locus-tag	class	description
D5E69_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5E69_00010	COG0592	DNA-directed DNA polymerase activity
D5E69_00015	COG2501	S4 domain
D5E69_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5E69_00030	COG0187	DNA topoisomerase II activity
D5E69_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D5E69_00070	COG0386	Belongs to the glutathione peroxidase family
D5E69_00080	COG0516	GMP reductase activity
D5E69_00080	COG0517	IMP dehydrogenase activity
D5E69_00095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D5E69_00125	COG1428	Deoxynucleoside kinase
D5E69_00130	COG1428	Deoxynucleoside kinase
D5E69_00140	COG1335	isochorismatase
D5E69_00145	COG0590	tRNA wobble adenosine to inosine editing
D5E69_00160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D5E69_00165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D5E69_00220	COG1982	Orn Lys Arg decarboxylase major
D5E69_00225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D5E69_00230	COG3870	Protein conserved in bacteria
D5E69_00235	COG1728	Protein conserved in bacteria
D5E69_00240	COG0470	DNA polymerase III
D5E69_00245	COG1774	PSP1 C-terminal conserved region
D5E69_00250	COG4467	Involved in initiation control of chromosome replication
D5E69_00255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D5E69_00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D5E69_00265	COG2002	toxin-antitoxin pair type II binding
D5E69_00275	COG0084	hydrolase, TatD family'
D5E69_00300	COG4466	Protein conserved in bacteria
D5E69_00310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D5E69_00315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5E69_00320	COG0251	oxidation-reduction process
D5E69_00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D5E69_00345	COG0193	aminoacyl-tRNA hydrolase activity
D5E69_00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D5E69_00360	COG2002	toxin-antitoxin pair type II binding
D5E69_00365	COG2244	polysaccharide biosynthetic process
D5E69_00370	COG3956	TIGRFAM MazG family protein
D5E69_00375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D5E69_00390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D5E69_00395	COG1098	S1 RNA binding domain
D5E69_00410	COG2208	phosphoserine phosphatase activity
D5E69_00415	COG2304	oxidoreductase activity
D5E69_00420	COG0515	serine threonine protein kinase
D5E69_00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5E69_00445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D5E69_00450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5E69_00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5E69_00460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D5E69_00465	COG0512	Glutamine amidotransferase of anthranilate synthase
D5E69_00470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5E69_00475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D5E69_00480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D5E69_00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5E69_00490	COG1396	sequence-specific DNA binding
D5E69_00580	COG3880	PFAM UvrB UvrC protein
D5E69_00585	COG3869	Catalyzes the specific phosphorylation of arginine residues in
D5E69_00590	COG0542	response to heat
D5E69_00595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D5E69_00605	COG4956	integral membrane protein (PIN domain superfamily)
D5E69_00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D5E69_00620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5E69_00625	COG1045	serine acetyltransferase
D5E69_00630	COG0215	cysteine-tRNA ligase activity
D5E69_00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5E69_00645	COG3688	RNA-binding protein containing a PIN domain
D5E69_00660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D5E69_00665	COG0250	Participates in transcription elongation, termination and antitermination
D5E69_00675	COG0081	regulation of translation
D5E69_00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D5E69_00690	COG2813	Specifically methylates the guanine in position
D5E69_00705	COG1358	cellular component organization or biogenesis
D5E69_00715	COG0049	tRNA binding
D5E69_00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D5E69_00730	COG0051	transcription antitermination factor activity, RNA binding
D5E69_00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D5E69_00740	COG0088	Forms part of the polypeptide exit tunnel
D5E69_00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D5E69_00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D5E69_00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D5E69_00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D5E69_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
D5E69_00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D5E69_00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D5E69_00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D5E69_00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5E69_00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D5E69_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D5E69_00825	COG1841	ribosomal large subunit assembly
D5E69_00835	COG0201	protein transport
D5E69_00840	COG0563	adenylate kinase activity
D5E69_00845	COG0024	Methionine aminopeptidase
D5E69_00850	COG2163	COG2163 Ribosomal protein L14E L6E L27E
D5E69_00855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D5E69_00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D5E69_00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5E69_00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D5E69_00875	COG0202	RNA polymerase activity
D5E69_00880	COG0203	ribosomal protein L17
D5E69_00885	COG1122	ATPase activity
D5E69_00890	COG1122	ATPase activity
D5E69_00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D5E69_00900	COG0101	tRNA pseudouridine synthase activity
D5E69_00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D5E69_00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D5E69_00920	COG4282	regulation of fungal-type cell wall biogenesis
D5E69_00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_00935	COG0489	protein tyrosine kinase activity
D5E69_00945	COG2194	sulfuric ester hydrolase activity
D5E69_00950	COG0726	polysaccharide deacetylase
D5E69_01025	COG1595	DNA-templated transcription, initiation
D5E69_01030	COG5662	AntiSigma factor
D5E69_01035	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D5E69_01040	COG4856	YbbR-like protein
D5E69_01045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5E69_01050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D5E69_01060	COG2226	methyltransferase
D5E69_01070	COG0346	lactoylglutathione lyase activity
D5E69_01090	COG0726	polysaccharide deacetylase
D5E69_01100	COG0745	RESPONSE REGULATOR receiver
D5E69_01105	COG5002	protein histidine kinase activity
D5E69_01120	COG0346	lactoylglutathione lyase activity
D5E69_01125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5E69_01135	COG1733	regulation of RNA biosynthetic process
D5E69_01140	COG2814	Major facilitator Superfamily
D5E69_01165	COG1510	regulation of RNA biosynthetic process
D5E69_01170	COG4175	Glycine betaine
D5E69_01170	COG0517	IMP dehydrogenase activity
D5E69_01175	COG4176	ABC-type proline glycine betaine transport system permease component
D5E69_01180	COG2113	Glycine betaine
D5E69_01185	COG0454	-acetyltransferase
D5E69_01195	COG0840	transmembrane signaling receptor activity
D5E69_01205	COG0577	efflux transmembrane transporter activity
D5E69_01210	COG0577	efflux transmembrane transporter activity
D5E69_01210	COG1136	(ABC) transporter
D5E69_01220	COG5002	protein histidine kinase activity
D5E69_01235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5E69_01240	COG1116	anion transmembrane transporter activity
D5E69_01245	COG1940	carbohydrate kinase activity
D5E69_01250	COG0800	Aldolase
D5E69_01260	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D5E69_01270	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_01275	COG1414	Transcriptional regulator
D5E69_01290	COG1175	transmembrane transport
D5E69_01295	COG0395	ABC-type sugar transport system, permease component
D5E69_01300	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D5E69_01305	COG1609	Transcriptional regulator
D5E69_01310	COG0673	inositol 2-dehydrogenase activity
D5E69_01325	COG3962	Belongs to the TPP enzyme family
D5E69_01330	COG1082	Xylose isomerase domain protein TIM barrel
D5E69_01390	COG0601	transmembrane transport
D5E69_01395	COG2861	carbohydrate metabolic process
D5E69_01400	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_01405	COG1757	Na H antiporter
D5E69_01425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5E69_01430	COG4585	Histidine kinase
D5E69_01435	COG2197	response regulator
D5E69_01440	COG1131	(ABC) transporter
D5E69_01470	COG1597	lipid kinase activity
D5E69_01475	COG1238	metal cluster binding
D5E69_01480	COG0018	arginyl-trna synthetase
D5E69_01485	COG0772	Belongs to the SEDS family
D5E69_01490	COG1253	flavin adenine dinucleotide binding
D5E69_01500	COG1489	DNA binding
D5E69_01510	COG4134	Bacterial extracellular solute-binding protein
D5E69_01525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D5E69_01530	COG0398	Pfam SNARE associated Golgi protein
D5E69_01560	COG1181	Belongs to the D-alanine--D-alanine ligase family
D5E69_01565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D5E69_01575	COG0513	Belongs to the DEAD box helicase family
D5E69_01580	COG4294	response to UV
D5E69_01585	COG3402	PFAM membrane-flanked domain
D5E69_01590	COG3428	Bacterial PH domain
D5E69_01595	COG0705	Rhomboid family
D5E69_01600	COG0736	holo-[acyl-carrier-protein] synthase activity
D5E69_01620	COG2337	Toxic component of a toxin-antitoxin (TA) module
D5E69_01655	COG1191	sigma factor activity
D5E69_01660	COG2208	phosphoserine phosphatase activity
D5E69_01665	COG2183	response to ionizing radiation
D5E69_01675	COG3091	SprT-like family
D5E69_01760	COG0802	atpase or kinase
D5E69_01765	COG1214	PFAM Peptidase M22, glycoprotease
D5E69_01770	COG0456	acetyltransferase
D5E69_01780	COG0488	(ABC) transporter
D5E69_01785	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D5E69_01790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5E69_01795	COG0805	protein transport
D5E69_01805	COG1266	CAAX protease self-immunity
D5E69_01810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5E69_01815	COG0459	protein refolding
D5E69_01820	COG1940	carbohydrate kinase activity
D5E69_01835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_01840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_01840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_01840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_01850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5E69_01855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D5E69_01870	COG4174	ABC transporter (Permease)
D5E69_01880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D5E69_01885	COG3773	Cell wall hydrolase
D5E69_01890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_01895	COG0673	inositol 2-dehydrogenase activity
D5E69_01905	COG0673	inositol 2-dehydrogenase activity
D5E69_01910	COG2226	methyltransferase
D5E69_01915	COG5001	Diguanylate cyclase
D5E69_01915	COG3300	MHYT domain
D5E69_01930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D5E69_01940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D5E69_01945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D5E69_01955	COG0714	Associated with various cellular activities
D5E69_01960	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D5E69_01970	COG1305	Transglutaminase-like
D5E69_01980	COG2252	PERMEase
D5E69_01985	COG3711	transcriptional antiterminator
D5E69_02010	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
D5E69_02020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D5E69_02025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D5E69_02030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D5E69_02040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D5E69_02045	COG0047	phosphoribosylformylglycinamidine synthase activity
D5E69_02050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D5E69_02055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D5E69_02065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D5E69_02075	COG0151	Belongs to the GarS family
D5E69_02090	COG1470	cell adhesion involved in biofilm formation
D5E69_02095	COG4496	protein, YerC YecD
D5E69_02100	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D5E69_02105	COG0210	DNA helicase
D5E69_02115	COG4851	CamS sex pheromone cAM373 precursor
D5E69_02120	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D5E69_02125	COG2224	Isocitrate lyase
D5E69_02130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D5E69_02135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D5E69_02140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D5E69_02150	COG0505	Belongs to the CarA family
D5E69_02155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D5E69_02160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5E69_02165	COG5506	Protein of unknown function (DUF1694)
D5E69_02180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5E69_02185	COG0154	amidase activity
D5E69_02220	COG1597	lipid kinase activity
D5E69_02245	COG0166	Belongs to the GPI family
D5E69_02250	COG4895	conserved protein (DUF2196)
D5E69_02255	COG1984	allophanate hydrolase subunit 2
D5E69_02260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D5E69_02265	COG2814	Major facilitator Superfamily
D5E69_02280	COG1366	Belongs to the anti-sigma-factor antagonist family
D5E69_02285	COG1131	(ABC) transporter
D5E69_02315	COG2966	Psort location CytoplasmicMembrane, score
D5E69_02320	COG3610	response to peptide
D5E69_02335	COG1132	(ABC) transporter
D5E69_02340	COG3871	stress protein (general stress protein 26)
D5E69_02380	COG2364	Membrane
D5E69_02385	COG1199	ATP-dependent helicase activity
D5E69_02390	COG2193	ferroxidase activity
D5E69_02405	COG1404	Belongs to the peptidase S8 family
D5E69_02410	COG2032	superoxide dismutase activity
D5E69_02415	COG0733	neurotransmitter:sodium symporter activity
D5E69_02420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5E69_02425	COG0488	(ABC) transporter
D5E69_02430	COG1609	Transcriptional regulator
D5E69_02435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5E69_02440	COG1869	D-ribose catabolic process
D5E69_02445	COG1129	ABC transporter
D5E69_02450	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5E69_02455	COG1879	ABC-type sugar transport system periplasmic component
D5E69_02465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_02470	COG1846	Transcriptional regulator
D5E69_02475	COG0477	Major facilitator Superfamily
D5E69_02485	COG3396	Phenylacetate-CoA oxygenase
D5E69_02500	COG2151	metal-sulfur cluster biosynthetic enzyme
D5E69_02515	COG1024	Enoyl-CoA hydratase
D5E69_02520	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_02525	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5E69_02530	COG0183	Belongs to the thiolase family
D5E69_02540	COG3327	negative regulation of DNA-templated transcription, initiation
D5E69_02565	COG4120	Belongs to the binding-protein-dependent transport system permease family
D5E69_02570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5E69_02610	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D5E69_02615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5E69_02635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5E69_02640	COG0129	dihydroxy-acid dehydratase activity
D5E69_02645	COG0028	Belongs to the TPP enzyme family
D5E69_02650	COG0440	acetolactate synthase activity
D5E69_02655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D5E69_02660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5E69_02670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5E69_02675	COG0066	3-isopropylmalate dehydratase activity
D5E69_02685	COG0460	homoserine dehydrogenase
D5E69_02690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D5E69_02695	COG0083	homoserine kinase activity
