locus-tag class description B37_00010 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj B37_00012 ENOG41068G1 B37_00019 ENOG4107EV6 Inherit from COG: YD repeat protein B37_00027 ENOG41073R8 VanW family B37_00030 ENOG4108RAV Conserved protein B37_00031 ENOG4108X07 Tetr family transcriptional regulator B37_00032 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B37_00034 ENOG4105K78 MarR family Transcriptional regulator B37_00035 ENOG4108VHC Short-chain dehydrogenase reductase Sdr B37_00036 ENOG4105EBR Carboxylesterase B37_00038 ENOG41087YS Phage shock protein A B37_00039 ENOG4105DQX Zinc finger domain B37_00040 ENOG4108WV1 Pfam:DUF477 B37_00043 ENOG4108NGU Transcriptional regulator B37_00044 ENOG4105N14 lysine exporter protein LysE YggA B37_00046 ENOG4105CNI cell division protein FtsW B37_00047 ENOG4105CNI cell division protein FtsW B37_00051 ENOG4108ZJ4 polysaccharide deacetylase B37_00052 ENOG4105E5K Alpha-amylase B37_00053 ENOG4105FKQ transcriptional regulator B37_00054 ENOG4108IUK alpha amylase, catalytic B37_00055 ENOG4107FKK extracellular solute-binding protein family 1 B37_00056 ENOG4105D56 permease protein B37_00057 ENOG4105EG2 ABC transporter, permease B37_00060 ENOG4105CG3 alpha amylase, catalytic region B37_00061 ENOG4107URF beta-phospho-glucomutase B37_00062 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B37_00063 ENOG4105GVJ transcriptional regulator B37_00074 ENOG4108W3Q Transcriptional regulator B37_00075 ENOG4107STQ Multicopper oxidase B37_00079 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B37_00082 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) B37_00083 ENOG4105C7N Xanthine uracil vitamin C permease B37_00086 ENOG4108U5N UPF0316 protein B37_00088 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) B37_00089 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit B37_00090 ENOG4105C83 adenylosuccinate lyase B37_00091 ENOG4105C8V SAICAR synthetase B37_00092 ENOG4105VR9 phosphoribosylformylglycinamidine synthase B37_00094 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii B37_00096 ENOG4105CXB phosphoribosylaminoimidazole synthetase B37_00097 ENOG4108V3E phosphoribosylglycinamide formyltransferase B37_00098 ENOG4105DC1 bifunctional purine biosynthesis protein purh B37_00099 ENOG4105C12 Phosphoribosylglycinamide synthetase B37_00101 ENOG4106A3M Cytochrome p-450 B37_00107 ENOG4108R5T secreted protein B37_00108 ENOG4105KGF protein, YerC YecD B37_00110 ENOG4105C4R Atp-dependent dna helicase B37_00111 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) B37_00113 ENOG4108M21 B37_00115 ENOG4105MUZ Protein of unknown function DUF2620 B37_00116 ENOG4106M0N transport system permease protein B37_00117 ENOG41080QX K07048 phosphotriesterase-related protein B37_00118 ENOG4106PKC pyridoxal phosphate binding B37_00119 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) B37_00120 ENOG4108626 Racemase B37_00121 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) B37_00122 ENOG4105KT7 mgtC SapB transporter B37_00123 ENOG4105CK7 Sodium proline symporter B37_00124 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) B37_00125 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B37_00126 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) B37_00129 ENOG4105D3P Mannan endo-1,4-beta-mannosidase B37_00130 ENOG4108IG5 Transcriptional regulator B37_00133 ENOG4105D9U N-acetyltransferase B37_00135 ENOG4105CBD Diacylglycerol kinase B37_00136 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B37_00143 ENOG4105F5P DNA-damage-inducible protein d B37_00145 ENOG4105DZR Type I site-specific deoxyribonuclease B37_00151 ENOG4105DQ6 Transposase B37_00152 ENOG4105C5Y PTS System B37_00153 ENOG4105CS2 ec 3.2.1.21 B37_00154 ENOG4105CID antiterminator B37_00155 ENOG410780I phosphoprotein phosphatase activity B37_00158 ENOG4105CDY transcriptional regulatory protein B37_00161 ENOG4105C26 Dehydrogenase B37_00162 ENOG4105FKZ Methyl-accepting chemotaxis B37_00163 ENOG4105C8P )-transporter B37_00164 ENOG4105C5H ABC transporter B37_00165 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) B37_00166 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase B37_00168 ENOG4105CKI cobalamin synthesis protein B37_00169 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) B37_00170 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B37_00171 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) B37_00172 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) B37_00173 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) B37_00174 ENOG4106A3M Cytochrome p-450 B37_00176 ENOG4107SWG transcriptional regulator MERR family B37_00177 ENOG4105DXB Major Facilitator superfamily B37_00178 ENOG4105C5H ABC transporter B37_00179 ENOG4105FDU atp-dependent rna helicase B37_00180 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein B37_00182 ENOG4107QPK )-transporter B37_00189 ENOG41082BM Transcriptional regulator, arsr family B37_00190 ENOG410855V Acylphosphatase B37_00191 ENOG4108RPX mosc domain containing protein B37_00194 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) B37_00198 ENOG4105C5Y PTS System B37_00199 ENOG4105CG3 alpha amylase, catalytic region B37_00200 ENOG4107414 GntR family transcriptional regulator B37_00204 ENOG4105DQ6 Transposase B37_00206 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B37_00207 ENOG4105D7W serine acetyltransferase B37_00208 ENOG4108IAJ Nad-dependent epimerase dehydratase B37_00211 ENOG4107TVC Glycosyl transferase, family 2 B37_00214 ENOG4107QQG Dehydrogenase B37_00216 ENOG4105KVH Transcriptional regulator B37_00217 ENOG4108RCM Nitroreductase B37_00218 ENOG4105CGH 5'-nucleotidase B37_00219 ENOG4107RKG DJ-1/PfpI family B37_00221 ENOG4105BZG amino acid carrier protein B37_00222 ENOG4105KJF protein tyrosine phosphatase B37_00224 ENOG4107U9T Pfam:Ribonuclease_BN B37_00226 ENOG4108ISG Major Facilitator B37_00228 ENOG4105UPD Calcium Proton B37_00233 ENOG4105DCT glycerol dehydrogenase B37_00235 ENOG4105D7N magnesium and cobalt transport protein CorA B37_00237 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B37_00245 ENOG41079KZ Major Facilitator Superfamily B37_00249 ENOG4105EVH UPF0753 protein B37_00250 ENOG4108TWJ NADH dehydrogenase subunit 5 B37_00251 ENOG4105GPN Uncharacterized conserved protein (DUF2294) B37_00253 ENOG4107RUY (E1 component), alpha subunit B37_00255 ENOG4107QKR Dehydrogenase B37_00257 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family B37_00258 ENOG4105KK4 UPF0060 membrane protein B37_00259 ENOG4105F8D glycoside hydrolase family 4 B37_00260 ENOG4108Q3X Transcriptional regulator B37_00261 ENOG4105CI1 PTS System B37_00264 ENOG4105KVH Transcriptional regulator B37_00266 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B37_00267 ENOG4105E4I Glycoside hydrolase family 28 B37_00268 ENOG4105DSG hydrolase family 43 B37_00269 ENOG4106HBX Transcriptional Regulator AraC Family B37_00271 ENOG4105DYS nad(p)h dehydrogenase (quinone) B37_00276 ENOG4105JAB phenazine biosynthesis protein, phzf family B37_00277 ENOG4107Y03 Nitroreductase B37_00281 ENOG4105ECP epimerase B37_00282 ENOG410691R Modulates RecA activity (By similarity) B37_00287 ENOG4105CKK Glycosyl transferase, family 2 B37_00289 ENOG4105EJV Membrane B37_00290 ENOG41067AE Membrane-bound metal-dependent hydrolase B37_00291 ENOG4105CEN a g-specific adenine glycosylase B37_00292 ENOG4106BXE B37_00293 ENOG4105CAN Short-chain dehydrogenase reductase Sdr B37_00297 ENOG4105BZ1 (ABC) transporter B37_00298 ENOG4105C3U ABC transporter B37_00299 ENOG4108JQ7 (ABC) transporter B37_00300 ENOG4105DEF Extracellular solute-binding protein, family 5 B37_00301 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B37_00302 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B37_00303 ENOG4107NBY Membrane B37_00304 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase B37_00305 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B37_00306 ENOG4105G5W regulator Fur family B37_00307 ENOG4105TUA UPF0295 protein B37_00327 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B37_00358 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) B37_00364 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) B37_00365 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B37_00367 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B37_00368 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) B37_00375 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the B37_00393 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B37_00403 ENOG4108FKH Transglycosylase SLT domain B37_00407 ENOG41068G1 B37_00411 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B37_00415 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) B37_00420 ENOG410780I phosphoprotein phosphatase activity B37_00426 ENOG4107EV6 Inherit from COG: YD repeat protein B37_00430 ENOG4107EV6 Inherit from COG: YD repeat protein B37_00433 ENOG4105C22 threonyL-tRNA synthetase B37_00434 ENOG4105FF2 Type I DHQase B37_00435 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) B37_00436 ENOG4105D7T ABC transporter B37_00437 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein B37_00438 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component B37_00439 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) B37_00440 ENOG4107D63 B37_00441 ENOG4105VZ8 Transcriptional regulator B37_00443 ENOG4105DA5 (ABC) transporter B37_00447 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) B37_00450 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) B37_00452 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) B37_00456 ENOG4105CYN Serine protein kinase B37_00457 ENOG4106AKX UPF0229 protein B37_00460 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B37_00481 ENOG4107EV6 Inherit from COG: YD repeat protein B37_00485 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) B37_00491 ENOG4105K7W phage-related replication protein B37_00495 ENOG4108KU1 UPF0736 protein B37_00496 ENOG4108UK2 deaminase B37_00526 ENOG4105E4C Lytic transglycosylase catalytic B37_00533 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B37_00539 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) B37_00541 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B37_00546 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) B37_00552 ENOG4108IAB Phoh family B37_00558 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B37_00559 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B37_00565 ENOG4105CW7 secretion protein, HlyD family B37_00566 ENOG4105C0R drug resistance transporter emrb qaca subfamily B37_00567 ENOG4105CS1 NAD(P)H quinone oxidoreductase B37_00569 ENOG4105CZV ABC transporter B37_00570 ENOG4105CJ1 ABC, transporter B37_00571 ENOG4108TU7 Inherit from COG: (ABC) transporter B37_00572 ENOG4105DQ6 Transposase B37_00574 ENOG4105VEQ Cold shock protein B37_00575 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B37_00576 ENOG4108UMI ABC transporter, permease B37_00578 ENOG4107R6U sodium dicarboxylate symporter B37_00584 ENOG4105BZU Histidine kinase B37_00587 ENOG4108YBP pseudouridine synthase B37_00589 ENOG41080XP Cbs domain B37_00590 ENOG4107YBY Hydrolase B37_00591 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B37_00593 ENOG4105C5H ABC transporter B37_00594 ENOG4105TMB Formate nitrite transporter B37_00595 ENOG4105RK9 auxin efflux carrier B37_00596 ENOG4105CB2 alcohol dehydrogenase B37_00597 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B37_00599 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) B37_00600 ENOG4105C6V Glycerol-3-phosphate dehydrogenase B37_00604 ENOG4105BZU Histidine kinase B37_00605 ENOG4105WH1 Two component transcriptional regulator luxr family B37_00609 ENOG4105KPV Transcriptional regulator B37_00610 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) B37_00611 ENOG4105ED1 spovr family B37_00614 ENOG4105BZN citrate synthase B37_00616 ENOG4105CYX Short-chain dehydrogenase reductase Sdr B37_00617 ENOG4105C8J )-transporter B37_00619 ENOG41086D8 Transcriptional regulator B37_00620 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B37_00623 ENOG4105J37 B37_00624 ENOG4108AEY RNA polymerase sigma factor B37_00625 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein B37_00627 ENOG4105F6E Acyl-transferase B37_00629 ENOG4105KAF membrAne B37_00631 ENOG4105U5Y Transcriptional regulator B37_00632 ENOG4105C37 (CBS) domain B37_00635 ENOG4105C37 (CBS) domain B37_00641 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B37_00643 ENOG4105D64 Mechanosensitive ion channel B37_00644 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) B37_00647 ENOG4107VMI polysaccharide deacetylase B37_00648 ENOG4105F0I Aminotransferase B37_00650 ENOG4108N2V aldose 1-epimerase B37_00655 ENOG4105BZ1 (ABC) transporter B37_00656 ENOG4105BZ1 (ABC) transporter B37_00664 ENOG410839P B37_00666 ENOG4106MP8 UPF0754 membrane protein B37_00667 ENOG4105WZB UPF0342 protein B37_00669 ENOG4105D4P Coproporphyrinogen iii oxidase B37_00670 ENOG4107S91 Sodium hydrogen exchanger B37_00671 ENOG4105NCW Trka-c domain protein B37_00673 ENOG4105CGU Enoyl-CoA hydratase B37_00678 ENOG4108IUX (ABC) transporter B37_00679 ENOG4105RHA ABC transporter, permease B37_00680 ENOG4107VRP DNA repair exonuclease B37_00681 ENOG4106D4I domain protein B37_00682 ENOG4105EQI Metal Dependent Phosphohydrolase B37_00684 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B37_00691 ENOG4105NBU tryptophan transport protein B37_00692 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) B37_00693 ENOG4105K59 histidine triad (HIT) protein B37_00699 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation B37_00700 ENOG4105BZ4 penicillin-binding protein B37_00701 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) B37_00702 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B37_00703 ENOG4105C1Q protoporphyrinogen oxidase B37_00705 ENOG4105ECB domain protein B37_00707 ENOG4105DER m42 family B37_00710 ENOG4106AXD B37_00711 ENOG4108RQ5 Beta-lactamase domain-containing protein B37_00712 ENOG4105DF9 Lipoate-protein, ligase B37_00713 ENOG4105CEY Amp-dependent synthetase and ligase B37_00715 ENOG4108JCI Transcriptional regulator B37_00718 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 B37_00719 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B37_00720 ENOG4108UZ3 Transporter B37_00721 ENOG4108HUF Transporter B37_00722 ENOG4105DQ5 transport system permease protein B37_00723 ENOG4108U1V ABC transporter, permease B37_00724 ENOG4107TB6 phosphoglycerate mutase B37_00725 ENOG4106YBV Methyl-accepting chemotaxis B37_00729 ENOG4105XVF Competence transcription factor B37_00730 ENOG41060YP B37_00733 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin B37_00735 ENOG4105G9B Transcriptional regulator B37_00737 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) B37_00738 ENOG4105CE7 Amidase, hydantoinase carbamoylase family B37_00739 ENOG4105S0E allantoin catabolism protein B37_00740 ENOG4105DG4 malate L-lactate dehydrogenase B37_00741 ENOG4105DG4 malate L-lactate dehydrogenase B37_00742 ENOG4105DG4 malate L-lactate dehydrogenase B37_00743 ENOG4107R1Q Membrane protein FdrA B37_00744 ENOG4107REC cytoplasmic protein B37_00746 ENOG4105C5B carbamate kinase B37_00747 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) B37_00748 ENOG4107CUJ Protein of unknown function (DUF2690) B37_00749 ENOG410780I phosphoprotein phosphatase activity B37_00755 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component B37_00756 ENOG4105I1K ABC transporter B37_00758 ENOG4108KK1 membrane protein AbrB duplication B37_00761 ENOG4105WEF catalase B37_00762 ENOG4105CEY Amp-dependent synthetase and ligase B37_00763 ENOG4106K7D Major facilitator family transporter B37_00765 ENOG4105BZU Histidine