locus-tag class description S100141_00001 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component S100141_00002 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component S100141_00003 ENOG4108KPW sugar kinase S100141_00004 ENOG4108KPW sugar kinase S100141_00005 ENOG4105FDP GntR family transcriptional regulator S100141_00006 ENOG4108IJ9 (ABC) transporter S100141_00007 ENOG4108K8S endonuclease I S100141_00009 ENOG4105C5R Aminotransferase S100141_00013 ENOG4106129 S100141_00014 ENOG4105G9B Transcriptional regulator S100141_00015 ENOG4105G9B Transcriptional regulator S100141_00016 ENOG4105CD3 dihydroorotase S100141_00018 ENOG4105I3N Conserved Protein S100141_00020 ENOG4107R8B 5'-nucleotidase S100141_00021 ENOG4108YTE sporulation protein YunB S100141_00022 ENOG4105FAA peptidase M23 S100141_00023 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) S100141_00024 ENOG4105MMD transcriptional regulator S100141_00026 ENOG4105D4U had-superfamily hydrolase, subfamily iia S100141_00027 ENOG4108W5N phosphatidylglycerophosphatase a S100141_00029 ENOG4105D6E homoserine dehydrogenase S100141_00030 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) S100141_00031 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) S100141_00032 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein S100141_00033 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein S100141_00034 ENOG41083MR nifu domain-containing protein S100141_00037 ENOG4105ZKE UPF0349 protein S100141_00039 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) S100141_00040 ENOG4108YX9 iron--sulfur cluster insertion protein erpA S100141_00041 ENOG4108VHC Short-chain dehydrogenase reductase Sdr S100141_00042 ENOG4105D9U N-acetyltransferase S100141_00046 ENOG4105CJ1 ABC, transporter S100141_00049 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) S100141_00052 ENOG4105CEP NADH dehydrogenase S100141_00053 ENOG4105CEP NADH dehydrogenase S100141_00055 ENOG41069ER domain protein S100141_00057 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) S100141_00061 ENOG4105NIV Esterase S100141_00062 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase S100141_00063 ENOG4105E4F Isochorismate synthase S100141_00064 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase S100141_00065 ENOG4105WQI isochorismatase S100141_00066 ENOG4105CEY Amp-dependent synthetase and ligase S100141_00067 ENOG4105WQT MbtH domain protein S100141_00069 ENOG4105DCF alanine dehydrogenase S100141_00070 ENOG4108K8K Transcriptional regulator S100141_00079 ENOG410904N short-chain dehydrogenase reductase S100141_00082 ENOG4105C02 permease S100141_00087 ENOG4105DAP Nicotinate phosphoribosyltransferase S100141_00088 ENOG4105D58 Diguanylate phosphodiesterase S100141_00093 ENOG4105BZU Histidine kinase S100141_00095 ENOG4105KA0 thioesterase Superfamily protein S100141_00096 ENOG4105KJM monovalent cation h antiporter subunit g S100141_00098 ENOG4105SC1 monovalent cation H antiporter subunit E S100141_00099 ENOG4108JPZ Monovalent cation H antiporter subunit D S100141_00100 ENOG4108ZE9 Monovalent cation H antiporter subunit C S100141_00101 ENOG4105HC0 Na H antiporter S100141_00102 ENOG4105D65 subunit l S100141_00105 ENOG4105UIB (ABC) transporter S100141_00106 ENOG4108JQ9 ABC transporter S100141_00107 ENOG4105DIH basic membrane S100141_00108 ENOG4108MRH transcriptional regulatory protein S100141_00111 ENOG4105KIR Thiol-disulfide oxidoreductase dcc S100141_00112 ENOG4105BZ4 penicillin-binding protein S100141_00115 ENOG4105Y38 Kinase-associated protein B S100141_00116 ENOG4108HGU Histidine kinase S100141_00117 ENOG4108HGU Histidine kinase S100141_00118 ENOG4105C87 Aminotransferase class I and II S100141_00120 ENOG4108MUZ hydrolase S100141_00121 ENOG4108ZB6 transcriptional regulator AsnC family S100141_00122 ENOG4105CHM Aminotransferase S100141_00124 ENOG4105WG9 Conserved Protein S100141_00125 ENOG4107QW4 alcohol dehydrogenase S100141_00128 ENOG4105CHJ isochorismatase hydrolase S100141_00130 ENOG4107QYV phosphohexose isomerase S100141_00133 ENOG4107PBV potassium channel S100141_00134 ENOG4107PBV potassium channel S100141_00138 ENOG4105C37 (CBS) domain S100141_00140 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme S100141_00141 ENOG4105EA8 2-Nitropropane dioxygenase S100141_00144 ENOG4105C8Q Methyl-accepting chemotaxis S100141_00145 ENOG4105C8Q Methyl-accepting chemotaxis S100141_00146 ENOG4105C8Q Methyl-accepting chemotaxis S100141_00147 ENOG4105C8Q Methyl-accepting chemotaxis S100141_00148 ENOG4105C8Q Methyl-accepting chemotaxis S100141_00149 ENOG4105C8Q Methyl-accepting chemotaxis S100141_00150 ENOG4108Z0Z intracellular protease Pfpi family S100141_00151 ENOG4105EE0 oxidoreductase S100141_00153 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) S100141_00155 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S100141_00157 ENOG4106BHF S100141_00162 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) S100141_00163 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) S100141_00164 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj S100141_00167 ENOG4105TRT Transcriptional regulator S100141_00168 ENOG4105C26 Dehydrogenase S100141_00169 ENOG4108JB8 alcohol dehydrogenase S100141_00170 ENOG4108VNY MOSC domain protein S100141_00171 ENOG4106DF1 S100141_00173 ENOG4105DZ6 Band 7 protein S100141_00174 ENOG4105N67 Proton-coupled thiamine transporter YuaJ S100141_00193 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S100141_00223 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) S100141_00229 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) S100141_00230 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S100141_00232 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S100141_00233 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) S100141_00240 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the S100141_00258 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S100141_00268 ENOG4108FKH Transglycosylase SLT domain S100141_00272 ENOG41068G1 S100141_00276 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S100141_00280 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) S100141_00285 ENOG410780I phosphoprotein phosphatase activity S100141_00291 ENOG4107EV6 Inherit from COG: YD repeat protein S100141_00295 ENOG4107EV6 Inherit from COG: YD repeat protein S100141_00297 ENOG4105C22 threonyL-tRNA synthetase S100141_00298 ENOG4105FF2 Type I DHQase S100141_00299 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) S100141_00300 ENOG4105D7T ABC transporter S100141_00301 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein S100141_00302 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component S100141_00303 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) S100141_00304 ENOG4107D63 S100141_00305 ENOG4105VZ8 Transcriptional regulator S100141_00307 ENOG4105DA5 (ABC) transporter S100141_00311 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) S100141_00314 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) S100141_00316 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) S100141_00320 ENOG4105CYN Serine protein kinase S100141_00321 ENOG4106AKX UPF0229 protein S100141_00324 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S100141_00344 ENOG4107EV6 Inherit from COG: YD repeat protein S100141_00348 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) S100141_00355 ENOG4105K7W phage-related replication protein S100141_00360 ENOG4108KU1 UPF0736 protein S100141_00361 ENOG4108UK2 deaminase S100141_00391 ENOG4105E4C Lytic transglycosylase catalytic S100141_00398 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase S100141_00404 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) S100141_00410 ENOG4105BZ1 (ABC) transporter S100141_00416 ENOG4108IAB Phoh family S100141_00422 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S100141_00423 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S100141_00429 ENOG4105CW7 secretion protein, HlyD family S100141_00430 ENOG4105C0R drug resistance transporter emrb qaca subfamily S100141_00431 ENOG4105CS1 NAD(P)H quinone oxidoreductase S100141_00433 ENOG4105CZV ABC transporter S100141_00434 ENOG4105CJ1 ABC, transporter S100141_00435 ENOG4108TU7 Inherit from COG: (ABC) transporter S100141_00436 ENOG4105DQ6 Transposase S100141_00438 ENOG4105VEQ Cold shock protein S100141_00439 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) S100141_00440 ENOG4108UMI ABC transporter, permease S100141_00442 ENOG4107R6U sodium dicarboxylate symporter S100141_00448 ENOG4105BZU Histidine kinase S100141_00451 ENOG4108YBP pseudouridine synthase S100141_00453 ENOG41080XP Cbs domain S100141_00454 ENOG4107YBY Hydrolase S100141_00455 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase S100141_00457 ENOG4105C5H ABC transporter S100141_00458 ENOG4105TMB Formate nitrite transporter S100141_00459 ENOG4105RK9 auxin efflux carrier S100141_00460 ENOG4105CB2 alcohol dehydrogenase S100141_00461 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator S100141_00463 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) S100141_00465 ENOG4105C6V Glycerol-3-phosphate dehydrogenase S100141_00469 ENOG4105BZU Histidine kinase S100141_00470 ENOG4105WH1 Two component transcriptional regulator luxr family S100141_00474 ENOG4105KPV Transcriptional regulator S100141_00475 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) S100141_00476 ENOG4105ED1 spovr family S100141_00479 ENOG4105BZN citrate synthase S100141_00481 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S100141_00482 ENOG4105C8J )-transporter S100141_00484 ENOG41086D8 Transcriptional regulator S100141_00485 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S100141_00488 ENOG4105J37 S100141_00489 ENOG4108AEY RNA polymerase sigma factor S100141_00490 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein S100141_00492 ENOG4105F6E Acyl-transferase S100141_00494 ENOG4105KAF membrAne S100141_00496 ENOG4105U5Y Transcriptional regulator S100141_00497 ENOG4105C37 (CBS) domain S100141_00500 ENOG4105C37 (CBS) domain S100141_00506 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S100141_00508 ENOG4105D64 Mechanosensitive ion channel S100141_00509 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) S100141_00512 ENOG4107VMI polysaccharide deacetylase S100141_00513 ENOG4105F0I Aminotransferase S100141_00515 ENOG4108N2V aldose 1-epimerase S100141_00520 ENOG4105BZ1 (ABC) transporter S100141_00521 ENOG4105BZ1 (ABC) transporter S100141_00529 ENOG410839P S100141_00531 ENOG4106MP8 UPF0754 membrane protein S100141_00532 ENOG4105WZB UPF0342 protein S100141_00534 ENOG4105D4P Coproporphyrinogen iii oxidase S100141_00535 ENOG4107S91 Sodium hydrogen exchanger S100141_00536 ENOG4105NCW Trka-c domain protein S100141_00538 ENOG4105CGU Enoyl-CoA hydratase S100141_00543 ENOG4108IUX (ABC) transporter S100141_00544 ENOG4105RHA ABC transporter, permease S100141_00545 ENOG4107VRP DNA repair exonuclease S100141_00546 ENOG4106D4I domain protein S100141_00547 ENOG4105EQI Metal Dependent Phosphohydrolase S100141_00549 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) S100141_00556 ENOG4105NBU tryptophan transport protein S100141_00557 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) S100141_00558 ENOG4105K59 histidine triad (HIT) protein S100141_00564 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation S100141_00565 ENOG4105BZ4 penicillin-binding protein S100141_00566 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) S100141_00567 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) S100141_00568 ENOG4105C1Q protoporphyrinogen oxidase S100141_00570 ENOG4105ECB domain protein S100141_00572 ENOG4105DER m42 family S100141_00575 ENOG4106AXD S100141_00576 ENOG4108RQ5 Beta-lactamase domain-containing protein S100141_00577 ENOG4105DF9 Lipoate-protein, ligase S100141_00578 ENOG4105CEY Amp-dependent synthetase and ligase S100141_00580 ENOG4108JCI Transcriptional regulator S100141_00583 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 S100141_00584 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S100141_00585 ENOG4108UZ3 Transporter S100141_00586 ENOG4108HUF Transporter S100141_00587 ENOG4105DQ5 transport system permease protein S100141_00588 ENOG4108U1V ABC transporter, permease S100141_00589 ENOG4107TB6 phosphoglycerate mutase S100141_00590 ENOG4106YBV Methyl-accepting chemotaxis S100141_00594 ENOG4105XVF Competence transcription factor S100141_00595 ENOG41060YP S100141_00598 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin S100141_00600 ENOG4105G9B Transcriptional regulator S100141_00602 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) S100141_00603 ENOG4105CE7 Amidase, hydantoinase carbamoylase family S100141_00604 ENOG4105S0E allantoin catabolism protein S100141_00605 ENOG4105DG4 malate L-lactate dehydrogenase S100141_00606 ENOG4105DG4 malate L-lactate dehydrogenase S100141_00607 ENOG4105DG4 malate L-lactate dehydrogenase S100141_00608 ENOG4107R1Q Membrane protein FdrA S100141_00609 ENOG4107REC cytoplasmic protein S100141_00611 ENOG4105C5B carbamate kinase S100141_00612 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) S100141_00613 ENOG4107CUJ Protein of unknown function (DUF2690) S100141_00614 ENOG410780I phosphoprotein phosphatase activity S100141_00620 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component S100141_00621 ENOG4105I1K ABC transporter S100141_00623 ENOG4108KK1 membrane protein AbrB duplication S100141_00626 ENOG4105WEF catalase S100141_00627 ENOG4105CEY Amp-dependent synthetase and ligase S100141_00628 ENOG4106K7D Major facilitator family transporter S100141_00630 ENOG4105BZU Histidine kinase S100141_00631 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S100141_00633 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein S100141_00634 ENOG4105E0C molybdate abc transporter S100141_00636 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation S100141_00638 ENOG4105EYH Exonuclease S100141_00645 ENOG410751J S100141_00649 ENOG4105ERH Fumarylacetoacetate hydrolase S100141_00654 ENOG4105CAQ asparagine synthetase S100141_00657 ENOG4108YZA Nitrogen regulatory protein pii S100141_00658 ENOG4105UQX Mate efflux family protein S100141_00659 ENOG4106HBX Transcriptional Regulator AraC Family S100141_00661 ENOG4105ETE Transcriptional regulator (LacI family S100141_00662 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S100141_00663 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S100141_00664 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S100141_00666 ENOG4105DY8 decarboxylase S100141_00671 ENOG4105MA6 gCN5-related N-acetyltransferase S100141_00672 ENOG4105H9W Short-chain dehydrogenase reductase Sdr S100141_00673 ENOG4105D29 Helix-turn-helix type 11 domain protein S100141_00676 ENOG4108VPT UPF0234 protein S100141_00677 ENOG4105QNR S1 RNA binding domain protein S100141_00680 ENOG4105EPR degv family S100141_00681 ENOG4107AYK membrAne S100141_00683 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) S100141_00684 ENOG41073B9 S100141_00685 ENOG4108KP7 hydrolase S100141_00686 ENOG4108MXZ Esterase S100141_00687 ENOG4105VG1 fes assembly suf system protein S100141_00688 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase S100141_00689 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) S100141_00690 ENOG4105CAS nag kinase S100141_00691 ENOG4105C8Y Acetylornithine aminotransferase S100141_00692 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain S100141_00694 ENOG4105DBV ornithine carbamoyltransferase S100141_00695 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) S100141_00700 ENOG4107RMD Basic membrane lipoprotein S100141_00703 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) S100141_00704 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) S100141_00706 ENOG4105C3U ABC transporter S100141_00707 ENOG4108JQ7 (ABC) transporter S100141_00710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S100141_00715 ENOG4105C31 Tryptophanyl-tRNA synthetase S100141_00716 ENOG4108J59 Extracellular solute-binding protein, family 5 S100141_00717 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S100141_00718 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S100141_00720 ENOG4108JQ7 (ABC) transporter S100141_00722 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) S100141_00723 ENOG4108ZCF integral membrane protein S100141_00724 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis S100141_00728 ENOG4108V9W transcriptional regulatory protein S100141_00730 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism S100141_00732 ENOG4105DPN Oligoendopeptidase f S100141_00734 ENOG4105T58 Dithiol-disulfide isomerase S100141_00735 ENOG4108Z18 K06886 hemoglobin S100141_00736 ENOG4105E4C Lytic transglycosylase catalytic S100141_00737 ENOG4105MIX Adenylate cyclase S100141_00738 ENOG4106EFP UPF0738 protein S100141_00740 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) S100141_00741 ENOG4105EMS pseudouridine synthase S100141_00742 ENOG4107S1Q Phosphatase S100141_00744 ENOG4105ETU transcriptional activator (TenA S100141_00745 ENOG4108VEU Thiamine monophosphate synthase S100141_00748 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) S100141_00749 ENOG4105D06 uba thif-type nad fad binding protein S100141_00750 ENOG4105DWF phosphomethylpyrimidine kinase S100141_00751 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH S100141_00752 ENOG4107A88 S100141_00762 ENOG4105ENA helicase S100141_00764 ENOG4107T5V SNARE associated Golgi S100141_00765 ENOG4105CMR udp-glucose 4-epimerase S100141_00766 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase S100141_00769 ENOG4108ZMI UPF0477 protein S100141_00773 ENOG4105C28 cystathionine S100141_00774 ENOG4105C28 cystathionine S100141_00775 ENOG4105JHY Membrane S100141_00778 ENOG4105FQP Beta-lactamase S100141_00779 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase S100141_00780 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase S100141_00783 ENOG4108UW5 maltose o-acetyltransferase S100141_00785 ENOG4105DUM transcriptional regulator, lysR family S100141_00786 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S100141_00787 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) S100141_00789 