locus-tag	class	description
B37_00010	COG1705	Flagellar rod assembly protein muramidase FlgJ
B37_00019	COG5444	nuclease activity
B37_00027	COG2720	vancomycin resistance protein
B37_00030	COG2135	peptidase activity
B37_00031	COG1309	transcriptional regulator
B37_00032	COG3848	Pyruvate phosphate dikinase
B37_00032	COG0574	Belongs to the PEP-utilizing enzyme family
B37_00034	COG3189	MarR family transcriptional regulator
B37_00035	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
B37_00036	COG2272	Belongs to the type-B carboxylesterase lipase family
B37_00037	COG2814	Major facilitator Superfamily
B37_00038	COG1842	Phage shock protein A
B37_00039	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B37_00040	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B37_00041	COG4260	virion core protein, lumpy skin disease virus
B37_00043	COG1378	Sugar-specific transcriptional regulator TrmB
B37_00044	COG1280	lysine exporter protein (LysE YggA)
B37_00045	COG3339	Conserved Protein
B37_00046	COG0772	Belongs to the SEDS family
B37_00047	COG0772	Belongs to the SEDS family
B37_00051	COG0726	polysaccharide deacetylase
B37_00053	COG1609	Transcriptional regulator
B37_00054	COG0366	Alpha amylase catalytic
B37_00055	COG2182	Extracellular solute-binding protein
B37_00056	COG1175	transmembrane transport
B37_00057	COG3833	ABC-type maltose transport systems, permease component
B37_00058	COG5521	maltodextrose utilization protein MalA
B37_00059	COG1554	hydrolase, family 65, central catalytic
B37_00060	COG0366	Alpha amylase catalytic
B37_00061	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B37_00062	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B37_00063	COG1846	Transcriptional regulator
B37_00066	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B37_00067	COG0823	Involved in the tonB-independent uptake of proteins
B37_00073	COG0702	epimerase
B37_00075	COG2132	Multicopper oxidase
B37_00078	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B37_00079	COG0714	Associated with various cellular activities
B37_00080	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B37_00081	COG1305	Transglutaminase-like
B37_00082	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B37_00082	COG0519	Catalyzes the synthesis of GMP from XMP
B37_00083	COG2252	PERMEase
B37_00086	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B37_00088	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B37_00089	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B37_00090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B37_00091	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B37_00092	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B37_00093	COG0047	phosphoribosylformylglycinamidine synthase activity
B37_00094	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B37_00095	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B37_00096	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B37_00097	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B37_00098	COG0138	bifunctional purine biosynthesis protein purh
B37_00099	COG0151	Belongs to the GarS family
B37_00101	COG2124	cytochrome p450
B37_00106	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B37_00107	COG1470	cell adhesion involved in biofilm formation
B37_00108	COG4496	protein, YerC YecD
B37_00109	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B37_00110	COG0210	DNA helicase
B37_00111	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B37_00112	COG4851	CamS sex pheromone cAM373 precursor
B37_00113	COG2188	Transcriptional regulator
B37_00117	COG1735	metal-dependent hydrolase with the TIM-barrel fold
B37_00118	COG0626	cystathionine gamma-synthase activity
B37_00119	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B37_00120	COG3457	Alanine racemase
B37_00121	COG0363	glucosamine-6-phosphate deaminase activity
B37_00122	COG1285	pathogenesis
B37_00123	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_00124	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B37_00125	COG0154	amidase activity
B37_00126	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B37_00129	COG4124	Belongs to the glycosyl hydrolase 26 family
B37_00130	COG1309	transcriptional regulator
B37_00131	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B37_00133	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B37_00135	COG1597	lipid kinase activity
B37_00136	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B37_00137	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B37_00143	COG3645	SOS response
B37_00145	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B37_00151	COG2801	Transposase and inactivated derivatives
B37_00152	COG1263	PTS System
B37_00152	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_00152	COG2190	(PTS) system
B37_00153	COG2723	6-phospho-beta-galactosidase activity
B37_00154	COG3711	transcriptional antiterminator
B37_00155	COG0457	Tetratricopeptide repeat
B37_00158	COG0217	transcriptional regulatory protein
B37_00161	COG1012	belongs to the aldehyde dehydrogenase family
B37_00162	COG0840	transmembrane signaling receptor activity
B37_00163	COG0471	metal ion transport
B37_00164	COG0488	(ABC) transporter
B37_00165	COG1469	GTP cyclohydrolase I activity
B37_00168	COG0523	cobalamin synthesis protein
B37_00169	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B37_00170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B37_00171	COG0156	8-amino-7-oxononanoate synthase activity
B37_00172	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B37_00173	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B37_00174	COG2124	cytochrome p450
B37_00176	COG0789	Transcriptional regulator
B37_00177	COG2814	Major facilitator Superfamily
B37_00178	COG0488	(ABC) transporter
B37_00179	COG0513	Belongs to the DEAD box helicase family
B37_00180	COG2130	NADP-dependent
B37_00182	COG0471	metal ion transport
B37_00185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_00187	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B37_00188	COG5658	integral membrane protein
B37_00189	COG0640	Transcriptional regulator
B37_00190	COG1254	Belongs to the acylphosphatase family
B37_00191	COG2258	MOSC domain
B37_00194	COG0024	Methionine aminopeptidase
B37_00195	COG1368	sulfuric ester hydrolase activity
B37_00197	COG1115	amino acid carrier protein
B37_00198	COG1263	PTS System
B37_00198	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_00199	COG0366	Alpha amylase catalytic
B37_00200	COG2188	Transcriptional regulator
B37_00204	COG2801	Transposase and inactivated derivatives
B37_00206	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B37_00207	COG1045	serine acetyltransferase
B37_00208	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B37_00210	COG1215	transferase activity, transferring glycosyl groups
B37_00211	COG0457	Tetratricopeptide repeat
B37_00211	COG0463	Glycosyl transferase, family 2
B37_00213	COG0673	inositol 2-dehydrogenase activity
B37_00216	COG1733	regulation of RNA biosynthetic process
B37_00217	COG0778	Nitroreductase
B37_00218	COG0737	Belongs to the 5'-nucleotidase family
B37_00219	COG0693	protein deglycase activity
B37_00220	COG4840	Belongs to the UPF0435 family
B37_00221	COG1115	amino acid carrier protein
B37_00222	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B37_00223	COG4980	gas vesicle protein
B37_00224	COG1295	ribonuclease BN
B37_00226	COG0477	Major facilitator Superfamily
B37_00228	COG0387	Pfam Sodium calcium exchanger
B37_00230	COG0535	radical SAM domain protein
B37_00232	COG0726	polysaccharide deacetylase
B37_00233	COG0371	Dehydrogenase
B37_00235	COG0598	Magnesium transport protein CorA
B37_00236	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B37_00237	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B37_00238	COG4637	Psort location Cytoplasmic, score
B37_00243	COG1819	glycosyl
B37_00245	COG0477	Major facilitator Superfamily
B37_00246	COG1263	PTS System
B37_00246	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_00247	COG3711	transcriptional antiterminator
B37_00248	COG0288	reversible hydration of carbon dioxide
B37_00249	COG3002	Belongs to the UPF0753 family
B37_00250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B37_00251	COG5609	conserved protein (DUF2294)
B37_00253	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B37_00254	COG0022	dehydrogenase e1 component
B37_00255	COG0508	dehydrogenase complex catalyzes the overall conversion of
B37_00256	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B37_00257	COG3284	Transcriptional regulator
B37_00258	COG1742	UPF0060 membrane protein
B37_00259	COG1486	melibiose metabolic process
B37_00260	COG1737	Transcriptional regulator
B37_00261	COG1263	PTS System
B37_00261	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_00264	COG1733	regulation of RNA biosynthetic process
B37_00265	COG2259	Doxx family
B37_00266	COG2514	catechol 2,3-dioxygenase activity
B37_00268	COG3507	Belongs to the glycosyl hydrolase 43 family
B37_00269	COG2207	Transcriptional regulator
B37_00269	COG1917	Cupin 2, conserved barrel domain protein
B37_00270	COG1653	transport
B37_00271	COG2249	NAD(P)H dehydrogenase (quinone) activity
B37_00272	COG1051	belongs to the nudix hydrolase family
B37_00274	COG0392	lysyltransferase activity
B37_00274	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B37_00276	COG0384	phenazine biosynthesis protein PhzF
B37_00277	COG0778	Nitroreductase
B37_00281	COG1090	epimerase
B37_00282	COG2137	regulation of response to DNA damage stimulus
B37_00287	COG0463	Glycosyl transferase, family 2
B37_00289	COG4485	Bacterial membrane protein, YfhO
B37_00290	COG1988	membrane-bound metal-dependent
B37_00291	COG1194	a g-specific adenine glycosylase
B37_00293	COG1028	Short-chain dehydrogenase reductase Sdr
B37_00296	COG3557	Belongs to the UPF0374 family
B37_00297	COG1132	(ABC) transporter
B37_00298	COG0444	Belongs to the ABC transporter superfamily
B37_00299	COG4608	Belongs to the ABC transporter superfamily
B37_00300	COG0747	negative chemotaxis
B37_00303	COG4129	membrane
B37_00304	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B37_00305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B37_00306	COG0735	belongs to the Fur family
B37_00327	COG4974	Belongs to the 'phage' integrase family
B37_00355	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B37_00355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B37_00358	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B37_00364	COG1780	Probably involved in ribonucleotide reductase function
B37_00365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_00367	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_00368	COG0756	dUTP diphosphatase activity
B37_00371	COG3584	3D domain protein
B37_00393	COG0740	serine-type endopeptidase activity
B37_00403	COG5280	Phage tail tape measure protein TP901
B37_00403	COG3953	SLT domain
B37_00411	COG1388	LysM domain
B37_00411	COG3409	Peptidoglycan-binding domain 1 protein
B37_00411	COG5632	N-Acetylmuramoyl-L-alanine amidase
B37_00415	COG0438	transferase activity, transferring glycosyl groups
B37_00420	COG0457	Tetratricopeptide repeat
B37_00426	COG5444	nuclease activity
B37_00430	COG5444	nuclease activity
B37_00431	COG0457	Tetratricopeptide repeat
B37_00433	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B37_00434	COG0710	3-dehydroquinate dehydratase activity
B37_00435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B37_00436	COG1116	anion transmembrane transporter activity
B37_00437	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B37_00438	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B37_00439	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B37_00441	COG1476	TRANSCRIPTIONal
B37_00443	COG1131	(ABC) transporter
B37_00447	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B37_00449	COG3382	B3 4 domain protein
B37_00450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B37_00452	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B37_00453	COG0789	Transcriptional regulator
B37_00454	COG1664	Polymer-forming cytoskeletal
B37_00456	COG2766	serine protein kinase
B37_00457	COG2718	Belongs to the UPF0229 family
B37_00460	COG4974	Belongs to the 'phage' integrase family
B37_00479	COG0457	Tetratricopeptide repeat
B37_00481	COG5444	nuclease activity
B37_00485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B37_00491	COG4195	phage-related replication protein
B37_00492	COG5434	Belongs to the glycosyl hydrolase 28 family
B37_00492	COG3420	alginic acid biosynthetic process
B37_00496	COG2131	deaminase
B37_00497	COG2002	toxin-antitoxin pair type II binding
B37_00526	COG0739	heme binding
B37_00526	COG0741	lytic transglycosylase activity
B37_00526	COG1196	nuclear chromosome segregation
B37_00533	COG5632	N-Acetylmuramoyl-L-alanine amidase
B37_00539	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B37_00541	COG2176	DNA-directed DNA polymerase activity
B37_00546	COG0194	GDP metabolic process
B37_00552	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B37_00558	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_00559	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_00565	COG1566	PFAM secretion protein HlyD family protein
B37_00566	COG2814	Major facilitator Superfamily
B37_00567	COG0655	NAD(P)H dehydrogenase (quinone) activity
B37_00569	COG1131	(ABC) transporter
B37_00570	COG1131	(ABC) transporter
B37_00571	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B37_00572	COG2801	Transposase and inactivated derivatives
B37_00574	COG1278	Cold shock
B37_00575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B37_00576	COG2011	ABC-type metal ion transport system permease component
B37_00577	COG1464	Belongs to the NlpA lipoprotein family
B37_00578	COG1823	symporter activity
B37_00583	COG5577	PFAM Coat F domain
B37_00584	COG5002	protein histidine kinase activity
B37_00585	COG4085	toxin activity
B37_00585	COG1525	nuclease
B37_00585	COG0737	Belongs to the 5'-nucleotidase family
B37_00586	COG3764	Sortase (surface protein transpeptidase)
B37_00587	COG0564	pseudouridine synthase activity
B37_00589	COG0517	IMP dehydrogenase activity
B37_00590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B37_00591	COG3153	acetyltransferase
B37_00591	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B37_00593	COG0488	(ABC) transporter
B37_00594	COG2116	formate transmembrane transporter activity
B37_00595	COG0679	Auxin Efflux Carrier
B37_00596	COG0604	alcohol dehydrogenase
B37_00597	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B37_00598	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B37_00599	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B37_00600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B37_00601	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B37_00604	COG2203	Gaf domain
B37_00604	COG4585	Histidine kinase
B37_00605	COG2197	response regulator
B37_00606	COG0431	NADPH-dependent FMN reductase
B37_00609	COG1959	2 iron, 2 sulfur cluster binding
B37_00610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B37_00610	COG1017	nitric oxide dioxygenase activity
B37_00611	COG2719	SpoVR family
B37_00612	COG1388	LysM domain
B37_00612	COG0791	NLP P60 protein
B37_00613	COG0583	DNA-binding transcription factor activity
B37_00614	COG0372	Belongs to the citrate synthase family
B37_00615	COG2133	pyrroloquinoline quinone binding
B37_00616	COG1028	Short-chain dehydrogenase reductase Sdr
B37_00617	COG0733	neurotransmitter:sodium symporter activity
B37_00619	COG3708	Transcriptional regulator
B37_00619	COG2207	Transcriptional regulator
B37_00620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B37_00624	COG1595	DNA-templated transcription, initiation
B37_00625	COG0662	Cupin 2, conserved barrel domain protein
B37_00627	COG0204	Acyl-transferase
B37_00629	COG3152	Membrane
B37_00631	COG1309	transcriptional regulator
B37_00632	COG1253	flavin adenine dinucleotide binding
B37_00633	COG0789	Transcriptional regulator
B37_00635	COG1253	flavin adenine dinucleotide binding
B37_00639	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B37_00640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B37_00641	COG0584	glycerophosphoryl diester phosphodiesterase
B37_00643	COG0668	transmembrane transport
B37_00644	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B37_00647	COG0726	polysaccharide deacetylase
B37_00649	COG1757	Na H antiporter
B37_00650	COG2017	converts alpha-aldose to the beta-anomer
B37_00654	COG0589	response to stress
B37_00655	COG1132	(ABC) transporter
B37_00656	COG1132	(ABC) transporter
B37_00657	COG0702	epimerase
B37_00661	COG3842	ATPase activity
B37_00662	COG2508	Transcriptional regulator
B37_00664	COG0189	ligase activity
B37_00665	COG0189	ligase activity
B37_00666	COG4399	Belongs to the UPF0754 family
B37_00667	COG3679	Belongs to the UPF0342 family
B37_00668	COG0561	phosphatase activity
B37_00669	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B37_00670	COG0475	glutathione-regulated potassium exporter activity
B37_00671	COG0490	domain, Protein
B37_00673	COG1024	Enoyl-CoA hydratase
B37_00674	COG0457	Tetratricopeptide repeat
B37_00678	COG4152	abc transporter atp-binding protein
B37_00679	COG1668	transmembrane transport
B37_00680	COG0420	3'-5' exonuclease activity
B37_00681	COG4717	serine-type aminopeptidase activity
B37_00682	COG3481	metal-dependent phosphohydrolase, HD sub domain
B37_00684	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B37_00688	COG1846	Transcriptional regulator
B37_00689	COG4980	gas vesicle protein
B37_00692	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B37_00693	COG0537	adenosine 5'-monophosphoramidase activity
B37_00694	COG1131	(ABC) transporter
B37_00695	COG4473	ABC transporter
B37_00697	COG1473	amidohydrolase
B37_00698	COG3069	C4-dicarboxylate transmembrane transporter activity
B37_00699	COG2329	Antibiotic biosynthesis monooxygenase
B37_00700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B37_00701	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B37_00704	COG1309	transcriptional regulator
B37_00705	COG1511	domain protein
B37_00706	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B37_00707	COG1363	Peptidase, m42
B37_00709	COG1301	dicarboxylic acid transport
B37_00711	COG1234	tRNA 3'-trailer cleavage
B37_00712	COG0095	Lipoate-protein ligase
B37_00713	COG0318	PFAM AMP-dependent synthetase and ligase
B37_00715	COG1396	sequence-specific DNA binding
B37_00718	COG0501	Belongs to the peptidase M48B family
B37_00720	COG0697	spore germination
B37_00721	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B37_00722	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_00723	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_00724	COG0406	alpha-ribazole phosphatase activity
B37_00725	COG0840	transmembrane signaling receptor activity
B37_00726	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B37_00726	COG0723	plastoquinol--plastocyanin reductase activity
B37_00727	COG1028	Short-chain dehydrogenase reductase Sdr
B37_00729	COG4903	ComK protein
B37_00731	COG0398	Pfam SNARE associated Golgi protein
B37_00732	COG0681	Belongs to the peptidase S26 family
B37_00733	COG1404	Belongs to the peptidase S8 family
B37_00735	COG2508	Transcriptional regulator
B37_00737	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B37_00738	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B37_00739	COG3257	ureidoglycine aminohydrolase activity
B37_00740	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B37_00741	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B37_00742	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B37_00743	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B37_00744	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B37_00746	COG0549	Belongs to the carbamate kinase family
B37_00747	COG2814	Major facilitator Superfamily
B37_00749	COG0457	Tetratricopeptide repeat
B37_00757	COG1486	melibiose metabolic process
B37_00758	COG3180	Ammonia monooxygenase
B37_00761	COG3546	catalase activity
B37_00762	COG0318	PFAM AMP-dependent synthetase and ligase