D5E69_02705	COG3852	Histidine kinase
D5E69_02720	COG4106	trans-aconitate 2-methyltransferase activity
D5E69_02750	COG1957	nucleoside hydrolase
D5E69_02755	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5E69_02765	COG3842	ATPase activity
D5E69_02770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D5E69_02775	COG1737	Transcriptional regulator
D5E69_02780	COG1070	Carbohydrate kinase
D5E69_02790	COG0702	epimerase
D5E69_02795	COG1309	transcriptional regulator
D5E69_02800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5E69_02805	COG2244	polysaccharide biosynthetic process
D5E69_02850	COG2197	response regulator
D5E69_02870	COG0714	Associated with various cellular activities
D5E69_02885	COG1714	RDD family
D5E69_02900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_02900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_02900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_02905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_02910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_02915	COG0383	alpha-mannosidase activity
D5E69_02920	COG3711	transcriptional antiterminator
D5E69_02920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_02925	COG0456	acetyltransferase
D5E69_02935	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_02945	COG2130	NADP-dependent
D5E69_02965	COG0288	reversible hydration of carbon dioxide
D5E69_02990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_03000	COG0488	(ABC) transporter
D5E69_03015	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D5E69_03030	COG1595	DNA-templated transcription, initiation
D5E69_03035	COG1077	Cell shape determining protein MreB Mrl
D5E69_03040	COG0840	transmembrane signaling receptor activity
D5E69_03050	COG1607	acyl-coa hydrolase
D5E69_03070	COG2267	carboxylic ester hydrolase activity
D5E69_03080	COG2309	aminopeptidase activity
D5E69_03085	COG1959	2 iron, 2 sulfur cluster binding
D5E69_03105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5E69_03110	COG1360	Flagellar Motor Protein
D5E69_03125	COG1115	amino acid carrier protein
D5E69_03130	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_03135	COG4605	iron ion homeostasis
D5E69_03140	COG4604	ABC transporter, ATP-binding protein
D5E69_03145	COG4607	ABC-type enterochelin transport system periplasmic component
D5E69_03150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5E69_03155	COG2313	pseudouridylate synthase activity
D5E69_03160	COG5002	protein histidine kinase activity
D5E69_03175	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D5E69_03180	COG0693	protein deglycase activity
D5E69_03195	COG1295	ribonuclease BN
D5E69_03200	COG1966	Carbon starvation protein
D5E69_03215	COG5578	integral membrane protein
D5E69_03220	COG1653	transport
D5E69_03230	COG0395	ABC-type sugar transport system, permease component
D5E69_03255	COG1063	alcohol dehydrogenase
D5E69_03260	COG0673	inositol 2-dehydrogenase activity
D5E69_03265	COG0673	inositol 2-dehydrogenase activity
D5E69_03295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5E69_03305	COG1309	transcriptional regulator
D5E69_03320	COG1126	abc transporter atp-binding protein
D5E69_03345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_03345	COG2190	(PTS) system
D5E69_03345	COG1263	PTS System
D5E69_03360	COG4208	sulfate ABC transporter
D5E69_03370	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D5E69_03380	COG2217	Heavy metal translocating P-type atpase
D5E69_03385	COG0477	Major facilitator Superfamily
D5E69_03450	COG1131	(ABC) transporter
D5E69_03460	COG0387	Pfam Sodium calcium exchanger
D5E69_03480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_03485	COG0535	radical SAM domain protein
D5E69_03505	COG2323	membrane
D5E69_03535	COG2226	methyltransferase
D5E69_03540	COG2210	Belongs to the sulfur carrier protein TusA family
D5E69_03550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5E69_03550	COG0425	Belongs to the sulfur carrier protein TusA family
D5E69_03555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5E69_03555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_03560	COG0425	Belongs to the sulfur carrier protein TusA family
D5E69_03580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5E69_03605	COG1131	(ABC) transporter
D5E69_03620	COG0561	phosphatase activity
D5E69_03635	COG0531	amino acid
D5E69_03645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_03650	COG1575	Belongs to the MenA family. Type 1 subfamily
D5E69_03670	COG1335	isochorismatase
D5E69_03675	COG1522	sequence-specific DNA binding
D5E69_03700	COG1979	alcohol dehydrogenase
D5E69_03705	COG1683	Conserved Protein
D5E69_03715	COG1473	amidohydrolase
D5E69_03745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_03770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D5E69_03775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5E69_03800	COG0494	nUDIX hydrolase
D5E69_03815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5E69_03820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5E69_03835	COG0588	phosphoglycerate mutase activity
D5E69_03860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5E69_03870	COG0456	acetyltransferase
D5E69_03930	COG1175	transmembrane transport
D5E69_03935	COG0395	ABC-type sugar transport system, permease component
D5E69_03955	COG2910	NAD(P)H-binding
D5E69_03960	COG1959	2 iron, 2 sulfur cluster binding
D5E69_03965	COG2814	Major facilitator Superfamily
D5E69_03970	COG0640	Transcriptional regulator
D5E69_03980	COG1840	ABC-type Fe3 transport system, periplasmic component
D5E69_03985	COG1178	ABC-type Fe3 transport system permease component
D5E69_03990	COG3842	ATPase activity
D5E69_03995	COG0456	acetyltransferase
D5E69_04005	COG2808	Putative FMN-binding domain
D5E69_04010	COG1388	LysM domain
D5E69_04020	COG1595	DNA-templated transcription, initiation
D5E69_04035	COG1454	alcohol dehydrogenase
D5E69_04055	COG0456	acetyltransferase
D5E69_04080	COG1609	Transcriptional regulator
D5E69_04085	COG0561	phosphatase activity
D5E69_04100	COG0210	DNA helicase
D5E69_04145	COG2318	DinB family
D5E69_04155	COG1846	Transcriptional regulator
D5E69_04165	COG0789	Transcriptional regulator
D5E69_04170	COG1064	alcohol dehydrogenase
D5E69_04190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5E69_04195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5E69_04215	COG0406	alpha-ribazole phosphatase activity
D5E69_04220	COG0110	maltose O-acetyltransferase activity
D5E69_04225	COG3420	alginic acid biosynthetic process
D5E69_04240	COG1280	lysine exporter protein (LysE YggA)
D5E69_04250	COG1136	(ABC) transporter
D5E69_04290	COG0583	DNA-binding transcription factor activity
D5E69_04295	COG0778	Nitroreductase
D5E69_04325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_04345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D5E69_04350	COG1595	DNA-templated transcription, initiation
D5E69_04360	COG2318	DinB family
D5E69_04375	COG2169	Transcriptional regulator
D5E69_04380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D5E69_04385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5E69_04405	COG3708	Transcriptional regulator
D5E69_04405	COG2207	Transcriptional regulator
D5E69_04415	COG0583	DNA-binding transcription factor activity
D5E69_04420	COG2267	carboxylic ester hydrolase activity
D5E69_04440	COG2267	carboxylic ester hydrolase activity
D5E69_04460	COG1733	regulation of RNA biosynthetic process
D5E69_04470	COG2367	Beta-lactamase
D5E69_04500	COG2076	Multidrug Resistance protein
D5E69_04505	COG2076	Multidrug Resistance protein
D5E69_04510	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D5E69_04515	COG5002	protein histidine kinase activity
D5E69_04520	COG0745	RESPONSE REGULATOR receiver
D5E69_04530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5E69_04535	COG1696	Membrane protein involved in D-alanine export
D5E69_04540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5E69_04545	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D5E69_04565	COG1253	flavin adenine dinucleotide binding
D5E69_04570	COG1253	flavin adenine dinucleotide binding
D5E69_04615	COG1595	DNA-templated transcription, initiation
D5E69_04635	COG1840	ABC-type Fe3 transport system, periplasmic component
D5E69_04640	COG3842	ATPase activity
D5E69_04665	COG2376	Dihydroxyacetone kinase
D5E69_04680	COG5444	nuclease activity
D5E69_04710	COG2801	Transposase and inactivated derivatives
D5E69_04725	COG0300	oxidoreductase activity
D5E69_04735	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_04755	COG1104	cysteine desulfurase activity
D5E69_04810	COG5505	Protein of unknown function (DUF819)
D5E69_04885	COG1316	TRANSCRIPTIONal
D5E69_04895	COG5002	protein histidine kinase activity
D5E69_04900	COG0745	RESPONSE REGULATOR receiver
D5E69_04950	COG0305	Participates in initiation and elongation during chromosome replication
D5E69_04980	COG3655	Transcriptional regulator
D5E69_05005	COG0789	Transcriptional regulator
D5E69_05030	COG1131	(ABC) transporter
D5E69_05055	COG0165	Argininosuccinate lyase
D5E69_05065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5E69_05075	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_05080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5E69_05085	COG2197	response regulator
D5E69_05095	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_05100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5E69_05110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_05120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_05180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D5E69_05215	COG5002	protein histidine kinase activity
D5E69_05220	COG0456	acetyltransferase
D5E69_05220	COG0454	-acetyltransferase
D5E69_05225	COG1378	Sugar-specific transcriptional regulator TrmB
D5E69_05230	COG1280	lysine exporter protein (LysE YggA)
D5E69_05285	COG1464	Belongs to the NlpA lipoprotein family
D5E69_05290	COG2011	ABC-type metal ion transport system permease component
D5E69_05295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5E69_05300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_05350	COG1063	alcohol dehydrogenase
D5E69_05360	COG1695	Transcriptional regulator
D5E69_05390	COG1396	sequence-specific DNA binding
D5E69_05405	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_05410	COG0840	transmembrane signaling receptor activity
D5E69_05420	COG4213	ABC transporter substrate-binding protein
D5E69_05430	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5E69_05440	COG2972	Histidine kinase
D5E69_05445	COG2207	Transcriptional regulator
D5E69_05445	COG4753	response regulator
D5E69_05450	COG4213	ABC transporter substrate-binding protein
D5E69_05470	COG4224	UPF0291 protein
D5E69_05475	COG0577	efflux transmembrane transporter activity
D5E69_05490	COG0840	transmembrane signaling receptor activity
D5E69_05495	COG2226	methyltransferase
D5E69_05545	COG1070	Carbohydrate kinase
D5E69_05550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5E69_05555	COG2207	Transcriptional regulator
D5E69_05560	COG0395	ABC-type sugar transport system, permease component
D5E69_05565	COG4209	transmembrane transport
D5E69_05570	COG5578	integral membrane protein
D5E69_05575	COG1653	transport
D5E69_05580	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D5E69_05590	COG1073	alpha beta
D5E69_05620	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D5E69_05635	COG1279	arginine transmembrane transporter activity
D5E69_05640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5E69_05650	COG3850	Histidine kinase
D5E69_05650	COG5002	protein histidine kinase activity
D5E69_05670	COG0346	lactoylglutathione lyase activity
D5E69_05680	COG1131	(ABC) transporter
D5E69_05735	COG0592	DNA-directed DNA polymerase activity
D5E69_05760	COG0596	Alpha beta hydrolase
D5E69_05760	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5E69_05785	COG1408	metallophosphoesterase
D5E69_05830	COG1051	belongs to the nudix hydrolase family
D5E69_05855	COG0656	L-ascorbic acid biosynthetic process
D5E69_05875	COG0384	phenazine biosynthesis protein PhzF
D5E69_05880	COG0346	lactoylglutathione lyase activity
D5E69_05895	COG1794	racemase activity, acting on amino acids and derivatives
D5E69_05900	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_05915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5E69_05930	COG1309	transcriptional regulator
D5E69_05935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_05945	COG1609	Transcriptional regulator
D5E69_05950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5E69_05955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5E69_05965	COG1063	alcohol dehydrogenase
D5E69_05980	COG2213	PTS system mannitol-specific
D5E69_05980	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_05985	COG3711	transcriptional antiterminator
D5E69_05990	COG0246	Mannitol dehydrogenase
D5E69_06010	COG0640	Transcriptional regulator
D5E69_06030	COG1136	(ABC) transporter
D5E69_06070	COG2217	Heavy metal translocating P-type atpase
D5E69_06075	COG2608	mercury ion transmembrane transporter activity
D5E69_06080	COG1937	Protein conserved in bacteria
D5E69_06090	COG1280	lysine exporter protein (LysE YggA)
D5E69_06095	COG1051	belongs to the nudix hydrolase family
D5E69_06100	COG1368	sulfuric ester hydrolase activity
D5E69_06110	COG0596	Alpha beta hydrolase
D5E69_06115	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D5E69_06120	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D5E69_06125	COG1733	regulation of RNA biosynthetic process
D5E69_06130	COG1253	flavin adenine dinucleotide binding
D5E69_06140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5E69_06160	COG5002	protein histidine kinase activity
D5E69_06175	COG1477	protein flavinylation
D5E69_06185	COG1132	(ABC) transporter
D5E69_06190	COG1132	(ABC) transporter
D5E69_06200	COG0662	Cupin 2, conserved barrel domain protein
D5E69_06205	COG2814	Major facilitator Superfamily
D5E69_06240	COG2828	Protein conserved in bacteria
D5E69_06245	COG0583	DNA-binding transcription factor activity
D5E69_06250	COG2851	Citrate transporter
D5E69_06260	COG0583	DNA-binding transcription factor activity
D5E69_06265	COG0730	response to heat
D5E69_06275	COG0586	Pfam SNARE associated Golgi protein
D5E69_06280	COG1846	Transcriptional regulator
D5E69_06285	COG2814	Major facilitator Superfamily
D5E69_06320	COG3290	protein histidine kinase activity
D5E69_06325	COG4565	transcriptional regulatory protein
D5E69_06360	COG2153	protein acetylation
D5E69_06365	COG0300	oxidoreductase activity
D5E69_06400	COG1131	(ABC) transporter
D5E69_06405	COG4152	abc transporter atp-binding protein
D5E69_06420	COG1164	Oligoendopeptidase f
D5E69_06425	COG2267	carboxylic ester hydrolase activity
D5E69_06440	COG1247	-acetyltransferase
D5E69_06450	COG2323	membrane
D5E69_06465	COG0412	Dienelactone hydrolase
D5E69_06510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5E69_06520	COG2267	carboxylic ester hydrolase activity
D5E69_06525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5E69_06530	COG0456	acetyltransferase
D5E69_06555	COG1131	(ABC) transporter
D5E69_06590	COG0501	Belongs to the peptidase M48B family
D5E69_06595	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D5E69_06600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D5E69_06605	COG0352	thiamine-phosphate diphosphorylase activity
D5E69_06610	COG0582	viral genome integration into host DNA
D5E69_06625	COG2111	Na H antiporter
D5E69_06635	COG0651	ATP synthesis coupled electron transport
D5E69_06640	COG1863	multisubunit Na H antiporter MnhE subunit
D5E69_06645	COG2212	antiporter activity
D5E69_06650	COG1320	monovalent cation:proton antiporter activity
D5E69_06665	COG0833	amino acid
D5E69_06670	COG2040	homocysteine
D5E69_06675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5E69_06685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5E69_06695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_06705	COG1476	TRANSCRIPTIONal
D5E69_06715	COG3239	Fatty acid desaturase
D5E69_06720	COG2197	response regulator
D5E69_06725	COG1609	Transcriptional regulator
D5E69_06735	COG1621	beta-fructofuranosidase activity
