locus-tag class description FDZ14_00030 ENOG4108IND Tetr family transcriptional regulator FDZ14_00035 ENOG4105E1F short-chain dehydrogenase reductase FDZ14_00045 ENOG4105N14 lysine exporter protein LysE YggA FDZ14_00080 ENOG41067QW Transcriptional regulator FDZ14_00090 ENOG4105DC1 bifunctional purine biosynthesis protein purh FDZ14_00140 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FDZ14_00170 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FDZ14_00175 ENOG4105DY9 regulatoR FDZ14_00195 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FDZ14_00275 ENOG4105GR3 Histidine kinase FDZ14_00380 ENOG4105H67 Protein of unknown function (DUF421) FDZ14_00395 ENOG4105K4H Nlp p60 protein FDZ14_00455 ENOG4107QJE Chromosome Partitioning Protein FDZ14_00475 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FDZ14_00530 ENOG4107RZZ dna polymerase iii epsilon subunit FDZ14_00685 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FDZ14_00690 ENOG4105VG0 50S ribosomal protein l34 FDZ14_00695 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FDZ14_00700 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FDZ14_00710 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FDZ14_00715 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FDZ14_00725 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) FDZ14_00730 ENOG4107QJE Chromosome Partitioning Protein FDZ14_00735 ENOG4105FA0 parb-like partition protein FDZ14_00740 ENOG4108ZDA Sporulation protein YyaC FDZ14_00750 ENOG4105D8X mechanosensitive ion channel FDZ14_00755 ENOG4105VDK protein, conserved in bacteria FDZ14_00760 ENOG4105C3G gtp-binding protein FDZ14_00770 ENOG4108UUM single-stranded DNA-binding protein FDZ14_00775 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FDZ14_00785 ENOG4105BZR domain protein FDZ14_00795 ENOG4105CDU Replicative dna helicase FDZ14_00800 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FDZ14_00825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDZ14_00830 ENOG4105BZU Histidine kinase FDZ14_00845 ENOG4105Q2H domain protein FDZ14_00850 ENOG4105C0H protease FDZ14_00860 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FDZ14_00880 ENOG4105BZU Histidine kinase FDZ14_00895 ENOG4105DR4 Methyltransferase FDZ14_00900 ENOG4107QPK )-transporter FDZ14_00915 ENOG4105BZU Histidine kinase FDZ14_00950 ENOG4105ETE Transcriptional regulator (LacI family FDZ14_00955 ENOG4105DWK Membrane FDZ14_00960 ENOG4107XM3 UPF0442 protein FDZ14_00965 ENOG4105C4M (Ubiquinol oxidase) subunit I FDZ14_00970 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FDZ14_00975 ENOG4108JJ9 ABC, transporter FDZ14_00980 ENOG4108JJ8 (ABC) transporter FDZ14_00995 ENOG4105CJR Integral membrane protein (MviN FDZ14_01005 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FDZ14_01015 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 FDZ14_01020 ENOG4105CPK Glycosyl transferase (Group 1 FDZ14_01030 ENOG4105CI1 PTS System FDZ14_01035 ENOG4107URF beta-phospho-glucomutase FDZ14_01040 ENOG4105J7I hydrolase FDZ14_01045 ENOG4105DWF phosphomethylpyrimidine kinase FDZ14_01055 ENOG4105DCF alanine dehydrogenase FDZ14_01060 ENOG4108K8K Transcriptional regulator FDZ14_01065 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FDZ14_01070 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FDZ14_01080 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FDZ14_01100 ENOG4108VKI Cell wall hydrolase FDZ14_01105 ENOG4107JTW chlorite dismutase FDZ14_01110 ENOG4108IJ2 phosphate acetyltransferase FDZ14_01120 ENOG4108VCI transcription factor, rsfa family FDZ14_01130 ENOG4105DCI Phosphohydrolase FDZ14_01140 ENOG41069HH 4-oxalocrotonate tautomerase FDZ14_01145 ENOG4108Z4T Peptidase M50 FDZ14_01150 ENOG4108XFG YwhD family FDZ14_01160 ENOG4105BZ4 penicillin-binding protein FDZ14_01165 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FDZ14_01170 ENOG4105CYW agmatinase FDZ14_01175 ENOG410684U Domain of unknown function (DUF1934) FDZ14_01180 ENOG4105C75 arginyL-tRNA synthetase FDZ14_01195 ENOG4105DF6 Fe-S oxidoreductase FDZ14_01205 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FDZ14_01210 ENOG4105C1G acyl-Coa dehydrogenase FDZ14_01215 ENOG4105C1G acyl-Coa dehydrogenase FDZ14_01225 ENOG4105D5P Methylmalonyl-coA mutase FDZ14_01235 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FDZ14_01245 ENOG410812K response regulator receiver protein FDZ14_01250 ENOG4105D2N Aldolase FDZ14_01255 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FDZ14_01260 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FDZ14_01265 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FDZ14_01270 ENOG4105VFB Binds the 23S rRNA (By similarity) FDZ14_01280 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FDZ14_01285 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FDZ14_01290 ENOG4108ZXQ stage ii sporulation protein r FDZ14_01300 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FDZ14_01315 ENOG4108YZG isomerase FDZ14_01330 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FDZ14_01335 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FDZ14_01340 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FDZ14_01350 ENOG41062M3 atp synthase FDZ14_01355 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FDZ14_01360 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FDZ14_01365 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FDZ14_01370 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FDZ14_01375 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FDZ14_01380 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FDZ14_01385 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FDZ14_01390 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FDZ14_01395 ENOG4106778 Protein of unknown function (DUF1146) FDZ14_01415 ENOG4105FRN stage II sporulation protein FDZ14_01420 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FDZ14_01425 ENOG4105DFF Rod shape-determining protein mreb FDZ14_01435 ENOG4105CGA flagellar basal-body rod protein FlgG FDZ14_01455 ENOG4105Z8H single-stranded DNA-binding protein FDZ14_01465 ENOG4105C0D helicase FDZ14_01475 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FDZ14_01490 ENOG4105DZ6 Band 7 protein FDZ14_01500 ENOG4105ESV Glycosyl transferase, family 4 FDZ14_01505 ENOG4108KGH TRANSCRIPTIONal FDZ14_01510 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FDZ14_01515 ENOG4105BZU Histidine kinase FDZ14_01520 ENOG4105WH1 Two component transcriptional regulator luxr family FDZ14_01530 ENOG4105XVJ Protein of unknown function (DUF327) FDZ14_01545 ENOG41081UC Inherit from COG: Competence protein FDZ14_01565 ENOG4105E1Q flagellar hook-associated protein FDZ14_01570 ENOG4105DTJ flagellar hook-associated protein FDZ14_01575 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) FDZ14_01580 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FDZ14_01585 ENOG4105TRT Transcriptional regulator FDZ14_01590 ENOG4108JB8 alcohol dehydrogenase FDZ14_01605 ENOG4105C85 amino acid FDZ14_01615 ENOG4107RT6 flagellar hook-associated FDZ14_01620 ENOG4105MQ3 flagellar protein FliS FDZ14_01630 ENOG4105MS2 ribosomal subunit Interface protein FDZ14_01635 ENOG4105SUU thioesterase domain FDZ14_01640 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FDZ14_01650 ENOG4105DGI Alkaline phosphatase FDZ14_01655 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FDZ14_01660 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FDZ14_01670 ENOG4108WS4 fmn