locus-tag	class	description
B14_00001	COG4956	integral membrane protein (PIN domain superfamily)
B14_00002	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B14_00003	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B14_00004	COG0542	response to heat
B14_00005	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B14_00006	COG3880	PFAM UvrB UvrC protein
B14_00007	COG4463	regulation of RNA biosynthetic process
B14_00023	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B14_00024	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B14_00025	COG1396	sequence-specific DNA binding
B14_00026	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B14_00027	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B14_00028	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B14_00029	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B14_00030	COG0512	Glutamine amidotransferase of anthranilate synthase
B14_00031	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B14_00032	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B14_00033	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B14_00034	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B14_00035	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B14_00036	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B14_00038	COG0037	tRNA processing
B14_00039	COG0515	serine threonine protein kinase
B14_00040	COG2304	oxidoreductase activity
B14_00041	COG2208	phosphoserine phosphatase activity
B14_00044	COG1098	S1 RNA binding domain
B14_00045	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B14_00048	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B14_00049	COG3956	TIGRFAM MazG family protein
B14_00050	COG2244	polysaccharide biosynthetic process
B14_00051	COG2002	toxin-antitoxin pair type II binding
B14_00052	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B14_00054	COG0193	aminoacyl-tRNA hydrolase activity
B14_00055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B14_00056	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B14_00057	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B14_00058	COG2088	sporulation resulting in formation of a cellular spore
B14_00059	COG0251	oxidation-reduction process
B14_00060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B14_00061	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B14_00064	COG4466	Protein conserved in bacteria
B14_00066	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B14_00067	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B14_00068	COG3583	domain protein
B14_00068	COG3584	3D domain protein
B14_00069	COG0084	hydrolase, TatD family'
B14_00070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B14_00070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B14_00071	COG2002	toxin-antitoxin pair type II binding
B14_00072	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B14_00073	COG2827	Endonuclease containing a URI domain
B14_00074	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B14_00075	COG4467	Involved in initiation control of chromosome replication
B14_00076	COG1774	PSP1 C-terminal conserved region
B14_00077	COG0470	DNA polymerase III
B14_00078	COG1728	Protein conserved in bacteria
B14_00079	COG3870	Protein conserved in bacteria
B14_00080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B14_00081	COG1982	Orn Lys Arg decarboxylase major
B14_00082	COG3853	Toxic anion resistance protein (TelA)
B14_00083	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
B14_00092	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B14_00093	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B14_00094	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B14_00095	COG0590	tRNA wobble adenosine to inosine editing
B14_00096	COG1335	isochorismatase
B14_00097	COG3858	chitin binding
B14_00097	COG1388	LysM domain
B14_00098	COG1428	Deoxynucleoside kinase
B14_00099	COG1428	Deoxynucleoside kinase
B14_00102	COG3835	regulator
B14_00103	COG2610	gluconate transmembrane transporter activity
B14_00104	COG1929	Belongs to the glycerate kinase type-1 family
B14_00105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B14_00106	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B14_00107	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B14_00108	COG1686	Belongs to the peptidase S11 family
B14_00109	COG0516	GMP reductase activity
B14_00109	COG0517	IMP dehydrogenase activity
B14_00116	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B14_00117	COG0187	DNA topoisomerase II activity
B14_00118	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B14_00119	COG2501	S4 domain
B14_00120	COG0592	DNA-directed DNA polymerase activity
B14_00121	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B14_00122	COG0594	ribonuclease P activity
B14_00123	COG0706	membrane insertase activity
B14_00124	COG1847	R3H domain protein
B14_00125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B14_00126	COG0445	tRNA wobble uridine modification
B14_00127	COG0357	Ribosomal RNA small subunit methyltransferase G
B14_00128	COG1475	DNA binding
B14_00130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B14_00131	COG1192	Involved in chromosome partitioning
B14_00132	COG1475	DNA binding
B14_00134	COG3949	Membrane
B14_00135	COG4481	Protein conserved in bacteria
B14_00136	COG0012	GTP binding
B14_00137	COG0360	Binds together with S18 to 16S ribosomal RNA
B14_00138	COG0629	single-stranded DNA binding
B14_00139	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B14_00140	COG2271	Major facilitator Superfamily
B14_00141	COG0659	secondary active sulfate transmembrane transporter activity
B14_00142	COG0589	response to stress
B14_00143	COG5577	PFAM Coat F domain
B14_00144	COG4241	membrane
B14_00145	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B14_00146	COG0359	binds to the 23S rRNA
B14_00147	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_00147	COG1263	PTS System
B14_00148	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B14_00150	COG0363	glucosamine-6-phosphate deaminase activity
B14_00151	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B14_00152	COG2807	transmembrane transport
B14_00153	COG3093	addiction module antidote protein HigA
B14_00156	COG0305	Participates in initiation and elongation during chromosome replication
B14_00158	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B14_00159	COG1051	belongs to the nudix hydrolase family
B14_00164	COG0745	RESPONSE REGULATOR receiver
B14_00165	COG5002	protein histidine kinase activity
B14_00166	COG4863	YycH protein
B14_00167	COG4853	Protein conserved in bacteria
B14_00168	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B14_00169	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B14_00172	COG0456	acetyltransferase
B14_00175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B14_00181	COG2197	response regulator
B14_00182	COG4585	Histidine kinase
B14_00183	COG0842	Transport permease protein
B14_00184	COG1131	(ABC) transporter
B14_00189	COG3634	alkyl hydroperoxide reductase activity
B14_00190	COG0450	alkyl hydroperoxide reductase
B14_00191	COG1454	alcohol dehydrogenase
B14_00191	COG1012	belongs to the aldehyde dehydrogenase family
B14_00196	COG1940	carbohydrate kinase activity
B14_00197	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B14_00198	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B14_00200	COG1609	Transcriptional regulator
B14_00201	COG2182	Extracellular solute-binding protein
B14_00202	COG1175	transmembrane transport
B14_00203	COG3833	ABC-type maltose transport systems, permease component
B14_00204	COG1874	Beta-galactosidase
B14_00205	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B14_00206	COG0686	Belongs to the AlaDH PNT family
B14_00207	COG1115	amino acid carrier protein
B14_00208	COG5278	phosphoserine phosphatase activity
B14_00208	COG0840	transmembrane signaling receptor activity
B14_00210	COG0745	RESPONSE REGULATOR receiver
B14_00211	COG2205	protein histidine kinase activity
B14_00212	COG1136	(ABC) transporter
B14_00213	COG0577	efflux transmembrane transporter activity
B14_00214	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
B14_00219	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B14_00223	COG0561	phosphatase activity
B14_00224	COG0488	(ABC) transporter
B14_00225	COG0326	Molecular chaperone. Has ATPase activity
B14_00226	COG2271	Major facilitator Superfamily
B14_00227	COG0584	glycerophosphoryl diester phosphodiesterase
B14_00228	COG0667	Aldo Keto reductase
B14_00229	COG1349	DNA-binding transcription factor activity
B14_00230	COG1012	belongs to the aldehyde dehydrogenase family
B14_00231	COG3718	enzyme involved in inositol metabolism
B14_00232	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B14_00233	COG3962	Belongs to the TPP enzyme family
B14_00234	COG1082	Xylose isomerase domain protein TIM barrel
B14_00235	COG2814	Major facilitator Superfamily
B14_00236	COG0673	inositol 2-dehydrogenase activity
B14_00237	COG1082	Xylose isomerase domain protein TIM barrel
B14_00238	COG1082	Xylose isomerase domain protein TIM barrel
B14_00239	COG0191	fructose-bisphosphate aldolase activity
B14_00241	COG1181	Belongs to the D-alanine--D-alanine ligase family
B14_00244	COG3977	Valine--pyruvate aminotransferase
B14_00246	COG1215	transferase activity, transferring glycosyl groups
B14_00247	COG5298	Protein conserved in bacteria
B14_00248	COG3706	GGDEF domain
B14_00249	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B14_00251	COG2390	Transcriptional regulator
B14_00252	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B14_00253	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B14_00254	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B14_00260	COG0513	Belongs to the DEAD box helicase family
B14_00261	COG3507	Belongs to the glycosyl hydrolase 43 family
B14_00264	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B14_00266	COG2190	(PTS) system
B14_00266	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_00266	COG1263	PTS System
B14_00267	COG2723	6-phospho-beta-galactosidase activity
B14_00268	COG0745	RESPONSE REGULATOR receiver
B14_00269	COG2205	protein histidine kinase activity
B14_00270	COG1136	(ABC) transporter
B14_00271	COG0577	efflux transmembrane transporter activity
B14_00272	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B14_00274	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B14_00275	COG2224	Isocitrate lyase
B14_00277	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B14_00278	COG4721	ABC-type cobalt transport system, permease component
B14_00279	COG1122	ATPase activity
B14_00280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B14_00281	COG3711	transcriptional antiterminator
B14_00282	COG1263	PTS System
B14_00282	COG2190	(PTS) system
B14_00282	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_00283	COG2723	6-phospho-beta-galactosidase activity
B14_00285	COG0693	protein deglycase activity
B14_00285	COG0753	catalase activity
B14_00286	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B14_00291	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B14_00292	COG0463	Glycosyl transferase, family 2
B14_00293	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B14_00294	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B14_00298	COG1609	Transcriptional regulator
B14_00300	COG1175	transmembrane transport
B14_00301	COG0395	ABC-type sugar transport system, permease component
B14_00302	COG2223	nitrite transmembrane transporter activity
B14_00303	COG1621	beta-fructofuranosidase activity
B14_00304	COG2195	Cleaves the N-terminal amino acid of tripeptides
B14_00306	COG1595	DNA-templated transcription, initiation
B14_00308	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B14_00309	COG2723	6-phospho-beta-galactosidase activity
B14_00311	COG0549	Belongs to the carbamate kinase family
B14_00313	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B14_00314	COG2235	arginine
B14_00316	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B14_00318	COG1368	sulfuric ester hydrolase activity
B14_00321	COG0584	glycerophosphoryl diester phosphodiesterase
B14_00322	COG3493	citrate carrier protein
B14_00323	COG1215	transferase activity, transferring glycosyl groups
B14_00324	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B14_00325	COG0726	polysaccharide deacetylase
B14_00328	COG5294	Protein conserved in bacteria
B14_00329	COG0577	efflux transmembrane transporter activity
B14_00330	COG1136	(ABC) transporter
B14_00331	COG2205	protein histidine kinase activity
B14_00332	COG0745	RESPONSE REGULATOR receiver
B14_00333	COG2706	6-phosphogluconolactonase activity
B14_00334	COG1396	sequence-specific DNA binding
B14_00335	COG0252	asparaginase activity
B14_00336	COG1027	Aspartate ammonia-lyase
B14_00337	COG1757	Na H antiporter
B14_00338	COG0281	malic enzyme
B14_00340	COG2116	formate transmembrane transporter activity
B14_00341	COG1271	oxidase subunit
B14_00342	COG1294	oxidase, subunit
B14_00343	COG4988	ABC transporter
B14_00344	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B14_00345	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B14_00346	COG3866	Pectate lyase
B14_00355	COG1131	(ABC) transporter
B14_00358	COG1131	(ABC) transporter
B14_00359	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B14_00361	COG0735	belongs to the Fur family
B14_00362	COG0753	catalase activity
B14_00363	COG0753	catalase activity
B14_00364	COG2814	Major facilitator Superfamily
B14_00365	COG1595	DNA-templated transcription, initiation
B14_00369	COG1131	(ABC) transporter
B14_00370	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B14_00371	COG2814	Major facilitator Superfamily
B14_00374	COG2755	lipolytic protein G-D-S-L family
B14_00375	COG1132	(ABC) transporter
B14_00378	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B14_00379	COG2079	MmgE PrpD family protein
B14_00380	COG0372	Belongs to the citrate synthase family
B14_00382	COG2094	Belongs to the DNA glycosylase MPG family
B14_00384	COG3711	transcriptional antiterminator
B14_00384	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B14_00385	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B14_00386	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B14_00387	COG1447	Phosphotransferase system cellobiose-specific component IIA
B14_00388	COG1486	melibiose metabolic process
B14_00389	COG2814	Major facilitator Superfamily
B14_00390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B14_00391	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B14_00392	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B14_00393	COG1696	Membrane protein involved in D-alanine export
B14_00394	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B14_00397	COG2357	RelA SpoT domain protein
B14_00399	COG0477	Major facilitator Superfamily
B14_00400	COG2234	aminopeptidase activity
B14_00402	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B14_00403	COG2409	Drug exporters of the RND superfamily
B14_00404	COG2197	response regulator
B14_00405	COG4585	Histidine kinase
B14_00408	COG1442	glycosyl transferase family 8
B14_00410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B14_00411	COG0346	lactoylglutathione lyase activity
B14_00412	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B14_00413	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B14_00415	COG1346	cytolysis
B14_00416	COG1380	Effector of murein hydrolase LrgA
B14_00419	COG0583	DNA-binding transcription factor activity
B14_00420	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B14_00421	COG0352	thiamine-phosphate diphosphorylase activity
B14_00423	COG2115	Belongs to the xylose isomerase family
B14_00424	COG1070	Carbohydrate kinase
B14_00425	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B14_00426	COG3162	membrane
B14_00427	COG0655	NAD(P)H dehydrogenase (quinone) activity
B14_00431	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B14_00432	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B14_00433	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B14_00435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B14_00443	COG0456	acetyltransferase
B14_00448	COG0772	Belongs to the SEDS family
B14_00449	COG0772	Belongs to the SEDS family
B14_00450	COG1473	amidohydrolase
B14_00451	COG0778	Nitroreductase
B14_00453	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B14_00455	COG1404	Belongs to the peptidase S8 family
B14_00457	COG3711	transcriptional antiterminator
B14_00458	COG1263	PTS System
B14_00458	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_00459	COG1621	beta-fructofuranosidase activity
B14_00461	COG0351	phosphomethylpyrimidine kinase
B14_00462	COG1216	Glycosyl transferase, family 2
B14_00463	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B14_00464	COG1012	belongs to the aldehyde dehydrogenase family
B14_00466	COG2233	PERMEase
B14_00467	COG2363	Small membrane protein
B14_00470	COG1131	(ABC) transporter
B14_00474	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B14_00477	COG0280	phosphate acetyltransferase
B14_00479	COG1414	Transcriptional regulator
B14_00484	COG2814	Major facilitator Superfamily
B14_00489	COG4844	belongs to the
B14_00490	COG1078	dGTPase activity
B14_00491	COG3465	dGTPase activity
B14_00493	COG1942	4-Oxalocrotonate Tautomerase
B14_00494	COG1994	Peptidase M50
B14_00496	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B14_00499	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B14_00500	COG0010	Belongs to the arginase family
B14_00501	COG4506	Protein conserved in bacteria
B14_00502	COG0018	arginyl-trna synthetase
B14_00504	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B14_00505	COG2181	nitrate reductase activity
B14_00505	COG0247	lactate metabolic process
B14_00506	COG0183	Belongs to the thiolase family
B14_00507	COG1250	3-hydroxyacyl-CoA dehydrogenase
B14_00508	COG1960	acyl-CoA dehydrogenase activity
B14_00509	COG1960	acyl-CoA dehydrogenase activity
B14_00510	COG3343	RNA polymerase activity
B14_00511	COG0504	CTP synthase activity
B14_00512	COG4821	SIS domain
B14_00513	COG2204	response regulator
B14_00514	COG0191	fructose-bisphosphate aldolase activity
B14_00515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B14_00516	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B14_00517	COG1494	fructose-1,6-bisphosphatase
B14_00518	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B14_00519	COG0254	rRNA binding
B14_00520	COG1435	thymidine kinase activity
B14_00521	COG0281	malic enzyme
B14_00522	COG0679	Auxin Efflux Carrier
B14_00523	COG0789	Transcriptional regulator
B14_00524	COG0346	lactoylglutathione lyase activity
B14_00525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B14_00526	COG2890	protein-(glutamine-N5) methyltransferase activity
B14_00527	COG1609	Transcriptional regulator
B14_00528	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B14_00529	COG0561	phosphatase activity
B14_00530	COG0673	inositol 2-dehydrogenase activity
B14_00531	COG0738	Major facilitator superfamily
B14_00533	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B14_00534	COG0009	L-threonylcarbamoyladenylate synthase
B14_00535	COG1971	Probably functions as a manganese efflux pump
B14_00536	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B14_00537	COG0698	ribose 5-phosphate isomerase
B14_00538	COG4475	Protein of unknown function (DUF436)
