locus-tag	class	description
HW576_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW576_00010	COG0592	DNA-directed DNA polymerase activity
HW576_00015	COG2501	S4 domain
HW576_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW576_00025	COG0187	DNA topoisomerase II activity
HW576_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW576_00065	COG0517	IMP dehydrogenase activity
HW576_00065	COG0516	GMP reductase activity
HW576_00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HW576_00095	COG1428	Deoxynucleoside kinase
HW576_00100	COG1428	Deoxynucleoside kinase
HW576_00105	COG1388	LysM domain
HW576_00105	COG3858	chitin binding
HW576_00110	COG1335	isochorismatase
HW576_00115	COG0590	tRNA wobble adenosine to inosine editing
HW576_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW576_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HW576_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HW576_00240	COG1982	Orn Lys Arg decarboxylase major
HW576_00245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW576_00250	COG3870	Protein conserved in bacteria
HW576_00255	COG0470	DNA polymerase III
HW576_00260	COG1774	PSP1 C-terminal conserved region
HW576_00265	COG4467	Involved in initiation control of chromosome replication
HW576_00270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HW576_00275	COG2827	Endonuclease containing a URI domain
HW576_00280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HW576_00285	COG2002	toxin-antitoxin pair type II binding
HW576_00295	COG0084	hydrolase, TatD family'
HW576_00305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW576_00315	COG4466	Protein conserved in bacteria
HW576_00330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW576_00335	COG0251	oxidation-reduction process
HW576_00340	COG2088	sporulation resulting in formation of a cellular spore
HW576_00345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW576_00360	COG0193	aminoacyl-tRNA hydrolase activity
HW576_00370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HW576_00375	COG2002	toxin-antitoxin pair type II binding
HW576_00380	COG2244	polysaccharide biosynthetic process
HW576_00385	COG3956	TIGRFAM MazG family protein
HW576_00390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HW576_00405	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HW576_00410	COG1098	S1 RNA binding domain
HW576_00430	COG2304	oxidoreductase activity
HW576_00435	COG0515	serine threonine protein kinase
HW576_00440	COG0037	tRNA processing
HW576_00450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW576_00455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HW576_00460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HW576_00465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW576_00470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW576_00475	COG0512	Glutamine amidotransferase of anthranilate synthase
HW576_00480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW576_00485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW576_00490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HW576_00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HW576_00520	COG3880	PFAM UvrB UvrC protein
HW576_00525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HW576_00530	COG0542	response to heat
HW576_00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HW576_00540	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HW576_00545	COG4956	integral membrane protein (PIN domain superfamily)
HW576_00550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HW576_00560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HW576_00565	COG1045	serine acetyltransferase
HW576_00570	COG0215	cysteine-tRNA ligase activity
HW576_00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW576_00585	COG3688	RNA-binding protein containing a PIN domain
HW576_00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW576_00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW576_00605	COG0250	Participates in transcription elongation, termination and antitermination
HW576_00610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HW576_00615	COG0081	regulation of translation
HW576_00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HW576_00625	COG0222	ribosome binding
HW576_00630	COG2813	Specifically methylates the guanine in position
HW576_00635	COG0085	RNA polymerase activity
HW576_00645	COG1358	cellular component organization or biogenesis
HW576_00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HW576_00655	COG0049	tRNA binding
HW576_00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HW576_00670	COG0051	transcription antitermination factor activity, RNA binding
HW576_00675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HW576_00680	COG0088	Forms part of the polypeptide exit tunnel
HW576_00685	COG0089	rRNA binding
HW576_00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HW576_00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HW576_00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HW576_00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HW576_00715	COG0255	Belongs to the universal ribosomal protein uL29 family
HW576_00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HW576_00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HW576_00740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW576_00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HW576_00760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HW576_00765	COG1841	ribosomal large subunit assembly
HW576_00775	COG0201	protein transport
HW576_00780	COG0563	adenylate kinase activity
HW576_00785	COG0024	Methionine aminopeptidase
HW576_00790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW576_00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW576_00800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HW576_00810	COG0202	RNA polymerase activity
HW576_00815	COG0203	ribosomal protein L17
HW576_00820	COG1122	ATPase activity
HW576_00825	COG1122	ATPase activity
HW576_00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HW576_00835	COG0101	tRNA pseudouridine synthase activity
HW576_00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HW576_00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW576_00860	COG0489	protein tyrosine kinase activity
HW576_00865	COG0583	DNA-binding transcription factor activity
HW576_00875	COG2194	sulfuric ester hydrolase activity
HW576_00880	COG0726	polysaccharide deacetylase
HW576_00960	COG1595	DNA-templated transcription, initiation
HW576_00965	COG5662	AntiSigma factor
HW576_00970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HW576_00980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW576_00985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW576_00995	COG1388	LysM domain
HW576_00995	COG3103	Sh3 type 3 domain protein
HW576_00995	COG0791	NLP P60 protein
HW576_01000	COG2213	PTS system mannitol-specific
HW576_01000	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW576_01005	COG3711	transcriptional antiterminator
HW576_01010	COG0246	Mannitol dehydrogenase
HW576_01020	COG1376	ErfK ybiS ycfS ynhG family protein
HW576_01025	COG1970	mechanosensitive ion channel activity
HW576_01030	COG1368	sulfuric ester hydrolase activity
HW576_01050	COG1177	transmembrane transport
HW576_01055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW576_01065	COG0745	RESPONSE REGULATOR receiver
HW576_01070	COG5002	protein histidine kinase activity
HW576_01085	COG3976	FMN-binding domain protein
HW576_01085	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HW576_01090	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW576_01095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW576_01100	COG0513	Belongs to the DEAD box helicase family
HW576_01105	COG4294	response to UV
HW576_01110	COG0705	Rhomboid family
HW576_01115	COG0736	holo-[acyl-carrier-protein] synthase activity
HW576_01120	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HW576_01125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HW576_01130	COG0864	Transcriptional regulator
HW576_01135	COG2337	Toxic component of a toxin-antitoxin (TA) module
HW576_01140	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_01145	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_01150	COG2172	sigma factor antagonist activity
HW576_01155	COG2208	phosphoserine phosphatase activity
HW576_01160	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_01170	COG1191	sigma factor activity
HW576_01175	COG2208	phosphoserine phosphatase activity
HW576_01180	COG2183	response to ionizing radiation
HW576_01275	COG0802	atpase or kinase
HW576_01280	COG1214	PFAM Peptidase M22, glycoprotease
HW576_01285	COG0456	acetyltransferase
HW576_01295	COG0488	(ABC) transporter
HW576_01300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HW576_01305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW576_01310	COG0805	protein transport
HW576_01320	COG1266	CAAX protease self-immunity
HW576_01325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HW576_01335	COG0714	Associated with various cellular activities
HW576_01340	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HW576_01345	COG1305	Transglutaminase-like
HW576_01350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HW576_01350	COG0519	Catalyzes the synthesis of GMP from XMP
HW576_01355	COG2252	PERMEase
HW576_01410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HW576_01415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HW576_01420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW576_01425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HW576_01430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW576_01435	COG0047	phosphoribosylformylglycinamidine synthase activity
HW576_01440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW576_01445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HW576_01450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HW576_01455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HW576_01460	COG0138	bifunctional purine biosynthesis protein purh
HW576_01465	COG0151	Belongs to the GarS family
HW576_01475	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HW576_01480	COG4496	protein, YerC YecD
HW576_01485	COG0423	glycine-tRNA ligase activity
HW576_01495	COG0210	DNA helicase
HW576_01505	COG4851	CamS sex pheromone cAM373 precursor
HW576_01515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW576_01520	COG0154	amidase activity
HW576_01530	COG1597	lipid kinase activity
HW576_01540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_01550	COG0166	Belongs to the GPI family
HW576_01555	COG1744	ABC transporter substrate-binding protein PnrA-like
HW576_01560	COG3852	Histidine kinase
HW576_01565	COG0024	Methionine aminopeptidase
HW576_01570	COG2706	6-phosphogluconolactonase activity
HW576_01580	COG0789	Transcriptional regulator
HW576_01580	COG4978	Transcriptional regulator
HW576_01585	COG2814	Major facilitator Superfamily
HW576_01595	COG1876	peptidase activity
HW576_01600	COG1126	abc transporter atp-binding protein
HW576_01605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW576_01610	COG0765	amino acid transport
HW576_01615	COG0765	amino acid transport
HW576_01620	COG1113	amino acid transport
HW576_01625	COG2733	membrane
HW576_01630	COG3212	peptidase
HW576_01635	COG3212	peptidase
HW576_01640	COG3850	Histidine kinase
HW576_01640	COG5002	protein histidine kinase activity
HW576_01645	COG0745	RESPONSE REGULATOR receiver
HW576_01650	COG2205	protein histidine kinase activity
HW576_01655	COG0745	RESPONSE REGULATOR receiver
HW576_01660	COG2311	Membrane
HW576_01675	COG0671	phosphoesterase, PA-phosphatase related
HW576_01680	COG1764	response to oxidative stress
HW576_01685	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HW576_01695	COG2259	Doxx family
HW576_01700	COG0693	protein deglycase activity
HW576_01710	COG2318	DinB family
HW576_01720	COG1115	amino acid carrier protein
HW576_01735	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HW576_01740	COG0598	Magnesium transport protein CorA
HW576_01745	COG3290	protein histidine kinase activity
HW576_01750	COG4565	transcriptional regulatory protein
HW576_01765	COG4191	Histidine kinase
HW576_01770	COG0513	Belongs to the DEAD box helicase family
HW576_01790	COG4842	Belongs to the WXG100 family
HW576_01795	COG5417	Belongs to the EsaB family
HW576_01800	COG4499	WXG100 protein secretion system (Wss), protein YukC
HW576_01805	COG1674	ftsk spoiiie
HW576_01805	COG0433	COG0433 Predicted ATPase
HW576_01810	COG1511	domain protein
HW576_01825	COG2356	endonuclease I
HW576_01835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW576_01850	COG0488	(ABC) transporter
HW576_01860	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HW576_01870	COG1959	2 iron, 2 sulfur cluster binding
HW576_01875	COG1017	nitric oxide dioxygenase activity
HW576_01875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW576_01885	COG0693	protein deglycase activity
HW576_01890	COG2340	Cysteine-rich secretory protein family
HW576_01895	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HW576_01900	COG4840	Belongs to the UPF0435 family
HW576_01905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW576_01910	COG4980	gas vesicle protein
HW576_01915	COG1295	ribonuclease BN
HW576_01920	COG2217	Heavy metal translocating P-type atpase
HW576_01930	COG0640	Transcriptional regulator
HW576_01940	COG0477	Major facilitator Superfamily
HW576_01950	COG3479	Phenolic acid decarboxylase
HW576_01960	COG3871	stress protein (general stress protein 26)
HW576_01965	COG0387	Pfam Sodium calcium exchanger
HW576_01975	COG0535	radical SAM domain protein
HW576_01995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW576_02005	COG1113	amino acid transport
HW576_02010	COG5002	protein histidine kinase activity
HW576_02030	COG1090	epimerase
HW576_02040	COG4221	oxidoreductase activity
HW576_02060	COG1988	membrane-bound metal-dependent
HW576_02065	COG1194	a g-specific adenine glycosylase
HW576_02075	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_02090	COG3557	Belongs to the UPF0374 family
HW576_02095	COG1132	(ABC) transporter
HW576_02100	COG4129	membrane
HW576_02110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW576_02115	COG4555	ABC transporter
HW576_02135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW576_02140	COG0735	belongs to the Fur family
HW576_02250	COG4974	Belongs to the 'phage' integrase family
HW576_02310	COG0582	viral genome integration into host DNA
HW576_02345	COG3382	B3 4 domain protein
HW576_02360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW576_02365	COG2766	serine protein kinase
HW576_02380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW576_02395	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HW576_02405	COG1968	undecaprenyl-diphosphatase activity
HW576_02410	COG1301	dicarboxylic acid transport
HW576_02420	COG0586	Pfam SNARE associated Golgi protein
HW576_02425	COG2217	Heavy metal translocating P-type atpase
HW576_02430	COG0531	amino acid
HW576_02445	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HW576_02450	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HW576_02455	COG3842	ATPase activity
HW576_02460	COG1175	transmembrane transport
HW576_02470	COG1653	transport
HW576_02475	COG0584	glycerophosphoryl diester phosphodiesterase
HW576_02490	COG4948	Mandelate Racemase Muconate Lactonizing
HW576_02535	COG3583	domain protein
HW576_02535	COG3584	3D domain protein
HW576_02540	COG1876	peptidase activity
HW576_02550	COG3103	Sh3 type 3 domain protein
HW576_02560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_02560	COG0456	acetyltransferase
HW576_02565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW576_02585	COG1609	Transcriptional regulator
HW576_02590	COG2814	Major facilitator Superfamily
HW576_02595	COG0673	inositol 2-dehydrogenase activity
HW576_02620	COG1609	Transcriptional regulator
HW576_02635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_02640	COG1522	sequence-specific DNA binding
HW576_02655	COG2814	Major facilitator Superfamily
HW576_02660	COG1309	transcriptional regulator
HW576_02665	COG1187	pseudouridine synthase activity
HW576_02680	COG1942	4-Oxalocrotonate Tautomerase
HW576_02685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW576_02690	COG0747	negative chemotaxis
HW576_02710	COG0084	hydrolase, TatD family'
HW576_02715	COG2962	Rard protein
HW576_02725	COG0628	permease
HW576_02740	COG0604	alcohol dehydrogenase
HW576_02745	COG1620	l-lactate permease
HW576_02755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW576_02760	COG0840	transmembrane signaling receptor activity
HW576_02765	COG0564	pseudouridine synthase activity
HW576_02775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW576_02780	COG1376	ErfK ybiS ycfS ynhG family protein
HW576_02785	COG3153	acetyltransferase
HW576_02785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW576_02790	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HW576_02795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HW576_02805	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW576_02810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW576_02815	COG1268	BioY protein
HW576_02825	COG2719	SpoVR family
HW576_02835	COG1959	2 iron, 2 sulfur cluster binding
HW576_02840	COG0604	alcohol dehydrogenase
HW576_02850	COG1126	abc transporter atp-binding protein
HW576_02855	COG0765	amino acid transport
HW576_02860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW576_02865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW576_02870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW576_02880	COG0352	thiamine-phosphate diphosphorylase activity
HW576_02885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW576_02900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW576_02905	COG0351	phosphomethylpyrimidine kinase
HW576_02920	COG0702	epimerase
HW576_02925	COG1253	flavin adenine dinucleotide binding
HW576_02940	COG3842	ATPase activity
HW576_02945	COG2508	Transcriptional regulator
HW576_02960	COG0189	ligase activity
HW576_02965	COG0189	ligase activity
HW576_02975	COG3679	Belongs to the UPF0342 family
HW576_02980	COG0561	phosphatase activity
HW576_02990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW576_02995	COG0318	PFAM AMP-dependent synthetase and ligase
HW576_03000	COG1024	Enoyl-CoA hydratase
HW576_03015	COG4152	abc transporter atp-binding protein
HW576_03020	COG1668	transmembrane transport
HW576_03025	COG3481	metal-dependent phosphohydrolase, HD sub domain
HW576_03035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW576_03060	COG1846	Transcriptional regulator
HW576_03075	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HW576_03080	COG1695	Transcriptional regulator
HW576_03085	COG2153	protein acetylation
HW576_03090	COG2755	lipolytic protein G-D-S-L family
HW576_03090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HW576_03095	COG0537	adenosine 5'-monophosphoramidase activity
HW576_03100	COG1131	(ABC) transporter
HW576_03105	COG4473	ABC transporter
HW576_03115	COG1473	amidohydrolase
HW576_03120	COG0671	phosphoesterase, PA-phosphatase related
HW576_03125	COG3069	C4-dicarboxylate transmembrane transporter activity
HW576_03130	COG2329	Antibiotic biosynthesis monooxygenase
HW576_03135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW576_03140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HW576_03155	COG1309	transcriptional regulator
HW576_03170	COG2972	Histidine kinase
HW576_03185	COG1234	tRNA 3'-trailer cleavage
HW576_03190	COG0095	Lipoate-protein ligase
HW576_03195	COG0318	PFAM AMP-dependent synthetase and ligase
HW576_03200	COG1024	Enoyl-CoA hydratase
HW576_03315	COG0501	Belongs to the peptidase M48B family
HW576_03320	COG2224	Isocitrate lyase
HW576_03330	COG1506	peptidase
HW576_03330	COG4946	Tricorn protease homolog
HW576_03330	COG0823	Involved in the tonB-independent uptake of proteins
HW576_03335	COG0398	Pfam SNARE associated Golgi protein
HW576_03340	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_03345	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HW576_03350	COG1074	ATP-dependent DNA helicase activity
HW576_03355	COG0420	3'-5' exonuclease activity
HW576_03360	COG0419	ATPase involved in DNA repair
HW576_03365	COG1403	HNH endonuclease
HW576_03400	COG2311	Membrane
HW576_03415	COG0367	asparagine synthase
HW576_03430	COG1562	ergosterol biosynthetic process
HW576_03440	COG0366	Alpha amylase catalytic
HW576_03440	COG1874	Beta-galactosidase
HW576_03445	COG1609	Transcriptional regulator
HW576_03450	COG1012	belongs to the aldehyde dehydrogenase family
HW576_03455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW576_03460	COG4187	Peptidase family M20/M25/M40
HW576_03465	COG0833	amino acid
HW576_03470	COG3829	transcription factor binding
HW576_03475	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_03480	COG1666	GTP binding
HW576_03485	COG2996	Protein conserved in bacteria
HW576_03495	COG1307	EDD domain protein, DegV family
HW576_03500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_03515	COG0561	phosphatase activity