ENOG4108Q5Y Membrane S100141_00790 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase S100141_00792 ENOG41069ER domain protein S100141_00793 ENOG4105C0R drug resistance transporter emrb qaca subfamily S100141_00794 ENOG4105J7D transcriptional regulator S100141_00799 ENOG4107EV6 Inherit from COG: YD repeat protein S100141_00800 ENOG4105K7W phage-related replication protein S100141_00801 ENOG410635T phage-like element pbsx protein S100141_00811 ENOG4108TFU terminase (Small subunit) S100141_00812 ENOG4105IG6 Phage terminase, large subunit S100141_00813 ENOG4108MDF Phage Portal Protein S100141_00818 ENOG41060SN S100141_00821 ENOG4105PQS phage protein S100141_00822 ENOG4105FR7 XkdM protein, phage-like element PBSX S100141_00823 ENOG4105MTC XkdN-like protein S100141_00824 ENOG4108FKH Transglycosylase SLT domain S100141_00825 ENOG4108WZM domain protein S100141_00826 ENOG4105X7F S100141_00828 ENOG4105MFU Protein of unknown function (DUF2634) S100141_00829 ENOG41066EA baseplate J family protein S100141_00830 ENOG410906S phage-like element pbsx protein xkdt S100141_00832 ENOG41068G1 S100141_00833 ENOG41068G1 S100141_00836 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase S100141_00837 ENOG4107XBN GntR Family Transcriptional Regulator S100141_00838 ENOG4105CPQ Dehydrogenase S100141_00839 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) S100141_00840 ENOG4105DMW Dehydrogenase reductase S100141_00841 ENOG4105CPQ Dehydrogenase S100141_00842 ENOG4108I5G Major Facilitator superfamily S100141_00845 ENOG4105CJ3 phosphate transporter S100141_00846 ENOG4107GRR phosphate transport regulator S100141_00847 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) S100141_00850 ENOG4105C2F Histidine kinase S100141_00851 ENOG4105EQD regulatoR S100141_00852 ENOG4105EQD regulatoR S100141_00853 ENOG410769Z extracellular solute-binding protein family 1 S100141_00854 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component S100141_00855 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component S100141_00856 ENOG4105F5H Glycosyl Hydrolase Family 88 S100141_00857 ENOG41075H3 AraC family transcriptional regulator S100141_00858 ENOG4107TDE lipolytic protein G-D-S-L family S100141_00861 ENOG4105CX8 fg-gap repeat protein S100141_00864 ENOG4107TDE lipolytic protein G-D-S-L family S100141_00865 ENOG4105CX8 fg-gap repeat protein S100141_00866 ENOG4105CPC Aldo Keto reductase S100141_00867 ENOG4107TDE lipolytic protein G-D-S-L family S100141_00869 ENOG4105EKC S100141_00870 ENOG4105E0S extracellular solute-binding protein family 1 S100141_00872 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component S100141_00873 ENOG4107R7I amino acid S100141_00876 ENOG4105C0H protease S100141_00878 ENOG4108ME1 Peptidase M55 D-aminopeptidase S100141_00879 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S100141_00880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S100141_00881 ENOG4105C3U ABC transporter S100141_00883 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A S100141_00884 ENOG4105DTQ mandelate racemase muconate lactonizing S100141_00885 ENOG4107SN7 NLP P60 protein S100141_00886 ENOG4108JQ7 (ABC) transporter S100141_00887 ENOG4107TUM Amidinotransferase S100141_00888 ENOG4108S4H thioesterase Superfamily protein S100141_00890 ENOG4108J20 pectate lyase S100141_00896 ENOG410839T multidrug resistance protein S100141_00897 ENOG41080TC multidrug resistance protein S100141_00898 ENOG4105CIY formyltetrahydrofolate deformylase S100141_00899 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) S100141_00900 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) S100141_00902 ENOG4105K56 Transcriptional regulator S100141_00903 ENOG4108ZHJ Organic hydroperoxide resistance protein S100141_00905 ENOG4107Y2X deaminase S100141_00906 ENOG4105CVJ phosphoglycerate mutase S100141_00909 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) S100141_00910 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S100141_00912 ENOG4105CJW magnesium transporter S100141_00914 ENOG4105V75 Transcriptional regulator S100141_00919 ENOG4105DQE DNA ligase S100141_00920 ENOG4105FDF Could be involved in DNA repair (By similarity) S100141_00921 ENOG4105BZU Histidine kinase S100141_00922 ENOG4107T5V SNARE associated Golgi S100141_00923 ENOG4107TS3 membrane protein, TerC S100141_00924 ENOG4108WZW RNA polymerase sigma S100141_00926 ENOG410681C small acid-soluble spore protein S100141_00928 ENOG4105D0M Protease HtpX homolog S100141_00930 ENOG4107RVG penicillin-binding protein S100141_00933 ENOG4108TGC Acyltransferase S100141_00934 ENOG4105BZU Histidine kinase S100141_00935 ENOG4105BZU Histidine kinase S100141_00936 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) S100141_00938 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) S100141_00940 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase S100141_00942 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate S100141_00944 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) S100141_00945 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) S100141_00948 ENOG4105BZU Histidine kinase S100141_00949 ENOG41090MY MarR family Transcriptional regulator S100141_00950 ENOG4105ER2 Ompa motb domain protein S100141_00951 ENOG4105E14 MotA TolQ exbB proton channel S100141_00953 ENOG4108K88 Membrane S100141_00954 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) S100141_00955 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase S100141_00956 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) S100141_00957 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) S100141_00962 ENOG4105NX3 Membrane S100141_00963 ENOG4105VMP Transcriptional regulator S100141_00968 ENOG4105DQ6 Transposase S100141_00974 ENOG4105F0V Cell wall hydrolase S100141_00977 ENOG4105C59 p-type ATPase S100141_00978 ENOG4105DC7 peptidase M24 S100141_00982 ENOG4105CID antiterminator S100141_00984 ENOG4105KRI phosphocarrier protein (HPr S100141_00985 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) S100141_00987 ENOG4105F6S Spore photoproduct lyase S100141_00989 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer S100141_00990 ENOG4105CHR reductase S100141_00991 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase S100141_00992 ENOG4105K4I Scp-like extracellular S100141_00994 ENOG4105BZU Histidine kinase S100141_00995 ENOG4105CHM Aminotransferase S100141_00999 ENOG4107R88 Chemotaxis protein (CheV) S100141_01000 ENOG4105UIN S100141_01002 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein S100141_01004 ENOG4105K6S Short-chain dehydrogenase reductase Sdr S100141_01005 ENOG4105EPM Diguanylate phosphodiesterase S100141_01007 ENOG4107IN1 Protein of unknown function (DUF1797) S100141_01009 ENOG4108XRC Protein of unknown function (DUF458) S100141_01015 ENOG4105NQC Flavodoxin S100141_01016 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) S100141_01019 ENOG4105D3R alkyl hydroperoxide reductase S100141_01020 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S100141_01023 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) S100141_01024 ENOG4105D06 uba thif-type nad fad binding protein S100141_01025 ENOG4105CVM Molybdenum cofactor synthesis domain protein S100141_01026 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein S100141_01027 ENOG4108ZAF Molybdopterin S100141_01028 ENOG41067WU Molybdopterin converting factor (Subunit 1) S100141_01030 ENOG4105BZ1 (ABC) transporter S100141_01031 ENOG4105BZ1 (ABC) transporter S100141_01033 ENOG4107X8C Efflux transporter RND family MFP subunit S100141_01034 ENOG4105C19 ABC transporter S100141_01035 ENOG4107RBB ABC transporter, permease S100141_01036 ENOG4105E98 transcriptional regulator DeoR family S100141_01037 ENOG4105DE4 1-phosphofructokinase S100141_01038 ENOG4105DM4 PTS System S100141_01039 ENOG4105C3F Signal peptidase i S100141_01042 ENOG4105C5H ABC transporter S100141_01048 ENOG4105BZU Histidine kinase S100141_01049 ENOG4107ZYR domain protein S100141_01051 ENOG4105CN5 Metallo-Beta-Lactamase S100141_01053 ENOG4108X4Q Hydrolase S100141_01055 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) S100141_01059 ENOG4105CPP Dehydrogenase, E1 component S100141_01060 ENOG4105C7S Dehydrogenase S100141_01061 ENOG4107QN2 dihydrolipoyl dehydrogenase S100141_01065 ENOG4105CXN decarboxylase S100141_01066 ENOG4105WBI UPF0223 protein S100141_01069 ENOG4105ECY inositol monophosphatase S100141_01076 ENOG4105CI3 gtp-binding protein typa S100141_01077 ENOG4105QA2 S100141_01078 ENOG4108INS Transcriptional regulator S100141_01079 ENOG4107SCK Monooxygenase S100141_01082 ENOG4108IAB Phoh family S100141_01084 ENOG4105CSV Glutaminase S100141_01085 ENOG4105ZPI UPF0358 protein S100141_01086 ENOG4105CNI cell division protein FtsW S100141_01087 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) S100141_01089 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) S100141_01091 ENOG4105BZ9 Cytochrome C oxidase, subunit I S100141_01092 ENOG4105CCU oxidase (Subunit III) S100141_01093 ENOG41064X9 cytochrome C oxidase subunit IV S100141_01096 ENOG41080XQ Signal transduction protein with cbs domains S100141_01097 ENOG4106UY4 Inherit from COG: Scp-like extracellular S100141_01104 ENOG4106H78 methyltransferase S100141_01105 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) S100141_01106 ENOG4105H20 Sporulation integral membrane protein YlbJ S100141_01107 ENOG41063PX domain protein S100141_01108 ENOG4105CDE UPF0348 protein S100141_01109 ENOG4105KNH Nucleic acid-binding protein S100141_01110 ENOG41067VY 50S ribosomal protein L32 S100141_01114 ENOG41074B2 UPF0747 protein S100141_01115 ENOG4108V6E Cell division protein mraZ S100141_01116 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) S100141_01118 ENOG4105CJN penicillin-binding protein S100141_01119 ENOG4105CJN penicillin-binding protein S100141_01121 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) S100141_01122 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) S100141_01123 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) S100141_01124 ENOG4105CNI cell division protein FtsW S100141_01125 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) S100141_01126 ENOG4105D4A Cell wall formation (By similarity) S100141_01127 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) S100141_01128 ENOG4108R2U division initiation protein S100141_01130 ENOG4105K67 small basic protein S100141_01131 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) S100141_01132 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) S100141_01137 ENOG4105FFI sigma-e processing peptidase spoiiga S100141_01138 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_01140 ENOG4105DKW ABC transporter S100141_01141 ENOG4105DHI Methyltransferase S100141_01142 ENOG4105WR5 sporulation protein, YlmC YmxH family S100141_01143 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase S100141_01144 ENOG4105DFA alanine racemase domain protein S100141_01145 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) S100141_01146 ENOG41067XK integral membrane protein S100141_01147 ENOG4105DBK s4 domain protein S100141_01151 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) S100141_01152 ENOG4105C34 Pseudouridine synthase S100141_01153 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) S100141_01155 ENOG4105CXT aspartate transcarbamylase S100141_01156 ENOG4105CD3 dihydroorotase S100141_01157 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain S100141_01158 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain S100141_01159 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) S100141_01160 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) S100141_01161 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) S100141_01164 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) S100141_01168 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) S100141_01169 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein S100141_01170 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein S100141_01171 ENOG4105F23 Fibronectin-binding protein S100141_01173 ENOG4105DSJ YicC domain protein S100141_01174 ENOG4105KC4 UPF0296 protein S100141_01175 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) S100141_01176 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) S100141_01177 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase S100141_01178 ENOG4105C25 Primosomal protein n' S100141_01179 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) S100141_01180 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) S100141_01181 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B S100141_01182 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs S100141_01183 ENOG4108ZF3 Phosphatase S100141_01184 ENOG4105D9P serine threonine protein kinase S100141_01185 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) S100141_01186 ENOG4105DJV ribulose-phosphate 3-epimerase S100141_01187 ENOG4105FJ0 thiamine S100141_01188 ENOG4105VB9 50S ribosomal protein l28 S100141_01189 ENOG4108ZAA Alkaline-shock protein S100141_01190 ENOG4105DP4 dak2 domain fusion protein ylov S100141_01192 ENOG4105EJQ L-serine dehydratase S100141_01193 ENOG4105CB5 ATP-dependent DNA helicase recG S100141_01194 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) S100141_01195 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) S100141_01196 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase S100141_01197 ENOG4105CHR reductase S100141_01198 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) S100141_01199 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) S100141_01200 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) S100141_01201 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) S100141_01202 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) S100141_01204 ENOG4105K5M 30s ribosomal protein S16 S100141_01205 ENOG4108BW8 UPF0109 protein S100141_01207 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) S100141_01208 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) S100141_01209 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) S100141_01210 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) S100141_01211 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) S100141_01213 ENOG4105VM1 flagellar S100141_01214 ENOG4105CMV Succinyl-CoA synthetase subunit beta S100141_01215 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha S100141_01216 ENOG4105C79 DNA protecting protein DprA S100141_01217 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) S100141_01218 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) S100141_01219 ENOG4108HE4 integrase family S100141_01220 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) S100141_01221 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) S100141_01222 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) S100141_01224 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) S100141_01225 ENOG4108ZC9 flagellar basal-body rod protein flgc S100141_01226 ENOG4105VQ0 flagellar hook-basal body complex protein fliE S100141_01227 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) S100141_01228 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) S100141_01231 ENOG4106YF4 Flagellar biosynthesis chaperone S100141_01233 ENOG410696Y Flagellar hook-length control protein S100141_01234 ENOG410822I Flagellar hook capping protein S100141_01235 ENOG4108JQA flagellar S100141_01237 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) S100141_01238 ENOG4105DD5 Flagellar motor switch protein S100141_01239 ENOG4107YTP response regulator receiver protein S100141_01241 ENOG4105CN7 Flagellar biosynthetic protein FliP S100141_01242 ENOG4105VS8 Flagellar biosynthetic protein fliq S100141_01243 ENOG4105D19 Role in flagellar biosynthesis (By similarity) S100141_01244 ENOG4105D00 flagellar biosynthetic protein flhB S100141_01245 ENOG4105D7B Flagellar biosynthesis protein flha S100141_01246 ENOG4105FZW flagellar biosynthesis regulator FlhF S100141_01248 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) S100141_01249 ENOG4105CBS Chea signal transduction histidine kinase S100141_01250 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis S100141_01252 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) S100141_01253 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_01255 ENOG4105CE9 30S ribosomal protein S2 S100141_01256 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) S100141_01258 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) S100141_01259 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) S100141_01260 ENOG4105KNE Phosphatidate cytidylyltransferase S100141_01262 ENOG4105DZP Membrane-associated zinc metalloprotease S100141_01264 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) S100141_01267 ENOG4105CYP glycoside hydrolase, family S100141_01270 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) S100141_01271 ENOG4105CHV Transcription elongation factor NusA S100141_01272 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination S100141_01273 ENOG4105VHM ribosomal protein S100141_01274 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) S100141_01275 ENOG4105W7A Protein of unknown function (DUF503) S100141_01276 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) S100141_01277 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) S100141_01278 ENOG4105DTN riboflavin biosynthesis protein ribF S100141_01279 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) S100141_01280 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) S100141_01282 ENOG4105C1V Peptidase, M16 S100141_01284 ENOG4105E35 Dipicolinate synthase subunit A S100141_01285 ENOG4108S0H Dipicolinic acid synthetase, b subunit S100141_01286 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) S100141_01288 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) S100141_01290 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit S100141_01292 ENOG4105CNU cell division protein FtsK S100141_01293 ENOG4105FDP GntR family transcriptional regulator S100141_01297 ENOG4108RKS Short-chain dehydrogenase reductase Sdr S100141_01298 ENOG4105XZV Protein of unknown function (DUF3243) S100141_01301 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase S100141_01302 ENOG4105CEV competence damage-inducible protein S100141_01303 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) S100141_01305 ENOG4105D48 metallophosphoesterase S100141_01306 ENOG4105MCT stage V sporulation protein S S100141_01307 ENOG4108IGT Dipeptidase S100141_01308 ENOG4105CPQ Dehydrogenase S100141_01309 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) S100141_01310 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) S100141_01313 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) S100141_01314 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) S100141_01316 ENOG4107EV6 Inherit from COG: YD repeat protein S100141_01319 ENOG4105CKI cobalamin synthesis protein S100141_01321 ENOG4107TCE N-acetyltransferase S100141_01325 ENOG4105XPP Protein of unknown function (DUF1275) S100141_01326 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) S100141_01327 ENOG4108J8C transporter major facilitator family protein S100141_01328 ENOG4108J8C transporter major facilitator family protein S100141_01329 ENOG4105U6C Alpha beta hydrolase fold protein S100141_01331 ENOG41080BT SNARE associated Golgi S100141_01332 ENOG4105FQP Beta-lactamase S100141_01333 ENOG41087PP glycosyltransferase MGT family S100141_01334 ENOG4107QTZ amino acid S100141_01337 ENOG4105VRS hydrolase family 18 S100141_01338 ENOG4105M4P Tetr family transcriptional regulator S100141_01339 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein S100141_01340 ENOG4107S9F NmrA family S100141_01342 ENOG4108X3M OsmC Ohr family protein S100141_01343 ENOG4107E54 Small Multidrug Resistance protein S100141_01347 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) S100141_01348 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) S100141_01350 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) S100141_01351 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S100141_01352 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S100141_01353 ENOG4105U6W MutT NUDIX family protein S100141_01356 ENOG4108UNV SUF system FeS assembly protein, NifU family S100141_01357 ENOG4105G5W regulator Fur family S100141_01358 ENOG4105DRR Transcriptional regulator, GntR family S100141_01365 ENOG4105PF9 Transcriptional regulator S100141_01374 ENOG4107EV6 Inherit from COG: YD repeat protein S100141_01378 ENOG4106F1P AAA ATPase, central domain protein S100141_01379 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) S100141_01380 ENOG4105CXI aluminum resistance protein S100141_01381 ENOG4105KV4 Transcriptional regulator S100141_01382 ENOG4105C5F glutamine synthetase S100141_01388 ENOG4105K59 histidine triad (HIT) protein S100141_01404 ENOG4108MK9 spermidine N(1)-acetyltransferase S100141_01407 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S100141_01412 ENOG41062JF Transcriptional regulator S100141_01413 ENOG41090MY MarR family Transcriptional regulator S100141_01414 ENOG4108TVJ Nitroreductase S100141_01415 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase S100141_01416 ENOG4107XWI flavin reductase domain protein, FMN-binding S100141_01417 ENOG4105CS1 NAD(P)H quinone oxidoreductase S100141_01420 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) S100141_01421 ENOG4105WFK nuclease S100141_01423 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) S100141_01425 ENOG4108SVB resolvase S100141_01426 ENOG4105VPS UPF0291 protein S100141_01427 ENOG4105CV1 Transketolase (EC 2.2.1.1) S100141_01429 ENOG4105VXM UPF0154 protein S100141_01431 ENOG4107QIV Cytochrome c biogenesis protein S100141_01436 ENOG4108I0Z Aconitate hydratase S100141_01437 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S100141_01442 ENOG4105MI2 S100141_01445 ENOG4105W8X HesB YadR YfhF-family protein S100141_01446 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) S100141_01447 ENOG4105K4P CoA-binding domain protein S100141_01448 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S100141_01450 ENOG4105CMD Transcriptional regulator, GntR family S100141_01453 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) S100141_01454 ENOG4107QNK )-transporter S100141_01455 ENOG4105CHR reductase S100141_01461 ENOG4105R3A Nitrate reductase S100141_01462 ENOG4108IUE nitrate reductase beta subunit S100141_01469 ENOG4107V6Q Cyclic nucleotide-binding domain S100141_01472 ENOG4105IJJ transcriptional regulator, crp fnr family S100141_01473 ENOG4105DSQ Nitric oxide reductase S100141_01474 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) S100141_01475 ENOG4106U2H Protein of unknown function (DUF1360) S100141_01476 ENOG4107QWR cellulase (EC 3.2.1.4) S100141_01478 ENOG4108428 Inherit from COG: -acetyltransferase S100141_01480 ENOG4105C3M thioredoxin reductase S100141_01483 ENOG4108M26 parallel beta-helix repeat protein S100141_01485 ENOG4105DQ4 alcohol dehydrogenase S100141_01486 ENOG4105VUF Transcriptional regulator S100141_01491 ENOG41060WC Enoyl-CoA hydratase S100141_01492 ENOG4105C26 Dehydrogenase S100141_01493 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase S100141_01494 ENOG4105C1G acyl-Coa dehydrogenase S100141_01495 ENOG4105DG6 mannose-6-phosphate isomerase S100141_01496 ENOG4105DM4 PTS System S100141_01503 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family S100141_01504 ENOG4105DMW Dehydrogenase reductase S100141_01505 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) S100141_01507 ENOG4105CG6 trap dicarboxylate transporter dctm subunit S100141_01508 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter S100141_01509 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit S100141_01510 ENOG4107KJX Transcriptional regulator S100141_01511 ENOG4108UXE Protein tyrosine phosphatase S100141_01512 ENOG4107R5R arsenical pump membrane protein S100141_01513 ENOG41082YX Transcriptional regulator, arsr family S100141_01514 ENOG4105CZ9 Domain of unknown function (DU1801) S100141_01516 ENOG4105CSC Glucose uptake protein S100141_01517 ENOG4105F32 YngK protein S100141_01520 ENOG4105F1A Pyruvate formate-lyase S100141_01522 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family S100141_01523 ENOG4105H67 Protein of unknown function (DUF421) S100141_01524 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S100141_01526 ENOG4108QY0 Membrane S100141_01529 ENOG4105CZ3 stage V sporulation protein ad S100141_01530 ENOG41090VF Stage v sporulation protein ac S100141_01532 ENOG4105DQ6 Transposase S100141_01533 ENOG4105WEF catalase S100141_01537 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S100141_01547 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) S100141_01548 ENOG4107QX3 carboxylase S100141_01549 ENOG4105E39 Enoyl-CoA hydratase S100141_01550 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase S100141_01551 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit S100141_01552 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase S100141_01553 ENOG4105CEY Amp-dependent synthetase and ligase S100141_01554 ENOG4105C1G acyl-Coa dehydrogenase S100141_01555 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein S100141_01556 ENOG4105KVH Transcriptional regulator S100141_01557 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) S100141_01558 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) S100141_01561 ENOG4105H67 Protein of unknown function (DUF421) S100141_01562 ENOG4105H67 Protein of unknown function (DUF421) S100141_01564 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) S100141_01565 ENOG41061P3 phosphosulfolactate synthase S100141_01567 ENOG4105DIA mandelate racemase muconate lactonizing S100141_01568 ENOG4107RCC Major Facilitator Superfamily S100141_01572 ENOG4105BZ8 glutamate synthase S100141_01573 ENOG4105CBC glutamate synthase S100141_01574 ENOG4105C5Q Transcriptional regulator S100141_01580 ENOG4105BZ1 (ABC) transporter S100141_01583 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) S100141_01584 ENOG4105C0R drug resistance transporter emrb qaca subfamily S100141_01585 ENOG4108J2R molybdopterin oxidoreductase S100141_01588 ENOG4108Q8B Spore germination protein S100141_01590 ENOG4108NHD germination protein S100141_01591 ENOG4108Q8B Spore germination protein S100141_01592 ENOG4108Q8B Spore germination protein S100141_01593 ENOG4108Q8B Spore germination protein S100141_01596 ENOG4105C8Q Methyl-accepting chemotaxis S100141_01597 ENOG4108Z7R Chaperone CsaA S100141_01598 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S100141_01600 ENOG4108RZE Tetr family transcriptional regulator S100141_01602 ENOG4105T9C HD domain S100141_01604 ENOG4105FVX S100141_01608 ENOG4108W8B Beta-lactamase domain protein S100141_01611 ENOG4105D29 Helix-turn-helix type 11 domain protein S100141_01613 ENOG4105KTU Transcriptional regulator, arsr family S100141_01616 ENOG4105CUB amino acid S100141_01618 ENOG4105C5E polysaccharide biosynthesis protein S100141_01621 ENOG4107T8Q Glycosyl transferase (Group 1 S100141_01622 ENOG4108SJC Membrane S100141_01625 ENOG4107RUZ Sss sodium solute transporter superfamily S100141_01626 ENOG41069ER domain protein S100141_01627 ENOG4105C9U ATP-dependent DNA helicase RecQ S100141_01632 ENOG4105UNS Pfam:DUF419 S100141_01635 ENOG4108IEG Formate dehydrogenase Alpha subunit S100141_01637 ENOG4107EV6 Inherit from COG: YD repeat protein S100141_01646 ENOG4108NHD germination protein S100141_01649 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) S100141_01652 ENOG4107S9D Alpha beta hydrolase S100141_01656 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) S100141_01658 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) S100141_01659 ENOG4105ST3 Transcriptional regulator S100141_01663 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) S100141_01664 ENOG4105SCY DNAK suppressor S100141_01667 ENOG4105C26 Dehydrogenase S100141_01671 ENOG4105EWU Squalene--hopene cyclase S100141_01672 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) S100141_01674 ENOG4105C8J )-transporter S100141_01675 ENOG4105C09 Bile acid S100141_01676 ENOG4105C7S Dehydrogenase S100141_01677 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 S100141_01678 ENOG4107T89 von Willebrand factor, type A S100141_01679 ENOG4105GMT ATPase associated with various cellular activities aaa_5 S100141_01681 ENOG4105K4H Nlp p60 protein S100141_01686 ENOG4105FR1 rard protein S100141_01689 ENOG4108YQE rare lipoprotein a S100141_01691 ENOG4107EXU Short-chain dehydrogenase reductase Sdr S100141_01694 ENOG4105FBA Phospholipase Carboxylesterase S100141_01696 ENOG4105E1V na solute symporter S100141_01697 ENOG4105DQ6 Transposase S100141_01702 ENOG4108VXD carboxy-peptidase S100141_01703 ENOG4105D3A purine nucleoside phosphorylase DeoD-type S100141_01704 ENOG4108PJD permease S100141_01707 ENOG4106Z5R S100141_01708 ENOG410841Q phosphoesterase PA-phosphatase related protein S100141_01712 ENOG4105VSD UPF0346 protein S100141_01714 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein S100141_01715 ENOG4108TSC N-acetyltransferase S100141_01716 ENOG4107S4Y M20 DapE family protein YgeY S100141_01719 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S100141_01722 ENOG4105E0X reductase S100141_01726 ENOG4105BZU Histidine kinase S100141_01730 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) S100141_01731 ENOG41090WU lipolytic protein G-D-S-L family S100141_01732 ENOG4108KF3 Electron transport protein SCO1 SenC S100141_01735 ENOG4105C7B Threonine dehydratase S100141_01737 ENOG4108UT2 hemolysin iii S100141_01739 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) S100141_01742 ENOG4107YX5 Pfam:DUF548 S100141_01744 ENOG4105C01 Dihydroxy-acid dehydratase S100141_01747 ENOG4108V06 Glutathione peroxidase S100141_01748 ENOG4105CKU formyltetrahydrofolate synthetase S100141_01749 ENOG4105CVG Homoserine O-transsuccinylase S100141_01750 ENOG4108QBV Monogalactosyldiacylglycerol synthase S100141_01758 ENOG41081VK Ribonuclease S100141_01763 ENOG410890F Dynamin family S100141_01765 ENOG41065KQ synthase S100141_01766 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) S100141_01767 ENOG4105C2W permease S100141_01768 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) S100141_01769 ENOG4105CTD carboxy-peptidase S100141_01770 ENOG4105DVT helicase S100141_01773 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) S100141_01774 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) S100141_01775 ENOG4108UKS UPF0398 protein S100141_01778 ENOG4107X2U Inherit from COG: Exonuclease-like protein S100141_01779 ENOG4108I5C dEAD DEAH box helicase S100141_01789 ENOG4105BZ4 penicillin-binding protein S100141_01791 ENOG4105CSM endonuclease III S100141_01794 ENOG4105CHM Aminotransferase S100141_01796 ENOG4105YAC S100141_01797 ENOG4105DVT helicase S100141_01798 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) S100141_01799 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) S100141_01800 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) S100141_01802 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate S100141_01803 ENOG4105CPK Glycosyl transferase (Group 1 S100141_01804 ENOG4105FJR Lmbe family S100141_01805 ENOG4108Z5K methylglyoxal synthase S100141_01806 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) S100141_01807 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase S100141_01808 ENOG4108JYZ YitT family S100141_01812 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) S100141_01815 ENOG4108SXZ UPF0302 protein S100141_01816 ENOG41068YB TPR repeat-containing protein S100141_01819 ENOG4105CIH Imidazole acetol-phosphate transaminase S100141_01820 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) S100141_01821 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) S100141_01823 ENOG4105DK0 Indole-3-glycerol phosphate synthase S100141_01824 ENOG4108I0Q anthranilate phosphoribosyltransferase S100141_01825 ENOG4105CRQ synthase (Component I) S100141_01826 ENOG4105KHN chorismate mutase S100141_01827 ENOG4105D49 3-dehydroquinate synthase S100141_01828 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase S100141_01829 ENOG4105BZU Histidine kinase S100141_01830 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) S100141_01831 ENOG4105EAH synthase S100141_01832 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) S100141_01833 ENOG4105XXQ heptaprenyl diphosphate synthase component I S100141_01835 ENOG4105EUJ GTP cyclohydrolase i S100141_01836 ENOG4105K70 DNA-binding protein S100141_01837 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) S100141_01840 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase S100141_01841 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) S100141_01842 ENOG41065D1 S100141_01843 ENOG4105S2F S100141_01846 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) S100141_01847 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) S100141_01848 ENOG4105CAT Cytidine monophosphate kinase S100141_01850 ENOG4105MSI germination protein ypeb S100141_01853 ENOG4105HDK L-asparaginase S100141_01854 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase S100141_01857 ENOG4107RGJ metallophosphoesterase S100141_01860 ENOG4105I7S Abortive infection protein S100141_01861 ENOG4105C9U ATP-dependent DNA helicase RecQ S100141_01862 ENOG4105T7X S100141_01864 ENOG4108SAX Membrane S100141_01865 ENOG4108JQ1 Dehydrogenase S100141_01866 ENOG4105DR5 peptidase S100141_01872 ENOG4105US7 Histidine kinase S100141_01873 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S100141_01874 ENOG4105BZU Histidine kinase S100141_01875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S100141_01876 ENOG4105CRE cytochrome C S100141_01877 ENOG4107TWT Cytochrome c biogenesis protein S100141_01878 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S100141_01879 ENOG4105FE9 pseudouridine synthase S100141_01881 ENOG4108JIC nucleoside recognition domain protein S100141_01882 ENOG4105DZ1 carboxypeptidase S100141_01884 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) S100141_01885 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) S100141_01889 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) S100141_01890 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) S100141_01891 ENOG4108R6K riboflavin synthase, subunit alpha S100141_01892 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) S100141_01894 ENOG4105MEW serine threonine protein phosphatase S100141_01895 ENOG4105MYT Heat shock protein S100141_01898 ENOG4107ZE5 PPIases accelerate the folding of proteins S100141_01899 ENOG4105PTM secreted protein S100141_01900 ENOG4105K7W phage-related replication protein S100141_01901 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) S100141_01904 ENOG4105G6R Stage v sporulation protein ae S100141_01906 ENOG4105CZ3 stage V sporulation protein ad S100141_01907 ENOG41090VF Stage v sporulation protein ac S100141_01910 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_01911 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) S100141_01912 ENOG41082AN stage II sporulation protein S100141_01913 ENOG4105DZ1 carboxypeptidase S100141_01914 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) S100141_01915 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) S100141_01916 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S100141_01918 ENOG4105I3K Ferric uptake regulator, Fur family S100141_01919 ENOG4105MZ9 stage II sporulation protein m S100141_01920 ENOG4105CK1 PTS System S100141_01922 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease S100141_01923 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease S100141_01926 ENOG4107YB6 acetyltransferase, (GNAT) family S100141_01928 ENOG4108YZ4 nudix hydrolase S100141_01930 ENOG4105PF9 Transcriptional regulator S100141_01932 ENOG4105CPC Aldo Keto reductase S100141_01936 ENOG4106HZJ S100141_01938 ENOG4105RHY Pfam:UPF0157 S100141_01939 ENOG4105KAC Antibiotic biosynthesis monooxygenase S100141_01940 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold S100141_01942 ENOG4107RRN ABC transporter substrate-binding protein S100141_01943 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S100141_01944 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S100141_01945 ENOG4108RZA ABC transporter S100141_01946 ENOG4107R73 Mate efflux family protein S100141_01950 