DNA binding
GII88_20065	COG1970	mechanosensitive ion channel activity
GII88_20070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GII88_20075	COG4786	Flagellar basal body rod
GII88_20080	COG4786	Flagellar basal body rod
GII88_20085	COG1077	Cell shape determining protein MreB Mrl
GII88_20090	COG1609	Transcriptional regulator
GII88_20100	COG1846	Transcriptional regulator
GII88_20105	COG2814	Major facilitator Superfamily
GII88_20110	COG0671	phosphoesterase, PA-phosphatase related
GII88_20115	COG1227	inorganic diphosphatase activity
GII88_20120	COG3546	catalase activity
GII88_20125	COG3361	conserved protein (COG2071)
GII88_20130	COG0517	IMP dehydrogenase activity
GII88_20135	COG0598	Magnesium transport protein CorA
GII88_20140	COG1253	flavin adenine dinucleotide binding
GII88_20145	COG0004	ammonium transporteR
GII88_20150	COG0347	Belongs to the P(II) protein family
GII88_20155	COG0740	serine-type endopeptidase activity
GII88_20165	COG0739	heme binding
GII88_20170	COG1247	-acetyltransferase
GII88_20180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GII88_20190	COG0477	Major facilitator Superfamily
GII88_20195	COG3251	PFAM MbtH domain protein
GII88_20200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII88_20205	COG1535	isochorismatase
GII88_20205	COG3433	isochorismatase activity
GII88_20210	COG1021	2,3-dihydroxybenzoate-AMP ligase
GII88_20215	COG1169	isochorismate synthase
GII88_20220	COG1028	Short-chain dehydrogenase reductase Sdr
GII88_20225	COG2819	hydrolase of the alpha beta superfamily
GII88_20230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII88_20235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII88_20240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII88_20245	COG2207	Transcriptional regulator
GII88_20245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII88_20255	COG2910	NAD(P)H-binding
GII88_20260	COG1959	2 iron, 2 sulfur cluster binding
GII88_20270	COG1994	Peptidase M50
GII88_20275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GII88_20280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GII88_20290	COG3383	formate dehydrogenase (NAD+) activity
GII88_20295	COG2304	oxidoreductase activity
GII88_20300	COG2304	oxidoreductase activity
GII88_20305	COG2385	sporulation resulting in formation of a cellular spore
GII88_20310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GII88_20320	COG4836	Membrane
GII88_20325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GII88_20330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GII88_20335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GII88_20340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GII88_20345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GII88_20350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GII88_20355	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GII88_20375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GII88_20380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GII88_20385	COG4475	Protein of unknown function (DUF436)
GII88_20390	COG0698	ribose 5-phosphate isomerase
GII88_20395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GII88_20400	COG1971	Probably functions as a manganese efflux pump
GII88_20405	COG0009	L-threonylcarbamoyladenylate synthase
GII88_20410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GII88_20420	COG0738	Major facilitator superfamily
GII88_20425	COG0673	inositol 2-dehydrogenase activity
GII88_20430	COG0561	phosphatase activity
GII88_20435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GII88_20440	COG1609	Transcriptional regulator
GII88_20445	COG2890	protein-(glutamine-N5) methyltransferase activity
GII88_20450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GII88_20455	COG0346	lactoylglutathione lyase activity
GII88_20460	COG0789	Transcriptional regulator
GII88_20465	COG0679	Auxin Efflux Carrier
GII88_20470	COG0281	malic enzyme
GII88_20475	COG1435	thymidine kinase activity
GII88_20480	COG0254	rRNA binding
GII88_20485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GII88_20490	COG1494	fructose-1,6-bisphosphatase
GII88_20495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GII88_20500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GII88_20505	COG0191	fructose-bisphosphate aldolase activity
GII88_20510	COG2204	response regulator
GII88_20515	COG4821	SIS domain
GII88_20520	COG0504	CTP synthase activity
GII88_20525	COG3343	RNA polymerase activity
GII88_20530	COG1960	acyl-CoA dehydrogenase activity