kinase B37_00766 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B37_00768 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein B37_00769 ENOG4105E0C molybdate abc transporter B37_00771 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation B37_00773 ENOG4105EYH Exonuclease B37_00780 ENOG410751J B37_00784 ENOG4105ERH Fumarylacetoacetate hydrolase B37_00790 ENOG4105CAQ asparagine synthetase B37_00793 ENOG4108YZA Nitrogen regulatory protein pii B37_00794 ENOG4105UQX Mate efflux family protein B37_00795 ENOG4106HBX Transcriptional Regulator AraC Family B37_00797 ENOG4105ETE Transcriptional regulator (LacI family B37_00798 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) B37_00799 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) B37_00800 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B37_00802 ENOG4105DY8 decarboxylase B37_00807 ENOG4105MA6 gCN5-related N-acetyltransferase B37_00808 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B37_00809 ENOG4105D29 Helix-turn-helix type 11 domain protein B37_00812 ENOG4108VPT UPF0234 protein B37_00813 ENOG4105QNR S1 RNA binding domain protein B37_00816 ENOG4105EPR degv family B37_00817 ENOG4107AYK membrAne B37_00819 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) B37_00820 ENOG41073B9 B37_00821 ENOG4108KP7 hydrolase B37_00822 ENOG4108MXZ Esterase B37_00823 ENOG4105VG1 fes assembly suf system protein B37_00824 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase B37_00825 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) B37_00826 ENOG4105CAS nag kinase B37_00827 ENOG4105C8Y Acetylornithine aminotransferase B37_00828 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain B37_00830 ENOG4105DBV ornithine carbamoyltransferase B37_00831 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B37_00836 ENOG4107RMD Basic membrane lipoprotein B37_00839 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B37_00840 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) B37_00842 ENOG4105C3U ABC transporter B37_00843 ENOG4108JQ7 (ABC) transporter B37_00846 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B37_00851 ENOG4105C31 Tryptophanyl-tRNA synthetase B37_00852 ENOG4108J59 Extracellular solute-binding protein, family 5 B37_00853 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B37_00854 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B37_00856 ENOG4108JQ7 (ABC) transporter B37_00858 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) B37_00859 ENOG4108ZCF integral membrane protein B37_00860 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis B37_00864 ENOG4108V9W transcriptional regulatory protein B37_00865 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism B37_00867 ENOG4105DPN Oligoendopeptidase f B37_00869 ENOG4105T58 Dithiol-disulfide isomerase B37_00870 ENOG4108Z18 K06886 hemoglobin B37_00871 ENOG4105E4C Lytic transglycosylase catalytic B37_00872 ENOG4105MIX Adenylate cyclase B37_00873 ENOG4106EFP UPF0738 protein B37_00875 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) B37_00876 ENOG4105EMS pseudouridine synthase B37_00877 ENOG4107S1Q Phosphatase B37_00879 ENOG4105ETU transcriptional activator (TenA B37_00880 ENOG4108VEU Thiamine monophosphate synthase B37_00883 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) B37_00884 ENOG4105D06 uba thif-type nad fad binding protein B37_00885 ENOG4105DWF phosphomethylpyrimidine kinase B37_00886 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH B37_00887 ENOG4107A88 B37_00897 ENOG4105ENA helicase B37_00899 ENOG4107T5V SNARE associated Golgi B37_00900 ENOG4105CMR udp-glucose 4-epimerase B37_00901 ENOG4105CMR udp-glucose 4-epimerase B37_00902 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B37_00905 ENOG4108ZMI UPF0477 protein B37_00909 ENOG4105C28 cystathionine B37_00910 ENOG4105C28 cystathionine B37_00911 ENOG4105JHY Membrane B37_00914 ENOG4105FQP Beta-lactamase B37_00915 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase B37_00918 ENOG4108UW5 maltose o-acetyltransferase B37_00920 ENOG4105DUM transcriptional regulator, lysR family B37_00921 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B37_00922 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) B37_00924 ENOG4108Q5Y Membrane B37_00925 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase B37_00927 ENOG41069ER domain protein B37_00928 ENOG4105C0R drug resistance transporter emrb qaca subfamily B37_00929 ENOG4105J7D transcriptional regulator B37_00933 ENOG4107EV6 Inherit from COG: YD repeat protein B37_00934 ENOG4105K7W phage-related replication protein B37_00935 ENOG410635T phage-like element pbsx protein B37_00945 ENOG4108TFU terminase (Small subunit) B37_00946 ENOG4105IG6 Phage terminase, large subunit B37_00947 ENOG4108MDF Phage Portal Protein B37_00952 ENOG41060SN B37_00955 ENOG4105PQS phage protein B37_00956 ENOG4105FR7 XkdM protein, phage-like element PBSX B37_00957 ENOG4105MTC XkdN-like protein B37_00958 ENOG4108FKH Transglycosylase SLT domain B37_00959 ENOG4108WZM domain protein B37_00960 ENOG4105X7F B37_00962 ENOG4105MFU Protein of unknown function (DUF2634) B37_00963 ENOG41066EA baseplate J family protein B37_00964 ENOG410906S phage-like element pbsx protein xkdt B37_00966 ENOG41068G1 B37_00967 ENOG41068G1 B37_00970 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B37_00972 ENOG4107XBN GntR Family Transcriptional Regulator B37_00973 ENOG4105CPQ Dehydrogenase B37_00974 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) B37_00975 ENOG4105DMW Dehydrogenase reductase B37_00976 ENOG4105CPQ Dehydrogenase B37_00977 ENOG4108I5G Major Facilitator superfamily B37_00980 ENOG4105CJ3 phosphate transporter B37_00981 ENOG4107GRR phosphate transport regulator B37_00982 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) B37_00985 ENOG4105C2F Histidine kinase B37_00986 ENOG4105EQD regulatoR B37_00987 ENOG410769Z extracellular solute-binding protein family 1 B37_00988 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component B37_00989 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component B37_00990 ENOG4105F5H Glycosyl Hydrolase Family 88 B37_00991 ENOG41075H3 AraC family transcriptional regulator B37_00992 ENOG4107TDE lipolytic protein G-D-S-L family B37_00995 ENOG4105CX8 fg-gap repeat protein B37_00997 ENOG4107TDE lipolytic protein G-D-S-L family B37_00998 ENOG4105CX8 fg-gap repeat protein B37_00999 ENOG4105CPC Aldo Keto reductase B37_01000 ENOG4107TDE lipolytic protein G-D-S-L family B37_01002 ENOG4105EKC B37_01003 ENOG4105E0S extracellular solute-binding protein family 1 B37_01005 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component B37_01006 ENOG4107R7I amino acid B37_01009 ENOG4105C0H protease B37_01011 ENOG4108ME1 Peptidase M55 D-aminopeptidase B37_01012 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B37_01013 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B37_01014 ENOG4105C3U ABC transporter B37_01016 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B37_01017 ENOG4105DTQ mandelate racemase muconate lactonizing B37_01018 ENOG4107SN7 NLP P60 protein B37_01019 ENOG4108JQ7 (ABC) transporter B37_01020 ENOG4107TUM Amidinotransferase B37_01021 ENOG4108S4H thioesterase Superfamily protein B37_01023 ENOG4108J20 pectate lyase B37_01029 ENOG410839T multidrug resistance protein B37_01030 ENOG41080TC multidrug resistance protein B37_01031 ENOG4105CIY formyltetrahydrofolate deformylase B37_01032 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) B37_01033 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) B37_01036 ENOG4105K56 Transcriptional regulator B37_01037 ENOG4108ZHJ Organic hydroperoxide resistance protein B37_01039 ENOG4107Y2X deaminase B37_01040 ENOG4105CVJ phosphoglycerate mutase B37_01043 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) B37_01044 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B37_01046 ENOG4105CJW magnesium transporter B37_01048 ENOG4105V75 Transcriptional regulator B37_01053 ENOG4105DQE DNA ligase B37_01054 ENOG4105FDF Could be involved in DNA repair (By similarity) B37_01055 ENOG4105BZU Histidine kinase B37_01056 ENOG4107T5V SNARE associated Golgi B37_01057 ENOG4107TS3 membrane protein, TerC B37_01058 ENOG4108WZW RNA polymerase sigma B37_01060 ENOG410681C small acid-soluble spore protein B37_01062 ENOG4105D0M Protease HtpX homolog B37_01064 ENOG4107RVG penicillin-binding protein B37_01067 ENOG4108TGC Acyltransferase B37_01068 ENOG4105BZU Histidine kinase B37_01069 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B37_01071 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) B37_01073 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B37_01075 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate B37_01077 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) B37_01078 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) B37_01081 ENOG4105BZU Histidine kinase B37_01082 ENOG41090MY MarR family Transcriptional regulator B37_01083 ENOG4105ER2 Ompa motb domain protein B37_01084 ENOG4105E14 MotA TolQ exbB proton channel B37_01086 ENOG4108K88 Membrane B37_01087 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) B37_01088 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase B37_01089 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) B37_01090 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) B37_01095 ENOG4105NX3 Membrane B37_01096 ENOG4105VMP Transcriptional regulator B37_01101 ENOG4105DQ6 Transposase B37_01107 ENOG4105F0V Cell wall hydrolase B37_01110 ENOG4105C59 p-type ATPase B37_01111 ENOG4105DC7 peptidase M24 B37_01115 ENOG4105CID antiterminator B37_01117 ENOG4105KRI phosphocarrier protein (HPr B37_01118 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) B37_01120 ENOG4105F6S Spore photoproduct lyase B37_01122 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B37_01123 ENOG4105CHR reductase B37_01124 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B37_01125 ENOG4105K4I Scp-like extracellular B37_01127 ENOG4105BZU Histidine kinase B37_01128 ENOG4105CHM Aminotransferase B37_01132 ENOG4107R88 Chemotaxis protein (CheV) B37_01133 ENOG4105UIN B37_01135 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein B37_01137 ENOG4105K6S Short-chain dehydrogenase reductase Sdr B37_01138 ENOG4105EPM Diguanylate phosphodiesterase B37_01140 ENOG4107IN1 Protein of unknown function (DUF1797) B37_01142 ENOG4108XRC Protein of unknown function (DUF458) B37_01148 ENOG4105NQC Flavodoxin B37_01149 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) B37_01152 ENOG4105D3R alkyl hydroperoxide reductase B37_01153 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B37_01156 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) B37_01157 ENOG4105D06 uba thif-type nad fad binding protein B37_01158 ENOG4105CVM Molybdenum cofactor synthesis domain protein B37_01159 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein B37_01160 ENOG4108ZAF Molybdopterin B37_01161 ENOG41067WU Molybdopterin converting factor (Subunit 1) B37_01163 ENOG4105BZ1 (ABC) transporter B37_01164 ENOG4105BZ1 (ABC) transporter B37_01166 ENOG4107X8C Efflux transporter RND family MFP subunit B37_01167 ENOG4105C19 ABC transporter B37_01168 ENOG4107RBB ABC transporter, permease B37_01169 ENOG4105E98 transcriptional regulator DeoR family B37_01170 ENOG4105DE4 1-phosphofructokinase B37_01171 ENOG4105DM4 PTS System B37_01172 ENOG4105C3F Signal peptidase i B37_01175 ENOG4105C5H ABC transporter B37_01181 ENOG4105BZU Histidine kinase B37_01182 ENOG4107ZYR domain protein B37_01184 ENOG4105CN5 Metallo-Beta-Lactamase B37_01186 ENOG4108X4Q Hydrolase B37_01188 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B37_01192 ENOG4105CPP Dehydrogenase, E1 component B37_01193 ENOG4105C7S Dehydrogenase B37_01194 ENOG4107QN2 dihydrolipoyl dehydrogenase B37_01198 ENOG4105CXN decarboxylase B37_01199 ENOG4105WBI UPF0223 protein B37_01202 ENOG4105ECY inositol monophosphatase B37_01209 ENOG4105CI3 gtp-binding protein typa B37_01210 ENOG4105QA2 B37_01211 ENOG4108INS Transcriptional regulator B37_01212 ENOG4107SCK Monooxygenase B37_01215 ENOG4108IAB Phoh family B37_01217 ENOG4105CSV Glutaminase B37_01218 ENOG4105ZPI UPF0358 protein B37_01219 ENOG4105CNI cell division protein FtsW B37_01220 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) B37_01222 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) B37_01224 ENOG4105BZ9 Cytochrome C oxidase, subunit I B37_01225 ENOG4105CCU oxidase (Subunit III) B37_01226 ENOG41064X9 cytochrome C oxidase subunit IV B37_01229 ENOG41080XQ Signal transduction protein with cbs domains B37_01230 ENOG4106UY4 Inherit from COG: Scp-like extracellular B37_01237 ENOG4106H78 methyltransferase B37_01238 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) B37_01239 ENOG4105H20 Sporulation integral membrane protein YlbJ B37_01240 ENOG41063PX domain protein B37_01241 ENOG4105CDE UPF0348 protein B37_01242 ENOG4105KNH Nucleic acid-binding protein B37_01243 ENOG41067VY 50S ribosomal protein L32 B37_01247 ENOG41074B2 UPF0747 protein B37_01248 ENOG4108V6E Cell division protein mraZ B37_01249 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) B37_01251 ENOG4105CJN penicillin-binding protein B37_01252 ENOG4105CJN penicillin-binding protein B37_01254 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) B37_01255 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) B37_01256 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) B37_01257 ENOG4105CNI cell division protein FtsW B37_01258 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B37_01259 ENOG4105D4A Cell wall formation (By similarity) B37_01260 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) B37_01261 ENOG4108R2U division initiation protein B37_01263 ENOG4105K67 small basic protein B37_01264 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) B37_01265 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) B37_01270 ENOG4105FFI sigma-e processing peptidase spoiiga B37_01271 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B37_01273 ENOG4105DKW ABC transporter B37_01274 ENOG4105DHI Methyltransferase B37_01275 ENOG4105WR5 sporulation protein, YlmC YmxH family B37_01276 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase B37_01277 ENOG4105DFA alanine racemase domain protein B37_01278 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) B37_01279 ENOG41067XK integral membrane protein B37_01280 ENOG4105DBK s4 domain protein B37_01284 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) B37_01285 ENOG4105C34 Pseudouridine synthase B37_01286 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) B37_01288 ENOG4105CXT aspartate transcarbamylase B37_01289 ENOG4105CD3 dihydroorotase B37_01290 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain B37_01291 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain B37_01292 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) B37_01293 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) B37_01294 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) B37_01297 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) B37_01301 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B37_01302 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B37_01303 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B37_01304 ENOG4105F23 Fibronectin-binding protein B37_01306 ENOG4105DSJ YicC domain protein B37_01307 ENOG4105KC4 UPF0296 protein B37_01308 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) B37_01309 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) B37_01310 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase B37_01311 ENOG4105C25 Primosomal protein n' B37_01312 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B37_01313 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) B37_01314 