locus-tag class description B34_00004 ENOG4105BZU Histidine kinase B34_00005 ENOG4107ZYR domain protein B34_00007 ENOG4105CN5 Metallo-Beta-Lactamase B34_00009 ENOG4108X4Q Hydrolase B34_00010 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B34_00014 ENOG4105CPP Dehydrogenase, E1 component B34_00015 ENOG4105C7S Dehydrogenase B34_00016 ENOG4107QN2 dihydrolipoyl dehydrogenase B34_00020 ENOG4105CXN decarboxylase B34_00021 ENOG4105WBI UPF0223 protein B34_00024 ENOG4105ECY inositol monophosphatase B34_00031 ENOG4105CI3 gtp-binding protein typa B34_00032 ENOG4105QA2 B34_00033 ENOG4108INS Transcriptional regulator B34_00034 ENOG4107SCK Monooxygenase B34_00037 ENOG4108IAB Phoh family B34_00039 ENOG4105CSV Glutaminase B34_00040 ENOG4105ZPI UPF0358 protein B34_00041 ENOG4105CNI cell division protein FtsW B34_00042 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) B34_00044 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) B34_00046 ENOG4105BZ9 Cytochrome C oxidase, subunit I B34_00047 ENOG4105CCU oxidase (Subunit III) B34_00048 ENOG41064X9 cytochrome C oxidase subunit IV B34_00051 ENOG41080XQ Signal transduction protein with cbs domains B34_00052 ENOG4106UY4 Inherit from COG: Scp-like extracellular B34_00058 ENOG4106H78 methyltransferase B34_00059 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) B34_00060 ENOG4105H20 Sporulation integral membrane protein YlbJ B34_00061 ENOG41063PX domain protein B34_00062 ENOG4105CDE UPF0348 protein B34_00063 ENOG4105KNH Nucleic acid-binding protein B34_00064 ENOG41067VY 50S ribosomal protein L32 B34_00068 ENOG41074B2 UPF0747 protein B34_00069 ENOG4108V6E Cell division protein mraZ B34_00070 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) B34_00072 ENOG4105CJN penicillin-binding protein B34_00073 ENOG4105CJN penicillin-binding protein B34_00075 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) B34_00076 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) B34_00077 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) B34_00078 ENOG4105CNI cell division protein FtsW B34_00079 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B34_00080 ENOG4105D4A Cell wall formation (By similarity) B34_00081 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) B34_00082 ENOG4108R2U division initiation protein B34_00084 ENOG4105K67 small basic protein B34_00085 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) B34_00086 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) B34_00090 ENOG4105FFI sigma-e processing peptidase spoiiga B34_00091 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B34_00093 ENOG4105DKW ABC transporter B34_00094 ENOG4105DHI Methyltransferase B34_00095 ENOG4105WR5 sporulation protein, YlmC YmxH family B34_00096 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase B34_00097 ENOG4105DFA alanine racemase domain protein B34_00098 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) B34_00099 ENOG41067XK integral membrane protein B34_00100 ENOG4105DBK s4 domain protein B34_00104 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) B34_00105 ENOG4105C34 Pseudouridine synthase B34_00106 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) B34_00108 ENOG4105CXT aspartate transcarbamylase B34_00109 ENOG4105CD3 dihydroorotase B34_00110 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain B34_00111 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain B34_00112 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) B34_00113 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) B34_00114 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) B34_00117 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) B34_00121 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B34_00122 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B34_00123 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B34_00124 ENOG4105F23 Fibronectin-binding protein B34_00126 ENOG4105DSJ YicC domain protein B34_00127 ENOG4105KC4 UPF0296 protein B34_00128 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) B34_00129 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) B34_00130 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase B34_00131 ENOG4105C25 Primosomal protein n' B34_00132 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B34_00133 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) B34_00134 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B B34_00135 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs B34_00136 ENOG4108ZF3 Phosphatase B34_00137 ENOG4105D9P serine threonine protein kinase B34_00138 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) B34_00139 ENOG4105DJV ribulose-phosphate 3-epimerase B34_00140 ENOG4105FJ0 thiamine B34_00141 ENOG4105VB9 50S ribosomal protein l28 B34_00142 ENOG4108ZAA Alkaline-shock protein B34_00143 ENOG4105DP4 dak2 domain fusion protein ylov B34_00145 ENOG4105EJQ L-serine dehydratase B34_00146 ENOG4105CB5 ATP-dependent DNA helicase recG B34_00147 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) B34_00148 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) B34_00149 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase B34_00150 ENOG4105CHR reductase B34_00151 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) B34_00152 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) B34_00153 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) B34_00154 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) B34_00155 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) B34_00157 ENOG4105K5M 30s ribosomal protein S16 B34_00158 ENOG4108BW8 UPF0109 protein B34_00160 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) B34_00161 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) B34_00162 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) B34_00163 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) B34_00164 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B34_00166 ENOG4105VM1 flagellar B34_00167 ENOG4105CMV Succinyl-CoA synthetase subunit beta B34_00168 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha B34_00169 ENOG4105C79 DNA protecting protein DprA B34_00170 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) B34_00171 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) B34_00172 ENOG4108HE4 integrase family B34_00173 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) B34_00174 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) B34_00175 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) B34_00177 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) B34_00178 ENOG4108ZC9 flagellar basal-body rod protein flgc B34_00179 ENOG4105VQ0 flagellar hook-basal body complex protein fliE B34_00180 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) B34_00181 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B34_00184 ENOG4106YF4 Flagellar biosynthesis chaperone B34_00186 ENOG410696Y Flagellar hook-length control protein B34_00187 ENOG410822I Flagellar hook capping protein B34_00188 ENOG4108JQA flagellar B34_00190 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B34_00191 ENOG4105DD5 Flagellar motor switch protein B34_00192 ENOG4107YTP response regulator receiver protein B34_00194 ENOG4105CN7 Flagellar biosynthetic protein FliP B34_00195 ENOG4105VS8 Flagellar biosynthetic protein fliq B34_00196 ENOG4105D19 Role in flagellar biosynthesis (By similarity) B34_00197 ENOG4105D00 flagellar biosynthetic protein flhB B34_00198 ENOG4105D7B Flagellar biosynthesis protein flha B34_00199 ENOG4105FZW flagellar biosynthesis regulator FlhF B34_00201 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) B34_00202 ENOG4105CBS Chea signal transduction histidine kinase B34_00203 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis B34_00205 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) B34_00206 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B34_00208 ENOG4105CE9 30S ribosomal protein S2 B34_00209 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) B34_00211 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) B34_00212 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) B34_00213 ENOG4105KNE Phosphatidate cytidylyltransferase B34_00215 ENOG4105DZP Membrane-associated zinc metalloprotease B34_00217 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B34_00220 ENOG4105CYP glycoside hydrolase, family B34_00223 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) B34_00224 ENOG4105CHV Transcription elongation factor NusA B34_00225 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination B34_00226 ENOG4105VHM ribosomal protein B34_00227 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) B34_00228 ENOG4105W7A Protein of unknown function (DUF503) B34_00229 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) B34_00230 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) B34_00231 ENOG4105DTN riboflavin biosynthesis protein ribF B34_00232 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) B34_00233 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) B34_00235 ENOG4105C1V Peptidase, M16 B34_00237 ENOG4105E35 Dipicolinate synthase subunit A B34_00238 ENOG4108S0H Dipicolinic acid synthetase, b subunit B34_00239 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B34_00241 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B34_00243 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit B34_00245 ENOG4105CNU cell division protein FtsK B34_00246 ENOG4105FDP GntR family transcriptional regulator B34_00250 ENOG4108RKS Short-chain dehydrogenase reductase Sdr B34_00251 ENOG4105XZV Protein of unknown function (DUF3243) B34_00254 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase B34_00255 ENOG4105CEV competence damage-inducible protein B34_00256 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) B34_00258 ENOG4105D48 metallophosphoesterase B34_00259 ENOG4105MCT stage V sporulation protein S B34_00260 ENOG4108IGT Dipeptidase B34_00261 ENOG4105CPQ Dehydrogenase B34_00262 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) B34_00263 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B34_00266 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) B34_00267 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) B34_00269 ENOG4107EV6 Inherit from COG: YD repeat protein B34_00272 ENOG4105CKI cobalamin synthesis protein B34_00274 ENOG4107TCE N-acetyltransferase B34_00278 ENOG4105XPP Protein of unknown function (DUF1275) B34_00279 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) B34_00280 ENOG4108J8C transporter major facilitator family protein B34_00281 ENOG4108J8C transporter major facilitator family protein B34_00282 ENOG4105U6C Alpha beta hydrolase fold protein B34_00284 ENOG41080BT SNARE associated Golgi B34_00285 ENOG4105FQP Beta-lactamase B34_00286 ENOG41087PP glycosyltransferase MGT family B34_00287 ENOG4107QTZ amino acid B34_00290 ENOG4105VRS hydrolase family 18 B34_00291 ENOG4105VRS hydrolase family 18 B34_00292 ENOG4105M4P Tetr family transcriptional regulator B34_00293 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein B34_00294 ENOG4107S9F NmrA family B34_00296 ENOG4108X3M OsmC Ohr family protein B34_00297 ENOG4107E54 Small Multidrug Resistance protein B34_00301 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) B34_00302 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) B34_00304 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) B34_00305 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B34_00306 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B34_00307 ENOG4105U6W MutT NUDIX family protein B34_00310 ENOG4108UNV SUF system FeS assembly protein, NifU family B34_00311 ENOG4105G5W regulator Fur family B34_00312 ENOG4105DRR Transcriptional regulator, GntR family B34_00319 ENOG4105PF9 Transcriptional regulator B34_00328 ENOG4107EV6 Inherit from COG: YD repeat protein B34_00332 ENOG4106F1P AAA ATPase, central domain protein B34_00334 ENOG4105C8Q Methyl-accepting chemotaxis B34_00336 ENOG4105CHR reductase B34_00337 ENOG4106BHF B34_00338 ENOG4106ANW SMI1_KNR4 B34_00339 ENOG4106ANW SMI1_KNR4 B34_00340 ENOG4106ANW SMI1_KNR4 B34_00350 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B34_00356 ENOG4105E4C Lytic transglycosylase catalytic B34_00357 ENOG4105E4C Lytic transglycosylase catalytic B34_00376 ENOG41068G1 B34_00397 ENOG4105K70 DNA-binding protein B34_00408 ENOG4108NE4 B34_00420 ENOG4107NTZ B34_00434 ENOG4106HHG B34_00437 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B34_00440 ENOG4107D0N B34_00450 ENOG4105C7H Helicase, RecD TraA family B34_00461 ENOG4108J9Q DNA ligase B34_00476 ENOG4106YR8 B34_00477 ENOG41088HM B34_00479 ENOG4106PTB DnaB-like helicase C terminal domain B34_00480 ENOG4106IVX B34_00482 ENOG4106J9J DNA polymerase B34_00484 ENOG4106J9J DNA polymerase B34_00486 ENOG4106J9J DNA polymerase B34_00501 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) B34_00502 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B34_00503 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B34_00506 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B34_00508 ENOG4106ITI Glutaredoxin B34_00512 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) B34_00520 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) B34_00529 ENOG4108UV1 cellular component movement B34_00531 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) B34_00534 ENOG4106F1P AAA ATPase, central domain protein B34_00535 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B34_00536 ENOG4105CXI aluminum resistance protein B34_00537 ENOG4105KV4 Transcriptional regulator B34_00538 ENOG4105C5F glutamine synthetase B34_00559 ENOG4108MK9 spermidine N(1)-acetyltransferase B34_00562 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B34_00567 ENOG41062JF Transcriptional regulator B34_00568 ENOG41090MY MarR family Transcriptional regulator B34_00569 ENOG4108TVJ Nitroreductase B34_00570 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase B34_00571 ENOG4107XWI flavin reductase domain protein, FMN-binding B34_00572 ENOG4105CS1 NAD(P)H quinone oxidoreductase B34_00575 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) B34_00576 ENOG4105WFK nuclease B34_00577 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B34_00579 ENOG4108SVB resolvase B34_00580 ENOG4105VPS UPF0291 protein B34_00581 ENOG4105CV1 Transketolase (EC 2.2.1.1) B34_00583 ENOG4105VXM UPF0154 protein B34_00585 ENOG4107QIV Cytochrome c biogenesis protein B34_00590 ENOG4108I0Z Aconitate hydratase B34_00591 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B34_00596 ENOG4105MI2 B34_00599 ENOG4105W8X HesB YadR YfhF-family protein B34_00600 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) B34_00601 ENOG4105K4P CoA-binding domain protein B34_00602 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B34_00604 ENOG4105CMD Transcriptional regulator, GntR family B34_00607 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) B34_00608 ENOG4107QNK )-transporter B34_00609 ENOG4105CHR reductase B34_00615 ENOG4105R3A Nitrate reductase B34_00616 ENOG4108IUE nitrate reductase beta subunit B34_00623 ENOG4107V6Q Cyclic nucleotide-binding domain B34_00626 ENOG4105IJJ transcriptional regulator, crp fnr family B34_00627 ENOG4105DSQ Nitric oxide reductase B34_00628 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) B34_00629 ENOG4106U2H Protein of unknown function (DUF1360) B34_00630 ENOG4107QWR cellulase (EC 3.2.1.4) B34_00632 ENOG4108428 Inherit from COG: -acetyltransferase B34_00634 ENOG4107UWP Major facilitator superfamily MFS_1 B34_00635 ENOG4108M26 parallel beta-helix repeat protein B34_00637 ENOG4105DQ4 alcohol dehydrogenase B34_00638 ENOG4105VUF Transcriptional regulator B34_00643 ENOG41060WC Enoyl-CoA hydratase B34_00644 ENOG4105C26 Dehydrogenase B34_00645 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B34_00646 ENOG4105C1G acyl-Coa dehydrogenase B34_00647 ENOG4105DG6 mannose-6-phosphate isomerase B34_00648 