reductase FDZ14_01675 ENOG4105CAK Cell division ATP-binding protein ftsE FDZ14_01680 ENOG4105CRP Part of the ABC transporter FtsEX involved in FDZ14_01685 ENOG4105DR5 peptidase FDZ14_01690 ENOG4105CN1 protease FDZ14_01710 ENOG4105C26 Dehydrogenase FDZ14_01715 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDZ14_01720 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FDZ14_01725 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FDZ14_01735 ENOG4108PY7 FDZ14_01745 ENOG41086DT Membrane protein of unknown function FDZ14_01750 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FDZ14_01755 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FDZ14_01760 ENOG4107XGZ Hydrolase FDZ14_01765 ENOG4108S4C acetyltransferase FDZ14_01770 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FDZ14_01775 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FDZ14_01780 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FDZ14_01785 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FDZ14_01790 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FDZ14_01795 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FDZ14_01800 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FDZ14_01805 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FDZ14_01815 ENOG4105C3M thioredoxin reductase FDZ14_01820 ENOG4108Z4K mutator MutT protein FDZ14_01825 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FDZ14_01830 ENOG4105CHW UPF0052 protein FDZ14_01840 ENOG4105KRI phosphocarrier protein (HPr FDZ14_01860 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDZ14_01900 ENOG4105XZU Preprotein translocase, subunit SecG FDZ14_01910 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FDZ14_01915 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FDZ14_01925 ENOG4105E0C molybdate abc transporter FDZ14_01930 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FDZ14_01940 ENOG4108JB9 formate dehydrogenase FDZ14_01945 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FDZ14_01950 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FDZ14_01960 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FDZ14_01965 ENOG4105D06 uba thif-type nad fad binding protein FDZ14_01970 ENOG4105CVM Molybdenum cofactor synthesis domain protein FDZ14_01975 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FDZ14_01980 ENOG4108ZAF Molybdopterin FDZ14_01985 ENOG41067WU Molybdopterin converting factor (Subunit 1) FDZ14_01990 ENOG4108TVJ Nitroreductase FDZ14_01995 ENOG4105FS7 Transcriptional regulator FDZ14_02005 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FDZ14_02015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDZ14_02020 ENOG41062D9 Histidine kinase FDZ14_02030 ENOG4105CMU LysR family (Transcriptional regulator FDZ14_02035 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FDZ14_02040 ENOG41079KZ Major Facilitator Superfamily FDZ14_02045 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FDZ14_02055 ENOG41067SE Tetr family transcriptional regulator FDZ14_02070 ENOG4108MES Periplasmic binding protein FDZ14_02075 ENOG4105DQ5 transport system permease protein FDZ14_02080 ENOG4108IHU transport system permease protein FDZ14_02085 ENOG4105E0A ABC, transporter FDZ14_02115 ENOG4105CHU acetyl-coa acetyltransferase FDZ14_02120 ENOG4105C1G acyl-Coa dehydrogenase FDZ14_02125 ENOG41080E8 Transcriptional regulator, Spx MgsR family FDZ14_02130 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FDZ14_02150 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FDZ14_02155 ENOG4108UMI ABC transporter, permease FDZ14_02160 ENOG4105D01 (LipO)protein FDZ14_02170 ENOG4105C3K feS assembly ATPase SufC FDZ14_02175 ENOG4105JRK feS assembly protein SufD FDZ14_02180 ENOG4105C9B Cysteine desulfurase FDZ14_02185 ENOG4108UNV SUF system FeS assembly protein, NifU family FDZ14_02190 ENOG4105DIW FeS assembly protein SUFB FDZ14_02195 ENOG4105I3N Conserved Protein FDZ14_02200 ENOG4105KZD Domain of unknown function (DUF1805) FDZ14_02205 ENOG4108YTE sporulation protein YunB FDZ14_02210 ENOG4105C8J )-transporter FDZ14_02220 ENOG4105FAA peptidase M23 FDZ14_02225 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FDZ14_02230 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FDZ14_02235 ENOG4105MMD transcriptional regulator FDZ14_02250 ENOG4105D4U had-superfamily hydrolase, subfamily iia FDZ14_02255 ENOG4108W5N phosphatidylglycerophosphatase a FDZ14_02265 ENOG4105C5I Dehydrogenase FDZ14_02270 ENOG4105D6E homoserine dehydrogenase FDZ14_02275 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FDZ14_02280 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FDZ14_02285 ENOG41083MR nifu domain-containing protein FDZ14_02300 ENOG4105ZKE UPF0349 protein FDZ14_02305 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FDZ14_02310 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FDZ14_02325 ENOG4105CEP NADH dehydrogenase FDZ14_02335 ENOG41069ER domain protein FDZ14_02345 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FDZ14_02370 ENOG4105KA0 thioesterase Superfamily protein FDZ14_02380 ENOG4105Y38 Kinase-associated protein B FDZ14_02390 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FDZ14_02395 ENOG4105C87 Aminotransferase class I and II FDZ14_02400 ENOG4108MUZ hydrolase FDZ14_02405 ENOG4108ZB6 transcriptional regulator AsnC family FDZ14_02410 ENOG4105CHM Aminotransferase FDZ14_02420 ENOG4105WG9 Conserved Protein FDZ14_02425 ENOG4107QW4 alcohol dehydrogenase FDZ14_02430 ENOG4105KJM monovalent cation h antiporter subunit g FDZ14_02440 ENOG4105SC1 monovalent cation H antiporter subunit E FDZ14_02445 ENOG4108JPZ Monovalent cation H antiporter subunit D FDZ14_02450 ENOG4108ZE9 Monovalent cation H antiporter subunit C FDZ14_02455 ENOG4105HC0 Na H antiporter FDZ14_02460 ENOG4105D65 subunit l FDZ14_02470 ENOG4107QYV phosphohexose isomerase FDZ14_02485 ENOG4107PBV potassium channel FDZ14_02515 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FDZ14_02520 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FDZ14_02525 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FDZ14_02530 ENOG4108Z73 Siroheme synthase FDZ14_02535 ENOG4105KT7 mgtC SapB transporter FDZ14_02540 ENOG4105CEY Amp-dependent synthetase and ligase FDZ14_02680 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FDZ14_02700 ENOG4105E4F Isochorismate synthase FDZ14_02705 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FDZ14_02710 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FDZ14_02715 ENOG4108IPT Naphthoate synthase FDZ14_02720 ENOG4105CEY Amp-dependent synthetase and ligase FDZ14_02725 ENOG4105DTQ mandelate racemase muconate lactonizing FDZ14_02730 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FDZ14_02735 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FDZ14_02760 ENOG4105NQC Flavodoxin FDZ14_02775 ENOG4105NRA 50s ribosomal protein l31 type b FDZ14_02785 ENOG4105CKI cobalamin synthesis protein FDZ14_02790 ENOG4108V2W Carbonate dehydratase FDZ14_02795 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FDZ14_02800 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FDZ14_02805 ENOG4108RMU ferritin dps family protein FDZ14_02825 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FDZ14_02835 ENOG4105D2X ABC transporter substrate-binding protein FDZ14_02850 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FDZ14_02855 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FDZ14_02860 ENOG4105BZF Glycosyl transferase (Group 1 FDZ14_02865 