locus-tag	class	description
S100027_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S100027_00002	COG0592	DNA-directed DNA polymerase activity
S100027_00003	COG2501	S4 domain
S100027_00004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S100027_00005	COG0187	DNA topoisomerase II activity
S100027_00006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S100027_00013	COG0517	IMP dehydrogenase activity
S100027_00013	COG0516	GMP reductase activity
S100027_00014	COG1686	Belongs to the peptidase S11 family
S100027_00015	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
S100027_00016	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
S100027_00017	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S100027_00018	COG1929	Belongs to the glycerate kinase type-1 family
S100027_00019	COG2610	gluconate transmembrane transporter activity
S100027_00020	COG2610	gluconate transmembrane transporter activity
S100027_00021	COG3835	regulator
S100027_00024	COG1428	Deoxynucleoside kinase
S100027_00025	COG1428	Deoxynucleoside kinase
S100027_00026	COG3858	chitin binding
S100027_00026	COG1388	LysM domain
S100027_00027	COG1335	isochorismatase
S100027_00028	COG0590	tRNA wobble adenosine to inosine editing
S100027_00029	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S100027_00030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S100027_00031	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S100027_00040	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
S100027_00041	COG3853	Toxic anion resistance protein (TelA)
S100027_00042	COG1982	Orn Lys Arg decarboxylase major
S100027_00043	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S100027_00044	COG3870	Protein conserved in bacteria
S100027_00045	COG1728	Protein conserved in bacteria
S100027_00046	COG0470	DNA polymerase III
S100027_00047	COG1774	PSP1 C-terminal conserved region
S100027_00048	COG4467	Involved in initiation control of chromosome replication
S100027_00049	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S100027_00050	COG2827	Endonuclease containing a URI domain
S100027_00051	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S100027_00052	COG2002	toxin-antitoxin pair type II binding
S100027_00053	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100027_00053	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100027_00054	COG0084	hydrolase, TatD family'
S100027_00055	COG3584	3D domain protein
S100027_00055	COG3583	domain protein
S100027_00056	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S100027_00057	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S100027_00059	COG4466	Protein conserved in bacteria
S100027_00062	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S100027_00063	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100027_00064	COG0251	oxidation-reduction process
S100027_00065	COG2088	sporulation resulting in formation of a cellular spore
S100027_00066	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S100027_00067	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S100027_00068	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S100027_00069	COG0193	aminoacyl-tRNA hydrolase activity
S100027_00071	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S100027_00072	COG2002	toxin-antitoxin pair type II binding
S100027_00073	COG2244	polysaccharide biosynthetic process
S100027_00074	COG3956	TIGRFAM MazG family protein
S100027_00075	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S100027_00078	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S100027_00079	COG1098	S1 RNA binding domain
S100027_00082	COG2208	phosphoserine phosphatase activity
S100027_00083	COG2304	oxidoreductase activity
S100027_00084	COG0515	serine threonine protein kinase
S100027_00085	COG0037	tRNA processing
S100027_00087	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S100027_00088	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S100027_00089	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S100027_00090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100027_00091	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100027_00092	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S100027_00093	COG0512	Glutamine amidotransferase of anthranilate synthase
S100027_00094	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100027_00095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S100027_00096	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S100027_00097	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S100027_00098	COG1396	sequence-specific DNA binding
S100027_00099	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100027_00100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S100027_00116	COG4463	regulation of RNA biosynthetic process
S100027_00117	COG3880	PFAM UvrB UvrC protein
S100027_00118	COG3869	Catalyzes the specific phosphorylation of arginine residues in
S100027_00119	COG0542	response to heat
S100027_00120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S100027_00121	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
S100027_00122	COG4956	integral membrane protein (PIN domain superfamily)
S100027_00123	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S100027_00124	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S100027_00125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S100027_00126	COG1045	serine acetyltransferase
S100027_00127	COG0215	cysteine-tRNA ligase activity
S100027_00128	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S100027_00129	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100027_00130	COG3688	RNA-binding protein containing a PIN domain
S100027_00133	COG0250	Participates in transcription elongation, termination and antitermination
S100027_00134	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S100027_00135	COG0081	regulation of translation
S100027_00136	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S100027_00137	COG0222	ribosome binding
S100027_00138	COG2813	Specifically methylates the guanine in position
S100027_00139	COG0085	RNA polymerase activity
S100027_00140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S100027_00141	COG1358	cellular component organization or biogenesis
S100027_00142	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S100027_00143	COG0049	tRNA binding
S100027_00144	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S100027_00145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S100027_00146	COG0051	transcription antitermination factor activity, RNA binding
S100027_00147	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S100027_00148	COG0088	Forms part of the polypeptide exit tunnel
S100027_00149	COG0089	rRNA binding
S100027_00150	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S100027_00151	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S100027_00152	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S100027_00153	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S100027_00154	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S100027_00155	COG0255	Belongs to the universal ribosomal protein uL29 family
S100027_00156	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S100027_00157	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S100027_00158	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S100027_00159	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S100027_00160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100027_00161	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S100027_00162	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S100027_00163	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S100027_00164	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S100027_00165	COG1841	ribosomal large subunit assembly
S100027_00166	COG0200	Binds to the 23S rRNA
S100027_00167	COG0201	protein transport
S100027_00168	COG0563	adenylate kinase activity
S100027_00169	COG0024	Methionine aminopeptidase
S100027_00170	COG2163	COG2163 Ribosomal protein L14E L6E L27E
S100027_00171	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S100027_00172	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S100027_00173	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S100027_00174	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S100027_00175	COG0202	RNA polymerase activity
S100027_00176	COG0203	ribosomal protein L17
S100027_00177	COG1122	ATPase activity
S100027_00178	COG1122	ATPase activity
S100027_00179	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100027_00180	COG0101	tRNA pseudouridine synthase activity
S100027_00181	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S100027_00182	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S100027_00183	COG2318	DinB family
S100027_00185	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100027_00186	COG0489	protein tyrosine kinase activity
S100027_00188	COG2194	sulfuric ester hydrolase activity
S100027_00189	COG0726	polysaccharide deacetylase
S100027_00196	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100027_00198	COG0385	Bile acid
S100027_00201	COG3876	Protein conserved in bacteria
S100027_00202	COG1472	Belongs to the glycosyl hydrolase 3 family
S100027_00203	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100027_00204	COG1263	PTS System
S100027_00204	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_00205	COG1737	Transcriptional regulator
S100027_00206	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S100027_00207	COG1683	Conserved Protein
S100027_00214	COG1595	DNA-templated transcription, initiation
S100027_00215	COG5662	AntiSigma factor
S100027_00216	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S100027_00217	COG4856	YbbR-like protein
S100027_00218	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100027_00219	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S100027_00222	COG1131	(ABC) transporter
S100027_00223	COG1725	Transcriptional regulator
S100027_00224	COG0640	Transcriptional regulator
S100027_00225	COG2814	Major facilitator Superfamily
S100027_00227	COG1132	(ABC) transporter
S100027_00228	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S100027_00233	COG1011	Hydrolase
S100027_00234	COG1113	amino acid transport
S100027_00235	COG2851	Citrate transporter
S100027_00236	COG3181	Tripartite tricarboxylate transporter family receptor
S100027_00237	COG4565	transcriptional regulatory protein
S100027_00238	COG3290	protein histidine kinase activity
S100027_00241	COG2211	Major facilitator Superfamily
S100027_00245	COG1331	Highly conserved protein containing a thioredoxin domain
S100027_00246	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
S100027_00247	COG1331	Highly conserved protein containing a thioredoxin domain
S100027_00248	COG0477	Major facilitator Superfamily
S100027_00252	COG1283	sodium-dependent phosphate transmembrane transporter activity
S100027_00253	COG4682	membrane
S100027_00258	COG0697	spore germination
S100027_00259	COG1917	Cupin 2, conserved barrel domain protein
S100027_00259	COG2207	Transcriptional regulator
S100027_00263	COG0371	Dehydrogenase
S100027_00264	COG0840	transmembrane signaling receptor activity
S100027_00265	COG4213	ABC transporter substrate-binding protein
S100027_00268	COG4257	antibiotic catabolic process
S100027_00270	COG0833	amino acid
S100027_00271	COG2040	homocysteine
S100027_00273	COG2190	(PTS) system
S100027_00273	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_00273	COG1263	PTS System
S100027_00274	COG0789	Transcriptional regulator
S100027_00275	COG2323	membrane
S100027_00277	COG2205	protein histidine kinase activity
S100027_00278	COG1115	amino acid carrier protein
S100027_00279	COG2066	Belongs to the glutaminase family
S100027_00280	COG4191	Histidine kinase
S100027_00281	COG0784	Response regulator, receiver
S100027_00286	COG3540	Alkaline phosphatase
S100027_00287	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100027_00288	COG0805	protein transport
S100027_00289	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100027_00290	COG1012	belongs to the aldehyde dehydrogenase family
S100027_00291	COG2271	Major facilitator Superfamily
S100027_00292	COG4948	Mandelate Racemase Muconate Lactonizing
S100027_00293	COG2186	Transcriptional regulator
S100027_00294	COG2721	sulfolactate sulfo-lyase activity
S100027_00295	COG0745	RESPONSE REGULATOR receiver
S100027_00296	COG2205	protein histidine kinase activity
S100027_00297	COG1131	(ABC) transporter
S100027_00302	COG3173	Aminoglycoside phosphotransferase
S100027_00303	COG1846	Transcriptional regulator
S100027_00304	COG0318	PFAM AMP-dependent synthetase and ligase
S100027_00308	COG0789	Transcriptional regulator
S100027_00313	COG0697	spore germination
S100027_00314	COG1714	RDD family
S100027_00315	COG3012	SEC-C Motif Domain Protein
S100027_00315	COG1405	negative regulation of cell septum assembly
S100027_00321	COG0583	DNA-binding transcription factor activity
S100027_00322	COG1942	4-Oxalocrotonate Tautomerase
S100027_00323	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_00326	COG1288	antiporter activity
S100027_00328	COG0456	acetyltransferase
S100027_00330	COG1164	Oligoendopeptidase f
S100027_00331	COG2261	transglycosylase associated protein
S100027_00333	COG0247	lactate metabolic process
S100027_00334	COG0277	FAD linked oxidase domain protein
S100027_00335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100027_00336	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100027_00337	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100027_00338	COG1486	melibiose metabolic process
S100027_00340	COG3394	polysaccharide catabolic process
S100027_00344	COG3591	Belongs to the peptidase S1B family
S100027_00345	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_00347	COG1595	DNA-templated transcription, initiation
S100027_00349	COG3773	Cell wall hydrolase
S100027_00350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100027_00351	COG3883	PFAM NLP P60 protein
S100027_00351	COG0791	NLP P60 protein
S100027_00353	COG1131	(ABC) transporter
S100027_00354	COG1309	transcriptional regulator
S100027_00358	COG2310	stress, protein
S100027_00359	COG2310	stress, protein
S100027_00360	COG2310	stress, protein
S100027_00361	COG0861	Integral membrane protein TerC family
S100027_00365	COG3853	Toxic anion resistance protein (TelA)
S100027_00366	COG0785	Cytochrome C biogenesis protein
S100027_00368	COG0789	Transcriptional regulator
S100027_00369	COG2223	nitrite transmembrane transporter activity
S100027_00370	COG0039	L-malate dehydrogenase activity
S100027_00371	COG1620	l-lactate permease
S100027_00372	COG1280	lysine exporter protein (LysE YggA)
S100027_00373	COG1113	amino acid transport
S100027_00374	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S100027_00375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S100027_00376	COG3541	Predicted nucleotidyltransferase
S100027_00377	COG0506	proline dehydrogenase activity
S100027_00378	COG1012	belongs to the aldehyde dehydrogenase family
S100027_00379	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100027_00380	COG2508	Transcriptional regulator
S100027_00381	COG3689	TIGRFAM TIGR03943 family protein
S100027_00382	COG0701	Predicted permease
S100027_00383	COG3458	cephalosporin-C deacetylase activity
S100027_00387	COG0765	amino acid transport
S100027_00388	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100027_00389	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100027_00391	COG2723	6-phospho-beta-galactosidase activity
S100027_00393	COG3209	COG3209 Rhs family protein
S100027_00394	COG3266	domain, Protein
S100027_00394	COG0515	serine threonine protein kinase
S100027_00395	COG3290	protein histidine kinase activity
S100027_00395	COG0840	transmembrane signaling receptor activity
S100027_00396	COG3290	protein histidine kinase activity
S100027_00396	COG0840	transmembrane signaling receptor activity
S100027_00397	COG5444	nuclease activity
S100027_00402	COG1176	ABC-type spermidine putrescine transport system, permease component I
S100027_00404	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100027_00405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100027_00406	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100027_00407	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S100027_00408	COG0697	spore germination
S100027_00409	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100027_00411	COG2819	hydrolase of the alpha beta superfamily
S100027_00413	COG2364	Membrane
S100027_00415	COG1131	(ABC) transporter
S100027_00421	COG1126	abc transporter atp-binding protein
S100027_00422	COG0765	amino acid transport
S100027_00423	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100027_00424	COG3829	transcription factor binding
S100027_00425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S100027_00426	COG0833	amino acid
S100027_00427	COG0010	Belongs to the arginase family
S100027_00428	COG0583	DNA-binding transcription factor activity
S100027_00429	COG0163	prenyltransferase activity
S100027_00430	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S100027_00440	COG5444	nuclease activity
S100027_00444	COG2972	Histidine kinase
S100027_00445	COG4753	response regulator
S100027_00445	COG2207	Transcriptional regulator
S100027_00446	COG4213	ABC transporter substrate-binding protein
S100027_00448	COG4214	carbohydrate transport
S100027_00449	COG2271	Major facilitator Superfamily
S100027_00450	COG1846	Transcriptional regulator
S100027_00450	COG0456	acetyltransferase
S100027_00451	COG1874	Beta-galactosidase
S100027_00452	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
S100027_00453	COG3104	oligopeptide transport
S100027_00454	COG5434	Belongs to the glycosyl hydrolase 28 family
S100027_00456	COG0697	spore germination
S100027_00458	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S100027_00459	COG0789	Transcriptional regulator
S100027_00460	COG1136	(ABC) transporter
S100027_00461	COG0577	efflux transmembrane transporter activity
S100027_00462	COG0745	RESPONSE REGULATOR receiver
S100027_00463	COG5002	protein histidine kinase activity
S100027_00463	COG3850	Histidine kinase
S100027_00464	COG3290	protein histidine kinase activity
S100027_00464	COG0840	transmembrane signaling receptor activity
S100027_00465	COG0840	transmembrane signaling receptor activity
S100027_00466	COG0527	aspartate kinase activity
S100027_00467	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100027_00468	COG4605	iron ion homeostasis
S100027_00469	COG4604	ABC transporter, ATP-binding protein
S100027_00470	COG4607	ABC-type enterochelin transport system periplasmic component
S100027_00471	COG2814	Major facilitator Superfamily
S100027_00472	COG1309	transcriptional regulator
S100027_00474	COG0778	Nitroreductase
S100027_00475	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S100027_00476	COG0640	Transcriptional regulator
S100027_00477	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100027_00478	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S100027_00479	COG0531	amino acid
S100027_00480	COG1012	belongs to the aldehyde dehydrogenase family
S100027_00481	COG0697	spore germination
S100027_00483	COG4549	nuclear export factor GLE1
S100027_00484	COG2372	response to copper ion
S100027_00484	COG1276	copper resistance
S100027_00485	COG1349	DNA-binding transcription factor activity
S100027_00486	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100027_00487	COG0243	molybdopterin cofactor binding
S100027_00488	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100027_00489	COG2146	nitrite reductase [NAD(P)H] activity
S100027_00490	COG1587	Uroporphyrinogen-III synthase
S100027_00490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S100027_00491	COG1802	Transcriptional regulator
S100027_00492	COG0471	metal ion transport
S100027_00493	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100027_00495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100027_00498	COG3959	Transketolase, thiamine diphosphate binding domain
S100027_00499	COG3958	Transketolase
S100027_00500	COG0561	phosphatase activity
S100027_00501	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S100027_00502	COG1914	H( )-stimulated, divalent metal cation uptake system
S100027_00503	COG4336	lyase activity
S100027_00504	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S100027_00505	COG1984	allophanate hydrolase subunit 2
S100027_00506	COG1414	Transcriptional regulator
S100027_00507	COG2755	lipolytic protein G-D-S-L family
S100027_00508	COG2213	PTS system mannitol-specific
S100027_00509	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100027_00510	COG0246	Mannitol dehydrogenase
S100027_00511	COG3711	transcriptional antiterminator
S100027_00512	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_00513	COG1917	Cupin 2, conserved barrel domain protein
S100027_00515	COG3871	stress protein (general stress protein 26)
S100027_00517	COG1316	TRANSCRIPTIONal
S100027_00518	COG2814	Major facilitator Superfamily
S100027_00520	COG1522	sequence-specific DNA binding
S100027_00521	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100027_00521	COG0551	DNA topoisomerase type I activity
S100027_00522	COG0531	amino acid
S100027_00523	COG0531	amino acid
S100027_00524	COG0028	Belongs to the TPP enzyme family
S100027_00525	COG3397	chitin binding
S100027_00527	COG2801	Transposase and inactivated derivatives
S100027_00529	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100027_00530	COG1914	H( )-stimulated, divalent metal cation uptake system
S100027_00531	COG2261	transglycosylase associated protein
S100027_00532	COG1027	Aspartate ammonia-lyase
S100027_00533	COG1819	glycosyl
S100027_00534	COG4876	unkown
S100027_00535	COG2217	Heavy metal translocating P-type atpase