D5E69_06740	COG0306	phosphate transporter
D5E69_06745	COG1392	Phosphate transport regulator
D5E69_06750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5E69_06760	COG5444	nuclease activity
D5E69_06800	COG0789	Transcriptional regulator
D5E69_06805	COG1278	Cold shock
D5E69_06815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D5E69_06815	COG2124	cytochrome p450
D5E69_06820	COG1309	transcriptional regulator
D5E69_06825	COG3290	protein histidine kinase activity
D5E69_06830	COG3279	Response regulator of the LytR AlgR family
D5E69_06835	COG4555	ABC transporter
D5E69_06840	COG1668	transmembrane transport
D5E69_06850	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_06865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D5E69_06870	COG1115	amino acid carrier protein
D5E69_06875	COG2508	Transcriptional regulator
D5E69_06875	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D5E69_06880	COG2508	Transcriptional regulator
D5E69_06880	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D5E69_06885	COG0686	Belongs to the AlaDH PNT family
D5E69_06900	COG1725	Transcriptional regulator
D5E69_06905	COG0398	Pfam SNARE associated Golgi protein
D5E69_06930	COG0640	Transcriptional regulator
D5E69_06945	COG2205	protein histidine kinase activity
D5E69_06960	COG1131	(ABC) transporter
D5E69_06965	COG1114	Component of the transport system for branched-chain amino acids
D5E69_06975	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_06980	COG0604	alcohol dehydrogenase
D5E69_07000	COG2207	Transcriptional regulator
D5E69_07000	COG3708	Transcriptional regulator
D5E69_07035	COG0778	Nitroreductase
D5E69_07050	COG0247	lactate metabolic process
D5E69_07055	COG0277	FAD linked oxidase domain protein
D5E69_07065	COG2971	BadF BadG BcrA BcrD
D5E69_07075	COG1447	Phosphotransferase system cellobiose-specific component IIA
D5E69_07080	COG1737	Transcriptional regulator
D5E69_07100	COG1486	melibiose metabolic process
D5E69_07105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D5E69_07110	COG1649	PFAM Uncharacterised BCR, COG1649
D5E69_07120	COG0493	'glutamate synthase
D5E69_07125	COG1263	PTS System
D5E69_07125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_07135	COG1657	PFAM Prenyltransferase squalene oxidase
D5E69_07140	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D5E69_07160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5E69_07165	COG2268	Band 7 protein
D5E69_07170	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D5E69_07185	COG1073	alpha beta
D5E69_07190	COG0277	FAD linked oxidase domain protein
D5E69_07195	COG0385	Bile acid
D5E69_07205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_07210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_07215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_07220	COG1120	ATPase activity
D5E69_07230	COG0861	Integral membrane protein TerC family
D5E69_07250	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D5E69_07255	COG2270	Major facilitator Superfamily
D5E69_07270	COG0789	Transcriptional regulator
D5E69_07275	COG1725	Transcriptional regulator
D5E69_07280	COG1131	(ABC) transporter
D5E69_07315	COG2186	Transcriptional regulator
D5E69_07320	COG0277	FAD linked oxidase domain protein
D5E69_07325	COG0247	lactate metabolic process
D5E69_07330	COG0579	oxidoreductase
D5E69_07335	COG0542	response to heat
D5E69_07340	COG0561	phosphatase activity
D5E69_07345	COG1132	(ABC) transporter
D5E69_07350	COG3695	enzyme binding
D5E69_07365	COG1090	epimerase
D5E69_07375	COG0300	oxidoreductase activity
D5E69_07405	COG1194	a g-specific adenine glycosylase
D5E69_07415	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_07430	COG3557	Belongs to the UPF0374 family
D5E69_07435	COG1132	(ABC) transporter
D5E69_07440	COG0444	Belongs to the ABC transporter superfamily
D5E69_07445	COG4608	Belongs to the ABC transporter superfamily
D5E69_07450	COG0747	negative chemotaxis
D5E69_07465	COG4129	membrane
D5E69_07470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5E69_07480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5E69_07490	COG2096	Adenosyltransferase
D5E69_07495	COG0735	belongs to the Fur family
D5E69_07625	COG2972	Histidine kinase
D5E69_07640	COG0673	inositol 2-dehydrogenase activity
D5E69_07645	COG0673	inositol 2-dehydrogenase activity
D5E69_07650	COG1082	Xylose isomerase domain protein TIM barrel
D5E69_07655	COG3382	B3 4 domain protein
D5E69_07670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D5E69_07675	COG0778	Nitroreductase
D5E69_07680	COG2766	serine protein kinase
D5E69_07700	COG2267	carboxylic ester hydrolase activity
D5E69_07705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5E69_07710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D5E69_07715	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5E69_07730	COG0039	L-malate dehydrogenase activity
D5E69_07745	COG2252	PERMEase
D5E69_07750	COG1522	sequence-specific DNA binding
D5E69_07760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5E69_07765	COG0789	Transcriptional regulator
D5E69_07765	COG4978	Transcriptional regulator
D5E69_07780	COG4988	ABC transporter
D5E69_07785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D5E69_07790	COG0778	Nitroreductase
D5E69_07795	COG1609	Transcriptional regulator
D5E69_07810	COG2205	protein histidine kinase activity
D5E69_07815	COG5002	protein histidine kinase activity
D5E69_07820	COG0546	phosphoglycolate phosphatase activity
D5E69_07825	COG3973	AAA domain
D5E69_07830	COG0656	L-ascorbic acid biosynthetic process
D5E69_07835	COG0564	pseudouridine synthase activity
D5E69_07850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D5E69_07855	COG3153	acetyltransferase
D5E69_07855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5E69_07860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5E69_07865	COG4585	Histidine kinase
D5E69_07865	COG2203	Gaf domain
D5E69_07870	COG2197	response regulator
D5E69_07875	COG0431	NADPH-dependent FMN reductase
D5E69_07895	COG2719	SpoVR family
D5E69_07910	COG4989	oxidoreductase activity
D5E69_07920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5E69_07925	COG0011	TIGRFAM Protein of
D5E69_07930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5E69_07940	COG0084	hydrolase, TatD family'
D5E69_07950	COG1533	DNA photolyase activity
D5E69_07960	COG1301	dicarboxylic acid transport
D5E69_07970	COG0415	Belongs to the DNA photolyase family
D5E69_07975	COG0589	response to stress
D5E69_07980	COG1132	(ABC) transporter
D5E69_07990	COG0702	epimerase
D5E69_07995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5E69_08000	COG0765	amino acid transport
D5E69_08005	COG1126	abc transporter atp-binding protein
D5E69_08025	COG3842	ATPase activity
D5E69_08030	COG2508	Transcriptional regulator
D5E69_08035	COG1937	Protein conserved in bacteria
D5E69_08060	COG0189	ligase activity
D5E69_08065	COG0189	ligase activity
D5E69_08070	COG0189	ligase activity
D5E69_08075	COG4399	Belongs to the UPF0754 family
D5E69_08085	COG0561	phosphatase activity
D5E69_08090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5E69_08095	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_08100	COG1024	Enoyl-CoA hydratase
D5E69_08110	COG0420	3'-5' exonuclease activity
D5E69_08115	COG4717	serine-type aminopeptidase activity
D5E69_08120	COG3481	metal-dependent phosphohydrolase, HD sub domain
D5E69_08130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5E69_08165	COG1846	Transcriptional regulator
D5E69_08170	COG4980	gas vesicle protein
D5E69_08185	COG0537	adenosine 5'-monophosphoramidase activity
D5E69_08195	COG1131	(ABC) transporter
D5E69_08200	COG4473	ABC transporter
D5E69_08220	COG3069	C4-dicarboxylate transmembrane transporter activity
D5E69_08225	COG2329	Antibiotic biosynthesis monooxygenase
D5E69_08230	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D5E69_08245	COG1309	transcriptional regulator
D5E69_08250	COG1511	domain protein
D5E69_08265	COG1234	tRNA 3'-trailer cleavage
D5E69_08270	COG0095	Lipoate-protein ligase
D5E69_08275	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_08280	COG1024	Enoyl-CoA hydratase
D5E69_08290	COG2112	serine threonine protein kinase
D5E69_08295	COG2391	methyltransferase activity
D5E69_08300	COG1396	sequence-specific DNA binding
D5E69_08305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D5E69_08315	COG0501	Belongs to the peptidase M48B family
D5E69_08320	COG2323	membrane
D5E69_08330	COG4903	ComK protein
D5E69_08340	COG1506	peptidase
D5E69_08340	COG4946	Tricorn protease homolog
D5E69_08340	COG0823	Involved in the tonB-independent uptake of proteins
D5E69_08345	COG0398	Pfam SNARE associated Golgi protein
D5E69_08355	COG2356	endonuclease I
D5E69_08360	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D5E69_08365	COG1074	ATP-dependent DNA helicase activity
D5E69_08400	COG2311	Membrane
D5E69_08405	COG0179	Fumarylacetoacetate (FAA) hydrolase
D5E69_08420	COG0367	asparagine synthase
D5E69_08435	COG1562	ergosterol biosynthetic process
D5E69_08440	COG0004	ammonium transporteR
D5E69_08445	COG0347	Belongs to the P(II) protein family
D5E69_08450	COG0534	Mate efflux family protein
D5E69_08460	COG2182	Extracellular solute-binding protein
D5E69_08465	COG1175	transmembrane transport
D5E69_08470	COG3833	ABC-type maltose transport systems, permease component
D5E69_08475	COG1874	Beta-galactosidase
D5E69_08475	COG0366	Alpha amylase catalytic
D5E69_08480	COG1609	Transcriptional regulator
D5E69_08485	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_08495	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5E69_08500	COG1666	GTP binding
D5E69_08510	COG1307	EDD domain protein, DegV family
D5E69_08515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_08525	COG0561	phosphatase activity
D5E69_08530	COG1073	alpha beta
D5E69_08535	COG2151	metal-sulfur cluster biosynthetic enzyme
D5E69_08540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5E69_08545	COG1968	undecaprenyl-diphosphatase activity
D5E69_08575	COG2267	carboxylic ester hydrolase activity
D5E69_08585	COG1744	ABC transporter substrate-binding protein PnrA-like
D5E69_08595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_08600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5E69_08615	COG0180	Tryptophanyl-tRNA synthetase
D5E69_08625	COG4166	transmembrane transport
D5E69_08630	COG0601	transmembrane transport
D5E69_08635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5E69_08640	COG0444	Belongs to the ABC transporter superfamily
D5E69_08645	COG4608	Belongs to the ABC transporter superfamily
D5E69_08655	COG0456	acetyltransferase
D5E69_08660	COG1393	Belongs to the ArsC family
D5E69_08665	COG4862	establishment of competence for transformation
D5E69_08670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5E69_08680	COG1164	Oligoendopeptidase f
D5E69_08690	COG2346	COG2346, Truncated hemoglobins
D5E69_08695	COG0741	lytic transglycosylase activity
D5E69_08700	COG4116	CYTH
D5E69_08710	COG2357	RelA SpoT domain protein
D5E69_08715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5E69_08720	COG0564	pseudouridine synthase activity
D5E69_08725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5E69_08730	COG2239	Acts as a magnesium transporter
D5E69_08735	COG0475	glutathione-regulated potassium exporter activity
D5E69_08735	COG0569	domain protein
D5E69_08745	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D5E69_08775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_08800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_08805	COG2323	membrane
D5E69_08810	COG2153	protein acetylation
D5E69_08815	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D5E69_08820	COG2382	esterase
D5E69_08825	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D5E69_08860	COG0183	Belongs to the thiolase family
D5E69_08870	COG1737	Transcriptional regulator
D5E69_08875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D5E69_08880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5E69_08885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5E69_08890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5E69_08900	COG1764	response to oxidative stress
D5E69_08905	COG1295	ribonuclease BN
D5E69_08910	COG1363	Peptidase, m42
D5E69_08915	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D5E69_08920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5E69_08925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D5E69_08930	COG2200	EAL domain
D5E69_08945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5E69_08955	COG0861	Integral membrane protein TerC family
D5E69_08960	COG1191	sigma factor activity
D5E69_08975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5E69_08990	COG3594	Acyltransferase
D5E69_08995	COG5002	protein histidine kinase activity
D5E69_09000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5E69_09005	COG0640	Transcriptional regulator
D5E69_09010	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D5E69_09015	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D5E69_09030	COG1850	ribulose-bisphosphate carboxylase activity
D5E69_09035	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D5E69_09040	COG0235	Class ii aldolase
D5E69_09055	COG1846	Transcriptional regulator
D5E69_09070	COG3949	Membrane
D5E69_09075	COG4873	Protein conserved in bacteria
D5E69_09085	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_09090	COG0714	Associated with various cellular activities
D5E69_09115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5E69_09120	COG0456	acetyltransferase
D5E69_09125	COG0436	Aminotransferase
D5E69_09130	COG0598	Magnesium transport protein CorA
D5E69_09140	COG0720	synthase
D5E69_09155	COG0835	chemotaxis
D5E69_09155	COG0784	Response regulator, receiver
D5E69_09170	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_09175	COG2200	EAL domain
D5E69_09195	COG4703	Protein of unknown function (DUF1797)
D5E69_09200	COG0517	IMP dehydrogenase activity
D5E69_09205	COG0583	DNA-binding transcription factor activity
D5E69_09215	COG1473	amidohydrolase
D5E69_09230	COG1131	(ABC) transporter
D5E69_09265	COG2304	oxidoreductase activity
D5E69_09270	COG0668	transmembrane transport
D5E69_09275	COG1132	(ABC) transporter
D5E69_09280	COG1132	(ABC) transporter
D5E69_09285	COG1271	oxidase subunit
D5E69_09290	COG1294	oxidase, subunit
D5E69_09300	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D5E69_09310	COG0561	phosphatase activity
D5E69_09330	COG0022	dehydrogenase e1 component
D5E69_09335	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5E69_09345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_09355	COG0726	polysaccharide deacetylase
D5E69_09365	COG1982	Orn Lys Arg decarboxylase major
D5E69_09375	COG4476	Belongs to the UPF0223 family
D5E69_09380	COG4493	Belongs to the UPF0637 family
D5E69_09390	COG0483	inositol monophosphate 1-phosphatase activity
D5E69_09415	COG4896	Protein conserved in bacteria
D5E69_09430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D5E69_09435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D5E69_09440	COG2066	Belongs to the glutaminase family
D5E69_09450	COG0772	Belongs to the SEDS family
D5E69_09455	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D5E69_09460	COG1612	heme a metabolic process
D5E69_09490	COG3336	cytochrome c oxidase
D5E69_09515	COG2340	Cysteine-rich secretory protein family
D5E69_09520	COG2050	protein possibly involved in aromatic compounds catabolism
D5E69_09540	COG3679	Belongs to the UPF0342 family
D5E69_09560	COG0742	ribosomal rna small subunit methyltransferase
D5E69_09565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D5E69_09570	COG3314	Sporulation integral membrane protein YlbJ
D5E69_09575	COG1752	Esterase of the alpha-beta hydrolase superfamily
D5E69_09580	COG3480	Lon protease (S16) C-terminal proteolytic domain
D5E69_09590	COG1399	metal-binding, possibly nucleic acid-binding protein
D5E69_09600	COG1024	Enoyl-CoA hydratase
D5E69_09610	COG0454	-acetyltransferase
D5E69_09620	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D5E69_09625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D5E69_09630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D5E69_09645	COG2001	Belongs to the MraZ family