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FDZ14_02870 ENOG4108Z0R Transferase FDZ14_02875 ENOG4105E8V Alpha Beta Hydrolase Fold protein FDZ14_02890 ENOG4105N5T Radical SAM Protein FDZ14_02905 ENOG410605W Major Facilitator FDZ14_02910 ENOG4105CY2 Citrate transporter FDZ14_02920 ENOG4105C8T Leucyl-tRNA synthetase FDZ14_02925 ENOG41085GJ domain protein FDZ14_02940 ENOG4105CBX hi0933 family FDZ14_02955 ENOG4105YW5 deoR family transcriptional regulator FDZ14_02960 ENOG4107QSE Dipeptidase FDZ14_02965 ENOG4105C6T cysteine synthase FDZ14_02970 ENOG4107F58 2'-5' rna ligase FDZ14_02980 ENOG4108IUM Glycogen debranching enzyme FDZ14_02985 ENOG4108V15 phosphotransferase enzyme family FDZ14_02995 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FDZ14_03000 ENOG4105C8F Beta-lactamase domain protein FDZ14_03015 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FDZ14_03025 ENOG4108NKM UPF0354 protein FDZ14_03030 ENOG4108VDD TRNA binding domain protein FDZ14_03045 ENOG4105DFU Cell wall formation (By similarity) FDZ14_03070 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FDZ14_03075 ENOG4105ETE Transcriptional regulator (LacI family FDZ14_03080 ENOG4105E14 MotA TolQ exbB proton channel FDZ14_03085 ENOG4106VK6 Flagellar motor protein FDZ14_03090 ENOG4105DGU Histone deacetylase FDZ14_03095 ENOG4105W87 Cbs domain FDZ14_03100 ENOG4105F1V Acetoin utilization protein FDZ14_03115 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FDZ14_03125 ENOG4105U5Y Transcriptional regulator FDZ14_03130 ENOG4108W76 histidinol phosphate phosphatase hisj family FDZ14_03135 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) FDZ14_03145 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FDZ14_03155 ENOG4105EFZ amidohydrolase FDZ14_03160 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FDZ14_03165 ENOG4105D07 Signal peptide peptidase, SppA FDZ14_03170 ENOG4105VK3 rdd domain containing protein FDZ14_03180 ENOG4105KBJ sporulation protein ytfj FDZ14_03185 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FDZ14_03195 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FDZ14_03210 ENOG4105CDH Citrulline--aspartate ligase FDZ14_03215 ENOG4105CH7 arginosuccinase FDZ14_03225 ENOG4105E8R UPF0173 metal-dependent hydrolase FDZ14_03245 ENOG4105SFS phosphoesterase RecJ domain protein FDZ14_03255 ENOG4105VV2 FDZ14_03260 ENOG4105C0B DNA polymerase III (alpha subunit) FDZ14_03265 ENOG4105C6K Malic enzyme FDZ14_03270 ENOG4107YCY Transcriptional regulator FDZ14_03275 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FDZ14_03280 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FDZ14_03285 ENOG4105CA9 Pyruvate kinase FDZ14_03290 ENOG4105FS0 cytoplasmic membrane protein FDZ14_03295 ENOG4108REF Sporulation integral membrane protein ytvi FDZ14_03300 ENOG4107CWS Protein of unknown function (DUF441) FDZ14_03305 ENOG4105BZN citrate synthase FDZ14_03310 ENOG4108HMX isocitrate dehydrogenase (NADP) FDZ14_03315 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FDZ14_03325 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FDZ14_03330 ENOG4105BZU Histidine kinase FDZ14_03335 ENOG4105C2M dna polymerase I FDZ14_03340 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FDZ14_03355 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FDZ14_03360 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FDZ14_03370 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FDZ14_03385 ENOG4108TDW sporulation protein YtxC FDZ14_03390 ENOG4105C22 threonyL-tRNA synthetase FDZ14_03395 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FDZ14_03400 ENOG4105VJV 50s ribosomal protein L35 FDZ14_03405 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FDZ14_03425 ENOG4105CN9 Peptidase m42 family protein FDZ14_03430 ENOG41067MF small acid-soluble spore protein FDZ14_03435 ENOG4108RWN rrna methyltransferase FDZ14_03445 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FDZ14_03450 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FDZ14_03455 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FDZ14_03465 ENOG4105DCG PHP domain protein FDZ14_03470 ENOG4105C98 muts2 protein FDZ14_03485 ENOG4105CEY Amp-dependent synthetase and ligase FDZ14_03490 ENOG4107Z3H Transcriptional regulator, TetR family FDZ14_03495 ENOG41060WC Enoyl-CoA hydratase FDZ14_03500 ENOG4105BZJ Electron transfer flavoprotein FDZ14_03505 ENOG4105C10 Electron transfer flavoprotein FDZ14_03510 ENOG4105K63 Thioredoxin FDZ14_03520 ENOG4105CFH Aspartokinase FDZ14_03530 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FDZ14_03540 ENOG4105E33 succinate dehydrogenase FDZ14_03550 ENOG4105PFC Transcriptional regulator FDZ14_03560 ENOG4105NCW Trka-c domain protein FDZ14_03565 ENOG4107S91 Sodium hydrogen exchanger FDZ14_03570 ENOG4105E2Y ABC, transporter FDZ14_03575 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FDZ14_03580 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FDZ14_03585 ENOG4108UZX fmn reductase FDZ14_03590 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FDZ14_03600 ENOG4107RVG penicillin-binding protein FDZ14_03605 ENOG4107GRR phosphate transport regulator FDZ14_03610 ENOG4105CJ3 phosphate transporter FDZ14_03615 ENOG4108QCI YvbH-like oligomerisation region FDZ14_03620 ENOG41067TZ transcriptional regulator, MarR family FDZ14_03625 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FDZ14_03630 ENOG4108XJQ germination protein FDZ14_03645 ENOG4105M59 Phosphodiesterase, mj0936 family FDZ14_03655 ENOG4105C7K acetolactate synthase FDZ14_03660 ENOG4108ZP8 Acetolactate synthase small subunit FDZ14_03665 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FDZ14_03670 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FDZ14_03680 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FDZ14_03685 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FDZ14_03695 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FDZ14_03700 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FDZ14_03705 ENOG4108IUQ atp-dependent protease FDZ14_03710 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FDZ14_03715 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FDZ14_03725 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FDZ14_03735 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FDZ14_03745 ENOG4105D52 delta-aminolevulinic acid dehydratase FDZ14_03750 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FDZ14_03755 ENOG41068KH stage VI sporulation protein D FDZ14_03760 ENOG4106AR7 Spore coat protein FDZ14_03770 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FDZ14_03775 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FDZ14_03780 ENOG4108SJC Membrane FDZ14_03790 ENOG4106A3R peptidase FDZ14_03800 ENOG4108Z03 MAF-like protein FDZ14_03805 ENOG4105W5Q DNA repair protein (RadC FDZ14_03810 ENOG4105DFF Rod shape-determining protein mreb FDZ14_03815 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FDZ14_03820 ENOG4105YHC Rod shape-determining protein MreD FDZ14_03825 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FDZ14_03830 ENOG4107QMS site-determining protein FDZ14_03845 ENOG4105C03 ribonuclease FDZ14_03855 ENOG4105X36 (ribosomal) protein FDZ14_03860 ENOG4105K46 50S ribosomal protein l27 FDZ14_03870 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FDZ14_03875 ENOG41090I5 UPF0735 ACT domain-containing protein FDZ14_03880 ENOG4105CQC Prephenate dehydratase FDZ14_03895 ENOG4108IYU L-aspartate oxidase FDZ14_03900 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FDZ14_03905 