B37_00763	COG2814	Major facilitator Superfamily
B37_00763	COG0477	Major facilitator Superfamily
B37_00765	COG5002	protein histidine kinase activity
B37_00766	COG0745	RESPONSE REGULATOR receiver
B37_00767	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
B37_00768	COG0725	ABC transporter, periplasmic molybdate-binding protein
B37_00769	COG4149	molybdate abc transporter
B37_00770	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B37_00771	COG1074	ATP-dependent DNA helicase activity
B37_00772	COG0420	3'-5' exonuclease activity
B37_00773	COG0419	ATPase involved in DNA repair
B37_00782	COG5337	Spore coat protein CotH
B37_00784	COG0179	Fumarylacetoacetate (FAA) hydrolase
B37_00790	COG0367	asparagine synthase
B37_00791	COG0004	ammonium transporteR
B37_00792	COG0004	ammonium transporteR
B37_00793	COG0347	Belongs to the P(II) protein family
B37_00794	COG0534	Mate efflux family protein
B37_00795	COG2207	Transcriptional regulator
B37_00795	COG1917	Cupin 2, conserved barrel domain protein
B37_00797	COG1609	Transcriptional regulator
B37_00798	COG0673	inositol 2-dehydrogenase activity
B37_00799	COG0673	inositol 2-dehydrogenase activity
B37_00800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B37_00802	COG0076	glutamate decarboxylase activity
B37_00807	COG2153	protein acetylation
B37_00808	COG1028	Short-chain dehydrogenase reductase Sdr
B37_00809	COG2378	regulation of single-species biofilm formation
B37_00810	COG0646	methionine synthase
B37_00810	COG1410	methionine synthase
B37_00811	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B37_00811	COG0646	methionine synthase
B37_00812	COG1666	GTP binding
B37_00813	COG2996	Protein conserved in bacteria
B37_00816	COG1307	EDD domain protein, DegV family
B37_00817	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_00819	COG0516	GMP reductase activity
B37_00821	COG0561	phosphatase activity
B37_00822	COG1073	alpha beta
B37_00823	COG2151	metal-sulfur cluster biosynthetic enzyme
B37_00824	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B37_00825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B37_00826	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B37_00827	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B37_00828	COG0505	Belongs to the CarA family
B37_00829	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B37_00830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B37_00831	COG1968	undecaprenyl-diphosphatase activity
B37_00834	COG2267	carboxylic ester hydrolase activity
B37_00836	COG1744	ABC transporter substrate-binding protein PnrA-like
B37_00839	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B37_00840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B37_00841	COG5504	Zn-dependent protease
B37_00842	COG0444	Belongs to the ABC transporter superfamily
B37_00843	COG4608	Belongs to the ABC transporter superfamily
B37_00845	COG0601	transmembrane transport
B37_00846	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B37_00851	COG0180	Tryptophanyl-tRNA synthetase
B37_00852	COG4166	transmembrane transport
B37_00853	COG0601	transmembrane transport
B37_00854	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B37_00855	COG0444	Belongs to the ABC transporter superfamily
B37_00856	COG4608	Belongs to the ABC transporter superfamily
B37_00857	COG0456	acetyltransferase
B37_00858	COG1393	Belongs to the ArsC family
B37_00859	COG0861	Integral membrane protein TerC family
B37_00860	COG4862	establishment of competence for transformation
B37_00864	COG4565	transcriptional regulatory protein
B37_00865	COG3290	protein histidine kinase activity
B37_00866	COG4469	Competence protein
B37_00867	COG1164	Oligoendopeptidase f
B37_00870	COG2346	COG2346, Truncated hemoglobins
B37_00871	COG0741	lytic transglycosylase activity
B37_00872	COG4116	CYTH
B37_00874	COG2357	RelA SpoT domain protein
B37_00875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B37_00876	COG0564	pseudouridine synthase activity
B37_00877	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B37_00878	COG0569	domain protein
B37_00878	COG0475	glutathione-regulated potassium exporter activity
B37_00879	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B37_00880	COG0352	thiamine-phosphate diphosphorylase activity
B37_00882	COG2104	thiamine diphosphate biosynthetic process
B37_00883	COG2022	thiamine diphosphate biosynthetic process
B37_00884	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B37_00885	COG0351	phosphomethylpyrimidine kinase
B37_00886	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B37_00897	COG0210	DNA helicase
B37_00899	COG0586	Pfam SNARE associated Golgi protein
B37_00900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B37_00901	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B37_00902	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B37_00903	COG2246	polysaccharide biosynthetic process
B37_00904	COG2153	protein acetylation
B37_00905	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B37_00906	COG2382	esterase
B37_00909	COG0626	cystathionine gamma-synthase activity
B37_00910	COG0626	cystathionine gamma-synthase activity
B37_00911	COG5505	Protein of unknown function (DUF819)
B37_00914	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B37_00915	COG3507	Belongs to the glycosyl hydrolase 43 family
B37_00918	COG0110	maltose O-acetyltransferase activity
B37_00920	COG0583	DNA-binding transcription factor activity
B37_00921	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B37_00922	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B37_00923	COG0583	DNA-binding transcription factor activity
B37_00924	COG0697	spore germination
B37_00925	COG0346	lactoylglutathione lyase activity
B37_00927	COG1388	LysM domain
B37_00927	COG3584	3D domain protein
B37_00928	COG2814	Major facilitator Superfamily
B37_00929	COG1309	transcriptional regulator
B37_00932	COG5444	nuclease activity
B37_00933	COG5444	nuclease activity
B37_00934	COG4195	phage-related replication protein
B37_00935	COG2856	Zn peptidase
B37_00936	COG1396	sequence-specific DNA binding
B37_00939	COG1522	sequence-specific DNA binding
B37_00940	COG1484	DNA-dependent DNA replication
B37_00944	COG1595	DNA-templated transcription, initiation
B37_00945	COG3728	DNA packaging
B37_00945	COG5484	DNA packaging
B37_00946	COG1783	phage Terminase large subunit
B37_00947	COG5518	Phage portal protein
B37_00948	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B37_00949	COG4653	Phage capsid family
B37_00958	COG3953	SLT domain
B37_00958	COG5412	phage tail tape measure protein
B37_00959	COG1652	LysM domain
B37_00960	COG4193	domain, Protein
B37_00962	COG3628	GPW Gp25 family protein
B37_00963	COG3299	homolog of phage Mu protein gp47
B37_00964	COG3778	Protein conserved in bacteria
B37_00972	COG1802	Transcriptional regulator
B37_00973	COG1063	alcohol dehydrogenase
B37_00974	COG1312	Catalyzes the dehydration of D-mannonate
B37_00975	COG1028	Short-chain dehydrogenase reductase Sdr
B37_00976	COG1063	alcohol dehydrogenase
B37_00977	COG2271	Major facilitator Superfamily
B37_00980	COG0306	phosphate transporter
B37_00981	COG1392	Phosphate transport regulator
B37_00982	COG0405	Gamma-glutamyltransferase
B37_00983	COG5578	integral membrane protein
B37_00984	COG5578	integral membrane protein
B37_00985	COG2972	Histidine kinase
B37_00986	COG4753	response regulator
B37_00986	COG2207	Transcriptional regulator
B37_00987	COG1653	transport
B37_00988	COG1175	transmembrane transport
B37_00989	COG0395	ABC-type sugar transport system, permease component
B37_00990	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B37_00991	COG2207	Transcriptional regulator
B37_00992	COG2755	lipolytic protein G-D-S-L family
B37_00994	COG5578	integral membrane protein
B37_00995	COG3401	FG-GAP repeat protein
B37_00997	COG2755	lipolytic protein G-D-S-L family
B37_00998	COG3401	FG-GAP repeat protein
B37_00999	COG0667	Aldo Keto reductase
B37_01000	COG2755	lipolytic protein G-D-S-L family
B37_01001	COG1874	Beta-galactosidase
B37_01003	COG1653	transport
B37_01004	COG4209	transmembrane transport
B37_01005	COG0395	ABC-type sugar transport system, permease component
B37_01006	COG0531	amino acid
B37_01007	COG0346	lactoylglutathione lyase activity
B37_01009	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B37_01010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B37_01011	COG2362	D-Aminopeptidase
B37_01012	COG0601	transmembrane transport
B37_01013	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B37_01014	COG0444	Belongs to the ABC transporter superfamily
B37_01015	COG4166	transmembrane transport
B37_01016	COG1619	proteins homologs of microcin C7 resistance protein MccF
B37_01017	COG4948	Mandelate Racemase Muconate Lactonizing
B37_01018	COG0791	NLP P60 protein
B37_01019	COG4608	Belongs to the ABC transporter superfamily
B37_01020	COG1834	amidinotransferase
B37_01021	COG1607	acyl-coa hydrolase
B37_01022	COG2323	membrane
B37_01023	COG3866	Pectate lyase
B37_01028	COG2318	DinB family
B37_01029	COG2076	Multidrug Resistance protein
B37_01030	COG2076	Multidrug Resistance protein
B37_01031	COG0788	formyltetrahydrofolate deformylase activity
B37_01032	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B37_01033	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B37_01034	COG1764	response to oxidative stress
B37_01036	COG1846	Transcriptional regulator
B37_01037	COG1764	response to oxidative stress
B37_01039	COG0590	tRNA wobble adenosine to inosine editing
B37_01040	COG0406	alpha-ribazole phosphatase activity
B37_01043	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B37_01044	COG1404	Belongs to the peptidase S8 family
B37_01046	COG2239	Acts as a magnesium transporter
B37_01048	COG0789	Transcriptional regulator
B37_01052	COG1846	Transcriptional regulator
B37_01053	COG3285	dna ligase
B37_01053	COG1793	dna ligase
B37_01054	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B37_01055	COG3300	MHYT domain
B37_01055	COG5001	Diguanylate cyclase
B37_01056	COG0586	Pfam SNARE associated Golgi protein
B37_01057	COG0861	Integral membrane protein TerC family
B37_01058	COG1191	sigma factor activity
B37_01062	COG0501	Belongs to the peptidase M48B family
B37_01063	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B37_01064	COG0768	penicillin binding
B37_01067	COG3594	Acyltransferase
B37_01068	COG5002	protein histidine kinase activity
B37_01069	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B37_01071	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B37_01072	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B37_01073	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B37_01074	COG0436	Aminotransferase
B37_01075	COG1850	ribulose-bisphosphate carboxylase activity
B37_01076	COG0235	Class ii aldolase
B37_01076	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
B37_01077	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B37_01078	COG0346	lactoylglutathione lyase activity
B37_01079	COG3339	Conserved Protein
B37_01081	COG3852	Histidine kinase
B37_01082	COG1846	Transcriptional regulator
B37_01083	COG1360	Flagellar Motor Protein
B37_01084	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B37_01085	COG0542	response to heat
B37_01086	COG3949	Membrane
B37_01087	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B37_01088	COG0720	synthase
B37_01089	COG0602	queuosine metabolic process
B37_01090	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B37_01093	COG0457	Tetratricopeptide repeat
B37_01094	COG0457	Tetratricopeptide repeat
B37_01095	COG3739	integral membrane protein
B37_01096	COG3655	Transcriptional regulator
B37_01101	COG2801	Transposase and inactivated derivatives
B37_01105	COG4873	Protein conserved in bacteria
B37_01107	COG3773	Cell wall hydrolase
B37_01108	COG2244	polysaccharide biosynthetic process
B37_01109	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_01110	COG2217	Heavy metal translocating P-type atpase
B37_01111	COG0006	proline dipeptidase activity
B37_01114	COG1609	Transcriptional regulator
B37_01115	COG3711	transcriptional antiterminator
B37_01116	COG2190	(PTS) system
B37_01116	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_01116	COG1263	PTS System
B37_01117	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_01118	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B37_01120	COG1533	DNA photolyase activity
B37_01121	COG0456	acetyltransferase
B37_01122	COG0840	transmembrane signaling receptor activity
B37_01123	COG1028	Short-chain dehydrogenase reductase Sdr
B37_01124	COG2084	Dehydrogenase
B37_01125	COG2340	Cysteine-rich secretory protein family
B37_01126	COG0768	penicillin binding
B37_01127	COG4191	Histidine kinase
B37_01128	COG0436	Aminotransferase
B37_01130	COG1714	RDD family
B37_01132	COG0784	Response regulator, receiver
B37_01132	COG0835	chemotaxis
B37_01134	COG2814	Major facilitator Superfamily
B37_01135	COG1376	ErfK ybiS ycfS ynhG family protein
B37_01136	COG1408	metallophosphoesterase
B37_01137	COG1028	Short-chain dehydrogenase reductase Sdr
B37_01138	COG2200	EAL domain
B37_01140	COG4703	Protein of unknown function (DUF1797)
B37_01142	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B37_01144	COG0517	IMP dehydrogenase activity
B37_01145	COG0583	DNA-binding transcription factor activity
B37_01146	COG0716	FMN binding
B37_01148	COG0716	FMN binding
B37_01149	COG2171	N-acyltransferase activity
B37_01150	COG1473	amidohydrolase
B37_01152	COG0450	alkyl hydroperoxide reductase
B37_01153	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_01156	COG0746	molybdenum cofactor guanylyltransferase activity
B37_01157	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B37_01158	COG0303	'Molybdopterin
B37_01159	COG1763	Mo-molybdopterin cofactor biosynthetic process
B37_01160	COG0314	molybdopterin synthase activity
B37_01161	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B37_01163	COG1132	(ABC) transporter
B37_01164	COG1132	(ABC) transporter
B37_01166	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B37_01167	COG1136	(ABC) transporter
B37_01168	COG0577	efflux transmembrane transporter activity
B37_01169	COG1349	DNA-binding transcription factor activity
B37_01170	COG1105	Belongs to the carbohydrate kinase PfkB family
B37_01171	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_01171	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_01171	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_01175	COG0488	(ABC) transporter
B37_01177	COG2309	aminopeptidase activity
B37_01179	COG1077	Cell shape determining protein MreB Mrl
B37_01180	COG2002	toxin-antitoxin pair type II binding
B37_01181	COG3852	Histidine kinase
B37_01182	COG0569	domain protein
B37_01183	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B37_01184	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B37_01186	COG0561	phosphatase activity
B37_01188	COG0242	peptide deformylase activity
B37_01190	COG0497	DNA recombination
B37_01191	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B37_01192	COG0022	dehydrogenase e1 component
B37_01193	COG0508	dehydrogenase complex catalyzes the overall conversion of
B37_01194	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B37_01196	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_01198	COG1982	Orn Lys Arg decarboxylase major
B37_01199	COG4476	Belongs to the UPF0223 family
B37_01200	COG4493	Belongs to the UPF0637 family
B37_01202	COG0483	inositol monophosphate 1-phosphatase activity
B37_01206	COG1595	DNA-templated transcription, initiation
B37_01211	COG1846	Transcriptional regulator
B37_01212	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B37_01213	COG4896	Protein conserved in bacteria
B37_01215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B37_01216	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B37_01217	COG2066	Belongs to the glutaminase family
B37_01218	COG4838	Belongs to the UPF0358 family
B37_01219	COG0772	Belongs to the SEDS family
B37_01220	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B37_01221	COG1612	heme a metabolic process
B37_01222	COG0109	protoheme IX farnesyltransferase activity
B37_01223	COG2010	Cytochrome c
B37_01223	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B37_01224	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B37_01225	COG1845	cytochrome c oxidase, subunit III
B37_01226	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B37_01227	COG3336	cytochrome c oxidase
B37_01229	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B37_01230	COG2340	Cysteine-rich secretory protein family
B37_01234	COG3679	Belongs to the UPF0342 family
B37_01235	COG4471	UPF0298 protein
B37_01237	COG0742	ribosomal rna small subunit methyltransferase
B37_01238	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B37_01239	COG3314	Sporulation integral membrane protein YlbJ
B37_01240	COG3480	Lon protease (S16) C-terminal proteolytic domain
B37_01241	COG1323	Belongs to the UPF0348 family
B37_01242	COG1399	metal-binding, possibly nucleic acid-binding protein
B37_01243	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B37_01245	COG0454	-acetyltransferase
B37_01246	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B37_01247	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B37_01248	COG2001	Belongs to the MraZ family
B37_01249	COG0275	rRNA processing
B37_01250	COG4839	cell division protein FtsL
B37_01252	COG0768	penicillin binding
B37_01254	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B37_01255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B37_01256	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B37_01257	COG0772	Belongs to the SEDS family
B37_01258	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B37_01259	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B37_01260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B37_01261	COG3879	Bacterial protein of unknown function (DUF881)
B37_01262	COG3879	Bacterial protein of unknown function (DUF881)
B37_01263	COG3856	small basic protein
B37_01264	COG0849	cell division
B37_01265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B37_01266	COG1404	Belongs to the peptidase S8 family
B37_01266	COG4412	M6 family metalloprotease domain protein
B37_01268	COG1404	Belongs to the peptidase S8 family
B37_01268	COG4412	M6 family metalloprotease domain protein
B37_01269	COG4412	M6 family metalloprotease domain protein
B37_01269	COG1404	Belongs to the peptidase S8 family
B37_01271	COG1191	sigma factor activity
B37_01272	COG1191	sigma factor activity
B37_01273	COG1119	ATPase activity
B37_01274	COG0500	methyltransferase
B37_01275	COG1873	PFAM PRC-barrel domain
B37_01277	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B37_01278	COG1799	cell septum assembly
B37_01279	COG0762	integral membrane protein
B37_01280	COG2302	S4 RNA-binding domain
B37_01281	COG3599	regulation of cell shape
B37_01282	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B37_01283	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B37_01284	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B37_01285	COG0564	pseudouridine synthase activity
B37_01286	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B37_01287	COG2233	PERMEase
B37_01288	COG0540	Belongs to the ATCase OTCase family
B37_01289	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B37_01290	COG0505	Belongs to the CarA family
B37_01291	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B37_01292	COG0543	2 iron, 2 sulfur cluster binding
B37_01293	COG0167	dihydroorotate dehydrogenase activity
B37_01294	COG0284	orotidine-5'-phosphate decarboxylase activity
B37_01295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B37_01297	COG0175	sulfate reduction
B37_01298	COG0306	phosphate transporter
B37_01299	COG2046	Belongs to the sulfate adenylyltransferase family
B37_01300	COG0529	Catalyzes the synthesis of activated sulfate
B37_01301	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B37_01302	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B37_01303	COG1648	precorrin-2 dehydrogenase activity
B37_01305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B37_01306	COG1561	YicC-like family, N-terminal region