S100027_00537	COG0662	Cupin 2, conserved barrel domain protein
S100027_00538	COG3729	General stress protein
S100027_00539	COG0628	permease
S100027_00540	COG1301	dicarboxylic acid transport
S100027_00541	COG1131	(ABC) transporter
S100027_00542	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100027_00544	COG1960	acyl-CoA dehydrogenase activity
S100027_00547	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100027_00548	COG1181	Belongs to the D-alanine--D-alanine ligase family
S100027_00549	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S100027_00551	COG0513	Belongs to the DEAD box helicase family
S100027_00552	COG3402	PFAM membrane-flanked domain
S100027_00553	COG3428	Bacterial PH domain
S100027_00554	COG0705	Rhomboid family
S100027_00555	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S100027_00556	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S100027_00557	COG0864	Transcriptional regulator
S100027_00558	COG2337	Toxic component of a toxin-antitoxin (TA) module
S100027_00559	COG1366	Belongs to the anti-sigma-factor antagonist family
S100027_00560	COG1366	Belongs to the anti-sigma-factor antagonist family
S100027_00561	COG2172	sigma factor antagonist activity
S100027_00562	COG2208	phosphoserine phosphatase activity
S100027_00564	COG2172	sigma factor antagonist activity
S100027_00565	COG1191	sigma factor activity
S100027_00566	COG2208	phosphoserine phosphatase activity
S100027_00567	COG2183	response to ionizing radiation
S100027_00568	COG1309	transcriptional regulator
S100027_00569	COG1033	growth of symbiont in host cell
S100027_00569	COG2409	Drug exporters of the RND superfamily
S100027_00570	COG3091	SprT-like family
S100027_00579	COG1476	TRANSCRIPTIONal
S100027_00580	COG3239	Fatty acid desaturase
S100027_00581	COG1278	Cold shock
S100027_00582	COG1063	alcohol dehydrogenase
S100027_00584	COG2364	Membrane
S100027_00585	COG1846	Transcriptional regulator
S100027_00586	COG0456	acetyltransferase
S100027_00587	COG2808	Putative FMN-binding domain
S100027_00589	COG1733	regulation of RNA biosynthetic process
S100027_00590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100027_00592	COG0583	DNA-binding transcription factor activity
S100027_00595	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
S100027_00596	COG1113	amino acid transport
S100027_00599	COG1595	DNA-templated transcription, initiation
S100027_00601	COG2755	lipolytic protein G-D-S-L family
S100027_00601	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S100027_00602	COG2814	Major facilitator Superfamily
S100027_00603	COG2972	Histidine kinase
S100027_00603	COG0745	RESPONSE REGULATOR receiver
S100027_00604	COG3279	Response regulator of the LytR AlgR family
S100027_00606	COG3764	Sortase (surface protein transpeptidase)
S100027_00607	COG2814	Major facilitator Superfamily
S100027_00615	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S100027_00616	COG0802	atpase or kinase
S100027_00617	COG1214	PFAM Peptidase M22, glycoprotease
S100027_00618	COG0456	acetyltransferase
S100027_00619	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S100027_00620	COG0488	(ABC) transporter
S100027_00621	COG0315	cyclic pyranopterin monophosphate synthase activity
S100027_00622	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S100027_00623	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100027_00624	COG0805	protein transport
S100027_00626	COG1266	CAAX protease self-immunity
S100027_00627	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S100027_00628	COG0459	protein refolding
S100027_00629	COG4974	Belongs to the 'phage' integrase family
S100027_00630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S100027_00652	COG0582	viral genome integration into host DNA
S100027_00659	COG4626	Terminase
S100027_00659	COG1802	Transcriptional regulator
S100027_00674	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100027_00683	COG5444	nuclease activity
S100027_00691	COG2720	vancomycin resistance protein
S100027_00694	COG2135	peptidase activity
S100027_00695	COG1309	transcriptional regulator
S100027_00696	COG3848	Pyruvate phosphate dikinase
S100027_00696	COG0574	Belongs to the PEP-utilizing enzyme family
S100027_00698	COG3189	MarR family transcriptional regulator
S100027_00699	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
S100027_00700	COG2272	Belongs to the type-B carboxylesterase lipase family
S100027_00701	COG2814	Major facilitator Superfamily
S100027_00702	COG1842	Phage shock protein A
S100027_00703	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100027_00704	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
S100027_00705	COG4260	virion core protein, lumpy skin disease virus
S100027_00707	COG1378	Sugar-specific transcriptional regulator TrmB
S100027_00708	COG1280	lysine exporter protein (LysE YggA)
S100027_00709	COG3339	Conserved Protein
S100027_00710	COG0772	Belongs to the SEDS family
S100027_00711	COG0772	Belongs to the SEDS family
S100027_00715	COG0726	polysaccharide deacetylase
S100027_00717	COG1609	Transcriptional regulator
S100027_00718	COG0366	Alpha amylase catalytic
S100027_00719	COG2182	Extracellular solute-binding protein
S100027_00720	COG1175	transmembrane transport
S100027_00721	COG3833	ABC-type maltose transport systems, permease component
S100027_00722	COG5521	maltodextrose utilization protein MalA
S100027_00723	COG1554	hydrolase, family 65, central catalytic
S100027_00724	COG0366	Alpha amylase catalytic
S100027_00725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100027_00726	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100027_00727	COG1846	Transcriptional regulator
S100027_00730	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S100027_00731	COG0823	Involved in the tonB-independent uptake of proteins
S100027_00737	COG0702	epimerase
S100027_00739	COG2132	Multicopper oxidase
S100027_00742	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100027_00743	COG0714	Associated with various cellular activities
S100027_00744	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
S100027_00745	COG1305	Transglutaminase-like
S100027_00746	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S100027_00746	COG0519	Catalyzes the synthesis of GMP from XMP
S100027_00747	COG2252	PERMEase
S100027_00750	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
S100027_00752	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S100027_00753	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S100027_00754	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S100027_00755	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S100027_00756	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100027_00757	COG0047	phosphoribosylformylglycinamidine synthase activity
S100027_00758	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100027_00759	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S100027_00760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S100027_00761	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S100027_00762	COG0138	bifunctional purine biosynthesis protein purh
S100027_00763	COG0151	Belongs to the GarS family
S100027_00765	COG2124	cytochrome p450
S100027_00770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100027_00771	COG1470	cell adhesion involved in biofilm formation
S100027_00772	COG4496	protein, YerC YecD
S100027_00773	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
S100027_00774	COG0210	DNA helicase
S100027_00775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S100027_00776	COG4851	CamS sex pheromone cAM373 precursor
S100027_00777	COG2188	Transcriptional regulator
S100027_00781	COG1735	metal-dependent hydrolase with the TIM-barrel fold
S100027_00782	COG0626	cystathionine gamma-synthase activity
S100027_00783	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S100027_00784	COG3457	Alanine racemase
S100027_00785	COG0363	glucosamine-6-phosphate deaminase activity
S100027_00786	COG1285	pathogenesis
S100027_00787	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100027_00788	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100027_00789	COG0154	amidase activity
S100027_00790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100027_00793	COG4124	Belongs to the glycosyl hydrolase 26 family
S100027_00794	COG1309	transcriptional regulator
S100027_00795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S100027_00797	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100027_00799	COG1597	lipid kinase activity
S100027_00800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100027_00801	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S100027_00802	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S100027_00808	COG3645	SOS response
S100027_00810	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
S100027_00816	COG2801	Transposase and inactivated derivatives
S100027_00817	COG2190	(PTS) system
S100027_00817	COG1263	PTS System
S100027_00817	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_00818	COG2723	6-phospho-beta-galactosidase activity
S100027_00819	COG3711	transcriptional antiterminator
S100027_00820	COG0457	Tetratricopeptide repeat
S100027_00823	COG0217	transcriptional regulatory protein
S100027_00826	COG1012	belongs to the aldehyde dehydrogenase family
S100027_00827	COG0840	transmembrane signaling receptor activity
S100027_00828	COG0471	metal ion transport
S100027_00829	COG0488	(ABC) transporter
S100027_00830	COG1469	GTP cyclohydrolase I activity
S100027_00833	COG0523	cobalamin synthesis protein
S100027_00834	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
S100027_00835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100027_00836	COG0156	8-amino-7-oxononanoate synthase activity
S100027_00837	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
S100027_00838	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S100027_00839	COG2124	cytochrome p450
S100027_00841	COG0789	Transcriptional regulator
S100027_00842	COG2814	Major facilitator Superfamily
S100027_00843	COG0488	(ABC) transporter
S100027_00844	COG0513	Belongs to the DEAD box helicase family
S100027_00845	COG2130	NADP-dependent
S100027_00848	COG0471	metal ion transport
S100027_00851	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100027_00853	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
S100027_00854	COG5658	integral membrane protein
S100027_00855	COG0640	Transcriptional regulator
S100027_00856	COG1254	Belongs to the acylphosphatase family
S100027_00857	COG2258	MOSC domain
S100027_00860	COG0024	Methionine aminopeptidase
S100027_00861	COG1368	sulfuric ester hydrolase activity
S100027_00863	COG1115	amino acid carrier protein
S100027_00864	COG1263	PTS System
S100027_00864	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_00865	COG0366	Alpha amylase catalytic
S100027_00866	COG2188	Transcriptional regulator
S100027_00870	COG2801	Transposase and inactivated derivatives
S100027_00872	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100027_00873	COG1045	serine acetyltransferase
S100027_00874	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100027_00876	COG1215	transferase activity, transferring glycosyl groups
S100027_00877	COG0457	Tetratricopeptide repeat
S100027_00877	COG0463	Glycosyl transferase, family 2
S100027_00879	COG0673	inositol 2-dehydrogenase activity
S100027_00882	COG1733	regulation of RNA biosynthetic process
S100027_00883	COG0778	Nitroreductase
S100027_00884	COG0737	Belongs to the 5'-nucleotidase family
S100027_00885	COG0693	protein deglycase activity
S100027_00886	COG4840	Belongs to the UPF0435 family
S100027_00887	COG1115	amino acid carrier protein
S100027_00888	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100027_00889	COG4980	gas vesicle protein
S100027_00890	COG1295	ribonuclease BN
S100027_00892	COG0477	Major facilitator Superfamily
S100027_00894	COG0387	Pfam Sodium calcium exchanger
S100027_00896	COG0535	radical SAM domain protein
S100027_00898	COG0726	polysaccharide deacetylase
S100027_00899	COG0371	Dehydrogenase
S100027_00901	COG0598	Magnesium transport protein CorA
S100027_00902	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S100027_00903	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100027_00904	COG4637	Psort location Cytoplasmic, score
S100027_00909	COG1819	glycosyl
S100027_00911	COG0477	Major facilitator Superfamily
S100027_00912	COG1263	PTS System
S100027_00912	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_00913	COG3711	transcriptional antiterminator
S100027_00914	COG0288	reversible hydration of carbon dioxide
S100027_00915	COG3002	Belongs to the UPF0753 family
S100027_00916	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S100027_00917	COG5609	conserved protein (DUF2294)
S100027_00919	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100027_00920	COG0022	dehydrogenase e1 component
S100027_00921	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100027_00922	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100027_00923	COG3284	Transcriptional regulator
S100027_00924	COG1742	UPF0060 membrane protein
S100027_00925	COG1486	melibiose metabolic process
S100027_00926	COG1737	Transcriptional regulator
S100027_00927	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_00927	COG1263	PTS System
S100027_00930	COG1733	regulation of RNA biosynthetic process
S100027_00931	COG2259	Doxx family
S100027_00932	COG2514	catechol 2,3-dioxygenase activity
S100027_00934	COG3507	Belongs to the glycosyl hydrolase 43 family
S100027_00935	COG1917	Cupin 2, conserved barrel domain protein
S100027_00935	COG2207	Transcriptional regulator
S100027_00936	COG1653	transport
S100027_00937	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100027_00938	COG1051	belongs to the nudix hydrolase family
S100027_00940	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S100027_00940	COG0392	lysyltransferase activity
S100027_00942	COG0384	phenazine biosynthesis protein PhzF
S100027_00943	COG0778	Nitroreductase
S100027_00947	COG1090	epimerase
S100027_00948	COG2137	regulation of response to DNA damage stimulus
S100027_00953	COG0463	Glycosyl transferase, family 2
S100027_00955	COG4485	Bacterial membrane protein, YfhO
S100027_00956	COG1988	membrane-bound metal-dependent
S100027_00957	COG1194	a g-specific adenine glycosylase
S100027_00959	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_00962	COG3557	Belongs to the UPF0374 family
S100027_00963	COG1132	(ABC) transporter
S100027_00964	COG0444	Belongs to the ABC transporter superfamily
S100027_00965	COG4608	Belongs to the ABC transporter superfamily
S100027_00966	COG0747	negative chemotaxis
S100027_00969	COG4129	membrane
S100027_00970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S100027_00971	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S100027_00972	COG0735	belongs to the Fur family
S100027_00993	COG4974	Belongs to the 'phage' integrase family
S100027_01021	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100027_01021	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100027_01024	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
S100027_01030	COG1780	Probably involved in ribonucleotide reductase function
S100027_01031	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100027_01033	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100027_01034	COG0756	dUTP diphosphatase activity
S100027_01037	COG3584	3D domain protein
S100027_01059	COG0740	serine-type endopeptidase activity
S100027_01069	COG5280	Phage tail tape measure protein TP901
S100027_01069	COG3953	SLT domain
S100027_01078	COG3409	Peptidoglycan-binding domain 1 protein
S100027_01078	COG1388	LysM domain
S100027_01078	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100027_01082	COG0438	transferase activity, transferring glycosyl groups
S100027_01087	COG0457	Tetratricopeptide repeat
S100027_01093	COG5444	nuclease activity
S100027_01097	COG5444	nuclease activity
S100027_01098	COG0457	Tetratricopeptide repeat
S100027_01100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100027_01101	COG0710	3-dehydroquinate dehydratase activity
S100027_01102	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S100027_01103	COG1116	anion transmembrane transporter activity
S100027_01104	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S100027_01105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S100027_01106	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100027_01108	COG1476	TRANSCRIPTIONal
S100027_01110	COG1131	(ABC) transporter
S100027_01114	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100027_01116	COG3382	B3 4 domain protein
S100027_01117	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S100027_01119	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S100027_01120	COG0789	Transcriptional regulator
S100027_01121	COG1664	Polymer-forming cytoskeletal
S100027_01123	COG2766	serine protein kinase
S100027_01124	COG2718	Belongs to the UPF0229 family
S100027_01125	COG1566	PFAM secretion protein HlyD family protein
S100027_01126	COG2814	Major facilitator Superfamily
S100027_01127	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100027_01129	COG1131	(ABC) transporter
S100027_01130	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100027_01131	COG2801	Transposase and inactivated derivatives
S100027_01133	COG1278	Cold shock
S100027_01134	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S100027_01135	COG2011	ABC-type metal ion transport system permease component
S100027_01136	COG1464	Belongs to the NlpA lipoprotein family
S100027_01137	COG1823	symporter activity
S100027_01142	COG5577	PFAM Coat F domain
S100027_01143	COG5002	protein histidine kinase activity
S100027_01144	COG4085	toxin activity
S100027_01144	COG0737	Belongs to the 5'-nucleotidase family
S100027_01144	COG1525	nuclease
S100027_01145	COG3764	Sortase (surface protein transpeptidase)
S100027_01146	COG0564	pseudouridine synthase activity
S100027_01148	COG0517	IMP dehydrogenase activity
S100027_01149	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100027_01150	COG3153	acetyltransferase
S100027_01150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S100027_01152	COG0488	(ABC) transporter
S100027_01153	COG2116	formate transmembrane transporter activity
S100027_01154	COG0679	Auxin Efflux Carrier
S100027_01155	COG0604	alcohol dehydrogenase
S100027_01156	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
S100027_01157	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100027_01158	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S100027_01160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S100027_01161	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100027_01164	COG4585	Histidine kinase
S100027_01164	COG2203	Gaf domain
S100027_01165	COG2197	response regulator
S100027_01166	COG0431	NADPH-dependent FMN reductase
S100027_01169	COG1959	2 iron, 2 sulfur cluster binding
S100027_01170	COG1017	nitric oxide dioxygenase activity
S100027_01170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S100027_01171	COG2719	SpoVR family
S100027_01172	COG1388	LysM domain
S100027_01172	COG0791	NLP P60 protein
S100027_01173	COG0583	DNA-binding transcription factor activity
S100027_01174	COG0372	Belongs to the citrate synthase family
S100027_01175	COG2133	pyrroloquinoline quinone binding
S100027_01176	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_01177	COG0733	neurotransmitter:sodium symporter activity
S100027_01179	COG2207	Transcriptional regulator
S100027_01179	COG3708	Transcriptional regulator
S100027_01180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100027_01184	COG1595	DNA-templated transcription, initiation
S100027_01185	COG0662	Cupin 2, conserved barrel domain protein
S100027_01187	COG0204	Acyl-transferase
S100027_01189	COG3152	Membrane
S100027_01191	COG1309	transcriptional regulator
S100027_01192	COG1253	flavin adenine dinucleotide binding
S100027_01193	COG0789	Transcriptional regulator
S100027_01195	COG1253	flavin adenine dinucleotide binding
S100027_01199	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100027_01200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100027_01201	COG0584	glycerophosphoryl diester phosphodiesterase
S100027_01203	COG0668	transmembrane transport
S100027_01204	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S100027_01207	COG0726	polysaccharide deacetylase
S100027_01209	COG1757	Na H antiporter
S100027_01210	COG2017	converts alpha-aldose to the beta-anomer
S100027_01214	COG0589	response to stress
S100027_01215	COG1132	(ABC) transporter
S100027_01216	COG1132	(ABC) transporter
S100027_01217	COG0702	epimerase
S100027_01221	COG3842	ATPase activity
S100027_01222	COG2508	Transcriptional regulator
S100027_01224	COG0189	ligase activity
S100027_01225	COG0189	ligase activity
S100027_01226	COG4399	Belongs to the UPF0754 family
S100027_01227	COG3679	Belongs to the UPF0342 family
S100027_01228	COG0561	phosphatase activity
S100027_01229	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S100027_01230	COG0475	glutathione-regulated potassium exporter activity
S100027_01231	COG0490	domain, Protein
S100027_01233	COG1024	Enoyl-CoA hydratase
S100027_01234	COG0457	Tetratricopeptide repeat
S100027_01238	COG4152	abc transporter atp-binding protein
S100027_01239	COG1668	transmembrane transport
S100027_01240	COG0420	3'-5' exonuclease activity
S100027_01241	COG4717	serine-type aminopeptidase activity
S100027_01242	COG3481	metal-dependent phosphohydrolase, HD sub domain
S100027_01244	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100027_01248	COG1846	Transcriptional regulator
S100027_01249	COG4980	gas vesicle protein
S100027_01252	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S100027_01253	COG0537	adenosine 5'-monophosphoramidase activity
S100027_01254	COG1131	(ABC) transporter