D5E69_09665	COG0768	penicillin binding
D5E69_09680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5E69_09695	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D5E69_09700	COG3879	Bacterial protein of unknown function (DUF881)
D5E69_09705	COG3879	Bacterial protein of unknown function (DUF881)
D5E69_09710	COG3856	small basic protein
D5E69_09715	COG0849	cell division
D5E69_09720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D5E69_09730	COG1191	sigma factor activity
D5E69_09735	COG1191	sigma factor activity
D5E69_09740	COG1873	PFAM PRC-barrel domain
D5E69_09750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D5E69_09755	COG1799	cell septum assembly
D5E69_09760	COG0762	integral membrane protein
D5E69_09765	COG2302	S4 RNA-binding domain
D5E69_09770	COG3599	regulation of cell shape
D5E69_09785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5E69_09790	COG0564	pseudouridine synthase activity
D5E69_09795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D5E69_09800	COG2233	PERMEase
D5E69_09810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D5E69_09820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D5E69_09830	COG0167	dihydroorotate dehydrogenase activity
D5E69_09850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D5E69_09855	COG1561	YicC-like family, N-terminal region
D5E69_09860	COG2052	Domain of unknown function (DUF370)
D5E69_09865	COG0194	GDP metabolic process
D5E69_09875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5E69_09880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D5E69_09885	COG0242	peptide deformylase activity
D5E69_09890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D5E69_09895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5E69_09895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D5E69_09900	COG0631	protein serine/threonine phosphatase activity
D5E69_09905	COG2815	serine threonine protein kinase
D5E69_09905	COG0515	serine threonine protein kinase
D5E69_09910	COG1162	GTPase activity
D5E69_09915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5E69_09920	COG1564	THIamine pyrophosphokinase
D5E69_09930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D5E69_09935	COG1302	Protein conserved in bacteria
D5E69_09940	COG1461	Dihydroxyacetone kinase
D5E69_09945	COG1760	l-serine dehydratase
D5E69_09955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5E69_09960	COG1349	DNA-binding transcription factor activity
D5E69_09965	COG0416	fatty acid biosynthetic process
D5E69_09970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5E69_09975	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_09980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5E69_09990	COG1196	nuclear chromosome segregation
D5E69_09995	COG0552	protein localization to endoplasmic reticulum
D5E69_10000	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D5E69_10005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5E69_10010	COG0228	four-way junction DNA binding
D5E69_10015	COG1837	Belongs to the UPF0109 family
D5E69_10025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D5E69_10030	COG0336	Belongs to the RNA methyltransferase TrmD family
D5E69_10035	COG0335	large ribosomal subunit rRNA binding
D5E69_10045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D5E69_10050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5E69_10060	COG2257	FlhB HrpN YscU SpaS Family
D5E69_10070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D5E69_10075	COG0758	DNA mediated transformation
D5E69_10080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5E69_10085	COG4974	Belongs to the 'phage' integrase family
D5E69_10090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D5E69_10100	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D5E69_10105	COG1815	bacterial-type flagellum-dependent cell motility
D5E69_10110	COG1558	bacterial-type flagellum-dependent cell motility
D5E69_10115	COG1677	Flagellar hook-basal body complex protein FliE
D5E69_10120	COG1766	The M ring may be actively involved in energy transduction
D5E69_10125	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5E69_10130	COG1317	bacterial-type flagellum organization
D5E69_10135	COG1157	protein secretion by the type III secretion system
D5E69_10140	COG2882	bacterial-type flagellum organization
D5E69_10150	COG3144	bacterial-type flagellum assembly
D5E69_10155	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D5E69_10160	COG1749	Flagellar hook protein flgE
D5E69_10165	COG1582	Flagellar protein (FlbD)
D5E69_10170	COG1580	Controls the rotational direction of flagella during chemotaxis
D5E69_10175	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5E69_10180	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5E69_10180	COG1776	CheC inhibitor of MCP methylation
D5E69_10185	COG2201	protein-glutamate methylesterase activity
D5E69_10190	COG3190	flagellar
D5E69_10195	COG1338	Plays a role in the flagellum-specific transport system
D5E69_10200	COG1987	bacterial-type flagellum assembly
D5E69_10205	COG1684	flagellar biosynthetic protein fliR
D5E69_10210	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5E69_10215	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5E69_10220	COG1419	protein localization to endoplasmic reticulum
D5E69_10225	COG0455	bacterial-type flagellum organization
D5E69_10235	COG0643	Histidine kinase
D5E69_10235	COG2198	Histidine kinase
D5E69_10240	COG0835	chemotaxis
D5E69_10245	COG1776	CheC inhibitor of MCP methylation
D5E69_10250	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D5E69_10255	COG1191	sigma factor activity
D5E69_10270	COG0052	Belongs to the universal ribosomal protein uS2 family
D5E69_10280	COG0528	UMP kinase activity
D5E69_10285	COG0233	cytoplasmic translational termination
D5E69_10290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D5E69_10295	COG4589	Belongs to the CDS family
D5E69_10305	COG0750	zinc metalloprotease
D5E69_10310	COG0442	prolyl-tRNA aminoacylation
D5E69_10315	COG2176	DNA-directed DNA polymerase activity
D5E69_10320	COG0779	Required for maturation of 30S ribosomal subunits
D5E69_10325	COG0195	Participates in both transcription termination and antitermination
D5E69_10330	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D5E69_10335	COG1358	cellular component organization or biogenesis
D5E69_10340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D5E69_10345	COG1550	Protein conserved in bacteria
D5E69_10350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D5E69_10360	COG0196	riboflavin kinase activity
D5E69_10370	COG1185	polyribonucleotide nucleotidyltransferase activity
D5E69_10375	COG0726	polysaccharide deacetylase
D5E69_10380	COG0612	Peptidase, M16
D5E69_10385	COG1873	PFAM PRC-barrel domain
D5E69_10390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5E69_10395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5E69_10400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D5E69_10405	COG0527	aspartate kinase activity
D5E69_10415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D5E69_10420	COG0740	serine-type endopeptidase activity
D5E69_10430	COG4980	gas vesicle protein
D5E69_10430	COG1674	ftsk spoiiie
D5E69_10435	COG2188	Transcriptional regulator
D5E69_10460	COG0612	Peptidase, M16
D5E69_10465	COG0612	Peptidase, M16
D5E69_10470	COG0300	oxidoreductase activity
D5E69_10485	COG1426	Protein conserved in bacteria
D5E69_10490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5E69_10500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D5E69_10510	COG1692	metallophosphoesterase
D5E69_10515	COG2359	stage V sporulation protein S
D5E69_10525	COG0674	pyruvate-flavodoxin oxidoreductase activity
D5E69_10525	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D5E69_10530	COG1013	pyruvate-flavodoxin oxidoreductase activity
D5E69_10555	COG1216	Glycosyl transferase, family 2
D5E69_10560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5E69_10585	COG0438	transferase activity, transferring glycosyl groups
D5E69_10595	COG1086	Polysaccharide biosynthesis protein
D5E69_10610	COG0438	transferase activity, transferring glycosyl groups
D5E69_10610	COG1216	Glycosyl transferase, family 2
D5E69_10625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5E69_10630	COG4550	Control of competence regulator ComK, YlbF/YmcA
D5E69_10640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5E69_10640	COG0551	DNA topoisomerase type I activity
D5E69_10650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5E69_10655	COG2720	vancomycin resistance protein
D5E69_10665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D5E69_10700	COG1923	regulation of RNA biosynthetic process
D5E69_10705	COG0464	growth
D5E69_10710	COG2860	membrane
D5E69_10715	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D5E69_10720	COG0789	Transcriptional regulator
D5E69_10725	COG0174	glutamine synthetase
D5E69_10730	COG0659	secondary active sulfate transmembrane transporter activity
D5E69_10740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5E69_10745	COG1388	LysM domain
D5E69_10750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D5E69_10755	COG4224	UPF0291 protein
D5E69_10775	COG3763	UPF0154 protein
D5E69_10780	COG4851	CamS sex pheromone cAM373 precursor
D5E69_10785	COG1132	(ABC) transporter
D5E69_10790	COG1132	(ABC) transporter
D5E69_10800	COG0785	Cytochrome C biogenesis protein
D5E69_10805	COG2201	protein-glutamate methylesterase activity
D5E69_10810	COG4846	Membrane protein involved in cytochrome C biogenesis
D5E69_10820	COG3852	Histidine kinase
D5E69_10840	COG0419	ATPase involved in DNA repair
D5E69_10850	COG1999	signal sequence binding
D5E69_10860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5E69_10870	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D5E69_10885	COG1063	alcohol dehydrogenase
D5E69_10895	COG0626	cystathionine gamma-synthase activity
D5E69_10900	COG0646	methionine synthase
D5E69_10900	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D5E69_10905	COG0646	methionine synthase
D5E69_10905	COG1410	methionine synthase
D5E69_10910	COG1366	Belongs to the anti-sigma-factor antagonist family
D5E69_10920	COG1366	Belongs to the anti-sigma-factor antagonist family
D5E69_10925	COG0346	lactoylglutathione lyase activity
D5E69_10930	COG0400	carboxylic ester hydrolase activity
D5E69_10950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D5E69_10955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D5E69_10965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_10970	COG1968	undecaprenyl-diphosphatase activity
D5E69_10990	COG1183	phosphatidylcholine synthase activity
D5E69_11020	COG5566	PFAM Mor transcription activator
D5E69_11030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D5E69_11035	COG1846	Transcriptional regulator
D5E69_11040	COG0778	Nitroreductase
D5E69_11060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5E69_11075	COG1216	Glycosyl transferase, family 2
D5E69_11080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5E69_11080	COG0438	transferase activity, transferring glycosyl groups
D5E69_11085	COG0730	response to heat
D5E69_11090	COG1309	transcriptional regulator
D5E69_11095	COG2814	Major facilitator Superfamily
D5E69_11115	COG1231	oxidoreductase activity
D5E69_11125	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_11145	COG0204	Acyl-transferase
D5E69_11170	COG1113	amino acid transport
D5E69_11175	COG2814	Major facilitator Superfamily
D5E69_11180	COG1942	4-Oxalocrotonate Tautomerase
D5E69_11200	COG1597	lipid kinase activity
D5E69_11210	COG0322	excinuclease ABC activity
D5E69_11220	COG3275	phosphorelay sensor kinase activity
D5E69_11225	COG4753	response regulator
D5E69_11225	COG2207	Transcriptional regulator
D5E69_11230	COG4977	sequence-specific DNA binding
D5E69_11240	COG4209	transmembrane transport
D5E69_11245	COG0395	ABC-type sugar transport system, permease component
D5E69_11255	COG1621	beta-fructofuranosidase activity
D5E69_11260	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D5E69_11265	COG1414	Transcriptional regulator
D5E69_11270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5E69_11275	COG0352	thiamine-phosphate diphosphorylase activity
D5E69_11285	COG2610	gluconate transmembrane transporter activity
D5E69_11290	COG0109	protoheme IX farnesyltransferase activity
D5E69_11295	COG1309	transcriptional regulator
D5E69_11300	COG0586	Pfam SNARE associated Golgi protein
D5E69_11330	COG0583	DNA-binding transcription factor activity
D5E69_11335	COG0372	Belongs to the citrate synthase family
D5E69_11340	COG0456	acetyltransferase
D5E69_11345	COG3852	Histidine kinase
D5E69_11380	COG1253	flavin adenine dinucleotide binding
D5E69_11385	COG0789	Transcriptional regulator
D5E69_11390	COG2362	D-Aminopeptidase
D5E69_11395	COG0601	transmembrane transport
D5E69_11400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5E69_11405	COG0444	Belongs to the ABC transporter superfamily
D5E69_11410	COG4166	transmembrane transport
D5E69_11420	COG4948	Mandelate Racemase Muconate Lactonizing
D5E69_11425	COG0791	NLP P60 protein
D5E69_11440	COG0500	methyltransferase
D5E69_11460	COG1131	(ABC) transporter
D5E69_11465	COG4473	ABC transporter
D5E69_11470	COG0456	acetyltransferase
D5E69_11480	COG5632	N-Acetylmuramoyl-L-alanine amidase
D5E69_11490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D5E69_11510	COG4326	sporulation control protein
D5E69_11545	COG2309	aminopeptidase activity
D5E69_11550	COG3152	Membrane
D5E69_11555	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D5E69_11560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D5E69_11565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D5E69_11570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D5E69_11575	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_11585	COG0006	proline dipeptidase activity
D5E69_11600	COG1380	Effector of murein hydrolase LrgA
D5E69_11605	COG1346	cytolysis
D5E69_11610	COG0024	Methionine aminopeptidase
D5E69_11615	COG1388	LysM domain
D5E69_11615	COG3584	3D domain protein
D5E69_11620	COG3583	domain protein
D5E69_11620	COG3584	3D domain protein
D5E69_11625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D5E69_11660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D5E69_11665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_11685	COG0824	Thioesterase
D5E69_11695	COG4841	protein insertion into membrane
D5E69_11700	COG2843	Capsule synthesis protein
D5E69_11705	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D5E69_11710	COG2233	PERMEase
D5E69_11715	COG1832	CoA-binding protein
D5E69_11720	COG0187	DNA topoisomerase II activity
D5E69_11730	COG1115	amino acid carrier protein
D5E69_11735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5E69_11740	COG0697	spore germination
D5E69_11755	COG1253	flavin adenine dinucleotide binding
D5E69_11785	COG2814	Major facilitator Superfamily
D5E69_11810	COG0667	Aldo Keto reductase
D5E69_11815	COG1309	transcriptional regulator
D5E69_11820	COG0477	Major facilitator Superfamily
D5E69_11850	COG1366	Belongs to the anti-sigma-factor antagonist family
D5E69_11865	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_11870	COG0778	Nitroreductase
D5E69_11885	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D5E69_11895	COG0726	polysaccharide deacetylase
D5E69_11900	COG0693	protein deglycase activity
D5E69_11920	COG0561	phosphatase activity
D5E69_11935	COG2190	(PTS) system
D5E69_11935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_11935	COG1263	PTS System
D5E69_11940	COG1486	melibiose metabolic process
D5E69_11945	COG1737	Transcriptional regulator
D5E69_11950	COG2070	2-Nitropropane dioxygenase
D5E69_11955	COG2814	Major facilitator Superfamily
D5E69_11975	COG1174	glycine betaine transport
D5E69_11980	COG0517	IMP dehydrogenase activity
D5E69_11980	COG1125	glycine betaine transport
D5E69_12000	COG2233	PERMEase
D5E69_12005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5E69_12010	COG1648	precorrin-2 dehydrogenase activity
