locus-tag class description EQJ69_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EQJ69_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EQJ69_00015 ENOG410848D S4 domain protein YaaA EQJ69_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EQJ69_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQJ69_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQJ69_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EQJ69_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) EQJ69_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) EQJ69_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EQJ69_00095 ENOG4105BZW Glycerate kinase EQJ69_00100 ENOG4107QQ0 gntp family EQJ69_00105 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR EQJ69_00120 ENOG4105ZMH deoxynucleoside kinase EQJ69_00130 ENOG4105VRS hydrolase family 18 EQJ69_00135 ENOG4105GTG Isochorismatase EQJ69_00140 ENOG4108Z6B deaminase EQJ69_00150 ENOG4105C6E dna polymerase iii EQJ69_00155 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EQJ69_00160 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EQJ69_00170 ENOG41067KS pro-sigma K processing EQJ69_00210 ENOG4105CDW Resistance protein EQJ69_00215 ENOG4105CXN decarboxylase EQJ69_00220 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EQJ69_00225 ENOG4105X0R protein from nitrogen regulatory protein P-II EQJ69_00230 ENOG4105XVJ Protein of unknown function (DUF327) EQJ69_00235 ENOG4105FA2 dna polymerase iii EQJ69_00240 ENOG4105MA4 psp1 domain protein EQJ69_00245 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) EQJ69_00250 ENOG41060K3 Methyltransferase EQJ69_00255 ENOG4105VC4 domain protein EQJ69_00260 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EQJ69_00265 ENOG4105KRN Transcriptional regulator, abrb family EQJ69_00270 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EQJ69_00275 ENOG4105F8V Hydrolase, tatD family EQJ69_00280 ENOG41069ER domain protein EQJ69_00290 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EQJ69_00295 ENOG4105XFA sporulation peptidase YabG EQJ69_00300 ENOG4105W42 Veg protein EQJ69_00305 ENOG4105XEW small acid-soluble spore protein EQJ69_00310 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EQJ69_00315 ENOG4105DFT pur operon repressor EQJ69_00320 ENOG4105KME endoribonuclease L-psp EQJ69_00325 ENOG4105K4W Could be involved in septation (By similarity) EQJ69_00330 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EQJ69_00335 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EQJ69_00340 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EQJ69_00355 ENOG4108JA2 transcriptioN-repair coupling factor EQJ69_00360 ENOG4108M14 stage v sporulation protein t EQJ69_00370 ENOG4108IY2 MazG family EQJ69_00375 ENOG41082I2 s4 domain protein EQJ69_00380 ENOG4105VYY sporulation protein yabp EQJ69_00395 ENOG41060GV RNA binding s1 domain protein EQJ69_00425 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EQJ69_00430 ENOG4108UGV hypoxanthine phosphoribosyltransferase EQJ69_00435 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EQJ69_00440 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) EQJ69_00445 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EQJ69_00450 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase EQJ69_00455 ENOG4105C6T cysteine synthase EQJ69_00465 ENOG4105CRQ synthase (Component I) EQJ69_00470 ENOG4105DDQ anthranilate synthase EQJ69_00475 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 EQJ69_00480 ENOG4105EEI dihydropteroate synthase EQJ69_00485 ENOG4105KRF dihydroneopterin aldolase EQJ69_00490 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EQJ69_00500 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EQJ69_00505 ENOG4105CRK lysyL-tRNA synthetase EQJ69_00590 ENOG4108Z0C Uvrb UvrC protein EQJ69_00595 ENOG41066A3 ATP guanido phosphotransferase EQJ69_00605 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EQJ69_00610 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) EQJ69_00615 ENOG4105CTP PilT protein domain protein EQJ69_00620 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EQJ69_00625 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EQJ69_00630 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EQJ69_00635 ENOG4105D7W serine acetyltransferase EQJ69_00640 ENOG4105C8N cysteinyl-tRNA synthetase EQJ69_00645 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) EQJ69_00650 ENOG4105C2N RNA methyltransferase TrmH family group 3 EQJ69_00655 ENOG4105M0M Tetracycline resistance protein EQJ69_00660 ENOG4105QIV RNA polymerase EQJ69_00670 ENOG410683Z Preprotein translocase SecE subunit EQJ69_00675 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EQJ69_00680 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EQJ69_00685 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) EQJ69_00690 ENOG4108VZM 50s ribosomal protein L10 EQJ69_00695 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EQJ69_00700 ENOG4107Y49 methyltransferase EQJ69_00705 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQJ69_00710 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQJ69_00715 ENOG4105XPM ribosomal protein EQJ69_00720 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EQJ69_00725 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EQJ69_00730 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EQJ69_00735 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EQJ69_00740 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EQJ69_00745 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EQJ69_00750 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EQJ69_00755 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EQJ69_00760 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EQJ69_00765 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EQJ69_00770 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EQJ69_00775 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EQJ69_00780 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EQJ69_00785 ENOG41082SA 50s ribosomal protein l29 EQJ69_00790 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EQJ69_00795 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EQJ69_00800 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EQJ69_00805 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EQJ69_00810 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EQJ69_00815 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EQJ69_00820 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EQJ69_00825 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EQJ69_00830 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EQJ69_00835 ENOG4105VPB 50S ribosomal protein L30 EQJ69_00840 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EQJ69_00845 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EQJ69_00850 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EQJ69_00855 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EQJ69_00865 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EQJ69_00875 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EQJ69_00880 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EQJ69_00885 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQJ69_00890 ENOG4108ZT0 50S ribosomal protein l17 EQJ69_00895 ENOG4108JJB ABC transporter EQJ69_00900 ENOG4108JJB ABC transporter EQJ69_00905 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EQJ69_00910 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EQJ69_00915 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EQJ69_00920 ENOG4108UJD 30S ribosomal protein S9 EQJ69_00940 ENOG4105D1F ATP-binding protein EQJ69_00955 ENOG4108NMV polysaccharide deacetylase EQJ69_00985 ENOG4108A04 Beta-lactamase EQJ69_01005 ENOG4105JAB phenazine biosynthesis protein, phzf family EQJ69_01010 ENOG4105EHZ conserved protein UCP016719 EQJ69_01015 ENOG4105D17 glycoside hydrolase, family 3 domain protein EQJ69_01035 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EQJ69_01040 ENOG4105EWC Purine nucleoside phosphorylase EQJ69_01075 ENOG4105EMN RNA polymerase sigma factor EQJ69_01085 ENOG4105C8B TIGR00159 family EQJ69_01090 ENOG4107U5W ybbr family EQJ69_01095 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EQJ69_01100 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EQJ69_01120 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EQJ69_01125 ENOG4105WAB arsR family transcriptional regulator EQJ69_01130 ENOG4108RWP Major Facilitator Superfamily protein EQJ69_01140 ENOG4105BZ1 (ABC) transporter EQJ69_01145 ENOG4107ZXU DSBA oxidoreductase EQJ69_01160 ENOG41075D4 Aminoglycoside 6-adenylyltransferase EQJ69_01190 ENOG4108MRH transcriptional regulatory protein EQJ69_01200 ENOG4105DUM transcriptional regulator, lysR family EQJ69_01205 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EQJ69_01210 ENOG4105E5W Transporter EQJ69_01215 ENOG4106DDH Sporulation-specific SASP protein EQJ69_01230 ENOG4105C7Z Conserved Protein EQJ69_01240 ENOG4105C22 threonyL-tRNA synthetase EQJ69_01255 ENOG4105E18 UPF0276 protein EQJ69_01270 ENOG4105C37 (CBS) domain EQJ69_01275 ENOG4105C7Z Conserved Protein EQJ69_01285 ENOG4105DXI Major Facilitator superfamily EQJ69_01310 ENOG4107I77 yiaA/B two helix domain EQJ69_01335 ENOG410631K Membrane EQJ69_01360 ENOG4107SCQ Iron-containing alcohol dehydrogenase EQJ69_01365 ENOG4105C8Q Methyl-accepting chemotaxis EQJ69_01370 ENOG4105DFW ABC transporter EQJ69_01385 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid EQJ69_01395 ENOG4108IQI permease EQJ69_01400 ENOG4108J5H Homocysteine s-methyltransferase EQJ69_01410 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane EQJ69_01415 ENOG4107TXC Transcriptional regulator EQJ69_01420 ENOG4108QY0 Membrane EQJ69_01445 ENOG4105CSV Glutaminase EQJ69_01460 ENOG4105KNA -acetyltransferase EQJ69_01470 ENOG4105NA0 Transcriptional regulator EQJ69_01480 ENOG4105DGI Alkaline phosphatase EQJ69_01485 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EQJ69_01490 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EQJ69_01495 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase EQJ69_01500 ENOG4105C26 Dehydrogenase EQJ69_01505 ENOG4105DJB Major Facilitator Superfamily EQJ69_01510 ENOG4105EQX glucarate dehydratase EQJ69_01515 ENOG41073TP transcriptional regulator EQJ69_01520 ENOG4105CTX dehydratase EQJ69_01525 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQJ69_01550 ENOG4108R1P EQJ69_01555 ENOG4106K80 EQJ69_01565 ENOG41067TZ transcriptional regulator, MarR family EQJ69_01590 ENOG4107TXC Transcriptional regulator EQJ69_01615 ENOG4106UX7 integral membrane protein EQJ69_01625 ENOG41060AI SEC-C motif EQJ69_01630 ENOG4105DA5 (ABC) transporter EQJ69_01655 ENOG4108KSA LysR family transcriptional regulator EQJ69_01660 ENOG4105MDS 4-oxalocrotonate tautomerase EQJ69_01690 ENOG4108W0I acetyltransferase EQJ69_01700 ENOG4105DPN Oligoendopeptidase f EQJ69_01705 ENOG4107BMA Transglycosylase associated protein EQJ69_01715 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EQJ69_01720 ENOG4105CQB FAD linked oxidase domain protein EQJ69_01725 ENOG4105VZJ PTS System EQJ69_01730 ENOG4105VCP PTS System EQJ69_01735 ENOG4105CK1 PTS System EQJ69_01740 ENOG4105F8D glycoside hydrolase family 4 EQJ69_01745 ENOG4108X79 transcriptional regulator EQJ69_01750 ENOG410901P UPF0249 protein EQJ69_01765 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases EQJ69_01770 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQJ69_01785 ENOG4105KHC sulfurtransferase EQJ69_01795 ENOG4105DEN Luciferase family EQJ69_01800 ENOG4105Z8B NlpC/P60 family EQJ69_01815 ENOG4108RZE Tetr family transcriptional regulator EQJ69_01835 ENOG4108N0M stress protein EQJ69_01840 ENOG4106FN3 tellurium resistance protein EQJ69_01845 ENOG4106FN3 tellurium resistance protein EQJ69_01850 ENOG4107TS3 membrane protein, TerC EQJ69_01865 ENOG4108TTB tellurium resistance protein EQJ69_01875 ENOG4107QIV Cytochrome c biogenesis protein EQJ69_01885 ENOG4107SWG transcriptional regulator MERR family EQJ69_01920 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EQJ69_01925 ENOG410756H nucleotidyltransferase EQJ69_01935 ENOG4105C26 Dehydrogenase EQJ69_01940 ENOG4105CK7 Sodium proline symporter EQJ69_01945 ENOG4107YHD transcriptional regulator EQJ69_01955 ENOG4108PJD permease EQJ69_01960 ENOG4105I82 acetyl xylan esterase EQJ69_01980 ENOG4105E5Q amino acid AbC transporter EQJ69_01985 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein EQJ69_01990 ENOG4105NF4 modulator of drug activity EQJ69_02000 ENOG4105CS2 ec 3.2.1.21 EQJ69_02020 ENOG4107WDG serine threonine protein kinase EQJ69_02055 ENOG4105F38 ABC transporter, permease EQJ69_02060 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component EQJ69_02065 ENOG4105CEY Amp-dependent synthetase and ligase EQJ69_02085 ENOG4105SX7 Transporter EQJ69_02095 ENOG4105W8Z 4'-phosphopantetheinyl transferase EQJ69_02120 ENOG4105CJ1 ABC, transporter EQJ69_02145 ENOG4105CDA abc transporter atp-binding protein EQJ69_02150 ENOG4105DRP amino acid AbC transporter EQJ69_02160 ENOG4108JUB Transcriptional regulator EQJ69_02165 ENOG4105C8Y Acetylornithine aminotransferase EQJ69_02170 ENOG4108IQI permease EQJ69_02175 ENOG41066UZ arginase EC 3.5.3.1 EQJ69_02180 ENOG4106P55 Transcriptional regulator EQJ69_02185 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase EQJ69_02190 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EQJ69_02195 ENOG41069ZX EQJ69_02200 ENOG41069ZX EQJ69_02240 ENOG4107EV6 Inherit from COG: YD repeat protein EQJ69_02260 ENOG4105C2F Histidine kinase EQJ69_02265 ENOG4105EQD regulatoR EQJ69_02270 ENOG4105DFW ABC transporter EQJ69_02280 ENOG4108HWW ABC transporter EQJ69_02285 ENOG4105DCM major facilitator superfamily EQJ69_02290 ENOG410645S MarR family Transcriptional regulator EQJ69_02295 ENOG4105C4C beta-galactosidase EQJ69_02300 ENOG4107T32 3-phytase (EC 3.1.3.8) EQJ69_02305 ENOG4105DUX Transporter EQJ69_02320 ENOG4105E1K spore germination protein EQJ69_02335 ENOG4107TXC Transcriptional regulator EQJ69_02345 ENOG4107WD8 ABC transporter, permease EQJ69_02350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQJ69_02355 ENOG4105BZU Histidine kinase EQJ69_02360 ENOG4105C8Q Methyl-accepting chemotaxis EQJ69_02365 ENOG4105CFH Aspartokinase EQJ69_02370 ENOG4105DHS permease protein EQJ69_02375 ENOG4105CM4 permease protein EQJ69_02380 ENOG4108IPW abc transporter atp-binding protein EQJ69_02395 ENOG4105R8C Transcriptional regulator EQJ69_02405 ENOG4108DBC nitroreductase EQJ69_02410 ENOG41067V3 Antibiotic biosynthesis monooxygenase EQJ69_02415 ENOG4105YVS arsR family transcriptional regulator EQJ69_02425 ENOG4108JPW Aminotransferase EQJ69_02430 ENOG4107QTZ amino acid EQJ69_02435 ENOG4105C26 Dehydrogenase EQJ69_02440 ENOG4108RNG Permease of the drug metabolite transporter EQJ69_02450 ENOG4105KTB nuclear export factor GLE1 EQJ69_02455 ENOG4108T5E Copper resistance protein EQJ69_02460 ENOG4108ZYE Transcriptional regulator EQJ69_02470 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EQJ69_02475 ENOG4108IFG nitrite reductase, (NAD(P)H) EQJ69_02480 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit EQJ69_02485 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EQJ69_02490 ENOG4105DRR Transcriptional regulator, GntR family EQJ69_02495 ENOG4105C8P )-transporter EQJ69_02520 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia EQJ69_02540 ENOG4108IUS Transketolase EQJ69_02550 ENOG4105E7W lamb ycsf family protein EQJ69_02555 ENOG4105C5A transporter EQJ69_02560 ENOG4105CFM UPF0317 protein EQJ69_02565 ENOG4105P4J Allophanate hydrolase, subunit 1 EQJ69_02575 ENOG4107258 Transcriptional regulator EQJ69_02580 ENOG4105XJB lipolytic protein G-D-S-L family EQJ69_02595 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase EQJ69_02600 ENOG4105ETD TRANSCRIPTIONal EQJ69_02605 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EQJ69_02620 ENOG410606W