locus-tag class description BMD_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BMD_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BMD_0003 ENOG410848D S4 domain protein YaaA BMD_0005 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BMD_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BMD_0013 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BMD_0015 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BMD_0016 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BMD_0019 ENOG4105ZMH deoxynucleoside kinase BMD_0021 ENOG4105VRS hydrolase family 18 BMD_0022 ENOG4105GTG Isochorismatase BMD_0023 ENOG4108Z6B deaminase BMD_0024 ENOG4105C6E dna polymerase iii BMD_0025 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BMD_0026 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BMD_0028 ENOG41067KS pro-sigma K processing BMD_0045 ENOG4105CXN decarboxylase BMD_0046 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BMD_0047 ENOG4105X0R protein from nitrogen regulatory protein P-II BMD_0048 ENOG4105FA2 dna polymerase iii BMD_0049 ENOG4105MA4 psp1 domain protein BMD_0050 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) BMD_0051 ENOG41060K3 Methyltransferase BMD_0052 ENOG4105VC4 domain protein BMD_0053 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BMD_0054 ENOG4105KRN Transcriptional regulator, abrb family BMD_0055 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BMD_0056 ENOG4105F8V Hydrolase, tatD family BMD_0057 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BMD_0058 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BMD_0059 ENOG4105XFA sporulation peptidase YabG BMD_0061 ENOG4105W42 Veg protein BMD_0064 ENOG4105DFT pur operon repressor BMD_0065 ENOG4105KME endoribonuclease L-psp BMD_0066 ENOG4105K4W Could be involved in septation (By similarity) BMD_0067 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BMD_0068 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BMD_0069 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BMD_0070 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BMD_0072 ENOG4108JA2 transcriptioN-repair coupling factor BMD_0074 ENOG4108M14 stage v sporulation protein t BMD_0076 ENOG4108IY2 MazG family BMD_0077 ENOG41082I2 s4 domain protein BMD_0078 ENOG4105VYY sporulation protein yabp BMD_0081 ENOG41060GV RNA binding s1 domain protein BMD_0084 ENOG4105G3A stage ii sporulation protein e BMD_0087 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BMD_0088 ENOG4108UGV hypoxanthine phosphoribosyltransferase BMD_0089 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BMD_0090 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BMD_0091 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BMD_0092 ENOG4105C6T cysteine synthase BMD_0093 ENOG4105CRQ synthase (Component I) BMD_0094 ENOG4105DDQ anthranilate synthase BMD_0095 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BMD_0096 ENOG4105KRF dihydroneopterin aldolase BMD_0097 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BMD_0098 ENOG4105CRK lysyL-tRNA synthetase BMD_0103 ENOG4108Z0C Uvrb UvrC protein BMD_0104 ENOG41066A3 ATP guanido phosphotransferase BMD_0106 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BMD_0107 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BMD_0108 ENOG4105CTP PilT protein domain protein BMD_0109 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BMD_0110 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BMD_0111 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BMD_0112 ENOG4105D7W serine acetyltransferase BMD_0113 ENOG4105C8N cysteinyl-tRNA synthetase BMD_0115 ENOG4105C2N RNA methyltransferase TrmH family group 3 BMD_0116 ENOG4105M0M Tetracycline resistance protein BMD_0117 ENOG4105QIV RNA polymerase BMD_0118 ENOG41087NY 50S ribosomal protein L33 BMD_0120 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BMD_0122 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BMD_0123 ENOG4108VZM 50s ribosomal protein L10 BMD_0124 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BMD_0125 ENOG4107Y49 methyltransferase BMD_0126 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BMD_0127 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BMD_0128 ENOG4105XPM ribosomal protein BMD_0129 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BMD_0130 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BMD_0132 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BMD_0134 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BMD_0135 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BMD_0136 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BMD_0137 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BMD_0138 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BMD_0139 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BMD_0140 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BMD_0141 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BMD_0142 ENOG41082SA 50s ribosomal protein l29 BMD_0143 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BMD_0144 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BMD_0147 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BMD_0148 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BMD_0149 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BMD_0151 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BMD_0152 ENOG4105VPB 50S ribosomal protein L30 BMD_0153 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BMD_0154 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BMD_0155 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BMD_0156 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BMD_0157 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BMD_0158 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BMD_0160 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BMD_0161 ENOG4108ZT0 50S ribosomal protein l17 BMD_0162 ENOG4108JJB ABC transporter BMD_0163 ENOG4108JJB ABC transporter BMD_0164 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BMD_0165 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BMD_0166 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BMD_0170 ENOG4105D1F ATP-binding protein BMD_0171 ENOG4108KSA LysR family transcriptional regulator BMD_0174 ENOG4108NMV polysaccharide deacetylase BMD_0187 ENOG4105EMN RNA polymerase sigma factor BMD_0189 ENOG4105C8B TIGR00159 family BMD_0191 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BMD_0192 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BMD_0195 ENOG4105K4H Nlp p60 protein BMD_0196 ENOG4105CTS PTS system mannitol-specific BMD_0197 ENOG4105ETD TRANSCRIPTIONal BMD_0198 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BMD_0200 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BMD_0201 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BMD_0202 ENOG4107T7U Sulfatase BMD_0205 ENOG4105F38 ABC transporter, permease BMD_0206 ENOG4105D38 putrescine abc transporter BMD_0207 ENOG4107RUE extracellular solute-binding protein family 1 BMD_0209 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMD_0210 ENOG4105US7 Histidine kinase BMD_0213 ENOG4105CPF Cell wall formation (By similarity) BMD_0214 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BMD_0215 ENOG4105C1J atp-dependent rna helicase BMD_0218 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BMD_0219 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BMD_0220 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BMD_0222 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BMD_0223 ENOG4107MMM Anti-sigma-factor antagonist BMD_0224 ENOG4105FUA antagonist BMD_0225 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BMD_0226 ENOG4107SGM protein serine threonine phosphatase BMD_0227 ENOG4105WN5 stage II sporulation protein BMD_0230 ENOG41064BQ Phosphatase BMD_0250 ENOG4105K8N protein family UPF0079, ATPase BMD_0251 ENOG41072GX Peptidase M22 Glycoprotease BMD_0252 ENOG410801F ribosomal-protein-alanine acetyltransferase BMD_0253 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BMD_0254 ENOG4105C5H ABC transporter BMD_0255 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BMD_0256 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BMD_0257 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BMD_0259 ENOG4108TYN CAAX amino terminal protease family protein BMD_0260 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BMD_0261 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BMD_0262 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BMD_0265 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BMD_0266 ENOG4105C7N Xanthine uracil vitamin C permease BMD_0271 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BMD_0272 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BMD_0273 ENOG4105C83 adenylosuccinate lyase BMD_0274 ENOG4105C8V SAICAR synthetase BMD_0275 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BMD_0276 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BMD_0277 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BMD_0279 ENOG4105CXB phosphoribosylaminoimidazole synthetase BMD_0280 ENOG4108V3E phosphoribosylglycinamide formyltransferase BMD_0281 ENOG4105DC1 bifunctional purine biosynthesis protein purh BMD_0282 ENOG4105C12 Phosphoribosylglycinamide synthetase BMD_0285 ENOG4105KGF protein, YerC YecD BMD_0286 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BMD_0288 ENOG4105C4R Atp-dependent dna helicase BMD_0289 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BMD_0292 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BMD_0293 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BMD_0294 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BMD_0295 ENOG4105CBD Diacylglycerol kinase BMD_0299 ENOG4107AYK membrAne BMD_0302 ENOG4107RMD Basic membrane lipoprotein BMD_0303 ENOG4105BZU Histidine kinase BMD_0304 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BMD_0305 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BMD_0306 ENOG4107QWG 2-Nitropropane dioxygenase BMD_0307 ENOG4108Z5V transcriptional regulator, merr family BMD_0308 ENOG4105C2C drug resistance transporter, Bcr CflA BMD_0311 ENOG4105CDA abc transporter atp-binding protein BMD_0312 ENOG4105CT1 (ABC) transporter BMD_0313 ENOG4105EAD ABC transporter BMD_0314 ENOG4105DRP amino acid AbC transporter BMD_0316 ENOG4106BRA Membrane BMD_0319 ENOG41062D9 Histidine kinase BMD_0320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMD_0322 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BMD_0326 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BMD_0327 ENOG4108ZHJ Organic hydroperoxide resistance protein BMD_0331 ENOG4107R7Y intracellular protease Pfpi family BMD_0333 ENOG4106DF1 BMD_0335 ENOG4105BZG amino acid carrier protein BMD_0339 ENOG4105D7N magnesium and cobalt transport protein CorA BMD_0341 ENOG4108MRH transcriptional regulatory protein BMD_0344 ENOG4105BZU Histidine kinase BMD_0345 ENOG4105FDU atp-dependent rna helicase BMD_0347 ENOG4108IBT Inherit from COG: transposase BMD_0356 ENOG4108K8S endonuclease I BMD_0358 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BMD_0361 ENOG4105C5H ABC transporter BMD_0362 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase BMD_0365 ENOG4105KPV Transcriptional regulator BMD_0366 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BMD_0367 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) BMD_0368 ENOG4108Z0Z intracellular protease Pfpi family BMD_0369 ENOG4105K4I Scp-like extracellular BMD_0370 ENOG4105CPN adenine deaminase BMD_0372 ENOG4105KJF protein tyrosine phosphatase BMD_0374 ENOG4107U9T Pfam:Ribonuclease_BN BMD_0375 ENOG4105C59 p-type ATPase BMD_0377 ENOG4105KTU Transcriptional regulator, arsr family BMD_0378 ENOG4105PGM cation diffusion facilitator family transporter BMD_0379 ENOG4108ISG Major Facilitator BMD_0380 ENOG4105PY6 Phenolic acid decarboxylase BMD_0382 ENOG410606W general stress protein BMD_0383 ENOG4105UPD Calcium Proton BMD_0389 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BMD_0391 ENOG4105C85 amino acid BMD_0392 ENOG4105BZU Histidine kinase BMD_0396 ENOG4105ECP epimerase BMD_0398 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr BMD_0400 ENOG4105XHU Acid-soluble spore protein K BMD_0402 ENOG41067AE Membrane-bound metal-dependent hydrolase BMD_0403 ENOG4105CEN a g-specific adenine glycosylase BMD_0404 ENOG4106BXE BMD_0405 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BMD_0408 ENOG4105EVI UPF0374 protein BMD_0409 ENOG4105BZ1 (ABC) transporter BMD_0410 ENOG4107NBY Membrane BMD_0411 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BMD_0412 ENOG4108IUW ABC transporter BMD_0416 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BMD_0417 ENOG4105G5W regulator Fur family BMD_0418 ENOG4105TUA UPF0295 protein BMD_0441 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BMD_0443 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BMD_0444 ENOG4105CYN Serine protein kinase BMD_0445 ENOG4106AKX UPF0229 protein BMD_0448 ENOG41076HS cation diffusion facilitator family transporter BMD_0450 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BMD_0452 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BMD_0454 ENOG4108REF Sporulation integral membrane protein ytvi BMD_0455 ENOG4107T5V SNARE associated Golgi BMD_0456 ENOG4105EU9 BMD_0457 ENOG4105CUB amino acid BMD_0461 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BMD_0462 ENOG4108IJ9 (ABC) transporter BMD_0463 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component BMD_0466 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BMD_0469 ENOG4105DTQ mandelate racemase muconate lactonizing BMD_0478 ENOG41069ER domain protein BMD_0479 ENOG4108VXD carboxy-peptidase BMD_0483 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BMD_0484 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BMD_0487 ENOG4105YWU small acid-soluble spore protein BMD_0489 ENOG4105ETE Transcriptional regulator (LacI family BMD_0490 ENOG4105IE8 Alpha-ketoglutarate permease BMD_0491 ENOG4105CK5 oxidoreductase BMD_0496 ENOG4105ETE Transcriptional regulator (LacI family BMD_0500 ENOG4108JYZ YitT family BMD_0505 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_0506 ENOG4105J7D transcriptional regulator BMD_0507 ENOG4105FE9 pseudouridine synthase BMD_0510 ENOG41090U3 tautomerase BMD_0511 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BMD_0514 ENOG4105D4T Citrate transporter BMD_0517 ENOG4108RE7 deoxyribonuclease BMD_0522 ENOG4105CB2 alcohol dehydrogenase BMD_0523 ENOG4105DAA L-lactate BMD_0524 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BMD_0526 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BMD_0527 ENOG4108YBP pseudouridine synthase BMD_0529 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BMD_0530 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BMD_0531 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BMD_0532 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BMD_0534 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BMD_0535 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BMD_0540 ENOG4105ED1 spovr family BMD_0542 ENOG4108Z40 Transcriptional regulator BMD_0545 ENOG4105CDA abc transporter atp-binding protein BMD_0546 ENOG4105DRP amino acid AbC transporter BMD_0551 ENOG4108VEU Thiamine monophosphate synthase BMD_0552 ENOG41080HI glycine oxidase BMD_0555 ENOG4105D06 uba thif-type nad fad binding protein BMD_0556 ENOG4105DWF phosphomethylpyrimidine kinase BMD_0561 ENOG4105YWU small acid-soluble spore protein BMD_0567 ENOG410839P BMD_0570 ENOG4105WZB UPF0342 protein BMD_0573 ENOG4105D4P Coproporphyrinogen iii oxidase BMD_0574 ENOG4105CEY Amp-dependent synthetase and ligase BMD_0575 ENOG4105CGU Enoyl-CoA hydratase BMD_0576 ENOG4105K70 DNA-binding protein BMD_0578 ENOG4108IUX (ABC) transporter BMD_0579 ENOG4105RHA ABC transporter, permease BMD_0580 ENOG4105EQI Metal Dependent Phosphohydrolase BMD_0582 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BMD_0585 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) BMD_0587 ENOG4105NBU