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S100141_01952 ENOG4105E5W Transporter S100141_01953 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase S100141_01956 ENOG4105DA5 (ABC) transporter S100141_01960 ENOG4105K7W phage-related replication protein S100141_01961 ENOG4108IXY short-chain dehydrogenase reductase S100141_01962 ENOG41069FQ Metallo-beta-lactamase superfamily S100141_01963 ENOG4105II7 pyrroline-5-carboxylate reductase S100141_01965 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S100141_01968 ENOG4105WDJ 50S ribosomal protein L33 S100141_01969 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) S100141_01970 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase S100141_01974 ENOG4108TZY GntR Family Transcriptional Regulator S100141_01975 ENOG4105CS2 ec 3.2.1.21 S100141_01976 ENOG4105CK1 PTS System S100141_01977 ENOG4105VCP PTS System S100141_01978 ENOG4105VZJ PTS System S100141_01979 ENOG4105G6Z alkaline phosphatase S100141_01980 ENOG4105H9W Short-chain dehydrogenase reductase Sdr S100141_01981 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) S100141_01982 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S100141_01984 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) S100141_01985 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) S100141_01986 ENOG4108HNZ carboxyl transferase S100141_01987 ENOG4108QEG Membrane S100141_01988 ENOG4105CDA abc transporter atp-binding protein S100141_01989 ENOG4105E5Q amino acid AbC transporter S100141_01990 ENOG4108HW3 (ABC) transporter S100141_01992 ENOG4108Y6J UPF0403 protein S100141_01993 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) S100141_01994 ENOG4105C7S Dehydrogenase S100141_01995 ENOG4105CPP Dehydrogenase, E1 component S100141_01998 ENOG4105CKM Branched-chain carboxylic acid kinase S100141_01999 ENOG4107RDP Dehydrogenase S100141_02001 ENOG4108JUB Transcriptional regulator S100141_02002 ENOG4106CCJ Protein of unknown function (DUF2627) S100141_02003 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S100141_02004 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S100141_02006 ENOG4105D7W serine acetyltransferase S100141_02008 ENOG4107QQR Sporulation S100141_02009 ENOG4105S1Z Stage IV sporulation protein B S100141_02010 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) S100141_02011 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) S100141_02012 ENOG4105DX0 Hemolysin A S100141_02013 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) S100141_02014 ENOG4105CTB Polyprenyl synthetase S100141_02015 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) S100141_02016 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) S100141_02017 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) S100141_02018 ENOG4105M7K Involved in the transcription termination process (By similarity) S100141_02019 ENOG4108ZSR alkaline shock protein S100141_02020 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase S100141_02024 ENOG410644B Stage III sporulation protein af S100141_02026 ENOG4105KQ4 Stage iii sporulation protein ad S100141_02027 ENOG4108CQH stage III sporulation protein AC S100141_02028 ENOG4105KR5 Stage iii sporulation protein S100141_02029 ENOG4105CD2 stage iii sporulation protein aa S100141_02031 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) S100141_02032 ENOG4105DC7 peptidase M24 S100141_02033 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) S100141_02035 ENOG4105CBJ Metal-dependent enzyme S100141_02038 ENOG4105KST dependent repressor S100141_02039 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) S100141_02040 ENOG4105WZW rhodanese family S100141_02042 ENOG4107SQ8 Glycine betaine S100141_02043 ENOG4108IJ7 Glycine betaine S100141_02044 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor S100141_02046 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) S100141_02047 ENOG4105C0D helicase S100141_02052 ENOG4105VFR signal peptidase S100141_02059 ENOG4106855 Competence protein S100141_02066 ENOG4105C5X domain protein S100141_02073 ENOG4105E0M Sulfatase S100141_02077 ENOG4107ZXI Rhomboid family S100141_02079 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase S100141_02080 ENOG4105WDJ 50S ribosomal protein L33 S100141_02084 ENOG41068DG YceG-like family S100141_02085 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) S100141_02086 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) S100141_02087 ENOG4105E2Z phosphate ABC transporter (Permease S100141_02088 ENOG4105C8U phosphate abc transporter S100141_02089 ENOG4105CVA phosphate S100141_02090 ENOG4107RF6 penicillin-binding protein S100141_02092 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) S100141_02093 ENOG4105SXS Protein of unknown function (DUF456) S100141_02096 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) S100141_02097 ENOG41063Y9 S100141_02098 ENOG4108U5J '-nucleotidase S100141_02099 ENOG4105N80 Ferric uptake regulator, Fur family S100141_02100 ENOG4105FAV ABC, transporter S100141_02101 ENOG4105FDK ABC transporter S100141_02102 ENOG4108JYZ YitT family S100141_02103 ENOG41069ZM Protein of unknown function (DUF2624) S100141_02104 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) S100141_02107 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) S100141_02108 ENOG4105EGD dinuclear metal center protein, YbgI family S100141_02110 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) S100141_02111 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) S100141_02124 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_02125 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) S100141_02127 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) S100141_02129 ENOG4105C38 Glycyl-tRNA synthetase beta subunit S100141_02130 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit S100141_02131 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) S100141_02133 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) S100141_02134 ENOG4105KG3 cytidine deaminase S100141_02135 ENOG4107YR5 Diacylglycerol kinase S100141_02136 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) S100141_02137 ENOG4105CTJ Metal Dependent Phosphohydrolase S100141_02138 ENOG4105C9A Phoh family S100141_02139 ENOG4105EI1 sporulation protein yqfd S100141_02140 ENOG41068P3 sporulation protein YqfC S100141_02142 ENOG4105DI5 UPF0365 protein S100141_02143 ENOG4105F7J membrane-bound serine protease S100141_02144 ENOG4105KTH gatB Yqey S100141_02145 ENOG4105VCC 30S ribosomal protein S21 S100141_02147 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) S100141_02148 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) S100141_02149 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) S100141_02150 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) S100141_02151 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) S100141_02152 ENOG4105CFG Acts as a chaperone (By similarity) S100141_02153 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ S100141_02154 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) S100141_02155 ENOG4105CSA Coproporphyrinogen iii oxidase S100141_02156 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) S100141_02158 ENOG4108ZRV stage ii sporulation protein p S100141_02161 ENOG4105TQK DNA polymerase iii, delta' subunit S100141_02163 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 S100141_02164 ENOG4108UK2 deaminase S100141_02165 ENOG4105KQC Competence protein S100141_02167 ENOG4108D32 Methyltransferase S100141_02169 ENOG4108WF2 Metal Dependent Phosphohydrolase S100141_02170 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) S100141_02171 ENOG410812S Rna-binding protein S100141_02172 ENOG4105E2X shikimate dehydrogenase S100141_02173 ENOG4105CQW ribosome biogenesis GTPase YqeH S100141_02174 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase S100141_02177 ENOG4105Z7P Acetyltransferase (GNAT) family S100141_02178 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) S100141_02179 ENOG4108JB9 formate dehydrogenase S100141_02182 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_02188 ENOG4108ZRV stage ii sporulation protein p S100141_02191 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_02195 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_02197 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) S100141_02198 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) S100141_02200 ENOG4105EFI regulatoR S100141_02203 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_02212 ENOG4105WH1 Two component transcriptional regulator luxr family S100141_02213 ENOG4105BZU Histidine kinase S100141_02214 ENOG4105XXY Thioredoxin S100141_02215 ENOG41087NI Sulfite exporter TauE/SafE S100141_02216 ENOG4105VFE sira family S100141_02217 ENOG4107TPS domain protein S100141_02218 ENOG4105VFE sira family S100141_02219 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase S100141_02220 ENOG4105XTG Pfam:DUF156 S100141_02221 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) S100141_02224 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) S100141_02226 ENOG41080HJ 6-phospho 3-hexuloisomerase S100141_02227 ENOG4108VA3 3-hexulose-6-phosphate synthase S100141_02228 ENOG4105KVH Transcriptional regulator S100141_02229 ENOG4105ECK Fatty Acid Desaturase S100141_02230 ENOG4108ZGX Histidine kinase S100141_02231 ENOG4108S01 response regulator S100141_02232 ENOG4105CAY ferredoxin--nadp reductase S100141_02233 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein S100141_02234 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S100141_02235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S100141_02237 ENOG4108JQ7 (ABC) transporter S100141_02240 ENOG4108ZX5 transcriptional regulator S100141_02241 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S100141_02245 ENOG410635A Membrane S100141_02247 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S100141_02248 ENOG4108HKT sucrose-6-phosphate hydrolase S100141_02249 ENOG4105F3R pts system mannose fructose sorbose family iid S100141_02250 ENOG4105ETZ PTS System S100141_02251 ENOG4108IQ3 PTS system S100141_02252 ENOG4105YHU PTS system S100141_02253 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family S100141_02254 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family S100141_02256 ENOG4105WDR S100141_02258 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) S100141_02259 ENOG4105CV8 reductase S100141_02260 ENOG4105F27 Major Facilitator S100141_02261 ENOG4105KVH Transcriptional regulator S100141_02262 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) S100141_02263 ENOG4105EXQ uroporphyrinogen iii synthase hem4 S100141_02265 ENOG4108V5C ABC transporter S100141_02266 ENOG4107RSM transcriptional regulator S100141_02267 ENOG4105D94 Major Facilitator Superfamily S100141_02269 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S100141_02270 ENOG41082JN Transcriptional regulator S100141_02271 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S100141_02276 ENOG4105C28 cystathionine S100141_02278 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) S100141_02279 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) S100141_02282 ENOG4107XRG penicillin-binding protein S100141_02283 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) S100141_02285 ENOG4105CFP Peptidase U32 S100141_02286 ENOG4105XYU peptidase (U32 family) S100141_02287 ENOG4108VQJ O-methyltransferase S100141_02288 ENOG4105HHA aminodeoxychorismate lyase S100141_02290 ENOG4105VPH UPF0473 protein S100141_02291 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) S100141_02292 ENOG4105VBH UPF0297 protein S100141_02293 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) S100141_02294 ENOG4105C02 permease S100141_02295 ENOG41060CR S100141_02297 ENOG4105C7H Helicase, RecD TraA family S100141_02299 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) S100141_02300 ENOG4105C3J Cysteine desulfurase S100141_02302 ENOG4105D1H recombination factor protein RarA S100141_02303 ENOG4105CUZ uba thif-type nad fad binding protein S100141_02304 ENOG4105C9M aspartyl-trna synthetase S100141_02305 ENOG4105CUT histidyl-tRNA synthetase S100141_02307 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S100141_02308 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) S100141_02309 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) S100141_02310 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) S100141_02311 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) S100141_02312 ENOG41067VP Protein of unknown function (DUF1049) S100141_02313 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) S100141_02315 ENOG4105CKP Polysaccharide Biosynthesis Protein S100141_02316 ENOG4108QG2 Membrane S100141_02317 ENOG4105NAP S100141_02318 ENOG4105VIE preprotein translocase, subunit YajC S100141_02319 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) S100141_02320 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) S100141_02321 ENOG41061AI Protein of unknown function (DUF2905) S100141_02322 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) S100141_02323 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) S100141_02327 ENOG41069DP small acid-soluble spore protein S100141_02329 ENOG4105K7W phage-related replication protein S100141_02332 ENOG4105CDY transcriptional regulatory protein S100141_02334 ENOG4106678 morphogenetic protein associated with SpoVID S100141_02335 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) S100141_02336 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase S100141_02337 ENOG4108IYU L-aspartate oxidase S100141_02340 ENOG4105CQC Prephenate dehydratase S100141_02341 ENOG41090I5 UPF0735 ACT domain-containing protein S100141_02342 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control S100141_02344 ENOG4105K46 50S ribosomal protein l27 S100141_02345 ENOG4105X36 (ribosomal) protein S100141_02346 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) S100141_02350 ENOG41082BM Transcriptional regulator, arsr family S100141_02351 ENOG4107QMS site-determining protein S100141_02352 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) S100141_02353 ENOG4105YHC Rod shape-determining protein MreD S100141_02354 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) S100141_02355 ENOG4105DFF Rod shape-determining protein mreb S100141_02356 ENOG4105W5Q DNA repair protein (RadC S100141_02368 ENOG41068G1 S100141_02370 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj S100141_02383 ENOG4105CAR Terminase, large subunit S100141_02409 ENOG4108C33 Resolvase S100141_02410 ENOG4105W5Q DNA repair protein (RadC S100141_02411 ENOG4108Z03 MAF-like protein S100141_02413 ENOG4106A3R peptidase S100141_02414 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase S100141_02415 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) S100141_02417 ENOG4106AR7 Spore coat protein S100141_02418 ENOG41068KH stage VI sporulation protein D S100141_02419 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase S100141_02420 ENOG4105D52 delta-aminolevulinic acid dehydratase S100141_02422 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) S100141_02424 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) S100141_02426 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) S100141_02427 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) S100141_02428 ENOG4108IUQ atp-dependent protease S100141_02429 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) S100141_02430 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation S100141_02432 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) S100141_02433 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) S100141_02434 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) S100141_02435 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) S100141_02436 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase S100141_02437 ENOG4108ZP8 Acetolactate synthase small subunit S100141_02438 ENOG4105C7K acetolactate synthase S100141_02439 ENOG4105CM2 brancheD-chain amino acid aminotransferase S100141_02441 ENOG4107R37 Glutamate dehydrogenase S100141_02444 ENOG4108MDF Phage Portal Protein S100141_02445 ENOG4105IG6 Phage terminase, large subunit S100141_02458 ENOG4105M59 Phosphodiesterase, mj0936 family S100141_02459 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) S100141_02460 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) S100141_02461 ENOG4108XJQ germination protein S100141_02462 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) S100141_02463 ENOG41067TZ transcriptional regulator, MarR family S100141_02464 ENOG4105PFC Transcriptional regulator S100141_02465 ENOG4105EMU Dehydrogenase S100141_02467 ENOG4105E33 succinate dehydrogenase S100141_02469 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit S100141_02471 ENOG4105CFH Aspartokinase S100141_02472 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) S100141_02473 ENOG4105K63 Thioredoxin S100141_02474 ENOG4105C10 Electron transfer flavoprotein S100141_02475 ENOG4105BZJ Electron transfer flavoprotein S100141_02476 ENOG41060WC Enoyl-CoA hydratase S100141_02477 ENOG4107Z3H Transcriptional regulator, TetR family S100141_02478 ENOG4105CEY Amp-dependent synthetase and ligase S100141_02480 ENOG4105C98 muts2 protein S100141_02481 ENOG4105DCG PHP domain protein S100141_02483 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) S100141_02484 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) S100141_02486 ENOG4105DQ6 Transposase S100141_02490 ENOG4108IUZ ABC transporter S100141_02493 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) S100141_02494 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) S100141_02495 ENOG4108RWN rrna methyltransferase S100141_02496 ENOG41067MF small acid-soluble spore protein S100141_02501 ENOG4105DRS transport system, permease S100141_02504 ENOG4108MDK Dehydrogenase S100141_02505 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase S100141_02506 ENOG4105EF1 ribulokinase S100141_02507 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) S100141_02508 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase S100141_02509 ENOG4105CN9 Peptidase m42 family protein S100141_02511 ENOG410696E Membrane S100141_02512 