general stress protein EQJ69_02630 ENOG4108RCF TRANSCRIPTIONal EQJ69_02635 ENOG4105VCH membrane EQJ69_02650 ENOG4105C9U ATP-dependent DNA helicase RecQ EQJ69_02655 ENOG4105C0X amino acid EQJ69_02665 ENOG4108M1A Chitin-binding protein EQJ69_02680 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EQJ69_02685 ENOG4107BMA Transglycosylase associated protein EQJ69_02690 ENOG4108IJ0 Aspartate ammonia-lyase EQJ69_02700 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) EQJ69_02705 ENOG4105EU9 EQJ69_02715 ENOG41082W1 Cupin 2, conserved barrel domain protein EQJ69_02720 ENOG4105QVS general stress protein EQJ69_02725 ENOG4106F5Q Membrane EQJ69_02730 ENOG4105CK2 sodium dicarboxylate symporter EQJ69_02735 ENOG4105CJ1 ABC, transporter EQJ69_02750 ENOG4105FDT acyl-CoA dehydrogenase EQJ69_02765 ENOG4105SZ6 Thioredoxin EQJ69_02770 ENOG4105CPF Cell wall formation (By similarity) EQJ69_02775 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EQJ69_02785 ENOG4105C1J atp-dependent rna helicase EQJ69_02790 ENOG410905X membrane-flanked domain protein EQJ69_02795 ENOG4105CKV Membrane EQJ69_02805 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein EQJ69_02810 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EQJ69_02820 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EQJ69_02825 ENOG4107MMM Anti-sigma-factor antagonist EQJ69_02830 ENOG4105FUA antagonist EQJ69_02835 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase EQJ69_02840 ENOG4107SGM protein serine threonine phosphatase EQJ69_02860 ENOG41064BQ Phosphatase EQJ69_02870 ENOG4105ST3 Transcriptional regulator EQJ69_02875 ENOG4105EYF MMPL domain protein EQJ69_02935 ENOG4105VZ8 Transcriptional regulator EQJ69_02940 ENOG4105ECK Fatty Acid Desaturase EQJ69_02945 ENOG4105VEQ Cold shock protein EQJ69_02950 ENOG4105CPQ Dehydrogenase EQJ69_02965 ENOG4108U05 Transcriptional regulator EQJ69_02970 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 EQJ69_02985 ENOG4105KVH Transcriptional regulator EQJ69_02995 ENOG4108VP3 Lysine exporter protein (LysE YggA) EQJ69_03015 ENOG4107XCH Cyclase family EQJ69_03020 ENOG4105C85 amino acid EQJ69_03035 ENOG4105JVQ RNA Polymerase EQJ69_03040 ENOG4108P49 AntiSigma factor EQJ69_03045 ENOG4105EXC Acyl-transferase EQJ69_03050 ENOG4105C2C drug resistance transporter, Bcr CflA EQJ69_03060 ENOG4108NEV two component transcriptional regulator, LytTR family EQJ69_03070 ENOG4108Z6X (sortase) family EQJ69_03080 ENOG4107QNK )-transporter EQJ69_03120 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EQJ69_03125 ENOG4105K8N protein family UPF0079, ATPase EQJ69_03130 ENOG41072GX Peptidase M22 Glycoprotease EQJ69_03135 ENOG410801F ribosomal-protein-alanine acetyltransferase EQJ69_03140 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EQJ69_03145 ENOG4105C5H ABC transporter EQJ69_03155 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) EQJ69_03160 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EQJ69_03165 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EQJ69_03175 ENOG4108TYN CAAX amino terminal protease family protein EQJ69_03180 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EQJ69_03185 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EQJ69_03205 ENOG41067QW Transcriptional regulator EQJ69_03210 ENOG41067QW Transcriptional regulator EQJ69_03350 ENOG4105IG6 Phage terminase, large subunit EQJ69_03355 ENOG4108MDF Phage Portal Protein EQJ69_03360 ENOG4106CGH Phage Mu protein F like protein EQJ69_03390 ENOG41060SN EQJ69_03405 ENOG4105PQS phage protein EQJ69_03410 ENOG4105FR7 XkdM protein, phage-like element PBSX EQJ69_03420 ENOG4105MTC XkdN-like protein EQJ69_03430 ENOG4108FKH Transglycosylase SLT domain EQJ69_03430 ENOG4108FKH Transglycosylase SLT domain EQJ69_03435 ENOG4108WZM domain protein EQJ69_03440 ENOG4105X7F EQJ69_03450 ENOG4105MFU Protein of unknown function (DUF2634) EQJ69_03455 ENOG41066EA baseplate J family protein EQJ69_03460 ENOG410906S phage-like element pbsx protein xkdt EQJ69_03520 ENOG4108J9Q DNA ligase EQJ69_03595 ENOG41073R8 VanW family EQJ69_03610 ENOG4108RAV Conserved protein EQJ69_03620 ENOG4108X07 Tetr family transcriptional regulator EQJ69_03625 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EQJ69_03635 ENOG4105K78 MarR family Transcriptional regulator EQJ69_03640 ENOG4108VHC Short-chain dehydrogenase reductase Sdr EQJ69_03645 ENOG4105EBR Carboxylesterase EQJ69_03655 ENOG41087YS Phage shock protein A EQJ69_03660 ENOG4105DQX Zinc finger domain EQJ69_03665 ENOG4108WV1 Pfam:DUF477 EQJ69_03680 ENOG4108NGU Transcriptional regulator EQJ69_03685 ENOG4105N14 lysine exporter protein LysE YggA EQJ69_03695 ENOG4105CNI cell division protein FtsW EQJ69_03700 ENOG4105CNI cell division protein FtsW EQJ69_03725 ENOG4108ZJ4 polysaccharide deacetylase EQJ69_03730 ENOG4105E5K Alpha-amylase EQJ69_03735 ENOG4105FKQ transcriptional regulator EQJ69_03740 ENOG4108IUK alpha amylase, catalytic EQJ69_03745 ENOG4107FKK extracellular solute-binding protein family 1 EQJ69_03750 ENOG4105D56 permease protein EQJ69_03755 ENOG4105EG2 ABC transporter, permease EQJ69_03770 ENOG4105CG3 alpha amylase, catalytic region EQJ69_03775 ENOG4107URF beta-phospho-glucomutase EQJ69_03780 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EQJ69_03785 ENOG4105GVJ transcriptional regulator EQJ69_03840 ENOG4108W3Q Transcriptional regulator EQJ69_03845 ENOG4107STQ Multicopper oxidase EQJ69_03865 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EQJ69_03880 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EQJ69_03890 ENOG4105C7N Xanthine uracil vitamin C permease EQJ69_03905 ENOG4108U5N UPF0316 protein EQJ69_03915 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EQJ69_03920 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EQJ69_03925 ENOG4105C83 adenylosuccinate lyase EQJ69_03930 ENOG4105C8V SAICAR synthetase EQJ69_03935 ENOG4105VR9 phosphoribosylformylglycinamidine synthase EQJ69_03945 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EQJ69_03955 ENOG4105CXB phosphoribosylaminoimidazole synthetase EQJ69_03960 ENOG4108V3E phosphoribosylglycinamide formyltransferase EQJ69_03965 ENOG4105DC1 bifunctional purine biosynthesis protein purh EQJ69_03970 ENOG4105C12 Phosphoribosylglycinamide synthetase EQJ69_03980 ENOG4106A3M Cytochrome p-450 EQJ69_04005 ENOG4108R5T secreted protein EQJ69_04010 ENOG4105KGF protein, YerC YecD EQJ69_04020 ENOG4105C4R Atp-dependent dna helicase EQJ69_04025 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EQJ69_04035 ENOG4108M21 EQJ69_04045 ENOG4105MUZ Protein of unknown function DUF2620 EQJ69_04055 ENOG41080QX K07048 phosphotriesterase-related protein EQJ69_04060 ENOG4106PKC pyridoxal phosphate binding EQJ69_04065 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EQJ69_04070 ENOG4108626 Racemase EQJ69_04075 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EQJ69_04080 ENOG4105KT7 mgtC SapB transporter EQJ69_04085 ENOG4105CK7 Sodium proline symporter EQJ69_04090 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EQJ69_04095 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EQJ69_04100 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EQJ69_04115 ENOG4105D3P Mannan endo-1,4-beta-mannosidase EQJ69_04120 ENOG4108IG5 Transcriptional regulator EQJ69_04135 ENOG4105D9U N-acetyltransferase EQJ69_04140 ENOG4105DU0 nucleoside hydrolase EQJ69_04145 ENOG4105CBD Diacylglycerol kinase EQJ69_04150 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EQJ69_04185 ENOG4105DZR Type I site-specific deoxyribonuclease EQJ69_04215 ENOG4105C5Y PTS System EQJ69_04220 ENOG4105CS2 ec 3.2.1.21 EQJ69_04225 ENOG4105CID antiterminator EQJ69_04230 ENOG410780I phosphoprotein phosphatase activity EQJ69_04245 ENOG4105CDY transcriptional regulatory protein EQJ69_04260 ENOG4105C26 Dehydrogenase EQJ69_04265 ENOG4105FKZ Methyl-accepting chemotaxis EQJ69_04270 ENOG4105C8P )-transporter EQJ69_04275 ENOG4105C5H ABC transporter EQJ69_04285 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) EQJ69_04290 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase EQJ69_04300 ENOG4105CKI cobalamin synthesis protein EQJ69_04305 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) EQJ69_04310 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EQJ69_04315 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EQJ69_04320 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EQJ69_04325 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EQJ69_04330 ENOG4106A3M Cytochrome p-450 EQJ69_04340 ENOG4107SWG transcriptional regulator MERR family EQJ69_04345 ENOG4105DXB Major Facilitator superfamily EQJ69_04350 ENOG4105C5H ABC transporter EQJ69_04355 ENOG4105FDU atp-dependent rna helicase EQJ69_04360 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EQJ69_04375 ENOG4107QPK )-transporter EQJ69_04410 ENOG41082BM Transcriptional regulator, arsr family EQJ69_04415 ENOG410855V Acylphosphatase EQJ69_04420 ENOG4108RPX mosc domain containing protein EQJ69_04430 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) EQJ69_04450 ENOG4105C5Y PTS System EQJ69_04455 ENOG4105CG3 alpha amylase, catalytic region EQJ69_04460 ENOG4107414 GntR family transcriptional regulator EQJ69_04485 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EQJ69_04490 ENOG4105D7W serine acetyltransferase EQJ69_04495 ENOG4108IAJ Nad-dependent epimerase dehydratase EQJ69_04510 ENOG4107TVC Glycosyl transferase, family 2 EQJ69_04525 ENOG4107QQG Dehydrogenase EQJ69_04535 ENOG4105KVH Transcriptional regulator EQJ69_04540 ENOG4108RCM Nitroreductase EQJ69_04545 ENOG4105CGH 5'-nucleotidase EQJ69_04550 ENOG4107RKG DJ-1/PfpI family EQJ69_04560 ENOG4105BZG amino acid carrier protein EQJ69_04565 ENOG4105KJF protein tyrosine phosphatase EQJ69_04575 ENOG4107U9T Pfam:Ribonuclease_BN EQJ69_04580 ENOG4108ISG Major Facilitator EQJ69_04590 ENOG4105UPD Calcium Proton EQJ69_04615 ENOG4105DCT glycerol dehydrogenase EQJ69_04625 ENOG4105D7N magnesium and cobalt transport protein CorA EQJ69_04635 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EQJ69_04675 ENOG41079KZ Major Facilitator Superfamily EQJ69_04695 ENOG4105EVH UPF0753 protein EQJ69_04700 ENOG4108TWJ NADH dehydrogenase subunit 5 EQJ69_04705 ENOG4105GPN Uncharacterized conserved protein (DUF2294) EQJ69_04715 ENOG4107RUY (E1 component), alpha subunit EQJ69_04725 ENOG4107QKR Dehydrogenase EQJ69_04735 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EQJ69_04740 ENOG4105KK4 UPF0060 membrane protein EQJ69_04745 ENOG4105F8D glycoside hydrolase family 4 EQJ69_04750 ENOG4108Q3X Transcriptional regulator EQJ69_04755 ENOG4105CI1 PTS System EQJ69_04770 ENOG4105KVH Transcriptional regulator EQJ69_04780 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EQJ69_04785 ENOG4105E4I Glycoside hydrolase family 28 EQJ69_04790 ENOG4105DSG hydrolase family 43 EQJ69_04795 ENOG4106HBX Transcriptional Regulator AraC Family EQJ69_04805 ENOG4105DYS nad(p)h dehydrogenase (quinone) EQJ69_04825 ENOG4105JAB phenazine biosynthesis protein, phzf family EQJ69_04830 ENOG4107Y03 Nitroreductase EQJ69_04850 ENOG4105ECP epimerase EQJ69_04855 ENOG410691R Modulates RecA activity (By similarity) EQJ69_04885 ENOG4105CKK Glycosyl transferase, family 2 EQJ69_04895 ENOG4105EJV Membrane EQJ69_04900 ENOG41067AE Membrane-bound metal-dependent hydrolase EQJ69_04905 ENOG4105CEN a g-specific adenine glycosylase EQJ69_04910 ENOG4106BXE EQJ69_04915 ENOG4105CAN Short-chain dehydrogenase reductase Sdr EQJ69_04935 ENOG4105BZ1 (ABC) transporter EQJ69_04940 ENOG4105C3U ABC transporter EQJ69_04945 ENOG4108JQ7 (ABC) transporter EQJ69_04950 ENOG4105DEF Extracellular solute-binding protein, family 5 EQJ69_04955 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQJ69_04960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQJ69_04965 ENOG4107NBY Membrane EQJ69_04970 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EQJ69_04975 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQJ69_04980 ENOG4105G5W regulator Fur family EQJ69_04985 ENOG4105TUA UPF0295 protein EQJ69_05135 ENOG4107EV6 Inherit from COG: YD repeat protein EQJ69_05150 ENOG4107EV6 Inherit from COG: YD repeat protein EQJ69_05160 ENOG4105C22 threonyL-tRNA synthetase EQJ69_05170 ENOG4105FF2 Type I DHQase EQJ69_05175 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EQJ69_05180 ENOG4105D7T ABC transporter EQJ69_05185 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein EQJ69_05190 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EQJ69_05195 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EQJ69_05200 ENOG4107D63 EQJ69_05205 ENOG4105VZ8 Transcriptional regulator EQJ69_05215 ENOG4105DA5 (ABC) transporter EQJ69_05235 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EQJ69_05250 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EQJ69_05260 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EQJ69_05280 ENOG4105CYN Serine protein kinase EQJ69_05285 ENOG4106AKX UPF0229 protein EQJ69_05295 ENOG4105CW7 secretion protein, HlyD family EQJ69_05300 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQJ69_05305 ENOG4105CS1 NAD(P)H quinone oxidoreductase EQJ69_05320 ENOG4105CZV ABC transporter EQJ69_05325 ENOG4105CZV ABC transporter EQJ69_05330 ENOG4105CJ1 ABC, transporter EQJ69_05335 ENOG4108TU7 Inherit from COG: (ABC) transporter EQJ69_05340 ENOG4105VEQ Cold shock protein EQJ69_05345 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EQJ69_05350 ENOG4108UMI ABC transporter, permease EQJ69_05360 ENOG4107R6U sodium dicarboxylate symporter EQJ69_05390 ENOG4105BZU Histidine kinase EQJ69_05405 ENOG4108YBP pseudouridine synthase EQJ69_05415 ENOG41080XP Cbs domain EQJ69_05420 ENOG4107YBY Hydrolase EQJ69_05425 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EQJ69_05430 ENOG4105C5H ABC transporter EQJ69_05440 ENOG4105TMB Formate nitrite transporter EQJ69_05445 ENOG4105RK9 auxin efflux carrier EQJ69_05450 ENOG4105CB2 alcohol dehydrogenase EQJ69_05455 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EQJ69_05465 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EQJ69_05470 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EQJ69_05490 ENOG4105BZU Histidine kinase EQJ69_05495 ENOG4105WH1 Two component transcriptional regulator luxr family EQJ69_05515 ENOG4105KPV Transcriptional regulator EQJ69_05520 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EQJ69_05525 ENOG4105ED1 spovr family EQJ69_05540 ENOG4105BZN citrate synthase EQJ69_05550 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EQJ69_05555 ENOG4105C8J )-transporter EQJ69_05565 ENOG41086D8 Transcriptional regulator EQJ69_05570 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EQJ69_05585 ENOG4105J37 EQJ69_05590 ENOG4108AEY RNA polymerase sigma factor EQJ69_05595 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein EQJ69_05605 ENOG4105F6E Acyl-transferase EQJ69_05610 ENOG4105KAF membrAne EQJ69_05620 ENOG4105U5Y Transcriptional regulator EQJ69_05625 ENOG4105C37 (CBS) domain EQJ69_05635 ENOG4105C37 (CBS) domain EQJ69_05665 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EQJ69_05675 ENOG4105D64 Mechanosensitive ion channel EQJ69_05680 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EQJ69_05690 ENOG4107VMI polysaccharide deacetylase EQJ69_05695 ENOG4105F0I Aminotransferase EQJ69_05705 ENOG4108N2V aldose 1-epimerase EQJ69_05735 ENOG4105BZ1 (ABC) transporter EQJ69_05740 ENOG4105BZ1 (ABC) transporter EQJ69_05775 ENOG410839P EQJ69_05785 ENOG4106MP8 UPF0754 membrane protein EQJ69_05790 ENOG4105WZB UPF0342 protein EQJ69_05805 ENOG4105D4P Coproporphyrinogen iii oxidase EQJ69_05810 ENOG4107S91 Sodium hydrogen exchanger EQJ69_05815 ENOG4105NCW Trka-c domain protein EQJ69_05825 ENOG4105CGU Enoyl-CoA hydratase EQJ69_05845 ENOG4108IUX (ABC) transporter EQJ69_05850 ENOG4105RHA ABC transporter, permease EQJ69_05855 ENOG4107VRP DNA repair exonuclease EQJ69_05860 ENOG4106D4I domain protein EQJ69_05865 ENOG4105EQI Metal Dependent