tryptophan transport protein BMD_0588 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BMD_0589 ENOG4105U3E Transcriptional regulator BMD_0590 ENOG4107YB6 acetyltransferase, (GNAT) family BMD_0591 ENOG4105EXC Acyl-transferase BMD_0592 ENOG4105K59 histidine triad (HIT) protein BMD_0597 ENOG410841Q phosphoesterase PA-phosphatase related protein BMD_0599 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BMD_0600 ENOG4105BZ4 penicillin-binding protein BMD_0601 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BMD_0602 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BMD_0603 ENOG4105C1Q protoporphyrinogen oxidase BMD_0605 ENOG4107RF6 penicillin-binding protein BMD_0607 ENOG4105C2F Histidine kinase BMD_0610 ENOG4108RQ5 Beta-lactamase domain-containing protein BMD_0611 ENOG4105DF9 Lipoate-protein, ligase BMD_0612 ENOG4105CEY Amp-dependent synthetase and ligase BMD_0613 ENOG4105E39 Enoyl-CoA hydratase BMD_0636 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BMD_0639 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BMD_0641 ENOG4105CHR reductase BMD_0643 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BMD_0645 ENOG4105EYH Exonuclease BMD_0656 ENOG4105CAQ asparagine synthetase BMD_0659 ENOG4105FE1 phytoene synthase BMD_0660 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BMD_0661 ENOG4105FKQ transcriptional regulator BMD_0662 ENOG4105C26 Dehydrogenase BMD_0663 ENOG4105C8Y Acetylornithine aminotransferase BMD_0666 ENOG4108JUB Transcriptional regulator BMD_0667 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BMD_0668 ENOG4108VPT UPF0234 protein BMD_0669 ENOG4105QNR S1 RNA binding domain protein BMD_0671 ENOG4105EPR degv family BMD_0672 ENOG4107AYK membrAne BMD_0675 ENOG4108KP7 hydrolase BMD_0676 ENOG4105VG1 fes assembly suf system protein BMD_0677 ENOG4107V6Q Cyclic nucleotide-binding domain BMD_0678 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BMD_0679 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BMD_0680 ENOG4105CAS nag kinase BMD_0684 ENOG4105DBV ornithine carbamoyltransferase BMD_0687 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BMD_0689 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BMD_0690 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BMD_0691 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BMD_0696 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BMD_0697 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BMD_0699 ENOG4105C3U ABC transporter BMD_0700 ENOG4108JQ7 (ABC) transporter BMD_0704 ENOG4108KU1 UPF0736 protein BMD_0705 ENOG4105C31 Tryptophanyl-tRNA synthetase BMD_0706 ENOG4108J59 Extracellular solute-binding protein, family 5 BMD_0707 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BMD_0708 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BMD_0710 ENOG4108JQ7 (ABC) transporter BMD_0712 ENOG4105C85 amino acid BMD_0713 ENOG4105D5Q Arginine ornithine antiporter BMD_0714 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BMD_0715 ENOG4107RSM transcriptional regulator BMD_0718 ENOG4108ZCF integral membrane protein BMD_0720 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BMD_0722 ENOG4105DPN Oligoendopeptidase f BMD_0724 ENOG4105T58 Dithiol-disulfide isomerase BMD_0725 ENOG4108Z18 K06886 hemoglobin BMD_0726 ENOG4105E4C Lytic transglycosylase catalytic BMD_0727 ENOG4105MIX Adenylate cyclase BMD_0730 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BMD_0731 ENOG4105EMS pseudouridine synthase BMD_0732 ENOG4107S1Q Phosphatase BMD_0733 ENOG4105CJW magnesium transporter BMD_0743 ENOG4105ENA helicase BMD_0745 ENOG4105H67 Protein of unknown function (DUF421) BMD_0747 ENOG4108ZMI UPF0477 protein BMD_0752 ENOG4106KNT transcriptional regulator BMD_0754 ENOG4105CMG Carbohydrate kinase BMD_0755 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BMD_0756 ENOG4105C6Z Gluconate BMD_0760 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BMD_0761 ENOG4107ZXU DSBA oxidoreductase BMD_0763 ENOG4105C1J atp-dependent rna helicase BMD_0764 ENOG4106N3A copper homeostasis protein cutc BMD_0765 ENOG4105C85 amino acid BMD_0767 ENOG4108W8B Beta-lactamase domain protein BMD_0769 ENOG4105EMD TRANSCRIPTIONal BMD_0770 ENOG4105VZJ PTS System BMD_0771 ENOG4105CK1 PTS System BMD_0772 ENOG4105VCP PTS System BMD_0773 ENOG4105F8D glycoside hydrolase family 4 BMD_0774 ENOG4108HRK Histidine kinase BMD_0775 ENOG4105DY9 regulatoR BMD_0777 ENOG41067MG lrgb family BMD_0778 ENOG4108IFG nitrite reductase, (NAD(P)H) BMD_0779 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BMD_0781 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BMD_0784 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BMD_0787 ENOG4107STF Involved in phosphonate degradation (By similarity) BMD_0789 ENOG4107FQX Alpha-acetolactate decarboxylase BMD_0793 ENOG4105KVH Transcriptional regulator BMD_0794 ENOG4105F27 Major Facilitator BMD_0795 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BMD_0799 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) BMD_0804 ENOG4105CSV Glutaminase BMD_0806 ENOG4105E1V na solute symporter BMD_0808 ENOG4105Q95 Cupin 2, conserved barrel domain protein BMD_0809 ENOG4107QTZ amino acid BMD_0811 ENOG4108S4H thioesterase Superfamily protein BMD_0812 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BMD_0815 ENOG4105C4B ABC transporter, permease BMD_0816 ENOG4108IXI (ABC) transporter BMD_0819 ENOG4107X8C Efflux transporter RND family MFP subunit BMD_0820 ENOG4105C19 ABC transporter BMD_0821 ENOG4107RBB ABC transporter, permease BMD_0823 ENOG4105EEI dihydropteroate synthase BMD_0827 ENOG4108IQI permease BMD_0829 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BMD_0830 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BMD_0832 ENOG4108ZCF integral membrane protein BMD_0833 ENOG4105CK2 sodium dicarboxylate symporter BMD_0834 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BMD_0835 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BMD_0836 ENOG4108MRH transcriptional regulatory protein BMD_0837 ENOG4105CSC Glucose uptake protein BMD_0838 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BMD_0842 ENOG4107D63 BMD_0843 ENOG4105VZ8 Transcriptional regulator BMD_0845 ENOG4105E0M Sulfatase BMD_0848 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BMD_0849 ENOG4108J5H Homocysteine s-methyltransferase BMD_0850 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BMD_0852 ENOG4105D4T Citrate transporter BMD_0854 ENOG4108MRH transcriptional regulatory protein BMD_0856 ENOG4108KAM Transcriptional regulator BMD_0857 ENOG4108KK1 membrane protein AbrB duplication BMD_0858 ENOG41089UC methyltransferase, type 11 BMD_0859 ENOG4107SQ8 Glycine betaine BMD_0860 ENOG4108IJ7 Glycine betaine BMD_0863 ENOG4105C26 Dehydrogenase BMD_0864 ENOG4105C8Y Acetylornithine aminotransferase BMD_0866 ENOG4105CUB amino acid BMD_0867 ENOG4107YBY Hydrolase BMD_0869 ENOG4107T8P acyl-Coa dehydrogenase BMD_0870 ENOG4105FBW Monooxygenase BMD_0871 ENOG4107T8P acyl-Coa dehydrogenase BMD_0872 ENOG4108HUF Transporter BMD_0873 ENOG4105DQ5 transport system permease protein BMD_0874 ENOG4108U1V ABC transporter, permease BMD_0880 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BMD_0885 ENOG4105ETU transcriptional activator (TenA BMD_0887 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BMD_0890 ENOG41080HJ 6-phospho 3-hexuloisomerase BMD_0891 ENOG4108VA3 3-hexulose-6-phosphate synthase BMD_0892 ENOG4105KVH Transcriptional regulator BMD_0899 ENOG4105ECB domain protein BMD_0900 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BMD_0901 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMD_0902 ENOG4105KVH Transcriptional regulator BMD_0905 ENOG4105BZ1 (ABC) transporter BMD_0906 ENOG4105BZ1 (ABC) transporter BMD_0910 ENOG4105MI2 BMD_0911 ENOG4107HP6 Transcriptional regulator BMD_0913 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BMD_0915 ENOG41067TZ transcriptional regulator, MarR family BMD_0916 ENOG4105CW7 secretion protein, HlyD family BMD_0917 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_0918 ENOG4105CS1 NAD(P)H quinone oxidoreductase BMD_0921 ENOG4105ETE Transcriptional regulator (LacI family BMD_0922 ENOG4108RVA ribokinase BMD_0923 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BMD_0924 ENOG4105C2J ABC transporter BMD_0925 ENOG4105CNN ABC, transporter BMD_0926 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BMD_0927 ENOG41069ER domain protein BMD_0928 ENOG4107XC4 flavin reductase domain protein, FMN-binding BMD_0935 ENOG4105BZU Histidine kinase BMD_0937 ENOG4107QJZ Glycosyl transferase, family 2 BMD_0940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMD_0941 ENOG4105BZU Histidine kinase BMD_0943 ENOG4106HB6 Alpha beta hydrolase BMD_0945 ENOG4108JPW Aminotransferase BMD_0948 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BMD_0949 ENOG4105C7N Xanthine uracil vitamin C permease BMD_0951 ENOG4105ETE Transcriptional regulator (LacI family BMD_0952 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BMD_0955 ENOG4105FF2 Type I DHQase BMD_0957 ENOG4105C5Y PTS System BMD_0958 ENOG4105CG3 alpha amylase, catalytic region BMD_0959 ENOG4107414 GntR family transcriptional regulator BMD_0960 ENOG4105P4J Allophanate hydrolase, subunit 1 BMD_0962 ENOG4105E7W lamb ycsf family protein BMD_0963 ENOG4105C5A transporter BMD_0964 ENOG4108UT2 hemolysin iii BMD_0969 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase BMD_0970 ENOG4106F5Q Membrane BMD_0973 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BMD_0975 ENOG4105E2X shikimate dehydrogenase BMD_0977 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BMD_0978 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BMD_0982 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BMD_0985 ENOG4105CUB amino acid BMD_0986 ENOG4105DZC cytosine deaminase BMD_0987 ENOG4105VEQ Cold shock protein BMD_0988 ENOG4108RYK Nad-dependent epimerase dehydratase BMD_0989 ENOG4105EE0 oxidoreductase BMD_0990 ENOG4105D3R alkyl hydroperoxide reductase BMD_0991 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BMD_0997 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BMD_0998 ENOG4105KPY Small multidrug resistance protein BMD_0999 ENOG4105KPY Small multidrug resistance protein BMD_1015 ENOG4105F32 YngK protein BMD_1016 ENOG4106KNT transcriptional regulator BMD_1020 ENOG4105F8D glycoside hydrolase family 4 BMD_1022 ENOG4105VCP PTS System BMD_1024 ENOG4105RD7 BadF BadG BcrA BcrD BMD_1025 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BMD_1026 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BMD_1027 ENOG4106ETB IIa component BMD_1029 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC BMD_1030 ENOG4105C4K Nad synthetase BMD_1032 ENOG4105E66 phosphoriboisomerase A BMD_1035 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BMD_1037 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BMD_1038 ENOG4108WAV Transcriptional regulator BMD_1041 ENOG4105CPC Aldo Keto reductase BMD_1044 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BMD_1046 ENOG4105CMR udp-glucose 4-epimerase BMD_1050 ENOG4108M8H domain protein BMD_1051 ENOG4105BZU Histidine kinase BMD_1052 ENOG4105KVH Transcriptional regulator BMD_1053 ENOG4105CSC Glucose uptake protein BMD_1054 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BMD_1055 ENOG4105C09 Bile acid BMD_1056 ENOG4106CAD Protein of unknown function (DUF3311) BMD_1057 ENOG4105E1V na solute symporter BMD_1067 ENOG4105JFG SpoIID LytB domain protein BMD_1068 ENOG4105CV8 reductase BMD_1072 ENOG4105DTQ mandelate racemase muconate lactonizing BMD_1076 ENOG4108JPW Aminotransferase BMD_1078 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_1082 ENOG41082BM Transcriptional regulator, arsr family BMD_1088 ENOG4105BZU Histidine kinase BMD_1089 ENOG4105EUJ GTP cyclohydrolase i BMD_1090 ENOG4108JU3 Alkyl hydroperoxide reductase BMD_1094 ENOG4105PNM synthesis protein BMD_1105 ENOG4107RVV histidinol phosphate phosphatase, hisj family BMD_1110 ENOG4105BZ1 (ABC) transporter BMD_1114 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BMD_1115 ENOG4105D3Q Sugar transferase BMD_1118 ENOG4105JEU Glycosyl transferase, family 2 BMD_1120 ENOG4105CG5 Glycosyl transferase (Group 1 BMD_1122 ENOG4105C6Y Udp-glucose 6-dehydrogenase BMD_1123 ENOG4105HTX biosynthesis protein BMD_1124 ENOG4107YJ4 chain length determinant protein BMD_1125 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BMD_1126 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BMD_1129 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BMD_1132 ENOG4105CBC glutamate synthase BMD_1134 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BMD_1136 ENOG4105C6Z Gluconate BMD_1140 ENOG4108IFG nitrite reductase, (NAD(P)H) BMD_1141 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BMD_1142 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BMD_1143 ENOG4108QTI )-transporter BMD_1144 ENOG4105D7K pfkb domain protein BMD_1148 ENOG4107QJQ Mate efflux family protein BMD_1150 ENOG4108KGH TRANSCRIPTIONal BMD_1152 ENOG4105D7N magnesium and cobalt transport protein CorA BMD_1153 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BMD_1157 ENOG4108SU4 UPF0309 protein BMD_1158 ENOG4105FDP GntR family transcriptional regulator BMD_1159 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BMD_1160 ENOG4105CE4 GlcNAc 6-P deacetylase BMD_1161 ENOG4105CI1 PTS System BMD_1162 ENOG4108UQV Membrane BMD_1169 ENOG4105CJ1 ABC, transporter BMD_1170 ENOG4105C37 (CBS) domain BMD_1173 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BMD_1183 ENOG4108XSB acetyltransferase, (GNAT) family BMD_1184 ENOG4105CH2 amidohydrolase BMD_1190 ENOG4105RHY Pfam:UPF0157 BMD_1191 ENOG4105DP8 Major facilitator superfamily MFS_1 BMD_1193 ENOG4105C7N Xanthine uracil vitamin C permease BMD_1195 ENOG4107Y7X LytTR BMD_1196 ENOG4108IUW ABC transporter BMD_1197 ENOG4108SDH ABC, transporter BMD_1201 ENOG4105E0X reductase BMD_1202 ENOG4108B31 Spore germination protein BMD_1205 ENOG4105G6Z alkaline phosphatase BMD_1206 ENOG4105DY9 regulatoR BMD_1207 ENOG4105BZU Histidine kinase BMD_1208 ENOG4107TS3 membrane protein, TerC BMD_1209 ENOG4108WZW RNA polymerase sigma BMD_1210 ENOG410681C small acid-soluble spore protein BMD_1215 ENOG4105CHR reductase BMD_1221 ENOG4105JXH GntR family transcriptional regulator BMD_1222 ENOG4105DAP Nicotinate phosphoribosyltransferase BMD_1223 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BMD_1224 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BMD_1225 ENOG4107QR9 Iron-sulfur cluster binding protein BMD_1226 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BMD_1227 ENOG4105BZU Histidine kinase BMD_1228 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BMD_1230 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BMD_1231 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BMD_1232 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BMD_1234 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BMD_1235 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BMD_1236 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BMD_1237 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BMD_1239 ENOG4105C2J ABC transporter BMD_1240 ENOG4105CNN ABC, transporter BMD_1245 ENOG41090MY MarR family Transcriptional regulator BMD_1247 ENOG4105BZU Histidine kinase BMD_1250 ENOG4105DFD Na H antiporter BMD_1255 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BMD_1256 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BMD_1257 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BMD_1258 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BMD_1259 ENOG4105K4T epimerase BMD_1265 ENOG4105F0V Cell wall hydrolase BMD_1275 ENOG4108K88 Membrane BMD_1277 ENOG4108R6K riboflavin synthase, subunit alpha BMD_1279 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BMD_1281 ENOG4105CID antiterminator BMD_1283 ENOG4105KRI phosphocarrier protein (HPr BMD_1284 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BMD_1285 ENOG41067MG lrgb family BMD_1286 ENOG4105VAW lrga family BMD_1287 ENOG4105CMU LysR family (Transcriptional regulator BMD_1290 ENOG4105CHR reductase BMD_1292 ENOG4105CHM Aminotransferase BMD_1296 ENOG4107R88 Chemotaxis protein (CheV) BMD_1297 ENOG4105UIN BMD_1298 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BMD_1300 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BMD_1303 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BMD_1304 ENOG4105EPM Diguanylate phosphodiesterase BMD_1307 ENOG4107IN1 Protein of unknown function (DUF1797) BMD_1310 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BMD_1311 ENOG4105CH2 amidohydrolase BMD_1313 ENOG4105D8X mechanosensitive ion channel BMD_1314 ENOG4105D3R alkyl hydroperoxide reductase BMD_1315 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BMD_1317 ENOG4105BZ1 (ABC) transporter BMD_1318 ENOG4105BZ1 (ABC) transporter BMD_1319 ENOG4107ZYR domain protein BMD_1320 ENOG4105CN5 Metallo-Beta-Lactamase BMD_1321 ENOG4106EHS UPF0356 protein BMD_1322 ENOG4108X4Q Hydrolase BMD_1327 ENOG4105CPP Dehydrogenase, E1 component BMD_1328 ENOG4105C7S Dehydrogenase BMD_1331 ENOG4105C94 Transporter BMD_1333 ENOG4105CXN decarboxylase BMD_1334 ENOG4105WBI UPF0223 protein BMD_1338 ENOG4105ECY inositol monophosphatase BMD_1340 ENOG4105CI3 gtp-binding protein typa BMD_1341 ENOG4105QA2 BMD_1346 ENOG4108IAB Phoh family BMD_1349 ENOG4105CNI cell division protein FtsW BMD_1350 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BMD_1351 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BMD_1352 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BMD_1359 ENOG41080XQ Signal transduction protein with cbs domains BMD_1360 ENOG4106UY4 Inherit from COG: Scp-like extracellular BMD_1363 ENOG4108JYZ YitT family BMD_1364 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BMD_1365 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BMD_1366 ENOG4108Z5K methylglyoxal synthase BMD_1367 ENOG4105FJR Lmbe family BMD_1368 ENOG4105CPK Glycosyl transferase (Group 1 BMD_1369 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BMD_1370 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BMD_1372 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BMD_1373 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BMD_1374 ENOG4105DVT helicase BMD_1376 ENOG4105YAC BMD_1378 ENOG4105CHM Aminotransferase BMD_1381 ENOG4105CSM endonuclease III BMD_1383 ENOG4105BZ4 penicillin-binding protein BMD_1394 ENOG4106UIA BMD_1396 ENOG4105C28 cystathionine BMD_1397 ENOG4105C28 cystathionine BMD_1404 ENOG4105VEQ Cold shock protein BMD_1407 ENOG4105BZU Histidine kinase BMD_1409 ENOG4108I5C dEAD DEAH box helicase BMD_1410 ENOG4107X2U Inherit from COG: Exonuclease-like protein BMD_1412 ENOG4106F55 Protein of unknown function (DUF1273) BMD_1414 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BMD_1419 ENOG4105WH1 Two component transcriptional regulator luxr family BMD_1421 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BMD_1426 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BMD_1430 ENOG4105DVT helicase BMD_1431 ENOG4105CTD carboxy-peptidase BMD_1432 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BMD_1433 ENOG4105C2W permease BMD_1434 ENOG4105F04 LysR family Transcriptional regulator BMD_1435 ENOG4105C26 Dehydrogenase BMD_1438 ENOG41065KQ synthase BMD_1440 ENOG410890F Dynamin family BMD_1441 ENOG410756H nucleotidyltransferase BMD_1446 ENOG41081VK Ribonuclease BMD_1456 ENOG4108ME1 Peptidase M55 D-aminopeptidase BMD_1457 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BMD_1458 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BMD_1461 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BMD_1462 ENOG4107SN7 NLP P60 protein BMD_1463 ENOG4108JQ7 (ABC) transporter BMD_1466 ENOG4105KNA -acetyltransferase BMD_1467 ENOG4105BZU Histidine kinase BMD_1472 ENOG4108S01 response regulator BMD_1473 ENOG4108ZGX Histidine kinase BMD_1474 ENOG4105ECK Fatty Acid Desaturase BMD_1476 ENOG4105IIP Membrane BMD_1477 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BMD_1478 ENOG4108TM9 integral membrane protein BMD_1480 ENOG4105K4H Nlp p60 protein BMD_1481 ENOG41087PP glycosyltransferase MGT family BMD_1482 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BMD_1487 ENOG41069H0 dihydroorotase EC 3.5.2.3 BMD_1491 ENOG4105FDP GntR family transcriptional regulator BMD_1492 ENOG4105C6Z Gluconate BMD_1493 ENOG4106P19 photosystem i assembly btpa BMD_1494 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 BMD_1496 ENOG4105G6Z alkaline phosphatase BMD_1497 ENOG4107ZXU DSBA oxidoreductase BMD_1500 ENOG41067TZ transcriptional regulator, MarR family BMD_1501 ENOG4105CW7 secretion protein, HlyD family BMD_1502 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_1507 ENOG4105EHG Permease protein BMD_1508 ENOG4105DQ5 transport system permease protein BMD_1510 ENOG4105E0A ABC, transporter BMD_1511 ENOG4105CAY ferredoxin--nadp reductase BMD_1512 ENOG4105C28 cystathionine BMD_1513 ENOG4105C2C drug resistance transporter, Bcr CflA BMD_1517 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BMD_1518 ENOG4105KVH Transcriptional regulator BMD_1519 ENOG4108VA3 3-hexulose-6-phosphate synthase BMD_1521 ENOG4105F76 Sarcosine oxidase BMD_1522 ENOG4105DVW rieske (2Fe-2S) BMD_1523 ENOG4108IJ7 Glycine betaine BMD_1526 ENOG4105CA9 Pyruvate kinase BMD_1527 ENOG4105BZU Histidine kinase BMD_1528 ENOG4105BZU Histidine kinase BMD_1529 ENOG4108MJI response regulator BMD_1531 ENOG4105CUB amino acid BMD_1534 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BMD_1536 ENOG4105EDQ levansucrase EC 2.4.1.10 BMD_1537 ENOG4108HKT sucrose-6-phosphate hydrolase BMD_1538 ENOG4108UQY Iron-storage protein BMD_1539 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_1541 ENOG4105EXW epimerase dehydratase BMD_1542 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) BMD_1543 ENOG4107RGD Major Facilitator superfamily BMD_1546 ENOG4105C26 Dehydrogenase BMD_1554 ENOG4105CN5 Metallo-Beta-Lactamase BMD_1563 ENOG4105YWU small acid-soluble spore protein BMD_1564 ENOG4105ETE Transcriptional regulator (LacI family BMD_1566 ENOG4108HKT sucrose-6-phosphate hydrolase BMD_1567 ENOG4105CNG UPF0061 protein BMD_1568 ENOG4105EDQ levansucrase EC 2.4.1.10 BMD_1569 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BMD_1570 ENOG4105YHU PTS system BMD_1571 ENOG4108IQ3 PTS system BMD_1572 ENOG4105ETZ PTS System BMD_1573 ENOG4105F3R pts system mannose fructose sorbose family iid BMD_1574 ENOG4108HKT sucrose-6-phosphate hydrolase BMD_1575 ENOG4105E5Q amino acid AbC transporter BMD_1578 ENOG4105D01 (LipO)protein BMD_1579 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BMD_1580 ENOG4108UMI ABC transporter, permease BMD_1583 ENOG4107T8P acyl-Coa dehydrogenase BMD_1584 ENOG4105D01 (LipO)protein BMD_1585 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BMD_1586 ENOG4108UMI ABC transporter, permease BMD_1589 ENOG4105CPU Monooxygenase BMD_1590 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BMD_1593 ENOG4108UIN ybak prolyl-trna synthetase associated region BMD_1596 ENOG4105C84 Histidine ammonia-lyase BMD_1598 ENOG4105CI2 imidazolone-5-propionate hydrolase BMD_1599 ENOG4108903 Formimidoylglutamase BMD_1600 ENOG4105DU0 nucleoside hydrolase BMD_1601 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BMD_1603 ENOG4105DYB Isoaspartyl dipeptidase BMD_1613 ENOG4108U05 Transcriptional regulator BMD_1614 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BMD_1615 ENOG41082BM Transcriptional regulator, arsr family BMD_1621 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 BMD_1622 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BMD_1625 ENOG4105K4H Nlp p60 protein BMD_1634 ENOG4107V2S Transcriptional regulator BMD_1639 ENOG4108PSK reductase BMD_1641 ENOG41062D9 Histidine kinase BMD_1642 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMD_1643 ENOG4107ZTW SNARE associated Golgi BMD_1645 ENOG4108ZJ4 polysaccharide deacetylase BMD_1651 ENOG4105E1K spore germination protein BMD_1652 ENOG4105UPD Calcium Proton BMD_1654 ENOG4105C0A alcohol dehydrogenase BMD_1656 ENOG4105ETE Transcriptional regulator (LacI family BMD_1657 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BMD_1658 ENOG4105CY2 Citrate transporter BMD_1659 ENOG4105CHR reductase BMD_1660 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) BMD_1661 ENOG4107RT3 EamA-like transporter family BMD_1662 ENOG4105GZI Transcriptional regulator BMD_1664 ENOG4105EYF MMPL domain protein BMD_1665 ENOG4108XG4 DNA-binding transcriptional regulator BMD_1666 ENOG4107TS3 membrane protein, TerC BMD_1672 ENOG4105XDF Protein of unknown function (DUF1272) BMD_1679 ENOG4105KPY Small multidrug resistance protein BMD_1691 ENOG4106GRI small acid-soluble spore protein H BMD_1694 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BMD_1695 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BMD_1697 ENOG41080XP Cbs domain BMD_1698 ENOG4108QG2 Membrane BMD_1699 ENOG4105DJ2 Major Facilitator Superfamily BMD_1700 ENOG4107R37 Glutamate dehydrogenase BMD_1701 ENOG4105C5Q Transcriptional regulator BMD_1702 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BMD_1703 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BMD_1704 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BMD_1706 ENOG4108JQ7 (ABC) transporter BMD_1707 ENOG4107R73 Mate efflux family protein BMD_1710 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BMD_1712 ENOG4105DXI Major Facilitator superfamily BMD_1713 ENOG4105VRS hydrolase family 18 BMD_1714 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BMD_1719 ENOG4108I0C methyltransferase BMD_1720 ENOG4105KVH Transcriptional regulator BMD_1724 ENOG4108MK9 spermidine N(1)-acetyltransferase BMD_1725 ENOG4108M26 parallel beta-helix repeat protein BMD_1747 ENOG4105E1K spore germination protein BMD_1753 ENOG4107P26 BMD_1754 ENOG4108JYZ YitT family BMD_1755 ENOG4107TXC Transcriptional regulator BMD_1757 ENOG4107PBV potassium channel BMD_1758 ENOG4105C0X amino acid BMD_1759 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BMD_1761 ENOG4107KM7 Heat induced stress protein YflT BMD_1763 ENOG41062D9 Histidine kinase BMD_1764 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMD_1769 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) BMD_1770 ENOG4105C84 Histidine ammonia-lyase BMD_1772 ENOG4105CI2 imidazolone-5-propionate hydrolase BMD_1773 ENOG4108903 Formimidoylglutamase BMD_1774 ENOG4108I5G Major Facilitator superfamily BMD_1776 ENOG4107BMA Transglycosylase associated protein BMD_1778 ENOG4108IJ0 Aspartate ammonia-lyase BMD_1782 ENOG4107KM7 Heat induced stress protein YflT BMD_1784 ENOG4108RAV Conserved protein BMD_1785 ENOG4108RAV Conserved protein BMD_1788 ENOG4107KM7 Heat induced stress protein YflT BMD_1795 ENOG4106BXE BMD_1796 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BMD_1797 ENOG4105CG3 alpha amylase, catalytic region BMD_1800 ENOG41080XP Cbs domain BMD_1802 ENOG4107KM7 Heat induced stress protein YflT BMD_1808 ENOG4105KTB nuclear export factor GLE1 BMD_1810 ENOG4108PJD permease BMD_1813 ENOG4108PJD permease BMD_1817 ENOG4105C59 p-type ATPase BMD_1820 ENOG4108JYZ YitT family BMD_1826 ENOG4105CPC Aldo Keto reductase BMD_1830 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BMD_1834 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BMD_1836 ENOG4108JQ7 (ABC) transporter BMD_1838 ENOG4108Z66 YbaK ebsC protein BMD_1840 ENOG4105CSH Transporter BMD_1844 ENOG4105C26 Dehydrogenase BMD_1850 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BMD_1852 ENOG41080XP Cbs domain BMD_1856 ENOG4108IG5 Transcriptional regulator BMD_1859 ENOG4105CMG Carbohydrate kinase BMD_1860 ENOG4107QNK )-transporter BMD_1861 ENOG4105E2S oxidase) subunit II BMD_1862 ENOG4105BZ9 Cytochrome C oxidase, subunit I BMD_1863 ENOG4105CCU oxidase (Subunit III) BMD_1865 ENOG4107YZX Universal stress protein BMD_1866 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BMD_1867 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BMD_1868 ENOG4105E1J oxidoreductase BMD_1870 ENOG4105C7N Xanthine uracil vitamin C permease BMD_1871 ENOG4108J9M Transporter BMD_1872 ENOG4107RUY (E1 component), alpha subunit BMD_1874 ENOG4107QKR Dehydrogenase BMD_1876 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BMD_1878 ENOG4105C28 cystathionine BMD_1884 ENOG4105C02 permease BMD_1885 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BMD_1887 ENOG4105CT4 transporter BMD_1891 ENOG4107YZX Universal stress protein BMD_1892 ENOG4105BZU Histidine kinase BMD_1894 ENOG4105VPX protein, conserved in bacteria BMD_1895 ENOG410681U heavy metal transport detoxification protein BMD_1896 ENOG4105C59 p-type ATPase BMD_1898 ENOG41090UD (LipO)protein BMD_1905 ENOG41082YX Transcriptional regulator, arsr family BMD_1906 ENOG4107R5R arsenical pump membrane protein BMD_1908 ENOG4108VUY thioesterase Superfamily protein BMD_1909 ENOG41081VB Hydrolase BMD_1910 ENOG4108QY0 Membrane BMD_1913 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BMD_1914 ENOG4105DRR Transcriptional regulator, GntR family BMD_1915 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BMD_1916 ENOG4105CZM Major Facilitator BMD_1917 ENOG4105KVH Transcriptional regulator BMD_1918 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BMD_1919 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BMD_1924 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BMD_1926 ENOG4105X5K response regulator receiver protein BMD_1928 ENOG4105KHC sulfurtransferase BMD_1932 ENOG4108ZJ4 polysaccharide deacetylase BMD_1937 ENOG4105CVG Homoserine O-transsuccinylase BMD_1940 ENOG4108V06 Glutathione peroxidase BMD_1942 ENOG4105C5H ABC transporter BMD_1944 ENOG4108ZJ4 polysaccharide deacetylase BMD_1945 ENOG4108Y6J UPF0403 protein BMD_1946 ENOG4107YX5 Pfam:DUF548 BMD_1948 ENOG4105SZ6 Thioredoxin BMD_1949 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BMD_1951 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) BMD_1954 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BMD_1955 ENOG4105CVJ phosphoglycerate mutase BMD_1957 ENOG4108WBT adenosyltransferase BMD_1958 ENOG4105FR1 rard protein BMD_1962 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BMD_1963 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BMD_1968 ENOG4105II7 pyrroline-5-carboxylate reductase BMD_1969 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BMD_1970 ENOG4108AEY RNA polymerase sigma factor BMD_1975 ENOG4107QMU Mate efflux family protein BMD_1976 ENOG4105CHR reductase BMD_1983 ENOG4105CDW Resistance protein BMD_1987 ENOG4108ZJ4 polysaccharide deacetylase BMD_1989 ENOG4105IIU Aminopeptidase BMD_1990 ENOG4105BZU Histidine kinase BMD_1992 ENOG4107R6U sodium dicarboxylate symporter BMD_1993 ENOG4108IUM Glycogen debranching enzyme BMD_1994 ENOG4105C26 Dehydrogenase BMD_1995 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BMD_1998 ENOG4105E14 MotA TolQ exbB proton channel BMD_1999 ENOG4105ER2 Ompa motb domain protein BMD_2002 ENOG4108NA0 Uncharacterized conserved protein (COG2071) BMD_2004 ENOG4105DFD Na H antiporter BMD_2007 ENOG4108TGC Acyltransferase BMD_2008 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BMD_2009 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMD_2010 ENOG4105US7 Histidine kinase BMD_2011 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) BMD_2012 ENOG4105DUX Transporter BMD_2014 ENOG4105C6K Malic enzyme BMD_2016 ENOG410667J hydrolase BMD_2017 ENOG4105DEN Luciferase family BMD_2019 ENOG4108XSB acetyltransferase, (GNAT) family BMD_2024 ENOG4105CDA abc transporter atp-binding protein BMD_2028 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BMD_2036 ENOG4108URH decarboxylase BMD_2038 ENOG410905X membrane-flanked domain protein BMD_2039 ENOG4105CKV Membrane BMD_2041 ENOG4105D7K pfkb domain protein BMD_2042 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BMD_2043 ENOG4105K7W phage-related replication protein BMD_2047 ENOG4107SWG transcriptional regulator MERR family BMD_2052 ENOG41069DP small acid-soluble spore protein BMD_2053 ENOG4108R1P BMD_2054 ENOG4105C5Q Transcriptional regulator BMD_2055 ENOG4105CBC glutamate synthase