locus-tag class description B14_00001 ENOG4105CTP PilT protein domain protein B14_00002 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) B14_00003 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) B14_00005 ENOG41066A3 ATP guanido phosphotransferase B14_00006 ENOG4108Z0C Uvrb UvrC protein B14_00023 ENOG4105CRK lysyL-tRNA synthetase B14_00024 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) B14_00026 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase B14_00027 ENOG4105KRF dihydroneopterin aldolase B14_00028 ENOG4105EEI dihydropteroate synthase B14_00029 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 B14_00030 ENOG4105DDQ anthranilate synthase B14_00031 ENOG4105CRQ synthase (Component I) B14_00032 ENOG4105C6T cysteine synthase B14_00033 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase B14_00034 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) B14_00035 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) B14_00036 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) B14_00037 ENOG4108UGV hypoxanthine phosphoribosyltransferase B14_00038 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) B14_00044 ENOG41060GV RNA binding s1 domain protein B14_00047 ENOG4105VYY sporulation protein yabp B14_00048 ENOG41082I2 s4 domain protein B14_00049 ENOG4108IY2 MazG family B14_00051 ENOG4108M14 stage v sporulation protein t B14_00052 ENOG4108JA2 transcriptioN-repair coupling factor B14_00055 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) B14_00056 ENOG4105C5T Phosphoribosyl pyrophosphate synthase B14_00057 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) B14_00058 ENOG4105K4W Could be involved in septation (By similarity) B14_00059 ENOG4105KME endoribonuclease L-psp B14_00060 ENOG4105DFT pur operon repressor B14_00061 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) B14_00063 ENOG4105XEW small acid-soluble spore protein B14_00064 ENOG4105W42 Veg protein B14_00065 ENOG4105XFA sporulation peptidase YabG B14_00066 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) B14_00068 ENOG41069ER domain protein B14_00069 ENOG4105F8V Hydrolase, tatD family B14_00070 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) B14_00071 ENOG4105KRN Transcriptional regulator, abrb family B14_00072 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) B14_00073 ENOG4105VC4 domain protein B14_00074 ENOG41060K3 Methyltransferase B14_00075 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) B14_00076 ENOG4105MA4 psp1 domain protein B14_00077 ENOG4105FA2 dna polymerase iii B14_00078 ENOG4105XVJ Protein of unknown function (DUF327) B14_00079 ENOG4105X0R protein from nitrogen regulatory protein P-II B14_00080 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) B14_00081 ENOG4105CXN decarboxylase B14_00082 ENOG4105CDW Resistance protein B14_00090 ENOG41067KS pro-sigma K processing B14_00092 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) B14_00093 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) B14_00094 ENOG4105C6E dna polymerase iii B14_00095 ENOG4108Z6B deaminase B14_00096 ENOG4105GTG Isochorismatase B14_00097 ENOG4105VRS hydrolase family 18 B14_00099 ENOG4105ZMH deoxynucleoside kinase B14_00102 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR B14_00103 ENOG4107QQ0 gntp family B14_00104 ENOG4105BZW Glycerate kinase B14_00105 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) B14_00106 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) B14_00107 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) B14_00109 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) B14_00116 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B14_00117 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B14_00118 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) B14_00119 ENOG410848D S4 domain protein YaaA B14_00120 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B14_00121 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) B14_00122 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) B14_00125 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) B14_00126 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) B14_00128 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) B14_00130 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) B14_00131 ENOG4107QJE Chromosome Partitioning Protein B14_00132 ENOG4105FA0 parb-like partition protein B14_00133 ENOG4108ZDA Sporulation protein YyaC B14_00135 ENOG4105VDK protein, conserved in bacteria B14_00136 ENOG4105C3G gtp-binding protein B14_00137 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) B14_00138 ENOG4108UUM single-stranded DNA-binding protein B14_00139 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) B14_00141 ENOG4105CHH sulfate transporter B14_00142 ENOG4107YZX Universal stress protein B14_00144 ENOG4108XMW Membrane B14_00145 ENOG4105BZR domain protein B14_00146 ENOG4105K9Q Binds to the 23S rRNA (By similarity) B14_00148 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate B14_00149 ENOG4105FDP GntR family transcriptional regulator B14_00150 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) B14_00151 ENOG4105CE4 GlcNAc 6-P deacetylase B14_00152 ENOG4105DJ2 Major Facilitator Superfamily B14_00156 ENOG4105CDU Replicative dna helicase B14_00158 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis B14_00164 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B14_00165 ENOG4105BZU Histidine kinase B14_00168 ENOG4105Q2H domain protein B14_00169 ENOG4105C0H protease B14_00172 ENOG4105WQG acetyltransferase B14_00175 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) B14_00182 ENOG4105BZU Histidine kinase B14_00183 ENOG4105KCT ABC transporter B14_00184 ENOG4108M15 ABC transporter B14_00189 ENOG4108JU3 Alkyl hydroperoxide reductase B14_00190 ENOG4105D3R alkyl hydroperoxide reductase B14_00191 ENOG4108EKI Dehydrogenase B14_00194 ENOG4105CMG Carbohydrate kinase B14_00196 ENOG4105E2R ROK family B14_00197 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase B14_00198 ENOG4105CMR udp-glucose 4-epimerase B14_00199 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) B14_00201 ENOG4107FKK extracellular solute-binding protein family 1 B14_00203 ENOG4105EG2 ABC transporter, permease B14_00206 ENOG4105DCF alanine dehydrogenase B14_00207 ENOG4105BZG amino acid carrier protein B14_00208 ENOG4105EC8 Methyl-accepting chemotaxis B14_00214 ENOG4105H93 Acyltransferase family B14_00219 ENOG4108V5C ABC transporter B14_00221 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) B14_00223 ENOG410667J hydrolase B14_00224 ENOG4105C5H ABC transporter B14_00225 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) B14_00226 ENOG4105CXY transporter B14_00227 ENOG4107VXM glycerophosphoryl diester phosphodiesterase B14_00228 ENOG4105CPC Aldo Keto reductase B14_00230 ENOG4105C26 Dehydrogenase B14_00231 ENOG4105DH8 myo-inositol catabolism B14_00232 ENOG4105D7K pfkb domain protein B14_00233 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) B14_00234 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) B14_00236 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) B14_00237 ENOG4105F0H myo-inositol catabolism protein B14_00238 ENOG4107TRN Xylose isomerase domain protein TIM barrel B14_00239 ENOG4105D2N Aldolase B14_00244 ENOG4105JKW Valine--pyruvate aminotransferase B14_00246 ENOG4107R8N Glycosyl transferase, family 2 B14_00247 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) B14_00251 ENOG4107RHR regulatoR B14_00252 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) B14_00253 ENOG4105D9N nucleoside B14_00254 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) B14_00260 ENOG4105C1J atp-dependent rna helicase B14_00261 ENOG4106Z5D Glycoside Hydrolase Family 43 B14_00264 ENOG4107QHE Choloylglycine hydrolase B14_00266 ENOG4105C5Y PTS System B14_00267 ENOG4105CS2 ec 3.2.1.21 B14_00269 ENOG4105EWM Histidine kinase B14_00270 ENOG4105C19 ABC transporter B14_00272 ENOG4105EDW glycosyl transferase, family 39 B14_00274 ENOG4107QP3 malate synthase g B14_00277 ENOG4105ETU transcriptional activator (TenA B14_00278 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein B14_00279 ENOG4108JJB ABC transporter B14_00280 ENOG4108W7F transporter, permease B14_00281 ENOG4105CID antiterminator B14_00282 ENOG4105C5Y PTS System B14_00283 ENOG4105CS2 ec 3.2.1.21 B14_00285 ENOG4105CH6 catalase B14_00291 ENOG4105CMR udp-glucose 4-epimerase B14_00292 ENOG4105CKK Glycosyl transferase, family 2 B14_00293 ENOG4105EDW glycosyl transferase, family 39 B14_00298 ENOG4105ETE Transcriptional regulator (LacI family B14_00300 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component B14_00301 ENOG4105DRS transport system, permease B14_00302 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) B14_00304 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B14_00306 ENOG4105JVQ RNA Polymerase B14_00308 ENOG4105CK1 PTS System B14_00309 ENOG4105CS2 ec 3.2.1.21 B14_00311 ENOG4105C5B carbamate kinase B14_00313 ENOG4105DBV ornithine carbamoyltransferase B14_00314 ENOG4105CEU Arginine dihydrolase B14_00316 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) B14_00318 ENOG4105E0M Sulfatase B14_00320 ENOG4105X3H Excalibur domain protein B14_00321 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B14_00322 ENOG4105D2K citrate carrier protein B14_00323 ENOG4107QZ7 Cellulose synthase catalytic subunit B14_00324 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B14_00325 ENOG4107BJW polysaccharide deacetylase B14_00333 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) B14_00334 ENOG4108IMY Transcriptional regulator B14_00335 ENOG4105HDK L-asparaginase B14_00336 ENOG4108IJ0 Aspartate ammonia-lyase B14_00337 ENOG4105DFD Na H antiporter B14_00340 ENOG4108QTI )-transporter B14_00341 ENOG4105C4M (Ubiquinol oxidase) subunit I B14_00342 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B14_00343 ENOG4108JJ9 ABC, transporter B14_00344 ENOG4108JJ8 (ABC) transporter B14_00345 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) B14_00346 ENOG4108J20 pectate lyase B14_00355 ENOG4105CJ1 ABC, transporter B14_00358 ENOG4105CJ1 ABC, transporter B14_00359 ENOG4108TU7 Inherit from COG: (ABC) transporter B14_00360 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B14_00361 ENOG4105G5W regulator Fur family B14_00363 ENOG4105CH6 catalase B14_00368 ENOG41069JR B14_00369 ENOG4105DA5 (ABC) transporter B14_00371 ENOG4105C2C drug resistance transporter, Bcr CflA B14_00374 ENOG4107TDE lipolytic protein G-D-S-L family B14_00375 ENOG4105BZ1 (ABC) transporter B14_00378 ENOG4105CR4 methylisocitrate lyase B14_00379 ENOG4105DXD 2-methylcitrate dehydratase B14_00382 ENOG4108VX5 3-methyladenine DNA glycosylase B14_00384 ENOG4105EMD TRANSCRIPTIONal B14_00385 ENOG4105VZJ PTS System B14_00386 ENOG4105CK1 PTS System B14_00387 ENOG4105VCP PTS System B14_00388 ENOG4105F8D glycoside hydrolase family 4 B14_00390 ENOG4105CM2 brancheD-chain amino acid aminotransferase B14_00391 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B14_00392 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) B14_00393 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein B14_00394 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) B14_00399 ENOG41080V3 Major Facilitator superfamily B14_00400 ENOG4105IIU Aminopeptidase B14_00402 ENOG4105D7K pfkb domain protein B14_00403 ENOG4105EYF MMPL domain protein B14_00404 ENOG4108VB1 regulatoR B14_00405 ENOG4105ENE Histidine kinase B14_00408 ENOG4105X1N Glycosyl transferase family 8 B14_00410 ENOG4105C5I Dehydrogenase B14_00412 ENOG4105DR4 Methyltransferase B14_00413 ENOG4105CK7 Sodium proline symporter B14_00415 ENOG41067MG lrgb family B14_00419 ENOG4105CMU LysR family (Transcriptional regulator B14_00420 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase B14_00421 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) B14_00423 ENOG4105C93 Xylose Isomerase B14_00424 ENOG4105CMG Carbohydrate kinase B14_00427 ENOG4108WS4 fmn reductase B14_00431 ENOG4105CMR udp-glucose 4-epimerase B14_00432 ENOG4105E2S oxidase) subunit II B14_00433 ENOG4105BZ9 Cytochrome C oxidase, subunit I B14_00435 ENOG41060D1 Quinol oxidase B14_00447 ENOG4105DWD nucleoside recognition domain protein B14_00451 ENOG4108DBC nitroreductase B14_00453 ENOG4105DEN Luciferase family B14_00455 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin B14_00458 ENOG4105C5Y PTS System B14_00461 ENOG4105DWF phosphomethylpyrimidine kinase B14_00462 ENOG4108RJ9 Glycosyl transferase, family 2 B14_00463 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) B14_00464 ENOG4105C26 Dehydrogenase B14_00470 ENOG4105CJ1 ABC, transporter B14_00474 ENOG4105CZN Potassium uptake protein B14_00476 ENOG4107JTW chlorite dismutase B14_00477 ENOG4108IJ2 phosphate acetyltransferase B14_00479 ENOG4108FUF Transcriptional regulator, IclR family B14_00484 ENOG4105D2S major facilitator superfamily B14_00486 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) B14_00488 ENOG4108VCI transcription factor, rsfa family B14_00490 ENOG4105DCI Phosphohydrolase B14_00493 ENOG41069HH 4-oxalocrotonate tautomerase B14_00494 ENOG4108Z4T Peptidase M50 B14_00495 ENOG4108XFG YwhD family B14_00496 ENOG4105BZ4 penicillin-binding protein B14_00499 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) B14_00500 ENOG4105CYW agmatinase B14_00501 ENOG410684U Domain of unknown function (DUF1934) B14_00502 ENOG4105C75 arginyL-tRNA synthetase B14_00505 ENOG4105DF6 Fe-S oxidoreductase B14_00507 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B14_00508 ENOG4105C1G acyl-Coa dehydrogenase B14_00509 ENOG4105C1G acyl-Coa dehydrogenase B14_00511 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) B14_00513 ENOG410812K response regulator receiver protein B14_00514 ENOG4105D2N Aldolase B14_00515 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway B14_00516 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B14_00517 ENOG4105CBT Fructose-1,6-bisphosphatase B14_00518 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) B14_00519 ENOG41082DI 50s ribosomal protein l31 B14_00520 ENOG4107104 thymidine kinase B14_00521 ENOG4105C6K Malic enzyme B14_00522 ENOG4107TT2 Auxin Efflux Carrier B14_00524 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase B14_00525 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) B14_00526 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) B14_00529 ENOG4105TRI Hydrolase B14_00532 ENOG4108ZXQ stage ii sporulation protein r B14_00534 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B14_00535 ENOG410815N Probably functions as a manganese efflux pump (By similarity) B14_00536 ENOG4107WAU Protein tyrosine phosphatase B14_00537 ENOG4108YZG isomerase B14_00538 ENOG4108UIC UPF0340 protein B14_00539 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) B14_00540 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) B14_00542 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) B14_00545 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) B14_00546 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) B14_00547 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) B14_00548 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) B14_00549 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) B14_00550 ENOG4106778 Protein of unknown function (DUF1146) B14_00552 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B14_00555 