GII88_20535	COG1960	acyl-CoA dehydrogenase activity
GII88_20540	COG1250	3-hydroxyacyl-CoA dehydrogenase
GII88_20545	COG0183	Belongs to the thiolase family
GII88_20550	COG0247	lactate metabolic process
GII88_20550	COG2181	nitrate reductase activity
GII88_20555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GII88_20570	COG0018	arginyl-trna synthetase
GII88_20575	COG4506	Protein conserved in bacteria
GII88_20580	COG0010	Belongs to the arginase family
GII88_20585	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GII88_20600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII88_20610	COG1994	Peptidase M50
GII88_20615	COG1942	4-Oxalocrotonate Tautomerase
GII88_20625	COG3465	dGTPase activity
GII88_20630	COG1078	dGTPase activity
GII88_20635	COG4844	belongs to the
GII88_20660	COG2814	Major facilitator Superfamily
GII88_20685	COG1414	Transcriptional regulator
GII88_20695	COG0280	phosphate acetyltransferase
GII88_20715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GII88_20735	COG1131	(ABC) transporter
GII88_20750	COG2363	Small membrane protein
GII88_20755	COG2233	PERMEase
GII88_20765	COG1012	belongs to the aldehyde dehydrogenase family
GII88_20770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GII88_20775	COG1216	Glycosyl transferase, family 2
GII88_20780	COG0351	phosphomethylpyrimidine kinase
GII88_20790	COG1621	beta-fructofuranosidase activity
GII88_20795	COG1263	PTS System
GII88_20795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_20800	COG3711	transcriptional antiterminator
GII88_20810	COG1404	Belongs to the peptidase S8 family
GII88_20820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII88_20825	COG0778	Nitroreductase
GII88_20830	COG1473	amidohydrolase
GII88_20840	COG0772	Belongs to the SEDS family
GII88_20865	COG0456	acetyltransferase
GII88_20900	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GII88_20910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GII88_20915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GII88_20920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GII88_20940	COG3162	membrane
GII88_20945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII88_20950	COG1070	Carbohydrate kinase
GII88_20955	COG2115	Belongs to the xylose isomerase family
GII88_20965	COG0352	thiamine-phosphate diphosphorylase activity
GII88_20970	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GII88_20975	COG0583	DNA-binding transcription factor activity
GII88_20990	COG1380	Effector of murein hydrolase LrgA
GII88_20995	COG1346	cytolysis
GII88_21005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII88_21010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GII88_21015	COG0346	lactoylglutathione lyase activity
GII88_21020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GII88_21025	COG1442	glycosyl transferase family 8
GII88_21035	COG4585	Histidine kinase
GII88_21040	COG2197	response regulator
GII88_21045	COG2409	Drug exporters of the RND superfamily
GII88_21050	COG5522	Integral membrane protein (intg_mem_TP0381)
GII88_21055	COG2271	Major facilitator Superfamily
GII88_21060	COG4948	Mandelate Racemase Muconate Lactonizing
GII88_21065	COG0800	Aldolase
GII88_21070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII88_21080	COG2234	aminopeptidase activity
GII88_21085	COG0477	Major facilitator Superfamily
GII88_21095	COG2357	RelA SpoT domain protein
GII88_21110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII88_21115	COG1696	Membrane protein involved in D-alanine export
GII88_21120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII88_21125	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GII88_21130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GII88_21135	COG2814	Major facilitator Superfamily
GII88_21140	COG1486	melibiose metabolic process
GII88_21145	COG1447	Phosphotransferase system cellobiose-specific component IIA
GII88_21150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII88_21155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII88_21160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII88_21160	COG3711	transcriptional antiterminator
GII88_21165	COG2094	Belongs to the DNA glycosylase MPG family
GII88_21175	COG0372	Belongs to the citrate synthase family
GII88_21180	COG2079	MmgE PrpD family protein
GII88_21185	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GII88_21200	COG1132	(ABC) transporter
GII88_21205	COG2755	lipolytic protein G-D-S-L family
GII88_21220	COG2814	Major facilitator Superfamily