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FDZ14_03910 ENOG4106678 morphogenetic protein associated with SpoVID FDZ14_03940 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FDZ14_03945 ENOG41061AI Protein of unknown function (DUF2905) FDZ14_03950 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FDZ14_03960 ENOG4105VIE preprotein translocase, subunit YajC FDZ14_03965 ENOG4105NAP FDZ14_03970 ENOG4108QG2 Membrane FDZ14_03975 ENOG4105CKP Polysaccharide Biosynthesis Protein FDZ14_03985 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FDZ14_03990 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FDZ14_03995 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FDZ14_04000 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FDZ14_04005 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FDZ14_04010 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FDZ14_04020 ENOG4105CUT histidyl-tRNA synthetase FDZ14_04025 ENOG4105C9M aspartyl-trna synthetase FDZ14_04035 ENOG4105CUZ uba thif-type nad fad binding protein FDZ14_04040 ENOG4105CVA phosphate FDZ14_04045 ENOG4105C8U phosphate abc transporter FDZ14_04050 ENOG4105E2Z phosphate ABC transporter (Permease FDZ14_04055 ENOG4105D1H recombination factor protein RarA FDZ14_04065 ENOG4105C3J Cysteine desulfurase FDZ14_04070 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FDZ14_04080 ENOG4105C7H Helicase, RecD TraA family FDZ14_04085 ENOG41060CR FDZ14_04095 ENOG4105C02 permease FDZ14_04100 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FDZ14_04105 ENOG4105VBH UPF0297 protein FDZ14_04115 ENOG4105VPH UPF0473 protein FDZ14_04120 ENOG4105HHA aminodeoxychorismate lyase FDZ14_04130 ENOG4105XYU peptidase (U32 family) FDZ14_04135 ENOG4105CFP Peptidase U32 FDZ14_04140 ENOG4105DBI uridine monophosphokinase FDZ14_04145 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FDZ14_04150 ENOG4105D3W isochorismatase FDZ14_04155 ENOG4107XRG penicillin-binding protein FDZ14_04170 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FDZ14_04175 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FDZ14_04185 ENOG4105C28 cystathionine FDZ14_04200 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDZ14_04205 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FDZ14_04210 ENOG4105DJ4 phosphatidylserine decarboxylase FDZ14_04220 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FDZ14_04225 ENOG4105CQW ribosome biogenesis GTPase YqeH FDZ14_04230 ENOG4105E2X shikimate dehydrogenase FDZ14_04235 ENOG410812S Rna-binding protein FDZ14_04240 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FDZ14_04245 ENOG4108WF2 Metal Dependent Phosphohydrolase FDZ14_04250 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FDZ14_04255 ENOG4105DXX methyltransferase FDZ14_04265 ENOG4105KQC Competence protein FDZ14_04270 ENOG4108UK2 deaminase FDZ14_04275 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FDZ14_04285 ENOG4105TQK DNA polymerase iii, delta' subunit FDZ14_04290 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FDZ14_04305 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FDZ14_04310 ENOG4105CSA Coproporphyrinogen iii oxidase FDZ14_04315 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FDZ14_04320 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FDZ14_04330 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FDZ14_04335 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FDZ14_04340 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FDZ14_04345 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FDZ14_04355 ENOG4105KTH gatB Yqey FDZ14_04360 ENOG4105F7J membrane-bound serine protease FDZ14_04375 ENOG41068P3 sporulation protein YqfC FDZ14_04385 ENOG4105C9A Phoh family FDZ14_04390 ENOG4105CTJ Metal Dependent Phosphohydrolase FDZ14_04395 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FDZ14_04400 ENOG4107YR5 Diacylglycerol kinase FDZ14_04405 ENOG4105KG3 cytidine deaminase FDZ14_04410 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FDZ14_04420 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FDZ14_04430 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FDZ14_04435 ENOG4107XJU UPF0178 protein FDZ14_04440 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FDZ14_04445 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDZ14_04450 ENOG4105C1G acyl-Coa dehydrogenase FDZ14_04465 ENOG4105EGD dinuclear metal center protein, YbgI family FDZ14_04470 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FDZ14_04485 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FDZ14_04495 ENOG4105FDK ABC transporter FDZ14_04500 ENOG4105FAV ABC, transporter FDZ14_04505 ENOG4105N80 Ferric uptake regulator, Fur family FDZ14_04510 ENOG4108U5J '-nucleotidase FDZ14_04515 ENOG41063Y9 FDZ14_04520 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FDZ14_04530 ENOG4107RCC Major Facilitator Superfamily FDZ14_04540 ENOG4105SXS Protein of unknown function (DUF456) FDZ14_04580 ENOG4107RF6 penicillin-binding protein FDZ14_04585 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FDZ14_04590 ENOG4108UTW Plays a role in the regulation of phosphate uptake FDZ14_04610 ENOG410861F 50S ribosomal protein L33 FDZ14_04615 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FDZ14_04625 ENOG4107ZXI Rhomboid family FDZ14_04635 ENOG4105DKQ ROK family FDZ14_04650 ENOG4105C5X domain protein FDZ14_04675 ENOG4106855 Competence protein FDZ14_04710 ENOG4105C0D helicase FDZ14_04715 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FDZ14_04720 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FDZ14_04730 ENOG4105WZW rhodanese family FDZ14_04735 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FDZ14_04745 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FDZ14_04750 ENOG4105KST dependent repressor FDZ14_04765 ENOG4105CBJ Metal-dependent enzyme FDZ14_04775 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FDZ14_04780 ENOG4105DC7 peptidase M24 FDZ14_04785 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FDZ14_04795 ENOG4105CD2 stage iii sporulation protein aa FDZ14_04800 ENOG4105KR5 Stage iii sporulation protein FDZ14_04805 ENOG4108CQH stage III sporulation protein AC FDZ14_04810 ENOG4105KQ4 Stage iii sporulation protein ad FDZ14_04820 ENOG410644B Stage III sporulation protein af FDZ14_04840 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FDZ14_04845 ENOG4108ZSR alkaline shock protein FDZ14_04850 ENOG4105M7K Involved in the transcription termination process (By similarity) FDZ14_04860 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FDZ14_04875 ENOG4105DX0 Hemolysin A FDZ14_04885 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FDZ14_04890 ENOG4105S1Z Stage IV sporulation protein B FDZ14_04895 ENOG4107QQR Sporulation FDZ14_04900 ENOG4105DUX Transporter FDZ14_04910 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FDZ14_04915 ENOG4106CCJ Protein of unknown function (DUF2627) FDZ14_04920 ENOG4108JUB Transcriptional regulator FDZ14_04930 ENOG4107RDP Dehydrogenase FDZ14_04950 ENOG4105CPP Dehydrogenase, E1 component FDZ14_04955 ENOG4105C7S Dehydrogenase FDZ14_04965 ENOG4105D5P Methylmalonyl-coA mutase FDZ14_04970 ENOG4105DJT lAO AO transport system ATPase FDZ14_04975 ENOG4108Y6J UPF0403 protein FDZ14_04980 ENOG4108HW3 (ABC) transporter FDZ14_04985 ENOG4105E5Q amino acid AbC transporter FDZ14_04990 ENOG4105CDA abc transporter atp-binding protein FDZ14_04995 ENOG4108QEG Membrane FDZ14_05000 