ENOG4108TF4 von Willebrand factor, type A B14_00556 ENOG4108HIZ formate dehydrogenase alpha subunit B14_00557 ENOG4105FCD Major Facilitator B14_00558 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B14_00559 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B14_00562 ENOG4108Z40 Transcriptional regulator B14_00563 ENOG4108RYK Nad-dependent epimerase dehydratase B14_00565 ENOG410874W AraC family transcriptional regulator B14_00569 ENOG4105NIV Esterase B14_00570 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase B14_00571 ENOG4105E4F Isochorismate synthase B14_00572 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase B14_00573 ENOG4105WQI isochorismatase B14_00574 ENOG4105CEY Amp-dependent synthetase and ligase B14_00575 ENOG4105WQT MbtH domain protein B14_00576 ENOG4105C0R drug resistance transporter emrb qaca subfamily B14_00578 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B14_00580 ENOG4107TCE N-acetyltransferase B14_00581 ENOG4105FRN stage II sporulation protein B14_00585 ENOG4105BZU Histidine kinase B14_00586 ENOG4105C37 (CBS) domain B14_00588 ENOG41080XP Cbs domain B14_00589 ENOG4108NA0 Uncharacterized conserved protein (COG2071) B14_00591 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase B14_00592 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase B14_00593 ENOG4105CZM Major Facilitator B14_00594 ENOG4107MII Sugar-specific transcriptional regulator TrmB B14_00595 ENOG4105MT0 Sporulation transcriptional regulator spoiiid B14_00596 ENOG4105DFF Rod shape-determining protein mreb B14_00598 ENOG4105CGA flagellar basal-body rod protein FlgG B14_00599 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) B14_00603 ENOG4105Z8H single-stranded DNA-binding protein B14_00604 ENOG4105DKT Transcriptional regulator B14_00606 ENOG410787A Pts system, glucitol sorbitol-specific B14_00607 ENOG4105DZY Pts system, glucitol sorbitol-specific B14_00608 ENOG4105VI0 Pts system, glucitol sorbitol-specific B14_00609 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase B14_00611 ENOG4105E98 transcriptional regulator DeoR family B14_00612 ENOG410667J hydrolase B14_00614 ENOG4105C0D helicase B14_00615 ENOG4105KBK Zinc finger, swim domain protein B14_00617 ENOG4105HTX biosynthesis protein B14_00618 ENOG4108RB3 Capsular polysaccharide biosynthesis protein B14_00619 ENOG4105FGV Chromate B14_00620 ENOG4105CAH Chromate B14_00622 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) B14_00623 ENOG4107RSM transcriptional regulator B14_00625 ENOG4107FQX Alpha-acetolactate decarboxylase B14_00626 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator B14_00627 ENOG4105CNN ABC, transporter B14_00628 ENOG4105C2J ABC transporter B14_00629 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) B14_00630 ENOG4108RVA ribokinase B14_00631 ENOG4105ETE Transcriptional regulator (LacI family B14_00632 ENOG4105N98 Capsule biosynthesis protein capB B14_00634 ENOG4105PNM synthesis protein B14_00636 ENOG4105K4H Nlp p60 protein B14_00637 ENOG4105J7I hydrolase B14_00638 ENOG4108KGH TRANSCRIPTIONal B14_00639 ENOG4105C54 Major Facilitator superfamily B14_00641 ENOG4105E2A Dehydrogenase B14_00642 ENOG4105CHR reductase B14_00644 ENOG4108M60 Transcriptional regulator B14_00645 ENOG4105D7K pfkb domain protein B14_00646 ENOG4108UHU Aldolase B14_00647 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) B14_00648 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase B14_00650 ENOG4105DG6 mannose-6-phosphate isomerase B14_00652 ENOG4107RZX Teichoic acid biosynthesis protein B14_00654 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase B14_00655 ENOG4107SJB teichoic acid biosynthesis B14_00656 ENOG4107SJB teichoic acid biosynthesis B14_00659 ENOG4105EY8 ABC transporter B14_00660 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B14_00661 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase B14_00662 ENOG4108KGH TRANSCRIPTIONal B14_00664 ENOG4105JFG SpoIID LytB domain protein B14_00665 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B14_00666 ENOG4105D3Q Sugar transferase B14_00667 ENOG4105PSV Polysaccharide Biosynthesis Protein B14_00668 ENOG4107RA4 Glycosyl transferase (Group 1 B14_00669 ENOG4105C6Y Udp-glucose 6-dehydrogenase B14_00670 ENOG4105C1B dTDP-glucose 4-6-dehydratase B14_00671 ENOG4105QZI O-Antigen Polymerase B14_00674 ENOG4107EF8 Glycosyl transferase (Group 1 B14_00675 ENOG4105ESV Glycosyl transferase, family 4 B14_00677 ENOG4108KGH TRANSCRIPTIONal B14_00678 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein B14_00679 ENOG4105BZU Histidine kinase B14_00680 ENOG4105WH1 Two component transcriptional regulator luxr family B14_00684 ENOG4105RU3 B14_00687 ENOG4105E1Q flagellar hook-associated protein B14_00688 ENOG4105DTJ flagellar hook-associated protein B14_00689 ENOG4105MKD B14_00690 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) B14_00691 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) B14_00692 ENOG4105I03 Flagellin B14_00693 ENOG41083S7 flagellar protein FlaG B14_00694 ENOG4107RT6 flagellar hook-associated B14_00695 ENOG4105MQ3 flagellar protein FliS B14_00698 ENOG4105MS2 ribosomal subunit Interface protein B14_00699 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving B14_00700 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) B14_00703 ENOG4105CAK Cell division ATP-binding protein ftsE B14_00704 ENOG4105CRP Part of the ABC transporter FtsEX involved in B14_00706 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) B14_00707 ENOG4105CN1 protease B14_00712 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) B14_00713 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B14_00717 ENOG4108PY7 B14_00718 ENOG41067S9 phage shock protein C, PspC B14_00719 ENOG41086DT Membrane protein of unknown function B14_00720 ENOG41088CQ domain protein B14_00721 ENOG4105C0R drug resistance transporter emrb qaca subfamily B14_00722 ENOG410834F Transcriptional regulator B14_00723 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) B14_00725 ENOG4105HKU nucleoside recognition domain-containing protein B14_00726 ENOG4107XGZ Hydrolase B14_00727 ENOG4108S4C acetyltransferase B14_00728 ENOG4108E16 pectate lyase B14_00730 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) B14_00731 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) B14_00732 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) B14_00733 ENOG4105ECC imidazole-glycerol-phosphate dehydratase B14_00734 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) B14_00735 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase B14_00736 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) B14_00737 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase B14_00740 ENOG4105C3M thioredoxin reductase B14_00741 ENOG4108Z4K mutator MutT protein B14_00742 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) B14_00743 ENOG4105CHW UPF0052 protein B14_00744 ENOG4105CIE May be required for sporulation (By similarity) B14_00745 ENOG4105KRI phosphocarrier protein (HPr B14_00746 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B14_00749 ENOG4108ZHR arsR family transcriptional regulator B14_00750 ENOG4108SQ9 flavin reductase domain protein, FMN-binding B14_00751 ENOG4105C5I Dehydrogenase B14_00752 ENOG4108V2W Carbonate dehydratase B14_00753 ENOG4105CHH sulfate transporter B14_00754 ENOG4107TVP HD domain protein B14_00755 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain B14_00756 ENOG4108URH decarboxylase B14_00757 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B14_00760 ENOG4108HKT sucrose-6-phosphate hydrolase B14_00761 ENOG4105EDQ levansucrase EC 2.4.1.10 B14_00762 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B14_00765 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B14_00767 ENOG4107S2N Type III effector Hrp-dependent B14_00768 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) B14_00770 ENOG4108I5G Major Facilitator superfamily B14_00771 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B14_00774 ENOG4105HTX biosynthesis protein B14_00775 ENOG4108QV3 biosynthesis protein B14_00777 ENOG4108PQP glycosyl transferase group 1 B14_00778 ENOG4105K64 Glycosyl transferase, family 2 B14_00779 ENOG4108KMV Glycosyl transferase (Group 1 B14_00780 ENOG41068W6 Capsular polysaccharide biosynthesis protein B14_00781 ENOG4107QRS glycosyltransferase group 2 family protein B14_00783 ENOG4105K64 Glycosyl transferase, family 2 B14_00785 ENOG4105D3Q Sugar transferase B14_00786 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family B14_00787 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B14_00788 ENOG4108ZPC Polysaccharide pyruvyl transferase B14_00790 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B14_00791 ENOG4105DAA L-lactate B14_00792 ENOG4105JXH GntR family transcriptional regulator B14_00793 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B14_00797 ENOG4105CIG ABC transporter B14_00800 ENOG4105DEN Luciferase family B14_00802 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B14_00803 ENOG4105BZA Phosphoglycerate kinase B14_00804 ENOG4105CP7 Triose-phosphate isomerase B14_00805 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) B14_00806 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) B14_00807 ENOG4108V4B ThiJ pfpI B14_00809 ENOG4108MES Periplasmic binding protein B14_00811 ENOG4105T65 Membrane-associated protein B14_00813 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein B14_00814 ENOG4107HG4 Transcriptional regulator B14_00815 ENOG4108IJ8 ABC transporter B14_00816 ENOG4105E90 ABC transporter B14_00817 ENOG4108HQR Glycine betaine B14_00818 ENOG4105R40 Glycine betaine carnitine choline B14_00823 ENOG4105XZU Preprotein translocase, subunit SecG B14_00825 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) B14_00826 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) B14_00857 ENOG4105CAR Terminase, large subunit B14_00860 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B14_00870 ENOG4108FKH Transglycosylase SLT domain B14_00872 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj B14_00874 ENOG41068G1 B14_00881 ENOG4107EV6 Inherit from COG: YD repeat protein B14_00889 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B14_00895 ENOG4105F0F Oxalate decarboxylase B14_00897 ENOG4106DF4 Sigma-70, region 4 B14_00899 ENOG4105C72 UPF0176 protein B14_00902 ENOG4105D9R oxidoreductase B14_00906 ENOG4106A3M Cytochrome p-450 B14_00907 ENOG410625E B14_00909 ENOG4105F27 Major Facilitator B14_00912 ENOG4105C9F isomerase B14_00913 ENOG4105DET Rhamnulokinase B14_00914 ENOG4105E98 transcriptional regulator DeoR family B14_00915 ENOG4107RKG DJ-1/PfpI family B14_00916 ENOG4105VPX protein, conserved in bacteria B14_00917 ENOG410681U heavy metal transport detoxification protein B14_00918 ENOG4105C59 p-type ATPase B14_00922 ENOG4105DM4 PTS System B14_00923 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) B14_00924 ENOG4105HX0 Transcriptional regulator B14_00926 ENOG4105DSE periplasmic solute binding protein B14_00927 ENOG4105CC5 ABC transporter B14_00928 ENOG4105DIK (ABC) transporter B14_00930 ENOG4105CJQ hydrolase, family 31 B14_00931 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component B14_00932 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component B14_00933 ENOG4108JE9 extracellular solute-binding protein family 1 B14_00934 ENOG4105C59 p-type ATPase B14_00935 ENOG4107ZQN disulfide bond B14_00937 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B14_00939 ENOG4105RHY Pfam:UPF0157 B14_00940 ENOG4105EN6 Membrane B14_00941 ENOG4105EEM helicase B14_00943 ENOG4107EPV Aminotransferase class V B14_00944 ENOG4105EVU fructokinase B14_00947 ENOG4107QZ2 Sulfatase B14_00948 ENOG4107K5X Membrane-bound metal-dependent hydrolase B14_00949 ENOG4105D5Q Arginine ornithine antiporter B14_00950 ENOG4105DQ5 transport system permease protein B14_00951 ENOG4105EHG Permease protein B14_00952 ENOG4105E0A ABC, transporter B14_00953 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B14_00955 ENOG4105D2H Uronic isomerase B14_00956 ENOG4105CT4 transporter B14_00957 ENOG4107KJX Transcriptional regulator B14_00958 ENOG4107QZW Altronate oxidoreductase B14_00959 ENOG4105CTX dehydratase B14_00961 ENOG4105DND Transcriptional regulator B14_00962 ENOG4108RPX mosc domain containing protein B14_00963 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B14_00964 ENOG4105DRR Transcriptional regulator, GntR family B14_00965 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) B14_00966 ENOG4105EHG Permease protein B14_00967 ENOG4105E0A ABC, transporter B14_00968 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B14_00969 ENOG4105C0A alcohol dehydrogenase B14_00970 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) B14_00971 ENOG4105CHR reductase B14_00972 ENOG4108WBT adenosyltransferase B14_00975 ENOG41087YS Phage shock protein A B14_00978 ENOG4105ENE Histidine kinase B14_00979 ENOG4105WH1 Two component transcriptional regulator luxr family B14_00985 ENOG4105C9Q fumarate hydratase class II B14_00986 ENOG41067SE Tetr family transcriptional regulator B14_00988 ENOG4105F3H Histidine kinase B14_00990 ENOG4105C0H protease B14_00991 ENOG4105HUF DNA protection during starvation protein B14_00992 ENOG4105E1F short-chain dehydrogenase reductase B14_00993 ENOG4105DZ1 carboxypeptidase B14_00996 ENOG4108MES Periplasmic binding protein B14_00997 ENOG4105DQ5 transport system permease protein B14_00998 ENOG4108IHU transport system permease protein B14_00999 ENOG4105E0A ABC, transporter B14_01006 ENOG4105CHU acetyl-coa acetyltransferase B14_01007 ENOG4105C1G acyl-Coa dehydrogenase B14_01008 ENOG41080E8 Transcriptional regulator, Spx MgsR family B14_01009 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) B14_01014 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B14_01015 ENOG4108UMI ABC transporter, permease B14_01016 ENOG4105D01 (LipO)protein B14_01018 ENOG4105PGM cation diffusion facilitator family transporter B14_01019 ENOG4105C3K feS assembly ATPase SufC B14_01020 ENOG4105JRK feS assembly protein SufD B14_01021 ENOG4105C9B Cysteine desulfurase B14_01022 ENOG4108UNV SUF system FeS assembly protein, NifU family B14_01023 ENOG4105DIW FeS assembly protein SUFB B14_01028 ENOG4107VFR oxidoreductase B14_01030 ENOG4108K8S endonuclease I B14_01031 ENOG4108I0Q anthranilate phosphoribosyltransferase B14_01032 ENOG4108I0Q anthranilate phosphoribosyltransferase B14_01035 ENOG4105G9B Transcriptional regulator B14_01037 ENOG4105C5R Aminotransferase B14_01039 ENOG4105W1N transcriptional regulator B14_01040 ENOG4105IIP Membrane B14_01041 ENOG4105I3N Conserved Protein B14_01043 ENOG4107R8B 5'-nucleotidase B14_01044 ENOG4105KZD Domain of unknown function (DUF1805) B14_01045 ENOG4108YTE sporulation protein YunB B14_01046 ENOG4105C8J )-transporter B14_01048 ENOG4105FAA peptidase M23 B14_01049 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) B14_01050 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) B14_01051 ENOG4105MMD transcriptional regulator B14_01053 ENOG4105D4U had-superfamily hydrolase, subfamily iia B14_01054 ENOG4108W5N phosphatidylglycerophosphatase a B14_01056 ENOG4105C5I Dehydrogenase B14_01057 ENOG4105D6E homoserine dehydrogenase B14_01058 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) B14_01059 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) B14_01060 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein B14_01061 ENOG41083MR nifu domain-containing protein B14_01064 ENOG4105PY6 Phenolic acid decarboxylase B14_01067 ENOG4108ZMX Domain of unknown function (DU1801) B14_01072 ENOG4108YX9 iron--sulfur cluster insertion protein erpA B14_01073 ENOG4108YM7 Gcn5-related n-acetyltransferase B14_01076 ENOG4105CAY ferredoxin--nadp reductase B14_01077 ENOG4105CEP NADH dehydrogenase B14_01079 ENOG41069ER domain protein B14_01081 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) B14_01086 ENOG4105DCF alanine dehydrogenase B14_01087 ENOG4108K8K Transcriptional regulator B14_01088 ENOG4105BZG amino acid carrier protein B14_01095 ENOG410904N short-chain dehydrogenase reductase B14_01099 ENOG4108Z40 Transcriptional regulator B14_01100 ENOG4105C02 permease B14_01105 ENOG4105DAP Nicotinate phosphoribosyltransferase B14_01106 ENOG4105D58 Diguanylate phosphodiesterase B14_01112 ENOG4105BZU Histidine kinase B14_01114 ENOG4105KA0 thioesterase Superfamily protein B14_01115 ENOG4105KJM monovalent cation h antiporter subunit g B14_01117 ENOG4105SC1 monovalent cation H antiporter subunit E B14_01118 ENOG4108JPZ Monovalent cation H antiporter subunit D B14_01119 ENOG4108ZE9 Monovalent cation H antiporter subunit C B14_01120 ENOG4105HC0 Na H antiporter B14_01121 ENOG4105D65 subunit l B14_01124 ENOG4105DJ4 phosphatidylserine decarboxylase B14_01125 ENOG4107ZTW SNARE associated Golgi B14_01126 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B14_01127 ENOG4108MRH transcriptional regulatory protein B14_01130 ENOG4105KIR Thiol-disulfide oxidoreductase dcc B14_01131 ENOG4105BZ4 penicillin-binding protein B14_01134 ENOG4105Y38 Kinase-associated protein B B14_01136 ENOG4105C87 Aminotransferase class I and II B14_01139 ENOG4108MUZ hydrolase B14_01140 ENOG4108ZB6 transcriptional regulator AsnC family B14_01141 ENOG4105CHM Aminotransferase B14_01143 ENOG4105WG9 Conserved Protein B14_01144 ENOG4107QW4 alcohol dehydrogenase B14_01145 ENOG4107QYV phosphohexose isomerase B14_01146 ENOG4105KNA -acetyltransferase B14_01148 ENOG410900G Protein of unknown function (DUF421) B14_01150 ENOG4107PBV potassium channel B14_01151 ENOG4107PBV potassium channel B14_01154 ENOG4105C37 (CBS) domain B14_01159 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme B14_01160 ENOG4105EA8 2-Nitropropane dioxygenase B14_01162 ENOG4105C8Q Methyl-accepting chemotaxis B14_01163 ENOG4105C8Q Methyl-accepting chemotaxis B14_01164 ENOG4105C8Q Methyl-accepting chemotaxis B14_01165 ENOG4108Z0Z intracellular protease Pfpi family B14_01166 ENOG4105EE0 oxidoreductase B14_01168 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B14_01176 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) B14_01183 ENOG41065RQ ADP-ribosylation crystallin J1 B14_01189 ENOG4105F0F Oxalate decarboxylase B14_01190 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B14_01191 ENOG4105JQZ Methyltransferase B14_01193 ENOG4105TRT Transcriptional regulator B14_01194 ENOG4105C26 Dehydrogenase B14_01195 ENOG4108JB8 alcohol dehydrogenase B14_01196 ENOG4108VNY MOSC domain protein B14_01197 ENOG4106DF1 B14_01199 ENOG4105CZN Potassium uptake protein B14_01201 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) B14_01207 ENOG4105N67 Proton-coupled thiamine transporter YuaJ B14_01208 ENOG4105CMD Transcriptional regulator, GntR family B14_01233 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) B14_01234 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) B14_01236 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) B14_01239 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase B14_01240 ENOG4105E4F Isochorismate synthase B14_01241 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) B14_01242 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) B14_01243 ENOG4108IPT Naphthoate synthase B14_01244 ENOG4105CEY Amp-dependent synthetase and ligase B14_01245 ENOG4105DTQ mandelate racemase muconate lactonizing B14_01251 ENOG4105DSE periplasmic solute binding protein B14_01252 ENOG4105CKI cobalamin synthesis protein B14_01253 ENOG4108V2W Carbonate dehydratase B14_01254 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) B14_01255 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) B14_01258 ENOG4108RMU ferritin dps family protein B14_01262 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component B14_01264 ENOG4105D2X ABC transporter substrate-binding protein B14_01269 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP B14_01270 ENOG4105CAQ asparagine synthetase B14_01271 ENOG4105BZF Glycosyl transferase (Group 1 B14_01272 ENOG4105YVM Phosphoesterase, PA-phosphatase related B14_01273 ENOG4108Z0R Transferase B14_01274 ENOG4105E8V Alpha Beta Hydrolase Fold protein B14_01278 ENOG4105N5T Radical SAM Protein B14_01281 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B14_01282 ENOG4105DVE abc transporter atp-binding protein B14_01284 ENOG4105C19 ABC transporter B14_01285 ENOG4107R34 abc transporter permease protein B14_01286 ENOG4106UBQ B14_01288 ENOG4105D01 (LipO)protein B14_01289 ENOG410605W Major Facilitator B14_01291 ENOG4105C8T Leucyl-tRNA synthetase B14_01292 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase B14_01293 ENOG4107V2S Transcriptional regulator B14_01295 ENOG4105NTD Inherit from COG: Hydrolase B14_01297 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component B14_01299 ENOG41075H3 AraC family transcriptional regulator B14_01301 ENOG4105F5H Glycosyl Hydrolase Family 88 B14_01303 ENOG4105DDC Oxidoreductase domain protein B14_01304 ENOG4105MU9 integral membrane protein B14_01308 ENOG41085GJ domain protein B14_01310 ENOG4105C94 Transporter B14_01311 ENOG4105CBX hi0933 family B14_01314 ENOG4105YW5 deoR family transcriptional regulator B14_01315 ENOG4105C7N Xanthine uracil vitamin C permease B14_01316 ENOG4107QSE Dipeptidase B14_01319 ENOG4105C6T cysteine synthase B14_01320 ENOG4107F58 2'-5' rna ligase B14_01323 ENOG4108IUM Glycogen debranching enzyme B14_01325 ENOG4108V15 phosphotransferase enzyme family B14_01327 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) B14_01328 ENOG4105C8F Beta-lactamase domain protein B14_01329 ENOG4105C6K Malic enzyme B14_01332 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ B14_01335 ENOG4108VDD TRNA binding domain protein B14_01337 ENOG4105DFU Cell wall formation (By similarity) B14_01343 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase B14_01344 ENOG4105ETE Transcriptional regulator (LacI family B14_01345 ENOG4107R0U MotA TolQ exbB proton channel B14_01346 ENOG4105ER2 Ompa motb domain protein B14_01347 ENOG4105DGU Histone deacetylase B14_01348 ENOG4105W87 Cbs domain B14_01349 ENOG4105F1V Acetoin utilization protein B14_01351 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B14_01354 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein B14_01355 ENOG4105KAF membrAne B14_01358 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) B14_01359 ENOG4105BZU Histidine kinase B14_01361 ENOG4105U5Y Transcriptional regulator B14_01366 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) B14_01368 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B14_01371 ENOG4105CW7 secretion protein, HlyD family B14_01373 ENOG4105D07 Signal peptide peptidase, SppA B14_01374 ENOG4105VK3 rdd domain containing protein B14_01376 ENOG4105KBJ sporulation protein ytfj B14_01377 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) B14_01379 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) B14_01380 ENOG4105EPU Molybdenum cofactor synthesis domain protein B14_01381 ENOG4105CDH Citrulline--aspartate ligase B14_01382 ENOG4105CH7 arginosuccinase B14_01385 ENOG4105E8R UPF0173 metal-dependent hydrolase B14_01386 ENOG4105U3E Transcriptional regulator B14_01389 ENOG4105SFS phosphoesterase RecJ domain protein B14_01390 ENOG4106EVM B14_01392 ENOG4105VV2 B14_01393 ENOG4105C0B DNA polymerase III (alpha subunit) B14_01394 ENOG4105C6K Malic enzyme B14_01396 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) B14_01397 ENOG4105CTQ phosphohexokinase B14_01398 ENOG4105CA9 Pyruvate kinase B14_01399 ENOG4105FS0 cytoplasmic membrane protein B14_01400 ENOG4108REF Sporulation integral membrane protein ytvi B14_01401 ENOG4108VMM UPF0756 membrane protein B14_01402 ENOG4105BZN citrate synthase B14_01403 ENOG4108HMX isocitrate dehydrogenase (NADP) B14_01404 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B14_01405 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B14_01406 ENOG4105BZU Histidine kinase B14_01407 ENOG4105C2M dna polymerase I B14_01408 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) B14_01410 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) B14_01411 ENOG4108NR7 pectate lyase B14_01412 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B14_01413 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B14_01415 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) B14_01419 ENOG4108TDW sporulation protein YtxC B14_01420 ENOG4105C22 threonyL-tRNA synthetase B14_01421 ENOG4105U0R haloacid dehalogenase-like hydrolase B14_01423 ENOG4108HRK Histidine kinase B14_01424 ENOG4105DY9 regulatoR B14_01425 ENOG4105DGI Alkaline phosphatase B14_01427 ENOG41067MG lrgb family B14_01428 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) B14_01429 ENOG4105VJV 50s ribosomal protein L35 B14_01430 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) B14_01431 ENOG410696E Membrane B14_01433 ENOG4105CN9 Peptidase m42 family protein B14_01434 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase B14_01435 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) B14_01436 ENOG4105EF1 ribulokinase B14_01437 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase B14_01438 ENOG4108MDK Dehydrogenase B14_01441 ENOG4105DRS transport system, permease B14_01446 ENOG41067MF small acid-soluble spore protein B14_01447 ENOG4108RWN rrna methyltransferase B14_01448 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) B14_01449 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) B14_01452 ENOG4108IUZ ABC transporter B14_01456 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B14_01457 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) B14_01459 ENOG4105DCG PHP domain protein B14_01460 ENOG4105C98 muts2 protein B14_01462 ENOG4105CEY Amp-dependent synthetase and ligase B14_01463 ENOG4107Z3H Transcriptional regulator, TetR family B14_01464 ENOG41060WC Enoyl-CoA hydratase B14_01465 ENOG4105BZJ Electron transfer flavoprotein B14_01466 ENOG4105C10 Electron transfer flavoprotein B14_01467 ENOG4105K63 Thioredoxin B14_01468 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) B14_01469 ENOG4105CFH Aspartokinase B14_01471 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit B14_01473 ENOG4105E33 succinate dehydrogenase B14_01475 ENOG4105EMU Dehydrogenase B14_01476 ENOG4105PFC Transcriptional regulator B14_01477 ENOG41067TZ transcriptional regulator, MarR family B14_01478 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) B14_01479 ENOG4108XJQ germination protein B14_01480 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) B14_01481 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) B14_01482 ENOG4105M59 Phosphodiesterase, mj0936 family B14_01492 ENOG4105DVF Cytosine-specific methyltransferase B14_01497 ENOG4105IG6 Phage terminase, large subunit B14_01498 ENOG4108MDF Phage Portal Protein B14_01501 ENOG4107R37 Glutamate dehydrogenase B14_01503 ENOG4105CM2 brancheD-chain amino acid aminotransferase B14_01504 ENOG4105C7K acetolactate synthase B14_01505 ENOG4108ZP8 Acetolactate synthase small subunit B14_01506 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B14_01507 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) B14_01508 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) B14_01509 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) B14_01510 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) B14_01512 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation B14_01513 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) B14_01514 ENOG4108IUQ atp-dependent protease B14_01515 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) B14_01516 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) B14_01518 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) B14_01520 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) B14_01522 ENOG4105D52 delta-aminolevulinic acid dehydratase B14_01523 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase B14_01524 ENOG41068KH stage VI sporulation protein D B14_01525 ENOG4106AR7 Spore coat protein B14_01527 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) B14_01528 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase B14_01529 ENOG4106A3R peptidase B14_01531 ENOG4108Z03 MAF-like protein B14_01532 ENOG4105W5Q DNA repair protein (RadC B14_01533 ENOG4105DFF Rod shape-determining protein mreb B14_01534 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) B14_01535 ENOG4105YHC Rod shape-determining protein MreD B14_01536 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) B14_01537 ENOG4107QMS site-determining protein B14_01538 ENOG41082BM Transcriptional regulator, arsr family B14_01542 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) B14_01543 ENOG4105X36 (ribosomal) protein B14_01544 ENOG4105K46 50S ribosomal protein l27 B14_01546 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control B14_01547 ENOG41090I5 UPF0735 ACT domain-containing protein B14_01548 ENOG4105CQC Prephenate dehydratase B14_01551 ENOG4108IYU L-aspartate oxidase B14_01552 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase B14_01553 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) B14_01554 ENOG4106678 morphogenetic protein associated with SpoVID B14_01556 ENOG4105CDY transcriptional regulatory protein B14_01559 ENOG4105K7W phage-related replication protein B14_01561 ENOG41069DP small acid-soluble spore protein B14_01565 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) B14_01566 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) B14_01567 ENOG41061AI Protein of unknown function (DUF2905) B14_01568 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) B14_01569 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) B14_01570 ENOG4105VIE preprotein translocase, subunit YajC B14_01571 ENOG4105NAP B14_01572 ENOG4108QG2 Membrane B14_01573 ENOG4105CKP Polysaccharide Biosynthesis Protein B14_01575 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) B14_01576 ENOG41067VP Protein of unknown function (DUF1049) B14_01577 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) B14_01578 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) B14_01579 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B14_01580 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) B14_01581 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B14_01583 ENOG4105CUT histidyl-tRNA synthetase B14_01584 ENOG4105C9M aspartyl-trna synthetase B14_01585 ENOG4105CUZ uba thif-type nad fad binding protein B14_01586 ENOG4105D1H recombination factor protein RarA B14_01588 ENOG4105C3J Cysteine desulfurase B14_01589 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) B14_01591 ENOG4105C7H Helicase, RecD TraA family B14_01593 ENOG41060CR B14_01594 ENOG4105C02 permease B14_01595 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B14_01596 ENOG4105VBH UPF0297 protein B14_01597 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) B14_01598 ENOG4105VPH