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B B37_01315 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs B37_01316 ENOG4108ZF3 Phosphatase B37_01317 ENOG4105D9P serine threonine protein kinase B37_01318 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) B37_01319 ENOG4105DJV ribulose-phosphate 3-epimerase B37_01320 ENOG4105FJ0 thiamine B37_01321 ENOG4105VB9 50S ribosomal protein l28 B37_01322 ENOG4108ZAA Alkaline-shock protein B37_01323 ENOG4105DP4 dak2 domain fusion protein ylov B37_01325 ENOG4105EJQ L-serine dehydratase B37_01326 ENOG4105CB5 ATP-dependent DNA helicase recG B37_01327 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) B37_01328 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) B37_01329 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase B37_01330 ENOG4105CHR reductase B37_01331 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) B37_01332 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) B37_01333 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) B37_01334 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) B37_01335 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) B37_01337 ENOG4105K5M 30s ribosomal protein S16 B37_01338 ENOG4108BW8 UPF0109 protein B37_01340 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) B37_01341 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) B37_01342 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) B37_01343 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) B37_01344 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B37_01346 ENOG4105VM1 flagellar B37_01347 ENOG4105CMV Succinyl-CoA synthetase subunit beta B37_01348 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha B37_01349 ENOG4105C79 DNA protecting protein DprA B37_01350 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) B37_01351 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) B37_01352 ENOG4108HE4 integrase family B37_01353 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) B37_01354 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) B37_01355 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) B37_01357 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) B37_01358 ENOG4108ZC9 flagellar basal-body rod protein flgc B37_01359 ENOG4105VQ0 flagellar hook-basal body complex protein fliE B37_01360 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) B37_01361 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B37_01364 ENOG4106YF4 Flagellar biosynthesis chaperone B37_01366 ENOG410696Y Flagellar hook-length control protein B37_01367 ENOG410822I Flagellar hook capping protein B37_01368 ENOG4108JQA flagellar B37_01370 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B37_01371 ENOG4105DD5 Flagellar motor switch protein B37_01372 ENOG4107YTP response regulator receiver protein B37_01374 ENOG4105CN7 Flagellar biosynthetic protein FliP B37_01375 ENOG4105VS8 Flagellar biosynthetic protein fliq B37_01376 ENOG4105D19 Role in flagellar biosynthesis (By similarity) B37_01377 ENOG4105D00 flagellar biosynthetic protein flhB B37_01378 ENOG4105D7B Flagellar biosynthesis protein flha B37_01379 ENOG4105FZW flagellar biosynthesis regulator FlhF B37_01381 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) B37_01382 ENOG4105CBS Chea signal transduction histidine kinase B37_01383 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis B37_01385 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) B37_01386 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B37_01388 ENOG4105CE9 30S ribosomal protein S2 B37_01389 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) B37_01391 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) B37_01392 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) B37_01393 ENOG4105KNE Phosphatidate cytidylyltransferase B37_01395 ENOG4105DZP Membrane-associated zinc metalloprotease B37_01397 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B37_01400 ENOG4105CYP glycoside hydrolase, family B37_01403 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) B37_01404 ENOG4105CHV Transcription elongation factor NusA B37_01405 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination B37_01406 ENOG4105VHM ribosomal protein B37_01407 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) B37_01408 ENOG4105W7A Protein of unknown function (DUF503) B37_01409 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) B37_01410 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) B37_01411 ENOG4105DTN riboflavin biosynthesis protein ribF B37_01412 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) B37_01413 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) B37_01415 ENOG4105C1V Peptidase, M16 B37_01417 ENOG4105E35 Dipicolinate synthase subunit A B37_01418 ENOG4108S0H Dipicolinic acid synthetase, b subunit B37_01419 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B37_01421 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B37_01423 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit B37_01425 ENOG4105CNU cell division protein FtsK B37_01426 ENOG4105FDP GntR family transcriptional regulator B37_01430 ENOG4108RKS Short-chain dehydrogenase reductase Sdr B37_01431 ENOG4105XZV Protein of unknown function (DUF3243) B37_01434 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase B37_01435 ENOG4105CEV competence damage-inducible protein B37_01436 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) B37_01438 ENOG4105D48 metallophosphoesterase B37_01439 ENOG4105MCT stage V sporulation protein S B37_01440 ENOG4108IGT Dipeptidase B37_01441 ENOG4105CPQ Dehydrogenase B37_01442 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) B37_01443 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B37_01446 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) B37_01447 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) B37_01449 ENOG4107EV6 Inherit from COG: YD repeat protein B37_01452 ENOG4105CKI cobalamin synthesis protein B37_01454 ENOG4107TCE N-acetyltransferase B37_01458 ENOG4105XPP Protein of unknown function (DUF1275) B37_01459 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) B37_01460 ENOG4108J8C transporter major facilitator family protein B37_01461 ENOG4108J8C transporter major facilitator family protein B37_01462 ENOG4105U6C Alpha beta hydrolase fold protein B37_01464 ENOG41080BT SNARE associated Golgi B37_01465 ENOG4105FQP Beta-lactamase B37_01466 ENOG41087PP glycosyltransferase MGT family B37_01467 ENOG4107QTZ amino acid B37_01470 ENOG4105VRS hydrolase family 18 B37_01471 ENOG4105M4P Tetr family transcriptional regulator B37_01472 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein B37_01473 ENOG4107S9F NmrA family B37_01475 ENOG4108X3M OsmC Ohr family protein B37_01476 ENOG4107E54 Small Multidrug Resistance protein B37_01480 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) B37_01481 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) B37_01483 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) B37_01484 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B37_01485 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B37_01486 ENOG4105U6W MutT NUDIX family protein B37_01489 ENOG4108UNV SUF system FeS assembly protein, NifU family B37_01490 ENOG4105G5W regulator Fur family B37_01491 ENOG4105DRR Transcriptional regulator, GntR family B37_01498 ENOG4105PF9 Transcriptional regulator B37_01507 ENOG4107EV6 Inherit from COG: YD repeat protein B37_01511 ENOG4106F1P AAA ATPase, central domain protein B37_01512 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B37_01513 ENOG4105CXI aluminum resistance protein B37_01514 ENOG4105KV4 Transcriptional regulator B37_01515 ENOG4105C5F glutamine synthetase B37_01536 ENOG4108MK9 spermidine N(1)-acetyltransferase B37_01539 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B37_01544 ENOG41062JF Transcriptional regulator B37_01545 ENOG41090MY MarR family Transcriptional regulator B37_01546 ENOG4108TVJ Nitroreductase B37_01547 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase B37_01548 ENOG4107XWI flavin reductase domain protein, FMN-binding B37_01549 ENOG4105CS1 NAD(P)H quinone oxidoreductase B37_01552 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) B37_01553 ENOG4105WFK nuclease B37_01554 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B37_01556 ENOG4108SVB resolvase B37_01557 ENOG4105VPS UPF0291 protein B37_01558 ENOG4105CV1 Transketolase (EC 2.2.1.1) B37_01560 ENOG4105VXM UPF0154 protein B37_01562 ENOG4107QIV Cytochrome c biogenesis protein B37_01567 ENOG4108I0Z Aconitate hydratase B37_01568 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B37_01573 ENOG4105MI2 B37_01576 ENOG4105W8X HesB YadR YfhF-family protein B37_01577 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) B37_01578 ENOG4105K4P CoA-binding domain protein B37_01579 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B37_01581 ENOG4105CMD Transcriptional regulator, GntR family B37_01584 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) B37_01585 ENOG4107QNK )-transporter B37_01586 ENOG4105CHR reductase B37_01592 ENOG4105R3A Nitrate reductase B37_01593 ENOG4108IUE nitrate reductase beta subunit B37_01600 ENOG4107V6Q Cyclic nucleotide-binding domain B37_01603 ENOG4105IJJ transcriptional regulator, crp fnr family B37_01604 ENOG4105DSQ Nitric oxide reductase B37_01605 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) B37_01606 ENOG4106U2H Protein of unknown function (DUF1360) B37_01607 ENOG4107QWR cellulase (EC 3.2.1.4) B37_01609 ENOG4108428 Inherit from COG: -acetyltransferase B37_01611 ENOG4105C3M thioredoxin reductase B37_01614 ENOG4108M26 parallel beta-helix repeat protein B37_01616 ENOG4105DQ4 alcohol dehydrogenase B37_01617 ENOG4105VUF Transcriptional regulator B37_01622 ENOG41060WC Enoyl-CoA hydratase B37_01623 ENOG4105C26 Dehydrogenase B37_01624 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B37_01625 ENOG4105C1G acyl-Coa dehydrogenase B37_01626 ENOG4105DG6 mannose-6-phosphate isomerase B37_01627 ENOG4105DM4 PTS System B37_01634 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B37_01635 ENOG4105DMW Dehydrogenase reductase B37_01636 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) B37_01638 ENOG4105CG6 trap dicarboxylate transporter dctm subunit B37_01639 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter B37_01640 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit B37_01641 ENOG4107KJX Transcriptional regulator B37_01642 ENOG4108UXE Protein tyrosine phosphatase B37_01643 ENOG4107R5R arsenical pump membrane protein B37_01644 ENOG41082YX Transcriptional regulator, arsr family B37_01645 ENOG4105CZ9 Domain of unknown function (DU1801) B37_01647 ENOG4105CSC Glucose uptake protein B37_01648 ENOG4105F32 YngK protein B37_01651 ENOG4105F1A Pyruvate formate-lyase B37_01653 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family B37_01654 ENOG4105H67 Protein of unknown function (DUF421) B37_01655 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B37_01657 ENOG4108QY0 Membrane B37_01660 ENOG4105CZ3 stage V sporulation protein ad B37_01661 ENOG41090VF Stage v sporulation protein ac B37_01663 ENOG4105DQ6 Transposase B37_01664 ENOG4105WEF catalase B37_01668 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B37_01677 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B37_01678 ENOG4107QX3 carboxylase B37_01679 ENOG4105E39 Enoyl-CoA hydratase B37_01680 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase B37_01681 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit B37_01682 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B37_01683 ENOG4105CEY Amp-dependent synthetase and ligase B37_01684 ENOG4105C1G acyl-Coa dehydrogenase B37_01685 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B37_01686 ENOG4105KVH Transcriptional regulator B37_01687 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) B37_01688 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) B37_01691 ENOG4105H67 Protein of unknown function (DUF421) B37_01693 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) B37_01694 ENOG41061P3 phosphosulfolactate synthase B37_01696 ENOG4105DIA mandelate racemase muconate lactonizing B37_01697 ENOG4107RCC Major Facilitator Superfamily B37_01701 ENOG4105BZ8 glutamate synthase B37_01702 ENOG4105CBC glutamate synthase B37_01703 ENOG4105C5Q Transcriptional regulator B37_01709 ENOG4105BZ1 (ABC) transporter B37_01712 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B37_01713 ENOG4105C0R drug resistance transporter emrb qaca subfamily B37_01714 ENOG4108J2R molybdopterin oxidoreductase B37_01717 ENOG4108Q8B Spore germination protein B37_01718 ENOG4108NHD germination protein B37_01719 ENOG4108Q8B Spore germination protein B37_01720 ENOG4108Q8B Spore germination protein B37_01723 ENOG4105C8Q Methyl-accepting chemotaxis B37_01724 ENOG4108Z7R Chaperone CsaA B37_01725 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B37_01727 ENOG4108RZE Tetr family transcriptional regulator B37_01729 ENOG4105T9C HD domain B37_01731 ENOG4105FVX B37_01735 ENOG4108W8B Beta-lactamase domain protein B37_01738 ENOG4105D29 Helix-turn-helix type 11 domain protein B37_01740 ENOG4105KTU Transcriptional regulator, arsr family B37_01743 ENOG4105CUB amino acid B37_01745 ENOG4105C5E polysaccharide biosynthesis protein B37_01748 ENOG4107T8Q Glycosyl transferase (Group 1 B37_01749 ENOG4108SJC Membrane B37_01752 ENOG4107RUZ Sss sodium solute transporter superfamily B37_01753 ENOG41069ER domain protein B37_01754 ENOG4105C9U ATP-dependent DNA helicase RecQ B37_01759 ENOG4105UNS Pfam:DUF419 B37_01762 ENOG4108IEG Formate dehydrogenase Alpha subunit B37_01764 ENOG4107EV6 Inherit from COG: YD repeat protein B37_01773 ENOG4108NHD germination protein B37_01776 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) B37_01779 ENOG4107S9D Alpha beta hydrolase B37_01783 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) B37_01785 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B37_01786 ENOG4105ST3 Transcriptional regulator B37_01790 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) B37_01791 ENOG4105SCY DNAK suppressor B37_01794 ENOG4105C26 Dehydrogenase B37_01798 ENOG4105EWU Squalene--hopene cyclase B37_01799 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B37_01801 ENOG4105C8J )-transporter B37_01802 ENOG4105C09 Bile acid B37_01803 ENOG4105C7S Dehydrogenase B37_01804 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 B37_01805 ENOG4107T89 von Willebrand factor, type A B37_01806 ENOG4105GMT ATPase associated with various cellular activities aaa_5 B37_01808 ENOG4105K4H Nlp p60 protein B37_01813 ENOG4105FR1 rard protein B37_01816 ENOG4108YQE rare lipoprotein a B37_01818 ENOG4107EXU Short-chain dehydrogenase reductase Sdr B37_01821 ENOG4105FBA Phospholipase Carboxylesterase B37_01823 ENOG4105E1V na solute symporter B37_01824 ENOG4105DQ6 Transposase B37_01829 ENOG4108VXD carboxy-peptidase B37_01830 ENOG4105D3A purine nucleoside phosphorylase DeoD-type B37_01831 ENOG4108PJD permease B37_01834 ENOG4106Z5R B37_01835 ENOG410841Q phosphoesterase PA-phosphatase related protein B37_01839 ENOG4105VSD UPF0346 protein B37_01841 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein B37_01842 ENOG4108TSC N-acetyltransferase B37_01843 ENOG4107S4Y M20 DapE family protein YgeY B37_01846 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B37_01849 ENOG4105E0X reductase B37_01853 ENOG4105BZU Histidine kinase B37_01857 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) B37_01858 ENOG41090WU lipolytic protein G-D-S-L family B37_01859 ENOG4108KF3 Electron transport protein SCO1 SenC B37_01862 ENOG4105C7B Threonine dehydratase B37_01864 ENOG4108UT2 hemolysin iii