ENOG4105DM4 PTS System B34_00655 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B34_00656 ENOG4105DMW Dehydrogenase reductase B34_00657 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) B34_00659 ENOG4105CG6 trap dicarboxylate transporter dctm subunit B34_00660 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter B34_00661 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit B34_00662 ENOG4107KJX Transcriptional regulator B34_00663 ENOG4108UXE Protein tyrosine phosphatase B34_00664 ENOG4107R5R arsenical pump membrane protein B34_00665 ENOG41082YX Transcriptional regulator, arsr family B34_00666 ENOG4105CZ9 Domain of unknown function (DU1801) B34_00668 ENOG4105CSC Glucose uptake protein B34_00669 ENOG4105F32 YngK protein B34_00672 ENOG4105F1A Pyruvate formate-lyase B34_00674 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family B34_00675 ENOG4105H67 Protein of unknown function (DUF421) B34_00676 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B34_00678 ENOG4108QY0 Membrane B34_00681 ENOG4105CZ3 stage V sporulation protein ad B34_00682 ENOG41090VF Stage v sporulation protein ac B34_00685 ENOG4105WEF catalase B34_00689 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B34_00698 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B34_00699 ENOG4107QX3 carboxylase B34_00700 ENOG4105E39 Enoyl-CoA hydratase B34_00701 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase B34_00702 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit B34_00703 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B34_00704 ENOG4105CEY Amp-dependent synthetase and ligase B34_00705 ENOG4105C1G acyl-Coa dehydrogenase B34_00706 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B34_00707 ENOG4105KVH Transcriptional regulator B34_00708 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) B34_00709 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) B34_00712 ENOG4105H67 Protein of unknown function (DUF421) B34_00714 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) B34_00715 ENOG41061P3 phosphosulfolactate synthase B34_00717 ENOG4105DIA mandelate racemase muconate lactonizing B34_00718 ENOG4105DIA mandelate racemase muconate lactonizing B34_00719 ENOG4107RCC Major Facilitator Superfamily B34_00723 ENOG4105BZ8 glutamate synthase B34_00724 ENOG4105CBC glutamate synthase B34_00725 ENOG4105C5Q Transcriptional regulator B34_00731 ENOG4105BZ1 (ABC) transporter B34_00734 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B34_00735 ENOG4105C0R drug resistance transporter emrb qaca subfamily B34_00736 ENOG4108J2R molybdopterin oxidoreductase B34_00739 ENOG4108Q8B Spore germination protein B34_00740 ENOG4108NHD germination protein B34_00741 ENOG4108Q8B Spore germination protein B34_00742 ENOG4108Q8B Spore germination protein B34_00745 ENOG4105C8Q Methyl-accepting chemotaxis B34_00746 ENOG4108Z7R Chaperone CsaA B34_00747 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B34_00749 ENOG4108RZE Tetr family transcriptional regulator B34_00751 ENOG4105T9C HD domain B34_00753 ENOG4105FVX B34_00757 ENOG4108W8B Beta-lactamase domain protein B34_00760 ENOG4105D29 Helix-turn-helix type 11 domain protein B34_00762 ENOG4105KTU Transcriptional regulator, arsr family B34_00765 ENOG4105CUB amino acid B34_00767 ENOG4105C5E polysaccharide biosynthesis protein B34_00770 ENOG4107T8Q Glycosyl transferase (Group 1 B34_00771 ENOG4105DQ6 Transposase B34_00773 ENOG4108SJC Membrane B34_00776 ENOG4107RUZ Sss sodium solute transporter superfamily B34_00777 ENOG41069ER domain protein B34_00778 ENOG4105C9U ATP-dependent DNA helicase RecQ B34_00783 ENOG4105UNS Pfam:DUF419 B34_00787 ENOG4108IEG Formate dehydrogenase Alpha subunit B34_00797 ENOG4108NHD germination protein B34_00800 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) B34_00803 ENOG4107S9D Alpha beta hydrolase B34_00807 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) B34_00809 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B34_00810 ENOG4105ST3 Transcriptional regulator B34_00814 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) B34_00815 ENOG4105SCY DNAK suppressor B34_00818 ENOG4105C26 Dehydrogenase B34_00822 ENOG4105EWU Squalene--hopene cyclase B34_00823 ENOG4105EWU Squalene--hopene cyclase B34_00824 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B34_00826 ENOG4105C8J )-transporter B34_00827 ENOG4105C09 Bile acid B34_00828 ENOG4105C7S Dehydrogenase B34_00829 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 B34_00830 ENOG4107T89 von Willebrand factor, type A B34_00831 ENOG4105GMT ATPase associated with various cellular activities aaa_5 B34_00833 ENOG4105K4H Nlp p60 protein B34_00838 ENOG4105FR1 rard protein B34_00841 ENOG4108YQE rare lipoprotein a B34_00843 ENOG4107EXU Short-chain dehydrogenase reductase Sdr B34_00846 ENOG4105FBA Phospholipase Carboxylesterase B34_00848 ENOG4105E1V na solute symporter B34_00852 ENOG4108VXD carboxy-peptidase B34_00853 ENOG4105D3A purine nucleoside phosphorylase DeoD-type B34_00854 ENOG4108PJD permease B34_00857 ENOG4106Z5R B34_00858 ENOG410841Q phosphoesterase PA-phosphatase related protein B34_00862 ENOG4105VSD UPF0346 protein B34_00864 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein B34_00865 ENOG4108TSC N-acetyltransferase B34_00866 ENOG4107S4Y M20 DapE family protein YgeY B34_00869 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B34_00872 ENOG4105E0X reductase B34_00876 ENOG4105BZU Histidine kinase B34_00880 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) B34_00881 ENOG41090WU lipolytic protein G-D-S-L family B34_00882 ENOG4108KF3 Electron transport protein SCO1 SenC B34_00885 ENOG4105C7B Threonine dehydratase B34_00887 ENOG4108UT2 hemolysin iii B34_00889 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) B34_00893 ENOG4107YX5 Pfam:DUF548 B34_00895 ENOG4105C01 Dihydroxy-acid dehydratase B34_00898 ENOG4108V06 Glutathione peroxidase B34_00899 ENOG4105CKU formyltetrahydrofolate synthetase B34_00900 ENOG4105CVG Homoserine O-transsuccinylase B34_00901 ENOG4108QBV Monogalactosyldiacylglycerol synthase B34_00909 ENOG41081VK Ribonuclease B34_00913 ENOG410890F Dynamin family B34_00915 ENOG41065KQ synthase B34_00916 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B34_00917 ENOG4105C2W permease B34_00918 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) B34_00919 ENOG4105CTD carboxy-peptidase B34_00920 ENOG4105DVT helicase B34_00923 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) B34_00924 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) B34_00925 ENOG4108UKS UPF0398 protein B34_00928 ENOG4107X2U Inherit from COG: Exonuclease-like protein B34_00929 ENOG4108I5C dEAD DEAH box helicase B34_00938 ENOG4105BZ4 penicillin-binding protein B34_00940 ENOG4105CSM endonuclease III B34_00943 ENOG4105CHM Aminotransferase B34_00945 ENOG4105YAC B34_00946 ENOG4105DVT helicase B34_00947 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) B34_00948 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) B34_00949 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) B34_00951 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate B34_00952 ENOG4105CPK Glycosyl transferase (Group 1 B34_00953 ENOG4105FJR Lmbe family B34_00954 ENOG4108Z5K methylglyoxal synthase B34_00955 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) B34_00956 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase B34_00957 ENOG4108JYZ YitT family B34_00961 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) B34_00964 ENOG4108SXZ UPF0302 protein B34_00965 ENOG41068YB TPR repeat-containing protein B34_00968 ENOG4105CIH Imidazole acetol-phosphate transaminase B34_00969 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) B34_00970 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) B34_00972 ENOG4105DK0 Indole-3-glycerol phosphate synthase B34_00973 ENOG4108I0Q anthranilate phosphoribosyltransferase B34_00974 ENOG4105CRQ synthase (Component I) B34_00975 ENOG4105KHN chorismate mutase B34_00976 ENOG4105D49 3-dehydroquinate synthase B34_00977 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase B34_00978 ENOG4105BZU Histidine kinase B34_00979 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) B34_00980 ENOG4105EAH synthase B34_00981 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B34_00982 ENOG4105XXQ heptaprenyl diphosphate synthase component I B34_00984 ENOG4105EUJ GTP cyclohydrolase i B34_00985 ENOG4105K70 DNA-binding protein B34_00986 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) B34_00990 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase B34_00991 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) B34_00992 ENOG41065D1 B34_00993 ENOG4105S2F B34_00996 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) B34_00997 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) B34_00998 ENOG4105CAT Cytidine monophosphate kinase B34_01000 ENOG4105MSI germination protein ypeb B34_01003 ENOG4105HDK L-asparaginase B34_01004 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase B34_01007 ENOG4107RGJ metallophosphoesterase B34_01010 ENOG4105I7S Abortive infection protein B34_01011 ENOG4105C9U ATP-dependent DNA helicase RecQ B34_01012 ENOG4105T7X B34_01014 ENOG4108SAX Membrane B34_01015 ENOG4108JQ1 Dehydrogenase B34_01016 ENOG4105DR5 peptidase B34_01022 ENOG4105US7 Histidine kinase B34_01023 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B34_01024 ENOG4105BZU Histidine kinase B34_01025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B34_01026 ENOG4105CRE cytochrome C B34_01027 ENOG4107TWT Cytochrome c biogenesis protein B34_01028 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B34_01029 ENOG4105FE9 pseudouridine synthase B34_01031 ENOG4108JIC nucleoside recognition domain protein B34_01032 ENOG4105DZ1 carboxypeptidase B34_01034 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) B34_01035 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) B34_01039 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) B34_01040 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) B34_01041 ENOG4108R6K riboflavin synthase, subunit alpha B34_01042 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) B34_01044 ENOG4105MEW serine threonine protein phosphatase B34_01045 ENOG4105MYT Heat shock protein B34_01048 ENOG4107ZE5 PPIases accelerate the folding of proteins B34_01049 ENOG4105PTM secreted protein B34_01050 ENOG4105K7W phage-related replication protein B34_01051 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) B34_01054 ENOG4105G6R Stage v sporulation protein ae B34_01056 ENOG4105CZ3 stage V sporulation protein ad B34_01057 ENOG41090VF Stage v sporulation protein ac B34_01060 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B34_01061 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) B34_01062 ENOG41082AN stage II sporulation protein B34_01063 ENOG4105DZ1 carboxypeptidase B34_01064 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) B34_01065 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) B34_01066 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B34_01068 ENOG4105I3K Ferric uptake regulator, Fur family B34_01069 ENOG4105MZ9 stage II sporulation protein m B34_01070 ENOG4105CK1 PTS System B34_01072 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease B34_01073 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease B34_01076 ENOG4107YB6 acetyltransferase, (GNAT) family B34_01078 ENOG4108YZ4 nudix hydrolase B34_01080 ENOG4105PF9 Transcriptional regulator B34_01082 ENOG4105CPC Aldo Keto reductase B34_01086 ENOG4106HZJ B34_01088 ENOG4105RHY Pfam:UPF0157 B34_01089 ENOG4105KAC Antibiotic biosynthesis monooxygenase B34_01090 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold B34_01092 ENOG4107RRN ABC transporter substrate-binding protein B34_01093 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B34_01094 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B34_01095 ENOG4108RZA ABC transporter B34_01096 ENOG4107R73 Mate efflux family protein B34_01100 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B34_01102 ENOG4105E5W Transporter B34_01103 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase B34_01106 ENOG4105DA5 (ABC) transporter B34_01110 ENOG4105K7W phage-related replication protein B34_01111 ENOG4108IXY short-chain dehydrogenase reductase B34_01112 ENOG41069FQ Metallo-beta-lactamase superfamily B34_01113 ENOG4105II7 pyrroline-5-carboxylate reductase B34_01115 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B34_01117 ENOG4105WDJ 50S ribosomal protein L33 B34_01118 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) B34_01119 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase B34_01123 ENOG4108TZY GntR Family Transcriptional Regulator B34_01124 ENOG4105CS2 ec 3.2.1.21 B34_01125 ENOG4105CK1 PTS System B34_01126 ENOG4105VCP PTS System B34_01127 ENOG4105VZJ PTS System B34_01129 ENOG4105G6Z alkaline phosphatase B34_01130 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B34_01131 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) B34_01132 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B34_01134 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) B34_01135 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B34_01136 ENOG4108HNZ carboxyl transferase B34_01137 ENOG4108QEG Membrane B34_01138 ENOG4105CDA abc transporter atp-binding protein B34_01139 ENOG4105E5Q amino acid AbC transporter B34_01140 ENOG4108HW3 (ABC) transporter B34_01142 ENOG4108Y6J UPF0403 protein B34_01143 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) B34_01144 ENOG4105C7S Dehydrogenase B34_01145 ENOG4105CPP Dehydrogenase, E1 component B34_01148 ENOG4105CKM Branched-chain carboxylic acid kinase B34_01149 ENOG4107RDP Dehydrogenase B34_01151 ENOG4108JUB Transcriptional regulator B34_01152 ENOG4106CCJ Protein of unknown function (DUF2627) B34_01153 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B34_01154 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B34_01156 ENOG4105D7W serine acetyltransferase B34_01158 ENOG4107QQR Sporulation B34_01159 ENOG4105S1Z Stage IV sporulation protein B B34_01160 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) B34_01161 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) B34_01162 ENOG4105DX0 Hemolysin A B34_01163 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) B34_01164 ENOG4105CTB Polyprenyl synthetase B34_01165 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B34_01166 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B34_01167 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) B34_01168 ENOG4105M7K Involved in the transcription termination process (By similarity) B34_01169 ENOG4108ZSR alkaline shock protein B34_01170 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B34_01174 ENOG410644B Stage III sporulation protein af B34_01176 ENOG4105KQ4 Stage iii sporulation protein ad B34_01177 ENOG4108CQH stage III sporulation protein AC B34_01178 ENOG4105KR5 Stage iii sporulation protein B34_01179 ENOG4105CD2 stage iii sporulation protein aa B34_01181 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) B34_01182 ENOG4105DC7 peptidase M24 B34_01183 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) B34_01185 ENOG4105CBJ Metal-dependent enzyme B34_01188 ENOG4105KST dependent repressor B34_01189 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) B34_01190 ENOG4105WZW rhodanese family B34_01192 ENOG4107SQ8 Glycine betaine B34_01193 ENOG4108IJ7 Glycine betaine B34_01194 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor B34_01196 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) B34_01197 ENOG4105C0D helicase B34_01202 ENOG4105VFR signal peptidase B34_01209 ENOG4106855 Competence protein B34_01224 ENOG410906S phage-like element pbsx protein xkdt B34_01225 ENOG41066EA baseplate J family protein B34_01226 ENOG4105MFU Protein of unknown function (DUF2634) B34_01228 ENOG4105X7F B34_01229 ENOG4108WZM domain protein B34_01230 