UPF0473 protein B14_01599 ENOG4105HHA aminodeoxychorismate lyase B14_01600 ENOG4108VQJ O-methyltransferase B14_01601 ENOG4105XYU peptidase (U32 family) B14_01602 ENOG4105CFP Peptidase U32 B14_01604 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) B14_01605 ENOG4107XRG penicillin-binding protein B14_01608 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) B14_01609 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B14_01611 ENOG4105C28 cystathionine B14_01616 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B14_01617 ENOG41082JN Transcriptional regulator B14_01618 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B14_01620 ENOG4105D94 Major Facilitator Superfamily B14_01621 ENOG4107RSM transcriptional regulator B14_01622 ENOG4108V5C ABC transporter B14_01624 ENOG4105EXQ uroporphyrinogen iii synthase hem4 B14_01625 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) B14_01626 ENOG4105KVH Transcriptional regulator B14_01627 ENOG4105F27 Major Facilitator B14_01628 ENOG4105CV8 reductase B14_01629 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B14_01632 ENOG4105WDR B14_01634 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family B14_01635 ENOG4105YHU PTS system B14_01636 ENOG4108IQ3 PTS system B14_01637 ENOG4105ETZ PTS System B14_01638 ENOG4105F3R pts system mannose fructose sorbose family iid B14_01639 ENOG4108HKT sucrose-6-phosphate hydrolase B14_01640 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B14_01642 ENOG410635A Membrane B14_01646 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B14_01647 ENOG4108ZX5 transcriptional regulator B14_01650 ENOG4108JQ7 (ABC) transporter B14_01652 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B14_01653 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B14_01654 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein B14_01655 ENOG4105CAY ferredoxin--nadp reductase B14_01656 ENOG4108S01 response regulator B14_01657 ENOG4108ZGX Histidine kinase B14_01658 ENOG4105ECK Fatty Acid Desaturase B14_01659 ENOG4105KVH Transcriptional regulator B14_01660 ENOG4108VA3 3-hexulose-6-phosphate synthase B14_01661 ENOG41080HJ 6-phospho 3-hexuloisomerase B14_01663 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) B14_01666 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) B14_01667 ENOG4105XTG Pfam:DUF156 B14_01668 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase B14_01669 ENOG4105VFE sira family B14_01670 ENOG4107TPS domain protein B14_01671 ENOG4105VFE sira family B14_01672 ENOG41087NI Sulfite exporter TauE/SafE B14_01673 ENOG4105XXY Thioredoxin B14_01674 ENOG4105BZU Histidine kinase B14_01675 ENOG4105WH1 Two component transcriptional regulator luxr family B14_01685 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B14_01688 ENOG4108ZRV stage ii sporulation protein p B14_01693 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B14_01696 ENOG4108JB9 formate dehydrogenase B14_01697 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) B14_01698 ENOG4105Z7P Acetyltransferase (GNAT) family B14_01701 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase B14_01702 ENOG4105CQW ribosome biogenesis GTPase YqeH B14_01703 ENOG4105E2X shikimate dehydrogenase B14_01704 ENOG410812S Rna-binding protein B14_01705 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) B14_01706 ENOG4108WF2 Metal Dependent Phosphohydrolase B14_01708 ENOG4108D32 Methyltransferase B14_01710 ENOG4105KQC Competence protein B14_01711 ENOG4108UK2 deaminase B14_01712 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 B14_01714 ENOG4105TQK DNA polymerase iii, delta' subunit B14_01717 ENOG4108ZRV stage ii sporulation protein p B14_01719 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) B14_01720 ENOG4105CSA Coproporphyrinogen iii oxidase B14_01721 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) B14_01722 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ B14_01723 ENOG4105CFG Acts as a chaperone (By similarity) B14_01724 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) B14_01725 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) B14_01726 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) B14_01727 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B14_01728 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) B14_01730 ENOG4105VCC 30S ribosomal protein S21 B14_01731 ENOG4105KTH gatB Yqey B14_01732 ENOG4105F7J membrane-bound serine protease B14_01733 ENOG4105DI5 UPF0365 protein B14_01735 ENOG41068P3 sporulation protein YqfC B14_01736 ENOG4105EI1 sporulation protein yqfd B14_01737 ENOG4105C9A Phoh family B14_01738 ENOG4105CTJ Metal Dependent Phosphohydrolase B14_01739 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) B14_01740 ENOG4107YR5 Diacylglycerol kinase B14_01741 ENOG4105KG3 cytidine deaminase B14_01742 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) B14_01744 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) B14_01745 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit B14_01746 ENOG4105C38 Glycyl-tRNA synthetase beta subunit B14_01748 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) B14_01750 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) B14_01751 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B14_01764 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) B14_01765 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) B14_01767 ENOG4105EGD dinuclear metal center protein, YbgI family B14_01768 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) B14_01771 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) B14_01772 ENOG41069ZM Protein of unknown function (DUF2624) B14_01773 ENOG4108JYZ YitT family B14_01774 ENOG4105FDK ABC transporter B14_01775 ENOG4105FAV ABC, transporter B14_01776 ENOG4105N80 Ferric uptake regulator, Fur family B14_01777 ENOG4108U5J '-nucleotidase B14_01778 ENOG41063Y9 B14_01779 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) B14_01782 ENOG4105SXS Protein of unknown function (DUF456) B14_01783 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B14_01785 ENOG4107RF6 penicillin-binding protein B14_01786 ENOG4105CVA phosphate B14_01787 ENOG4105C8U phosphate abc transporter B14_01788 ENOG4105E2Z phosphate ABC transporter (Permease B14_01789 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B14_01790 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B14_01791 ENOG41068DG YceG-like family B14_01795 ENOG4105WDJ 50S ribosomal protein L33 B14_01796 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase B14_01798 ENOG4107ZXI Rhomboid family B14_01801 ENOG4105E0M Sulfatase B14_01808 ENOG4105C5X domain protein B14_01815 ENOG4106855 Competence protein B14_01822 ENOG4105VFR signal peptidase B14_01827 ENOG4105C0D helicase B14_01828 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) B14_01830 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor B14_01831 ENOG4108IJ7 Glycine betaine B14_01832 ENOG4107SQ8 Glycine betaine B14_01834 ENOG4105WZW rhodanese family B14_01835 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) B14_01836 ENOG4105KST dependent repressor B14_01839 ENOG4105CBJ Metal-dependent enzyme B14_01841 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) B14_01842 ENOG4105DC7 peptidase M24 B14_01843 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) B14_01845 ENOG4105CD2 stage iii sporulation protein aa B14_01846 ENOG4105KR5 Stage iii sporulation protein B14_01847 ENOG4108CQH stage III sporulation protein AC B14_01848 ENOG4105KQ4 Stage iii sporulation protein ad B14_01850 ENOG410644B Stage III sporulation protein af B14_01854 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B14_01855 ENOG4108ZSR alkaline shock protein B14_01856 ENOG4105M7K Involved in the transcription termination process (By similarity) B14_01857 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) B14_01858 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B14_01859 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B14_01860 ENOG4105CTB Polyprenyl synthetase B14_01861 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) B14_01862 ENOG4105DX0 Hemolysin A B14_01863 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) B14_01864 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) B14_01865 ENOG4105S1Z Stage IV sporulation protein B B14_01866 ENOG4107QQR Sporulation B14_01868 ENOG4105D7W serine acetyltransferase B14_01871 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B14_01872 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B14_01873 ENOG4106CCJ Protein of unknown function (DUF2627) B14_01874 ENOG4108JUB Transcriptional regulator B14_01876 ENOG4107RDP Dehydrogenase B14_01877 ENOG4105CKM Branched-chain carboxylic acid kinase B14_01880 ENOG4105CPP Dehydrogenase, E1 component B14_01881 ENOG4105C7S Dehydrogenase B14_01882 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) B14_01883 ENOG4108Y6J UPF0403 protein B14_01885 ENOG4108HW3 (ABC) transporter B14_01886 ENOG4105E5Q amino acid AbC transporter B14_01887 ENOG4105CDA abc transporter atp-binding protein B14_01888 ENOG4108QEG Membrane B14_01889 ENOG4108HNZ carboxyl transferase B14_01890 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B14_01891 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) B14_01893 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B14_01894 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) B14_01895 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B14_01896 ENOG4105G6Z alkaline phosphatase B14_01897 ENOG4105VZJ PTS System B14_01898 ENOG4105VCP PTS System B14_01899 ENOG4105CK1 PTS System B14_01900 ENOG4105CS2 ec 3.2.1.21 B14_01901 ENOG4108TZY GntR Family Transcriptional Regulator B14_01905 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase B14_01906 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) B14_01907 ENOG4105WDJ 50S ribosomal protein L33 B14_01909 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B14_01911 ENOG4105II7 pyrroline-5-carboxylate reductase B14_01912 ENOG41069FQ Metallo-beta-lactamase superfamily B14_01913 ENOG4108IXY short-chain dehydrogenase reductase B14_01914 ENOG4105K7W phage-related replication protein B14_01918 ENOG4105DA5 (ABC) transporter B14_01921 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase B14_01922 ENOG4105E5W Transporter B14_01924 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B14_01928 ENOG4107R73 Mate efflux family protein B14_01930 ENOG4108RZA ABC transporter B14_01931 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B14_01932 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B14_01933 ENOG4107RRN ABC transporter substrate-binding protein B14_01935 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold B14_01936 ENOG4105KAC Antibiotic biosynthesis monooxygenase B14_01938 ENOG4105RHY Pfam:UPF0157 B14_01940 ENOG4106HZJ B14_01944 ENOG4105CPC Aldo Keto reductase B14_01946 ENOG4105PF9 Transcriptional regulator B14_01948 ENOG4108YZ4 nudix hydrolase B14_01950 ENOG4107YB6 acetyltransferase, (GNAT) family B14_01953 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease B14_01954 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease B14_01956 ENOG4105CK1 PTS System B14_01957 ENOG4105MZ9 stage II sporulation protein m B14_01958 ENOG4105I3K Ferric uptake regulator, Fur family B14_01960 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B14_01961 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) B14_01962 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) B14_01963 ENOG4105DZ1 carboxypeptidase B14_01964 ENOG41082AN stage II sporulation protein B14_01965 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) B14_01966 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B14_01969 ENOG41090VF Stage v sporulation protein ac B14_01970 ENOG4105CZ3 stage V sporulation protein ad B14_01972 ENOG4105G6R Stage v sporulation protein ae B14_01975 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) B14_01976 ENOG4105K7W phage-related replication protein B14_01977 ENOG4105PTM secreted protein B14_01978 ENOG4107ZE5 PPIases accelerate the folding of proteins B14_01981 ENOG4105MYT Heat shock protein B14_01982 ENOG4105MEW serine threonine protein phosphatase B14_01984 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) B14_01985 ENOG4108R6K riboflavin synthase, subunit alpha B14_01986 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) B14_01987 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) B14_01991 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) B14_01992 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) B14_01994 ENOG4105DZ1 carboxypeptidase B14_01995 ENOG4108JIC nucleoside recognition domain protein B14_01997 ENOG4105FE9 pseudouridine synthase B14_01998 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B14_01999 ENOG4107TWT Cytochrome c biogenesis protein B14_02000 ENOG4105CRE cytochrome C B14_02001 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B14_02002 ENOG4105BZU Histidine kinase B14_02003 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B14_02004 ENOG4105US7 Histidine kinase B14_02011 ENOG4105DR5 peptidase B14_02012 ENOG4108JQ1 Dehydrogenase B14_02013 ENOG4108SAX Membrane B14_02015 ENOG4105T7X B14_02016 ENOG4105C9U ATP-dependent DNA helicase RecQ B14_02017 ENOG4105I7S Abortive infection protein B14_02020 ENOG4107RGJ metallophosphoesterase B14_02023 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase B14_02024 ENOG4105HDK L-asparaginase B14_02027 ENOG4105MSI germination protein ypeb B14_02029 ENOG4105CAT Cytidine monophosphate kinase B14_02030 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) B14_02031 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) B14_02034 ENOG4105S2F B14_02035 ENOG41065D1 B14_02036 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) B14_02037 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase B14_02041 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) B14_02042 ENOG4105K70 DNA-binding protein B14_02043 ENOG4105EUJ GTP cyclohydrolase i B14_02045 ENOG4105XXQ heptaprenyl diphosphate synthase component I B14_02046 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B14_02047 ENOG4105EAH synthase B14_02048 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) B14_02049 ENOG4105BZU Histidine kinase B14_02050 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase B14_02051 ENOG4105D49 3-dehydroquinate synthase B14_02052 ENOG4105KHN chorismate mutase B14_02053 ENOG4105CRQ synthase (Component I) B14_02054 ENOG4108I0Q anthranilate phosphoribosyltransferase B14_02055 ENOG4105DK0 Indole-3-glycerol phosphate synthase B14_02057 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) B14_02058 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) B14_02059 ENOG4105CIH Imidazole acetol-phosphate transaminase B14_02062 ENOG41068YB TPR repeat-containing protein B14_02063 ENOG4108SXZ UPF0302 protein B14_02066 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) B14_02070 ENOG4108JYZ YitT family B14_02071 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase B14_02072 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) B14_02073 ENOG4108Z5K methylglyoxal synthase B14_02074 ENOG4105FJR Lmbe family B14_02075 ENOG4105CPK Glycosyl transferase (Group 1 B14_02076 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate B14_02078 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) B14_02079 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) B14_02080 