GII88_21225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GII88_21230	COG1131	(ABC) transporter
GII88_21250	COG1595	DNA-templated transcription, initiation
GII88_21255	COG2814	Major facilitator Superfamily
GII88_21260	COG0753	catalase activity
GII88_21265	COG0753	catalase activity
GII88_21270	COG0735	belongs to the Fur family
GII88_21280	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GII88_21285	COG1131	(ABC) transporter
GII88_21300	COG1131	(ABC) transporter
GII88_21350	COG3866	Pectate lyase
GII88_21355	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GII88_21360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GII88_21365	COG4988	ABC transporter
GII88_21370	COG1294	oxidase, subunit
GII88_21375	COG1271	oxidase subunit
GII88_21385	COG2116	formate transmembrane transporter activity
GII88_21395	COG0281	malic enzyme
GII88_21400	COG1757	Na H antiporter
GII88_21405	COG1027	Aspartate ammonia-lyase
GII88_21410	COG0252	asparaginase activity
GII88_21415	COG1396	sequence-specific DNA binding
GII88_21420	COG2706	6-phosphogluconolactonase activity
GII88_21425	COG0745	RESPONSE REGULATOR receiver
GII88_21430	COG2205	protein histidine kinase activity
GII88_21440	COG1136	(ABC) transporter
GII88_21445	COG0577	efflux transmembrane transporter activity
GII88_21450	COG5294	Protein conserved in bacteria
GII88_21460	COG0726	polysaccharide deacetylase
GII88_21465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII88_21475	COG3493	citrate carrier protein
GII88_21480	COG0584	glycerophosphoryl diester phosphodiesterase
GII88_21495	COG1368	sulfuric ester hydrolase activity
GII88_21505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII88_21520	COG2235	arginine
GII88_21525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GII88_21535	COG0549	Belongs to the carbamate kinase family
GII88_21550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII88_21560	COG1595	DNA-templated transcription, initiation
GII88_21585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GII88_21590	COG2195	Cleaves the N-terminal amino acid of tripeptides
GII88_21600	COG1621	beta-fructofuranosidase activity
GII88_21605	COG2223	nitrite transmembrane transporter activity
GII88_21610	COG1609	Transcriptional regulator
GII88_21625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GII88_21630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GII88_21635	COG0463	Glycosyl transferase, family 2
GII88_21640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GII88_21665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GII88_21680	COG2723	6-phospho-beta-galactosidase activity
GII88_21685	COG1263	PTS System
GII88_21685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_21685	COG2190	(PTS) system
GII88_21690	COG3711	transcriptional antiterminator
GII88_21695	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GII88_21700	COG1122	ATPase activity
GII88_21705	COG4721	ABC-type cobalt transport system, permease component
GII88_21710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GII88_21715	COG2224	Isocitrate lyase
GII88_21720	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GII88_21730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GII88_21735	COG0577	efflux transmembrane transporter activity
GII88_21740	COG1136	(ABC) transporter
GII88_21745	COG2205	protein histidine kinase activity
GII88_21750	COG0745	RESPONSE REGULATOR receiver
GII88_21755	COG2723	6-phospho-beta-galactosidase activity
GII88_21760	COG1263	PTS System
GII88_21760	COG2190	(PTS) system
GII88_21760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_21770	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GII88_21775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GII88_21780	COG3507	Belongs to the glycosyl hydrolase 43 family
GII88_21785	COG0513	Belongs to the DEAD box helicase family
GII88_21815	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GII88_21820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GII88_21825	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GII88_21830	COG2390	Transcriptional regulator
GII88_21840	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GII88_21845	COG3706	GGDEF domain
GII88_21850	COG5298	Protein conserved in bacteria
GII88_21855	COG1215	transferase activity, transferring glycosyl groups
GII88_21865	COG3977	Valine--pyruvate aminotransferase
GII88_21880	COG1181	Belongs to the D-alanine--D-alanine ligase family
GII88_21890	COG0191	fructose-bisphosphate aldolase activity
GII88_21895	COG1082	Xylose isomerase domain protein TIM barrel