ENOG4108FKH Transglycosylase SLT domain B34_01230 ENOG4108FKH Transglycosylase SLT domain B34_01232 ENOG4105MTC XkdN-like protein B34_01234 ENOG4105FR7 XkdM protein, phage-like element PBSX B34_01235 ENOG4105PQS phage protein B34_01237 ENOG41060SN B34_01244 ENOG4106CGH Phage Mu protein F like protein B34_01245 ENOG4108MDF Phage Portal Protein B34_01246 ENOG4105IG6 Phage terminase, large subunit B34_01252 ENOG4107EV6 Inherit from COG: YD repeat protein B34_01260 ENOG4105UA4 acetyltransferase B34_01265 ENOG4105QBX endodeoxyribonuclease RusA B34_01269 ENOG4105CDU Replicative dna helicase B34_01273 ENOG4108PNI recT protein B34_01274 ENOG4108NF7 phage-type endonuclease B34_01284 ENOG410635T phage-like element pbsx protein B34_01293 ENOG4105C5X domain protein B34_01300 ENOG4105E0M Sulfatase B34_01303 ENOG4107ZXI Rhomboid family B34_01305 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase B34_01306 ENOG4105WDJ 50S ribosomal protein L33 B34_01310 ENOG41068DG YceG-like family B34_01311 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B34_01312 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B34_01313 ENOG4105E2Z phosphate ABC transporter (Permease B34_01314 ENOG4105C8U phosphate abc transporter B34_01315 ENOG4105CVA phosphate B34_01316 ENOG4107RF6 penicillin-binding protein B34_01318 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B34_01319 ENOG4105SXS Protein of unknown function (DUF456) B34_01322 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) B34_01323 ENOG41063Y9 B34_01324 ENOG4108U5J '-nucleotidase B34_01325 ENOG4105N80 Ferric uptake regulator, Fur family B34_01326 ENOG4105FAV ABC, transporter B34_01327 ENOG4105FDK ABC transporter B34_01328 ENOG4108JYZ YitT family B34_01329 ENOG41069ZM Protein of unknown function (DUF2624) B34_01330 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) B34_01333 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) B34_01334 ENOG4105EGD dinuclear metal center protein, YbgI family B34_01336 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) B34_01337 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) B34_01350 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B34_01351 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) B34_01353 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) B34_01355 ENOG4105C38 Glycyl-tRNA synthetase beta subunit B34_01356 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit B34_01357 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) B34_01359 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) B34_01360 ENOG4105KG3 cytidine deaminase B34_01361 ENOG4107YR5 Diacylglycerol kinase B34_01362 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) B34_01363 ENOG4105CTJ Metal Dependent Phosphohydrolase B34_01364 ENOG4105C9A Phoh family B34_01365 ENOG4105EI1 sporulation protein yqfd B34_01366 ENOG41068P3 sporulation protein YqfC B34_01368 ENOG4105DI5 UPF0365 protein B34_01369 ENOG4105F7J membrane-bound serine protease B34_01370 ENOG4105KTH gatB Yqey B34_01371 ENOG4105VCC 30S ribosomal protein S21 B34_01373 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) B34_01374 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B34_01375 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) B34_01376 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) B34_01377 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) B34_01378 ENOG4105CFG Acts as a chaperone (By similarity) B34_01379 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ B34_01380 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) B34_01381 ENOG4105CSA Coproporphyrinogen iii oxidase B34_01382 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) B34_01384 ENOG4108ZRV stage ii sporulation protein p B34_01387 ENOG4105TQK DNA polymerase iii, delta' subunit B34_01389 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 B34_01390 ENOG4108UK2 deaminase B34_01391 ENOG4105KQC Competence protein B34_01393 ENOG4108D32 Methyltransferase B34_01395 ENOG4108WF2 Metal Dependent Phosphohydrolase B34_01396 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) B34_01397 ENOG410812S Rna-binding protein B34_01398 ENOG4105E2X shikimate dehydrogenase B34_01399 ENOG4105CQW ribosome biogenesis GTPase YqeH B34_01400 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase B34_01403 ENOG4105Z7P Acetyltransferase (GNAT) family B34_01404 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) B34_01405 ENOG4108JB9 formate dehydrogenase B34_01408 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B34_01413 ENOG4108ZRV stage ii sporulation protein p B34_01415 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B34_01424 ENOG4105WH1 Two component transcriptional regulator luxr family B34_01425 ENOG4105BZU Histidine kinase B34_01426 ENOG4105XXY Thioredoxin B34_01427 ENOG41087NI Sulfite exporter TauE/SafE B34_01428 ENOG4105VFE sira family B34_01429 ENOG4107TPS domain protein B34_01430 ENOG4105VFE sira family B34_01431 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase B34_01432 ENOG4105XTG Pfam:DUF156 B34_01433 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) B34_01436 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) B34_01438 ENOG41080HJ 6-phospho 3-hexuloisomerase B34_01439 ENOG4108VA3 3-hexulose-6-phosphate synthase B34_01440 ENOG4105KVH Transcriptional regulator B34_01441 ENOG4105ECK Fatty Acid Desaturase B34_01442 ENOG4108ZGX Histidine kinase B34_01443 ENOG4108S01 response regulator B34_01444 ENOG4105CAY ferredoxin--nadp reductase B34_01445 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein B34_01446 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein B34_01447 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B34_01448 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B34_01450 ENOG4108JQ7 (ABC) transporter B34_01454 ENOG4108ZX5 transcriptional regulator B34_01455 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B34_01459 ENOG410635A Membrane B34_01461 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B34_01462 ENOG4108HKT sucrose-6-phosphate hydrolase B34_01463 ENOG4105F3R pts system mannose fructose sorbose family iid B34_01464 ENOG4105ETZ PTS System B34_01465 ENOG4108IQ3 PTS system B34_01466 ENOG4105YHU PTS system B34_01467 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family B34_01471 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B34_01472 ENOG4105CV8 reductase B34_01473 ENOG4105F27 Major Facilitator B34_01474 ENOG4105KVH Transcriptional regulator B34_01475 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) B34_01476 ENOG4105EXQ uroporphyrinogen iii synthase hem4 B34_01478 ENOG4108V5C ABC transporter B34_01479 ENOG4107RSM transcriptional regulator B34_01480 ENOG4105D94 Major Facilitator Superfamily B34_01482 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B34_01483 ENOG41082JN Transcriptional regulator B34_01484 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B34_01489 ENOG4105C28 cystathionine B34_01491 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B34_01492 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) B34_01495 ENOG4107XRG penicillin-binding protein B34_01496 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) B34_01498 ENOG4105CFP Peptidase U32 B34_01499 ENOG4105XYU peptidase (U32 family) B34_01500 ENOG4108VQJ O-methyltransferase B34_01501 ENOG4105HHA aminodeoxychorismate lyase B34_01502 ENOG4105VPH UPF0473 protein B34_01503 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) B34_01504 ENOG4105VBH UPF0297 protein B34_01505 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B34_01506 ENOG4105C02 permease B34_01507 ENOG41060CR B34_01509 ENOG4105C7H Helicase, RecD TraA family B34_01511 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) B34_01512 ENOG4105C3J Cysteine desulfurase B34_01514 ENOG4105D1H recombination factor protein RarA B34_01515 ENOG4105CUZ uba thif-type nad fad binding protein B34_01516 ENOG4105C9M aspartyl-trna synthetase B34_01517 ENOG4105CUT histidyl-tRNA synthetase B34_01519 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B34_01520 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) B34_01521 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B34_01522 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) B34_01523 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) B34_01524 ENOG41067VP Protein of unknown function (DUF1049) B34_01525 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) B34_01527 ENOG4105CKP Polysaccharide Biosynthesis Protein B34_01528 ENOG4108QG2 Membrane B34_01529 ENOG4105NAP B34_01530 ENOG4105VIE preprotein translocase, subunit YajC B34_01531 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) B34_01532 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) B34_01533 ENOG41061AI Protein of unknown function (DUF2905) B34_01534 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) B34_01535 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) B34_01539 ENOG41069DP small acid-soluble spore protein B34_01541 ENOG4105K7W phage-related replication protein B34_01544 ENOG4105CDY transcriptional regulatory protein B34_01546 ENOG4106678 morphogenetic protein associated with SpoVID B34_01547 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) B34_01548 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase B34_01549 ENOG4108IYU L-aspartate oxidase B34_01552 ENOG4105CQC Prephenate dehydratase B34_01553 ENOG41090I5 UPF0735 ACT domain-containing protein B34_01554 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control B34_01556 ENOG4105K46 50S ribosomal protein l27 B34_01557 ENOG4105X36 (ribosomal) protein B34_01558 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) B34_01562 ENOG41082BM Transcriptional regulator, arsr family B34_01563 ENOG4107QMS site-determining protein B34_01564 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) B34_01565 ENOG4105YHC Rod shape-determining protein MreD B34_01566 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) B34_01567 ENOG4105DFF Rod shape-determining protein mreb B34_01568 ENOG4105W5Q DNA repair protein (RadC B34_01569 ENOG4108Z03 MAF-like protein B34_01571 ENOG4106A3R peptidase B34_01572 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase B34_01573 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) B34_01575 ENOG4106AR7 Spore coat protein B34_01576 ENOG41068KH stage VI sporulation protein D B34_01577 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase B34_01578 ENOG4105D52 delta-aminolevulinic acid dehydratase B34_01580 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) B34_01582 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) B34_01584 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) B34_01585 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) B34_01586 ENOG4108IUQ atp-dependent protease B34_01587 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) B34_01588 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation B34_01590 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) B34_01591 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) B34_01592 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) B34_01593 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) B34_01594 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B34_01595 ENOG4108ZP8 Acetolactate synthase small subunit B34_01596 ENOG4105C7K acetolactate synthase B34_01597 ENOG4105CM2 brancheD-chain amino acid aminotransferase B34_01599 ENOG4105D82 Glutamate dehydrogenase B34_01602 ENOG4108MDF Phage Portal Protein B34_01603 ENOG4105IG6 Phage terminase, large subunit B34_01616 ENOG4105M59 Phosphodiesterase, mj0936 family B34_01617 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) B34_01618 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) B34_01619 ENOG4108XJQ germination protein B34_01620 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) B34_01621 ENOG41067TZ transcriptional regulator, MarR family B34_01622 ENOG4105PFC Transcriptional regulator B34_01623 ENOG4105EMU Dehydrogenase B34_01625 ENOG4105E33 succinate dehydrogenase B34_01627 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit B34_01629 ENOG4105CFH Aspartokinase B34_01630 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) B34_01631 ENOG4105K63 Thioredoxin B34_01632 ENOG4105C10 Electron transfer flavoprotein B34_01633 ENOG4105BZJ Electron transfer flavoprotein B34_01634 ENOG41060WC Enoyl-CoA hydratase B34_01635 ENOG4107Z3H Transcriptional regulator, TetR family B34_01636 ENOG4105CEY Amp-dependent synthetase and ligase B34_01638 ENOG4105C98 muts2 protein B34_01639 ENOG4105DCG PHP domain protein B34_01641 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) B34_01642 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B34_01646 ENOG4108IUZ ABC transporter B34_01649 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) B34_01650 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) B34_01651 ENOG4108RWN rrna methyltransferase B34_01652 ENOG41067MF small acid-soluble spore protein B34_01656 ENOG4105DRS transport system, permease B34_01659 ENOG4108MDK Dehydrogenase B34_01660 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase B34_01661 ENOG4105EF1 ribulokinase B34_01662 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) B34_01663 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) B34_01664 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase B34_01665 ENOG4105CN9 Peptidase m42 family protein B34_01667 ENOG410696E Membrane B34_01668 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) B34_01669 ENOG4105VJV 50s ribosomal protein L35 B34_01670 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) B34_01671 ENOG41067MG lrgb family B34_01673 ENOG4105DGI Alkaline phosphatase B34_01674 ENOG4105DY9 regulatoR B34_01675 ENOG4108HRK Histidine kinase B34_01677 ENOG4105U0R haloacid dehalogenase-like hydrolase B34_01678 ENOG4105C22 threonyL-tRNA synthetase B34_01679 ENOG4108TDW sporulation protein YtxC B34_01683 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) B34_01685 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B34_01686 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B34_01687 ENOG4108NR7 pectate lyase B34_01688 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) B34_01690 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) B34_01691 ENOG4105C2M dna polymerase I B34_01692 ENOG4105BZU Histidine kinase B34_01693 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B34_01694 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B34_01695 ENOG4108HMX isocitrate dehydrogenase (NADP) B34_01696 ENOG4105BZN citrate synthase B34_01697 ENOG4108VMM UPF0756 membrane protein B34_01698 ENOG4108REF Sporulation integral membrane protein ytvi B34_01699 ENOG4105FS0 cytoplasmic membrane protein B34_01700 ENOG4105CA9 Pyruvate kinase B34_01701 ENOG4105CTQ phosphohexokinase B34_01702 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) B34_01704 ENOG4105C6K Malic enzyme B34_01705 ENOG4105C0B DNA polymerase III (alpha subunit) B34_01706 ENOG4105VV2 B34_01708 ENOG4106EVM B34_01709 ENOG4105SFS phosphoesterase RecJ domain protein B34_01712 ENOG4105U3E Transcriptional regulator B34_01713 ENOG4105E8R UPF0173 metal-dependent hydrolase B34_01716 ENOG4105CH7 arginosuccinase B34_01717 ENOG4105CDH Citrulline--aspartate ligase B34_01718 ENOG4105EPU Molybdenum cofactor synthesis domain protein B34_01719 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) B34_01721 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) B34_01722 ENOG4105KBJ sporulation protein ytfj B34_01724 ENOG4105VK3 rdd domain containing protein B34_01725 ENOG4105D07 Signal peptide peptidase, SppA B34_01727 ENOG4105CW7 secretion protein, HlyD family B34_01731 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B34_01733 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) B34_01737 ENOG4105DQ6 Transposase B34_01740 ENOG4105U5Y Transcriptional regulator B34_01742 ENOG4105BZU Histidine