B14_00539	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B14_00540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B14_00543	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B14_00544	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B14_00545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B14_00546	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B14_00547	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B14_00548	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B14_00549	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B14_00550	COG4836	Membrane
B14_00552	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B14_00553	COG2385	sporulation resulting in formation of a cellular spore
B14_00554	COG2304	oxidoreductase activity
B14_00555	COG2304	oxidoreductase activity
B14_00556	COG3383	formate dehydrogenase (NAD+) activity
B14_00558	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B14_00559	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B14_00560	COG1994	Peptidase M50
B14_00562	COG1959	2 iron, 2 sulfur cluster binding
B14_00563	COG2910	NAD(P)H-binding
B14_00565	COG2207	Transcriptional regulator
B14_00565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B14_00566	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B14_00567	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B14_00568	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B14_00569	COG2819	hydrolase of the alpha beta superfamily
B14_00570	COG1028	Short-chain dehydrogenase reductase Sdr
B14_00571	COG1169	isochorismate synthase
B14_00572	COG1021	2,3-dihydroxybenzoate-AMP ligase
B14_00573	COG1535	isochorismatase
B14_00573	COG3433	isochorismatase activity
B14_00574	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B14_00575	COG3251	PFAM MbtH domain protein
B14_00576	COG0477	Major facilitator Superfamily
B14_00578	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B14_00580	COG1247	-acetyltransferase
B14_00581	COG0739	heme binding
B14_00583	COG0740	serine-type endopeptidase activity
B14_00584	COG0347	Belongs to the P(II) protein family
B14_00585	COG0004	ammonium transporteR
B14_00586	COG1253	flavin adenine dinucleotide binding
B14_00587	COG0598	Magnesium transport protein CorA
B14_00588	COG0517	IMP dehydrogenase activity
B14_00589	COG3361	conserved protein (COG2071)
B14_00590	COG3546	catalase activity
B14_00591	COG1227	inorganic diphosphatase activity
B14_00592	COG0671	phosphoesterase, PA-phosphatase related
B14_00593	COG2814	Major facilitator Superfamily
B14_00594	COG1846	Transcriptional regulator
B14_00595	COG1609	Transcriptional regulator
B14_00596	COG1077	Cell shape determining protein MreB Mrl
B14_00597	COG4786	Flagellar basal body rod
B14_00598	COG4786	Flagellar basal body rod
B14_00599	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B14_00600	COG1970	mechanosensitive ion channel activity
B14_00603	COG0629	single-stranded DNA binding
B14_00607	COG3732	PTS system glucitol sorbitol-specific
B14_00609	COG1028	Short-chain dehydrogenase reductase Sdr
B14_00611	COG1349	DNA-binding transcription factor activity
B14_00612	COG0561	phosphatase activity
B14_00614	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B14_00615	COG4715	Zinc finger, swim domain protein
B14_00617	COG3944	biosynthesis protein
B14_00618	COG4464	protein tyrosine phosphatase activity
B14_00619	COG2059	Chromate
B14_00620	COG2059	Chromate
B14_00621	COG1522	sequence-specific DNA binding
B14_00622	COG0405	Gamma-glutamyltransferase
B14_00623	COG0583	DNA-binding transcription factor activity
B14_00624	COG0028	Belongs to the TPP enzyme family
B14_00625	COG3527	Alpha-acetolactate decarboxylase
B14_00626	COG1879	ABC-type sugar transport system periplasmic component
B14_00627	COG1172	Belongs to the binding-protein-dependent transport system permease family
B14_00628	COG1129	ABC transporter
B14_00629	COG1869	D-ribose catabolic process
B14_00630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B14_00631	COG1609	Transcriptional regulator
B14_00632	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B14_00634	COG2843	Capsule synthesis protein
B14_00636	COG0791	NLP P60 protein
B14_00637	COG0561	phosphatase activity
B14_00638	COG1316	TRANSCRIPTIONal
B14_00639	COG2814	Major facilitator Superfamily
B14_00641	COG1063	alcohol dehydrogenase
B14_00642	COG1028	Short-chain dehydrogenase reductase Sdr
B14_00643	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B14_00644	COG1609	Transcriptional regulator
B14_00645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B14_00646	COG0800	Aldolase
B14_00650	COG1482	cell wall glycoprotein biosynthetic process
B14_00651	COG4193	domain, Protein
B14_00652	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B14_00653	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B14_00654	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B14_00655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B14_00656	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B14_00656	COG0463	Glycosyl transferase, family 2
B14_00658	COG1682	transport, permease protein
B14_00659	COG1134	teichoic acid transport
B14_00660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B14_00661	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B14_00662	COG1316	TRANSCRIPTIONal
B14_00664	COG2247	cell wall binding repeat
B14_00664	COG2385	sporulation resulting in formation of a cellular spore
B14_00665	COG0860	N-Acetylmuramoyl-L-alanine amidase
B14_00665	COG2247	cell wall binding repeat
B14_00667	COG2244	polysaccharide biosynthetic process
B14_00668	COG0438	transferase activity, transferring glycosyl groups
B14_00668	COG0297	glycogen (starch) synthase activity
B14_00669	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B14_00670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B14_00671	COG3307	-O-antigen
B14_00672	COG3206	protein involved in exopolysaccharide biosynthesis
B14_00673	COG1215	transferase activity, transferring glycosyl groups
B14_00674	COG0438	transferase activity, transferring glycosyl groups
B14_00675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B14_00677	COG1316	TRANSCRIPTIONal
B14_00678	COG1739	Uncharacterized protein family UPF0029
B14_00679	COG4585	Histidine kinase
B14_00680	COG2197	response regulator
B14_00681	COG1307	EDD domain protein, DegV family
B14_00682	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B14_00685	COG2747	anti-sigma28 factor FlgM
B14_00686	COG3418	PFAM FlgN family protein
B14_00687	COG1256	bacterial-type flagellum assembly
B14_00687	COG4786	Flagellar basal body rod
B14_00688	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B14_00690	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B14_00691	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B14_00692	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B14_00693	COG1334	flagellar protein FlaG
B14_00694	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B14_00695	COG1516	flagellar protein fliS
B14_00698	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B14_00699	COG0653	protein targeting
B14_00700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B14_00701	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B14_00702	COG2010	Cytochrome c
B14_00703	COG2884	Cell division ATP-binding protein ftsE
B14_00704	COG2177	Part of the ABC transporter FtsEX involved in
B14_00705	COG0791	NLP P60 protein
B14_00705	COG3883	PFAM NLP P60 protein
B14_00706	COG0473	3-isopropylmalate dehydrogenase activity
B14_00707	COG3409	Peptidoglycan-binding domain 1 protein
B14_00707	COG0793	Belongs to the peptidase S41A family
B14_00709	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B14_00711	COG4897	Protein conserved in bacteria
B14_00712	COG0556	nucleotide-excision repair
B14_00713	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B14_00717	COG3595	metallopeptidase activity
B14_00718	COG1983	PspC domain protein
B14_00719	COG1950	PFAM Membrane protein of
B14_00720	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B14_00721	COG2814	Major facilitator Superfamily
B14_00722	COG1846	Transcriptional regulator
B14_00723	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B14_00724	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B14_00725	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B14_00726	COG0546	phosphoglycolate phosphatase activity
B14_00727	COG0110	maltose O-acetyltransferase activity
B14_00728	COG5297	Belongs to the glycosyl hydrolase family 6
B14_00729	COG4990	cell redox homeostasis
B14_00730	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B14_00731	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B14_00732	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B14_00733	COG0131	Imidazoleglycerol-phosphate dehydratase
B14_00734	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B14_00735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B14_00736	COG0107	imidazoleglycerol-phosphate synthase activity
B14_00737	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B14_00737	COG0140	phosphoribosyl-ATP diphosphatase activity
B14_00738	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B14_00739	COG0457	Tetratricopeptide repeat
B14_00740	COG0492	ferredoxin-NADP+ reductase activity
B14_00741	COG1051	belongs to the nudix hydrolase family
B14_00742	COG1660	Displays ATPase and GTPase activities
B14_00743	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B14_00744	COG1481	regulation of sporulation
B14_00745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B14_00746	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B14_00747	COG2732	(Barnase) inhibitor
B14_00749	COG0640	Transcriptional regulator
B14_00750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B14_00751	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B14_00752	COG0288	reversible hydration of carbon dioxide
B14_00753	COG0659	secondary active sulfate transmembrane transporter activity
B14_00754	COG1078	dGTPase activity
B14_00755	COG1694	Mazg nucleotide pyrophosphohydrolase
B14_00756	COG1611	Belongs to the LOG family
B14_00757	COG0740	serine-type endopeptidase activity
B14_00760	COG1621	beta-fructofuranosidase activity
B14_00761	COG1621	beta-fructofuranosidase activity
B14_00762	COG1902	pentaerythritol trinitrate reductase activity
B14_00763	COG1733	regulation of RNA biosynthetic process
B14_00765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B14_00768	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B14_00770	COG2271	Major facilitator Superfamily
B14_00771	COG2249	NAD(P)H dehydrogenase (quinone) activity
B14_00773	COG1396	sequence-specific DNA binding
B14_00774	COG3944	biosynthesis protein
B14_00775	COG0489	protein tyrosine kinase activity
B14_00776	COG1086	Polysaccharide biosynthesis protein
B14_00777	COG0438	transferase activity, transferring glycosyl groups
B14_00778	COG1215	transferase activity, transferring glycosyl groups
B14_00779	COG0438	transferase activity, transferring glycosyl groups
B14_00781	COG1216	Glycosyl transferase, family 2
B14_00782	COG5039	Polysaccharide pyruvyl transferase
B14_00783	COG1216	Glycosyl transferase, family 2
B14_00784	COG2244	polysaccharide biosynthetic process
B14_00785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B14_00786	COG0110	maltose O-acetyltransferase activity
B14_00787	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B14_00788	COG5039	Polysaccharide pyruvyl transferase
B14_00790	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B14_00791	COG1620	l-lactate permease
B14_00792	COG2186	Transcriptional regulator
B14_00793	COG0247	lactate metabolic process
B14_00794	COG1139	Iron-sulfur cluster binding protein
B14_00795	COG1556	Lactate utilization protein
B14_00799	COG1113	amino acid transport
B14_00800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B14_00801	COG2390	Transcriptional regulator
B14_00802	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B14_00803	COG0126	phosphoglycerate kinase activity
B14_00804	COG0149	triose-phosphate isomerase activity
B14_00805	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B14_00806	COG0148	phosphopyruvate hydratase activity
B14_00807	COG0693	protein deglycase activity
B14_00809	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B14_00811	COG4640	response to antibiotic
B14_00813	COG2095	MarC family integral membrane protein
B14_00814	COG1510	regulation of RNA biosynthetic process
B14_00815	COG1125	glycine betaine transport
B14_00815	COG0517	IMP dehydrogenase activity
B14_00816	COG1174	glycine betaine transport
B14_00817	COG1732	Glycine betaine
B14_00818	COG1174	glycine betaine transport
B14_00819	COG1396	sequence-specific DNA binding
B14_00820	COG1396	sequence-specific DNA binding
B14_00821	COG1476	TRANSCRIPTIONal
B14_00822	COG2002	toxin-antitoxin pair type II binding
B14_00823	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B14_00824	COG1647	Serine aminopeptidase, S33
B14_00825	COG0557	exoribonuclease II activity
B14_00826	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B14_00857	COG4626	Terminase
B14_00857	COG1802	Transcriptional regulator
B14_00870	COG3953	SLT domain
B14_00870	COG5280	Phage tail tape measure protein TP901
B14_00872	COG1705	Flagellar rod assembly protein muramidase FlgJ
B14_00881	COG5444	nuclease activity
B14_00889	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B14_00895	COG2140	Oxalate decarboxylase
B14_00897	COG1191	sigma factor activity
B14_00901	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B14_00902	COG0673	inositol 2-dehydrogenase activity
B14_00904	COG1846	Transcriptional regulator
B14_00906	COG2124	cytochrome p450
B14_00908	COG2814	Major facilitator Superfamily
B14_00909	COG2814	Major facilitator Superfamily
B14_00910	COG3347	Dehydrogenase
B14_00910	COG1028	Short-chain dehydrogenase reductase Sdr
B14_00912	COG4952	isomerase
B14_00913	COG1070	Carbohydrate kinase
B14_00914	COG1349	DNA-binding transcription factor activity
B14_00915	COG0693	protein deglycase activity
B14_00916	COG1937	Protein conserved in bacteria
B14_00917	COG2608	mercury ion transmembrane transporter activity
B14_00918	COG2217	Heavy metal translocating P-type atpase
B14_00922	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B14_00922	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B14_00922	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B14_00926	COG0803	Belongs to the bacterial solute-binding protein 9 family
B14_00927	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B14_00928	COG1121	(ABC) transporter
B14_00929	COG1472	Belongs to the glycosyl hydrolase 3 family
B14_00930	COG1501	Belongs to the glycosyl hydrolase 31 family
B14_00931	COG0395	ABC-type sugar transport system, permease component
B14_00932	COG1175	transmembrane transport
B14_00933	COG1653	transport
B14_00934	COG2217	Heavy metal translocating P-type atpase
B14_00935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B14_00936	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B14_00937	COG0456	acetyltransferase
B14_00939	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B14_00939	COG0456	acetyltransferase
B14_00940	COG2860	membrane
B14_00941	COG3973	AAA domain
B14_00943	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B14_00944	COG1940	carbohydrate kinase activity
B14_00945	COG0656	L-ascorbic acid biosynthetic process
B14_00946	COG2814	Major facilitator Superfamily
B14_00947	COG1368	sulfuric ester hydrolase activity
B14_00948	COG1988	membrane-bound metal-dependent
B14_00949	COG0531	amino acid
B14_00950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B14_00951	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B14_00952	COG1120	ATPase activity
B14_00953	COG0745	RESPONSE REGULATOR receiver
B14_00954	COG2205	protein histidine kinase activity
B14_00955	COG1904	glucuronate isomerase
B14_00956	COG2211	Major facilitator Superfamily
B14_00957	COG1609	Transcriptional regulator
B14_00958	COG0246	Mannitol dehydrogenase
B14_00959	COG2721	sulfolactate sulfo-lyase activity
B14_00961	COG0583	DNA-binding transcription factor activity
B14_00962	COG2258	MOSC domain
B14_00963	COG1028	Short-chain dehydrogenase reductase Sdr
B14_00964	COG1802	Transcriptional regulator
B14_00965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B14_00966	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B14_00967	COG1120	ATPase activity
B14_00968	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B14_00969	COG1454	alcohol dehydrogenase
B14_00970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B14_00971	COG1028	Short-chain dehydrogenase reductase Sdr
B14_00972	COG2096	Adenosyltransferase
B14_00973	COG4677	pectinesterase activity
B14_00974	COG4758	membrane
B14_00975	COG1842	Phage shock protein A
B14_00977	COG4758	membrane
B14_00978	COG4585	Histidine kinase
B14_00979	COG2197	response regulator
B14_00982	COG0814	amino acid
B14_00983	COG0697	spore germination
B14_00985	COG0114	fumarate hydratase activity
B14_00986	COG1309	transcriptional regulator
B14_00988	COG2205	protein histidine kinase activity
B14_00988	COG2770	Histidine kinase
B14_00989	COG0745	RESPONSE REGULATOR receiver
B14_00990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B14_00991	COG0783	Belongs to the Dps family
B14_00992	COG1028	Short-chain dehydrogenase reductase Sdr
B14_00993	COG1686	Belongs to the peptidase S11 family
B14_00996	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B14_00997	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B14_00998	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B14_00999	COG1120	ATPase activity
B14_01002	COG5577	PFAM Coat F domain
B14_01005	COG1250	3-hydroxyacyl-CoA dehydrogenase
B14_01005	COG1024	Enoyl-CoA hydratase
B14_01006	COG0183	Belongs to the thiolase family
B14_01007	COG1960	acyl-CoA dehydrogenase activity
B14_01008	COG1393	Belongs to the ArsC family
B14_01009	COG0509	glycine decarboxylation via glycine cleavage system
B14_01011	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B14_01012	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B14_01014	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B14_01015	COG2011	ABC-type metal ion transport system permease component
B14_01016	COG1464	Belongs to the NlpA lipoprotein family
B14_01017	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B14_01019	COG0396	ATPase activity
B14_01020	COG0719	Fe-S assembly protein
B14_01021	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B14_01022	COG0822	iron-sulfur transferase activity
B14_01023	COG0719	Fe-S assembly protein
B14_01024	COG0457	Tetratricopeptide repeat
B14_01028	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B14_01030	COG2356	endonuclease I
B14_01031	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B14_01032	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B14_01033	COG1288	antiporter activity
B14_01034	COG2814	Major facilitator Superfamily
B14_01035	COG2508	Transcriptional regulator
B14_01036	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B14_01037	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B14_01039	COG3226	Transcriptional regulator
B14_01041	COG1801	Protein of unknown function DUF72
B14_01042	COG0730	response to heat
B14_01043	COG0737	Belongs to the 5'-nucleotidase family
B14_01044	COG3377	Domain of unknown function (DUF1805)
B14_01046	COG0733	neurotransmitter:sodium symporter activity
B14_01048	COG0739	heme binding
B14_01051	COG4470	Protein conserved in bacteria
B14_01052	COG2445	Protein of unknown function DUF86
B14_01053	COG0647	UMP catabolic process
B14_01054	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B14_01055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B14_01057	COG0460	homoserine dehydrogenase
B14_01058	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B14_01059	COG0083	homoserine kinase activity
B14_01060	COG0823	Involved in the tonB-independent uptake of proteins
B14_01060	COG1506	peptidase