S100027_01255	COG4473	ABC transporter
S100027_01257	COG1473	amidohydrolase
S100027_01258	COG3069	C4-dicarboxylate transmembrane transporter activity
S100027_01259	COG2329	Antibiotic biosynthesis monooxygenase
S100027_01260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100027_01261	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S100027_01264	COG1309	transcriptional regulator
S100027_01265	COG1511	domain protein
S100027_01266	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100027_01267	COG1363	Peptidase, m42
S100027_01269	COG1301	dicarboxylic acid transport
S100027_01271	COG1234	tRNA 3'-trailer cleavage
S100027_01272	COG0095	Lipoate-protein ligase
S100027_01273	COG0318	PFAM AMP-dependent synthetase and ligase
S100027_01275	COG1396	sequence-specific DNA binding
S100027_01278	COG0501	Belongs to the peptidase M48B family
S100027_01280	COG0697	spore germination
S100027_01281	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S100027_01282	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100027_01283	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100027_01284	COG0406	alpha-ribazole phosphatase activity
S100027_01285	COG0840	transmembrane signaling receptor activity
S100027_01286	COG0723	plastoquinol--plastocyanin reductase activity
S100027_01286	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100027_01287	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_01289	COG4903	ComK protein
S100027_01291	COG0398	Pfam SNARE associated Golgi protein
S100027_01292	COG0681	Belongs to the peptidase S26 family
S100027_01293	COG1404	Belongs to the peptidase S8 family
S100027_01295	COG2508	Transcriptional regulator
S100027_01297	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100027_01298	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100027_01299	COG3257	ureidoglycine aminohydrolase activity
S100027_01300	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S100027_01301	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S100027_01302	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S100027_01303	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S100027_01304	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S100027_01306	COG0549	Belongs to the carbamate kinase family
S100027_01307	COG2814	Major facilitator Superfamily
S100027_01309	COG0457	Tetratricopeptide repeat
S100027_01317	COG1486	melibiose metabolic process
S100027_01318	COG3180	Ammonia monooxygenase
S100027_01321	COG3546	catalase activity
S100027_01322	COG0318	PFAM AMP-dependent synthetase and ligase
S100027_01323	COG0477	Major facilitator Superfamily
S100027_01323	COG2814	Major facilitator Superfamily
S100027_01325	COG5002	protein histidine kinase activity
S100027_01326	COG0745	RESPONSE REGULATOR receiver
S100027_01327	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S100027_01328	COG0725	ABC transporter, periplasmic molybdate-binding protein
S100027_01329	COG4149	molybdate abc transporter
S100027_01330	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S100027_01331	COG1074	ATP-dependent DNA helicase activity
S100027_01332	COG0420	3'-5' exonuclease activity
S100027_01333	COG0419	ATPase involved in DNA repair
S100027_01342	COG5337	Spore coat protein CotH
S100027_01344	COG0179	Fumarylacetoacetate (FAA) hydrolase
S100027_01349	COG0367	asparagine synthase
S100027_01350	COG0004	ammonium transporteR
S100027_01351	COG0004	ammonium transporteR
S100027_01352	COG0347	Belongs to the P(II) protein family
S100027_01353	COG0534	Mate efflux family protein
S100027_01354	COG2207	Transcriptional regulator
S100027_01354	COG1917	Cupin 2, conserved barrel domain protein
S100027_01356	COG1609	Transcriptional regulator
S100027_01357	COG0673	inositol 2-dehydrogenase activity
S100027_01358	COG0673	inositol 2-dehydrogenase activity
S100027_01359	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100027_01361	COG0076	glutamate decarboxylase activity
S100027_01366	COG2153	protein acetylation
S100027_01367	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_01368	COG2378	regulation of single-species biofilm formation
S100027_01369	COG0646	methionine synthase
S100027_01369	COG1410	methionine synthase
S100027_01370	COG0646	methionine synthase
S100027_01370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S100027_01371	COG1666	GTP binding
S100027_01372	COG2996	Protein conserved in bacteria
S100027_01375	COG1307	EDD domain protein, DegV family
S100027_01376	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100027_01378	COG0516	GMP reductase activity
S100027_01380	COG0561	phosphatase activity
S100027_01381	COG1073	alpha beta
S100027_01382	COG2151	metal-sulfur cluster biosynthetic enzyme
S100027_01383	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S100027_01384	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S100027_01385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S100027_01386	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S100027_01387	COG0505	Belongs to the CarA family
S100027_01388	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100027_01389	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S100027_01390	COG1968	undecaprenyl-diphosphatase activity
S100027_01393	COG2267	carboxylic ester hydrolase activity
S100027_01395	COG1744	ABC transporter substrate-binding protein PnrA-like
S100027_01398	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100027_01399	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S100027_01400	COG5504	Zn-dependent protease
S100027_01401	COG0444	Belongs to the ABC transporter superfamily
S100027_01402	COG4608	Belongs to the ABC transporter superfamily
S100027_01404	COG0601	transmembrane transport
S100027_01405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100027_01410	COG0180	Tryptophanyl-tRNA synthetase
S100027_01411	COG4166	transmembrane transport
S100027_01412	COG0601	transmembrane transport
S100027_01413	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100027_01414	COG0444	Belongs to the ABC transporter superfamily
S100027_01415	COG4608	Belongs to the ABC transporter superfamily
S100027_01416	COG0456	acetyltransferase
S100027_01417	COG1393	Belongs to the ArsC family
S100027_01418	COG0861	Integral membrane protein TerC family
S100027_01419	COG4862	establishment of competence for transformation
S100027_01423	COG4565	transcriptional regulatory protein
S100027_01424	COG3290	protein histidine kinase activity
S100027_01425	COG4469	Competence protein
S100027_01426	COG1164	Oligoendopeptidase f
S100027_01429	COG2346	COG2346, Truncated hemoglobins
S100027_01430	COG0741	lytic transglycosylase activity
S100027_01431	COG4116	CYTH
S100027_01433	COG2357	RelA SpoT domain protein
S100027_01434	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100027_01435	COG0564	pseudouridine synthase activity
S100027_01436	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S100027_01437	COG0475	glutathione-regulated potassium exporter activity
S100027_01437	COG0569	domain protein
S100027_01438	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S100027_01439	COG0352	thiamine-phosphate diphosphorylase activity
S100027_01441	COG2104	thiamine diphosphate biosynthetic process
S100027_01442	COG2022	thiamine diphosphate biosynthetic process
S100027_01443	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100027_01444	COG0351	phosphomethylpyrimidine kinase
S100027_01445	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S100027_01456	COG0210	DNA helicase
S100027_01458	COG0586	Pfam SNARE associated Golgi protein
S100027_01459	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100027_01460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100027_01461	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100027_01462	COG2246	polysaccharide biosynthetic process
S100027_01463	COG2153	protein acetylation
S100027_01464	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S100027_01465	COG2382	esterase
S100027_01468	COG0626	cystathionine gamma-synthase activity
S100027_01469	COG0626	cystathionine gamma-synthase activity
S100027_01470	COG5505	Protein of unknown function (DUF819)
S100027_01473	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100027_01474	COG3507	Belongs to the glycosyl hydrolase 43 family
S100027_01477	COG0110	maltose O-acetyltransferase activity
S100027_01479	COG0583	DNA-binding transcription factor activity
S100027_01480	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100027_01481	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100027_01482	COG0583	DNA-binding transcription factor activity
S100027_01483	COG0697	spore germination
S100027_01484	COG0346	lactoylglutathione lyase activity
S100027_01486	COG1388	LysM domain
S100027_01486	COG3584	3D domain protein
S100027_01487	COG2814	Major facilitator Superfamily
S100027_01488	COG1309	transcriptional regulator
S100027_01491	COG5444	nuclease activity
S100027_01492	COG5444	nuclease activity
S100027_01493	COG4195	phage-related replication protein
S100027_01494	COG2856	Zn peptidase
S100027_01495	COG1396	sequence-specific DNA binding
S100027_01498	COG1522	sequence-specific DNA binding
S100027_01499	COG1484	DNA-dependent DNA replication
S100027_01503	COG1595	DNA-templated transcription, initiation
S100027_01504	COG3728	DNA packaging
S100027_01504	COG5484	DNA packaging
S100027_01505	COG1783	phage Terminase large subunit
S100027_01506	COG5518	Phage portal protein
S100027_01507	COG0338	D12 class N6 adenine-specific DNA methyltransferase
S100027_01508	COG4653	Phage capsid family
S100027_01518	COG3953	SLT domain
S100027_01518	COG5412	phage tail tape measure protein
S100027_01519	COG1652	LysM domain
S100027_01520	COG4193	domain, Protein
S100027_01522	COG3628	GPW Gp25 family protein
S100027_01523	COG3299	homolog of phage Mu protein gp47
S100027_01524	COG3778	Protein conserved in bacteria
S100027_01532	COG1802	Transcriptional regulator
S100027_01533	COG1063	alcohol dehydrogenase
S100027_01534	COG1312	Catalyzes the dehydration of D-mannonate
S100027_01535	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_01536	COG1063	alcohol dehydrogenase
S100027_01537	COG2271	Major facilitator Superfamily
S100027_01540	COG0306	phosphate transporter
S100027_01541	COG1392	Phosphate transport regulator
S100027_01542	COG0405	Gamma-glutamyltransferase
S100027_01543	COG5578	integral membrane protein
S100027_01544	COG5578	integral membrane protein
S100027_01545	COG2972	Histidine kinase
S100027_01546	COG2207	Transcriptional regulator
S100027_01546	COG4753	response regulator
S100027_01547	COG1653	transport
S100027_01548	COG1175	transmembrane transport
S100027_01549	COG0395	ABC-type sugar transport system, permease component
S100027_01550	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S100027_01551	COG2207	Transcriptional regulator
S100027_01552	COG2755	lipolytic protein G-D-S-L family
S100027_01554	COG5578	integral membrane protein
S100027_01555	COG3401	FG-GAP repeat protein
S100027_01557	COG2755	lipolytic protein G-D-S-L family
S100027_01558	COG3401	FG-GAP repeat protein
S100027_01559	COG0667	Aldo Keto reductase
S100027_01560	COG2755	lipolytic protein G-D-S-L family
S100027_01561	COG1874	Beta-galactosidase
S100027_01563	COG1653	transport
S100027_01564	COG4209	transmembrane transport
S100027_01565	COG0395	ABC-type sugar transport system, permease component
S100027_01566	COG0531	amino acid
S100027_01567	COG0346	lactoylglutathione lyase activity
S100027_01569	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100027_01570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100027_01571	COG2362	D-Aminopeptidase
S100027_01572	COG0601	transmembrane transport
S100027_01573	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100027_01574	COG0444	Belongs to the ABC transporter superfamily
S100027_01575	COG4166	transmembrane transport
S100027_01576	COG1619	proteins homologs of microcin C7 resistance protein MccF
S100027_01577	COG4948	Mandelate Racemase Muconate Lactonizing
S100027_01578	COG0791	NLP P60 protein
S100027_01579	COG4608	Belongs to the ABC transporter superfamily
S100027_01580	COG1834	amidinotransferase
S100027_01581	COG1607	acyl-coa hydrolase
S100027_01582	COG2323	membrane
S100027_01583	COG3866	Pectate lyase
S100027_01588	COG2318	DinB family
S100027_01589	COG2076	Multidrug Resistance protein
S100027_01590	COG2076	Multidrug Resistance protein
S100027_01591	COG0788	formyltetrahydrofolate deformylase activity
S100027_01592	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S100027_01593	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S100027_01594	COG1764	response to oxidative stress
S100027_01596	COG1846	Transcriptional regulator
S100027_01597	COG1764	response to oxidative stress
S100027_01599	COG0590	tRNA wobble adenosine to inosine editing
S100027_01600	COG0406	alpha-ribazole phosphatase activity
S100027_01603	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100027_01604	COG1404	Belongs to the peptidase S8 family
S100027_01606	COG2239	Acts as a magnesium transporter
S100027_01608	COG0789	Transcriptional regulator
S100027_01612	COG1846	Transcriptional regulator
S100027_01613	COG3285	dna ligase
S100027_01613	COG1793	dna ligase
S100027_01614	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S100027_01615	COG5001	Diguanylate cyclase
S100027_01615	COG3300	MHYT domain
S100027_01616	COG0586	Pfam SNARE associated Golgi protein
S100027_01617	COG0861	Integral membrane protein TerC family
S100027_01618	COG1191	sigma factor activity
S100027_01622	COG0501	Belongs to the peptidase M48B family
S100027_01623	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100027_01624	COG0768	penicillin binding
S100027_01627	COG3594	Acyltransferase
S100027_01628	COG5002	protein histidine kinase activity
S100027_01629	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100027_01631	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S100027_01632	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
S100027_01633	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S100027_01634	COG0436	Aminotransferase
S100027_01635	COG1850	ribulose-bisphosphate carboxylase activity
S100027_01636	COG0235	Class ii aldolase
S100027_01636	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
S100027_01637	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S100027_01638	COG0346	lactoylglutathione lyase activity
S100027_01639	COG3339	Conserved Protein
S100027_01641	COG3852	Histidine kinase
S100027_01642	COG1846	Transcriptional regulator
S100027_01643	COG1360	Flagellar Motor Protein
S100027_01644	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S100027_01645	COG0542	response to heat
S100027_01646	COG3949	Membrane
S100027_01647	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S100027_01648	COG0720	synthase
S100027_01649	COG0602	queuosine metabolic process
S100027_01650	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S100027_01653	COG0457	Tetratricopeptide repeat
S100027_01654	COG0457	Tetratricopeptide repeat
S100027_01655	COG3739	integral membrane protein
S100027_01656	COG3655	Transcriptional regulator
S100027_01661	COG2801	Transposase and inactivated derivatives
S100027_01665	COG4873	Protein conserved in bacteria
S100027_01667	COG3773	Cell wall hydrolase
S100027_01668	COG2244	polysaccharide biosynthetic process
S100027_01669	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100027_01670	COG2217	Heavy metal translocating P-type atpase
S100027_01671	COG0006	proline dipeptidase activity
S100027_01674	COG1609	Transcriptional regulator
S100027_01675	COG3711	transcriptional antiterminator
S100027_01676	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_01676	COG1263	PTS System
S100027_01676	COG2190	(PTS) system
S100027_01677	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100027_01678	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S100027_01680	COG1533	DNA photolyase activity
S100027_01681	COG0456	acetyltransferase
S100027_01682	COG0840	transmembrane signaling receptor activity
S100027_01683	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_01684	COG2084	Dehydrogenase
S100027_01685	COG2340	Cysteine-rich secretory protein family
S100027_01686	COG0768	penicillin binding
S100027_01687	COG4191	Histidine kinase
S100027_01688	COG0436	Aminotransferase
S100027_01690	COG1714	RDD family
S100027_01692	COG0835	chemotaxis
S100027_01692	COG0784	Response regulator, receiver
S100027_01694	COG2814	Major facilitator Superfamily
S100027_01695	COG1376	ErfK ybiS ycfS ynhG family protein
S100027_01696	COG1408	metallophosphoesterase
S100027_01697	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_01698	COG2200	EAL domain
S100027_01700	COG4703	Protein of unknown function (DUF1797)
S100027_01702	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
S100027_01704	COG0517	IMP dehydrogenase activity
S100027_01705	COG0583	DNA-binding transcription factor activity
S100027_01706	COG0716	FMN binding
S100027_01708	COG0716	FMN binding
S100027_01709	COG2171	N-acyltransferase activity
S100027_01710	COG1473	amidohydrolase
S100027_01712	COG0450	alkyl hydroperoxide reductase
S100027_01713	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100027_01716	COG0746	molybdenum cofactor guanylyltransferase activity
S100027_01717	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100027_01718	COG0303	'Molybdopterin
S100027_01719	COG1763	Mo-molybdopterin cofactor biosynthetic process
S100027_01720	COG0314	molybdopterin synthase activity
S100027_01721	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S100027_01723	COG1132	(ABC) transporter
S100027_01724	COG1132	(ABC) transporter
S100027_01726	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S100027_01727	COG1136	(ABC) transporter
S100027_01728	COG0577	efflux transmembrane transporter activity
S100027_01729	COG1349	DNA-binding transcription factor activity
S100027_01730	COG1105	Belongs to the carbohydrate kinase PfkB family
S100027_01731	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100027_01731	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100027_01731	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100027_01735	COG0488	(ABC) transporter
S100027_01737	COG2309	aminopeptidase activity
S100027_01739	COG1077	Cell shape determining protein MreB Mrl
S100027_01740	COG2002	toxin-antitoxin pair type II binding
S100027_01741	COG3852	Histidine kinase
S100027_01742	COG0569	domain protein
S100027_01743	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100027_01744	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S100027_01746	COG0561	phosphatase activity
S100027_01748	COG0242	peptide deformylase activity
S100027_01750	COG0497	DNA recombination
S100027_01751	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100027_01752	COG0022	dehydrogenase e1 component
S100027_01753	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100027_01754	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100027_01756	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100027_01758	COG1982	Orn Lys Arg decarboxylase major
S100027_01759	COG4476	Belongs to the UPF0223 family
S100027_01760	COG4493	Belongs to the UPF0637 family
S100027_01762	COG0483	inositol monophosphate 1-phosphatase activity
S100027_01766	COG1595	DNA-templated transcription, initiation
S100027_01771	COG1846	Transcriptional regulator
S100027_01772	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S100027_01773	COG4896	Protein conserved in bacteria
S100027_01775	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S100027_01776	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S100027_01777	COG2066	Belongs to the glutaminase family
S100027_01778	COG4838	Belongs to the UPF0358 family
S100027_01779	COG0772	Belongs to the SEDS family
S100027_01780	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S100027_01781	COG1612	heme a metabolic process
S100027_01782	COG0109	protoheme IX farnesyltransferase activity
S100027_01783	COG2010	Cytochrome c
S100027_01783	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S100027_01784	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S100027_01785	COG1845	cytochrome c oxidase, subunit III
S100027_01786	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S100027_01787	COG3336	cytochrome c oxidase
S100027_01789	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S100027_01790	COG2340	Cysteine-rich secretory protein family
S100027_01794	COG3679	Belongs to the UPF0342 family
S100027_01795	COG4471	UPF0298 protein
S100027_01797	COG0742	ribosomal rna small subunit methyltransferase
S100027_01798	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S100027_01799	COG3314	Sporulation integral membrane protein YlbJ
S100027_01800	COG3480	Lon protease (S16) C-terminal proteolytic domain
S100027_01801	COG1323	Belongs to the UPF0348 family
S100027_01802	COG1399	metal-binding, possibly nucleic acid-binding protein
S100027_01803	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S100027_01805	COG0454	-acetyltransferase
S100027_01806	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S100027_01807	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
S100027_01808	COG2001	Belongs to the MraZ family
S100027_01809	COG0275	rRNA processing
S100027_01810	COG4839	cell division protein FtsL
S100027_01812	COG0768	penicillin binding
S100027_01814	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S100027_01815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100027_01816	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100027_01817	COG0772	Belongs to the SEDS family
S100027_01818	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100027_01819	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S100027_01820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S100027_01821	COG3879	Bacterial protein of unknown function (DUF881)