kinase B34_01743 ENOG4105BZU Histidine kinase B34_01744 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) B34_01747 ENOG4105KAF membrAne B34_01748 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein B34_01749 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein B34_01752 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B34_01754 ENOG4105F1V Acetoin utilization protein B34_01755 ENOG4105W87 Cbs domain B34_01756 ENOG4105DGU Histone deacetylase B34_01757 ENOG4105ER2 Ompa motb domain protein B34_01758 ENOG4107R0U MotA TolQ exbB proton channel B34_01759 ENOG4105ETE Transcriptional regulator (LacI family B34_01760 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase B34_01766 ENOG4105DFU Cell wall formation (By similarity) B34_01768 ENOG4108VDD TRNA binding domain protein B34_01771 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ B34_01774 ENOG4105C6K Malic enzyme B34_01775 ENOG4105C8F Beta-lactamase domain protein B34_01776 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) B34_01778 ENOG4108V15 phosphotransferase enzyme family B34_01779 ENOG4108IUM Glycogen debranching enzyme B34_01780 ENOG4108IUM Glycogen debranching enzyme B34_01783 ENOG4107F58 2'-5' rna ligase B34_01784 ENOG4105C6T cysteine synthase B34_01786 ENOG4107QSE Dipeptidase B34_01787 ENOG4105C7N Xanthine uracil vitamin C permease B34_01788 ENOG4105YW5 deoR family transcriptional regulator B34_01791 ENOG4105CBX hi0933 family B34_01792 ENOG4105C94 Transporter B34_01794 ENOG41085GJ domain protein B34_01798 ENOG4105MU9 integral membrane protein B34_01799 ENOG4105DDC Oxidoreductase domain protein B34_01801 ENOG4105F5H Glycosyl Hydrolase Family 88 B34_01803 ENOG41075H3 AraC family transcriptional regulator B34_01805 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component B34_01807 ENOG4105NTD Inherit from COG: Hydrolase B34_01809 ENOG4107V2S Transcriptional regulator B34_01810 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase B34_01811 ENOG4105C8T Leucyl-tRNA synthetase B34_01813 ENOG410605W Major Facilitator B34_01814 ENOG4105D01 (LipO)protein B34_01815 ENOG4106UBQ B34_01816 ENOG4107R34 abc transporter permease protein B34_01817 ENOG4105C19 ABC transporter B34_01819 ENOG4105DVE abc transporter atp-binding protein B34_01820 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B34_01823 ENOG4105N5T Radical SAM Protein B34_01827 ENOG4105E8V Alpha Beta Hydrolase Fold protein B34_01828 ENOG4108Z0R Transferase B34_01829 ENOG4105YVM Phosphoesterase, PA-phosphatase related B34_01830 ENOG4105BZF Glycosyl transferase (Group 1 B34_01831 ENOG4105CAQ asparagine synthetase B34_01832 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP B34_01837 ENOG4105D2X ABC transporter substrate-binding protein B34_01839 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component B34_01843 ENOG4108RMU ferritin dps family protein B34_01846 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) B34_01847 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) B34_01848 ENOG4108V2W Carbonate dehydratase B34_01849 ENOG4105CKI cobalamin synthesis protein B34_01850 ENOG4105DSE periplasmic solute binding protein B34_01856 ENOG4105DTQ mandelate racemase muconate lactonizing B34_01857 ENOG4105CEY Amp-dependent synthetase and ligase B34_01858 ENOG4108IPT Naphthoate synthase B34_01859 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) B34_01860 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) B34_01861 ENOG4105E4F Isochorismate synthase B34_01862 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase B34_01865 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) B34_01867 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) B34_01868 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) B34_01893 ENOG4105CMD Transcriptional regulator, GntR family B34_01894 ENOG4105N67 Proton-coupled thiamine transporter YuaJ B34_01900 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) B34_01902 ENOG4105CZN Potassium uptake protein B34_01904 ENOG4106DF1 B34_01905 ENOG4108VNY MOSC domain protein B34_01906 ENOG4108JB8 alcohol dehydrogenase B34_01907 ENOG4105C26 Dehydrogenase B34_01908 ENOG4105TRT Transcriptional regulator B34_01910 ENOG4105JQZ Methyltransferase B34_01911 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B34_01912 ENOG4105F0F Oxalate decarboxylase B34_01920 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) B34_01926 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B34_01928 ENOG4105EE0 oxidoreductase B34_01929 ENOG4108Z0Z intracellular protease Pfpi family B34_01930 ENOG4105C8Q Methyl-accepting chemotaxis B34_01931 ENOG4105C8Q Methyl-accepting chemotaxis B34_01932 ENOG4105C8Q Methyl-accepting chemotaxis B34_01934 ENOG4105EA8 2-Nitropropane dioxygenase B34_01935 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme B34_01940 ENOG4105C37 (CBS) domain B34_01943 ENOG4107PBV potassium channel B34_01944 ENOG4107PBV potassium channel B34_01946 ENOG410900G Protein of unknown function (DUF421) B34_01948 ENOG4105KNA -acetyltransferase B34_01949 ENOG4107QYV phosphohexose isomerase B34_01950 ENOG4107QW4 alcohol dehydrogenase B34_01951 ENOG4105WG9 Conserved Protein B34_01953 ENOG4105CHM Aminotransferase B34_01954 ENOG4108ZB6 transcriptional regulator AsnC family B34_01955 ENOG4108MUZ hydrolase B34_01958 ENOG4105C87 Aminotransferase class I and II B34_01959 ENOG4105C87 Aminotransferase class I and II B34_01961 ENOG4105Y38 Kinase-associated protein B B34_01964 ENOG4105BZ4 penicillin-binding protein B34_01965 ENOG4105KIR Thiol-disulfide oxidoreductase dcc B34_01968 ENOG4108MRH transcriptional regulatory protein B34_01969 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B34_01970 ENOG4107ZTW SNARE associated Golgi B34_01971 ENOG4105DJ4 phosphatidylserine decarboxylase B34_01974 ENOG4105D65 subunit l B34_01975 ENOG4105HC0 Na H antiporter B34_01976 ENOG4108ZE9 Monovalent cation H antiporter subunit C B34_01977 ENOG4108JPZ Monovalent cation H antiporter subunit D B34_01978 ENOG4105SC1 monovalent cation H antiporter subunit E B34_01980 ENOG4105KJM monovalent cation h antiporter subunit g B34_01981 ENOG4105KA0 thioesterase Superfamily protein B34_01983 ENOG4105BZU Histidine kinase B34_01989 ENOG4105D58 Diguanylate phosphodiesterase B34_01990 ENOG4105DAP Nicotinate phosphoribosyltransferase B34_01995 ENOG4105C02 permease B34_01996 ENOG4108Z40 Transcriptional regulator B34_02000 ENOG410904N short-chain dehydrogenase reductase B34_02007 ENOG4105BZG amino acid carrier protein B34_02008 ENOG4108K8K Transcriptional regulator B34_02009 ENOG4105DCF alanine dehydrogenase B34_02014 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) B34_02016 ENOG41069ER domain protein B34_02018 ENOG4105CEP NADH dehydrogenase B34_02019 ENOG4105CAY ferredoxin--nadp reductase B34_02022 ENOG4108YM7 Gcn5-related n-acetyltransferase B34_02023 ENOG4108YX9 iron--sulfur cluster insertion protein erpA B34_02028 ENOG4108ZMX Domain of unknown function (DU1801) B34_02031 ENOG4105PY6 Phenolic acid decarboxylase B34_02034 ENOG41083MR nifu domain-containing protein B34_02035 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein B34_02036 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) B34_02037 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) B34_02038 ENOG4105D6E homoserine dehydrogenase B34_02039 ENOG4105C5I Dehydrogenase B34_02041 ENOG4108W5N phosphatidylglycerophosphatase a B34_02042 ENOG4105D4U had-superfamily hydrolase, subfamily iia B34_02044 ENOG4105MMD transcriptional regulator B34_02045 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) B34_02046 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) B34_02047 ENOG4105FAA peptidase M23 B34_02049 ENOG4105C8J )-transporter B34_02050 ENOG4108YTE sporulation protein YunB B34_02051 ENOG4105KZD Domain of unknown function (DUF1805) B34_02052 ENOG4107R8B 5'-nucleotidase B34_02054 ENOG4105I3N Conserved Protein B34_02055 ENOG4105IIP Membrane B34_02056 ENOG4105W1N transcriptional regulator B34_02058 ENOG4105C5R Aminotransferase B34_02060 ENOG4105G9B Transcriptional regulator B34_02064 ENOG4108I0Q anthranilate phosphoribosyltransferase B34_02065 ENOG4108I0Q anthranilate phosphoribosyltransferase B34_02066 ENOG4108K8S endonuclease I B34_02068 ENOG4107VFR oxidoreductase B34_02073 ENOG4105DIW FeS assembly protein SUFB B34_02074 ENOG4108UNV SUF system FeS assembly protein, NifU family B34_02075 ENOG4105C9B Cysteine desulfurase B34_02076 ENOG4105JRK feS assembly protein SufD B34_02077 ENOG4105C3K feS assembly ATPase SufC B34_02078 ENOG4105PGM cation diffusion facilitator family transporter B34_02080 ENOG4105D01 (LipO)protein B34_02081 ENOG4108UMI ABC transporter, permease B34_02082 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B34_02087 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) B34_02088 ENOG41080E8 Transcriptional regulator, Spx MgsR family B34_02089 ENOG4105C1G acyl-Coa dehydrogenase B34_02090 ENOG4105CHU acetyl-coa acetyltransferase B34_02097 ENOG4105E0A ABC, transporter B34_02098 ENOG4108IHU transport system permease protein B34_02099 ENOG4105DQ5 transport system permease protein B34_02100 ENOG4108MES Periplasmic binding protein B34_02103 ENOG4105DZ1 carboxypeptidase B34_02104 ENOG4105E1F short-chain dehydrogenase reductase B34_02105 ENOG4105HUF DNA protection during starvation protein B34_02106 ENOG4105C0H protease B34_02108 ENOG4105F3H Histidine kinase B34_02110 ENOG41067SE Tetr family transcriptional regulator B34_02111 ENOG4105C9Q fumarate hydratase class II B34_02117 ENOG4105WH1 Two component transcriptional regulator luxr family B34_02118 ENOG4105ENE Histidine kinase B34_02121 ENOG41087YS Phage shock protein A B34_02124 ENOG4108WBT adenosyltransferase B34_02125 ENOG4105EMU Dehydrogenase B34_02126 ENOG4105CHR reductase B34_02127 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) B34_02128 ENOG4105C0A alcohol dehydrogenase B34_02129 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B34_02130 ENOG4105E0A ABC, transporter B34_02131 ENOG4105EHG Permease protein B34_02132 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) B34_02133 ENOG4105DRR Transcriptional regulator, GntR family B34_02134 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B34_02135 ENOG4108RPX mosc domain containing protein B34_02136 ENOG4105DND Transcriptional regulator B34_02138 ENOG4105CTX dehydratase B34_02139 ENOG4107QZW Altronate oxidoreductase B34_02140 ENOG4107KJX Transcriptional regulator B34_02141 ENOG4105CT4 transporter B34_02142 ENOG4105D2H Uronic isomerase B34_02144 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B34_02145 ENOG4105E0A ABC, transporter B34_02146 ENOG4105EHG Permease protein B34_02147 ENOG4105DQ5 transport system permease protein B34_02148 ENOG4105D5Q Arginine ornithine antiporter B34_02149 ENOG4107K5X Membrane-bound metal-dependent hydrolase B34_02150 ENOG4107QZ2 Sulfatase B34_02153 ENOG4105EVU fructokinase B34_02154 ENOG4107EPV Aminotransferase class V B34_02156 ENOG4105EEM helicase B34_02157 ENOG4105EN6 Membrane B34_02158 ENOG4105RHY Pfam:UPF0157 B34_02160 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B34_02162 ENOG4107ZQN disulfide bond B34_02163 ENOG4105C59 p-type ATPase B34_02164 ENOG4108JE9 extracellular solute-binding protein family 1 B34_02165 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component B34_02166 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component B34_02167 ENOG4105CJQ hydrolase, family 31 B34_02169 ENOG4105DIK (ABC) transporter B34_02170 ENOG4105CC5 ABC transporter B34_02171 ENOG4105DSE periplasmic solute binding protein B34_02174 ENOG4105HX0 Transcriptional regulator B34_02175 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) B34_02176 ENOG4105DM4 PTS System B34_02180 ENOG4105C59 p-type ATPase B34_02181 ENOG410681U heavy metal transport detoxification protein B34_02182 ENOG4105VPX protein, conserved in bacteria B34_02183 ENOG4107RKG DJ-1/PfpI family B34_02184 ENOG4105E98 transcriptional regulator DeoR family B34_02185 ENOG4105DET Rhamnulokinase B34_02186 ENOG4105C9F isomerase B34_02189 ENOG4105F27 Major Facilitator B34_02191 ENOG410625E B34_02192 ENOG4106A3M Cytochrome p-450 B34_02197 ENOG4105D9R oxidoreductase B34_02200 ENOG4105C72 UPF0176 protein B34_02202 ENOG4106DF4 Sigma-70, region 4 B34_02204 ENOG4105F0F Oxalate decarboxylase B34_02219 ENOG4107EV6 Inherit from COG: YD repeat protein B34_02226 ENOG41068G1 B34_02228 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj B34_02230 ENOG4108FKH Transglycosylase SLT domain B34_02239 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B34_02242 ENOG4105CAR Terminase, large subunit B34_02276 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) B34_02277 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) B34_02279 ENOG4105XZU Preprotein translocase, subunit SecG B34_02284 ENOG4105R40 Glycine betaine carnitine choline B34_02285 ENOG4108HQR Glycine betaine B34_02286 ENOG4105E90 ABC transporter B34_02287 ENOG4108IJ8 ABC transporter B34_02288 ENOG4107HG4 Transcriptional regulator B34_02289 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein B34_02290 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein B34_02292 ENOG4105T65 Membrane-associated protein B34_02294 ENOG4108MES Periplasmic binding protein B34_02296 ENOG4108V4B ThiJ pfpI B34_02297 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) B34_02298 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) B34_02299 ENOG4105CP7 Triose-phosphate isomerase B34_02300 ENOG4105BZA Phosphoglycerate kinase B34_02301 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B34_02303 ENOG4105DEN Luciferase family B34_02306 ENOG4105CIG ABC transporter B34_02310 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B34_02311 ENOG4105JXH GntR family transcriptional regulator B34_02312 ENOG4105DAA L-lactate B34_02313 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B34_02315 ENOG4108ZPC Polysaccharide pyruvyl transferase B34_02316 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B34_02317 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family B34_02318 ENOG4105D3Q Sugar transferase B34_02320 ENOG4105K64 Glycosyl transferase, family 2 B34_02322 ENOG4107QRS glycosyltransferase group 2 family protein B34_02323 ENOG41068W6 Capsular polysaccharide biosynthesis protein B34_02324 ENOG4108KMV Glycosyl transferase (Group 1 B34_02325 ENOG4105K64 Glycosyl transferase, family 2 B34_02326 ENOG4108PQP glycosyl transferase group 1 B34_02328 ENOG4108QV3 biosynthesis protein B34_02329 ENOG4105HTX biosynthesis protein B34_02331 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B34_02333 ENOG4108I5G Major Facilitator superfamily B34_02335 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) B34_02336 ENOG4107S2N Type III effector Hrp-dependent B34_02338 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B34_02341 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B34_02342 ENOG4105EDQ levansucrase EC 2.4.1.10 B34_02343 ENOG4108HKT sucrose-6-phosphate hydrolase B34_02346 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B34_02347 ENOG4108URH decarboxylase B34_02348 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain B34_02349 ENOG4107TVP HD domain protein B34_02350 ENOG4105CHH sulfate transporter B34_02351 ENOG4108V2W Carbonate dehydratase B34_02352 ENOG4105C5I Dehydrogenase B34_02353 ENOG4108SQ9 flavin reductase domain protein, FMN-binding B34_02354 ENOG4108ZHR arsR family transcriptional regulator B34_02357 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B34_02358 ENOG4105KRI phosphocarrier protein (HPr B34_02359 ENOG4105CIE May be required for sporulation (By similarity) B34_02360 ENOG4105CHW UPF0052 protein B34_02361 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) B34_02362 ENOG4108Z4K mutator MutT protein B34_02363 ENOG4105C3M thioredoxin reductase B34_02366 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase B34_02367 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) B34_02368 