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) S100141_02513 ENOG4105VJV 50s ribosomal protein L35 S100141_02514 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) S100141_02515 ENOG41067MG lrgb family S100141_02517 ENOG4105DGI Alkaline phosphatase S100141_02518 ENOG4105DY9 regulatoR S100141_02519 ENOG4108HRK Histidine kinase S100141_02521 ENOG4105U0R haloacid dehalogenase-like hydrolase S100141_02522 ENOG4105C22 threonyL-tRNA synthetase S100141_02523 ENOG4108TDW sporulation protein YtxC S100141_02528 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) S100141_02530 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) S100141_02531 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase S100141_02532 ENOG4108NR7 pectate lyase S100141_02533 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) S100141_02535 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) S100141_02536 ENOG4105C2M dna polymerase I S100141_02537 ENOG4105BZU Histidine kinase S100141_02538 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S100141_02539 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) S100141_02540 ENOG4108HMX isocitrate dehydrogenase (NADP) S100141_02541 ENOG4105BZN citrate synthase S100141_02542 ENOG4108VMM UPF0756 membrane protein S100141_02543 ENOG4108REF Sporulation integral membrane protein ytvi S100141_02544 ENOG4105FS0 cytoplasmic membrane protein S100141_02545 ENOG4105CA9 Pyruvate kinase S100141_02546 ENOG4105CTQ phosphohexokinase S100141_02547 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) S100141_02549 ENOG4105C6K Malic enzyme S100141_02550 ENOG4105C0B DNA polymerase III (alpha subunit) S100141_02551 ENOG4105VV2 S100141_02553 ENOG4106EVM S100141_02554 ENOG4105SFS phosphoesterase RecJ domain protein S100141_02557 ENOG4105U3E Transcriptional regulator S100141_02558 ENOG4105E8R UPF0173 metal-dependent hydrolase S100141_02561 ENOG4105CH7 arginosuccinase S100141_02562 ENOG4105CH7 arginosuccinase S100141_02563 ENOG4105CDH Citrulline--aspartate ligase S100141_02564 ENOG4105EPU Molybdenum cofactor synthesis domain protein S100141_02565 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) S100141_02567 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) S100141_02568 ENOG4105KBJ sporulation protein ytfj S100141_02570 ENOG4105VK3 rdd domain containing protein S100141_02571 ENOG4105D07 Signal peptide peptidase, SppA S100141_02573 ENOG4105CW7 secretion protein, HlyD family S100141_02576 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) S100141_02578 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) S100141_02583 ENOG4105DQ6 Transposase S100141_02586 ENOG4105U5Y Transcriptional regulator S100141_02588 ENOG4105BZU Histidine kinase S100141_02589 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) S100141_02592 ENOG4105KAF membrAne S100141_02593 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein S100141_02596 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) S100141_02598 ENOG4105F1V Acetoin utilization protein S100141_02599 ENOG4105W87 Cbs domain S100141_02600 ENOG4105DGU Histone deacetylase S100141_02601 ENOG4105ER2 Ompa motb domain protein S100141_02602 ENOG4107R0U MotA TolQ exbB proton channel S100141_02603 ENOG4105ETE Transcriptional regulator (LacI family S100141_02604 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase S100141_02610 ENOG4105DFU Cell wall formation (By similarity) S100141_02612 ENOG4108VDD TRNA binding domain protein S100141_02615 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ S100141_02618 ENOG4105C6K Malic enzyme S100141_02619 ENOG4105C8F Beta-lactamase domain protein S100141_02620 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) S100141_02622 ENOG4108V15 phosphotransferase enzyme family S100141_02623 ENOG4108IUM Glycogen debranching enzyme S100141_02624 ENOG4108IUM Glycogen debranching enzyme S100141_02627 ENOG4107F58 2'-5' rna ligase S100141_02628 ENOG4105C6T cysteine synthase S100141_02630 ENOG4107QSE Dipeptidase S100141_02631 ENOG4105C7N Xanthine uracil vitamin C permease S100141_02632 ENOG4105YW5 deoR family transcriptional regulator S100141_02635 ENOG4105CBX hi0933 family S100141_02636 ENOG4105C94 Transporter S100141_02638 ENOG41085GJ domain protein S100141_02642 ENOG4105MU9 integral membrane protein S100141_02643 ENOG4105DDC Oxidoreductase domain protein S100141_02645 ENOG4105F5H Glycosyl Hydrolase Family 88 S100141_02647 ENOG41075H3 AraC family transcriptional regulator S100141_02649 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component S100141_02651 ENOG4105NTD Inherit from COG: Hydrolase S100141_02653 ENOG4107V2S Transcriptional regulator S100141_02654 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase S100141_02655 ENOG4105C8T Leucyl-tRNA synthetase S100141_02657 ENOG410605W Major Facilitator S100141_02658 ENOG4105D01 (LipO)protein S100141_02659 ENOG4106UBQ S100141_02660 ENOG4107R34 abc transporter permease protein S100141_02661 ENOG4105C19 ABC transporter S100141_02663 ENOG4105DVE abc transporter atp-binding protein S100141_02664 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family S100141_02667 ENOG4105N5T Radical SAM Protein S100141_02671 ENOG4105E8V Alpha Beta Hydrolase Fold protein S100141_02672 ENOG4108Z0R Transferase S100141_02673 ENOG4105YVM Phosphoesterase, PA-phosphatase related S100141_02674 ENOG4105BZF Glycosyl transferase (Group 1 S100141_02675 ENOG4105CAQ asparagine synthetase S100141_02676 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP S100141_02681 ENOG4105D2X ABC transporter substrate-binding protein S100141_02683 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component S100141_02687 ENOG4108RMU ferritin dps family protein S100141_02690 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) S100141_02691 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) S100141_02692 ENOG4108V2W Carbonate dehydratase S100141_02693 ENOG4105CKI cobalamin synthesis protein S100141_02694 ENOG4105DSE periplasmic solute binding protein S100141_02700 ENOG4105DTQ mandelate racemase muconate lactonizing S100141_02701 ENOG4105CEY Amp-dependent synthetase and ligase S100141_02702 ENOG4108IPT Naphthoate synthase S100141_02703 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) S100141_02704 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) S100141_02705 ENOG4105E4F Isochorismate synthase S100141_02706 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase S100141_02711 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) S100141_02713 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) S100141_02714 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) S100141_02739 ENOG4105CMD Transcriptional regulator, GntR family S100141_02740 ENOG4105CMD Transcriptional regulator, GntR family S100141_02741 ENOG4105N67 Proton-coupled thiamine transporter YuaJ S100141_02747 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) S100141_02749 ENOG4105CZN Potassium uptake protein S100141_02751 ENOG4106DF1 S100141_02752 ENOG4108VNY MOSC domain protein S100141_02753 ENOG4108JB8 alcohol dehydrogenase S100141_02754 ENOG4105C26 Dehydrogenase S100141_02755 ENOG4105TRT Transcriptional regulator S100141_02757 ENOG4105JQZ Methyltransferase S100141_02758 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) S100141_02759 ENOG4105F0F Oxalate decarboxylase S100141_02771 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) S100141_02777 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) S100141_02779 ENOG4105EE0 oxidoreductase S100141_02780 ENOG4108Z0Z intracellular protease Pfpi family S100141_02781 ENOG4105C8Q Methyl-accepting chemotaxis S100141_02782 ENOG4105C8Q Methyl-accepting chemotaxis S100141_02783 ENOG4105C8Q Methyl-accepting chemotaxis S100141_02784 ENOG4105C8Q Methyl-accepting chemotaxis S100141_02786 ENOG4105EA8 2-Nitropropane dioxygenase S100141_02787 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme S100141_02792 ENOG4105C37 (CBS) domain S100141_02795 ENOG4107PBV potassium channel S100141_02796 ENOG4107PBV potassium channel S100141_02798 ENOG410900G Protein of unknown function (DUF421) S100141_02800 ENOG4105KNA -acetyltransferase S100141_02808 ENOG4107EV6 Inherit from COG: YD repeat protein S100141_02815 ENOG41068G1 S100141_02817 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj S100141_02819 ENOG4108FKH Transglycosylase SLT domain S100141_02829 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S100141_02832 ENOG4105CAR Terminase, large subunit S100141_02857 ENOG4107QYV phosphohexose isomerase S100141_02858 ENOG4107QW4 alcohol dehydrogenase S100141_02859 ENOG4105WG9 Conserved Protein S100141_02861 ENOG4105CHM Aminotransferase S100141_02862 ENOG4108ZB6 transcriptional regulator AsnC family S100141_02863 ENOG4108MUZ hydrolase S100141_02866 ENOG4105C87 Aminotransferase class I and II S100141_02868 ENOG4105Y38 Kinase-associated protein B S100141_02871 ENOG4105BZ4 penicillin-binding protein S100141_02872 ENOG4105KIR Thiol-disulfide oxidoreductase dcc S100141_02876 ENOG4108MRH transcriptional regulatory protein S100141_02877 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase S100141_02878 ENOG4107ZTW SNARE associated Golgi S100141_02879 ENOG4105DJ4 phosphatidylserine decarboxylase S100141_02880 ENOG4105DJ4 phosphatidylserine decarboxylase S100141_02883 ENOG4105D65 subunit l S100141_02884 ENOG4105HC0 Na H antiporter S100141_02885 ENOG4108ZE9 Monovalent cation H antiporter subunit C S100141_02886 ENOG4108JPZ Monovalent cation H antiporter subunit D S100141_02887 ENOG4105SC1 monovalent cation H antiporter subunit E S100141_02889 ENOG4105KJM monovalent cation h antiporter subunit g S100141_02890 ENOG4105KA0 thioesterase Superfamily protein S100141_02892 ENOG4105BZU Histidine kinase S100141_02898 ENOG4105D58 Diguanylate phosphodiesterase S100141_02899 ENOG4105DAP Nicotinate phosphoribosyltransferase S100141_02904 ENOG4105C02 permease S100141_02905 ENOG4108Z40 Transcriptional regulator S100141_02909 ENOG410904N short-chain dehydrogenase reductase S100141_02916 ENOG4105BZG amino acid carrier protein S100141_02917 ENOG4108K8K Transcriptional regulator S100141_02918 ENOG4105DCF alanine dehydrogenase S100141_02923 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) S100141_02925 ENOG41069ER domain protein S100141_02927 ENOG4105CEP NADH dehydrogenase S100141_02928 ENOG4105CAY ferredoxin--nadp reductase S100141_02931 ENOG4108YM7 Gcn5-related n-acetyltransferase S100141_02932 ENOG4108YX9 iron--sulfur cluster insertion protein erpA S100141_02937 ENOG4108ZMX Domain of unknown function (DU1801) S100141_02940 ENOG4105PY6 Phenolic acid decarboxylase S100141_02943 ENOG41083MR nifu domain-containing protein S100141_02944 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein S100141_02945 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) S100141_02946 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) S100141_02947 ENOG4105D6E homoserine dehydrogenase S100141_02948 ENOG4105C5I Dehydrogenase S100141_02950 ENOG4108W5N phosphatidylglycerophosphatase a S100141_02951 ENOG4105D4U had-superfamily hydrolase, subfamily iia S100141_02953 ENOG4105MMD transcriptional regulator S100141_02954 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) S100141_02955 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) S100141_02956 ENOG4105FAA peptidase M23 S100141_02958 ENOG4105C8J )-transporter S100141_02959 ENOG4108YTE sporulation protein YunB S100141_02960 ENOG4105KZD Domain of unknown function (DUF1805) S100141_02961 ENOG4107R8B 5'-nucleotidase S100141_02963 ENOG4105I3N Conserved Protein S100141_02964 ENOG4105IIP Membrane S100141_02965 ENOG4105W1N transcriptional regulator S100141_02967 ENOG4105C5R Aminotransferase S100141_02969 ENOG4105G9B Transcriptional regulator S100141_02973 ENOG4108I0Q anthranilate phosphoribosyltransferase S100141_02974 ENOG4108K8S endonuclease I S100141_02976 ENOG4107VFR oxidoreductase S100141_02981 ENOG4105DIW FeS assembly protein SUFB S100141_02982 ENOG4108UNV SUF system FeS assembly protein, NifU family S100141_02983 ENOG4105C9B Cysteine desulfurase S100141_02984 ENOG4105JRK feS assembly protein SufD S100141_02985 ENOG4105C3K feS assembly ATPase SufC S100141_02986 ENOG4105PGM cation diffusion facilitator family transporter S100141_02988 ENOG4105D01 (LipO)protein S100141_02989 ENOG4108UMI ABC transporter, permease S100141_02990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) S100141_02995 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) S100141_02996 ENOG41080E8 Transcriptional regulator, Spx MgsR family S100141_02997 ENOG4105C1G acyl-Coa dehydrogenase S100141_02998 ENOG4105CHU acetyl-coa acetyltransferase S100141_03005 ENOG4105E0A ABC, transporter S100141_03006 ENOG4108IHU transport system permease protein S100141_03007 ENOG4105DQ5 transport system permease protein S100141_03008 ENOG4108MES Periplasmic binding protein S100141_03011 ENOG4105DZ1 carboxypeptidase S100141_03012 ENOG4105E1F short-chain dehydrogenase reductase S100141_03013 ENOG4105HUF DNA protection during starvation protein S100141_03014 ENOG4105C0H protease S100141_03016 ENOG4105F3H Histidine kinase S100141_03018 ENOG41067SE Tetr family transcriptional regulator S100141_03019 ENOG4105C9Q fumarate hydratase class II S100141_03025 ENOG4105WH1 Two component transcriptional regulator luxr family S100141_03026 ENOG4105ENE Histidine kinase S100141_03029 ENOG41087YS Phage shock protein A S100141_03032 ENOG4108WBT adenosyltransferase S100141_03033 ENOG4105CHR reductase S100141_03034 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) S100141_03035 ENOG4105C0A alcohol dehydrogenase S100141_03036 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) S100141_03037 ENOG4105E0A ABC, transporter S100141_03038 ENOG4105EHG Permease protein S100141_03039 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) S100141_03040 ENOG4105DRR Transcriptional regulator, GntR family S100141_03041 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S100141_03042 ENOG4108RPX mosc domain containing protein S100141_03043 ENOG4105DND Transcriptional regulator S100141_03045 ENOG4105CTX dehydratase S100141_03046 ENOG4107QZW Altronate oxidoreductase S100141_03047 ENOG4107KJX Transcriptional regulator S100141_03048 ENOG4105CT4 transporter S100141_03049 ENOG4105D2H Uronic isomerase S100141_03051 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S100141_03052 ENOG4105E0A ABC, transporter S100141_03053 ENOG4105EHG Permease protein S100141_03054 ENOG4105DQ5 transport system permease protein S100141_03055 ENOG4105D5Q Arginine ornithine antiporter S100141_03057 ENOG4107K5X Membrane-bound metal-dependent hydrolase S100141_03058 ENOG4107QZ2 Sulfatase S100141_03061 ENOG4105EVU fructokinase S100141_03062 ENOG4107EPV Aminotransferase class V S100141_03064 ENOG4105EEM helicase S100141_03065 ENOG4105EN6 Membrane S100141_03066 ENOG4105RHY Pfam:UPF0157 S100141_03068 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) S100141_03070 ENOG4107ZQN disulfide bond S100141_03071 ENOG4105C59 p-type ATPase S100141_03072 ENOG4108JE9 extracellular solute-binding protein family 1 S100141_03073 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component S100141_03074 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component S100141_03075 ENOG4105CJQ hydrolase, family 31 S100141_03077 ENOG4105DIK (ABC) transporter S100141_03078 ENOG4105CC5 ABC transporter S100141_03079 ENOG4105DSE periplasmic solute binding protein S100141_03083 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) S100141_03084 ENOG4105DM4 PTS System S100141_03088 ENOG4105C59 p-type ATPase S100141_03089 ENOG410681U heavy metal transport detoxification protein S100141_03090 ENOG4105VPX protein, conserved in bacteria S100141_03091 ENOG4107RKG DJ-1/PfpI family S100141_03092 ENOG4105E98 transcriptional regulator DeoR family S100141_03093 ENOG4105DET Rhamnulokinase S100141_03094 ENOG4105C9F isomerase S100141_03097 ENOG4105F27 Major Facilitator S100141_03100 ENOG410625E S100141_03101 ENOG4106A3M Cytochrome p-450 S100141_03105 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) S100141_03106 ENOG4105D9R oxidoreductase S100141_03109 ENOG4105C72 UPF0176 protein S100141_03111 ENOG4106DF4 Sigma-70, region 4 S100141_03113 ENOG4105F0F Oxalate decarboxylase S100141_03123 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) S100141_03124 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) S100141_03126 ENOG4105XZU Preprotein translocase, subunit SecG S100141_03131 ENOG4105R40 Glycine betaine carnitine choline S100141_03132 ENOG4108HQR Glycine betaine S100141_03133 ENOG4105E90 ABC transporter S100141_03134 ENOG4108IJ8 ABC transporter S100141_03135 ENOG4107HG4 Transcriptional regulator S100141_03136 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein S100141_03138 ENOG4105T65 Membrane-associated protein S100141_03140 ENOG4108MES Periplasmic binding protein S100141_03142 ENOG4108V4B ThiJ pfpI S100141_03143 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) S100141_03144 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) S100141_03145 ENOG4105CP7 Triose-phosphate isomerase S100141_03146 ENOG4105BZA Phosphoglycerate kinase S100141_03147 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase S100141_03149 ENOG4105DEN Luciferase family S100141_03156 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) S100141_03157 ENOG4105JXH GntR family transcriptional regulator S100141_03158 ENOG4105DAA L-lactate S100141_03159 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_03161 ENOG4108ZPC Polysaccharide pyruvyl transferase S100141_03162 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase S100141_03163 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family S100141_03164 ENOG4105D3Q Sugar transferase S100141_03166 ENOG4105K64 Glycosyl transferase, family 2 S100141_03168 ENOG4107QRS glycosyltransferase group 2 family protein S100141_03169 ENOG41068W6 Capsular polysaccharide biosynthesis protein S100141_03170 ENOG4108KMV Glycosyl transferase (Group 1 S100141_03171 ENOG4105K64 Glycosyl transferase, family 2 S100141_03172 ENOG4108PQP glycosyl transferase group 1 S100141_03174 ENOG4108QV3 biosynthesis protein S100141_03175 ENOG4105HTX biosynthesis protein S100141_03177 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein S100141_03178 ENOG4108I5G Major Facilitator superfamily S100141_03180 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) S100141_03181 ENOG4107S2N Type III effector Hrp-dependent S100141_03183 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) S100141_03186 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S100141_03187 ENOG4105EDQ levansucrase EC 2.4.1.10 S100141_03188 ENOG4108HKT sucrose-6-phosphate hydrolase S100141_03191 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S100141_03192 ENOG4108URH decarboxylase S100141_03193 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain S100141_03194 ENOG4107TVP HD domain protein S100141_03195 ENOG4105CHH sulfate transporter S100141_03196 ENOG4108V2W Carbonate dehydratase S100141_03197 ENOG4105C5I Dehydrogenase S100141_03198 ENOG4108SQ9 flavin reductase domain protein, FMN-binding S100141_03199 ENOG4108ZHR arsR family transcriptional regulator S100141_03202 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase S100141_03203 ENOG4105KRI phosphocarrier protein (HPr S100141_03204 ENOG4105CIE May be required for sporulation (By similarity) S100141_03205 ENOG4105CHW UPF0052 protein S100141_03206 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) S100141_03207 ENOG4108Z4K mutator MutT protein S100141_03208 ENOG4105C3M thioredoxin reductase S100141_03211 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase S100141_03212 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) S100141_03213 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase S100141_03214 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) S100141_03215 ENOG4105ECC imidazole-glycerol-phosphate dehydratase S100141_03216 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) S100141_03217 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) S100141_03218 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) S100141_03220 ENOG4108E16 pectate lyase S100141_03221 ENOG4108S4C acetyltransferase S100141_03222 ENOG4107XGZ Hydrolase S100141_03223 ENOG4105HKU nucleoside recognition domain-containing protein S100141_03225 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) S100141_03226 ENOG410834F Transcriptional regulator S100141_03227 ENOG4105C0R drug resistance transporter emrb qaca subfamily S100141_03228 ENOG41088CQ domain protein S100141_03229 ENOG41086DT Membrane protein of unknown function S100141_03230 ENOG41067S9 phage shock protein C, PspC S100141_03231 ENOG4108PY7 S100141_03235 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) S100141_03236 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) S100141_03241 ENOG4105CN1 protease S100141_03242 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) S100141_03244 ENOG4105CRP Part of the ABC transporter FtsEX involved in S100141_03245 ENOG4105CAK Cell division ATP-binding protein ftsE S100141_03248 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) S100141_03249 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving S100141_03250 ENOG4105MS2 ribosomal subunit Interface protein S100141_03253 ENOG4105MQ3 flagellar protein FliS S100141_03254 ENOG4107RT6 flagellar hook-associated S100141_03255 ENOG41083S7 flagellar protein FlaG S100141_03256 ENOG4105I03 Flagellin S100141_03257 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) S100141_03258 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) S100141_03259 ENOG4105MKD S100141_03260 ENOG4105DTJ flagellar hook-associated protein S100141_03261 ENOG4105E1Q flagellar hook-associated protein S100141_03264 ENOG4105RU3 S100141_03268 ENOG4105WH1 Two component transcriptional regulator luxr family S100141_03269 ENOG4105BZU Histidine kinase S100141_03270 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein S100141_03271 ENOG4108KGH TRANSCRIPTIONal S100141_03273 ENOG4105ESV Glycosyl transferase, family 4 S100141_03274 ENOG4107EF8 Glycosyl transferase (Group 1 S100141_03277 ENOG4105QZI O-Antigen Polymerase S100141_03278 ENOG4105C1B dTDP-glucose 4-6-dehydratase S100141_03279 ENOG4105C6Y Udp-glucose 6-dehydrogenase S100141_03280 ENOG4107RA4 Glycosyl transferase (Group 1 S100141_03281 ENOG4105PSV Polysaccharide Biosynthesis Protein S100141_03282 ENOG4105D3Q Sugar transferase S100141_03283 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S100141_03284 ENOG4105JFG SpoIID LytB domain protein S100141_03286 ENOG4108KGH TRANSCRIPTIONal S100141_03287 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase S100141_03288 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase S100141_03289 ENOG4105EY8 ABC transporter S100141_03292 ENOG4107SJB teichoic acid biosynthesis S100141_03293 ENOG4107SJB teichoic acid biosynthesis S100141_03294 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase S100141_03296 ENOG4107RZX Teichoic acid biosynthesis protein S100141_03298 ENOG4105DG6 mannose-6-phosphate isomerase S100141_03300 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase S100141_03301 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) S100141_03302 ENOG4108UHU Aldolase S100141_03303 ENOG4105D7K pfkb domain protein S100141_03304 ENOG4108M60 Transcriptional regulator S100141_03306 ENOG4105CHR reductase S100141_03307 ENOG4105E2A Dehydrogenase S100141_03309 ENOG4105C54 Major Facilitator superfamily S100141_03310 ENOG4105C54 Major Facilitator superfamily S100141_03311 ENOG4108KGH TRANSCRIPTIONal S100141_03312 ENOG4105J7I hydrolase S100141_03313 ENOG4105K4H Nlp p60 protein S100141_03315 ENOG4105PNM synthesis protein S100141_03317 ENOG4105N98 Capsule biosynthesis protein capB S100141_03318 ENOG4105ETE Transcriptional regulator (LacI family S100141_03319 ENOG4108RVA ribokinase S100141_03320 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) S100141_03321 ENOG4105C2J ABC transporter S100141_03322 ENOG4105CNN ABC, transporter S100141_03323 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator S100141_03324 ENOG4107FQX Alpha-acetolactate decarboxylase S100141_03326 ENOG4107RSM transcriptional regulator S100141_03327 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) S100141_03329 ENOG4105CAH Chromate S100141_03330 ENOG4105FGV Chromate S100141_03331 ENOG4108RB3 Capsular polysaccharide biosynthesis protein S100141_03332 ENOG4105HTX biosynthesis protein S100141_03334 ENOG4105KBK Zinc finger, swim domain protein S100141_03335 ENOG4105C0D helicase S100141_03337 ENOG410667J hydrolase S100141_03338 ENOG4105E98 transcriptional regulator DeoR family S100141_03340 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase S100141_03341 ENOG4105VI0 Pts system, glucitol sorbitol-specific S100141_03342 ENOG4105DZY Pts system, glucitol sorbitol-specific S100141_03343 ENOG410787A Pts system, glucitol sorbitol-specific S100141_03345 ENOG4105DKT Transcriptional regulator S100141_03346 ENOG4105Z8H single-stranded DNA-binding protein S100141_03350 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) S100141_03351 ENOG4105CGA flagellar basal-body rod protein FlgG S100141_03353 ENOG4105DFF Rod shape-determining protein mreb S100141_03354 ENOG4105MT0 Sporulation transcriptional regulator spoiiid S100141_03355 ENOG4107MII Sugar-specific transcriptional regulator TrmB S100141_03356 ENOG4105CZM Major Facilitator S100141_03357 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase S100141_03358 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase S100141_03360 ENOG4108NA0 Uncharacterized conserved protein (COG2071) S100141_03361 ENOG41080XP Cbs domain S100141_03362 ENOG41080XQ Signal transduction protein with cbs domains S100141_03364 ENOG4105C37 (CBS) domain S100141_03365 ENOG4105BZU Histidine kinase S100141_03369 ENOG4105FRN stage II sporulation protein S100141_03370 ENOG4107TCE N-acetyltransferase S100141_03372 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S100141_03374 ENOG4105C0R drug resistance transporter emrb qaca subfamily S100141_03375 ENOG4105WQT MbtH domain protein S100141_03376 ENOG4105CEY Amp-dependent synthetase and ligase S100141_03377 ENOG4105WQI isochorismatase S100141_03378 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase S100141_03379 ENOG4105E4F Isochorismate synthase S100141_03380 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase S100141_03381 ENOG4105NIV Esterase S100141_03385 ENOG410874W AraC family transcriptional regulator S100141_03387 ENOG4108RYK Nad-dependent epimerase dehydratase S100141_03388 ENOG4108Z40 Transcriptional regulator S100141_03391 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) S100141_03392 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) S100141_03393 ENOG4105FCD Major Facilitator S100141_03394 ENOG4108HIZ formate dehydrogenase alpha subunit S100141_03395 ENOG4108TF4 von Willebrand factor, type A S100141_03398 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) S100141_03400 ENOG4106778 Protein of unknown function (DUF1146) S100141_03401 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) S100141_03402 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) S100141_03403 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) S100141_03404 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) S100141_03405 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) S100141_03408 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) S100141_03410 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) S100141_03411 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) S100141_03412 ENOG4108UIC UPF0340 protein S100141_03413 ENOG4108YZG isomerase S100141_03414 ENOG4107WAU Protein tyrosine phosphatase S100141_03415 ENOG410815N Probably functions as a manganese efflux pump (By similarity) S100141_03416 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) S100141_03418 ENOG4108ZXQ stage ii sporulation protein r S100141_03421 ENOG4105TRI Hydrolase S100141_03424 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) S100141_03425 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) S100141_03426 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase S100141_03428 ENOG4107TT2 Auxin Efflux Carrier S100141_03429 ENOG4105C6K Malic enzyme S100141_03430 ENOG4107104 thymidine kinase S100141_03431 ENOG41082DI 50s ribosomal protein l31 S100141_03432 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) S100141_03433 ENOG4105CBT Fructose-1,6-bisphosphatase S100141_03434 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) S100141_03435 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway S100141_03436 ENOG4105D2N Aldolase S100141_03437 ENOG410812K response regulator receiver protein S100141_03441 ENOG4105DQ6 Transposase S100141_03442 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) S100141_03444 ENOG4105C1G acyl-Coa dehydrogenase S100141_03445 ENOG4105C1G acyl-Coa dehydrogenase S100141_03446 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase S100141_03448 ENOG4105DF6 Fe-S oxidoreductase S100141_03451 ENOG4105C75 arginyL-tRNA synthetase S100141_03452 ENOG410684U Domain of unknown function (DUF1934) S100141_03453 ENOG4105CYW agmatinase S100141_03454 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) S100141_03456 ENOG4105BZ4 penicillin-binding protein S100141_03457 ENOG4108XFG YwhD family S100141_03458 ENOG4108Z4T Peptidase M50 S100141_03459 ENOG41069HH 4-oxalocrotonate tautomerase S100141_03462 ENOG4105DCI Phosphohydrolase S100141_03464 ENOG4108VCI transcription factor, rsfa family S100141_03466 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) S100141_03468 ENOG4105D2S major facilitator superfamily S100141_03473 ENOG4108FUF Transcriptional regulator, IclR family S100141_03475 ENOG4108IJ2 phosphate acetyltransferase S100141_03476 ENOG4107JTW chlorite dismutase S100141_03478 ENOG4105CZN Potassium uptake protein S100141_03482 ENOG4105CJ1 ABC, transporter S100141_03488 ENOG4105C26 Dehydrogenase S100141_03489 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) S100141_03490 ENOG4108RJ9 Glycosyl transferase, family 2 S100141_03491 ENOG4105DWF phosphomethylpyrimidine kinase S100141_03494 ENOG4105C5Y PTS System S100141_03498 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin S100141_03500 ENOG4105DEN Luciferase family S100141_03502 ENOG4108DBC nitroreductase S100141_03506 ENOG4105DWD nucleoside recognition domain protein S100141_03518 ENOG41060D1 Quinol oxidase S100141_03520 ENOG4105BZ9 Cytochrome C oxidase, subunit I S100141_03521 ENOG4105E2S oxidase) subunit II S100141_03522 ENOG4105CMR udp-glucose 4-epimerase S100141_03526 ENOG4108WS4 fmn reductase S100141_03529 ENOG4105CMG Carbohydrate kinase S100141_03530 ENOG4105C93 Xylose Isomerase S100141_03532 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) S100141_03533 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase S100141_03534 ENOG4105CMU LysR family (Transcriptional regulator S100141_03538 ENOG41067MG lrgb family S100141_03540 ENOG4105CK7 Sodium proline symporter S100141_03541 ENOG4105DR4 Methyltransferase S100141_03543 ENOG4105C5I Dehydrogenase S100141_03544 ENOG4105X1N Glycosyl transferase family 8 S100141_03546 ENOG4105ENE Histidine kinase S100141_03547 ENOG4108VB1 regulatoR S100141_03548 ENOG4105EYF MMPL domain protein S100141_03550 ENOG4105DJB Major Facilitator Superfamily S100141_03551 ENOG4105CXK mandelate racemase muconate lactonizing S100141_03552 ENOG4108UHU Aldolase S100141_03553 ENOG4105D7K pfkb domain protein S100141_03555 ENOG4105IIU Aminopeptidase S100141_03556 ENOG41080V3 Major Facilitator superfamily S100141_03561 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) S100141_03562 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein S100141_03563 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) S100141_03564 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD S100141_03565 ENOG4105CM2 brancheD-chain amino acid aminotransferase S100141_03567 ENOG4105F8D glycoside hydrolase family 4 S100141_03568 ENOG4105VCP PTS System S100141_03569 ENOG4105CK1 PTS System S100141_03570 ENOG4105VZJ PTS System S100141_03571 ENOG4105EMD TRANSCRIPTIONal S100141_03573 ENOG4108VX5 3-methyladenine DNA glycosylase S100141_03576 ENOG4105DXD 2-methylcitrate dehydratase S100141_03577 ENOG4105CR4 methylisocitrate lyase S100141_03580 ENOG4105BZ1 (ABC) transporter S100141_03581 ENOG4107TDE lipolytic protein G-D-S-L family S100141_03584 ENOG4105C2C drug resistance transporter, Bcr CflA S100141_03586 ENOG4105DA5 (ABC) transporter S100141_03587 ENOG41069JR S100141_03592 ENOG4105CH6 catalase S100141_03594 ENOG4105G5W regulator Fur family S100141_03595 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) S100141_03596 ENOG4108TU7 Inherit from COG: (ABC) transporter S100141_03597 ENOG4105CJ1 ABC, transporter S100141_03600 ENOG4105CJ1 ABC, transporter S100141_03610 ENOG4108J20 pectate lyase S100141_03611 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) S100141_03612 ENOG4108JJ8 (ABC) transporter S100141_03613 ENOG4108JJ9 ABC, transporter S100141_03614 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii S100141_03615 ENOG4105C4M (Ubiquinol oxidase) subunit I S100141_03616 ENOG4108QTI )-transporter S100141_03619 ENOG4105DFD Na H antiporter S100141_03620 ENOG4108IJ0 Aspartate ammonia-lyase S100141_03621 ENOG4105HDK L-asparaginase S100141_03622 ENOG4108IMY Transcriptional regulator S100141_03623 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) S100141_03631 ENOG4107BJW polysaccharide deacetylase S100141_03632 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S100141_03633 ENOG4107QZ7 Cellulose synthase catalytic subunit S100141_03635 ENOG4105DQ6 Transposase S100141_03636 ENOG4105D2K citrate carrier protein S100141_03637 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S100141_03638 ENOG4105X3H Excalibur domain protein S100141_03640 ENOG4105E0M Sulfatase S100141_03642 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) S100141_03644 ENOG4105CEU Arginine dihydrolase S100141_03645 ENOG4105DBV ornithine carbamoyltransferase S100141_03647 ENOG4105C5B carbamate kinase S100141_03649 ENOG4105CS2 ec 3.2.1.21 S100141_03650 ENOG4105CK1 PTS System S100141_03652 ENOG4105JVQ RNA Polymerase S100141_03657 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) S100141_03658 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) S100141_03660 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) S100141_03661 ENOG4105ETE Transcriptional regulator (LacI family S100141_03666 ENOG4105EDW glycosyl transferase, family 39 S100141_03667 ENOG4105CKK Glycosyl transferase, family 2 S100141_03668 ENOG4105CMR udp-glucose 4-epimerase S100141_03675 ENOG4105CH6 catalase S100141_03676 ENOG4105CH6 catalase S100141_03678 ENOG4105CS2 ec 3.2.1.21 S100141_03679 ENOG4105C5Y PTS System S100141_03680 ENOG4105CID antiterminator S100141_03681 ENOG4108W7F transporter, permease S100141_03682 ENOG4108JJB ABC transporter S100141_03683 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein S100141_03684 ENOG4105ETU transcriptional activator (TenA S100141_03687 ENOG4107QP3 malate synthase g S100141_03689 ENOG4105EDW glycosyl transferase, family 39 S100141_03691 ENOG4105C19 ABC transporter S100141_03692 ENOG4105EWM Histidine kinase S100141_03694 ENOG4105CS2 ec 3.2.1.21 S100141_03695 ENOG4105C5Y PTS System S100141_03697 ENOG4107QHE Choloylglycine hydrolase S100141_03700 ENOG4106Z5D Glycoside Hydrolase Family 43 S100141_03706 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) S100141_03707 ENOG4105D9N nucleoside S100141_03708 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) S100141_03709 ENOG4107RHR regulatoR S100141_03713 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) S100141_03714 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) S100141_03715 ENOG4107R8N Glycosyl transferase, family 2 S100141_03717 ENOG4105JKW Valine--pyruvate aminotransferase S100141_03722 ENOG4105D2N Aldolase S100141_03723 ENOG4107TRN Xylose isomerase domain protein TIM barrel S100141_03724 ENOG4105F0H myo-inositol catabolism protein S100141_03725 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S100141_03727 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) S100141_03728 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) S100141_03729 ENOG4105D7K pfkb domain protein S100141_03730 ENOG4105DH8 myo-inositol catabolism S100141_03731 ENOG4105C26 Dehydrogenase S100141_03733 ENOG4105CPC Aldo