D5E69_12015	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D5E69_12030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5E69_12035	COG0529	Catalyzes the synthesis of activated sulfate
D5E69_12045	COG0306	phosphate transporter
D5E69_12060	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_12065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D5E69_12070	COG0351	phosphomethylpyrimidine kinase
D5E69_12075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D5E69_12080	COG2022	thiamine diphosphate biosynthetic process
D5E69_12090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5E69_12095	COG0352	thiamine-phosphate diphosphorylase activity
D5E69_12100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D5E69_12105	COG2197	response regulator
D5E69_12110	COG4585	Histidine kinase
D5E69_12130	COG4589	Belongs to the CDS family
D5E69_12145	COG0708	Exodeoxyribonuclease III
D5E69_12155	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D5E69_12160	COG2340	Cysteine-rich secretory protein family
D5E69_12165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D5E69_12170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5E69_12185	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D5E69_12190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5E69_12200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5E69_12210	COG0693	protein deglycase activity
D5E69_12215	COG2084	Dehydrogenase
D5E69_12225	COG0745	RESPONSE REGULATOR receiver
D5E69_12230	COG5002	protein histidine kinase activity
D5E69_12235	COG4086	secreted protein
D5E69_12265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D5E69_12270	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D5E69_12280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5E69_12305	COG1316	TRANSCRIPTIONal
D5E69_12315	COG1120	ATPase activity
D5E69_12320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_12325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_12335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5E69_12360	COG2996	Protein conserved in bacteria
D5E69_12365	COG2252	PERMEase
D5E69_12380	COG0488	(ABC) transporter
D5E69_12385	COG0514	ATP-dependent DNA helicase (RecQ)
D5E69_12435	COG1686	Belongs to the peptidase S11 family
D5E69_12440	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
D5E69_12445	COG3853	Toxic anion resistance protein (TelA)
D5E69_12450	COG4548	von Willebrand factor, type A
D5E69_12455	COG0714	Associated with various cellular activities
D5E69_12470	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D5E69_12470	COG2105	PFAM AIG2 family protein
D5E69_12475	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_12485	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5E69_12500	COG5002	protein histidine kinase activity
D5E69_12510	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D5E69_12515	COG0432	Pfam Uncharacterised protein family UPF0047
D5E69_12520	COG3011	Protein conserved in bacteria
D5E69_12525	COG0406	alpha-ribazole phosphatase activity
D5E69_12550	COG1309	transcriptional regulator
D5E69_12555	COG2076	Multidrug Resistance protein
D5E69_12560	COG2076	Multidrug Resistance protein
D5E69_12575	COG0697	spore germination
D5E69_12580	COG0628	permease
D5E69_12585	COG2153	protein acetylation
D5E69_12590	COG3340	Belongs to the peptidase S51 family
D5E69_12595	COG2814	Major facilitator Superfamily
D5E69_12600	COG1278	Cold shock
D5E69_12660	COG4106	trans-aconitate 2-methyltransferase activity
D5E69_12665	COG0159	tryptophan synthase activity
D5E69_12680	COG0134	indole-3-glycerol-phosphate synthase activity
D5E69_12690	COG0512	Glutamine amidotransferase of anthranilate synthase
D5E69_12700	COG1233	COG1233 Phytoene dehydrogenase and related
D5E69_12705	COG4145	pantothenate transmembrane transporter activity
D5E69_12715	COG0671	phosphoesterase, PA-phosphatase related
D5E69_12720	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D5E69_12745	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D5E69_12750	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5E69_12750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5E69_12755	COG0307	riboflavin synthase, alpha
D5E69_12760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5E69_12760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5E69_12775	COG4667	esterase of the alpha-beta hydrolase superfamily
D5E69_12780	COG0494	nUDIX hydrolase
D5E69_12800	COG0586	Pfam SNARE associated Golgi protein
D5E69_12830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5E69_12840	COG1215	transferase activity, transferring glycosyl groups
D5E69_12860	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_12865	COG2340	Cysteine-rich secretory protein family
D5E69_12880	COG0477	Major facilitator Superfamily
D5E69_12885	COG1846	Transcriptional regulator
D5E69_12890	COG0523	cobalamin synthesis protein
D5E69_12900	COG3409	Peptidoglycan-binding domain 1 protein
D5E69_12900	COG0793	Belongs to the peptidase S41A family
D5E69_12910	COG1876	peptidase activity
D5E69_12925	COG4326	sporulation control protein
D5E69_12950	COG4479	Belongs to the UPF0346 family
D5E69_12960	COG1509	lysine 2,3-aminomutase activity
D5E69_12975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D5E69_12980	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D5E69_12985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5E69_12990	COG0840	transmembrane signaling receptor activity
D5E69_13000	COG2190	(PTS) system
D5E69_13005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5E69_13010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5E69_13025	COG4698	Protein conserved in bacteria
D5E69_13030	COG2755	lipolytic protein G-D-S-L family
D5E69_13050	COG1272	protein, Hemolysin III
D5E69_13055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D5E69_13075	COG2521	methyltransferase
D5E69_13075	COG2136	Putative SAM-dependent methyltransferase
D5E69_13085	COG1413	lyase activity
D5E69_13090	COG0488	(ABC) transporter
D5E69_13095	COG1418	mRNA catabolic process
D5E69_13115	COG2226	methyltransferase
D5E69_13125	COG1321	iron dependent repressor
D5E69_13130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5E69_13135	COG1321	iron dependent repressor
D5E69_13135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5E69_13140	COG1121	(ABC) transporter
D5E69_13145	COG0803	Belongs to the bacterial solute-binding protein 9 family
D5E69_13150	COG1278	Cold shock
D5E69_13160	COG0328	RNA-DNA hybrid ribonuclease activity
D5E69_13165	COG0328	RNA-DNA hybrid ribonuclease activity
D5E69_13180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5E69_13195	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D5E69_13205	COG1755	Isoprenylcysteine carboxyl methyltransferase
D5E69_13210	COG3424	synthase
D5E69_13215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D5E69_13220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5E69_13225	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D5E69_13230	COG1199	ATP-dependent helicase activity
D5E69_13240	COG0116	Belongs to the methyltransferase superfamily
D5E69_13250	COG3599	regulation of cell shape
D5E69_13255	COG4474	Belongs to the UPF0398 family
D5E69_13265	COG3359	exonuclease
D5E69_13270	COG1205	dead DEAH box helicase
D5E69_13270	COG1111	helicase
D5E69_13275	COG0071	Belongs to the small heat shock protein (HSP20) family
D5E69_13310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5E69_13310	COG4499	WXG100 protein secretion system (Wss), protein YukC
D5E69_13320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D5E69_13325	COG3935	DnaD domain protein
D5E69_13350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5E69_13350	COG1199	ATP-dependent helicase activity
D5E69_13360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D5E69_13370	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D5E69_13370	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D5E69_13375	COG0617	tRNA 3'-terminal CCA addition
D5E69_13380	COG0438	transferase activity, transferring glycosyl groups
D5E69_13385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D5E69_13390	COG1803	Methylglyoxal synthase
D5E69_13395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D5E69_13400	COG1694	Mazg nucleotide pyrophosphohydrolase
D5E69_13410	COG2738	Putative neutral zinc metallopeptidase
D5E69_13420	COG4347	Protein of unknown function (DUF1405)
D5E69_13430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D5E69_13470	COG0287	Prephenate dehydrogenase
D5E69_13475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5E69_13480	COG4401	Chorismate mutase type I
D5E69_13485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D5E69_13490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D5E69_13495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5E69_13500	COG0105	UTP biosynthetic process
D5E69_13510	COG2226	methyltransferase
D5E69_13515	COG0142	geranyltranstransferase activity
D5E69_13525	COG0302	gtp cyclohydrolase
D5E69_13530	COG0776	regulation of translation
D5E69_13535	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D5E69_13555	COG1160	GTP binding
D5E69_13585	COG0539	negative regulation of cytoplasmic translation
D5E69_13590	COG0204	Acyl-transferase
D5E69_13595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D5E69_13615	COG3773	Cell wall hydrolase
D5E69_13615	COG3409	Peptidoglycan-binding domain 1 protein
D5E69_13620	COG2339	peptidase activity
D5E69_13625	COG0252	asparaginase activity
D5E69_13630	COG0492	ferredoxin-NADP+ reductase activity
D5E69_13635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5E69_13640	COG4862	establishment of competence for transformation
D5E69_13645	COG0789	Transcriptional regulator
D5E69_13650	COG1408	metallophosphoesterase
D5E69_13675	COG3546	catalase activity
D5E69_13685	COG1388	LysM domain
D5E69_13690	COG1266	CAAX protease self-immunity
D5E69_13695	COG0514	ATP-dependent DNA helicase (RecQ)
D5E69_13700	COG4955	Helix-turn-helix domain
D5E69_13705	COG1141	Ferredoxin
D5E69_13710	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D5E69_13715	COG0739	heme binding
D5E69_13725	COG1595	DNA-templated transcription, initiation
D5E69_13730	COG5002	protein histidine kinase activity
D5E69_13735	COG0745	RESPONSE REGULATOR receiver
D5E69_13740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5E69_13745	COG1333	cytochrome c biogenesis protein
D5E69_13750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_13755	COG1187	pseudouridine synthase activity
D5E69_13760	COG0700	Nucleoside recognition
D5E69_13770	COG1686	Belongs to the peptidase S11 family
D5E69_13775	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D5E69_13785	COG1547	Domain of unknown function (DUF309)
D5E69_13800	COG0697	spore germination
D5E69_13835	COG1686	Belongs to the peptidase S11 family
D5E69_13850	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D5E69_13855	COG4974	Belongs to the 'phage' integrase family
D5E69_13865	COG0735	belongs to the Fur family
D5E69_13870	COG1300	Membrane
D5E69_13885	COG0667	Aldo Keto reductase
D5E69_13895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D5E69_13900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D5E69_13910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5E69_13915	COG1073	alpha beta
D5E69_13930	COG4918	Iron-sulphur cluster biosynthesis
D5E69_13945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5E69_13970	COG0300	oxidoreductase activity
D5E69_13975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_13980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D5E69_13995	COG1234	tRNA 3'-trailer cleavage
D5E69_14000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D5E69_14005	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D5E69_14010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5E69_14020	COG2195	Cleaves the N-terminal amino acid of tripeptides
D5E69_14025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D5E69_14040	COG4129	membrane
D5E69_14045	COG1126	abc transporter atp-binding protein
D5E69_14050	COG0765	amino acid transport
D5E69_14055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5E69_14065	COG1703	isobutyryl-CoA mutase activity
D5E69_14070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_14070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_14075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_14080	COG1404	Belongs to the peptidase S8 family
D5E69_14080	COG4412	M6 family metalloprotease domain protein
D5E69_14085	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5E69_14090	COG0022	dehydrogenase e1 component
D5E69_14095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5E69_14105	COG3426	butyrate kinase activity
D5E69_14115	COG0280	phosphate acetyltransferase
D5E69_14120	COG3829	transcription factor binding
D5E69_14120	COG3290	protein histidine kinase activity
D5E69_14130	COG0584	glycerophosphoryl diester phosphodiesterase
D5E69_14140	COG5632	N-Acetylmuramoyl-L-alanine amidase
D5E69_14310	COG4974	Belongs to the 'phage' integrase family
D5E69_14385	COG0745	RESPONSE REGULATOR receiver
D5E69_14390	COG0750	zinc metalloprotease
D5E69_14405	COG0531	amino acid
D5E69_14410	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D5E69_14415	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5E69_14425	COG1722	exodeoxyribonuclease VII activity
D5E69_14430	COG1570	exodeoxyribonuclease VII activity
D5E69_14450	COG1302	Protein conserved in bacteria
D5E69_14455	COG0439	Biotin carboxylase
D5E69_14460	COG0511	ligase activity, forming carbon-carbon bonds
D5E69_14500	COG3854	ATPases associated with a variety of cellular activities
D5E69_14505	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D5E69_14510	COG0006	proline dipeptidase activity
D5E69_14515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D5E69_14530	COG1752	Esterase of the alpha-beta hydrolase superfamily
D5E69_14535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D5E69_14545	COG0583	DNA-binding transcription factor activity
D5E69_14550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5E69_14555	COG0095	Lipoate-protein ligase
D5E69_14560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5E69_14565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5E69_14570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5E69_14575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5E69_14580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5E69_14600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5E69_14620	COG4970	Tfp pilus assembly protein FimT
D5E69_14625	COG4537	Required for transformation and DNA binding
D5E69_14635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5E69_14680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5E69_14700	COG0411	ABC transporter
D5E69_14715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5E69_14720	COG2030	dehydratase
D5E69_14735	COG0840	transmembrane signaling receptor activity
D5E69_14740	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_14745	COG3942	CHAP domain
D5E69_14745	COG1388	LysM domain
D5E69_14755	COG1393	Belongs to the ArsC family
D5E69_14765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_14775	COG0011	TIGRFAM Protein of
D5E69_14800	COG1940	carbohydrate kinase activity
D5E69_14805	COG4483	Protein conserved in bacteria
D5E69_14810	COG0697	spore germination
D5E69_14820	COG0705	Rhomboid family
D5E69_14820	COG0457	Tetratricopeptide repeat
D5E69_14830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D5E69_14835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D5E69_14845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D5E69_14865	COG0840	transmembrane signaling receptor activity
D5E69_14870	COG0704	Plays a role in the regulation of phosphate uptake
D5E69_14875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5E69_14880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5E69_14885	COG0581	inorganic phosphate transmembrane transporter activity
D5E69_14890	COG0573	inorganic phosphate transmembrane transporter activity
D5E69_14895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D5E69_14905	COG0477	Major facilitator Superfamily
D5E69_14910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D5E69_14915	COG2839	Protein conserved in bacteria