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) B14_02081 ENOG4105DVT helicase B14_02082 ENOG4105YAC B14_02084 ENOG4105CHM Aminotransferase B14_02087 ENOG4105CSM endonuclease III B14_02089 ENOG4105BZ4 penicillin-binding protein B14_02098 ENOG4108I5C dEAD DEAH box helicase B14_02099 ENOG4107X2U Inherit from COG: Exonuclease-like protein B14_02102 ENOG4108UKS UPF0398 protein B14_02103 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) B14_02104 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) B14_02107 ENOG4105DVT helicase B14_02108 ENOG4105CTD carboxy-peptidase B14_02109 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) B14_02110 ENOG4105C2W permease B14_02111 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B14_02112 ENOG41065KQ synthase B14_02114 ENOG410890F Dynamin family B14_02118 ENOG41081VK Ribonuclease B14_02126 ENOG4108QBV Monogalactosyldiacylglycerol synthase B14_02127 ENOG4105CVG Homoserine O-transsuccinylase B14_02128 ENOG4105CKU formyltetrahydrofolate synthetase B14_02129 ENOG4108V06 Glutathione peroxidase B14_02132 ENOG4105C01 Dihydroxy-acid dehydratase B14_02134 ENOG4107YX5 Pfam:DUF548 B14_02137 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) B14_02139 ENOG4108UT2 hemolysin iii B14_02141 ENOG4105C7B Threonine dehydratase B14_02144 ENOG4108KF3 Electron transport protein SCO1 SenC B14_02145 ENOG41090WU lipolytic protein G-D-S-L family B14_02146 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) B14_02150 ENOG4105BZU Histidine kinase B14_02154 ENOG4105E0X reductase B14_02157 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B14_02160 ENOG4107S4Y M20 DapE family protein YgeY B14_02161 ENOG4108TSC N-acetyltransferase B14_02162 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein B14_02164 ENOG4105VSD UPF0346 protein B14_02168 ENOG410841Q phosphoesterase PA-phosphatase related protein B14_02169 ENOG4106Z5R B14_02172 ENOG4108PJD permease B14_02173 ENOG4105D3A purine nucleoside phosphorylase DeoD-type B14_02174 ENOG4108VXD carboxy-peptidase B14_02178 ENOG4105E1V na solute symporter B14_02180 ENOG4105FBA Phospholipase Carboxylesterase B14_02184 ENOG4107EXU Short-chain dehydrogenase reductase Sdr B14_02186 ENOG4108YQE rare lipoprotein a B14_02189 ENOG4105FR1 rard protein B14_02194 ENOG4105K4H Nlp p60 protein B14_02196 ENOG4105GMT ATPase associated with various cellular activities aaa_5 B14_02197 ENOG4107T89 von Willebrand factor, type A B14_02198 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 B14_02199 ENOG4105C7S Dehydrogenase B14_02200 ENOG4105C09 Bile acid B14_02201 ENOG4105C8J )-transporter B14_02203 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B14_02204 ENOG4105EWU Squalene--hopene cyclase B14_02208 ENOG4105C26 Dehydrogenase B14_02211 ENOG4105SCY DNAK suppressor B14_02212 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) B14_02216 ENOG4105ST3 Transcriptional regulator B14_02217 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B14_02219 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) B14_02223 ENOG4107S9D Alpha beta hydrolase B14_02226 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) B14_02229 ENOG4108NHD germination protein B14_02239 ENOG4108IEG Formate dehydrogenase Alpha subunit B14_02242 ENOG4105UNS Pfam:DUF419 B14_02247 ENOG4105C9U ATP-dependent DNA helicase RecQ B14_02248 ENOG41069ER domain protein B14_02249 ENOG4107RUZ Sss sodium solute transporter superfamily B14_02252 ENOG4108SJC Membrane B14_02253 ENOG4107T8Q Glycosyl transferase (Group 1 B14_02256 ENOG4105C5E polysaccharide biosynthesis protein B14_02258 ENOG4105CUB amino acid B14_02261 ENOG4105KTU Transcriptional regulator, arsr family B14_02263 ENOG4105D29 Helix-turn-helix type 11 domain protein B14_02266 ENOG4108W8B Beta-lactamase domain protein B14_02270 ENOG4105FVX B14_02272 ENOG4105T9C HD domain B14_02274 ENOG4108RZE Tetr family transcriptional regulator B14_02276 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B14_02277 ENOG4108Z7R Chaperone CsaA B14_02278 ENOG4105C8Q Methyl-accepting chemotaxis B14_02281 ENOG4108Q8B Spore germination protein B14_02282 ENOG4108Q8B Spore germination protein B14_02283 ENOG4108NHD germination protein B14_02284 ENOG4108Q8B Spore germination protein B14_02288 ENOG4108J2R molybdopterin oxidoreductase B14_02289 ENOG4105C0R drug resistance transporter emrb qaca subfamily B14_02290 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B14_02293 ENOG4105BZ1 (ABC) transporter B14_02299 ENOG4105C5Q Transcriptional regulator B14_02300 ENOG4105CBC glutamate synthase B14_02301 ENOG4105BZ8 glutamate synthase B14_02305 ENOG4107RCC Major Facilitator Superfamily B14_02306 ENOG4105DIA mandelate racemase muconate lactonizing B14_02308 ENOG41061P3 phosphosulfolactate synthase B14_02309 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) B14_02311 ENOG4105H67 Protein of unknown function (DUF421) B14_02314 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) B14_02315 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) B14_02316 ENOG4105KVH Transcriptional regulator B14_02317 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B14_02318 ENOG4105C1G acyl-Coa dehydrogenase B14_02319 ENOG4105CEY Amp-dependent synthetase and ligase B14_02320 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B14_02321 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit B14_02322 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase B14_02323 ENOG4105E39 Enoyl-CoA hydratase B14_02324 ENOG4107QX3 carboxylase B14_02325 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B14_02331 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family B14_02333 ENOG4105F1A Pyruvate formate-lyase B14_02335 ENOG4105F32 YngK protein B14_02336 ENOG4105CSC Glucose uptake protein B14_02338 ENOG4105CZ9 Domain of unknown function (DU1801) B14_02339 ENOG41082YX Transcriptional regulator, arsr family B14_02340 ENOG4107R5R arsenical pump membrane protein B14_02341 ENOG4108UXE Protein tyrosine phosphatase B14_02342 ENOG4107KJX Transcriptional regulator B14_02343 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit B14_02344 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter B14_02345 ENOG4105CG6 trap dicarboxylate transporter dctm subunit B14_02347 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) B14_02348 ENOG4105DMW Dehydrogenase reductase B14_02349 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B14_02356 ENOG4105DM4 PTS System B14_02357 ENOG4105DG6 mannose-6-phosphate isomerase B14_02358 ENOG4105C1G acyl-Coa dehydrogenase B14_02359 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B14_02360 ENOG4105C26 Dehydrogenase B14_02361 ENOG41060WC Enoyl-CoA hydratase B14_02366 ENOG4105VUF Transcriptional regulator B14_02367 ENOG4105DQ4 alcohol dehydrogenase B14_02369 ENOG4108M26 parallel beta-helix repeat protein B14_02370 ENOG4107UWP Major facilitator superfamily MFS_1 B14_02375 ENOG4108428 Inherit from COG: -acetyltransferase B14_02377 ENOG4107QWR cellulase (EC 3.2.1.4) B14_02378 ENOG4106U2H Protein of unknown function (DUF1360) B14_02379 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) B14_02380 ENOG4105DSQ Nitric oxide reductase B14_02381 ENOG4105IJJ transcriptional regulator, crp fnr family B14_02384 ENOG4107V6Q Cyclic nucleotide-binding domain B14_02391 ENOG4108IUE nitrate reductase beta subunit B14_02392 ENOG4105R3A Nitrate reductase B14_02398 ENOG4105CHR reductase B14_02399 ENOG4107QNK )-transporter B14_02400 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) B14_02403 ENOG4105CMD Transcriptional regulator, GntR family B14_02405 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B14_02406 ENOG4105K4P CoA-binding domain protein B14_02407 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) B14_02408 ENOG4105W8X HesB YadR YfhF-family protein B14_02411 ENOG4105MI2 B14_02416 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B14_02417 ENOG4108I0Z Aconitate hydratase B14_02422 ENOG4107QIV Cytochrome c biogenesis protein B14_02424 ENOG4105VXM UPF0154 protein B14_02426 ENOG4105CV1 Transketolase (EC 2.2.1.1) B14_02427 ENOG4105VPS UPF0291 protein B14_02428 ENOG4108SVB resolvase B14_02430 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B14_02431 ENOG4105WFK nuclease B14_02432 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) B14_02435 ENOG4105CS1 NAD(P)H quinone oxidoreductase B14_02436 ENOG4107XWI flavin reductase domain protein, FMN-binding B14_02437 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase B14_02438 ENOG4108TVJ Nitroreductase B14_02439 ENOG41090MY MarR family Transcriptional regulator B14_02440 ENOG41062JF Transcriptional regulator B14_02445 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B14_02448 ENOG4108MK9 spermidine N(1)-acetyltransferase B14_02468 ENOG4105C5F glutamine synthetase B14_02469 ENOG4105KV4 Transcriptional regulator B14_02470 ENOG4105CXI aluminum resistance protein B14_02471 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B14_02472 ENOG4106F1P AAA ATPase, central domain protein B14_02483 ENOG4105PF9 Transcriptional regulator B14_02490 ENOG4105DRR Transcriptional regulator, GntR family B14_02491 ENOG4105G5W regulator Fur family B14_02492 ENOG4108UNV SUF system FeS assembly protein, NifU family B14_02494 ENOG4105U6W MutT NUDIX family protein B14_02495 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B14_02496 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B14_02497 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) B14_02499 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) B14_02500 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) B14_02504 ENOG4107E54 Small Multidrug Resistance protein B14_02505 ENOG4108X3M OsmC Ohr family protein B14_02507 ENOG4107S9F NmrA family B14_02508 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein B14_02509 ENOG4105M4P Tetr family transcriptional regulator B14_02510 ENOG4105VRS hydrolase family 18 B14_02513 ENOG4107QTZ amino acid B14_02514 ENOG41087PP glycosyltransferase MGT family B14_02515 ENOG4105FQP Beta-lactamase B14_02516 ENOG41080BT SNARE associated Golgi B14_02518 ENOG4105U6C Alpha beta hydrolase fold protein B14_02519 ENOG4105U6C Alpha beta hydrolase fold protein B14_02520 ENOG4108J8C transporter major facilitator family protein B14_02521 ENOG4108J8C transporter major facilitator family protein B14_02522 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) B14_02523 ENOG4105XPP Protein of unknown function (DUF1275) B14_02528 ENOG4107TCE N-acetyltransferase B14_02530 ENOG4105CKI cobalamin synthesis protein B14_02533 ENOG4107EV6 Inherit from COG: YD repeat protein B14_02535 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) B14_02536 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) B14_02539 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B14_02540 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) B14_02541 ENOG4105CPQ Dehydrogenase B14_02542 ENOG4108IGT Dipeptidase B14_02543 ENOG4105MCT stage V sporulation protein S B14_02544 ENOG4105D48 metallophosphoesterase B14_02546 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) B14_02547 ENOG4105CEV competence damage-inducible protein B14_02548 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase B14_02551 ENOG4105XZV Protein of unknown function (DUF3243) B14_02552 ENOG4108RKS Short-chain dehydrogenase reductase Sdr B14_02556 ENOG4105FDP GntR family transcriptional regulator B14_02557 ENOG4105CNU cell division protein FtsK B14_02559 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit B14_02561 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B14_02563 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B14_02564 ENOG4108S0H Dipicolinic acid synthetase, b subunit B14_02565 ENOG4105E35 Dipicolinate synthase subunit A B14_02567 ENOG4105C1V Peptidase, M16 B14_02569 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) B14_02570 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) B14_02571 ENOG4105DTN riboflavin biosynthesis protein ribF B14_02572 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) B14_02573 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) B14_02574 ENOG4105W7A Protein of unknown function (DUF503) B14_02575 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) B14_02576 ENOG4105VHM ribosomal protein B14_02577 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination B14_02578 ENOG4105CHV Transcription elongation factor NusA B14_02579 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) B14_02582 ENOG4105CYP glycoside hydrolase, family B14_02584 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B14_02586 ENOG4105DZP Membrane-associated zinc metalloprotease B14_02588 ENOG4105KNE Phosphatidate cytidylyltransferase B14_02589 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) B14_02590 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) B14_02592 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) B14_02593 ENOG4105CE9 30S ribosomal protein S2 B14_02595 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B14_02596 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) B14_02598 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis B14_02599 ENOG4105CBS Chea signal transduction histidine kinase B14_02600 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) B14_02602 ENOG4105FZW flagellar biosynthesis regulator FlhF B14_02603 ENOG4105D7B Flagellar biosynthesis protein flha B14_02604 ENOG4105D00 flagellar biosynthetic protein flhB B14_02605 ENOG4105D19 Role in flagellar biosynthesis (By similarity) B14_02606 ENOG4105VS8 Flagellar biosynthetic protein fliq B14_02607 ENOG4105CN7 Flagellar biosynthetic protein FliP B14_02609 ENOG4107YTP response regulator receiver protein B14_02610 ENOG4105DD5 Flagellar motor switch protein B14_02611 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B14_02613 ENOG4108JQA flagellar B14_02614 ENOG410822I Flagellar hook capping protein B14_02615 ENOG410696Y Flagellar hook-length control protein B14_02617 ENOG4106YF4 Flagellar biosynthesis chaperone B14_02620 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B14_02621 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) B14_02622 ENOG4105VQ0 flagellar hook-basal body complex protein fliE B14_02623 ENOG4108ZC9 flagellar basal-body rod protein flgc B14_02624 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) B14_02626 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) B14_02627 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) B14_02628 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) B14_02629 ENOG4108HE4 integrase family B14_02630 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) B14_02631 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) B14_02632 ENOG4105C79 DNA protecting protein DprA B14_02633 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha B14_02634 ENOG4105CMV Succinyl-CoA synthetase subunit beta B14_02635 ENOG4105VM1 flagellar B14_02637 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B14_02638 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) B14_02639 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) B14_02640 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) B14_02641 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) B14_02643 ENOG4108BW8 UPF0109 protein B14_02644 ENOG4105K5M 30s ribosomal protein S16 B14_02646 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) B14_02647 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) B14_02648 