B37_01307	COG2052	Domain of unknown function (DUF370)
B37_01308	COG0194	GDP metabolic process
B37_01309	COG1758	RNA polymerase activity
B37_01310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B37_01311	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B37_01312	COG0242	peptide deformylase activity
B37_01313	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B37_01314	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B37_01314	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B37_01315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B37_01316	COG0631	protein serine/threonine phosphatase activity
B37_01317	COG2815	serine threonine protein kinase
B37_01317	COG0515	serine threonine protein kinase
B37_01318	COG1162	GTPase activity
B37_01319	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B37_01320	COG1564	THIamine pyrophosphokinase
B37_01321	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B37_01322	COG1302	Protein conserved in bacteria
B37_01323	COG1461	Dihydroxyacetone kinase
B37_01324	COG1760	l-serine dehydratase
B37_01325	COG1760	l-serine dehydratase
B37_01326	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B37_01327	COG1349	DNA-binding transcription factor activity
B37_01328	COG0416	fatty acid biosynthetic process
B37_01329	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B37_01330	COG1028	Short-chain dehydrogenase reductase Sdr
B37_01331	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B37_01332	COG0571	ribonuclease III activity
B37_01333	COG1196	nuclear chromosome segregation
B37_01334	COG0552	protein localization to endoplasmic reticulum
B37_01335	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B37_01336	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B37_01337	COG0228	four-way junction DNA binding
B37_01338	COG1837	Belongs to the UPF0109 family
B37_01340	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B37_01341	COG0336	Belongs to the RNA methyltransferase TrmD family
B37_01342	COG0335	large ribosomal subunit rRNA binding
B37_01343	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B37_01344	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B37_01346	COG2257	FlhB HrpN YscU SpaS Family
B37_01347	COG0045	succinate-CoA ligase (ADP-forming) activity
B37_01348	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B37_01349	COG0758	DNA mediated transformation
B37_01350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B37_01351	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B37_01352	COG4974	Belongs to the 'phage' integrase family
B37_01353	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B37_01354	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B37_01355	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B37_01357	COG1815	bacterial-type flagellum-dependent cell motility
B37_01358	COG1558	bacterial-type flagellum-dependent cell motility
B37_01359	COG1677	Flagellar hook-basal body complex protein FliE
B37_01360	COG1766	The M ring may be actively involved in energy transduction
B37_01361	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B37_01362	COG1317	bacterial-type flagellum organization
B37_01363	COG1157	protein secretion by the type III secretion system
B37_01364	COG2882	bacterial-type flagellum organization
B37_01366	COG3144	bacterial-type flagellum assembly
B37_01367	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B37_01368	COG4786	Flagellar basal body rod
B37_01369	COG1580	Controls the rotational direction of flagella during chemotaxis
B37_01370	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B37_01371	COG1776	CheC inhibitor of MCP methylation
B37_01371	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B37_01372	COG2201	protein-glutamate methylesterase activity
B37_01373	COG3190	flagellar
B37_01374	COG1338	Plays a role in the flagellum-specific transport system
B37_01375	COG1987	bacterial-type flagellum assembly
B37_01376	COG1684	flagellar biosynthetic protein fliR
B37_01377	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B37_01378	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B37_01379	COG1419	protein localization to endoplasmic reticulum
B37_01380	COG0455	bacterial-type flagellum organization
B37_01381	COG2201	protein-glutamate methylesterase activity
B37_01382	COG0643	Histidine kinase
B37_01382	COG2198	Histidine kinase
B37_01383	COG0835	chemotaxis
B37_01384	COG1776	CheC inhibitor of MCP methylation
B37_01385	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B37_01386	COG1191	sigma factor activity
B37_01388	COG0052	Belongs to the universal ribosomal protein uS2 family
B37_01389	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B37_01390	COG0528	UMP kinase activity
B37_01391	COG0233	cytoplasmic translational termination
B37_01392	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B37_01393	COG4589	Belongs to the CDS family
B37_01394	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B37_01395	COG0750	zinc metalloprotease
B37_01396	COG0442	prolyl-tRNA aminoacylation
B37_01397	COG2176	DNA-directed DNA polymerase activity
B37_01403	COG0779	Required for maturation of 30S ribosomal subunits
B37_01404	COG0195	Participates in both transcription termination and antitermination
B37_01405	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B37_01406	COG1358	cellular component organization or biogenesis
B37_01407	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B37_01408	COG1550	Protein conserved in bacteria
B37_01409	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B37_01410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B37_01411	COG0196	riboflavin kinase activity
B37_01412	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B37_01413	COG1185	polyribonucleotide nucleotidyltransferase activity
B37_01414	COG0726	polysaccharide deacetylase
B37_01415	COG0612	Peptidase, M16
B37_01416	COG1873	PFAM PRC-barrel domain
B37_01417	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B37_01418	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B37_01419	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B37_01420	COG0527	aspartate kinase activity
B37_01422	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B37_01423	COG0740	serine-type endopeptidase activity
B37_01425	COG4980	gas vesicle protein
B37_01425	COG1674	ftsk spoiiie
B37_01426	COG2188	Transcriptional regulator
B37_01427	COG2814	Major facilitator Superfamily
B37_01428	COG0612	Peptidase, M16
B37_01429	COG0612	Peptidase, M16
B37_01430	COG0300	oxidoreductase activity
B37_01433	COG1426	Protein conserved in bacteria
B37_01434	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B37_01435	COG1546	Belongs to the CinA family
B37_01435	COG1058	Belongs to the CinA family
B37_01436	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B37_01437	COG1418	mRNA catabolic process
B37_01438	COG1692	metallophosphoesterase
B37_01439	COG2359	stage V sporulation protein S
B37_01441	COG1063	alcohol dehydrogenase
B37_01442	COG0156	8-amino-7-oxononanoate synthase activity
B37_01443	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B37_01444	COG4550	Control of competence regulator ComK, YlbF/YmcA
B37_01446	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B37_01447	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B37_01448	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B37_01449	COG5444	nuclease activity
B37_01452	COG0523	cobalamin synthesis protein
B37_01454	COG1247	-acetyltransferase
B37_01457	COG1231	oxidoreductase activity
B37_01458	COG3619	membrane
B37_01459	COG3263	regulation of cellular component size
B37_01460	COG2814	Major facilitator Superfamily
B37_01461	COG2814	Major facilitator Superfamily
B37_01462	COG2267	carboxylic ester hydrolase activity
B37_01463	COG0393	Putative heavy-metal-binding
B37_01464	COG0398	Pfam SNARE associated Golgi protein
B37_01465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B37_01466	COG1819	glycosyl
B37_01467	COG0531	amino acid
B37_01468	COG5577	PFAM Coat F domain
B37_01470	COG1388	LysM domain
B37_01470	COG3858	chitin binding
B37_01471	COG1309	transcriptional regulator
B37_01472	COG3631	Ketosteroid isomerase-related protein
B37_01473	COG0702	epimerase
B37_01475	COG1764	response to oxidative stress
B37_01476	COG2076	Multidrug Resistance protein
B37_01477	COG2076	Multidrug Resistance protein
B37_01480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B37_01481	COG1923	regulation of RNA biosynthetic process
B37_01483	COG1780	Probably involved in ribonucleotide reductase function
B37_01484	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_01485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B37_01486	COG4112	unkown
B37_01489	COG0822	iron-sulfur transferase activity
B37_01490	COG0735	belongs to the Fur family
B37_01491	COG1802	Transcriptional regulator
B37_01492	COG0697	spore germination
B37_01498	COG1309	transcriptional regulator
B37_01506	COG4282	regulation of fungal-type cell wall biogenesis
B37_01507	COG5444	nuclease activity
B37_01511	COG0464	growth
B37_01512	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B37_01513	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B37_01514	COG0789	Transcriptional regulator
B37_01515	COG0174	glutamine synthetase
B37_01523	COG1073	alpha beta
B37_01532	COG1309	transcriptional regulator
B37_01533	COG2076	Multidrug Resistance protein
B37_01534	COG2076	Multidrug Resistance protein
B37_01536	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B37_01539	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_01540	COG3546	catalase activity
B37_01545	COG1846	Transcriptional regulator
B37_01546	COG0778	Nitroreductase
B37_01547	COG0346	lactoylglutathione lyase activity
B37_01548	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B37_01549	COG0655	NAD(P)H dehydrogenase (quinone) activity
B37_01552	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B37_01553	COG3209	COG3209 Rhs family protein
B37_01554	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B37_01555	COG1388	LysM domain
B37_01556	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B37_01557	COG4224	UPF0291 protein
B37_01558	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B37_01560	COG3763	UPF0154 protein
B37_01562	COG0785	Cytochrome C biogenesis protein
B37_01563	COG2201	protein-glutamate methylesterase activity
B37_01564	COG4846	Membrane protein involved in cytochrome C biogenesis
B37_01566	COG0071	Belongs to the small heat shock protein (HSP20) family
B37_01567	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B37_01568	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_01572	COG0824	Thioesterase
B37_01576	COG4841	protein insertion into membrane
B37_01577	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B37_01578	COG1832	CoA-binding protein
B37_01579	COG0187	DNA topoisomerase II activity
B37_01580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B37_01581	COG1609	Transcriptional regulator
B37_01584	COG2160	L-arabinose isomerase activity
B37_01589	COG1115	amino acid carrier protein
B37_01591	COG2181	nitrate reductase activity
B37_01592	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B37_01593	COG1140	nitrate reductase beta subunit
B37_01594	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B37_01598	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B37_01600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B37_01601	COG2223	nitrite transmembrane transporter activity
B37_01603	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B37_01605	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
B37_01607	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B37_01609	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B37_01611	COG0492	ferredoxin-NADP+ reductase activity
B37_01614	COG3420	alginic acid biosynthetic process
B37_01615	COG1114	Component of the transport system for branched-chain amino acids
B37_01616	COG1064	alcohol dehydrogenase
B37_01617	COG0789	Transcriptional regulator
B37_01622	COG1024	Enoyl-CoA hydratase
B37_01623	COG1012	belongs to the aldehyde dehydrogenase family
B37_01624	COG2084	Dehydrogenase
B37_01625	COG1960	acyl-CoA dehydrogenase activity
B37_01626	COG1482	cell wall glycoprotein biosynthetic process
B37_01627	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_01627	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_01627	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_01631	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_01631	COG3711	transcriptional antiterminator
B37_01634	COG1725	Transcriptional regulator
B37_01635	COG1028	Short-chain dehydrogenase reductase Sdr
B37_01636	COG1312	Catalyzes the dehydration of D-mannonate
B37_01639	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B37_01641	COG1609	Transcriptional regulator
B37_01642	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B37_01643	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B37_01644	COG0640	Transcriptional regulator
B37_01645	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B37_01648	COG1649	PFAM Uncharacterised BCR, COG1649
B37_01649	COG2404	hydrolase activity, acting on ester bonds
B37_01650	COG2404	hydrolase activity, acting on ester bonds
B37_01651	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B37_01653	COG2027	D-alanyl-D-alanine carboxypeptidase
B37_01654	COG2323	membrane
B37_01655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B37_01657	COG2323	membrane
B37_01660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B37_01663	COG2801	Transposase and inactivated derivatives
B37_01664	COG3546	catalase activity
B37_01668	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_01672	COG1252	NADH dehydrogenase
B37_01675	COG0166	Belongs to the GPI family
B37_01677	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B37_01678	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B37_01679	COG1024	Enoyl-CoA hydratase
B37_01680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B37_01681	COG0511	ligase activity, forming carbon-carbon bonds
B37_01682	COG0439	Biotin carboxylase
B37_01683	COG0318	PFAM AMP-dependent synthetase and ligase
B37_01684	COG1960	acyl-CoA dehydrogenase activity
B37_01685	COG2249	NAD(P)H dehydrogenase (quinone) activity
B37_01686	COG1733	regulation of RNA biosynthetic process
B37_01687	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B37_01688	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B37_01691	COG2323	membrane
B37_01692	COG0306	phosphate transporter
B37_01693	COG0175	sulfate reduction
B37_01694	COG1809	phosphosulfolactate synthase activity
B37_01695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_01696	COG4948	Mandelate Racemase Muconate Lactonizing
B37_01697	COG2814	Major facilitator Superfamily
B37_01698	COG0463	Glycosyl transferase, family 2
B37_01701	COG0493	'glutamate synthase
B37_01702	COG0067	glutamate synthase
B37_01702	COG0070	glutamate synthase
B37_01702	COG0069	glutamate synthase activity
B37_01703	COG0583	DNA-binding transcription factor activity
B37_01707	COG1846	Transcriptional regulator
B37_01709	COG1132	(ABC) transporter
B37_01711	COG0300	oxidoreductase activity
B37_01712	COG3848	Pyruvate phosphate dikinase
B37_01712	COG0574	Belongs to the PEP-utilizing enzyme family
B37_01713	COG0477	Major facilitator Superfamily
B37_01714	COG0243	molybdopterin cofactor binding
B37_01715	COG1846	Transcriptional regulator
B37_01716	COG2814	Major facilitator Superfamily
B37_01717	COG0531	amino acid
B37_01719	COG0531	amino acid
B37_01720	COG0531	amino acid
B37_01721	COG0697	spore germination
B37_01723	COG0840	transmembrane signaling receptor activity
B37_01724	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B37_01725	COG1404	Belongs to the peptidase S8 family
B37_01727	COG1309	transcriptional regulator
B37_01728	COG1846	Transcriptional regulator
B37_01734	COG1309	transcriptional regulator
B37_01735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_01736	COG3708	Transcriptional regulator
B37_01738	COG2378	regulation of single-species biofilm formation
B37_01740	COG0640	Transcriptional regulator
B37_01741	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_01743	COG0531	amino acid
B37_01744	COG0741	lytic transglycosylase activity
B37_01745	COG1086	Polysaccharide biosynthesis protein
B37_01749	COG2322	membrane
B37_01752	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_01753	COG3584	3D domain protein
B37_01753	COG1388	LysM domain
B37_01754	COG0514	ATP-dependent DNA helicase (RecQ)
B37_01759	COG2315	Protein conserved in bacteria
B37_01761	COG2427	Protein of unknown function (DUF1641)
B37_01762	COG3383	formate dehydrogenase (NAD+) activity
B37_01764	COG5444	nuclease activity
B37_01766	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B37_01776	COG0402	S-adenosylhomocysteine deaminase activity
B37_01779	COG2267	carboxylic ester hydrolase activity
B37_01782	COG1280	lysine exporter protein (LysE YggA)
B37_01783	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B37_01785	COG0574	Belongs to the PEP-utilizing enzyme family
B37_01785	COG3848	Pyruvate phosphate dikinase
B37_01786	COG1309	transcriptional regulator
B37_01789	COG2318	DinB family
B37_01790	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B37_01791	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B37_01794	COG1012	belongs to the aldehyde dehydrogenase family
B37_01795	COG2814	Major facilitator Superfamily
B37_01798	COG1657	PFAM Prenyltransferase squalene oxidase
B37_01799	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B37_01801	COG0733	neurotransmitter:sodium symporter activity
B37_01802	COG0385	Bile acid
B37_01803	COG0508	dehydrogenase complex catalyzes the overall conversion of
B37_01804	COG0567	Dehydrogenase, E1 component
B37_01805	COG4548	von Willebrand factor, type A
B37_01806	COG0714	Associated with various cellular activities
B37_01807	COG2032	superoxide dismutase activity
B37_01808	COG0791	NLP P60 protein
B37_01808	COG1388	LysM domain
B37_01809	COG0534	Mate efflux family protein
B37_01810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B37_01811	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B37_01813	COG2962	Rard protein
B37_01816	COG4305	rare lipoprotein A
B37_01818	COG1028	Short-chain dehydrogenase reductase Sdr
B37_01819	COG1733	regulation of RNA biosynthetic process
B37_01820	COG0778	Nitroreductase
B37_01821	COG0400	carboxylic ester hydrolase activity
B37_01823	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_01824	COG2801	Transposase and inactivated derivatives
B37_01826	COG3409	Peptidoglycan-binding domain 1 protein
B37_01826	COG0793	Belongs to the peptidase S41A family
B37_01827	COG2226	methyltransferase
B37_01829	COG1876	peptidase activity
B37_01830	COG0813	purine-nucleoside phosphorylase activity
B37_01831	COG0701	Predicted permease
B37_01835	COG0671	phosphoesterase, PA-phosphatase related
B37_01839	COG4479	Belongs to the UPF0346 family
B37_01841	COG1509	lysine 2,3-aminomutase activity
B37_01842	COG0456	acetyltransferase
B37_01843	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B37_01844	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B37_01845	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B37_01846	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B37_01848	COG0456	acetyltransferase
B37_01849	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B37_01850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B37_01851	COG1846	Transcriptional regulator
B37_01853	COG3706	GGDEF domain
B37_01854	COG0534	Mate efflux family protein
B37_01857	COG4698	Protein conserved in bacteria
B37_01858	COG2755	lipolytic protein G-D-S-L family
B37_01859	COG1999	signal sequence binding
B37_01862	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B37_01863	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B37_01864	COG1272	protein, Hemolysin III
B37_01865	COG0204	Acyl-transferase
B37_01866	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B37_01867	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B37_01869	COG2136	Putative SAM-dependent methyltransferase