B37_01866 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) B37_01869 ENOG4107YX5 Pfam:DUF548 B37_01871 ENOG4105C01 Dihydroxy-acid dehydratase B37_01874 ENOG4108V06 Glutathione peroxidase B37_01875 ENOG4105CKU formyltetrahydrofolate synthetase B37_01876 ENOG4105CVG Homoserine O-transsuccinylase B37_01877 ENOG4108QBV Monogalactosyldiacylglycerol synthase B37_01885 ENOG41081VK Ribonuclease B37_01890 ENOG410890F Dynamin family B37_01891 ENOG410890F Dynamin family B37_01893 ENOG41065KQ synthase B37_01894 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B37_01895 ENOG4105C2W permease B37_01896 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) B37_01897 ENOG4105CTD carboxy-peptidase B37_01898 ENOG4105DVT helicase B37_01901 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) B37_01902 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) B37_01903 ENOG4108UKS UPF0398 protein B37_01906 ENOG4107X2U Inherit from COG: Exonuclease-like protein B37_01907 ENOG4108I5C dEAD DEAH box helicase B37_01917 ENOG4105BZ4 penicillin-binding protein B37_01919 ENOG4105CSM endonuclease III B37_01922 ENOG4105CHM Aminotransferase B37_01924 ENOG4105YAC B37_01925 ENOG4105DVT helicase B37_01926 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) B37_01927 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) B37_01928 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) B37_01930 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate B37_01931 ENOG4105CPK Glycosyl transferase (Group 1 B37_01932 ENOG4105FJR Lmbe family B37_01933 ENOG4108Z5K methylglyoxal synthase B37_01934 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) B37_01935 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase B37_01936 ENOG4108JYZ YitT family B37_01940 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) B37_01943 ENOG4108SXZ UPF0302 protein B37_01944 ENOG41068YB TPR repeat-containing protein B37_01947 ENOG4105CIH Imidazole acetol-phosphate transaminase B37_01948 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) B37_01949 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) B37_01951 ENOG4105DK0 Indole-3-glycerol phosphate synthase B37_01952 ENOG4108I0Q anthranilate phosphoribosyltransferase B37_01953 ENOG4105CRQ synthase (Component I) B37_01954 ENOG4105KHN chorismate mutase B37_01955 ENOG4105D49 3-dehydroquinate synthase B37_01956 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase B37_01957 ENOG4105BZU Histidine kinase B37_01958 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) B37_01959 ENOG4105EAH synthase B37_01960 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B37_01961 ENOG4105XXQ heptaprenyl diphosphate synthase component I B37_01963 ENOG4105EUJ GTP cyclohydrolase i B37_01964 ENOG4105K70 DNA-binding protein B37_01965 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) B37_01969 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase B37_01970 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) B37_01971 ENOG41065D1 B37_01972 ENOG4105S2F B37_01975 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) B37_01976 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) B37_01977 ENOG4105CAT Cytidine monophosphate kinase B37_01979 ENOG4105MSI germination protein ypeb B37_01982 ENOG4105HDK L-asparaginase B37_01983 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase B37_01986 ENOG4107RGJ metallophosphoesterase B37_01989 ENOG4105I7S Abortive infection protein B37_01990 ENOG4105C9U ATP-dependent DNA helicase RecQ B37_01991 ENOG4105T7X B37_01993 ENOG4108SAX Membrane B37_01994 ENOG4108JQ1 Dehydrogenase B37_01995 ENOG4105DR5 peptidase B37_02001 ENOG4105US7 Histidine kinase B37_02002 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B37_02003 ENOG4105BZU Histidine kinase B37_02004 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B37_02005 ENOG4105CRE cytochrome C B37_02006 ENOG4107TWT Cytochrome c biogenesis protein B37_02007 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B37_02008 ENOG4105FE9 pseudouridine synthase B37_02010 ENOG4108JIC nucleoside recognition domain protein B37_02011 ENOG4105DZ1 carboxypeptidase B37_02013 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) B37_02014 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) B37_02018 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) B37_02019 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) B37_02020 ENOG4108R6K riboflavin synthase, subunit alpha B37_02021 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) B37_02023 ENOG4105MEW serine threonine protein phosphatase B37_02024 ENOG4105MYT Heat shock protein B37_02027 ENOG4107ZE5 PPIases accelerate the folding of proteins B37_02028 ENOG4105PTM secreted protein B37_02029 ENOG4105K7W phage-related replication protein B37_02030 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) B37_02033 ENOG4105G6R Stage v sporulation protein ae B37_02035 ENOG4105CZ3 stage V sporulation protein ad B37_02036 ENOG41090VF Stage v sporulation protein ac B37_02039 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B37_02040 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) B37_02041 ENOG41082AN stage II sporulation protein B37_02042 ENOG4105DZ1 carboxypeptidase B37_02043 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) B37_02044 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) B37_02045 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B37_02047 ENOG4105I3K Ferric uptake regulator, Fur family B37_02048 ENOG4105MZ9 stage II sporulation protein m B37_02049 ENOG4105CK1 PTS System B37_02051 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease B37_02052 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease B37_02055 ENOG4107YB6 acetyltransferase, (GNAT) family B37_02057 ENOG4108YZ4 nudix hydrolase B37_02059 ENOG4105PF9 Transcriptional regulator B37_02061 ENOG4105CPC Aldo Keto reductase B37_02065 ENOG4106HZJ B37_02067 ENOG4105RHY Pfam:UPF0157 B37_02068 ENOG4105KAC Antibiotic biosynthesis monooxygenase B37_02069 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold B37_02071 ENOG4107RRN ABC transporter substrate-binding protein B37_02072 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B37_02073 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B37_02074 ENOG4108RZA ABC transporter B37_02075 ENOG4107R73 Mate efflux family protein B37_02079 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B37_02081 ENOG4105E5W Transporter B37_02082 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase B37_02085 ENOG4105DA5 (ABC) transporter B37_02089 ENOG4105K7W phage-related replication protein B37_02090 ENOG4108IXY short-chain dehydrogenase reductase B37_02091 ENOG41069FQ Metallo-beta-lactamase superfamily B37_02092 ENOG4105II7 pyrroline-5-carboxylate reductase B37_02094 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B37_02097 ENOG4105WDJ 50S ribosomal protein L33 B37_02098 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) B37_02099 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase B37_02103 ENOG4108TZY GntR Family Transcriptional Regulator B37_02104 ENOG4105CS2 ec 3.2.1.21 B37_02105 ENOG4105CK1 PTS System B37_02106 ENOG4105VCP PTS System B37_02107 ENOG4105VZJ PTS System B37_02108 ENOG4105G6Z alkaline phosphatase B37_02109 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B37_02110 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) B37_02111 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B37_02113 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) B37_02114 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B37_02115 ENOG4108HNZ carboxyl transferase B37_02116 ENOG4108QEG Membrane B37_02117 ENOG4105CDA abc transporter atp-binding protein B37_02118 ENOG4105E5Q amino acid AbC transporter B37_02119 ENOG4108HW3 (ABC) transporter B37_02121 ENOG4108Y6J UPF0403 protein B37_02122 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) B37_02123 ENOG4105C7S Dehydrogenase B37_02124 ENOG4105CPP Dehydrogenase, E1 component B37_02127 ENOG4105CKM Branched-chain carboxylic acid kinase B37_02128 ENOG4107RDP Dehydrogenase B37_02130 ENOG4108JUB Transcriptional regulator B37_02131 ENOG4106CCJ Protein of unknown function (DUF2627) B37_02132 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B37_02133 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B37_02135 ENOG4105D7W serine acetyltransferase B37_02137 ENOG4107QQR Sporulation B37_02138 ENOG4105S1Z Stage IV sporulation protein B B37_02139 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) B37_02140 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) B37_02141 ENOG4105DX0 Hemolysin A B37_02142 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) B37_02143 ENOG4105CTB Polyprenyl synthetase B37_02144 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B37_02145 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B37_02146 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) B37_02147 ENOG4105M7K Involved in the transcription termination process (By similarity) B37_02148 ENOG4108ZSR alkaline shock protein B37_02149 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B37_02153 ENOG410644B Stage III sporulation protein af B37_02155 ENOG4105KQ4 Stage iii sporulation protein ad B37_02156 ENOG4108CQH stage III sporulation protein AC B37_02157 ENOG4105KR5 Stage iii sporulation protein B37_02158 ENOG4105CD2 stage iii sporulation protein aa B37_02160 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) B37_02161 ENOG4105DC7 peptidase M24 B37_02162 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) B37_02164 ENOG4105CBJ Metal-dependent enzyme B37_02167 ENOG4105KST dependent repressor B37_02168 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) B37_02169 ENOG4105WZW rhodanese family B37_02171 ENOG4107SQ8 Glycine betaine B37_02172 ENOG4108IJ7 Glycine betaine B37_02173 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor B37_02175 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) B37_02176 ENOG4105C0D helicase B37_02181 ENOG4105VFR signal peptidase B37_02188 ENOG4106855 Competence protein B37_02195 ENOG4105C5X domain protein B37_02202 ENOG4105E0M Sulfatase B37_02206 ENOG4107ZXI Rhomboid family B37_02208 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase B37_02209 ENOG4105WDJ 50S ribosomal protein L33 B37_02213 ENOG41068DG YceG-like family B37_02214 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B37_02215 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B37_02216 ENOG4105E2Z phosphate ABC transporter (Permease B37_02217 ENOG4105C8U phosphate abc transporter B37_02218 ENOG4105CVA phosphate B37_02219 ENOG4107RF6 penicillin-binding protein B37_02221 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B37_02222 ENOG4105SXS Protein of unknown function (DUF456) B37_02225 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) B37_02226 ENOG41063Y9 B37_02227 ENOG4108U5J '-nucleotidase B37_02228 ENOG4105N80 Ferric uptake regulator, Fur family B37_02229 ENOG4105FAV ABC, transporter B37_02230 ENOG4105FDK ABC transporter B37_02231 ENOG4108JYZ YitT family B37_02232 ENOG41069ZM Protein of unknown function (DUF2624) B37_02233 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) B37_02236 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) B37_02237 ENOG4105EGD dinuclear metal center protein, YbgI family B37_02239 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) B37_02240 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) B37_02253 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B37_02254 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) B37_02256 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) B37_02258 ENOG4105C38 Glycyl-tRNA synthetase beta subunit B37_02259 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit B37_02260 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) B37_02262 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) B37_02263 ENOG4105KG3 cytidine deaminase B37_02264 ENOG4107YR5 Diacylglycerol kinase B37_02265 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) B37_02266 ENOG4105CTJ Metal Dependent Phosphohydrolase B37_02267 ENOG4105C9A Phoh family B37_02268 ENOG4105EI1 sporulation protein yqfd B37_02269 ENOG41068P3 sporulation protein YqfC B37_02271 ENOG4105DI5 UPF0365 protein B37_02272 ENOG4105F7J membrane-bound serine protease B37_02273 ENOG4105KTH gatB Yqey B37_02274 ENOG4105VCC 30S ribosomal protein S21 B37_02276 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) B37_02277 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B37_02278 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) B37_02279 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) B37_02280 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) B37_02281 ENOG4105CFG Acts as a chaperone (By similarity) B37_02282 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ B37_02283 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) B37_02284 ENOG4105CSA Coproporphyrinogen iii oxidase B37_02285 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) B37_02287 ENOG4108ZRV stage ii sporulation protein p B37_02290 ENOG4105TQK DNA polymerase iii, delta' subunit B37_02292 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 B37_02293 ENOG4108UK2 deaminase B37_02294 ENOG4105KQC Competence protein B37_02296 ENOG4108D32 Methyltransferase B37_02298 ENOG4108WF2 Metal Dependent Phosphohydrolase B37_02299 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) B37_02300 ENOG410812S Rna-binding protein B37_02301 ENOG4105E2X shikimate dehydrogenase B37_02302 ENOG4105CQW ribosome biogenesis GTPase YqeH B37_02303 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase B37_02306 ENOG4105Z7P Acetyltransferase (GNAT) family B37_02307 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) B37_02308 ENOG4108JB9 formate dehydrogenase B37_02311 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B37_02316 ENOG4108ZRV stage ii sporulation protein p B37_02318 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B37_02322 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B37_02324 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) B37_02325 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) B37_02327 ENOG4105EFI regulatoR B37_02328 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B37_02337 ENOG4105WH1 Two component transcriptional regulator luxr family B37_02338 ENOG4105BZU Histidine kinase B37_02339 ENOG4105XXY Thioredoxin B37_02340 ENOG41087NI Sulfite exporter TauE/SafE B37_02341 ENOG4105VFE sira family B37_02342 ENOG4107TPS domain protein B37_02343 ENOG4105VFE sira family B37_02344 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase B37_02345 ENOG4105XTG Pfam:DUF156 B37_02346 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) B37_02349 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) B37_02351 ENOG41080HJ 6-phospho 3-hexuloisomerase B37_02352 ENOG4108VA3 3-hexulose-6-phosphate synthase B37_02353 ENOG4105KVH Transcriptional regulator B37_02354 ENOG4105ECK Fatty Acid Desaturase B37_02355 ENOG4108ZGX Histidine kinase B37_02356 ENOG4108S01 response regulator B37_02357 ENOG4105CAY ferredoxin--nadp reductase B37_02358 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein B37_02359 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B37_02360 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B37_02362 ENOG4108JQ7 (ABC) transporter B37_02365 ENOG4108ZX5 transcriptional regulator B37_02366 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B37_02370 ENOG410635A Membrane B37_02372 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B37_02373 ENOG4108HKT sucrose-6-phosphate hydrolase B37_02374 ENOG4105F3R pts system mannose fructose sorbose family iid B37_02375 ENOG4105ETZ PTS System B37_02376 ENOG4108IQ3 PTS system B37_02377 