D5E69_14920	COG1283	sodium-dependent phosphate transmembrane transporter activity
D5E69_14925	COG5521	maltodextrose utilization protein MalA
D5E69_14930	COG2814	Major facilitator Superfamily
D5E69_14940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D5E69_14945	COG4709	membrane
D5E69_14950	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
D5E69_14960	COG0735	belongs to the Fur family
D5E69_14970	COG1121	(ABC) transporter
D5E69_14980	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D5E69_14985	COG0513	Belongs to the DEAD box helicase family
D5E69_14995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D5E69_15005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D5E69_15010	COG2384	SAM-dependent methyltransferase
D5E69_15015	COG2010	Cytochrome c
D5E69_15020	COG1960	acyl-CoA dehydrogenase activity
D5E69_15030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5E69_15035	COG0358	DNA primase activity
D5E69_15040	COG1671	Belongs to the UPF0178 family
D5E69_15045	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D5E69_15050	COG0517	IMP dehydrogenase activity
D5E69_15055	COG0423	glycine-tRNA ligase activity
D5E69_15060	COG1381	Involved in DNA repair and RecF pathway recombination
D5E69_15075	COG0295	cytidine deaminase activity
D5E69_15080	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D5E69_15090	COG1480	7TM receptor with intracellular HD hydrolase
D5E69_15095	COG1702	phosphate starvation-inducible protein PhoH
D5E69_15120	COG4864	UPF0365 protein
D5E69_15130	COG1610	YqeY-like protein
D5E69_15135	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D5E69_15140	COG1283	sodium-dependent phosphate transmembrane transporter activity
D5E69_15150	COG0366	Alpha amylase catalytic
D5E69_15155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5E69_15160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D5E69_15165	COG2264	protein methyltransferase activity
D5E69_15170	COG0484	heat shock protein binding
D5E69_15180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5E69_15190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5E69_15195	COG0481	GTPase activity
D5E69_15205	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_15220	COG1466	dna polymerase III delta subunit
D5E69_15230	COG0658	competence protein
D5E69_15230	COG2333	competence protein COMEC
D5E69_15235	COG0658	competence protein
D5E69_15235	COG2333	competence protein COMEC
D5E69_15240	COG2131	deaminase
D5E69_15245	COG1555	photosystem II stabilization
D5E69_15245	COG1596	polysaccharide export
D5E69_15250	COG2226	methyltransferase
D5E69_15255	COG0799	negative regulation of ribosome biogenesis
D5E69_15260	COG1713	HD superfamily hydrolase involved in NAD metabolism
D5E69_15265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D5E69_15270	COG1534	Rna-binding protein
D5E69_15280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D5E69_15300	COG1183	phosphatidylcholine synthase activity
D5E69_15360	COG0626	cystathionine gamma-synthase activity
D5E69_15365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5E69_15370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D5E69_15375	COG2226	methyltransferase
D5E69_15390	COG0768	penicillin binding
D5E69_15395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5E69_15400	COG0572	uridine kinase
D5E69_15415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5E69_15420	COG3906	Belongs to the UPF0473 family
D5E69_15425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D5E69_15430	COG4472	Bacterial protein of unknown function (DUF965)
D5E69_15440	COG0628	permease
D5E69_15455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5E69_15465	COG0482	sulfurtransferase activity
D5E69_15470	COG1104	cysteine desulfurase activity
D5E69_15475	COG1959	2 iron, 2 sulfur cluster binding
D5E69_15480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D5E69_15490	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D5E69_15495	COG1131	(ABC) transporter
D5E69_15500	COG1131	(ABC) transporter
D5E69_15505	COG1725	Transcriptional regulator
D5E69_15515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D5E69_15520	COG1757	Na H antiporter
D5E69_15535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D5E69_15540	COG0124	histidyl-tRNA synthetase
D5E69_15555	COG3103	Sh3 type 3 domain protein
D5E69_15555	COG4991	sh3 domain protein
D5E69_15555	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_15560	COG1490	D-aminoacyl-tRNA deacylase activity
D5E69_15565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5E69_15570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5E69_15575	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D5E69_15575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D5E69_15580	COG5416	Lipopolysaccharide assembly protein A domain
D5E69_15585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5E69_15585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5E69_15595	COG2244	polysaccharide biosynthetic process
D5E69_15600	COG2323	membrane
D5E69_15610	COG1862	Preprotein translocase
D5E69_15620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D5E69_15635	COG0632	four-way junction helicase activity
D5E69_15655	COG1388	LysM domain
D5E69_15665	COG0157	Belongs to the NadC ModD family
D5E69_15670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D5E69_15675	COG1104	cysteine desulfurase activity
D5E69_15680	COG1827	regulation of RNA biosynthetic process
D5E69_15685	COG0077	Prephenate dehydratase
D5E69_15690	COG4492	Belongs to the UPF0735 family
D5E69_15695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5E69_15700	COG3290	protein histidine kinase activity
D5E69_15705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D5E69_15710	COG2868	ribosomal protein
D5E69_15715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D5E69_15720	COG1530	ribonuclease E activity
D5E69_15725	COG1994	Peptidase M50
D5E69_15730	COG0739	heme binding
D5E69_15735	COG2894	cell division
D5E69_15740	COG0850	regulation of cytokinetic process
D5E69_15750	COG1792	Involved in formation and maintenance of cell shape
D5E69_15755	COG1077	Cell shape determining protein MreB Mrl
D5E69_15760	COG2003	Belongs to the UPF0758 family
D5E69_15790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D5E69_15810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5E69_15830	COG3706	GGDEF domain
D5E69_15835	COG0285	dihydrofolate synthase activity
D5E69_15840	COG0525	valine-tRNA ligase activity
D5E69_15850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5E69_15855	COG1388	LysM domain
D5E69_15855	COG1388	LysM domain
D5E69_15865	COG0450	alkyl hydroperoxide reductase
D5E69_15875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5E69_15880	COG0113	porphobilinogen synthase activity
D5E69_15895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5E69_15910	COG1126	abc transporter atp-binding protein
D5E69_15920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5E69_15925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_15940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5E69_15945	COG1067	ATP-dependent peptidase activity
D5E69_15945	COG0470	DNA polymerase III
D5E69_15950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5E69_15955	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5E69_15980	COG0622	Phosphoesterase
D5E69_15995	COG5401	PFAM Sporulation and spore germination
D5E69_16000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D5E69_16005	COG1846	Transcriptional regulator
D5E69_16010	COG2197	response regulator
D5E69_16015	COG0824	Thioesterase
D5E69_16020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D5E69_16025	COG1053	succinate dehydrogenase
D5E69_16030	COG2009	succinate dehydrogenase
D5E69_16035	COG1719	4-vinyl reductase, 4VR
D5E69_16045	COG0322	excinuclease ABC activity
D5E69_16055	COG3118	belongs to the thioredoxin family
D5E69_16060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D5E69_16065	COG2086	electron transfer activity
D5E69_16070	COG1024	Enoyl-CoA hydratase
D5E69_16075	COG1309	transcriptional regulator
D5E69_16080	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_16085	COG3766	membrane
D5E69_16095	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D5E69_16095	COG1796	DNA polymerase
D5E69_16100	COG1286	toxin biosynthetic process
D5E69_16105	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D5E69_16110	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5E69_16115	COG0072	phenylalanine-tRNA ligase activity
D5E69_16115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5E69_16120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D5E69_16125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5E69_16135	COG1335	isochorismatase
D5E69_16140	COG1363	Peptidase, m42
D5E69_16165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D5E69_16175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D5E69_16180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5E69_16190	COG1484	DNA-dependent DNA replication
D5E69_16195	COG3611	Membrane attachment protein
D5E69_16210	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D5E69_16215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5E69_16220	COG0237	dephospho-CoA kinase activity
D5E69_16225	COG1971	Probably functions as a manganese efflux pump
D5E69_16230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D5E69_16235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5E69_16235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5E69_16245	COG0330	HflC and HflK could
D5E69_16250	COG5002	protein histidine kinase activity
D5E69_16255	COG0745	RESPONSE REGULATOR receiver
D5E69_16265	COG0039	L-malate dehydrogenase activity
D5E69_16270	COG0538	isocitrate dehydrogenase activity
D5E69_16275	COG0372	Belongs to the citrate synthase family
D5E69_16280	COG2707	UPF0756 membrane protein
D5E69_16285	COG0628	permease
D5E69_16290	COG3030	protein affecting phage T7 exclusion by the F plasmid
D5E69_16300	COG0205	6-phosphofructokinase activity
D5E69_16305	COG0825	malonyl-CoA metabolic process
D5E69_16310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D5E69_16315	COG1725	Transcriptional regulator
D5E69_16320	COG0281	malic enzyme
D5E69_16325	COG0587	DNA-directed DNA polymerase activity
D5E69_16340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D5E69_16350	COG4109	DRTGG domain
D5E69_16370	COG0589	response to stress
D5E69_16375	COG0165	Argininosuccinate lyase
D5E69_16380	COG0137	argininosuccinate synthase activity
D5E69_16400	COG0827	DNA restriction-modification system
D5E69_16405	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D5E69_16410	COG3874	Sporulation protein YtfJ
D5E69_16420	COG1714	RDD family
D5E69_16425	COG0616	signal peptide processing
D5E69_16430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5E69_16435	COG2962	Rard protein
D5E69_16440	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D5E69_16445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5E69_16455	COG0301	tRNA thio-modification
D5E69_16460	COG1104	cysteine desulfurase activity
D5E69_16465	COG1114	Component of the transport system for branched-chain amino acids
D5E69_16470	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D5E69_16475	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D5E69_16480	COG1309	transcriptional regulator
D5E69_16485	COG1956	GAF domain-containing protein
D5E69_16495	COG2199	diguanylate cyclase activity
D5E69_16495	COG2203	Gaf domain
D5E69_16500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D5E69_16515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5E69_16525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5E69_16530	COG0454	-acetyltransferase
D5E69_16535	COG0517	IMP dehydrogenase activity
D5E69_16540	COG0123	including yeast histone deacetylase and acetoin utilization protein
D5E69_16545	COG3973	AAA domain
D5E69_16565	COG1605	Chorismate mutase
D5E69_16565	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D5E69_16570	COG0849	cell division
D5E69_16580	COG3118	belongs to the thioredoxin family
D5E69_16585	COG4980	gas vesicle protein
D5E69_16595	COG2309	aminopeptidase activity
D5E69_16600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5E69_16610	COG1674	ftsk spoiiie
D5E69_16615	COG1674	ftsk spoiiie
D5E69_16625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5E69_16630	COG4848	Belongs to the UPF0354 family
D5E69_16635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_16655	COG3104	oligopeptide transport
D5E69_16665	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D5E69_16680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5E69_16685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D5E69_16695	COG0510	thiamine kinase activity
D5E69_16700	COG1523	belongs to the glycosyl hydrolase 13 family
D5E69_16705	COG1597	lipid kinase activity
D5E69_16720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5E69_16730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5E69_16735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5E69_16740	COG1349	DNA-binding transcription factor activity
D5E69_16745	COG1187	pseudouridine synthase activity
D5E69_16750	COG2244	polysaccharide biosynthetic process
D5E69_16755	COG2081	HI0933 family
D5E69_16765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5E69_16770	COG0495	leucyl-tRNA aminoacylation
D5E69_16775	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_16785	COG3290	protein histidine kinase activity
D5E69_16785	COG3829	transcription factor binding
D5E69_16790	COG4297	protein containing double-stranded beta helix domain
D5E69_16795	COG2814	Major facilitator Superfamily
D5E69_16810	COG1242	4 iron, 4 sulfur cluster binding
D5E69_16815	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D5E69_16820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5E69_16825	COG3291	Pkd domain containing protein
D5E69_16825	COG4412	M6 family metalloprotease domain protein
D5E69_16835	COG2267	carboxylic ester hydrolase activity
D5E69_16840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D5E69_16845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D5E69_16875	COG1268	BioY protein
D5E69_16880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_16895	COG3878	Protein conserved in bacteria
D5E69_16905	COG1506	peptidase
D5E69_16910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5E69_16915	COG1116	anion transmembrane transporter activity
D5E69_16920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5E69_16925	COG0494	nUDIX hydrolase
D5E69_16935	COG4824	toxin secretion phage lysis holin
D5E69_16945	COG1253	flavin adenine dinucleotide binding
D5E69_16960	COG1854	S-ribosylhomocysteine lyase activity
D5E69_16965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D5E69_16975	COG1271	oxidase subunit
D5E69_16980	COG1294	oxidase, subunit
D5E69_16995	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_17005	COG4948	Mandelate Racemase Muconate Lactonizing
D5E69_17010	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_17015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D5E69_17020	COG0596	Alpha beta hydrolase
D5E69_17025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D5E69_17030	COG1169	isochorismate synthase
D5E69_17035	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5E69_17040	COG0058	SHG alpha-glucan phosphorylase activity
D5E69_17045	COG0297	glycogen (starch) synthase activity
D5E69_17050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D5E69_17200	COG1285	pathogenesis
D5E69_17205	COG1285	pathogenesis
D5E69_17210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_17210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_17210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_17215	COG1105	Belongs to the carbohydrate kinase PfkB family
D5E69_17220	COG1349	DNA-binding transcription factor activity
D5E69_17225	COG1368	sulfuric ester hydrolase activity
D5E69_17230	COG0561	phosphatase activity
D5E69_17240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D5E69_17245	COG0363	glucosamine-6-phosphate deaminase activity
D5E69_17250	COG0456	acetyltransferase