HW576_03520	COG2151	metal-sulfur cluster biosynthetic enzyme
HW576_03525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW576_03530	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HW576_03535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HW576_03540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HW576_03560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HW576_03575	COG0542	response to heat
HW576_03590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HW576_03595	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HW576_03600	COG2084	Dehydrogenase
HW576_03610	COG2267	carboxylic ester hydrolase activity
HW576_03630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW576_03635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW576_03640	COG5504	Zn-dependent protease
HW576_03645	COG0444	Belongs to the ABC transporter superfamily
HW576_03650	COG4608	Belongs to the ABC transporter superfamily
HW576_03660	COG0601	transmembrane transport
HW576_03675	COG0180	Tryptophanyl-tRNA synthetase
HW576_03680	COG4166	transmembrane transport
HW576_03685	COG0601	transmembrane transport
HW576_03690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW576_03695	COG0444	Belongs to the ABC transporter superfamily
HW576_03700	COG4608	Belongs to the ABC transporter superfamily
HW576_03705	COG0456	acetyltransferase
HW576_03710	COG1113	amino acid transport
HW576_03715	COG0531	amino acid
HW576_03720	COG1393	Belongs to the ArsC family
HW576_03725	COG0583	DNA-binding transcription factor activity
HW576_03740	COG0861	Integral membrane protein TerC family
HW576_03750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW576_03760	COG1164	Oligoendopeptidase f
HW576_03775	COG2346	COG2346, Truncated hemoglobins
HW576_03780	COG0741	lytic transglycosylase activity
HW576_03785	COG4116	CYTH
HW576_03795	COG2357	RelA SpoT domain protein
HW576_03805	COG0564	pseudouridine synthase activity
HW576_03815	COG2239	Acts as a magnesium transporter
HW576_03820	COG0569	domain protein
HW576_03820	COG0475	glutathione-regulated potassium exporter activity
HW576_03880	COG0210	DNA helicase
HW576_03890	COG2323	membrane
HW576_03895	COG2153	protein acetylation
HW576_03905	COG2382	esterase
HW576_03915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HW576_03925	COG1737	Transcriptional regulator
HW576_03930	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HW576_03935	COG1070	Carbohydrate kinase
HW576_03940	COG1953	Uracil, thiamine, allantoin
HW576_03960	COG1522	sequence-specific DNA binding
HW576_03970	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HW576_03985	COG3142	Participates in the control of copper homeostasis
HW576_03990	COG1113	amino acid transport
HW576_04000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW576_04005	COG1309	transcriptional regulator
HW576_04010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW576_04010	COG3711	transcriptional antiterminator
HW576_04015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW576_04020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW576_04025	COG1447	Phosphotransferase system cellobiose-specific component IIA
HW576_04030	COG1486	melibiose metabolic process
HW576_04035	COG3275	phosphorelay sensor kinase activity
HW576_04040	COG3279	Response regulator of the LytR AlgR family
HW576_04050	COG1346	cytolysis
HW576_04060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW576_04065	COG0243	molybdopterin cofactor binding
HW576_04070	COG2223	nitrite transmembrane transporter activity
HW576_04075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW576_04090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW576_04105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HW576_04105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW576_04115	COG3527	Alpha-acetolactate decarboxylase
HW576_04120	COG0028	Belongs to the TPP enzyme family
HW576_04130	COG4895	conserved protein (DUF2196)
HW576_04140	COG1733	regulation of RNA biosynthetic process
HW576_04145	COG2814	Major facilitator Superfamily
HW576_04150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_04170	COG3052	prosthetic group binding
HW576_04185	COG0784	Response regulator, receiver
HW576_04190	COG4191	Histidine kinase
HW576_04195	COG2066	Belongs to the glutaminase family
HW576_04200	COG1115	amino acid carrier protein
HW576_04205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW576_04220	COG0531	amino acid
HW576_04230	COG1607	acyl-coa hydrolase
HW576_04235	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HW576_04250	COG0390	transport system, permease component
HW576_04255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HW576_04270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW576_04275	COG1136	(ABC) transporter
HW576_04280	COG0577	efflux transmembrane transporter activity
HW576_04290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HW576_04310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HW576_04315	COG0833	amino acid
HW576_04325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HW576_04330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW576_04340	COG0861	Integral membrane protein TerC family
HW576_04350	COG1301	dicarboxylic acid transport
HW576_04355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW576_04360	COG3290	protein histidine kinase activity
HW576_04400	COG1476	TRANSCRIPTIONal
HW576_04410	COG1368	sulfuric ester hydrolase activity
HW576_04425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_04430	COG2040	homocysteine
HW576_04435	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW576_04445	COG2851	Citrate transporter
HW576_04450	COG3290	protein histidine kinase activity
HW576_04455	COG4565	transcriptional regulatory protein
HW576_04460	COG3181	Tripartite tricarboxylate transporter family receptor
HW576_04470	COG0583	DNA-binding transcription factor activity
HW576_04475	COG3180	Ammonia monooxygenase
HW576_04480	COG2226	methyltransferase
HW576_04490	COG0517	IMP dehydrogenase activity
HW576_04490	COG4175	Glycine betaine
HW576_04495	COG2113	Glycine betaine
HW576_04500	COG1309	transcriptional regulator
HW576_04505	COG1012	belongs to the aldehyde dehydrogenase family
HW576_04520	COG0531	amino acid
HW576_04525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW576_04530	COG1464	Belongs to the NlpA lipoprotein family
HW576_04535	COG2011	ABC-type metal ion transport system permease component
HW576_04540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW576_04555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_04565	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HW576_04570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW576_04575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW576_04600	COG1737	Transcriptional regulator
HW576_04605	COG1263	PTS System
HW576_04605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW576_04615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW576_04620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HW576_04625	COG1116	anion transmembrane transporter activity
HW576_04630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW576_04635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW576_04645	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HW576_04650	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HW576_04655	COG1733	regulation of RNA biosynthetic process
HW576_04690	COG1511	domain protein
HW576_04700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HW576_04705	COG1733	regulation of RNA biosynthetic process
HW576_04715	COG1132	(ABC) transporter
HW576_04720	COG1132	(ABC) transporter
HW576_04730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW576_04735	COG3162	membrane
HW576_04745	COG1414	Transcriptional regulator
HW576_04750	COG0656	L-ascorbic acid biosynthetic process
HW576_04755	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HW576_04760	COG1846	Transcriptional regulator
HW576_04765	COG1566	PFAM secretion protein HlyD family protein
HW576_04770	COG2814	Major facilitator Superfamily
HW576_04775	COG0655	NAD(P)H dehydrogenase (quinone) activity
HW576_04790	COG1609	Transcriptional regulator
HW576_04795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW576_04805	COG1129	ABC transporter
HW576_04810	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW576_04815	COG1879	ABC-type sugar transport system periplasmic component
HW576_04820	COG3584	3D domain protein
HW576_04820	COG1388	LysM domain
HW576_04825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW576_04830	COG1653	transport
HW576_04875	COG0745	RESPONSE REGULATOR receiver
HW576_04880	COG5002	protein histidine kinase activity
HW576_04890	COG2267	carboxylic ester hydrolase activity
HW576_04915	COG0402	S-adenosylhomocysteine deaminase activity
HW576_04925	COG2252	PERMEase
HW576_04935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW576_04940	COG1012	belongs to the aldehyde dehydrogenase family
HW576_04950	COG0710	3-dehydroquinate dehydratase activity
HW576_04960	COG1263	PTS System
HW576_04960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW576_04965	COG0366	Alpha amylase catalytic
HW576_04970	COG2188	Transcriptional regulator
HW576_04975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HW576_04980	COG1984	allophanate hydrolase subunit 2
HW576_04985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HW576_04990	COG1914	H( )-stimulated, divalent metal cation uptake system
HW576_04995	COG1272	protein, Hemolysin III
HW576_05010	COG0778	Nitroreductase
HW576_05015	COG0628	permease
HW576_05040	COG2271	Major facilitator Superfamily
HW576_05045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW576_05050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW576_05055	COG1012	belongs to the aldehyde dehydrogenase family
HW576_05070	COG0439	Biotin carboxylase
HW576_05085	COG0531	amino acid
HW576_05090	COG0402	S-adenosylhomocysteine deaminase activity
HW576_05095	COG1278	Cold shock
HW576_05100	COG2910	NAD(P)H-binding
HW576_05105	COG0673	inositol 2-dehydrogenase activity
HW576_05110	COG0450	alkyl hydroperoxide reductase
HW576_05115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW576_05145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW576_05230	COG1649	PFAM Uncharacterised BCR, COG1649
HW576_05235	COG1737	Transcriptional regulator
HW576_05255	COG1486	melibiose metabolic process
HW576_05265	COG1447	Phosphotransferase system cellobiose-specific component IIA
HW576_05275	COG2971	BadF BadG BcrA BcrD
HW576_05280	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HW576_05285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW576_05295	COG3037	sugar-specific permease SgaT UlaA
HW576_05300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW576_05300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HW576_05310	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HW576_05325	COG1376	ErfK ybiS ycfS ynhG family protein
HW576_05330	COG4106	trans-aconitate 2-methyltransferase activity
HW576_05335	COG0583	DNA-binding transcription factor activity
HW576_05345	COG0667	Aldo Keto reductase
HW576_05360	COG0154	amidase activity
HW576_05365	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW576_05370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW576_05410	COG2200	EAL domain
HW576_05410	COG2199	diguanylate cyclase activity
HW576_05420	COG1733	regulation of RNA biosynthetic process
HW576_05435	COG0385	Bile acid
HW576_05445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW576_05450	COG4191	Histidine kinase
HW576_05455	COG0784	Response regulator, receiver
HW576_05470	COG0791	NLP P60 protein
HW576_05470	COG1388	LysM domain
HW576_05480	COG2385	sporulation resulting in formation of a cellular spore
HW576_05485	COG0656	L-ascorbic acid biosynthetic process
HW576_05505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW576_05510	COG4948	Mandelate Racemase Muconate Lactonizing
HW576_05545	COG0477	Major facilitator Superfamily
HW576_05550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW576_05560	COG0640	Transcriptional regulator
HW576_05565	COG5658	integral membrane protein
HW576_05585	COG5001	Diguanylate cyclase
HW576_05585	COG3300	MHYT domain
HW576_05590	COG0302	gtp cyclohydrolase
HW576_05610	COG0531	amino acid
HW576_05630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW576_05665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HW576_05670	COG1396	sequence-specific DNA binding
HW576_05675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW576_05680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW576_05690	COG4464	protein tyrosine phosphatase activity
HW576_05695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW576_05700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HW576_05705	COG1442	glycosyl transferase family 8
HW576_05735	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HW576_05740	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HW576_05740	COG0517	IMP dehydrogenase activity
HW576_05745	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HW576_05750	COG3944	biosynthesis protein
HW576_05755	COG0489	protein tyrosine kinase activity
HW576_05765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW576_05770	COG4464	protein tyrosine phosphatase activity
HW576_05785	COG0028	Belongs to the TPP enzyme family
HW576_05790	COG0069	glutamate synthase activity
HW576_05800	COG2084	Dehydrogenase
HW576_05830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW576_05835	COG2146	nitrite reductase [NAD(P)H] activity
HW576_05845	COG2116	formate transmembrane transporter activity
HW576_05855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW576_05860	COG4975	Glucose uptake
HW576_05880	COG0534	Mate efflux family protein
HW576_05890	COG1316	TRANSCRIPTIONal
HW576_05900	COG0598	Magnesium transport protein CorA
HW576_05905	COG1404	Belongs to the peptidase S8 family
HW576_05925	COG4821	SIS domain
HW576_05930	COG2188	Transcriptional regulator
HW576_05935	COG0363	glucosamine-6-phosphate deaminase activity
HW576_05940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW576_05945	COG2190	(PTS) system
HW576_05945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW576_05945	COG1263	PTS System
HW576_05950	COG1811	Na channel or pump
HW576_05955	COG3961	Belongs to the TPP enzyme family
HW576_05990	COG1131	(ABC) transporter
HW576_05995	COG1253	flavin adenine dinucleotide binding
HW576_06000	COG0789	Transcriptional regulator
HW576_06010	COG0346	lactoylglutathione lyase activity
HW576_06015	COG2105	PFAM AIG2 family protein
HW576_06015	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HW576_06060	COG0456	acetyltransferase
HW576_06065	COG1473	amidohydrolase
HW576_06075	COG4187	Peptidase family M20/M25/M40
HW576_06090	COG0456	acetyltransferase
HW576_06090	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HW576_06110	COG2252	PERMEase
HW576_06120	COG3279	Response regulator of the LytR AlgR family
HW576_06125	COG4555	ABC transporter
HW576_06130	COG1668	transmembrane transport
HW576_06140	COG0789	Transcriptional regulator
HW576_06145	COG1846	Transcriptional regulator
HW576_06150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW576_06150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW576_06170	COG1785	Belongs to the alkaline phosphatase family
HW576_06175	COG3279	Response regulator of the LytR AlgR family
HW576_06180	COG0784	Response regulator, receiver
HW576_06180	COG2205	protein histidine kinase activity
HW576_06185	COG0861	Integral membrane protein TerC family
HW576_06190	COG1191	sigma factor activity
HW576_06220	COG3243	poly(R)-hydroxyalkanoic acid synthase
HW576_06230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW576_06250	COG2186	Transcriptional regulator
HW576_06255	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HW576_06265	COG0247	lactate metabolic process
HW576_06270	COG1139	Iron-sulfur cluster binding protein
HW576_06275	COG1556	Lactate utilization protein
HW576_06280	COG5002	protein histidine kinase activity
HW576_06285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW576_06295	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HW576_06300	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HW576_06305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW576_06310	COG0436	Aminotransferase
HW576_06315	COG1850	ribulose-bisphosphate carboxylase activity
HW576_06320	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HW576_06325	COG0235	Class ii aldolase
HW576_06330	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HW576_06340	COG1129	ABC transporter
HW576_06345	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW576_06370	COG1846	Transcriptional regulator
HW576_06380	COG4191	Histidine kinase
HW576_06390	COG0542	response to heat
HW576_06405	COG0300	oxidoreductase activity
HW576_06410	COG0697	spore germination
HW576_06430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HW576_06435	COG0720	synthase
HW576_06445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HW576_06450	COG0702	epimerase
HW576_06460	COG4873	Protein conserved in bacteria
HW576_06480	COG3773	Cell wall hydrolase
HW576_06520	COG0646	methionine synthase
HW576_06520	COG1410	methionine synthase
HW576_06525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HW576_06525	COG0646	methionine synthase
HW576_06530	COG3949	Membrane
HW576_06535	COG0307	riboflavin synthase, alpha
HW576_06545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HW576_06555	COG3711	transcriptional antiterminator
HW576_06560	COG1263	PTS System
HW576_06560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW576_06560	COG2190	(PTS) system
HW576_06575	COG1346	cytolysis
HW576_06585	COG0583	DNA-binding transcription factor activity
HW576_06595	COG0456	acetyltransferase
HW576_06600	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_06605	COG0778	Nitroreductase
HW576_06610	COG0436	Aminotransferase
HW576_06630	COG0784	Response regulator, receiver
HW576_06630	COG0835	chemotaxis
HW576_06640	COG1376	ErfK ybiS ycfS ynhG family protein
HW576_06645	COG0248	Ppx GppA phosphatase
HW576_06660	COG1408	metallophosphoesterase
HW576_06665	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_06670	COG2200	EAL domain
HW576_06685	COG4703	Protein of unknown function (DUF1797)
HW576_06690	COG0517	IMP dehydrogenase activity
HW576_06695	COG0583	DNA-binding transcription factor activity
HW576_06700	COG2171	N-acyltransferase activity
HW576_06705	COG1473	amidohydrolase
HW576_06715	COG0668	transmembrane transport
HW576_06720	COG0450	alkyl hydroperoxide reductase
HW576_06725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW576_06730	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HW576_06735	COG1132	(ABC) transporter
HW576_06740	COG1132	(ABC) transporter
HW576_06745	COG0569	domain protein
HW576_06750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW576_06760	COG0561	phosphatase activity
HW576_06785	COG0022	dehydrogenase e1 component
HW576_06790	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW576_06815	COG1982	Orn Lys Arg decarboxylase major
HW576_06820	COG4476	Belongs to the UPF0223 family
HW576_06825	COG4493	Belongs to the UPF0637 family
HW576_06835	COG0483	inositol monophosphate 1-phosphatase activity
HW576_06860	COG4896	Protein conserved in bacteria
HW576_06875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HW576_06880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HW576_06885	COG4838	Belongs to the UPF0358 family
HW576_06890	COG0772	Belongs to the SEDS family
HW576_06895	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HW576_06900	COG1612	heme a metabolic process
HW576_06905	COG0109	protoheme IX farnesyltransferase activity
HW576_06930	COG3336	cytochrome c oxidase
HW576_06940	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HW576_06945	COG2340	Cysteine-rich secretory protein family
HW576_06955	COG2738	Putative neutral zinc metallopeptidase
HW576_06960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_06965	COG1694	Mazg nucleotide pyrophosphohydrolase
HW576_06970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HW576_06975	COG1803	Methylglyoxal synthase
HW576_06980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HW576_06985	COG0438	transferase activity, transferring glycosyl groups
HW576_06990	COG0617	tRNA 3'-terminal CCA addition
HW576_06995	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HW576_06995	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HW576_07005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HW576_07010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HW576_07015	COG1199	ATP-dependent helicase activity
HW576_07015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW576_07035	COG0436	Aminotransferase
HW576_07040	COG0017	Asparaginyl-tRNA synthetase
HW576_07045	COG3935	DnaD domain protein
HW576_07050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HW576_07060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW576_07060	COG4499	WXG100 protein secretion system (Wss), protein YukC
HW576_07065	COG3331	DNA recombination
HW576_07110	COG5337	Spore coat protein CotH