BMD_2056 ENOG4105BZ8 glutamate synthase BMD_2060 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BMD_2062 ENOG4107RZC phospholipase d BMD_2064 ENOG41061AU MarR family Transcriptional regulator BMD_2066 ENOG41067MG lrgb family BMD_2070 ENOG4105EDW glycosyl transferase, family 39 BMD_2071 ENOG4105CKK Glycosyl transferase, family 2 BMD_2073 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BMD_2074 ENOG4105EFI regulatoR BMD_2078 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BMD_2079 ENOG4108I5D sulfate abc transporter BMD_2080 ENOG4105ECW sulfate abc transporter BMD_2083 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BMD_2086 ENOG4105E98 transcriptional regulator DeoR family BMD_2087 ENOG4105DE4 1-phosphofructokinase BMD_2088 ENOG4105DM4 PTS System BMD_2089 ENOG4105CFH Aspartokinase BMD_2091 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BMD_2092 ENOG4105EWK phytoene BMD_2094 ENOG4108W6C Dehydrogenase BMD_2095 ENOG41082YX Transcriptional regulator, arsr family BMD_2096 ENOG4105C26 Dehydrogenase BMD_2097 ENOG4105ETU transcriptional activator (TenA BMD_2100 ENOG4105C8J )-transporter BMD_2101 ENOG4105F0V Cell wall hydrolase BMD_2105 ENOG4105CK5 oxidoreductase BMD_2106 ENOG4107QP6 Xylose isomerase domain protein TIM barrel BMD_2107 ENOG4108VX5 3-methyladenine DNA glycosylase BMD_2109 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BMD_2110 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BMD_2112 ENOG4105I4A GCN5-related N-acetyltransferase BMD_2113 ENOG41062JF Transcriptional regulator BMD_2117 ENOG410606W general stress protein BMD_2123 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BMD_2124 ENOG4107T89 von Willebrand factor, type A BMD_2125 ENOG4108UZ3 Transporter BMD_2127 ENOG41075H3 AraC family transcriptional regulator BMD_2130 ENOG4108428 Inherit from COG: -acetyltransferase BMD_2131 ENOG4105DKW ABC transporter BMD_2134 ENOG4105EWU Squalene--hopene cyclase BMD_2136 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BMD_2138 ENOG4105JAB phenazine biosynthesis protein, phzf family BMD_2141 ENOG4108NGU Transcriptional regulator BMD_2142 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BMD_2143 ENOG4105CHR reductase BMD_2147 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BMD_2148 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BMD_2152 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_2154 ENOG410756H nucleotidyltransferase BMD_2156 ENOG4108IMY Transcriptional regulator BMD_2159 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BMD_2161 ENOG4105DAP Nicotinate phosphoribosyltransferase BMD_2162 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BMD_2163 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BMD_2164 ENOG41060GV RNA binding s1 domain protein BMD_2165 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BMD_2166 ENOG4105DTD Dehydrogenase BMD_2167 ENOG410855V Acylphosphatase BMD_2168 ENOG4105EU0 Major facilitator Superfamily BMD_2169 ENOG4105DEN Luciferase family BMD_2171 ENOG4105FTV AraC Family Transcriptional Regulator BMD_2172 ENOG4108RNG Permease of the drug metabolite transporter BMD_2173 ENOG4105C5H ABC transporter BMD_2175 ENOG4108Q8B Spore germination protein BMD_2177 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BMD_2178 ENOG4105CJ1 ABC, transporter BMD_2180 ENOG4107S6Z Na H antiporter BMD_2184 ENOG4105F6S Spore photoproduct lyase BMD_2189 ENOG4105C9U ATP-dependent DNA helicase RecQ BMD_2191 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BMD_2194 ENOG4105E2A Dehydrogenase BMD_2195 ENOG4107RZC phospholipase d BMD_2199 ENOG4107S6Z Na H antiporter BMD_2203 ENOG41073R8 VanW family BMD_2212 ENOG4105C9U ATP-dependent DNA helicase RecQ BMD_2215 ENOG4105C26 Dehydrogenase BMD_2219 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BMD_2222 ENOG4105KWG Pfam:DUF1696 BMD_2223 ENOG4105D94 Major Facilitator Superfamily BMD_2224 ENOG4105DUM transcriptional regulator, lysR family BMD_2225 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BMD_2226 ENOG4105DVE abc transporter atp-binding protein BMD_2228 ENOG4105EMN RNA polymerase sigma factor BMD_2231 ENOG4108ZHJ Organic hydroperoxide resistance protein BMD_2232 ENOG4105K56 Transcriptional regulator BMD_2236 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) BMD_2238 ENOG41069ER domain protein BMD_2242 ENOG4105BZU Histidine kinase BMD_2243 ENOG4105II7 pyrroline-5-carboxylate reductase BMD_2244 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BMD_2245 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BMD_2248 ENOG4105JSC dimethylmenaquinone methyltransferase BMD_2251 ENOG4107R13 MMPL domain protein BMD_2252 ENOG4107TUM Amidinotransferase BMD_2254 ENOG4107U9T Pfam:Ribonuclease_BN BMD_2267 ENOG4108UW5 maltose o-acetyltransferase BMD_2270 ENOG4106SCS STAS domain BMD_2271 ENOG4106CAD Protein of unknown function (DUF3311) BMD_2272 ENOG4105E1V na solute symporter BMD_2275 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BMD_2279 ENOG4105C9Q fumarate hydratase class II BMD_2281 ENOG4107YXZ hydrolase, family 25 BMD_2283 ENOG4105BZU Histidine kinase BMD_2289 ENOG4108RCM Nitroreductase BMD_2291 ENOG4108IXY short-chain dehydrogenase reductase BMD_2292 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BMD_2293 ENOG4108V9W transcriptional regulatory protein BMD_2294 ENOG4105D4T Citrate transporter BMD_2296 ENOG4105CY2 Citrate transporter BMD_2297 ENOG4105DTD Dehydrogenase BMD_2298 ENOG4105CIN aminoacyl-histidine dipeptidase BMD_2304 ENOG4105CMU LysR family (Transcriptional regulator BMD_2307 ENOG4105CK2 sodium dicarboxylate symporter BMD_2308 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BMD_2311 ENOG4107VFR oxidoreductase BMD_2313 ENOG4105BZU Histidine kinase BMD_2316 ENOG4105CHR reductase BMD_2317 ENOG4105CEY Amp-dependent synthetase and ligase BMD_2319 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BMD_2320 ENOG4105E39 Enoyl-CoA hydratase BMD_2323 ENOG4108N5B 2-phosphosulfolactate phosphatase BMD_2324 ENOG4105C1G acyl-Coa dehydrogenase BMD_2325 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BMD_2326 ENOG4105CGU Enoyl-CoA hydratase BMD_2327 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BMD_2328 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BMD_2331 ENOG4105D6N CoA-transferase, subunit a BMD_2332 ENOG4107QNJ CoA-transferase subunit B BMD_2333 ENOG4105CHU acetyl-coa acetyltransferase BMD_2334 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BMD_2335 ENOG4108JPW Aminotransferase BMD_2339 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BMD_2341 ENOG4108IQI permease BMD_2343 ENOG4106XGU BMD_2347 ENOG4106AXJ AraC family transcriptional regulator BMD_2348 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BMD_2349 ENOG4105CPF Cell wall formation (By similarity) BMD_2351 ENOG4108594 Permease of the drug metabolite transporter BMD_2353 ENOG4105JKW Valine--pyruvate aminotransferase BMD_2355 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BMD_2356 ENOG4105F0V Cell wall hydrolase BMD_2358 ENOG4105CBG Sulfatase BMD_2359 ENOG4105C22 threonyL-tRNA synthetase BMD_2360 ENOG4105C22 threonyL-tRNA synthetase BMD_2362 ENOG4105CUB amino acid BMD_2363 ENOG4105F27 Major Facilitator BMD_2364 ENOG41062A4 Transcriptional regulator BMD_2365 ENOG4105EYF MMPL domain protein BMD_2368 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine BMD_2369 ENOG4105XN3 extracellular solute-binding protein family 1 BMD_2370 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BMD_2371 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BMD_2372 ENOG4108KPW sugar kinase BMD_2373 ENOG4105FDP GntR family transcriptional regulator BMD_2374 ENOG4105BZU Histidine kinase BMD_2376 ENOG41082BM Transcriptional regulator, arsr family BMD_2378 ENOG4107YUH hydrolase BMD_2380 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BMD_2383 ENOG4105NX3 Membrane BMD_2385 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BMD_2386 ENOG4108JQ1 Dehydrogenase BMD_2398 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BMD_2402 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BMD_2403 ENOG4107YXZ hydrolase, family 25 BMD_2405 ENOG4107Y9U Membrane BMD_2410 ENOG4105WS7 Cation transport regulator BMD_2411 ENOG4105EUZ Beta-lactamase domain protein BMD_2413 ENOG4105D82 Glutamate dehydrogenase BMD_2429 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BMD_2432 ENOG4105P8F nudix hydrolase BMD_2435 ENOG41067TZ transcriptional regulator, MarR family BMD_2436 ENOG41073R8 VanW family BMD_2437 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BMD_2444 ENOG4105CVK Glutamate decarboxylase BMD_2450 ENOG4105TMB Formate nitrite transporter BMD_2451 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BMD_2454 ENOG4105IQ5 FAD linked oxidase domain protein BMD_2455 ENOG4105C8Q Methyl-accepting chemotaxis BMD_2458 ENOG4105DIN metallophosphoesterase BMD_2459 ENOG4108VCA G U mismatch-specific DNA glycosylase BMD_2461 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BMD_2462 ENOG4107258 Transcriptional regulator BMD_2463 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BMD_2466 ENOG4105P4J Allophanate hydrolase, subunit 1 BMD_2467 ENOG4105CFM UPF0317 protein BMD_2468 ENOG4105C5A transporter BMD_2469 ENOG4105E7W lamb ycsf family protein BMD_2470 ENOG4105CG3 alpha amylase, catalytic region BMD_2472 ENOG4108J8C transporter major facilitator family protein BMD_2478 ENOG4105DYS nad(p)h dehydrogenase (quinone) BMD_2482 ENOG4107F3J Amp-dependent synthetase and ligase BMD_2483 ENOG4107ZYJ bioY protein BMD_2485 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BMD_2489 ENOG4105WH1 Two component transcriptional regulator luxr family BMD_2490 ENOG4105BZU Histidine kinase BMD_2496 ENOG41082BV acetyltransferase BMD_2497 ENOG4105C01 Dihydroxy-acid dehydratase BMD_2498 ENOG4105E5G Alpha beta hydrolase fold BMD_2499 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BMD_2502 ENOG4105CM2 brancheD-chain amino acid aminotransferase BMD_2504 ENOG4105F6E Acyl-transferase BMD_2507 ENOG4105VT2 5-hydroxyisourate hydrolase BMD_2508 ENOG4108MK9 spermidine N(1)-acetyltransferase BMD_2511 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BMD_2513 ENOG4105U0R haloacid dehalogenase-like hydrolase BMD_2514 ENOG4105RV9 Transcriptional regulator BMD_2516 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BMD_2520 ENOG4107FQ9 ethanolamine ammonia-lyase BMD_2521 ENOG4105CPD ethanolamine ammonia-lyase BMD_2522 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase BMD_2525 ENOG4108IQI permease BMD_2527 ENOG4108Z7F N-acetyltransferase BMD_2532 ENOG4107S9D Alpha beta hydrolase BMD_2534 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BMD_2535 ENOG4105K4P CoA-binding domain protein BMD_2536 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BMD_2538 ENOG4105W8X HesB YadR YfhF-family protein BMD_2541 ENOG41067CD Small, acid-soluble spore protein Tlp BMD_2543 ENOG41075ZD Small, acid-soluble spore protein N BMD_2545 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BMD_2546 ENOG4108I0Z Aconitate hydratase BMD_2547 ENOG410746C Acid-soluble spore protein O BMD_2548 ENOG4107DZX Small, acid-soluble spore protein P BMD_2550 ENOG4105FDF Could be involved in DNA repair (By similarity) BMD_2558 ENOG4105C7W Xanthine dehydrogenase BMD_2560 ENOG4105XRQ Xanthine dehydrogenase accessory factor BMD_2572 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BMD_2574 ENOG4105F27 Major Facilitator BMD_2575 ENOG4105EWC Purine nucleoside phosphorylase BMD_2576 ENOG4105VBF alkaline shock protein BMD_2579 ENOG4107U9T Pfam:Ribonuclease_BN BMD_2581 ENOG4105C6X Major Facilitator BMD_2582 ENOG4105DXB Major Facilitator superfamily BMD_2583 ENOG4107SWG transcriptional regulator MERR family BMD_2585 ENOG4108V2W Carbonate dehydratase BMD_2586 ENOG4105CHH sulfate transporter BMD_2587 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMD_2588 ENOG4105BZU Histidine kinase BMD_2591 ENOG4107QTZ amino acid BMD_2593 ENOG4108ZRV stage ii sporulation protein p BMD_2594 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase BMD_2596 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BMD_2597 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BMD_2598 ENOG4108P62 biosynthesis protein (CbiG) BMD_2599 ENOG4105CIA precorrin-4 C(11)-methyltransferase BMD_2601 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase BMD_2602 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) BMD_2603 ENOG41081F0 Precorrin-8x methylmutase BMD_2604 ENOG4108JTQ reductase BMD_2605 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BMD_2606 ENOG4105E4R Precorrin-3B C17-methyltransferase BMD_2609 ENOG4105DER m42 family BMD_2619 ENOG4107TT2 Auxin Efflux Carrier BMD_2620 ENOG4105C6K Malic enzyme BMD_2621 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B BMD_2622 ENOG4105DJB Major Facilitator Superfamily BMD_2624 ENOG41069ZX BMD_2625 ENOG41069ZX BMD_2626 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BMD_2627 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BMD_2628 ENOG4106P55 Transcriptional regulator BMD_2629 ENOG4107TT2 Auxin Efflux Carrier BMD_2633 ENOG4105DEN Luciferase family BMD_2634 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BMD_2635 ENOG4105CQB FAD linked oxidase domain protein BMD_2637 ENOG4107R7Y intracellular protease Pfpi family BMD_2639 ENOG4105CY2 Citrate transporter BMD_2640 ENOG4105C0A alcohol dehydrogenase BMD_2643 ENOG4105CJ1 ABC, transporter BMD_2645 ENOG4105WH1 Two component transcriptional regulator luxr family BMD_2653 ENOG4105DEN Luciferase family BMD_2655 ENOG4107T5V SNARE associated Golgi BMD_2656 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BMD_2657 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BMD_2658 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BMD_2661 ENOG4105CUB amino acid BMD_2674 ENOG4105UQX Mate efflux family protein BMD_2675 ENOG4105CW7 secretion protein, HlyD family BMD_2677 ENOG4105FS7 Transcriptional regulator BMD_2678 ENOG4105CGK Exodeoxyribonuclease III BMD_2680 ENOG41090KN UPF0303 protein BMD_2681 ENOG4105D9R oxidoreductase BMD_2682 ENOG4105E98 transcriptional regulator DeoR family BMD_2684 ENOG4108TTB tellurium resistance protein BMD_2685 ENOG4106FN3 tellurium resistance protein BMD_2686 ENOG4106FN3 tellurium resistance protein BMD_2687 ENOG4108N0M stress protein BMD_2688 ENOG4105CGH 5'-nucleotidase BMD_2691 ENOG4108TU7 Inherit from COG: (ABC) transporter BMD_2692 ENOG4105CJ1 ABC, transporter BMD_2694 ENOG4106KE4 Dehydrogenase BMD_2696 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BMD_2706 ENOG4105CYC Transferase BMD_2707 ENOG4105DY9 regulatoR BMD_2708 ENOG4105H67 Protein of unknown function (DUF421) BMD_2709 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_2710 ENOG41069ER domain protein BMD_2711 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BMD_2719 ENOG4105DNP FAD linked oxidase domain protein BMD_2721 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BMD_2731 ENOG4105DWT malate dehydrogenase (quinone) BMD_2738 ENOG4105I1K ABC transporter BMD_2739 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BMD_2742 ENOG4108UB7 BMD_2747 ENOG4105BZW Glycerate kinase BMD_2748 ENOG4107QQ0 gntp family BMD_2749 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BMD_2750 ENOG4105C0A alcohol dehydrogenase BMD_2751 ENOG4105KAF membrAne BMD_2755 ENOG4105BZ4 penicillin-binding protein BMD_2760 ENOG4108QY0 Membrane BMD_2762 ENOG4107SJW iron permease, FTR1 BMD_2766 ENOG4105DYS nad(p)h dehydrogenase (quinone) BMD_2771 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) BMD_2772 ENOG4107X8Z Acyl-protein synthetase, LuxE BMD_2774 ENOG4105H3G oxidoreductase BMD_2775 ENOG4107RCI amp-dependent synthetase and ligase BMD_2782 ENOG4107QTZ amino acid BMD_2784 ENOG4105K70 DNA-binding protein BMD_2785 ENOG4108NHD germination protein BMD_2786 ENOG4108Q8B Spore germination protein BMD_2792 ENOG4105C1J atp-dependent rna helicase BMD_2794 ENOG4105VEQ Cold shock protein BMD_2796 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase BMD_2798 