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) B14_02649 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) B14_02650 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) B14_02651 ENOG4105CHR reductase B14_02652 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase B14_02653 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) B14_02654 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) B14_02655 ENOG4105CB5 ATP-dependent DNA helicase recG B14_02656 ENOG4105EJQ L-serine dehydratase B14_02658 ENOG4105DP4 dak2 domain fusion protein ylov B14_02659 ENOG4108ZAA Alkaline-shock protein B14_02660 ENOG4105VB9 50S ribosomal protein l28 B14_02661 ENOG4105FJ0 thiamine B14_02662 ENOG4105DJV ribulose-phosphate 3-epimerase B14_02663 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) B14_02664 ENOG4105D9P serine threonine protein kinase B14_02665 ENOG4108ZF3 Phosphatase B14_02666 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs B14_02667 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B B14_02668 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) B14_02669 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B14_02670 ENOG4105C25 Primosomal protein n' B14_02671 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase B14_02672 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) B14_02673 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) B14_02674 ENOG4105KC4 UPF0296 protein B14_02675 ENOG4105DSJ YicC domain protein B14_02677 ENOG4105F23 Fibronectin-binding protein B14_02678 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B14_02679 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B14_02680 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B14_02684 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) B14_02687 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) B14_02688 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) B14_02689 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) B14_02690 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain B14_02691 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain B14_02692 ENOG4105CD3 dihydroorotase B14_02693 ENOG4105CXT aspartate transcarbamylase B14_02695 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) B14_02696 ENOG4105C34 Pseudouridine synthase B14_02697 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) B14_02701 ENOG4105DBK s4 domain protein B14_02702 ENOG41067XK integral membrane protein B14_02703 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) B14_02704 ENOG4105DFA alanine racemase domain protein B14_02705 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase B14_02706 ENOG4105WR5 sporulation protein, YlmC YmxH family B14_02707 ENOG4105DHI Methyltransferase B14_02708 ENOG4105DKW ABC transporter B14_02710 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B14_02711 ENOG4105FFI sigma-e processing peptidase spoiiga B14_02714 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) B14_02715 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) B14_02716 ENOG4105K67 small basic protein B14_02718 ENOG4108R2U division initiation protein B14_02719 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) B14_02720 ENOG4105D4A Cell wall formation (By similarity) B14_02721 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B14_02722 ENOG4105CNI cell division protein FtsW B14_02723 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) B14_02724 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) B14_02725 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) B14_02727 ENOG4105CJN penicillin-binding protein B14_02728 ENOG4105CJN penicillin-binding protein B14_02730 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) B14_02731 ENOG4108V6E Cell division protein mraZ B14_02732 ENOG41074B2 UPF0747 protein B14_02736 ENOG41067VY 50S ribosomal protein L32 B14_02737 ENOG4105KNH Nucleic acid-binding protein B14_02738 ENOG4105CDE UPF0348 protein B14_02739 ENOG41063PX domain protein B14_02740 ENOG4105H20 Sporulation integral membrane protein YlbJ B14_02741 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) B14_02742 ENOG4106H78 methyltransferase B14_02748 ENOG4106UY4 Inherit from COG: Scp-like extracellular B14_02749 ENOG41080XQ Signal transduction protein with cbs domains B14_02752 ENOG41064X9 cytochrome C oxidase subunit IV B14_02753 ENOG4105CCU oxidase (Subunit III) B14_02754 ENOG4105BZ9 Cytochrome C oxidase, subunit I B14_02756 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) B14_02758 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) B14_02759 ENOG4105CNI cell division protein FtsW B14_02760 ENOG4105ZPI UPF0358 protein B14_02761 ENOG4105CSV Glutaminase B14_02763 ENOG4108IAB Phoh family B14_02766 ENOG4107SCK Monooxygenase B14_02767 ENOG4108INS Transcriptional regulator B14_02768 ENOG4105QA2 B14_02769 ENOG4105CI3 gtp-binding protein typa B14_02776 ENOG4105ECY inositol monophosphatase B14_02779 ENOG4105WBI UPF0223 protein B14_02780 ENOG4105CXN decarboxylase B14_02784 ENOG4107QN2 dihydrolipoyl dehydrogenase B14_02785 ENOG4105C7S Dehydrogenase B14_02786 ENOG4105CPP Dehydrogenase, E1 component B14_02790 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B14_02792 ENOG4108X4Q Hydrolase B14_02794 ENOG4105CN5 Metallo-Beta-Lactamase B14_02796 ENOG4107ZYR domain protein B14_02797 ENOG4105BZU Histidine kinase B14_02803 ENOG4105C5H ABC transporter B14_02806 ENOG4105C3F Signal peptidase i B14_02807 ENOG4105DM4 PTS System B14_02808 ENOG4105DE4 1-phosphofructokinase B14_02809 ENOG4105E98 transcriptional regulator DeoR family B14_02810 ENOG4107RBB ABC transporter, permease B14_02811 ENOG4105C19 ABC transporter B14_02812 ENOG4107X8C Efflux transporter RND family MFP subunit B14_02814 ENOG4105BZ1 (ABC) transporter B14_02815 ENOG4105BZ1 (ABC) transporter B14_02817 ENOG41067WU Molybdopterin converting factor (Subunit 1) B14_02818 ENOG4108ZAF Molybdopterin B14_02819 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein B14_02820 ENOG4105CVM Molybdenum cofactor synthesis domain protein B14_02821 ENOG4105D06 uba thif-type nad fad binding protein B14_02822 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) B14_02825 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B14_02826 ENOG4105D3R alkyl hydroperoxide reductase B14_02829 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) B14_02830 ENOG4105NQC Flavodoxin B14_02836 ENOG4108XRC Protein of unknown function (DUF458) B14_02838 ENOG4107IN1 Protein of unknown function (DUF1797) B14_02840 ENOG4105EPM Diguanylate phosphodiesterase B14_02841 ENOG4105K6S Short-chain dehydrogenase reductase Sdr B14_02843 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein B14_02845 ENOG4105UIN B14_02846 ENOG4107R88 Chemotaxis protein (CheV) B14_02850 ENOG4105CHM Aminotransferase B14_02851 ENOG4105BZU Histidine kinase B14_02853 ENOG4105K4I Scp-like extracellular B14_02854 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B14_02855 ENOG4105CHR reductase B14_02856 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B14_02858 ENOG4105F6S Spore photoproduct lyase B14_02860 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) B14_02861 ENOG4105KRI phosphocarrier protein (HPr B14_02863 ENOG4105CID antiterminator B14_02867 ENOG4105DC7 peptidase M24 B14_02868 ENOG4105C59 p-type ATPase B14_02871 ENOG4105F0V Cell wall hydrolase B14_02879 ENOG4105VMP Transcriptional regulator B14_02880 ENOG4105NX3 Membrane B14_02885 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) B14_02886 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) B14_02887 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase B14_02888 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) B14_02889 ENOG4108K88 Membrane B14_02891 ENOG4105E14 MotA TolQ exbB proton channel B14_02892 ENOG4105ER2 Ompa motb domain protein B14_02893 ENOG41090MY MarR family Transcriptional regulator B14_02894 ENOG4105BZU Histidine kinase B14_02897 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) B14_02898 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) B14_02900 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate B14_02902 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B14_02904 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) B14_02906 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B14_02907 ENOG4105BZU Histidine kinase B14_02908 ENOG4108TGC Acyltransferase B14_02911 ENOG4107RVG penicillin-binding protein B14_02913 ENOG4105D0M Protease HtpX homolog B14_02915 ENOG410681C small acid-soluble spore protein B14_02917 ENOG4108WZW RNA polymerase sigma B14_02918 ENOG4107TS3 membrane protein, TerC B14_02919 ENOG4107T5V SNARE associated Golgi B14_02920 ENOG4105BZU Histidine kinase B14_02921 ENOG4105FDF Could be involved in DNA repair (By similarity) B14_02922 ENOG4105DQE DNA ligase B14_02926 ENOG4105V75 Transcriptional regulator B14_02928 ENOG4105CJW magnesium transporter B14_02930 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B14_02931 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) B14_02934 ENOG4105CVJ phosphoglycerate mutase B14_02935 ENOG4107Y2X deaminase B14_02937 ENOG4108ZHJ Organic hydroperoxide resistance protein B14_02938 ENOG4105K56 Transcriptional regulator B14_02940 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) B14_02941 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) B14_02942 ENOG4105CIY formyltetrahydrofolate deformylase B14_02943 ENOG41080TC multidrug resistance protein B14_02944 ENOG410839T multidrug resistance protein B14_02949 ENOG4108J20 pectate lyase B14_02951 ENOG4108S4H thioesterase Superfamily protein B14_02952 ENOG4107TUM Amidinotransferase B14_02953 ENOG4108JQ7 (ABC) transporter B14_02954 ENOG4107SN7 NLP P60 protein B14_02955 ENOG4105DTQ mandelate racemase muconate lactonizing B14_02956 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B14_02958 ENOG4105C3U ABC transporter B14_02959 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B14_02960 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B14_02961 ENOG4108ME1 Peptidase M55 D-aminopeptidase B14_02963 ENOG4105C0H protease B14_02966 ENOG4107R7I amino acid B14_02967 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component B14_02969 ENOG4105E0S extracellular solute-binding protein family 1 B14_02970 ENOG4105EKC B14_02972 ENOG4107TDE lipolytic protein G-D-S-L family B14_02973 ENOG4105CPC Aldo Keto reductase B14_02974 ENOG4105CX8 fg-gap repeat protein B14_02975 ENOG4107TDE lipolytic protein G-D-S-L family B14_02977 ENOG4105CX8 fg-gap repeat protein B14_02978 ENOG4105CX8 fg-gap repeat protein B14_02981 ENOG4107TDE lipolytic protein G-D-S-L family B14_02982 ENOG41075H3 AraC family transcriptional regulator B14_02983 ENOG4105F5H Glycosyl Hydrolase Family 88 B14_02984 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component B14_02985 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component B14_02986 ENOG410769Z extracellular solute-binding protein family 1 B14_02987 ENOG4105EQD regulatoR B14_02988 ENOG4105C2F Histidine kinase B14_02990 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) B14_02991 ENOG4107GRR phosphate transport regulator B14_02992 ENOG4105CJ3 phosphate transporter B14_02995 ENOG4108I5G Major Facilitator superfamily B14_02996 ENOG4105CPQ Dehydrogenase B14_02997 ENOG4105DMW Dehydrogenase reductase B14_02998 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) B14_02999 ENOG4105CPQ Dehydrogenase B14_03000 ENOG4107XBN GntR Family Transcriptional Regulator B14_03001 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B14_03004 ENOG41068G1 B14_03005 ENOG41068G1 B14_03007 ENOG410906S phage-like element pbsx protein xkdt B14_03008 ENOG41066EA baseplate J family protein B14_03009 ENOG4105MFU Protein of unknown function (DUF2634) B14_03011 ENOG4105X7F B14_03012 ENOG4108WZM domain protein B14_03013 ENOG4108FKH Transglycosylase SLT domain B14_03014 ENOG4105MTC XkdN-like protein B14_03015 ENOG4105FR7 XkdM protein, phage-like element PBSX B14_03016 ENOG4105PQS phage protein B14_03019 ENOG41060SN B14_03024 ENOG4108MDF Phage Portal Protein B14_03025 ENOG4105IG6 Phage terminase, large subunit B14_03026 ENOG4108TFU terminase (Small subunit) B14_03036 ENOG410635T phage-like element pbsx protein B14_03037 ENOG4105K7W phage-related replication protein B14_03041 ENOG4105J7D transcriptional regulator B14_03042 ENOG4105C0R drug resistance transporter emrb qaca subfamily B14_03043 ENOG41069ER domain protein B14_03045 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase B14_03046 ENOG4108Q5Y Membrane B14_03048 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) B14_03049 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B14_03050 ENOG4105DUM transcriptional regulator, lysR family B14_03052 ENOG4108UW5 maltose o-acetyltransferase B14_03055 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase B14_03056 ENOG4105FQP Beta-lactamase B14_03059 ENOG4105JHY Membrane B14_03060 ENOG4105C28 cystathionine B14_03061 ENOG4105C28 cystathionine B14_03065 ENOG4108ZMI UPF0477 protein B14_03068 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B14_03069 ENOG4105CMR udp-glucose 4-epimerase B14_03070 ENOG4107T5V SNARE associated Golgi B14_03072 ENOG4105ENA helicase B14_03082 ENOG4107A88 B14_03083 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH B14_03084 ENOG4105DWF phosphomethylpyrimidine kinase B14_03085 ENOG4105D06 uba thif-type nad fad binding protein B14_03086 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) B14_03089 ENOG4108VEU Thiamine monophosphate synthase B14_03090 ENOG4105ETU transcriptional activator (TenA B14_03092 ENOG4107S1Q Phosphatase B14_03093 ENOG4105EMS pseudouridine synthase B14_03094 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) B14_03096 ENOG4106EFP UPF0738 protein B14_03097 ENOG4105MIX Adenylate cyclase B14_03098 ENOG4105E4C Lytic transglycosylase catalytic B14_03099 ENOG4108Z18 K06886 hemoglobin B14_03100 ENOG4105T58 Dithiol-disulfide isomerase B14_03102 ENOG4105DPN Oligoendopeptidase f B14_03104 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism B14_03105 ENOG4108V9W transcriptional regulatory protein B14_03109 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis B14_03110 ENOG4108ZCF integral membrane protein B14_03111 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) B14_03113 ENOG4108JQ7 (ABC) transporter B14_03115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B14_03116 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B14_03117 ENOG4108J59 Extracellular solute-binding protein, family 5 B14_03118 ENOG4105C31 Tryptophanyl-tRNA synthetase B14_03123 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B14_03126 ENOG4108JQ7 (ABC) transporter B14_03127 ENOG4105C3U ABC transporter B14_03129 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) B14_03130 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B14_03133 ENOG4107RMD Basic membrane lipoprotein B14_03138 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B14_03139 ENOG4105DBV ornithine carbamoyltransferase B14_03141 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain B14_03142 ENOG4105C8Y Acetylornithine aminotransferase B14_03143 ENOG4105CAS nag kinase B14_03144 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) B14_03145 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase B14_03146 ENOG4105VG1 fes assembly suf system protein B14_03147 ENOG4108MXZ Esterase