Phosphohydrolase EQJ69_05875 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EQJ69_05920 ENOG4105NBU tryptophan transport protein EQJ69_05925 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EQJ69_05930 ENOG4105K59 histidine triad (HIT) protein EQJ69_05960 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation EQJ69_05965 ENOG4105BZ4 penicillin-binding protein EQJ69_05970 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EQJ69_05975 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EQJ69_05980 ENOG4105C1Q protoporphyrinogen oxidase EQJ69_05990 ENOG4105ECB domain protein EQJ69_06000 ENOG4105DER m42 family EQJ69_06015 ENOG4106AXD EQJ69_06020 ENOG4108RQ5 Beta-lactamase domain-containing protein EQJ69_06025 ENOG4105DF9 Lipoate-protein, ligase EQJ69_06030 ENOG4105CEY Amp-dependent synthetase and ligase EQJ69_06040 ENOG4108JCI Transcriptional regulator EQJ69_06055 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 EQJ69_06060 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQJ69_06065 ENOG4108UZ3 Transporter EQJ69_06070 ENOG4108HUF Transporter EQJ69_06075 ENOG4105DQ5 transport system permease protein EQJ69_06080 ENOG4108U1V ABC transporter, permease EQJ69_06085 ENOG4107TB6 phosphoglycerate mutase EQJ69_06090 ENOG4106YBV Methyl-accepting chemotaxis EQJ69_06110 ENOG4105XVF Competence transcription factor EQJ69_06115 ENOG41060YP EQJ69_06130 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin EQJ69_06140 ENOG4105G9B Transcriptional regulator EQJ69_06150 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) EQJ69_06160 ENOG4105S0E allantoin catabolism protein EQJ69_06165 ENOG4105DG4 malate L-lactate dehydrogenase EQJ69_06170 ENOG4105DG4 malate L-lactate dehydrogenase EQJ69_06175 ENOG4107R1Q Membrane protein FdrA EQJ69_06180 ENOG4107REC cytoplasmic protein EQJ69_06190 ENOG4105C5B carbamate kinase EQJ69_06195 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) EQJ69_06205 ENOG410780I phosphoprotein phosphatase activity EQJ69_06235 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component EQJ69_06240 ENOG4105I1K ABC transporter EQJ69_06250 ENOG4108KK1 membrane protein AbrB duplication EQJ69_06265 ENOG4105WEF catalase EQJ69_06270 ENOG4105CEY Amp-dependent synthetase and ligase EQJ69_06275 ENOG4106K7D Major facilitator family transporter EQJ69_06285 ENOG4105BZU Histidine kinase EQJ69_06290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQJ69_06300 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EQJ69_06305 ENOG4105E0C molybdate abc transporter EQJ69_06315 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EQJ69_06325 ENOG4105EYH Exonuclease EQJ69_06360 ENOG410751J EQJ69_06380 ENOG4105ERH Fumarylacetoacetate hydrolase EQJ69_06400 ENOG4105CAQ asparagine synthetase EQJ69_06410 ENOG4108YZA Nitrogen regulatory protein pii EQJ69_06415 ENOG4105UQX Mate efflux family protein EQJ69_06420 ENOG4106HBX Transcriptional Regulator AraC Family EQJ69_06430 ENOG4105ETE Transcriptional regulator (LacI family EQJ69_06435 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EQJ69_06440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EQJ69_06450 ENOG4105DY8 decarboxylase EQJ69_06475 ENOG4105MA6 gCN5-related N-acetyltransferase EQJ69_06480 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQJ69_06485 ENOG4105D29 Helix-turn-helix type 11 domain protein EQJ69_06500 ENOG4108VPT UPF0234 protein EQJ69_06505 ENOG4105QNR S1 RNA binding domain protein EQJ69_06520 ENOG4105EPR degv family EQJ69_06525 ENOG4107AYK membrAne EQJ69_06535 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) EQJ69_06540 ENOG41073B9 EQJ69_06545 ENOG4108KP7 hydrolase EQJ69_06550 ENOG4108MXZ Esterase EQJ69_06555 ENOG4105VG1 fes assembly suf system protein EQJ69_06565 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EQJ69_06570 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EQJ69_06575 ENOG4105CAS nag kinase EQJ69_06580 ENOG4105C8Y Acetylornithine aminotransferase EQJ69_06585 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EQJ69_06595 ENOG4105DBV ornithine carbamoyltransferase EQJ69_06600 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EQJ69_06625 ENOG4107RMD Basic membrane lipoprotein EQJ69_06640 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EQJ69_06645 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EQJ69_06655 ENOG4105C3U ABC transporter EQJ69_06660 ENOG4108JQ7 (ABC) transporter EQJ69_06675 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQJ69_06690 ENOG4105C31 Tryptophanyl-tRNA synthetase EQJ69_06700 ENOG4108J59 Extracellular solute-binding protein, family 5 EQJ69_06710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQJ69_06720 ENOG4108JQ7 (ABC) transporter EQJ69_06730 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) EQJ69_06735 ENOG4108ZCF integral membrane protein EQJ69_06745 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis EQJ69_06765 ENOG4108V9W transcriptional regulatory protein EQJ69_06770 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EQJ69_06780 ENOG4105DPN Oligoendopeptidase f EQJ69_06785 ENOG4105T58 Dithiol-disulfide isomerase EQJ69_06790 ENOG4108Z18 K06886 hemoglobin EQJ69_06795 ENOG4105E4C Lytic transglycosylase catalytic EQJ69_06800 ENOG4105MIX Adenylate cyclase EQJ69_06805 ENOG4106EFP UPF0738 protein EQJ69_06815 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EQJ69_06820 ENOG4105EMS pseudouridine synthase EQJ69_06825 ENOG4107S1Q Phosphatase EQJ69_06840 ENOG4105ETU transcriptional activator (TenA EQJ69_06845 ENOG4108VEU Thiamine monophosphate synthase EQJ69_06860 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EQJ69_06865 ENOG4105D06 uba thif-type nad fad binding protein EQJ69_06870 ENOG4105DWF phosphomethylpyrimidine kinase EQJ69_06875 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EQJ69_06880 ENOG4107A88 EQJ69_06930 ENOG4105ENA helicase EQJ69_06940 ENOG4107T5V SNARE associated Golgi EQJ69_06945 ENOG4105CMR udp-glucose 4-epimerase EQJ69_06950 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EQJ69_06965 ENOG4108ZMI UPF0477 protein EQJ69_06990 ENOG4105C28 cystathionine EQJ69_06995 ENOG4105C28 cystathionine EQJ69_07000 ENOG4105JHY Membrane EQJ69_07020 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase EQJ69_07040 ENOG4108UW5 maltose o-acetyltransferase EQJ69_07050 ENOG4105DUM transcriptional regulator, lysR family EQJ69_07055 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EQJ69_07060 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EQJ69_07070 ENOG4108Q5Y Membrane EQJ69_07075 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase EQJ69_07085 ENOG41069ER domain protein EQJ69_07090 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQJ69_07095 ENOG4105J7D transcriptional regulator EQJ69_07120 ENOG4105K7W phage-related replication protein EQJ69_07125 ENOG410635T phage-like element pbsx protein EQJ69_07170 ENOG4108TFU terminase (Small subunit) EQJ69_07175 ENOG4105IG6 Phage terminase, large subunit EQJ69_07180 ENOG4108MDF Phage Portal Protein EQJ69_07205 ENOG41060SN EQJ69_07220 ENOG4105PQS phage protein EQJ69_07225 ENOG4105FR7 XkdM protein, phage-like element PBSX EQJ69_07230 ENOG4105MTC XkdN-like protein EQJ69_07240 ENOG4108FKH Transglycosylase SLT domain EQJ69_07245 ENOG4108WZM domain protein EQJ69_07250 ENOG4105X7F EQJ69_07260 ENOG4105MFU Protein of unknown function (DUF2634) EQJ69_07265 ENOG41066EA baseplate J family protein EQJ69_07270 ENOG410906S phage-like element pbsx protein xkdt EQJ69_07280 ENOG41068G1 EQJ69_07285 ENOG41068G1 EQJ69_07300 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EQJ69_07305 ENOG4107XBN GntR Family Transcriptional Regulator EQJ69_07310 ENOG4105CPQ Dehydrogenase EQJ69_07315 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) EQJ69_07320 ENOG4105DMW Dehydrogenase reductase EQJ69_07325 ENOG4105CPQ Dehydrogenase EQJ69_07330 ENOG4108I5G Major Facilitator superfamily EQJ69_07345 ENOG4105CJ3 phosphate transporter EQJ69_07350 ENOG4107GRR phosphate transport regulator EQJ69_07355 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EQJ69_07365 ENOG4105C2F Histidine kinase EQJ69_07370 ENOG4105EQD regulatoR EQJ69_07375 ENOG410769Z extracellular solute-binding protein family 1 EQJ69_07380 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EQJ69_07385 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EQJ69_07390 ENOG4105F5H Glycosyl Hydrolase Family 88 EQJ69_07395 ENOG41075H3 AraC family transcriptional regulator EQJ69_07400 ENOG4107TDE lipolytic protein G-D-S-L family EQJ69_07415 ENOG4105CX8 fg-gap repeat protein EQJ69_07425 ENOG4107TDE lipolytic protein G-D-S-L family EQJ69_07430 ENOG4105CX8 fg-gap repeat protein EQJ69_07435 ENOG4105CPC Aldo Keto reductase EQJ69_07440 ENOG4107TDE lipolytic protein G-D-S-L family EQJ69_07450 ENOG4105EKC EQJ69_07455 ENOG4105E0S extracellular solute-binding protein family 1 EQJ69_07465 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EQJ69_07470 ENOG4107R7I amino acid EQJ69_07485 ENOG4105C0H protease EQJ69_07495 ENOG4108ME1 Peptidase M55 D-aminopeptidase EQJ69_07500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQJ69_07505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQJ69_07510 ENOG4105C3U ABC transporter EQJ69_07520 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EQJ69_07525 ENOG4105DTQ mandelate racemase muconate lactonizing EQJ69_07530 ENOG4107SN7 NLP P60 protein EQJ69_07535 ENOG4108JQ7 (ABC) transporter EQJ69_07540 ENOG4107TUM Amidinotransferase EQJ69_07545 ENOG4108S4H thioesterase Superfamily protein EQJ69_07555 ENOG4108J20 pectate lyase EQJ69_07580 ENOG410839T multidrug resistance protein EQJ69_07585 ENOG41080TC multidrug resistance protein EQJ69_07590 ENOG4105CIY formyltetrahydrofolate deformylase EQJ69_07595 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EQJ69_07600 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EQJ69_07610 ENOG4105K56 Transcriptional regulator EQJ69_07615 ENOG4108ZHJ Organic hydroperoxide resistance protein EQJ69_07625 ENOG4107Y2X deaminase EQJ69_07630 ENOG4105CVJ phosphoglycerate mutase EQJ69_07645 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EQJ69_07650 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQJ69_07660 ENOG4105CJW magnesium transporter EQJ69_07670 ENOG4105V75 Transcriptional regulator EQJ69_07690 ENOG4105DQE DNA ligase EQJ69_07695 ENOG4105FDF Could be involved in DNA repair (By similarity) EQJ69_07700 ENOG4105BZU Histidine kinase EQJ69_07705 ENOG4107T5V SNARE associated Golgi EQJ69_07710 ENOG4107TS3 membrane protein, TerC EQJ69_07715 ENOG4108WZW RNA polymerase sigma EQJ69_07725 ENOG410681C small acid-soluble spore protein EQJ69_07735 ENOG4105D0M Protease HtpX homolog EQJ69_07745 ENOG4107RVG penicillin-binding protein EQJ69_07760 ENOG4108TGC Acyltransferase EQJ69_07765 ENOG4105BZU Histidine kinase EQJ69_07770 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EQJ69_07775 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EQJ69_07785 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EQJ69_07795 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate EQJ69_07805 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EQJ69_07810 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) EQJ69_07825 ENOG4105BZU Histidine kinase EQJ69_07830 ENOG41090MY MarR family Transcriptional regulator EQJ69_07835 ENOG4105ER2 Ompa motb domain protein EQJ69_07840 ENOG4105E14 MotA TolQ exbB proton channel EQJ69_07850 ENOG4108K88 Membrane EQJ69_07855 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EQJ69_07860 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase EQJ69_07865 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EQJ69_07870 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EQJ69_07880 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQJ69_07885 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQJ69_07915 ENOG4108J9Q DNA ligase EQJ69_07995 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQJ69_08045 ENOG4108FKH Transglycosylase SLT domain EQJ69_08065 ENOG41068G1 EQJ69_08085 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase EQJ69_08100 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) EQJ69_08120 ENOG4105VTR Integrase EQJ69_08135 ENOG4105NX3 Membrane EQJ69_08140 ENOG4105VMP Transcriptional regulator EQJ69_08180 ENOG4105F0V Cell wall hydrolase EQJ69_08195 ENOG4105C59 p-type ATPase EQJ69_08200 ENOG4105DC7 peptidase M24 EQJ69_08215 ENOG4105CID antiterminator EQJ69_08225 ENOG4105KRI phosphocarrier protein (HPr EQJ69_08230 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EQJ69_08240 ENOG4105F6S Spore photoproduct lyase EQJ69_08250 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EQJ69_08255 ENOG4105CHR reductase EQJ69_08260 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EQJ69_08265 ENOG4105K4I Scp-like extracellular EQJ69_08275 ENOG4105BZU Histidine kinase EQJ69_08280 ENOG4105CHM Aminotransferase EQJ69_08295 ENOG4107R88 Chemotaxis protein (CheV) EQJ69_08300 ENOG4105UIN EQJ69_08310 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein EQJ69_08325 ENOG4105K6S Short-chain dehydrogenase reductase Sdr EQJ69_08330 ENOG4105EPM Diguanylate phosphodiesterase EQJ69_08340 ENOG4107IN1 Protein of unknown function (DUF1797) EQJ69_08345 ENOG4108XRC Protein of unknown function (DUF458) EQJ69_08375 ENOG4105NQC Flavodoxin EQJ69_08380 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) EQJ69_08395 ENOG4105D3R alkyl hydroperoxide reductase EQJ69_08400 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQJ69_08415 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EQJ69_08420 ENOG4105D06 uba thif-type nad fad binding protein EQJ69_08425 ENOG4105CVM Molybdenum cofactor synthesis domain protein EQJ69_08430 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein EQJ69_08435 ENOG4108ZAF Molybdopterin EQJ69_08440 ENOG41067WU Molybdopterin converting factor (Subunit 1) EQJ69_08450 ENOG4105BZ1 (ABC) transporter EQJ69_08455 ENOG4105BZ1 (ABC) transporter EQJ69_08465 ENOG4107X8C Efflux transporter RND family MFP subunit EQJ69_08470 ENOG4105C19 ABC transporter EQJ69_08475 ENOG4107RBB ABC transporter, permease EQJ69_08480 ENOG4105E98 transcriptional regulator DeoR family EQJ69_08485 ENOG4105DE4 1-phosphofructokinase EQJ69_08490 ENOG4105DM4 PTS System EQJ69_08495 ENOG4105C3F Signal peptidase i EQJ69_08510 ENOG4105C5H ABC transporter EQJ69_08540 ENOG4105BZU Histidine kinase EQJ69_08545 ENOG4107ZYR domain protein EQJ69_08555 ENOG4105CN5 Metallo-Beta-Lactamase EQJ69_08565 ENOG4108X4Q Hydrolase EQJ69_08570 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EQJ69_08590 ENOG4105CPP Dehydrogenase, E1 component EQJ69_08595 ENOG4105C7S Dehydrogenase EQJ69_08600 ENOG4107QN2 dihydrolipoyl dehydrogenase EQJ69_08620 ENOG4105CXN decarboxylase EQJ69_08630 ENOG4105WBI UPF0223 protein EQJ69_08645 ENOG4105ECY inositol monophosphatase EQJ69_08680 ENOG4105CI3 gtp-binding protein typa EQJ69_08685 ENOG4105QA2 EQJ69_08690 ENOG4108INS Transcriptional regulator EQJ69_08695 ENOG4107SCK Monooxygenase EQJ69_08710 ENOG4108IAB Phoh family EQJ69_08720 ENOG4105CSV Glutaminase EQJ69_08725 ENOG4105ZPI UPF0358 protein EQJ69_08730 ENOG4105CNI cell division protein FtsW EQJ69_08735 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EQJ69_08745 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EQJ69_08755 ENOG4105BZ9 Cytochrome C oxidase, subunit I EQJ69_08760 ENOG4105CCU oxidase (Subunit III) EQJ69_08765 ENOG41064X9 cytochrome C oxidase subunit IV EQJ69_08780 ENOG41080XQ Signal transduction protein with cbs domains EQJ69_08785 ENOG4106UY4 Inherit from COG: Scp-like extracellular EQJ69_08810 ENOG4106H78 methyltransferase EQJ69_08815 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EQJ69_08820 ENOG4105H20 Sporulation integral membrane protein YlbJ EQJ69_08825 ENOG41063PX domain protein EQJ69_08830 ENOG4105CDE UPF0348 protein EQJ69_08835 ENOG4105KNH Nucleic acid-binding protein