GII88_21900	COG1082	Xylose isomerase domain protein TIM barrel
GII88_21905	COG0673	inositol 2-dehydrogenase activity
GII88_21910	COG2814	Major facilitator Superfamily
GII88_21915	COG1082	Xylose isomerase domain protein TIM barrel
GII88_21920	COG3962	Belongs to the TPP enzyme family
GII88_21925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII88_21930	COG3718	enzyme involved in inositol metabolism
GII88_21935	COG1012	belongs to the aldehyde dehydrogenase family
GII88_21940	COG1349	DNA-binding transcription factor activity
GII88_21945	COG0667	Aldo Keto reductase
GII88_21950	COG0584	glycerophosphoryl diester phosphodiesterase
GII88_21955	COG2271	Major facilitator Superfamily
GII88_21960	COG0326	Molecular chaperone. Has ATPase activity
GII88_21965	COG0488	(ABC) transporter
GII88_21990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII88_22020	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GII88_22025	COG0577	efflux transmembrane transporter activity
GII88_22030	COG1136	(ABC) transporter
GII88_22035	COG2205	protein histidine kinase activity
GII88_22040	COG0745	RESPONSE REGULATOR receiver
GII88_22050	COG5278	phosphoserine phosphatase activity
GII88_22050	COG0840	transmembrane signaling receptor activity
GII88_22055	COG1115	amino acid carrier protein
GII88_22060	COG0686	Belongs to the AlaDH PNT family
GII88_22065	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GII88_22070	COG1874	Beta-galactosidase
GII88_22075	COG3833	ABC-type maltose transport systems, permease component
GII88_22080	COG1175	transmembrane transport
GII88_22085	COG2182	Extracellular solute-binding protein
GII88_22090	COG1609	Transcriptional regulator
GII88_22100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GII88_22105	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GII88_22110	COG1940	carbohydrate kinase activity
GII88_22135	COG1454	alcohol dehydrogenase
GII88_22135	COG1012	belongs to the aldehyde dehydrogenase family
GII88_22140	COG0450	alkyl hydroperoxide reductase
GII88_22145	COG3634	alkyl hydroperoxide reductase activity
GII88_22170	COG1131	(ABC) transporter
GII88_22175	COG0842	Transport permease protein
GII88_22185	COG2197	response regulator
GII88_22210	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GII88_22225	COG0456	acetyltransferase
GII88_22240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII88_22245	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GII88_22250	COG4853	Protein conserved in bacteria
GII88_22255	COG4863	YycH protein
GII88_22260	COG5002	protein histidine kinase activity
GII88_22265	COG0745	RESPONSE REGULATOR receiver
GII88_22290	COG1051	belongs to the nudix hydrolase family
GII88_22295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GII88_22305	COG0305	Participates in initiation and elongation during chromosome replication
GII88_22320	COG3093	addiction module antidote protein HigA
GII88_22325	COG2807	transmembrane transport
GII88_22330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GII88_22335	COG0363	glucosamine-6-phosphate deaminase activity
GII88_22345	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GII88_22350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII88_22350	COG1263	PTS System
GII88_22355	COG0359	binds to the 23S rRNA
GII88_22360	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GII88_22365	COG4241	membrane
GII88_22370	COG5577	PFAM Coat F domain
GII88_22375	COG0589	response to stress
GII88_22380	COG0659	secondary active sulfate transmembrane transporter activity
GII88_22385	COG2271	Major facilitator Superfamily
GII88_22390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GII88_22395	COG0629	single-stranded DNA binding
GII88_22400	COG0360	Binds together with S18 to 16S ribosomal RNA
GII88_22405	COG0012	GTP binding
GII88_22415	COG4481	Protein conserved in bacteria
GII88_22420	COG3949	Membrane
GII88_22430	COG1475	DNA binding
GII88_22435	COG1192	Involved in chromosome partitioning
GII88_22440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GII88_22450	COG1475	DNA binding
GII88_22455	COG0357	Ribosomal RNA small subunit methyltransferase G
GII88_22460	COG0445	tRNA wobble uridine modification
GII88_22465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GII88_22470	COG1847	R3H domain protein
GII88_22475	COG0706	membrane insertase activity
GII88_22480	COG0594	ribonuclease P activity
GII88_22485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GII88_22505	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GII88_22530	COG0457	Tetratricopeptide repeat