S100027_01822	COG3879	Bacterial protein of unknown function (DUF881)
S100027_01823	COG3856	small basic protein
S100027_01824	COG0849	cell division
S100027_01825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S100027_01826	COG1404	Belongs to the peptidase S8 family
S100027_01826	COG4412	M6 family metalloprotease domain protein
S100027_01828	COG4412	M6 family metalloprotease domain protein
S100027_01828	COG1404	Belongs to the peptidase S8 family
S100027_01829	COG1404	Belongs to the peptidase S8 family
S100027_01829	COG4412	M6 family metalloprotease domain protein
S100027_01831	COG1191	sigma factor activity
S100027_01832	COG1191	sigma factor activity
S100027_01833	COG1119	ATPase activity
S100027_01834	COG0500	methyltransferase
S100027_01835	COG1873	PFAM PRC-barrel domain
S100027_01837	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
S100027_01838	COG1799	cell septum assembly
S100027_01839	COG0762	integral membrane protein
S100027_01840	COG2302	S4 RNA-binding domain
S100027_01841	COG3599	regulation of cell shape
S100027_01842	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S100027_01843	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100027_01844	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S100027_01845	COG0564	pseudouridine synthase activity
S100027_01846	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S100027_01847	COG2233	PERMEase
S100027_01848	COG0540	Belongs to the ATCase OTCase family
S100027_01849	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100027_01850	COG0505	Belongs to the CarA family
S100027_01851	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100027_01852	COG0543	2 iron, 2 sulfur cluster binding
S100027_01853	COG0167	dihydroorotate dehydrogenase activity
S100027_01854	COG0284	orotidine-5'-phosphate decarboxylase activity
S100027_01855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S100027_01857	COG0175	sulfate reduction
S100027_01858	COG0306	phosphate transporter
S100027_01859	COG2046	Belongs to the sulfate adenylyltransferase family
S100027_01860	COG0529	Catalyzes the synthesis of activated sulfate
S100027_01861	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S100027_01862	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
S100027_01863	COG1648	precorrin-2 dehydrogenase activity
S100027_01865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S100027_01866	COG1561	YicC-like family, N-terminal region
S100027_01867	COG2052	Domain of unknown function (DUF370)
S100027_01868	COG0194	GDP metabolic process
S100027_01869	COG1758	RNA polymerase activity
S100027_01870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100027_01871	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100027_01872	COG0242	peptide deformylase activity
S100027_01873	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S100027_01874	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100027_01874	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S100027_01875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S100027_01876	COG0631	protein serine/threonine phosphatase activity
S100027_01877	COG0515	serine threonine protein kinase
S100027_01877	COG2815	serine threonine protein kinase
S100027_01878	COG1162	GTPase activity
S100027_01879	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S100027_01880	COG1564	THIamine pyrophosphokinase
S100027_01881	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S100027_01882	COG1302	Protein conserved in bacteria
S100027_01883	COG1461	Dihydroxyacetone kinase
S100027_01884	COG1760	l-serine dehydratase
S100027_01885	COG1760	l-serine dehydratase
S100027_01886	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S100027_01887	COG1349	DNA-binding transcription factor activity
S100027_01888	COG0416	fatty acid biosynthetic process
S100027_01889	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S100027_01890	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_01891	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100027_01892	COG0571	ribonuclease III activity
S100027_01893	COG1196	nuclear chromosome segregation
S100027_01894	COG0552	protein localization to endoplasmic reticulum
S100027_01895	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S100027_01896	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S100027_01897	COG0228	four-way junction DNA binding
S100027_01898	COG1837	Belongs to the UPF0109 family
S100027_01900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S100027_01901	COG0336	Belongs to the RNA methyltransferase TrmD family
S100027_01902	COG0335	large ribosomal subunit rRNA binding
S100027_01903	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100027_01904	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100027_01906	COG2257	FlhB HrpN YscU SpaS Family
S100027_01907	COG0045	succinate-CoA ligase (ADP-forming) activity
S100027_01908	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S100027_01909	COG0758	DNA mediated transformation
S100027_01910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100027_01911	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S100027_01912	COG4974	Belongs to the 'phage' integrase family
S100027_01913	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S100027_01914	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S100027_01915	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S100027_01917	COG1815	bacterial-type flagellum-dependent cell motility
S100027_01918	COG1558	bacterial-type flagellum-dependent cell motility
S100027_01919	COG1677	Flagellar hook-basal body complex protein FliE
S100027_01920	COG1766	The M ring may be actively involved in energy transduction
S100027_01921	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100027_01922	COG1317	bacterial-type flagellum organization
S100027_01923	COG1157	protein secretion by the type III secretion system
S100027_01924	COG2882	bacterial-type flagellum organization
S100027_01926	COG3144	bacterial-type flagellum assembly
S100027_01927	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S100027_01928	COG4786	Flagellar basal body rod
S100027_01929	COG1580	Controls the rotational direction of flagella during chemotaxis
S100027_01930	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100027_01931	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100027_01931	COG1776	CheC inhibitor of MCP methylation
S100027_01932	COG2201	protein-glutamate methylesterase activity
S100027_01933	COG3190	flagellar
S100027_01934	COG1338	Plays a role in the flagellum-specific transport system
S100027_01935	COG1987	bacterial-type flagellum assembly
S100027_01936	COG1684	flagellar biosynthetic protein fliR
S100027_01937	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S100027_01938	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S100027_01939	COG1419	protein localization to endoplasmic reticulum
S100027_01940	COG0455	bacterial-type flagellum organization
S100027_01941	COG2201	protein-glutamate methylesterase activity
S100027_01942	COG0643	Histidine kinase
S100027_01942	COG2198	Histidine kinase
S100027_01943	COG0835	chemotaxis
S100027_01944	COG1776	CheC inhibitor of MCP methylation
S100027_01945	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
S100027_01946	COG1191	sigma factor activity
S100027_01948	COG0052	Belongs to the universal ribosomal protein uS2 family
S100027_01949	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S100027_01950	COG0528	UMP kinase activity
S100027_01951	COG0233	cytoplasmic translational termination
S100027_01952	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S100027_01953	COG4589	Belongs to the CDS family
S100027_01954	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S100027_01955	COG0750	zinc metalloprotease
S100027_01956	COG0442	prolyl-tRNA aminoacylation
S100027_01957	COG2176	DNA-directed DNA polymerase activity
S100027_01963	COG0779	Required for maturation of 30S ribosomal subunits
S100027_01964	COG0195	Participates in both transcription termination and antitermination
S100027_01965	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S100027_01966	COG1358	cellular component organization or biogenesis
S100027_01967	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S100027_01968	COG1550	Protein conserved in bacteria
S100027_01969	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S100027_01970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S100027_01971	COG0196	riboflavin kinase activity
S100027_01972	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S100027_01973	COG1185	polyribonucleotide nucleotidyltransferase activity
S100027_01974	COG0726	polysaccharide deacetylase
S100027_01975	COG0612	Peptidase, M16
S100027_01976	COG1873	PFAM PRC-barrel domain
S100027_01977	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100027_01978	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100027_01979	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S100027_01980	COG0527	aspartate kinase activity
S100027_01982	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S100027_01983	COG0740	serine-type endopeptidase activity
S100027_01985	COG1674	ftsk spoiiie
S100027_01985	COG4980	gas vesicle protein
S100027_01986	COG2188	Transcriptional regulator
S100027_01987	COG2814	Major facilitator Superfamily
S100027_01988	COG0612	Peptidase, M16
S100027_01989	COG0612	Peptidase, M16
S100027_01990	COG0300	oxidoreductase activity
S100027_01993	COG1426	Protein conserved in bacteria
S100027_01994	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S100027_01995	COG1546	Belongs to the CinA family
S100027_01995	COG1058	Belongs to the CinA family
S100027_01996	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S100027_01997	COG1418	mRNA catabolic process
S100027_01998	COG1692	metallophosphoesterase
S100027_01999	COG2359	stage V sporulation protein S
S100027_02001	COG1063	alcohol dehydrogenase
S100027_02002	COG0156	8-amino-7-oxononanoate synthase activity
S100027_02003	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S100027_02004	COG4550	Control of competence regulator ComK, YlbF/YmcA
S100027_02006	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S100027_02007	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S100027_02008	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S100027_02009	COG5444	nuclease activity
S100027_02012	COG0523	cobalamin synthesis protein
S100027_02014	COG1247	-acetyltransferase
S100027_02017	COG1231	oxidoreductase activity
S100027_02018	COG3619	membrane
S100027_02019	COG3263	regulation of cellular component size
S100027_02020	COG2814	Major facilitator Superfamily
S100027_02021	COG2814	Major facilitator Superfamily
S100027_02022	COG2267	carboxylic ester hydrolase activity
S100027_02023	COG0393	Putative heavy-metal-binding
S100027_02024	COG0398	Pfam SNARE associated Golgi protein
S100027_02025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100027_02026	COG1819	glycosyl
S100027_02027	COG0531	amino acid
S100027_02028	COG5577	PFAM Coat F domain
S100027_02030	COG3858	chitin binding
S100027_02030	COG1388	LysM domain
S100027_02031	COG1309	transcriptional regulator
S100027_02032	COG3631	Ketosteroid isomerase-related protein
S100027_02033	COG0702	epimerase
S100027_02035	COG1764	response to oxidative stress
S100027_02036	COG2076	Multidrug Resistance protein
S100027_02037	COG2076	Multidrug Resistance protein
S100027_02040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S100027_02041	COG1923	regulation of RNA biosynthetic process
S100027_02043	COG1780	Probably involved in ribonucleotide reductase function
S100027_02044	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100027_02045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100027_02046	COG4112	unkown
S100027_02049	COG0822	iron-sulfur transferase activity
S100027_02050	COG0735	belongs to the Fur family
S100027_02051	COG1802	Transcriptional regulator
S100027_02052	COG0697	spore germination
S100027_02058	COG1309	transcriptional regulator
S100027_02066	COG4282	regulation of fungal-type cell wall biogenesis
S100027_02067	COG4282	regulation of fungal-type cell wall biogenesis
S100027_02068	COG5444	nuclease activity
S100027_02072	COG0464	growth
S100027_02073	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S100027_02074	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
S100027_02075	COG0789	Transcriptional regulator
S100027_02076	COG0174	glutamine synthetase
S100027_02084	COG1073	alpha beta
S100027_02093	COG1309	transcriptional regulator
S100027_02094	COG2076	Multidrug Resistance protein
S100027_02095	COG2076	Multidrug Resistance protein
S100027_02097	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100027_02100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100027_02101	COG3546	catalase activity
S100027_02106	COG1846	Transcriptional regulator
S100027_02107	COG0778	Nitroreductase
S100027_02108	COG0346	lactoylglutathione lyase activity
S100027_02109	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S100027_02110	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100027_02113	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
S100027_02114	COG3209	COG3209 Rhs family protein
S100027_02115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S100027_02116	COG1388	LysM domain
S100027_02117	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S100027_02118	COG4224	UPF0291 protein
S100027_02119	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S100027_02121	COG3763	UPF0154 protein
S100027_02123	COG0785	Cytochrome C biogenesis protein
S100027_02124	COG2201	protein-glutamate methylesterase activity
S100027_02125	COG4846	Membrane protein involved in cytochrome C biogenesis
S100027_02127	COG0071	Belongs to the small heat shock protein (HSP20) family
S100027_02128	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S100027_02129	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100027_02133	COG0824	Thioesterase
S100027_02137	COG4841	protein insertion into membrane
S100027_02138	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S100027_02139	COG1832	CoA-binding protein
S100027_02140	COG0187	DNA topoisomerase II activity
S100027_02141	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S100027_02142	COG1609	Transcriptional regulator
S100027_02145	COG2160	L-arabinose isomerase activity
S100027_02150	COG1115	amino acid carrier protein
S100027_02152	COG2181	nitrate reductase activity
S100027_02153	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
S100027_02154	COG1140	nitrate reductase beta subunit
S100027_02155	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
S100027_02159	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100027_02161	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100027_02162	COG2223	nitrite transmembrane transporter activity
S100027_02164	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S100027_02166	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
S100027_02168	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
S100027_02170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100027_02172	COG0492	ferredoxin-NADP+ reductase activity
S100027_02175	COG3420	alginic acid biosynthetic process
S100027_02176	COG1114	Component of the transport system for branched-chain amino acids
S100027_02177	COG1064	alcohol dehydrogenase
S100027_02178	COG0789	Transcriptional regulator
S100027_02183	COG1024	Enoyl-CoA hydratase
S100027_02184	COG1012	belongs to the aldehyde dehydrogenase family
S100027_02185	COG2084	Dehydrogenase
S100027_02186	COG1960	acyl-CoA dehydrogenase activity
S100027_02187	COG1482	cell wall glycoprotein biosynthetic process
S100027_02188	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100027_02188	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100027_02188	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100027_02192	COG3711	transcriptional antiterminator
S100027_02192	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100027_02195	COG1725	Transcriptional regulator
S100027_02196	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_02197	COG1312	Catalyzes the dehydration of D-mannonate
S100027_02200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
S100027_02202	COG1609	Transcriptional regulator
S100027_02203	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100027_02204	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S100027_02205	COG0640	Transcriptional regulator
S100027_02206	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
S100027_02209	COG1649	PFAM Uncharacterised BCR, COG1649
S100027_02210	COG2404	hydrolase activity, acting on ester bonds
S100027_02211	COG2404	hydrolase activity, acting on ester bonds
S100027_02212	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
S100027_02214	COG2027	D-alanyl-D-alanine carboxypeptidase
S100027_02215	COG2323	membrane
S100027_02216	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100027_02218	COG2323	membrane
S100027_02221	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100027_02224	COG2801	Transposase and inactivated derivatives
S100027_02225	COG3546	catalase activity
S100027_02229	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100027_02233	COG1252	NADH dehydrogenase
S100027_02236	COG0166	Belongs to the GPI family
S100027_02238	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100027_02239	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S100027_02240	COG1024	Enoyl-CoA hydratase
S100027_02241	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S100027_02242	COG0511	ligase activity, forming carbon-carbon bonds
S100027_02243	COG0439	Biotin carboxylase
S100027_02244	COG0318	PFAM AMP-dependent synthetase and ligase
S100027_02245	COG1960	acyl-CoA dehydrogenase activity
S100027_02246	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100027_02247	COG1733	regulation of RNA biosynthetic process
S100027_02248	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S100027_02249	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S100027_02252	COG2323	membrane
S100027_02253	COG0306	phosphate transporter
S100027_02254	COG0175	sulfate reduction
S100027_02255	COG1809	phosphosulfolactate synthase activity
S100027_02256	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100027_02257	COG4948	Mandelate Racemase Muconate Lactonizing
S100027_02258	COG2814	Major facilitator Superfamily
S100027_02259	COG0463	Glycosyl transferase, family 2
S100027_02262	COG0493	'glutamate synthase
S100027_02263	COG0069	glutamate synthase activity
S100027_02263	COG0070	glutamate synthase
S100027_02263	COG0067	glutamate synthase
S100027_02264	COG0583	DNA-binding transcription factor activity
S100027_02268	COG1846	Transcriptional regulator
S100027_02270	COG1132	(ABC) transporter
S100027_02272	COG0300	oxidoreductase activity
S100027_02273	COG3848	Pyruvate phosphate dikinase
S100027_02273	COG0574	Belongs to the PEP-utilizing enzyme family
S100027_02274	COG0477	Major facilitator Superfamily
S100027_02275	COG0243	molybdopterin cofactor binding
S100027_02276	COG1846	Transcriptional regulator
S100027_02277	COG2814	Major facilitator Superfamily
S100027_02278	COG0531	amino acid
S100027_02280	COG0531	amino acid
S100027_02281	COG0531	amino acid
S100027_02282	COG0697	spore germination
S100027_02284	COG0840	transmembrane signaling receptor activity
S100027_02285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100027_02286	COG1404	Belongs to the peptidase S8 family
S100027_02288	COG1309	transcriptional regulator
S100027_02289	COG1846	Transcriptional regulator
S100027_02295	COG1309	transcriptional regulator
S100027_02296	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100027_02297	COG3708	Transcriptional regulator
S100027_02299	COG2378	regulation of single-species biofilm formation
S100027_02301	COG0640	Transcriptional regulator
S100027_02302	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100027_02304	COG0531	amino acid
S100027_02305	COG0741	lytic transglycosylase activity
S100027_02306	COG1086	Polysaccharide biosynthesis protein
S100027_02310	COG2322	membrane
S100027_02313	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100027_02314	COG1388	LysM domain
S100027_02314	COG3584	3D domain protein
S100027_02315	COG0514	ATP-dependent DNA helicase (RecQ)
S100027_02320	COG2315	Protein conserved in bacteria
S100027_02322	COG2427	Protein of unknown function (DUF1641)
S100027_02323	COG3383	formate dehydrogenase (NAD+) activity
S100027_02325	COG5444	nuclease activity
S100027_02327	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
S100027_02337	COG0402	S-adenosylhomocysteine deaminase activity
S100027_02340	COG2267	carboxylic ester hydrolase activity
S100027_02343	COG1280	lysine exporter protein (LysE YggA)
S100027_02344	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100027_02346	COG3848	Pyruvate phosphate dikinase
S100027_02346	COG0574	Belongs to the PEP-utilizing enzyme family
S100027_02347	COG1309	transcriptional regulator
S100027_02350	COG2318	DinB family
S100027_02351	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100027_02352	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100027_02355	COG1012	belongs to the aldehyde dehydrogenase family
S100027_02356	COG2814	Major facilitator Superfamily
S100027_02359	COG1657	PFAM Prenyltransferase squalene oxidase
S100027_02360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S100027_02362	COG0733	neurotransmitter:sodium symporter activity
S100027_02363	COG0385	Bile acid
S100027_02364	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100027_02365	COG0567	Dehydrogenase, E1 component
S100027_02366	COG4548	von Willebrand factor, type A
S100027_02367	COG0714	Associated with various cellular activities
S100027_02368	COG2032	superoxide dismutase activity
S100027_02369	COG0791	NLP P60 protein
S100027_02369	COG1388	LysM domain