EQJ69_08840 ENOG41067VY 50S ribosomal protein L32 EQJ69_08860 ENOG41074B2 UPF0747 protein EQJ69_08865 ENOG4108V6E Cell division protein mraZ EQJ69_08870 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EQJ69_08880 ENOG4105CJN penicillin-binding protein EQJ69_08885 ENOG4105CJN penicillin-binding protein EQJ69_08890 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EQJ69_08895 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EQJ69_08900 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EQJ69_08905 ENOG4105CNI cell division protein FtsW EQJ69_08910 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EQJ69_08915 ENOG4105D4A Cell wall formation (By similarity) EQJ69_08920 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) EQJ69_08925 ENOG4108R2U division initiation protein EQJ69_08935 ENOG4105K67 small basic protein EQJ69_08940 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EQJ69_08945 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EQJ69_08965 ENOG4105FFI sigma-e processing peptidase spoiiga EQJ69_08970 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQJ69_08980 ENOG4105DKW ABC transporter EQJ69_08985 ENOG4105DHI Methyltransferase EQJ69_08990 ENOG4105WR5 sporulation protein, YlmC YmxH family EQJ69_08995 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EQJ69_09000 ENOG4105DFA alanine racemase domain protein EQJ69_09005 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EQJ69_09010 ENOG41067XK integral membrane protein EQJ69_09015 ENOG4105DBK s4 domain protein EQJ69_09035 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EQJ69_09040 ENOG4105C34 Pseudouridine synthase EQJ69_09045 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EQJ69_09055 ENOG4105CXT aspartate transcarbamylase EQJ69_09060 ENOG4105CD3 dihydroorotase EQJ69_09065 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EQJ69_09070 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EQJ69_09075 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EQJ69_09080 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) EQJ69_09085 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EQJ69_09100 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EQJ69_09120 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EQJ69_09125 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EQJ69_09130 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein EQJ69_09135 ENOG4105F23 Fibronectin-binding protein EQJ69_09145 ENOG4105DSJ YicC domain protein EQJ69_09150 ENOG4105KC4 UPF0296 protein EQJ69_09155 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EQJ69_09160 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) EQJ69_09165 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EQJ69_09170 ENOG4105C25 Primosomal protein n' EQJ69_09175 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EQJ69_09180 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EQJ69_09185 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EQJ69_09190 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EQJ69_09195 ENOG4108ZF3 Phosphatase EQJ69_09200 ENOG4105D9P serine threonine protein kinase EQJ69_09205 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EQJ69_09210 ENOG4105DJV ribulose-phosphate 3-epimerase EQJ69_09215 ENOG4105FJ0 thiamine EQJ69_09225 ENOG4105VB9 50S ribosomal protein l28 EQJ69_09230 ENOG4108ZAA Alkaline-shock protein EQJ69_09235 ENOG4105DP4 dak2 domain fusion protein ylov EQJ69_09245 ENOG4105EJQ L-serine dehydratase EQJ69_09250 ENOG4105CB5 ATP-dependent DNA helicase recG EQJ69_09255 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) EQJ69_09260 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EQJ69_09265 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EQJ69_09270 ENOG4105CHR reductase EQJ69_09275 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EQJ69_09280 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EQJ69_09285 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EQJ69_09290 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EQJ69_09295 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) EQJ69_09305 ENOG4105K5M 30s ribosomal protein S16 EQJ69_09310 ENOG4108BW8 UPF0109 protein EQJ69_09320 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EQJ69_09325 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EQJ69_09330 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EQJ69_09335 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EQJ69_09340 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EQJ69_09350 ENOG4105VM1 flagellar EQJ69_09355 ENOG4105CMV Succinyl-CoA synthetase subunit beta EQJ69_09360 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EQJ69_09365 ENOG4105C79 DNA protecting protein DprA EQJ69_09370 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EQJ69_09375 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) EQJ69_09380 ENOG4108HE4 integrase family EQJ69_09385 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) EQJ69_09390 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) EQJ69_09395 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) EQJ69_09400 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EQJ69_09405 ENOG4108ZC9 flagellar basal-body rod protein flgc EQJ69_09410 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EQJ69_09415 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EQJ69_09420 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EQJ69_09435 ENOG4106YF4 Flagellar biosynthesis chaperone EQJ69_09445 ENOG410696Y Flagellar hook-length control protein EQJ69_09450 ENOG410822I Flagellar hook capping protein EQJ69_09455 ENOG4108JQA flagellar EQJ69_09460 ENOG41068WV flagellar FlbD family protein EQJ69_09470 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EQJ69_09475 ENOG4105DD5 Flagellar motor switch protein EQJ69_09480 ENOG4107YTP response regulator receiver protein EQJ69_09490 ENOG4105CN7 Flagellar biosynthetic protein FliP EQJ69_09495 ENOG4105VS8 Flagellar biosynthetic protein fliq EQJ69_09500 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EQJ69_09505 ENOG4105D00 flagellar biosynthetic protein flhB EQJ69_09510 ENOG4105D7B Flagellar biosynthesis protein flha EQJ69_09515 ENOG4105FZW flagellar biosynthesis regulator FlhF EQJ69_09525 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EQJ69_09530 ENOG4105CBS Chea signal transduction histidine kinase EQJ69_09535 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis EQJ69_09545 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) EQJ69_09550 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQJ69_09560 ENOG4105CE9 30S ribosomal protein S2 EQJ69_09565 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EQJ69_09575 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EQJ69_09580 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EQJ69_09585 ENOG4105KNE Phosphatidate cytidylyltransferase EQJ69_09595 ENOG4105DZP Membrane-associated zinc metalloprotease EQJ69_09605 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EQJ69_09620 ENOG4105CYP glycoside hydrolase, family EQJ69_09635 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EQJ69_09640 ENOG4105CHV Transcription elongation factor NusA EQJ69_09645 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination EQJ69_09650 ENOG4105VHM ribosomal protein EQJ69_09655 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EQJ69_09660 ENOG4105W7A Protein of unknown function (DUF503) EQJ69_09665 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EQJ69_09670 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EQJ69_09675 ENOG4105DTN riboflavin biosynthesis protein ribF EQJ69_09680 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EQJ69_09685 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EQJ69_09695 ENOG4105C1V Peptidase, M16 EQJ69_09705 ENOG4105E35 Dipicolinate synthase subunit A EQJ69_09710 ENOG4108S0H Dipicolinic acid synthetase, b subunit EQJ69_09715 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EQJ69_09725 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQJ69_09735 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit EQJ69_09745 ENOG4105CNU cell division protein FtsK EQJ69_09750 ENOG4105FDP GntR family transcriptional regulator EQJ69_09770 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EQJ69_09775 ENOG4105XZV Protein of unknown function (DUF3243) EQJ69_09790 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EQJ69_09795 ENOG4105CEV competence damage-inducible protein EQJ69_09800 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EQJ69_09810 ENOG4105D48 metallophosphoesterase EQJ69_09815 ENOG4105MCT stage V sporulation protein S EQJ69_09820 ENOG4108IGT Dipeptidase EQJ69_09825 ENOG4105CPQ Dehydrogenase EQJ69_09830 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EQJ69_09835 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQJ69_09850 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EQJ69_09855 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EQJ69_09865 ENOG4107EV6 Inherit from COG: YD repeat protein EQJ69_09885 ENOG4105CKI cobalamin synthesis protein EQJ69_09895 ENOG4107TCE N-acetyltransferase EQJ69_09915 ENOG4105XPP Protein of unknown function (DUF1275) EQJ69_09920 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) EQJ69_09945 ENOG41080BT SNARE associated Golgi EQJ69_09950 ENOG4105FQP Beta-lactamase EQJ69_09955 ENOG41087PP glycosyltransferase MGT family EQJ69_09960 ENOG4107QTZ amino acid EQJ69_09975 ENOG4105VRS hydrolase family 18 EQJ69_09980 ENOG4105M4P Tetr family transcriptional regulator EQJ69_09985 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein EQJ69_09990 ENOG4107S9F NmrA family EQJ69_10000 ENOG4108X3M OsmC Ohr family protein EQJ69_10005 ENOG4107E54 Small Multidrug Resistance protein EQJ69_10025 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EQJ69_10030 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EQJ69_10045 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EQJ69_10050 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQJ69_10055 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQJ69_10060 ENOG4105U6W MutT NUDIX family protein EQJ69_10070 ENOG4108UNV SUF system FeS assembly protein, NifU family EQJ69_10075 ENOG4105G5W regulator Fur family EQJ69_10080 ENOG4105DRR Transcriptional regulator, GntR family EQJ69_10120 ENOG4105PF9 Transcriptional regulator EQJ69_10170 ENOG4106F1P AAA ATPase, central domain protein EQJ69_10175 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EQJ69_10180 ENOG4105CXI aluminum resistance protein EQJ69_10185 ENOG4105KV4 Transcriptional regulator EQJ69_10190 ENOG4105C5F glutamine synthetase EQJ69_10215 ENOG4105K59 histidine triad (HIT) protein EQJ69_10325 ENOG41062JF Transcriptional regulator EQJ69_10330 ENOG41090MY MarR family Transcriptional regulator EQJ69_10335 ENOG4108TVJ Nitroreductase EQJ69_10340 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase EQJ69_10345 ENOG4107XWI flavin reductase domain protein, FMN-binding EQJ69_10350 ENOG4105CS1 NAD(P)H quinone oxidoreductase EQJ69_10365 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EQJ69_10370 ENOG4105WFK nuclease EQJ69_10375 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EQJ69_10385 ENOG4108SVB resolvase EQJ69_10390 ENOG4105VPS UPF0291 protein EQJ69_10395 ENOG4105CV1 Transketolase (EC 2.2.1.1) EQJ69_10405 ENOG4105VXM UPF0154 protein EQJ69_10415 ENOG4107QIV Cytochrome c biogenesis protein EQJ69_10440 ENOG41076DU acid-soluble spore protein P EQJ69_10450 ENOG4108I0Z Aconitate hydratase EQJ69_10455 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQJ69_10480 ENOG4105MI2 EQJ69_10500 ENOG4105W8X HesB YadR YfhF-family protein EQJ69_10505 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EQJ69_10510 ENOG4105K4P CoA-binding domain protein EQJ69_10515 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQJ69_10525 ENOG4105CMD Transcriptional regulator, GntR family EQJ69_10540 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) EQJ69_10545 ENOG4107QNK )-transporter EQJ69_10550 ENOG4105CHR reductase EQJ69_10575 ENOG4105R3A Nitrate reductase EQJ69_10580 ENOG4108IUE nitrate reductase beta subunit EQJ69_10615 ENOG4107V6Q Cyclic nucleotide-binding domain EQJ69_10635 ENOG4105DSQ Nitric oxide reductase EQJ69_10640 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) EQJ69_10645 ENOG4106U2H Protein of unknown function (DUF1360) EQJ69_10650 ENOG4107QWR cellulase (EC 3.2.1.4) EQJ69_10660 ENOG4108428 Inherit from COG: -acetyltransferase EQJ69_10670 ENOG4105C3M thioredoxin reductase EQJ69_10685 ENOG4108M26 parallel beta-helix repeat protein EQJ69_10695 ENOG4105DQ4 alcohol dehydrogenase EQJ69_10700 ENOG4105VUF Transcriptional regulator EQJ69_10725 ENOG41060WC Enoyl-CoA hydratase EQJ69_10730 ENOG4105C26 Dehydrogenase EQJ69_10735 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EQJ69_10740 ENOG4105C1G acyl-Coa dehydrogenase EQJ69_10745 ENOG4105DG6 mannose-6-phosphate isomerase EQJ69_10750 ENOG4105DM4 PTS System EQJ69_10790 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EQJ69_10795 ENOG4105DMW Dehydrogenase reductase EQJ69_10800 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) EQJ69_10810 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EQJ69_10815 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter EQJ69_10820 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EQJ69_10825 ENOG4107KJX Transcriptional regulator EQJ69_10830 ENOG4108UXE Protein tyrosine phosphatase EQJ69_10835 ENOG4107R5R arsenical pump membrane protein EQJ69_10840 ENOG41082YX Transcriptional regulator, arsr family EQJ69_10850 ENOG4105CZ9 Domain of unknown function (DU1801) EQJ69_10860 ENOG4105CSC Glucose uptake protein EQJ69_10865 ENOG4105F32 YngK protein EQJ69_10875 ENOG4105F1A Pyruvate formate-lyase EQJ69_10885 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family EQJ69_10915 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EQJ69_10920 ENOG4107QX3 carboxylase EQJ69_10925 ENOG4105E39 Enoyl-CoA hydratase EQJ69_10930 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EQJ69_10935 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit EQJ69_10940 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EQJ69_10945 ENOG4105CEY Amp-dependent synthetase and ligase EQJ69_10950 ENOG4105C1G acyl-Coa dehydrogenase EQJ69_10955 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EQJ69_10960 ENOG4105KVH Transcriptional regulator EQJ69_10965 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EQJ69_10970 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EQJ69_10980 ENOG4105H67 Protein of unknown function (DUF421) EQJ69_10995 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EQJ69_11000 ENOG41061P3 phosphosulfolactate synthase EQJ69_11010 ENOG4105DIA mandelate racemase muconate lactonizing EQJ69_11015 ENOG4107RCC Major Facilitator Superfamily EQJ69_11035 ENOG4105BZ8 glutamate synthase EQJ69_11040 ENOG4105CBC glutamate synthase EQJ69_11045 ENOG4105C5Q Transcriptional regulator EQJ69_11075 ENOG4105BZ1 (ABC) transporter EQJ69_11090 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EQJ69_11100 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQJ69_11105 ENOG4108J2R molybdopterin oxidoreductase EQJ69_11120 ENOG4108Q8B Spore germination protein EQJ69_11125 ENOG4108NHD germination protein EQJ69_11130 ENOG4108Q8B Spore germination protein EQJ69_11135 ENOG4108Q8B Spore germination protein EQJ69_11150 ENOG4105C8Q Methyl-accepting chemotaxis EQJ69_11155 ENOG4108Z7R Chaperone CsaA EQJ69_11160 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQJ69_11170 ENOG4108RZE Tetr family transcriptional regulator EQJ69_11180 ENOG4105T9C HD domain EQJ69_11190 ENOG4105FVX EQJ69_11210 ENOG4108W8B Beta-lactamase domain protein EQJ69_11225 ENOG4105D29 Helix-turn-helix type 11 domain protein EQJ69_11235 ENOG4105KTU Transcriptional regulator, arsr family EQJ69_11250 ENOG4105CUB amino acid