B14_01060	COG4946	Tricorn protease homolog
B14_01061	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B14_01062	COG4837	Protein of unknown function (DUF1462)
B14_01064	COG3479	Phenolic acid decarboxylase
B14_01065	COG0457	Tetratricopeptide repeat
B14_01067	COG5646	InterPro IPR014922
B14_01068	COG1252	NADH dehydrogenase
B14_01069	COG4844	belongs to the
B14_01070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B14_01071	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B14_01072	COG0316	Belongs to the HesB IscA family
B14_01073	COG0456	acetyltransferase
B14_01076	COG0492	ferredoxin-NADP+ reductase activity
B14_01077	COG1252	NADH dehydrogenase
B14_01079	COG3584	3D domain protein
B14_01080	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B14_01081	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B14_01082	COG2056	Na+-H+ antiporter family
B14_01083	COG1268	BioY protein
B14_01084	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B14_01086	COG0686	Belongs to the AlaDH PNT family
B14_01087	COG2508	Transcriptional regulator
B14_01087	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B14_01088	COG1115	amino acid carrier protein
B14_01089	COG4842	Belongs to the WXG100 family
B14_01090	COG5417	Belongs to the EsaB family
B14_01091	COG4499	WXG100 protein secretion system (Wss), protein YukC
B14_01092	COG1674	ftsk spoiiie
B14_01092	COG0433	COG0433 Predicted ATPase
B14_01093	COG1511	domain protein
B14_01095	COG1028	Short-chain dehydrogenase reductase Sdr
B14_01096	COG1418	mRNA catabolic process
B14_01099	COG1959	2 iron, 2 sulfur cluster binding
B14_01100	COG0628	permease
B14_01103	COG5506	Protein of unknown function (DUF1694)
B14_01104	COG1335	isochorismatase
B14_01105	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B14_01106	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B14_01110	COG0142	geranyltranstransferase activity
B14_01112	COG4585	Histidine kinase
B14_01113	COG2197	response regulator
B14_01114	COG2050	protein possibly involved in aromatic compounds catabolism
B14_01115	COG1320	monovalent cation:proton antiporter activity
B14_01116	COG2212	antiporter activity
B14_01117	COG1863	multisubunit Na H antiporter MnhE subunit
B14_01118	COG0651	ATP synthesis coupled electron transport
B14_01119	COG1006	Multisubunit Na H antiporter MnhC subunit
B14_01120	COG2111	Na H antiporter
B14_01121	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B14_01121	COG2111	Na H antiporter
B14_01123	COG3493	citrate carrier protein
B14_01124	COG0688	phosphatidylethanolamine metabolic process
B14_01125	COG0586	Pfam SNARE associated Golgi protein
B14_01126	COG1183	phosphatidylcholine synthase activity
B14_01127	COG4565	transcriptional regulatory protein
B14_01128	COG3290	protein histidine kinase activity
B14_01130	COG3011	Protein conserved in bacteria
B14_01131	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B14_01132	COG2814	Major facilitator Superfamily
B14_01133	COG5018	Exonuclease
B14_01136	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B14_01139	COG2267	carboxylic ester hydrolase activity
B14_01140	COG1522	sequence-specific DNA binding
B14_01141	COG0436	Aminotransferase
B14_01142	COG1098	S1 RNA binding domain
B14_01143	COG2155	Conserved Protein
B14_01144	COG1979	alcohol dehydrogenase
B14_01145	COG0166	Belongs to the GPI family
B14_01147	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B14_01148	COG2323	membrane
B14_01150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B14_01153	COG2738	Putative neutral zinc metallopeptidase
B14_01154	COG1253	flavin adenine dinucleotide binding
B14_01155	COG5297	Belongs to the glycosyl hydrolase family 6
B14_01158	COG0366	Alpha amylase catalytic
B14_01159	COG0432	Pfam Uncharacterised protein family UPF0047
B14_01160	COG2070	2-Nitropropane dioxygenase
B14_01162	COG0840	transmembrane signaling receptor activity
B14_01163	COG0840	transmembrane signaling receptor activity
B14_01164	COG0840	transmembrane signaling receptor activity
B14_01165	COG0693	protein deglycase activity
B14_01166	COG0673	inositol 2-dehydrogenase activity
B14_01167	COG0628	permease
B14_01168	COG1968	undecaprenyl-diphosphatase activity
B14_01169	COG1408	metallophosphoesterase
B14_01170	COG0726	polysaccharide deacetylase
B14_01171	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B14_01176	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
B14_01183	COG1397	ADP-ribosylglycohydrolase
B14_01189	COG2140	Oxalate decarboxylase
B14_01190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B14_01191	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B14_01193	COG1510	regulation of RNA biosynthetic process
B14_01195	COG1454	alcohol dehydrogenase
B14_01197	COG2318	DinB family
B14_01199	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B14_01200	COG0569	domain protein
B14_01201	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B14_01203	COG0457	Tetratricopeptide repeat
B14_01206	COG3764	Sortase (surface protein transpeptidase)
B14_01207	COG3859	Proton-coupled thiamine transporter YuaJ
B14_01208	COG1609	Transcriptional regulator
B14_01233	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B14_01234	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B14_01235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B14_01236	COG0297	glycogen (starch) synthase activity
B14_01237	COG0058	SHG alpha-glucan phosphorylase activity
B14_01238	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B14_01239	COG1575	Belongs to the MenA family. Type 1 subfamily
B14_01240	COG1169	isochorismate synthase
B14_01241	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B14_01242	COG0596	Alpha beta hydrolase
B14_01243	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B14_01244	COG0318	PFAM AMP-dependent synthetase and ligase
B14_01245	COG4948	Mandelate Racemase Muconate Lactonizing
B14_01248	COG1294	oxidase, subunit
B14_01249	COG1271	oxidase subunit
B14_01250	COG0254	rRNA binding
B14_01251	COG0803	Belongs to the bacterial solute-binding protein 9 family
B14_01252	COG0523	cobalamin synthesis protein
B14_01253	COG0288	reversible hydration of carbon dioxide
B14_01254	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B14_01255	COG1854	S-ribosylhomocysteine lyase activity
B14_01258	COG0783	Belongs to the Dps family
B14_01259	COG4824	toxin secretion phage lysis holin
B14_01261	COG0494	nUDIX hydrolase
B14_01262	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B14_01263	COG1116	anion transmembrane transporter activity
B14_01264	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B14_01265	COG1506	peptidase
B14_01268	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B14_01269	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B14_01270	COG0367	asparagine synthase
B14_01271	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B14_01271	COG0438	transferase activity, transferring glycosyl groups
B14_01272	COG0671	phosphoesterase, PA-phosphatase related
B14_01273	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B14_01274	COG2267	carboxylic ester hydrolase activity
B14_01276	COG1301	dicarboxylic acid transport
B14_01277	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B14_01278	COG1242	4 iron, 4 sulfur cluster binding
B14_01281	COG1725	Transcriptional regulator
B14_01282	COG1131	(ABC) transporter
B14_01284	COG1136	(ABC) transporter
B14_01285	COG0577	efflux transmembrane transporter activity
B14_01286	COG2433	Pfam Transposase IS66
B14_01289	COG2814	Major facilitator Superfamily
B14_01291	COG0495	leucyl-tRNA aminoacylation
B14_01292	COG0346	lactoylglutathione lyase activity
B14_01293	COG0583	DNA-binding transcription factor activity
B14_01295	COG1073	alpha beta
B14_01296	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B14_01297	COG0395	ABC-type sugar transport system, permease component
B14_01298	COG1653	transport
B14_01299	COG2207	Transcriptional regulator
B14_01300	COG4209	transmembrane transport
B14_01301	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B14_01302	COG1653	transport
B14_01303	COG0673	inositol 2-dehydrogenase activity
B14_01304	COG5578	integral membrane protein
B14_01306	COG0457	Tetratricopeptide repeat
B14_01308	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B14_01310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B14_01311	COG2081	HI0933 family
B14_01312	COG2244	polysaccharide biosynthetic process
B14_01313	COG1187	pseudouridine synthase activity
B14_01314	COG1349	DNA-binding transcription factor activity
B14_01315	COG2252	PERMEase
B14_01316	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B14_01319	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B14_01320	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B14_01322	COG1597	lipid kinase activity
B14_01323	COG1523	belongs to the glycosyl hydrolase 13 family
B14_01325	COG0510	thiamine kinase activity
B14_01327	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B14_01328	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B14_01329	COG0281	malic enzyme
B14_01330	COG5584	Small secreted protein
B14_01331	COG1363	Peptidase, m42
B14_01333	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B14_01334	COG4848	Belongs to the UPF0354 family
B14_01335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B14_01336	COG1674	ftsk spoiiie
B14_01337	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B14_01338	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B14_01339	COG4980	gas vesicle protein
B14_01340	COG3118	belongs to the thioredoxin family
B14_01343	COG1605	Chorismate mutase
B14_01343	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B14_01344	COG1609	Transcriptional regulator
B14_01345	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B14_01346	COG1360	Flagellar Motor Protein
B14_01347	COG0123	including yeast histone deacetylase and acetoin utilization protein
B14_01348	COG0517	IMP dehydrogenase activity
B14_01349	COG0454	-acetyltransferase
B14_01350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B14_01351	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B14_01353	COG1522	sequence-specific DNA binding
B14_01354	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B14_01355	COG3152	Membrane
B14_01358	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B14_01359	COG2203	Gaf domain
B14_01359	COG2199	diguanylate cyclase activity
B14_01360	COG1956	GAF domain-containing protein
B14_01361	COG1309	transcriptional regulator
B14_01362	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B14_01363	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B14_01364	COG1114	Component of the transport system for branched-chain amino acids
B14_01365	COG1104	cysteine desulfurase activity
B14_01366	COG0301	tRNA thio-modification
B14_01368	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B14_01370	COG0477	Major facilitator Superfamily
B14_01371	COG1566	PFAM secretion protein HlyD family protein
B14_01372	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B14_01373	COG0616	signal peptide processing
B14_01374	COG1714	RDD family
B14_01376	COG3874	Sporulation protein YtfJ
B14_01377	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B14_01378	COG0827	DNA restriction-modification system
B14_01379	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B14_01380	COG0521	Mo-molybdopterin cofactor biosynthetic process
B14_01381	COG0137	argininosuccinate synthase activity
B14_01382	COG0165	Argininosuccinate lyase
B14_01384	COG1028	Short-chain dehydrogenase reductase Sdr
B14_01385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B14_01386	COG1695	Transcriptional regulator
B14_01387	COG4109	DRTGG domain
B14_01389	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B14_01393	COG0587	DNA-directed DNA polymerase activity
B14_01394	COG0281	malic enzyme
B14_01395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B14_01396	COG0825	malonyl-CoA metabolic process
B14_01397	COG0205	6-phosphofructokinase activity
B14_01399	COG3030	protein affecting phage T7 exclusion by the F plasmid
B14_01400	COG0628	permease
B14_01401	COG2707	UPF0756 membrane protein
B14_01402	COG0372	Belongs to the citrate synthase family
B14_01403	COG0538	isocitrate dehydrogenase activity
B14_01404	COG0039	L-malate dehydrogenase activity
B14_01405	COG0745	RESPONSE REGULATOR receiver
B14_01406	COG5002	protein histidine kinase activity
B14_01407	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B14_01407	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B14_01408	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B14_01409	COG1971	Probably functions as a manganese efflux pump
B14_01410	COG0237	dephospho-CoA kinase activity
B14_01411	COG3866	Pectate lyase
B14_01412	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B14_01413	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B14_01415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B14_01416	COG3611	Membrane attachment protein
B14_01417	COG1484	DNA-dependent DNA replication
B14_01418	COG0398	Pfam SNARE associated Golgi protein
B14_01420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B14_01423	COG3275	phosphorelay sensor kinase activity
B14_01424	COG3279	Response regulator of the LytR AlgR family
B14_01425	COG3540	Alkaline phosphatase
B14_01427	COG1346	cytolysis
B14_01428	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B14_01429	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B14_01430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B14_01431	COG3326	Membrane
B14_01433	COG1363	Peptidase, m42
B14_01434	COG3507	Belongs to the glycosyl hydrolase 43 family
B14_01435	COG2160	L-arabinose isomerase activity
B14_01436	COG1069	ribulokinase activity
B14_01437	COG0235	Class ii aldolase
B14_01438	COG0371	Dehydrogenase
B14_01439	COG1653	transport
B14_01440	COG1175	transmembrane transport
B14_01441	COG0395	ABC-type sugar transport system, permease component
B14_01444	COG1966	Carbon starvation protein
B14_01445	COG1966	Carbon starvation protein
B14_01447	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B14_01448	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B14_01449	COG0072	phenylalanine-tRNA ligase activity
B14_01449	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B14_01452	COG1137	ATPase activity
B14_01456	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B14_01457	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B14_01458	COG1286	toxin biosynthetic process
B14_01459	COG1796	DNA polymerase
B14_01459	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B14_01460	COG1193	negative regulation of DNA recombination
B14_01461	COG3766	membrane
B14_01462	COG0318	PFAM AMP-dependent synthetase and ligase
B14_01463	COG1309	transcriptional regulator
B14_01464	COG1024	Enoyl-CoA hydratase
B14_01465	COG2086	electron transfer activity
B14_01466	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B14_01467	COG3118	belongs to the thioredoxin family
B14_01468	COG0322	excinuclease ABC activity
B14_01469	COG0527	aspartate kinase activity
B14_01470	COG1719	4-vinyl reductase, 4VR
B14_01471	COG2009	succinate dehydrogenase
B14_01472	COG1053	succinate dehydrogenase
B14_01473	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B14_01474	COG0824	Thioesterase
B14_01475	COG4221	oxidoreductase activity
B14_01476	COG2197	response regulator
B14_01477	COG1846	Transcriptional regulator
B14_01478	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B14_01479	COG5401	PFAM Sporulation and spore germination
B14_01480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B14_01481	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B14_01482	COG0622	Phosphoesterase
B14_01487	COG0457	Tetratricopeptide repeat
B14_01488	COG5444	nuclease activity
B14_01492	COG0270	DNA (cytosine-5-)-methyltransferase activity
B14_01497	COG1783	phage Terminase large subunit
B14_01498	COG5518	Phage portal protein
B14_01501	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B14_01503	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B14_01504	COG0028	Belongs to the TPP enzyme family
B14_01505	COG0440	acetolactate synthase activity
B14_01506	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B14_01507	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B14_01508	COG0473	3-isopropylmalate dehydrogenase activity
B14_01509	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B14_01510	COG0066	3-isopropylmalate dehydratase activity
B14_01511	COG0457	Tetratricopeptide repeat
B14_01511	COG1477	protein flavinylation
B14_01512	COG0544	peptidyl-prolyl cis-trans isomerase activity
B14_01513	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B14_01514	COG0470	DNA polymerase III
B14_01514	COG1067	ATP-dependent peptidase activity
B14_01515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B14_01516	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B14_01518	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B14_01519	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B14_01520	COG0181	hydroxymethylbilane synthase activity
B14_01521	COG1587	Uroporphyrinogen-III synthase
B14_01522	COG0113	porphobilinogen synthase activity
B14_01523	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B14_01524	COG1388	LysM domain
B14_01525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B14_01527	COG0525	valine-tRNA ligase activity
B14_01528	COG0285	dihydrofolate synthase activity
B14_01529	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B14_01531	COG0424	maF-like protein
B14_01532	COG2003	Belongs to the UPF0758 family
B14_01533	COG1077	Cell shape determining protein MreB Mrl
B14_01534	COG1792	Involved in formation and maintenance of cell shape
B14_01535	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B14_01536	COG0850	regulation of cytokinetic process
B14_01537	COG2894	cell division
B14_01538	COG0640	Transcriptional regulator
B14_01539	COG3832	glyoxalase III activity
B14_01540	COG0739	heme binding
B14_01541	COG1994	Peptidase M50
B14_01542	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B14_01543	COG2868	ribosomal protein
B14_01544	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B14_01545	COG3290	protein histidine kinase activity
B14_01546	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B14_01547	COG4492	Belongs to the UPF0735 family
B14_01548	COG0077	Prephenate dehydratase
B14_01549	COG1827	regulation of RNA biosynthetic process
B14_01550	COG1104	cysteine desulfurase activity
B14_01551	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B14_01552	COG0157	Belongs to the NadC ModD family
B14_01553	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B14_01554	COG1388	LysM domain
B14_01556	COG0217	transcriptional regulatory protein
B14_01559	COG4195	phage-related replication protein
B14_01560	COG2318	DinB family
B14_01563	COG2112	serine threonine protein kinase
B14_01565	COG0632	four-way junction helicase activity
B14_01566	COG2255	four-way junction helicase activity
B14_01568	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B14_01569	COG0343	queuine tRNA-ribosyltransferase activity
B14_01570	COG1862	Preprotein translocase
B14_01572	COG2323	membrane
B14_01573	COG2244	polysaccharide biosynthetic process
B14_01575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B14_01575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B14_01576	COG5416	Lipopolysaccharide assembly protein A domain
B14_01577	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B14_01577	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B14_01578	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B14_01579	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B14_01580	COG1490	D-aminoacyl-tRNA deacylase activity