Keto reductase S100141_03734 ENOG4107VXM glycerophosphoryl diester phosphodiesterase S100141_03735 ENOG4105CXY transporter S100141_03736 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) S100141_03737 ENOG4105C5H ABC transporter S100141_03738 ENOG410667J hydrolase S100141_03741 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) S100141_03743 ENOG4108V5C ABC transporter S100141_03744 ENOG4108V5C ABC transporter S100141_03749 ENOG4105H93 Acyltransferase family S100141_03755 ENOG4105EC8 Methyl-accepting chemotaxis S100141_03756 ENOG4105BZG amino acid carrier protein S100141_03757 ENOG4105DCF alanine dehydrogenase S100141_03760 ENOG4105EG2 ABC transporter, permease S100141_03762 ENOG4107FKK extracellular solute-binding protein family 1 S100141_03764 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) S100141_03765 ENOG4105CMR udp-glucose 4-epimerase S100141_03766 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase S100141_03767 ENOG4105E2R ROK family S100141_03769 ENOG4105CMG Carbohydrate kinase S100141_03772 ENOG4108EKI Dehydrogenase S100141_03773 ENOG4105D3R alkyl hydroperoxide reductase S100141_03774 ENOG4105D3R alkyl hydroperoxide reductase S100141_03775 ENOG4108JU3 Alkyl hydroperoxide reductase S100141_03780 ENOG4108M15 ABC transporter S100141_03781 ENOG4105KCT ABC transporter S100141_03782 ENOG4105BZU Histidine kinase S100141_03783 ENOG4105BZU Histidine kinase S100141_03790 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) S100141_03793 ENOG4105WQG acetyltransferase S100141_03796 ENOG4105C0H protease S100141_03797 ENOG4105Q2H domain protein S100141_03800 ENOG4105BZU Histidine kinase S100141_03801 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S100141_03807 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis S100141_03809 ENOG4105CDU Replicative dna helicase S100141_03813 ENOG4105DJ2 Major Facilitator Superfamily S100141_03814 ENOG4105CE4 GlcNAc 6-P deacetylase S100141_03815 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) S100141_03816 ENOG4105FDP GntR family transcriptional regulator S100141_03817 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate S100141_03819 ENOG4105K9Q Binds to the 23S rRNA (By similarity) S100141_03820 ENOG4105BZR domain protein S100141_03821 ENOG4108XMW Membrane S100141_03823 ENOG4107YZX Universal stress protein S100141_03824 ENOG4105CHH sulfate transporter S100141_03826 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) S100141_03827 ENOG4108UUM single-stranded DNA-binding protein S100141_03828 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) S100141_03829 ENOG4105C3G gtp-binding protein S100141_03830 ENOG4105VDK protein, conserved in bacteria S100141_03832 ENOG4108ZDA Sporulation protein YyaC S100141_03833 ENOG4105FA0 parb-like partition protein S100141_03834 ENOG4107QJE Chromosome Partitioning Protein S100141_03835 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) S100141_03837 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) S100141_03839 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) S100141_03840 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) S100141_03843 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) S100141_03844 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) S100141_03845 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) S100141_03846 ENOG410848D S4 domain protein YaaA S100141_03847 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) S100141_03848 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S100141_03849 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S100141_03856 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) S100141_03858 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) S100141_03859 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) S100141_03860 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) S100141_03861 ENOG4105BZW Glycerate kinase S100141_03862 ENOG4107QQ0 gntp family S100141_03863 ENOG4107QQ0 gntp family S100141_03864 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR S100141_03867 ENOG4105ZMH deoxynucleoside kinase S100141_03869 ENOG4105VRS hydrolase family 18 S100141_03870 ENOG4105GTG Isochorismatase S100141_03871 ENOG4108Z6B deaminase S100141_03872 ENOG4105C6E dna polymerase iii S100141_03873 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) S100141_03874 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) S100141_03876 ENOG41067KS pro-sigma K processing S100141_03884 ENOG4105CDW Resistance protein S100141_03885 ENOG4105CXN decarboxylase S100141_03886 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) S100141_03887 ENOG4105X0R protein from nitrogen regulatory protein P-II S100141_03888 ENOG4105XVJ Protein of unknown function (DUF327) S100141_03889 ENOG4105FA2 dna polymerase iii S100141_03890 ENOG4105MA4 psp1 domain protein S100141_03891 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) S100141_03892 ENOG41060K3 Methyltransferase S100141_03893 ENOG4105VC4 domain protein S100141_03894 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) S100141_03895 ENOG4105KRN Transcriptional regulator, abrb family S100141_03896 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) S100141_03897 ENOG4105F8V Hydrolase, tatD family S100141_03898 ENOG41069ER domain protein S100141_03900 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) S100141_03901 ENOG4105XFA sporulation peptidase YabG S100141_03902 ENOG4105W42 Veg protein S100141_03903 ENOG4105XEW small acid-soluble spore protein S100141_03905 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) S100141_03906 ENOG4105DFT pur operon repressor S100141_03907 ENOG4105KME endoribonuclease L-psp S100141_03908 ENOG4105K4W Could be involved in septation (By similarity) S100141_03909 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) S100141_03910 ENOG4105C5T Phosphoribosyl pyrophosphate synthase S100141_03911 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) S100141_03914 ENOG4108JA2 transcriptioN-repair coupling factor S100141_03915 ENOG4108M14 stage v sporulation protein t S100141_03917 ENOG4108IY2 MazG family S100141_03918 ENOG41082I2 s4 domain protein S100141_03919 ENOG4105VYY sporulation protein yabp S100141_03922 ENOG41060GV RNA binding s1 domain protein S100141_03928 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) S100141_03929 ENOG4108UGV hypoxanthine phosphoribosyltransferase S100141_03930 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) S100141_03931 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) S100141_03932 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) S100141_03933 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) S100141_03934 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase S100141_03935 ENOG4105C6T cysteine synthase S100141_03936 ENOG4105CRQ synthase (Component I) S100141_03937 ENOG4105DDQ anthranilate synthase S100141_03938 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 S100141_03939 ENOG4105EEI dihydropteroate synthase S100141_03940 ENOG4105KRF dihydroneopterin aldolase S100141_03941 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase S100141_03943 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) S100141_03944 ENOG4105CRK lysyL-tRNA synthetase S100141_03961 ENOG4108Z0C Uvrb UvrC protein S100141_03962 ENOG41066A3 ATP guanido phosphotransferase S100141_03964 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) S100141_03965 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) S100141_03966 ENOG4105CTP PilT protein domain protein S100141_03967 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) S100141_03968 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) S100141_03969 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) S100141_03970 ENOG4105D7W serine acetyltransferase S100141_03971 ENOG4105C8N cysteinyl-tRNA synthetase S100141_03972 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) S100141_03973 ENOG4105C2N RNA methyltransferase TrmH family group 3 S100141_03974 ENOG4105M0M Tetracycline resistance protein S100141_03975 ENOG4105QIV RNA polymerase S100141_03976 ENOG410683Z Preprotein translocase SecE subunit S100141_03977 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) S100141_03978 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) S100141_03979 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) S100141_03980 ENOG4108VZM 50s ribosomal protein L10 S100141_03981 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) S100141_03982 ENOG4107Y49 methyltransferase S100141_03983 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S100141_03984 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S100141_03985 ENOG4105XPM ribosomal protein S100141_03986 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) S100141_03987 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) S100141_03988 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) S100141_03989 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) S100141_03990 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) S100141_03991 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) S100141_03992 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) S100141_03993 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) S100141_03994 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity S100141_03995 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) S100141_03996 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) S100141_03997 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) S100141_03998 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) S100141_03999 ENOG41082SA 50s ribosomal protein l29 S100141_04000 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal S100141_04001 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) S100141_04002 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) S100141_04003 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits S100141_04004 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) S100141_04005 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) S100141_04006 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) S100141_04007 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) S100141_04008 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) S100141_04009 ENOG4105VPB 50S ribosomal protein L30 S100141_04010 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) S100141_04011 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) S100141_04012 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) S100141_04013 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) S100141_04015 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) S100141_04017 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits S100141_04018 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) S100141_04019 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S100141_04020 ENOG4108ZT0 50S ribosomal protein l17 S100141_04021 ENOG4108JJB ABC transporter S100141_04022 ENOG4108JJB ABC transporter S100141_04023 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) S100141_04024 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) S100141_04025 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) S100141_04026 ENOG4108UJD 30S ribosomal protein S9 S100141_04030 ENOG4105D1F ATP-binding protein S100141_04033 ENOG4108NMV polysaccharide deacetylase S100141_04040 ENOG4108A04 Beta-lactamase S100141_04044 ENOG4105JAB phenazine biosynthesis protein, phzf family S100141_04045 ENOG4105EHZ conserved protein UCP016719 S100141_04046 ENOG4105D17 glycoside hydrolase, family 3 domain protein S100141_04050 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate S100141_04051 ENOG4105EWC Purine nucleoside phosphorylase S100141_04058 ENOG4105EMN RNA polymerase sigma factor S100141_04060 ENOG4105C8B TIGR00159 family S100141_04061 ENOG4107U5W ybbr family S100141_04062 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) S100141_04063 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) S100141_04066 ENOG4105DVE abc transporter atp-binding protein S100141_04067 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family S100141_04068 ENOG4105WAB arsR family transcriptional regulator S100141_04069 ENOG4108RWP Major Facilitator Superfamily protein S100141_04071 ENOG4105BZ1 (ABC) transporter S100141_04072 ENOG4107ZXU DSBA oxidoreductase S100141_04075 ENOG41075D4 Aminoglycoside 6-adenylyltransferase S100141_04081 ENOG4108MRH transcriptional regulatory protein S100141_04083 ENOG4105DUM transcriptional regulator, lysR family S100141_04085 ENOG4105E5W Transporter S100141_04086 ENOG4106DDH Sporulation-specific SASP protein S100141_04089 ENOG4105C7Z Conserved Protein S100141_04090 ENOG4105FTQ Dna gyrase S100141_04091 ENOG4105C7Z Conserved Protein S100141_04092 ENOG4105DXI Major Facilitator superfamily S100141_04097 ENOG4107I77 yiaA/B two helix domain S100141_04102 ENOG410631K Membrane S100141_04103 ENOG4106AXJ AraC family transcriptional regulator S100141_04107 ENOG4107SCQ Iron-containing alcohol dehydrogenase S100141_04108 ENOG4105C8Q Methyl-accepting chemotaxis S100141_04109 ENOG4105DFW ABC transporter S100141_04112 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid S100141_04114 ENOG4108IQI permease S100141_04115 ENOG4108J5H Homocysteine s-methyltransferase S100141_04117 ENOG4105CI1 PTS System S100141_04118 ENOG4107TXC Transcriptional regulator S100141_04119 ENOG4108QY0 Membrane S100141_04123 ENOG4105CSV Glutaminase S100141_04126 ENOG4105KNA -acetyltransferase S100141_04128 ENOG4105NA0 Transcriptional regulator S100141_04130 ENOG4105DGI Alkaline phosphatase S100141_04131 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) S100141_04132 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) S100141_04133 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase S100141_04134 ENOG4105C26 Dehydrogenase S100141_04135 ENOG4105DJB Major Facilitator Superfamily S100141_04136 ENOG4105EQX glucarate dehydratase S100141_04137 ENOG41073TP transcriptional regulator S100141_04138 ENOG4105CTX dehydratase S100141_04139 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S100141_04144 ENOG4108R1P S100141_04145 ENOG4106K80 S100141_04147 ENOG41067TZ transcriptional regulator, MarR family S100141_04152 ENOG4107TXC Transcriptional regulator S100141_04157 ENOG4106UX7 integral membrane protein S100141_04159 ENOG41060AI SEC-C motif S100141_04160 ENOG4105DA5 (ABC) transporter S100141_04165 ENOG4108KSA LysR family transcriptional regulator S100141_04166 ENOG4105MDS 4-oxalocrotonate tautomerase S100141_04172 ENOG4108W0I acetyltransferase S100141_04174 ENOG4105DPN Oligoendopeptidase f S100141_04175 ENOG4107BMA Transglycosylase associated protein S100141_04177 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) S100141_04178 ENOG4105CQB FAD linked oxidase domain protein S100141_04179 ENOG4105VZJ PTS System S100141_04180 ENOG4105VCP PTS System S100141_04181 ENOG4105CK1 PTS System S100141_04182 ENOG4105F8D glycoside hydrolase family 4 S100141_04183 ENOG4108X79 transcriptional regulator S100141_04184 ENOG410901P UPF0249 protein S100141_04188 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases S100141_04189 ENOG4105H9W Short-chain dehydrogenase reductase Sdr S100141_04192 ENOG4105KHC sulfurtransferase S100141_04194 ENOG4105DEN Luciferase family S100141_04195 ENOG4105Z8B NlpC/P60 family S100141_04197 ENOG4105CIG ABC transporter S100141_04198 ENOG4108RZE Tetr family transcriptional regulator S100141_04202 ENOG4108N0M stress protein S100141_04203 ENOG4106FN3 tellurium resistance protein S100141_04204 ENOG4106FN3 tellurium resistance protein S100141_04205 ENOG4107TS3 membrane protein, TerC S100141_04208 ENOG4108TTB tellurium resistance protein S100141_04210 ENOG4107QIV Cytochrome c biogenesis protein S100141_04212 ENOG4107SWG transcriptional regulator MERR family S100141_04219 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) S100141_04220 ENOG410756H nucleotidyltransferase S100141_04222 ENOG4105C26 Dehydrogenase S100141_04223 ENOG4105CK7 Sodium proline symporter S100141_04224 ENOG4107YHD transcriptional regulator S100141_04226 ENOG4108PJD permease S100141_04227 ENOG4105I82 acetyl xylan esterase S100141_04231 ENOG4105E5Q amino acid AbC transporter S100141_04232 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein S100141_04233 ENOG4105NF4 modulator of drug activity S100141_04235 ENOG4105CS2 ec 3.2.1.21 S100141_04238 ENOG4107WDG serine threonine protein kinase S100141_04239 ENOG4105C8Q Methyl-accepting chemotaxis S100141_04240 ENOG4105C8Q Methyl-accepting chemotaxis S100141_04246 ENOG4105F38 ABC transporter, permease S100141_04248 ENOG4105CEY Amp-dependent synthetase and ligase S100141_04252 ENOG4105SX7 Transporter S100141_04254 ENOG4105W8Z 4'-phosphopantetheinyl transferase S100141_04255 ENOG4108SA1 esterase S100141_04256 ENOG41086D8 Transcriptional regulator S100141_04259 ENOG4105CJ1 ABC, transporter S100141_04265 ENOG4105CDA abc transporter atp-binding protein S100141_04266 ENOG4105DRP amino acid AbC transporter S100141_04268 ENOG4108JUB Transcriptional regulator S100141_04269 ENOG4105C8Y Acetylornithine aminotransferase S100141_04270 ENOG4108IQI permease S100141_04271 ENOG41066UZ arginase EC 3.5.3.1 S100141_04272 ENOG4106P55 Transcriptional regulator S100141_04273 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase S100141_04274 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) S100141_04275 ENOG41069ZX S100141_04276 ENOG41069ZX S100141_04284 ENOG4107EV6 Inherit from COG: YD repeat protein S100141_04288 ENOG4105C2F Histidine kinase S100141_04289 ENOG4105EQD regulatoR S100141_04290 ENOG4105DFW ABC transporter S100141_04292 ENOG4108HWW ABC transporter S100141_04293 ENOG4105DCM major facilitator superfamily S100141_04294 ENOG410645S MarR family Transcriptional regulator S100141_04295 ENOG4105C4C beta-galactosidase S100141_04296 ENOG4107T32 3-phytase (EC 3.1.3.8) S100141_04297 ENOG4105DUX Transporter S100141_04300 ENOG4105E1K spore germination protein S100141_04303 ENOG4107TXC Transcriptional regulator S100141_04305 ENOG4107WD8 ABC transporter, permease S100141_04306 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S100141_04307 ENOG4105BZU Histidine kinase S100141_04308 ENOG4105C8Q