EQJ69_11260 ENOG4105C5E polysaccharide biosynthesis protein EQJ69_11275 ENOG4107T8Q Glycosyl transferase (Group 1 EQJ69_11280 ENOG4108SJC Membrane EQJ69_11295 ENOG4107RUZ Sss sodium solute transporter superfamily EQJ69_11300 ENOG41069ER domain protein EQJ69_11305 ENOG4105C9U ATP-dependent DNA helicase RecQ EQJ69_11325 ENOG4105UNS Pfam:DUF419 EQJ69_11405 ENOG4108NHD germination protein EQJ69_11420 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EQJ69_11435 ENOG4107S9D Alpha beta hydrolase EQJ69_11455 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EQJ69_11465 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EQJ69_11470 ENOG4105ST3 Transcriptional regulator EQJ69_11490 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EQJ69_11495 ENOG4105SCY DNAK suppressor EQJ69_11510 ENOG4105C26 Dehydrogenase EQJ69_11530 ENOG4105EWU Squalene--hopene cyclase EQJ69_11535 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EQJ69_11545 ENOG4105C8J )-transporter EQJ69_11550 ENOG4105C09 Bile acid EQJ69_11555 ENOG4105C7S Dehydrogenase EQJ69_11560 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EQJ69_11565 ENOG4107T89 von Willebrand factor, type A EQJ69_11570 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EQJ69_11580 ENOG4105K4H Nlp p60 protein EQJ69_11610 ENOG4105FR1 rard protein EQJ69_11620 ENOG4108YQE rare lipoprotein a EQJ69_11630 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EQJ69_11645 ENOG4105FBA Phospholipase Carboxylesterase EQJ69_11655 ENOG4105E1V na solute symporter EQJ69_11675 ENOG4108VXD carboxy-peptidase EQJ69_11680 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EQJ69_11685 ENOG4108PJD permease EQJ69_11700 ENOG4106Z5R EQJ69_11705 ENOG410841Q phosphoesterase PA-phosphatase related protein EQJ69_11720 ENOG4105VSD UPF0346 protein EQJ69_11730 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EQJ69_11735 ENOG4108TSC N-acetyltransferase EQJ69_11740 ENOG4107S4Y M20 DapE family protein YgeY EQJ69_11755 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EQJ69_11775 ENOG4105E0X reductase EQJ69_11795 ENOG4105BZU Histidine kinase EQJ69_11815 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) EQJ69_11820 ENOG41090WU lipolytic protein G-D-S-L family EQJ69_11825 ENOG4108KF3 Electron transport protein SCO1 SenC EQJ69_11840 ENOG4105C7B Threonine dehydratase EQJ69_11850 ENOG4108UT2 hemolysin iii EQJ69_11860 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) EQJ69_11875 ENOG4107YX5 Pfam:DUF548 EQJ69_11885 ENOG4105C01 Dihydroxy-acid dehydratase EQJ69_11900 ENOG4108V06 Glutathione peroxidase EQJ69_11905 ENOG4105CKU formyltetrahydrofolate synthetase EQJ69_11910 ENOG4105CVG Homoserine O-transsuccinylase EQJ69_11915 ENOG4108QBV Monogalactosyldiacylglycerol synthase EQJ69_11955 ENOG41081VK Ribonuclease EQJ69_11975 ENOG410890F Dynamin family EQJ69_11990 ENOG41065KQ synthase EQJ69_11995 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EQJ69_12000 ENOG4105C2W permease EQJ69_12005 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) EQJ69_12010 ENOG4105CTD carboxy-peptidase EQJ69_12015 ENOG4105DVT helicase EQJ69_12025 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EQJ69_12035 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) EQJ69_12040 ENOG4108UKS UPF0398 protein EQJ69_12050 ENOG4107X2U Inherit from COG: Exonuclease-like protein EQJ69_12055 ENOG4108I5C dEAD DEAH box helicase EQJ69_12105 ENOG4105BZ4 penicillin-binding protein EQJ69_12115 ENOG4105CSM endonuclease III EQJ69_12130 ENOG4105CHM Aminotransferase EQJ69_12140 ENOG4105YAC EQJ69_12145 ENOG4105DVT helicase EQJ69_12150 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) EQJ69_12155 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EQJ69_12160 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EQJ69_12175 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EQJ69_12180 ENOG4105CPK Glycosyl transferase (Group 1 EQJ69_12185 ENOG4105FJR Lmbe family EQJ69_12190 ENOG4108Z5K methylglyoxal synthase EQJ69_12195 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EQJ69_12200 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase EQJ69_12205 ENOG4108JYZ YitT family EQJ69_12225 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EQJ69_12240 ENOG4108SXZ UPF0302 protein EQJ69_12245 ENOG41068YB TPR repeat-containing protein EQJ69_12260 ENOG4105CIH Imidazole acetol-phosphate transaminase EQJ69_12265 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EQJ69_12270 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EQJ69_12280 ENOG4105DK0 Indole-3-glycerol phosphate synthase EQJ69_12285 ENOG4108I0Q anthranilate phosphoribosyltransferase EQJ69_12290 ENOG4105CRQ synthase (Component I) EQJ69_12295 ENOG4105KHN chorismate mutase EQJ69_12300 ENOG4105D49 3-dehydroquinate synthase EQJ69_12305 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EQJ69_12310 ENOG4105BZU Histidine kinase EQJ69_12315 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EQJ69_12320 ENOG4105EAH synthase EQJ69_12325 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EQJ69_12330 ENOG4105XXQ heptaprenyl diphosphate synthase component I EQJ69_12340 ENOG4105EUJ GTP cyclohydrolase i EQJ69_12345 ENOG4105K70 DNA-binding protein EQJ69_12350 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) EQJ69_12370 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EQJ69_12375 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EQJ69_12380 ENOG41065D1 EQJ69_12385 ENOG4105S2F EQJ69_12400 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EQJ69_12405 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EQJ69_12410 ENOG4105CAT Cytidine monophosphate kinase EQJ69_12415 ENOG4105MSI germination protein ypeb EQJ69_12430 ENOG4105HDK L-asparaginase EQJ69_12435 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase EQJ69_12450 ENOG4107RGJ metallophosphoesterase EQJ69_12465 ENOG4105I7S Abortive infection protein EQJ69_12470 ENOG4105C9U ATP-dependent DNA helicase RecQ EQJ69_12475 ENOG4105T7X EQJ69_12485 ENOG4108SAX Membrane EQJ69_12490 ENOG4108JQ1 Dehydrogenase EQJ69_12495 ENOG4105DR5 peptidase EQJ69_12530 ENOG4105US7 Histidine kinase EQJ69_12535 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQJ69_12540 ENOG4105BZU Histidine kinase EQJ69_12545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQJ69_12550 ENOG4105CRE cytochrome C EQJ69_12555 ENOG4107TWT Cytochrome c biogenesis protein EQJ69_12560 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQJ69_12565 ENOG4105FE9 pseudouridine synthase EQJ69_12575 ENOG4108JIC nucleoside recognition domain protein EQJ69_12580 ENOG4105DZ1 carboxypeptidase EQJ69_12590 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EQJ69_12595 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EQJ69_12615 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EQJ69_12620 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EQJ69_12625 ENOG4108R6K riboflavin synthase, subunit alpha EQJ69_12630 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EQJ69_12640 ENOG4105MEW serine threonine protein phosphatase EQJ69_12645 ENOG4105MYT Heat shock protein EQJ69_12660 ENOG4107ZE5 PPIases accelerate the folding of proteins EQJ69_12665 ENOG4105PTM secreted protein EQJ69_12670 ENOG4105K7W phage-related replication protein EQJ69_12675 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EQJ69_12690 ENOG4105G6R Stage v sporulation protein ae EQJ69_12700 ENOG4105CZ3 stage V sporulation protein ad EQJ69_12705 ENOG41090VF Stage v sporulation protein ac EQJ69_12720 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQJ69_12725 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EQJ69_12730 ENOG41082AN stage II sporulation protein EQJ69_12735 ENOG4105DZ1 carboxypeptidase EQJ69_12740 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) EQJ69_12745 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EQJ69_12750 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQJ69_12760 ENOG4105I3K Ferric uptake regulator, Fur family EQJ69_12765 ENOG4105MZ9 stage II sporulation protein m EQJ69_12770 ENOG4105CK1 PTS System EQJ69_12790 ENOG4107YB6 acetyltransferase, (GNAT) family EQJ69_12800 ENOG4108YZ4 nudix hydrolase EQJ69_12810 ENOG4105PF9 Transcriptional regulator EQJ69_12820 ENOG4105CPC Aldo Keto reductase EQJ69_12840 ENOG4106HZJ EQJ69_12850 ENOG4105RHY Pfam:UPF0157 EQJ69_12855 ENOG4105KAC Antibiotic biosynthesis monooxygenase EQJ69_12865 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold EQJ69_12875 ENOG4107RRN ABC transporter substrate-binding protein EQJ69_12880 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQJ69_12885 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQJ69_12890 ENOG4108RZA ABC transporter EQJ69_12910 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EQJ69_12920 ENOG4105E5W Transporter EQJ69_12925 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase EQJ69_12945 ENOG4105DA5 (ABC) transporter EQJ69_12965 ENOG4105K7W phage-related replication protein EQJ69_12975 ENOG4108IXY short-chain dehydrogenase reductase EQJ69_12980 ENOG41069FQ Metallo-beta-lactamase superfamily EQJ69_12985 ENOG4105II7 pyrroline-5-carboxylate reductase EQJ69_12995 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EQJ69_13005 ENOG4105WDJ 50S ribosomal protein L33 EQJ69_13010 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EQJ69_13015 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EQJ69_13035 ENOG4108TZY GntR Family Transcriptional Regulator EQJ69_13040 ENOG4105CS2 ec 3.2.1.21 EQJ69_13045 ENOG4105CK1 PTS System EQJ69_13050 ENOG4105VCP PTS System EQJ69_13055 ENOG4105VZJ PTS System EQJ69_13060 ENOG4105G6Z alkaline phosphatase EQJ69_13065 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQJ69_13070 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EQJ69_13075 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EQJ69_13085 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) EQJ69_13090 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EQJ69_13095 ENOG4108HNZ carboxyl transferase EQJ69_13100 ENOG4108QEG Membrane EQJ69_13105 ENOG4105CDA abc transporter atp-binding protein EQJ69_13110 ENOG4105E5Q amino acid AbC transporter EQJ69_13115 ENOG4108HW3 (ABC) transporter EQJ69_13120 ENOG4108Y6J UPF0403 protein EQJ69_13125 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) EQJ69_13130 ENOG4105C7S Dehydrogenase EQJ69_13135 ENOG4105CPP Dehydrogenase, E1 component EQJ69_13150 ENOG4105CKM Branched-chain carboxylic acid kinase EQJ69_13155 ENOG4107RDP Dehydrogenase EQJ69_13165 ENOG4108JUB Transcriptional regulator EQJ69_13170 ENOG4106CCJ Protein of unknown function (DUF2627) EQJ69_13175 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EQJ69_13180 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQJ69_13195 ENOG4105D7W serine acetyltransferase EQJ69_13205 ENOG4107QQR Sporulation EQJ69_13210 ENOG4105S1Z Stage IV sporulation protein B EQJ69_13215 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EQJ69_13220 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EQJ69_13225 ENOG4105DX0 Hemolysin A EQJ69_13230 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EQJ69_13235 ENOG4105CTB Polyprenyl synthetase EQJ69_13240 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EQJ69_13245 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EQJ69_13250 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EQJ69_13255 ENOG4105M7K Involved in the transcription termination process (By similarity) EQJ69_13260 ENOG4108ZSR alkaline shock protein EQJ69_13265 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EQJ69_13285 ENOG410644B Stage III sporulation protein af EQJ69_13295 ENOG4105KQ4 Stage iii sporulation protein ad EQJ69_13300 ENOG4108CQH stage III sporulation protein AC EQJ69_13305 ENOG4105KR5 Stage iii sporulation protein EQJ69_13310 ENOG4105CD2 stage iii sporulation protein aa EQJ69_13320 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EQJ69_13325 ENOG4105DC7 peptidase M24 EQJ69_13330 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EQJ69_13340 ENOG4105CBJ Metal-dependent enzyme EQJ69_13355 ENOG4105KST dependent repressor EQJ69_13360 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) EQJ69_13365 ENOG4105WZW rhodanese family EQJ69_13375 ENOG4107SQ8 Glycine betaine EQJ69_13380 ENOG4108IJ7 Glycine betaine EQJ69_13385 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EQJ69_13395 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EQJ69_13400 ENOG4105C0D helicase EQJ69_13425 ENOG4105VFR signal peptidase EQJ69_13465 ENOG4106855 Competence protein EQJ69_13500 ENOG4105C5X domain protein EQJ69_13530 ENOG4105E0M Sulfatase EQJ69_13550 ENOG4107ZXI Rhomboid family EQJ69_13555 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EQJ69_13560 ENOG4105WDJ 50S ribosomal protein L33 EQJ69_13580 ENOG41068DG YceG-like family EQJ69_13585 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EQJ69_13590 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EQJ69_13595 ENOG4105E2Z phosphate ABC transporter (Permease EQJ69_13600 ENOG4105C8U phosphate abc transporter EQJ69_13605 ENOG4105CVA phosphate EQJ69_13610 ENOG4107RF6 penicillin-binding protein EQJ69_13620 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EQJ69_13625 ENOG4105SXS Protein of unknown function (DUF456) EQJ69_13640 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EQJ69_13645 ENOG41063Y9 EQJ69_13650 ENOG4108U5J '-nucleotidase EQJ69_13655 ENOG4105N80 Ferric uptake regulator, Fur family EQJ69_13660 ENOG4105FAV ABC, transporter EQJ69_13665 ENOG4105FDK ABC transporter EQJ69_13670 ENOG4108JYZ YitT family EQJ69_13675 ENOG41069ZM Protein of unknown function (DUF2624) EQJ69_13680 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EQJ69_13695 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EQJ69_13700 ENOG4105EGD dinuclear metal center protein, YbgI family EQJ69_13710 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) EQJ69_13715 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) EQJ69_13775 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQJ69_13780 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EQJ69_13790 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EQJ69_13800 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EQJ69_13805 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit EQJ69_13810 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) EQJ69_13820 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EQJ69_13825 ENOG4105KG3 cytidine deaminase EQJ69_13830 ENOG4107YR5 Diacylglycerol kinase EQJ69_13835 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EQJ69_13840 ENOG4105CTJ Metal Dependent Phosphohydrolase EQJ69_13845 ENOG4105C9A Phoh family EQJ69_13850 ENOG4105EI1 sporulation protein yqfd EQJ69_13855 ENOG41068P3 sporulation protein YqfC EQJ69_13865 ENOG4105DI5 UPF0365 protein EQJ69_13870 ENOG4105F7J membrane-bound serine protease EQJ69_13875 ENOG4105KTH gatB Yqey EQJ69_13880 ENOG4105VCC 30S ribosomal protein S21 EQJ69_13890 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EQJ69_13895 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQJ69_13900 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EQJ69_13905 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EQJ69_13910 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EQJ69_13915 ENOG4105CFG Acts as a chaperone (By similarity) EQJ69_13920 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EQJ69_13925 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EQJ69_13930 ENOG4105CSA Coproporphyrinogen iii oxidase EQJ69_13935 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EQJ69_13945 ENOG4108ZRV stage ii sporulation protein p EQJ69_13960 ENOG4105TQK DNA polymerase iii, delta' subunit EQJ69_13970 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EQJ69_13975 ENOG4108UK2 deaminase EQJ69_13980 ENOG4105KQC Competence protein EQJ69_13990 ENOG4108D32 Methyltransferase EQJ69_14000 