D5E69_17280	COG1966	Carbon starvation protein
D5E69_17285	COG3279	Response regulator of the LytR AlgR family
D5E69_17290	COG3275	phosphorelay sensor kinase activity
D5E69_17295	COG0697	spore germination
D5E69_17300	COG1902	pentaerythritol trinitrate reductase activity
D5E69_17305	COG0583	DNA-binding transcription factor activity
D5E69_17325	COG2304	oxidoreductase activity
D5E69_17330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_17335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D5E69_17345	COG0367	asparagine synthase
D5E69_17355	COG1979	alcohol dehydrogenase
D5E69_17360	COG2155	Conserved Protein
D5E69_17365	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_17370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5E69_17375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D5E69_17380	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_17385	COG3829	transcription factor binding
D5E69_17395	COG0753	catalase activity
D5E69_17405	COG1012	belongs to the aldehyde dehydrogenase family
D5E69_17410	COG1098	S1 RNA binding domain
D5E69_17420	COG0733	neurotransmitter:sodium symporter activity
D5E69_17425	COG1396	sequence-specific DNA binding
D5E69_17430	COG0436	Aminotransferase
D5E69_17435	COG1522	sequence-specific DNA binding
D5E69_17440	COG2267	carboxylic ester hydrolase activity
D5E69_17445	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D5E69_17450	COG2032	superoxide dismutase activity
D5E69_17460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5E69_17470	COG5018	Exonuclease
D5E69_17475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5E69_17490	COG2111	Na H antiporter
D5E69_17490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5E69_17495	COG2111	Na H antiporter
D5E69_17500	COG1006	Multisubunit Na H antiporter MnhC subunit
D5E69_17505	COG0651	ATP synthesis coupled electron transport
D5E69_17510	COG1863	multisubunit Na H antiporter MnhE subunit
D5E69_17515	COG2212	antiporter activity
D5E69_17525	COG0778	Nitroreductase
D5E69_17530	COG4876	unkown
D5E69_17535	COG2050	protein possibly involved in aromatic compounds catabolism
D5E69_17545	COG2056	Na+-H+ antiporter family
D5E69_17550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5E69_17555	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D5E69_17560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_17565	COG3584	3D domain protein
D5E69_17580	COG2226	methyltransferase
D5E69_17585	COG1252	NADH dehydrogenase
D5E69_17590	COG0492	ferredoxin-NADP+ reductase activity
D5E69_17595	COG0702	epimerase
D5E69_17615	COG0316	Belongs to the HesB IscA family
D5E69_17625	COG1252	NADH dehydrogenase
D5E69_17630	COG4837	Protein of unknown function (DUF1462)
D5E69_17635	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D5E69_17640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5E69_17645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5E69_17650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D5E69_17665	COG0647	UMP catabolic process
D5E69_17670	COG2445	Protein of unknown function DUF86
D5E69_17685	COG4470	Protein conserved in bacteria
D5E69_17695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D5E69_17710	COG0733	neurotransmitter:sodium symporter activity
D5E69_17715	COG1757	Na H antiporter
D5E69_17725	COG0737	Belongs to the 5'-nucleotidase family
D5E69_17730	COG1801	Protein of unknown function DUF72
D5E69_17740	COG0719	Fe-S assembly protein
D5E69_17745	COG0822	iron-sulfur transferase activity
D5E69_17750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D5E69_17755	COG0719	Fe-S assembly protein
D5E69_17760	COG0396	ATPase activity
D5E69_17765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D5E69_17770	COG1464	Belongs to the NlpA lipoprotein family
D5E69_17775	COG2011	ABC-type metal ion transport system permease component
D5E69_17780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5E69_17790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_17795	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D5E69_17805	COG0509	glycine decarboxylation via glycine cleavage system
D5E69_17810	COG1393	Belongs to the ArsC family
D5E69_17815	COG1960	acyl-CoA dehydrogenase activity
D5E69_17820	COG0183	Belongs to the thiolase family
D5E69_17825	COG1024	Enoyl-CoA hydratase
D5E69_17825	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5E69_17840	COG0506	proline dehydrogenase activity
D5E69_17850	COG5577	PFAM Coat F domain
D5E69_17890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_17895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5E69_17900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5E69_17920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_17925	COG1834	amidinotransferase
D5E69_17930	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_17945	COG0655	NAD(P)H dehydrogenase (quinone) activity
D5E69_17955	COG1846	Transcriptional regulator
D5E69_17960	COG1764	response to oxidative stress
D5E69_17975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5E69_17980	COG2514	catechol 2,3-dioxygenase activity
D5E69_17985	COG2259	Doxx family
D5E69_17990	COG1733	regulation of RNA biosynthetic process
D5E69_18000	COG2814	Major facilitator Superfamily
D5E69_18005	COG1846	Transcriptional regulator
D5E69_18020	COG1733	regulation of RNA biosynthetic process
D5E69_18030	COG3403	YqcI/YcgG family
D5E69_18035	COG1280	lysine exporter protein (LysE YggA)
D5E69_18040	COG5577	PFAM Coat F domain
D5E69_18045	COG1376	ErfK ybiS ycfS ynhG family protein
D5E69_18055	COG0460	homoserine dehydrogenase
D5E69_18080	COG2234	aminopeptidase activity
D5E69_18085	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5E69_18085	COG0596	Alpha beta hydrolase
D5E69_18095	COG0300	oxidoreductase activity
D5E69_18125	COG1131	(ABC) transporter
D5E69_18140	COG2076	Multidrug Resistance protein
D5E69_18175	COG0471	metal ion transport
D5E69_18200	COG0697	spore germination
D5E69_18210	COG0346	lactoylglutathione lyase activity
D5E69_18215	COG0346	lactoylglutathione lyase activity
D5E69_18240	COG1733	regulation of RNA biosynthetic process
D5E69_18265	COG1929	Belongs to the glycerate kinase type-1 family
D5E69_18275	COG3835	regulator
D5E69_18285	COG2244	polysaccharide biosynthetic process
D5E69_18335	COG2205	protein histidine kinase activity
D5E69_18360	COG5609	conserved protein (DUF2294)
D5E69_18365	COG0655	NAD(P)H dehydrogenase (quinone) activity
D5E69_18370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5E69_18375	COG0346	lactoylglutathione lyase activity
D5E69_18380	COG1125	glycine betaine transport
D5E69_18380	COG0517	IMP dehydrogenase activity
D5E69_18385	COG1174	glycine betaine transport
D5E69_18400	COG0463	Glycosyl transferase, family 2
D5E69_18410	COG1091	dTDP-4-dehydrorhamnose reductase activity
D5E69_18425	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D5E69_18435	COG0076	glutamate decarboxylase activity
D5E69_18440	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_18455	COG4533	DNA binding
D5E69_18465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_18475	COG0028	Belongs to the TPP enzyme family
D5E69_18495	COG0596	Alpha beta hydrolase
D5E69_18515	COG3764	Sortase (surface protein transpeptidase)
D5E69_18555	COG0572	uridine kinase
D5E69_18560	COG2309	aminopeptidase activity
D5E69_18565	COG1618	nucleotide phosphatase activity, acting on free nucleotides
D5E69_18580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D5E69_18585	COG0557	exoribonuclease II activity
D5E69_18590	COG1647	Serine aminopeptidase, S33
D5E69_18595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D5E69_18600	COG0148	phosphopyruvate hydratase activity
D5E69_18610	COG0149	triose-phosphate isomerase activity
D5E69_18615	COG0126	phosphoglycerate kinase activity
D5E69_18635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D5E69_18650	COG1695	Transcriptional regulator
D5E69_18665	COG3850	Histidine kinase
D5E69_18665	COG5002	protein histidine kinase activity
D5E69_18670	COG0745	RESPONSE REGULATOR receiver
D5E69_18675	COG0671	phosphoesterase, PA-phosphatase related
D5E69_18680	COG0586	Pfam SNARE associated Golgi protein
D5E69_18690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5E69_18695	COG0586	Pfam SNARE associated Golgi protein
D5E69_18710	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_18720	COG1366	Belongs to the anti-sigma-factor antagonist family
D5E69_18720	COG2202	Pas domain
D5E69_18730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D5E69_18755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_18760	COG5002	protein histidine kinase activity
D5E69_18765	COG0745	RESPONSE REGULATOR receiver
D5E69_18790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_18800	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D5E69_18805	COG1660	Displays ATPase and GTPase activities
D5E69_18810	COG1051	belongs to the nudix hydrolase family
D5E69_18840	COG0492	ferredoxin-NADP+ reductase activity
D5E69_18845	COG0457	Tetratricopeptide repeat
D5E69_18850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D5E69_18850	COG0140	phosphoribosyl-ATP diphosphatase activity
D5E69_18855	COG0107	imidazoleglycerol-phosphate synthase activity
D5E69_18865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D5E69_18870	COG0131	Imidazoleglycerol-phosphate dehydratase
D5E69_18875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D5E69_18880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D5E69_18885	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D5E69_18895	COG0110	maltose O-acetyltransferase activity
D5E69_18905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D5E69_18920	COG1950	PFAM Membrane protein of
D5E69_18930	COG3595	metallopeptidase activity
D5E69_18935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D5E69_18940	COG0556	nucleotide-excision repair
D5E69_18945	COG4897	Protein conserved in bacteria
D5E69_18955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5E69_18965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5E69_18970	COG0569	domain protein
D5E69_18980	COG1301	dicarboxylic acid transport
D5E69_18985	COG2059	Chromate
D5E69_18990	COG2059	Chromate
D5E69_18995	COG0405	Gamma-glutamyltransferase
D5E69_19000	COG4608	Belongs to the ABC transporter superfamily
D5E69_19005	COG0444	Belongs to the ABC transporter superfamily
D5E69_19025	COG1522	sequence-specific DNA binding
D5E69_19030	COG1647	Serine aminopeptidase, S33
D5E69_19035	COG0583	DNA-binding transcription factor activity
D5E69_19040	COG2814	Major facilitator Superfamily
D5E69_19045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D5E69_19055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5E69_19065	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5E69_19070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5E69_19075	COG3243	poly(R)-hydroxyalkanoic acid synthase
D5E69_19090	COG0793	Belongs to the peptidase S41A family
D5E69_19090	COG3409	Peptidoglycan-binding domain 1 protein
D5E69_19095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D5E69_19110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5E69_19115	COG2264	protein methyltransferase activity
D5E69_19130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5E69_19140	COG3104	oligopeptide transport
D5E69_19145	COG0739	heme binding
D5E69_19150	COG2177	Part of the ABC transporter FtsEX involved in
D5E69_19155	COG2884	Cell division ATP-binding protein ftsE
D5E69_19165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5E69_19175	COG0653	protein targeting
D5E69_19180	COG1405	negative regulation of cell septum assembly
D5E69_19180	COG3012	SEC-C Motif Domain Protein
D5E69_19205	COG1516	flagellar protein fliS
D5E69_19210	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D5E69_19215	COG1334	flagellar protein FlaG
D5E69_19225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5E69_19230	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D5E69_19235	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D5E69_19245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5E69_19250	COG4786	Flagellar basal body rod
D5E69_19250	COG1256	bacterial-type flagellum assembly
D5E69_19270	COG1040	competence protein
D5E69_19275	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D5E69_19290	COG0697	spore germination
D5E69_19305	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D5E69_19360	COG0346	lactoylglutathione lyase activity
D5E69_19365	COG1227	inorganic diphosphatase activity
D5E69_19370	COG0768	penicillin binding
D5E69_19380	COG1902	pentaerythritol trinitrate reductase activity
D5E69_19385	COG0737	Belongs to the 5'-nucleotidase family
D5E69_19400	COG1464	Belongs to the NlpA lipoprotein family
D5E69_19405	COG2011	ABC-type metal ion transport system permease component
D5E69_19410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5E69_19415	COG0745	RESPONSE REGULATOR receiver
D5E69_19420	COG3850	Histidine kinase
D5E69_19420	COG5002	protein histidine kinase activity
D5E69_19425	COG1136	(ABC) transporter
D5E69_19435	COG0584	glycerophosphoryl diester phosphodiesterase
D5E69_19445	COG0647	UMP catabolic process
D5E69_19455	COG3842	ATPase activity
D5E69_19485	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D5E69_19505	COG1653	transport
D5E69_19510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5E69_19525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5E69_19530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D5E69_19535	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D5E69_19540	COG1473	amidohydrolase
D5E69_19555	COG5002	protein histidine kinase activity
D5E69_19585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5E69_19590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D5E69_19605	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D5E69_19615	COG4187	Peptidase family M20/M25/M40
D5E69_19620	COG1802	Transcriptional regulator
D5E69_19625	COG0277	FAD linked oxidase domain protein
D5E69_19630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5E69_19635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5E69_19640	COG4145	pantothenate transmembrane transporter activity
D5E69_19650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D5E69_19655	COG1802	Transcriptional regulator
D5E69_19660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5E69_19670	COG1301	dicarboxylic acid transport
D5E69_19690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_19690	COG3711	transcriptional antiterminator
D5E69_19695	COG2723	6-phospho-beta-galactosidase activity
D5E69_19705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5E69_19710	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5E69_19720	COG4974	Belongs to the 'phage' integrase family
D5E69_19880	COG3064	Membrane
D5E69_19895	COG0681	Belongs to the peptidase S26 family
D5E69_19905	COG1802	Transcriptional regulator
D5E69_19910	COG2084	Dehydrogenase
D5E69_19920	COG2610	gluconate transmembrane transporter activity
D5E69_19925	COG1802	Transcriptional regulator
D5E69_19930	COG0471	metal ion transport
D5E69_19935	COG0473	3-isopropylmalate dehydrogenase activity
D5E69_19945	COG0395	ABC-type sugar transport system, permease component
D5E69_19955	COG1653	transport
D5E69_19970	COG1404	Belongs to the peptidase S8 family
D5E69_19990	COG2814	Major facilitator Superfamily
D5E69_19995	COG3290	protein histidine kinase activity
D5E69_19995	COG3829	transcription factor binding
D5E69_20000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D5E69_20005	COG1757	Na H antiporter
D5E69_20010	COG2755	lipolytic protein G-D-S-L family
D5E69_20010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5E69_20030	COG0444	Belongs to the ABC transporter superfamily
D5E69_20040	COG0601	transmembrane transport
D5E69_20060	COG0395	ABC-type sugar transport system, permease component
D5E69_20065	COG4209	transmembrane transport
D5E69_20070	COG4753	response regulator
D5E69_20070	COG2207	Transcriptional regulator
D5E69_20075	COG2972	Histidine kinase
D5E69_20090	COG0383	alpha-mannosidase activity
D5E69_20095	COG5578	integral membrane protein
D5E69_20100	COG1940	carbohydrate kinase activity