HW576_07125	COG0626	cystathionine gamma-synthase activity
HW576_07130	COG0626	cystathionine gamma-synthase activity
HW576_07145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW576_07170	COG3706	GGDEF domain
HW576_07180	COG1205	dead DEAH box helicase
HW576_07180	COG1111	helicase
HW576_07185	COG3359	exonuclease
HW576_07195	COG4474	Belongs to the UPF0398 family
HW576_07200	COG3599	regulation of cell shape
HW576_07230	COG2197	response regulator
HW576_07235	COG0366	Alpha amylase catalytic
HW576_07240	COG0116	Belongs to the methyltransferase superfamily
HW576_07255	COG1175	transmembrane transport
HW576_07265	COG3842	ATPase activity
HW576_07275	COG1199	ATP-dependent helicase activity
HW576_07280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HW576_07285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW576_07290	COG2233	PERMEase
HW576_07295	COG0583	DNA-binding transcription factor activity
HW576_07300	COG1012	belongs to the aldehyde dehydrogenase family
HW576_07310	COG3424	synthase
HW576_07315	COG1755	Isoprenylcysteine carboxyl methyltransferase
HW576_07320	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HW576_07325	COG3541	Predicted nucleotidyltransferase
HW576_07350	COG0328	RNA-DNA hybrid ribonuclease activity
HW576_07355	COG0328	RNA-DNA hybrid ribonuclease activity
HW576_07380	COG2814	Major facilitator Superfamily
HW576_07390	COG2233	PERMEase
HW576_07395	COG2362	D-Aminopeptidase
HW576_07400	COG0601	transmembrane transport
HW576_07405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW576_07410	COG0444	Belongs to the ABC transporter superfamily
HW576_07415	COG4166	transmembrane transport
HW576_07420	COG1619	proteins homologs of microcin C7 resistance protein MccF
HW576_07425	COG0791	NLP P60 protein
HW576_07430	COG4608	Belongs to the ABC transporter superfamily
HW576_07450	COG5001	Diguanylate cyclase
HW576_07450	COG3300	MHYT domain
HW576_07480	COG2197	response regulator
HW576_07485	COG4585	Histidine kinase
HW576_07490	COG3239	Fatty acid desaturase
HW576_07495	COG2205	protein histidine kinase activity
HW576_07505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW576_07520	COG1388	LysM domain
HW576_07520	COG0791	NLP P60 protein
HW576_07525	COG1819	glycosyl
HW576_07530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW576_07545	COG2814	Major facilitator Superfamily
HW576_07555	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_07560	COG3964	amidohydrolase
HW576_07580	COG2188	Transcriptional regulator
HW576_07590	COG0434	BtpA family
HW576_07595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW576_07605	COG1785	Belongs to the alkaline phosphatase family
HW576_07610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HW576_07615	COG1404	Belongs to the peptidase S8 family
HW576_07625	COG1846	Transcriptional regulator
HW576_07630	COG1566	PFAM secretion protein HlyD family protein
HW576_07635	COG2814	Major facilitator Superfamily
HW576_07640	COG1846	Transcriptional regulator
HW576_07660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW576_07665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW576_07670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW576_07675	COG1120	ATPase activity
HW576_07680	COG0492	ferredoxin-NADP+ reductase activity
HW576_07690	COG2814	Major facilitator Superfamily
HW576_07710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW576_07715	COG1733	regulation of RNA biosynthetic process
HW576_07720	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HW576_07730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW576_07740	COG3448	diguanylate cyclase activity
HW576_07740	COG4175	Glycine betaine
HW576_07745	COG4176	ABC-type proline glycine betaine transport system permease component
HW576_07760	COG0784	Response regulator, receiver
HW576_07760	COG2205	protein histidine kinase activity
HW576_07765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HW576_07770	COG2208	phosphoserine phosphatase activity
HW576_07780	COG0531	amino acid
HW576_07790	COG1011	Hydrolase
HW576_07795	COG0405	Gamma-glutamyltransferase
HW576_07800	COG1621	beta-fructofuranosidase activity
HW576_07805	COG1621	beta-fructofuranosidase activity
HW576_07810	COG2193	ferroxidase activity
HW576_07815	COG0477	Major facilitator Superfamily
HW576_07820	COG0156	8-amino-7-oxononanoate synthase activity
HW576_07825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW576_07835	COG2814	Major facilitator Superfamily
HW576_07850	COG1012	belongs to the aldehyde dehydrogenase family
HW576_07855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW576_07865	COG1280	lysine exporter protein (LysE YggA)
HW576_07870	COG1113	amino acid transport
HW576_07885	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW576_07915	COG1113	amino acid transport
HW576_07935	COG1609	Transcriptional regulator
HW576_07950	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HW576_07955	COG1621	beta-fructofuranosidase activity
HW576_07960	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HW576_07960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HW576_07965	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW576_07970	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW576_07975	COG3715	PTS system
HW576_07980	COG3716	PTS system mannose fructose sorbose family IID component
HW576_07985	COG1621	beta-fructofuranosidase activity
HW576_07990	COG0765	amino acid transport
HW576_07995	COG0765	amino acid transport
HW576_08000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW576_08005	COG1464	Belongs to the NlpA lipoprotein family
HW576_08010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW576_08015	COG2011	ABC-type metal ion transport system permease component
HW576_08035	COG1464	Belongs to the NlpA lipoprotein family
HW576_08040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW576_08045	COG2011	ABC-type metal ion transport system permease component
HW576_08050	COG1464	Belongs to the NlpA lipoprotein family
HW576_08055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_08060	COG0024	Methionine aminopeptidase
HW576_08080	COG0596	Alpha beta hydrolase
HW576_08085	COG0697	spore germination
HW576_08100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW576_08105	COG0531	amino acid
HW576_08120	COG2723	6-phospho-beta-galactosidase activity
HW576_08125	COG2188	Transcriptional regulator
HW576_08135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW576_08145	COG0656	L-ascorbic acid biosynthetic process
HW576_08150	COG2986	histidine ammonia-lyase
HW576_08160	COG1228	amidohydrolase
HW576_08165	COG0010	Belongs to the arginase family
HW576_08170	COG1846	Transcriptional regulator
HW576_08185	COG0473	3-isopropylmalate dehydrogenase activity
HW576_08190	COG1288	antiporter activity
HW576_08195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW576_08225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_08245	COG2364	Membrane
HW576_08250	COG1846	Transcriptional regulator
HW576_08255	COG0456	acetyltransferase
HW576_08285	COG3848	Pyruvate phosphate dikinase
HW576_08285	COG0574	Belongs to the PEP-utilizing enzyme family
HW576_08290	COG1309	transcriptional regulator
HW576_08295	COG2814	Major facilitator Superfamily
HW576_08300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HW576_08305	COG3958	Transketolase
HW576_08310	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_08315	COG2186	Transcriptional regulator
HW576_08325	COG0205	6-phosphofructokinase activity
HW576_08335	COG0698	ribose 5-phosphate isomerase
HW576_08360	COG0791	NLP P60 protein
HW576_08360	COG1388	LysM domain
HW576_08365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HW576_08380	COG2318	DinB family
HW576_08405	COG0583	DNA-binding transcription factor activity
HW576_08410	COG0596	Alpha beta hydrolase
HW576_08430	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_08445	COG5002	protein histidine kinase activity
HW576_08445	COG3850	Histidine kinase
HW576_08450	COG0745	RESPONSE REGULATOR receiver
HW576_08455	COG0586	Pfam SNARE associated Golgi protein
HW576_08470	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW576_08480	COG0697	spore germination
HW576_08515	COG0387	Pfam Sodium calcium exchanger
HW576_08520	COG0318	PFAM AMP-dependent synthetase and ligase
HW576_08535	COG1309	transcriptional regulator
HW576_08540	COG0861	Integral membrane protein TerC family
HW576_08550	COG5577	PFAM Coat F domain
HW576_08560	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_08570	COG1522	sequence-specific DNA binding
HW576_08575	COG3813	Protein conserved in bacteria
HW576_08595	COG2076	Multidrug Resistance protein
HW576_08610	COG1278	Cold shock
HW576_08620	COG0513	Belongs to the DEAD box helicase family
HW576_08625	COG1278	Cold shock
HW576_08640	COG0028	Belongs to the TPP enzyme family
HW576_08675	COG2172	sigma factor antagonist activity
HW576_08680	COG1388	LysM domain
HW576_08680	COG3858	chitin binding
HW576_08685	COG1376	ErfK ybiS ycfS ynhG family protein
HW576_08715	COG2226	methyltransferase
HW576_08725	COG1733	regulation of RNA biosynthetic process
HW576_08730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW576_08745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_08750	COG3420	alginic acid biosynthetic process
HW576_08770	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW576_08775	COG0640	Transcriptional regulator
HW576_08780	COG0640	Transcriptional regulator
HW576_08785	COG0346	lactoylglutathione lyase activity
HW576_08790	COG0475	glutathione-regulated potassium exporter activity
HW576_08790	COG0589	response to stress
HW576_08800	COG3011	Protein conserved in bacteria
HW576_08830	COG0583	DNA-binding transcription factor activity
HW576_08835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HW576_08845	COG0753	catalase activity
HW576_08860	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_08865	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_08895	COG5577	PFAM Coat F domain
HW576_08905	COG1063	alcohol dehydrogenase
HW576_08910	COG5577	PFAM Coat F domain
HW576_08925	COG2205	protein histidine kinase activity
HW576_08925	COG0784	Response regulator, receiver
HW576_08945	COG0673	inositol 2-dehydrogenase activity
HW576_08950	COG0673	inositol 2-dehydrogenase activity
HW576_08955	COG1082	Xylose isomerase domain protein TIM barrel
HW576_08960	COG2814	Major facilitator Superfamily
HW576_08970	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_08985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_09000	COG0384	phenazine biosynthesis protein PhzF
HW576_09005	COG1694	Mazg nucleotide pyrophosphohydrolase
HW576_09015	COG2226	methyltransferase
HW576_09025	COG0789	Transcriptional regulator
HW576_09030	COG1278	Cold shock
HW576_09080	COG1113	amino acid transport
HW576_09090	COG2207	Transcriptional regulator
HW576_09100	COG2376	Dihydroxyacetone kinase
HW576_09120	COG0745	RESPONSE REGULATOR receiver
HW576_09125	COG0745	RESPONSE REGULATOR receiver
HW576_09130	COG5002	protein histidine kinase activity
HW576_09135	COG0671	phosphoesterase, PA-phosphatase related
HW576_09160	COG0583	DNA-binding transcription factor activity
HW576_09170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_09175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW576_09180	COG1116	anion transmembrane transporter activity
HW576_09190	COG1024	Enoyl-CoA hydratase
HW576_09195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW576_09255	COG2323	membrane
HW576_09260	COG2323	membrane
HW576_09275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW576_09350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_09355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW576_09370	COG0583	DNA-binding transcription factor activity
HW576_09375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW576_09380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW576_09385	COG1587	Uroporphyrinogen-III synthase
HW576_09390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_09395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW576_09410	COG1982	Orn Lys Arg decarboxylase major
HW576_09425	COG1073	alpha beta
HW576_09440	COG3545	Serine hydrolase
HW576_09450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW576_09460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW576_09475	COG1278	Cold shock
HW576_09485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_09490	COG0697	spore germination
HW576_09505	COG0697	spore germination
HW576_09510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW576_09530	COG1335	isochorismatase
HW576_09535	COG0138	bifunctional purine biosynthesis protein purh
HW576_09540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_09545	COG1114	Component of the transport system for branched-chain amino acids
HW576_09555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW576_09575	COG1017	nitric oxide dioxygenase activity
HW576_09575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW576_09585	COG0574	Belongs to the PEP-utilizing enzyme family
HW576_09585	COG3848	Pyruvate phosphate dikinase
HW576_09590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HW576_09600	COG0601	transmembrane transport
HW576_09610	COG0444	Belongs to the ABC transporter superfamily
HW576_09615	COG4608	Belongs to the ABC transporter superfamily
HW576_09620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW576_09625	COG0477	Major facilitator Superfamily
HW576_09645	COG1012	belongs to the aldehyde dehydrogenase family
HW576_09680	COG0517	IMP dehydrogenase activity
HW576_09700	COG1309	transcriptional regulator
HW576_09715	COG1070	Carbohydrate kinase
HW576_09720	COG0477	Major facilitator Superfamily
HW576_09720	COG2814	Major facilitator Superfamily
HW576_09735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW576_09740	COG1845	cytochrome c oxidase, subunit III
HW576_09750	COG0589	response to stress
HW576_09755	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_09760	COG1612	heme a metabolic process
HW576_09765	COG2072	flavoprotein involved in K transport
HW576_09775	COG2252	PERMEase
HW576_09785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW576_09790	COG0022	dehydrogenase e1 component
HW576_09795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW576_09800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW576_09805	COG3284	Transcriptional regulator
HW576_09810	COG1063	alcohol dehydrogenase
HW576_09820	COG1846	Transcriptional regulator
HW576_09830	COG2721	sulfolactate sulfo-lyase activity
HW576_09840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HW576_09845	COG1012	belongs to the aldehyde dehydrogenase family
HW576_09850	COG2271	Major facilitator Superfamily
HW576_09855	COG4948	Mandelate Racemase Muconate Lactonizing
HW576_09860	COG2186	Transcriptional regulator
HW576_09880	COG0628	permease
HW576_09885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW576_09895	COG2211	Major facilitator Superfamily
HW576_09915	COG0589	response to stress
HW576_09920	COG5002	protein histidine kinase activity
HW576_09930	COG1937	Protein conserved in bacteria
HW576_09935	COG2608	mercury ion transmembrane transporter activity
HW576_09940	COG2217	Heavy metal translocating P-type atpase
HW576_09950	COG1388	LysM domain
HW576_09955	COG2271	Major facilitator Superfamily
HW576_09985	COG0640	Transcriptional regulator
HW576_09990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW576_10005	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HW576_10010	COG2323	membrane
HW576_10025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW576_10030	COG1802	Transcriptional regulator
HW576_10035	COG0473	3-isopropylmalate dehydrogenase activity
HW576_10040	COG2814	Major facilitator Superfamily
HW576_10045	COG1733	regulation of RNA biosynthetic process
HW576_10050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW576_10050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW576_10055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW576_10055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW576_10085	COG5566	PFAM Mor transcription activator
HW576_10100	COG0561	phosphatase activity
HW576_10105	COG1876	peptidase activity
HW576_10155	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HW576_10170	COG0386	Belongs to the glutathione peroxidase family
HW576_10175	COG1418	mRNA catabolic process
HW576_10180	COG0488	(ABC) transporter
HW576_10185	COG1413	lyase activity
HW576_10190	COG0726	polysaccharide deacetylase
HW576_10200	COG2521	methyltransferase
HW576_10200	COG2136	Putative SAM-dependent methyltransferase
HW576_10210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW576_10215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW576_10225	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HW576_10230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW576_10235	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HW576_10240	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HW576_10245	COG0406	alpha-ribazole phosphatase activity
HW576_10255	COG2096	Adenosyltransferase
HW576_10260	COG2962	Rard protein
HW576_10275	COG0523	cobalamin synthesis protein
HW576_10280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW576_10285	COG0322	excinuclease ABC activity
HW576_10295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW576_10300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HW576_10305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HW576_10315	COG3011	Protein conserved in bacteria
HW576_10320	COG1595	DNA-templated transcription, initiation
HW576_10340	COG2002	toxin-antitoxin pair type II binding
HW576_10345	COG0534	Mate efflux family protein
HW576_10350	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_10375	COG1368	sulfuric ester hydrolase activity
HW576_10385	COG3853	Toxic anion resistance protein (TelA)
HW576_10415	COG2234	aminopeptidase activity
HW576_10420	COG5002	protein histidine kinase activity
HW576_10430	COG1823	symporter activity
HW576_10435	COG1523	belongs to the glycosyl hydrolase 13 family
HW576_10440	COG1012	belongs to the aldehyde dehydrogenase family
HW576_10445	COG2124	cytochrome p450
HW576_10450	COG2112	serine threonine protein kinase
HW576_10465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HW576_10470	COG1360	Flagellar Motor Protein
HW576_10485	COG3361	conserved protein (COG2071)
HW576_10490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW576_10495	COG1757	Na H antiporter
HW576_10505	COG0833	amino acid
HW576_10510	COG3594	Acyltransferase
HW576_10515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW576_10525	COG0745	RESPONSE REGULATOR receiver
HW576_10530	COG5002	protein histidine kinase activity
HW576_10535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW576_10540	COG3104	oligopeptide transport
HW576_10550	COG0281	malic enzyme
HW576_10555	COG3493	citrate carrier protein
HW576_10560	COG0561	phosphatase activity
HW576_10565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_10575	COG0456	acetyltransferase
HW576_10580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HW576_10585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW576_10590	COG0765	amino acid transport
HW576_10595	COG0765	amino acid transport
HW576_10600	COG1126	abc transporter atp-binding protein
HW576_10605	COG0196	riboflavin kinase activity
HW576_10610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_10620	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW576_10660	COG1611	Belongs to the LOG family
HW576_10665	COG0281	malic enzyme
HW576_10670	COG3402	PFAM membrane-flanked domain
HW576_10675	COG3428	Bacterial PH domain
HW576_10690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW576_10695	COG0109	protoheme IX farnesyltransferase activity
HW576_10700	COG4195	phage-related replication protein
HW576_10715	COG0789	Transcriptional regulator
HW576_10750	COG0583	DNA-binding transcription factor activity
HW576_10755	COG0067	glutamate synthase
HW576_10755	COG0069	glutamate synthase activity
HW576_10755	COG0070	glutamate synthase
HW576_10760	COG0493	'glutamate synthase
HW576_10780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HW576_10795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW576_10805	COG1846	Transcriptional regulator
HW576_10810	COG1380	Effector of murein hydrolase LrgA
HW576_10815	COG1346	cytolysis
HW576_10820	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_10835	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HW576_10840	COG0463	Glycosyl transferase, family 2
HW576_10850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW576_10855	COG0745	RESPONSE REGULATOR receiver
HW576_10865	COG5583	Uncharacterized small protein (DUF2292)
HW576_10875	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HW576_10885	COG4208	sulfate ABC transporter
HW576_10900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_10915	COG1349	DNA-binding transcription factor activity
HW576_10920	COG1105	Belongs to the carbohydrate kinase PfkB family
HW576_10925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW576_10925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW576_10925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW576_10930	COG0527	aspartate kinase activity