B14_01581	COG4991	sh3 domain protein
B14_01581	COG3103	Sh3 type 3 domain protein
B14_01581	COG0860	N-Acetylmuramoyl-L-alanine amidase
B14_01583	COG0124	histidyl-tRNA synthetase
B14_01584	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B14_01585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B14_01586	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B14_01587	COG1959	2 iron, 2 sulfur cluster binding
B14_01588	COG1104	cysteine desulfurase activity
B14_01589	COG0482	sulfurtransferase activity
B14_01590	COG0457	Tetratricopeptide repeat
B14_01591	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B14_01592	COG3881	PFAM PRC-barrel domain
B14_01594	COG0628	permease
B14_01595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B14_01596	COG4472	Bacterial protein of unknown function (DUF965)
B14_01597	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B14_01598	COG3906	Belongs to the UPF0473 family
B14_01599	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B14_01603	COG0572	uridine kinase
B14_01604	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B14_01605	COG0768	penicillin binding
B14_01608	COG2226	methyltransferase
B14_01609	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B14_01610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B14_01611	COG0626	cystathionine gamma-synthase activity
B14_01615	COG2226	methyltransferase
B14_01616	COG1404	Belongs to the peptidase S8 family
B14_01617	COG1309	transcriptional regulator
B14_01618	COG2124	cytochrome p450
B14_01618	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B14_01620	COG2814	Major facilitator Superfamily
B14_01621	COG0583	DNA-binding transcription factor activity
B14_01622	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B14_01624	COG1587	Uroporphyrinogen-III synthase
B14_01625	COG3340	Belongs to the peptidase S51 family
B14_01626	COG1733	regulation of RNA biosynthetic process
B14_01627	COG2814	Major facilitator Superfamily
B14_01628	COG0656	L-ascorbic acid biosynthetic process
B14_01629	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B14_01630	COG2169	Transcriptional regulator
B14_01634	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B14_01634	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B14_01635	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B14_01636	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_01637	COG3715	PTS system
B14_01638	COG3716	PTS system mannose fructose sorbose family IID component
B14_01639	COG1621	beta-fructofuranosidase activity
B14_01640	COG1028	Short-chain dehydrogenase reductase Sdr
B14_01642	COG0730	response to heat
B14_01643	COG2124	cytochrome p450
B14_01646	COG1028	Short-chain dehydrogenase reductase Sdr
B14_01650	COG4608	Belongs to the ABC transporter superfamily
B14_01651	COG0444	Belongs to the ABC transporter superfamily
B14_01653	COG0601	transmembrane transport
B14_01654	COG0747	negative chemotaxis
B14_01655	COG0492	ferredoxin-NADP+ reductase activity
B14_01656	COG2197	response regulator
B14_01657	COG4585	Histidine kinase
B14_01658	COG3239	Fatty acid desaturase
B14_01659	COG1733	regulation of RNA biosynthetic process
B14_01660	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B14_01661	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B14_01663	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B14_01667	COG1937	Protein conserved in bacteria
B14_01668	COG2210	Belongs to the sulfur carrier protein TusA family
B14_01669	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B14_01669	COG0425	Belongs to the sulfur carrier protein TusA family
B14_01670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B14_01670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B14_01671	COG0425	Belongs to the sulfur carrier protein TusA family
B14_01672	COG0730	response to heat
B14_01673	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B14_01674	COG4585	Histidine kinase
B14_01675	COG2197	response regulator
B14_01688	COG0860	N-Acetylmuramoyl-L-alanine amidase
B14_01695	COG2427	Protein of unknown function (DUF1641)
B14_01696	COG3383	formate dehydrogenase (NAD+) activity
B14_01697	COG5609	conserved protein (DUF2294)
B14_01698	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B14_01699	COG2755	lipolytic protein G-D-S-L family
B14_01701	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B14_01702	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B14_01703	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B14_01704	COG1534	Rna-binding protein
B14_01705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B14_01706	COG1713	HD superfamily hydrolase involved in NAD metabolism
B14_01707	COG0799	negative regulation of ribosome biogenesis
B14_01708	COG2226	methyltransferase
B14_01709	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B14_01710	COG1596	polysaccharide export
B14_01710	COG1555	photosystem II stabilization
B14_01711	COG2131	deaminase
B14_01712	COG0658	competence protein
B14_01712	COG2333	competence protein COMEC
B14_01714	COG1466	dna polymerase III delta subunit
B14_01715	COG0268	Binds directly to 16S ribosomal RNA
B14_01716	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B14_01717	COG0860	N-Acetylmuramoyl-L-alanine amidase
B14_01719	COG0481	GTPase activity
B14_01720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B14_01721	COG1420	regulation of RNA biosynthetic process
B14_01722	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B14_01723	COG0443	Heat shock 70 kDa protein
B14_01724	COG0484	heat shock protein binding
B14_01725	COG2264	protein methyltransferase activity
B14_01726	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B14_01727	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B14_01728	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B14_01729	COG1283	sodium-dependent phosphate transmembrane transporter activity
B14_01730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B14_01731	COG1610	YqeY-like protein
B14_01732	COG1030	water channel activity
B14_01733	COG4864	UPF0365 protein
B14_01736	COG0561	phosphatase activity
B14_01737	COG1702	phosphate starvation-inducible protein PhoH
B14_01738	COG1480	7TM receptor with intracellular HD hydrolase
B14_01739	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B14_01740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B14_01741	COG0295	cytidine deaminase activity
B14_01742	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B14_01744	COG1381	Involved in DNA repair and RecF pathway recombination
B14_01745	COG0752	glycyl-tRNA synthetase alpha subunit
B14_01746	COG0751	glycine-tRNA ligase activity
B14_01747	COG0517	IMP dehydrogenase activity
B14_01748	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B14_01749	COG1671	Belongs to the UPF0178 family
B14_01750	COG0358	DNA primase activity
B14_01751	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B14_01752	COG2010	Cytochrome c
B14_01755	COG5444	nuclease activity
B14_01766	COG2384	SAM-dependent methyltransferase
B14_01767	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B14_01768	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B14_01770	COG0513	Belongs to the DEAD box helicase family
B14_01771	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B14_01773	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B14_01774	COG1121	(ABC) transporter
B14_01775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B14_01776	COG0735	belongs to the Fur family
B14_01777	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
B14_01778	COG4709	membrane
B14_01779	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B14_01780	COG1388	LysM domain
B14_01781	COG5521	maltodextrose utilization protein MalA
B14_01782	COG2839	Protein conserved in bacteria
B14_01783	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B14_01784	COG0477	Major facilitator Superfamily
B14_01786	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B14_01787	COG0573	inorganic phosphate transmembrane transporter activity
B14_01788	COG0581	inorganic phosphate transmembrane transporter activity
B14_01789	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B14_01790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B14_01791	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B14_01794	COG0438	transferase activity, transferring glycosyl groups
B14_01795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B14_01796	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B14_01798	COG0705	Rhomboid family
B14_01798	COG0457	Tetratricopeptide repeat
B14_01799	COG0697	spore germination
B14_01800	COG1940	carbohydrate kinase activity
B14_01801	COG1368	sulfuric ester hydrolase activity
B14_01803	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B14_01804	COG2866	Carboxypeptidase
B14_01806	COG0011	TIGRFAM Protein of
B14_01808	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B14_01810	COG1393	Belongs to the ArsC family
B14_01812	COG1366	Belongs to the anti-sigma-factor antagonist family
B14_01813	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B14_01814	COG1459	type II secretion system
B14_01815	COG4537	Required for transformation and DNA binding
B14_01816	COG4970	Tfp pilus assembly protein FimT
B14_01817	COG4940	Competence protein ComGF
B14_01822	COG0681	Belongs to the peptidase S26 family
B14_01827	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B14_01828	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B14_01829	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B14_01830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B14_01831	COG4175	Glycine betaine
B14_01831	COG0517	IMP dehydrogenase activity
B14_01832	COG4176	ABC-type proline glycine betaine transport system permease component
B14_01833	COG2113	Glycine betaine
B14_01834	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B14_01835	COG0095	Lipoate-protein ligase
B14_01836	COG1321	iron dependent repressor
B14_01837	COG1752	Esterase of the alpha-beta hydrolase superfamily
B14_01839	COG3872	metal-dependent enzyme
B14_01841	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B14_01842	COG0006	proline dipeptidase activity
B14_01843	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B14_01845	COG3854	ATPases associated with a variety of cellular activities
B14_01853	COG0511	ligase activity, forming carbon-carbon bonds
B14_01854	COG0439	Biotin carboxylase
B14_01855	COG1302	Protein conserved in bacteria
B14_01856	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B14_01857	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B14_01858	COG1570	exodeoxyribonuclease VII activity
B14_01859	COG1722	exodeoxyribonuclease VII activity
B14_01860	COG0142	geranyltranstransferase activity
B14_01861	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B14_01862	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B14_01863	COG1438	arginine binding
B14_01864	COG0497	DNA recombination
B14_01865	COG0750	zinc metalloprotease
B14_01866	COG0745	RESPONSE REGULATOR receiver
B14_01868	COG1045	serine acetyltransferase
B14_01871	COG0860	N-Acetylmuramoyl-L-alanine amidase
B14_01872	COG0584	glycerophosphoryl diester phosphodiesterase
B14_01874	COG3829	transcription factor binding
B14_01874	COG3290	protein histidine kinase activity
B14_01875	COG0280	phosphate acetyltransferase
B14_01877	COG3426	butyrate kinase activity
B14_01878	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B14_01879	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B14_01880	COG0022	dehydrogenase e1 component
B14_01881	COG0508	dehydrogenase complex catalyzes the overall conversion of
B14_01882	COG1597	lipid kinase activity
B14_01885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B14_01886	COG0765	amino acid transport
B14_01887	COG1126	abc transporter atp-binding protein
B14_01888	COG4129	membrane
B14_01889	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B14_01890	COG2195	Cleaves the N-terminal amino acid of tripeptides
B14_01891	COG0706	membrane insertase activity
B14_01893	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B14_01894	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B14_01895	COG1028	Short-chain dehydrogenase reductase Sdr
B14_01896	COG1785	Belongs to the alkaline phosphatase family
B14_01897	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B14_01898	COG1447	Phosphotransferase system cellobiose-specific component IIA
B14_01899	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B14_01900	COG2723	6-phospho-beta-galactosidase activity
B14_01901	COG2188	Transcriptional regulator
B14_01905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B14_01906	COG1234	tRNA 3'-trailer cleavage
B14_01907	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B14_01908	COG0596	Alpha beta hydrolase
B14_01909	COG1902	pentaerythritol trinitrate reductase activity
B14_01910	COG4187	Peptidase family M20/M25/M40
B14_01911	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B14_01912	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B14_01913	COG0300	oxidoreductase activity
B14_01914	COG4195	phage-related replication protein
B14_01920	COG1072	(Pantothenic acid kinase))
B14_01921	COG0346	lactoylglutathione lyase activity
B14_01922	COG2211	Major facilitator Superfamily
B14_01924	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B14_01928	COG0534	Mate efflux family protein
B14_01930	COG0444	Belongs to the ABC transporter superfamily
B14_01932	COG0601	transmembrane transport
B14_01933	COG0747	negative chemotaxis
B14_01935	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B14_01936	COG2329	Antibiotic biosynthesis monooxygenase
B14_01938	COG0456	acetyltransferase
B14_01938	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B14_01940	COG4918	Iron-sulphur cluster biosynthesis
B14_01942	COG1073	alpha beta
B14_01944	COG0667	Aldo Keto reductase
B14_01946	COG1309	transcriptional regulator
B14_01948	COG0494	nUDIX hydrolase
B14_01949	COG1379	DNA repair
B14_01950	COG2153	protein acetylation
B14_01953	COG1953	Uracil, thiamine, allantoin
B14_01954	COG1953	Uracil, thiamine, allantoin
B14_01956	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B14_01957	COG1300	Membrane
B14_01958	COG0735	belongs to the Fur family
B14_01960	COG4974	Belongs to the 'phage' integrase family
B14_01961	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B14_01962	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B14_01963	COG1686	Belongs to the peptidase S11 family
B14_01970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B14_01973	COG0697	spore germination
B14_01975	COG0019	diaminopimelate decarboxylase activity
B14_01976	COG4195	phage-related replication protein
B14_01977	COG4086	secreted protein
B14_01978	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B14_01979	COG0457	Tetratricopeptide repeat
B14_01984	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B14_01984	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B14_01985	COG0307	riboflavin synthase, alpha
B14_01986	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B14_01986	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B14_01987	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B14_01988	COG0456	acetyltransferase
B14_01989	COG1547	Domain of unknown function (DUF309)
B14_01991	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B14_01992	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B14_01994	COG1686	Belongs to the peptidase S11 family
B14_01995	COG2715	membrane protein required for spore maturation
B14_01996	COG0700	Nucleoside recognition
B14_01997	COG1187	pseudouridine synthase activity
B14_01998	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B14_01999	COG1333	cytochrome c biogenesis protein
B14_02000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B14_02001	COG0745	RESPONSE REGULATOR receiver
B14_02002	COG5002	protein histidine kinase activity
B14_02003	COG0745	RESPONSE REGULATOR receiver
B14_02004	COG5002	protein histidine kinase activity
B14_02009	COG1595	DNA-templated transcription, initiation
B14_02011	COG0739	heme binding
B14_02012	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B14_02013	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B14_02014	COG1141	Ferredoxin
B14_02015	COG4955	Helix-turn-helix domain
B14_02016	COG0514	ATP-dependent DNA helicase (RecQ)
B14_02017	COG1266	CAAX protease self-immunity
B14_02018	COG1388	LysM domain
B14_02020	COG1408	metallophosphoesterase
B14_02021	COG4862	establishment of competence for transformation
B14_02022	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B14_02023	COG0492	ferredoxin-NADP+ reductase activity
B14_02025	COG2339	peptidase activity
B14_02026	COG3773	Cell wall hydrolase
B14_02026	COG3409	Peptidoglycan-binding domain 1 protein
B14_02027	COG2959	enzyme of heme biosynthesis
B14_02029	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B14_02030	COG0539	negative regulation of cytoplasmic translation
B14_02031	COG1304	FMN binding
B14_02036	COG1160	GTP binding
B14_02037	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B14_02041	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B14_02042	COG0776	regulation of translation
B14_02045	COG0142	geranyltranstransferase activity
B14_02046	COG2226	methyltransferase
B14_02047	COG0142	geranyltranstransferase activity
B14_02048	COG0105	UTP biosynthetic process
B14_02049	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B14_02050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B14_02051	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B14_02052	COG4401	Chorismate mutase type I
B14_02053	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B14_02054	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B14_02055	COG0134	indole-3-glycerol-phosphate synthase activity
B14_02056	COG0135	phosphoribosylanthranilate isomerase activity
B14_02057	COG0133	tryptophan synthase activity
B14_02058	COG0159	tryptophan synthase activity
B14_02059	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B14_02060	COG0287	Prephenate dehydrogenase
B14_02061	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B14_02062	COG0457	Tetratricopeptide repeat
B14_02063	COG5582	Belongs to the UPF0302 family
B14_02065	COG0723	plastoquinol--plastocyanin reductase activity
B14_02066	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B14_02067	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B14_02067	COG2010	Cytochrome c
B14_02068	COG4347	Protein of unknown function (DUF1405)
B14_02070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B14_02071	COG1694	Mazg nucleotide pyrophosphohydrolase
B14_02072	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B14_02073	COG1803	Methylglyoxal synthase
B14_02074	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B14_02075	COG0438	transferase activity, transferring glycosyl groups
B14_02076	COG0617	tRNA 3'-terminal CCA addition
B14_02078	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B14_02079	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B14_02080	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B14_02081	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B14_02081	COG1199	ATP-dependent helicase activity
B14_02083	COG5353	protein conserved in bacteria
B14_02084	COG0436	Aminotransferase
B14_02085	COG0017	Asparaginyl-tRNA synthetase
B14_02086	COG3935	DnaD domain protein
B14_02087	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B14_02089	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B14_02089	COG4499	WXG100 protein secretion system (Wss), protein YukC
B14_02090	COG3331	DNA recombination
B14_02096	COG0071	Belongs to the small heat shock protein (HSP20) family