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FDZ14_05015 ENOG4108HNZ carboxyl transferase FDZ14_05020 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FDZ14_05025 ENOG4105BZ8 glutamate synthase FDZ14_05030 ENOG4107SJI Dehydrogenase FDZ14_05050 ENOG4105G9B Transcriptional regulator FDZ14_05055 ENOG4105C26 Dehydrogenase FDZ14_05060 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FDZ14_05065 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FDZ14_05070 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDZ14_05075 ENOG4105II7 pyrroline-5-carboxylate reductase FDZ14_05080 ENOG41069FQ Metallo-beta-lactamase superfamily FDZ14_05085 ENOG4108IXY short-chain dehydrogenase reductase FDZ14_05105 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FDZ14_05110 ENOG4105CHU acetyl-coa acetyltransferase FDZ14_05115 ENOG4105D6N CoA-transferase, subunit a FDZ14_05120 ENOG4108IIH CoA-transferase subunit B FDZ14_05130 ENOG4105CPC Aldo Keto reductase FDZ14_05140 ENOG4108YZ4 nudix hydrolase FDZ14_05145 ENOG4105MZ9 stage II sporulation protein m FDZ14_05150 ENOG4105I3K Ferric uptake regulator, Fur family FDZ14_05160 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FDZ14_05175 ENOG4105DZ1 carboxypeptidase FDZ14_05180 ENOG41082AN stage II sporulation protein FDZ14_05185 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FDZ14_05190 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDZ14_05205 ENOG41090VF Stage v sporulation protein ac FDZ14_05210 ENOG4105CZ3 stage V sporulation protein ad FDZ14_05220 ENOG4105G6R Stage v sporulation protein ae FDZ14_05235 ENOG4105PTM secreted protein FDZ14_05240 ENOG4107ZE5 PPIases accelerate the folding of proteins FDZ14_05260 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FDZ14_05265 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FDZ14_05270 ENOG4105DZ1 carboxypeptidase FDZ14_05275 ENOG4108JIC nucleoside recognition domain protein FDZ14_05285 ENOG4105FE9 pseudouridine synthase FDZ14_05290 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FDZ14_05295 ENOG4107TWT Cytochrome c biogenesis protein FDZ14_05300 ENOG4105CRE cytochrome C FDZ14_05305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDZ14_05310 ENOG4105BZU Histidine kinase FDZ14_05315 ENOG4105DR5 peptidase FDZ14_05320 ENOG4108JQ1 Dehydrogenase FDZ14_05325 ENOG4108SAX Membrane FDZ14_05340 ENOG4105C9U ATP-dependent DNA helicase RecQ FDZ14_05345 ENOG4105I7S Abortive infection protein FDZ14_05360 ENOG4107RGJ metallophosphoesterase FDZ14_05365 ENOG4108XDN Transcriptional regulator FDZ14_05370 ENOG4108S6Z Negative regulator of genetic competence FDZ14_05380 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FDZ14_05385 ENOG4107RB3 L-asparaginase FDZ14_05395 ENOG4105F0V Cell wall hydrolase FDZ14_05400 ENOG4105MSI germination protein ypeb FDZ14_05410 ENOG4105CAT Cytidine monophosphate kinase FDZ14_05415 ENOG4105E9Q Acyl-transferase FDZ14_05420 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FDZ14_05425 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FDZ14_05450 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FDZ14_05465 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FDZ14_05470 ENOG4105K70 DNA-binding protein FDZ14_05475 ENOG4105EUJ GTP cyclohydrolase i FDZ14_05480 ENOG4105WP2 Tryptophan RNA-binding attenuator protein FDZ14_05485 ENOG4105XXQ heptaprenyl diphosphate synthase component I FDZ14_05490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FDZ14_05495 ENOG4105EAH synthase FDZ14_05500 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FDZ14_05505 ENOG4105BZU Histidine kinase FDZ14_05510 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FDZ14_05515 ENOG4105D49 3-dehydroquinate synthase FDZ14_05525 ENOG4108I0Q anthranilate phosphoribosyltransferase FDZ14_05530 ENOG4105DK0 Indole-3-glycerol phosphate synthase FDZ14_05535 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FDZ14_05545 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FDZ14_05550 ENOG4105CIH Imidazole acetol-phosphate transaminase FDZ14_05560 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FDZ14_05565 ENOG41068YB TPR repeat-containing protein FDZ14_05570 ENOG4108SXZ UPF0302 protein FDZ14_05580 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FDZ14_05585 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FDZ14_05590 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FDZ14_05625 ENOG4105WUC UPF0298 protein FDZ14_05635 ENOG4106H78 methyltransferase FDZ14_05640 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FDZ14_05645 ENOG4105H20 Sporulation integral membrane protein YlbJ FDZ14_05650 ENOG4105D78 K07001 NTE family protein FDZ14_05655 ENOG41063PX domain protein FDZ14_05660 ENOG4105CDE UPF0348 protein FDZ14_05665 ENOG4105KNH Nucleic acid-binding protein FDZ14_05670 ENOG41067VY 50S ribosomal protein L32 FDZ14_05675 ENOG4105E39 Enoyl-CoA hydratase FDZ14_05685 ENOG4108YG3 N-acetyltransferase FDZ14_05690 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FDZ14_05695 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FDZ14_05700 ENOG4107QX3 carboxylase FDZ14_05715 ENOG41074B2 UPF0747 protein FDZ14_05725 ENOG41068DC Essential cell division protein (By similarity) FDZ14_05730 ENOG4105CJN penicillin-binding protein FDZ14_05735 ENOG4105CJN penicillin-binding protein FDZ14_05740 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FDZ14_05745 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FDZ14_05750 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FDZ14_05755 ENOG4105CNI cell division protein FtsW FDZ14_05760 ENOG4105D4A Cell wall formation (By similarity) FDZ14_05765 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FDZ14_05770 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FDZ14_05775 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FDZ14_05780 ENOG4108AWX Sporulation factor SpoIIGA FDZ14_05785 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDZ14_05795 ENOG4105WR5 sporulation protein, YlmC YmxH family FDZ14_05800 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FDZ14_05805 ENOG4105DFA alanine racemase domain protein FDZ14_05810 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FDZ14_05815 ENOG41067XK integral membrane protein FDZ14_05820 ENOG4105DBK s4 domain protein FDZ14_05840 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FDZ14_05845 ENOG4105C34 Pseudouridine synthase FDZ14_05850 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FDZ14_05865 ENOG4105CD3 dihydroorotase FDZ14_05880 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FDZ14_05895 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FDZ14_05910 ENOG4105DSJ YicC domain protein FDZ14_05915 ENOG4105KC4 UPF0296 protein FDZ14_05920 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FDZ14_05930 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FDZ14_05935 ENOG4105C25 Primosomal protein n' FDZ14_05945 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FDZ14_05950 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FDZ14_05955 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FDZ14_05960 ENOG4108ZF3 Phosphatase FDZ14_05965 ENOG4105D9P serine threonine protein kinase FDZ14_05970 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FDZ14_05975 ENOG4105DJV ribulose-phosphate 3-epimerase FDZ14_05980 ENOG4105FJ0 thiamine FDZ14_05990 ENOG4105VB9 50S ribosomal protein l28 FDZ14_05995 ENOG4108ZAA Alkaline-shock protein FDZ14_06000 ENOG4105DP4 dak2 domain fusion protein ylov FDZ14_06015 