S100027_02370	COG0534	Mate efflux family protein
S100027_02371	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100027_02372	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100027_02374	COG2962	Rard protein
S100027_02377	COG4305	rare lipoprotein A
S100027_02379	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_02380	COG1733	regulation of RNA biosynthetic process
S100027_02381	COG0778	Nitroreductase
S100027_02382	COG0400	carboxylic ester hydrolase activity
S100027_02384	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100027_02385	COG2801	Transposase and inactivated derivatives
S100027_02387	COG0793	Belongs to the peptidase S41A family
S100027_02387	COG3409	Peptidoglycan-binding domain 1 protein
S100027_02388	COG2226	methyltransferase
S100027_02390	COG1876	peptidase activity
S100027_02391	COG0813	purine-nucleoside phosphorylase activity
S100027_02392	COG0701	Predicted permease
S100027_02396	COG0671	phosphoesterase, PA-phosphatase related
S100027_02400	COG4479	Belongs to the UPF0346 family
S100027_02402	COG1509	lysine 2,3-aminomutase activity
S100027_02403	COG0456	acetyltransferase
S100027_02404	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100027_02405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S100027_02406	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S100027_02407	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100027_02409	COG0456	acetyltransferase
S100027_02410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100027_02411	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100027_02412	COG1846	Transcriptional regulator
S100027_02414	COG3706	GGDEF domain
S100027_02415	COG0534	Mate efflux family protein
S100027_02418	COG4698	Protein conserved in bacteria
S100027_02419	COG2755	lipolytic protein G-D-S-L family
S100027_02420	COG1999	signal sequence binding
S100027_02423	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S100027_02424	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100027_02425	COG1272	protein, Hemolysin III
S100027_02426	COG0204	Acyl-transferase
S100027_02427	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100027_02428	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100027_02430	COG2136	Putative SAM-dependent methyltransferase
S100027_02430	COG2521	methyltransferase
S100027_02432	COG0129	dihydroxy-acid dehydratase activity
S100027_02433	COG1413	lyase activity
S100027_02434	COG1418	mRNA catabolic process
S100027_02435	COG0386	Belongs to the glutathione peroxidase family
S100027_02436	COG2759	Belongs to the formate--tetrahydrofolate ligase family
S100027_02437	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S100027_02438	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100027_02440	COG1278	Cold shock
S100027_02444	COG0328	RNA-DNA hybrid ribonuclease activity
S100027_02445	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
S100027_02446	COG0328	RNA-DNA hybrid ribonuclease activity
S100027_02448	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100027_02451	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S100027_02452	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S100027_02453	COG1755	Isoprenylcysteine carboxyl methyltransferase
S100027_02454	COG3424	synthase
S100027_02455	COG0456	acetyltransferase
S100027_02456	COG2233	PERMEase
S100027_02457	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100027_02458	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
S100027_02459	COG1199	ATP-dependent helicase activity
S100027_02462	COG0116	Belongs to the methyltransferase superfamily
S100027_02463	COG3599	regulation of cell shape
S100027_02464	COG4474	Belongs to the UPF0398 family
S100027_02467	COG3359	exonuclease
S100027_02468	COG1205	dead DEAH box helicase
S100027_02468	COG1111	helicase
S100027_02469	COG2190	(PTS) system
S100027_02470	COG0071	Belongs to the small heat shock protein (HSP20) family
S100027_02477	COG3331	DNA recombination
S100027_02478	COG4499	WXG100 protein secretion system (Wss), protein YukC
S100027_02478	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100027_02480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S100027_02481	COG3935	DnaD domain protein
S100027_02482	COG0017	Asparaginyl-tRNA synthetase
S100027_02483	COG0436	Aminotransferase
S100027_02484	COG5353	protein conserved in bacteria
S100027_02486	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S100027_02486	COG1199	ATP-dependent helicase activity
S100027_02487	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
S100027_02488	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S100027_02489	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S100027_02491	COG0617	tRNA 3'-terminal CCA addition
S100027_02492	COG0438	transferase activity, transferring glycosyl groups
S100027_02493	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100027_02494	COG1803	Methylglyoxal synthase
S100027_02495	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S100027_02496	COG1694	Mazg nucleotide pyrophosphohydrolase
S100027_02497	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100027_02499	COG4347	Protein of unknown function (DUF1405)
S100027_02500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S100027_02500	COG2010	Cytochrome c
S100027_02501	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S100027_02502	COG0723	plastoquinol--plastocyanin reductase activity
S100027_02504	COG5582	Belongs to the UPF0302 family
S100027_02505	COG0457	Tetratricopeptide repeat
S100027_02506	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S100027_02507	COG0287	Prephenate dehydrogenase
S100027_02508	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S100027_02509	COG0159	tryptophan synthase activity
S100027_02510	COG0133	tryptophan synthase activity
S100027_02511	COG0135	phosphoribosylanthranilate isomerase activity
S100027_02512	COG0134	indole-3-glycerol-phosphate synthase activity
S100027_02513	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S100027_02514	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S100027_02515	COG4401	Chorismate mutase type I
S100027_02516	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S100027_02517	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S100027_02518	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S100027_02519	COG0105	UTP biosynthetic process
S100027_02520	COG0142	geranyltranstransferase activity
S100027_02521	COG2226	methyltransferase
S100027_02522	COG0142	geranyltranstransferase activity
S100027_02525	COG0776	regulation of translation
S100027_02526	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S100027_02529	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S100027_02530	COG1160	GTP binding
S100027_02535	COG1304	FMN binding
S100027_02536	COG0539	negative regulation of cytoplasmic translation
S100027_02537	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S100027_02539	COG2959	enzyme of heme biosynthesis
S100027_02540	COG3409	Peptidoglycan-binding domain 1 protein
S100027_02540	COG3773	Cell wall hydrolase
S100027_02541	COG2339	peptidase activity
S100027_02543	COG0492	ferredoxin-NADP+ reductase activity
S100027_02544	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100027_02545	COG4862	establishment of competence for transformation
S100027_02546	COG1408	metallophosphoesterase
S100027_02548	COG1388	LysM domain
S100027_02549	COG1266	CAAX protease self-immunity
S100027_02550	COG0514	ATP-dependent DNA helicase (RecQ)
S100027_02551	COG4955	Helix-turn-helix domain
S100027_02552	COG1141	Ferredoxin
S100027_02553	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S100027_02554	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S100027_02555	COG0739	heme binding
S100027_02557	COG1595	DNA-templated transcription, initiation
S100027_02559	COG0726	polysaccharide deacetylase
S100027_02561	COG5002	protein histidine kinase activity
S100027_02562	COG0745	RESPONSE REGULATOR receiver
S100027_02563	COG5002	protein histidine kinase activity
S100027_02564	COG0745	RESPONSE REGULATOR receiver
S100027_02565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S100027_02566	COG1333	cytochrome c biogenesis protein
S100027_02567	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100027_02568	COG1187	pseudouridine synthase activity
S100027_02569	COG0700	Nucleoside recognition
S100027_02570	COG2715	membrane protein required for spore maturation
S100027_02571	COG1686	Belongs to the peptidase S11 family
S100027_02573	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S100027_02574	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S100027_02576	COG1547	Domain of unknown function (DUF309)
S100027_02577	COG0456	acetyltransferase
S100027_02578	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S100027_02579	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100027_02579	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100027_02580	COG0307	riboflavin synthase, alpha
S100027_02581	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100027_02581	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100027_02586	COG0457	Tetratricopeptide repeat
S100027_02587	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S100027_02588	COG4086	secreted protein
S100027_02589	COG4195	phage-related replication protein
S100027_02590	COG0019	diaminopimelate decarboxylase activity
S100027_02592	COG0697	spore germination
S100027_02595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100027_02600	COG2172	sigma factor antagonist activity
S100027_02602	COG1686	Belongs to the peptidase S11 family
S100027_02603	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S100027_02604	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S100027_02605	COG4974	Belongs to the 'phage' integrase family
S100027_02607	COG0735	belongs to the Fur family
S100027_02608	COG1300	Membrane
S100027_02609	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100027_02611	COG1953	Uracil, thiamine, allantoin
S100027_02612	COG1953	Uracil, thiamine, allantoin
S100027_02615	COG2153	protein acetylation
S100027_02616	COG1379	DNA repair
S100027_02617	COG0494	nUDIX hydrolase
S100027_02619	COG1309	transcriptional regulator
S100027_02621	COG0667	Aldo Keto reductase
S100027_02623	COG1073	alpha beta
S100027_02625	COG4918	Iron-sulphur cluster biosynthesis
S100027_02627	COG0456	acetyltransferase
S100027_02627	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S100027_02628	COG2329	Antibiotic biosynthesis monooxygenase
S100027_02629	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S100027_02631	COG0747	negative chemotaxis
S100027_02632	COG0601	transmembrane transport
S100027_02633	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100027_02634	COG0444	Belongs to the ABC transporter superfamily
S100027_02635	COG0534	Mate efflux family protein
S100027_02639	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100027_02641	COG2211	Major facilitator Superfamily
S100027_02642	COG0346	lactoylglutathione lyase activity
S100027_02643	COG1072	(Pantothenic acid kinase))
S100027_02649	COG4195	phage-related replication protein
S100027_02650	COG0300	oxidoreductase activity
S100027_02651	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100027_02652	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100027_02653	COG4187	Peptidase family M20/M25/M40
S100027_02654	COG1902	pentaerythritol trinitrate reductase activity
S100027_02656	COG0596	Alpha beta hydrolase
S100027_02657	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S100027_02658	COG1234	tRNA 3'-trailer cleavage
S100027_02659	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S100027_02663	COG2188	Transcriptional regulator
S100027_02664	COG2723	6-phospho-beta-galactosidase activity
S100027_02665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100027_02666	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100027_02667	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100027_02668	COG1785	Belongs to the alkaline phosphatase family
S100027_02669	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_02670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S100027_02671	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100027_02673	COG0706	membrane insertase activity
S100027_02674	COG2195	Cleaves the N-terminal amino acid of tripeptides
S100027_02675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S100027_02676	COG4129	membrane
S100027_02677	COG1126	abc transporter atp-binding protein
S100027_02678	COG0765	amino acid transport
S100027_02679	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100027_02682	COG1597	lipid kinase activity
S100027_02683	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100027_02684	COG0022	dehydrogenase e1 component
S100027_02685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100027_02686	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100027_02687	COG3426	butyrate kinase activity
S100027_02689	COG0280	phosphate acetyltransferase
S100027_02690	COG3290	protein histidine kinase activity
S100027_02690	COG3829	transcription factor binding
S100027_02692	COG0584	glycerophosphoryl diester phosphodiesterase
S100027_02693	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100027_02695	COG1045	serine acetyltransferase
S100027_02697	COG0745	RESPONSE REGULATOR receiver
S100027_02698	COG0750	zinc metalloprotease
S100027_02699	COG0497	DNA recombination
S100027_02700	COG1438	arginine binding
S100027_02701	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S100027_02702	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S100027_02703	COG0142	geranyltranstransferase activity
S100027_02704	COG1722	exodeoxyribonuclease VII activity
S100027_02705	COG1570	exodeoxyribonuclease VII activity
S100027_02706	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S100027_02707	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100027_02708	COG1302	Protein conserved in bacteria
S100027_02709	COG0439	Biotin carboxylase
S100027_02710	COG0511	ligase activity, forming carbon-carbon bonds
S100027_02718	COG3854	ATPases associated with a variety of cellular activities
S100027_02720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S100027_02721	COG0006	proline dipeptidase activity
S100027_02722	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S100027_02724	COG3872	metal-dependent enzyme
S100027_02726	COG1752	Esterase of the alpha-beta hydrolase superfamily
S100027_02727	COG1321	iron dependent repressor
S100027_02728	COG0095	Lipoate-protein ligase
S100027_02729	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100027_02730	COG2113	Glycine betaine
S100027_02731	COG4176	ABC-type proline glycine betaine transport system permease component
S100027_02732	COG0517	IMP dehydrogenase activity
S100027_02732	COG4175	Glycine betaine
S100027_02733	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S100027_02734	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S100027_02735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S100027_02736	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S100027_02741	COG0681	Belongs to the peptidase S26 family
S100027_02746	COG4940	Competence protein ComGF
S100027_02747	COG4970	Tfp pilus assembly protein FimT
S100027_02748	COG4537	Required for transformation and DNA binding
S100027_02749	COG1459	type II secretion system
S100027_02750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S100027_02751	COG1366	Belongs to the anti-sigma-factor antagonist family
S100027_02753	COG1393	Belongs to the ArsC family
S100027_02755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100027_02757	COG0011	TIGRFAM Protein of
S100027_02759	COG2866	Carboxypeptidase
S100027_02760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100027_02762	COG1368	sulfuric ester hydrolase activity
S100027_02763	COG1940	carbohydrate kinase activity
S100027_02764	COG4483	Protein conserved in bacteria
S100027_02765	COG0697	spore germination
S100027_02766	COG0457	Tetratricopeptide repeat
S100027_02766	COG0705	Rhomboid family
S100027_02768	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S100027_02769	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S100027_02770	COG0438	transferase activity, transferring glycosyl groups
S100027_02773	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S100027_02774	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100027_02775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100027_02776	COG0581	inorganic phosphate transmembrane transporter activity
S100027_02777	COG0573	inorganic phosphate transmembrane transporter activity
S100027_02778	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S100027_02780	COG0477	Major facilitator Superfamily
S100027_02781	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S100027_02782	COG2839	Protein conserved in bacteria
S100027_02783	COG5521	maltodextrose utilization protein MalA
S100027_02784	COG1388	LysM domain
S100027_02785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S100027_02786	COG4709	membrane
S100027_02787	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
S100027_02788	COG0735	belongs to the Fur family
S100027_02789	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100027_02790	COG1121	(ABC) transporter
S100027_02791	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100027_02793	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S100027_02794	COG0513	Belongs to the DEAD box helicase family
S100027_02796	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S100027_02797	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S100027_02798	COG2384	SAM-dependent methyltransferase
S100027_02809	COG5444	nuclease activity
S100027_02812	COG2010	Cytochrome c
S100027_02813	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S100027_02814	COG0358	DNA primase activity
S100027_02815	COG1671	Belongs to the UPF0178 family
S100027_02816	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S100027_02817	COG0517	IMP dehydrogenase activity
S100027_02818	COG0751	glycine-tRNA ligase activity
S100027_02819	COG0752	glycyl-tRNA synthetase alpha subunit
S100027_02820	COG1381	Involved in DNA repair and RecF pathway recombination
S100027_02822	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S100027_02823	COG0295	cytidine deaminase activity
S100027_02824	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S100027_02825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S100027_02826	COG1480	7TM receptor with intracellular HD hydrolase
S100027_02827	COG1702	phosphate starvation-inducible protein PhoH
S100027_02828	COG0561	phosphatase activity
S100027_02831	COG4864	UPF0365 protein
S100027_02832	COG1030	water channel activity
S100027_02833	COG1610	YqeY-like protein
S100027_02834	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S100027_02835	COG1283	sodium-dependent phosphate transmembrane transporter activity
S100027_02836	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S100027_02837	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S100027_02838	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S100027_02839	COG2264	protein methyltransferase activity
S100027_02840	COG0484	heat shock protein binding
S100027_02841	COG0443	Heat shock 70 kDa protein
S100027_02842	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S100027_02843	COG1420	regulation of RNA biosynthetic process
S100027_02844	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S100027_02845	COG0481	GTPase activity
S100027_02847	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100027_02848	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
S100027_02849	COG0268	Binds directly to 16S ribosomal RNA
S100027_02850	COG1466	dna polymerase III delta subunit
S100027_02852	COG0658	competence protein
S100027_02852	COG2333	competence protein COMEC
S100027_02853	COG2131	deaminase
S100027_02854	COG1555	photosystem II stabilization
S100027_02854	COG1596	polysaccharide export
S100027_02855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100027_02856	COG2226	methyltransferase
S100027_02857	COG0799	negative regulation of ribosome biogenesis
S100027_02858	COG1713	HD superfamily hydrolase involved in NAD metabolism
S100027_02859	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S100027_02860	COG1534	Rna-binding protein
S100027_02861	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S100027_02862	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100027_02863	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
S100027_02865	COG2755	lipolytic protein G-D-S-L family
S100027_02866	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100027_02867	COG5609	conserved protein (DUF2294)
S100027_02868	COG3383	formate dehydrogenase (NAD+) activity
S100027_02869	COG2427	Protein of unknown function (DUF1641)
S100027_02876	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100027_02884	COG1136	(ABC) transporter
S100027_02885	COG0577	efflux transmembrane transporter activity
S100027_02898	COG2197	response regulator
S100027_02899	COG4585	Histidine kinase
S100027_02900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100027_02901	COG0730	response to heat
S100027_02902	COG0425	Belongs to the sulfur carrier protein TusA family
S100027_02903	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100027_02903	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100027_02904	COG0425	Belongs to the sulfur carrier protein TusA family
S100027_02904	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100027_02905	COG2210	Belongs to the sulfur carrier protein TusA family
S100027_02906	COG1937	Protein conserved in bacteria
S100027_02910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S100027_02912	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
S100027_02913	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