B14_02097	COG2190	(PTS) system
B14_02098	COG1205	dead DEAH box helicase
B14_02098	COG1111	helicase
B14_02099	COG3359	exonuclease
B14_02102	COG4474	Belongs to the UPF0398 family
B14_02103	COG3599	regulation of cell shape
B14_02104	COG0116	Belongs to the methyltransferase superfamily
B14_02107	COG1199	ATP-dependent helicase activity
B14_02108	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B14_02109	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B14_02110	COG2233	PERMEase
B14_02111	COG0456	acetyltransferase
B14_02112	COG3424	synthase
B14_02113	COG1755	Isoprenylcysteine carboxyl methyltransferase
B14_02114	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B14_02117	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B14_02118	COG0328	RNA-DNA hybrid ribonuclease activity
B14_02119	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B14_02120	COG0328	RNA-DNA hybrid ribonuclease activity
B14_02124	COG1278	Cold shock
B14_02126	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B14_02127	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B14_02128	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B14_02129	COG0386	Belongs to the glutathione peroxidase family
B14_02130	COG1418	mRNA catabolic process
B14_02131	COG1413	lyase activity
B14_02132	COG0129	dihydroxy-acid dehydratase activity
B14_02134	COG2136	Putative SAM-dependent methyltransferase
B14_02134	COG2521	methyltransferase
B14_02136	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B14_02137	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B14_02138	COG0204	Acyl-transferase
B14_02139	COG1272	protein, Hemolysin III
B14_02140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B14_02141	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B14_02144	COG1999	signal sequence binding
B14_02145	COG2755	lipolytic protein G-D-S-L family
B14_02146	COG4698	Protein conserved in bacteria
B14_02149	COG0534	Mate efflux family protein
B14_02150	COG3706	GGDEF domain
B14_02152	COG1846	Transcriptional regulator
B14_02153	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B14_02154	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B14_02155	COG0456	acetyltransferase
B14_02157	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B14_02158	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B14_02159	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B14_02160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B14_02161	COG0456	acetyltransferase
B14_02162	COG1509	lysine 2,3-aminomutase activity
B14_02164	COG4479	Belongs to the UPF0346 family
B14_02168	COG0671	phosphoesterase, PA-phosphatase related
B14_02172	COG0701	Predicted permease
B14_02173	COG0813	purine-nucleoside phosphorylase activity
B14_02174	COG1876	peptidase activity
B14_02176	COG2226	methyltransferase
B14_02177	COG3409	Peptidoglycan-binding domain 1 protein
B14_02177	COG0793	Belongs to the peptidase S41A family
B14_02178	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B14_02180	COG0400	carboxylic ester hydrolase activity
B14_02181	COG0778	Nitroreductase
B14_02182	COG1733	regulation of RNA biosynthetic process
B14_02184	COG1028	Short-chain dehydrogenase reductase Sdr
B14_02186	COG4305	rare lipoprotein A
B14_02189	COG2962	Rard protein
B14_02191	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B14_02192	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B14_02193	COG0534	Mate efflux family protein
B14_02194	COG1388	LysM domain
B14_02194	COG0791	NLP P60 protein
B14_02195	COG2032	superoxide dismutase activity
B14_02196	COG0714	Associated with various cellular activities
B14_02197	COG4548	von Willebrand factor, type A
B14_02198	COG0567	Dehydrogenase, E1 component
B14_02199	COG0508	dehydrogenase complex catalyzes the overall conversion of
B14_02200	COG0385	Bile acid
B14_02201	COG0733	neurotransmitter:sodium symporter activity
B14_02203	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B14_02204	COG1657	PFAM Prenyltransferase squalene oxidase
B14_02207	COG2814	Major facilitator Superfamily
B14_02208	COG1012	belongs to the aldehyde dehydrogenase family
B14_02211	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B14_02212	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B14_02213	COG2318	DinB family
B14_02216	COG1309	transcriptional regulator
B14_02217	COG3848	Pyruvate phosphate dikinase
B14_02217	COG0574	Belongs to the PEP-utilizing enzyme family
B14_02219	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B14_02220	COG1280	lysine exporter protein (LysE YggA)
B14_02223	COG2267	carboxylic ester hydrolase activity
B14_02226	COG0402	S-adenosylhomocysteine deaminase activity
B14_02236	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B14_02239	COG3383	formate dehydrogenase (NAD+) activity
B14_02240	COG2427	Protein of unknown function (DUF1641)
B14_02242	COG2315	Protein conserved in bacteria
B14_02247	COG0514	ATP-dependent DNA helicase (RecQ)
B14_02248	COG3584	3D domain protein
B14_02248	COG1388	LysM domain
B14_02249	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B14_02252	COG2322	membrane
B14_02256	COG1086	Polysaccharide biosynthesis protein
B14_02257	COG0741	lytic transglycosylase activity
B14_02258	COG0531	amino acid
B14_02260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B14_02261	COG0640	Transcriptional regulator
B14_02263	COG2378	regulation of single-species biofilm formation
B14_02265	COG3708	Transcriptional regulator
B14_02266	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B14_02267	COG1309	transcriptional regulator
B14_02273	COG1846	Transcriptional regulator
B14_02274	COG1309	transcriptional regulator
B14_02276	COG1404	Belongs to the peptidase S8 family
B14_02277	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B14_02278	COG0840	transmembrane signaling receptor activity
B14_02280	COG0697	spore germination
B14_02281	COG0531	amino acid
B14_02282	COG0531	amino acid
B14_02284	COG0531	amino acid
B14_02285	COG2814	Major facilitator Superfamily
B14_02286	COG2814	Major facilitator Superfamily
B14_02287	COG1846	Transcriptional regulator
B14_02288	COG0243	molybdopterin cofactor binding
B14_02289	COG0477	Major facilitator Superfamily
B14_02290	COG0574	Belongs to the PEP-utilizing enzyme family
B14_02290	COG3848	Pyruvate phosphate dikinase
B14_02291	COG0300	oxidoreductase activity
B14_02293	COG1132	(ABC) transporter
B14_02295	COG1846	Transcriptional regulator
B14_02299	COG0583	DNA-binding transcription factor activity
B14_02300	COG0069	glutamate synthase activity
B14_02300	COG0070	glutamate synthase
B14_02300	COG0067	glutamate synthase
B14_02301	COG0493	'glutamate synthase
B14_02304	COG0463	Glycosyl transferase, family 2
B14_02305	COG2814	Major facilitator Superfamily
B14_02306	COG4948	Mandelate Racemase Muconate Lactonizing
B14_02307	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B14_02308	COG1809	phosphosulfolactate synthase activity
B14_02309	COG0175	sulfate reduction
B14_02310	COG0306	phosphate transporter
B14_02311	COG2323	membrane
B14_02314	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B14_02315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B14_02316	COG1733	regulation of RNA biosynthetic process
B14_02317	COG2249	NAD(P)H dehydrogenase (quinone) activity
B14_02318	COG1960	acyl-CoA dehydrogenase activity
B14_02319	COG0318	PFAM AMP-dependent synthetase and ligase
B14_02320	COG0439	Biotin carboxylase
B14_02321	COG0511	ligase activity, forming carbon-carbon bonds
B14_02322	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B14_02323	COG1024	Enoyl-CoA hydratase
B14_02324	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B14_02325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B14_02327	COG0166	Belongs to the GPI family
B14_02330	COG1252	NADH dehydrogenase
B14_02331	COG2027	D-alanyl-D-alanine carboxypeptidase
B14_02333	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B14_02334	COG2404	hydrolase activity, acting on ester bonds
B14_02335	COG1649	PFAM Uncharacterised BCR, COG1649
B14_02338	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B14_02339	COG0640	Transcriptional regulator
B14_02340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B14_02341	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B14_02342	COG1609	Transcriptional regulator
B14_02344	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B14_02347	COG1312	Catalyzes the dehydration of D-mannonate
B14_02348	COG1028	Short-chain dehydrogenase reductase Sdr
B14_02349	COG1725	Transcriptional regulator
B14_02352	COG3711	transcriptional antiterminator
B14_02352	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B14_02356	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B14_02356	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B14_02356	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B14_02357	COG1482	cell wall glycoprotein biosynthetic process
B14_02358	COG1960	acyl-CoA dehydrogenase activity
B14_02359	COG2084	Dehydrogenase
B14_02360	COG1012	belongs to the aldehyde dehydrogenase family
B14_02361	COG1024	Enoyl-CoA hydratase
B14_02366	COG0789	Transcriptional regulator
B14_02367	COG1064	alcohol dehydrogenase
B14_02368	COG1114	Component of the transport system for branched-chain amino acids
B14_02369	COG3420	alginic acid biosynthetic process
B14_02370	COG0477	Major facilitator Superfamily
B14_02375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B14_02377	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B14_02379	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
B14_02381	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B14_02383	COG2223	nitrite transmembrane transporter activity
B14_02384	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B14_02386	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B14_02390	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B14_02391	COG1140	nitrate reductase beta subunit
B14_02392	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B14_02393	COG2181	nitrate reductase activity
B14_02395	COG1115	amino acid carrier protein
B14_02400	COG2160	L-arabinose isomerase activity
B14_02403	COG1609	Transcriptional regulator
B14_02404	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B14_02405	COG0187	DNA topoisomerase II activity
B14_02406	COG1832	CoA-binding protein
B14_02407	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B14_02408	COG4841	protein insertion into membrane
B14_02412	COG0824	Thioesterase
B14_02416	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B14_02417	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B14_02418	COG0071	Belongs to the small heat shock protein (HSP20) family
B14_02420	COG4846	Membrane protein involved in cytochrome C biogenesis
B14_02421	COG2201	protein-glutamate methylesterase activity
B14_02422	COG0785	Cytochrome C biogenesis protein
B14_02424	COG3763	UPF0154 protein
B14_02426	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B14_02427	COG4224	UPF0291 protein
B14_02428	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B14_02429	COG1388	LysM domain
B14_02430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B14_02431	COG3209	COG3209 Rhs family protein
B14_02432	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B14_02435	COG0655	NAD(P)H dehydrogenase (quinone) activity
B14_02436	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B14_02437	COG0346	lactoylglutathione lyase activity
B14_02438	COG0778	Nitroreductase
B14_02439	COG1846	Transcriptional regulator
B14_02444	COG3546	catalase activity
B14_02445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B14_02448	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B14_02449	COG2076	Multidrug Resistance protein
B14_02450	COG2076	Multidrug Resistance protein
B14_02451	COG1309	transcriptional regulator
B14_02460	COG1073	alpha beta
B14_02468	COG0174	glutamine synthetase
B14_02469	COG0789	Transcriptional regulator
B14_02470	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B14_02471	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B14_02472	COG0464	growth
B14_02483	COG1309	transcriptional regulator
B14_02489	COG0697	spore germination
B14_02490	COG1802	Transcriptional regulator
B14_02491	COG0735	belongs to the Fur family
B14_02494	COG4112	unkown
B14_02495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B14_02496	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B14_02497	COG1780	Probably involved in ribonucleotide reductase function
B14_02499	COG1923	regulation of RNA biosynthetic process
B14_02500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B14_02503	COG2076	Multidrug Resistance protein
B14_02504	COG2076	Multidrug Resistance protein
B14_02505	COG1764	response to oxidative stress
B14_02507	COG0702	epimerase
B14_02508	COG3631	Ketosteroid isomerase-related protein
B14_02509	COG1309	transcriptional regulator
B14_02510	COG1388	LysM domain
B14_02510	COG3858	chitin binding
B14_02512	COG5577	PFAM Coat F domain
B14_02513	COG0531	amino acid
B14_02514	COG1819	glycosyl
B14_02515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B14_02516	COG0398	Pfam SNARE associated Golgi protein
B14_02517	COG0393	Putative heavy-metal-binding
B14_02518	COG2267	carboxylic ester hydrolase activity
B14_02519	COG2267	carboxylic ester hydrolase activity
B14_02520	COG2814	Major facilitator Superfamily
B14_02521	COG2814	Major facilitator Superfamily
B14_02522	COG3263	regulation of cellular component size
B14_02523	COG3619	membrane
B14_02524	COG1231	oxidoreductase activity
B14_02525	COG1231	oxidoreductase activity
B14_02528	COG1247	-acetyltransferase
B14_02530	COG0523	cobalamin synthesis protein
B14_02533	COG5444	nuclease activity
B14_02534	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B14_02535	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B14_02536	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B14_02538	COG4550	Control of competence regulator ComK, YlbF/YmcA
B14_02539	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B14_02540	COG0156	8-amino-7-oxononanoate synthase activity
B14_02541	COG1063	alcohol dehydrogenase
B14_02543	COG2359	stage V sporulation protein S
B14_02544	COG1692	metallophosphoesterase
B14_02545	COG1418	mRNA catabolic process
B14_02546	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B14_02547	COG1546	Belongs to the CinA family
B14_02547	COG1058	Belongs to the CinA family
B14_02548	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B14_02549	COG1426	Protein conserved in bacteria
B14_02552	COG0300	oxidoreductase activity
B14_02553	COG0612	Peptidase, M16
B14_02554	COG0612	Peptidase, M16
B14_02555	COG2814	Major facilitator Superfamily
B14_02556	COG2188	Transcriptional regulator
B14_02557	COG1674	ftsk spoiiie
B14_02557	COG4980	gas vesicle protein
B14_02559	COG0740	serine-type endopeptidase activity
B14_02560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B14_02562	COG0527	aspartate kinase activity
B14_02563	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B14_02564	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B14_02565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B14_02566	COG1873	PFAM PRC-barrel domain
B14_02567	COG0612	Peptidase, M16
B14_02568	COG0726	polysaccharide deacetylase
B14_02569	COG1185	polyribonucleotide nucleotidyltransferase activity
B14_02570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B14_02571	COG0196	riboflavin kinase activity
B14_02572	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B14_02573	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B14_02574	COG1550	Protein conserved in bacteria
B14_02575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B14_02576	COG1358	cellular component organization or biogenesis
B14_02577	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B14_02578	COG0195	Participates in both transcription termination and antitermination
B14_02579	COG0779	Required for maturation of 30S ribosomal subunits
B14_02584	COG2176	DNA-directed DNA polymerase activity
B14_02585	COG0442	prolyl-tRNA aminoacylation
B14_02586	COG0750	zinc metalloprotease
B14_02587	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B14_02588	COG4589	Belongs to the CDS family
B14_02589	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B14_02590	COG0233	cytoplasmic translational termination
B14_02591	COG0528	UMP kinase activity
B14_02592	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B14_02593	COG0052	Belongs to the universal ribosomal protein uS2 family
B14_02595	COG1191	sigma factor activity
B14_02596	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B14_02597	COG1776	CheC inhibitor of MCP methylation
B14_02598	COG0835	chemotaxis
B14_02599	COG2198	Histidine kinase
B14_02599	COG0643	Histidine kinase
B14_02600	COG2201	protein-glutamate methylesterase activity
B14_02601	COG0455	bacterial-type flagellum organization
B14_02602	COG1419	protein localization to endoplasmic reticulum
B14_02603	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B14_02604	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B14_02605	COG1684	flagellar biosynthetic protein fliR
B14_02606	COG1987	bacterial-type flagellum assembly
B14_02607	COG1338	Plays a role in the flagellum-specific transport system
B14_02608	COG3190	flagellar
B14_02609	COG2201	protein-glutamate methylesterase activity
B14_02610	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B14_02610	COG1776	CheC inhibitor of MCP methylation
B14_02611	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B14_02612	COG1580	Controls the rotational direction of flagella during chemotaxis
B14_02613	COG4786	Flagellar basal body rod
B14_02614	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B14_02615	COG3144	bacterial-type flagellum assembly
B14_02617	COG2882	bacterial-type flagellum organization
B14_02618	COG1157	protein secretion by the type III secretion system
B14_02619	COG1317	bacterial-type flagellum organization
B14_02620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B14_02621	COG1766	The M ring may be actively involved in energy transduction
B14_02622	COG1677	Flagellar hook-basal body complex protein FliE
B14_02623	COG1558	bacterial-type flagellum-dependent cell motility
B14_02624	COG1815	bacterial-type flagellum-dependent cell motility
B14_02626	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B14_02627	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B14_02628	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B14_02629	COG4974	Belongs to the 'phage' integrase family
B14_02630	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B14_02631	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B14_02632	COG0758	DNA mediated transformation
B14_02633	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B14_02634	COG0045	succinate-CoA ligase (ADP-forming) activity
B14_02635	COG2257	FlhB HrpN YscU SpaS Family
B14_02637	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B14_02638	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B14_02639	COG0335	large ribosomal subunit rRNA binding
B14_02640	COG0336	Belongs to the RNA methyltransferase TrmD family
B14_02641	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B14_02643	COG1837	Belongs to the UPF0109 family
B14_02644	COG0228	four-way junction DNA binding
B14_02645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B14_02646	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B14_02647	COG0552	protein localization to endoplasmic reticulum
B14_02648	COG1196	nuclear chromosome segregation
B14_02649	COG0571	ribonuclease III activity
B14_02650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B14_02651	COG1028	Short-chain dehydrogenase reductase Sdr