HW576_10940	COG2032	superoxide dismutase activity
HW576_10945	COG1233	COG1233 Phytoene dehydrogenase and related
HW576_10955	COG0300	oxidoreductase activity
HW576_10960	COG0640	Transcriptional regulator
HW576_10965	COG1012	belongs to the aldehyde dehydrogenase family
HW576_10970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HW576_10985	COG0733	neurotransmitter:sodium symporter activity
HW576_10995	COG3773	Cell wall hydrolase
HW576_11015	COG0673	inositol 2-dehydrogenase activity
HW576_11020	COG1082	Xylose isomerase domain protein TIM barrel
HW576_11025	COG2094	Belongs to the DNA glycosylase MPG family
HW576_11030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW576_11040	COG0454	-acetyltransferase
HW576_11050	COG2814	Major facilitator Superfamily
HW576_11065	COG3871	stress protein (general stress protein 26)
HW576_11090	COG1595	DNA-templated transcription, initiation
HW576_11095	COG4873	Protein conserved in bacteria
HW576_11100	COG0714	Associated with various cellular activities
HW576_11105	COG4548	von Willebrand factor, type A
HW576_11110	COG0697	spore germination
HW576_11120	COG2207	Transcriptional regulator
HW576_11125	COG1994	Peptidase M50
HW576_11130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_11135	COG1119	ATPase activity
HW576_11150	COG1657	PFAM Prenyltransferase squalene oxidase
HW576_11160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HW576_11160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HW576_11170	COG0384	phenazine biosynthesis protein PhzF
HW576_11185	COG1378	Sugar-specific transcriptional regulator TrmB
HW576_11190	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HW576_11195	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_11215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_11220	COG1279	arginine transmembrane transporter activity
HW576_11250	COG3944	biosynthesis protein
HW576_11255	COG0489	protein tyrosine kinase activity
HW576_11265	COG1086	Polysaccharide biosynthesis protein
HW576_11270	COG0438	transferase activity, transferring glycosyl groups
HW576_11275	COG0438	transferase activity, transferring glycosyl groups
HW576_11280	COG1215	transferase activity, transferring glycosyl groups
HW576_11290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW576_11300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HW576_11305	COG0110	maltose O-acetyltransferase activity
HW576_11310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HW576_11315	COG1396	sequence-specific DNA binding
HW576_11330	COG1216	Glycosyl transferase, family 2
HW576_11330	COG1442	glycosyl transferase family 8
HW576_11355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW576_11365	COG5297	Belongs to the glycosyl hydrolase family 6
HW576_11365	COG4733	cellulase activity
HW576_11400	COG1132	(ABC) transporter
HW576_11435	COG1408	metallophosphoesterase
HW576_11440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW576_11450	COG0494	nUDIX hydrolase
HW576_11455	COG1335	isochorismatase
HW576_11460	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HW576_11465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW576_11470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HW576_11475	COG1098	S1 RNA binding domain
HW576_11480	COG1404	Belongs to the peptidase S8 family
HW576_11485	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_11490	COG1254	Belongs to the acylphosphatase family
HW576_11495	COG2223	nitrite transmembrane transporter activity
HW576_11500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_11510	COG2207	Transcriptional regulator
HW576_11510	COG0662	Cupin 2, conserved barrel domain protein
HW576_11515	COG0697	spore germination
HW576_11520	COG0488	(ABC) transporter
HW576_11525	COG0697	spore germination
HW576_11530	COG0531	amino acid
HW576_11545	COG1131	(ABC) transporter
HW576_11550	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HW576_11555	COG1757	Na H antiporter
HW576_11560	COG1609	Transcriptional regulator
HW576_11570	COG1533	DNA photolyase activity
HW576_11590	COG0551	DNA topoisomerase type I activity
HW576_11590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW576_11600	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW576_11625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW576_11645	COG1757	Na H antiporter
HW576_11660	COG0697	spore germination
HW576_11670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_11680	COG2720	vancomycin resistance protein
HW576_11720	COG0514	ATP-dependent DNA helicase (RecQ)
HW576_11735	COG1012	belongs to the aldehyde dehydrogenase family
HW576_11750	COG1575	Belongs to the MenA family. Type 1 subfamily
HW576_11755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HW576_11770	COG2814	Major facilitator Superfamily
HW576_11775	COG0583	DNA-binding transcription factor activity
HW576_11780	COG1725	Transcriptional regulator
HW576_11785	COG1131	(ABC) transporter
HW576_11795	COG1595	DNA-templated transcription, initiation
HW576_11810	COG1764	response to oxidative stress
HW576_11815	COG1846	Transcriptional regulator
HW576_11830	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HW576_11840	COG3584	3D domain protein
HW576_11840	COG1388	LysM domain
HW576_11860	COG5002	protein histidine kinase activity
HW576_11865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW576_11870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HW576_11875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HW576_11890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HW576_11905	COG2409	Drug exporters of the RND superfamily
HW576_11910	COG1834	amidinotransferase
HW576_11920	COG1295	ribonuclease BN
HW576_12005	COG0110	maltose O-acetyltransferase activity
HW576_12010	COG0346	lactoylglutathione lyase activity
HW576_12020	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_12030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW576_12040	COG2176	DNA-directed DNA polymerase activity
HW576_12055	COG0114	fumarate hydratase activity
HW576_12065	COG3757	hydrolase, family 25
HW576_12065	COG3409	Peptidoglycan-binding domain 1 protein
HW576_12075	COG5002	protein histidine kinase activity
HW576_12115	COG0778	Nitroreductase
HW576_12125	COG0300	oxidoreductase activity
HW576_12130	COG3290	protein histidine kinase activity
HW576_12135	COG4565	transcriptional regulatory protein
HW576_12140	COG2851	Citrate transporter
HW576_12150	COG2610	gluconate transmembrane transporter activity
HW576_12155	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_12160	COG2195	Cleaves the N-terminal amino acid of tripeptides
HW576_12185	COG4122	O-methyltransferase activity
HW576_12190	COG0583	DNA-binding transcription factor activity
HW576_12200	COG1301	dicarboxylic acid transport
HW576_12205	COG0019	diaminopimelate decarboxylase activity
HW576_12215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW576_12225	COG4191	Histidine kinase
HW576_12235	COG1960	acyl-CoA dehydrogenase activity
HW576_12240	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_12245	COG0318	PFAM AMP-dependent synthetase and ligase
HW576_12255	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW576_12260	COG1024	Enoyl-CoA hydratase
HW576_12275	COG2045	Belongs to the ComB family
HW576_12280	COG1960	acyl-CoA dehydrogenase activity
HW576_12285	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_12290	COG1024	Enoyl-CoA hydratase
HW576_12305	COG1141	Ferredoxin
HW576_12315	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW576_12325	COG0183	Belongs to the thiolase family
HW576_12330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW576_12355	COG1509	lysine 2,3-aminomutase activity
HW576_12365	COG0833	amino acid
HW576_12370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW576_12385	COG1979	alcohol dehydrogenase
HW576_12390	COG0738	Major facilitator superfamily
HW576_12395	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW576_12415	COG3977	Valine--pyruvate aminotransferase
HW576_12420	COG3773	Cell wall hydrolase
HW576_12430	COG3119	arylsulfatase activity
HW576_12435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW576_12445	COG0531	amino acid
HW576_12450	COG2814	Major facilitator Superfamily
HW576_12455	COG1846	Transcriptional regulator
HW576_12460	COG2409	Drug exporters of the RND superfamily
HW576_12460	COG1033	growth of symbiont in host cell
HW576_12475	COG2222	sugar isomerase
HW576_12480	COG1653	transport
HW576_12485	COG1175	transmembrane transport
HW576_12490	COG0395	ABC-type sugar transport system, permease component
HW576_12495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW576_12500	COG2188	Transcriptional regulator
HW576_12505	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_12505	COG2202	Pas domain
HW576_12510	COG3832	glyoxalase III activity
HW576_12515	COG0640	Transcriptional regulator
HW576_12525	COG2267	carboxylic ester hydrolase activity
HW576_12535	COG3386	PFAM SMP-30 Gluconolaconase
HW576_12545	COG2368	4-hydroxyphenylacetate
HW576_12550	COG3739	integral membrane protein
HW576_12560	COG0326	Molecular chaperone. Has ATPase activity
HW576_12565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW576_12585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW576_12590	COG3409	Peptidoglycan-binding domain 1 protein
HW576_12590	COG3757	hydrolase, family 25
HW576_12600	COG0697	spore germination
HW576_12605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_12620	COG4572	Cation transport regulator
HW576_12625	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HW576_12635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW576_12645	COG3011	Protein conserved in bacteria
HW576_12650	COG1136	(ABC) transporter
HW576_12690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW576_12705	COG0494	nUDIX hydrolase
HW576_12710	COG0702	epimerase
HW576_12715	COG0318	PFAM AMP-dependent synthetase and ligase
HW576_12720	COG1846	Transcriptional regulator
HW576_12725	COG2720	vancomycin resistance protein
HW576_12730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW576_12755	COG0076	glutamate decarboxylase activity
HW576_12780	COG2116	formate transmembrane transporter activity
HW576_12785	COG5609	conserved protein (DUF2294)
HW576_12800	COG2271	Major facilitator Superfamily
HW576_12805	COG0277	FAD linked oxidase domain protein
HW576_12815	COG0840	transmembrane signaling receptor activity
HW576_12825	COG0622	Phosphoesterase
HW576_12835	COG1408	metallophosphoesterase
HW576_12840	COG3663	DNA glycosylase
HW576_12845	COG0791	NLP P60 protein
HW576_12845	COG3883	PFAM NLP P60 protein
HW576_12850	COG1587	Uroporphyrinogen-III synthase
HW576_12855	COG1414	Transcriptional regulator
HW576_12860	COG0439	Biotin carboxylase
HW576_12865	COG0511	ligase activity, forming carbon-carbon bonds
HW576_12870	COG1984	allophanate hydrolase subunit 2
HW576_12875	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HW576_12880	COG4336	lyase activity
HW576_12885	COG1914	H( )-stimulated, divalent metal cation uptake system
HW576_12890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HW576_12905	COG0318	PFAM AMP-dependent synthetase and ligase
HW576_12910	COG1268	BioY protein
HW576_12915	COG0183	Belongs to the thiolase family
HW576_12935	COG0431	NADPH-dependent FMN reductase
HW576_12940	COG2197	response regulator
HW576_12945	COG4585	Histidine kinase
HW576_12945	COG2203	Gaf domain
HW576_12965	COG0697	spore germination
HW576_12975	COG2153	protein acetylation
HW576_12980	COG0129	dihydroxy-acid dehydratase activity
HW576_12985	COG2267	carboxylic ester hydrolase activity
HW576_12990	COG1227	inorganic diphosphatase activity
HW576_13010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW576_13020	COG0204	Acyl-transferase
HW576_13025	COG2233	PERMEase
HW576_13030	COG3648	Uricase
HW576_13030	COG3195	allantoin biosynthetic process
HW576_13040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_13055	COG1914	H( )-stimulated, divalent metal cation uptake system
HW576_13070	COG1011	Hydrolase
HW576_13075	COG1846	Transcriptional regulator
HW576_13085	COG4974	Belongs to the 'phage' integrase family
HW576_13105	COG0531	amino acid
HW576_13110	COG4302	ethanolamine ammonia-lyase activity
HW576_13115	COG4303	Ethanolamine ammonia lyase large subunit
HW576_13120	COG4819	ethanolamine utilization protein
HW576_13130	COG0833	amino acid
HW576_13140	COG1247	-acetyltransferase
HW576_13145	COG1335	isochorismatase
HW576_13155	COG3403	YqcI/YcgG family
HW576_13160	COG1280	lysine exporter protein (LysE YggA)
HW576_13165	COG2267	carboxylic ester hydrolase activity
HW576_13170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW576_13175	COG0187	DNA topoisomerase II activity
HW576_13180	COG1832	CoA-binding protein
HW576_13185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HW576_13190	COG4841	protein insertion into membrane
HW576_13195	COG0824	Thioesterase
HW576_13225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW576_13230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HW576_13250	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HW576_13285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW576_13290	COG2068	MobA-Related Protein
HW576_13295	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HW576_13350	COG1183	phosphatidylcholine synthase activity
HW576_13365	COG2814	Major facilitator Superfamily
HW576_13370	COG1683	Conserved Protein
HW576_13375	COG1302	Protein conserved in bacteria
HW576_13390	COG1295	ribonuclease BN
HW576_13400	COG1115	amino acid carrier protein
HW576_13405	COG2814	Major facilitator Superfamily
HW576_13415	COG2814	Major facilitator Superfamily
HW576_13420	COG0789	Transcriptional regulator
HW576_13430	COG0288	reversible hydration of carbon dioxide
HW576_13435	COG0659	secondary active sulfate transmembrane transporter activity
HW576_13440	COG0745	RESPONSE REGULATOR receiver
HW576_13445	COG5002	protein histidine kinase activity
HW576_13455	COG0477	Major facilitator Superfamily
HW576_13460	COG4282	regulation of fungal-type cell wall biogenesis
HW576_13465	COG0531	amino acid
HW576_13475	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW576_13480	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HW576_13555	COG1363	Peptidase, m42
HW576_13565	COG1114	Component of the transport system for branched-chain amino acids
HW576_13585	COG0004	ammonium transporteR
HW576_13600	COG1252	NADH dehydrogenase
HW576_13605	COG0679	Auxin Efflux Carrier
HW576_13610	COG0281	malic enzyme
HW576_13615	COG1473	amidohydrolase
HW576_13620	COG2271	Major facilitator Superfamily
HW576_13640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HW576_13645	COG0163	prenyltransferase activity
HW576_13650	COG0583	DNA-binding transcription factor activity
HW576_13655	COG0679	Auxin Efflux Carrier
HW576_13675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_13680	COG0247	lactate metabolic process
HW576_13685	COG0277	FAD linked oxidase domain protein
HW576_13690	COG3835	regulator
HW576_13695	COG0693	protein deglycase activity
HW576_13705	COG2610	gluconate transmembrane transporter activity
HW576_13725	COG1131	(ABC) transporter
HW576_13735	COG2197	response regulator
HW576_13770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_13780	COG0586	Pfam SNARE associated Golgi protein
HW576_13785	COG1515	deoxyribonuclease V activity
HW576_13790	COG0584	glycerophosphoryl diester phosphodiesterase
HW576_13795	COG3153	acetyltransferase
HW576_13795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW576_13805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW576_13810	COG0531	amino acid
HW576_13930	COG0534	Mate efflux family protein
HW576_13935	COG1566	PFAM secretion protein HlyD family protein
HW576_13945	COG1846	Transcriptional regulator
HW576_13950	COG0708	Exodeoxyribonuclease III
HW576_13970	COG0673	inositol 2-dehydrogenase activity
HW576_13975	COG1349	DNA-binding transcription factor activity
HW576_13980	COG3853	Toxic anion resistance protein (TelA)
HW576_13990	COG2310	stress, protein
HW576_13995	COG2310	stress, protein
HW576_14000	COG2310	stress, protein
HW576_14005	COG1525	nuclease
HW576_14005	COG0737	Belongs to the 5'-nucleotidase family
HW576_14005	COG4085	toxin activity
HW576_14010	COG0737	Belongs to the 5'-nucleotidase family
HW576_14020	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HW576_14025	COG1131	(ABC) transporter
HW576_14035	COG2084	Dehydrogenase
HW576_14040	COG1278	Cold shock
HW576_14045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_14050	COG0028	Belongs to the TPP enzyme family
HW576_14055	COG1278	Cold shock
HW576_14085	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_14095	COG0427	acetyl-CoA hydrolase
HW576_14100	COG3279	Response regulator of the LytR AlgR family
HW576_14105	COG2323	membrane
HW576_14110	COG2814	Major facilitator Superfamily
HW576_14115	COG3584	3D domain protein
HW576_14115	COG1388	LysM domain
HW576_14120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HW576_14145	COG3340	Belongs to the peptidase S51 family
HW576_14175	COG3586	endonuclease activity
HW576_14245	COG2318	DinB family
HW576_14255	COG0579	oxidoreductase
HW576_14285	COG1486	melibiose metabolic process
HW576_14290	COG0395	ABC-type sugar transport system, permease component
HW576_14295	COG1175	transmembrane transport
HW576_14300	COG1653	transport
HW576_14305	COG1609	Transcriptional regulator
HW576_14325	COG1929	Belongs to the glycerate kinase type-1 family
HW576_14330	COG2610	gluconate transmembrane transporter activity
HW576_14335	COG3835	regulator
HW576_14340	COG1454	alcohol dehydrogenase
HW576_14345	COG3152	Membrane
HW576_14370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW576_14375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_14385	COG3152	Membrane
HW576_14405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HW576_14415	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HW576_14430	COG2390	Transcriptional regulator
HW576_14460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HW576_14465	COG0501	Belongs to the peptidase M48B family
HW576_14470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW576_14475	COG1742	UPF0060 membrane protein
HW576_14480	COG2182	Extracellular solute-binding protein
HW576_14500	COG2031	fatty acid transporter
HW576_14525	COG2391	methyltransferase activity
HW576_14540	COG1979	alcohol dehydrogenase
HW576_14545	COG0583	DNA-binding transcription factor activity
HW576_14590	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_14595	COG1063	alcohol dehydrogenase
HW576_14620	COG0025	NhaP-type Na H and K H
HW576_14625	COG1253	flavin adenine dinucleotide binding
HW576_14650	COG4608	Belongs to the ABC transporter superfamily
HW576_14660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW576_14665	COG0601	transmembrane transport
HW576_14670	COG0747	negative chemotaxis
HW576_14680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_14700	COG1525	nuclease
HW576_14710	COG0579	oxidoreductase
HW576_14715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HW576_14720	COG0561	phosphatase activity
HW576_14735	COG0668	transmembrane transport
HW576_14765	COG2309	aminopeptidase activity
HW576_14770	COG1414	Transcriptional regulator
HW576_14775	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW576_14780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HW576_14785	COG0277	FAD linked oxidase domain protein
HW576_14790	COG0247	lactate metabolic process
HW576_14795	COG0277	FAD linked oxidase domain protein
HW576_14800	COG1620	l-lactate permease
HW576_14825	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HW576_14830	COG1131	(ABC) transporter
HW576_14850	COG1595	DNA-templated transcription, initiation
HW576_14870	COG4682	membrane
HW576_14885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_14890	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_14895	COG0598	Magnesium transport protein CorA
HW576_14900	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW576_14910	COG2323	membrane
HW576_14915	COG1876	peptidase activity
HW576_14930	COG5002	protein histidine kinase activity
HW576_14935	COG0745	RESPONSE REGULATOR receiver
HW576_14955	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW576_14960	COG0567	Dehydrogenase, E1 component
HW576_14970	COG2814	Major facilitator Superfamily
HW576_14975	COG1764	response to oxidative stress
HW576_14985	COG2311	Membrane
HW576_15045	COG0347	Belongs to the P(II) protein family
HW576_15050	COG0004	ammonium transporteR
HW576_15055	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HW576_15070	COG0596	Alpha beta hydrolase
HW576_15085	COG0456	acetyltransferase
HW576_15085	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HW576_15090	COG1960	acyl-CoA dehydrogenase activity
HW576_15130	COG4604	ABC transporter, ATP-binding protein
HW576_15135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW576_15140	COG1492	cobalamin metabolic process
HW576_15150	COG0531	amino acid
HW576_15160	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_15165	COG2404	hydrolase activity, acting on ester bonds
HW576_15170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HW576_15180	COG1609	Transcriptional regulator
HW576_15190	COG2271	Major facilitator Superfamily