B37_01869	COG2521	methyltransferase
B37_01871	COG0129	dihydroxy-acid dehydratase activity
B37_01872	COG1413	lyase activity
B37_01873	COG1418	mRNA catabolic process
B37_01874	COG0386	Belongs to the glutathione peroxidase family
B37_01875	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B37_01876	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B37_01877	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B37_01879	COG1278	Cold shock
B37_01883	COG0328	RNA-DNA hybrid ribonuclease activity
B37_01884	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B37_01885	COG0328	RNA-DNA hybrid ribonuclease activity
B37_01887	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B37_01890	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B37_01891	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B37_01892	COG1755	Isoprenylcysteine carboxyl methyltransferase
B37_01893	COG3424	synthase
B37_01894	COG0456	acetyltransferase
B37_01895	COG2233	PERMEase
B37_01896	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B37_01897	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B37_01898	COG1199	ATP-dependent helicase activity
B37_01901	COG0116	Belongs to the methyltransferase superfamily
B37_01902	COG3599	regulation of cell shape
B37_01903	COG4474	Belongs to the UPF0398 family
B37_01906	COG3359	exonuclease
B37_01907	COG1205	dead DEAH box helicase
B37_01907	COG1111	helicase
B37_01908	COG2190	(PTS) system
B37_01909	COG0071	Belongs to the small heat shock protein (HSP20) family
B37_01916	COG3331	DNA recombination
B37_01917	COG4499	WXG100 protein secretion system (Wss), protein YukC
B37_01917	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B37_01919	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B37_01920	COG3935	DnaD domain protein
B37_01921	COG0017	Asparaginyl-tRNA synthetase
B37_01922	COG0436	Aminotransferase
B37_01923	COG5353	protein conserved in bacteria
B37_01925	COG1199	ATP-dependent helicase activity
B37_01925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B37_01926	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B37_01927	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B37_01928	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B37_01930	COG0617	tRNA 3'-terminal CCA addition
B37_01931	COG0438	transferase activity, transferring glycosyl groups
B37_01932	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B37_01933	COG1803	Methylglyoxal synthase
B37_01934	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B37_01935	COG1694	Mazg nucleotide pyrophosphohydrolase
B37_01936	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_01938	COG4347	Protein of unknown function (DUF1405)
B37_01939	COG2010	Cytochrome c
B37_01939	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B37_01940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B37_01941	COG0723	plastoquinol--plastocyanin reductase activity
B37_01943	COG5582	Belongs to the UPF0302 family
B37_01944	COG0457	Tetratricopeptide repeat
B37_01945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B37_01946	COG0287	Prephenate dehydrogenase
B37_01947	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B37_01948	COG0159	tryptophan synthase activity
B37_01949	COG0133	tryptophan synthase activity
B37_01950	COG0135	phosphoribosylanthranilate isomerase activity
B37_01951	COG0134	indole-3-glycerol-phosphate synthase activity
B37_01952	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B37_01953	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B37_01954	COG4401	Chorismate mutase type I
B37_01955	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B37_01956	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B37_01957	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B37_01958	COG0105	UTP biosynthetic process
B37_01959	COG0142	geranyltranstransferase activity
B37_01960	COG2226	methyltransferase
B37_01961	COG0142	geranyltranstransferase activity
B37_01964	COG0776	regulation of translation
B37_01965	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B37_01969	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B37_01970	COG1160	GTP binding
B37_01975	COG1304	FMN binding
B37_01976	COG0539	negative regulation of cytoplasmic translation
B37_01977	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B37_01979	COG2959	enzyme of heme biosynthesis
B37_01980	COG3773	Cell wall hydrolase
B37_01980	COG3409	Peptidoglycan-binding domain 1 protein
B37_01981	COG2339	peptidase activity
B37_01983	COG0492	ferredoxin-NADP+ reductase activity
B37_01984	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B37_01985	COG4862	establishment of competence for transformation
B37_01986	COG1408	metallophosphoesterase
B37_01988	COG1388	LysM domain
B37_01989	COG1266	CAAX protease self-immunity
B37_01990	COG0514	ATP-dependent DNA helicase (RecQ)
B37_01991	COG4955	Helix-turn-helix domain
B37_01992	COG1141	Ferredoxin
B37_01993	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B37_01994	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B37_01995	COG0739	heme binding
B37_01997	COG1595	DNA-templated transcription, initiation
B37_01999	COG0726	polysaccharide deacetylase
B37_02001	COG5002	protein histidine kinase activity
B37_02002	COG0745	RESPONSE REGULATOR receiver
B37_02003	COG5002	protein histidine kinase activity
B37_02004	COG0745	RESPONSE REGULATOR receiver
B37_02005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B37_02006	COG1333	cytochrome c biogenesis protein
B37_02007	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_02008	COG1187	pseudouridine synthase activity
B37_02009	COG0700	Nucleoside recognition
B37_02010	COG2715	membrane protein required for spore maturation
B37_02011	COG1686	Belongs to the peptidase S11 family
B37_02013	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B37_02014	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B37_02016	COG1547	Domain of unknown function (DUF309)
B37_02017	COG0456	acetyltransferase
B37_02018	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B37_02019	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B37_02019	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B37_02020	COG0307	riboflavin synthase, alpha
B37_02021	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B37_02021	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B37_02026	COG0457	Tetratricopeptide repeat
B37_02027	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B37_02028	COG4086	secreted protein
B37_02029	COG4195	phage-related replication protein
B37_02030	COG0019	diaminopimelate decarboxylase activity
B37_02032	COG0697	spore germination
B37_02035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B37_02040	COG2172	sigma factor antagonist activity
B37_02042	COG1686	Belongs to the peptidase S11 family
B37_02043	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B37_02044	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B37_02045	COG4974	Belongs to the 'phage' integrase family
B37_02047	COG0735	belongs to the Fur family
B37_02048	COG1300	Membrane
B37_02049	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_02051	COG1953	Uracil, thiamine, allantoin
B37_02052	COG1953	Uracil, thiamine, allantoin
B37_02055	COG2153	protein acetylation
B37_02056	COG1379	DNA repair
B37_02057	COG0494	nUDIX hydrolase
B37_02059	COG1309	transcriptional regulator
B37_02061	COG0667	Aldo Keto reductase
B37_02063	COG1073	alpha beta
B37_02065	COG4918	Iron-sulphur cluster biosynthesis
B37_02067	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B37_02067	COG0456	acetyltransferase
B37_02068	COG2329	Antibiotic biosynthesis monooxygenase
B37_02069	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B37_02071	COG0747	negative chemotaxis
B37_02072	COG0601	transmembrane transport
B37_02073	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B37_02074	COG0444	Belongs to the ABC transporter superfamily
B37_02075	COG0534	Mate efflux family protein
B37_02079	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B37_02081	COG2211	Major facilitator Superfamily
B37_02082	COG0346	lactoylglutathione lyase activity
B37_02083	COG1072	(Pantothenic acid kinase))
B37_02089	COG4195	phage-related replication protein
B37_02090	COG0300	oxidoreductase activity
B37_02091	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_02092	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B37_02093	COG4187	Peptidase family M20/M25/M40
B37_02094	COG1902	pentaerythritol trinitrate reductase activity
B37_02096	COG0596	Alpha beta hydrolase
B37_02097	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B37_02098	COG1234	tRNA 3'-trailer cleavage
B37_02099	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B37_02103	COG2188	Transcriptional regulator
B37_02104	COG2723	6-phospho-beta-galactosidase activity
B37_02105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_02106	COG1447	Phosphotransferase system cellobiose-specific component IIA
B37_02107	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_02108	COG1785	Belongs to the alkaline phosphatase family
B37_02109	COG1028	Short-chain dehydrogenase reductase Sdr
B37_02110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B37_02111	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B37_02113	COG0706	membrane insertase activity
B37_02114	COG2195	Cleaves the N-terminal amino acid of tripeptides
B37_02115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B37_02116	COG4129	membrane
B37_02117	COG1126	abc transporter atp-binding protein
B37_02118	COG0765	amino acid transport
B37_02119	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B37_02122	COG1597	lipid kinase activity
B37_02123	COG0508	dehydrogenase complex catalyzes the overall conversion of
B37_02124	COG0022	dehydrogenase e1 component
B37_02125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B37_02126	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B37_02127	COG3426	butyrate kinase activity
B37_02129	COG0280	phosphate acetyltransferase
B37_02130	COG3290	protein histidine kinase activity
B37_02130	COG3829	transcription factor binding
B37_02132	COG0584	glycerophosphoryl diester phosphodiesterase
B37_02133	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_02135	COG1045	serine acetyltransferase
B37_02137	COG0745	RESPONSE REGULATOR receiver
B37_02138	COG0750	zinc metalloprotease
B37_02139	COG0497	DNA recombination
B37_02140	COG1438	arginine binding
B37_02141	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B37_02142	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B37_02143	COG0142	geranyltranstransferase activity
B37_02144	COG1722	exodeoxyribonuclease VII activity
B37_02145	COG1570	exodeoxyribonuclease VII activity
B37_02146	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B37_02147	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B37_02148	COG1302	Protein conserved in bacteria
B37_02149	COG0439	Biotin carboxylase
B37_02150	COG0511	ligase activity, forming carbon-carbon bonds
B37_02158	COG3854	ATPases associated with a variety of cellular activities
B37_02160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B37_02161	COG0006	proline dipeptidase activity
B37_02162	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B37_02164	COG3872	metal-dependent enzyme
B37_02166	COG1752	Esterase of the alpha-beta hydrolase superfamily
B37_02167	COG1321	iron dependent repressor
B37_02168	COG0095	Lipoate-protein ligase
B37_02169	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B37_02170	COG2113	Glycine betaine
B37_02171	COG4176	ABC-type proline glycine betaine transport system permease component
B37_02172	COG0517	IMP dehydrogenase activity
B37_02172	COG4175	Glycine betaine
B37_02173	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B37_02174	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B37_02175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B37_02176	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B37_02181	COG0681	Belongs to the peptidase S26 family
B37_02186	COG4940	Competence protein ComGF
B37_02187	COG4970	Tfp pilus assembly protein FimT
B37_02188	COG4537	Required for transformation and DNA binding
B37_02189	COG1459	type II secretion system
B37_02190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B37_02191	COG1366	Belongs to the anti-sigma-factor antagonist family
B37_02193	COG1393	Belongs to the ArsC family
B37_02195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_02197	COG0011	TIGRFAM Protein of
B37_02199	COG2866	Carboxypeptidase
B37_02200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_02202	COG1368	sulfuric ester hydrolase activity
B37_02203	COG1940	carbohydrate kinase activity
B37_02204	COG4483	Protein conserved in bacteria
B37_02205	COG0697	spore germination
B37_02206	COG0705	Rhomboid family
B37_02206	COG0457	Tetratricopeptide repeat
B37_02208	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B37_02209	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B37_02210	COG0438	transferase activity, transferring glycosyl groups
B37_02213	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B37_02214	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B37_02215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B37_02216	COG0581	inorganic phosphate transmembrane transporter activity
B37_02217	COG0573	inorganic phosphate transmembrane transporter activity
B37_02218	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B37_02220	COG0477	Major facilitator Superfamily
B37_02221	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B37_02222	COG2839	Protein conserved in bacteria
B37_02223	COG5521	maltodextrose utilization protein MalA
B37_02224	COG1388	LysM domain
B37_02225	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B37_02226	COG4709	membrane
B37_02227	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
B37_02228	COG0735	belongs to the Fur family
B37_02229	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B37_02230	COG1121	(ABC) transporter
B37_02231	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_02233	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B37_02234	COG0513	Belongs to the DEAD box helicase family
B37_02236	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B37_02237	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B37_02238	COG2384	SAM-dependent methyltransferase
B37_02249	COG5444	nuclease activity
B37_02252	COG2010	Cytochrome c
B37_02253	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B37_02254	COG0358	DNA primase activity
B37_02255	COG1671	Belongs to the UPF0178 family
B37_02256	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B37_02257	COG0517	IMP dehydrogenase activity
B37_02258	COG0751	glycine-tRNA ligase activity
B37_02259	COG0752	glycyl-tRNA synthetase alpha subunit
B37_02260	COG1381	Involved in DNA repair and RecF pathway recombination
B37_02262	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B37_02263	COG0295	cytidine deaminase activity
B37_02264	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B37_02265	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B37_02266	COG1480	7TM receptor with intracellular HD hydrolase
B37_02267	COG1702	phosphate starvation-inducible protein PhoH
B37_02268	COG0561	phosphatase activity
B37_02271	COG4864	UPF0365 protein
B37_02272	COG1030	water channel activity
B37_02273	COG1610	YqeY-like protein
B37_02274	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B37_02275	COG1283	sodium-dependent phosphate transmembrane transporter activity
B37_02276	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B37_02277	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B37_02278	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B37_02279	COG2264	protein methyltransferase activity
B37_02280	COG0484	heat shock protein binding
B37_02281	COG0443	Heat shock 70 kDa protein
B37_02282	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B37_02283	COG1420	regulation of RNA biosynthetic process
B37_02284	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B37_02285	COG0481	GTPase activity
B37_02287	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_02288	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B37_02289	COG0268	Binds directly to 16S ribosomal RNA
B37_02290	COG1466	dna polymerase III delta subunit
B37_02292	COG0658	competence protein
B37_02292	COG2333	competence protein COMEC
B37_02293	COG2131	deaminase
B37_02294	COG1596	polysaccharide export
B37_02294	COG1555	photosystem II stabilization
B37_02295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B37_02296	COG2226	methyltransferase
B37_02297	COG0799	negative regulation of ribosome biogenesis
B37_02298	COG1713	HD superfamily hydrolase involved in NAD metabolism
B37_02299	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B37_02300	COG1534	Rna-binding protein
B37_02301	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B37_02302	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B37_02303	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B37_02305	COG2755	lipolytic protein G-D-S-L family
B37_02306	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B37_02307	COG5609	conserved protein (DUF2294)
B37_02308	COG3383	formate dehydrogenase (NAD+) activity
B37_02309	COG2427	Protein of unknown function (DUF1641)
B37_02316	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_02324	COG1136	(ABC) transporter
B37_02325	COG0577	efflux transmembrane transporter activity
B37_02337	COG2197	response regulator
B37_02338	COG4585	Histidine kinase
B37_02339	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_02340	COG0730	response to heat
B37_02341	COG0425	Belongs to the sulfur carrier protein TusA family
B37_02342	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B37_02342	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_02343	COG0425	Belongs to the sulfur carrier protein TusA family
B37_02343	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B37_02344	COG2210	Belongs to the sulfur carrier protein TusA family
B37_02345	COG1937	Protein conserved in bacteria
B37_02349	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B37_02351	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B37_02352	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B37_02353	COG1733	regulation of RNA biosynthetic process
B37_02354	COG3239	Fatty acid desaturase
B37_02355	COG4585	Histidine kinase
B37_02356	COG2197	response regulator
B37_02357	COG0492	ferredoxin-NADP+ reductase activity
B37_02358	COG0747	negative chemotaxis
B37_02359	COG0601	transmembrane transport
B37_02361	COG0444	Belongs to the ABC transporter superfamily
B37_02362	COG4608	Belongs to the ABC transporter superfamily
B37_02366	COG1028	Short-chain dehydrogenase reductase Sdr
B37_02369	COG2124	cytochrome p450
B37_02370	COG0730	response to heat
B37_02372	COG1028	Short-chain dehydrogenase reductase Sdr
B37_02373	COG1621	beta-fructofuranosidase activity
B37_02374	COG3716	PTS system mannose fructose sorbose family IID component
B37_02375	COG3715	PTS system
B37_02376	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_02377	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_02378	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B37_02378	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B37_02379	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B37_02379	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B37_02383	COG2169	Transcriptional regulator
B37_02384	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B37_02385	COG0656	L-ascorbic acid biosynthetic process
B37_02386	COG2814	Major facilitator Superfamily
B37_02387	COG1733	regulation of RNA biosynthetic process
B37_02388	COG3340	Belongs to the peptidase S51 family
B37_02389	COG1587	Uroporphyrinogen-III synthase
B37_02391	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_02392	COG0583	DNA-binding transcription factor activity
B37_02393	COG2814	Major facilitator Superfamily
B37_02395	COG2124	cytochrome p450
B37_02395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B37_02396	COG1309	transcriptional regulator