ENOG4105EJQ L-serine dehydratase FDZ14_06020 ENOG4105CB5 ATP-dependent DNA helicase recG FDZ14_06025 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) FDZ14_06030 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FDZ14_06035 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FDZ14_06040 ENOG4105CHR reductase FDZ14_06055 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FDZ14_06060 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FDZ14_06065 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) FDZ14_06075 ENOG4105K5M 30s ribosomal protein S16 FDZ14_06080 ENOG4105VB6 UPF0109 protein FDZ14_06090 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FDZ14_06100 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FDZ14_06120 ENOG4105CMV Succinyl-CoA synthetase subunit beta FDZ14_06125 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FDZ14_06130 ENOG4105C79 DNA protecting protein DprA FDZ14_06135 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FDZ14_06140 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FDZ14_06145 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FDZ14_06150 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FDZ14_06155 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FDZ14_06160 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) FDZ14_06165 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FDZ14_06170 ENOG4108ZC9 flagellar basal-body rod protein flgc FDZ14_06175 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FDZ14_06180 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FDZ14_06185 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FDZ14_06200 ENOG4106YF4 Flagellar biosynthesis chaperone FDZ14_06215 ENOG410822I Flagellar hook capping protein FDZ14_06220 ENOG4108JQA flagellar FDZ14_06225 ENOG41068WV flagellar FlbD family protein FDZ14_06235 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FDZ14_06240 ENOG4105DD5 Flagellar motor switch protein FDZ14_06245 ENOG4107YTP response regulator receiver protein FDZ14_06255 ENOG4105CN7 Flagellar biosynthetic protein FliP FDZ14_06260 ENOG4105VS8 Flagellar biosynthetic protein fliq FDZ14_06265 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FDZ14_06270 ENOG4105D00 flagellar biosynthetic protein flhB FDZ14_06275 ENOG4105D7B Flagellar biosynthesis protein flha FDZ14_06280 ENOG4105FZW flagellar biosynthesis regulator FlhF FDZ14_06290 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FDZ14_06295 ENOG4105CBS Chea signal transduction histidine kinase FDZ14_06300 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis FDZ14_06305 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) FDZ14_06310 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDZ14_06320 ENOG4105CE9 30S ribosomal protein S2 FDZ14_06325 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FDZ14_06330 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FDZ14_06335 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FDZ14_06340 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FDZ14_06345 ENOG4105KNE Phosphatidate cytidylyltransferase FDZ14_06350 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FDZ14_06355 ENOG4105DZP Membrane-associated zinc metalloprotease FDZ14_06360 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FDZ14_06365 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FDZ14_06370 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FDZ14_06375 ENOG4105CHV Transcription elongation factor NusA FDZ14_06380 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FDZ14_06385 ENOG4105VHM ribosomal protein FDZ14_06390 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FDZ14_06395 ENOG4105W7A Protein of unknown function (DUF503) FDZ14_06410 ENOG4105DTN riboflavin biosynthesis protein ribF FDZ14_06415 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FDZ14_06420 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FDZ14_06430 ENOG4105C1V Peptidase, M16 FDZ14_06440 ENOG4105E35 Dipicolinate synthase subunit A FDZ14_06445 ENOG4108S0H Dipicolinic acid synthetase, b subunit FDZ14_06450 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FDZ14_06460 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FDZ14_06470 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FDZ14_06480 ENOG4105CNU cell division protein FtsK FDZ14_06485 ENOG4105FDP GntR family transcriptional regulator FDZ14_06490 ENOG4105DIH basic membrane FDZ14_06495 ENOG4108JQ9 ABC transporter FDZ14_06500 ENOG4105UIB (ABC) transporter FDZ14_06520 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FDZ14_06525 ENOG4105XZV Protein of unknown function (DUF3243) FDZ14_06540 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FDZ14_06545 ENOG4105CEV competence damage-inducible protein FDZ14_06550 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FDZ14_06560 ENOG4105D48 metallophosphoesterase FDZ14_06565 ENOG4105MCT stage V sporulation protein S FDZ14_06575 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FDZ14_06580 ENOG4105DQU oxidoreductase, subunit beta FDZ14_06585 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FDZ14_06600 ENOG4105CUB amino acid FDZ14_06605 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FDZ14_06610 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FDZ14_06615 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FDZ14_06625 ENOG4106F1P AAA ATPase, central domain protein FDZ14_06630 ENOG4105EN6 Membrane FDZ14_06635 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FDZ14_06640 ENOG4105CXI aluminum resistance protein FDZ14_06645 ENOG4105KV4 Transcriptional regulator FDZ14_06650 ENOG4105C5F glutamine synthetase FDZ14_06660 ENOG4105C0X amino acid FDZ14_06665 ENOG41076HS cation diffusion facilitator family transporter FDZ14_06670 ENOG4105CKK Glycosyl transferase, family 2 FDZ14_06690 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FDZ14_06700 ENOG4108SVB resolvase FDZ14_06705 ENOG4105VPS UPF0291 protein FDZ14_06720 ENOG4105VXM UPF0154 protein FDZ14_06725 ENOG4105BZ1 (ABC) transporter FDZ14_06730 ENOG4105BZ1 (ABC) transporter FDZ14_06740 ENOG4107QIV Cytochrome c biogenesis protein FDZ14_06745 ENOG4108U5N UPF0316 protein FDZ14_06760 ENOG4108JPW Aminotransferase FDZ14_06770 ENOG4105C26 Dehydrogenase FDZ14_06785 ENOG4105BZU Histidine kinase FDZ14_06790 ENOG4105CVP deoxyribo-dipyrimidine photolyase FDZ14_06810 ENOG4105DY8 decarboxylase FDZ14_06840 ENOG4105CIY formyltetrahydrofolate deformylase FDZ14_06845 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FDZ14_06850 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FDZ14_06860 ENOG4105C7B Threonine dehydratase FDZ14_06870 ENOG4108RCR degv family FDZ14_06880 ENOG4108KF3 Electron transport protein SCO1 SenC FDZ14_06885 ENOG41090WU lipolytic protein G-D-S-L family FDZ14_06910 ENOG4105BZU Histidine kinase FDZ14_06925 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FDZ14_06940 ENOG4107S4Y M20 DapE family protein YgeY FDZ14_06945 ENOG4108TSC N-acetyltransferase FDZ14_06950 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FDZ14_06960 ENOG4105F0I Aminotransferase FDZ14_06965 ENOG4108TGC Acyltransferase FDZ14_06975 ENOG4105VSD UPF0346 protein FDZ14_07000 ENOG4105D9P serine threonine protein kinase FDZ14_07005 ENOG4108N23 SpoOM-related protein FDZ14_07010 ENOG410841Q phosphoesterase PA-phosphatase related protein FDZ14_07015 ENOG4106Z5R FDZ14_07020 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FDZ14_07025 ENOG4105CHH sulfate transporter