HW576_15195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW576_15210	COG1233	COG1233 Phytoene dehydrogenase and related
HW576_15215	COG0463	Glycosyl transferase, family 2
HW576_15270	COG0831	urea catabolic process
HW576_15275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW576_15280	COG0791	NLP P60 protein
HW576_15280	COG1388	LysM domain
HW576_15285	COG1388	LysM domain
HW576_15285	COG3584	3D domain protein
HW576_15290	COG0778	Nitroreductase
HW576_15295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW576_15300	COG0586	Pfam SNARE associated Golgi protein
HW576_15310	COG0400	carboxylic ester hydrolase activity
HW576_15315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW576_15320	COG2244	polysaccharide biosynthetic process
HW576_15325	COG0697	spore germination
HW576_15330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_15350	COG1132	(ABC) transporter
HW576_15375	COG4195	phage-related replication protein
HW576_15390	COG0783	Belongs to the Dps family
HW576_15400	COG5577	PFAM Coat F domain
HW576_15405	COG1253	flavin adenine dinucleotide binding
HW576_15420	COG0517	IMP dehydrogenase activity
HW576_15420	COG0516	GMP reductase activity
HW576_15430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW576_15430	COG0723	plastoquinol--plastocyanin reductase activity
HW576_15445	COG0287	Prephenate dehydrogenase
HW576_15455	COG1605	Chorismate mutase
HW576_15455	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HW576_15465	COG2059	Chromate
HW576_15470	COG2059	Chromate
HW576_15480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HW576_15485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW576_15490	COG2508	Transcriptional regulator
HW576_15495	COG0011	TIGRFAM Protein of
HW576_15500	COG1388	LysM domain
HW576_15500	COG0791	NLP P60 protein
HW576_15505	COG0753	catalase activity
HW576_15515	COG0733	neurotransmitter:sodium symporter activity
HW576_15560	COG0730	response to heat
HW576_15565	COG1902	pentaerythritol trinitrate reductase activity
HW576_15580	COG2205	protein histidine kinase activity
HW576_15590	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HW576_15620	COG0640	Transcriptional regulator
HW576_15630	COG0778	Nitroreductase
HW576_15645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HW576_15650	COG4991	sh3 domain protein
HW576_15650	COG3103	Sh3 type 3 domain protein
HW576_15650	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW576_15655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW576_15660	COG2002	toxin-antitoxin pair type II binding
HW576_15665	COG2318	DinB family
HW576_15670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW576_15680	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HW576_15685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_15700	COG2211	Major facilitator Superfamily
HW576_15705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_15710	COG1597	lipid kinase activity
HW576_15720	COG0372	Belongs to the citrate synthase family
HW576_15725	COG0583	DNA-binding transcription factor activity
HW576_15730	COG0697	spore germination
HW576_15735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_15755	COG2202	Pas domain
HW576_15755	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_15760	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_15790	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_15795	COG2261	transglycosylase associated protein
HW576_15825	COG1027	Aspartate ammonia-lyase
HW576_15830	COG0252	asparaginase activity
HW576_15835	COG1396	sequence-specific DNA binding
HW576_15855	COG0640	Transcriptional regulator
HW576_15875	COG0531	amino acid
HW576_15880	COG1959	2 iron, 2 sulfur cluster binding
HW576_15900	COG0281	malic enzyme
HW576_15905	COG2746	aminoglycoside 3-N-acetyltransferase activity
HW576_15915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_15920	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_15930	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW576_15935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HW576_15950	COG0477	Major facilitator Superfamily
HW576_15955	COG1846	Transcriptional regulator
HW576_15960	COG0789	Transcriptional regulator
HW576_15965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_16000	COG1819	glycosyl
HW576_16020	COG1902	pentaerythritol trinitrate reductase activity
HW576_16030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW576_16045	COG2814	Major facilitator Superfamily
HW576_16055	COG1228	amidohydrolase
HW576_16065	COG1316	TRANSCRIPTIONal
HW576_16070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_16090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HW576_16100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW576_16170	COG1280	lysine exporter protein (LysE YggA)
HW576_16180	COG0531	amino acid
HW576_16195	COG3764	Sortase (surface protein transpeptidase)
HW576_16200	COG0730	response to heat
HW576_16205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_16210	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HW576_16220	COG2130	NADP-dependent
HW576_16245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_16260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HW576_16270	COG0501	Belongs to the peptidase M48B family
HW576_16310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HW576_16310	COG0131	Imidazoleglycerol-phosphate dehydratase
HW576_16325	COG2076	Multidrug Resistance protein
HW576_16330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HW576_16335	COG1278	Cold shock
HW576_16340	COG2323	membrane
HW576_16355	COG2910	NAD(P)H-binding
HW576_16380	COG4607	ABC-type enterochelin transport system periplasmic component
HW576_16385	COG4604	ABC transporter, ATP-binding protein
HW576_16390	COG4605	iron ion homeostasis
HW576_16395	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW576_16400	COG3773	Cell wall hydrolase
HW576_16425	COG1063	alcohol dehydrogenase
HW576_16430	COG3775	system Galactitol-specific IIC component
HW576_16435	COG3414	Phosphotransferase system galactitol-specific IIB component
HW576_16440	COG3414	Phosphotransferase system galactitol-specific IIB component
HW576_16455	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW576_16460	COG0681	Belongs to the peptidase S26 family
HW576_16480	COG1349	DNA-binding transcription factor activity
HW576_16495	COG1193	negative regulation of DNA recombination
HW576_16505	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HW576_16510	COG1396	sequence-specific DNA binding
HW576_16515	COG0861	Integral membrane protein TerC family
HW576_16520	COG1609	Transcriptional regulator
HW576_16525	COG1959	2 iron, 2 sulfur cluster binding
HW576_16585	COG3773	Cell wall hydrolase
HW576_16590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW576_16615	COG3546	catalase activity
HW576_16635	COG1280	lysine exporter protein (LysE YggA)
HW576_16640	COG1917	Cupin 2, conserved barrel domain protein
HW576_16640	COG2207	Transcriptional regulator
HW576_16645	COG4585	Histidine kinase
HW576_16665	COG3209	COG3209 Rhs family protein
HW576_16685	COG1819	glycosyl
HW576_16690	COG0456	acetyltransferase
HW576_16705	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HW576_16715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW576_16735	COG0346	lactoylglutathione lyase activity
HW576_16740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW576_16755	COG1136	(ABC) transporter
HW576_16760	COG0577	efflux transmembrane transporter activity
HW576_16765	COG5002	protein histidine kinase activity
HW576_16765	COG3850	Histidine kinase
HW576_16790	COG5002	protein histidine kinase activity
HW576_16795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_16800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW576_16825	COG4989	oxidoreductase activity
HW576_16835	COG0697	spore germination
HW576_16840	COG1917	Cupin 2, conserved barrel domain protein
HW576_16840	COG2207	Transcriptional regulator
HW576_16915	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HW576_16925	COG1301	dicarboxylic acid transport
HW576_16930	COG2824	Alkylphosphonate utilization operon protein PhnA
HW576_16960	COG0405	Gamma-glutamyltransferase
HW576_16965	COG1073	alpha beta
HW576_16980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW576_16985	COG4521	taurine ABC transporter
HW576_16990	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HW576_16995	COG2175	clavaminate synthase activity
HW576_17000	COG2814	Major facilitator Superfamily
HW576_17020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_17030	COG1960	acyl-CoA dehydrogenase activity
HW576_17035	COG0604	alcohol dehydrogenase
HW576_17040	COG0745	RESPONSE REGULATOR receiver
HW576_17045	COG2205	protein histidine kinase activity
HW576_17050	COG1136	(ABC) transporter
HW576_17055	COG0577	efflux transmembrane transporter activity
HW576_17065	COG0412	Dienelactone hydrolase
HW576_17070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_17080	COG0730	response to heat
HW576_17085	COG0425	Belongs to the sulfur carrier protein TusA family
HW576_17090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW576_17090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW576_17095	COG0425	Belongs to the sulfur carrier protein TusA family
HW576_17095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW576_17110	COG2210	Belongs to the sulfur carrier protein TusA family
HW576_17115	COG0425	Belongs to the sulfur carrier protein TusA family
HW576_17120	COG1937	Protein conserved in bacteria
HW576_17145	COG0583	DNA-binding transcription factor activity
HW576_17165	COG2188	Transcriptional regulator
HW576_17175	COG2723	6-phospho-beta-galactosidase activity
HW576_17205	COG1280	lysine exporter protein (LysE YggA)
HW576_17225	COG0583	DNA-binding transcription factor activity
HW576_17230	COG2814	Major facilitator Superfamily
HW576_17235	COG0346	lactoylglutathione lyase activity
HW576_17250	COG2723	6-phospho-beta-galactosidase activity
HW576_17255	COG1263	PTS System
HW576_17255	COG2190	(PTS) system
HW576_17255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW576_17260	COG3711	transcriptional antiterminator
HW576_17265	COG3706	GGDEF domain
HW576_17270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HW576_17290	COG0778	Nitroreductase
HW576_17295	COG1012	belongs to the aldehyde dehydrogenase family
HW576_17315	COG1704	LemA family
HW576_17335	COG1733	regulation of RNA biosynthetic process
HW576_17340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HW576_17345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HW576_17350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW576_17365	COG2304	oxidoreductase activity
HW576_17375	COG0346	lactoylglutathione lyase activity
HW576_17380	COG2808	Putative FMN-binding domain
HW576_17420	COG4807	Protein conserved in bacteria
HW576_17430	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HW576_17435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_17440	COG1278	Cold shock
HW576_17450	COG1278	Cold shock
HW576_17465	COG0747	negative chemotaxis
HW576_17470	COG0601	transmembrane transport
HW576_17475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW576_17480	COG0444	Belongs to the ABC transporter superfamily
HW576_17485	COG4608	Belongs to the ABC transporter superfamily
HW576_17495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HW576_17500	COG1301	dicarboxylic acid transport
HW576_17515	COG0477	Major facilitator Superfamily
HW576_17560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW576_17565	COG0659	secondary active sulfate transmembrane transporter activity
HW576_17575	COG2211	Major facilitator Superfamily
HW576_17580	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HW576_17585	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HW576_17590	COG1691	(AIR) carboxylase
HW576_17595	COG1606	tRNA processing
HW576_17600	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_17610	COG1904	glucuronate isomerase
HW576_17690	COG0561	phosphatase activity
HW576_17700	COG2312	Erythromycin esterase
HW576_17715	COG2329	Antibiotic biosynthesis monooxygenase
HW576_17755	COG3655	Transcriptional regulator
HW576_17765	COG0583	DNA-binding transcription factor activity
HW576_17770	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_17785	COG1609	Transcriptional regulator
HW576_17790	COG1082	Xylose isomerase domain protein TIM barrel
HW576_17795	COG0673	inositol 2-dehydrogenase activity
HW576_17815	COG3718	enzyme involved in inositol metabolism
HW576_17820	COG3962	Belongs to the TPP enzyme family
HW576_17825	COG1349	DNA-binding transcription factor activity
HW576_17830	COG0191	fructose-bisphosphate aldolase activity
HW576_17835	COG1082	Xylose isomerase domain protein TIM barrel
HW576_17840	COG2814	Major facilitator Superfamily
HW576_17855	COG1064	alcohol dehydrogenase
HW576_17860	COG0789	Transcriptional regulator
HW576_17875	COG0662	Cupin 2, conserved barrel domain protein
HW576_17890	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_17895	COG1278	Cold shock
HW576_17915	COG1876	peptidase activity
HW576_17935	COG0598	Magnesium transport protein CorA
HW576_17940	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_17950	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_17965	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_17975	COG4335	DNA alkylation repair
HW576_17980	COG0454	-acetyltransferase
HW576_18000	COG2814	Major facilitator Superfamily
HW576_18005	COG3848	Pyruvate phosphate dikinase
HW576_18005	COG0574	Belongs to the PEP-utilizing enzyme family
HW576_18010	COG3848	Pyruvate phosphate dikinase
HW576_18010	COG0574	Belongs to the PEP-utilizing enzyme family
HW576_18025	COG2186	Transcriptional regulator
HW576_18045	COG3619	membrane
HW576_18055	COG1349	DNA-binding transcription factor activity
HW576_18060	COG0561	phosphatase activity
HW576_18070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW576_18090	COG1280	lysine exporter protein (LysE YggA)
HW576_18125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HW576_18145	COG2814	Major facilitator Superfamily
HW576_18150	COG2160	L-arabinose isomerase activity
HW576_18165	COG1609	Transcriptional regulator
HW576_18170	COG1078	dGTPase activity
HW576_18190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW576_18195	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW576_18200	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW576_18200	COG1918	ferrous iron import across plasma membrane
HW576_18235	COG1846	Transcriptional regulator
HW576_18270	COG0697	spore germination
HW576_18275	COG1388	LysM domain
HW576_18275	COG0791	NLP P60 protein
HW576_18280	COG2258	MOSC domain
HW576_18285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HW576_18320	COG4974	Belongs to the 'phage' integrase family
HW576_18365	COG1309	transcriptional regulator
HW576_18370	COG3844	kynureninase activity
HW576_18375	COG1113	amino acid transport
HW576_18380	COG3483	tryptophan 2,3-dioxygenase activity
HW576_18385	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HW576_18390	COG1942	4-Oxalocrotonate Tautomerase
HW576_18420	COG0251	oxidation-reduction process
HW576_18435	COG0431	NADPH-dependent FMN reductase
HW576_18440	COG0196	riboflavin kinase activity
HW576_18445	COG2368	4-hydroxyphenylacetate
HW576_18465	COG0789	Transcriptional regulator
HW576_18500	COG5646	InterPro IPR014922
HW576_18535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW576_18545	COG2258	MOSC domain
HW576_18560	COG0477	Major facilitator Superfamily
HW576_18565	COG0583	DNA-binding transcription factor activity
HW576_18570	COG2070	2-Nitropropane dioxygenase
HW576_18575	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HW576_18585	COG1376	ErfK ybiS ycfS ynhG family protein
HW576_18595	COG2271	Major facilitator Superfamily
HW576_18600	COG4948	Mandelate Racemase Muconate Lactonizing
HW576_18610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW576_18615	COG1414	Transcriptional regulator
HW576_18620	COG1476	TRANSCRIPTIONal
HW576_18655	COG1012	belongs to the aldehyde dehydrogenase family
HW576_18660	COG2188	Transcriptional regulator
HW576_18670	COG1501	Belongs to the glycosyl hydrolase 31 family
HW576_18680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW576_18690	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HW576_18700	COG0300	oxidoreductase activity
HW576_18710	COG0596	Alpha beta hydrolase
HW576_18710	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW576_18715	COG1309	transcriptional regulator
HW576_18725	COG1733	regulation of RNA biosynthetic process
HW576_18730	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW576_18735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW576_18740	COG2226	methyltransferase
HW576_18755	COG1942	4-Oxalocrotonate Tautomerase
HW576_18760	COG0583	DNA-binding transcription factor activity
HW576_18770	COG1522	sequence-specific DNA binding
HW576_18780	COG2267	carboxylic ester hydrolase activity
HW576_18790	COG1335	isochorismatase
HW576_18800	COG0346	lactoylglutathione lyase activity
HW576_18805	COG2259	Doxx family
HW576_18830	COG1309	transcriptional regulator
HW576_18835	COG2076	Multidrug Resistance protein
HW576_18875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HW576_18885	COG2851	Citrate transporter
HW576_18895	COG0477	Major facilitator Superfamily
HW576_18905	COG0477	Major facilitator Superfamily
HW576_18910	COG1309	transcriptional regulator
HW576_18930	COG2318	DinB family
HW576_18935	COG0156	8-amino-7-oxononanoate synthase activity
HW576_18940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HW576_18960	COG1378	Sugar-specific transcriptional regulator TrmB
HW576_18965	COG0697	spore germination
HW576_18975	COG0583	DNA-binding transcription factor activity
HW576_19020	COG1266	CAAX protease self-immunity
HW576_19040	COG0252	asparaginase activity
HW576_19060	COG1695	Transcriptional regulator
HW576_19070	COG0656	L-ascorbic acid biosynthetic process
HW576_19080	COG0583	DNA-binding transcription factor activity
HW576_19095	COG2814	Major facilitator Superfamily
HW576_19100	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_19120	COG1309	transcriptional regulator
HW576_19190	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HW576_19255	COG3339	Conserved Protein
HW576_19270	COG3708	Transcriptional regulator
HW576_19270	COG2207	Transcriptional regulator
HW576_19285	COG1357	PFAM Pentapeptide repeats (8 copies)
HW576_19295	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW576_19300	COG1733	regulation of RNA biosynthetic process
HW576_19340	COG0303	'Molybdopterin
HW576_19350	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW576_19355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HW576_19385	COG2244	polysaccharide biosynthetic process
HW576_19405	COG2828	Protein conserved in bacteria
HW576_19410	COG0583	DNA-binding transcription factor activity
HW576_19415	COG2851	Citrate transporter
HW576_19440	COG0670	Belongs to the BI1 family
HW576_19460	COG0791	NLP P60 protein
HW576_19465	COG2814	Major facilitator Superfamily
HW576_19470	COG1846	Transcriptional regulator
HW576_19490	COG1278	Cold shock
HW576_19505	COG1113	amino acid transport
HW576_19510	COG1113	amino acid transport
HW576_19515	COG1012	belongs to the aldehyde dehydrogenase family
HW576_19520	COG0506	proline dehydrogenase activity
HW576_19525	COG3878	Protein conserved in bacteria
HW576_19545	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW576_19555	COG5001	Diguanylate cyclase
HW576_19555	COG3300	MHYT domain
HW576_19610	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HW576_19615	COG5609	conserved protein (DUF2294)
HW576_19625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW576_19655	COG0454	-acetyltransferase
HW576_19680	COG0789	Transcriptional regulator
HW576_19685	COG0667	Aldo Keto reductase
HW576_19695	COG0789	Transcriptional regulator
HW576_19720	COG1621	beta-fructofuranosidase activity
HW576_19725	COG4980	gas vesicle protein
HW576_19750	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW576_19755	COG0577	efflux transmembrane transporter activity
HW576_19760	COG1136	(ABC) transporter
HW576_19770	COG0642	Histidine kinase
HW576_19785	COG1289	transmembrane transporter activity
HW576_19790	COG1937	Protein conserved in bacteria
HW576_19795	COG3209	COG3209 Rhs family protein
HW576_19805	COG3973	AAA domain
HW576_19810	COG1024	Enoyl-CoA hydratase
HW576_19815	COG1733	regulation of RNA biosynthetic process
HW576_19830	COG2124	cytochrome p450
HW576_19835	COG2259	Doxx family
HW576_19840	COG0463	Glycosyl transferase, family 2
HW576_19850	COG0463	Glycosyl transferase, family 2
HW576_19865	COG0791	NLP P60 protein
HW576_19865	COG1388	LysM domain
HW576_19870	COG0840	transmembrane signaling receptor activity
HW576_19875	COG1846	Transcriptional regulator
HW576_19885	COG1595	DNA-templated transcription, initiation
HW576_19890	COG0726	polysaccharide deacetylase
HW576_19910	COG0833	amino acid
HW576_19925	COG0405	Gamma-glutamyltransferase
HW576_19945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW576_19950	COG0569	domain protein
HW576_19960	COG1522	sequence-specific DNA binding