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid BMD_2800 ENOG4105DCM major facilitator superfamily BMD_2801 ENOG410645S MarR family Transcriptional regulator BMD_2803 ENOG4108IPJ Membrane BMD_2804 ENOG4105C3M thioredoxin reductase BMD_2811 ENOG4105IW1 AmiS UreI transporter BMD_2812 ENOG4105D9N nucleoside BMD_2813 ENOG4105KG3 cytidine deaminase BMD_2814 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BMD_2817 ENOG4107RHR regulatoR BMD_2823 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BMD_2826 ENOG4105D0M Protease HtpX homolog BMD_2827 ENOG41069FQ Metallo-beta-lactamase superfamily BMD_2828 ENOG4105KK4 UPF0060 membrane protein BMD_2833 ENOG4105CRW Short chain fatty acid transporter BMD_2838 ENOG4105CUC YeeE YedE family protein BMD_2839 ENOG4108M8H domain protein BMD_2841 ENOG4107QW4 alcohol dehydrogenase BMD_2842 ENOG4107V2S Transcriptional regulator BMD_2852 ENOG4105CHR reductase BMD_2853 ENOG4105CPQ Dehydrogenase BMD_2858 ENOG4107SUZ Sodium/hydrogen exchanger family BMD_2859 ENOG4105C37 (CBS) domain BMD_2864 ENOG4108JQ7 (ABC) transporter BMD_2866 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BMD_2867 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BMD_2868 ENOG4107RRN ABC transporter substrate-binding protein BMD_2870 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BMD_2874 ENOG4107Y9E nuclease BMD_2876 ENOG4105DWT malate dehydrogenase (quinone) BMD_2877 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BMD_2878 ENOG4105J7I hydrolase BMD_2888 ENOG4107HP6 Transcriptional regulator BMD_2889 ENOG4105ERH Fumarylacetoacetate hydrolase BMD_2890 ENOG4105C82 Malate synthase BMD_2891 ENOG4105CQB FAD linked oxidase domain protein BMD_2892 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BMD_2893 ENOG4105CQB FAD linked oxidase domain protein BMD_2894 ENOG4105DAA L-lactate BMD_2900 ENOG4105DA5 (ABC) transporter BMD_2901 ENOG41069JR BMD_2909 ENOG4107I77 yiaA/B two helix domain BMD_2912 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BMD_2914 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BMD_2916 ENOG4105H67 Protein of unknown function (DUF421) BMD_2917 ENOG4108VXD carboxy-peptidase BMD_2920 ENOG4105BZU Histidine kinase BMD_2921 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BMD_2925 ENOG4105C7S Dehydrogenase BMD_2926 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BMD_2929 ENOG4108X3M OsmC Ohr family protein BMD_2931 ENOG4105DHF Membrane BMD_2938 ENOG4108IV0 ABC, transporter BMD_2939 ENOG4105C0Z ABC transporter BMD_2940 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BMD_2941 ENOG4105C32 Amino acid ABC transporter (Permease) BMD_2944 ENOG4105BZU Histidine kinase BMD_2949 ENOG4105D74 hydrolase BMD_2952 ENOG4105RHY Pfam:UPF0157 BMD_2954 ENOG4105FDT acyl-CoA dehydrogenase BMD_2962 ENOG4108IPW abc transporter atp-binding protein BMD_2963 ENOG4105EHG Permease protein BMD_2964 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BMD_2966 ENOG4107QTZ amino acid BMD_2968 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BMD_2970 ENOG41080HJ 6-phospho 3-hexuloisomerase BMD_2974 ENOG4105DJB Major Facilitator Superfamily BMD_2975 ENOG4105D7K pfkb domain protein BMD_2978 ENOG4105EWK phytoene BMD_2979 ENOG41076QQ Glycosyl transferase, family 2 BMD_2989 ENOG4105CQM Urea amidohydrolase subunit alpha BMD_2991 ENOG4108YZ9 Urea amidohydrolase subunit gamma BMD_2992 ENOG4108I0Q anthranilate phosphoribosyltransferase BMD_2994 ENOG41069ER domain protein BMD_2995 ENOG4108DBC nitroreductase BMD_2997 ENOG4107ZTW SNARE associated Golgi BMD_2999 ENOG4105FBA Phospholipase Carboxylesterase BMD_3000 ENOG4105BZ4 penicillin-binding protein BMD_3002 ENOG4105T38 integral membrane protein BMD_3007 ENOG4105BZ1 (ABC) transporter BMD_3012 ENOG4105K7W phage-related replication protein BMD_3016 ENOG4108RMU ferritin dps family protein BMD_3017 ENOG4108WPJ Ferritin-like domain BMD_3020 ENOG4105C37 (CBS) domain BMD_3022 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BMD_3028 ENOG4105EVN Prephenate dehydrogenase BMD_3030 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BMD_3032 ENOG4105FGV Chromate BMD_3033 ENOG4105CAH Chromate BMD_3034 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BMD_3035 ENOG4105C5R Aminotransferase BMD_3037 ENOG4105G9B Transcriptional regulator BMD_3040 ENOG4105CH6 catalase BMD_3042 ENOG4105C8J )-transporter BMD_3050 ENOG410635A Membrane BMD_3051 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BMD_3052 ENOG4105C3F Signal peptidase i BMD_3056 ENOG4105YVS arsR family transcriptional regulator BMD_3058 ENOG4108DBC nitroreductase BMD_3061 ENOG4105RHY Pfam:UPF0157 BMD_3062 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BMD_3063 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BMD_3066 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BMD_3069 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BMD_3070 ENOG4108JYZ YitT family BMD_3074 ENOG4107AYK membrAne BMD_3075 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BMD_3077 ENOG4105BZN citrate synthase BMD_3079 ENOG4105CMU LysR family (Transcriptional regulator BMD_3080 ENOG4105FDR Membrane BMD_3085 ENOG4105BZU Histidine kinase BMD_3093 ENOG4107BMA Transglycosylase associated protein BMD_3096 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BMD_3099 ENOG4108IJ0 Aspartate ammonia-lyase BMD_3100 ENOG4105HDK L-asparaginase BMD_3101 ENOG4108IMY Transcriptional regulator BMD_3104 ENOG4105CT4 transporter BMD_3105 ENOG4105WAB arsR family transcriptional regulator BMD_3109 ENOG4107QTZ amino acid BMD_3110 ENOG4108Z40 Transcriptional regulator BMD_3115 ENOG4105C6K Malic enzyme BMD_3116 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BMD_3118 ENOG41068WN BMD_3121 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BMD_3122 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BMD_3125 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_3126 ENOG41067TZ transcriptional regulator, MarR family BMD_3127 ENOG4107TXC Transcriptional regulator BMD_3128 ENOG4108MK9 spermidine N(1)-acetyltransferase BMD_3139 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BMD_3144 ENOG4105VCH membrane BMD_3146 ENOG4105CI2 imidazolone-5-propionate hydrolase BMD_3148 ENOG4108KGH TRANSCRIPTIONal BMD_3149 ENOG41068WN BMD_3153 ENOG41060D1 Quinol oxidase BMD_3155 ENOG4105BZ9 Cytochrome C oxidase, subunit I BMD_3156 ENOG4105E2S oxidase) subunit II BMD_3165 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase BMD_3168 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BMD_3169 ENOG410829K Lysine exporter protein (Lyse ygga) BMD_3170 ENOG4107QTZ amino acid BMD_3176 ENOG41087NI Sulfite exporter TauE/SafE BMD_3178 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BMD_3180 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BMD_3185 ENOG4108JYZ YitT family BMD_3190 ENOG4108R9S DSBA oxidoreductase BMD_3191 ENOG4105D0M Protease HtpX homolog BMD_3199 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BMD_3201 ENOG4105Y7M Transcriptional regulator, TetR family BMD_3202 ENOG410814C multidrug resistance protein BMD_3203 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BMD_3204 ENOG4105VEQ Cold shock protein BMD_3205 ENOG4108QY0 Membrane BMD_3208 ENOG4108RYK Nad-dependent epimerase dehydratase BMD_3215 ENOG4105WEF catalase BMD_3217 ENOG4108IPW abc transporter atp-binding protein BMD_3218 ENOG4105CM4 permease protein BMD_3219 ENOG4105DHS permease protein BMD_3220 ENOG4105F0V Cell wall hydrolase BMD_3223 ENOG4105NF4 modulator of drug activity BMD_3224 ENOG4105C3F Signal peptidase i BMD_3229 ENOG4105E98 transcriptional regulator DeoR family BMD_3230 ENOG4107STF Involved in phosphonate degradation (By similarity) BMD_3232 ENOG4105C98 muts2 protein BMD_3234 ENOG4108UMN azlc family BMD_3235 ENOG4108JCI Transcriptional regulator BMD_3236 ENOG4108ZCF integral membrane protein BMD_3239 ENOG41062ES Transcriptional regulator BMD_3246 ENOG4105NAE bifunctional deaminase-reductase domain protein BMD_3248 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BMD_3249 ENOG41067SE Tetr family transcriptional regulator BMD_3251 ENOG4105WEF catalase BMD_3255 ENOG4105N14 lysine exporter protein LysE YggA BMD_3256 ENOG4106AXJ AraC family transcriptional regulator BMD_3257 ENOG4105BZU Histidine kinase BMD_3268 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BMD_3272 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BMD_3273 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BMD_3274 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BMD_3275 ENOG4105BZU Histidine kinase BMD_3276 ENOG4105EFI regulatoR BMD_3277 ENOG4105JAB phenazine biosynthesis protein, phzf family BMD_3280 ENOG4105BZU Histidine kinase BMD_3281 ENOG4105D9U N-acetyltransferase BMD_3282 ENOG4105MWK D-amino acid dehydrogenase, small subunit BMD_3288 ENOG4107QM2 Aldo Keto reductase BMD_3291 ENOG4108UZ3 Transporter BMD_3292 ENOG4108MCI Transcriptional regulator, ARAC family BMD_3295 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) BMD_3297 ENOG4107ETC gas vesicle protein BMD_3303 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth BMD_3306 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth BMD_3307 ENOG4107KM7 Heat induced stress protein YflT BMD_3309 ENOG4105EGI Transcriptional regulator BMD_3310 ENOG41081I9 integral membrane protein BMD_3312 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BMD_3318 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BMD_3319 ENOG4105F6J Alpha beta hydrolase fold BMD_3321 ENOG4108IYU L-aspartate oxidase BMD_3322 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BMD_3323 ENOG4106FTQ Taurine ABC transporter, periplasmic BMD_3325 ENOG4105E2B Taurine dioxygenase BMD_3326 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_3331 ENOG4105FBW Monooxygenase BMD_3332 ENOG4105C1G acyl-Coa dehydrogenase BMD_3333 ENOG4105CPQ Dehydrogenase BMD_3334 ENOG4105CJZ response regulator BMD_3335 ENOG4105EWM Histidine kinase BMD_3336 ENOG4105C19 ABC transporter BMD_3340 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BMD_3342 ENOG41087NI Sulfite exporter TauE/SafE BMD_3343 ENOG4105VFE sira family BMD_3344 ENOG4107TPS domain protein BMD_3345 ENOG4105VFE sira family BMD_3348 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BMD_3349 ENOG4105VFE sira family BMD_3350 ENOG4105XTG Pfam:DUF156 BMD_3354 ENOG4105GZI Transcriptional regulator BMD_3358 ENOG4108S3Y transcriptional regulator BMD_3359 ENOG4105CS2 ec 3.2.1.21 BMD_3362 ENOG4105X3H Excalibur domain protein BMD_3365 ENOG4105N14 lysine exporter protein LysE YggA BMD_3366 ENOG41080UX Methyltransferase BMD_3368 ENOG4107RSM transcriptional regulator BMD_3371 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BMD_3374 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BMD_3375 ENOG4108TVJ Nitroreductase BMD_3376 ENOG4105C26 Dehydrogenase BMD_3379 ENOG4108V0P LemA family BMD_3380 ENOG4108ZJ4 polysaccharide deacetylase BMD_3383 ENOG4105KVH Transcriptional regulator BMD_3384 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BMD_3385 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BMD_3386 ENOG41068WN BMD_3398 ENOG4108W15 Protein of unknown function (DUF1456) BMD_3400 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BMD_3406 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BMD_3410 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_3416 ENOG4105CHH sulfate transporter BMD_3418 ENOG4105CT4 transporter BMD_3419 ENOG4105C8M UPF0272 protein BMD_3420 ENOG4105C8M UPF0272 protein BMD_3421 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase BMD_3422 ENOG4105DVM PP-loop domain protein BMD_3423 ENOG4105DMW Dehydrogenase reductase BMD_3425 ENOG4105D2H Uronic isomerase BMD_3430 ENOG4105CJ1 ABC, transporter BMD_3436 ENOG4108X4Q Hydrolase BMD_3441 ENOG4105KAC Antibiotic biosynthesis monooxygenase BMD_3443 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMD_3446 ENOG4105CJ1 ABC, transporter BMD_3451 ENOG4105VMP Transcriptional regulator BMD_3453 ENOG4105EGI Transcriptional regulator BMD_3456 ENOG4107QP6 Xylose isomerase domain protein TIM barrel BMD_3457 ENOG4105ID8 Transcriptional regulator, ARAC family BMD_3459 ENOG4105ETE Transcriptional regulator (LacI family BMD_3460 ENOG4105F0H myo-inositol catabolism protein BMD_3461 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BMD_3465 ENOG4105DH8 myo-inositol catabolism BMD_3466 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) BMD_3468 ENOG4105D2N Aldolase BMD_3469 ENOG4107VG4 Xylose isomerase domain protein TIM barrel BMD_3470 ENOG4107QNK )-transporter BMD_3471 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BMD_3472 ENOG4105KRI phosphocarrier protein (HPr BMD_3473 ENOG4105DQ4 alcohol dehydrogenase BMD_3474 ENOG4105VUF Transcriptional regulator BMD_3477 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BMD_3482 ENOG4105VEQ Cold shock protein BMD_3485 ENOG4108VXD carboxy-peptidase BMD_3487 ENOG4107QKS N-acylglucosamine 2-epimerase BMD_3491 ENOG4106SCS STAS domain BMD_3493 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BMD_3497 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BMD_3500 ENOG4105F1N DNA alkylation repair BMD_3508 ENOG4105JXH GntR family transcriptional regulator BMD_3513 ENOG4105XPP Protein of unknown function (DUF1275) BMD_3515 ENOG4105E98 transcriptional regulator DeoR family BMD_3516 ENOG410667J hydrolase BMD_3518 ENOG4105C5I Dehydrogenase BMD_3527 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BMD_3529 ENOG4107QNK )-transporter BMD_3530 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BMD_3532 ENOG4105CMG Carbohydrate kinase BMD_3533 ENOG4105CMD Transcriptional regulator, GntR family BMD_3534 ENOG4107TVP HD domain protein BMD_3536 ENOG4105CE1 Ferrous iron transport protein b BMD_3537 ENOG4105CE1 Ferrous iron transport protein b BMD_3538 ENOG4105CE1 Ferrous iron transport protein b BMD_3541 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase BMD_3551 ENOG4108RPX mosc domain containing protein BMD_3552 ENOG4105D9N nucleoside BMD_3560 ENOG41069DP small acid-soluble spore protein BMD_3566 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BMD_3567 ENOG4105C85 amino acid BMD_3568 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BMD_3569 ENOG4106IPI cyclase, family BMD_3570 ENOG41069HH 4-oxalocrotonate tautomerase BMD_3576 ENOG4105KME endoribonuclease L-psp BMD_3579 ENOG4107V0Z fmn reductase BMD_3580 ENOG4105U1N riboflavin BMD_3581 ENOG4105EFA 4-hydroxyphenylacetate BMD_3587 ENOG4105CT4 transporter BMD_3588 ENOG4105CPQ Dehydrogenase BMD_3589 ENOG4105PGZ NB-ARC domain BMD_3595 ENOG4108ZMX Domain of unknown function (DU1801) BMD_3596 ENOG4105CZ9 Domain of unknown function (DU1801) BMD_3601 ENOG4105D7N magnesium and cobalt transport protein CorA BMD_3602 ENOG4105CZN Potassium uptake protein BMD_3604 ENOG4105D4Y metalloprotease BMD_3605 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BMD_3608 ENOG4108Z7G MaoC domain protein dehydratase BMD_3609 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) BMD_3611 ENOG4105DND Transcriptional regulator BMD_3612 ENOG4105CIS alcohol dehydrogenase BMD_3613 ENOG41082BM Transcriptional regulator, arsr family BMD_3617 ENOG4105DTD Dehydrogenase BMD_3619 ENOG4105IE8 Alpha-ketoglutarate permease BMD_3620 ENOG4107QP6 Xylose isomerase domain protein TIM barrel BMD_3621 ENOG4105CIB oxidoreductase Domain protein BMD_3625 ENOG4108NEV two component transcriptional regulator, LytTR family BMD_3626 ENOG4105BZU Histidine kinase BMD_3629 ENOG4105PGS Spore coat protein BMD_3630 ENOG4105E2A Dehydrogenase BMD_3640 ENOG4105MDS 4-oxalocrotonate tautomerase BMD_3641 ENOG4107V2S Transcriptional regulator BMD_3651 ENOG4105CHJ isochorismatase hydrolase BMD_3653 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BMD_3654 ENOG4108VGI doxx family BMD_3656 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BMD_3657 ENOG4105KNY Microcompartments protein BMD_3658 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml BMD_3661 ENOG4105KNY Microcompartments protein BMD_3662 ENOG4108EKI Dehydrogenase BMD_3663 ENOG4106D67 