FDZ14_07045 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FDZ14_07065 ENOG4105C5Y PTS System FDZ14_07075 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FDZ14_07100 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FDZ14_07115 ENOG4108JYZ YitT family FDZ14_07130 ENOG4105DVE abc transporter atp-binding protein FDZ14_07150 ENOG4108NHD germination protein FDZ14_07165 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FDZ14_07180 ENOG4105CTQ phosphohexokinase FDZ14_07185 ENOG4107YZX Universal stress protein FDZ14_07190 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FDZ14_07200 ENOG4105C37 (CBS) domain FDZ14_07205 ENOG4105K4I Scp-like extracellular FDZ14_07210 ENOG4105D64 Mechanosensitive ion channel FDZ14_07230 ENOG4108NIW Leucine export protein LeuE FDZ14_07245 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) FDZ14_07250 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FDZ14_07255 ENOG4105C1Q protoporphyrinogen oxidase FDZ14_07305 ENOG4105C85 amino acid FDZ14_07320 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDZ14_07330 ENOG4105K7W phage-related replication protein FDZ14_07335 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FDZ14_07340 ENOG4105KT7 mgtC SapB transporter FDZ14_07345 ENOG4108RYK Nad-dependent epimerase dehydratase FDZ14_07350 ENOG4108Z7F N-acetyltransferase FDZ14_07360 ENOG4107RSM transcriptional regulator FDZ14_07370 ENOG4105J7D transcriptional regulator FDZ14_07375 ENOG4105JHY Membrane FDZ14_07395 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDZ14_07410 ENOG4105E0M Sulfatase FDZ14_07415 ENOG4108RCF TRANSCRIPTIONal FDZ14_07435 ENOG4105CH6 catalase FDZ14_07440 ENOG4105EA8 2-Nitropropane dioxygenase FDZ14_07450 ENOG4105CK2 sodium dicarboxylate symporter FDZ14_07455 ENOG4107TSN permease FDZ14_07460 ENOG4108HGU Histidine kinase FDZ14_07475 ENOG4107YY3 extracellular solute-binding protein family 1 FDZ14_07485 ENOG4105DRS transport system, permease FDZ14_07495 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_07510 ENOG4108IJ8 ABC transporter FDZ14_07515 ENOG4105E90 ABC transporter FDZ14_07525 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FDZ14_07535 ENOG4108RCF TRANSCRIPTIONal FDZ14_07545 ENOG4105DC7 peptidase M24 FDZ14_07550 ENOG41064HX Suppressor of fused protein (SUFU) FDZ14_07560 ENOG4105DRR Transcriptional regulator, GntR family FDZ14_07565 ENOG4108S4H thioesterase Superfamily protein FDZ14_07575 ENOG4105F3H Histidine kinase FDZ14_07585 ENOG4105C0H protease FDZ14_07605 ENOG4107ZYR domain protein FDZ14_07610 ENOG4105CZN Potassium uptake protein FDZ14_07630 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FDZ14_07640 ENOG4108IQI permease FDZ14_07660 ENOG4108ZJ4 polysaccharide deacetylase FDZ14_07665 ENOG4105JVQ RNA Polymerase FDZ14_07670 ENOG4108P49 AntiSigma factor FDZ14_07680 ENOG4106YBV Methyl-accepting chemotaxis FDZ14_07700 ENOG4105CKK Glycosyl transferase, family 2 FDZ14_07705 ENOG4107QQG Dehydrogenase FDZ14_07720 ENOG4106A3M Cytochrome p-450 FDZ14_07735 ENOG4105KVH Transcriptional regulator FDZ14_07740 ENOG4105E39 Enoyl-CoA hydratase FDZ14_07745 ENOG4105EEM helicase FDZ14_07755 ENOG4105WFK nuclease FDZ14_07760 ENOG4105XTG Pfam:DUF156 FDZ14_07765 ENOG4105ME7 Membrane FDZ14_07780 ENOG4105EWM Histidine kinase FDZ14_07790 ENOG4105C19 ABC transporter FDZ14_07830 ENOG4108HKT sucrose-6-phosphate hydrolase FDZ14_07855 ENOG4107SWG transcriptional regulator MERR family FDZ14_07865 ENOG4105CPC Aldo Keto reductase FDZ14_07870 ENOG4105VUF Transcriptional regulator FDZ14_07915 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FDZ14_07920 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FDZ14_07940 ENOG4107QJZ Glycosyl transferase, family 2 FDZ14_07960 ENOG4108ZRV stage ii sporulation protein p FDZ14_07975 ENOG4108XI2 Domain of unknown function (DUF1963) FDZ14_07985 ENOG4105C26 Dehydrogenase FDZ14_07990 ENOG4105C85 amino acid FDZ14_08015 ENOG4105VEQ Cold shock protein FDZ14_08025 ENOG4105QIV RNA polymerase FDZ14_08035 ENOG4107MII Sugar-specific transcriptional regulator TrmB FDZ14_08040 ENOG4105CZM Major Facilitator FDZ14_08045 ENOG4105K4H Nlp p60 protein FDZ14_08060 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FDZ14_08065 ENOG4106I4J membrane FDZ14_08085 ENOG4108KAM Transcriptional regulator FDZ14_08090 ENOG4105C7F AcnD-accessory protein PrpF FDZ14_08120 ENOG4108RIR Molybdenum cofactor biosynthesis protein FDZ14_08130 ENOG4105CVM Molybdenum cofactor synthesis domain protein FDZ14_08215 ENOG4105YWU small acid-soluble spore protein FDZ14_08265 ENOG4108NHD germination protein FDZ14_08270 ENOG4105E1K spore germination protein FDZ14_08295 ENOG4105RXJ FDZ14_08300 ENOG4105KPY Small multidrug resistance protein FDZ14_08305 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold FDZ14_08310 ENOG4105YWU small acid-soluble spore protein FDZ14_08370 ENOG4105C6K Malic enzyme FDZ14_08380 ENOG4107KM7 Heat induced stress protein YflT FDZ14_08385 ENOG4105WDR FDZ14_08390 ENOG4105F27 Major Facilitator FDZ14_08400 ENOG4108W5M transcriptional regulator FDZ14_08405 ENOG4105K7K Transcriptional regulator FDZ14_08425 ENOG4107RB3 L-asparaginase FDZ14_08435 ENOG4107FCW Abortive infection protein FDZ14_08490 ENOG4108NGU Transcriptional regulator FDZ14_08495 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FDZ14_08500 ENOG4105C5Y PTS System FDZ14_08510 ENOG4105DWV Homoserine O-trans-acetylase FDZ14_08515 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FDZ14_08535 ENOG4105ST3 Transcriptional regulator FDZ14_08550 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_08580 ENOG4108VGI doxx family FDZ14_08585 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FDZ14_08595 ENOG4105CHJ isochorismatase hydrolase FDZ14_08640 ENOG4107V2S Transcriptional regulator FDZ14_08645 ENOG4105MDS 4-oxalocrotonate tautomerase FDZ14_08665 ENOG4105DHF Membrane FDZ14_08675 ENOG41086D8 Transcriptional regulator FDZ14_08680 ENOG4105CT4 transporter FDZ14_08685 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FDZ14_08695 ENOG4105CJQ hydrolase, family 31 FDZ14_08745 ENOG4105J4Q Transcriptional regulator FDZ14_08750 ENOG4105D7K pfkb domain protein FDZ14_08760 ENOG4105CXK mandelate racemase muconate lactonizing FDZ14_08765 ENOG4105DJB Major Facilitator Superfamily FDZ14_08815 ENOG4105EGS Mechanosensitive ion channel FDZ14_08820 ENOG4107U9T Pfam:Ribonuclease_BN FDZ14_08865 ENOG4107KM7 Heat induced stress protein YflT FDZ14_08870 ENOG41080XP Cbs domain FDZ14_08900 ENOG4105E2A Dehydrogenase FDZ14_08905 ENOG4105PGS Spore coat protein FDZ14_08925 ENOG4105BZU Histidine kinase FDZ14_08930 ENOG4108NEV two component transcriptional regulator, LytTR family FDZ14_08935 ENOG4105ETE Transcriptional regulator (LacI family FDZ14_08950 ENOG4105CIB oxidoreductase Domain protein FDZ14_08955 ENOG4107QP6 Xylose isomerase domain protein TIM barrel FDZ14_08960 ENOG4105IE8 Alpha-ketoglutarate permease FDZ14_08970 ENOG4105DTD Dehydrogenase FDZ14_09015 ENOG4105CIS alcohol dehydrogenase FDZ14_09020 ENOG4105DND Transcriptional regulator FDZ14_09030 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) FDZ14_09035 ENOG4108Z7G MaoC domain protein dehydratase FDZ14_09050 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FDZ14_09070 ENOG4105CZN Potassium uptake protein FDZ14_09075 ENOG4105D7N magnesium and cobalt transport protein CorA FDZ14_09085 ENOG4105CNI cell division protein FtsW FDZ14_09095 ENOG4105E1K spore germination protein FDZ14_09120 ENOG4105CZ9 Domain of