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase B34_02369 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) B34_02370 ENOG4105ECC imidazole-glycerol-phosphate dehydratase B34_02371 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) B34_02372 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) B34_02373 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) B34_02375 ENOG4108E16 pectate lyase B34_02376 ENOG4108S4C acetyltransferase B34_02377 ENOG4107XGZ Hydrolase B34_02378 ENOG4105HKU nucleoside recognition domain-containing protein B34_02380 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) B34_02381 ENOG410834F Transcriptional regulator B34_02382 ENOG4105C0R drug resistance transporter emrb qaca subfamily B34_02383 ENOG41088CQ domain protein B34_02384 ENOG41086DT Membrane protein of unknown function B34_02385 ENOG41067S9 phage shock protein C, PspC B34_02386 ENOG4108PY7 B34_02390 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B34_02391 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) B34_02396 ENOG4105CN1 protease B34_02397 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) B34_02399 ENOG4105CRP Part of the ABC transporter FtsEX involved in B34_02400 ENOG4105CAK Cell division ATP-binding protein ftsE B34_02403 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) B34_02404 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving B34_02405 ENOG4105MS2 ribosomal subunit Interface protein B34_02408 ENOG4105MQ3 flagellar protein FliS B34_02409 ENOG4107RT6 flagellar hook-associated B34_02410 ENOG41083S7 flagellar protein FlaG B34_02411 ENOG4105I03 Flagellin B34_02412 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) B34_02413 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) B34_02414 ENOG4105MKD B34_02415 ENOG4105DTJ flagellar hook-associated protein B34_02416 ENOG4105E1Q flagellar hook-associated protein B34_02419 ENOG4105RU3 B34_02423 ENOG4105WH1 Two component transcriptional regulator luxr family B34_02424 ENOG4105BZU Histidine kinase B34_02425 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein B34_02426 ENOG4108KGH TRANSCRIPTIONal B34_02428 ENOG4105ESV Glycosyl transferase, family 4 B34_02429 ENOG4107EF8 Glycosyl transferase (Group 1 B34_02432 ENOG4105QZI O-Antigen Polymerase B34_02433 ENOG4105C1B dTDP-glucose 4-6-dehydratase B34_02434 ENOG4105C6Y Udp-glucose 6-dehydrogenase B34_02435 ENOG4107RA4 Glycosyl transferase (Group 1 B34_02436 ENOG4105PSV Polysaccharide Biosynthesis Protein B34_02437 ENOG4105D3Q Sugar transferase B34_02438 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B34_02439 ENOG4105JFG SpoIID LytB domain protein B34_02441 ENOG4108KGH TRANSCRIPTIONal B34_02442 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase B34_02443 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B34_02444 ENOG4105EY8 ABC transporter B34_02446 ENOG4105CG5 Glycosyl transferase (Group 1 B34_02447 ENOG4105CG5 Glycosyl transferase (Group 1 B34_02448 ENOG4107SJB teichoic acid biosynthesis B34_02452 ENOG4107SJB teichoic acid biosynthesis B34_02453 ENOG4107SJB teichoic acid biosynthesis B34_02454 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase B34_02456 ENOG4107RZX Teichoic acid biosynthesis protein B34_02458 ENOG4105DG6 mannose-6-phosphate isomerase B34_02460 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase B34_02461 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) B34_02462 ENOG4108UHU Aldolase B34_02463 ENOG4105D7K pfkb domain protein B34_02464 ENOG4108M60 Transcriptional regulator B34_02466 ENOG4105CHR reductase B34_02467 ENOG4105E2A Dehydrogenase B34_02469 ENOG4105C54 Major Facilitator superfamily B34_02470 ENOG4108KGH TRANSCRIPTIONal B34_02471 ENOG4105J7I hydrolase B34_02472 ENOG4105K4H Nlp p60 protein B34_02474 ENOG4105PNM synthesis protein B34_02476 ENOG4105N98 Capsule biosynthesis protein capB B34_02477 ENOG4105ETE Transcriptional regulator (LacI family B34_02478 ENOG4108RVA ribokinase B34_02479 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) B34_02480 ENOG4105C2J ABC transporter B34_02481 ENOG4105CNN ABC, transporter B34_02482 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator B34_02483 ENOG4107FQX Alpha-acetolactate decarboxylase B34_02485 ENOG4107RSM transcriptional regulator B34_02486 ENOG4105DQ6 Transposase B34_02488 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) B34_02490 ENOG4105CAH Chromate B34_02491 ENOG4105FGV Chromate B34_02492 ENOG4108RB3 Capsular polysaccharide biosynthesis protein B34_02493 ENOG4105HTX biosynthesis protein B34_02495 ENOG4105KBK Zinc finger, swim domain protein B34_02496 ENOG4105C0D helicase B34_02498 ENOG410667J hydrolase B34_02499 ENOG4105E98 transcriptional regulator DeoR family B34_02501 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase B34_02502 ENOG4105VI0 Pts system, glucitol sorbitol-specific B34_02503 ENOG4105DZY Pts system, glucitol sorbitol-specific B34_02504 ENOG410787A Pts system, glucitol sorbitol-specific B34_02506 ENOG4105DKT Transcriptional regulator B34_02507 ENOG4105Z8H single-stranded DNA-binding protein B34_02511 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) B34_02512 ENOG4105CGA flagellar basal-body rod protein FlgG B34_02514 ENOG4105DFF Rod shape-determining protein mreb B34_02515 ENOG4105MT0 Sporulation transcriptional regulator spoiiid B34_02516 ENOG4107MII Sugar-specific transcriptional regulator TrmB B34_02517 ENOG4105CZM Major Facilitator B34_02518 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase B34_02519 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase B34_02521 ENOG4108NA0 Uncharacterized conserved protein (COG2071) B34_02522 ENOG41080XP Cbs domain B34_02524 ENOG4105C37 (CBS) domain B34_02525 ENOG4105BZU Histidine kinase B34_02529 ENOG4105FRN stage II sporulation protein B34_02530 ENOG4107TCE N-acetyltransferase B34_02532 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B34_02533 ENOG4105C0R drug resistance transporter emrb qaca subfamily B34_02534 ENOG4105WQT MbtH domain protein B34_02535 ENOG4105CEY Amp-dependent synthetase and ligase B34_02536 ENOG4105WQI isochorismatase B34_02537 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase B34_02538 ENOG4105E4F Isochorismate synthase B34_02539 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase B34_02540 ENOG4105NIV Esterase B34_02544 ENOG410874W AraC family transcriptional regulator B34_02546 ENOG4108RYK Nad-dependent epimerase dehydratase B34_02547 ENOG4108Z40 Transcriptional regulator B34_02550 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B34_02551 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B34_02552 ENOG4105FCD Major Facilitator B34_02553 ENOG4108HIZ formate dehydrogenase alpha subunit B34_02554 ENOG4108TF4 von Willebrand factor, type A B34_02557 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B34_02559 ENOG4106778 Protein of unknown function (DUF1146) B34_02560 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) B34_02561 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) B34_02562 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) B34_02563 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) B34_02564 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) B34_02567 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) B34_02569 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) B34_02570 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) B34_02571 ENOG4108UIC UPF0340 protein B34_02572 ENOG4108YZG isomerase B34_02573 ENOG4107WAU Protein tyrosine phosphatase B34_02574 ENOG410815N Probably functions as a manganese efflux pump (By similarity) B34_02575 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B34_02577 ENOG4108ZXQ stage ii sporulation protein r B34_02580 ENOG4105TRI Hydrolase B34_02583 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) B34_02584 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) B34_02585 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase B34_02587 ENOG4107TT2 Auxin Efflux Carrier B34_02588 ENOG4105C6K Malic enzyme B34_02589 ENOG4107104 thymidine kinase B34_02590 ENOG41082DI 50s ribosomal protein l31 B34_02591 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) B34_02592 ENOG4105CBT Fructose-1,6-bisphosphatase B34_02593 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B34_02594 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway B34_02595 ENOG4105D2N Aldolase B34_02596 ENOG410812K response regulator receiver protein B34_02600 ENOG4105DQ6 Transposase B34_02601 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) B34_02603 ENOG4105C1G acyl-Coa dehydrogenase B34_02604 ENOG4105C1G acyl-Coa dehydrogenase B34_02605 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B34_02607 ENOG4105DF6 Fe-S oxidoreductase B34_02610 ENOG4105C75 arginyL-tRNA synthetase B34_02611 ENOG410684U Domain of unknown function (DUF1934) B34_02612 ENOG4105CYW agmatinase B34_02613 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) B34_02616 ENOG4105BZ4 penicillin-binding protein B34_02617 ENOG4108XFG YwhD family B34_02618 ENOG4108Z4T Peptidase M50 B34_02619 ENOG41069HH 4-oxalocrotonate tautomerase B34_02622 ENOG4105DCI Phosphohydrolase B34_02624 ENOG4108VCI transcription factor, rsfa family B34_02626 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) B34_02628 ENOG4105D2S major facilitator superfamily B34_02633 ENOG4108FUF Transcriptional regulator, IclR family B34_02635 ENOG4108IJ2 phosphate acetyltransferase B34_02636 ENOG4107JTW chlorite dismutase B34_02638 ENOG4105CZN Potassium uptake protein B34_02642 ENOG4105CJ1 ABC, transporter B34_02648 ENOG4105C26 Dehydrogenase B34_02649 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) B34_02650 ENOG4108RJ9 Glycosyl transferase, family 2 B34_02651 ENOG4105DWF phosphomethylpyrimidine kinase B34_02654 ENOG4105C5Y PTS System B34_02658 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin B34_02660 ENOG4105DEN Luciferase family B34_02662 ENOG4108DBC nitroreductase B34_02666 ENOG4105DWD nucleoside recognition domain protein B34_02678 ENOG41060D1 Quinol oxidase B34_02680 ENOG4105BZ9 Cytochrome C oxidase, subunit I B34_02681 ENOG4105E2S oxidase) subunit II B34_02682 ENOG4105CMR udp-glucose 4-epimerase B34_02686 ENOG4108WS4 fmn reductase B34_02689 ENOG4105CMG Carbohydrate kinase B34_02690 ENOG4105C93 Xylose Isomerase B34_02692 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) B34_02693 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase B34_02694 ENOG4105CMU LysR family (Transcriptional regulator B34_02698 ENOG41067MG lrgb family B34_02700 ENOG4105CK7 Sodium proline symporter B34_02701 ENOG4105DR4 Methyltransferase B34_02703 ENOG4105C5I Dehydrogenase B34_02704 ENOG4105X1N Glycosyl transferase family 8 B34_02707 ENOG4105ENE Histidine kinase B34_02708 ENOG4108VB1 regulatoR B34_02709 ENOG4105EYF MMPL domain protein B34_02711 ENOG4105DJB Major Facilitator Superfamily B34_02712 ENOG4105CXK mandelate racemase muconate lactonizing B34_02713 ENOG4108UHU Aldolase B34_02714 ENOG4105D7K pfkb domain protein B34_02716 ENOG4105IIU Aminopeptidase B34_02717 ENOG41080V3 Major Facilitator superfamily B34_02722 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) B34_02723 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein B34_02724 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) B34_02725 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B34_02726 ENOG4105CM2 brancheD-chain amino acid aminotransferase B34_02728 ENOG4105F8D glycoside hydrolase family 4 B34_02729 ENOG4105VCP PTS System B34_02730 ENOG4105CK1 PTS System B34_02731 ENOG4105VZJ PTS System B34_02732 ENOG4105EMD TRANSCRIPTIONal B34_02734 ENOG4108VX5 3-methyladenine DNA glycosylase B34_02737 ENOG4105DXD 2-methylcitrate dehydratase B34_02738 ENOG4105CR4 methylisocitrate lyase B34_02741 ENOG4105BZ1 (ABC) transporter B34_02742 ENOG4107TDE lipolytic protein G-D-S-L family B34_02745 ENOG4105C2C drug resistance transporter, Bcr CflA B34_02747 ENOG4105DA5 (ABC) transporter B34_02748 ENOG41069JR B34_02753 ENOG4105CH6 catalase B34_02755 ENOG4105G5W regulator Fur family B34_02756 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B34_02757 ENOG4108TU7 Inherit from COG: (ABC) transporter B34_02758 ENOG4105CJ1 ABC, transporter B34_02761 ENOG4105CJ1 ABC, transporter B34_02771 ENOG4108J20 pectate lyase B34_02772 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) B34_02773 ENOG4108JJ8 (ABC) transporter B34_02774 ENOG4108JJ9 ABC, transporter B34_02775 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B34_02776 ENOG4105C4M (Ubiquinol oxidase) subunit I B34_02777 ENOG4108QTI )-transporter B34_02780 ENOG4105DFD Na H antiporter B34_02781 ENOG4108IJ0 Aspartate ammonia-lyase B34_02782 ENOG4105HDK L-asparaginase B34_02783 ENOG4108IMY Transcriptional regulator B34_02784 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) B34_02792 ENOG4107BJW polysaccharide deacetylase B34_02793 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B34_02794 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B34_02795 ENOG4107QZ7 Cellulose synthase catalytic subunit B34_02796 ENOG4105D2K citrate carrier protein B34_02797 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B34_02798 ENOG4105X3H Excalibur domain protein B34_02800 ENOG4105E0M Sulfatase B34_02802 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) B34_02804 ENOG4105CEU Arginine dihydrolase B34_02805 ENOG4105DBV ornithine carbamoyltransferase B34_02807 ENOG4105C5B carbamate kinase B34_02809 ENOG4105CS2 ec 3.2.1.21 B34_02810 ENOG4105CK1 PTS System B34_02812 ENOG4105JVQ RNA Polymerase B34_02817 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) B34_02818 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B34_02819 ENOG4107R3K hydrolase B34_02820 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) B34_02821 ENOG4105DRS transport system, permease B34_02822 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component B34_02824 ENOG4105ETE Transcriptional regulator (LacI family B34_02829 ENOG4105EDW glycosyl transferase, family 39 B34_02830 ENOG4105CKK Glycosyl transferase, family 2 B34_02831 ENOG4105CMR udp-glucose 4-epimerase B34_02834 ENOG4105CH6 catalase B34_02836 ENOG4105CS2 ec 3.2.1.21 B34_02837 ENOG4105C5Y PTS System B34_02838 ENOG4105CID antiterminator B34_02839 ENOG4108W7F transporter, permease B34_02840 ENOG4108JJB ABC transporter B34_02841 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein B34_02842 ENOG4105ETU transcriptional activator (TenA B34_02845 ENOG4107QP3 malate synthase g B34_02847 ENOG4105EDW glycosyl transferase, family 39 B34_02849 ENOG4105C19 ABC transporter B34_02850 ENOG4105EWM Histidine kinase B34_02852 ENOG4105CS2 ec 3.2.1.21 B34_02853 ENOG4105C5Y PTS System B34_02855 ENOG4107QHE Choloylglycine hydrolase B34_02858 ENOG4106Z5D Glycoside Hydrolase Family 43 B34_02859 ENOG4105C1J atp-dependent rna helicase B34_02865 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) B34_02866 ENOG4105D9N nucleoside B34_02867 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) B34_02868 ENOG4107RHR regulatoR B34_02872 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) B34_02873 ENOG4107R8N Glycosyl transferase, family 2 B34_02874 ENOG4107R8N Glycosyl transferase, family 2 B34_02876 ENOG4105JKW Valine--pyruvate aminotransferase B34_02881 ENOG4105D2N Aldolase B34_02882 ENOG4107TRN Xylose isomerase domain protein TIM barrel B34_02883 ENOG4105F0H myo-inositol catabolism protein B34_02884 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) B34_02886 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) B34_02887 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) B34_02888 ENOG4105D7K pfkb domain protein B34_02889 ENOG4105DH8 myo-inositol catabolism B34_02890 ENOG4105C26 Dehydrogenase B34_02892 ENOG4105CPC Aldo Keto reductase B34_02893 ENOG4107VXM glycerophosphoryl diester phosphodiesterase B34_02894 ENOG4105CXY transporter B34_02895 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) B34_02896 