ENOG4108WF2 Metal Dependent Phosphohydrolase EQJ69_14005 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EQJ69_14010 ENOG410812S Rna-binding protein EQJ69_14015 ENOG4105E2X shikimate dehydrogenase EQJ69_14020 ENOG4105CQW ribosome biogenesis GTPase YqeH EQJ69_14025 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EQJ69_14040 ENOG4105Z7P Acetyltransferase (GNAT) family EQJ69_14045 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) EQJ69_14050 ENOG4108JB9 formate dehydrogenase EQJ69_14065 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQJ69_14075 ENOG4105VRR gCN5-related N-acetyltransferase EQJ69_14090 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EQJ69_14100 ENOG4105KME endoribonuclease L-psp EQJ69_14110 ENOG4105C6T cysteine synthase EQJ69_14115 ENOG4105KME endoribonuclease L-psp EQJ69_14150 ENOG4105WH1 Two component transcriptional regulator luxr family EQJ69_14155 ENOG4105BZU Histidine kinase EQJ69_14160 ENOG4105XXY Thioredoxin EQJ69_14165 ENOG41087NI Sulfite exporter TauE/SafE EQJ69_14170 ENOG4105VFE sira family EQJ69_14175 ENOG4107TPS domain protein EQJ69_14180 ENOG4105VFE sira family EQJ69_14185 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EQJ69_14190 ENOG4105XTG Pfam:DUF156 EQJ69_14195 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EQJ69_14235 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EQJ69_14260 ENOG41090U3 tautomerase EQJ69_14265 ENOG41080HJ 6-phospho 3-hexuloisomerase EQJ69_14280 ENOG4105ECK Fatty Acid Desaturase EQJ69_14285 ENOG4108ZGX Histidine kinase EQJ69_14290 ENOG4108S01 response regulator EQJ69_14295 ENOG4105CAY ferredoxin--nadp reductase EQJ69_14300 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EQJ69_14305 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQJ69_14310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQJ69_14320 ENOG4108JQ7 (ABC) transporter EQJ69_14335 ENOG4108ZX5 transcriptional regulator EQJ69_14340 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EQJ69_14360 ENOG410635A Membrane EQJ69_14375 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EQJ69_14380 ENOG4108HKT sucrose-6-phosphate hydrolase EQJ69_14385 ENOG4105F3R pts system mannose fructose sorbose family iid EQJ69_14390 ENOG4105ETZ PTS System EQJ69_14395 ENOG4108IQ3 PTS system EQJ69_14405 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQJ69_14415 ENOG4105WDR EQJ69_14430 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EQJ69_14435 ENOG4105CV8 reductase EQJ69_14440 ENOG4105F27 Major Facilitator EQJ69_14445 ENOG4105KVH Transcriptional regulator EQJ69_14450 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) EQJ69_14455 ENOG4105EXQ uroporphyrinogen iii synthase hem4 EQJ69_14465 ENOG4108V5C ABC transporter EQJ69_14470 ENOG4107RSM transcriptional regulator EQJ69_14475 ENOG4105D94 Major Facilitator Superfamily EQJ69_14485 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EQJ69_14490 ENOG41082JN Transcriptional regulator EQJ69_14495 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQJ69_14525 ENOG4105C28 cystathionine EQJ69_14535 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EQJ69_14540 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) EQJ69_14555 ENOG4107XRG penicillin-binding protein EQJ69_14560 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EQJ69_14570 ENOG4105CFP Peptidase U32 EQJ69_14575 ENOG4105XYU peptidase (U32 family) EQJ69_14580 ENOG4108VQJ O-methyltransferase EQJ69_14585 ENOG4105HHA aminodeoxychorismate lyase EQJ69_14590 ENOG4105VPH UPF0473 protein EQJ69_14600 ENOG4105VBH UPF0297 protein EQJ69_14605 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EQJ69_14610 ENOG4105C02 permease EQJ69_14620 ENOG41060CR EQJ69_14630 ENOG4105C7H Helicase, RecD TraA family EQJ69_14640 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EQJ69_14645 ENOG4105C3J Cysteine desulfurase EQJ69_14655 ENOG4105D1H recombination factor protein RarA EQJ69_14660 ENOG4105CUZ uba thif-type nad fad binding protein EQJ69_14670 ENOG4105C9M aspartyl-trna synthetase EQJ69_14675 ENOG4105CUT histidyl-tRNA synthetase EQJ69_14680 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQJ69_14685 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EQJ69_14690 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EQJ69_14695 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EQJ69_14700 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EQJ69_14705 ENOG41067VP Protein of unknown function (DUF1049) EQJ69_14710 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EQJ69_14720 ENOG4105CKP Polysaccharide Biosynthesis Protein EQJ69_14725 ENOG4108QG2 Membrane EQJ69_14730 ENOG4105NAP EQJ69_14735 ENOG4105VIE preprotein translocase, subunit YajC EQJ69_14740 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) EQJ69_14745 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EQJ69_14750 ENOG41061AI Protein of unknown function (DUF2905) EQJ69_14755 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EQJ69_14760 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EQJ69_14775 ENOG41069DP small acid-soluble spore protein EQJ69_14785 ENOG4105K7W phage-related replication protein EQJ69_14800 ENOG4105CDY transcriptional regulatory protein EQJ69_14810 ENOG4106678 morphogenetic protein associated with SpoVID EQJ69_14815 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EQJ69_14820 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EQJ69_14825 ENOG4108IYU L-aspartate oxidase EQJ69_14840 ENOG4105CQC Prephenate dehydratase EQJ69_14845 ENOG41090I5 UPF0735 ACT domain-containing protein EQJ69_14850 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EQJ69_14860 ENOG4105K46 50S ribosomal protein l27 EQJ69_14865 ENOG4105X36 (ribosomal) protein EQJ69_14870 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EQJ69_14890 ENOG41082BM Transcriptional regulator, arsr family EQJ69_14895 ENOG4107QMS site-determining protein EQJ69_14900 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EQJ69_14905 ENOG4105YHC Rod shape-determining protein MreD EQJ69_14910 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EQJ69_14915 ENOG4105DFF Rod shape-determining protein mreb EQJ69_14920 ENOG4105W5Q DNA repair protein (RadC EQJ69_14925 ENOG4108Z03 MAF-like protein EQJ69_14935 ENOG4106A3R peptidase EQJ69_14940 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EQJ69_14945 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EQJ69_14955 ENOG4106AR7 Spore coat protein EQJ69_14960 ENOG41068KH stage VI sporulation protein D EQJ69_14965 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EQJ69_14970 ENOG4105D52 delta-aminolevulinic acid dehydratase EQJ69_14980 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EQJ69_14990 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EQJ69_15000 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EQJ69_15005 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EQJ69_15010 ENOG4108IUQ atp-dependent protease EQJ69_15015 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EQJ69_15020 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EQJ69_15030 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EQJ69_15035 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EQJ69_15040 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EQJ69_15045 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EQJ69_15050 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EQJ69_15055 ENOG4108ZP8 Acetolactate synthase small subunit EQJ69_15060 ENOG4105C7K acetolactate synthase EQJ69_15065 ENOG4105CM2 brancheD-chain amino acid aminotransferase EQJ69_15075 ENOG4107R37 Glutamate dehydrogenase EQJ69_15095 ENOG4108MDF Phage Portal Protein EQJ69_15170 ENOG4105M59 Phosphodiesterase, mj0936 family EQJ69_15175 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EQJ69_15180 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EQJ69_15185 ENOG4108XJQ germination protein EQJ69_15190 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EQJ69_15195 ENOG41067TZ transcriptional regulator, MarR family EQJ69_15200 ENOG4105PFC Transcriptional regulator EQJ69_15205 ENOG4105EMU Dehydrogenase EQJ69_15215 ENOG4105E33 succinate dehydrogenase EQJ69_15225 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit EQJ69_15235 ENOG4105CFH Aspartokinase EQJ69_15245 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EQJ69_15250 ENOG4105K63 Thioredoxin EQJ69_15255 ENOG4105C10 Electron transfer flavoprotein EQJ69_15260 ENOG4105BZJ Electron transfer flavoprotein EQJ69_15265 ENOG41060WC Enoyl-CoA hydratase EQJ69_15270 ENOG4107Z3H Transcriptional regulator, TetR family EQJ69_15275 ENOG4105CEY Amp-dependent synthetase and ligase EQJ69_15285 ENOG4105C98 muts2 protein EQJ69_15290 ENOG4105DCG PHP domain protein EQJ69_15300 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) EQJ69_15305 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EQJ69_15335 ENOG4108IUZ ABC transporter EQJ69_15350 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EQJ69_15355 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EQJ69_15360 ENOG4108RWN rrna methyltransferase EQJ69_15365 ENOG41067MF small acid-soluble spore protein EQJ69_15385 ENOG4105DRS transport system, permease EQJ69_15400 ENOG4108MDK Dehydrogenase EQJ69_15405 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase EQJ69_15410 ENOG4105EF1 ribulokinase EQJ69_15415 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) EQJ69_15420 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase EQJ69_15425 ENOG4105CN9 Peptidase m42 family protein EQJ69_15435 ENOG410696E Membrane EQJ69_15440 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EQJ69_15445 ENOG4105VJV 50s ribosomal protein L35 EQJ69_15450 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EQJ69_15455 ENOG41067MG lrgb family EQJ69_15465 ENOG4105DGI Alkaline phosphatase EQJ69_15470 ENOG4105DY9 regulatoR EQJ69_15475 ENOG4108HRK Histidine kinase EQJ69_15485 ENOG4105U0R haloacid dehalogenase-like hydrolase EQJ69_15490 ENOG4105C22 threonyL-tRNA synthetase EQJ69_15495 ENOG4108TDW sporulation protein YtxC EQJ69_15515 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EQJ69_15530 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) EQJ69_15535 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EQJ69_15540 ENOG4108NR7 pectate lyase EQJ69_15545 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EQJ69_15555 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EQJ69_15560 ENOG4105C2M dna polymerase I EQJ69_15565 ENOG4105BZU Histidine kinase EQJ69_15570 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQJ69_15575 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EQJ69_15580 ENOG4108HMX isocitrate dehydrogenase (NADP) EQJ69_15585 ENOG4105BZN citrate synthase EQJ69_15590 ENOG4108VMM UPF0756 membrane protein EQJ69_15595 ENOG4108REF Sporulation integral membrane protein ytvi EQJ69_15600 ENOG4105FS0 cytoplasmic membrane protein EQJ69_15605 ENOG4105CA9 Pyruvate kinase EQJ69_15610 ENOG4105CTQ phosphohexokinase EQJ69_15615 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) EQJ69_15625 ENOG4105C6K Malic enzyme EQJ69_15630 ENOG4105C0B DNA polymerase III (alpha subunit) EQJ69_15635 ENOG4105VV2 EQJ69_15645 ENOG4106EVM EQJ69_15650 ENOG4105SFS phosphoesterase RecJ domain protein EQJ69_15665 ENOG4105U3E Transcriptional regulator EQJ69_15670 ENOG4105E8R UPF0173 metal-dependent hydrolase EQJ69_15680 ENOG4105CH7 arginosuccinase EQJ69_15685 ENOG4105CDH Citrulline--aspartate ligase EQJ69_15690 ENOG4105EPU Molybdenum cofactor synthesis domain protein EQJ69_15695 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EQJ69_15705 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EQJ69_15710 ENOG4105KBJ sporulation protein ytfj EQJ69_15720 ENOG4105VK3 rdd domain containing protein EQJ69_15725 ENOG4105D07 Signal peptide peptidase, SppA EQJ69_15735 ENOG4105CW7 secretion protein, HlyD family EQJ69_15750 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EQJ69_15760 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EQJ69_15785 ENOG4105U5Y Transcriptional regulator EQJ69_15795 ENOG4105BZU Histidine kinase EQJ69_15800 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EQJ69_15815 ENOG4105KAF membrAne EQJ69_15820 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein EQJ69_15830 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EQJ69_15840 ENOG4105F1V Acetoin utilization protein EQJ69_15845 ENOG4105W87 Cbs domain EQJ69_15850 ENOG4105DGU Histone deacetylase EQJ69_15855 ENOG4105ER2 Ompa motb domain protein EQJ69_15860 ENOG4107R0U MotA TolQ exbB proton channel EQJ69_15865 ENOG4105ETE Transcriptional regulator (LacI family EQJ69_15870 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EQJ69_15895 ENOG4105DFU Cell wall formation (By similarity) EQJ69_15905 ENOG4108VDD TRNA binding domain protein EQJ69_15920 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ EQJ69_15935 ENOG4105C6K Malic enzyme EQJ69_15940 ENOG4105C8F Beta-lactamase domain protein EQJ69_15945 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EQJ69_15955 ENOG4108V15 phosphotransferase enzyme family EQJ69_15960 ENOG4108IUM Glycogen debranching enzyme EQJ69_15975 ENOG4107F58 2'-5' rna ligase EQJ69_15980 ENOG4105C6T cysteine synthase EQJ69_15995 ENOG4107QSE Dipeptidase EQJ69_16000 ENOG4105C7N Xanthine uracil vitamin C permease EQJ69_16005 ENOG4105YW5 deoR family transcriptional regulator EQJ69_16020 ENOG4105CBX hi0933 family EQJ69_16025 ENOG4105C94 Transporter EQJ69_16035 ENOG41085GJ domain protein EQJ69_16050 ENOG4105MU9 integral membrane protein EQJ69_16055 ENOG4105DDC Oxidoreductase domain protein EQJ69_16065 ENOG4105F5H Glycosyl Hydrolase Family 88 EQJ69_16075 ENOG41075H3 AraC family transcriptional regulator EQJ69_16085 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EQJ69_16095 ENOG4105NTD Inherit from COG: Hydrolase EQJ69_16105 ENOG4107V2S Transcriptional regulator EQJ69_16110 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase EQJ69_16115 ENOG4105C8T Leucyl-tRNA synthetase EQJ69_16125 ENOG410605W Major Facilitator EQJ69_16130 ENOG4105D01 (LipO)protein EQJ69_16135 ENOG4106UBQ EQJ69_16140 ENOG4107R34 abc transporter permease protein EQJ69_16145 ENOG4105C19 ABC transporter EQJ69_16155 ENOG4105DVE abc transporter atp-binding protein EQJ69_16160 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EQJ69_16170 ENOG4105N5T Radical SAM Protein EQJ69_16190 ENOG4105E8V Alpha Beta Hydrolase Fold protein EQJ69_16195 ENOG4108Z0R Transferase EQJ69_16200 ENOG4105YVM Phosphoesterase, PA-phosphatase related EQJ69_16205 ENOG4105BZF Glycosyl transferase (Group 1 EQJ69_16210 ENOG4105CAQ asparagine synthetase EQJ69_16215 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EQJ69_16240 ENOG4105D2X ABC transporter substrate-binding protein EQJ69_16250 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EQJ69_16270 ENOG4108RMU ferritin dps family protein EQJ69_16285 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) EQJ69_16290 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EQJ69_16295 ENOG4108V2W Carbonate dehydratase EQJ69_16300 ENOG4105CKI cobalamin synthesis protein EQJ69_16305 ENOG4105DSE periplasmic solute binding protein EQJ69_16335 ENOG4105DTQ mandelate racemase muconate lactonizing EQJ69_16340 ENOG4105CEY Amp-dependent synthetase and ligase EQJ69_16345 ENOG4108IPT Naphthoate synthase EQJ69_16350 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EQJ69_16355 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) EQJ69_16360 ENOG4105E4F Isochorismate synthase EQJ69_16365 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EQJ69_16380 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) EQJ69_16390 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) EQJ69_16395 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) EQJ69_16520 ENOG4105CMD Transcriptional regulator, GntR family EQJ69_16525 ENOG4105N67 Proton-coupled