B37_02397	COG1404	Belongs to the peptidase S8 family
B37_02398	COG2226	methyltransferase
B37_02402	COG0626	cystathionine gamma-synthase activity
B37_02403	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B37_02404	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B37_02405	COG2226	methyltransferase
B37_02408	COG0768	penicillin binding
B37_02409	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B37_02410	COG0572	uridine kinase
B37_02414	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B37_02415	COG3906	Belongs to the UPF0473 family
B37_02416	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B37_02417	COG4472	Bacterial protein of unknown function (DUF965)
B37_02418	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B37_02419	COG0628	permease
B37_02421	COG3881	PFAM PRC-barrel domain
B37_02422	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B37_02423	COG0457	Tetratricopeptide repeat
B37_02424	COG0482	sulfurtransferase activity
B37_02425	COG1104	cysteine desulfurase activity
B37_02426	COG1959	2 iron, 2 sulfur cluster binding
B37_02427	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B37_02428	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B37_02429	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B37_02430	COG0124	histidyl-tRNA synthetase
B37_02432	COG4991	sh3 domain protein
B37_02432	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_02432	COG3103	Sh3 type 3 domain protein
B37_02433	COG1490	D-aminoacyl-tRNA deacylase activity
B37_02434	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B37_02435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B37_02436	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B37_02436	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B37_02437	COG5416	Lipopolysaccharide assembly protein A domain
B37_02438	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B37_02438	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B37_02440	COG2244	polysaccharide biosynthetic process
B37_02441	COG2323	membrane
B37_02443	COG1862	Preprotein translocase
B37_02444	COG0343	queuine tRNA-ribosyltransferase activity
B37_02445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B37_02447	COG2255	four-way junction helicase activity
B37_02448	COG0632	four-way junction helicase activity
B37_02450	COG2112	serine threonine protein kinase
B37_02453	COG2318	DinB family
B37_02454	COG4195	phage-related replication protein
B37_02457	COG0217	transcriptional regulatory protein
B37_02460	COG1388	LysM domain
B37_02461	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B37_02462	COG0157	Belongs to the NadC ModD family
B37_02463	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B37_02464	COG1104	cysteine desulfurase activity
B37_02465	COG1827	regulation of RNA biosynthetic process
B37_02466	COG0077	Prephenate dehydratase
B37_02467	COG4492	Belongs to the UPF0735 family
B37_02468	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B37_02469	COG3290	protein histidine kinase activity
B37_02470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B37_02471	COG2868	ribosomal protein
B37_02472	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B37_02473	COG1994	Peptidase M50
B37_02474	COG0739	heme binding
B37_02475	COG3832	glyoxalase III activity
B37_02476	COG0640	Transcriptional regulator
B37_02477	COG2894	cell division
B37_02478	COG0850	regulation of cytokinetic process
B37_02479	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B37_02480	COG1792	Involved in formation and maintenance of cell shape
B37_02481	COG1077	Cell shape determining protein MreB Mrl
B37_02482	COG2003	Belongs to the UPF0758 family
B37_02486	COG0457	Tetratricopeptide repeat
B37_02487	COG5444	nuclease activity
B37_02496	COG1705	Flagellar rod assembly protein muramidase FlgJ
B37_02510	COG4626	Terminase
B37_02510	COG1802	Transcriptional regulator
B37_02537	COG2003	Belongs to the UPF0758 family
B37_02538	COG0424	maF-like protein
B37_02540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B37_02541	COG0285	dihydrofolate synthase activity
B37_02542	COG0525	valine-tRNA ligase activity
B37_02544	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B37_02545	COG1388	LysM domain
B37_02546	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B37_02547	COG0113	porphobilinogen synthase activity
B37_02548	COG1587	Uroporphyrinogen-III synthase
B37_02549	COG0181	hydroxymethylbilane synthase activity
B37_02550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B37_02551	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B37_02553	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B37_02554	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B37_02555	COG0470	DNA polymerase III
B37_02555	COG1067	ATP-dependent peptidase activity
B37_02556	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B37_02557	COG0544	peptidyl-prolyl cis-trans isomerase activity
B37_02558	COG0457	Tetratricopeptide repeat
B37_02558	COG1477	protein flavinylation
B37_02559	COG0066	3-isopropylmalate dehydratase activity
B37_02560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B37_02561	COG0473	3-isopropylmalate dehydrogenase activity
B37_02562	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B37_02563	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B37_02564	COG0440	acetolactate synthase activity
B37_02565	COG0028	Belongs to the TPP enzyme family
B37_02566	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B37_02568	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B37_02571	COG5518	Phage portal protein
B37_02572	COG1783	phage Terminase large subunit
B37_02579	COG5444	nuclease activity
B37_02580	COG0457	Tetratricopeptide repeat
B37_02585	COG0622	Phosphoesterase
B37_02586	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B37_02587	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B37_02588	COG5401	PFAM Sporulation and spore germination
B37_02589	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B37_02590	COG1846	Transcriptional regulator
B37_02591	COG2197	response regulator
B37_02592	COG4221	oxidoreductase activity
B37_02593	COG0824	Thioesterase
B37_02594	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B37_02595	COG1053	succinate dehydrogenase
B37_02596	COG2009	succinate dehydrogenase
B37_02597	COG1719	4-vinyl reductase, 4VR
B37_02598	COG0527	aspartate kinase activity
B37_02599	COG0322	excinuclease ABC activity
B37_02600	COG3118	belongs to the thioredoxin family
B37_02601	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B37_02602	COG2086	electron transfer activity
B37_02603	COG1024	Enoyl-CoA hydratase
B37_02604	COG1309	transcriptional regulator
B37_02605	COG0318	PFAM AMP-dependent synthetase and ligase
B37_02606	COG3766	membrane
B37_02607	COG1193	negative regulation of DNA recombination
B37_02608	COG1796	DNA polymerase
B37_02608	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B37_02609	COG1286	toxin biosynthetic process
B37_02610	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B37_02611	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B37_02613	COG2801	Transposase and inactivated derivatives
B37_02617	COG1137	ATPase activity
B37_02620	COG0072	phenylalanine-tRNA ligase activity
B37_02620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B37_02621	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B37_02622	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B37_02624	COG1966	Carbon starvation protein
B37_02627	COG0395	ABC-type sugar transport system, permease component
B37_02628	COG1175	transmembrane transport
B37_02629	COG1653	transport
B37_02630	COG0371	Dehydrogenase
B37_02631	COG0235	Class ii aldolase
B37_02632	COG1069	ribulokinase activity
B37_02633	COG2160	L-arabinose isomerase activity
B37_02634	COG3507	Belongs to the glycosyl hydrolase 43 family
B37_02635	COG1363	Peptidase, m42
B37_02637	COG3326	Membrane
B37_02638	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B37_02639	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B37_02640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B37_02641	COG1346	cytolysis
B37_02643	COG3540	Alkaline phosphatase
B37_02644	COG3279	Response regulator of the LytR AlgR family
B37_02645	COG3275	phosphorelay sensor kinase activity
B37_02648	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B37_02650	COG0398	Pfam SNARE associated Golgi protein
B37_02651	COG1484	DNA-dependent DNA replication
B37_02652	COG3611	Membrane attachment protein
B37_02653	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B37_02655	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B37_02656	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B37_02657	COG3866	Pectate lyase
B37_02658	COG0237	dephospho-CoA kinase activity
B37_02659	COG1971	Probably functions as a manganese efflux pump
B37_02660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B37_02661	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B37_02661	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B37_02662	COG5002	protein histidine kinase activity
B37_02663	COG0745	RESPONSE REGULATOR receiver
B37_02664	COG0039	L-malate dehydrogenase activity
B37_02665	COG0538	isocitrate dehydrogenase activity
B37_02666	COG0372	Belongs to the citrate synthase family
B37_02667	COG2707	UPF0756 membrane protein
B37_02668	COG0628	permease
B37_02669	COG3030	protein affecting phage T7 exclusion by the F plasmid
B37_02671	COG0205	6-phosphofructokinase activity
B37_02672	COG0825	malonyl-CoA metabolic process
B37_02673	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B37_02674	COG0281	malic enzyme
B37_02675	COG0587	DNA-directed DNA polymerase activity
B37_02679	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B37_02681	COG4109	DRTGG domain
B37_02682	COG1695	Transcriptional regulator
B37_02683	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B37_02684	COG1028	Short-chain dehydrogenase reductase Sdr
B37_02686	COG0165	Argininosuccinate lyase
B37_02687	COG0137	argininosuccinate synthase activity
B37_02688	COG0521	Mo-molybdopterin cofactor biosynthetic process
B37_02689	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B37_02690	COG0827	DNA restriction-modification system
B37_02691	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B37_02692	COG3874	Sporulation protein YtfJ
B37_02694	COG1714	RDD family
B37_02695	COG0616	signal peptide processing
B37_02696	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B37_02697	COG1566	PFAM secretion protein HlyD family protein
B37_02698	COG0477	Major facilitator Superfamily
B37_02700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B37_02702	COG0301	tRNA thio-modification
B37_02703	COG1104	cysteine desulfurase activity
B37_02704	COG1114	Component of the transport system for branched-chain amino acids
B37_02706	COG2801	Transposase and inactivated derivatives
B37_02707	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B37_02708	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B37_02709	COG1309	transcriptional regulator
B37_02710	COG1956	GAF domain-containing protein
B37_02711	COG2199	diguanylate cyclase activity
B37_02711	COG2203	Gaf domain
B37_02712	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B37_02715	COG3152	Membrane
B37_02716	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B37_02717	COG1522	sequence-specific DNA binding
B37_02719	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B37_02720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B37_02721	COG0454	-acetyltransferase
B37_02722	COG0517	IMP dehydrogenase activity
B37_02723	COG0123	including yeast histone deacetylase and acetoin utilization protein
B37_02724	COG1360	Flagellar Motor Protein
B37_02725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B37_02726	COG1609	Transcriptional regulator
B37_02727	COG1605	Chorismate mutase
B37_02727	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B37_02730	COG3118	belongs to the thioredoxin family
B37_02731	COG4980	gas vesicle protein
B37_02732	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B37_02733	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B37_02734	COG1674	ftsk spoiiie
B37_02735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B37_02736	COG4848	Belongs to the UPF0354 family
B37_02737	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_02739	COG1363	Peptidase, m42
B37_02740	COG5584	Small secreted protein
B37_02741	COG0281	malic enzyme
B37_02742	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B37_02743	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B37_02745	COG0510	thiamine kinase activity
B37_02746	COG1523	belongs to the glycosyl hydrolase 13 family
B37_02747	COG1523	belongs to the glycosyl hydrolase 13 family
B37_02748	COG1597	lipid kinase activity
B37_02750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B37_02751	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B37_02753	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B37_02754	COG2252	PERMEase
B37_02755	COG1349	DNA-binding transcription factor activity
B37_02756	COG1187	pseudouridine synthase activity
B37_02757	COG2244	polysaccharide biosynthetic process
B37_02758	COG2081	HI0933 family
B37_02759	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B37_02761	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B37_02763	COG0457	Tetratricopeptide repeat
B37_02765	COG5578	integral membrane protein
B37_02766	COG0673	inositol 2-dehydrogenase activity
B37_02767	COG1653	transport
B37_02768	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B37_02769	COG4209	transmembrane transport
B37_02770	COG2207	Transcriptional regulator
B37_02771	COG1653	transport
B37_02772	COG0395	ABC-type sugar transport system, permease component
B37_02773	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B37_02774	COG1073	alpha beta
B37_02776	COG0583	DNA-binding transcription factor activity
B37_02777	COG0346	lactoylglutathione lyase activity
B37_02778	COG0495	leucyl-tRNA aminoacylation
B37_02780	COG2814	Major facilitator Superfamily
B37_02782	COG2433	Pfam Transposase IS66
B37_02783	COG0577	efflux transmembrane transporter activity
B37_02784	COG1136	(ABC) transporter
B37_02786	COG1131	(ABC) transporter
B37_02787	COG1725	Transcriptional regulator
B37_02790	COG1242	4 iron, 4 sulfur cluster binding
B37_02791	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B37_02792	COG1301	dicarboxylic acid transport
B37_02794	COG2267	carboxylic ester hydrolase activity
B37_02795	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B37_02796	COG0671	phosphoesterase, PA-phosphatase related
B37_02797	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B37_02797	COG0438	transferase activity, transferring glycosyl groups
B37_02798	COG0367	asparagine synthase
B37_02799	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B37_02800	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B37_02801	COG1301	dicarboxylic acid transport
B37_02803	COG1506	peptidase
B37_02804	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B37_02805	COG1116	anion transmembrane transporter activity
B37_02806	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B37_02807	COG0494	nUDIX hydrolase
B37_02809	COG4824	toxin secretion phage lysis holin
B37_02810	COG0783	Belongs to the Dps family
B37_02813	COG1854	S-ribosylhomocysteine lyase activity
B37_02814	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B37_02815	COG0288	reversible hydration of carbon dioxide
B37_02816	COG0523	cobalamin synthesis protein
B37_02817	COG0803	Belongs to the bacterial solute-binding protein 9 family
B37_02818	COG0254	rRNA binding
B37_02819	COG1271	oxidase subunit
B37_02820	COG1294	oxidase, subunit
B37_02823	COG4948	Mandelate Racemase Muconate Lactonizing
B37_02824	COG0318	PFAM AMP-dependent synthetase and ligase
B37_02825	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B37_02826	COG0596	Alpha beta hydrolase
B37_02827	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B37_02828	COG1169	isochorismate synthase
B37_02829	COG1575	Belongs to the MenA family. Type 1 subfamily
B37_02830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B37_02831	COG0058	SHG alpha-glucan phosphorylase activity
B37_02832	COG0058	SHG alpha-glucan phosphorylase activity
B37_02833	COG0297	glycogen (starch) synthase activity
B37_02834	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B37_02835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B37_02836	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B37_02861	COG1609	Transcriptional regulator
B37_02862	COG3859	Proton-coupled thiamine transporter YuaJ
B37_02863	COG3764	Sortase (surface protein transpeptidase)
B37_02866	COG0457	Tetratricopeptide repeat
B37_02868	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B37_02869	COG0569	domain protein
B37_02870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B37_02872	COG2318	DinB family
B37_02874	COG1454	alcohol dehydrogenase
B37_02876	COG1510	regulation of RNA biosynthetic process
B37_02878	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B37_02879	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B37_02880	COG2140	Oxalate decarboxylase
B37_02892	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
B37_02895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B37_02896	COG0726	polysaccharide deacetylase
B37_02897	COG1408	metallophosphoesterase
B37_02898	COG1968	undecaprenyl-diphosphatase activity
B37_02899	COG0628	permease
B37_02900	COG0673	inositol 2-dehydrogenase activity
B37_02901	COG0693	protein deglycase activity
B37_02902	COG0840	transmembrane signaling receptor activity
B37_02903	COG0840	transmembrane signaling receptor activity
B37_02904	COG0840	transmembrane signaling receptor activity
B37_02905	COG0840	transmembrane signaling receptor activity
B37_02907	COG2070	2-Nitropropane dioxygenase
B37_02908	COG0432	Pfam Uncharacterised protein family UPF0047
B37_02909	COG0366	Alpha amylase catalytic
B37_02912	COG5297	Belongs to the glycosyl hydrolase family 6
B37_02913	COG1253	flavin adenine dinucleotide binding
B37_02914	COG2738	Putative neutral zinc metallopeptidase
B37_02917	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B37_02919	COG2323	membrane
B37_02920	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B37_02929	COG5444	nuclease activity
B37_02937	COG5434	Belongs to the glycosyl hydrolase 28 family
B37_02938	COG1705	Flagellar rod assembly protein muramidase FlgJ
B37_02940	COG5280	Phage tail tape measure protein TP901
B37_02940	COG3953	SLT domain
B37_02953	COG1802	Transcriptional regulator
B37_02953	COG4626	Terminase
B37_02977	COG0166	Belongs to the GPI family
B37_02978	COG1979	alcohol dehydrogenase
B37_02979	COG2155	Conserved Protein
B37_02980	COG1098	S1 RNA binding domain
B37_02981	COG0436	Aminotransferase
B37_02982	COG1522	sequence-specific DNA binding
B37_02983	COG2267	carboxylic ester hydrolase activity
B37_02986	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B37_02989	COG5018	Exonuclease
B37_02990	COG2814	Major facilitator Superfamily
B37_02991	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B37_02992	COG3011	Protein conserved in bacteria
B37_02994	COG3290	protein histidine kinase activity
B37_02995	COG4565	transcriptional regulatory protein
B37_02996	COG1183	phosphatidylcholine synthase activity
B37_02997	COG0586	Pfam SNARE associated Golgi protein
B37_02998	COG0688	phosphatidylethanolamine metabolic process
B37_02999	COG3493	citrate carrier protein
B37_03001	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B37_03001	COG2111	Na H antiporter
B37_03002	COG2111	Na H antiporter
B37_03003	COG1006	Multisubunit Na H antiporter MnhC subunit
B37_03004	COG0651	ATP synthesis coupled electron transport
B37_03005	COG1863	multisubunit Na H antiporter MnhE subunit
B37_03006	COG2212	antiporter activity
B37_03007	COG1320	monovalent cation:proton antiporter activity
B37_03008	COG2050	protein possibly involved in aromatic compounds catabolism
B37_03009	COG2197	response regulator
B37_03010	COG4585	Histidine kinase
B37_03016	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B37_03017	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B37_03018	COG1335	isochorismatase