Methyl-accepting chemotaxis S100141_04309 ENOG4105C8Q Methyl-accepting chemotaxis S100141_04310 ENOG4105CFH Aspartokinase S100141_04311 ENOG4105DHS permease protein S100141_04312 ENOG4105CM4 permease protein S100141_04313 ENOG4108IPW abc transporter atp-binding protein S100141_04316 ENOG4105R8C Transcriptional regulator S100141_04318 ENOG4108DBC nitroreductase S100141_04319 ENOG41067V3 Antibiotic biosynthesis monooxygenase S100141_04320 ENOG4105YVS arsR family transcriptional regulator S100141_04322 ENOG4108JPW Aminotransferase S100141_04323 ENOG4107QTZ amino acid S100141_04324 ENOG4105C26 Dehydrogenase S100141_04325 ENOG4108RNG Permease of the drug metabolite transporter S100141_04327 ENOG4105KTB nuclear export factor GLE1 S100141_04328 ENOG4108T5E Copper resistance protein S100141_04329 ENOG4108ZYE Transcriptional regulator S100141_04331 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) S100141_04332 ENOG4108IFG nitrite reductase, (NAD(P)H) S100141_04333 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit S100141_04334 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) S100141_04335 ENOG4105DRR Transcriptional regulator, GntR family S100141_04336 ENOG4105C8P )-transporter S100141_04339 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia S100141_04343 ENOG4108IUS Transketolase S100141_04345 ENOG4105E7W lamb ycsf family protein S100141_04346 ENOG4105C5A transporter S100141_04347 ENOG4105CFM UPF0317 protein S100141_04348 ENOG4105P4J Allophanate hydrolase, subunit 1 S100141_04350 ENOG4107258 Transcriptional regulator S100141_04351 ENOG4105XJB lipolytic protein G-D-S-L family S100141_04354 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase S100141_04355 ENOG4105ETD TRANSCRIPTIONal S100141_04356 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S100141_04359 ENOG410606W general stress protein S100141_04361 ENOG4108RCF TRANSCRIPTIONal S100141_04362 ENOG4105VCH membrane S100141_04365 ENOG4105C9U ATP-dependent DNA helicase RecQ S100141_04366 ENOG4105C0X amino acid S100141_04367 ENOG4105C0X amino acid S100141_04369 ENOG4108M1A Chitin-binding protein S100141_04372 ENOG4105DQ6 Transposase S100141_04375 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) S100141_04376 ENOG4107BMA Transglycosylase associated protein S100141_04377 ENOG4108IJ0 Aspartate ammonia-lyase S100141_04378 ENOG41087PP glycosyltransferase MGT family S100141_04379 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) S100141_04380 ENOG4105EU9 S100141_04382 ENOG41082W1 Cupin 2, conserved barrel domain protein S100141_04383 ENOG4105QVS general stress protein S100141_04384 ENOG4106F5Q Membrane S100141_04385 ENOG4105CK2 sodium dicarboxylate symporter S100141_04386 ENOG4105CJ1 ABC, transporter S100141_04389 ENOG4105FDT acyl-CoA dehydrogenase S100141_04392 ENOG4105SZ6 Thioredoxin S100141_04393 ENOG4105CPF Cell wall formation (By similarity) S100141_04394 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) S100141_04396 ENOG4105C1J atp-dependent rna helicase S100141_04397 ENOG410905X membrane-flanked domain protein S100141_04398 ENOG4105CKV Membrane S100141_04400 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein S100141_04401 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) S100141_04403 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) S100141_04404 ENOG4107MMM Anti-sigma-factor antagonist S100141_04405 ENOG4105FUA antagonist S100141_04406 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase S100141_04407 ENOG4107SGM protein serine threonine phosphatase S100141_04411 ENOG41064BQ Phosphatase S100141_04413 ENOG4105ST3 Transcriptional regulator S100141_04414 ENOG4105EYF MMPL domain protein S100141_04424 ENOG4105VZ8 Transcriptional regulator S100141_04425 ENOG4105ECK Fatty Acid Desaturase S100141_04426 ENOG4105VEQ Cold shock protein S100141_04427 ENOG4105CPQ Dehydrogenase S100141_04430 ENOG4108U05 Transcriptional regulator S100141_04431 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 S100141_04434 ENOG4105KVH Transcriptional regulator S100141_04440 ENOG4107XCH Cyclase family S100141_04441 ENOG4105C85 amino acid S100141_04444 ENOG4105JVQ RNA Polymerase S100141_04445 ENOG4108P49 AntiSigma factor S100141_04446 ENOG4105EXC Acyl-transferase S100141_04447 ENOG4105C2C drug resistance transporter, Bcr CflA S100141_04449 ENOG4108NEV two component transcriptional regulator, LytTR family S100141_04452 ENOG4108Z6X (sortase) family S100141_04453 ENOG4107QNK )-transporter S100141_04454 ENOG4107QNK )-transporter S100141_04462 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) S100141_04463 ENOG4105K8N protein family UPF0079, ATPase S100141_04464 ENOG41072GX Peptidase M22 Glycoprotease S100141_04465 ENOG410801F ribosomal-protein-alanine acetyltransferase S100141_04466 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) S100141_04467 ENOG4105C5H ABC transporter S100141_04469 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) S100141_04470 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) S100141_04471 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) S100141_04473 ENOG4108TYN CAAX amino terminal protease family protein S100141_04474 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) S100141_04475 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) S100141_04481 ENOG41073R8 VanW family S100141_04484 ENOG4108RAV Conserved protein S100141_04485 ENOG4108X07 Tetr family transcriptional regulator S100141_04486 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) S100141_04488 ENOG4105K78 MarR family Transcriptional regulator S100141_04489 ENOG4108VHC Short-chain dehydrogenase reductase Sdr S100141_04490 ENOG4105EBR Carboxylesterase S100141_04492 ENOG41087YS Phage shock protein A S100141_04493 ENOG4105DQX Zinc finger domain S100141_04494 ENOG4108WV1 Pfam:DUF477 S100141_04497 ENOG4108NGU Transcriptional regulator S100141_04498 ENOG4105N14 lysine exporter protein LysE YggA S100141_04500 ENOG4105CNI cell division protein FtsW S100141_04501 ENOG4105CNI cell division protein FtsW S100141_04505 ENOG4108ZJ4 polysaccharide deacetylase S100141_04506 ENOG4105E5K Alpha-amylase S100141_04507 ENOG4105FKQ transcriptional regulator S100141_04508 ENOG4108IUK alpha amylase, catalytic S100141_04509 ENOG4107FKK extracellular solute-binding protein family 1 S100141_04510 ENOG4105D56 permease protein S100141_04511 ENOG4105EG2 ABC transporter, permease S100141_04514 ENOG4105CG3 alpha amylase, catalytic region S100141_04515 ENOG4107URF beta-phospho-glucomutase S100141_04516 ENOG4107URF beta-phospho-glucomutase S100141_04517 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) S100141_04518 ENOG4105GVJ transcriptional regulator S100141_04529 ENOG4108W3Q Transcriptional regulator S100141_04530 ENOG4107STQ Multicopper oxidase S100141_04534 ENOG4105C7R Atpase associated with various cellular activities aaa_3 S100141_04537 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) S100141_04538 ENOG4105C7N Xanthine uracil vitamin C permease S100141_04541 ENOG4108U5N UPF0316 protein S100141_04543 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) S100141_04544 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit S100141_04545 ENOG4105C83 adenylosuccinate lyase S100141_04546 ENOG4105C8V SAICAR synthetase S100141_04547 ENOG4105VR9 phosphoribosylformylglycinamidine synthase S100141_04549 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii S100141_04551 ENOG4105CXB phosphoribosylaminoimidazole synthetase S100141_04552 ENOG4108V3E phosphoribosylglycinamide formyltransferase S100141_04553 ENOG4105DC1 bifunctional purine biosynthesis protein purh S100141_04554 ENOG4105C12 Phosphoribosylglycinamide synthetase S100141_04556 ENOG4106A3M Cytochrome p-450 S100141_04562 ENOG4108R5T secreted protein S100141_04563 ENOG4105KGF protein, YerC YecD S100141_04565 ENOG4105C4R Atp-dependent dna helicase S100141_04566 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) S100141_04569 ENOG4108M21 S100141_04571 ENOG4105MUZ Protein of unknown function DUF2620 S100141_04572 ENOG4106M0N transport system permease protein S100141_04573 ENOG41080QX K07048 phosphotriesterase-related protein S100141_04574 ENOG4106PKC pyridoxal phosphate binding S100141_04575 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) S100141_04576 ENOG4108626 Racemase S100141_04577 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) S100141_04578 ENOG4105KT7 mgtC SapB transporter S100141_04579 ENOG4105CK7 Sodium proline symporter S100141_04580 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) S100141_04581 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) S100141_04582 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) S100141_04585 ENOG4105D3P Mannan endo-1,4-beta-mannosidase S100141_04586 ENOG4108IG5 Transcriptional regulator S100141_04589 ENOG4105D9U N-acetyltransferase S100141_04591 ENOG4105CBD Diacylglycerol kinase S100141_04592 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) S100141_04599 ENOG4105F5P DNA-damage-inducible protein d S100141_04601 ENOG4105DZR Type I site-specific deoxyribonuclease S100141_04607 ENOG4105DQ6 Transposase S100141_04608 ENOG4105C5Y PTS System S100141_04609 ENOG4105CS2 ec 3.2.1.21 S100141_04610 ENOG4105CID antiterminator S100141_04611 ENOG410780I phosphoprotein phosphatase activity S100141_04614 ENOG4105CDY transcriptional regulatory protein S100141_04617 ENOG4105C26 Dehydrogenase S100141_04618 ENOG4105FKZ Methyl-accepting chemotaxis S100141_04619 ENOG4105C8P )-transporter S100141_04620 ENOG4105C5H ABC transporter S100141_04621 ENOG4105C5H ABC transporter S100141_04622 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) S100141_04623 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase S100141_04624 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase S100141_04626 ENOG4105CKI cobalamin synthesis protein S100141_04627 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) S100141_04628 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) S100141_04629 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S100141_04630 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) S100141_04631 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) S100141_04632 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) S100141_04633 ENOG4106A3M Cytochrome p-450 S100141_04635 ENOG4107SWG transcriptional regulator MERR family S100141_04636 ENOG4105DXB Major Facilitator superfamily S100141_04637 ENOG4105C5H ABC transporter S100141_04638 ENOG4105FDU atp-dependent rna helicase S100141_04639 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein S100141_04642 ENOG4107QPK )-transporter S100141_04650 ENOG41082BM Transcriptional regulator, arsr family S100141_04651 ENOG410855V Acylphosphatase S100141_04652 ENOG4108RPX mosc domain containing protein S100141_04655 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) S100141_04659 ENOG4105C5Y PTS System S100141_04660 ENOG4105CG3 alpha amylase, catalytic region S100141_04661 ENOG4107414 GntR family transcriptional regulator S100141_04666 ENOG4105DQ6 Transposase S100141_04668 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase S100141_04669 ENOG4105D7W serine acetyltransferase S100141_04670 ENOG4108IAJ Nad-dependent epimerase dehydratase S100141_04673 ENOG4107TVC Glycosyl transferase, family 2 S100141_04676 ENOG4107QQG Dehydrogenase S100141_04678 ENOG4105KVH Transcriptional regulator S100141_04679 ENOG4108RCM Nitroreductase S100141_04681 ENOG4105CGH 5'-nucleotidase S100141_04682 ENOG4107RKG DJ-1/PfpI family S100141_04684 ENOG4105BZG amino acid carrier protein S100141_04685 ENOG4105KJF protein tyrosine phosphatase S100141_04687 ENOG4107U9T Pfam:Ribonuclease_BN S100141_04689 ENOG4108ISG Major Facilitator S100141_04691 ENOG4105UPD Calcium Proton S100141_04697 ENOG4105DCT glycerol dehydrogenase S100141_04699 ENOG4105D7N magnesium and cobalt transport protein CorA S100141_04701 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) S100141_04709 ENOG41079KZ Major Facilitator Superfamily S100141_04713 ENOG4105EVH UPF0753 protein S100141_04714 ENOG4108TWJ NADH dehydrogenase subunit 5 S100141_04715 ENOG4105GPN Uncharacterized conserved protein (DUF2294) S100141_04717 ENOG4107RUY (E1 component), alpha subunit S100141_04719 ENOG4107QKR Dehydrogenase S100141_04721 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family S100141_04722 ENOG4105KK4 UPF0060 membrane protein S100141_04723 ENOG4105F8D glycoside hydrolase family 4 S100141_04724 ENOG4108Q3X Transcriptional regulator S100141_04725 ENOG4105CI1 PTS System S100141_04728 ENOG4105KVH Transcriptional regulator S100141_04730 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase S100141_04731 ENOG4105E4I Glycoside hydrolase family 28 S100141_04732 ENOG4105DSG hydrolase family 43 S100141_04733 ENOG4106HBX Transcriptional Regulator AraC Family S100141_04735 ENOG4105DYS nad(p)h dehydrogenase (quinone) S100141_04740 ENOG4105JAB phenazine biosynthesis protein, phzf family S100141_04741 ENOG4107Y03 Nitroreductase S100141_04745 ENOG4105ECP epimerase S100141_04746 ENOG410691R Modulates RecA activity (By similarity) S100141_04751 ENOG4105CKK Glycosyl transferase, family 2 S100141_04753 ENOG4105EJV Membrane S100141_04754 ENOG41067AE Membrane-bound metal-dependent hydrolase S100141_04755 ENOG4105CEN a g-specific adenine glycosylase S100141_04756 ENOG4106BXE S100141_04757 ENOG4105CAN Short-chain dehydrogenase reductase Sdr S100141_04761 ENOG4105BZ1 (ABC) transporter S100141_04762 ENOG4105C3U ABC transporter S100141_04763 ENOG4108JQ7 (ABC) transporter S100141_04764 ENOG4105DEF Extracellular solute-binding protein, family 5 S100141_04765 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S100141_04766 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S100141_04767 ENOG4107NBY Membrane S100141_04768 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase S100141_04769 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S100141_04770 ENOG4105G5W regulator Fur family S100141_04771 ENOG4105TUA UPF0295 protein S100141_04791 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S100141_04821 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) S100141_04823 ENOG4105C4R Atp-dependent dna helicase S100141_04856 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) S100141_04863 ENOG4105C7H Helicase, RecD TraA family S100141_04956 ENOG4105K4H Nlp p60 protein S100141_04992 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S100141_04994 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S100141_04995 ENOG4105U6W MutT NUDIX family protein S100141_04999 ENOG4108UK2 deaminase S100141_05002 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S100141_05009 ENOG4105C0B DNA polymerase III (alpha subunit) S100141_05011 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase S100141_05016 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) S100141_05036 ENOG4105I03 Flagellin S100141_05043 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) S100141_05047 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 S100141_05049 ENOG4108UK2 deaminase S100141_05050 ENOG4105KQC Competence protein S100141_05052 ENOG4108D32 Methyltransferase S100141_05054 ENOG4108WF2 Metal Dependent Phosphohydrolase S100141_05055 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) S100141_05056 ENOG410812S Rna-binding protein S100141_05057 ENOG4105E2X shikimate dehydrogenase S100141_05058 ENOG4105CQW ribosome biogenesis GTPase YqeH S100141_05059 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase S100141_05060 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase S100141_05063 ENOG4105Z7P Acetyltransferase (GNAT) family S100141_05064 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) S100141_05065 ENOG4108JB9 formate dehydrogenase S100141_05068 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_05069 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein S100141_05071 ENOG4108IXY short-chain dehydrogenase reductase S100141_05072 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S100141_05073 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S100141_05074 ENOG4107TTQ Alpha beta hydrolase fold S100141_05075 ENOG4105M4P Tetr family transcriptional regulator S100141_05077 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_05084 ENOG4108ZRV stage ii sporulation protein p S100141_05086 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S100141_05093 ENOG41085GJ domain protein S100141_05096 ENOG4105WH1 Two component transcriptional regulator luxr family S100141_05097 ENOG4105WH1 Two component transcriptional regulator luxr family S100141_05098 ENOG4105BZU Histidine kinase S100141_05100 ENOG41087NI Sulfite exporter TauE/SafE S100141_05101 ENOG4105VFE sira family S100141_05102 ENOG4107TPS domain protein S100141_05103 ENOG4105VFE sira family S100141_05104 ENOG4105VFE sira family S100141_05105 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase S100141_05106 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase S100141_05114 ENOG4105D52 delta-aminolevulinic acid dehydratase S100141_05115 ENOG4105D52 delta-aminolevulinic acid dehydratase S100141_05116 ENOG4105DSE periplasmic solute binding protein S100141_05117 ENOG4105DIK (ABC) transporter S100141_05121 ENOG41090U3 tautomerase S100141_05122 ENOG4105C6Z Gluconate S100141_05124 ENOG41080HJ 6-phospho 3-hexuloisomerase S100141_05125 ENOG4108VA3 3-hexulose-6-phosphate synthase S100141_05126 ENOG4105KVH Transcriptional regulator S100141_05127 ENOG4105ECK Fatty Acid Desaturase S100141_05128 ENOG4108ZGX Histidine kinase S100141_05129 ENOG4108ZGX Histidine kinase S100141_05130 ENOG4108S01 response regulator S100141_05131 ENOG4105CAY ferredoxin--nadp reductase S100141_05132 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein S100141_05133 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein S100141_05134 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein S100141_05136 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S100141_05137 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S100141_05138 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S100141_05139 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S100141_05140 ENOG4105C3U ABC transporter S100141_05142 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)