ENOG4105YHU PTS system B37_02378 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family B37_02379 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family B37_02381 ENOG4105WDR B37_02384 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B37_02385 ENOG4105CV8 reductase B37_02386 ENOG4105F27 Major Facilitator B37_02387 ENOG4105KVH Transcriptional regulator B37_02388 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) B37_02389 ENOG4105EXQ uroporphyrinogen iii synthase hem4 B37_02391 ENOG4108V5C ABC transporter B37_02392 ENOG4107RSM transcriptional regulator B37_02393 ENOG4105D94 Major Facilitator Superfamily B37_02395 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B37_02396 ENOG41082JN Transcriptional regulator B37_02397 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B37_02402 ENOG4105C28 cystathionine B37_02404 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B37_02405 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) B37_02408 ENOG4107XRG penicillin-binding protein B37_02409 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) B37_02411 ENOG4105CFP Peptidase U32 B37_02412 ENOG4105XYU peptidase (U32 family) B37_02413 ENOG4108VQJ O-methyltransferase B37_02414 ENOG4105HHA aminodeoxychorismate lyase B37_02415 ENOG4105VPH UPF0473 protein B37_02416 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) B37_02417 ENOG4105VBH UPF0297 protein B37_02418 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B37_02419 ENOG4105C02 permease B37_02420 ENOG41060CR B37_02422 ENOG4105C7H Helicase, RecD TraA family B37_02424 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) B37_02425 ENOG4105C3J Cysteine desulfurase B37_02427 ENOG4105D1H recombination factor protein RarA B37_02428 ENOG4105CUZ uba thif-type nad fad binding protein B37_02429 ENOG4105C9M aspartyl-trna synthetase B37_02430 ENOG4105CUT histidyl-tRNA synthetase B37_02432 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B37_02433 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) B37_02434 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B37_02435 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) B37_02436 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) B37_02437 ENOG41067VP Protein of unknown function (DUF1049) B37_02438 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) B37_02440 ENOG4105CKP Polysaccharide Biosynthesis Protein B37_02441 ENOG4108QG2 Membrane B37_02442 ENOG4105NAP B37_02443 ENOG4105VIE preprotein translocase, subunit YajC B37_02444 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) B37_02445 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) B37_02446 ENOG41061AI Protein of unknown function (DUF2905) B37_02447 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) B37_02448 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) B37_02452 ENOG41069DP small acid-soluble spore protein B37_02454 ENOG4105K7W phage-related replication protein B37_02457 ENOG4105CDY transcriptional regulatory protein B37_02460 ENOG4106678 morphogenetic protein associated with SpoVID B37_02461 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) B37_02462 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase B37_02463 ENOG4108IYU L-aspartate oxidase B37_02466 ENOG4105CQC Prephenate dehydratase B37_02467 ENOG41090I5 UPF0735 ACT domain-containing protein B37_02468 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control B37_02470 ENOG4105K46 50S ribosomal protein l27 B37_02471 ENOG4105X36 (ribosomal) protein B37_02472 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) B37_02476 ENOG41082BM Transcriptional regulator, arsr family B37_02477 ENOG4107QMS site-determining protein B37_02478 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) B37_02479 ENOG4105YHC Rod shape-determining protein MreD B37_02480 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) B37_02481 ENOG4105DFF Rod shape-determining protein mreb B37_02482 ENOG4105W5Q DNA repair protein (RadC B37_02494 ENOG41068G1 B37_02496 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj B37_02510 ENOG4105CAR Terminase, large subunit B37_02536 ENOG4108C33 Resolvase B37_02537 ENOG4105W5Q DNA repair protein (RadC B37_02538 ENOG4108Z03 MAF-like protein B37_02540 ENOG4106A3R peptidase B37_02541 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase B37_02542 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) B37_02544 ENOG4106AR7 Spore coat protein B37_02545 ENOG41068KH stage VI sporulation protein D B37_02546 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase B37_02547 ENOG4105D52 delta-aminolevulinic acid dehydratase B37_02549 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) B37_02551 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) B37_02553 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) B37_02554 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) B37_02555 ENOG4108IUQ atp-dependent protease B37_02556 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) B37_02557 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation B37_02559 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) B37_02560 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) B37_02561 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) B37_02562 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) B37_02563 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B37_02564 ENOG4108ZP8 Acetolactate synthase small subunit B37_02565 ENOG4105C7K acetolactate synthase B37_02566 ENOG4105CM2 brancheD-chain amino acid aminotransferase B37_02568 ENOG4107R37 Glutamate dehydrogenase B37_02571 ENOG4108MDF Phage Portal Protein B37_02572 ENOG4105IG6 Phage terminase, large subunit B37_02585 ENOG4105M59 Phosphodiesterase, mj0936 family B37_02586 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) B37_02587 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) B37_02588 ENOG4108XJQ germination protein B37_02589 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) B37_02590 ENOG41067TZ transcriptional regulator, MarR family B37_02591 ENOG4105PFC Transcriptional regulator B37_02592 ENOG4105EMU Dehydrogenase B37_02594 ENOG4105E33 succinate dehydrogenase B37_02596 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit B37_02598 ENOG4105CFH Aspartokinase B37_02599 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) B37_02600 ENOG4105K63 Thioredoxin B37_02601 ENOG4105C10 Electron transfer flavoprotein B37_02602 ENOG4105BZJ Electron transfer flavoprotein B37_02603 ENOG41060WC Enoyl-CoA hydratase B37_02604 ENOG4107Z3H Transcriptional regulator, TetR family B37_02605 ENOG4105CEY Amp-dependent synthetase and ligase B37_02607 ENOG4105C98 muts2 protein B37_02608 ENOG4105DCG PHP domain protein B37_02610 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) B37_02611 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B37_02613 ENOG4105DQ6 Transposase B37_02617 ENOG4108IUZ ABC transporter B37_02620 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) B37_02621 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) B37_02622 ENOG4108RWN rrna methyltransferase B37_02623 ENOG41067MF small acid-soluble spore protein B37_02627 ENOG4105DRS transport system, permease B37_02630 ENOG4108MDK Dehydrogenase B37_02631 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase B37_02632 ENOG4105EF1 ribulokinase B37_02633 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) B37_02634 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase B37_02635 ENOG4105CN9 Peptidase m42 family protein B37_02637 ENOG410696E Membrane B37_02638 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) B37_02639 ENOG4105VJV 50s ribosomal protein L35 B37_02640 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) B37_02641 ENOG41067MG lrgb family B37_02643 ENOG4105DGI Alkaline phosphatase B37_02644 ENOG4105DY9 regulatoR B37_02645 ENOG4108HRK Histidine kinase B37_02647 ENOG4105U0R haloacid dehalogenase-like hydrolase B37_02648 ENOG4105C22 threonyL-tRNA synthetase B37_02649 ENOG4108TDW sporulation protein YtxC B37_02653 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) B37_02655 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B37_02656 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B37_02657 ENOG4108NR7 pectate lyase B37_02658 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) B37_02660 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) B37_02661 ENOG4105C2M dna polymerase I B37_02662 ENOG4105BZU Histidine kinase B37_02663 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B37_02664 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B37_02665 ENOG4108HMX isocitrate dehydrogenase (NADP) B37_02666 ENOG4105BZN citrate synthase B37_02667 ENOG4108VMM UPF0756 membrane protein B37_02668 ENOG4108REF Sporulation integral membrane protein ytvi B37_02669 ENOG4105FS0 cytoplasmic membrane protein B37_02670 ENOG4105CA9 Pyruvate kinase B37_02671 ENOG4105CTQ phosphohexokinase B37_02672 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) B37_02674 ENOG4105C6K Malic enzyme B37_02675 ENOG4105C0B DNA polymerase III (alpha subunit) B37_02676 ENOG4105VV2 B37_02678 ENOG4106EVM B37_02679 ENOG4105SFS phosphoesterase RecJ domain protein B37_02682 ENOG4105U3E Transcriptional regulator B37_02683 ENOG4105E8R UPF0173 metal-dependent hydrolase B37_02686 ENOG4105CH7 arginosuccinase B37_02687 ENOG4105CDH Citrulline--aspartate ligase B37_02688 ENOG4105EPU Molybdenum cofactor synthesis domain protein B37_02689 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) B37_02691 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) B37_02692 ENOG4105KBJ sporulation protein ytfj B37_02694 ENOG4105VK3 rdd domain containing protein B37_02695 ENOG4105D07 Signal peptide peptidase, SppA B37_02697 ENOG4105CW7 secretion protein, HlyD family B37_02700 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B37_02702 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) B37_02706 ENOG4105DQ6 Transposase B37_02709 ENOG4105U5Y Transcriptional regulator B37_02711 ENOG4105BZU Histidine kinase B37_02712 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) B37_02715 ENOG4105KAF membrAne B37_02716 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein B37_02719 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B37_02721 ENOG4105F1V Acetoin utilization protein B37_02722 ENOG4105W87 Cbs domain B37_02723 ENOG4105DGU Histone deacetylase B37_02724 ENOG4105ER2 Ompa motb domain protein B37_02725 ENOG4107R0U MotA TolQ exbB proton channel B37_02726 ENOG4105ETE Transcriptional regulator (LacI family B37_02727 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase B37_02733 ENOG4105DFU Cell wall formation (By similarity) B37_02735 ENOG4108VDD TRNA binding domain protein B37_02738 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ B37_02741 ENOG4105C6K Malic enzyme B37_02742 ENOG4105C8F Beta-lactamase domain protein B37_02743 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) B37_02745 ENOG4108V15 phosphotransferase enzyme family B37_02746 ENOG4108IUM Glycogen debranching enzyme B37_02747 ENOG4108IUM Glycogen debranching enzyme B37_02750 ENOG4107F58 2'-5' rna ligase B37_02751 ENOG4105C6T cysteine synthase B37_02753 ENOG4107QSE Dipeptidase B37_02754 ENOG4105C7N Xanthine uracil vitamin C permease B37_02755 ENOG4105YW5 deoR family transcriptional regulator B37_02758 ENOG4105CBX hi0933 family B37_02759 ENOG4105C94 Transporter B37_02761 ENOG41085GJ domain protein B37_02765 ENOG4105MU9 integral membrane protein B37_02766 ENOG4105DDC Oxidoreductase domain protein B37_02768 ENOG4105F5H Glycosyl Hydrolase Family 88 B37_02770 ENOG41075H3 AraC family transcriptional regulator B37_02772 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component B37_02774 ENOG4105NTD Inherit from COG: Hydrolase B37_02776 ENOG4107V2S Transcriptional regulator B37_02777 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase B37_02778 ENOG4105C8T Leucyl-tRNA synthetase B37_02780 ENOG410605W Major Facilitator B37_02781 ENOG4105D01 (LipO)protein B37_02782 ENOG4106UBQ B37_02783 ENOG4107R34 abc transporter permease protein B37_02784 ENOG4105C19 ABC transporter B37_02786 ENOG4105DVE abc transporter atp-binding protein B37_02787 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B37_02790 ENOG4105N5T Radical SAM Protein B37_02794 ENOG4105E8V Alpha Beta Hydrolase Fold protein B37_02795 ENOG4108Z0R Transferase B37_02796 ENOG4105YVM Phosphoesterase, PA-phosphatase related B37_02797 ENOG4105BZF Glycosyl transferase (Group 1 B37_02798 ENOG4105CAQ asparagine synthetase B37_02799 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP B37_02801 ENOG4105CK2 sodium dicarboxylate symporter B37_02804 ENOG4105D2X ABC transporter substrate-binding protein B37_02806 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component B37_02810 ENOG4108RMU ferritin dps family protein B37_02813 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) B37_02814 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) B37_02815 ENOG4108V2W Carbonate dehydratase B37_02816 ENOG4105CKI cobalamin synthesis protein B37_02817 ENOG4105DSE periplasmic solute binding protein B37_02823 ENOG4105DTQ mandelate racemase muconate lactonizing B37_02824 ENOG4105CEY Amp-dependent synthetase and ligase B37_02825 ENOG4108IPT Naphthoate synthase B37_02826 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) B37_02827 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) B37_02828 ENOG4105E4F Isochorismate synthase B37_02829 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase B37_02833 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) B37_02835 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) B37_02836 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) B37_02861 ENOG4105CMD Transcriptional regulator, GntR family B37_02862 ENOG4105N67 Proton-coupled thiamine transporter YuaJ B37_02868 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) B37_02870 ENOG4105CZN Potassium uptake protein B37_02872 ENOG4106DF1 B37_02873 ENOG4108VNY MOSC domain protein B37_02874 ENOG4108JB8 alcohol dehydrogenase B37_02875 ENOG4105C26 Dehydrogenase B37_02876 ENOG4105TRT Transcriptional regulator B37_02878 ENOG4105JQZ Methyltransferase B37_02879 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B37_02880 ENOG4105F0F Oxalate decarboxylase B37_02892 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) B37_02898 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B37_02900 ENOG4105EE0 oxidoreductase B37_02901 ENOG4108Z0Z intracellular protease Pfpi family B37_02902 ENOG4105C8Q Methyl-accepting chemotaxis B37_02903 ENOG4105C8Q Methyl-accepting chemotaxis B37_02904 ENOG4105C8Q Methyl-accepting chemotaxis B37_02905 ENOG4105C8Q Methyl-accepting chemotaxis B37_02907 ENOG4105EA8 2-Nitropropane dioxygenase B37_02908 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme B37_02913 ENOG4105C37 (CBS) domain B37_02916 ENOG4107PBV potassium channel B37_02917 ENOG4107PBV potassium channel B37_02919 ENOG410900G Protein of unknown function (DUF421) B37_02921 ENOG4105KNA -acetyltransferase B37_02929 ENOG4107EV6 Inherit from COG: YD repeat protein B37_02936 ENOG41068G1 B37_02938 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj B37_02940 ENOG4108FKH Transglycosylase SLT domain B37_02950 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B37_02953 ENOG4105CAR Terminase, large subunit B37_02977 ENOG4107QYV phosphohexose isomerase B37_02978 ENOG4107QW4 alcohol dehydrogenase B37_02979 ENOG4105WG9 Conserved Protein B37_02981 ENOG4105CHM Aminotransferase B37_02982 ENOG4108ZB6 transcriptional regulator AsnC family B37_02983 ENOG4108MUZ hydrolase B37_02986 ENOG4105C87 Aminotransferase class I and II B37_02988 ENOG4105Y38 Kinase-associated protein B B37_02991 ENOG4105BZ4 penicillin-binding