B37_03019	COG5506	Protein of unknown function (DUF1694)
B37_03022	COG0628	permease
B37_03023	COG1959	2 iron, 2 sulfur cluster binding
B37_03026	COG1418	mRNA catabolic process
B37_03027	COG1028	Short-chain dehydrogenase reductase Sdr
B37_03029	COG1511	domain protein
B37_03030	COG1674	ftsk spoiiie
B37_03030	COG0433	COG0433 Predicted ATPase
B37_03031	COG4499	WXG100 protein secretion system (Wss), protein YukC
B37_03032	COG5417	Belongs to the EsaB family
B37_03033	COG4842	Belongs to the WXG100 family
B37_03034	COG1115	amino acid carrier protein
B37_03035	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B37_03035	COG2508	Transcriptional regulator
B37_03036	COG0686	Belongs to the AlaDH PNT family
B37_03038	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B37_03039	COG1268	BioY protein
B37_03040	COG2056	Na+-H+ antiporter family
B37_03041	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B37_03042	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B37_03043	COG3584	3D domain protein
B37_03045	COG1252	NADH dehydrogenase
B37_03046	COG0492	ferredoxin-NADP+ reductase activity
B37_03049	COG0456	acetyltransferase
B37_03050	COG0316	Belongs to the HesB IscA family
B37_03051	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B37_03052	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B37_03053	COG4844	belongs to the
B37_03054	COG1252	NADH dehydrogenase
B37_03055	COG5646	InterPro IPR014922
B37_03057	COG0457	Tetratricopeptide repeat
B37_03058	COG3479	Phenolic acid decarboxylase
B37_03060	COG4837	Protein of unknown function (DUF1462)
B37_03061	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B37_03062	COG0823	Involved in the tonB-independent uptake of proteins
B37_03062	COG1506	peptidase
B37_03062	COG4946	Tricorn protease homolog
B37_03063	COG0083	homoserine kinase activity
B37_03064	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B37_03065	COG0460	homoserine dehydrogenase
B37_03067	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B37_03068	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B37_03069	COG0647	UMP catabolic process
B37_03070	COG2445	Protein of unknown function DUF86
B37_03071	COG4470	Protein conserved in bacteria
B37_03074	COG0739	heme binding
B37_03076	COG0733	neurotransmitter:sodium symporter activity
B37_03078	COG3377	Domain of unknown function (DUF1805)
B37_03079	COG0737	Belongs to the 5'-nucleotidase family
B37_03080	COG0730	response to heat
B37_03081	COG1801	Protein of unknown function DUF72
B37_03083	COG3226	Transcriptional regulator
B37_03085	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B37_03086	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B37_03087	COG2508	Transcriptional regulator
B37_03088	COG2814	Major facilitator Superfamily
B37_03089	COG1288	antiporter activity
B37_03090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B37_03091	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B37_03092	COG2356	endonuclease I
B37_03094	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B37_03098	COG0457	Tetratricopeptide repeat
B37_03099	COG0719	Fe-S assembly protein
B37_03100	COG0822	iron-sulfur transferase activity
B37_03101	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B37_03102	COG0719	Fe-S assembly protein
B37_03103	COG0396	ATPase activity
B37_03105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B37_03106	COG1464	Belongs to the NlpA lipoprotein family
B37_03107	COG2011	ABC-type metal ion transport system permease component
B37_03108	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B37_03110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_03111	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B37_03113	COG0509	glycine decarboxylation via glycine cleavage system
B37_03114	COG1393	Belongs to the ArsC family
B37_03115	COG1960	acyl-CoA dehydrogenase activity
B37_03116	COG0183	Belongs to the thiolase family
B37_03117	COG1024	Enoyl-CoA hydratase
B37_03117	COG1250	3-hydroxyacyl-CoA dehydrogenase
B37_03120	COG5577	PFAM Coat F domain
B37_03123	COG1120	ATPase activity
B37_03124	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_03125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_03126	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_03129	COG1686	Belongs to the peptidase S11 family
B37_03130	COG1028	Short-chain dehydrogenase reductase Sdr
B37_03131	COG0783	Belongs to the Dps family
B37_03132	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B37_03133	COG0745	RESPONSE REGULATOR receiver
B37_03134	COG2205	protein histidine kinase activity
B37_03134	COG2770	Histidine kinase
B37_03136	COG1309	transcriptional regulator
B37_03137	COG0114	fumarate hydratase activity
B37_03139	COG0697	spore germination
B37_03140	COG0814	amino acid
B37_03143	COG2197	response regulator
B37_03144	COG4585	Histidine kinase
B37_03145	COG4758	membrane
B37_03147	COG1842	Phage shock protein A
B37_03148	COG4758	membrane
B37_03149	COG4677	pectinesterase activity
B37_03150	COG2096	Adenosyltransferase
B37_03151	COG1028	Short-chain dehydrogenase reductase Sdr
B37_03152	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B37_03153	COG1454	alcohol dehydrogenase
B37_03154	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B37_03155	COG1120	ATPase activity
B37_03156	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_03157	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_03158	COG1802	Transcriptional regulator
B37_03159	COG1028	Short-chain dehydrogenase reductase Sdr
B37_03160	COG2258	MOSC domain
B37_03161	COG0583	DNA-binding transcription factor activity
B37_03163	COG2721	sulfolactate sulfo-lyase activity
B37_03164	COG0246	Mannitol dehydrogenase
B37_03165	COG1609	Transcriptional regulator
B37_03166	COG2211	Major facilitator Superfamily
B37_03167	COG1904	glucuronate isomerase
B37_03168	COG2205	protein histidine kinase activity
B37_03169	COG0745	RESPONSE REGULATOR receiver
B37_03170	COG1120	ATPase activity
B37_03171	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_03172	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_03173	COG0531	amino acid
B37_03174	COG1988	membrane-bound metal-dependent
B37_03175	COG1368	sulfuric ester hydrolase activity
B37_03176	COG2814	Major facilitator Superfamily
B37_03177	COG0656	L-ascorbic acid biosynthetic process
B37_03178	COG1940	carbohydrate kinase activity
B37_03179	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B37_03181	COG3973	AAA domain
B37_03182	COG2860	membrane
B37_03183	COG0456	acetyltransferase
B37_03183	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B37_03185	COG0456	acetyltransferase
B37_03186	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B37_03187	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B37_03188	COG2217	Heavy metal translocating P-type atpase
B37_03189	COG1653	transport
B37_03190	COG1175	transmembrane transport
B37_03191	COG0395	ABC-type sugar transport system, permease component
B37_03192	COG1501	Belongs to the glycosyl hydrolase 31 family
B37_03193	COG1472	Belongs to the glycosyl hydrolase 3 family
B37_03194	COG1121	(ABC) transporter
B37_03195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B37_03196	COG0803	Belongs to the bacterial solute-binding protein 9 family
B37_03201	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_03201	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B37_03201	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_03205	COG2217	Heavy metal translocating P-type atpase
B37_03206	COG2608	mercury ion transmembrane transporter activity
B37_03207	COG1937	Protein conserved in bacteria
B37_03208	COG0693	protein deglycase activity
B37_03209	COG1349	DNA-binding transcription factor activity
B37_03210	COG1070	Carbohydrate kinase
B37_03211	COG4952	isomerase
B37_03213	COG3347	Dehydrogenase
B37_03213	COG1028	Short-chain dehydrogenase reductase Sdr
B37_03214	COG2814	Major facilitator Superfamily
B37_03216	COG2814	Major facilitator Superfamily
B37_03218	COG2124	cytochrome p450
B37_03220	COG1846	Transcriptional regulator
B37_03222	COG0154	amidase activity
B37_03223	COG0673	inositol 2-dehydrogenase activity
B37_03224	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B37_03228	COG1191	sigma factor activity
B37_03230	COG2140	Oxalate decarboxylase
B37_03237	COG5444	nuclease activity
B37_03241	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B37_03242	COG0557	exoribonuclease II activity
B37_03243	COG1647	Serine aminopeptidase, S33
B37_03244	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B37_03245	COG2002	toxin-antitoxin pair type II binding
B37_03246	COG1476	TRANSCRIPTIONal
B37_03247	COG1396	sequence-specific DNA binding
B37_03248	COG1396	sequence-specific DNA binding
B37_03249	COG1174	glycine betaine transport
B37_03250	COG1732	Glycine betaine
B37_03251	COG1174	glycine betaine transport
B37_03252	COG1125	glycine betaine transport
B37_03252	COG0517	IMP dehydrogenase activity
B37_03253	COG1510	regulation of RNA biosynthetic process
B37_03254	COG2095	MarC family integral membrane protein
B37_03255	COG3064	Membrane
B37_03256	COG4640	response to antibiotic
B37_03258	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_03260	COG0693	protein deglycase activity
B37_03261	COG0148	phosphopyruvate hydratase activity
B37_03262	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B37_03263	COG0149	triose-phosphate isomerase activity
B37_03264	COG0126	phosphoglycerate kinase activity
B37_03265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B37_03266	COG2390	Transcriptional regulator
B37_03267	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B37_03268	COG1113	amino acid transport
B37_03270	COG1131	(ABC) transporter
B37_03272	COG1556	Lactate utilization protein
B37_03273	COG1139	Iron-sulfur cluster binding protein
B37_03274	COG0247	lactate metabolic process
B37_03275	COG2186	Transcriptional regulator
B37_03276	COG1620	l-lactate permease
B37_03277	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B37_03279	COG5039	Polysaccharide pyruvyl transferase
B37_03280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B37_03281	COG0110	maltose O-acetyltransferase activity
B37_03282	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B37_03283	COG2244	polysaccharide biosynthetic process
B37_03284	COG1216	Glycosyl transferase, family 2
B37_03285	COG5039	Polysaccharide pyruvyl transferase
B37_03286	COG1216	Glycosyl transferase, family 2
B37_03288	COG0438	transferase activity, transferring glycosyl groups
B37_03289	COG1215	transferase activity, transferring glycosyl groups
B37_03290	COG0438	transferase activity, transferring glycosyl groups
B37_03291	COG1086	Polysaccharide biosynthesis protein
B37_03292	COG0489	protein tyrosine kinase activity
B37_03293	COG3944	biosynthesis protein
B37_03294	COG1396	sequence-specific DNA binding
B37_03295	COG2249	NAD(P)H dehydrogenase (quinone) activity
B37_03296	COG2271	Major facilitator Superfamily
B37_03298	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B37_03301	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B37_03303	COG1733	regulation of RNA biosynthetic process
B37_03304	COG1902	pentaerythritol trinitrate reductase activity
B37_03305	COG1621	beta-fructofuranosidase activity
B37_03306	COG1621	beta-fructofuranosidase activity
B37_03309	COG0740	serine-type endopeptidase activity
B37_03310	COG1611	Belongs to the LOG family
B37_03311	COG1694	Mazg nucleotide pyrophosphohydrolase
B37_03312	COG1078	dGTPase activity
B37_03313	COG0659	secondary active sulfate transmembrane transporter activity
B37_03314	COG0288	reversible hydration of carbon dioxide
B37_03315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B37_03316	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B37_03317	COG0640	Transcriptional regulator
B37_03319	COG2732	(Barnase) inhibitor
B37_03320	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B37_03321	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_03322	COG1481	regulation of sporulation
B37_03323	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B37_03324	COG1660	Displays ATPase and GTPase activities
B37_03325	COG1051	belongs to the nudix hydrolase family
B37_03326	COG0492	ferredoxin-NADP+ reductase activity
B37_03327	COG0457	Tetratricopeptide repeat
B37_03328	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B37_03329	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B37_03329	COG0140	phosphoribosyl-ATP diphosphatase activity
B37_03330	COG0107	imidazoleglycerol-phosphate synthase activity
B37_03331	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B37_03332	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B37_03333	COG0131	Imidazoleglycerol-phosphate dehydratase
B37_03334	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B37_03335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B37_03336	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B37_03337	COG4990	cell redox homeostasis
B37_03338	COG5297	Belongs to the glycosyl hydrolase family 6
B37_03339	COG0110	maltose O-acetyltransferase activity
B37_03340	COG0546	phosphoglycolate phosphatase activity
B37_03341	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B37_03342	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B37_03343	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B37_03344	COG1846	Transcriptional regulator
B37_03345	COG2814	Major facilitator Superfamily
B37_03346	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B37_03347	COG1950	PFAM Membrane protein of
B37_03348	COG1983	PspC domain protein
B37_03349	COG3595	metallopeptidase activity
B37_03353	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B37_03354	COG0556	nucleotide-excision repair
B37_03355	COG4897	Protein conserved in bacteria
B37_03357	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B37_03359	COG3409	Peptidoglycan-binding domain 1 protein
B37_03359	COG0793	Belongs to the peptidase S41A family
B37_03360	COG0473	3-isopropylmalate dehydrogenase activity
B37_03361	COG0791	NLP P60 protein
B37_03361	COG3883	PFAM NLP P60 protein
B37_03362	COG2177	Part of the ABC transporter FtsEX involved in
B37_03363	COG2884	Cell division ATP-binding protein ftsE
B37_03364	COG2010	Cytochrome c
B37_03365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_03366	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B37_03367	COG0653	protein targeting
B37_03368	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B37_03371	COG1516	flagellar protein fliS
B37_03372	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B37_03373	COG1334	flagellar protein FlaG
B37_03374	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B37_03375	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B37_03376	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B37_03378	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B37_03379	COG1256	bacterial-type flagellum assembly
B37_03379	COG4786	Flagellar basal body rod
B37_03380	COG3418	PFAM FlgN family protein
B37_03381	COG2747	anti-sigma28 factor FlgM
B37_03384	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B37_03385	COG1307	EDD domain protein, DegV family
B37_03386	COG2197	response regulator
B37_03387	COG4585	Histidine kinase
B37_03388	COG1739	Uncharacterized protein family UPF0029
B37_03389	COG1316	TRANSCRIPTIONal
B37_03391	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B37_03392	COG0438	transferase activity, transferring glycosyl groups
B37_03393	COG1215	transferase activity, transferring glycosyl groups
B37_03394	COG3206	protein involved in exopolysaccharide biosynthesis
B37_03395	COG3307	-O-antigen
B37_03396	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B37_03397	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B37_03398	COG0438	transferase activity, transferring glycosyl groups
B37_03398	COG0297	glycogen (starch) synthase activity
B37_03399	COG2244	polysaccharide biosynthetic process
B37_03401	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_03401	COG2247	cell wall binding repeat
B37_03402	COG2385	sporulation resulting in formation of a cellular spore
B37_03402	COG2247	cell wall binding repeat
B37_03404	COG1316	TRANSCRIPTIONal
B37_03405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B37_03406	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B37_03407	COG1134	teichoic acid transport
B37_03408	COG1682	transport, permease protein
B37_03410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B37_03410	COG0463	Glycosyl transferase, family 2
B37_03411	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B37_03412	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B37_03413	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B37_03414	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B37_03415	COG4193	domain, Protein
B37_03416	COG1482	cell wall glycoprotein biosynthetic process
B37_03420	COG0800	Aldolase
B37_03421	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B37_03422	COG1609	Transcriptional regulator
B37_03423	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B37_03424	COG1028	Short-chain dehydrogenase reductase Sdr
B37_03425	COG1063	alcohol dehydrogenase
B37_03427	COG2814	Major facilitator Superfamily
B37_03428	COG1316	TRANSCRIPTIONal
B37_03429	COG0561	phosphatase activity
B37_03430	COG0791	NLP P60 protein
B37_03432	COG2843	Capsule synthesis protein
B37_03434	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B37_03435	COG1609	Transcriptional regulator
B37_03436	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B37_03437	COG1869	D-ribose catabolic process
B37_03438	COG1129	ABC transporter
B37_03439	COG1172	Belongs to the binding-protein-dependent transport system permease family
B37_03440	COG1879	ABC-type sugar transport system periplasmic component
B37_03441	COG3527	Alpha-acetolactate decarboxylase
B37_03442	COG0028	Belongs to the TPP enzyme family
B37_03443	COG0583	DNA-binding transcription factor activity
B37_03445	COG2801	Transposase and inactivated derivatives
B37_03446	COG0405	Gamma-glutamyltransferase
B37_03447	COG1522	sequence-specific DNA binding
B37_03448	COG2059	Chromate
B37_03449	COG2059	Chromate
B37_03450	COG4464	protein tyrosine phosphatase activity
B37_03451	COG3944	biosynthesis protein
B37_03453	COG4715	Zinc finger, swim domain protein
B37_03454	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B37_03456	COG0561	phosphatase activity
B37_03457	COG1349	DNA-binding transcription factor activity
B37_03459	COG1028	Short-chain dehydrogenase reductase Sdr
B37_03461	COG3732	PTS system glucitol sorbitol-specific
B37_03465	COG0629	single-stranded DNA binding
B37_03468	COG1970	mechanosensitive ion channel activity
B37_03469	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B37_03470	COG4786	Flagellar basal body rod
B37_03471	COG4786	Flagellar basal body rod
B37_03472	COG1077	Cell shape determining protein MreB Mrl
B37_03473	COG1609	Transcriptional regulator
B37_03474	COG1846	Transcriptional regulator
B37_03475	COG2814	Major facilitator Superfamily
B37_03476	COG0671	phosphoesterase, PA-phosphatase related
B37_03477	COG1227	inorganic diphosphatase activity
B37_03478	COG3546	catalase activity
B37_03479	COG3361	conserved protein (COG2071)
B37_03480	COG0517	IMP dehydrogenase activity
B37_03481	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B37_03482	COG0598	Magnesium transport protein CorA
B37_03483	COG1253	flavin adenine dinucleotide binding
B37_03484	COG0004	ammonium transporteR
B37_03485	COG0347	Belongs to the P(II) protein family
B37_03486	COG0740	serine-type endopeptidase activity
B37_03488	COG0739	heme binding
B37_03489	COG1247	-acetyltransferase
B37_03491	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B37_03493	COG0477	Major facilitator Superfamily
B37_03494	COG3251	PFAM MbtH domain protein
B37_03495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B37_03496	COG3433	isochorismatase activity
B37_03496	COG1535	isochorismatase
B37_03497	COG1021	2,3-dihydroxybenzoate-AMP ligase
B37_03498	COG1169	isochorismate synthase
B37_03499	COG1028	Short-chain dehydrogenase reductase Sdr