ethanolamine utilization protein BMD_3664 ENOG4107FQ9 ethanolamine ammonia-lyase BMD_3665 ENOG4105CPD ethanolamine ammonia-lyase BMD_3666 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase BMD_3667 ENOG4106S4J ethanolamine utilization protein EutP BMD_3668 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place BMD_3669 ENOG4105ENY Ethanolamine utilization protein eutH BMD_3676 ENOG4105KBX Transcriptional regulator, TetR family BMD_3677 ENOG4105KPY Small multidrug resistance protein BMD_3678 ENOG4105RXJ BMD_3681 ENOG4105JSC dimethylmenaquinone methyltransferase BMD_3683 ENOG4105D4T Citrate transporter BMD_3685 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_3688 ENOG4105ST3 Transcriptional regulator BMD_3693 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BMD_3694 ENOG4105DWV Homoserine O-trans-acetylase BMD_3696 ENOG4105C5Y PTS System BMD_3697 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BMD_3698 ENOG4108NGU Transcriptional regulator BMD_3703 ENOG4108T9Y Inner membrane protein ydcZ BMD_3704 ENOG4107V2S Transcriptional regulator BMD_3706 ENOG4108Q5Y Membrane BMD_3707 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BMD_3708 ENOG4108IJ0 Aspartate ammonia-lyase BMD_3711 ENOG4107BMA Transglycosylase associated protein BMD_3714 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BMD_3715 ENOG4105CV8 reductase BMD_3716 ENOG4105YWU small acid-soluble spore protein BMD_3723 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BMD_3728 ENOG4107FCW Abortive infection protein BMD_3733 ENOG4107RB3 L-asparaginase BMD_3737 ENOG4105K7K Transcriptional regulator BMD_3739 ENOG4108W5M transcriptional regulator BMD_3741 ENOG4105F27 Major Facilitator BMD_3742 ENOG4105WDR BMD_3743 ENOG4107KM7 Heat induced stress protein YflT BMD_3745 ENOG4105C6K Malic enzyme BMD_3755 ENOG4105YWU small acid-soluble spore protein BMD_3757 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BMD_3759 ENOG4105CG3 alpha amylase, catalytic region BMD_3761 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BMD_3767 ENOG4105YWU small acid-soluble spore protein BMD_3775 ENOG41086D8 Transcriptional regulator BMD_3781 ENOG4105CVM Molybdenum cofactor synthesis domain protein BMD_3783 ENOG4108RIR Molybdenum cofactor biosynthesis protein BMD_3790 ENOG4105C7F AcnD-accessory protein PrpF BMD_3791 ENOG4108KAM Transcriptional regulator BMD_3797 ENOG4106I4J membrane BMD_3798 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BMD_3801 ENOG4105K4H Nlp p60 protein BMD_3802 ENOG4105CZM Major Facilitator BMD_3803 ENOG4107MII Sugar-specific transcriptional regulator TrmB BMD_3805 ENOG4105QIV RNA polymerase BMD_3812 ENOG4105C85 amino acid BMD_3813 ENOG4105C26 Dehydrogenase BMD_3815 ENOG4108XI2 Domain of unknown function (DUF1963) BMD_3819 ENOG4108ZRV stage ii sporulation protein p BMD_3821 ENOG4105BZU Histidine kinase BMD_3824 ENOG4107QJZ Glycosyl transferase, family 2 BMD_3831 ENOG4105CTD carboxy-peptidase BMD_3832 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BMD_3833 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BMD_3843 ENOG4105VUF Transcriptional regulator BMD_3844 ENOG4105CPC Aldo Keto reductase BMD_3846 ENOG4107SWG transcriptional regulator MERR family BMD_3852 ENOG4108HKT sucrose-6-phosphate hydrolase BMD_3860 ENOG4105C19 ABC transporter BMD_3862 ENOG4105EWM Histidine kinase BMD_3863 ENOG4105CJZ response regulator BMD_3865 ENOG4105ME7 Membrane BMD_3866 ENOG4105XTG Pfam:DUF156 BMD_3867 ENOG4105WFK nuclease BMD_3869 ENOG4105EEM helicase BMD_3870 ENOG4105E39 Enoyl-CoA hydratase BMD_3871 ENOG4105KVH Transcriptional regulator BMD_3874 ENOG4106A3M Cytochrome p-450 BMD_3876 ENOG4105CKK Glycosyl transferase, family 2 BMD_3877 ENOG4107QQG Dehydrogenase BMD_3882 ENOG4106YBV Methyl-accepting chemotaxis BMD_3884 ENOG4108P49 AntiSigma factor BMD_3885 ENOG4105JVQ RNA Polymerase BMD_3886 ENOG4108ZJ4 polysaccharide deacetylase BMD_3890 ENOG4108IQI permease BMD_3892 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BMD_3894 ENOG4105CZN Potassium uptake protein BMD_3895 ENOG4107ZYR domain protein BMD_3899 ENOG4105C0H protease BMD_3901 ENOG4105F3H Histidine kinase BMD_3903 ENOG4108S4H thioesterase Superfamily protein BMD_3904 ENOG4105DRR Transcriptional regulator, GntR family BMD_3906 ENOG41064HX Suppressor of fused protein (SUFU) BMD_3907 ENOG4105DC7 peptidase M24 BMD_3909 ENOG4108RCF TRANSCRIPTIONal BMD_3911 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BMD_3914 ENOG4105E90 ABC transporter BMD_3915 ENOG4108IJ8 ABC transporter BMD_3918 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMD_3920 ENOG4108HGU Histidine kinase BMD_3921 ENOG4107TSN permease BMD_3922 ENOG4105CK2 sodium dicarboxylate symporter BMD_3924 ENOG4105EA8 2-Nitropropane dioxygenase BMD_3929 ENOG4108RCF TRANSCRIPTIONal BMD_3930 ENOG4105E0M Sulfatase BMD_3933 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BMD_3937 ENOG4105JHY Membrane BMD_3938 ENOG4105J7D transcriptional regulator BMD_3940 ENOG4107RSM transcriptional regulator BMD_3942 ENOG4108Z7F N-acetyltransferase BMD_3943 ENOG4108RYK Nad-dependent epimerase dehydratase BMD_3944 ENOG4105KT7 mgtC SapB transporter BMD_3945 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BMD_3946 ENOG4105K7W phage-related replication protein BMD_3948 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BMD_3951 ENOG4105C85 amino acid BMD_3961 ENOG4105C1Q protoporphyrinogen oxidase BMD_3962 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BMD_3963 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) BMD_3966 ENOG4108NIW Leucine export protein LeuE BMD_3970 ENOG4105D64 Mechanosensitive ion channel BMD_3971 ENOG4105K4I Scp-like extracellular BMD_3972 ENOG4105C37 (CBS) domain BMD_3974 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BMD_3975 ENOG4107YZX Universal stress protein BMD_3977 ENOG4105CTQ phosphohexokinase BMD_3982 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BMD_3985 ENOG4108NHD germination protein BMD_3989 ENOG4105DVE abc transporter atp-binding protein BMD_3992 ENOG4108JYZ YitT family BMD_3995 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BMD_3997 ENOG4105CIG ABC transporter BMD_4000 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BMD_4002 ENOG4105C5Y PTS System BMD_4005 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BMD_4009 ENOG4105CHH sulfate transporter BMD_4010 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BMD_4012 ENOG4106Z5R BMD_4013 ENOG410841Q phosphoesterase PA-phosphatase related protein BMD_4015 ENOG4108N23 SpoOM-related protein BMD_4016 ENOG4105D9P serine threonine protein kinase BMD_4021 ENOG4105VSD UPF0346 protein BMD_4022 ENOG4108TGC Acyltransferase BMD_4023 ENOG4105F0I Aminotransferase BMD_4025 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BMD_4026 ENOG4108TSC N-acetyltransferase BMD_4027 ENOG4107S4Y M20 DapE family protein YgeY BMD_4030 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BMD_4033 ENOG4105BZU Histidine kinase BMD_4038 ENOG41090WU lipolytic protein G-D-S-L family BMD_4039 ENOG4108KF3 Electron transport protein SCO1 SenC BMD_4041 ENOG4108RCR degv family BMD_4043 ENOG4105C7B Threonine dehydratase BMD_4044 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BMD_4045 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BMD_4046 ENOG4105CIY formyltetrahydrofolate deformylase BMD_4053 ENOG4105DY8 decarboxylase BMD_4057 ENOG4105CVP deoxyribo-dipyrimidine photolyase BMD_4058 ENOG4105BZU Histidine kinase BMD_4061 ENOG4105C26 Dehydrogenase BMD_4063 ENOG4108JPW Aminotransferase BMD_4066 ENOG4108U5N UPF0316 protein BMD_4067 ENOG4107QIV Cytochrome c biogenesis protein BMD_4069 ENOG4105BZ1 (ABC) transporter BMD_4070 ENOG4105BZ1 (ABC) transporter BMD_4071 ENOG4105VXM UPF0154 protein BMD_4074 ENOG4105VPS UPF0291 protein BMD_4075 ENOG4108SVB resolvase BMD_4077 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BMD_4081 ENOG4105CKK Glycosyl transferase, family 2 BMD_4082 ENOG41076HS cation diffusion facilitator family transporter BMD_4083 ENOG4105C0X amino acid BMD_4086 ENOG4105C5F glutamine synthetase BMD_4087 ENOG4105KV4 Transcriptional regulator BMD_4088 ENOG4105CXI aluminum resistance protein BMD_4089 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BMD_4090 ENOG4105EN6 Membrane BMD_4091 ENOG4106F1P AAA ATPase, central domain protein BMD_4093 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BMD_4094 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BMD_4095 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BMD_4096 ENOG4105CUB amino acid BMD_4099 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BMD_4100 ENOG4105DQU oxidoreductase, subunit beta BMD_4101 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BMD_4103 ENOG4105MCT stage V sporulation protein S BMD_4104 ENOG4105D48 metallophosphoesterase BMD_4106 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BMD_4107 ENOG4105CEV competence damage-inducible protein BMD_4108 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BMD_4111 ENOG4105XZV Protein of unknown function (DUF3243) BMD_4112 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BMD_4116 ENOG4105UIB (ABC) transporter BMD_4117 ENOG4108JQ9 ABC transporter BMD_4118 ENOG4105DIH basic membrane BMD_4119 ENOG4105FDP GntR family transcriptional regulator BMD_4120 ENOG4105CNU cell division protein FtsK BMD_4122 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BMD_4124 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BMD_4126 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BMD_4127 ENOG4108S0H Dipicolinic acid synthetase, b subunit BMD_4128 ENOG4105E35 Dipicolinate synthase subunit A BMD_4130 ENOG4105C1V Peptidase, M16 BMD_4132 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BMD_4133 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BMD_4134 ENOG4105DTN riboflavin biosynthesis protein ribF BMD_4137 ENOG4105W7A Protein of unknown function (DUF503) BMD_4138 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BMD_4139 ENOG4105VHM ribosomal protein BMD_4140 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BMD_4141 ENOG4105CHV Transcription elongation factor NusA BMD_4142 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BMD_4143 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BMD_4144 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BMD_4145 ENOG4105DZP Membrane-associated zinc metalloprotease BMD_4146 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BMD_4147 ENOG4105KNE Phosphatidate cytidylyltransferase BMD_4148 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BMD_4149 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BMD_4151 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BMD_4152 ENOG4105CE9 30S ribosomal protein S2 BMD_4154 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMD_4155 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BMD_4156 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BMD_4157 ENOG4105CBS Chea signal transduction histidine kinase BMD_4158 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BMD_4160 ENOG4105FZW flagellar biosynthesis regulator FlhF BMD_4161 ENOG4105D7B Flagellar biosynthesis protein flha BMD_4162 ENOG4105D00 flagellar biosynthetic protein flhB BMD_4163 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BMD_4164 ENOG4105VS8 Flagellar biosynthetic protein fliq BMD_4165 ENOG4105CN7 Flagellar biosynthetic protein FliP BMD_4167 ENOG4107YTP response regulator receiver protein BMD_4168 ENOG4105DD5 Flagellar motor switch protein BMD_4169 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BMD_4171 ENOG41068WV flagellar FlbD family protein BMD_4172 ENOG4108JQA flagellar BMD_4173 ENOG410822I Flagellar hook capping protein BMD_4176 ENOG4106YF4 Flagellar biosynthesis chaperone BMD_4179 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BMD_4180 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BMD_4181 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BMD_4182 ENOG4108ZC9 flagellar basal-body rod protein flgc BMD_4183 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BMD_4184 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) BMD_4185 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BMD_4186 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BMD_4187 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BMD_4188 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BMD_4189 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BMD_4190 ENOG4105C79 DNA protecting protein DprA BMD_4191 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BMD_4192 ENOG4105CMV Succinyl-CoA synthetase subunit beta BMD_4196 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BMD_4198 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BMD_4200 ENOG4105VB6 UPF0109 protein BMD_4201 ENOG4105K5M 30s ribosomal protein S16 BMD_4203 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BMD_4204 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BMD_4205 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BMD_4206 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BMD_4207 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BMD_4208 ENOG4105CHR reductase BMD_4209 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BMD_4210 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BMD_4211 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BMD_4212 ENOG4105CB5 ATP-dependent DNA helicase recG BMD_4213 ENOG4105EJQ L-serine dehydratase BMD_4216 ENOG4105DP4 dak2 domain fusion protein ylov BMD_4217 ENOG4108ZAA Alkaline-shock protein BMD_4218 ENOG4105VB9 50S ribosomal protein l28 BMD_4219 ENOG4105FJ0 thiamine BMD_4220 ENOG4105DJV ribulose-phosphate 3-epimerase BMD_4221 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BMD_4222 ENOG4105D9P serine threonine protein kinase BMD_4223 ENOG4108ZF3 Phosphatase BMD_4224 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BMD_4225 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BMD_4226 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BMD_4228 ENOG4105C25 Primosomal protein n' BMD_4229 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BMD_4231 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BMD_4232 ENOG4105KC4 UPF0296 protein BMD_4233 ENOG4105DSJ YicC domain protein BMD_4235 ENOG4105F23 Fibronectin-binding protein BMD_4236 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BMD_4239 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BMD_4242 ENOG4105CD3 dihydroorotase BMD_4243 ENOG4105CXT aspartate transcarbamylase BMD_4245 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BMD_4246 ENOG4105C34 Pseudouridine synthase BMD_4247 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BMD_4251 ENOG4105DBK s4 domain protein BMD_4252 ENOG41067XK integral membrane protein BMD_4253 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BMD_4254 ENOG4105DFA alanine racemase domain protein BMD_4255 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BMD_4256 ENOG4105WR5 sporulation protein, YlmC YmxH family BMD_4258 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMD_4259 ENOG4108AWX Sporulation factor SpoIIGA BMD_4260 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BMD_4261 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BMD_4262 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BMD_4263 ENOG4105D4A Cell wall formation (By similarity) BMD_4264 ENOG4105CNI cell division protein FtsW BMD_4266 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BMD_4267 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BMD_4268 ENOG4105CJN penicillin-binding protein BMD_4269 ENOG4105CJN penicillin-binding protein BMD_4270 ENOG41068DC Essential cell division protein (By similarity) BMD_4272 ENOG41074B2 UPF0747 protein BMD_4275 ENOG4107QX3 carboxylase BMD_4276 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BMD_4277 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BMD_4278 ENOG4108YG3 N-acetyltransferase BMD_4280 ENOG4105E39 Enoyl-CoA hydratase BMD_4281 ENOG41067VY 50S ribosomal protein L32 BMD_4282 ENOG4105KNH Nucleic acid-binding