ENOG4105C5H ABC transporter B34_02897 ENOG410667J hydrolase B34_02899 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) B34_02901 ENOG4108V5C ABC transporter B34_02906 ENOG4105H93 Acyltransferase family B34_02912 ENOG4105EC8 Methyl-accepting chemotaxis B34_02913 ENOG4105BZG amino acid carrier protein B34_02914 ENOG4105DCF alanine dehydrogenase B34_02917 ENOG4105EG2 ABC transporter, permease B34_02919 ENOG4107FKK extracellular solute-binding protein family 1 B34_02921 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) B34_02922 ENOG4105CMR udp-glucose 4-epimerase B34_02923 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase B34_02924 ENOG4105E2R ROK family B34_02926 ENOG4105CMG Carbohydrate kinase B34_02929 ENOG4108EKI Dehydrogenase B34_02930 ENOG4105D3R alkyl hydroperoxide reductase B34_02931 ENOG4108JU3 Alkyl hydroperoxide reductase B34_02936 ENOG4108M15 ABC transporter B34_02937 ENOG4105KCT ABC transporter B34_02938 ENOG4105BZU Histidine kinase B34_02939 ENOG4105BZU Histidine kinase B34_02946 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) B34_02949 ENOG4105WQG acetyltransferase B34_02952 ENOG4105C0H protease B34_02953 ENOG4105Q2H domain protein B34_02956 ENOG4105BZU Histidine kinase B34_02957 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B34_02963 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis B34_02965 ENOG4105CDU Replicative dna helicase B34_02969 ENOG4105DJ2 Major Facilitator Superfamily B34_02970 ENOG4105CE4 GlcNAc 6-P deacetylase B34_02971 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) B34_02972 ENOG4105FDP GntR family transcriptional regulator B34_02973 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate B34_02975 ENOG4105K9Q Binds to the 23S rRNA (By similarity) B34_02976 ENOG4105BZR domain protein B34_02977 ENOG4108XMW Membrane B34_02979 ENOG4107YZX Universal stress protein B34_02980 ENOG4105CHH sulfate transporter B34_02982 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) B34_02983 ENOG4108UUM single-stranded DNA-binding protein B34_02984 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) B34_02985 ENOG4105C3G gtp-binding protein B34_02986 ENOG4105VDK protein, conserved in bacteria B34_02988 ENOG4108ZDA Sporulation protein YyaC B34_02989 ENOG4105FA0 parb-like partition protein B34_02990 ENOG4107QJE Chromosome Partitioning Protein B34_02991 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) B34_02993 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) B34_02995 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) B34_02996 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) B34_02999 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) B34_03000 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) B34_03001 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B34_03002 ENOG410848D S4 domain protein YaaA B34_03003 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) B34_03004 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B34_03005 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B34_03012 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) B34_03014 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) B34_03015 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) B34_03016 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) B34_03017 ENOG4105BZW Glycerate kinase B34_03018 ENOG4107QQ0 gntp family B34_03019 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR B34_03022 ENOG4105ZMH deoxynucleoside kinase B34_03024 ENOG4105VRS hydrolase family 18 B34_03025 ENOG4105GTG Isochorismatase B34_03026 ENOG4108Z6B deaminase B34_03027 ENOG4105C6E dna polymerase iii B34_03028 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) B34_03029 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) B34_03031 ENOG41067KS pro-sigma K processing B34_03039 ENOG4105CDW Resistance protein B34_03040 ENOG4105CXN decarboxylase B34_03041 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) B34_03042 ENOG4105X0R protein from nitrogen regulatory protein P-II B34_03043 ENOG4105XVJ Protein of unknown function (DUF327) B34_03044 ENOG4105FA2 dna polymerase iii B34_03045 ENOG4105MA4 psp1 domain protein B34_03046 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) B34_03047 ENOG41060K3 Methyltransferase B34_03048 ENOG4105VC4 domain protein B34_03049 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) B34_03050 ENOG4105KRN Transcriptional regulator, abrb family B34_03051 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) B34_03052 ENOG4105F8V Hydrolase, tatD family B34_03053 ENOG41069ER domain protein B34_03055 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) B34_03056 ENOG4105XFA sporulation peptidase YabG B34_03057 ENOG4105W42 Veg protein B34_03058 ENOG4105XEW small acid-soluble spore protein B34_03060 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) B34_03061 ENOG4105DFT pur operon repressor B34_03062 ENOG4105KME endoribonuclease L-psp B34_03063 ENOG4105K4W Could be involved in septation (By similarity) B34_03064 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) B34_03065 ENOG4105C5T Phosphoribosyl pyrophosphate synthase B34_03066 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) B34_03069 ENOG4108JA2 transcriptioN-repair coupling factor B34_03070 ENOG4108M14 stage v sporulation protein t B34_03072 ENOG4108IY2 MazG family B34_03073 ENOG41082I2 s4 domain protein B34_03074 ENOG4105VYY sporulation protein yabp B34_03077 ENOG41060GV RNA binding s1 domain protein B34_03083 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) B34_03084 ENOG4108UGV hypoxanthine phosphoribosyltransferase B34_03085 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) B34_03086 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) B34_03087 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) B34_03088 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase B34_03089 ENOG4105C6T cysteine synthase B34_03090 ENOG4105CRQ synthase (Component I) B34_03091 ENOG4105DDQ anthranilate synthase B34_03092 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 B34_03093 ENOG4105EEI dihydropteroate synthase B34_03094 ENOG4105KRF dihydroneopterin aldolase B34_03095 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase B34_03097 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) B34_03098 ENOG4105CRK lysyL-tRNA synthetase B34_03115 ENOG4108Z0C Uvrb UvrC protein B34_03116 ENOG41066A3 ATP guanido phosphotransferase B34_03118 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) B34_03119 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) B34_03120 ENOG4105CTP PilT protein domain protein B34_03121 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) B34_03122 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) B34_03123 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) B34_03124 ENOG4105D7W serine acetyltransferase B34_03125 ENOG4105C8N cysteinyl-tRNA synthetase B34_03126 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) B34_03127 ENOG4105C2N RNA methyltransferase TrmH family group 3 B34_03128 ENOG4105M0M Tetracycline resistance protein B34_03129 ENOG4105QIV RNA polymerase B34_03130 ENOG410683Z Preprotein translocase SecE subunit B34_03131 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) B34_03132 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) B34_03133 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) B34_03134 ENOG4108VZM 50s ribosomal protein L10 B34_03135 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) B34_03136 ENOG4107Y49 methyltransferase B34_03137 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B34_03138 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B34_03139 ENOG4105XPM ribosomal protein B34_03140 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) B34_03141 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) B34_03142 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) B34_03143 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) B34_03144 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) B34_03145 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) B34_03146 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) B34_03147 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) B34_03148 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity B34_03149 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) B34_03150 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) B34_03151 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) B34_03152 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) B34_03153 ENOG41082SA 50s ribosomal protein l29 B34_03154 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal B34_03155 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) B34_03156 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) B34_03157 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits B34_03158 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) B34_03159 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) B34_03160 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) B34_03161 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) B34_03162 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) B34_03163 ENOG4105VPB 50S ribosomal protein L30 B34_03164 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) B34_03165 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B34_03166 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) B34_03167 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B34_03169 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) B34_03171 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits B34_03172 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) B34_03173 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B34_03174 ENOG4108ZT0 50S ribosomal protein l17 B34_03175 ENOG4108JJB ABC transporter B34_03176 ENOG4108JJB ABC transporter B34_03177 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) B34_03178 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B34_03179 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) B34_03180 ENOG4108UJD 30S ribosomal protein S9 B34_03191 ENOG4108JJA ABC, transporter B34_03196 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism B34_03202 ENOG4105D1F ATP-binding protein B34_03205 ENOG4108NMV polysaccharide deacetylase B34_03212 ENOG4108A04 Beta-lactamase B34_03216 ENOG4105JAB phenazine biosynthesis protein, phzf family B34_03217 ENOG4105EHZ conserved protein UCP016719 B34_03218 ENOG4105D17 glycoside hydrolase, family 3 domain protein B34_03222 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate B34_03223 ENOG4105EWC Purine nucleoside phosphorylase B34_03230 ENOG4105EMN RNA polymerase sigma factor B34_03232 ENOG4105C8B TIGR00159 family B34_03233 ENOG4107U5W ybbr family B34_03234 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) B34_03235 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) B34_03239 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B34_03240 ENOG4105WAB arsR family transcriptional regulator B34_03241 ENOG4108RWP Major Facilitator Superfamily protein B34_03243 ENOG4105BZ1 (ABC) transporter B34_03244 ENOG4107ZXU DSBA oxidoreductase B34_03247 ENOG41075D4 Aminoglycoside 6-adenylyltransferase B34_03253 ENOG4108MRH transcriptional regulatory protein B34_03255 ENOG4105DUM transcriptional regulator, lysR family B34_03257 ENOG4105E5W Transporter B34_03258 ENOG4106DDH Sporulation-specific SASP protein B34_03261 ENOG4105C7Z Conserved Protein B34_03262 ENOG4105DXI Major Facilitator superfamily B34_03267 ENOG4107I77 yiaA/B two helix domain B34_03272 ENOG410631K Membrane B34_03273 ENOG4106AXJ AraC family transcriptional regulator B34_03277 ENOG4107SCQ Iron-containing alcohol dehydrogenase B34_03278 ENOG4105C8Q Methyl-accepting chemotaxis B34_03279 ENOG4105DFW ABC transporter B34_03282 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid B34_03284 ENOG4108IQI permease B34_03285 ENOG4108J5H Homocysteine s-methyltransferase B34_03287 ENOG4105CI1 PTS System B34_03288 ENOG4107TXC Transcriptional regulator B34_03289 ENOG4108QY0 Membrane B34_03293 ENOG4105CSV Glutaminase B34_03296 ENOG4105KNA -acetyltransferase B34_03298 ENOG4105NA0 Transcriptional regulator B34_03300 ENOG4105DGI Alkaline phosphatase B34_03301 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) B34_03302 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B34_03303 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase B34_03304 ENOG4105C26 Dehydrogenase B34_03305 ENOG4105DJB Major Facilitator Superfamily B34_03306 ENOG4105EQX glucarate dehydratase B34_03307 ENOG41073TP transcriptional regulator B34_03308 ENOG4105CTX dehydratase B34_03309 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B34_03314 ENOG4108R1P B34_03315 ENOG4106K80 B34_03317 ENOG41067TZ transcriptional regulator, MarR family B34_03322 ENOG4107TXC Transcriptional regulator B34_03327 ENOG4106UX7 integral membrane protein B34_03329 ENOG41060AI SEC-C motif B34_03330 ENOG4105DA5 (ABC) transporter B34_03335 ENOG4108KSA LysR family transcriptional regulator B34_03336 ENOG4105MDS 4-oxalocrotonate tautomerase B34_03342 ENOG4108W0I acetyltransferase B34_03344 ENOG4105DPN Oligoendopeptidase f B34_03345 ENOG4107BMA Transglycosylase associated protein B34_03347 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B34_03348 ENOG4105CQB FAD linked oxidase domain protein B34_03349 ENOG4105VZJ PTS System B34_03350 ENOG4105VCP PTS System B34_03351 ENOG4105CK1 PTS System B34_03352 ENOG4105F8D glycoside hydrolase family 4 B34_03353 ENOG4108X79 transcriptional regulator B34_03354 ENOG410901P UPF0249 protein B34_03358 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases B34_03359 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B34_03362 ENOG4105KHC sulfurtransferase B34_03364 ENOG4105DEN Luciferase family B34_03365 ENOG4105Z8B NlpC/P60 family B34_03368 ENOG4105CIG ABC transporter B34_03369 ENOG4108RZE Tetr family transcriptional regulator B34_03373 ENOG4108N0M stress protein B34_03374 ENOG4106FN3 tellurium resistance protein B34_03375 ENOG4106FN3 tellurium resistance protein B34_03376 ENOG4107TS3 membrane protein, TerC B34_03379 ENOG4108TTB tellurium resistance protein B34_03381 ENOG4107QIV Cytochrome c biogenesis protein B34_03383 ENOG4107SWG transcriptional regulator MERR family B34_03390 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) B34_03391 ENOG410756H nucleotidyltransferase B34_03393 ENOG4105C26 Dehydrogenase B34_03394 ENOG4105CK7 Sodium proline symporter B34_03395 ENOG4107YHD transcriptional regulator B34_03397 ENOG4108PJD permease B34_03398 ENOG4105I82 acetyl xylan esterase B34_03402 ENOG4105E5Q amino acid AbC transporter B34_03403 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein B34_03404 ENOG4105NF4 modulator of drug activity B34_03406 ENOG4105CS2 ec 3.2.1.21 B34_03409 ENOG4107WDG serine threonine protein kinase B34_03410 ENOG4105C8Q Methyl-accepting chemotaxis B34_03411 ENOG4105C8Q Methyl-accepting chemotaxis B34_03417 ENOG4105F38 ABC transporter, permease B34_03418 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component B34_03419 ENOG4105CEY Amp-dependent synthetase and ligase B34_03423 ENOG4105SX7 Transporter B34_03425 ENOG4105W8Z 4'-phosphopantetheinyl transferase B34_03426 ENOG4108SA1 esterase B34_03430 ENOG4105CJ1 ABC, transporter B34_03435 ENOG4105CDA abc transporter atp-binding protein B34_03436 ENOG4105DRP amino acid AbC transporter B34_03438 ENOG4108JUB Transcriptional regulator B34_03439 ENOG4105C8Y Acetylornithine aminotransferase B34_03440 ENOG4108IQI permease B34_03441 ENOG41066UZ arginase EC 3.5.3.1 B34_03442 ENOG4106P55 Transcriptional regulator B34_03443 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase B34_03444 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) B34_03445 ENOG41069ZX B34_03446 ENOG41069ZX B34_03454 ENOG4107EV6 Inherit from COG: YD repeat protein B34_03458 ENOG4105C2F Histidine kinase B34_03459 ENOG4105EQD