B37_03500	COG2819	hydrolase of the alpha beta superfamily
B37_03501	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_03502	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_03503	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_03504	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_03504	COG2207	Transcriptional regulator
B37_03506	COG2910	NAD(P)H-binding
B37_03507	COG1959	2 iron, 2 sulfur cluster binding
B37_03509	COG1994	Peptidase M50
B37_03510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B37_03511	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B37_03513	COG3383	formate dehydrogenase (NAD+) activity
B37_03514	COG2304	oxidoreductase activity
B37_03515	COG2304	oxidoreductase activity
B37_03516	COG2385	sporulation resulting in formation of a cellular spore
B37_03517	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B37_03519	COG4836	Membrane
B37_03520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B37_03521	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B37_03522	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B37_03523	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B37_03524	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B37_03525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B37_03526	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B37_03529	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B37_03530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B37_03531	COG4475	Protein of unknown function (DUF436)
B37_03532	COG0698	ribose 5-phosphate isomerase
B37_03533	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B37_03534	COG1971	Probably functions as a manganese efflux pump
B37_03535	COG0009	L-threonylcarbamoyladenylate synthase
B37_03536	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B37_03538	COG0738	Major facilitator superfamily
B37_03539	COG0673	inositol 2-dehydrogenase activity
B37_03540	COG0561	phosphatase activity
B37_03541	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B37_03542	COG1609	Transcriptional regulator
B37_03543	COG2890	protein-(glutamine-N5) methyltransferase activity
B37_03544	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B37_03545	COG0346	lactoylglutathione lyase activity
B37_03546	COG0789	Transcriptional regulator
B37_03547	COG0679	Auxin Efflux Carrier
B37_03548	COG0281	malic enzyme
B37_03549	COG1435	thymidine kinase activity
B37_03550	COG0254	rRNA binding
B37_03551	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B37_03552	COG1494	fructose-1,6-bisphosphatase
B37_03553	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B37_03554	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B37_03555	COG0191	fructose-bisphosphate aldolase activity
B37_03556	COG2204	response regulator
B37_03557	COG4821	SIS domain
B37_03559	COG2801	Transposase and inactivated derivatives
B37_03560	COG0504	CTP synthase activity
B37_03561	COG3343	RNA polymerase activity
B37_03562	COG1960	acyl-CoA dehydrogenase activity
B37_03563	COG1960	acyl-CoA dehydrogenase activity
B37_03564	COG1250	3-hydroxyacyl-CoA dehydrogenase
B37_03565	COG0183	Belongs to the thiolase family
B37_03566	COG2181	nitrate reductase activity
B37_03566	COG0247	lactate metabolic process
B37_03567	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B37_03569	COG0018	arginyl-trna synthetase
B37_03570	COG4506	Protein conserved in bacteria
B37_03571	COG0010	Belongs to the arginase family
B37_03572	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B37_03574	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B37_03576	COG1994	Peptidase M50
B37_03577	COG1942	4-Oxalocrotonate Tautomerase
B37_03579	COG3465	dGTPase activity
B37_03580	COG1078	dGTPase activity
B37_03581	COG4844	belongs to the
B37_03586	COG2814	Major facilitator Superfamily
B37_03591	COG1414	Transcriptional regulator
B37_03593	COG0280	phosphate acetyltransferase
B37_03596	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B37_03600	COG1131	(ABC) transporter
B37_03603	COG2363	Small membrane protein
B37_03604	COG2233	PERMEase
B37_03606	COG1012	belongs to the aldehyde dehydrogenase family
B37_03607	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B37_03608	COG1216	Glycosyl transferase, family 2
B37_03609	COG0351	phosphomethylpyrimidine kinase
B37_03611	COG1621	beta-fructofuranosidase activity
B37_03612	COG1263	PTS System
B37_03612	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_03613	COG3711	transcriptional antiterminator
B37_03615	COG1404	Belongs to the peptidase S8 family
B37_03617	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B37_03619	COG0778	Nitroreductase
B37_03620	COG1473	amidohydrolase
B37_03621	COG0772	Belongs to the SEDS family
B37_03622	COG0772	Belongs to the SEDS family
B37_03627	COG0456	acetyltransferase
B37_03635	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B37_03637	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B37_03638	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B37_03639	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B37_03643	COG0655	NAD(P)H dehydrogenase (quinone) activity
B37_03644	COG3162	membrane
B37_03645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_03646	COG1070	Carbohydrate kinase
B37_03647	COG2115	Belongs to the xylose isomerase family
B37_03649	COG0352	thiamine-phosphate diphosphorylase activity
B37_03650	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B37_03651	COG0583	DNA-binding transcription factor activity
B37_03654	COG1380	Effector of murein hydrolase LrgA
B37_03655	COG1346	cytolysis
B37_03657	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_03658	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B37_03659	COG0346	lactoylglutathione lyase activity
B37_03660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B37_03661	COG1442	glycosyl transferase family 8
B37_03663	COG4585	Histidine kinase
B37_03664	COG2197	response regulator
B37_03665	COG2409	Drug exporters of the RND superfamily
B37_03666	COG5522	Integral membrane protein (intg_mem_TP0381)
B37_03667	COG2271	Major facilitator Superfamily
B37_03668	COG4948	Mandelate Racemase Muconate Lactonizing
B37_03669	COG0800	Aldolase
B37_03670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B37_03672	COG2234	aminopeptidase activity
B37_03673	COG0477	Major facilitator Superfamily
B37_03675	COG2357	RelA SpoT domain protein
B37_03678	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B37_03679	COG1696	Membrane protein involved in D-alanine export
B37_03680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B37_03681	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B37_03682	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B37_03683	COG2814	Major facilitator Superfamily
B37_03684	COG1486	melibiose metabolic process
B37_03685	COG1447	Phosphotransferase system cellobiose-specific component IIA
B37_03686	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_03687	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_03688	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_03688	COG3711	transcriptional antiterminator
B37_03690	COG2094	Belongs to the DNA glycosylase MPG family
B37_03692	COG0372	Belongs to the citrate synthase family
B37_03693	COG2079	MmgE PrpD family protein
B37_03694	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B37_03697	COG1132	(ABC) transporter
B37_03698	COG2755	lipolytic protein G-D-S-L family
B37_03701	COG2814	Major facilitator Superfamily
B37_03702	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B37_03703	COG1131	(ABC) transporter
B37_03707	COG1595	DNA-templated transcription, initiation
B37_03708	COG2814	Major facilitator Superfamily
B37_03709	COG0753	catalase activity
B37_03710	COG0753	catalase activity
B37_03711	COG0735	belongs to the Fur family
B37_03713	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B37_03714	COG1131	(ABC) transporter
B37_03717	COG1131	(ABC) transporter
B37_03727	COG3866	Pectate lyase
B37_03728	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B37_03729	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B37_03730	COG4988	ABC transporter
B37_03731	COG1294	oxidase, subunit
B37_03732	COG1271	oxidase subunit
B37_03733	COG2116	formate transmembrane transporter activity
B37_03735	COG0281	malic enzyme
B37_03736	COG1757	Na H antiporter
B37_03737	COG1027	Aspartate ammonia-lyase
B37_03738	COG0252	asparaginase activity
B37_03739	COG1396	sequence-specific DNA binding
B37_03740	COG2706	6-phosphogluconolactonase activity
B37_03741	COG0745	RESPONSE REGULATOR receiver
B37_03742	COG2205	protein histidine kinase activity
B37_03743	COG1136	(ABC) transporter
B37_03744	COG0577	efflux transmembrane transporter activity
B37_03745	COG5294	Protein conserved in bacteria
B37_03748	COG0726	polysaccharide deacetylase
B37_03749	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B37_03750	COG1215	transferase activity, transferring glycosyl groups
B37_03752	COG2801	Transposase and inactivated derivatives
B37_03753	COG3493	citrate carrier protein
B37_03754	COG0584	glycerophosphoryl diester phosphodiesterase
B37_03757	COG1368	sulfuric ester hydrolase activity
B37_03759	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_03761	COG2235	arginine
B37_03762	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B37_03764	COG0549	Belongs to the carbamate kinase family
B37_03766	COG2723	6-phospho-beta-galactosidase activity
B37_03767	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_03769	COG1595	DNA-templated transcription, initiation
B37_03774	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B37_03775	COG2195	Cleaves the N-terminal amino acid of tripeptides
B37_03776	COG1621	beta-fructofuranosidase activity
B37_03777	COG2223	nitrite transmembrane transporter activity
B37_03778	COG1609	Transcriptional regulator
B37_03782	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B37_03783	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B37_03784	COG0463	Glycosyl transferase, family 2
B37_03785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B37_03790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B37_03791	COG0753	catalase activity
B37_03791	COG0693	protein deglycase activity
B37_03792	COG0693	protein deglycase activity
B37_03792	COG0753	catalase activity
B37_03794	COG2723	6-phospho-beta-galactosidase activity
B37_03795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_03795	COG2190	(PTS) system
B37_03795	COG1263	PTS System
B37_03796	COG3711	transcriptional antiterminator
B37_03797	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B37_03798	COG1122	ATPase activity
B37_03799	COG4721	ABC-type cobalt transport system, permease component
B37_03800	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B37_03802	COG2224	Isocitrate lyase
B37_03803	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B37_03805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B37_03806	COG0577	efflux transmembrane transporter activity
B37_03807	COG1136	(ABC) transporter
B37_03808	COG2205	protein histidine kinase activity
B37_03809	COG0745	RESPONSE REGULATOR receiver
B37_03810	COG2723	6-phospho-beta-galactosidase activity
B37_03811	COG1263	PTS System
B37_03811	COG2190	(PTS) system
B37_03811	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_03813	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B37_03816	COG3507	Belongs to the glycosyl hydrolase 43 family
B37_03822	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B37_03823	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B37_03824	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B37_03825	COG2390	Transcriptional regulator
B37_03827	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B37_03828	COG3706	GGDEF domain
B37_03829	COG5298	Protein conserved in bacteria
B37_03830	COG5298	Protein conserved in bacteria
B37_03831	COG1215	transferase activity, transferring glycosyl groups
B37_03833	COG3977	Valine--pyruvate aminotransferase
B37_03836	COG1181	Belongs to the D-alanine--D-alanine ligase family
B37_03838	COG0191	fructose-bisphosphate aldolase activity
B37_03839	COG1082	Xylose isomerase domain protein TIM barrel
B37_03840	COG1082	Xylose isomerase domain protein TIM barrel
B37_03841	COG0673	inositol 2-dehydrogenase activity
B37_03842	COG2814	Major facilitator Superfamily
B37_03843	COG1082	Xylose isomerase domain protein TIM barrel
B37_03844	COG3962	Belongs to the TPP enzyme family
B37_03845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B37_03846	COG3718	enzyme involved in inositol metabolism
B37_03847	COG1012	belongs to the aldehyde dehydrogenase family
B37_03848	COG1349	DNA-binding transcription factor activity
B37_03849	COG0667	Aldo Keto reductase
B37_03850	COG0584	glycerophosphoryl diester phosphodiesterase
B37_03851	COG2271	Major facilitator Superfamily
B37_03852	COG0326	Molecular chaperone. Has ATPase activity
B37_03853	COG0488	(ABC) transporter
B37_03854	COG0561	phosphatase activity
B37_03859	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B37_03864	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
B37_03865	COG0577	efflux transmembrane transporter activity
B37_03866	COG1136	(ABC) transporter
B37_03867	COG2205	protein histidine kinase activity
B37_03868	COG0745	RESPONSE REGULATOR receiver
B37_03870	COG5278	phosphoserine phosphatase activity
B37_03870	COG0840	transmembrane signaling receptor activity
B37_03871	COG1115	amino acid carrier protein
B37_03872	COG0686	Belongs to the AlaDH PNT family
B37_03873	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B37_03874	COG1874	Beta-galactosidase
B37_03875	COG3833	ABC-type maltose transport systems, permease component
B37_03876	COG1175	transmembrane transport
B37_03877	COG2182	Extracellular solute-binding protein
B37_03878	COG1609	Transcriptional regulator
B37_03880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B37_03881	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B37_03882	COG1940	carbohydrate kinase activity
B37_03887	COG1012	belongs to the aldehyde dehydrogenase family
B37_03887	COG1454	alcohol dehydrogenase
B37_03888	COG0450	alkyl hydroperoxide reductase
B37_03889	COG3634	alkyl hydroperoxide reductase activity
B37_03894	COG1131	(ABC) transporter
B37_03895	COG0842	Transport permease protein
B37_03896	COG4585	Histidine kinase
B37_03897	COG4585	Histidine kinase
B37_03898	COG2197	response regulator
B37_03904	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B37_03907	COG0456	acetyltransferase
B37_03910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B37_03911	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B37_03912	COG4853	Protein conserved in bacteria
B37_03913	COG4863	YycH protein
B37_03914	COG5002	protein histidine kinase activity
B37_03915	COG0745	RESPONSE REGULATOR receiver
B37_03920	COG1051	belongs to the nudix hydrolase family
B37_03921	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B37_03923	COG0305	Participates in initiation and elongation during chromosome replication
B37_03926	COG3093	addiction module antidote protein HigA
B37_03927	COG2807	transmembrane transport
B37_03928	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B37_03929	COG0363	glucosamine-6-phosphate deaminase activity
B37_03931	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B37_03932	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_03932	COG1263	PTS System
B37_03933	COG0359	binds to the 23S rRNA
B37_03934	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B37_03935	COG4241	membrane
B37_03936	COG5577	PFAM Coat F domain
B37_03937	COG0589	response to stress
B37_03938	COG0659	secondary active sulfate transmembrane transporter activity
B37_03939	COG2271	Major facilitator Superfamily
B37_03940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B37_03941	COG0629	single-stranded DNA binding
B37_03942	COG0360	Binds together with S18 to 16S ribosomal RNA
B37_03943	COG0012	GTP binding
B37_03944	COG4481	Protein conserved in bacteria
B37_03945	COG3949	Membrane
B37_03947	COG1475	DNA binding
B37_03948	COG1192	Involved in chromosome partitioning
B37_03949	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B37_03951	COG1475	DNA binding
B37_03952	COG0357	Ribosomal RNA small subunit methyltransferase G
B37_03953	COG0445	tRNA wobble uridine modification
B37_03954	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B37_03955	COG1847	R3H domain protein
B37_03956	COG0706	membrane insertase activity
B37_03957	COG0594	ribonuclease P activity
B37_03958	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B37_03959	COG0592	DNA-directed DNA polymerase activity
B37_03960	COG2501	S4 domain
B37_03961	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B37_03962	COG0187	DNA topoisomerase II activity
B37_03963	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B37_03970	COG0516	GMP reductase activity
B37_03970	COG0517	IMP dehydrogenase activity
B37_03971	COG1686	Belongs to the peptidase S11 family
B37_03972	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B37_03973	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B37_03974	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B37_03975	COG1929	Belongs to the glycerate kinase type-1 family
B37_03976	COG2610	gluconate transmembrane transporter activity
B37_03977	COG2610	gluconate transmembrane transporter activity
B37_03978	COG3835	regulator
B37_03981	COG1428	Deoxynucleoside kinase
B37_03982	COG1428	Deoxynucleoside kinase
B37_03983	COG3858	chitin binding
B37_03983	COG1388	LysM domain
B37_03984	COG1335	isochorismatase
B37_03985	COG0590	tRNA wobble adenosine to inosine editing
B37_03986	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B37_03987	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B37_03988	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B37_03997	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
B37_03998	COG3853	Toxic anion resistance protein (TelA)
B37_03999	COG1982	Orn Lys Arg decarboxylase major
B37_04000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B37_04001	COG3870	Protein conserved in bacteria
B37_04002	COG1728	Protein conserved in bacteria
B37_04003	COG0470	DNA polymerase III
B37_04004	COG1774	PSP1 C-terminal conserved region
B37_04005	COG4467	Involved in initiation control of chromosome replication
B37_04006	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B37_04007	COG2827	Endonuclease containing a URI domain
B37_04008	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B37_04009	COG2002	toxin-antitoxin pair type II binding
B37_04010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B37_04010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B37_04011	COG0084	hydrolase, TatD family'
B37_04012	COG3583	domain protein
B37_04012	COG3584	3D domain protein
B37_04013	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B37_04014	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B37_04016	COG4466	Protein conserved in bacteria
B37_04019	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B37_04020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B37_04021	COG0251	oxidation-reduction process
B37_04022	COG2088	sporulation resulting in formation of a cellular spore
B37_04023	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B37_04024	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B37_04025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B37_04026	COG0193	aminoacyl-tRNA hydrolase activity
B37_04028	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B37_04029	COG2002	toxin-antitoxin pair type II binding
B37_04030	COG2244	polysaccharide biosynthetic process
B37_04031	COG3956	TIGRFAM MazG family protein
B37_04032	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B37_04035	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B37_04036	COG1098	S1 RNA binding domain
B37_04039	COG2208	phosphoserine phosphatase activity
B37_04040	COG2304	oxidoreductase activity
B37_04041	COG0515	serine threonine protein kinase
B37_04042	COG0037	tRNA processing