B14_02652	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B14_02653	COG0416	fatty acid biosynthetic process
B14_02654	COG1349	DNA-binding transcription factor activity
B14_02655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B14_02656	COG1760	l-serine dehydratase
B14_02657	COG1760	l-serine dehydratase
B14_02658	COG1461	Dihydroxyacetone kinase
B14_02659	COG1302	Protein conserved in bacteria
B14_02660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B14_02661	COG1564	THIamine pyrophosphokinase
B14_02662	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B14_02663	COG1162	GTPase activity
B14_02664	COG0515	serine threonine protein kinase
B14_02664	COG2815	serine threonine protein kinase
B14_02665	COG0631	protein serine/threonine phosphatase activity
B14_02666	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B14_02667	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B14_02667	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B14_02668	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B14_02669	COG0242	peptide deformylase activity
B14_02670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B14_02671	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B14_02672	COG1758	RNA polymerase activity
B14_02673	COG0194	GDP metabolic process
B14_02674	COG2052	Domain of unknown function (DUF370)
B14_02675	COG1561	YicC-like family, N-terminal region
B14_02676	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B14_02678	COG1648	precorrin-2 dehydrogenase activity
B14_02679	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B14_02680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B14_02681	COG0529	Catalyzes the synthesis of activated sulfate
B14_02682	COG2046	Belongs to the sulfate adenylyltransferase family
B14_02683	COG0306	phosphate transporter
B14_02684	COG0175	sulfate reduction
B14_02686	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B14_02687	COG0284	orotidine-5'-phosphate decarboxylase activity
B14_02688	COG0167	dihydroorotate dehydrogenase activity
B14_02689	COG0543	2 iron, 2 sulfur cluster binding
B14_02690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B14_02691	COG0505	Belongs to the CarA family
B14_02692	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B14_02693	COG0540	Belongs to the ATCase OTCase family
B14_02694	COG2233	PERMEase
B14_02695	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B14_02696	COG0564	pseudouridine synthase activity
B14_02697	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B14_02698	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B14_02699	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B14_02700	COG3599	regulation of cell shape
B14_02701	COG2302	S4 RNA-binding domain
B14_02702	COG0762	integral membrane protein
B14_02703	COG1799	cell septum assembly
B14_02704	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B14_02706	COG1873	PFAM PRC-barrel domain
B14_02707	COG0500	methyltransferase
B14_02708	COG1119	ATPase activity
B14_02709	COG1191	sigma factor activity
B14_02710	COG1191	sigma factor activity
B14_02712	COG4412	M6 family metalloprotease domain protein
B14_02712	COG1404	Belongs to the peptidase S8 family
B14_02713	COG4412	M6 family metalloprotease domain protein
B14_02713	COG1404	Belongs to the peptidase S8 family
B14_02714	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B14_02715	COG0849	cell division
B14_02716	COG3856	small basic protein
B14_02717	COG3879	Bacterial protein of unknown function (DUF881)
B14_02718	COG3879	Bacterial protein of unknown function (DUF881)
B14_02719	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B14_02720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B14_02721	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B14_02722	COG0772	Belongs to the SEDS family
B14_02723	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B14_02724	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B14_02725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B14_02727	COG0768	penicillin binding
B14_02729	COG4839	cell division protein FtsL
B14_02730	COG0275	rRNA processing
B14_02731	COG2001	Belongs to the MraZ family
B14_02732	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B14_02733	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B14_02734	COG0454	-acetyltransferase
B14_02736	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B14_02737	COG1399	metal-binding, possibly nucleic acid-binding protein
B14_02738	COG1323	Belongs to the UPF0348 family
B14_02739	COG3480	Lon protease (S16) C-terminal proteolytic domain
B14_02740	COG3314	Sporulation integral membrane protein YlbJ
B14_02741	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B14_02742	COG0742	ribosomal rna small subunit methyltransferase
B14_02744	COG4471	UPF0298 protein
B14_02745	COG3679	Belongs to the UPF0342 family
B14_02748	COG2340	Cysteine-rich secretory protein family
B14_02749	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B14_02751	COG3336	cytochrome c oxidase
B14_02752	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B14_02753	COG1845	cytochrome c oxidase, subunit III
B14_02754	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B14_02755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B14_02755	COG2010	Cytochrome c
B14_02756	COG0109	protoheme IX farnesyltransferase activity
B14_02757	COG1612	heme a metabolic process
B14_02758	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B14_02759	COG0772	Belongs to the SEDS family
B14_02760	COG4838	Belongs to the UPF0358 family
B14_02761	COG2066	Belongs to the glutaminase family
B14_02762	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B14_02763	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B14_02765	COG4896	Protein conserved in bacteria
B14_02766	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B14_02767	COG1846	Transcriptional regulator
B14_02772	COG1595	DNA-templated transcription, initiation
B14_02776	COG0483	inositol monophosphate 1-phosphatase activity
B14_02778	COG4493	Belongs to the UPF0637 family
B14_02779	COG4476	Belongs to the UPF0223 family
B14_02780	COG1982	Orn Lys Arg decarboxylase major
B14_02782	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B14_02784	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B14_02785	COG0508	dehydrogenase complex catalyzes the overall conversion of
B14_02786	COG0022	dehydrogenase e1 component
B14_02787	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B14_02788	COG0497	DNA recombination
B14_02790	COG0242	peptide deformylase activity
B14_02792	COG0561	phosphatase activity
B14_02794	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B14_02795	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B14_02796	COG0569	domain protein
B14_02797	COG3852	Histidine kinase
B14_02798	COG2002	toxin-antitoxin pair type II binding
B14_02799	COG1077	Cell shape determining protein MreB Mrl
B14_02801	COG2309	aminopeptidase activity
B14_02803	COG0488	(ABC) transporter
B14_02807	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B14_02807	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B14_02807	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B14_02808	COG1105	Belongs to the carbohydrate kinase PfkB family
B14_02809	COG1349	DNA-binding transcription factor activity
B14_02810	COG0577	efflux transmembrane transporter activity
B14_02811	COG1136	(ABC) transporter
B14_02812	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B14_02814	COG1132	(ABC) transporter
B14_02815	COG1132	(ABC) transporter
B14_02817	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B14_02818	COG0314	molybdopterin synthase activity
B14_02819	COG1763	Mo-molybdopterin cofactor biosynthetic process
B14_02820	COG0303	'Molybdopterin
B14_02821	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B14_02822	COG0746	molybdenum cofactor guanylyltransferase activity
B14_02825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B14_02826	COG0450	alkyl hydroperoxide reductase
B14_02828	COG1473	amidohydrolase
B14_02829	COG2171	N-acyltransferase activity
B14_02830	COG0716	FMN binding
B14_02832	COG0716	FMN binding
B14_02833	COG0583	DNA-binding transcription factor activity
B14_02834	COG0517	IMP dehydrogenase activity
B14_02836	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B14_02838	COG4703	Protein of unknown function (DUF1797)
B14_02840	COG2200	EAL domain
B14_02841	COG1028	Short-chain dehydrogenase reductase Sdr
B14_02842	COG1408	metallophosphoesterase
B14_02843	COG1376	ErfK ybiS ycfS ynhG family protein
B14_02844	COG2814	Major facilitator Superfamily
B14_02846	COG0835	chemotaxis
B14_02846	COG0784	Response regulator, receiver
B14_02848	COG1714	RDD family
B14_02850	COG0436	Aminotransferase
B14_02851	COG4191	Histidine kinase
B14_02852	COG0768	penicillin binding
B14_02853	COG2340	Cysteine-rich secretory protein family
B14_02854	COG2084	Dehydrogenase
B14_02855	COG1028	Short-chain dehydrogenase reductase Sdr
B14_02856	COG0840	transmembrane signaling receptor activity
B14_02857	COG0456	acetyltransferase
B14_02858	COG1533	DNA photolyase activity
B14_02860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B14_02861	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B14_02862	COG1263	PTS System
B14_02862	COG2190	(PTS) system
B14_02862	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_02863	COG3711	transcriptional antiterminator
B14_02864	COG1609	Transcriptional regulator
B14_02867	COG0006	proline dipeptidase activity
B14_02868	COG2217	Heavy metal translocating P-type atpase
B14_02869	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B14_02870	COG2244	polysaccharide biosynthetic process
B14_02871	COG3773	Cell wall hydrolase
B14_02873	COG4873	Protein conserved in bacteria
B14_02879	COG3655	Transcriptional regulator
B14_02880	COG3739	integral membrane protein
B14_02881	COG0457	Tetratricopeptide repeat
B14_02882	COG0457	Tetratricopeptide repeat
B14_02885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B14_02886	COG0602	queuosine metabolic process
B14_02887	COG0720	synthase
B14_02888	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B14_02889	COG3949	Membrane
B14_02890	COG0542	response to heat
B14_02891	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B14_02892	COG1360	Flagellar Motor Protein
B14_02893	COG1846	Transcriptional regulator
B14_02894	COG3852	Histidine kinase
B14_02896	COG3339	Conserved Protein
B14_02897	COG0346	lactoylglutathione lyase activity
B14_02898	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B14_02899	COG0235	Class ii aldolase
B14_02899	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
B14_02900	COG1850	ribulose-bisphosphate carboxylase activity
B14_02901	COG0436	Aminotransferase
B14_02902	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B14_02903	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B14_02904	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B14_02906	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B14_02907	COG5002	protein histidine kinase activity
B14_02908	COG3594	Acyltransferase
B14_02911	COG0768	penicillin binding
B14_02912	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B14_02913	COG0501	Belongs to the peptidase M48B family
B14_02917	COG1191	sigma factor activity
B14_02918	COG0861	Integral membrane protein TerC family
B14_02919	COG0586	Pfam SNARE associated Golgi protein
B14_02920	COG5001	Diguanylate cyclase
B14_02920	COG3300	MHYT domain
B14_02921	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B14_02922	COG3285	dna ligase
B14_02922	COG1793	dna ligase
B14_02923	COG1846	Transcriptional regulator
B14_02926	COG0789	Transcriptional regulator
B14_02928	COG2239	Acts as a magnesium transporter
B14_02930	COG1404	Belongs to the peptidase S8 family
B14_02931	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B14_02934	COG0406	alpha-ribazole phosphatase activity
B14_02935	COG0590	tRNA wobble adenosine to inosine editing
B14_02937	COG1764	response to oxidative stress
B14_02938	COG1846	Transcriptional regulator
B14_02939	COG1764	response to oxidative stress
B14_02940	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B14_02941	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B14_02942	COG0788	formyltetrahydrofolate deformylase activity
B14_02943	COG2076	Multidrug Resistance protein
B14_02944	COG2076	Multidrug Resistance protein
B14_02945	COG2318	DinB family
B14_02949	COG3866	Pectate lyase
B14_02950	COG2323	membrane
B14_02951	COG1607	acyl-coa hydrolase
B14_02952	COG1834	amidinotransferase
B14_02953	COG4608	Belongs to the ABC transporter superfamily
B14_02954	COG0791	NLP P60 protein
B14_02955	COG4948	Mandelate Racemase Muconate Lactonizing
B14_02956	COG1619	proteins homologs of microcin C7 resistance protein MccF
B14_02957	COG4166	transmembrane transport
B14_02958	COG0444	Belongs to the ABC transporter superfamily
B14_02959	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B14_02960	COG0601	transmembrane transport
B14_02961	COG2362	D-Aminopeptidase
B14_02962	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B14_02963	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B14_02965	COG0346	lactoylglutathione lyase activity
B14_02966	COG0531	amino acid
B14_02967	COG0395	ABC-type sugar transport system, permease component
B14_02968	COG4209	transmembrane transport
B14_02969	COG1653	transport
B14_02971	COG1874	Beta-galactosidase
B14_02972	COG2755	lipolytic protein G-D-S-L family
B14_02973	COG0667	Aldo Keto reductase
B14_02974	COG3401	FG-GAP repeat protein
B14_02975	COG2755	lipolytic protein G-D-S-L family
B14_02977	COG3401	FG-GAP repeat protein
B14_02978	COG3401	FG-GAP repeat protein
B14_02979	COG5578	integral membrane protein
B14_02981	COG2755	lipolytic protein G-D-S-L family
B14_02982	COG2207	Transcriptional regulator
B14_02983	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B14_02984	COG0395	ABC-type sugar transport system, permease component
B14_02985	COG1175	transmembrane transport
B14_02986	COG1653	transport
B14_02987	COG4753	response regulator
B14_02987	COG2207	Transcriptional regulator
B14_02988	COG2972	Histidine kinase
B14_02989	COG5578	integral membrane protein
B14_02990	COG0405	Gamma-glutamyltransferase
B14_02991	COG1392	Phosphate transport regulator
B14_02992	COG0306	phosphate transporter
B14_02995	COG2271	Major facilitator Superfamily
B14_02996	COG1063	alcohol dehydrogenase
B14_02997	COG1028	Short-chain dehydrogenase reductase Sdr
B14_02998	COG1312	Catalyzes the dehydration of D-mannonate
B14_02999	COG1063	alcohol dehydrogenase
B14_03000	COG1802	Transcriptional regulator
B14_03007	COG3778	Protein conserved in bacteria
B14_03008	COG3299	homolog of phage Mu protein gp47
B14_03009	COG3628	GPW Gp25 family protein
B14_03011	COG4193	domain, Protein
B14_03012	COG1652	LysM domain
B14_03013	COG5412	phage tail tape measure protein
B14_03013	COG3953	SLT domain
B14_03022	COG4653	Phage capsid family
B14_03023	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B14_03024	COG5518	Phage portal protein
B14_03025	COG1783	phage Terminase large subunit
B14_03026	COG3728	DNA packaging
B14_03026	COG5484	DNA packaging
B14_03027	COG1595	DNA-templated transcription, initiation
B14_03031	COG1484	DNA-dependent DNA replication
B14_03032	COG1522	sequence-specific DNA binding
B14_03035	COG1396	sequence-specific DNA binding
B14_03036	COG2856	Zn peptidase
B14_03037	COG4195	phage-related replication protein
B14_03038	COG5444	nuclease activity
B14_03041	COG1309	transcriptional regulator
B14_03042	COG2814	Major facilitator Superfamily
B14_03043	COG3584	3D domain protein
B14_03043	COG1388	LysM domain
B14_03045	COG0346	lactoylglutathione lyase activity
B14_03046	COG0697	spore germination
B14_03047	COG0583	DNA-binding transcription factor activity
B14_03048	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B14_03049	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B14_03050	COG0583	DNA-binding transcription factor activity
B14_03052	COG0110	maltose O-acetyltransferase activity
B14_03055	COG3507	Belongs to the glycosyl hydrolase 43 family
B14_03056	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B14_03059	COG5505	Protein of unknown function (DUF819)
B14_03060	COG0626	cystathionine gamma-synthase activity
B14_03061	COG0626	cystathionine gamma-synthase activity
B14_03064	COG2382	esterase
B14_03065	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B14_03066	COG2153	protein acetylation
B14_03067	COG2246	polysaccharide biosynthetic process
B14_03068	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B14_03069	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B14_03070	COG0586	Pfam SNARE associated Golgi protein
B14_03072	COG0210	DNA helicase
B14_03083	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B14_03084	COG0351	phosphomethylpyrimidine kinase
B14_03085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B14_03086	COG2022	thiamine diphosphate biosynthetic process
B14_03087	COG2104	thiamine diphosphate biosynthetic process
B14_03089	COG0352	thiamine-phosphate diphosphorylase activity
B14_03090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B14_03091	COG0569	domain protein
B14_03091	COG0475	glutathione-regulated potassium exporter activity
B14_03092	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B14_03093	COG0564	pseudouridine synthase activity
B14_03094	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B14_03095	COG2357	RelA SpoT domain protein
B14_03097	COG4116	CYTH
B14_03098	COG0741	lytic transglycosylase activity
B14_03099	COG2346	COG2346, Truncated hemoglobins
B14_03102	COG1164	Oligoendopeptidase f
B14_03103	COG4469	Competence protein
B14_03104	COG3290	protein histidine kinase activity
B14_03105	COG4565	transcriptional regulatory protein
B14_03109	COG4862	establishment of competence for transformation
B14_03110	COG0861	Integral membrane protein TerC family
B14_03111	COG1393	Belongs to the ArsC family
B14_03112	COG0456	acetyltransferase
B14_03113	COG4608	Belongs to the ABC transporter superfamily
B14_03114	COG0444	Belongs to the ABC transporter superfamily
B14_03115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B14_03116	COG0601	transmembrane transport
B14_03117	COG4166	transmembrane transport
B14_03118	COG0180	Tryptophanyl-tRNA synthetase
B14_03123	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B14_03124	COG0601	transmembrane transport
B14_03126	COG4608	Belongs to the ABC transporter superfamily
B14_03127	COG0444	Belongs to the ABC transporter superfamily
B14_03128	COG5504	Zn-dependent protease
B14_03129	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B14_03130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B14_03133	COG1744	ABC transporter substrate-binding protein PnrA-like
B14_03135	COG2267	carboxylic ester hydrolase activity
B14_03138	COG1968	undecaprenyl-diphosphatase activity
B14_03139	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B14_03140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B14_03141	COG0505	Belongs to the CarA family
B14_03142	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B14_03143	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B14_03144	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B14_03145	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B14_03146	COG2151	metal-sulfur cluster biosynthetic enzyme
B14_03147	COG1073	alpha beta
B14_03148	COG0561	phosphatase activity
B14_03150	COG0516	GMP reductase activity
B14_03152	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B14_03153	COG1307	EDD domain protein, DegV family
B14_03156	COG2996	Protein conserved in bacteria
B14_03157	COG1666	GTP binding
B14_03158	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B14_03158	COG0646	methionine synthase