HW576_19970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW576_19975	COG0745	RESPONSE REGULATOR receiver
HW576_19980	COG2770	Histidine kinase
HW576_19980	COG2205	protein histidine kinase activity
HW576_19985	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HW576_19990	COG1607	acyl-coa hydrolase
HW576_19995	COG1802	Transcriptional regulator
HW576_20000	COG0697	spore germination
HW576_20010	COG0006	proline dipeptidase activity
HW576_20030	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW576_20035	COG5522	Integral membrane protein (intg_mem_TP0381)
HW576_20045	COG1174	glycine betaine transport
HW576_20050	COG1125	glycine betaine transport
HW576_20050	COG0517	IMP dehydrogenase activity
HW576_20065	COG2814	Major facilitator Superfamily
HW576_20075	COG0395	ABC-type sugar transport system, permease component
HW576_20095	COG1609	Transcriptional regulator
HW576_20100	COG2205	protein histidine kinase activity
HW576_20105	COG0730	response to heat
HW576_20110	COG1301	dicarboxylic acid transport
HW576_20150	COG1368	sulfuric ester hydrolase activity
HW576_20160	COG0697	spore germination
HW576_20165	COG1902	pentaerythritol trinitrate reductase activity
HW576_20180	COG1113	amino acid transport
HW576_20185	COG5505	Protein of unknown function (DUF819)
HW576_20190	COG1309	transcriptional regulator
HW576_20200	COG0583	DNA-binding transcription factor activity
HW576_20205	COG0730	response to heat
HW576_20210	COG1247	-acetyltransferase
HW576_20215	COG2910	NAD(P)H-binding
HW576_20225	COG1285	pathogenesis
HW576_20235	COG4195	phage-related replication protein
HW576_20240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_20255	COG1113	amino acid transport
HW576_20285	COG0463	Glycosyl transferase, family 2
HW576_20310	COG2514	catechol 2,3-dioxygenase activity
HW576_20330	COG1280	lysine exporter protein (LysE YggA)
HW576_20335	COG1115	amino acid carrier protein
HW576_20345	COG0385	Bile acid
HW576_20350	COG0668	transmembrane transport
HW576_20355	COG2340	Cysteine-rich secretory protein family
HW576_20360	COG1253	flavin adenine dinucleotide binding
HW576_20370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HW576_20375	COG0589	response to stress
HW576_20385	COG0205	6-phosphofructokinase activity
HW576_20390	COG0791	NLP P60 protein
HW576_20390	COG1388	LysM domain
HW576_20400	COG0432	Pfam Uncharacterised protein family UPF0047
HW576_20405	COG0697	spore germination
HW576_20410	COG0814	amino acid
HW576_20435	COG1131	(ABC) transporter
HW576_20450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW576_20465	COG0584	glycerophosphoryl diester phosphodiesterase
HW576_20475	COG1131	(ABC) transporter
HW576_20500	COG1263	PTS System
HW576_20500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW576_20505	COG3711	transcriptional antiterminator
HW576_20510	COG2190	(PTS) system
HW576_20515	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HW576_20530	COG0772	Belongs to the SEDS family
HW576_20535	COG0659	secondary active sulfate transmembrane transporter activity
HW576_20540	COG0813	purine-nucleoside phosphorylase activity
HW576_20555	COG0671	phosphoesterase, PA-phosphatase related
HW576_20560	COG4326	sporulation control protein
HW576_20565	COG0515	serine threonine protein kinase
HW576_20590	COG4479	Belongs to the UPF0346 family
HW576_20595	COG3594	Acyltransferase
HW576_20610	COG1509	lysine 2,3-aminomutase activity
HW576_20615	COG0456	acetyltransferase
HW576_20620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW576_20625	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HW576_20630	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW576_20635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW576_20640	COG1301	dicarboxylic acid transport
HW576_20650	COG4191	Histidine kinase
HW576_20680	COG2755	lipolytic protein G-D-S-L family
HW576_20685	COG1999	signal sequence binding
HW576_20695	COG1307	EDD domain protein, DegV family
HW576_20705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW576_20715	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW576_20720	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HW576_20725	COG0788	formyltetrahydrofolate deformylase activity
HW576_20760	COG0076	glutamate decarboxylase activity
HW576_20780	COG0415	Belongs to the DNA photolyase family
HW576_20785	COG3852	Histidine kinase
HW576_20805	COG1012	belongs to the aldehyde dehydrogenase family
HW576_20815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HW576_20825	COG4846	Membrane protein involved in cytochrome C biogenesis
HW576_20830	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HW576_20835	COG0785	Cytochrome C biogenesis protein
HW576_20845	COG1132	(ABC) transporter
HW576_20850	COG1132	(ABC) transporter
HW576_20870	COG4224	UPF0291 protein
HW576_20875	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW576_20900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW576_20905	COG0531	amino acid
HW576_20915	COG0174	glutamine synthetase
HW576_20920	COG0789	Transcriptional regulator
HW576_20925	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HW576_20930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW576_20935	COG2860	membrane
HW576_20940	COG0464	growth
HW576_20950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HW576_20960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HW576_20965	COG0531	amino acid
HW576_20975	COG4550	Control of competence regulator ComK, YlbF/YmcA
HW576_20980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW576_20985	COG1013	pyruvate-flavodoxin oxidoreductase activity
HW576_20990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HW576_20990	COG0674	pyruvate-flavodoxin oxidoreductase activity
HW576_21005	COG2359	stage V sporulation protein S
HW576_21010	COG1692	metallophosphoesterase
HW576_21020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HW576_21025	COG1546	Belongs to the CinA family
HW576_21025	COG1058	Belongs to the CinA family
HW576_21030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW576_21035	COG1426	Protein conserved in bacteria
HW576_21050	COG0300	oxidoreductase activity
HW576_21055	COG0612	Peptidase, M16
HW576_21060	COG0612	Peptidase, M16
HW576_21085	COG2188	Transcriptional regulator
HW576_21090	COG4980	gas vesicle protein
HW576_21090	COG1674	ftsk spoiiie
HW576_21100	COG0740	serine-type endopeptidase activity
HW576_21105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW576_21115	COG0527	aspartate kinase activity
HW576_21120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HW576_21125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW576_21130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW576_21135	COG1873	PFAM PRC-barrel domain
HW576_21140	COG0612	Peptidase, M16
HW576_21145	COG0726	polysaccharide deacetylase
HW576_21150	COG1185	polyribonucleotide nucleotidyltransferase activity
HW576_21155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HW576_21160	COG0196	riboflavin kinase activity
HW576_21170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HW576_21175	COG1550	Protein conserved in bacteria
HW576_21185	COG1358	cellular component organization or biogenesis
HW576_21190	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HW576_21195	COG0195	Participates in both transcription termination and antitermination
HW576_21200	COG0779	Required for maturation of 30S ribosomal subunits
HW576_21205	COG2176	DNA-directed DNA polymerase activity
HW576_21210	COG0442	prolyl-tRNA aminoacylation
HW576_21215	COG0750	zinc metalloprotease
HW576_21225	COG4589	Belongs to the CDS family
HW576_21235	COG0233	cytoplasmic translational termination
HW576_21245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HW576_21260	COG1191	sigma factor activity
HW576_21265	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HW576_21270	COG0835	chemotaxis
HW576_21275	COG0643	Histidine kinase
HW576_21275	COG2198	Histidine kinase
HW576_21280	COG2201	protein-glutamate methylesterase activity
HW576_21285	COG0455	bacterial-type flagellum organization
HW576_21290	COG1419	protein localization to endoplasmic reticulum
HW576_21295	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW576_21300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW576_21305	COG1684	flagellar biosynthetic protein fliR
HW576_21310	COG1987	bacterial-type flagellum assembly
HW576_21315	COG1338	Plays a role in the flagellum-specific transport system
HW576_21320	COG3190	flagellar
HW576_21325	COG2201	protein-glutamate methylesterase activity
HW576_21330	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW576_21330	COG1776	CheC inhibitor of MCP methylation
HW576_21335	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW576_21345	COG1582	Flagellar protein (FlbD)
HW576_21350	COG4786	Flagellar basal body rod
HW576_21355	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HW576_21370	COG2882	bacterial-type flagellum organization
HW576_21375	COG1157	protein secretion by the type III secretion system
HW576_21380	COG1317	bacterial-type flagellum organization
HW576_21385	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW576_21390	COG1766	The M ring may be actively involved in energy transduction
HW576_21395	COG1677	Flagellar hook-basal body complex protein FliE
HW576_21400	COG1558	bacterial-type flagellum-dependent cell motility
HW576_21405	COG1815	bacterial-type flagellum-dependent cell motility
HW576_21410	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HW576_21415	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HW576_21425	COG4974	Belongs to the 'phage' integrase family
HW576_21430	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HW576_21435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW576_21440	COG0758	DNA mediated transformation
HW576_21445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HW576_21450	COG0045	succinate-CoA ligase (ADP-forming) activity
HW576_21470	COG0335	large ribosomal subunit rRNA binding
HW576_21480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HW576_21490	COG1837	Belongs to the UPF0109 family
HW576_21495	COG0228	four-way junction DNA binding
HW576_21500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HW576_21510	COG0552	protein localization to endoplasmic reticulum
HW576_21515	COG1196	nuclear chromosome segregation
HW576_21520	COG0571	ribonuclease III activity
HW576_21530	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_21535	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW576_21540	COG0416	fatty acid biosynthetic process
HW576_21545	COG1349	DNA-binding transcription factor activity
HW576_21550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW576_21555	COG1760	l-serine dehydratase
HW576_21560	COG1760	l-serine dehydratase
HW576_21570	COG1461	Dihydroxyacetone kinase
HW576_21575	COG1302	Protein conserved in bacteria
HW576_21580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW576_21590	COG1564	THIamine pyrophosphokinase
HW576_21595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW576_21600	COG1162	GTPase activity
HW576_21605	COG2815	serine threonine protein kinase
HW576_21605	COG0515	serine threonine protein kinase
HW576_21610	COG0631	protein serine/threonine phosphatase activity
HW576_21620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW576_21620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HW576_21625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HW576_21635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HW576_21640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW576_21645	COG1758	RNA polymerase activity
HW576_21650	COG0194	GDP metabolic process
HW576_21655	COG2052	Domain of unknown function (DUF370)
HW576_21660	COG1561	YicC-like family, N-terminal region
HW576_21665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HW576_21675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HW576_21705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HW576_21710	COG0540	Belongs to the ATCase OTCase family
HW576_21720	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HW576_21725	COG0564	pseudouridine synthase activity
HW576_21730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW576_21745	COG3599	regulation of cell shape
HW576_21750	COG2302	S4 RNA-binding domain
HW576_21755	COG0762	integral membrane protein
HW576_21760	COG1799	cell septum assembly
HW576_21765	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HW576_21775	COG1873	PFAM PRC-barrel domain
HW576_21780	COG1191	sigma factor activity
HW576_21785	COG1191	sigma factor activity
HW576_21795	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW576_21800	COG0849	cell division
HW576_21805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HW576_21810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HW576_21815	COG0772	Belongs to the SEDS family
HW576_21820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HW576_21825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW576_21830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW576_21835	COG0768	penicillin binding
HW576_21845	COG4839	cell division protein FtsL
HW576_21855	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HW576_21865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW576_21870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW576_21875	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HW576_21880	COG0439	Biotin carboxylase
HW576_21885	COG0454	-acetyltransferase
HW576_21895	COG1024	Enoyl-CoA hydratase
HW576_21900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HW576_21905	COG1399	metal-binding, possibly nucleic acid-binding protein
HW576_21910	COG1323	Belongs to the UPF0348 family
HW576_21915	COG3480	Lon protease (S16) C-terminal proteolytic domain
HW576_21920	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW576_21925	COG3314	Sporulation integral membrane protein YlbJ
HW576_21930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HW576_21935	COG0742	ribosomal rna small subunit methyltransferase
HW576_21945	COG4471	UPF0298 protein
HW576_21950	COG3679	Belongs to the UPF0342 family
HW576_21970	COG4347	Protein of unknown function (DUF1405)
HW576_21980	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HW576_21995	COG5582	Belongs to the UPF0302 family
HW576_22000	COG0457	Tetratricopeptide repeat
HW576_22005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HW576_22010	COG0287	Prephenate dehydrogenase
HW576_22015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW576_22020	COG0159	tryptophan synthase activity
HW576_22030	COG0135	phosphoribosylanthranilate isomerase activity
HW576_22035	COG0134	indole-3-glycerol-phosphate synthase activity
HW576_22040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW576_22050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HW576_22055	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HW576_22060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HW576_22065	COG0105	UTP biosynthetic process
HW576_22070	COG0142	geranyltranstransferase activity
HW576_22075	COG2226	methyltransferase
HW576_22080	COG0142	geranyltranstransferase activity
HW576_22090	COG0302	gtp cyclohydrolase
HW576_22095	COG0776	regulation of translation
HW576_22100	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HW576_22135	COG2271	Major facilitator Superfamily
HW576_22140	COG1304	FMN binding
HW576_22145	COG0539	negative regulation of cytoplasmic translation
HW576_22155	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HW576_22170	COG2959	enzyme of heme biosynthesis
HW576_22175	COG3409	Peptidoglycan-binding domain 1 protein
HW576_22175	COG3773	Cell wall hydrolase
HW576_22180	COG2339	peptidase activity
HW576_22185	COG0252	asparaginase activity
HW576_22190	COG0492	ferredoxin-NADP+ reductase activity
HW576_22195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW576_22200	COG4862	establishment of competence for transformation
HW576_22205	COG0789	Transcriptional regulator
HW576_22210	COG1408	metallophosphoesterase
HW576_22225	COG1266	CAAX protease self-immunity
HW576_22230	COG0514	ATP-dependent DNA helicase (RecQ)
HW576_22240	COG1141	Ferredoxin
HW576_22245	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HW576_22250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW576_22255	COG0739	heme binding
HW576_22260	COG5002	protein histidine kinase activity
HW576_22265	COG0745	RESPONSE REGULATOR receiver
HW576_22270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW576_22275	COG1333	cytochrome c biogenesis protein
HW576_22280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW576_22285	COG1187	pseudouridine synthase activity
HW576_22290	COG0700	Nucleoside recognition
HW576_22295	COG2715	membrane protein required for spore maturation
HW576_22300	COG1686	Belongs to the peptidase S11 family
HW576_22305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HW576_22310	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HW576_22320	COG1547	Domain of unknown function (DUF309)
HW576_22330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HW576_22335	COG4086	secreted protein
HW576_22345	COG0697	spore germination
HW576_22360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW576_22395	COG1686	Belongs to the peptidase S11 family
HW576_22410	COG4974	Belongs to the 'phage' integrase family
HW576_22420	COG0735	belongs to the Fur family
HW576_22425	COG1300	Membrane
HW576_22430	COG0494	nUDIX hydrolase
HW576_22440	COG0667	Aldo Keto reductase
HW576_22450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HW576_22455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW576_22465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW576_22470	COG1073	alpha beta
HW576_22485	COG0300	oxidoreductase activity
HW576_22490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW576_22495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW576_22500	COG1902	pentaerythritol trinitrate reductase activity
HW576_22510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW576_22515	COG1012	belongs to the aldehyde dehydrogenase family
HW576_22520	COG2508	Transcriptional regulator
HW576_22540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HW576_22540	COG0167	dihydroorotate dehydrogenase activity
HW576_22545	COG0493	'glutamate synthase
HW576_22550	COG2195	Cleaves the N-terminal amino acid of tripeptides
HW576_22555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW576_22560	COG0346	lactoylglutathione lyase activity
HW576_22570	COG1376	ErfK ybiS ycfS ynhG family protein
HW576_22575	COG4129	membrane
HW576_22580	COG1126	abc transporter atp-binding protein
HW576_22585	COG0765	amino acid transport
HW576_22590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW576_22600	COG1703	isobutyryl-CoA mutase activity
HW576_22605	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW576_22605	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW576_22610	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW576_22610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW576_22615	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW576_22620	COG0022	dehydrogenase e1 component
HW576_22625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW576_22630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW576_22645	COG0280	phosphate acetyltransferase
HW576_22650	COG3829	transcription factor binding
HW576_22650	COG3290	protein histidine kinase activity
HW576_22660	COG0584	glycerophosphoryl diester phosphodiesterase
HW576_22665	COG3093	addiction module antidote protein HigA
HW576_22670	COG3104	oligopeptide transport
HW576_22675	COG0745	RESPONSE REGULATOR receiver
HW576_22680	COG0750	zinc metalloprotease
HW576_22685	COG0497	DNA recombination
HW576_22695	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HW576_22710	COG1722	exodeoxyribonuclease VII activity
HW576_22720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW576_22725	COG1302	Protein conserved in bacteria
HW576_22730	COG0439	Biotin carboxylase
HW576_22735	COG0511	ligase activity, forming carbon-carbon bonds
HW576_22775	COG3854	ATPases associated with a variety of cellular activities
HW576_22785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HW576_22790	COG0006	proline dipeptidase activity
HW576_22795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HW576_22805	COG3872	metal-dependent enzyme
HW576_22815	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW576_22820	COG1321	iron dependent repressor
HW576_22825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW576_22830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW576_22835	COG0095	Lipoate-protein ligase
HW576_22840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW576_22850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HW576_22855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HW576_22860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW576_22890	COG4970	Tfp pilus assembly protein FimT
HW576_22895	COG4537	Required for transformation and DNA binding
HW576_22900	COG1459	type II secretion system
HW576_22905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW576_22910	COG1393	Belongs to the ArsC family
HW576_22920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW576_22935	COG1940	carbohydrate kinase activity