S100027_02914	COG1733	regulation of RNA biosynthetic process
S100027_02915	COG3239	Fatty acid desaturase
S100027_02916	COG4585	Histidine kinase
S100027_02917	COG2197	response regulator
S100027_02918	COG0492	ferredoxin-NADP+ reductase activity
S100027_02919	COG0747	negative chemotaxis
S100027_02920	COG0601	transmembrane transport
S100027_02922	COG0444	Belongs to the ABC transporter superfamily
S100027_02923	COG4608	Belongs to the ABC transporter superfamily
S100027_02927	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_02930	COG2124	cytochrome p450
S100027_02931	COG0730	response to heat
S100027_02933	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_02934	COG1621	beta-fructofuranosidase activity
S100027_02935	COG3716	PTS system mannose fructose sorbose family IID component
S100027_02936	COG3715	PTS system
S100027_02937	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_02938	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100027_02939	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100027_02939	COG3933	PFAM sigma-54 factor interaction domain-containing protein
S100027_02940	COG3933	PFAM sigma-54 factor interaction domain-containing protein
S100027_02940	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100027_02944	COG2169	Transcriptional regulator
S100027_02945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100027_02946	COG0656	L-ascorbic acid biosynthetic process
S100027_02947	COG2814	Major facilitator Superfamily
S100027_02948	COG1733	regulation of RNA biosynthetic process
S100027_02949	COG3340	Belongs to the peptidase S51 family
S100027_02950	COG1587	Uroporphyrinogen-III synthase
S100027_02952	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100027_02953	COG0583	DNA-binding transcription factor activity
S100027_02954	COG2814	Major facilitator Superfamily
S100027_02956	COG2124	cytochrome p450
S100027_02956	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100027_02957	COG1309	transcriptional regulator
S100027_02958	COG1404	Belongs to the peptidase S8 family
S100027_02959	COG2226	methyltransferase
S100027_02963	COG0626	cystathionine gamma-synthase activity
S100027_02964	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100027_02965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S100027_02966	COG2226	methyltransferase
S100027_02969	COG0768	penicillin binding
S100027_02970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S100027_02971	COG0572	uridine kinase
S100027_02975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S100027_02976	COG3906	Belongs to the UPF0473 family
S100027_02977	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S100027_02978	COG4472	Bacterial protein of unknown function (DUF965)
S100027_02979	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S100027_02980	COG0628	permease
S100027_02982	COG3881	PFAM PRC-barrel domain
S100027_02983	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S100027_02984	COG0457	Tetratricopeptide repeat
S100027_02985	COG0482	sulfurtransferase activity
S100027_02986	COG1104	cysteine desulfurase activity
S100027_02987	COG1959	2 iron, 2 sulfur cluster binding
S100027_02988	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S100027_02989	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S100027_02990	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S100027_02991	COG0124	histidyl-tRNA synthetase
S100027_02993	COG3103	Sh3 type 3 domain protein
S100027_02993	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100027_02993	COG4991	sh3 domain protein
S100027_02994	COG1490	D-aminoacyl-tRNA deacylase activity
S100027_02995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S100027_02996	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100027_02997	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S100027_02997	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S100027_02998	COG5416	Lipopolysaccharide assembly protein A domain
S100027_02999	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S100027_02999	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S100027_03001	COG2244	polysaccharide biosynthetic process
S100027_03002	COG2323	membrane
S100027_03004	COG1862	Preprotein translocase
S100027_03005	COG0343	queuine tRNA-ribosyltransferase activity
S100027_03006	COG0343	queuine tRNA-ribosyltransferase activity
S100027_03007	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S100027_03009	COG2255	four-way junction helicase activity
S100027_03010	COG0632	four-way junction helicase activity
S100027_03012	COG2112	serine threonine protein kinase
S100027_03015	COG2318	DinB family
S100027_03016	COG4195	phage-related replication protein
S100027_03019	COG0217	transcriptional regulatory protein
S100027_03022	COG1388	LysM domain
S100027_03023	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S100027_03024	COG0157	Belongs to the NadC ModD family
S100027_03025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S100027_03026	COG1104	cysteine desulfurase activity
S100027_03027	COG1827	regulation of RNA biosynthetic process
S100027_03028	COG0077	Prephenate dehydratase
S100027_03029	COG4492	Belongs to the UPF0735 family
S100027_03030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S100027_03031	COG3290	protein histidine kinase activity
S100027_03032	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S100027_03033	COG2868	ribosomal protein
S100027_03034	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S100027_03035	COG1994	Peptidase M50
S100027_03036	COG0739	heme binding
S100027_03037	COG3832	glyoxalase III activity
S100027_03038	COG0640	Transcriptional regulator
S100027_03039	COG2894	cell division
S100027_03040	COG0850	regulation of cytokinetic process
S100027_03041	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
S100027_03042	COG1792	Involved in formation and maintenance of cell shape
S100027_03043	COG1077	Cell shape determining protein MreB Mrl
S100027_03044	COG2003	Belongs to the UPF0758 family
S100027_03048	COG0457	Tetratricopeptide repeat
S100027_03049	COG5444	nuclease activity
S100027_03059	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100027_03073	COG4626	Terminase
S100027_03073	COG1802	Transcriptional regulator
S100027_03100	COG2003	Belongs to the UPF0758 family
S100027_03101	COG0424	maF-like protein
S100027_03103	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S100027_03104	COG0285	dihydrofolate synthase activity
S100027_03105	COG0525	valine-tRNA ligase activity
S100027_03106	COG0525	valine-tRNA ligase activity
S100027_03108	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100027_03109	COG1388	LysM domain
S100027_03110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S100027_03111	COG0113	porphobilinogen synthase activity
S100027_03112	COG1587	Uroporphyrinogen-III synthase
S100027_03113	COG0181	hydroxymethylbilane synthase activity
S100027_03114	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S100027_03115	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S100027_03117	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S100027_03118	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S100027_03119	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S100027_03120	COG0470	DNA polymerase III
S100027_03120	COG1067	ATP-dependent peptidase activity
S100027_03121	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S100027_03122	COG0544	peptidyl-prolyl cis-trans isomerase activity
S100027_03123	COG1477	protein flavinylation
S100027_03123	COG0457	Tetratricopeptide repeat
S100027_03124	COG0066	3-isopropylmalate dehydratase activity
S100027_03125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S100027_03126	COG0473	3-isopropylmalate dehydrogenase activity
S100027_03127	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S100027_03128	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S100027_03129	COG0440	acetolactate synthase activity
S100027_03130	COG0028	Belongs to the TPP enzyme family
S100027_03131	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100027_03133	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100027_03136	COG5518	Phage portal protein
S100027_03137	COG1783	phage Terminase large subunit
S100027_03144	COG5444	nuclease activity
S100027_03145	COG0457	Tetratricopeptide repeat
S100027_03150	COG0622	Phosphoesterase
S100027_03151	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S100027_03152	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S100027_03153	COG5401	PFAM Sporulation and spore germination
S100027_03154	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S100027_03155	COG1846	Transcriptional regulator
S100027_03156	COG2197	response regulator
S100027_03157	COG4221	oxidoreductase activity
S100027_03158	COG0824	Thioesterase
S100027_03159	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S100027_03160	COG1053	succinate dehydrogenase
S100027_03161	COG2009	succinate dehydrogenase
S100027_03162	COG1719	4-vinyl reductase, 4VR
S100027_03163	COG0527	aspartate kinase activity
S100027_03164	COG0322	excinuclease ABC activity
S100027_03165	COG3118	belongs to the thioredoxin family
S100027_03166	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S100027_03167	COG2086	electron transfer activity
S100027_03168	COG1024	Enoyl-CoA hydratase
S100027_03169	COG1309	transcriptional regulator
S100027_03170	COG0318	PFAM AMP-dependent synthetase and ligase
S100027_03171	COG3766	membrane
S100027_03172	COG1193	negative regulation of DNA recombination
S100027_03173	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S100027_03173	COG1796	DNA polymerase
S100027_03174	COG1286	toxin biosynthetic process
S100027_03175	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
S100027_03176	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100027_03178	COG2801	Transposase and inactivated derivatives
S100027_03182	COG1137	ATPase activity
S100027_03185	COG0072	phenylalanine-tRNA ligase activity
S100027_03185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100027_03186	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S100027_03187	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100027_03189	COG1966	Carbon starvation protein
S100027_03192	COG0395	ABC-type sugar transport system, permease component
S100027_03193	COG1175	transmembrane transport
S100027_03194	COG1653	transport
S100027_03195	COG0371	Dehydrogenase
S100027_03196	COG0235	Class ii aldolase
S100027_03197	COG1069	ribulokinase activity
S100027_03198	COG2160	L-arabinose isomerase activity
S100027_03199	COG3507	Belongs to the glycosyl hydrolase 43 family
S100027_03200	COG1363	Peptidase, m42
S100027_03202	COG3326	Membrane
S100027_03203	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S100027_03204	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S100027_03205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S100027_03206	COG1346	cytolysis
S100027_03208	COG3540	Alkaline phosphatase
S100027_03209	COG3279	Response regulator of the LytR AlgR family
S100027_03210	COG3275	phosphorelay sensor kinase activity
S100027_03213	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100027_03215	COG0398	Pfam SNARE associated Golgi protein
S100027_03216	COG1484	DNA-dependent DNA replication
S100027_03217	COG3611	Membrane attachment protein
S100027_03218	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S100027_03220	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S100027_03221	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S100027_03222	COG3866	Pectate lyase
S100027_03223	COG0237	dephospho-CoA kinase activity
S100027_03224	COG1971	Probably functions as a manganese efflux pump
S100027_03225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S100027_03226	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100027_03226	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100027_03227	COG5002	protein histidine kinase activity
S100027_03228	COG0745	RESPONSE REGULATOR receiver
S100027_03229	COG0039	L-malate dehydrogenase activity
S100027_03230	COG0538	isocitrate dehydrogenase activity
S100027_03231	COG0372	Belongs to the citrate synthase family
S100027_03232	COG2707	UPF0756 membrane protein
S100027_03233	COG0628	permease
S100027_03234	COG3030	protein affecting phage T7 exclusion by the F plasmid
S100027_03236	COG0205	6-phosphofructokinase activity
S100027_03237	COG0825	malonyl-CoA metabolic process
S100027_03238	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S100027_03239	COG0281	malic enzyme
S100027_03240	COG0587	DNA-directed DNA polymerase activity
S100027_03244	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S100027_03246	COG4109	DRTGG domain
S100027_03247	COG1695	Transcriptional regulator
S100027_03248	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S100027_03249	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_03251	COG0165	Argininosuccinate lyase
S100027_03252	COG0137	argininosuccinate synthase activity
S100027_03253	COG0521	Mo-molybdopterin cofactor biosynthetic process
S100027_03254	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S100027_03255	COG0827	DNA restriction-modification system
S100027_03256	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
S100027_03257	COG3874	Sporulation protein YtfJ
S100027_03259	COG1714	RDD family
S100027_03260	COG0616	signal peptide processing
S100027_03261	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100027_03262	COG1566	PFAM secretion protein HlyD family protein
S100027_03263	COG0477	Major facilitator Superfamily
S100027_03265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100027_03267	COG0301	tRNA thio-modification
S100027_03268	COG1104	cysteine desulfurase activity
S100027_03269	COG1114	Component of the transport system for branched-chain amino acids
S100027_03271	COG2801	Transposase and inactivated derivatives
S100027_03272	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S100027_03273	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S100027_03274	COG1309	transcriptional regulator
S100027_03275	COG1956	GAF domain-containing protein
S100027_03276	COG2199	diguanylate cyclase activity
S100027_03276	COG2203	Gaf domain
S100027_03277	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S100027_03280	COG3152	Membrane
S100027_03281	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S100027_03282	COG1522	sequence-specific DNA binding
S100027_03284	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100027_03285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100027_03286	COG0454	-acetyltransferase
S100027_03287	COG0517	IMP dehydrogenase activity
S100027_03288	COG0123	including yeast histone deacetylase and acetoin utilization protein
S100027_03289	COG1360	Flagellar Motor Protein
S100027_03290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S100027_03291	COG1609	Transcriptional regulator
S100027_03292	COG1605	Chorismate mutase
S100027_03292	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
S100027_03295	COG3118	belongs to the thioredoxin family
S100027_03296	COG4980	gas vesicle protein
S100027_03297	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S100027_03298	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S100027_03299	COG1674	ftsk spoiiie
S100027_03300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100027_03301	COG4848	Belongs to the UPF0354 family
S100027_03302	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100027_03304	COG1363	Peptidase, m42
S100027_03305	COG5584	Small secreted protein
S100027_03306	COG0281	malic enzyme
S100027_03307	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100027_03308	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S100027_03310	COG0510	thiamine kinase activity
S100027_03311	COG1523	belongs to the glycosyl hydrolase 13 family
S100027_03312	COG1523	belongs to the glycosyl hydrolase 13 family
S100027_03313	COG1597	lipid kinase activity
S100027_03315	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S100027_03316	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100027_03318	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100027_03319	COG2252	PERMEase
S100027_03320	COG1349	DNA-binding transcription factor activity
S100027_03321	COG1187	pseudouridine synthase activity
S100027_03322	COG2244	polysaccharide biosynthetic process
S100027_03323	COG2081	HI0933 family
S100027_03324	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
S100027_03326	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100027_03328	COG0457	Tetratricopeptide repeat
S100027_03330	COG5578	integral membrane protein
S100027_03331	COG0673	inositol 2-dehydrogenase activity
S100027_03332	COG1653	transport
S100027_03333	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S100027_03334	COG4209	transmembrane transport
S100027_03335	COG2207	Transcriptional regulator
S100027_03336	COG1653	transport
S100027_03337	COG0395	ABC-type sugar transport system, permease component
S100027_03338	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100027_03339	COG1073	alpha beta
S100027_03341	COG0583	DNA-binding transcription factor activity
S100027_03342	COG0346	lactoylglutathione lyase activity
S100027_03343	COG0495	leucyl-tRNA aminoacylation
S100027_03345	COG2814	Major facilitator Superfamily
S100027_03347	COG2433	Pfam Transposase IS66
S100027_03348	COG0577	efflux transmembrane transporter activity
S100027_03349	COG1136	(ABC) transporter
S100027_03351	COG1131	(ABC) transporter
S100027_03352	COG1725	Transcriptional regulator
S100027_03355	COG1242	4 iron, 4 sulfur cluster binding
S100027_03356	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S100027_03357	COG1301	dicarboxylic acid transport
S100027_03359	COG2267	carboxylic ester hydrolase activity
S100027_03360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S100027_03361	COG0671	phosphoesterase, PA-phosphatase related
S100027_03362	COG0438	transferase activity, transferring glycosyl groups
S100027_03362	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100027_03363	COG0367	asparagine synthase
S100027_03364	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S100027_03365	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S100027_03368	COG1506	peptidase
S100027_03369	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S100027_03370	COG1116	anion transmembrane transporter activity
S100027_03371	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S100027_03372	COG0494	nUDIX hydrolase
S100027_03374	COG4824	toxin secretion phage lysis holin
S100027_03375	COG0783	Belongs to the Dps family
S100027_03378	COG1854	S-ribosylhomocysteine lyase activity
S100027_03379	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S100027_03380	COG0288	reversible hydration of carbon dioxide
S100027_03381	COG0523	cobalamin synthesis protein
S100027_03382	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100027_03383	COG0254	rRNA binding
S100027_03384	COG1271	oxidase subunit
S100027_03385	COG1294	oxidase, subunit
S100027_03388	COG4948	Mandelate Racemase Muconate Lactonizing
S100027_03389	COG0318	PFAM AMP-dependent synthetase and ligase
S100027_03390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S100027_03391	COG0596	Alpha beta hydrolase
S100027_03392	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
S100027_03393	COG1169	isochorismate synthase
S100027_03394	COG1575	Belongs to the MenA family. Type 1 subfamily
S100027_03395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100027_03396	COG0058	SHG alpha-glucan phosphorylase activity
S100027_03397	COG0058	SHG alpha-glucan phosphorylase activity
S100027_03398	COG0297	glycogen (starch) synthase activity
S100027_03399	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100027_03400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100027_03401	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S100027_03426	COG1609	Transcriptional regulator
S100027_03427	COG3859	Proton-coupled thiamine transporter YuaJ
S100027_03428	COG3764	Sortase (surface protein transpeptidase)
S100027_03431	COG0457	Tetratricopeptide repeat
S100027_03433	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
S100027_03434	COG0569	domain protein
S100027_03435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100027_03437	COG2318	DinB family
S100027_03439	COG1454	alcohol dehydrogenase
S100027_03441	COG1510	regulation of RNA biosynthetic process
S100027_03443	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
S100027_03444	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S100027_03445	COG2140	Oxalate decarboxylase
S100027_03457	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
S100027_03460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100027_03461	COG0726	polysaccharide deacetylase
S100027_03462	COG1408	metallophosphoesterase
S100027_03463	COG1968	undecaprenyl-diphosphatase activity
S100027_03464	COG0628	permease
S100027_03465	COG0673	inositol 2-dehydrogenase activity
S100027_03466	COG0693	protein deglycase activity
S100027_03467	COG0840	transmembrane signaling receptor activity
S100027_03468	COG0840	transmembrane signaling receptor activity
S100027_03469	COG0840	transmembrane signaling receptor activity
S100027_03470	COG0840	transmembrane signaling receptor activity
S100027_03472	COG2070	2-Nitropropane dioxygenase
S100027_03473	COG0432	Pfam Uncharacterised protein family UPF0047
S100027_03474	COG0366	Alpha amylase catalytic
S100027_03477	COG5297	Belongs to the glycosyl hydrolase family 6
S100027_03478	COG1253	flavin adenine dinucleotide binding
S100027_03479	COG2738	Putative neutral zinc metallopeptidase
S100027_03482	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S100027_03484	COG2323	membrane
S100027_03485	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S100027_03494	COG5444	nuclease activity
S100027_03502	COG5434	Belongs to the glycosyl hydrolase 28 family