B14_03159	COG0646	methionine synthase
B14_03159	COG1410	methionine synthase
B14_03160	COG2378	regulation of single-species biofilm formation
B14_03161	COG1028	Short-chain dehydrogenase reductase Sdr
B14_03162	COG2153	protein acetylation
B14_03167	COG0076	glutamate decarboxylase activity
B14_03169	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B14_03170	COG1279	arginine transmembrane transporter activity
B14_03175	COG0673	inositol 2-dehydrogenase activity
B14_03176	COG1609	Transcriptional regulator
B14_03178	COG1917	Cupin 2, conserved barrel domain protein
B14_03178	COG2207	Transcriptional regulator
B14_03179	COG0534	Mate efflux family protein
B14_03180	COG0347	Belongs to the P(II) protein family
B14_03181	COG0004	ammonium transporteR
B14_03182	COG0367	asparagine synthase
B14_03187	COG0179	Fumarylacetoacetate (FAA) hydrolase
B14_03189	COG5337	Spore coat protein CotH
B14_03198	COG0419	ATPase involved in DNA repair
B14_03199	COG0420	3'-5' exonuclease activity
B14_03200	COG1074	ATP-dependent DNA helicase activity
B14_03201	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B14_03202	COG4149	molybdate abc transporter
B14_03203	COG0725	ABC transporter, periplasmic molybdate-binding protein
B14_03204	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
B14_03205	COG0745	RESPONSE REGULATOR receiver
B14_03206	COG5002	protein histidine kinase activity
B14_03208	COG2814	Major facilitator Superfamily
B14_03208	COG0477	Major facilitator Superfamily
B14_03209	COG0318	PFAM AMP-dependent synthetase and ligase
B14_03210	COG3546	catalase activity
B14_03213	COG3180	Ammonia monooxygenase
B14_03214	COG1486	melibiose metabolic process
B14_03222	COG0457	Tetratricopeptide repeat
B14_03223	COG2814	Major facilitator Superfamily
B14_03224	COG0549	Belongs to the carbamate kinase family
B14_03226	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B14_03227	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B14_03228	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B14_03229	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B14_03230	COG3257	ureidoglycine aminohydrolase activity
B14_03231	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B14_03232	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B14_03233	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B14_03235	COG2508	Transcriptional regulator
B14_03237	COG1404	Belongs to the peptidase S8 family
B14_03238	COG0681	Belongs to the peptidase S26 family
B14_03239	COG0398	Pfam SNARE associated Golgi protein
B14_03241	COG4903	ComK protein
B14_03243	COG1028	Short-chain dehydrogenase reductase Sdr
B14_03244	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B14_03244	COG0723	plastoquinol--plastocyanin reductase activity
B14_03245	COG0840	transmembrane signaling receptor activity
B14_03246	COG0406	alpha-ribazole phosphatase activity
B14_03247	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B14_03248	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B14_03249	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B14_03250	COG0697	spore germination
B14_03252	COG0501	Belongs to the peptidase M48B family
B14_03255	COG1396	sequence-specific DNA binding
B14_03257	COG0318	PFAM AMP-dependent synthetase and ligase
B14_03258	COG0095	Lipoate-protein ligase
B14_03259	COG1234	tRNA 3'-trailer cleavage
B14_03261	COG1301	dicarboxylic acid transport
B14_03263	COG1363	Peptidase, m42
B14_03264	COG1363	Peptidase, m42
B14_03265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B14_03266	COG1511	domain protein
B14_03267	COG1309	transcriptional regulator
B14_03270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B14_03271	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B14_03272	COG2329	Antibiotic biosynthesis monooxygenase
B14_03273	COG3069	C4-dicarboxylate transmembrane transporter activity
B14_03274	COG1473	amidohydrolase
B14_03276	COG4473	ABC transporter
B14_03277	COG1131	(ABC) transporter
B14_03278	COG0537	adenosine 5'-monophosphoramidase activity
B14_03279	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B14_03282	COG4980	gas vesicle protein
B14_03283	COG1846	Transcriptional regulator
B14_03287	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B14_03289	COG3481	metal-dependent phosphohydrolase, HD sub domain
B14_03290	COG4717	serine-type aminopeptidase activity
B14_03291	COG0420	3'-5' exonuclease activity
B14_03292	COG1668	transmembrane transport
B14_03293	COG4152	abc transporter atp-binding protein
B14_03297	COG0457	Tetratricopeptide repeat
B14_03298	COG1024	Enoyl-CoA hydratase
B14_03300	COG0490	domain, Protein
B14_03301	COG0475	glutathione-regulated potassium exporter activity
B14_03302	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B14_03303	COG0561	phosphatase activity
B14_03304	COG3679	Belongs to the UPF0342 family
B14_03305	COG4399	Belongs to the UPF0754 family
B14_03306	COG0189	ligase activity
B14_03307	COG0189	ligase activity
B14_03309	COG2508	Transcriptional regulator
B14_03310	COG3842	ATPase activity
B14_03314	COG0702	epimerase
B14_03315	COG1132	(ABC) transporter
B14_03316	COG1132	(ABC) transporter
B14_03318	COG0589	response to stress
B14_03322	COG2017	converts alpha-aldose to the beta-anomer
B14_03323	COG1757	Na H antiporter
B14_03325	COG0726	polysaccharide deacetylase
B14_03327	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B14_03328	COG0668	transmembrane transport
B14_03330	COG0584	glycerophosphoryl diester phosphodiesterase
B14_03331	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B14_03332	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B14_03336	COG1253	flavin adenine dinucleotide binding
B14_03338	COG0789	Transcriptional regulator
B14_03339	COG1253	flavin adenine dinucleotide binding
B14_03340	COG1309	transcriptional regulator
B14_03342	COG3152	Membrane
B14_03344	COG0204	Acyl-transferase
B14_03346	COG0662	Cupin 2, conserved barrel domain protein
B14_03347	COG1595	DNA-templated transcription, initiation
B14_03351	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B14_03352	COG3708	Transcriptional regulator
B14_03352	COG2207	Transcriptional regulator
B14_03354	COG0733	neurotransmitter:sodium symporter activity
B14_03355	COG1028	Short-chain dehydrogenase reductase Sdr
B14_03356	COG2133	pyrroloquinoline quinone binding
B14_03357	COG0372	Belongs to the citrate synthase family
B14_03358	COG0583	DNA-binding transcription factor activity
B14_03359	COG0791	NLP P60 protein
B14_03359	COG1388	LysM domain
B14_03360	COG2719	SpoVR family
B14_03361	COG1017	nitric oxide dioxygenase activity
B14_03361	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B14_03362	COG1959	2 iron, 2 sulfur cluster binding
B14_03365	COG0431	NADPH-dependent FMN reductase
B14_03366	COG2197	response regulator
B14_03367	COG2203	Gaf domain
B14_03367	COG4585	Histidine kinase
B14_03370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B14_03371	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B14_03372	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B14_03373	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B14_03374	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B14_03375	COG0604	alcohol dehydrogenase
B14_03376	COG0679	Auxin Efflux Carrier
B14_03377	COG2116	formate transmembrane transporter activity
B14_03378	COG0488	(ABC) transporter
B14_03380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B14_03380	COG3153	acetyltransferase
B14_03381	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B14_03382	COG0517	IMP dehydrogenase activity
B14_03384	COG0564	pseudouridine synthase activity
B14_03385	COG3764	Sortase (surface protein transpeptidase)
B14_03386	COG1525	nuclease
B14_03386	COG4085	toxin activity
B14_03386	COG0737	Belongs to the 5'-nucleotidase family
B14_03387	COG5002	protein histidine kinase activity
B14_03388	COG5577	PFAM Coat F domain
B14_03393	COG1823	symporter activity
B14_03394	COG1464	Belongs to the NlpA lipoprotein family
B14_03395	COG2011	ABC-type metal ion transport system permease component
B14_03396	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B14_03397	COG1278	Cold shock
B14_03398	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B14_03399	COG1131	(ABC) transporter
B14_03401	COG0655	NAD(P)H dehydrogenase (quinone) activity
B14_03402	COG2814	Major facilitator Superfamily
B14_03403	COG1566	PFAM secretion protein HlyD family protein
B14_03404	COG2718	Belongs to the UPF0229 family
B14_03405	COG2766	serine protein kinase
B14_03407	COG1664	Polymer-forming cytoskeletal
B14_03408	COG0789	Transcriptional regulator
B14_03409	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B14_03411	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B14_03412	COG3382	B3 4 domain protein
B14_03414	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B14_03418	COG1131	(ABC) transporter
B14_03420	COG1476	TRANSCRIPTIONal
B14_03422	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B14_03423	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B14_03424	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B14_03425	COG1116	anion transmembrane transporter activity
B14_03426	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B14_03427	COG0710	3-dehydroquinate dehydratase activity
B14_03428	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B14_03429	COG0457	Tetratricopeptide repeat
B14_03430	COG5444	nuclease activity
B14_03435	COG0457	Tetratricopeptide repeat
B14_03457	COG0735	belongs to the Fur family
B14_03458	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B14_03459	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B14_03460	COG4129	membrane
B14_03463	COG0747	negative chemotaxis
B14_03464	COG4608	Belongs to the ABC transporter superfamily
B14_03465	COG0444	Belongs to the ABC transporter superfamily
B14_03466	COG1132	(ABC) transporter
B14_03467	COG3557	Belongs to the UPF0374 family
B14_03470	COG1028	Short-chain dehydrogenase reductase Sdr
B14_03472	COG1194	a g-specific adenine glycosylase
B14_03473	COG1988	membrane-bound metal-dependent
B14_03474	COG4485	Bacterial membrane protein, YfhO
B14_03476	COG0463	Glycosyl transferase, family 2
B14_03481	COG2137	regulation of response to DNA damage stimulus
B14_03482	COG1090	epimerase
B14_03486	COG0778	Nitroreductase
B14_03487	COG0384	phenazine biosynthesis protein PhzF
B14_03489	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B14_03489	COG0392	lysyltransferase activity
B14_03491	COG1051	belongs to the nudix hydrolase family
B14_03492	COG2249	NAD(P)H dehydrogenase (quinone) activity
B14_03493	COG1653	transport
B14_03494	COG1917	Cupin 2, conserved barrel domain protein
B14_03494	COG2207	Transcriptional regulator
B14_03495	COG3507	Belongs to the glycosyl hydrolase 43 family
B14_03497	COG2514	catechol 2,3-dioxygenase activity
B14_03498	COG2259	Doxx family
B14_03499	COG1733	regulation of RNA biosynthetic process
B14_03502	COG1263	PTS System
B14_03502	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_03503	COG1737	Transcriptional regulator
B14_03504	COG1486	melibiose metabolic process
B14_03505	COG1742	UPF0060 membrane protein
B14_03506	COG3284	Transcriptional regulator
B14_03507	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B14_03508	COG0508	dehydrogenase complex catalyzes the overall conversion of
B14_03509	COG0022	dehydrogenase e1 component
B14_03510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B14_03512	COG5609	conserved protein (DUF2294)
B14_03513	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B14_03514	COG3002	Belongs to the UPF0753 family
B14_03515	COG0288	reversible hydration of carbon dioxide
B14_03516	COG3711	transcriptional antiterminator
B14_03517	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_03517	COG1263	PTS System
B14_03518	COG0477	Major facilitator Superfamily
B14_03520	COG1819	glycosyl
B14_03524	COG4637	Psort location Cytoplasmic, score
B14_03525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B14_03526	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B14_03527	COG0598	Magnesium transport protein CorA
B14_03529	COG0371	Dehydrogenase
B14_03530	COG0726	polysaccharide deacetylase
B14_03532	COG0535	radical SAM domain protein
B14_03534	COG0387	Pfam Sodium calcium exchanger
B14_03536	COG0477	Major facilitator Superfamily
B14_03538	COG1295	ribonuclease BN
B14_03539	COG4980	gas vesicle protein
B14_03540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B14_03541	COG1115	amino acid carrier protein
B14_03542	COG4840	Belongs to the UPF0435 family
B14_03543	COG0693	protein deglycase activity
B14_03544	COG0737	Belongs to the 5'-nucleotidase family
B14_03545	COG0778	Nitroreductase
B14_03546	COG1733	regulation of RNA biosynthetic process
B14_03549	COG0673	inositol 2-dehydrogenase activity
B14_03551	COG0457	Tetratricopeptide repeat
B14_03551	COG0463	Glycosyl transferase, family 2
B14_03552	COG1215	transferase activity, transferring glycosyl groups
B14_03554	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B14_03555	COG1045	serine acetyltransferase
B14_03556	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B14_03561	COG2188	Transcriptional regulator
B14_03562	COG0366	Alpha amylase catalytic
B14_03563	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_03563	COG1263	PTS System
B14_03564	COG1115	amino acid carrier protein
B14_03566	COG1368	sulfuric ester hydrolase activity
B14_03567	COG0024	Methionine aminopeptidase
B14_03570	COG2258	MOSC domain
B14_03571	COG1254	Belongs to the acylphosphatase family
B14_03572	COG0640	Transcriptional regulator
B14_03573	COG5658	integral membrane protein
B14_03574	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B14_03576	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B14_03580	COG0471	metal ion transport
B14_03583	COG2130	NADP-dependent
B14_03584	COG0513	Belongs to the DEAD box helicase family
B14_03585	COG0488	(ABC) transporter
B14_03586	COG2814	Major facilitator Superfamily
B14_03587	COG0789	Transcriptional regulator
B14_03589	COG2124	cytochrome p450
B14_03590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B14_03591	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B14_03592	COG0156	8-amino-7-oxononanoate synthase activity
B14_03593	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B14_03594	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B14_03595	COG0523	cobalamin synthesis protein
B14_03598	COG1469	GTP cyclohydrolase I activity
B14_03599	COG0488	(ABC) transporter
B14_03600	COG0471	metal ion transport
B14_03601	COG0840	transmembrane signaling receptor activity
B14_03602	COG1012	belongs to the aldehyde dehydrogenase family
B14_03605	COG0217	transcriptional regulatory protein
B14_03608	COG0457	Tetratricopeptide repeat
B14_03609	COG3711	transcriptional antiterminator
B14_03610	COG2723	6-phospho-beta-galactosidase activity
B14_03611	COG1263	PTS System
B14_03611	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_03611	COG2190	(PTS) system
B14_03615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B14_03616	COG1597	lipid kinase activity
B14_03617	COG1957	nucleoside hydrolase
B14_03618	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B14_03620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B14_03621	COG1309	transcriptional regulator
B14_03622	COG4124	Belongs to the glycosyl hydrolase 26 family
B14_03625	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B14_03626	COG0154	amidase activity
B14_03627	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B14_03629	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B14_03630	COG1285	pathogenesis
B14_03631	COG0363	glucosamine-6-phosphate deaminase activity
B14_03632	COG3457	Alanine racemase
B14_03633	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B14_03634	COG0626	cystathionine gamma-synthase activity
B14_03635	COG1735	metal-dependent hydrolase with the TIM-barrel fold
B14_03636	COG1735	metal-dependent hydrolase with the TIM-barrel fold
B14_03640	COG2188	Transcriptional regulator
B14_03641	COG4851	CamS sex pheromone cAM373 precursor
B14_03642	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B14_03643	COG0210	DNA helicase
B14_03644	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B14_03645	COG4496	protein, YerC YecD
B14_03646	COG1470	cell adhesion involved in biofilm formation
B14_03647	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B14_03652	COG2124	cytochrome p450
B14_03654	COG0151	Belongs to the GarS family
B14_03655	COG0138	bifunctional purine biosynthesis protein purh
B14_03656	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B14_03657	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B14_03658	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B14_03659	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B14_03660	COG0047	phosphoribosylformylglycinamidine synthase activity
B14_03661	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B14_03662	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B14_03663	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B14_03664	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B14_03665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B14_03667	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B14_03670	COG2252	PERMEase
B14_03671	COG0519	Catalyzes the synthesis of GMP from XMP
B14_03671	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B14_03672	COG1305	Transglutaminase-like
B14_03673	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B14_03674	COG0714	Associated with various cellular activities
B14_03675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B14_03678	COG2132	Multicopper oxidase
B14_03680	COG0702	epimerase
B14_03686	COG0823	Involved in the tonB-independent uptake of proteins
B14_03687	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B14_03690	COG1846	Transcriptional regulator
B14_03691	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B14_03692	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B14_03693	COG0366	Alpha amylase catalytic
B14_03694	COG1554	hydrolase, family 65, central catalytic
B14_03695	COG5521	maltodextrose utilization protein MalA
B14_03696	COG3833	ABC-type maltose transport systems, permease component
B14_03697	COG1175	transmembrane transport
B14_03698	COG2182	Extracellular solute-binding protein
B14_03699	COG0366	Alpha amylase catalytic
B14_03700	COG1609	Transcriptional regulator
B14_03702	COG0726	polysaccharide deacetylase
B14_03706	COG0772	Belongs to the SEDS family
B14_03707	COG0772	Belongs to the SEDS family
B14_03708	COG3339	Conserved Protein
B14_03709	COG1280	lysine exporter protein (LysE YggA)
B14_03710	COG1378	Sugar-specific transcriptional regulator TrmB
B14_03712	COG4260	virion core protein, lumpy skin disease virus
B14_03713	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B14_03714	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B14_03715	COG1842	Phage shock protein A
B14_03716	COG2814	Major facilitator Superfamily
B14_03717	COG2272	Belongs to the type-B carboxylesterase lipase family
B14_03718	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
B14_03719	COG3189	MarR family transcriptional regulator
B14_03721	COG0574	Belongs to the PEP-utilizing enzyme family
B14_03721	COG3848	Pyruvate phosphate dikinase
B14_03722	COG1309	transcriptional regulator
B14_03723	COG2135	peptidase activity
B14_03726	COG2720	vancomycin resistance protein
B14_03732	COG0459	protein refolding
B14_03733	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B14_03734	COG1266	CAAX protease self-immunity
B14_03736	COG0805	protein transport