B37_04044	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B37_04045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B37_04046	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B37_04047	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B37_04048	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B37_04049	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B37_04050	COG0512	Glutamine amidotransferase of anthranilate synthase
B37_04051	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B37_04052	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B37_04053	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B37_04054	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B37_04055	COG1396	sequence-specific DNA binding
B37_04056	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B37_04057	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B37_04073	COG4463	regulation of RNA biosynthetic process
B37_04074	COG3880	PFAM UvrB UvrC protein
B37_04075	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B37_04076	COG0542	response to heat
B37_04077	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B37_04078	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B37_04079	COG4956	integral membrane protein (PIN domain superfamily)
B37_04080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B37_04081	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B37_04082	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B37_04083	COG1045	serine acetyltransferase
B37_04084	COG0215	cysteine-tRNA ligase activity
B37_04085	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B37_04086	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B37_04087	COG3688	RNA-binding protein containing a PIN domain
B37_04090	COG0250	Participates in transcription elongation, termination and antitermination
B37_04091	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B37_04092	COG0081	regulation of translation
B37_04093	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B37_04094	COG0222	ribosome binding
B37_04095	COG2813	Specifically methylates the guanine in position
B37_04096	COG0085	RNA polymerase activity
B37_04097	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B37_04098	COG1358	cellular component organization or biogenesis
B37_04099	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B37_04100	COG0049	tRNA binding
B37_04101	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B37_04102	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B37_04103	COG0051	transcription antitermination factor activity, RNA binding
B37_04104	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B37_04105	COG0088	Forms part of the polypeptide exit tunnel
B37_04106	COG0089	rRNA binding
B37_04107	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B37_04108	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B37_04109	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B37_04110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B37_04111	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B37_04112	COG0255	Belongs to the universal ribosomal protein uL29 family
B37_04113	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B37_04114	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B37_04115	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B37_04116	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B37_04117	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B37_04118	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B37_04119	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B37_04120	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B37_04121	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B37_04122	COG1841	ribosomal large subunit assembly
B37_04123	COG0200	Binds to the 23S rRNA
B37_04124	COG0201	protein transport
B37_04125	COG0563	adenylate kinase activity
B37_04126	COG0024	Methionine aminopeptidase
B37_04127	COG2163	COG2163 Ribosomal protein L14E L6E L27E
B37_04128	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B37_04129	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B37_04130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B37_04131	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B37_04132	COG0202	RNA polymerase activity
B37_04133	COG0203	ribosomal protein L17
B37_04134	COG1122	ATPase activity
B37_04135	COG1122	ATPase activity
B37_04136	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B37_04137	COG0101	tRNA pseudouridine synthase activity
B37_04138	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B37_04139	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B37_04140	COG2318	DinB family
B37_04142	COG0860	N-Acetylmuramoyl-L-alanine amidase
B37_04143	COG0489	protein tyrosine kinase activity
B37_04145	COG2194	sulfuric ester hydrolase activity
B37_04146	COG0726	polysaccharide deacetylase
B37_04153	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B37_04155	COG0385	Bile acid
B37_04158	COG3876	Protein conserved in bacteria
B37_04159	COG1472	Belongs to the glycosyl hydrolase 3 family
B37_04160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B37_04161	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_04161	COG1263	PTS System
B37_04162	COG1737	Transcriptional regulator
B37_04163	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B37_04164	COG1683	Conserved Protein
B37_04171	COG1595	DNA-templated transcription, initiation
B37_04172	COG5662	AntiSigma factor
B37_04173	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B37_04174	COG4856	YbbR-like protein
B37_04175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B37_04176	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B37_04179	COG1131	(ABC) transporter
B37_04180	COG1725	Transcriptional regulator
B37_04181	COG0640	Transcriptional regulator
B37_04182	COG2814	Major facilitator Superfamily
B37_04184	COG1132	(ABC) transporter
B37_04185	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B37_04190	COG1011	Hydrolase
B37_04191	COG1113	amino acid transport
B37_04192	COG2851	Citrate transporter
B37_04193	COG3181	Tripartite tricarboxylate transporter family receptor
B37_04194	COG4565	transcriptional regulatory protein
B37_04195	COG3290	protein histidine kinase activity
B37_04198	COG2211	Major facilitator Superfamily
B37_04202	COG1331	Highly conserved protein containing a thioredoxin domain
B37_04203	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
B37_04204	COG1331	Highly conserved protein containing a thioredoxin domain
B37_04205	COG0477	Major facilitator Superfamily
B37_04209	COG1283	sodium-dependent phosphate transmembrane transporter activity
B37_04210	COG4682	membrane
B37_04215	COG0697	spore germination
B37_04216	COG2207	Transcriptional regulator
B37_04216	COG1917	Cupin 2, conserved barrel domain protein
B37_04220	COG0371	Dehydrogenase
B37_04221	COG0840	transmembrane signaling receptor activity
B37_04222	COG4213	ABC transporter substrate-binding protein
B37_04225	COG4257	antibiotic catabolic process
B37_04227	COG0833	amino acid
B37_04228	COG2040	homocysteine
B37_04230	COG2190	(PTS) system
B37_04230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B37_04230	COG1263	PTS System
B37_04231	COG0789	Transcriptional regulator
B37_04232	COG2323	membrane
B37_04234	COG2205	protein histidine kinase activity
B37_04235	COG1115	amino acid carrier protein
B37_04236	COG2066	Belongs to the glutaminase family
B37_04237	COG4191	Histidine kinase
B37_04238	COG0784	Response regulator, receiver
B37_04243	COG3540	Alkaline phosphatase
B37_04244	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B37_04245	COG0805	protein transport
B37_04246	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B37_04247	COG1012	belongs to the aldehyde dehydrogenase family
B37_04248	COG2271	Major facilitator Superfamily
B37_04249	COG4948	Mandelate Racemase Muconate Lactonizing
B37_04250	COG2186	Transcriptional regulator
B37_04251	COG2721	sulfolactate sulfo-lyase activity
B37_04252	COG0745	RESPONSE REGULATOR receiver
B37_04253	COG2205	protein histidine kinase activity
B37_04254	COG1131	(ABC) transporter
B37_04259	COG3173	Aminoglycoside phosphotransferase
B37_04260	COG1846	Transcriptional regulator
B37_04261	COG0318	PFAM AMP-dependent synthetase and ligase
B37_04265	COG0789	Transcriptional regulator
B37_04270	COG0697	spore germination
B37_04271	COG1714	RDD family
B37_04272	COG1405	negative regulation of cell septum assembly
B37_04272	COG3012	SEC-C Motif Domain Protein
B37_04278	COG0583	DNA-binding transcription factor activity
B37_04279	COG1942	4-Oxalocrotonate Tautomerase
B37_04280	COG1028	Short-chain dehydrogenase reductase Sdr
B37_04283	COG1288	antiporter activity
B37_04285	COG0456	acetyltransferase
B37_04287	COG1164	Oligoendopeptidase f
B37_04288	COG2261	transglycosylase associated protein
B37_04290	COG0247	lactate metabolic process
B37_04291	COG0277	FAD linked oxidase domain protein
B37_04292	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_04293	COG1447	Phosphotransferase system cellobiose-specific component IIA
B37_04294	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B37_04295	COG1486	melibiose metabolic process
B37_04297	COG3394	polysaccharide catabolic process
B37_04301	COG3591	Belongs to the peptidase S1B family
B37_04302	COG1028	Short-chain dehydrogenase reductase Sdr
B37_04304	COG1595	DNA-templated transcription, initiation
B37_04306	COG3773	Cell wall hydrolase
B37_04307	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B37_04308	COG3883	PFAM NLP P60 protein
B37_04308	COG0791	NLP P60 protein
B37_04310	COG1131	(ABC) transporter
B37_04311	COG1309	transcriptional regulator
B37_04315	COG2310	stress, protein
B37_04316	COG2310	stress, protein
B37_04317	COG2310	stress, protein
B37_04318	COG0861	Integral membrane protein TerC family
B37_04322	COG3853	Toxic anion resistance protein (TelA)
B37_04323	COG0785	Cytochrome C biogenesis protein
B37_04325	COG0789	Transcriptional regulator
B37_04326	COG2223	nitrite transmembrane transporter activity
B37_04327	COG0039	L-malate dehydrogenase activity
B37_04328	COG1620	l-lactate permease
B37_04329	COG1280	lysine exporter protein (LysE YggA)
B37_04330	COG1113	amino acid transport
B37_04331	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B37_04332	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B37_04333	COG3541	Predicted nucleotidyltransferase
B37_04334	COG0506	proline dehydrogenase activity
B37_04335	COG1012	belongs to the aldehyde dehydrogenase family
B37_04336	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B37_04337	COG2508	Transcriptional regulator
B37_04338	COG3689	TIGRFAM TIGR03943 family protein
B37_04339	COG0701	Predicted permease
B37_04340	COG3458	cephalosporin-C deacetylase activity
B37_04344	COG0765	amino acid transport
B37_04345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B37_04346	COG2249	NAD(P)H dehydrogenase (quinone) activity
B37_04348	COG2723	6-phospho-beta-galactosidase activity
B37_04350	COG3209	COG3209 Rhs family protein
B37_04351	COG0515	serine threonine protein kinase
B37_04351	COG3266	domain, Protein
B37_04352	COG3290	protein histidine kinase activity
B37_04352	COG0840	transmembrane signaling receptor activity
B37_04353	COG3290	protein histidine kinase activity
B37_04353	COG0840	transmembrane signaling receptor activity
B37_04354	COG5444	nuclease activity
B37_04359	COG1176	ABC-type spermidine putrescine transport system, permease component I
B37_04361	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B37_04362	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B37_04363	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B37_04364	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B37_04365	COG0697	spore germination
B37_04366	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B37_04368	COG2819	hydrolase of the alpha beta superfamily
B37_04370	COG2364	Membrane
B37_04372	COG1131	(ABC) transporter
B37_04378	COG1126	abc transporter atp-binding protein
B37_04379	COG0765	amino acid transport
B37_04380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B37_04381	COG3829	transcription factor binding
B37_04382	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B37_04383	COG0833	amino acid
B37_04384	COG0010	Belongs to the arginase family
B37_04385	COG0583	DNA-binding transcription factor activity
B37_04386	COG0163	prenyltransferase activity
B37_04387	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B37_04397	COG5444	nuclease activity
B37_04401	COG2972	Histidine kinase
B37_04402	COG4753	response regulator
B37_04402	COG2207	Transcriptional regulator
B37_04403	COG4213	ABC transporter substrate-binding protein
B37_04405	COG4214	carbohydrate transport
B37_04406	COG2271	Major facilitator Superfamily
B37_04407	COG0456	acetyltransferase
B37_04407	COG1846	Transcriptional regulator
B37_04408	COG1874	Beta-galactosidase
B37_04409	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
B37_04410	COG3104	oligopeptide transport
B37_04411	COG5434	Belongs to the glycosyl hydrolase 28 family
B37_04413	COG0697	spore germination
B37_04415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B37_04416	COG0789	Transcriptional regulator
B37_04417	COG1136	(ABC) transporter
B37_04418	COG0577	efflux transmembrane transporter activity
B37_04419	COG0745	RESPONSE REGULATOR receiver
B37_04420	COG5002	protein histidine kinase activity
B37_04420	COG3850	Histidine kinase
B37_04421	COG0840	transmembrane signaling receptor activity
B37_04421	COG3290	protein histidine kinase activity
B37_04422	COG0840	transmembrane signaling receptor activity
B37_04423	COG0527	aspartate kinase activity
B37_04424	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B37_04425	COG4605	iron ion homeostasis
B37_04426	COG4604	ABC transporter, ATP-binding protein
B37_04427	COG4607	ABC-type enterochelin transport system periplasmic component
B37_04428	COG2814	Major facilitator Superfamily
B37_04429	COG1309	transcriptional regulator
B37_04431	COG0778	Nitroreductase
B37_04432	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B37_04433	COG0640	Transcriptional regulator
B37_04434	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B37_04435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B37_04436	COG0531	amino acid
B37_04437	COG1012	belongs to the aldehyde dehydrogenase family
B37_04438	COG0697	spore germination
B37_04440	COG4549	nuclear export factor GLE1
B37_04441	COG2372	response to copper ion
B37_04441	COG1276	copper resistance
B37_04442	COG1349	DNA-binding transcription factor activity
B37_04443	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B37_04444	COG0243	molybdopterin cofactor binding
B37_04445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B37_04446	COG2146	nitrite reductase [NAD(P)H] activity
B37_04447	COG1587	Uroporphyrinogen-III synthase
B37_04447	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B37_04448	COG1802	Transcriptional regulator
B37_04449	COG0471	metal ion transport
B37_04451	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_04454	COG3959	Transketolase, thiamine diphosphate binding domain
B37_04455	COG3958	Transketolase
B37_04456	COG0561	phosphatase activity
B37_04457	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B37_04458	COG1914	H( )-stimulated, divalent metal cation uptake system
B37_04459	COG4336	lyase activity
B37_04460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B37_04461	COG1984	allophanate hydrolase subunit 2
B37_04462	COG1414	Transcriptional regulator
B37_04463	COG2755	lipolytic protein G-D-S-L family
B37_04464	COG2213	PTS system mannitol-specific
B37_04465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B37_04466	COG0246	Mannitol dehydrogenase
B37_04467	COG3711	transcriptional antiterminator
B37_04468	COG1028	Short-chain dehydrogenase reductase Sdr
B37_04469	COG1917	Cupin 2, conserved barrel domain protein
B37_04471	COG3871	stress protein (general stress protein 26)
B37_04473	COG1316	TRANSCRIPTIONal
B37_04474	COG2814	Major facilitator Superfamily
B37_04476	COG1522	sequence-specific DNA binding
B37_04477	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B37_04477	COG0551	DNA topoisomerase type I activity
B37_04478	COG0531	amino acid
B37_04479	COG0531	amino acid
B37_04480	COG0028	Belongs to the TPP enzyme family
B37_04481	COG3397	chitin binding
B37_04483	COG2801	Transposase and inactivated derivatives
B37_04485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B37_04486	COG1914	H( )-stimulated, divalent metal cation uptake system
B37_04487	COG2261	transglycosylase associated protein
B37_04488	COG1027	Aspartate ammonia-lyase
B37_04489	COG1819	glycosyl
B37_04490	COG4876	unkown
B37_04491	COG2217	Heavy metal translocating P-type atpase
B37_04493	COG0662	Cupin 2, conserved barrel domain protein
B37_04494	COG3729	General stress protein
B37_04495	COG0628	permease
B37_04496	COG1301	dicarboxylic acid transport
B37_04497	COG1131	(ABC) transporter
B37_04498	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B37_04500	COG1960	acyl-CoA dehydrogenase activity
B37_04503	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B37_04504	COG1181	Belongs to the D-alanine--D-alanine ligase family
B37_04505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B37_04507	COG0513	Belongs to the DEAD box helicase family
B37_04508	COG3402	PFAM membrane-flanked domain
B37_04509	COG3428	Bacterial PH domain
B37_04510	COG0705	Rhomboid family
B37_04511	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B37_04512	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B37_04513	COG0864	Transcriptional regulator
B37_04514	COG2337	Toxic component of a toxin-antitoxin (TA) module
B37_04515	COG1366	Belongs to the anti-sigma-factor antagonist family
B37_04516	COG1366	Belongs to the anti-sigma-factor antagonist family
B37_04517	COG2172	sigma factor antagonist activity
B37_04518	COG2208	phosphoserine phosphatase activity
B37_04520	COG2172	sigma factor antagonist activity
B37_04521	COG1191	sigma factor activity
B37_04522	COG2208	phosphoserine phosphatase activity
B37_04523	COG2183	response to ionizing radiation
B37_04524	COG1309	transcriptional regulator
B37_04525	COG2409	Drug exporters of the RND superfamily
B37_04525	COG1033	growth of symbiont in host cell
B37_04526	COG3091	SprT-like family
B37_04535	COG1476	TRANSCRIPTIONal
B37_04536	COG3239	Fatty acid desaturase
B37_04537	COG1278	Cold shock
B37_04538	COG1063	alcohol dehydrogenase
B37_04540	COG2364	Membrane
B37_04541	COG1846	Transcriptional regulator
B37_04542	COG0456	acetyltransferase
B37_04543	COG2808	Putative FMN-binding domain
B37_04545	COG1733	regulation of RNA biosynthetic process
B37_04546	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B37_04548	COG0583	DNA-binding transcription factor activity
B37_04551	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B37_04552	COG1113	amino acid transport
B37_04555	COG1595	DNA-templated transcription, initiation
B37_04557	COG2755	lipolytic protein G-D-S-L family
B37_04557	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B37_04558	COG2814	Major facilitator Superfamily
B37_04559	COG0745	RESPONSE REGULATOR receiver
B37_04559	COG2972	Histidine kinase
B37_04560	COG3279	Response regulator of the LytR AlgR family
B37_04562	COG3764	Sortase (surface protein transpeptidase)
B37_04563	COG2814	Major facilitator Superfamily
B37_04571	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B37_04572	COG0802	atpase or kinase
B37_04573	COG1214	PFAM Peptidase M22, glycoprotease
B37_04574	COG0456	acetyltransferase
B37_04575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B37_04576	COG0488	(ABC) transporter
B37_04577	COG0315	cyclic pyranopterin monophosphate synthase activity
B37_04578	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B37_04579	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B37_04580	COG0805	protein transport
B37_04582	COG1266	CAAX protease self-immunity
B37_04583	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B37_04584	COG0459	protein refolding
B37_04585	COG4974	Belongs to the 'phage' integrase family
B37_04586	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B37_04608	COG0582	viral genome integration into host DNA
B37_04615	COG1802	Transcriptional regulator
B37_04615	COG4626	Terminase