S100027_03503	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100027_03505	COG3953	SLT domain
S100027_03505	COG5280	Phage tail tape measure protein TP901
S100027_03518	COG4626	Terminase
S100027_03518	COG1802	Transcriptional regulator
S100027_03542	COG0166	Belongs to the GPI family
S100027_03543	COG1979	alcohol dehydrogenase
S100027_03544	COG2155	Conserved Protein
S100027_03545	COG1098	S1 RNA binding domain
S100027_03546	COG0436	Aminotransferase
S100027_03547	COG1522	sequence-specific DNA binding
S100027_03548	COG2267	carboxylic ester hydrolase activity
S100027_03551	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S100027_03554	COG5018	Exonuclease
S100027_03555	COG2814	Major facilitator Superfamily
S100027_03556	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100027_03557	COG3011	Protein conserved in bacteria
S100027_03559	COG3290	protein histidine kinase activity
S100027_03560	COG4565	transcriptional regulatory protein
S100027_03561	COG1183	phosphatidylcholine synthase activity
S100027_03562	COG0586	Pfam SNARE associated Golgi protein
S100027_03563	COG0688	phosphatidylethanolamine metabolic process
S100027_03564	COG3493	citrate carrier protein
S100027_03566	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S100027_03566	COG2111	Na H antiporter
S100027_03567	COG2111	Na H antiporter
S100027_03568	COG1006	Multisubunit Na H antiporter MnhC subunit
S100027_03569	COG0651	ATP synthesis coupled electron transport
S100027_03570	COG1863	multisubunit Na H antiporter MnhE subunit
S100027_03571	COG2212	antiporter activity
S100027_03572	COG1320	monovalent cation:proton antiporter activity
S100027_03573	COG2050	protein possibly involved in aromatic compounds catabolism
S100027_03574	COG2197	response regulator
S100027_03575	COG4585	Histidine kinase
S100027_03581	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S100027_03582	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S100027_03583	COG1335	isochorismatase
S100027_03584	COG5506	Protein of unknown function (DUF1694)
S100027_03587	COG0628	permease
S100027_03588	COG1959	2 iron, 2 sulfur cluster binding
S100027_03591	COG1418	mRNA catabolic process
S100027_03592	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_03594	COG1511	domain protein
S100027_03595	COG1674	ftsk spoiiie
S100027_03595	COG0433	COG0433 Predicted ATPase
S100027_03596	COG4499	WXG100 protein secretion system (Wss), protein YukC
S100027_03597	COG5417	Belongs to the EsaB family
S100027_03598	COG4842	Belongs to the WXG100 family
S100027_03599	COG1115	amino acid carrier protein
S100027_03600	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S100027_03600	COG2508	Transcriptional regulator
S100027_03601	COG0686	Belongs to the AlaDH PNT family
S100027_03603	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S100027_03604	COG1268	BioY protein
S100027_03605	COG2056	Na+-H+ antiporter family
S100027_03606	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S100027_03607	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
S100027_03608	COG3584	3D domain protein
S100027_03610	COG1252	NADH dehydrogenase
S100027_03611	COG0492	ferredoxin-NADP+ reductase activity
S100027_03614	COG0456	acetyltransferase
S100027_03615	COG0316	Belongs to the HesB IscA family
S100027_03616	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S100027_03617	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100027_03618	COG4844	belongs to the
S100027_03619	COG1252	NADH dehydrogenase
S100027_03620	COG5646	InterPro IPR014922
S100027_03622	COG0457	Tetratricopeptide repeat
S100027_03623	COG3479	Phenolic acid decarboxylase
S100027_03625	COG4837	Protein of unknown function (DUF1462)
S100027_03626	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S100027_03627	COG4946	Tricorn protease homolog
S100027_03627	COG1506	peptidase
S100027_03627	COG0823	Involved in the tonB-independent uptake of proteins
S100027_03628	COG0083	homoserine kinase activity
S100027_03629	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S100027_03630	COG0460	homoserine dehydrogenase
S100027_03632	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100027_03633	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100027_03634	COG0647	UMP catabolic process
S100027_03635	COG2445	Protein of unknown function DUF86
S100027_03636	COG4470	Protein conserved in bacteria
S100027_03639	COG0739	heme binding
S100027_03641	COG0733	neurotransmitter:sodium symporter activity
S100027_03643	COG3377	Domain of unknown function (DUF1805)
S100027_03644	COG0737	Belongs to the 5'-nucleotidase family
S100027_03645	COG0730	response to heat
S100027_03646	COG1801	Protein of unknown function DUF72
S100027_03648	COG3226	Transcriptional regulator
S100027_03650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S100027_03651	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100027_03652	COG2508	Transcriptional regulator
S100027_03653	COG2814	Major facilitator Superfamily
S100027_03654	COG1288	antiporter activity
S100027_03655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S100027_03656	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S100027_03657	COG2356	endonuclease I
S100027_03659	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100027_03663	COG0457	Tetratricopeptide repeat
S100027_03664	COG0719	Fe-S assembly protein
S100027_03665	COG0822	iron-sulfur transferase activity
S100027_03666	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100027_03667	COG0719	Fe-S assembly protein
S100027_03668	COG0396	ATPase activity
S100027_03670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S100027_03671	COG1464	Belongs to the NlpA lipoprotein family
S100027_03672	COG2011	ABC-type metal ion transport system permease component
S100027_03673	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S100027_03675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100027_03676	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S100027_03678	COG0509	glycine decarboxylation via glycine cleavage system
S100027_03679	COG1393	Belongs to the ArsC family
S100027_03680	COG1960	acyl-CoA dehydrogenase activity
S100027_03681	COG0183	Belongs to the thiolase family
S100027_03682	COG1250	3-hydroxyacyl-CoA dehydrogenase
S100027_03682	COG1024	Enoyl-CoA hydratase
S100027_03685	COG5577	PFAM Coat F domain
S100027_03688	COG1120	ATPase activity
S100027_03689	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100027_03690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100027_03691	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100027_03694	COG1686	Belongs to the peptidase S11 family
S100027_03695	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_03696	COG0783	Belongs to the Dps family
S100027_03697	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100027_03698	COG0745	RESPONSE REGULATOR receiver
S100027_03699	COG2770	Histidine kinase
S100027_03699	COG2205	protein histidine kinase activity
S100027_03701	COG1309	transcriptional regulator
S100027_03702	COG0114	fumarate hydratase activity
S100027_03704	COG0697	spore germination
S100027_03705	COG0814	amino acid
S100027_03708	COG2197	response regulator
S100027_03709	COG4585	Histidine kinase
S100027_03710	COG4758	membrane
S100027_03712	COG1842	Phage shock protein A
S100027_03713	COG4758	membrane
S100027_03714	COG4677	pectinesterase activity
S100027_03715	COG2096	Adenosyltransferase
S100027_03716	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_03717	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
S100027_03718	COG1454	alcohol dehydrogenase
S100027_03719	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100027_03720	COG1120	ATPase activity
S100027_03721	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100027_03722	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100027_03723	COG1802	Transcriptional regulator
S100027_03724	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_03725	COG2258	MOSC domain
S100027_03726	COG0583	DNA-binding transcription factor activity
S100027_03728	COG2721	sulfolactate sulfo-lyase activity
S100027_03729	COG0246	Mannitol dehydrogenase
S100027_03730	COG1609	Transcriptional regulator
S100027_03731	COG2211	Major facilitator Superfamily
S100027_03732	COG1904	glucuronate isomerase
S100027_03733	COG2205	protein histidine kinase activity
S100027_03734	COG0745	RESPONSE REGULATOR receiver
S100027_03735	COG1120	ATPase activity
S100027_03736	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100027_03737	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100027_03738	COG0531	amino acid
S100027_03739	COG1988	membrane-bound metal-dependent
S100027_03740	COG1368	sulfuric ester hydrolase activity
S100027_03741	COG2814	Major facilitator Superfamily
S100027_03742	COG0656	L-ascorbic acid biosynthetic process
S100027_03743	COG1940	carbohydrate kinase activity
S100027_03744	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100027_03746	COG3973	AAA domain
S100027_03747	COG2860	membrane
S100027_03748	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S100027_03748	COG0456	acetyltransferase
S100027_03750	COG0456	acetyltransferase
S100027_03751	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S100027_03752	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S100027_03753	COG2217	Heavy metal translocating P-type atpase
S100027_03754	COG1653	transport
S100027_03755	COG1175	transmembrane transport
S100027_03756	COG0395	ABC-type sugar transport system, permease component
S100027_03757	COG1501	Belongs to the glycosyl hydrolase 31 family
S100027_03758	COG1472	Belongs to the glycosyl hydrolase 3 family
S100027_03759	COG1121	(ABC) transporter
S100027_03760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100027_03761	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100027_03766	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100027_03766	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100027_03766	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100027_03770	COG2217	Heavy metal translocating P-type atpase
S100027_03771	COG2608	mercury ion transmembrane transporter activity
S100027_03772	COG1937	Protein conserved in bacteria
S100027_03773	COG0693	protein deglycase activity
S100027_03774	COG1349	DNA-binding transcription factor activity
S100027_03775	COG1070	Carbohydrate kinase
S100027_03776	COG4952	isomerase
S100027_03778	COG3347	Dehydrogenase
S100027_03778	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_03779	COG2814	Major facilitator Superfamily
S100027_03781	COG2814	Major facilitator Superfamily
S100027_03783	COG2124	cytochrome p450
S100027_03785	COG1846	Transcriptional regulator
S100027_03787	COG0154	amidase activity
S100027_03788	COG0673	inositol 2-dehydrogenase activity
S100027_03789	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100027_03793	COG1191	sigma factor activity
S100027_03795	COG2140	Oxalate decarboxylase
S100027_03802	COG5444	nuclease activity
S100027_03805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S100027_03806	COG0557	exoribonuclease II activity
S100027_03807	COG1647	Serine aminopeptidase, S33
S100027_03808	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S100027_03809	COG2002	toxin-antitoxin pair type II binding
S100027_03810	COG1476	TRANSCRIPTIONal
S100027_03811	COG1396	sequence-specific DNA binding
S100027_03812	COG1396	sequence-specific DNA binding
S100027_03813	COG1174	glycine betaine transport
S100027_03814	COG1732	Glycine betaine
S100027_03815	COG1174	glycine betaine transport
S100027_03816	COG0517	IMP dehydrogenase activity
S100027_03816	COG1125	glycine betaine transport
S100027_03817	COG1510	regulation of RNA biosynthetic process
S100027_03818	COG2095	MarC family integral membrane protein
S100027_03819	COG3064	Membrane
S100027_03820	COG4640	response to antibiotic
S100027_03822	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100027_03824	COG0693	protein deglycase activity
S100027_03825	COG0148	phosphopyruvate hydratase activity
S100027_03826	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S100027_03827	COG0149	triose-phosphate isomerase activity
S100027_03828	COG0126	phosphoglycerate kinase activity
S100027_03829	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S100027_03830	COG2390	Transcriptional regulator
S100027_03831	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100027_03832	COG1113	amino acid transport
S100027_03834	COG1131	(ABC) transporter
S100027_03836	COG1556	Lactate utilization protein
S100027_03837	COG1139	Iron-sulfur cluster binding protein
S100027_03838	COG0247	lactate metabolic process
S100027_03839	COG2186	Transcriptional regulator
S100027_03840	COG1620	l-lactate permease
S100027_03841	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S100027_03843	COG5039	Polysaccharide pyruvyl transferase
S100027_03844	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100027_03845	COG0110	maltose O-acetyltransferase activity
S100027_03846	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S100027_03847	COG2244	polysaccharide biosynthetic process
S100027_03848	COG1216	Glycosyl transferase, family 2
S100027_03849	COG5039	Polysaccharide pyruvyl transferase
S100027_03850	COG1216	Glycosyl transferase, family 2
S100027_03852	COG0438	transferase activity, transferring glycosyl groups
S100027_03853	COG1215	transferase activity, transferring glycosyl groups
S100027_03854	COG0438	transferase activity, transferring glycosyl groups
S100027_03855	COG1086	Polysaccharide biosynthesis protein
S100027_03856	COG0489	protein tyrosine kinase activity
S100027_03857	COG3944	biosynthesis protein
S100027_03858	COG1396	sequence-specific DNA binding
S100027_03859	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100027_03860	COG2271	Major facilitator Superfamily
S100027_03862	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
S100027_03865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100027_03867	COG1733	regulation of RNA biosynthetic process
S100027_03868	COG1902	pentaerythritol trinitrate reductase activity
S100027_03869	COG1621	beta-fructofuranosidase activity
S100027_03870	COG1621	beta-fructofuranosidase activity
S100027_03873	COG0740	serine-type endopeptidase activity
S100027_03874	COG1611	Belongs to the LOG family
S100027_03875	COG1694	Mazg nucleotide pyrophosphohydrolase
S100027_03876	COG1078	dGTPase activity
S100027_03877	COG0659	secondary active sulfate transmembrane transporter activity
S100027_03878	COG0288	reversible hydration of carbon dioxide
S100027_03879	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100027_03880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S100027_03881	COG0640	Transcriptional regulator
S100027_03883	COG2732	(Barnase) inhibitor
S100027_03884	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S100027_03885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100027_03886	COG1481	regulation of sporulation
S100027_03887	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S100027_03888	COG1660	Displays ATPase and GTPase activities
S100027_03889	COG1051	belongs to the nudix hydrolase family
S100027_03890	COG0492	ferredoxin-NADP+ reductase activity
S100027_03891	COG0457	Tetratricopeptide repeat
S100027_03892	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100027_03893	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S100027_03893	COG0140	phosphoribosyl-ATP diphosphatase activity
S100027_03894	COG0107	imidazoleglycerol-phosphate synthase activity
S100027_03895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S100027_03896	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S100027_03897	COG0131	Imidazoleglycerol-phosphate dehydratase
S100027_03898	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S100027_03899	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S100027_03900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S100027_03901	COG4990	cell redox homeostasis
S100027_03902	COG5297	Belongs to the glycosyl hydrolase family 6
S100027_03903	COG0110	maltose O-acetyltransferase activity
S100027_03904	COG0546	phosphoglycolate phosphatase activity
S100027_03905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
S100027_03906	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S100027_03907	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S100027_03908	COG1846	Transcriptional regulator
S100027_03909	COG2814	Major facilitator Superfamily
S100027_03910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S100027_03911	COG1950	PFAM Membrane protein of
S100027_03912	COG1983	PspC domain protein
S100027_03913	COG3595	metallopeptidase activity
S100027_03917	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S100027_03918	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S100027_03919	COG0556	nucleotide-excision repair
S100027_03920	COG4897	Protein conserved in bacteria
S100027_03922	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100027_03924	COG3409	Peptidoglycan-binding domain 1 protein
S100027_03924	COG0793	Belongs to the peptidase S41A family
S100027_03925	COG0473	3-isopropylmalate dehydrogenase activity
S100027_03926	COG0791	NLP P60 protein
S100027_03926	COG3883	PFAM NLP P60 protein
S100027_03927	COG2177	Part of the ABC transporter FtsEX involved in
S100027_03928	COG2884	Cell division ATP-binding protein ftsE
S100027_03929	COG2010	Cytochrome c
S100027_03930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100027_03931	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
S100027_03932	COG0653	protein targeting
S100027_03933	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S100027_03936	COG1516	flagellar protein fliS
S100027_03937	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S100027_03938	COG1334	flagellar protein FlaG
S100027_03939	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100027_03940	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
S100027_03941	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
S100027_03943	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100027_03944	COG4786	Flagellar basal body rod
S100027_03944	COG1256	bacterial-type flagellum assembly
S100027_03945	COG3418	PFAM FlgN family protein
S100027_03946	COG2747	anti-sigma28 factor FlgM
S100027_03949	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S100027_03950	COG1307	EDD domain protein, DegV family
S100027_03951	COG2197	response regulator
S100027_03952	COG4585	Histidine kinase
S100027_03953	COG1739	Uncharacterized protein family UPF0029
S100027_03954	COG1316	TRANSCRIPTIONal
S100027_03956	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100027_03957	COG0438	transferase activity, transferring glycosyl groups
S100027_03958	COG1215	transferase activity, transferring glycosyl groups
S100027_03959	COG3206	protein involved in exopolysaccharide biosynthesis
S100027_03960	COG3307	-O-antigen
S100027_03961	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100027_03962	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S100027_03963	COG0438	transferase activity, transferring glycosyl groups
S100027_03963	COG0297	glycogen (starch) synthase activity
S100027_03964	COG2244	polysaccharide biosynthetic process
S100027_03966	COG2247	cell wall binding repeat
S100027_03966	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100027_03967	COG2247	cell wall binding repeat
S100027_03967	COG2385	sporulation resulting in formation of a cellular spore
S100027_03969	COG1316	TRANSCRIPTIONal
S100027_03970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S100027_03971	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100027_03972	COG1134	teichoic acid transport
S100027_03973	COG1682	transport, permease protein
S100027_03975	COG0463	Glycosyl transferase, family 2
S100027_03975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100027_03976	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100027_03977	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S100027_03978	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
S100027_03979	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100027_03980	COG4193	domain, Protein
S100027_03981	COG1482	cell wall glycoprotein biosynthetic process
S100027_03985	COG0800	Aldolase
S100027_03986	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100027_03987	COG1609	Transcriptional regulator
S100027_03988	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
S100027_03989	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_03990	COG1063	alcohol dehydrogenase
S100027_03992	COG2814	Major facilitator Superfamily
S100027_03993	COG1316	TRANSCRIPTIONal
S100027_03994	COG0561	phosphatase activity
S100027_03995	COG0791	NLP P60 protein
S100027_03997	COG2843	Capsule synthesis protein
S100027_03999	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100027_04000	COG1609	Transcriptional regulator
S100027_04001	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100027_04002	COG1869	D-ribose catabolic process
S100027_04003	COG1129	ABC transporter
S100027_04004	COG1172	Belongs to the binding-protein-dependent transport system permease family
S100027_04005	COG1879	ABC-type sugar transport system periplasmic component
S100027_04006	COG3527	Alpha-acetolactate decarboxylase
S100027_04007	COG0028	Belongs to the TPP enzyme family
S100027_04008	COG0583	DNA-binding transcription factor activity
S100027_04010	COG2801	Transposase and inactivated derivatives
S100027_04011	COG0405	Gamma-glutamyltransferase
S100027_04012	COG1522	sequence-specific DNA binding
S100027_04013	COG2059	Chromate
S100027_04014	COG2059	Chromate
S100027_04015	COG4464	protein tyrosine phosphatase activity
S100027_04016	COG3944	biosynthesis protein
S100027_04018	COG4715	Zinc finger, swim domain protein
S100027_04019	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S100027_04021	COG0561	phosphatase activity