protein BMD_4283 ENOG4105CDE UPF0348 protein BMD_4284 ENOG41063PX domain protein BMD_4285 ENOG4105D78 K07001 NTE family protein BMD_4286 ENOG4105H20 Sporulation integral membrane protein YlbJ BMD_4287 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BMD_4288 ENOG4106H78 methyltransferase BMD_4290 ENOG4105WUC UPF0298 protein BMD_4296 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BMD_4297 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BMD_4298 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BMD_4300 ENOG4108SXZ UPF0302 protein BMD_4301 ENOG41068YB TPR repeat-containing protein BMD_4302 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BMD_4304 ENOG4105CIH Imidazole acetol-phosphate transaminase BMD_4305 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BMD_4307 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BMD_4308 ENOG4105DK0 Indole-3-glycerol phosphate synthase BMD_4309 ENOG4108I0Q anthranilate phosphoribosyltransferase BMD_4311 ENOG4105D49 3-dehydroquinate synthase BMD_4312 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BMD_4313 ENOG4105BZU Histidine kinase BMD_4314 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BMD_4315 ENOG4105EAH synthase BMD_4316 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BMD_4317 ENOG4105XXQ heptaprenyl diphosphate synthase component I BMD_4318 ENOG4105WP2 Tryptophan RNA-binding attenuator protein BMD_4319 ENOG4105EUJ GTP cyclohydrolase i BMD_4320 ENOG4105K70 DNA-binding protein BMD_4321 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BMD_4324 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BMD_4329 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BMD_4330 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BMD_4331 ENOG4105E9Q Acyl-transferase BMD_4332 ENOG4105CAT Cytidine monophosphate kinase BMD_4335 ENOG4105MSI germination protein ypeb BMD_4336 ENOG4105F0V Cell wall hydrolase BMD_4338 ENOG4107RB3 L-asparaginase BMD_4339 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BMD_4341 ENOG4108S6Z Negative regulator of genetic competence BMD_4342 ENOG4108XDN Transcriptional regulator BMD_4343 ENOG4107RGJ metallophosphoesterase BMD_4346 ENOG4105I7S Abortive infection protein BMD_4347 ENOG4105C9U ATP-dependent DNA helicase RecQ BMD_4350 ENOG4108SAX Membrane BMD_4351 ENOG4108JQ1 Dehydrogenase BMD_4352 ENOG4105DR5 peptidase BMD_4353 ENOG4105BZU Histidine kinase BMD_4354 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMD_4355 ENOG4105CRE cytochrome C BMD_4356 ENOG4107TWT Cytochrome c biogenesis protein BMD_4357 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BMD_4358 ENOG4105FE9 pseudouridine synthase BMD_4360 ENOG4108JIC nucleoside recognition domain protein BMD_4361 ENOG4105DZ1 carboxypeptidase BMD_4362 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BMD_4363 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BMD_4367 ENOG4107ZE5 PPIases accelerate the folding of proteins BMD_4368 ENOG4105PTM secreted protein BMD_4371 ENOG4105G6R Stage v sporulation protein ae BMD_4373 ENOG4105CZ3 stage V sporulation protein ad BMD_4374 ENOG41090VF Stage v sporulation protein ac BMD_4377 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMD_4378 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BMD_4379 ENOG41082AN stage II sporulation protein BMD_4380 ENOG4105DZ1 carboxypeptidase BMD_4383 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BMD_4385 ENOG4105I3K Ferric uptake regulator, Fur family BMD_4386 ENOG4105MZ9 stage II sporulation protein m BMD_4387 ENOG4108YZ4 nudix hydrolase BMD_4389 ENOG4105CPC Aldo Keto reductase BMD_4391 ENOG4108IIH CoA-transferase subunit B BMD_4392 ENOG4105D6N CoA-transferase, subunit a BMD_4393 ENOG4105CHU acetyl-coa acetyltransferase BMD_4394 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BMD_4398 ENOG4108IXY short-chain dehydrogenase reductase BMD_4399 ENOG41069FQ Metallo-beta-lactamase superfamily BMD_4400 ENOG4105II7 pyrroline-5-carboxylate reductase BMD_4401 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BMD_4402 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BMD_4403 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BMD_4404 ENOG4105C26 Dehydrogenase BMD_4405 ENOG4105G9B Transcriptional regulator BMD_4409 ENOG4107SJI Dehydrogenase BMD_4410 ENOG4105BZ8 glutamate synthase BMD_4411 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BMD_4412 ENOG4108HNZ carboxyl transferase BMD_4414 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BMD_4415 ENOG4108QEG Membrane BMD_4416 ENOG4105CDA abc transporter atp-binding protein BMD_4417 ENOG4105E5Q amino acid AbC transporter BMD_4418 ENOG4108HW3 (ABC) transporter BMD_4419 ENOG4108Y6J UPF0403 protein BMD_4420 ENOG4105DJT lAO AO transport system ATPase BMD_4421 ENOG4105D5P Methylmalonyl-coA mutase BMD_4423 ENOG4105C7S Dehydrogenase BMD_4424 ENOG4105CPP Dehydrogenase, E1 component BMD_4428 ENOG4107RDP Dehydrogenase BMD_4430 ENOG4108JUB Transcriptional regulator BMD_4431 ENOG4106CCJ Protein of unknown function (DUF2627) BMD_4432 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BMD_4434 ENOG4105DUX Transporter BMD_4436 ENOG4107QQR Sporulation BMD_4437 ENOG4105S1Z Stage IV sporulation protein B BMD_4438 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BMD_4440 ENOG4105DX0 Hemolysin A BMD_4443 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BMD_4445 ENOG4105M7K Involved in the transcription termination process (By similarity) BMD_4446 ENOG4108ZSR alkaline shock protein BMD_4447 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BMD_4451 ENOG410644B Stage III sporulation protein af BMD_4453 ENOG4105KQ4 Stage iii sporulation protein ad BMD_4454 ENOG4108CQH stage III sporulation protein AC BMD_4455 ENOG4105KR5 Stage iii sporulation protein BMD_4456 ENOG4105CD2 stage iii sporulation protein aa BMD_4458 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BMD_4459 ENOG4105DC7 peptidase M24 BMD_4460 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BMD_4462 ENOG4105CBJ Metal-dependent enzyme BMD_4465 ENOG4105KST dependent repressor BMD_4467 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BMD_4468 ENOG4105WZW rhodanese family BMD_4470 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BMD_4471 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BMD_4472 ENOG4105C0D helicase BMD_4479 ENOG4106855 Competence protein BMD_4484 ENOG4105C5X domain protein BMD_4487 ENOG4105DKQ ROK family BMD_4489 ENOG4107ZXI Rhomboid family BMD_4492 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BMD_4493 ENOG410861F 50S ribosomal protein L33 BMD_4497 ENOG4108UTW Plays a role in the regulation of phosphate uptake BMD_4498 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BMD_4500 ENOG4107RF6 penicillin-binding protein BMD_4508 ENOG4105SXS Protein of unknown function (DUF456) BMD_4511 ENOG4107RCC Major Facilitator Superfamily BMD_4513 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BMD_4514 ENOG41063Y9 BMD_4515 ENOG4108U5J '-nucleotidase BMD_4516 ENOG4105N80 Ferric uptake regulator, Fur family BMD_4517 ENOG4105FAV ABC, transporter BMD_4518 ENOG4105FDK ABC transporter BMD_4520 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BMD_4523 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BMD_4524 ENOG4105EGD dinuclear metal center protein, YbgI family BMD_4527 ENOG4105C1G acyl-Coa dehydrogenase BMD_4528 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMD_4529 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BMD_4530 ENOG4107XJU UPF0178 protein BMD_4531 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BMD_4533 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BMD_4534 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BMD_4535 ENOG4105KG3 cytidine deaminase BMD_4536 ENOG4107YR5 Diacylglycerol kinase BMD_4537 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BMD_4538 ENOG4105CTJ Metal Dependent Phosphohydrolase BMD_4539 ENOG4105C9A Phoh family BMD_4541 ENOG41068P3 sporulation protein YqfC BMD_4544 ENOG4105F7J membrane-bound serine protease BMD_4545 ENOG4105KTH gatB Yqey BMD_4547 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BMD_4548 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BMD_4549 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BMD_4550 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BMD_4552 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BMD_4553 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BMD_4554 ENOG4105CSA Coproporphyrinogen iii oxidase BMD_4555 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BMD_4558 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BMD_4559 ENOG4105TQK DNA polymerase iii, delta' subunit BMD_4561 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BMD_4562 ENOG4108UK2 deaminase BMD_4563 ENOG4105KQC Competence protein BMD_4565 ENOG4105DXX methyltransferase BMD_4566 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BMD_4567 ENOG4108WF2 Metal Dependent Phosphohydrolase BMD_4568 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BMD_4569 ENOG410812S Rna-binding protein BMD_4570 ENOG4105E2X shikimate dehydrogenase BMD_4571 ENOG4105CQW ribosome biogenesis GTPase YqeH BMD_4572 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BMD_4574 ENOG4105DJ4 phosphatidylserine decarboxylase BMD_4575 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BMD_4577 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMD_4580 ENOG4105C28 cystathionine BMD_4582 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BMD_4583 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BMD_4586 ENOG4107XRG penicillin-binding protein BMD_4587 ENOG4105D3W isochorismatase BMD_4588 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BMD_4589 ENOG4105DBI uridine monophosphokinase BMD_4590 ENOG4105CFP Peptidase U32 BMD_4591 ENOG4105XYU peptidase (U32 family) BMD_4592 ENOG4108VQJ O-methyltransferase BMD_4593 ENOG4105HHA aminodeoxychorismate lyase BMD_4594 ENOG4105VPH UPF0473 protein BMD_4596 ENOG4105VBH UPF0297 protein BMD_4597 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BMD_4599 ENOG4105C02 permease BMD_4601 ENOG41060CR BMD_4602 ENOG4105C7H Helicase, RecD TraA family BMD_4604 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BMD_4605 ENOG4105C3J Cysteine desulfurase BMD_4607 ENOG4105D1H recombination factor protein RarA BMD_4608 ENOG4105E2Z phosphate ABC transporter (Permease BMD_4609 ENOG4105C8U phosphate abc transporter BMD_4610 ENOG4105CVA phosphate BMD_4611 ENOG4105CUZ uba thif-type nad fad binding protein BMD_4612 ENOG4105C9M aspartyl-trna synthetase BMD_4613 ENOG4105CUT histidyl-tRNA synthetase BMD_4615 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BMD_4616 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BMD_4617 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BMD_4618 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BMD_4619 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BMD_4620 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BMD_4622 ENOG4105CKP Polysaccharide Biosynthesis Protein BMD_4623 ENOG4108QG2 Membrane BMD_4624 ENOG4105NAP BMD_4625 ENOG4105VIE preprotein translocase, subunit YajC BMD_4626 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BMD_4627 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BMD_4628 ENOG41061AI Protein of unknown function (DUF2905) BMD_4629 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BMD_4630 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BMD_4635 ENOG4106678 morphogenetic protein associated with SpoVID BMD_4636 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BMD_4637 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BMD_4638 ENOG4108IYU L-aspartate oxidase BMD_4641 ENOG4105CQC Prephenate dehydratase BMD_4642 ENOG41090I5 UPF0735 ACT domain-containing protein BMD_4643 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BMD_4645 ENOG4105K46 50S ribosomal protein l27 BMD_4646 ENOG4105X36 (ribosomal) protein BMD_4648 ENOG4105C03 ribonuclease BMD_4651 ENOG4107QMS site-determining protein BMD_4652 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BMD_4653 ENOG4105YHC Rod shape-determining protein MreD BMD_4654 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BMD_4655 ENOG4105DFF Rod shape-determining protein mreb BMD_4656 ENOG4105W5Q DNA repair protein (RadC BMD_4659 ENOG4106A3R peptidase BMD_4661 ENOG4108SJC Membrane BMD_4662 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BMD_4663 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BMD_4665 ENOG4106AR7 Spore coat protein BMD_4666 ENOG41068KH stage VI sporulation protein D BMD_4667 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BMD_4668 ENOG4105D52 delta-aminolevulinic acid dehydratase BMD_4670 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BMD_4672 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BMD_4674 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BMD_4675 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BMD_4676 ENOG4108IUQ atp-dependent protease BMD_4677 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BMD_4678 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BMD_4680 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BMD_4681 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BMD_4683 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BMD_4684 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BMD_4685 ENOG4108ZP8 Acetolactate synthase small subunit BMD_4686 ENOG4105C7K acetolactate synthase BMD_4688 ENOG4105M59 Phosphodiesterase, mj0936 family BMD_4691 ENOG4108XJQ germination protein BMD_4692 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BMD_4693 ENOG41067TZ transcriptional regulator, MarR family BMD_4694 ENOG4108QCI YvbH-like oligomerisation region BMD_4695 ENOG4105CJ3 phosphate transporter BMD_4696 ENOG4107GRR phosphate transport regulator BMD_4697 ENOG4107RVG penicillin-binding protein BMD_4699 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BMD_4700 ENOG4108UZX fmn reductase BMD_4701 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BMD_4702 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BMD_4703 ENOG4105E2Y ABC, transporter BMD_4704 ENOG4107S91 Sodium hydrogen exchanger BMD_4705 ENOG4105NCW Trka-c domain protein BMD_4707 ENOG4105PFC Transcriptional regulator BMD_4709 ENOG4105E33 succinate dehydrogenase BMD_4711 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BMD_4713 ENOG4105CFH Aspartokinase BMD_4715 ENOG4105K63 Thioredoxin BMD_4716 ENOG4105C10 Electron transfer flavoprotein BMD_4717 ENOG4105BZJ Electron transfer flavoprotein BMD_4718 ENOG41060WC Enoyl-CoA hydratase BMD_4719 ENOG4107Z3H Transcriptional regulator, TetR family BMD_4720 ENOG4105CEY Amp-dependent synthetase and ligase BMD_4723 ENOG4105C98 muts2 protein BMD_4724 ENOG4105DCG PHP domain protein BMD_4726 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BMD_4727 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BMD_4728 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BMD_4729 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BMD_4730 ENOG4108RWN rrna methyltransferase BMD_4731 ENOG41067MF small acid-soluble spore protein BMD_4732 ENOG4105CN9 Peptidase m42 family protein BMD_4736 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BMD_4737 ENOG4105VJV 50s ribosomal protein L35 BMD_4738 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BMD_4739 ENOG4105C22 threonyL-tRNA synthetase BMD_4740 ENOG4108TDW sporulation protein YtxC BMD_4743 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BMD_4745 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BMD_4746 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BMD_4747 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BMD_4749 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BMD_4750 ENOG4105C2M dna polymerase I BMD_4751 ENOG4105BZU Histidine kinase BMD_4752 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BMD_4754 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BMD_4755 ENOG4108HMX isocitrate dehydrogenase (NADP) BMD_4756 ENOG4105BZN citrate