protein B37_02992 ENOG4105KIR Thiol-disulfide oxidoreductase dcc B37_02995 ENOG4108MRH transcriptional regulatory protein B37_02996 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B37_02997 ENOG4107ZTW SNARE associated Golgi B37_02998 ENOG4105DJ4 phosphatidylserine decarboxylase B37_03001 ENOG4105D65 subunit l B37_03002 ENOG4105HC0 Na H antiporter B37_03003 ENOG4108ZE9 Monovalent cation H antiporter subunit C B37_03004 ENOG4108JPZ Monovalent cation H antiporter subunit D B37_03005 ENOG4105SC1 monovalent cation H antiporter subunit E B37_03007 ENOG4105KJM monovalent cation h antiporter subunit g B37_03008 ENOG4105KA0 thioesterase Superfamily protein B37_03010 ENOG4105BZU Histidine kinase B37_03016 ENOG4105D58 Diguanylate phosphodiesterase B37_03017 ENOG4105DAP Nicotinate phosphoribosyltransferase B37_03022 ENOG4105C02 permease B37_03023 ENOG4108Z40 Transcriptional regulator B37_03027 ENOG410904N short-chain dehydrogenase reductase B37_03034 ENOG4105BZG amino acid carrier protein B37_03035 ENOG4108K8K Transcriptional regulator B37_03036 ENOG4105DCF alanine dehydrogenase B37_03041 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) B37_03043 ENOG41069ER domain protein B37_03045 ENOG4105CEP NADH dehydrogenase B37_03046 ENOG4105CAY ferredoxin--nadp reductase B37_03049 ENOG4108YM7 Gcn5-related n-acetyltransferase B37_03050 ENOG4108YX9 iron--sulfur cluster insertion protein erpA B37_03055 ENOG4108ZMX Domain of unknown function (DU1801) B37_03058 ENOG4105PY6 Phenolic acid decarboxylase B37_03061 ENOG41083MR nifu domain-containing protein B37_03062 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein B37_03063 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) B37_03064 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) B37_03065 ENOG4105D6E homoserine dehydrogenase B37_03066 ENOG4105C5I Dehydrogenase B37_03068 ENOG4108W5N phosphatidylglycerophosphatase a B37_03069 ENOG4105D4U had-superfamily hydrolase, subfamily iia B37_03071 ENOG4105MMD transcriptional regulator B37_03072 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) B37_03073 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) B37_03074 ENOG4105FAA peptidase M23 B37_03076 ENOG4105C8J )-transporter B37_03077 ENOG4108YTE sporulation protein YunB B37_03078 ENOG4105KZD Domain of unknown function (DUF1805) B37_03079 ENOG4107R8B 5'-nucleotidase B37_03081 ENOG4105I3N Conserved Protein B37_03082 ENOG4105IIP Membrane B37_03083 ENOG4105W1N transcriptional regulator B37_03085 ENOG4105C5R Aminotransferase B37_03087 ENOG4105G9B Transcriptional regulator B37_03090 ENOG4108I0Q anthranilate phosphoribosyltransferase B37_03091 ENOG4108I0Q anthranilate phosphoribosyltransferase B37_03092 ENOG4108K8S endonuclease I B37_03094 ENOG4107VFR oxidoreductase B37_03099 ENOG4105DIW FeS assembly protein SUFB B37_03100 ENOG4108UNV SUF system FeS assembly protein, NifU family B37_03101 ENOG4105C9B Cysteine desulfurase B37_03102 ENOG4105JRK feS assembly protein SufD B37_03103 ENOG4105C3K feS assembly ATPase SufC B37_03104 ENOG4105PGM cation diffusion facilitator family transporter B37_03106 ENOG4105D01 (LipO)protein B37_03107 ENOG4108UMI ABC transporter, permease B37_03108 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B37_03113 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) B37_03114 ENOG41080E8 Transcriptional regulator, Spx MgsR family B37_03115 ENOG4105C1G acyl-Coa dehydrogenase B37_03116 ENOG4105CHU acetyl-coa acetyltransferase B37_03123 ENOG4105E0A ABC, transporter B37_03124 ENOG4108IHU transport system permease protein B37_03125 ENOG4105DQ5 transport system permease protein B37_03126 ENOG4108MES Periplasmic binding protein B37_03129 ENOG4105DZ1 carboxypeptidase B37_03130 ENOG4105E1F short-chain dehydrogenase reductase B37_03131 ENOG4105HUF DNA protection during starvation protein B37_03132 ENOG4105C0H protease B37_03134 ENOG4105F3H Histidine kinase B37_03136 ENOG41067SE Tetr family transcriptional regulator B37_03137 ENOG4105C9Q fumarate hydratase class II B37_03143 ENOG4105WH1 Two component transcriptional regulator luxr family B37_03144 ENOG4105ENE Histidine kinase B37_03147 ENOG41087YS Phage shock protein A B37_03150 ENOG4108WBT adenosyltransferase B37_03151 ENOG4105CHR reductase B37_03152 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) B37_03153 ENOG4105C0A alcohol dehydrogenase B37_03154 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B37_03155 ENOG4105E0A ABC, transporter B37_03156 ENOG4105EHG Permease protein B37_03157 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) B37_03158 ENOG4105DRR Transcriptional regulator, GntR family B37_03159 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B37_03160 ENOG4108RPX mosc domain containing protein B37_03161 ENOG4105DND Transcriptional regulator B37_03163 ENOG4105CTX dehydratase B37_03164 ENOG4107QZW Altronate oxidoreductase B37_03165 ENOG4107KJX Transcriptional regulator B37_03166 ENOG4105CT4 transporter B37_03167 ENOG4105D2H Uronic isomerase B37_03169 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B37_03170 ENOG4105E0A ABC, transporter B37_03171 ENOG4105EHG Permease protein B37_03172 ENOG4105DQ5 transport system permease protein B37_03173 ENOG4105D5Q Arginine ornithine antiporter B37_03174 ENOG4107K5X Membrane-bound metal-dependent hydrolase B37_03175 ENOG4107QZ2 Sulfatase B37_03178 ENOG4105EVU fructokinase B37_03179 ENOG4107EPV Aminotransferase class V B37_03181 ENOG4105EEM helicase B37_03182 ENOG4105EN6 Membrane B37_03183 ENOG4105RHY Pfam:UPF0157 B37_03185 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B37_03187 ENOG4107ZQN disulfide bond B37_03188 ENOG4105C59 p-type ATPase B37_03189 ENOG4108JE9 extracellular solute-binding protein family 1 B37_03190 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component B37_03191 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component B37_03192 ENOG4105CJQ hydrolase, family 31 B37_03194 ENOG4105DIK (ABC) transporter B37_03195 ENOG4105CC5 ABC transporter B37_03196 ENOG4105DSE periplasmic solute binding protein B37_03200 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) B37_03201 ENOG4105DM4 PTS System B37_03205 ENOG4105C59 p-type ATPase B37_03206 ENOG410681U heavy metal transport detoxification protein B37_03207 ENOG4105VPX protein, conserved in bacteria B37_03208 ENOG4107RKG DJ-1/PfpI family B37_03209 ENOG4105E98 transcriptional regulator DeoR family B37_03210 ENOG4105DET Rhamnulokinase B37_03211 ENOG4105C9F isomerase B37_03214 ENOG4105F27 Major Facilitator B37_03217 ENOG410625E B37_03218 ENOG4106A3M Cytochrome p-450 B37_03222 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B37_03223 ENOG4105D9R oxidoreductase B37_03226 ENOG4105C72 UPF0176 protein B37_03228 ENOG4106DF4 Sigma-70, region 4 B37_03230 ENOG4105F0F Oxalate decarboxylase B37_03241 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) B37_03242 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) B37_03244 ENOG4105XZU Preprotein translocase, subunit SecG B37_03249 ENOG4105R40 Glycine betaine carnitine choline B37_03250 ENOG4108HQR Glycine betaine B37_03251 ENOG4105E90 ABC transporter B37_03252 ENOG4108IJ8 ABC transporter B37_03253 ENOG4107HG4 Transcriptional regulator B37_03254 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein B37_03256 ENOG4105T65 Membrane-associated protein B37_03258 ENOG4108MES Periplasmic binding protein B37_03260 ENOG4108V4B ThiJ pfpI B37_03261 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) B37_03262 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) B37_03263 ENOG4105CP7 Triose-phosphate isomerase B37_03264 ENOG4105BZA Phosphoglycerate kinase B37_03265 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B37_03267 ENOG4105DEN Luciferase family B37_03274 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B37_03275 ENOG4105JXH GntR family transcriptional regulator B37_03276 ENOG4105DAA L-lactate B37_03277 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B37_03279 ENOG4108ZPC Polysaccharide pyruvyl transferase B37_03280 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B37_03281 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family B37_03282 ENOG4105D3Q Sugar transferase B37_03284 ENOG4105K64 Glycosyl transferase, family 2 B37_03286 ENOG4107QRS glycosyltransferase group 2 family protein B37_03287 ENOG41068W6 Capsular polysaccharide biosynthesis protein B37_03288 ENOG4108KMV Glycosyl transferase (Group 1 B37_03289 ENOG4105K64 Glycosyl transferase, family 2 B37_03290 ENOG4108PQP glycosyl transferase group 1 B37_03292 ENOG4108QV3 biosynthesis protein B37_03293 ENOG4105HTX biosynthesis protein B37_03295 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B37_03296 ENOG4108I5G Major Facilitator superfamily B37_03298 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) B37_03299 ENOG4107S2N Type III effector Hrp-dependent B37_03301 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B37_03304 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B37_03305 ENOG4105EDQ levansucrase EC 2.4.1.10 B37_03306 ENOG4108HKT sucrose-6-phosphate hydrolase B37_03309 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B37_03310 ENOG4108URH decarboxylase B37_03311 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain B37_03312 ENOG4107TVP HD domain protein B37_03313 ENOG4105CHH sulfate transporter B37_03314 ENOG4108V2W Carbonate dehydratase B37_03315 ENOG4105C5I Dehydrogenase B37_03316 ENOG4108SQ9 flavin reductase domain protein, FMN-binding B37_03317 ENOG4108ZHR arsR family transcriptional regulator B37_03320 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B37_03321 ENOG4105KRI phosphocarrier protein (HPr B37_03322 ENOG4105CIE May be required for sporulation (By similarity) B37_03323 ENOG4105CHW UPF0052 protein B37_03324 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) B37_03325 ENOG4108Z4K mutator MutT protein B37_03326 ENOG4105C3M thioredoxin reductase B37_03329 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase B37_03330 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) B37_03331 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase B37_03332 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) B37_03333 ENOG4105ECC imidazole-glycerol-phosphate dehydratase B37_03334 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) B37_03335 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) B37_03336 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) B37_03338 ENOG4108E16 pectate lyase B37_03339 ENOG4108S4C acetyltransferase B37_03340 ENOG4107XGZ Hydrolase B37_03341 ENOG4105HKU nucleoside recognition domain-containing protein B37_03343 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) B37_03344 ENOG410834F Transcriptional regulator B37_03345 ENOG4105C0R drug resistance transporter emrb qaca subfamily B37_03346 ENOG41088CQ domain protein B37_03347 ENOG41086DT Membrane protein of unknown function B37_03348 ENOG41067S9 phage shock protein C, PspC B37_03349 ENOG4108PY7 B37_03353 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B37_03354 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) B37_03359 ENOG4105CN1 protease B37_03360 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) B37_03362 ENOG4105CRP Part of the ABC transporter FtsEX involved in B37_03363 ENOG4105CAK Cell division ATP-binding protein ftsE B37_03366 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) B37_03367 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving B37_03368 ENOG4105MS2 ribosomal subunit Interface protein B37_03371 ENOG4105MQ3 flagellar protein FliS B37_03372 ENOG4107RT6 flagellar hook-associated B37_03373 ENOG41083S7 flagellar protein FlaG B37_03374 ENOG4105I03 Flagellin B37_03375 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) B37_03376 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) B37_03377 ENOG4105MKD B37_03378 ENOG4105DTJ flagellar hook-associated protein B37_03379 ENOG4105E1Q flagellar hook-associated protein B37_03382 ENOG4105RU3 B37_03386 ENOG4105WH1 Two component transcriptional regulator luxr family B37_03387 ENOG4105BZU Histidine kinase B37_03388 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein B37_03389 ENOG4108KGH TRANSCRIPTIONal B37_03391 ENOG4105ESV Glycosyl transferase, family 4 B37_03392 ENOG4107EF8 Glycosyl transferase (Group 1 B37_03395 ENOG4105QZI O-Antigen Polymerase B37_03396 ENOG4105C1B dTDP-glucose 4-6-dehydratase B37_03397 ENOG4105C6Y Udp-glucose 6-dehydrogenase B37_03398 ENOG4107RA4 Glycosyl transferase (Group 1 B37_03399 ENOG4105PSV Polysaccharide Biosynthesis Protein B37_03400 ENOG4105D3Q Sugar transferase B37_03401 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B37_03402 ENOG4105JFG SpoIID LytB domain protein B37_03404 ENOG4108KGH TRANSCRIPTIONal B37_03405 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase B37_03406 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B37_03407 ENOG4105EY8 ABC transporter B37_03410 ENOG4107SJB teichoic acid biosynthesis B37_03411 ENOG4107SJB teichoic acid biosynthesis B37_03412 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase B37_03414 ENOG4107RZX Teichoic acid biosynthesis protein B37_03416 ENOG4105DG6 mannose-6-phosphate isomerase B37_03418 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase B37_03419 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) B37_03420 ENOG4108UHU Aldolase B37_03421 ENOG4105D7K pfkb domain protein B37_03422 ENOG4108M60 Transcriptional regulator B37_03424 ENOG4105CHR reductase B37_03425 ENOG4105E2A Dehydrogenase B37_03427 ENOG4105C54 Major Facilitator superfamily B37_03428 ENOG4108KGH TRANSCRIPTIONal B37_03429 ENOG4105J7I hydrolase B37_03430 ENOG4105K4H Nlp p60 protein B37_03432 ENOG4105PNM synthesis protein B37_03434 ENOG4105N98 Capsule biosynthesis protein capB B37_03435 ENOG4105ETE Transcriptional regulator (LacI family B37_03436 ENOG4108RVA ribokinase B37_03437 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) B37_03438 ENOG4105C2J ABC transporter B37_03439 ENOG4105CNN ABC, transporter B37_03440 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator B37_03441 ENOG4107FQX Alpha-acetolactate decarboxylase B37_03443 ENOG4107RSM transcriptional regulator B37_03445 ENOG4105DQ6 Transposase B37_03446 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) B37_03448 ENOG4105CAH Chromate B37_03449 ENOG4105FGV Chromate B37_03450 ENOG4108RB3 Capsular polysaccharide biosynthesis protein B37_03451 ENOG4105HTX biosynthesis protein B37_03453 ENOG4105KBK Zinc finger, swim domain protein B37_03454 ENOG4105C0D helicase B37_03456 ENOG410667J hydrolase B37_03457 ENOG4105E98 transcriptional regulator DeoR family B37_03459 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase B37_03460 ENOG4105VI0 Pts system, glucitol sorbitol-specific B37_03461 ENOG4105DZY Pts system, glucitol sorbitol-specific B37_03462 ENOG410787A Pts system, glucitol sorbitol-specific B37_03464 ENOG4105DKT Transcriptional regulator B37_03465 ENOG4105Z8H single-stranded DNA-binding protein B37_03469 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) B37_03470 ENOG4105CGA flagellar basal-body rod protein FlgG B37_03472 ENOG4105DFF Rod shape-determining protein mreb B37_03473 ENOG4105MT0 Sporulation transcriptional regulator spoiiid B37_03474 ENOG4107MII Sugar-specific transcriptional regulator TrmB B37_03475 ENOG4105CZM Major Facilitator B37_03476 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase B37_03477 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase B37_03479 ENOG4108NA0 Uncharacterized conserved protein (COG2071) B37_03480 ENOG41080XP Cbs domain B37_03481 ENOG41080XQ Signal transduction protein with cbs domains B37_03483 ENOG4105C37 (CBS) domain B37_03484 ENOG4105BZU Histidine kinase B37_03488 ENOG4105FRN stage II sporulation protein B37_03489 