regulatoR B34_03460 ENOG4105DFW ABC transporter B34_03462 ENOG4108HWW ABC transporter B34_03463 ENOG4105DCM major facilitator superfamily B34_03464 ENOG410645S MarR family Transcriptional regulator B34_03465 ENOG4105C4C beta-galactosidase B34_03466 ENOG4107T32 3-phytase (EC 3.1.3.8) B34_03467 ENOG4105DUX Transporter B34_03470 ENOG4105E1K spore germination protein B34_03473 ENOG4107TXC Transcriptional regulator B34_03476 ENOG4107WD8 ABC transporter, permease B34_03477 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B34_03478 ENOG4105BZU Histidine kinase B34_03479 ENOG4105C8Q Methyl-accepting chemotaxis B34_03480 ENOG4105CFH Aspartokinase B34_03481 ENOG4105DHS permease protein B34_03482 ENOG4105CM4 permease protein B34_03483 ENOG4108IPW abc transporter atp-binding protein B34_03486 ENOG4105R8C Transcriptional regulator B34_03488 ENOG4108DBC nitroreductase B34_03489 ENOG41067V3 Antibiotic biosynthesis monooxygenase B34_03490 ENOG4105YVS arsR family transcriptional regulator B34_03492 ENOG4108JPW Aminotransferase B34_03493 ENOG4107QTZ amino acid B34_03494 ENOG4105C26 Dehydrogenase B34_03495 ENOG4108RNG Permease of the drug metabolite transporter B34_03497 ENOG4105KTB nuclear export factor GLE1 B34_03498 ENOG4108T5E Copper resistance protein B34_03499 ENOG4108ZYE Transcriptional regulator B34_03501 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) B34_03502 ENOG4108IFG nitrite reductase, (NAD(P)H) B34_03503 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit B34_03504 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B34_03505 ENOG4105DRR Transcriptional regulator, GntR family B34_03506 ENOG4105C8P )-transporter B34_03508 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia B34_03512 ENOG4108IUS Transketolase B34_03514 ENOG4105E7W lamb ycsf family protein B34_03515 ENOG4105C5A transporter B34_03516 ENOG4105CFM UPF0317 protein B34_03517 ENOG4105P4J Allophanate hydrolase, subunit 1 B34_03519 ENOG4107258 Transcriptional regulator B34_03520 ENOG4105XJB lipolytic protein G-D-S-L family B34_03523 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase B34_03524 ENOG4105ETD TRANSCRIPTIONal B34_03525 ENOG4105CYX Short-chain dehydrogenase reductase Sdr B34_03528 ENOG410606W general stress protein B34_03530 ENOG4108RCF TRANSCRIPTIONal B34_03531 ENOG4105VCH membrane B34_03534 ENOG4105C9U ATP-dependent DNA helicase RecQ B34_03535 ENOG4105C0X amino acid B34_03537 ENOG4108M1A Chitin-binding protein B34_03539 ENOG4105DQ6 Transposase B34_03542 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) B34_03543 ENOG4107BMA Transglycosylase associated protein B34_03544 ENOG4108IJ0 Aspartate ammonia-lyase B34_03545 ENOG41087PP glycosyltransferase MGT family B34_03546 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) B34_03547 ENOG4105EU9 B34_03549 ENOG41082W1 Cupin 2, conserved barrel domain protein B34_03550 ENOG4105QVS general stress protein B34_03551 ENOG4106F5Q Membrane B34_03552 ENOG4105CK2 sodium dicarboxylate symporter B34_03553 ENOG4105CJ1 ABC, transporter B34_03556 ENOG4105FDT acyl-CoA dehydrogenase B34_03559 ENOG4105SZ6 Thioredoxin B34_03560 ENOG4105CPF Cell wall formation (By similarity) B34_03561 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) B34_03563 ENOG4105C1J atp-dependent rna helicase B34_03564 ENOG410905X membrane-flanked domain protein B34_03565 ENOG4105CKV Membrane B34_03567 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein B34_03568 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B34_03570 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) B34_03571 ENOG4107MMM Anti-sigma-factor antagonist B34_03572 ENOG4105FUA antagonist B34_03573 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase B34_03574 ENOG4107SGM protein serine threonine phosphatase B34_03578 ENOG41064BQ Phosphatase B34_03580 ENOG4105ST3 Transcriptional regulator B34_03581 ENOG4105EYF MMPL domain protein B34_03590 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) B34_03591 ENOG41068WC Domain of unknown function (DUF955) B34_03592 ENOG4108IMY Transcriptional regulator B34_03595 ENOG4108RYM conjugative transposon protein B34_03596 ENOG4106BHR ftsk SpoIIIE family protein B34_03597 ENOG4106128 DNA-binding helix-turn-helix protein B34_03606 ENOG4105P1M Domain of unknown function (DUF1874) B34_03608 ENOG4105K4H Nlp p60 protein B34_03616 ENOG4105VZ8 Transcriptional regulator B34_03617 ENOG4105ECK Fatty Acid Desaturase B34_03618 ENOG4105VEQ Cold shock protein B34_03622 ENOG4108U05 Transcriptional regulator B34_03623 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 B34_03626 ENOG4105KVH Transcriptional regulator B34_03628 ENOG4108VP3 Lysine exporter protein (LysE YggA) B34_03632 ENOG4107XCH Cyclase family B34_03633 ENOG4105C85 amino acid B34_03636 ENOG4105JVQ RNA Polymerase B34_03637 ENOG4108P49 AntiSigma factor B34_03638 ENOG4105EXC Acyl-transferase B34_03639 ENOG4105C2C drug resistance transporter, Bcr CflA B34_03641 ENOG4108NEV two component transcriptional regulator, LytTR family B34_03643 ENOG4108Z6X (sortase) family B34_03644 ENOG4107QNK )-transporter B34_03652 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) B34_03653 ENOG4105K8N protein family UPF0079, ATPase B34_03654 ENOG41072GX Peptidase M22 Glycoprotease B34_03655 ENOG410801F ribosomal-protein-alanine acetyltransferase B34_03656 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B34_03657 ENOG4105C5H ABC transporter B34_03659 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) B34_03660 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) B34_03661 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B34_03663 ENOG4108TYN CAAX amino terminal protease family protein B34_03664 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) B34_03665 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) B34_03671 ENOG41073R8 VanW family B34_03674 ENOG4108RAV Conserved protein B34_03675 ENOG4108X07 Tetr family transcriptional regulator B34_03676 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B34_03678 ENOG4105K78 MarR family Transcriptional regulator B34_03679 ENOG4108VHC Short-chain dehydrogenase reductase Sdr B34_03680 ENOG4105EBR Carboxylesterase B34_03682 ENOG41087YS Phage shock protein A B34_03683 ENOG4105DQX Zinc finger domain B34_03684 ENOG4108WV1 Pfam:DUF477 B34_03687 ENOG4108NGU Transcriptional regulator B34_03688 ENOG4105N14 lysine exporter protein LysE YggA B34_03690 ENOG4105CNI cell division protein FtsW B34_03691 ENOG4105CNI cell division protein FtsW B34_03695 ENOG4108ZJ4 polysaccharide deacetylase B34_03696 ENOG4105E5K Alpha-amylase B34_03698 ENOG4105FKQ transcriptional regulator B34_03699 ENOG4108IUK alpha amylase, catalytic B34_03700 ENOG4107FKK extracellular solute-binding protein family 1 B34_03701 ENOG4105D56 permease protein B34_03702 ENOG4105EG2 ABC transporter, permease B34_03705 ENOG4105CG3 alpha amylase, catalytic region B34_03706 ENOG4107URF beta-phospho-glucomutase B34_03707 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B34_03708 ENOG4105GVJ transcriptional regulator B34_03719 ENOG4108W3Q Transcriptional regulator B34_03720 ENOG4107STQ Multicopper oxidase B34_03724 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B34_03727 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) B34_03728 ENOG4105C7N Xanthine uracil vitamin C permease B34_03731 ENOG4108U5N UPF0316 protein B34_03733 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) B34_03734 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit B34_03735 ENOG4105C83 adenylosuccinate lyase B34_03736 ENOG4105C8V SAICAR synthetase B34_03737 ENOG4105VR9 phosphoribosylformylglycinamidine synthase B34_03739 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii B34_03741 ENOG4105CXB phosphoribosylaminoimidazole synthetase B34_03742 ENOG4108V3E phosphoribosylglycinamide formyltransferase B34_03743 ENOG4105DC1 bifunctional purine biosynthesis protein purh B34_03744 ENOG4105C12 Phosphoribosylglycinamide synthetase B34_03746 ENOG4106A3M Cytochrome p-450 B34_03752 ENOG4108R5T secreted protein B34_03753 ENOG4105KGF protein, YerC YecD B34_03755 ENOG4105C4R Atp-dependent dna helicase B34_03756 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) B34_03758 ENOG4108M21 B34_03760 ENOG4105MUZ Protein of unknown function DUF2620 B34_03761 ENOG4106M0N transport system permease protein B34_03762 ENOG41080QX K07048 phosphotriesterase-related protein B34_03763 ENOG4106PKC pyridoxal phosphate binding B34_03764 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) B34_03765 ENOG4108626 Racemase B34_03766 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) B34_03767 ENOG4105KT7 mgtC SapB transporter B34_03768 ENOG4105CK7 Sodium proline symporter B34_03770 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) B34_03771 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B34_03772 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) B34_03775 ENOG4105D3P Mannan endo-1,4-beta-mannosidase B34_03776 ENOG4108IG5 Transcriptional regulator B34_03779 ENOG4105D9U N-acetyltransferase B34_03780 ENOG4105DU0 nucleoside hydrolase B34_03781 ENOG4105CBD Diacylglycerol kinase B34_03782 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B34_03784 ENOG4105C5Y PTS System B34_03785 ENOG4105CS2 ec 3.2.1.21 B34_03786 ENOG4105CID antiterminator B34_03787 ENOG410780I phosphoprotein phosphatase activity B34_03791 ENOG4105CDY transcriptional regulatory protein B34_03794 ENOG4105C26 Dehydrogenase B34_03795 ENOG4105FKZ Methyl-accepting chemotaxis B34_03796 ENOG4105C8P )-transporter B34_03797 ENOG4105C5H ABC transporter B34_03799 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) B34_03800 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase B34_03803 ENOG4105CKI cobalamin synthesis protein B34_03804 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) B34_03805 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B34_03806 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) B34_03807 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) B34_03808 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) B34_03809 ENOG4106A3M Cytochrome p-450 B34_03811 ENOG4107SWG transcriptional regulator MERR family B34_03812 ENOG4105DXB Major Facilitator superfamily B34_03813 ENOG4105C5H ABC transporter B34_03814 ENOG4105FDU atp-dependent rna helicase B34_03815 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein B34_03817 ENOG4107QPK )-transporter B34_03824 ENOG41082BM Transcriptional regulator, arsr family B34_03825 ENOG410855V Acylphosphatase B34_03826 ENOG4108RPX mosc domain containing protein B34_03829 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) B34_03833 ENOG4105C5Y PTS System B34_03834 ENOG4105CG3 alpha amylase, catalytic region B34_03835 ENOG4107414 GntR family transcriptional regulator B34_03840 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B34_03841 ENOG4105D7W serine acetyltransferase B34_03842 ENOG4108IAJ Nad-dependent epimerase dehydratase B34_03845 ENOG4107TVC Glycosyl transferase, family 2 B34_03848 ENOG4107QQG Dehydrogenase B34_03850 ENOG4105KVH Transcriptional regulator B34_03851 ENOG4108RCM Nitroreductase B34_03852 ENOG4105CGH 5'-nucleotidase B34_03853 ENOG4107RKG DJ-1/PfpI family B34_03855 ENOG4105BZG amino acid carrier protein B34_03856 ENOG4105KJF protein tyrosine phosphatase B34_03858 ENOG4107U9T Pfam:Ribonuclease_BN B34_03860 ENOG4108ISG Major Facilitator B34_03862 ENOG4105UPD Calcium Proton B34_03867 ENOG4105DCT glycerol dehydrogenase B34_03869 ENOG4105D7N magnesium and cobalt transport protein CorA B34_03871 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B34_03879 ENOG41079KZ Major Facilitator Superfamily B34_03884 ENOG4105EVH UPF0753 protein B34_03885 ENOG4108TWJ NADH dehydrogenase subunit 5 B34_03886 ENOG4105GPN Uncharacterized conserved protein (DUF2294) B34_03888 ENOG4107RUY (E1 component), alpha subunit B34_03890 ENOG4107QKR Dehydrogenase B34_03892 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family B34_03893 ENOG4105KK4 UPF0060 membrane protein B34_03894 ENOG4105F8D glycoside hydrolase family 4 B34_03895 ENOG4108Q3X Transcriptional regulator B34_03896 ENOG4105CI1 PTS System B34_03899 ENOG4105KVH Transcriptional regulator B34_03901 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B34_03902 ENOG4105E4I Glycoside hydrolase family 28 B34_03903 ENOG4105DSG hydrolase family 43 B34_03904 ENOG4106HBX Transcriptional Regulator AraC Family B34_03907 ENOG4105DYS nad(p)h dehydrogenase (quinone) B34_03912 ENOG4105JAB phenazine biosynthesis protein, phzf family B34_03913 ENOG4107Y03 Nitroreductase B34_03917 ENOG4105ECP epimerase B34_03918 ENOG410691R Modulates RecA activity (By similarity) B34_03923 ENOG4105CKK Glycosyl transferase, family 2 B34_03925 ENOG4105EJV Membrane B34_03926 ENOG41067AE Membrane-bound metal-dependent hydrolase B34_03927 ENOG4105CEN a g-specific adenine glycosylase B34_03928 ENOG4106BXE B34_03929 ENOG4105CAN Short-chain dehydrogenase reductase Sdr B34_03933 ENOG4105BZ1 (ABC) transporter B34_03934 ENOG4105C3U ABC transporter B34_03935 ENOG4108JQ7 (ABC) transporter B34_03936 ENOG4105DEF Extracellular solute-binding protein, family 5 B34_03937 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B34_03938 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B34_03939 ENOG4107NBY Membrane B34_03940 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase B34_03941 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B34_03942 ENOG4105G5W regulator Fur family B34_03943 ENOG4105TUA UPF0295 protein B34_03997 ENOG4105CAR Terminase, large subunit B34_04000 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B34_04010 ENOG4108FKH Transglycosylase SLT domain B34_04012 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj B34_04014 ENOG41068G1 B34_04021 ENOG4107EV6 Inherit from COG: YD repeat protein B34_04026 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B34_04028 ENOG410780I phosphoprotein phosphatase activity B34_04034 ENOG4107EV6 Inherit from COG: YD repeat protein B34_04036 ENOG4105C22 threonyL-tRNA synthetase B34_04037 ENOG4105FF2 Type I DHQase B34_04038 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) B34_04039 ENOG4105D7T ABC transporter B34_04040 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein B34_04041 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component B34_04042 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) B34_04043 ENOG4107D63 B34_04044 ENOG4105VZ8 Transcriptional regulator B34_04046 ENOG4105DA5 (ABC) transporter B34_04050 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) B34_04053 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) B34_04055 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) B34_04059 ENOG4105CYN Serine protein kinase B34_04060 ENOG4106AKX UPF0229 protein B34_04061 ENOG4105CW7 secretion protein, HlyD family B34_04062 ENOG4105C0R drug resistance transporter emrb qaca subfamily B34_04063 ENOG4105CS1 NAD(P)H quinone oxidoreductase B34_04065 ENOG4105CZV ABC transporter B34_04066 ENOG4105CJ1 ABC, transporter B34_04067 ENOG4108TU7 Inherit from COG: (ABC) transporter B34_04068 ENOG4105DQ6 Transposase B34_04070 ENOG4105VEQ Cold shock protein B34_04071 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B34_04072 ENOG4108UMI ABC transporter, permease B34_04074 ENOG4107R6U sodium dicarboxylate symporter B34_04080 ENOG4105BZU Histidine kinase B34_04083 ENOG4108YBP pseudouridine synthase B34_04085 ENOG41080XP Cbs domain B34_04086 ENOG4107YBY Hydrolase B34_04087 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B34_04089 ENOG4105C5H ABC transporter B34_04090 ENOG4105TMB Formate nitrite transporter B34_04091 ENOG4105RK9 auxin efflux carrier B34_04092 ENOG4105CB2 alcohol dehydrogenase B34_04093 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B34_04095 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) B34_04097 ENOG4105C6V Glycerol-3-phosphate dehydrogenase B34_04101 ENOG4105BZU Histidine kinase B34_04102 ENOG4105WH1 Two component