thiamine transporter YuaJ EQJ69_16550 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) EQJ69_16560 ENOG4105CZN Potassium uptake protein EQJ69_16570 ENOG4106DF1 EQJ69_16575 ENOG4108VNY MOSC domain protein EQJ69_16580 ENOG4108JB8 alcohol dehydrogenase EQJ69_16585 ENOG4105C26 Dehydrogenase EQJ69_16590 ENOG4105TRT Transcriptional regulator EQJ69_16600 ENOG4105JQZ Methyltransferase EQJ69_16610 ENOG4105F0F Oxalate decarboxylase EQJ69_16685 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) EQJ69_16710 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EQJ69_16720 ENOG4105EE0 oxidoreductase EQJ69_16725 ENOG4108Z0Z intracellular protease Pfpi family EQJ69_16730 ENOG4105C8Q Methyl-accepting chemotaxis EQJ69_16735 ENOG4105C8Q Methyl-accepting chemotaxis EQJ69_16740 ENOG4105C8Q Methyl-accepting chemotaxis EQJ69_16750 ENOG4105EA8 2-Nitropropane dioxygenase EQJ69_16755 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EQJ69_16780 ENOG4105C37 (CBS) domain EQJ69_16795 ENOG4107PBV potassium channel EQJ69_16800 ENOG4107PBV potassium channel EQJ69_16820 ENOG4105KNA -acetyltransferase EQJ69_16825 ENOG4107QYV phosphohexose isomerase EQJ69_16830 ENOG4107QW4 alcohol dehydrogenase EQJ69_16835 ENOG4105WG9 Conserved Protein EQJ69_16845 ENOG4105CHM Aminotransferase EQJ69_16850 ENOG4108ZB6 transcriptional regulator AsnC family EQJ69_16855 ENOG4108MUZ hydrolase EQJ69_16870 ENOG4105C87 Aminotransferase class I and II EQJ69_16880 ENOG4105Y38 Kinase-associated protein B EQJ69_16895 ENOG4105BZ4 penicillin-binding protein EQJ69_16900 ENOG4105KIR Thiol-disulfide oxidoreductase dcc EQJ69_16915 ENOG4108MRH transcriptional regulatory protein EQJ69_16925 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EQJ69_16930 ENOG4107ZTW SNARE associated Golgi EQJ69_16935 ENOG4105DJ4 phosphatidylserine decarboxylase EQJ69_16950 ENOG4105D65 subunit l EQJ69_16955 ENOG4105HC0 Na H antiporter EQJ69_16960 ENOG4108ZE9 Monovalent cation H antiporter subunit C EQJ69_16965 ENOG4108JPZ Monovalent cation H antiporter subunit D EQJ69_16970 ENOG4105SC1 monovalent cation H antiporter subunit E EQJ69_16980 ENOG4105KJM monovalent cation h antiporter subunit g EQJ69_16985 ENOG4105KA0 thioesterase Superfamily protein EQJ69_16995 ENOG4105BZU Histidine kinase EQJ69_17025 ENOG4105D58 Diguanylate phosphodiesterase EQJ69_17030 ENOG4105DAP Nicotinate phosphoribosyltransferase EQJ69_17055 ENOG4105C02 permease EQJ69_17060 ENOG4108Z40 Transcriptional regulator EQJ69_17080 ENOG410904N short-chain dehydrogenase reductase EQJ69_17115 ENOG4105BZG amino acid carrier protein EQJ69_17120 ENOG4108K8K Transcriptional regulator EQJ69_17125 ENOG4105DCF alanine dehydrogenase EQJ69_17150 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EQJ69_17160 ENOG41069ER domain protein EQJ69_17170 ENOG4105CEP NADH dehydrogenase EQJ69_17175 ENOG4105CAY ferredoxin--nadp reductase EQJ69_17190 ENOG4108YM7 Gcn5-related n-acetyltransferase EQJ69_17195 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EQJ69_17220 ENOG4108ZMX Domain of unknown function (DU1801) EQJ69_17235 ENOG4105PY6 Phenolic acid decarboxylase EQJ69_17250 ENOG41083MR nifu domain-containing protein EQJ69_17255 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein EQJ69_17260 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EQJ69_17265 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) EQJ69_17270 ENOG4105D6E homoserine dehydrogenase EQJ69_17275 ENOG4105C5I Dehydrogenase EQJ69_17285 ENOG4108W5N phosphatidylglycerophosphatase a EQJ69_17290 ENOG4105D4U had-superfamily hydrolase, subfamily iia EQJ69_17300 ENOG4105MMD transcriptional regulator EQJ69_17305 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) EQJ69_17310 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EQJ69_17315 ENOG4105FAA peptidase M23 EQJ69_17325 ENOG4105C8J )-transporter EQJ69_17330 ENOG4108YTE sporulation protein YunB EQJ69_17335 ENOG4105KZD Domain of unknown function (DUF1805) EQJ69_17340 ENOG4107R8B 5'-nucleotidase EQJ69_17350 ENOG4105I3N Conserved Protein EQJ69_17355 ENOG4105IIP Membrane EQJ69_17360 ENOG4105W1N transcriptional regulator EQJ69_17370 ENOG4105C5R Aminotransferase EQJ69_17380 ENOG4105G9B Transcriptional regulator EQJ69_17395 ENOG4108I0Q anthranilate phosphoribosyltransferase EQJ69_17400 ENOG4108I0Q anthranilate phosphoribosyltransferase EQJ69_17405 ENOG4108K8S endonuclease I EQJ69_17415 ENOG4107VFR oxidoreductase EQJ69_17435 ENOG4105DIW FeS assembly protein SUFB EQJ69_17440 ENOG4108UNV SUF system FeS assembly protein, NifU family EQJ69_17445 ENOG4105C9B Cysteine desulfurase EQJ69_17450 ENOG4105JRK feS assembly protein SufD EQJ69_17455 ENOG4105C3K feS assembly ATPase SufC EQJ69_17460 ENOG4105PGM cation diffusion facilitator family transporter EQJ69_17470 ENOG4105D01 (LipO)protein EQJ69_17475 ENOG4108UMI ABC transporter, permease EQJ69_17480 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EQJ69_17505 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EQJ69_17510 ENOG41080E8 Transcriptional regulator, Spx MgsR family EQJ69_17515 ENOG4105C1G acyl-Coa dehydrogenase EQJ69_17520 ENOG4105CHU acetyl-coa acetyltransferase EQJ69_17555 ENOG4105E0A ABC, transporter EQJ69_17560 ENOG4108IHU transport system permease protein EQJ69_17565 ENOG4105DQ5 transport system permease protein EQJ69_17570 ENOG4108MES Periplasmic binding protein EQJ69_17585 ENOG4105DZ1 carboxypeptidase EQJ69_17590 ENOG4105E1F short-chain dehydrogenase reductase EQJ69_17595 ENOG4105HUF DNA protection during starvation protein EQJ69_17600 ENOG4105C0H protease EQJ69_17610 ENOG4105F3H Histidine kinase EQJ69_17615 ENOG41067SE Tetr family transcriptional regulator EQJ69_17620 ENOG4105C9Q fumarate hydratase class II EQJ69_17650 ENOG4105WH1 Two component transcriptional regulator luxr family EQJ69_17655 ENOG4105ENE Histidine kinase EQJ69_17670 ENOG41087YS Phage shock protein A EQJ69_17685 ENOG4108WBT adenosyltransferase EQJ69_17690 ENOG4105CHR reductase EQJ69_17705 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQJ69_17710 ENOG4105E0A ABC, transporter EQJ69_17715 ENOG4105EHG Permease protein EQJ69_17720 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EQJ69_17725 ENOG4105DRR Transcriptional regulator, GntR family EQJ69_17730 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EQJ69_17735 ENOG4108RPX mosc domain containing protein EQJ69_17740 ENOG4105DND Transcriptional regulator EQJ69_17750 ENOG4105CTX dehydratase EQJ69_17755 ENOG4107QZW Altronate oxidoreductase EQJ69_17760 ENOG4107KJX Transcriptional regulator EQJ69_17765 ENOG4105CT4 transporter EQJ69_17770 ENOG4105D2H Uronic isomerase EQJ69_17780 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQJ69_17785 ENOG4105E0A ABC, transporter EQJ69_17790 ENOG4105EHG Permease protein EQJ69_17795 ENOG4105DQ5 transport system permease protein EQJ69_17800 ENOG4105D5Q Arginine ornithine antiporter EQJ69_17810 ENOG4107K5X Membrane-bound metal-dependent hydrolase EQJ69_17815 ENOG4107QZ2 Sulfatase EQJ69_17830 ENOG4105EVU fructokinase EQJ69_17835 ENOG4107EPV Aminotransferase class V EQJ69_17845 ENOG4105EEM helicase EQJ69_17850 ENOG4105EN6 Membrane EQJ69_17855 ENOG4105RHY Pfam:UPF0157 EQJ69_17860 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EQJ69_17870 ENOG4107ZQN disulfide bond EQJ69_17875 ENOG4105C59 p-type ATPase EQJ69_17880 ENOG4108JE9 extracellular solute-binding protein family 1 EQJ69_17885 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EQJ69_17890 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EQJ69_17895 ENOG4105CJQ hydrolase, family 31 EQJ69_17905 ENOG4105DIK (ABC) transporter EQJ69_17910 ENOG4105CC5 ABC transporter EQJ69_17915 ENOG4105DSE periplasmic solute binding protein EQJ69_17925 ENOG4105HX0 Transcriptional regulator EQJ69_17930 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) EQJ69_17935 ENOG4105DM4 PTS System EQJ69_17950 ENOG4105C59 p-type ATPase EQJ69_17955 ENOG410681U heavy metal transport detoxification protein EQJ69_17960 ENOG4105VPX protein, conserved in bacteria EQJ69_17965 ENOG4107RKG DJ-1/PfpI family EQJ69_17970 ENOG4105E98 transcriptional regulator DeoR family EQJ69_17975 ENOG4105DET Rhamnulokinase EQJ69_17980 ENOG4105C9F isomerase EQJ69_17995 ENOG4105F27 Major Facilitator EQJ69_18005 ENOG410625E EQJ69_18010 ENOG4106A3M Cytochrome p-450 EQJ69_18030 ENOG4105D9R oxidoreductase EQJ69_18040 ENOG4105C72 UPF0176 protein EQJ69_18050 ENOG4106DF4 Sigma-70, region 4 EQJ69_18060 ENOG4105F0F Oxalate decarboxylase EQJ69_18105 ENOG4108QY0 Membrane EQJ69_18115 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein EQJ69_18145 ENOG41068G1 EQJ69_18155 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EQJ69_18165 ENOG4108FKH Transglycosylase SLT domain EQJ69_18210 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQJ69_18225 ENOG4105CAR Terminase, large subunit EQJ69_18375 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EQJ69_18380 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EQJ69_18390 ENOG4105XZU Preprotein translocase, subunit SecG EQJ69_18415 ENOG4105R40 Glycine betaine carnitine choline EQJ69_18420 ENOG4108HQR Glycine betaine EQJ69_18425 ENOG4105E90 ABC transporter EQJ69_18430 ENOG4108IJ8 ABC transporter EQJ69_18435 ENOG4107HG4 Transcriptional regulator EQJ69_18440 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EQJ69_18455 ENOG4108MES Periplasmic binding protein EQJ69_18470 ENOG4108V4B ThiJ pfpI EQJ69_18475 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EQJ69_18480 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EQJ69_18485 ENOG4105CP7 Triose-phosphate isomerase EQJ69_18490 ENOG4105BZA Phosphoglycerate kinase EQJ69_18500 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EQJ69_18510 ENOG4105DEN Luciferase family EQJ69_18545 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EQJ69_18550 ENOG4105JXH GntR family transcriptional regulator EQJ69_18555 ENOG4105DAA L-lactate EQJ69_18560 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQJ69_18570 ENOG4108ZPC Polysaccharide pyruvyl transferase EQJ69_18575 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EQJ69_18580 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family EQJ69_18585 ENOG4105D3Q Sugar transferase EQJ69_18595 ENOG4105K64 Glycosyl transferase, family 2 EQJ69_18605 ENOG4107QRS glycosyltransferase group 2 family protein EQJ69_18610 ENOG41068W6 Capsular polysaccharide biosynthesis protein EQJ69_18615 ENOG4108KMV Glycosyl transferase (Group 1 EQJ69_18620 ENOG4105K64 Glycosyl transferase, family 2 EQJ69_18625 ENOG4108PQP glycosyl transferase group 1 EQJ69_18635 ENOG4108QV3 biosynthesis protein EQJ69_18640 ENOG4105HTX biosynthesis protein EQJ69_18650 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EQJ69_18655 ENOG4108I5G Major Facilitator superfamily EQJ69_18665 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EQJ69_18670 ENOG4107S2N Type III effector Hrp-dependent EQJ69_18680 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQJ69_18695 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EQJ69_18700 ENOG4105EDQ levansucrase EC 2.4.1.10 EQJ69_18705 ENOG4108HKT sucrose-6-phosphate hydrolase EQJ69_18720 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQJ69_18725 ENOG4108URH decarboxylase EQJ69_18730 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain EQJ69_18735 ENOG4107TVP HD domain protein EQJ69_18740 ENOG4105CHH sulfate transporter EQJ69_18745 ENOG4108V2W Carbonate dehydratase EQJ69_18750 ENOG4105C5I Dehydrogenase EQJ69_18755 ENOG4108SQ9 flavin reductase domain protein, FMN-binding EQJ69_18760 ENOG4108ZHR arsR family transcriptional regulator EQJ69_18775 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase EQJ69_18780 ENOG4105KRI phosphocarrier protein (HPr EQJ69_18785 ENOG4105CIE May be required for sporulation (By similarity) EQJ69_18790 ENOG4105CHW UPF0052 protein EQJ69_18795 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EQJ69_18800 ENOG4108Z4K mutator MutT protein EQJ69_18810 ENOG4105C3M thioredoxin reductase EQJ69_18825 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EQJ69_18830 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EQJ69_18835 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EQJ69_18840 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EQJ69_18845 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EQJ69_18850 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EQJ69_18855 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EQJ69_18860 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) EQJ69_18870 ENOG4108E16 pectate lyase EQJ69_18875 ENOG4108S4C acetyltransferase EQJ69_18880 ENOG4107XGZ Hydrolase EQJ69_18885 ENOG4105HKU nucleoside recognition domain-containing protein EQJ69_18895 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) EQJ69_18900 ENOG410834F Transcriptional regulator EQJ69_18905 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQJ69_18910 ENOG41088CQ domain protein EQJ69_18915 ENOG41086DT Membrane protein of unknown function EQJ69_18920 ENOG41067S9 phage shock protein C, PspC EQJ69_18925 ENOG4108PY7 EQJ69_18940 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase EQJ69_18950 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EQJ69_18955 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EQJ69_18980 ENOG4105CN1 protease EQJ69_18985 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EQJ69_18995 ENOG4105CRP Part of the ABC transporter FtsEX involved in EQJ69_19000 ENOG4105CAK Cell division ATP-binding protein ftsE EQJ69_19025 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EQJ69_19030 ENOG4105MS2 ribosomal subunit Interface protein EQJ69_19045 ENOG4105MQ3 flagellar protein FliS EQJ69_19050 ENOG4107RT6 flagellar hook-associated EQJ69_19055 ENOG41083S7 flagellar protein FlaG EQJ69_19065 ENOG4105I03 Flagellin EQJ69_19070 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EQJ69_19075 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) EQJ69_19080 ENOG4105MKD EQJ69_19085 ENOG4105DTJ flagellar hook-associated protein EQJ69_19090 ENOG4105E1Q flagellar hook-associated protein EQJ69_19105 ENOG4105RU3 EQJ69_19110 ENOG41081UC Inherit from COG: Competence protein EQJ69_19130 ENOG4105WH1 Two component transcriptional regulator luxr family EQJ69_19135 ENOG4105BZU Histidine kinase EQJ69_19140 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EQJ69_19145 ENOG4108KGH TRANSCRIPTIONal EQJ69_19155 ENOG4105ESV Glycosyl transferase, family 4 EQJ69_19160 ENOG4107EF8 Glycosyl transferase (Group 1 EQJ69_19175 ENOG4105QZI O-Antigen Polymerase EQJ69_19180 ENOG4105C1B dTDP-glucose 4-6-dehydratase EQJ69_19185 ENOG4105C6Y Udp-glucose 6-dehydrogenase EQJ69_19190 ENOG4107RA4 Glycosyl transferase (Group 1 EQJ69_19195 ENOG4105PSV Polysaccharide Biosynthesis Protein EQJ69_19200 ENOG4105D3Q Sugar transferase EQJ69_19205 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQJ69_19210 ENOG4105JFG SpoIID LytB domain protein EQJ69_19220 ENOG4108KGH TRANSCRIPTIONal EQJ69_19225 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EQJ69_19230 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EQJ69_19235 ENOG4105EY8 ABC transporter EQJ69_19255 ENOG4107SJB teichoic acid biosynthesis EQJ69_19260 ENOG4107SJB teichoic acid biosynthesis EQJ69_19265 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase EQJ69_19275 ENOG4107RZX Teichoic acid biosynthesis protein EQJ69_19285 ENOG4105DG6 mannose-6-phosphate isomerase EQJ69_19295 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase EQJ69_19300 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) EQJ69_19305 ENOG4108UHU Aldolase EQJ69_19310 ENOG4105D7K pfkb domain protein EQJ69_19315 ENOG4108M60 Transcriptional regulator EQJ69_19325 ENOG4105CHR reductase EQJ69_19330 ENOG4105E2A Dehydrogenase EQJ69_19335 ENOG4105C54 Major Facilitator superfamily EQJ69_19340 ENOG4108KGH TRANSCRIPTIONal EQJ69_19345 ENOG4105J7I hydrolase EQJ69_19350 ENOG4105K4H Nlp p60 protein