B14_03148 ENOG4108KP7 hydrolase B14_03149 ENOG41073B9 B14_03150 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) B14_03152 ENOG4107AYK membrAne B14_03153 ENOG4105EPR degv family B14_03156 ENOG4105QNR S1 RNA binding domain protein B14_03157 ENOG4108VPT UPF0234 protein B14_03160 ENOG4105D29 Helix-turn-helix type 11 domain protein B14_03161 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B14_03162 ENOG4105MA6 gCN5-related N-acetyltransferase B14_03167 ENOG4105DY8 decarboxylase B14_03169 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B14_03170 ENOG4108ZUB Lysine exporter protein (Lyse ygga) B14_03175 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) B14_03176 ENOG4105ETE Transcriptional regulator (LacI family B14_03178 ENOG4106HBX Transcriptional Regulator AraC Family B14_03179 ENOG4105UQX Mate efflux family protein B14_03180 ENOG4108YZA Nitrogen regulatory protein pii B14_03182 ENOG4105CAQ asparagine synthetase B14_03187 ENOG4105ERH Fumarylacetoacetate hydrolase B14_03191 ENOG410751J B14_03198 ENOG4105EYH Exonuclease B14_03200 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation B14_03202 ENOG4105E0C molybdate abc transporter B14_03203 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein B14_03205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B14_03206 ENOG4105BZU Histidine kinase B14_03208 ENOG4106K7D Major facilitator family transporter B14_03209 ENOG4105CEY Amp-dependent synthetase and ligase B14_03210 ENOG4105WEF catalase B14_03213 ENOG4108KK1 membrane protein AbrB duplication B14_03215 ENOG4105I1K ABC transporter B14_03216 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component B14_03222 ENOG410780I phosphoprotein phosphatase activity B14_03223 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) B14_03224 ENOG4105C5B carbamate kinase B14_03226 ENOG4107REC cytoplasmic protein B14_03227 ENOG4107R1Q Membrane protein FdrA B14_03228 ENOG4105DG4 malate L-lactate dehydrogenase B14_03229 ENOG4105DG4 malate L-lactate dehydrogenase B14_03230 ENOG4105S0E allantoin catabolism protein B14_03231 ENOG4105CE7 Amidase, hydantoinase carbamoylase family B14_03232 ENOG4105CE7 Amidase, hydantoinase carbamoylase family B14_03233 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) B14_03235 ENOG4105G9B Transcriptional regulator B14_03237 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin B14_03240 ENOG41060YP B14_03241 ENOG4105XVF Competence transcription factor B14_03245 ENOG4106YBV Methyl-accepting chemotaxis B14_03246 ENOG4107TB6 phosphoglycerate mutase B14_03247 ENOG4108U1V ABC transporter, permease B14_03248 ENOG4105DQ5 transport system permease protein B14_03249 ENOG4108HUF Transporter B14_03250 ENOG4108UZ3 Transporter B14_03251 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B14_03252 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 B14_03255 ENOG4108JCI Transcriptional regulator B14_03257 ENOG4105CEY Amp-dependent synthetase and ligase B14_03258 ENOG4105DF9 Lipoate-protein, ligase B14_03259 ENOG4108RQ5 Beta-lactamase domain-containing protein B14_03260 ENOG4106AXD B14_03263 ENOG4105DER m42 family B14_03264 ENOG4105DER m42 family B14_03266 ENOG4105ECB domain protein B14_03268 ENOG4105C1Q protoporphyrinogen oxidase B14_03269 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B14_03270 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) B14_03271 ENOG4105BZ4 penicillin-binding protein B14_03272 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation B14_03278 ENOG4105K59 histidine triad (HIT) protein B14_03279 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) B14_03280 ENOG4105NBU tryptophan transport protein B14_03287 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B14_03289 ENOG4105EQI Metal Dependent Phosphohydrolase B14_03290 ENOG4106D4I domain protein B14_03291 ENOG4107VRP DNA repair exonuclease B14_03292 ENOG4105RHA ABC transporter, permease B14_03293 ENOG4108IUX (ABC) transporter B14_03298 ENOG4105CGU Enoyl-CoA hydratase B14_03300 ENOG4105NCW Trka-c domain protein B14_03301 ENOG4107S91 Sodium hydrogen exchanger B14_03302 ENOG4105D4P Coproporphyrinogen iii oxidase B14_03304 ENOG4105WZB UPF0342 protein B14_03305 ENOG4106MP8 UPF0754 membrane protein B14_03307 ENOG410839P B14_03315 ENOG4105BZ1 (ABC) transporter B14_03316 ENOG4105BZ1 (ABC) transporter B14_03322 ENOG4108N2V aldose 1-epimerase B14_03324 ENOG4105F0I Aminotransferase B14_03325 ENOG4107VMI polysaccharide deacetylase B14_03327 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) B14_03328 ENOG4105D64 Mechanosensitive ion channel B14_03330 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B14_03336 ENOG4105C37 (CBS) domain B14_03339 ENOG4105C37 (CBS) domain B14_03340 ENOG4105U5Y Transcriptional regulator B14_03342 ENOG4105KAF membrAne B14_03344 ENOG4105F6E Acyl-transferase B14_03346 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein B14_03347 ENOG4108AEY RNA polymerase sigma factor B14_03348 ENOG4105J37 B14_03351 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B14_03352 ENOG41086D8 Transcriptional regulator B14_03354 ENOG4105C8J )-transporter B14_03355 ENOG4105CYX Short-chain dehydrogenase reductase Sdr B14_03357 ENOG4105BZN citrate synthase B14_03360 ENOG4105ED1 spovr family B14_03361 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) B14_03362 ENOG4105KPV Transcriptional regulator B14_03366 ENOG4105WH1 Two component transcriptional regulator luxr family B14_03367 ENOG4105BZU Histidine kinase B14_03371 ENOG4105C6V Glycerol-3-phosphate dehydrogenase B14_03372 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) B14_03374 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B14_03375 ENOG4105CB2 alcohol dehydrogenase B14_03376 ENOG4105RK9 auxin efflux carrier B14_03377 ENOG4105TMB Formate nitrite transporter B14_03378 ENOG4105C5H ABC transporter B14_03380 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B14_03381 ENOG4107YBY Hydrolase B14_03382 ENOG41080XP Cbs domain B14_03384 ENOG4108YBP pseudouridine synthase B14_03387 ENOG4105BZU Histidine kinase B14_03393 ENOG4107R6U sodium dicarboxylate symporter B14_03395 ENOG4108UMI ABC transporter, permease B14_03396 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B14_03397 ENOG4105VEQ Cold shock protein B14_03398 ENOG4108TU7 Inherit from COG: (ABC) transporter B14_03399 ENOG4105CJ1 ABC, transporter B14_03401 ENOG4105CS1 NAD(P)H quinone oxidoreductase B14_03402 ENOG4105C0R drug resistance transporter emrb qaca subfamily B14_03403 ENOG4105CW7 secretion protein, HlyD family B14_03404 ENOG4106AKX UPF0229 protein B14_03405 ENOG4105CYN Serine protein kinase B14_03409 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) B14_03411 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) B14_03414 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) B14_03418 ENOG4105DA5 (ABC) transporter B14_03420 ENOG4105VZ8 Transcriptional regulator B14_03421 ENOG4107D63 B14_03422 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) B14_03423 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component B14_03424 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein B14_03425 ENOG4105D7T ABC transporter B14_03426 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) B14_03427 ENOG4105FF2 Type I DHQase B14_03428 ENOG4105C22 threonyL-tRNA synthetase B14_03430 ENOG4107EV6 Inherit from COG: YD repeat protein B14_03456 ENOG4105TUA UPF0295 protein B14_03457 ENOG4105G5W regulator Fur family B14_03458 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B14_03459 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase B14_03460 ENOG4107NBY Membrane B14_03461 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B14_03462 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B14_03463 ENOG4105DEF Extracellular solute-binding protein, family 5 B14_03464 ENOG4108JQ7 (ABC) transporter B14_03465 ENOG4105C3U ABC transporter B14_03466 ENOG4105BZ1 (ABC) transporter B14_03470 ENOG4105CAN Short-chain dehydrogenase reductase Sdr B14_03471 ENOG4106BXE B14_03472 ENOG4105CEN a g-specific adenine glycosylase B14_03473 ENOG41067AE Membrane-bound metal-dependent hydrolase B14_03474 ENOG4105EJV Membrane B14_03476 ENOG4105CKK Glycosyl transferase, family 2 B14_03481 ENOG410691R Modulates RecA activity (By similarity) B14_03482 ENOG4105ECP epimerase B14_03486 ENOG4107Y03 Nitroreductase B14_03487 ENOG4105JAB phenazine biosynthesis protein, phzf family B14_03492 ENOG4105DYS nad(p)h dehydrogenase (quinone) B14_03494 ENOG4106HBX Transcriptional Regulator AraC Family B14_03495 ENOG4105DSG hydrolase family 43 B14_03496 ENOG4105E4I Glycoside hydrolase family 28 B14_03497 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B14_03499 ENOG4105KVH Transcriptional regulator B14_03502 ENOG4105CI1 PTS System B14_03503 ENOG4108Q3X Transcriptional regulator B14_03504 ENOG4105F8D glycoside hydrolase family 4 B14_03505 ENOG4105KK4 UPF0060 membrane protein B14_03506 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family B14_03508 ENOG4107QKR Dehydrogenase B14_03510 ENOG4107RUY (E1 component), alpha subunit B14_03512 ENOG4105GPN Uncharacterized conserved protein (DUF2294) B14_03513 ENOG4108TWJ NADH dehydrogenase subunit 5 B14_03514 ENOG4105EVH UPF0753 protein B14_03518 ENOG41079KZ Major Facilitator Superfamily B14_03525 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B14_03527 ENOG4105D7N magnesium and cobalt transport protein CorA B14_03529 ENOG4105DCT glycerol dehydrogenase B14_03534 ENOG4105UPD Calcium Proton B14_03536 ENOG4108ISG Major Facilitator B14_03538 ENOG4107U9T Pfam:Ribonuclease_BN B14_03540 ENOG4105KJF protein tyrosine phosphatase B14_03541 ENOG4105BZG amino acid carrier protein B14_03543 ENOG4107RKG DJ-1/PfpI family B14_03544 ENOG4105CGH 5'-nucleotidase B14_03545 ENOG4108RCM Nitroreductase B14_03546 ENOG4105KVH Transcriptional regulator B14_03548 ENOG4107QQG Dehydrogenase B14_03551 ENOG4107TVC Glycosyl transferase, family 2 B14_03554 ENOG4108IAJ Nad-dependent epimerase dehydratase B14_03555 ENOG4105D7W serine acetyltransferase B14_03556 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B14_03561 ENOG4107414 GntR family transcriptional regulator B14_03562 ENOG4105CG3 alpha amylase, catalytic region B14_03563 ENOG4105C5Y PTS System B14_03567 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) B14_03570 ENOG4108RPX mosc domain containing protein B14_03571 ENOG410855V Acylphosphatase B14_03572 ENOG41082BM Transcriptional regulator, arsr family B14_03580 ENOG4107QPK )-transporter B14_03583 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein B14_03584 ENOG4105FDU atp-dependent rna helicase B14_03585 ENOG4105C5H ABC transporter B14_03586 ENOG4105DXB Major Facilitator superfamily B14_03587 ENOG4107SWG transcriptional regulator MERR family B14_03589 ENOG4106A3M Cytochrome p-450 B14_03590 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) B14_03591 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) B14_03592 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) B14_03593 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B14_03594 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) B14_03595 ENOG4105CKI cobalamin synthesis protein B14_03597 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase B14_03598 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) B14_03599 ENOG4105C5H ABC transporter B14_03600 ENOG4105C8P )-transporter B14_03601 ENOG4105FKZ Methyl-accepting chemotaxis B14_03602 ENOG4105C26 Dehydrogenase B14_03605 ENOG4105CDY transcriptional regulatory protein B14_03608 ENOG410780I phosphoprotein phosphatase activity B14_03609 ENOG4105CID antiterminator B14_03610 ENOG4105CS2 ec 3.2.1.21 B14_03611 ENOG4105C5Y PTS System B14_03615 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B14_03616 ENOG4105CBD Diacylglycerol kinase B14_03617 ENOG4105DU0 nucleoside hydrolase B14_03618 ENOG4105D9U N-acetyltransferase B14_03621 ENOG4108IG5 Transcriptional regulator B14_03622 ENOG4105D3P Mannan endo-1,4-beta-mannosidase B14_03625 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) B14_03626 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B14_03627 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) B14_03629 ENOG4105CK7 Sodium proline symporter B14_03630 ENOG4105KT7 mgtC SapB transporter B14_03631 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) B14_03632 ENOG4108626 Racemase B14_03633 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) B14_03634 ENOG4106PKC pyridoxal phosphate binding B14_03635 ENOG41080QX K07048 phosphotriesterase-related protein B14_03636 ENOG41080QX K07048 phosphotriesterase-related protein B14_03637 ENOG4106M0N transport system permease protein B14_03638 ENOG4105MUZ Protein of unknown function DUF2620 B14_03640 ENOG4108M21 B14_03642 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) B14_03643 ENOG4105C4R Atp-dependent dna helicase B14_03645 ENOG4105KGF protein, YerC YecD B14_03646 ENOG4108R5T secreted protein B14_03652 ENOG4106A3M Cytochrome p-450 B14_03654 ENOG4105C12 Phosphoribosylglycinamide synthetase B14_03655 ENOG4105DC1 bifunctional purine biosynthesis protein purh B14_03656 ENOG4108V3E phosphoribosylglycinamide formyltransferase B14_03657 ENOG4105CXB phosphoribosylaminoimidazole synthetase B14_03659 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii B14_03661 ENOG4105VR9 phosphoribosylformylglycinamidine synthase B14_03662 ENOG4105C8V SAICAR synthetase B14_03663 ENOG4105C83 adenylosuccinate lyase B14_03664 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit B14_03665 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) B14_03667 ENOG4108U5N UPF0316 protein B14_03670 ENOG4105C7N Xanthine uracil vitamin C permease B14_03671 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) B14_03674 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B14_03678 ENOG4107STQ Multicopper oxidase B14_03679 ENOG4108W3Q Transcriptional regulator B14_03690 ENOG4105GVJ transcriptional regulator B14_03691 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B14_03692 ENOG4107URF beta-phospho-glucomutase B14_03693 ENOG4105CG3 alpha amylase, catalytic region B14_03696 ENOG4105EG2 ABC transporter, permease B14_03697 ENOG4105D56 permease protein B14_03698 ENOG4107FKK extracellular solute-binding protein family 1 B14_03699 ENOG4108IUK alpha amylase, catalytic B14_03700 ENOG4105FKQ transcriptional regulator B14_03701 ENOG4105E5K Alpha-amylase B14_03702 ENOG4108ZJ4 polysaccharide deacetylase B14_03706 ENOG4105CNI cell division protein FtsW B14_03707 ENOG4105CNI cell division protein FtsW B14_03709 ENOG4105N14 lysine exporter protein LysE YggA B14_03710 ENOG4108NGU Transcriptional regulator B14_03713 ENOG4108WV1 Pfam:DUF477 B14_03714 ENOG4105DQX Zinc finger domain B14_03715 ENOG41087YS Phage shock protein A B14_03717 ENOG4105EBR Carboxylesterase B14_03718 ENOG4108VHC Short-chain dehydrogenase reductase Sdr B14_03719 ENOG4105K78 MarR family Transcriptional regulator B14_03721 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B14_03722 ENOG4108X07 Tetr family transcriptional regulator B14_03723 ENOG4108RAV Conserved protein B14_03726 ENOG41073R8 VanW family B14_03732 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) B14_03733 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) B14_03734 ENOG4108TYN CAAX amino terminal protease family protein B14_03736 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B14_03737 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) B14_03738 