B14_03737	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B14_03738	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B14_03739	COG0315	cyclic pyranopterin monophosphate synthase activity
B14_03740	COG0488	(ABC) transporter
B14_03741	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B14_03742	COG0456	acetyltransferase
B14_03743	COG1214	PFAM Peptidase M22, glycoprotease
B14_03744	COG0802	atpase or kinase
B14_03745	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B14_03753	COG2814	Major facilitator Superfamily
B14_03754	COG3764	Sortase (surface protein transpeptidase)
B14_03756	COG3279	Response regulator of the LytR AlgR family
B14_03757	COG0745	RESPONSE REGULATOR receiver
B14_03757	COG2972	Histidine kinase
B14_03758	COG2814	Major facilitator Superfamily
B14_03759	COG2755	lipolytic protein G-D-S-L family
B14_03759	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B14_03761	COG1595	DNA-templated transcription, initiation
B14_03764	COG1113	amino acid transport
B14_03765	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B14_03768	COG0583	DNA-binding transcription factor activity
B14_03770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B14_03771	COG1733	regulation of RNA biosynthetic process
B14_03773	COG2808	Putative FMN-binding domain
B14_03774	COG0456	acetyltransferase
B14_03775	COG1846	Transcriptional regulator
B14_03776	COG2364	Membrane
B14_03778	COG1063	alcohol dehydrogenase
B14_03779	COG1278	Cold shock
B14_03780	COG3239	Fatty acid desaturase
B14_03781	COG1476	TRANSCRIPTIONal
B14_03790	COG3091	SprT-like family
B14_03791	COG2409	Drug exporters of the RND superfamily
B14_03791	COG1033	growth of symbiont in host cell
B14_03792	COG1309	transcriptional regulator
B14_03793	COG2183	response to ionizing radiation
B14_03794	COG2208	phosphoserine phosphatase activity
B14_03795	COG1191	sigma factor activity
B14_03796	COG2172	sigma factor antagonist activity
B14_03798	COG2208	phosphoserine phosphatase activity
B14_03799	COG2172	sigma factor antagonist activity
B14_03800	COG1366	Belongs to the anti-sigma-factor antagonist family
B14_03801	COG1366	Belongs to the anti-sigma-factor antagonist family
B14_03802	COG2337	Toxic component of a toxin-antitoxin (TA) module
B14_03803	COG0864	Transcriptional regulator
B14_03804	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B14_03805	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B14_03806	COG0705	Rhomboid family
B14_03807	COG3428	Bacterial PH domain
B14_03808	COG3402	PFAM membrane-flanked domain
B14_03809	COG0513	Belongs to the DEAD box helicase family
B14_03811	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B14_03812	COG1181	Belongs to the D-alanine--D-alanine ligase family
B14_03813	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B14_03816	COG1960	acyl-CoA dehydrogenase activity
B14_03818	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B14_03819	COG1131	(ABC) transporter
B14_03820	COG1301	dicarboxylic acid transport
B14_03821	COG0628	permease
B14_03822	COG3729	General stress protein
B14_03823	COG0662	Cupin 2, conserved barrel domain protein
B14_03825	COG2217	Heavy metal translocating P-type atpase
B14_03826	COG4876	unkown
B14_03827	COG1819	glycosyl
B14_03828	COG1027	Aspartate ammonia-lyase
B14_03829	COG2261	transglycosylase associated protein
B14_03830	COG1914	H( )-stimulated, divalent metal cation uptake system
B14_03831	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B14_03833	COG3397	chitin binding
B14_03834	COG0028	Belongs to the TPP enzyme family
B14_03835	COG0531	amino acid
B14_03836	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B14_03836	COG0551	DNA topoisomerase type I activity
B14_03837	COG1522	sequence-specific DNA binding
B14_03839	COG2814	Major facilitator Superfamily
B14_03840	COG1316	TRANSCRIPTIONal
B14_03842	COG3871	stress protein (general stress protein 26)
B14_03844	COG1917	Cupin 2, conserved barrel domain protein
B14_03845	COG1028	Short-chain dehydrogenase reductase Sdr
B14_03846	COG3711	transcriptional antiterminator
B14_03847	COG0246	Mannitol dehydrogenase
B14_03848	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B14_03849	COG2213	PTS system mannitol-specific
B14_03850	COG2755	lipolytic protein G-D-S-L family
B14_03851	COG1414	Transcriptional regulator
B14_03852	COG1984	allophanate hydrolase subunit 2
B14_03853	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B14_03854	COG4336	lyase activity
B14_03855	COG1914	H( )-stimulated, divalent metal cation uptake system
B14_03856	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B14_03857	COG0561	phosphatase activity
B14_03858	COG3958	Transketolase
B14_03859	COG3959	Transketolase, thiamine diphosphate binding domain
B14_03862	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B14_03864	COG0471	metal ion transport
B14_03865	COG1802	Transcriptional regulator
B14_03866	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B14_03866	COG1587	Uroporphyrinogen-III synthase
B14_03867	COG2146	nitrite reductase [NAD(P)H] activity
B14_03868	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B14_03869	COG0243	molybdopterin cofactor binding
B14_03870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B14_03871	COG1349	DNA-binding transcription factor activity
B14_03872	COG1276	copper resistance
B14_03872	COG2372	response to copper ion
B14_03873	COG4549	nuclear export factor GLE1
B14_03875	COG0697	spore germination
B14_03876	COG1012	belongs to the aldehyde dehydrogenase family
B14_03877	COG0531	amino acid
B14_03878	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B14_03879	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B14_03880	COG0640	Transcriptional regulator
B14_03881	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B14_03882	COG0778	Nitroreductase
B14_03884	COG1309	transcriptional regulator
B14_03885	COG2814	Major facilitator Superfamily
B14_03886	COG4607	ABC-type enterochelin transport system periplasmic component
B14_03887	COG4604	ABC transporter, ATP-binding protein
B14_03888	COG4605	iron ion homeostasis
B14_03889	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B14_03890	COG0527	aspartate kinase activity
B14_03891	COG0840	transmembrane signaling receptor activity
B14_03892	COG3850	Histidine kinase
B14_03892	COG5002	protein histidine kinase activity
B14_03893	COG0745	RESPONSE REGULATOR receiver
B14_03894	COG0577	efflux transmembrane transporter activity
B14_03895	COG1136	(ABC) transporter
B14_03896	COG0789	Transcriptional regulator
B14_03897	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B14_03899	COG0697	spore germination
B14_03901	COG5434	Belongs to the glycosyl hydrolase 28 family
B14_03902	COG3104	oligopeptide transport
B14_03903	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
B14_03904	COG1874	Beta-galactosidase
B14_03905	COG1846	Transcriptional regulator
B14_03905	COG0456	acetyltransferase
B14_03906	COG2271	Major facilitator Superfamily
B14_03907	COG4214	carbohydrate transport
B14_03909	COG4213	ABC transporter substrate-binding protein
B14_03910	COG2207	Transcriptional regulator
B14_03910	COG4753	response regulator
B14_03911	COG2972	Histidine kinase
B14_03915	COG5444	nuclease activity
B14_03925	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B14_03926	COG0163	prenyltransferase activity
B14_03927	COG0583	DNA-binding transcription factor activity
B14_03928	COG0010	Belongs to the arginase family
B14_03929	COG0833	amino acid
B14_03930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B14_03931	COG3829	transcription factor binding
B14_03932	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B14_03933	COG0765	amino acid transport
B14_03934	COG1126	abc transporter atp-binding protein
B14_03940	COG1131	(ABC) transporter
B14_03942	COG2364	Membrane
B14_03944	COG2819	hydrolase of the alpha beta superfamily
B14_03946	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B14_03947	COG0697	spore germination
B14_03948	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B14_03949	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B14_03950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B14_03951	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B14_03952	COG1177	transmembrane transport
B14_03953	COG1176	ABC-type spermidine putrescine transport system, permease component I
B14_03958	COG5444	nuclease activity
B14_03959	COG0840	transmembrane signaling receptor activity
B14_03959	COG3290	protein histidine kinase activity
B14_03960	COG3290	protein histidine kinase activity
B14_03960	COG0840	transmembrane signaling receptor activity
B14_03961	COG0515	serine threonine protein kinase
B14_03961	COG3266	domain, Protein
B14_03962	COG3209	COG3209 Rhs family protein
B14_03964	COG2723	6-phospho-beta-galactosidase activity
B14_03966	COG2249	NAD(P)H dehydrogenase (quinone) activity
B14_03967	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B14_03968	COG0765	amino acid transport
B14_03972	COG3458	cephalosporin-C deacetylase activity
B14_03973	COG0701	Predicted permease
B14_03974	COG3689	TIGRFAM TIGR03943 family protein
B14_03975	COG2508	Transcriptional regulator
B14_03976	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B14_03977	COG1012	belongs to the aldehyde dehydrogenase family
B14_03978	COG0506	proline dehydrogenase activity
B14_03979	COG3541	Predicted nucleotidyltransferase
B14_03980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B14_03981	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B14_03982	COG1113	amino acid transport
B14_03983	COG1280	lysine exporter protein (LysE YggA)
B14_03984	COG1620	l-lactate permease
B14_03985	COG0039	L-malate dehydrogenase activity
B14_03986	COG2223	nitrite transmembrane transporter activity
B14_03987	COG0789	Transcriptional regulator
B14_03989	COG0785	Cytochrome C biogenesis protein
B14_03990	COG3853	Toxic anion resistance protein (TelA)
B14_03994	COG0861	Integral membrane protein TerC family
B14_03995	COG2310	stress, protein
B14_03996	COG2310	stress, protein
B14_03997	COG2310	stress, protein
B14_04001	COG1309	transcriptional regulator
B14_04002	COG1131	(ABC) transporter
B14_04005	COG3883	PFAM NLP P60 protein
B14_04005	COG0791	NLP P60 protein
B14_04006	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B14_04007	COG3773	Cell wall hydrolase
B14_04009	COG1595	DNA-templated transcription, initiation
B14_04011	COG1028	Short-chain dehydrogenase reductase Sdr
B14_04012	COG3591	Belongs to the peptidase S1B family
B14_04016	COG3394	polysaccharide catabolic process
B14_04018	COG1486	melibiose metabolic process
B14_04019	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B14_04020	COG1447	Phosphotransferase system cellobiose-specific component IIA
B14_04021	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B14_04022	COG0277	FAD linked oxidase domain protein
B14_04023	COG0247	lactate metabolic process
B14_04025	COG2261	transglycosylase associated protein
B14_04026	COG1164	Oligoendopeptidase f
B14_04028	COG0456	acetyltransferase
B14_04030	COG1288	antiporter activity
B14_04033	COG1028	Short-chain dehydrogenase reductase Sdr
B14_04034	COG1028	Short-chain dehydrogenase reductase Sdr
B14_04035	COG1942	4-Oxalocrotonate Tautomerase
B14_04036	COG0583	DNA-binding transcription factor activity
B14_04042	COG3012	SEC-C Motif Domain Protein
B14_04042	COG1405	negative regulation of cell septum assembly
B14_04043	COG1714	RDD family
B14_04044	COG0697	spore germination
B14_04049	COG0789	Transcriptional regulator
B14_04053	COG0318	PFAM AMP-dependent synthetase and ligase
B14_04054	COG1846	Transcriptional regulator
B14_04055	COG3173	Aminoglycoside phosphotransferase
B14_04061	COG1131	(ABC) transporter
B14_04062	COG2205	protein histidine kinase activity
B14_04063	COG0745	RESPONSE REGULATOR receiver
B14_04064	COG2721	sulfolactate sulfo-lyase activity
B14_04065	COG2186	Transcriptional regulator
B14_04066	COG4948	Mandelate Racemase Muconate Lactonizing
B14_04067	COG2271	Major facilitator Superfamily
B14_04068	COG1012	belongs to the aldehyde dehydrogenase family
B14_04069	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B14_04070	COG0805	protein transport
B14_04071	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B14_04072	COG3540	Alkaline phosphatase
B14_04077	COG0784	Response regulator, receiver
B14_04078	COG4191	Histidine kinase
B14_04079	COG2066	Belongs to the glutaminase family
B14_04080	COG1115	amino acid carrier protein
B14_04081	COG2205	protein histidine kinase activity
B14_04083	COG2323	membrane
B14_04084	COG0789	Transcriptional regulator
B14_04085	COG1263	PTS System
B14_04085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_04085	COG2190	(PTS) system
B14_04087	COG2040	homocysteine
B14_04088	COG0833	amino acid
B14_04090	COG4257	antibiotic catabolic process
B14_04093	COG4213	ABC transporter substrate-binding protein
B14_04094	COG0840	transmembrane signaling receptor activity
B14_04095	COG0371	Dehydrogenase
B14_04099	COG1917	Cupin 2, conserved barrel domain protein
B14_04099	COG2207	Transcriptional regulator
B14_04100	COG0697	spore germination
B14_04105	COG4682	membrane
B14_04106	COG1283	sodium-dependent phosphate transmembrane transporter activity
B14_04110	COG0477	Major facilitator Superfamily
B14_04111	COG1331	Highly conserved protein containing a thioredoxin domain
B14_04114	COG0457	Tetratricopeptide repeat
B14_04115	COG0457	Tetratricopeptide repeat
B14_04119	COG0791	NLP P60 protein
B14_04119	COG0741	lytic transglycosylase activity
B14_04120	COG5644	endopeptidase inhibitor activity
B14_04123	COG0433	COG0433 Predicted ATPase
B14_04130	COG2946	Replication initiation factor
B14_04131	COG1674	ftsk spoiiie
B14_04137	COG1396	sequence-specific DNA binding
B14_04138	COG2856	Zn peptidase
B14_04141	COG1331	Highly conserved protein containing a thioredoxin domain
B14_04142	COG1331	Highly conserved protein containing a thioredoxin domain
B14_04146	COG2211	Major facilitator Superfamily
B14_04147	COG3290	protein histidine kinase activity
B14_04148	COG2851	Citrate transporter
B14_04149	COG1113	amino acid transport
B14_04150	COG1011	Hydrolase
B14_04155	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B14_04156	COG1132	(ABC) transporter
B14_04158	COG2814	Major facilitator Superfamily
B14_04159	COG0640	Transcriptional regulator
B14_04160	COG1725	Transcriptional regulator
B14_04164	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B14_04165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B14_04166	COG4856	YbbR-like protein
B14_04167	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B14_04168	COG5662	AntiSigma factor
B14_04169	COG1595	DNA-templated transcription, initiation
B14_04176	COG1683	Conserved Protein
B14_04177	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B14_04178	COG1737	Transcriptional regulator
B14_04179	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B14_04179	COG1263	PTS System
B14_04180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B14_04181	COG1472	Belongs to the glycosyl hydrolase 3 family
B14_04182	COG3876	Protein conserved in bacteria
B14_04185	COG0385	Bile acid
B14_04187	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B14_04194	COG0726	polysaccharide deacetylase
B14_04195	COG2194	sulfuric ester hydrolase activity
B14_04197	COG0489	protein tyrosine kinase activity
B14_04198	COG0860	N-Acetylmuramoyl-L-alanine amidase
B14_04200	COG2318	DinB family
B14_04201	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B14_04202	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B14_04203	COG0101	tRNA pseudouridine synthase activity
B14_04204	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B14_04205	COG1122	ATPase activity
B14_04206	COG1122	ATPase activity
B14_04207	COG0203	ribosomal protein L17
B14_04208	COG0202	RNA polymerase activity
B14_04209	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B14_04210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B14_04211	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B14_04212	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B14_04213	COG2163	COG2163 Ribosomal protein L14E L6E L27E
B14_04214	COG0024	Methionine aminopeptidase
B14_04215	COG0563	adenylate kinase activity
B14_04216	COG0201	protein transport
B14_04217	COG0200	Binds to the 23S rRNA
B14_04218	COG1841	ribosomal large subunit assembly
B14_04219	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B14_04220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B14_04221	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B14_04222	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B14_04223	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B14_04224	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B14_04225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B14_04226	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B14_04227	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B14_04228	COG0255	Belongs to the universal ribosomal protein uL29 family
B14_04229	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B14_04230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B14_04231	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B14_04232	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B14_04233	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B14_04234	COG0089	rRNA binding
B14_04235	COG0088	Forms part of the polypeptide exit tunnel
B14_04236	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B14_04237	COG0051	transcription antitermination factor activity, RNA binding
B14_04238	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B14_04239	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B14_04240	COG0049	tRNA binding
B14_04241	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B14_04242	COG1358	cellular component organization or biogenesis
B14_04243	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B14_04244	COG0085	RNA polymerase activity
B14_04245	COG2813	Specifically methylates the guanine in position
B14_04246	COG0222	ribosome binding
B14_04247	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B14_04248	COG0081	regulation of translation
B14_04249	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B14_04250	COG0250	Participates in transcription elongation, termination and antitermination
B14_04253	COG3688	RNA-binding protein containing a PIN domain
B14_04254	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B14_04255	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B14_04256	COG0215	cysteine-tRNA ligase activity
B14_04257	COG1045	serine acetyltransferase
B14_04258	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B14_04259	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B14_04260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B14_200064	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B14_200066	COG3584	3D domain protein
B14_200072	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B14_200095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B14_200105	COG0210	DNA helicase
B14_200107	COG0305	Participates in initiation and elongation during chromosome replication
B14_200107	COG0358	DNA primase activity
B14_200118	COG0592	DNA-directed DNA polymerase activity
B14_200125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B14_200129	COG5444	nuclease activity
B14_200132	COG2814	Major facilitator Superfamily
B14_200133	COG0457	Tetratricopeptide repeat
B14_200146	COG0194	GDP metabolic process
B14_200151	COG5632	N-Acetylmuramoyl-L-alanine amidase
B14_200163	COG2131	deaminase
B14_200167	COG4112	unkown
B14_200168	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B14_200170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B14_200206	COG0791	NLP P60 protein
B14_200206	COG0741	lytic transglycosylase activity