ENOG4107TCE N-acetyltransferase B37_03491 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B37_03493 ENOG4105C0R drug resistance transporter emrb qaca subfamily B37_03494 ENOG4105WQT MbtH domain protein B37_03495 ENOG4105CEY Amp-dependent synthetase and ligase B37_03496 ENOG4105WQI isochorismatase B37_03497 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase B37_03498 ENOG4105E4F Isochorismate synthase B37_03499 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase B37_03500 ENOG4105NIV Esterase B37_03504 ENOG410874W AraC family transcriptional regulator B37_03506 ENOG4108RYK Nad-dependent epimerase dehydratase B37_03507 ENOG4108Z40 Transcriptional regulator B37_03510 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B37_03511 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B37_03512 ENOG4105FCD Major Facilitator B37_03513 ENOG4108HIZ formate dehydrogenase alpha subunit B37_03514 ENOG4108TF4 von Willebrand factor, type A B37_03517 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B37_03519 ENOG4106778 Protein of unknown function (DUF1146) B37_03520 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) B37_03521 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) B37_03522 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) B37_03523 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) B37_03524 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) B37_03527 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) B37_03529 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) B37_03530 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) B37_03531 ENOG4108UIC UPF0340 protein B37_03532 ENOG4108YZG isomerase B37_03533 ENOG4107WAU Protein tyrosine phosphatase B37_03534 ENOG410815N Probably functions as a manganese efflux pump (By similarity) B37_03535 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B37_03537 ENOG4108ZXQ stage ii sporulation protein r B37_03540 ENOG4105TRI Hydrolase B37_03543 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) B37_03544 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) B37_03545 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase B37_03547 ENOG4107TT2 Auxin Efflux Carrier B37_03548 ENOG4105C6K Malic enzyme B37_03549 ENOG4107104 thymidine kinase B37_03550 ENOG41082DI 50s ribosomal protein l31 B37_03551 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) B37_03552 ENOG4105CBT Fructose-1,6-bisphosphatase B37_03553 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B37_03554 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway B37_03555 ENOG4105D2N Aldolase B37_03556 ENOG410812K response regulator receiver protein B37_03559 ENOG4105DQ6 Transposase B37_03560 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) B37_03562 ENOG4105C1G acyl-Coa dehydrogenase B37_03563 ENOG4105C1G acyl-Coa dehydrogenase B37_03564 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B37_03566 ENOG4105DF6 Fe-S oxidoreductase B37_03569 ENOG4105C75 arginyL-tRNA synthetase B37_03570 ENOG410684U Domain of unknown function (DUF1934) B37_03571 ENOG4105CYW agmatinase B37_03572 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) B37_03574 ENOG4105BZ4 penicillin-binding protein B37_03575 ENOG4108XFG YwhD family B37_03576 ENOG4108Z4T Peptidase M50 B37_03577 ENOG41069HH 4-oxalocrotonate tautomerase B37_03580 ENOG4105DCI Phosphohydrolase B37_03582 ENOG4108VCI transcription factor, rsfa family B37_03584 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) B37_03586 ENOG4105D2S major facilitator superfamily B37_03591 ENOG4108FUF Transcriptional regulator, IclR family B37_03593 ENOG4108IJ2 phosphate acetyltransferase B37_03594 ENOG4107JTW chlorite dismutase B37_03596 ENOG4105CZN Potassium uptake protein B37_03600 ENOG4105CJ1 ABC, transporter B37_03606 ENOG4105C26 Dehydrogenase B37_03607 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) B37_03608 ENOG4108RJ9 Glycosyl transferase, family 2 B37_03609 ENOG4105DWF phosphomethylpyrimidine kinase B37_03612 ENOG4105C5Y PTS System B37_03615 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin B37_03617 ENOG4105DEN Luciferase family B37_03619 ENOG4108DBC nitroreductase B37_03623 ENOG4105DWD nucleoside recognition domain protein B37_03635 ENOG41060D1 Quinol oxidase B37_03637 ENOG4105BZ9 Cytochrome C oxidase, subunit I B37_03638 ENOG4105E2S oxidase) subunit II B37_03639 ENOG4105CMR udp-glucose 4-epimerase B37_03643 ENOG4108WS4 fmn reductase B37_03646 ENOG4105CMG Carbohydrate kinase B37_03647 ENOG4105C93 Xylose Isomerase B37_03649 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) B37_03650 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase B37_03651 ENOG4105CMU LysR family (Transcriptional regulator B37_03655 ENOG41067MG lrgb family B37_03657 ENOG4105CK7 Sodium proline symporter B37_03658 ENOG4105DR4 Methyltransferase B37_03660 ENOG4105C5I Dehydrogenase B37_03661 ENOG4105X1N Glycosyl transferase family 8 B37_03663 ENOG4105ENE Histidine kinase B37_03664 ENOG4108VB1 regulatoR B37_03665 ENOG4105EYF MMPL domain protein B37_03667 ENOG4105DJB Major Facilitator Superfamily B37_03668 ENOG4105CXK mandelate racemase muconate lactonizing B37_03669 ENOG4108UHU Aldolase B37_03670 ENOG4105D7K pfkb domain protein B37_03672 ENOG4105IIU Aminopeptidase B37_03673 ENOG41080V3 Major Facilitator superfamily B37_03678 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) B37_03679 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein B37_03680 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) B37_03681 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B37_03682 ENOG4105CM2 brancheD-chain amino acid aminotransferase B37_03684 ENOG4105F8D glycoside hydrolase family 4 B37_03685 ENOG4105VCP PTS System B37_03686 ENOG4105CK1 PTS System B37_03687 ENOG4105VZJ PTS System B37_03688 ENOG4105EMD TRANSCRIPTIONal B37_03690 ENOG4108VX5 3-methyladenine DNA glycosylase B37_03693 ENOG4105DXD 2-methylcitrate dehydratase B37_03694 ENOG4105CR4 methylisocitrate lyase B37_03697 ENOG4105BZ1 (ABC) transporter B37_03698 ENOG4107TDE lipolytic protein G-D-S-L family B37_03701 ENOG4105C2C drug resistance transporter, Bcr CflA B37_03703 ENOG4105DA5 (ABC) transporter B37_03704 ENOG41069JR B37_03709 ENOG4105CH6 catalase B37_03711 ENOG4105G5W regulator Fur family B37_03712 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B37_03713 ENOG4108TU7 Inherit from COG: (ABC) transporter B37_03714 ENOG4105CJ1 ABC, transporter B37_03717 ENOG4105CJ1 ABC, transporter B37_03727 ENOG4108J20 pectate lyase B37_03728 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) B37_03729 ENOG4108JJ8 (ABC) transporter B37_03730 ENOG4108JJ9 ABC, transporter B37_03731 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B37_03732 ENOG4105C4M (Ubiquinol oxidase) subunit I B37_03733 ENOG4108QTI )-transporter B37_03736 ENOG4105DFD Na H antiporter B37_03737 ENOG4108IJ0 Aspartate ammonia-lyase B37_03738 ENOG4105HDK L-asparaginase B37_03739 ENOG4108IMY Transcriptional regulator B37_03740 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) B37_03748 ENOG4107BJW polysaccharide deacetylase B37_03749 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B37_03750 ENOG4107QZ7 Cellulose synthase catalytic subunit B37_03752 ENOG4105DQ6 Transposase B37_03753 ENOG4105D2K citrate carrier protein B37_03754 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B37_03755 ENOG4105X3H Excalibur domain protein B37_03757 ENOG4105E0M Sulfatase B37_03759 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) B37_03761 ENOG4105CEU Arginine dihydrolase B37_03762 ENOG4105DBV ornithine carbamoyltransferase B37_03764 ENOG4105C5B carbamate kinase B37_03766 ENOG4105CS2 ec 3.2.1.21 B37_03767 ENOG4105CK1 PTS System B37_03769 ENOG4105JVQ RNA Polymerase B37_03774 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) B37_03775 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B37_03777 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) B37_03778 ENOG4105ETE Transcriptional regulator (LacI family B37_03783 ENOG4105EDW glycosyl transferase, family 39 B37_03784 ENOG4105CKK Glycosyl transferase, family 2 B37_03785 ENOG4105CMR udp-glucose 4-epimerase B37_03791 ENOG4105CH6 catalase B37_03792 ENOG4105CH6 catalase B37_03794 ENOG4105CS2 ec 3.2.1.21 B37_03795 ENOG4105C5Y PTS System B37_03796 ENOG4105CID antiterminator B37_03797 ENOG4108W7F transporter, permease B37_03798 ENOG4108JJB ABC transporter B37_03799 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein B37_03800 ENOG4105ETU transcriptional activator (TenA B37_03803 ENOG4107QP3 malate synthase g B37_03805 ENOG4105EDW glycosyl transferase, family 39 B37_03807 ENOG4105C19 ABC transporter B37_03808 ENOG4105EWM Histidine kinase B37_03810 ENOG4105CS2 ec 3.2.1.21 B37_03811 ENOG4105C5Y PTS System B37_03813 ENOG4107QHE Choloylglycine hydrolase B37_03816 ENOG4106Z5D Glycoside Hydrolase Family 43 B37_03822 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) B37_03823 ENOG4105D9N nucleoside B37_03824 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) B37_03825 ENOG4107RHR regulatoR B37_03829 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) B37_03830 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) B37_03831 ENOG4107R8N Glycosyl transferase, family 2 B37_03833 ENOG4105JKW Valine--pyruvate aminotransferase B37_03838 ENOG4105D2N Aldolase B37_03839 ENOG4107TRN Xylose isomerase domain protein TIM barrel B37_03840 ENOG4105F0H myo-inositol catabolism protein B37_03841 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) B37_03843 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) B37_03844 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) B37_03845 ENOG4105D7K pfkb domain protein B37_03846 ENOG4105DH8 myo-inositol catabolism B37_03847 ENOG4105C26 Dehydrogenase B37_03849 ENOG4105CPC Aldo Keto reductase B37_03850 ENOG4107VXM glycerophosphoryl diester phosphodiesterase B37_03851 ENOG4105CXY transporter B37_03852 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) B37_03853 ENOG4105C5H ABC transporter B37_03854 ENOG410667J hydrolase B37_03857 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) B37_03859 ENOG4108V5C ABC transporter B37_03864 ENOG4105H93 Acyltransferase family B37_03870 ENOG4105EC8 Methyl-accepting chemotaxis B37_03871 ENOG4105BZG amino acid carrier protein B37_03872 ENOG4105DCF alanine dehydrogenase B37_03875 ENOG4105EG2 ABC transporter, permease B37_03877 ENOG4107FKK extracellular solute-binding protein family 1 B37_03879 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) B37_03880 ENOG4105CMR udp-glucose 4-epimerase B37_03881 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase B37_03882 ENOG4105E2R ROK family B37_03884 ENOG4105CMG Carbohydrate kinase B37_03887 ENOG4108EKI Dehydrogenase B37_03888 ENOG4105D3R alkyl hydroperoxide reductase B37_03889 ENOG4108JU3 Alkyl hydroperoxide reductase B37_03894 ENOG4108M15 ABC transporter B37_03895 ENOG4105KCT ABC transporter B37_03896 ENOG4105BZU Histidine kinase B37_03897 ENOG4105BZU Histidine kinase B37_03904 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) B37_03907 ENOG4105WQG acetyltransferase B37_03910 ENOG4105C0H protease B37_03911 ENOG4105Q2H domain protein B37_03914 ENOG4105BZU Histidine kinase B37_03915 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B37_03921 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis B37_03923 ENOG4105CDU Replicative dna helicase B37_03927 ENOG4105DJ2 Major Facilitator Superfamily B37_03928 ENOG4105CE4 GlcNAc 6-P deacetylase B37_03929 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) B37_03930 ENOG4105FDP GntR family transcriptional regulator B37_03931 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate B37_03933 ENOG4105K9Q Binds to the 23S rRNA (By similarity) B37_03934 ENOG4105BZR domain protein B37_03935 ENOG4108XMW Membrane B37_03937 ENOG4107YZX Universal stress protein B37_03938 ENOG4105CHH sulfate transporter B37_03940 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) B37_03941 ENOG4108UUM single-stranded DNA-binding protein B37_03942 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) B37_03943 ENOG4105C3G gtp-binding protein B37_03944 ENOG4105VDK protein, conserved in bacteria B37_03946 ENOG4108ZDA Sporulation protein YyaC B37_03947 ENOG4105FA0 parb-like partition protein B37_03948 ENOG4107QJE Chromosome Partitioning Protein B37_03949 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) B37_03951 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) B37_03953 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) B37_03954 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) B37_03957 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) B37_03958 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) B37_03959 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B37_03960 ENOG410848D S4 domain protein YaaA B37_03961 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) B37_03962 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B37_03963 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B37_03970 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) B37_03972 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) B37_03973 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) B37_03974 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) B37_03975 ENOG4105BZW Glycerate kinase B37_03976 ENOG4107QQ0 gntp family B37_03977 ENOG4107QQ0 gntp family B37_03978 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR B37_03981 ENOG4105ZMH deoxynucleoside kinase B37_03983 ENOG4105VRS hydrolase family 18 B37_03984 ENOG4105GTG Isochorismatase B37_03985 ENOG4108Z6B deaminase B37_03986 ENOG4105C6E dna polymerase iii B37_03987 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) B37_03988 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) B37_03990 ENOG41067KS pro-sigma K processing B37_03998 ENOG4105CDW Resistance protein B37_03999 ENOG4105CXN decarboxylase B37_04000 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) B37_04001 ENOG4105X0R protein from nitrogen regulatory protein P-II B37_04002 ENOG4105XVJ Protein of unknown function (DUF327) B37_04003 ENOG4105FA2 dna polymerase iii B37_04004 ENOG4105MA4 psp1 domain protein B37_04005 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) B37_04006 ENOG41060K3 Methyltransferase B37_04007 ENOG4105VC4 domain protein B37_04008 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) B37_04009 ENOG4105KRN Transcriptional regulator, abrb family B37_04010 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) B37_04011 ENOG4105F8V Hydrolase, tatD family B37_04012 ENOG41069ER domain protein B37_04014 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) B37_04015 ENOG4105XFA sporulation peptidase YabG B37_04016 ENOG4105W42 Veg protein B37_04017 ENOG4105XEW small acid-soluble spore protein B37_04019 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) B37_04020 ENOG4105DFT pur operon repressor B37_04021 ENOG4105KME endoribonuclease L-psp B37_04022 ENOG4105K4W Could be involved in septation (By similarity) B37_04023 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) B37_04024 ENOG4105C5T Phosphoribosyl pyrophosphate synthase B37_04025 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) B37_04028 ENOG4108JA2 transcriptioN-repair coupling factor B37_04029 ENOG4108M14 stage v sporulation protein t B37_04031 ENOG4108IY2 MazG family B37_04032 ENOG41082I2 s4 domain protein B37_04033 ENOG4105VYY sporulation protein yabp B37_04036 ENOG41060GV RNA binding s1 domain protein B37_04042 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) B37_04043 ENOG4108UGV hypoxanthine phosphoribosyltransferase B37_04044 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) B37_04045 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) B37_04046 