transcriptional regulator luxr family B34_04106 ENOG4105KPV Transcriptional regulator B34_04107 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) B34_04108 ENOG4105ED1 spovr family B34_04111 ENOG4105BZN citrate synthase B34_04113 ENOG4105CYX Short-chain dehydrogenase reductase Sdr B34_04114 ENOG4105C8J )-transporter B34_04116 ENOG41086D8 Transcriptional regulator B34_04117 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B34_04120 ENOG4105J37 B34_04121 ENOG4108AEY RNA polymerase sigma factor B34_04122 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein B34_04124 ENOG4105F6E Acyl-transferase B34_04126 ENOG4105KAF membrAne B34_04128 ENOG4105U5Y Transcriptional regulator B34_04129 ENOG4105C37 (CBS) domain B34_04132 ENOG4105C37 (CBS) domain B34_04138 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B34_04140 ENOG4105D64 Mechanosensitive ion channel B34_04141 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) B34_04144 ENOG4107VMI polysaccharide deacetylase B34_04145 ENOG4105F0I Aminotransferase B34_04147 ENOG4108N2V aldose 1-epimerase B34_04152 ENOG4105BZ1 (ABC) transporter B34_04153 ENOG4105BZ1 (ABC) transporter B34_04161 ENOG410839P B34_04163 ENOG4106MP8 UPF0754 membrane protein B34_04164 ENOG4105WZB UPF0342 protein B34_04166 ENOG4105D4P Coproporphyrinogen iii oxidase B34_04167 ENOG4107S91 Sodium hydrogen exchanger B34_04168 ENOG4105NCW Trka-c domain protein B34_04170 ENOG4105CGU Enoyl-CoA hydratase B34_04175 ENOG4108IUX (ABC) transporter B34_04176 ENOG4105RHA ABC transporter, permease B34_04177 ENOG4107VRP DNA repair exonuclease B34_04178 ENOG4106D4I domain protein B34_04179 ENOG4105EQI Metal Dependent Phosphohydrolase B34_04181 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B34_04188 ENOG4105NBU tryptophan transport protein B34_04189 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) B34_04190 ENOG4105K59 histidine triad (HIT) protein B34_04196 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation B34_04197 ENOG4105BZ4 penicillin-binding protein B34_04198 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) B34_04199 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B34_04200 ENOG4105C1Q protoporphyrinogen oxidase B34_04202 ENOG4105ECB domain protein B34_04204 ENOG4105DER m42 family B34_04207 ENOG4106AXD B34_04208 ENOG4108RQ5 Beta-lactamase domain-containing protein B34_04209 ENOG4105DF9 Lipoate-protein, ligase B34_04210 ENOG4105CEY Amp-dependent synthetase and ligase B34_04212 ENOG4108JCI Transcriptional regulator B34_04215 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 B34_04216 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B34_04217 ENOG4108UZ3 Transporter B34_04218 ENOG4108HUF Transporter B34_04219 ENOG4105DQ5 transport system permease protein B34_04220 ENOG4108U1V ABC transporter, permease B34_04221 ENOG4107TB6 phosphoglycerate mutase B34_04222 ENOG4106YBV Methyl-accepting chemotaxis B34_04226 ENOG4105XVF Competence transcription factor B34_04227 ENOG41060YP B34_04230 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin B34_04232 ENOG4105G9B Transcriptional regulator B34_04234 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) B34_04235 ENOG4105CE7 Amidase, hydantoinase carbamoylase family B34_04236 ENOG4105S0E allantoin catabolism protein B34_04237 ENOG4105DG4 malate L-lactate dehydrogenase B34_04238 ENOG4105DG4 malate L-lactate dehydrogenase B34_04239 ENOG4105DG4 malate L-lactate dehydrogenase B34_04240 ENOG4107R1Q Membrane protein FdrA B34_04241 ENOG4107REC cytoplasmic protein B34_04243 ENOG4105C5B carbamate kinase B34_04244 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) B34_04245 ENOG4107CUJ Protein of unknown function (DUF2690) B34_04246 ENOG410780I phosphoprotein phosphatase activity B34_04252 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component B34_04253 ENOG4105I1K ABC transporter B34_04255 ENOG4108KK1 membrane protein AbrB duplication B34_04258 ENOG4105WEF catalase B34_04259 ENOG4105CEY Amp-dependent synthetase and ligase B34_04260 ENOG4106K7D Major facilitator family transporter B34_04262 ENOG4105BZU Histidine kinase B34_04263 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B34_04265 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein B34_04266 ENOG4105E0C molybdate abc transporter B34_04268 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation B34_04270 ENOG4105EYH Exonuclease B34_04277 ENOG410751J B34_04281 ENOG4105ERH Fumarylacetoacetate hydrolase B34_04286 ENOG4105CAQ asparagine synthetase B34_04289 ENOG4108YZA Nitrogen regulatory protein pii B34_04290 ENOG4105UQX Mate efflux family protein B34_04291 ENOG4106HBX Transcriptional Regulator AraC Family B34_04293 ENOG4105ETE Transcriptional regulator (LacI family B34_04294 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) B34_04295 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) B34_04300 ENOG4108ZUB Lysine exporter protein (Lyse ygga) B34_04301 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B34_04303 ENOG4105DY8 decarboxylase B34_04308 ENOG4105MA6 gCN5-related N-acetyltransferase B34_04309 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B34_04310 ENOG4105D29 Helix-turn-helix type 11 domain protein B34_04313 ENOG4108VPT UPF0234 protein B34_04314 ENOG4105QNR S1 RNA binding domain protein B34_04317 ENOG4105EPR degv family B34_04318 ENOG4107AYK membrAne B34_04320 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) B34_04321 ENOG41073B9 B34_04322 ENOG4108KP7 hydrolase B34_04323 ENOG4108MXZ Esterase B34_04324 ENOG4105VG1 fes assembly suf system protein B34_04325 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase B34_04326 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) B34_04327 ENOG4105CAS nag kinase B34_04328 ENOG4105C8Y Acetylornithine aminotransferase B34_04329 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain B34_04331 ENOG4105DBV ornithine carbamoyltransferase B34_04332 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B34_04337 ENOG4107RMD Basic membrane lipoprotein B34_04340 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B34_04341 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) B34_04343 ENOG4105C3U ABC transporter B34_04344 ENOG4108JQ7 (ABC) transporter B34_04347 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B34_04352 ENOG4105C31 Tryptophanyl-tRNA synthetase B34_04353 ENOG4108J59 Extracellular solute-binding protein, family 5 B34_04354 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B34_04355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B34_04357 ENOG4108JQ7 (ABC) transporter B34_04359 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) B34_04360 ENOG4108ZCF integral membrane protein B34_04361 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis B34_04365 ENOG4108V9W transcriptional regulatory protein B34_04366 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism B34_04368 ENOG4105DPN Oligoendopeptidase f B34_04370 ENOG4105T58 Dithiol-disulfide isomerase B34_04371 ENOG4108Z18 K06886 hemoglobin B34_04372 ENOG4105E4C Lytic transglycosylase catalytic B34_04373 ENOG4105MIX Adenylate cyclase B34_04374 ENOG4106EFP UPF0738 protein B34_04376 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) B34_04377 ENOG4105EMS pseudouridine synthase B34_04378 ENOG4107S1Q Phosphatase B34_04380 ENOG4105ETU transcriptional activator (TenA B34_04381 ENOG4108VEU Thiamine monophosphate synthase B34_04384 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) B34_04385 ENOG4105D06 uba thif-type nad fad binding protein B34_04386 ENOG4105DWF phosphomethylpyrimidine kinase B34_04387 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH B34_04388 ENOG4107A88 B34_04398 ENOG4105ENA helicase B34_04400 ENOG4107T5V SNARE associated Golgi B34_04401 ENOG4105CMR udp-glucose 4-epimerase B34_04402 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B34_04405 ENOG4108ZMI UPF0477 protein B34_04409 ENOG4105C28 cystathionine B34_04410 ENOG4105C28 cystathionine B34_04411 ENOG4105JHY Membrane B34_04414 ENOG4105FQP Beta-lactamase B34_04415 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase B34_04418 ENOG4108UW5 maltose o-acetyltransferase B34_04420 ENOG4105DUM transcriptional regulator, lysR family B34_04421 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B34_04422 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) B34_04424 ENOG4108Q5Y Membrane B34_04425 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase B34_04427 ENOG41069ER domain protein B34_04428 ENOG4105C0R drug resistance transporter emrb qaca subfamily B34_04429 ENOG4105J7D transcriptional regulator B34_04433 ENOG4107EV6 Inherit from COG: YD repeat protein B34_04434 ENOG4105K7W phage-related replication protein B34_04435 ENOG410635T phage-like element pbsx protein B34_04445 ENOG4108TFU terminase (Small subunit) B34_04446 ENOG4105IG6 Phage terminase, large subunit B34_04447 ENOG4108MDF Phage Portal Protein B34_04448 ENOG4108MDF Phage Portal Protein B34_04453 ENOG41060SN B34_04456 ENOG4105PQS phage protein B34_04457 ENOG4105FR7 XkdM protein, phage-like element PBSX B34_04458 ENOG4105MTC XkdN-like protein B34_04459 ENOG4108FKH Transglycosylase SLT domain B34_04460 ENOG4108WZM domain protein B34_04461 ENOG4105X7F B34_04463 ENOG4105MFU Protein of unknown function (DUF2634) B34_04464 ENOG41066EA baseplate J family protein B34_04465 ENOG410906S phage-like element pbsx protein xkdt B34_04467 ENOG41068G1 B34_04468 ENOG41068G1 B34_04471 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B34_04472 ENOG4107XBN GntR Family Transcriptional Regulator B34_04473 ENOG4105CPQ Dehydrogenase B34_04474 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) B34_04475 ENOG4105DMW Dehydrogenase reductase B34_04476 ENOG4105CPQ Dehydrogenase B34_04477 ENOG4108I5G Major Facilitator superfamily B34_04480 ENOG4105CJ3 phosphate transporter B34_04481 ENOG4107GRR phosphate transport regulator B34_04482 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) B34_04485 ENOG4105C2F Histidine kinase B34_04486 ENOG4105EQD regulatoR B34_04487 ENOG410769Z extracellular solute-binding protein family 1 B34_04488 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component B34_04489 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component B34_04490 ENOG4105F5H Glycosyl Hydrolase Family 88 B34_04491 ENOG41075H3 AraC family transcriptional regulator B34_04492 ENOG4107TDE lipolytic protein G-D-S-L family B34_04495 ENOG4105CX8 fg-gap repeat protein B34_04497 ENOG4107TDE lipolytic protein G-D-S-L family B34_04498 ENOG4105CX8 fg-gap repeat protein B34_04499 ENOG4105CPC Aldo Keto reductase B34_04500 ENOG4107TDE lipolytic protein G-D-S-L family B34_04502 ENOG4105EKC B34_04503 ENOG4105E0S extracellular solute-binding protein family 1 B34_04505 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component B34_04506 ENOG4107R7I amino acid B34_04509 ENOG4105C0H protease B34_04511 ENOG4108ME1 Peptidase M55 D-aminopeptidase B34_04512 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B34_04513 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B34_04514 ENOG4105C3U ABC transporter B34_04516 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B34_04517 ENOG4105DTQ mandelate racemase muconate lactonizing B34_04518 ENOG4107SN7 NLP P60 protein B34_04519 ENOG4108JQ7 (ABC) transporter B34_04520 ENOG4107TUM Amidinotransferase B34_04521 ENOG4108S4H thioesterase Superfamily protein B34_04523 ENOG4108J20 pectate lyase B34_04529 ENOG410839T multidrug resistance protein B34_04530 ENOG41080TC multidrug resistance protein B34_04531 ENOG4105CIY formyltetrahydrofolate deformylase B34_04532 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) B34_04533 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) B34_04535 ENOG4105K56 Transcriptional regulator B34_04536 ENOG4108ZHJ Organic hydroperoxide resistance protein B34_04538 ENOG4107Y2X deaminase B34_04539 ENOG4105CVJ phosphoglycerate mutase B34_04542 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) B34_04543 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B34_04545 ENOG4105CJW magnesium transporter B34_04547 ENOG4105V75 Transcriptional regulator B34_04552 ENOG4105DQE DNA ligase B34_04553 ENOG4105FDF Could be involved in DNA repair (By similarity) B34_04554 ENOG4105BZU Histidine kinase B34_04555 ENOG4107T5V SNARE associated Golgi B34_04556 ENOG4107TS3 membrane protein, TerC B34_04557 ENOG4108WZW RNA polymerase sigma B34_04559 ENOG410681C small acid-soluble spore protein B34_04561 ENOG4105D0M Protease HtpX homolog B34_04563 ENOG4107RVG penicillin-binding protein B34_04566 ENOG4108TGC Acyltransferase B34_04567 ENOG4105BZU Histidine kinase B34_04568 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B34_04570 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) B34_04572 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B34_04574 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate B34_04576 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) B34_04577 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) B34_04580 ENOG4105BZU Histidine kinase B34_04581 ENOG41090MY MarR family Transcriptional regulator B34_04582 ENOG4105ER2 Ompa motb domain protein B34_04583 ENOG4105E14 MotA TolQ exbB proton channel B34_04585 ENOG4108K88 Membrane B34_04586 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) B34_04587 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase B34_04588 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) B34_04589 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) B34_04590 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B34_04591 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B34_04596 ENOG4108J9Q DNA ligase B34_04601 ENOG4107EV6 Inherit from COG: YD repeat protein B34_04640 ENOG41068G1 B34_04644 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B34_04650 ENOG4105VTR Integrase B34_04651 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) B34_04656 ENOG4105NX3 Membrane B34_04657 ENOG4105VMP Transcriptional regulator B34_04666 ENOG4105F0V Cell wall hydrolase B34_04669 ENOG4105C59 p-type ATPase B34_04670 ENOG4105DC7 peptidase M24 B34_04674 ENOG4105CID antiterminator B34_04676 ENOG4105KRI phosphocarrier protein (HPr B34_04677 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) B34_04679 ENOG4105F6S Spore photoproduct lyase B34_04681 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B34_04682 ENOG4105CHR reductase B34_04683 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B34_04684 ENOG4105K4I Scp-like extracellular B34_04686 ENOG4105BZU Histidine kinase B34_04687 ENOG4105CHM Aminotransferase B34_04691 ENOG4107R88 Chemotaxis protein (CheV) B34_04692 ENOG4105UIN B34_04694 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein B34_04696 ENOG4105K6S Short-chain dehydrogenase reductase Sdr B34_04697 ENOG4105EPM Diguanylate phosphodiesterase B34_04699 ENOG4107IN1 Protein of unknown function (DUF1797) B34_04701 ENOG4108XRC Protein of unknown function (DUF458) B34_04707 ENOG4105NQC Flavodoxin B34_04708 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) B34_04711 ENOG4105D3R alkyl hydroperoxide reductase B34_04712 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B34_04715 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) B34_04716 ENOG4105D06 uba thif-type nad fad binding protein B34_04717 ENOG4105CVM Molybdenum cofactor synthesis domain protein B34_04718 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein B34_04719 ENOG4108ZAF Molybdopterin B34_04720 ENOG41067WU Molybdopterin converting factor (Subunit 1) B34_04722 ENOG4105BZ1 (ABC) transporter B34_04723 ENOG4105BZ1 (ABC) transporter B34_04725 ENOG4107X8C Efflux transporter RND family MFP subunit B34_04726 ENOG4105C19 ABC transporter B34_04727 ENOG4107RBB ABC transporter, permease B34_04728 ENOG4105E98 transcriptional regulator DeoR family B34_04729 ENOG4105DE4 1-phosphofructokinase B34_04730 ENOG4105DM4 PTS System B34_04731 ENOG4105C3F Signal peptidase i B34_04734 ENOG4105C5H ABC transporter