HW576_22940	COG4483	Protein conserved in bacteria
HW576_22945	COG0457	Tetratricopeptide repeat
HW576_22945	COG0705	Rhomboid family
HW576_22960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW576_22970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HW576_22985	COG0704	Plays a role in the regulation of phosphate uptake
HW576_23000	COG0477	Major facilitator Superfamily
HW576_23035	COG2839	Protein conserved in bacteria
HW576_23045	COG2814	Major facilitator Superfamily
HW576_23050	COG1388	LysM domain
HW576_23055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HW576_23060	COG4709	membrane
HW576_23065	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HW576_23070	COG0735	belongs to the Fur family
HW576_23075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW576_23080	COG1121	(ABC) transporter
HW576_23090	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HW576_23095	COG0513	Belongs to the DEAD box helicase family
HW576_23105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HW576_23110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HW576_23115	COG2384	SAM-dependent methyltransferase
HW576_23120	COG2010	Cytochrome c
HW576_23125	COG1960	acyl-CoA dehydrogenase activity
HW576_23130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW576_23135	COG0358	DNA primase activity
HW576_23140	COG1671	Belongs to the UPF0178 family
HW576_23145	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HW576_23150	COG0517	IMP dehydrogenase activity
HW576_23165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HW576_23170	COG0295	cytidine deaminase activity
HW576_23175	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HW576_23185	COG1480	7TM receptor with intracellular HD hydrolase
HW576_23190	COG1702	phosphate starvation-inducible protein PhoH
HW576_23215	COG1030	water channel activity
HW576_23220	COG1610	YqeY-like protein
HW576_23230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW576_23235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HW576_23240	COG2264	protein methyltransferase activity
HW576_23255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HW576_23260	COG1420	regulation of RNA biosynthetic process
HW576_23265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW576_23270	COG0481	GTPase activity
HW576_23280	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HW576_23285	COG0268	Binds directly to 16S ribosomal RNA
HW576_23290	COG1466	dna polymerase III delta subunit
HW576_23300	COG2333	competence protein COMEC
HW576_23300	COG0658	competence protein
HW576_23305	COG2131	deaminase
HW576_23310	COG1596	polysaccharide export
HW576_23310	COG1555	photosystem II stabilization
HW576_23315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW576_23320	COG2226	methyltransferase
HW576_23325	COG0799	negative regulation of ribosome biogenesis
HW576_23330	COG1713	HD superfamily hydrolase involved in NAD metabolism
HW576_23335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW576_23340	COG1534	Rna-binding protein
HW576_23345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HW576_23350	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HW576_23355	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HW576_23365	COG0688	phosphatidylethanolamine metabolic process
HW576_23370	COG1183	phosphatidylcholine synthase activity
HW576_23395	COG0626	cystathionine gamma-synthase activity
HW576_23400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW576_23405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW576_23410	COG2226	methyltransferase
HW576_23425	COG0768	penicillin binding
HW576_23430	COG1335	isochorismatase
HW576_23435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW576_23440	COG0572	uridine kinase
HW576_23455	COG4122	O-methyltransferase activity
HW576_23460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW576_23465	COG3906	Belongs to the UPF0473 family
HW576_23475	COG4472	Bacterial protein of unknown function (DUF965)
HW576_23485	COG0628	permease
HW576_23500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW576_23510	COG0482	sulfurtransferase activity
HW576_23515	COG1104	cysteine desulfurase activity
HW576_23520	COG1959	2 iron, 2 sulfur cluster binding
HW576_23525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW576_23530	COG0581	inorganic phosphate transmembrane transporter activity
HW576_23535	COG0573	inorganic phosphate transmembrane transporter activity
HW576_23540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HW576_23545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HW576_23555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HW576_23560	COG0124	histidyl-tRNA synthetase
HW576_23570	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW576_23575	COG1490	D-aminoacyl-tRNA deacylase activity
HW576_23580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW576_23585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW576_23590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HW576_23590	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HW576_23595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW576_23595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW576_23605	COG2244	polysaccharide biosynthetic process
HW576_23610	COG2323	membrane
HW576_23620	COG1862	Preprotein translocase
HW576_23625	COG0343	queuine tRNA-ribosyltransferase activity
HW576_23630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HW576_23640	COG2255	four-way junction helicase activity
HW576_23645	COG0632	four-way junction helicase activity
HW576_23670	COG1388	LysM domain
HW576_23675	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HW576_23680	COG0157	Belongs to the NadC ModD family
HW576_23685	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HW576_23690	COG1104	cysteine desulfurase activity
HW576_23695	COG1827	regulation of RNA biosynthetic process
HW576_23700	COG0077	Prephenate dehydratase
HW576_23705	COG4492	Belongs to the UPF0735 family
HW576_23710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HW576_23715	COG3290	protein histidine kinase activity
HW576_23725	COG2868	ribosomal protein
HW576_23735	COG1530	ribonuclease E activity
HW576_23740	COG1994	Peptidase M50
HW576_23745	COG0739	heme binding
HW576_23750	COG2894	cell division
HW576_23755	COG0850	regulation of cytokinetic process
HW576_23760	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HW576_23765	COG1792	Involved in formation and maintenance of cell shape
HW576_23770	COG1077	Cell shape determining protein MreB Mrl
HW576_23775	COG2003	Belongs to the UPF0758 family
HW576_23780	COG0424	maF-like protein
HW576_23790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HW576_23800	COG2322	membrane
HW576_23805	COG0285	dihydrofolate synthase activity
HW576_23810	COG0525	valine-tRNA ligase activity
HW576_23820	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW576_23825	COG1388	LysM domain
HW576_23830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW576_23835	COG0113	porphobilinogen synthase activity
HW576_23840	COG1587	Uroporphyrinogen-III synthase
HW576_23845	COG0181	hydroxymethylbilane synthase activity
HW576_23850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW576_23865	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HW576_23870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW576_23875	COG1067	ATP-dependent peptidase activity
HW576_23875	COG0470	DNA polymerase III
HW576_23880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HW576_23885	COG0544	peptidyl-prolyl cis-trans isomerase activity
HW576_23890	COG1477	protein flavinylation
HW576_23890	COG0457	Tetratricopeptide repeat
HW576_23895	COG0066	3-isopropylmalate dehydratase activity
HW576_23900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HW576_23910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW576_23915	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HW576_23920	COG0440	acetolactate synthase activity
HW576_23925	COG0028	Belongs to the TPP enzyme family
HW576_23935	COG0622	Phosphoesterase
HW576_23950	COG5401	PFAM Sporulation and spore germination
HW576_23955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HW576_23960	COG1846	Transcriptional regulator
HW576_23970	COG0306	phosphate transporter
HW576_23975	COG1392	Phosphate transport regulator
HW576_23980	COG0768	penicillin binding
HW576_23990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW576_23995	COG0431	NADPH-dependent FMN reductase
HW576_24000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW576_24005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW576_24010	COG1116	anion transmembrane transporter activity
HW576_24015	COG0475	glutathione-regulated potassium exporter activity
HW576_24020	COG0490	domain, Protein
HW576_24030	COG2197	response regulator
HW576_24035	COG0824	Thioesterase
HW576_24040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HW576_24045	COG1053	succinate dehydrogenase
HW576_24050	COG2009	succinate dehydrogenase
HW576_24055	COG1719	4-vinyl reductase, 4VR
HW576_24060	COG0527	aspartate kinase activity
HW576_24070	COG3118	belongs to the thioredoxin family
HW576_24075	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HW576_24080	COG2086	electron transfer activity
HW576_24085	COG1024	Enoyl-CoA hydratase
HW576_24090	COG1309	transcriptional regulator
HW576_24095	COG0318	PFAM AMP-dependent synthetase and ligase
HW576_24100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HW576_24105	COG3766	membrane
HW576_24110	COG1193	negative regulation of DNA recombination
HW576_24115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HW576_24115	COG1796	DNA polymerase
HW576_24120	COG1286	toxin biosynthetic process
HW576_24125	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HW576_24130	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HW576_24135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW576_24135	COG0072	phenylalanine-tRNA ligase activity
HW576_24140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HW576_24145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW576_24155	COG1363	Peptidase, m42
HW576_24175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HW576_24180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HW576_24185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HW576_24190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW576_24200	COG1484	DNA-dependent DNA replication
HW576_24205	COG3611	Membrane attachment protein
HW576_24210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW576_24220	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HW576_24225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HW576_24230	COG0237	dephospho-CoA kinase activity
HW576_24235	COG1971	Probably functions as a manganese efflux pump
HW576_24240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HW576_24245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW576_24245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW576_24250	COG5002	protein histidine kinase activity
HW576_24255	COG0745	RESPONSE REGULATOR receiver
HW576_24265	COG0039	L-malate dehydrogenase activity
HW576_24270	COG0538	isocitrate dehydrogenase activity
HW576_24275	COG0372	Belongs to the citrate synthase family
HW576_24280	COG2707	UPF0756 membrane protein
HW576_24285	COG0628	permease
HW576_24290	COG3030	protein affecting phage T7 exclusion by the F plasmid
HW576_24300	COG0825	malonyl-CoA metabolic process
HW576_24305	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HW576_24310	COG2186	Transcriptional regulator
HW576_24315	COG0281	malic enzyme
HW576_24320	COG0587	DNA-directed DNA polymerase activity
HW576_24335	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HW576_24345	COG4109	DRTGG domain
HW576_24360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HW576_24375	COG0165	Argininosuccinate lyase
HW576_24380	COG0137	argininosuccinate synthase activity
HW576_24395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HW576_24400	COG0827	DNA restriction-modification system
HW576_24405	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HW576_24410	COG3874	Sporulation protein YtfJ
HW576_24420	COG1714	RDD family
HW576_24425	COG0616	signal peptide processing
HW576_24430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HW576_24435	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HW576_24445	COG0301	tRNA thio-modification
HW576_24450	COG1104	cysteine desulfurase activity
HW576_24455	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HW576_24460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HW576_24465	COG1309	transcriptional regulator
HW576_24470	COG1956	GAF domain-containing protein
HW576_24485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW576_24490	COG0454	-acetyltransferase
HW576_24495	COG0517	IMP dehydrogenase activity
HW576_24500	COG0123	including yeast histone deacetylase and acetoin utilization protein
HW576_24520	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HW576_24520	COG1605	Chorismate mutase
HW576_24525	COG3118	belongs to the thioredoxin family
HW576_24530	COG4980	gas vesicle protein
HW576_24545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW576_24555	COG1674	ftsk spoiiie
HW576_24560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW576_24565	COG4848	Belongs to the UPF0354 family
HW576_24570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW576_24575	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HW576_24580	COG1363	Peptidase, m42
HW576_24585	COG5584	Small secreted protein
HW576_24590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW576_24595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HW576_24605	COG0510	thiamine kinase activity
HW576_24610	COG1523	belongs to the glycosyl hydrolase 13 family
HW576_24620	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HW576_24625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW576_24630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW576_24635	COG1349	DNA-binding transcription factor activity
HW576_24640	COG1187	pseudouridine synthase activity
HW576_24645	COG2244	polysaccharide biosynthetic process
HW576_24650	COG2081	HI0933 family
HW576_24660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW576_24665	COG0495	leucyl-tRNA aminoacylation
HW576_24675	COG2610	gluconate transmembrane transporter activity
HW576_24680	COG2814	Major facilitator Superfamily
HW576_24695	COG1242	4 iron, 4 sulfur cluster binding
HW576_24700	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HW576_24710	COG2267	carboxylic ester hydrolase activity
HW576_24715	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HW576_24720	COG0671	phosphoesterase, PA-phosphatase related
HW576_24725	COG0438	transferase activity, transferring glycosyl groups
HW576_24730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HW576_24735	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HW576_24745	COG1506	peptidase
HW576_24750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW576_24755	COG1116	anion transmembrane transporter activity
HW576_24760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW576_24765	COG0494	nUDIX hydrolase
HW576_24775	COG4824	toxin secretion phage lysis holin
HW576_24780	COG0783	Belongs to the Dps family
HW576_24790	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HW576_24795	COG0288	reversible hydration of carbon dioxide
HW576_24800	COG0523	cobalamin synthesis protein
HW576_24810	COG0254	rRNA binding
HW576_24815	COG1271	oxidase subunit
HW576_24820	COG1294	oxidase, subunit
HW576_24825	COG0716	FMN binding
HW576_24850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW576_24855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW576_24860	COG4948	Mandelate Racemase Muconate Lactonizing
HW576_24865	COG0318	PFAM AMP-dependent synthetase and ligase
HW576_24870	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HW576_24875	COG0596	Alpha beta hydrolase
HW576_24880	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HW576_24885	COG1169	isochorismate synthase
HW576_24890	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW576_24900	COG0058	SHG alpha-glucan phosphorylase activity
HW576_24905	COG0297	glycogen (starch) synthase activity
HW576_24910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HW576_24915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HW576_25045	COG0318	PFAM AMP-dependent synthetase and ligase
HW576_25050	COG1285	pathogenesis
HW576_25070	COG0529	Catalyzes the synthesis of activated sulfate
HW576_25080	COG0306	phosphate transporter
HW576_25090	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HW576_25095	COG0346	lactoylglutathione lyase activity
HW576_25100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW576_25110	COG0166	Belongs to the GPI family
HW576_25120	COG2111	Na H antiporter
HW576_25120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW576_25125	COG2111	Na H antiporter
HW576_25130	COG1006	Multisubunit Na H antiporter MnhC subunit
HW576_25135	COG0651	ATP synthesis coupled electron transport
HW576_25140	COG1863	multisubunit Na H antiporter MnhE subunit
HW576_25145	COG2212	antiporter activity
HW576_25150	COG1320	monovalent cation:proton antiporter activity
HW576_25155	COG1979	alcohol dehydrogenase
HW576_25160	COG2155	Conserved Protein
HW576_25165	COG1098	S1 RNA binding domain
HW576_25170	COG0436	Aminotransferase
HW576_25175	COG1522	sequence-specific DNA binding
HW576_25180	COG2267	carboxylic ester hydrolase activity
HW576_25185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HW576_25190	COG2032	superoxide dismutase activity
HW576_25205	COG5018	Exonuclease
HW576_25210	COG2050	protein possibly involved in aromatic compounds catabolism
HW576_25220	COG1418	mRNA catabolic process
HW576_25230	COG2056	Na+-H+ antiporter family
HW576_25235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HW576_25240	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HW576_25245	COG3584	3D domain protein
HW576_25255	COG1252	NADH dehydrogenase
HW576_25260	COG0492	ferredoxin-NADP+ reductase activity
HW576_25270	COG0316	Belongs to the HesB IscA family
HW576_25275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HW576_25280	COG4844	belongs to the
HW576_25285	COG1252	NADH dehydrogenase
HW576_25290	COG4837	Protein of unknown function (DUF1462)
HW576_25295	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HW576_25300	COG0083	homoserine kinase activity
HW576_25305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HW576_25310	COG0460	homoserine dehydrogenase
HW576_25315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW576_25320	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW576_25325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HW576_25330	COG0647	UMP catabolic process
HW576_25335	COG2445	Protein of unknown function DUF86
HW576_25345	COG4470	Protein conserved in bacteria
HW576_25355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HW576_25360	COG0739	heme binding
HW576_25370	COG0733	neurotransmitter:sodium symporter activity
HW576_25380	COG3377	Domain of unknown function (DUF1805)
HW576_25385	COG1801	Protein of unknown function DUF72
HW576_25390	COG0719	Fe-S assembly protein
HW576_25395	COG0822	iron-sulfur transferase activity
HW576_25400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HW576_25405	COG0719	Fe-S assembly protein
HW576_25410	COG0396	ATPase activity
HW576_25415	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW576_25420	COG1464	Belongs to the NlpA lipoprotein family
HW576_25425	COG2011	ABC-type metal ion transport system permease component
HW576_25430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW576_25435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW576_25440	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HW576_25450	COG0509	glycine decarboxylation via glycine cleavage system
HW576_25455	COG1393	Belongs to the ArsC family
HW576_25460	COG1960	acyl-CoA dehydrogenase activity
HW576_25465	COG0183	Belongs to the thiolase family
HW576_25470	COG1024	Enoyl-CoA hydratase
HW576_25470	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW576_25495	COG1120	ATPase activity
HW576_25500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW576_25505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW576_25510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW576_25525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW576_25530	COG1309	transcriptional regulator
HW576_25540	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_25545	COG0477	Major facilitator Superfamily
HW576_25555	COG5002	protein histidine kinase activity
HW576_25555	COG3850	Histidine kinase
HW576_25560	COG0745	RESPONSE REGULATOR receiver
HW576_25565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW576_25570	COG0671	phosphoesterase, PA-phosphatase related
HW576_25575	COG1846	Transcriptional regulator
HW576_25580	COG0778	Nitroreductase
HW576_25585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HW576_25590	COG0314	molybdopterin synthase activity
HW576_25595	COG1763	Mo-molybdopterin cofactor biosynthetic process
HW576_25600	COG0303	'Molybdopterin