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) B37_04047 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase B37_04048 ENOG4105C6T cysteine synthase B37_04049 ENOG4105CRQ synthase (Component I) B37_04050 ENOG4105DDQ anthranilate synthase B37_04051 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 B37_04052 ENOG4105EEI dihydropteroate synthase B37_04053 ENOG4105KRF dihydroneopterin aldolase B37_04054 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase B37_04056 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) B37_04057 ENOG4105CRK lysyL-tRNA synthetase B37_04074 ENOG4108Z0C Uvrb UvrC protein B37_04075 ENOG41066A3 ATP guanido phosphotransferase B37_04077 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) B37_04078 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) B37_04079 ENOG4105CTP PilT protein domain protein B37_04080 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) B37_04081 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) B37_04082 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) B37_04083 ENOG4105D7W serine acetyltransferase B37_04084 ENOG4105C8N cysteinyl-tRNA synthetase B37_04085 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) B37_04086 ENOG4105C2N RNA methyltransferase TrmH family group 3 B37_04087 ENOG4105M0M Tetracycline resistance protein B37_04088 ENOG4105QIV RNA polymerase B37_04089 ENOG410683Z Preprotein translocase SecE subunit B37_04090 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) B37_04091 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) B37_04092 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) B37_04093 ENOG4108VZM 50s ribosomal protein L10 B37_04094 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) B37_04095 ENOG4107Y49 methyltransferase B37_04096 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B37_04097 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B37_04098 ENOG4105XPM ribosomal protein B37_04099 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) B37_04100 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) B37_04101 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) B37_04102 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) B37_04103 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) B37_04104 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) B37_04105 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) B37_04106 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) B37_04107 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity B37_04108 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) B37_04109 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) B37_04110 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) B37_04111 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) B37_04112 ENOG41082SA 50s ribosomal protein l29 B37_04113 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal B37_04114 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) B37_04115 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) B37_04116 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits B37_04117 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) B37_04118 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) B37_04119 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) B37_04120 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) B37_04121 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) B37_04122 ENOG4105VPB 50S ribosomal protein L30 B37_04123 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) B37_04124 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B37_04125 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) B37_04126 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B37_04128 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) B37_04130 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits B37_04131 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) B37_04132 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B37_04133 ENOG4108ZT0 50S ribosomal protein l17 B37_04134 ENOG4108JJB ABC transporter B37_04135 ENOG4108JJB ABC transporter B37_04136 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) B37_04137 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B37_04138 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) B37_04139 ENOG4108UJD 30S ribosomal protein S9 B37_04143 ENOG4105D1F ATP-binding protein B37_04146 ENOG4108NMV polysaccharide deacetylase B37_04153 ENOG4108A04 Beta-lactamase B37_04157 ENOG4105JAB phenazine biosynthesis protein, phzf family B37_04158 ENOG4105EHZ conserved protein UCP016719 B37_04159 ENOG4105D17 glycoside hydrolase, family 3 domain protein B37_04163 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate B37_04164 ENOG4105EWC Purine nucleoside phosphorylase B37_04171 ENOG4105EMN RNA polymerase sigma factor B37_04173 ENOG4105C8B TIGR00159 family B37_04174 ENOG4107U5W ybbr family B37_04175 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) B37_04176 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) B37_04179 ENOG4105DVE abc transporter atp-binding protein B37_04180 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B37_04181 ENOG4105WAB arsR family transcriptional regulator B37_04182 ENOG4108RWP Major Facilitator Superfamily protein B37_04184 ENOG4105BZ1 (ABC) transporter B37_04185 ENOG4107ZXU DSBA oxidoreductase B37_04188 ENOG41075D4 Aminoglycoside 6-adenylyltransferase B37_04194 ENOG4108MRH transcriptional regulatory protein B37_04196 ENOG4105DUM transcriptional regulator, lysR family B37_04198 ENOG4105E5W Transporter B37_04199 ENOG4106DDH Sporulation-specific SASP protein B37_04202 ENOG4105C7Z Conserved Protein B37_04203 ENOG4105FTQ Dna gyrase B37_04204 ENOG4105C7Z Conserved Protein B37_04205 ENOG4105DXI Major Facilitator superfamily B37_04210 ENOG4107I77 yiaA/B two helix domain B37_04215 ENOG410631K Membrane B37_04216 ENOG4106AXJ AraC family transcriptional regulator B37_04220 ENOG4107SCQ Iron-containing alcohol dehydrogenase B37_04221 ENOG4105C8Q Methyl-accepting chemotaxis B37_04222 ENOG4105DFW ABC transporter B37_04225 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid B37_04227 ENOG4108IQI permease B37_04228 ENOG4108J5H Homocysteine s-methyltransferase B37_04230 ENOG4105CI1 PTS System B37_04231 ENOG4107TXC Transcriptional regulator B37_04232 ENOG4108QY0 Membrane B37_04236 ENOG4105CSV Glutaminase B37_04239 ENOG4105KNA -acetyltransferase B37_04241 ENOG4105NA0 Transcriptional regulator B37_04243 ENOG4105DGI Alkaline phosphatase B37_04244 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) B37_04245 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B37_04246 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase B37_04247 ENOG4105C26 Dehydrogenase B37_04248 ENOG4105DJB Major Facilitator Superfamily B37_04249 ENOG4105EQX glucarate dehydratase B37_04250 ENOG41073TP transcriptional regulator B37_04251 ENOG4105CTX dehydratase B37_04252 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B37_04257 ENOG4108R1P B37_04258 ENOG4106K80 B37_04260 ENOG41067TZ transcriptional regulator, MarR family B37_04265 ENOG4107TXC Transcriptional regulator B37_04270 ENOG4106UX7 integral membrane protein B37_04272 ENOG41060AI SEC-C motif B37_04273 ENOG4105DA5 (ABC) transporter B37_04278 ENOG4108KSA LysR family transcriptional regulator B37_04279 ENOG4105MDS 4-oxalocrotonate tautomerase B37_04285 ENOG4108W0I acetyltransferase B37_04287 ENOG4105DPN Oligoendopeptidase f B37_04288 ENOG4107BMA Transglycosylase associated protein B37_04290 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B37_04291 ENOG4105CQB FAD linked oxidase domain protein B37_04292 ENOG4105VZJ PTS System B37_04293 ENOG4105VCP PTS System B37_04294 ENOG4105CK1 PTS System B37_04295 ENOG4105F8D glycoside hydrolase family 4 B37_04296 ENOG4108X79 transcriptional regulator B37_04297 ENOG410901P UPF0249 protein B37_04301 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases B37_04302 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B37_04305 ENOG4105KHC sulfurtransferase B37_04307 ENOG4105DEN Luciferase family B37_04308 ENOG4105Z8B NlpC/P60 family B37_04310 ENOG4105CIG ABC transporter B37_04311 ENOG4108RZE Tetr family transcriptional regulator B37_04315 ENOG4108N0M stress protein B37_04316 ENOG4106FN3 tellurium resistance protein B37_04317 ENOG4106FN3 tellurium resistance protein B37_04318 ENOG4107TS3 membrane protein, TerC B37_04321 ENOG4108TTB tellurium resistance protein B37_04323 ENOG4107QIV Cytochrome c biogenesis protein B37_04325 ENOG4107SWG transcriptional regulator MERR family B37_04332 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) B37_04333 ENOG410756H nucleotidyltransferase B37_04335 ENOG4105C26 Dehydrogenase B37_04336 ENOG4105CK7 Sodium proline symporter B37_04337 ENOG4107YHD transcriptional regulator B37_04339 ENOG4108PJD permease B37_04340 ENOG4105I82 acetyl xylan esterase B37_04344 ENOG4105E5Q amino acid AbC transporter B37_04345 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein B37_04346 ENOG4105NF4 modulator of drug activity B37_04348 ENOG4105CS2 ec 3.2.1.21 B37_04351 ENOG4107WDG serine threonine protein kinase B37_04352 ENOG4105C8Q Methyl-accepting chemotaxis B37_04353 ENOG4105C8Q Methyl-accepting chemotaxis B37_04359 ENOG4105F38 ABC transporter, permease B37_04361 ENOG4105CEY Amp-dependent synthetase and ligase B37_04365 ENOG4105SX7 Transporter B37_04367 ENOG4105W8Z 4'-phosphopantetheinyl transferase B37_04368 ENOG4108SA1 esterase B37_04372 ENOG4105CJ1 ABC, transporter B37_04378 ENOG4105CDA abc transporter atp-binding protein B37_04379 ENOG4105DRP amino acid AbC transporter B37_04381 ENOG4108JUB Transcriptional regulator B37_04382 ENOG4105C8Y Acetylornithine aminotransferase B37_04383 ENOG4108IQI permease B37_04384 ENOG41066UZ arginase EC 3.5.3.1 B37_04385 ENOG4106P55 Transcriptional regulator B37_04386 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase B37_04387 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) B37_04388 ENOG41069ZX B37_04389 ENOG41069ZX B37_04397 ENOG4107EV6 Inherit from COG: YD repeat protein B37_04401 ENOG4105C2F Histidine kinase B37_04402 ENOG4105EQD regulatoR B37_04403 ENOG4105DFW ABC transporter B37_04405 ENOG4108HWW ABC transporter B37_04406 ENOG4105DCM major facilitator superfamily B37_04407 ENOG410645S MarR family Transcriptional regulator B37_04408 ENOG4105C4C beta-galactosidase B37_04409 ENOG4107T32 3-phytase (EC 3.1.3.8) B37_04410 ENOG4105DUX Transporter B37_04413 ENOG4105E1K spore germination protein B37_04416 ENOG4107TXC Transcriptional regulator B37_04418 ENOG4107WD8 ABC transporter, permease B37_04419 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B37_04420 ENOG4105BZU Histidine kinase B37_04421 ENOG4105C8Q Methyl-accepting chemotaxis B37_04422 ENOG4105C8Q Methyl-accepting chemotaxis B37_04423 ENOG4105CFH Aspartokinase B37_04424 ENOG4105DHS permease protein B37_04425 ENOG4105CM4 permease protein B37_04426 ENOG4108IPW abc transporter atp-binding protein B37_04429 ENOG4105R8C Transcriptional regulator B37_04431 ENOG4108DBC nitroreductase B37_04432 ENOG41067V3 Antibiotic biosynthesis monooxygenase B37_04433 ENOG4105YVS arsR family transcriptional regulator B37_04435 ENOG4108JPW Aminotransferase B37_04436 ENOG4107QTZ amino acid B37_04437 ENOG4105C26 Dehydrogenase B37_04438 ENOG4108RNG Permease of the drug metabolite transporter B37_04440 ENOG4105KTB nuclear export factor GLE1 B37_04441 ENOG4108T5E Copper resistance protein B37_04442 ENOG4108ZYE Transcriptional regulator B37_04444 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) B37_04445 ENOG4108IFG nitrite reductase, (NAD(P)H) B37_04446 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit B37_04447 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B37_04448 ENOG4105DRR Transcriptional regulator, GntR family B37_04449 ENOG4105C8P )-transporter B37_04451 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia B37_04455 ENOG4108IUS Transketolase B37_04457 ENOG4105E7W lamb ycsf family protein B37_04458 ENOG4105C5A transporter B37_04459 ENOG4105CFM UPF0317 protein B37_04460 ENOG4105P4J Allophanate hydrolase, subunit 1 B37_04462 ENOG4107258 Transcriptional regulator B37_04463 ENOG4105XJB lipolytic protein G-D-S-L family B37_04466 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase B37_04467 ENOG4105ETD TRANSCRIPTIONal B37_04468 ENOG4105CYX Short-chain dehydrogenase reductase Sdr B37_04471 ENOG410606W general stress protein B37_04473 ENOG4108RCF TRANSCRIPTIONal B37_04474 ENOG4105VCH membrane B37_04477 ENOG4105C9U ATP-dependent DNA helicase RecQ B37_04478 ENOG4105C0X amino acid B37_04479 ENOG4105C0X amino acid B37_04481 ENOG4108M1A Chitin-binding protein B37_04483 ENOG4105DQ6 Transposase B37_04486 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) B37_04487 ENOG4107BMA Transglycosylase associated protein B37_04488 ENOG4108IJ0 Aspartate ammonia-lyase B37_04489 ENOG41087PP glycosyltransferase MGT family B37_04490 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) B37_04491 ENOG4105EU9 B37_04493 ENOG41082W1 Cupin 2, conserved barrel domain protein B37_04494 ENOG4105QVS general stress protein B37_04495 ENOG4106F5Q Membrane B37_04496 ENOG4105CK2 sodium dicarboxylate symporter B37_04497 ENOG4105CJ1 ABC, transporter B37_04500 ENOG4105FDT acyl-CoA dehydrogenase B37_04503 ENOG4105SZ6 Thioredoxin B37_04504 ENOG4105CPF Cell wall formation (By similarity) B37_04505 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) B37_04507 ENOG4105C1J atp-dependent rna helicase B37_04508 ENOG410905X membrane-flanked domain protein B37_04509 ENOG4105CKV Membrane B37_04511 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein B37_04512 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B37_04514 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) B37_04515 ENOG4107MMM Anti-sigma-factor antagonist B37_04516 ENOG4105FUA antagonist B37_04517 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase B37_04518 ENOG4107SGM protein serine threonine phosphatase B37_04522 ENOG41064BQ Phosphatase B37_04524 ENOG4105ST3 Transcriptional regulator B37_04525 ENOG4105EYF MMPL domain protein B37_04535 ENOG4105VZ8 Transcriptional regulator B37_04536 ENOG4105ECK Fatty Acid Desaturase B37_04537 ENOG4105VEQ Cold shock protein B37_04538 ENOG4105CPQ Dehydrogenase B37_04541 ENOG4108U05 Transcriptional regulator B37_04542 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 B37_04545 ENOG4105KVH Transcriptional regulator B37_04551 ENOG4107XCH Cyclase family B37_04552 ENOG4105C85 amino acid B37_04555 ENOG4105JVQ RNA Polymerase B37_04556 ENOG4108P49 AntiSigma factor B37_04557 ENOG4105EXC Acyl-transferase B37_04558 ENOG4105C2C drug resistance transporter, Bcr CflA B37_04560 ENOG4108NEV two component transcriptional regulator, LytTR family B37_04562 ENOG4108Z6X (sortase) family B37_04563 ENOG4107QNK )-transporter B37_04571 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) B37_04572 ENOG4105K8N protein family UPF0079, ATPase B37_04573 ENOG41072GX Peptidase M22 Glycoprotease B37_04574 ENOG410801F ribosomal-protein-alanine acetyltransferase B37_04575 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B37_04576 ENOG4105C5H ABC transporter B37_04578 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) B37_04579 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) B37_04580 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B37_04582 ENOG4108TYN CAAX amino terminal protease family protein B37_04583 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) B37_04584 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) B37_04585 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B37_04586 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B37_04615 ENOG4105CAR Terminase, large subunit