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) B14_03740 ENOG4105C5H ABC transporter B14_03741 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B14_03742 ENOG410801F ribosomal-protein-alanine acetyltransferase B14_03743 ENOG41072GX Peptidase M22 Glycoprotease B14_03744 ENOG4105K8N protein family UPF0079, ATPase B14_03745 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) B14_03753 ENOG4107QNK )-transporter B14_03754 ENOG4108Z6X (sortase) family B14_03756 ENOG4108NEV two component transcriptional regulator, LytTR family B14_03758 ENOG4105C2C drug resistance transporter, Bcr CflA B14_03759 ENOG4105EXC Acyl-transferase B14_03760 ENOG4108P49 AntiSigma factor B14_03761 ENOG4105JVQ RNA Polymerase B14_03764 ENOG4105C85 amino acid B14_03765 ENOG4107XCH Cyclase family B14_03771 ENOG4105KVH Transcriptional regulator B14_03774 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 B14_03775 ENOG4108U05 Transcriptional regulator B14_03778 ENOG4105CPQ Dehydrogenase B14_03779 ENOG4105VEQ Cold shock protein B14_03780 ENOG4105ECK Fatty Acid Desaturase B14_03781 ENOG4105VZ8 Transcriptional regulator B14_03791 ENOG4105EYF MMPL domain protein B14_03792 ENOG4105ST3 Transcriptional regulator B14_03794 ENOG41064BQ Phosphatase B14_03798 ENOG4107SGM protein serine threonine phosphatase B14_03799 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase B14_03800 ENOG4105FUA antagonist B14_03801 ENOG4107MMM Anti-sigma-factor antagonist B14_03802 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) B14_03804 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B14_03805 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein B14_03807 ENOG4105CKV Membrane B14_03808 ENOG410905X membrane-flanked domain protein B14_03809 ENOG4105C1J atp-dependent rna helicase B14_03811 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) B14_03812 ENOG4105CPF Cell wall formation (By similarity) B14_03813 ENOG4105SZ6 Thioredoxin B14_03816 ENOG4105FDT acyl-CoA dehydrogenase B14_03819 ENOG4105CJ1 ABC, transporter B14_03820 ENOG4105CK2 sodium dicarboxylate symporter B14_03821 ENOG4106F5Q Membrane B14_03822 ENOG4105QVS general stress protein B14_03823 ENOG41082W1 Cupin 2, conserved barrel domain protein B14_03825 ENOG4105EU9 B14_03826 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) B14_03827 ENOG41087PP glycosyltransferase MGT family B14_03828 ENOG4108IJ0 Aspartate ammonia-lyase B14_03829 ENOG4107BMA Transglycosylase associated protein B14_03830 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) B14_03833 ENOG4108M1A Chitin-binding protein B14_03835 ENOG4105C0X amino acid B14_03836 ENOG4105C9U ATP-dependent DNA helicase RecQ B14_03839 ENOG4105VCH membrane B14_03840 ENOG4108RCF TRANSCRIPTIONal B14_03842 ENOG410606W general stress protein B14_03845 ENOG4105CYX Short-chain dehydrogenase reductase Sdr B14_03846 ENOG4105ETD TRANSCRIPTIONal B14_03847 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase B14_03850 ENOG4105XJB lipolytic protein G-D-S-L family B14_03851 ENOG4107258 Transcriptional regulator B14_03853 ENOG4105P4J Allophanate hydrolase, subunit 1 B14_03854 ENOG4105CFM UPF0317 protein B14_03855 ENOG4105C5A transporter B14_03856 ENOG4105E7W lamb ycsf family protein B14_03858 ENOG4108IUS Transketolase B14_03862 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia B14_03864 ENOG4105C8P )-transporter B14_03865 ENOG4105DRR Transcriptional regulator, GntR family B14_03866 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B14_03867 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit B14_03868 ENOG4108IFG nitrite reductase, (NAD(P)H) B14_03869 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) B14_03871 ENOG4108ZYE Transcriptional regulator B14_03872 ENOG4108T5E Copper resistance protein B14_03873 ENOG4105KTB nuclear export factor GLE1 B14_03875 ENOG4108RNG Permease of the drug metabolite transporter B14_03876 ENOG4105C26 Dehydrogenase B14_03877 ENOG4107QTZ amino acid B14_03878 ENOG4108JPW Aminotransferase B14_03880 ENOG4105YVS arsR family transcriptional regulator B14_03881 ENOG41067V3 Antibiotic biosynthesis monooxygenase B14_03882 ENOG4108DBC nitroreductase B14_03884 ENOG4105R8C Transcriptional regulator B14_03887 ENOG4108IPW abc transporter atp-binding protein B14_03888 ENOG4105CM4 permease protein B14_03889 ENOG4105DHS permease protein B14_03890 ENOG4105CFH Aspartokinase B14_03891 ENOG4105C8Q Methyl-accepting chemotaxis B14_03892 ENOG4105BZU Histidine kinase B14_03893 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B14_03894 ENOG4107WD8 ABC transporter, permease B14_03896 ENOG4107TXC Transcriptional regulator B14_03899 ENOG4105E1K spore germination protein B14_03902 ENOG4105DUX Transporter B14_03903 ENOG4107T32 3-phytase (EC 3.1.3.8) B14_03904 ENOG4105C4C beta-galactosidase B14_03905 ENOG410645S MarR family Transcriptional regulator B14_03906 ENOG4105DCM major facilitator superfamily B14_03907 ENOG4108HWW ABC transporter B14_03909 ENOG4105DFW ABC transporter B14_03910 ENOG4105EQD regulatoR B14_03911 ENOG4105C2F Histidine kinase B14_03915 ENOG4107EV6 Inherit from COG: YD repeat protein B14_03923 ENOG41069ZX B14_03924 ENOG41069ZX B14_03925 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) B14_03926 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase B14_03927 ENOG4106P55 Transcriptional regulator B14_03928 ENOG41066UZ arginase EC 3.5.3.1 B14_03929 ENOG4108IQI permease B14_03930 ENOG4105C8Y Acetylornithine aminotransferase B14_03931 ENOG4108JUB Transcriptional regulator B14_03933 ENOG4105DRP amino acid AbC transporter B14_03934 ENOG4105CDA abc transporter atp-binding protein B14_03940 ENOG4105CJ1 ABC, transporter B14_03944 ENOG4108SA1 esterase B14_03945 ENOG4105W8Z 4'-phosphopantetheinyl transferase B14_03947 ENOG4105SX7 Transporter B14_03951 ENOG4105CEY Amp-dependent synthetase and ligase B14_03952 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component B14_03953 ENOG4105F38 ABC transporter, permease B14_03959 ENOG4105C8Q Methyl-accepting chemotaxis B14_03960 ENOG4105C8Q Methyl-accepting chemotaxis B14_03961 ENOG4107WDG serine threonine protein kinase B14_03964 ENOG4105CS2 ec 3.2.1.21 B14_03966 ENOG4105NF4 modulator of drug activity B14_03967 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein B14_03968 ENOG4105E5Q amino acid AbC transporter B14_03972 ENOG4105I82 acetyl xylan esterase B14_03973 ENOG4108PJD permease B14_03975 ENOG4107YHD transcriptional regulator B14_03976 ENOG4105CK7 Sodium proline symporter B14_03977 ENOG4105C26 Dehydrogenase B14_03979 ENOG410756H nucleotidyltransferase B14_03980 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) B14_03987 ENOG4107SWG transcriptional regulator MERR family B14_03989 ENOG4107QIV Cytochrome c biogenesis protein B14_03991 ENOG4108TTB tellurium resistance protein B14_03994 ENOG4107TS3 membrane protein, TerC B14_03995 ENOG4106FN3 tellurium resistance protein B14_03996 ENOG4106FN3 tellurium resistance protein B14_03997 ENOG4108N0M stress protein B14_04001 ENOG4108RZE Tetr family transcriptional regulator B14_04002 ENOG4105CIG ABC transporter B14_04005 ENOG4105Z8B NlpC/P60 family B14_04006 ENOG4105DEN Luciferase family B14_04008 ENOG4105KHC sulfurtransferase B14_04011 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B14_04012 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases B14_04016 ENOG410901P UPF0249 protein B14_04017 ENOG4108X79 transcriptional regulator B14_04018 ENOG4105F8D glycoside hydrolase family 4 B14_04019 ENOG4105CK1 PTS System B14_04020 ENOG4105VCP PTS System B14_04021 ENOG4105VZJ PTS System B14_04022 ENOG4105CQB FAD linked oxidase domain protein B14_04023 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B14_04025 ENOG4107BMA Transglycosylase associated protein B14_04026 ENOG4105DPN Oligoendopeptidase f B14_04028 ENOG4108W0I acetyltransferase B14_04035 ENOG4105MDS 4-oxalocrotonate tautomerase B14_04036 ENOG4108KSA LysR family transcriptional regulator B14_04041 ENOG4105DA5 (ABC) transporter B14_04042 ENOG41060AI SEC-C motif B14_04044 ENOG4106UX7 integral membrane protein B14_04049 ENOG4107TXC Transcriptional regulator B14_04054 ENOG41067TZ transcriptional regulator, MarR family B14_04056 ENOG4106K80 B14_04057 ENOG4108R1P B14_04063 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B14_04064 ENOG4105CTX dehydratase B14_04065 ENOG41073TP transcriptional regulator B14_04066 ENOG4105EQX glucarate dehydratase B14_04067 ENOG4105DJB Major Facilitator Superfamily B14_04068 ENOG4105C26 Dehydrogenase B14_04069 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase B14_04070 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B14_04071 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) B14_04072 ENOG4105DGI Alkaline phosphatase B14_04074 ENOG4105NA0 Transcriptional regulator B14_04076 ENOG4105KNA -acetyltransferase B14_04079 ENOG4105CSV Glutaminase B14_04083 ENOG4108QY0 Membrane B14_04084 ENOG4107TXC Transcriptional regulator B14_04085 ENOG4105CI1 PTS System B14_04087 ENOG4108J5H Homocysteine s-methyltransferase B14_04088 ENOG4108IQI permease B14_04090 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid B14_04093 ENOG4105DFW ABC transporter B14_04094 ENOG4105C8Q Methyl-accepting chemotaxis B14_04095 ENOG4107SCQ Iron-containing alcohol dehydrogenase B14_04099 ENOG4106AXJ AraC family transcriptional regulator B14_04100 ENOG410631K Membrane B14_04105 ENOG4107I77 yiaA/B two helix domain B14_04110 ENOG4105DXI Major Facilitator superfamily B14_04111 ENOG4105C7Z Conserved Protein B14_04119 ENOG4105K4H Nlp p60 protein B14_04121 ENOG4105P1M Domain of unknown function (DUF1874) B14_04130 ENOG4106128 DNA-binding helix-turn-helix protein B14_04131 ENOG4106BHR ftsk SpoIIIE family protein B14_04133 ENOG4108RYM conjugative transposon protein B14_04137 ENOG4108IMY Transcriptional regulator B14_04138 ENOG41068WC Domain of unknown function (DUF955) B14_04141 ENOG4105C7Z Conserved Protein B14_04142 ENOG4105C7Z Conserved Protein B14_04145 ENOG4106DDH Sporulation-specific SASP protein B14_04146 ENOG4105E5W Transporter B14_04152 ENOG41075D4 Aminoglycoside 6-adenylyltransferase B14_04155 ENOG4107ZXU DSBA oxidoreductase B14_04156 ENOG4105BZ1 (ABC) transporter B14_04158 ENOG4108RWP Major Facilitator Superfamily protein B14_04159 ENOG4105WAB arsR family transcriptional regulator B14_04160 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B14_04164 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) B14_04165 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) B14_04166 ENOG4107U5W ybbr family B14_04167 ENOG4105C8B TIGR00159 family B14_04169 ENOG4105EMN RNA polymerase sigma factor B14_04176 ENOG4105EWC Purine nucleoside phosphorylase B14_04177 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate B14_04181 ENOG4105D17 glycoside hydrolase, family 3 domain protein B14_04182 ENOG4105EHZ conserved protein UCP016719 B14_04183 ENOG4105JAB phenazine biosynthesis protein, phzf family B14_04187 ENOG4108A04 Beta-lactamase B14_04194 ENOG4108NMV polysaccharide deacetylase B14_04197 ENOG4105D1F ATP-binding protein B14_04201 ENOG4108UJD 30S ribosomal protein S9 B14_04202 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) B14_04203 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B14_04204 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) B14_04205 ENOG4108JJB ABC transporter B14_04206 ENOG4108JJB ABC transporter B14_04207 ENOG4108ZT0 50S ribosomal protein l17 B14_04208 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B14_04209 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) B14_04210 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits B14_04212 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) B14_04214 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B14_04215 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) B14_04216 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B14_04217 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) B14_04218 ENOG4105VPB 50S ribosomal protein L30 B14_04219 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) B14_04220 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) B14_04221 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) B14_04222 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) B14_04223 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) B14_04224 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits B14_04225 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) B14_04226 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) B14_04227 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal B14_04228 ENOG41082SA 50s ribosomal protein l29 B14_04229 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) B14_04230 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) B14_04231 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) B14_04232 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) B14_04233 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity B14_04234 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) B14_04235 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) B14_04236 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) B14_04237 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) B14_04238 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) B14_04239 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) B14_04240 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) B14_04241 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) B14_04242 ENOG4105XPM ribosomal protein B14_04243 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B14_04244 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B14_04245 ENOG4107Y49 methyltransferase B14_04246 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) B14_04247 ENOG4108VZM 50s ribosomal protein L10 B14_04248 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) B14_04249 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) B14_04250 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) B14_04251 ENOG410683Z Preprotein translocase SecE subunit B14_04252 ENOG4105QIV RNA polymerase B14_04253 ENOG4105M0M Tetracycline resistance protein B14_04254 ENOG4105C2N RNA methyltransferase TrmH family group 3 B14_04255 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) B14_04256 ENOG4105C8N cysteinyl-tRNA synthetase B14_04257 ENOG4105D7W serine acetyltransferase B14_04258 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) B14_04259 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) B14_04260 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) B14_200064 ENOG4105C7H Helicase, RecD TraA family B14_200066 ENOG41069ER domain protein B14_200072 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) B14_200105 ENOG4105C4R Atp-dependent dna helicase B14_200107 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) B14_200118 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B14_200125 ENOG4105I03 Flagellin B14_200146 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) B14_200151 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B14_200153 ENOG4105C0B DNA polymerase III (alpha subunit) B14_200160 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B14_200163 ENOG4108UK2 deaminase B14_200167 ENOG4105U6W MutT NUDIX family protein B14_200168 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B14_200170 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B14_200206 ENOG4105K4H Nlp p60 protein