synthase BMD_4757 ENOG4107CWS Protein of unknown function (DUF441) BMD_4758 ENOG4108REF Sporulation integral membrane protein ytvi BMD_4759 ENOG4105FS0 cytoplasmic membrane protein BMD_4760 ENOG4105CA9 Pyruvate kinase BMD_4761 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BMD_4762 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BMD_4763 ENOG4107YCY Transcriptional regulator BMD_4764 ENOG4105C6K Malic enzyme BMD_4765 ENOG4105C0B DNA polymerase III (alpha subunit) BMD_4766 ENOG4105VV2 BMD_4768 ENOG4105SFS phosphoesterase RecJ domain protein BMD_4772 ENOG4105E8R UPF0173 metal-dependent hydrolase BMD_4775 ENOG4105CH7 arginosuccinase BMD_4776 ENOG4105CDH Citrulline--aspartate ligase BMD_4779 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BMD_4781 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BMD_4782 ENOG4105KBJ sporulation protein ytfj BMD_4784 ENOG4105VK3 rdd domain containing protein BMD_4785 ENOG4105D07 Signal peptide peptidase, SppA BMD_4786 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BMD_4787 ENOG4105EFZ amidohydrolase BMD_4789 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BMD_4791 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) BMD_4792 ENOG4108W76 histidinol phosphate phosphatase hisj family BMD_4793 ENOG4105U5Y Transcriptional regulator BMD_4796 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BMD_4797 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BMD_4799 ENOG4105F1V Acetoin utilization protein BMD_4800 ENOG4105W87 Cbs domain BMD_4801 ENOG4105DGU Histone deacetylase BMD_4802 ENOG4106VK6 Flagellar motor protein BMD_4803 ENOG4105E14 MotA TolQ exbB proton channel BMD_4804 ENOG4105ETE Transcriptional regulator (LacI family BMD_4805 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BMD_4810 ENOG4105DFU Cell wall formation (By similarity) BMD_4813 ENOG4108VDD TRNA binding domain protein BMD_4814 ENOG4108NKM UPF0354 protein BMD_4816 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BMD_4819 ENOG4105C8F Beta-lactamase domain protein BMD_4820 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BMD_4822 ENOG4108V15 phosphotransferase enzyme family BMD_4823 ENOG4108IUM Glycogen debranching enzyme BMD_4825 ENOG4107F58 2'-5' rna ligase BMD_4826 ENOG4105C6T cysteine synthase BMD_4827 ENOG4107QSE Dipeptidase BMD_4828 ENOG4105YW5 deoR family transcriptional regulator BMD_4831 ENOG4105CBX hi0933 family BMD_4833 ENOG41085GJ domain protein BMD_4834 ENOG4105C8T Leucyl-tRNA synthetase BMD_4836 ENOG4105CY2 Citrate transporter BMD_4837 ENOG410605W Major Facilitator BMD_4840 ENOG4105N5T Radical SAM Protein BMD_4843 ENOG4105E8V Alpha Beta Hydrolase Fold protein BMD_4844 ENOG4108Z0R Transferase BMD_4845 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BMD_4846 ENOG4105BZF Glycosyl transferase (Group 1 BMD_4847 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BMD_4848 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BMD_4851 ENOG4105D2X ABC transporter substrate-binding protein BMD_4853 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BMD_4857 ENOG4108RMU ferritin dps family protein BMD_4858 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BMD_4859 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BMD_4860 ENOG4108V2W Carbonate dehydratase BMD_4861 ENOG4105CKI cobalamin synthesis protein BMD_4863 ENOG4105NRA 50s ribosomal protein l31 type b BMD_4866 ENOG4105NQC Flavodoxin BMD_4871 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BMD_4872 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BMD_4873 ENOG4105DTQ mandelate racemase muconate lactonizing BMD_4874 ENOG4105CEY Amp-dependent synthetase and ligase BMD_4875 ENOG4108IPT Naphthoate synthase BMD_4876 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BMD_4877 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BMD_4878 ENOG4105E4F Isochorismate synthase BMD_4882 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BMD_4884 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BMD_4910 ENOG4105CEY Amp-dependent synthetase and ligase BMD_4911 ENOG4105KT7 mgtC SapB transporter BMD_4912 ENOG4108Z73 Siroheme synthase BMD_4913 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BMD_4914 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BMD_4915 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BMD_4921 ENOG4107PBV potassium channel BMD_4923 ENOG4107QYV phosphohexose isomerase BMD_4924 ENOG4105D65 subunit l BMD_4925 ENOG4105HC0 Na H antiporter BMD_4926 ENOG4108ZE9 Monovalent cation H antiporter subunit C BMD_4927 ENOG4108JPZ Monovalent cation H antiporter subunit D BMD_4928 ENOG4105SC1 monovalent cation H antiporter subunit E BMD_4930 ENOG4105KJM monovalent cation h antiporter subunit g BMD_4931 ENOG4107QW4 alcohol dehydrogenase BMD_4932 ENOG4105WG9 Conserved Protein BMD_4934 ENOG4105CHM Aminotransferase BMD_4935 ENOG4108ZB6 transcriptional regulator AsnC family BMD_4936 ENOG4108MUZ hydrolase BMD_4937 ENOG4105C87 Aminotransferase class I and II BMD_4938 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BMD_4940 ENOG4105Y38 Kinase-associated protein B BMD_4942 ENOG4105KA0 thioesterase Superfamily protein BMD_4947 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BMD_4949 ENOG41069ER domain protein BMD_4951 ENOG4105CEP NADH dehydrogenase BMD_4954 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BMD_4956 ENOG4105ZKE UPF0349 protein BMD_4959 ENOG41083MR nifu domain-containing protein BMD_4960 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BMD_4961 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BMD_4962 ENOG4105D6E homoserine dehydrogenase BMD_4963 ENOG4105C5I Dehydrogenase BMD_4965 ENOG4108W5N phosphatidylglycerophosphatase a BMD_4966 ENOG4105D4U had-superfamily hydrolase, subfamily iia BMD_4969 ENOG4105MMD transcriptional regulator BMD_4970 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BMD_4971 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BMD_4972 ENOG4105FAA peptidase M23 BMD_4973 ENOG4108YTE sporulation protein YunB BMD_4974 ENOG4105KZD Domain of unknown function (DUF1805) BMD_4975 ENOG4105I3N Conserved Protein BMD_4976 ENOG4105DIW FeS assembly protein SUFB BMD_4977 ENOG4108UNV SUF system FeS assembly protein, NifU family BMD_4978 ENOG4105C9B Cysteine desulfurase BMD_4979 ENOG4105JRK feS assembly protein SufD BMD_4980 ENOG4105C3K feS assembly ATPase SufC BMD_4982 ENOG4105D01 (LipO)protein BMD_4983 ENOG4108UMI ABC transporter, permease BMD_4984 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BMD_4988 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BMD_4989 ENOG41080E8 Transcriptional regulator, Spx MgsR family BMD_4990 ENOG4105C1G acyl-Coa dehydrogenase BMD_4991 ENOG4105CHU acetyl-coa acetyltransferase BMD_4997 ENOG4105E0A ABC, transporter BMD_4998 ENOG4108IHU transport system permease protein BMD_4999 ENOG4105DQ5 transport system permease protein BMD_5000 ENOG4108MES Periplasmic binding protein BMD_5003 ENOG41067SE Tetr family transcriptional regulator BMD_5005 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BMD_5006 ENOG41079KZ Major Facilitator Superfamily BMD_5007 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BMD_5008 ENOG4105CMU LysR family (Transcriptional regulator BMD_5011 ENOG41062D9 Histidine kinase BMD_5012 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMD_5014 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BMD_5015 ENOG4105FS7 Transcriptional regulator BMD_5016 ENOG4108TVJ Nitroreductase BMD_5017 ENOG41067WU Molybdopterin converting factor (Subunit 1) BMD_5018 ENOG4108ZAF Molybdopterin BMD_5019 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BMD_5020 ENOG4105CVM Molybdenum cofactor synthesis domain protein BMD_5021 ENOG4105D06 uba thif-type nad fad binding protein BMD_5022 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BMD_5024 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BMD_5025 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BMD_5026 ENOG4108JB9 formate dehydrogenase BMD_5028 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BMD_5029 ENOG4105E0C molybdate abc transporter BMD_5030 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BMD_5031 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BMD_5033 ENOG4105XZU Preprotein translocase, subunit SecG BMD_5041 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMD_5044 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BMD_5045 ENOG4105KRI phosphocarrier protein (HPr BMD_5047 ENOG4105CHW UPF0052 protein BMD_5048 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BMD_5049 ENOG4108Z4K mutator MutT protein BMD_5050 ENOG4105C3M thioredoxin reductase BMD_5052 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BMD_5053 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BMD_5054 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BMD_5055 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BMD_5056 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BMD_5057 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BMD_5058 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BMD_5059 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BMD_5060 ENOG4108S4C acetyltransferase BMD_5061 ENOG4107XGZ Hydrolase BMD_5062 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BMD_5063 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BMD_5064 ENOG41086DT Membrane protein of unknown function BMD_5065 ENOG41067S9 phage shock protein C, PspC BMD_5066 ENOG4108PY7 BMD_5068 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BMD_5069 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BMD_5070 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BMD_5074 ENOG4105CN1 protease BMD_5076 ENOG4105CRP Part of the ABC transporter FtsEX involved in BMD_5077 ENOG4105CAK Cell division ATP-binding protein ftsE BMD_5078 ENOG4108WS4 fmn reductase BMD_5080 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BMD_5081 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BMD_5082 ENOG4105DGI Alkaline phosphatase BMD_5083 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BMD_5084 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BMD_5085 ENOG4105SUU thioesterase domain BMD_5086 ENOG4105MS2 ribosomal subunit Interface protein BMD_5088 ENOG4105MQ3 flagellar protein FliS BMD_5089 ENOG4107RT6 flagellar hook-associated BMD_5091 ENOG4105C85 amino acid BMD_5093 ENOG4105C26 Dehydrogenase BMD_5094 ENOG4108JB8 alcohol dehydrogenase BMD_5095 ENOG4105TRT Transcriptional regulator BMD_5096 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BMD_5097 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BMD_5098 ENOG4105DTJ flagellar hook-associated protein BMD_5099 ENOG4105E1Q flagellar hook-associated protein BMD_5103 ENOG41081UC Inherit from COG: Competence protein BMD_5106 ENOG4105XVJ Protein of unknown function (DUF327) BMD_5108 ENOG4105WH1 Two component transcriptional regulator luxr family BMD_5109 ENOG4105BZU Histidine kinase BMD_5110 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BMD_5111 ENOG4108KGH TRANSCRIPTIONal BMD_5112 ENOG4105ESV Glycosyl transferase, family 4 BMD_5114 ENOG4105DZ6 Band 7 protein BMD_5117 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BMD_5119 ENOG4105C0D helicase BMD_5121 ENOG4105Z8H single-stranded DNA-binding protein BMD_5124 ENOG4105CGA flagellar basal-body rod protein FlgG BMD_5126 ENOG4105DFF Rod shape-determining protein mreb BMD_5127 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BMD_5128 ENOG4105FRN stage II sporulation protein BMD_5132 ENOG4106778 Protein of unknown function (DUF1146) BMD_5133 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BMD_5134 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BMD_5135 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BMD_5136 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BMD_5137 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BMD_5138 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) BMD_5139 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BMD_5140 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BMD_5141 ENOG41062M3 atp synthase BMD_5143 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BMD_5144 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BMD_5145 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BMD_5148 ENOG4108YZG isomerase BMD_5151 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BMD_5153 ENOG4108ZXQ stage ii sporulation protein r BMD_5154 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BMD_5155 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BMD_5157 ENOG4105VFB Binds the 23S rRNA (By similarity) BMD_5158 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BMD_5159 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BMD_5160 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BMD_5161 ENOG4105D2N Aldolase BMD_5162 ENOG410812K response regulator receiver protein BMD_5164 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BMD_5166 ENOG4105D5P Methylmalonyl-coA mutase BMD_5168 ENOG4105C1G acyl-Coa dehydrogenase BMD_5169 ENOG4105C1G acyl-Coa dehydrogenase BMD_5170 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BMD_5172 ENOG4105DF6 Fe-S oxidoreductase BMD_5175 ENOG4105C75 arginyL-tRNA synthetase BMD_5176 ENOG410684U Domain of unknown function (DUF1934) BMD_5177 ENOG4105CYW agmatinase BMD_5178 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BMD_5179 ENOG4105BZ4 penicillin-binding protein BMD_5180 ENOG4108XFG YwhD family BMD_5181 ENOG4108Z4T Peptidase M50 BMD_5182 ENOG41069HH 4-oxalocrotonate tautomerase BMD_5184 ENOG4105DCI Phosphohydrolase BMD_5186 ENOG4108VCI transcription factor, rsfa family BMD_5188 ENOG4108IJ2 phosphate acetyltransferase BMD_5189 ENOG4107JTW chlorite dismutase BMD_5190 ENOG4108VKI Cell wall hydrolase BMD_5194 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BMD_5196 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BMD_5197 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BMD_5198 ENOG4108K8K Transcriptional regulator BMD_5199 ENOG4105DCF alanine dehydrogenase BMD_5201 ENOG4105DWF phosphomethylpyrimidine kinase BMD_5202 ENOG4105J7I hydrolase BMD_5203 ENOG4107URF beta-phospho-glucomutase BMD_5204 ENOG4105CI1 PTS System BMD_5206 ENOG4105CPK Glycosyl transferase (Group 1 BMD_5207 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 BMD_5209 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BMD_5211 ENOG4105CJR Integral membrane protein (MviN BMD_5214 ENOG4108JJ8 (ABC) transporter BMD_5215 ENOG4108JJ9 ABC, transporter BMD_5216 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BMD_5217 ENOG4105C4M (Ubiquinol oxidase) subunit I BMD_5218 ENOG4107XM3 UPF0442 protein BMD_5219 ENOG4105DWK Membrane BMD_5220 ENOG4105ETE Transcriptional regulator (LacI family BMD_5227 ENOG4105BZU Histidine kinase BMD_5230 ENOG4107QPK )-transporter BMD_5231 ENOG4105DR4 Methyltransferase BMD_5234 ENOG4105BZU Histidine kinase BMD_5238 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BMD_5240 ENOG4105C0H protease BMD_5241 ENOG4105Q2H domain protein BMD_5244 ENOG4105BZU Histidine kinase BMD_5245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMD_5250 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BMD_5251 ENOG4105CDU Replicative dna helicase BMD_5253 ENOG4105BZR domain protein BMD_5255 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BMD_5256 ENOG4108UUM single-stranded DNA-binding protein BMD_5258 ENOG4105C3G gtp-binding protein BMD_5259 ENOG4105VDK protein, conserved in bacteria BMD_5260 ENOG4105D8X mechanosensitive ion channel BMD_5262 ENOG4108ZDA Sporulation protein YyaC BMD_5263 ENOG4105FA0 parb-like partition protein BMD_5264 ENOG4107QJE Chromosome Partitioning Protein BMD_5265 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) BMD_5267 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BMD_5268 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BMD_5270 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BMD_5271 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BMD_5272 ENOG4105VG0 50S ribosomal protein l34