EQJ69_19355 ENOG4105PNM synthesis protein EQJ69_19365 ENOG4105N98 Capsule biosynthesis protein capB EQJ69_19370 ENOG4105ETE Transcriptional regulator (LacI family EQJ69_19375 ENOG4108RVA ribokinase EQJ69_19380 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EQJ69_19385 ENOG4105C2J ABC transporter EQJ69_19390 ENOG4105CNN ABC, transporter EQJ69_19395 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EQJ69_19405 ENOG4107FQX Alpha-acetolactate decarboxylase EQJ69_19415 ENOG4107RSM transcriptional regulator EQJ69_19420 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EQJ69_19430 ENOG4105CAH Chromate EQJ69_19435 ENOG4105FGV Chromate EQJ69_19440 ENOG4108RB3 Capsular polysaccharide biosynthesis protein EQJ69_19445 ENOG4105HTX biosynthesis protein EQJ69_19455 ENOG4105KBK Zinc finger, swim domain protein EQJ69_19460 ENOG4105C0D helicase EQJ69_19465 ENOG410667J hydrolase EQJ69_19470 ENOG4105E98 transcriptional regulator DeoR family EQJ69_19480 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase EQJ69_19485 ENOG4105VI0 Pts system, glucitol sorbitol-specific EQJ69_19490 ENOG4105DZY Pts system, glucitol sorbitol-specific EQJ69_19495 ENOG410787A Pts system, glucitol sorbitol-specific EQJ69_19505 ENOG4105DKT Transcriptional regulator EQJ69_19510 ENOG4105Z8H single-stranded DNA-binding protein EQJ69_19530 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EQJ69_19535 ENOG4105CGA flagellar basal-body rod protein FlgG EQJ69_19545 ENOG4105DFF Rod shape-determining protein mreb EQJ69_19550 ENOG4105MT0 Sporulation transcriptional regulator spoiiid EQJ69_19560 ENOG4107MII Sugar-specific transcriptional regulator TrmB EQJ69_19565 ENOG4105CZM Major Facilitator EQJ69_19570 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EQJ69_19575 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase EQJ69_19585 ENOG4108NA0 Uncharacterized conserved protein (COG2071) EQJ69_19590 ENOG41080XP Cbs domain EQJ69_19600 ENOG4105C37 (CBS) domain EQJ69_19605 ENOG4105BZU Histidine kinase EQJ69_19625 ENOG4105FRN stage II sporulation protein EQJ69_19630 ENOG4107TCE N-acetyltransferase EQJ69_19640 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EQJ69_19645 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQJ69_19650 ENOG4105WQT MbtH domain protein EQJ69_19655 ENOG4105CEY Amp-dependent synthetase and ligase EQJ69_19660 ENOG4105WQI isochorismatase EQJ69_19665 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EQJ69_19670 ENOG4105E4F Isochorismate synthase EQJ69_19675 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EQJ69_19680 ENOG4105NIV Esterase EQJ69_19700 ENOG410874W AraC family transcriptional regulator EQJ69_19710 ENOG4108RYK Nad-dependent epimerase dehydratase EQJ69_19715 ENOG4108Z40 Transcriptional regulator EQJ69_19730 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EQJ69_19735 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EQJ69_19740 ENOG4105FCD Major Facilitator EQJ69_19745 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EQJ69_19750 ENOG4108TF4 von Willebrand factor, type A EQJ69_19765 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EQJ69_19775 ENOG4106778 Protein of unknown function (DUF1146) EQJ69_19780 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EQJ69_19785 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EQJ69_19790 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EQJ69_19795 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EQJ69_19800 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EQJ69_19815 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) EQJ69_19830 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EQJ69_19835 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EQJ69_19840 ENOG4108UIC UPF0340 protein EQJ69_19845 ENOG4108YZG isomerase EQJ69_19850 ENOG4107WAU Protein tyrosine phosphatase EQJ69_19855 ENOG410815N Probably functions as a manganese efflux pump (By similarity) EQJ69_19860 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EQJ69_19870 ENOG4108ZXQ stage ii sporulation protein r EQJ69_19885 ENOG4105TRI Hydrolase EQJ69_19900 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EQJ69_19905 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EQJ69_19910 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EQJ69_19920 ENOG4107TT2 Auxin Efflux Carrier EQJ69_19925 ENOG4105C6K Malic enzyme EQJ69_19930 ENOG4107104 thymidine kinase EQJ69_19935 ENOG41082DI 50s ribosomal protein l31 EQJ69_19940 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EQJ69_19945 ENOG4105CBT Fructose-1,6-bisphosphatase EQJ69_19950 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EQJ69_19955 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway EQJ69_19960 ENOG4105D2N Aldolase EQJ69_19965 ENOG410812K response regulator receiver protein EQJ69_19975 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EQJ69_19985 ENOG4105C1G acyl-Coa dehydrogenase EQJ69_19990 ENOG4105C1G acyl-Coa dehydrogenase EQJ69_19995 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EQJ69_20005 ENOG4105DF6 Fe-S oxidoreductase EQJ69_20020 ENOG4105C75 arginyL-tRNA synthetase EQJ69_20025 ENOG410684U Domain of unknown function (DUF1934) EQJ69_20030 ENOG4105CYW agmatinase EQJ69_20035 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EQJ69_20050 ENOG4105BZ4 penicillin-binding protein EQJ69_20055 ENOG4108XFG YwhD family EQJ69_20060 ENOG4108Z4T Peptidase M50 EQJ69_20065 ENOG41069HH 4-oxalocrotonate tautomerase EQJ69_20080 ENOG4105DCI Phosphohydrolase EQJ69_20090 ENOG4108VCI transcription factor, rsfa family EQJ69_20100 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) EQJ69_20110 ENOG4105D2S major facilitator superfamily EQJ69_20135 ENOG4108FUF Transcriptional regulator, IclR family EQJ69_20145 ENOG4108IJ2 phosphate acetyltransferase EQJ69_20150 ENOG4107JTW chlorite dismutase EQJ69_20165 ENOG4105CZN Potassium uptake protein EQJ69_20185 ENOG4105CJ1 ABC, transporter EQJ69_20215 ENOG4105C26 Dehydrogenase EQJ69_20220 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EQJ69_20225 ENOG4108RJ9 Glycosyl transferase, family 2 EQJ69_20230 ENOG4105DWF phosphomethylpyrimidine kinase EQJ69_20245 ENOG4105C5Y PTS System EQJ69_20260 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin EQJ69_20270 ENOG4105DEN Luciferase family EQJ69_20275 ENOG4108DBC nitroreductase EQJ69_20295 ENOG4105DWD nucleoside recognition domain protein EQJ69_20350 ENOG41060D1 Quinol oxidase EQJ69_20360 ENOG4105BZ9 Cytochrome C oxidase, subunit I EQJ69_20365 ENOG4105E2S oxidase) subunit II EQJ69_20370 ENOG4105CMR udp-glucose 4-epimerase EQJ69_20400 ENOG4105CMG Carbohydrate kinase EQJ69_20405 ENOG4105C93 Xylose Isomerase EQJ69_20415 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EQJ69_20420 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase EQJ69_20425 ENOG4105CMU LysR family (Transcriptional regulator EQJ69_20445 ENOG41067MG lrgb family EQJ69_20455 ENOG4105CK7 Sodium proline symporter EQJ69_20460 ENOG4105DR4 Methyltransferase EQJ69_20470 ENOG4105C5I Dehydrogenase EQJ69_20475 ENOG4105X1N Glycosyl transferase family 8 EQJ69_20485 ENOG4105ENE Histidine kinase EQJ69_20490 ENOG4108VB1 regulatoR EQJ69_20495 ENOG4105EYF MMPL domain protein EQJ69_20505 ENOG4105DJB Major Facilitator Superfamily EQJ69_20510 ENOG4105CXK mandelate racemase muconate lactonizing EQJ69_20515 ENOG4108UHU Aldolase EQJ69_20520 ENOG4105D7K pfkb domain protein EQJ69_20530 ENOG4105IIU Aminopeptidase EQJ69_20535 ENOG41080V3 Major Facilitator superfamily EQJ69_20560 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) EQJ69_20565 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EQJ69_20570 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) EQJ69_20575 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EQJ69_20580 ENOG4105CM2 brancheD-chain amino acid aminotransferase EQJ69_20590 ENOG4105F8D glycoside hydrolase family 4 EQJ69_20595 ENOG4105VCP PTS System EQJ69_20600 ENOG4105CK1 PTS System EQJ69_20605 ENOG4105VZJ PTS System EQJ69_20610 ENOG4105EMD TRANSCRIPTIONal EQJ69_20615 ENOG4108VX5 3-methyladenine DNA glycosylase EQJ69_20630 ENOG4105DXD 2-methylcitrate dehydratase EQJ69_20635 ENOG4105CR4 methylisocitrate lyase EQJ69_20650 ENOG4105BZ1 (ABC) transporter EQJ69_20655 ENOG4107TDE lipolytic protein G-D-S-L family EQJ69_20670 ENOG4105C2C drug resistance transporter, Bcr CflA EQJ69_20680 ENOG4105DA5 (ABC) transporter EQJ69_20685 ENOG41069JR EQJ69_20710 ENOG4105CH6 catalase EQJ69_20720 ENOG4105G5W regulator Fur family EQJ69_20725 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EQJ69_20730 ENOG4108TU7 Inherit from COG: (ABC) transporter EQJ69_20735 ENOG4105CJ1 ABC, transporter EQJ69_20750 ENOG4105CJ1 ABC, transporter EQJ69_20800 ENOG4108J20 pectate lyase EQJ69_20805 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EQJ69_20810 ENOG4108JJ8 (ABC) transporter EQJ69_20815 ENOG4108JJ9 ABC, transporter EQJ69_20820 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EQJ69_20825 ENOG4105C4M (Ubiquinol oxidase) subunit I EQJ69_20835 ENOG4108QTI )-transporter EQJ69_20850 ENOG4105DFD Na H antiporter EQJ69_20855 ENOG4108IJ0 Aspartate ammonia-lyase EQJ69_20860 ENOG4105HDK L-asparaginase EQJ69_20865 ENOG4108IMY Transcriptional regulator EQJ69_20870 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EQJ69_20910 ENOG4107BJW polysaccharide deacetylase EQJ69_20925 ENOG4107QZ7 Cellulose synthase catalytic subunit EQJ69_20930 ENOG4105D2K citrate carrier protein EQJ69_20935 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EQJ69_20940 ENOG4105X3H Excalibur domain protein EQJ69_20950 ENOG4105E0M Sulfatase EQJ69_20960 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EQJ69_20975 ENOG4105CEU Arginine dihydrolase EQJ69_20980 ENOG4105DBV ornithine carbamoyltransferase EQJ69_20990 ENOG4105C5B carbamate kinase EQJ69_21000 ENOG4105CS2 ec 3.2.1.21 EQJ69_21005 ENOG4105CK1 PTS System EQJ69_21015 ENOG4105JVQ RNA Polymerase EQJ69_21040 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EQJ69_21045 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EQJ69_21055 ENOG4107R3K hydrolase EQJ69_21060 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) EQJ69_21065 ENOG4105DRS transport system, permease EQJ69_21070 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EQJ69_21080 ENOG4105ETE Transcriptional regulator (LacI family EQJ69_21100 ENOG4105EDW glycosyl transferase, family 39 EQJ69_21105 ENOG4105CKK Glycosyl transferase, family 2 EQJ69_21110 ENOG4105CMR udp-glucose 4-epimerase EQJ69_21150 ENOG4105CS2 ec 3.2.1.21 EQJ69_21155 ENOG4105C5Y PTS System EQJ69_21160 ENOG4105CID antiterminator EQJ69_21170 ENOG4108JJB ABC transporter EQJ69_21175 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein EQJ69_21180 ENOG4105ETU transcriptional activator (TenA EQJ69_21190 ENOG4107QP3 malate synthase g EQJ69_21200 ENOG4105EDW glycosyl transferase, family 39 EQJ69_21210 ENOG4105C19 ABC transporter EQJ69_21215 ENOG4105EWM Histidine kinase EQJ69_21225 ENOG4105CS2 ec 3.2.1.21 EQJ69_21230 ENOG4105C5Y PTS System EQJ69_21240 ENOG4107QHE Choloylglycine hydrolase EQJ69_21255 ENOG4106Z5D Glycoside Hydrolase Family 43 EQJ69_21260 ENOG4105C1J atp-dependent rna helicase EQJ69_21290 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EQJ69_21295 ENOG4105D9N nucleoside EQJ69_21300 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EQJ69_21305 ENOG4107RHR regulatoR EQJ69_21325 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) EQJ69_21330 ENOG4107R8N Glycosyl transferase, family 2 EQJ69_21340 ENOG4105JKW Valine--pyruvate aminotransferase EQJ69_21365 ENOG4105D2N Aldolase EQJ69_21370 ENOG4107TRN Xylose isomerase domain protein TIM barrel EQJ69_21375 ENOG4105F0H myo-inositol catabolism protein EQJ69_21380 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EQJ69_21390 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EQJ69_21395 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) EQJ69_21400 ENOG4105D7K pfkb domain protein EQJ69_21405 ENOG4105DH8 myo-inositol catabolism EQJ69_21410 ENOG4105C26 Dehydrogenase EQJ69_21420 ENOG4105CPC Aldo Keto reductase EQJ69_21430 ENOG4105CXY transporter EQJ69_21435 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EQJ69_21440 ENOG4105C5H ABC transporter EQJ69_21445 ENOG410667J hydrolase EQJ69_21455 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) EQJ69_21465 ENOG4108V5C ABC transporter EQJ69_21495 ENOG4105H93 Acyltransferase family EQJ69_21525 ENOG4105EC8 Methyl-accepting chemotaxis EQJ69_21530 ENOG4105BZG amino acid carrier protein EQJ69_21535 ENOG4105DCF alanine dehydrogenase EQJ69_21550 ENOG4105EG2 ABC transporter, permease EQJ69_21560 ENOG4107FKK extracellular solute-binding protein family 1 EQJ69_21570 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) EQJ69_21575 ENOG4105CMR udp-glucose 4-epimerase EQJ69_21580 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase EQJ69_21585 ENOG4105E2R ROK family EQJ69_21595 ENOG4105CMG Carbohydrate kinase EQJ69_21610 ENOG4108EKI Dehydrogenase EQJ69_21615 ENOG4105D3R alkyl hydroperoxide reductase EQJ69_21620 ENOG4108JU3 Alkyl hydroperoxide reductase EQJ69_21645 ENOG4108M15 ABC transporter EQJ69_21650 ENOG4105KCT ABC transporter EQJ69_21685 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EQJ69_21700 ENOG4105WQG acetyltransferase EQJ69_21715 ENOG4105C0H protease EQJ69_21720 ENOG4105Q2H domain protein EQJ69_21735 ENOG4105BZU Histidine kinase EQJ69_21740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQJ69_21770 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EQJ69_21780 ENOG4105CDU Replicative dna helicase EQJ69_21800 ENOG4105DJ2 Major Facilitator Superfamily EQJ69_21805 ENOG4105CE4 GlcNAc 6-P deacetylase EQJ69_21810 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EQJ69_21815 ENOG4105FDP GntR family transcriptional regulator EQJ69_21820 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EQJ69_21830 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EQJ69_21835 ENOG4105BZR domain protein EQJ69_21840 ENOG4108XMW Membrane EQJ69_21855 ENOG4105CHH sulfate transporter EQJ69_21865 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EQJ69_21870 ENOG4108UUM single-stranded DNA-binding protein EQJ69_21875 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EQJ69_21880 ENOG4105C3G gtp-binding protein EQJ69_21890 ENOG4105VDK protein, conserved in bacteria EQJ69_21900 ENOG4108ZDA Sporulation protein YyaC EQJ69_21905 ENOG4105FA0 parb-like partition protein EQJ69_21910 ENOG4107QJE Chromosome Partitioning Protein EQJ69_21915 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EQJ69_21925 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) EQJ69_21935 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EQJ69_21940 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EQJ69_21955 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EQJ69_22045 ENOG4105K4H Nlp p60 protein EQJ69_22175 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EQJ69_22220 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQJ69_22225 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQJ69_22230 ENOG4105U6W MutT NUDIX family protein EQJ69_22250 ENOG4108UK2 deaminase EQJ69_22260 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQJ69_22285 ENOG4105C0B DNA polymerase III (alpha subunit) EQJ69_22310 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EQJ69_22350 ENOG4105DUM transcriptional regulator, lysR family EQJ69_22410 ENOG4105I03 Flagellin EQJ69_22445 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EQJ69_22495 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EQJ69_22505 ENOG4105C4R Atp-dependent dna helicase EQJ69_22680 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EQJ69_22710 ENOG41069ER domain protein EQJ69_22720 ENOG4105C7H Helicase, RecD TraA family EQJ69_23125 ENOG4105KRN Transcriptional regulator, abrb family EQJ69_23165 ENOG4108UUM single-stranded DNA-binding protein