D5E69_20105	COG2723	6-phospho-beta-galactosidase activity
D5E69_20110	COG1876	peptidase activity
D5E69_20115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_20115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_20115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5E69_20120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5E69_20120	COG3711	transcriptional antiterminator
D5E69_20125	COG1482	cell wall glycoprotein biosynthetic process
D5E69_20135	COG0028	Belongs to the TPP enzyme family
D5E69_20140	COG0069	glutamate synthase activity
D5E69_20150	COG3201	nicotinamide mononucleotide transporter
D5E69_20155	COG1335	isochorismatase
D5E69_20160	COG1056	cytidyltransferase-related domain
D5E69_20160	COG1051	belongs to the nudix hydrolase family
D5E69_20165	COG0702	epimerase
D5E69_20170	COG3829	transcription factor binding
D5E69_20170	COG3290	protein histidine kinase activity
D5E69_20175	COG2851	Citrate transporter
D5E69_20200	COG0596	Alpha beta hydrolase
D5E69_20260	COG0726	polysaccharide deacetylase
D5E69_20265	COG3942	CHAP domain
D5E69_20265	COG1388	LysM domain
D5E69_20315	COG1134	teichoic acid transport
D5E69_20320	COG1682	transport, permease protein
D5E69_20340	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D5E69_20350	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D5E69_20355	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D5E69_20360	COG3562	capsule polysaccharide
D5E69_20370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_20370	COG2190	(PTS) system
D5E69_20370	COG1263	PTS System
D5E69_20375	COG4948	Mandelate Racemase Muconate Lactonizing
D5E69_20380	COG2188	Transcriptional regulator
D5E69_20400	COG0791	NLP P60 protein
D5E69_20400	COG1388	LysM domain
D5E69_20410	COG5002	protein histidine kinase activity
D5E69_20430	COG1263	PTS System
D5E69_20430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_20435	COG0366	Alpha amylase catalytic
D5E69_20465	COG2188	Transcriptional regulator
D5E69_20470	COG2197	response regulator
D5E69_20475	COG4585	Histidine kinase
D5E69_20480	COG1739	Uncharacterized protein family UPF0029
D5E69_20485	COG1316	TRANSCRIPTIONal
D5E69_20490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5E69_20500	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D5E69_20515	COG0438	transferase activity, transferring glycosyl groups
D5E69_20520	COG1368	sulfuric ester hydrolase activity
D5E69_20525	COG1368	sulfuric ester hydrolase activity
D5E69_20530	COG4193	domain, Protein
D5E69_20535	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D5E69_20540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D5E69_20545	COG1215	transferase activity, transferring glycosyl groups
D5E69_20555	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D5E69_20560	COG1682	transport, permease protein
D5E69_20570	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D5E69_20575	COG1388	LysM domain
D5E69_20575	COG0791	NLP P60 protein
D5E69_20580	COG1404	Belongs to the peptidase S8 family
D5E69_20600	COG0010	Belongs to the arginase family
D5E69_20610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D5E69_20615	COG2986	histidine ammonia-lyase
D5E69_20640	COG1840	ABC-type Fe3 transport system, periplasmic component
D5E69_20645	COG3842	ATPase activity
D5E69_20650	COG4149	molybdate abc transporter
D5E69_20655	COG0165	Argininosuccinate lyase
D5E69_20675	COG1785	Belongs to the alkaline phosphatase family
D5E69_20680	COG4715	Zinc finger, swim domain protein
D5E69_20685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5E69_20695	COG0629	single-stranded DNA binding
D5E69_20705	COG1396	sequence-specific DNA binding
D5E69_20725	COG3764	Sortase (surface protein transpeptidase)
D5E69_20740	COG4786	Flagellar basal body rod
D5E69_20745	COG4786	Flagellar basal body rod
D5E69_20750	COG1077	Cell shape determining protein MreB Mrl
D5E69_20755	COG1609	Transcriptional regulator
D5E69_20775	COG0739	heme binding
D5E69_20785	COG2385	sporulation resulting in formation of a cellular spore
D5E69_20805	COG4836	Membrane
D5E69_20820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D5E69_20825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D5E69_20830	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5E69_20835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5E69_20840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5E69_20845	COG0356	it plays a direct role in the translocation of protons across the membrane
D5E69_20860	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D5E69_20865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D5E69_20870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D5E69_20880	COG0698	ribose 5-phosphate isomerase
D5E69_20885	COG0840	transmembrane signaling receptor activity
D5E69_20895	COG1971	Probably functions as a manganese efflux pump
D5E69_20900	COG0246	Mannitol dehydrogenase
D5E69_20915	COG2755	lipolytic protein G-D-S-L family
D5E69_20920	COG0523	cobalamin synthesis protein
D5E69_20930	COG3689	TIGRFAM TIGR03943 family protein
D5E69_20935	COG0701	Predicted permease
D5E69_20945	COG0673	inositol 2-dehydrogenase activity
D5E69_20950	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D5E69_20955	COG0395	ABC-type sugar transport system, permease component
D5E69_20960	COG1175	transmembrane transport
D5E69_20990	COG4753	response regulator
D5E69_20990	COG2207	Transcriptional regulator
D5E69_20995	COG2972	Histidine kinase
D5E69_21010	COG3718	enzyme involved in inositol metabolism
D5E69_21015	COG0009	L-threonylcarbamoyladenylate synthase
D5E69_21030	COG2890	protein-(glutamine-N5) methyltransferase activity
D5E69_21035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D5E69_21045	COG1435	thymidine kinase activity
D5E69_21055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D5E69_21060	COG1494	fructose-1,6-bisphosphatase
D5E69_21065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D5E69_21075	COG0191	fructose-bisphosphate aldolase activity
D5E69_21080	COG2204	response regulator
D5E69_21085	COG4821	SIS domain
D5E69_21090	COG4211	Belongs to the binding-protein-dependent transport system permease family
D5E69_21095	COG1129	ABC transporter
D5E69_21110	COG2801	Transposase and inactivated derivatives
D5E69_21120	COG0504	CTP synthase activity
D5E69_21125	COG3343	RNA polymerase activity
D5E69_21130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_21130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5E69_21130	COG1703	isobutyryl-CoA mutase activity
D5E69_21140	COG1960	acyl-CoA dehydrogenase activity
D5E69_21145	COG1960	acyl-CoA dehydrogenase activity
D5E69_21150	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5E69_21155	COG0183	Belongs to the thiolase family
D5E69_21160	COG2181	nitrate reductase activity
D5E69_21160	COG0247	lactate metabolic process
D5E69_21165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5E69_21200	COG0018	arginyl-trna synthetase
D5E69_21205	COG4506	Protein conserved in bacteria
D5E69_21210	COG0010	Belongs to the arginase family
D5E69_21215	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D5E69_21220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5E69_21230	COG1994	Peptidase M50
D5E69_21240	COG3465	dGTPase activity
D5E69_21265	COG0280	phosphate acetyltransferase
D5E69_21280	COG2363	Small membrane protein
D5E69_21290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D5E69_21300	COG0351	phosphomethylpyrimidine kinase
D5E69_21305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D5E69_21310	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D5E69_21345	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_21360	COG2133	pyrroloquinoline quinone binding
D5E69_21365	COG0561	phosphatase activity
D5E69_21370	COG2031	fatty acid transporter
D5E69_21385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5E69_21390	COG4191	Histidine kinase
D5E69_21400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5E69_21405	COG0156	8-amino-7-oxononanoate synthase activity
D5E69_21415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D5E69_21425	COG2364	Membrane
D5E69_21430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D5E69_21435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5E69_21435	COG0723	plastoquinol--plastocyanin reductase activity
D5E69_21440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5E69_21440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5E69_21450	COG2910	NAD(P)H-binding
D5E69_21455	COG2814	Major facilitator Superfamily
D5E69_21565	COG1028	Short-chain dehydrogenase reductase Sdr
D5E69_21570	COG2610	gluconate transmembrane transporter activity
D5E69_21575	COG0583	DNA-binding transcription factor activity
D5E69_21600	COG1511	domain protein
D5E69_21605	COG0433	COG0433 Predicted ATPase
D5E69_21605	COG1674	ftsk spoiiie
D5E69_21610	COG4499	WXG100 protein secretion system (Wss), protein YukC
D5E69_21615	COG5417	Belongs to the EsaB family
D5E69_21625	COG0745	RESPONSE REGULATOR receiver
D5E69_21630	COG0642	Histidine kinase
D5E69_21635	COG1136	(ABC) transporter
D5E69_21640	COG0577	efflux transmembrane transporter activity
D5E69_21695	COG0443	Heat shock 70 kDa protein
D5E69_21700	COG2214	Heat shock protein DnaJ domain protein
D5E69_21715	COG1263	PTS System
D5E69_21715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_21715	COG2190	(PTS) system
D5E69_21725	COG1846	Transcriptional regulator
D5E69_21730	COG1380	Effector of murein hydrolase LrgA
D5E69_21735	COG1346	cytolysis
D5E69_21755	COG0697	spore germination
D5E69_21760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D5E69_21765	COG2723	6-phospho-beta-galactosidase activity
D5E69_21770	COG1263	PTS System
D5E69_21770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_21770	COG2190	(PTS) system
D5E69_21775	COG3711	transcriptional antiterminator
D5E69_21800	COG4565	transcriptional regulatory protein
D5E69_21805	COG3290	protein histidine kinase activity
D5E69_21810	COG2195	Cleaves the N-terminal amino acid of tripeptides
D5E69_21820	COG1349	DNA-binding transcription factor activity
D5E69_21845	COG1846	Transcriptional regulator
D5E69_21845	COG0456	acetyltransferase
D5E69_21850	COG1621	beta-fructofuranosidase activity
D5E69_21855	COG1621	beta-fructofuranosidase activity
D5E69_21870	COG2207	Transcriptional regulator
D5E69_21870	COG4753	response regulator
D5E69_21875	COG2972	Histidine kinase
D5E69_21880	COG1033	growth of symbiont in host cell
D5E69_21880	COG2409	Drug exporters of the RND superfamily
D5E69_21885	COG1846	Transcriptional regulator
D5E69_21925	COG2135	peptidase activity
D5E69_21930	COG2807	transmembrane transport
D5E69_21935	COG2186	Transcriptional regulator
D5E69_21940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D5E69_21945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D5E69_21950	COG0640	Transcriptional regulator
D5E69_21955	COG0493	'glutamate synthase
D5E69_21955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5E69_21980	COG1136	(ABC) transporter
D5E69_22000	COG1725	Transcriptional regulator
D5E69_22020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5E69_22025	COG0730	response to heat
D5E69_22050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5E69_22055	COG2814	Major facilitator Superfamily
D5E69_22080	COG1914	H( )-stimulated, divalent metal cation uptake system
D5E69_22090	COG0183	Belongs to the thiolase family
D5E69_22095	COG0318	PFAM AMP-dependent synthetase and ligase
D5E69_22100	COG1268	BioY protein
D5E69_22110	COG2723	6-phospho-beta-galactosidase activity
D5E69_22115	COG1263	PTS System
D5E69_22115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_22115	COG2190	(PTS) system
D5E69_22120	COG3711	transcriptional antiterminator
D5E69_22125	COG0697	spore germination
D5E69_22130	COG0789	Transcriptional regulator
D5E69_22145	COG1126	abc transporter atp-binding protein
D5E69_22150	COG0765	amino acid transport
D5E69_22155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5E69_22160	COG3706	GGDEF domain
D5E69_22175	COG3395	kinase activity
D5E69_22180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D5E69_22185	COG0300	oxidoreductase activity
D5E69_22195	COG0450	alkyl hydroperoxide reductase
D5E69_22205	COG1785	Belongs to the alkaline phosphatase family
D5E69_22210	COG1113	amino acid transport
D5E69_22215	COG0672	)-iron permease
D5E69_22225	COG4166	transmembrane transport
D5E69_22230	COG4608	Belongs to the ABC transporter superfamily
D5E69_22235	COG0444	Belongs to the ABC transporter superfamily
D5E69_22240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5E69_22245	COG0601	transmembrane transport
D5E69_22250	COG2362	D-Aminopeptidase
D5E69_22255	COG1522	sequence-specific DNA binding
D5E69_22265	COG0823	Involved in the tonB-independent uptake of proteins
D5E69_22265	COG1506	peptidase
D5E69_22265	COG4946	Tricorn protease homolog
D5E69_22270	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D5E69_22280	COG0277	FAD linked oxidase domain protein
D5E69_22290	COG1263	PTS System
D5E69_22290	COG2190	(PTS) system
D5E69_22290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_22295	COG2723	6-phospho-beta-galactosidase activity
D5E69_22300	COG3711	transcriptional antiterminator
D5E69_22305	COG4682	membrane
D5E69_22315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5E69_22330	COG3142	Participates in the control of copper homeostasis
D5E69_22345	COG1187	pseudouridine synthase activity
D5E69_22350	COG1204	response to ionizing radiation
D5E69_22380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D5E69_22390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5E69_22395	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5E69_22400	COG4853	Protein conserved in bacteria
D5E69_22405	COG4863	YycH protein
D5E69_22410	COG5002	protein histidine kinase activity
D5E69_22415	COG0745	RESPONSE REGULATOR receiver
D5E69_22420	COG0739	heme binding
D5E69_22455	COG1132	(ABC) transporter
D5E69_22460	COG0305	Participates in initiation and elongation during chromosome replication
D5E69_22465	COG0359	binds to the 23S rRNA
D5E69_22470	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D5E69_22475	COG4241	membrane
D5E69_22480	COG0840	transmembrane signaling receptor activity
D5E69_22490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D5E69_22495	COG0629	single-stranded DNA binding
D5E69_22500	COG0360	Binds together with S18 to 16S ribosomal RNA
D5E69_22505	COG0012	GTP binding
D5E69_22510	COG4481	Protein conserved in bacteria
D5E69_22515	COG0668	transmembrane transport
D5E69_22530	COG1811	Na channel or pump
D5E69_22535	COG1475	DNA binding
D5E69_22540	COG1192	Involved in chromosome partitioning
D5E69_22545	COG1475	DNA binding
D5E69_22550	COG0357	Ribosomal RNA small subunit methyltransferase G
D5E69_22560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5E69_22565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5E69_22570	COG1847	R3H domain protein
D5E69_22580	COG0594	ribonuclease P activity
D5E69_22585	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D5E69_22605	COG2247	cell wall binding repeat
D5E69_22605	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5E69_22740	COG1793	dna ligase
D5E69_22755	COG1923	regulation of RNA biosynthetic process
D5E69_22765	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D5E69_22770	COG2309	aminopeptidase activity
D5E69_22830	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D5E69_22845	COG1609	Transcriptional regulator
D5E69_22850	COG1263	PTS System
D5E69_22850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5E69_22855	COG1621	beta-fructofuranosidase activity
D5E69_22860	COG3596	GTP binding
D5E69_22875	COG2205	protein histidine kinase activity
D5E69_22880	COG0745	RESPONSE REGULATOR receiver
D5E69_22885	COG1388	LysM domain
D5E69_22980	COG0825	malonyl-CoA metabolic process
D5E69_23005	COG0629	single-stranded DNA binding
D5E69_23225	COG4712	double-strand break repair protein
D5E69_23285	COG0739	heme binding
D5E69_23305	COG5001	Diguanylate cyclase
D5E69_23305	COG4251	negative regulation of phosphorylation
D5E69_23305	COG3706	GGDEF domain
D5E69_23305	COG2203	Gaf domain
D5E69_23315	COG4974	Belongs to the 'phage' integrase family