HW576_25605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW576_25610	COG0746	molybdenum cofactor guanylyltransferase activity
HW576_25620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HW576_25625	COG5609	conserved protein (DUF2294)
HW576_25630	COG3383	formate dehydrogenase (NAD+) activity
HW576_25635	COG2427	Protein of unknown function (DUF1641)
HW576_25640	COG0725	ABC transporter, periplasmic molybdate-binding protein
HW576_25645	COG4149	molybdate abc transporter
HW576_25655	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HW576_25660	COG0557	exoribonuclease II activity
HW576_25665	COG1647	Serine aminopeptidase, S33
HW576_25670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW576_25680	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HW576_25710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HW576_25730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW576_25740	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HW576_25745	COG1660	Displays ATPase and GTPase activities
HW576_25750	COG1051	belongs to the nudix hydrolase family
HW576_25755	COG0492	ferredoxin-NADP+ reductase activity
HW576_25760	COG0457	Tetratricopeptide repeat
HW576_25765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HW576_25765	COG0140	phosphoribosyl-ATP diphosphatase activity
HW576_25770	COG0107	imidazoleglycerol-phosphate synthase activity
HW576_25775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HW576_25780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HW576_25785	COG0131	Imidazoleglycerol-phosphate dehydratase
HW576_25790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HW576_25795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HW576_25800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HW576_25805	COG0110	maltose O-acetyltransferase activity
HW576_25810	COG0546	phosphoglycolate phosphatase activity
HW576_25815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HW576_25820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HW576_25825	COG1950	PFAM Membrane protein of
HW576_25830	COG1983	PspC domain protein
HW576_25835	COG3595	metallopeptidase activity
HW576_25845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HW576_25850	COG0556	nucleotide-excision repair
HW576_25855	COG2204	response regulator
HW576_25860	COG1012	belongs to the aldehyde dehydrogenase family
HW576_25865	COG0506	proline dehydrogenase activity
HW576_25870	COG4897	Protein conserved in bacteria
HW576_25875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW576_25880	COG0793	Belongs to the peptidase S41A family
HW576_25880	COG3409	Peptidoglycan-binding domain 1 protein
HW576_25885	COG0739	heme binding
HW576_25890	COG2177	Part of the ABC transporter FtsEX involved in
HW576_25895	COG2884	Cell division ATP-binding protein ftsE
HW576_25900	COG0655	NAD(P)H dehydrogenase (quinone) activity
HW576_25910	COG0805	protein transport
HW576_25915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW576_25920	COG3540	Alkaline phosphatase
HW576_25930	COG0653	protein targeting
HW576_25935	COG0456	acetyltransferase
HW576_25940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HW576_25950	COG1516	flagellar protein fliS
HW576_25955	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HW576_25965	COG1113	amino acid transport
HW576_25975	COG1012	belongs to the aldehyde dehydrogenase family
HW576_25980	COG1454	alcohol dehydrogenase
HW576_25985	COG1510	regulation of RNA biosynthetic process
HW576_25990	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HW576_25995	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HW576_26000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW576_26005	COG4786	Flagellar basal body rod
HW576_26005	COG1256	bacterial-type flagellum assembly
HW576_26025	COG1040	competence protein
HW576_26030	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HW576_26035	COG1307	EDD domain protein, DegV family
HW576_26040	COG1728	Protein conserved in bacteria
HW576_26050	COG2197	response regulator
HW576_26055	COG4585	Histidine kinase
HW576_26060	COG1739	Uncharacterized protein family UPF0029
HW576_26065	COG1316	TRANSCRIPTIONal
HW576_26070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW576_26075	COG1585	Membrane protein implicated in regulation of membrane protease activity
HW576_26080	COG2268	Band 7 protein
HW576_26085	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HW576_26095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW576_26105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW576_26110	COG0791	NLP P60 protein
HW576_26110	COG1388	LysM domain
HW576_26115	COG0629	single-stranded DNA binding
HW576_26135	COG4786	Flagellar basal body rod
HW576_26140	COG4786	Flagellar basal body rod
HW576_26145	COG1077	Cell shape determining protein MreB Mrl
HW576_26150	COG1609	Transcriptional regulator
HW576_26155	COG0739	heme binding
HW576_26160	COG2385	sporulation resulting in formation of a cellular spore
HW576_26175	COG4836	Membrane
HW576_26180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HW576_26185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HW576_26190	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HW576_26195	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HW576_26200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW576_26205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HW576_26210	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW576_26215	COG0356	it plays a direct role in the translocation of protons across the membrane
HW576_26230	COG1404	Belongs to the peptidase S8 family
HW576_26235	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HW576_26240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HW576_26255	COG0698	ribose 5-phosphate isomerase
HW576_26270	COG1971	Probably functions as a manganese efflux pump
HW576_26275	COG0009	L-threonylcarbamoyladenylate synthase
HW576_26295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HW576_26310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HW576_26320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW576_26325	COG0191	fructose-bisphosphate aldolase activity
HW576_26330	COG2204	response regulator
HW576_26335	COG4821	SIS domain
HW576_26340	COG0504	CTP synthase activity
HW576_26350	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW576_26350	COG1703	isobutyryl-CoA mutase activity
HW576_26350	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW576_26360	COG1960	acyl-CoA dehydrogenase activity
HW576_26365	COG1960	acyl-CoA dehydrogenase activity
HW576_26370	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW576_26375	COG0183	Belongs to the thiolase family
HW576_26380	COG0247	lactate metabolic process
HW576_26380	COG2181	nitrate reductase activity
HW576_26385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW576_26390	COG4294	response to UV
HW576_26395	COG0018	arginyl-trna synthetase
HW576_26400	COG4506	Protein conserved in bacteria
HW576_26405	COG0010	Belongs to the arginase family
HW576_26410	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW576_26415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW576_26425	COG1994	Peptidase M50
HW576_26430	COG1942	4-Oxalocrotonate Tautomerase
HW576_26435	COG3465	dGTPase activity
HW576_26440	COG1078	dGTPase activity
HW576_26445	COG4844	belongs to the
HW576_26455	COG0095	Lipoate-protein ligase
HW576_26460	COG0280	phosphate acetyltransferase
HW576_26470	COG3773	Cell wall hydrolase
HW576_26480	COG2363	Small membrane protein
HW576_26490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HW576_26500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW576_26505	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HW576_26510	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HW576_26510	COG2508	Transcriptional regulator
HW576_26515	COG0686	Belongs to the AlaDH PNT family
HW576_26525	COG0351	phosphomethylpyrimidine kinase
HW576_26530	COG0561	phosphatase activity
HW576_26535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW576_26540	COG2190	(PTS) system
HW576_26540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW576_26540	COG1263	PTS System
HW576_26550	COG0438	transferase activity, transferring glycosyl groups
HW576_26565	COG2076	Multidrug Resistance protein
HW576_26575	COG0728	peptidoglycan biosynthetic process
HW576_26590	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HW576_26595	COG4988	ABC transporter
HW576_26600	COG1294	oxidase, subunit
HW576_26605	COG1271	oxidase subunit
HW576_26610	COG3610	response to peptide
HW576_26615	COG2966	Psort location CytoplasmicMembrane, score
HW576_26620	COG1609	Transcriptional regulator
HW576_26630	COG2814	Major facilitator Superfamily
HW576_26645	COG1966	Carbon starvation protein
HW576_26650	COG0753	catalase activity
HW576_26660	COG0471	metal ion transport
HW576_26665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HW576_26675	COG0745	RESPONSE REGULATOR receiver
HW576_26680	COG5002	protein histidine kinase activity
HW576_26695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW576_26700	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HW576_26710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW576_26715	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HW576_26720	COG4853	Protein conserved in bacteria
HW576_26730	COG5002	protein histidine kinase activity
HW576_26735	COG0745	RESPONSE REGULATOR receiver
HW576_26760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HW576_26765	COG0305	Participates in initiation and elongation during chromosome replication
HW576_26775	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HW576_26785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HW576_26795	COG0360	Binds together with S18 to 16S ribosomal RNA
HW576_26800	COG0012	GTP binding
HW576_26805	COG4481	Protein conserved in bacteria
HW576_26810	COG0668	transmembrane transport
HW576_26815	COG3949	Membrane
HW576_26825	COG1475	DNA binding
HW576_26830	COG1192	Involved in chromosome partitioning
HW576_26835	COG1475	DNA binding
HW576_26845	COG0445	tRNA wobble uridine modification
HW576_26850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HW576_26855	COG1847	R3H domain protein
HW576_26860	COG0706	membrane insertase activity
HW576_26865	COG0594	ribonuclease P activity
HW576_26870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HW576_26905	COG1714	RDD family
HW576_26935	COG0693	protein deglycase activity
HW576_27005	COG1131	(ABC) transporter
HW576_27020	COG1136	(ABC) transporter
HW576_27025	COG0577	efflux transmembrane transporter activity
HW576_27035	COG5002	protein histidine kinase activity
HW576_27055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW576_27060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW576_27065	COG0667	Aldo Keto reductase
HW576_27075	COG2207	Transcriptional regulator
HW576_27080	COG1278	Cold shock
HW576_27090	COG2002	toxin-antitoxin pair type II binding
HW576_27135	COG0673	inositol 2-dehydrogenase activity
HW576_27145	COG1649	PFAM Uncharacterised BCR, COG1649
HW576_27155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW576_27160	COG1486	melibiose metabolic process
HW576_27165	COG1447	Phosphotransferase system cellobiose-specific component IIA
HW576_27175	COG2971	BadF BadG BcrA BcrD
HW576_27180	COG1737	Transcriptional regulator
HW576_27185	COG2188	Transcriptional regulator
HW576_27190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW576_27190	COG1263	PTS System
HW576_27205	COG1349	DNA-binding transcription factor activity
HW576_27210	COG0805	protein transport
HW576_27215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW576_27220	COG0402	S-adenosylhomocysteine deaminase activity
HW576_27225	COG2233	PERMEase
HW576_27235	COG1609	Transcriptional regulator
HW576_27240	COG0673	inositol 2-dehydrogenase activity
HW576_27245	COG1082	Xylose isomerase domain protein TIM barrel
HW576_27250	COG2814	Major facilitator Superfamily
HW576_27255	COG1609	Transcriptional regulator
HW576_27265	COG1175	transmembrane transport
HW576_27270	COG0395	ABC-type sugar transport system, permease component
HW576_27285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW576_27290	COG0110	maltose O-acetyltransferase activity
HW576_27300	COG2070	2-Nitropropane dioxygenase
HW576_27310	COG1733	regulation of RNA biosynthetic process
HW576_27315	COG2085	NADP oxidoreductase coenzyme F420-dependent
HW576_27320	COG3344	reverse transcriptase
HW576_27345	COG0672	)-iron permease
HW576_27365	COG2890	protein-(glutamine-N5) methyltransferase activity
HW576_27375	COG0789	Transcriptional regulator
HW576_27380	COG2223	nitrite transmembrane transporter activity
HW576_27390	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW576_27395	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW576_27405	COG0697	spore germination
HW576_27425	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HW576_27435	COG1027	Aspartate ammonia-lyase
HW576_27460	COG1994	Peptidase M50
HW576_27485	COG0697	spore germination
HW576_27495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW576_27500	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW576_27505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW576_27510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW576_27515	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_27525	COG0531	amino acid
HW576_27530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW576_27555	COG1051	belongs to the nudix hydrolase family
HW576_27560	COG1846	Transcriptional regulator
HW576_27570	COG1027	Aspartate ammonia-lyase
HW576_27580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW576_27585	COG5002	protein histidine kinase activity
HW576_27590	COG0745	RESPONSE REGULATOR receiver
HW576_27595	COG2351	hydroxyisourate hydrolase activity
HW576_27665	COG2002	toxin-antitoxin pair type II binding
HW576_27720	COG2207	Transcriptional regulator
HW576_27730	COG1228	amidohydrolase
HW576_27735	COG0010	Belongs to the arginase family
HW576_27740	COG2271	Major facilitator Superfamily
HW576_27745	COG0477	Major facilitator Superfamily
HW576_27750	COG2986	histidine ammonia-lyase
HW576_27770	COG3773	Cell wall hydrolase
HW576_27780	COG1396	sequence-specific DNA binding
HW576_27810	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_27825	COG1733	regulation of RNA biosynthetic process
HW576_27835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW576_27845	COG3773	Cell wall hydrolase
HW576_27850	COG2261	transglycosylase associated protein
HW576_27855	COG1994	Peptidase M50
HW576_27890	COG0252	asparaginase activity
HW576_27900	COG1027	Aspartate ammonia-lyase
HW576_27915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW576_27950	COG3764	Sortase (surface protein transpeptidase)
HW576_27955	COG0531	amino acid
HW576_27960	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HW576_27965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW576_27980	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HW576_28015	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW576_28030	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW576_28035	COG2814	Major facilitator Superfamily
HW576_28040	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HW576_28050	COG2814	Major facilitator Superfamily
HW576_28055	COG0626	cystathionine gamma-synthase activity
HW576_28060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW576_28070	COG0656	L-ascorbic acid biosynthetic process
HW576_28100	COG0822	iron-sulfur transferase activity
HW576_28115	COG2072	flavoprotein involved in K transport
HW576_28120	COG0318	PFAM AMP-dependent synthetase and ligase
HW576_28155	COG0531	amino acid
HW576_28165	COG1114	Component of the transport system for branched-chain amino acids
HW576_28180	COG0531	amino acid
HW576_28255	COG0513	Belongs to the DEAD box helicase family
HW576_28265	COG1278	Cold shock
HW576_28270	COG3239	Fatty acid desaturase
HW576_28280	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_28285	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_28320	COG2095	MarC family integral membrane protein
HW576_28325	COG0604	alcohol dehydrogenase
HW576_28325	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_28325	COG3321	synthase
HW576_28355	COG3238	Protein conserved in bacteria
HW576_28360	COG0477	Major facilitator Superfamily
HW576_28385	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW576_28390	COG1733	regulation of RNA biosynthetic process
HW576_28395	COG5553	Cysteine dioxygenase type I
HW576_28400	COG0697	spore germination
HW576_28405	COG2318	DinB family
HW576_28490	COG1086	Polysaccharide biosynthesis protein
HW576_28515	COG0438	transferase activity, transferring glycosyl groups
HW576_28525	COG1216	Glycosyl transferase, family 2
HW576_28540	COG1216	Glycosyl transferase, family 2
HW576_28610	COG0515	serine threonine protein kinase
HW576_28645	COG0277	FAD linked oxidase domain protein
HW576_28760	COG2132	Multicopper oxidase
HW576_28795	COG0726	polysaccharide deacetylase
HW576_28840	COG2226	methyltransferase
HW576_28885	COG0189	ligase activity
HW576_28900	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW576_28930	COG3679	Belongs to the UPF0342 family
HW576_29070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW576_29125	COG0024	Methionine aminopeptidase
HW576_29140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW576_29150	COG1131	(ABC) transporter
HW576_29160	COG0494	nUDIX hydrolase
HW576_29175	COG5002	protein histidine kinase activity
HW576_29185	COG0577	efflux transmembrane transporter activity
HW576_29185	COG1136	(ABC) transporter
HW576_29245	COG0604	alcohol dehydrogenase
HW576_29255	COG0662	Cupin 2, conserved barrel domain protein
HW576_29260	COG1278	Cold shock
HW576_29345	COG5444	nuclease activity
HW576_29355	COG0697	spore germination
HW576_29360	COG0583	DNA-binding transcription factor activity
HW576_29370	COG2267	carboxylic ester hydrolase activity
HW576_29375	COG2318	DinB family
HW576_29385	COG1694	Mazg nucleotide pyrophosphohydrolase
HW576_29390	COG0456	acetyltransferase
HW576_29430	COG2030	dehydratase
HW576_29435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW576_29440	COG0300	oxidoreductase activity
HW576_29450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HW576_29475	COG1733	regulation of RNA biosynthetic process
HW576_29480	COG1309	transcriptional regulator
HW576_29485	COG1902	pentaerythritol trinitrate reductase activity
HW576_29495	COG0561	phosphatase activity
HW576_29625	COG1278	Cold shock
HW576_29735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW576_29805	COG2002	toxin-antitoxin pair type II binding
HW576_29815	COG1366	Belongs to the anti-sigma-factor antagonist family
HW576_29820	COG3239	Fatty acid desaturase
HW576_29830	COG1278	Cold shock
HW576_29840	COG0513	Belongs to the DEAD box helicase family
HW576_29845	COG1278	Cold shock
HW576_29865	COG0628	permease
HW576_29870	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HW576_29875	COG3729	General stress protein
HW576_29895	COG1027	Aspartate ammonia-lyase
HW576_29905	COG0583	DNA-binding transcription factor activity
HW576_29910	COG1794	racemase activity, acting on amino acids and derivatives
HW576_29915	COG2146	nitrite reductase [NAD(P)H] activity
HW576_29930	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_29940	COG4221	oxidoreductase activity
HW576_29945	COG1309	transcriptional regulator
HW576_29950	COG2723	6-phospho-beta-galactosidase activity
HW576_29955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW576_29955	COG1263	PTS System
HW576_29955	COG2190	(PTS) system
HW576_29960	COG3711	transcriptional antiterminator
HW576_29965	COG1309	transcriptional regulator
HW576_29975	COG0702	epimerase
HW576_30005	COG0702	epimerase
HW576_30010	COG1309	transcriptional regulator
HW576_30015	COG1064	alcohol dehydrogenase
HW576_30020	COG0656	L-ascorbic acid biosynthetic process
HW576_30025	COG1028	Short-chain dehydrogenase reductase Sdr
HW576_30040	COG0789	Transcriptional regulator
HW576_30045	COG1376	ErfK ybiS ycfS ynhG family protein
HW576_30110	COG0791	NLP P60 protein
HW576_30110	COG0741	lytic transglycosylase activity
HW576_30140	COG3505	Type IV secretory pathway VirD4
HW576_30190	COG3852	Histidine kinase
HW576_30195	COG0546	phosphoglycolate phosphatase activity
HW576_30205	COG0546	phosphoglycolate phosphatase activity
HW576_30210	COG2205	protein histidine kinase activity
HW576_30290	COG0741	lytic transglycosylase activity
HW576_30290	COG0791	NLP P60 protein
HW576_30355	COG1376	ErfK ybiS ycfS ynhG family protein
HW576_30365	COG1902	pentaerythritol trinitrate reductase activity
HW576_30370	COG0789	Transcriptional regulator
HW576_30405	COG1595	DNA-templated transcription, initiation
HW576_30495	COG2076	Multidrug Resistance protein
HW576_30505	COG0463	Glycosyl transferase, family 2
HW576_30620	COG3773	Cell wall hydrolase
HW576_30650	COG2217	Heavy metal translocating P-type atpase
HW576_30670	COG0701	Predicted permease
HW576_30680	COG0701	Predicted permease
HW576_30685	COG3689	TIGRFAM TIGR03943 family protein
HW576_30690	COG0772	Belongs to the SEDS family
HW576_30700	COG0598	Magnesium transport protein CorA
HW576_30705	COG0531	amino acid