S100027_04022	COG1349	DNA-binding transcription factor activity
S100027_04024	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_04026	COG3732	PTS system glucitol sorbitol-specific
S100027_04030	COG0629	single-stranded DNA binding
S100027_04033	COG1970	mechanosensitive ion channel activity
S100027_04034	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100027_04035	COG4786	Flagellar basal body rod
S100027_04036	COG4786	Flagellar basal body rod
S100027_04037	COG1077	Cell shape determining protein MreB Mrl
S100027_04038	COG1609	Transcriptional regulator
S100027_04039	COG1846	Transcriptional regulator
S100027_04040	COG2814	Major facilitator Superfamily
S100027_04041	COG0671	phosphoesterase, PA-phosphatase related
S100027_04042	COG1227	inorganic diphosphatase activity
S100027_04043	COG3546	catalase activity
S100027_04044	COG3361	conserved protein (COG2071)
S100027_04045	COG0517	IMP dehydrogenase activity
S100027_04046	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S100027_04047	COG0598	Magnesium transport protein CorA
S100027_04048	COG1253	flavin adenine dinucleotide binding
S100027_04049	COG0004	ammonium transporteR
S100027_04050	COG0347	Belongs to the P(II) protein family
S100027_04051	COG0740	serine-type endopeptidase activity
S100027_04053	COG0739	heme binding
S100027_04054	COG1247	-acetyltransferase
S100027_04056	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100027_04058	COG0477	Major facilitator Superfamily
S100027_04059	COG3251	PFAM MbtH domain protein
S100027_04060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100027_04061	COG1535	isochorismatase
S100027_04061	COG3433	isochorismatase activity
S100027_04062	COG1021	2,3-dihydroxybenzoate-AMP ligase
S100027_04063	COG1169	isochorismate synthase
S100027_04064	COG1028	Short-chain dehydrogenase reductase Sdr
S100027_04065	COG2819	hydrolase of the alpha beta superfamily
S100027_04066	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100027_04067	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100027_04068	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100027_04069	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100027_04069	COG2207	Transcriptional regulator
S100027_04071	COG2910	NAD(P)H-binding
S100027_04072	COG1959	2 iron, 2 sulfur cluster binding
S100027_04074	COG1994	Peptidase M50
S100027_04075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S100027_04076	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S100027_04078	COG3383	formate dehydrogenase (NAD+) activity
S100027_04079	COG2304	oxidoreductase activity
S100027_04080	COG2304	oxidoreductase activity
S100027_04081	COG2385	sporulation resulting in formation of a cellular spore
S100027_04082	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100027_04084	COG4836	Membrane
S100027_04085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S100027_04086	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S100027_04087	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S100027_04088	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S100027_04089	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100027_04090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S100027_04091	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100027_04094	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S100027_04095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S100027_04096	COG4475	Protein of unknown function (DUF436)
S100027_04097	COG0698	ribose 5-phosphate isomerase
S100027_04098	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100027_04099	COG1971	Probably functions as a manganese efflux pump
S100027_04100	COG0009	L-threonylcarbamoyladenylate synthase
S100027_04101	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S100027_04103	COG0738	Major facilitator superfamily
S100027_04104	COG0673	inositol 2-dehydrogenase activity
S100027_04105	COG0561	phosphatase activity
S100027_04106	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100027_04107	COG1609	Transcriptional regulator
S100027_04108	COG2890	protein-(glutamine-N5) methyltransferase activity
S100027_04109	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S100027_04110	COG0346	lactoylglutathione lyase activity
S100027_04111	COG0789	Transcriptional regulator
S100027_04112	COG0679	Auxin Efflux Carrier
S100027_04113	COG0281	malic enzyme
S100027_04114	COG1435	thymidine kinase activity
S100027_04115	COG0254	rRNA binding
S100027_04116	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S100027_04117	COG1494	fructose-1,6-bisphosphatase
S100027_04118	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100027_04119	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S100027_04120	COG0191	fructose-bisphosphate aldolase activity
S100027_04121	COG2204	response regulator
S100027_04122	COG4821	SIS domain
S100027_04124	COG2801	Transposase and inactivated derivatives
S100027_04125	COG0504	CTP synthase activity
S100027_04126	COG3343	RNA polymerase activity
S100027_04127	COG1960	acyl-CoA dehydrogenase activity
S100027_04128	COG1960	acyl-CoA dehydrogenase activity
S100027_04129	COG1250	3-hydroxyacyl-CoA dehydrogenase
S100027_04130	COG0183	Belongs to the thiolase family
S100027_04131	COG2181	nitrate reductase activity
S100027_04131	COG0247	lactate metabolic process
S100027_04132	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100027_04134	COG0018	arginyl-trna synthetase
S100027_04135	COG4506	Protein conserved in bacteria
S100027_04136	COG0010	Belongs to the arginase family
S100027_04137	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S100027_04139	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100027_04141	COG1994	Peptidase M50
S100027_04142	COG1942	4-Oxalocrotonate Tautomerase
S100027_04144	COG3465	dGTPase activity
S100027_04145	COG1078	dGTPase activity
S100027_04146	COG4844	belongs to the
S100027_04151	COG2814	Major facilitator Superfamily
S100027_04156	COG1414	Transcriptional regulator
S100027_04158	COG0280	phosphate acetyltransferase
S100027_04161	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100027_04165	COG1131	(ABC) transporter
S100027_04168	COG2363	Small membrane protein
S100027_04169	COG2233	PERMEase
S100027_04171	COG1012	belongs to the aldehyde dehydrogenase family
S100027_04172	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S100027_04173	COG1216	Glycosyl transferase, family 2
S100027_04174	COG0351	phosphomethylpyrimidine kinase
S100027_04176	COG1621	beta-fructofuranosidase activity
S100027_04177	COG1263	PTS System
S100027_04177	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_04178	COG3711	transcriptional antiterminator
S100027_04180	COG1404	Belongs to the peptidase S8 family
S100027_04182	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100027_04184	COG0778	Nitroreductase
S100027_04185	COG1473	amidohydrolase
S100027_04186	COG0772	Belongs to the SEDS family
S100027_04187	COG0772	Belongs to the SEDS family
S100027_04193	COG0456	acetyltransferase
S100027_04201	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S100027_04203	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S100027_04204	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S100027_04205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100027_04209	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100027_04210	COG3162	membrane
S100027_04211	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100027_04212	COG1070	Carbohydrate kinase
S100027_04213	COG2115	Belongs to the xylose isomerase family
S100027_04215	COG0352	thiamine-phosphate diphosphorylase activity
S100027_04216	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S100027_04217	COG0583	DNA-binding transcription factor activity
S100027_04220	COG1380	Effector of murein hydrolase LrgA
S100027_04221	COG1346	cytolysis
S100027_04223	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100027_04224	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S100027_04225	COG0346	lactoylglutathione lyase activity
S100027_04226	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100027_04227	COG1442	glycosyl transferase family 8
S100027_04230	COG4585	Histidine kinase
S100027_04231	COG2197	response regulator
S100027_04232	COG2409	Drug exporters of the RND superfamily
S100027_04233	COG5522	Integral membrane protein (intg_mem_TP0381)
S100027_04234	COG2271	Major facilitator Superfamily
S100027_04235	COG4948	Mandelate Racemase Muconate Lactonizing
S100027_04236	COG0800	Aldolase
S100027_04237	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100027_04239	COG2234	aminopeptidase activity
S100027_04240	COG0477	Major facilitator Superfamily
S100027_04242	COG2357	RelA SpoT domain protein
S100027_04245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100027_04246	COG1696	Membrane protein involved in D-alanine export
S100027_04247	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100027_04248	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S100027_04249	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100027_04250	COG2814	Major facilitator Superfamily
S100027_04251	COG1486	melibiose metabolic process
S100027_04252	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100027_04253	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100027_04254	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100027_04255	COG3711	transcriptional antiterminator
S100027_04255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100027_04257	COG2094	Belongs to the DNA glycosylase MPG family
S100027_04259	COG0372	Belongs to the citrate synthase family
S100027_04260	COG2079	MmgE PrpD family protein
S100027_04261	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S100027_04264	COG1132	(ABC) transporter
S100027_04265	COG2755	lipolytic protein G-D-S-L family
S100027_04268	COG2814	Major facilitator Superfamily
S100027_04269	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100027_04270	COG1131	(ABC) transporter
S100027_04274	COG1595	DNA-templated transcription, initiation
S100027_04275	COG2814	Major facilitator Superfamily
S100027_04276	COG0753	catalase activity
S100027_04277	COG0753	catalase activity
S100027_04278	COG0735	belongs to the Fur family
S100027_04280	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100027_04281	COG1131	(ABC) transporter
S100027_04284	COG1131	(ABC) transporter
S100027_04294	COG3866	Pectate lyase
S100027_04295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S100027_04296	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S100027_04297	COG4988	ABC transporter
S100027_04298	COG1294	oxidase, subunit
S100027_04299	COG1271	oxidase subunit
S100027_04300	COG2116	formate transmembrane transporter activity
S100027_04302	COG0281	malic enzyme
S100027_04303	COG1757	Na H antiporter
S100027_04304	COG1027	Aspartate ammonia-lyase
S100027_04305	COG0252	asparaginase activity
S100027_04306	COG1396	sequence-specific DNA binding
S100027_04307	COG2706	6-phosphogluconolactonase activity
S100027_04308	COG0745	RESPONSE REGULATOR receiver
S100027_04309	COG2205	protein histidine kinase activity
S100027_04310	COG1136	(ABC) transporter
S100027_04311	COG0577	efflux transmembrane transporter activity
S100027_04312	COG5294	Protein conserved in bacteria
S100027_04315	COG0726	polysaccharide deacetylase
S100027_04316	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100027_04317	COG1215	transferase activity, transferring glycosyl groups
S100027_04319	COG2801	Transposase and inactivated derivatives
S100027_04320	COG3493	citrate carrier protein
S100027_04321	COG0584	glycerophosphoryl diester phosphodiesterase
S100027_04324	COG1368	sulfuric ester hydrolase activity
S100027_04326	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100027_04328	COG2235	arginine
S100027_04329	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S100027_04331	COG0549	Belongs to the carbamate kinase family
S100027_04333	COG2723	6-phospho-beta-galactosidase activity
S100027_04334	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100027_04336	COG1595	DNA-templated transcription, initiation
S100027_04341	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S100027_04342	COG2195	Cleaves the N-terminal amino acid of tripeptides
S100027_04343	COG1621	beta-fructofuranosidase activity
S100027_04344	COG2223	nitrite transmembrane transporter activity
S100027_04345	COG1609	Transcriptional regulator
S100027_04349	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100027_04350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S100027_04351	COG0463	Glycosyl transferase, family 2
S100027_04352	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100027_04357	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100027_04358	COG0693	protein deglycase activity
S100027_04358	COG0753	catalase activity
S100027_04359	COG0753	catalase activity
S100027_04359	COG0693	protein deglycase activity
S100027_04361	COG2723	6-phospho-beta-galactosidase activity
S100027_04362	COG2190	(PTS) system
S100027_04362	COG1263	PTS System
S100027_04362	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_04363	COG3711	transcriptional antiterminator
S100027_04364	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100027_04365	COG1122	ATPase activity
S100027_04366	COG4721	ABC-type cobalt transport system, permease component
S100027_04367	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S100027_04369	COG2224	Isocitrate lyase
S100027_04370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
S100027_04372	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S100027_04373	COG0577	efflux transmembrane transporter activity
S100027_04374	COG1136	(ABC) transporter
S100027_04375	COG2205	protein histidine kinase activity
S100027_04376	COG0745	RESPONSE REGULATOR receiver
S100027_04377	COG2723	6-phospho-beta-galactosidase activity
S100027_04378	COG2190	(PTS) system
S100027_04378	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_04378	COG1263	PTS System
S100027_04380	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S100027_04383	COG3507	Belongs to the glycosyl hydrolase 43 family
S100027_04389	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S100027_04390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100027_04391	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S100027_04392	COG2390	Transcriptional regulator
S100027_04394	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
S100027_04395	COG3706	GGDEF domain
S100027_04396	COG5298	Protein conserved in bacteria
S100027_04397	COG5298	Protein conserved in bacteria
S100027_04398	COG1215	transferase activity, transferring glycosyl groups
S100027_04400	COG3977	Valine--pyruvate aminotransferase
S100027_04403	COG1181	Belongs to the D-alanine--D-alanine ligase family
S100027_04405	COG0191	fructose-bisphosphate aldolase activity
S100027_04406	COG1082	Xylose isomerase domain protein TIM barrel
S100027_04407	COG1082	Xylose isomerase domain protein TIM barrel
S100027_04408	COG0673	inositol 2-dehydrogenase activity
S100027_04409	COG2814	Major facilitator Superfamily
S100027_04410	COG1082	Xylose isomerase domain protein TIM barrel
S100027_04411	COG3962	Belongs to the TPP enzyme family
S100027_04412	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100027_04413	COG3718	enzyme involved in inositol metabolism
S100027_04414	COG1012	belongs to the aldehyde dehydrogenase family
S100027_04415	COG1349	DNA-binding transcription factor activity
S100027_04416	COG0667	Aldo Keto reductase
S100027_04417	COG0584	glycerophosphoryl diester phosphodiesterase
S100027_04418	COG2271	Major facilitator Superfamily
S100027_04419	COG0326	Molecular chaperone. Has ATPase activity
S100027_04420	COG0488	(ABC) transporter
S100027_04421	COG0561	phosphatase activity
S100027_04426	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100027_04431	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
S100027_04432	COG0577	efflux transmembrane transporter activity
S100027_04433	COG1136	(ABC) transporter
S100027_04434	COG2205	protein histidine kinase activity
S100027_04435	COG0745	RESPONSE REGULATOR receiver
S100027_04437	COG0840	transmembrane signaling receptor activity
S100027_04437	COG5278	phosphoserine phosphatase activity
S100027_04438	COG1115	amino acid carrier protein
S100027_04439	COG0686	Belongs to the AlaDH PNT family
S100027_04440	COG3867	Arabinogalactan endo-beta-1,4-galactanase
S100027_04441	COG1874	Beta-galactosidase
S100027_04442	COG3833	ABC-type maltose transport systems, permease component
S100027_04443	COG1175	transmembrane transport
S100027_04444	COG2182	Extracellular solute-binding protein
S100027_04445	COG1609	Transcriptional regulator
S100027_04447	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100027_04448	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S100027_04449	COG1940	carbohydrate kinase activity
S100027_04454	COG1454	alcohol dehydrogenase
S100027_04454	COG1012	belongs to the aldehyde dehydrogenase family
S100027_04455	COG0450	alkyl hydroperoxide reductase
S100027_04456	COG3634	alkyl hydroperoxide reductase activity
S100027_04461	COG1131	(ABC) transporter
S100027_04462	COG0842	Transport permease protein
S100027_04463	COG4585	Histidine kinase
S100027_04464	COG4585	Histidine kinase
S100027_04465	COG2197	response regulator
S100027_04471	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S100027_04474	COG0456	acetyltransferase
S100027_04477	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100027_04478	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S100027_04479	COG4853	Protein conserved in bacteria
S100027_04480	COG4863	YycH protein
S100027_04481	COG5002	protein histidine kinase activity
S100027_04482	COG0745	RESPONSE REGULATOR receiver
S100027_04487	COG1051	belongs to the nudix hydrolase family
S100027_04488	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S100027_04490	COG0305	Participates in initiation and elongation during chromosome replication
S100027_04493	COG3093	addiction module antidote protein HigA
S100027_04494	COG2807	transmembrane transport
S100027_04495	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S100027_04496	COG0363	glucosamine-6-phosphate deaminase activity
S100027_04498	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S100027_04499	COG1263	PTS System
S100027_04499	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100027_04500	COG0359	binds to the 23S rRNA
S100027_04501	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
S100027_04502	COG4241	membrane
S100027_04503	COG5577	PFAM Coat F domain
S100027_04504	COG0589	response to stress
S100027_04505	COG0659	secondary active sulfate transmembrane transporter activity
S100027_04506	COG2271	Major facilitator Superfamily
S100027_04507	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S100027_04508	COG0629	single-stranded DNA binding
S100027_04509	COG0360	Binds together with S18 to 16S ribosomal RNA
S100027_04510	COG0012	GTP binding
S100027_04511	COG4481	Protein conserved in bacteria
S100027_04512	COG3949	Membrane
S100027_04514	COG1475	DNA binding
S100027_04515	COG1192	Involved in chromosome partitioning
S100027_04516	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S100027_04518	COG1475	DNA binding
S100027_04519	COG0357	Ribosomal RNA small subunit methyltransferase G
S100027_04520	COG0445	tRNA wobble uridine modification
S100027_04521	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S100027_04522	COG1847	R3H domain protein
S100027_04523	COG0706	membrane insertase activity
S100027_04524	COG0594	ribonuclease P activity
S100027_04526	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S100027_04527	COG0789	Transcriptional regulator
S100027_04528	COG1664	Polymer-forming cytoskeletal
S100027_04530	COG2766	serine protein kinase
S100027_04531	COG2718	Belongs to the UPF0229 family
S100027_04534	COG4974	Belongs to the 'phage' integrase family
S100027_04553	COG0457	Tetratricopeptide repeat
S100027_04555	COG5444	nuclease activity
S100027_04559	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S100027_04565	COG4195	phage-related replication protein
S100027_04566	COG3420	alginic acid biosynthetic process
S100027_04566	COG5434	Belongs to the glycosyl hydrolase 28 family
S100027_04570	COG2131	deaminase
S100027_04571	COG2002	toxin-antitoxin pair type II binding
S100027_04600	COG0741	lytic transglycosylase activity
S100027_04600	COG0739	heme binding
S100027_04600	COG1196	nuclear chromosome segregation
S100027_04607	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100027_04613	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100027_04615	COG2176	DNA-directed DNA polymerase activity
S100027_04620	COG0194	GDP metabolic process
S100027_04626	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S100027_04632	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100027_04633	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100027_04639	COG1566	PFAM secretion protein HlyD family protein
S100027_04640	COG2814	Major facilitator Superfamily
S100027_04641	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100027_04643	COG1131	(ABC) transporter
S100027_04644	COG1131	(ABC) transporter
S100027_04645	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100027_04646	COG2801	Transposase and inactivated derivatives
S100027_04648	COG1278	Cold shock
S100027_04649	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S100027_04650	COG2011	ABC-type metal ion transport system permease component
S100027_04651	COG1464	Belongs to the NlpA lipoprotein family
S100027_04652	COG1823	symporter activity
S100027_04653	COG1823	symporter activity
S100027_04662	COG3409	Peptidoglycan-binding domain 1 protein
S100027_04662	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100027_04666	COG0438	transferase activity, transferring glycosyl groups
S100027_04670	COG4974	Belongs to the 'phage' integrase family