unknown function (DU1801) FDZ14_09125 ENOG4108ZMX Domain of unknown function (DU1801) FDZ14_09155 ENOG4105PGZ NB-ARC domain FDZ14_09160 ENOG4105CPQ Dehydrogenase FDZ14_09165 ENOG4105CT4 transporter FDZ14_09195 ENOG41069DP small acid-soluble spore protein FDZ14_09215 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FDZ14_09250 ENOG4105D9N nucleoside FDZ14_09255 ENOG4108RPX mosc domain containing protein FDZ14_09310 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FDZ14_09320 ENOG4105CE1 Ferrous iron transport protein b FDZ14_09325 ENOG4105CE1 Ferrous iron transport protein b FDZ14_09330 ENOG4105CE1 Ferrous iron transport protein b FDZ14_09340 ENOG4107TVP HD domain protein FDZ14_09345 ENOG4105CMD Transcriptional regulator, GntR family FDZ14_09360 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FDZ14_09365 ENOG4107QNK )-transporter FDZ14_09375 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FDZ14_09430 ENOG4105C5I Dehydrogenase FDZ14_09440 ENOG410667J hydrolase FDZ14_09445 ENOG4105E98 transcriptional regulator DeoR family FDZ14_09455 ENOG4105XPP Protein of unknown function (DUF1275) FDZ14_09475 ENOG4105JXH GntR family transcriptional regulator FDZ14_09525 ENOG4105F1N DNA alkylation repair FDZ14_09540 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FDZ14_09550 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FDZ14_09560 ENOG4106SCS STAS domain FDZ14_09580 ENOG4107QKS N-acylglucosamine 2-epimerase FDZ14_09585 ENOG4108VXD carboxy-peptidase FDZ14_09590 ENOG4105VEQ Cold shock protein FDZ14_09615 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FDZ14_09630 ENOG4105VUF Transcriptional regulator FDZ14_09635 ENOG4105DQ4 alcohol dehydrogenase FDZ14_09645 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FDZ14_09650 ENOG4107QNK )-transporter FDZ14_09655 ENOG4107VG4 Xylose isomerase domain protein TIM barrel FDZ14_09660 ENOG4105D2N Aldolase FDZ14_09670 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FDZ14_09675 ENOG4105DH8 myo-inositol catabolism FDZ14_09695 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FDZ14_09700 ENOG4105F0H myo-inositol catabolism protein FDZ14_09705 ENOG4105ETE Transcriptional regulator (LacI family FDZ14_09730 ENOG4105SKE transcriptional Regulator LysR family FDZ14_09750 ENOG410900G Protein of unknown function (DUF421) FDZ14_09760 ENOG4105VMP Transcriptional regulator FDZ14_09795 ENOG4105CJ1 ABC, transporter FDZ14_09810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDZ14_09815 ENOG4105BZU Histidine kinase FDZ14_09820 ENOG4105KAC Antibiotic biosynthesis monooxygenase FDZ14_09850 ENOG4105D2H Uronic isomerase FDZ14_09860 ENOG4105DMW Dehydrogenase reductase FDZ14_09865 ENOG4105DVM PP-loop domain protein FDZ14_09870 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase FDZ14_09875 ENOG4105C8M UPF0272 protein FDZ14_09880 ENOG4107WBR Protein of unknown function DUF111 FDZ14_09885 ENOG4105CT4 transporter FDZ14_09895 ENOG4105CHH sulfate transporter FDZ14_09935 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_09945 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FDZ14_09955 ENOG4105CSH Transporter FDZ14_09960 ENOG4105VEQ Cold shock protein FDZ14_09965 ENOG4105VEQ Cold shock protein FDZ14_09980 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 FDZ14_09990 ENOG4108W15 Protein of unknown function (DUF1456) FDZ14_10050 ENOG41068WN FDZ14_10055 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FDZ14_10060 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FDZ14_10065 ENOG4105KVH Transcriptional regulator FDZ14_10075 ENOG4108V0P LemA family FDZ14_10090 ENOG4105C26 Dehydrogenase FDZ14_10095 ENOG4108TVJ Nitroreductase FDZ14_10100 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FDZ14_10110 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FDZ14_10115 ENOG4105BZU Histidine kinase FDZ14_10135 ENOG4107RSM transcriptional regulator FDZ14_10145 ENOG41080UX Methyltransferase FDZ14_10150 ENOG4105N14 lysine exporter protein LysE YggA FDZ14_10165 ENOG4105X3H Excalibur domain protein FDZ14_10175 ENOG4105CS2 ec 3.2.1.21 FDZ14_10185 ENOG4108S3Y transcriptional regulator FDZ14_10210 ENOG4105GZI Transcriptional regulator FDZ14_10230 ENOG4105XTG Pfam:DUF156 FDZ14_10235 ENOG4105VFE sira family FDZ14_10240 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FDZ14_10255 ENOG4105VFE sira family FDZ14_10260 ENOG4107TPS domain protein FDZ14_10265 ENOG4105VFE sira family FDZ14_10270 ENOG41087NI Sulfite exporter TauE/SafE FDZ14_10285 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDZ14_10300 ENOG4108HVR ABC transporter, permease FDZ14_10305 ENOG4105C19 ABC transporter FDZ14_10310 ENOG4105EWM Histidine kinase FDZ14_10315 ENOG4105CJZ response regulator FDZ14_10320 ENOG4105CPQ Dehydrogenase FDZ14_10325 ENOG4105C1G acyl-Coa dehydrogenase FDZ14_10330 ENOG4105FBW Monooxygenase FDZ14_10355 ENOG41079KZ Major Facilitator Superfamily FDZ14_10365 ENOG4108IY8 ABC, transporter FDZ14_10370 ENOG4106FTQ Taurine ABC transporter, periplasmic FDZ14_10375 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FDZ14_10380 ENOG4108IYU L-aspartate oxidase FDZ14_10390 ENOG4105F6J Alpha beta hydrolase fold FDZ14_10395 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FDZ14_10425 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FDZ14_10435 ENOG41081I9 integral membrane protein FDZ14_10440 ENOG4105EGI Transcriptional regulator FDZ14_10450 ENOG4107KM7 Heat induced stress protein YflT FDZ14_10455 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth FDZ14_10470 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth FDZ14_10500 ENOG4107ETC gas vesicle protein FDZ14_10510 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) FDZ14_10525 ENOG4108MCI Transcriptional regulator, ARAC family FDZ14_10530 ENOG4108UZ3 Transporter FDZ14_10540 ENOG4107QM2 Aldo Keto reductase FDZ14_10565 ENOG4105MWK D-amino acid dehydrogenase, small subunit FDZ14_10570 ENOG4105D9U N-acetyltransferase FDZ14_10575 ENOG4105BZU Histidine kinase FDZ14_10590 ENOG4105JAB phenazine biosynthesis protein, phzf family FDZ14_10600 ENOG4105BZU Histidine kinase FDZ14_10605 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FDZ14_10610 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FDZ14_10625 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FDZ14_10640 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FDZ14_10705 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FDZ14_10715 ENOG4105BZU Histidine kinase FDZ14_10720 ENOG4106AXJ AraC family transcriptional regulator FDZ14_10725 ENOG4105N14 lysine exporter protein LysE YggA FDZ14_10745 ENOG4105WEF catalase FDZ14_10755 ENOG41067SE Tetr family transcriptional regulator FDZ14_10760 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FDZ14_10770 ENOG4105NAE bifunctional deaminase-reductase domain protein FDZ14_10795 ENOG41062ES Transcriptional regulator FDZ14_10810 ENOG4108ZCF integral membrane protein FDZ14_10815 ENOG4108JCI Transcriptional regulator FDZ14_10820 ENOG4108UMN azlc family FDZ14_10830 ENOG4105C98 muts2 protein FDZ14_10845 ENOG4105E98 transcriptional regulator DeoR family FDZ14_10865 ENOG4105C3F Signal peptidase i FDZ14_10870 ENOG4105NF4 modulator of drug activity FDZ14_10885 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FDZ14_10890 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FDZ14_10895 ENOG4105DT3 PTS system, galactitol-specific IIc component FDZ14_10900 ENOG4105CPQ Dehydrogenase FDZ14_10920 ENOG4105F0V Cell wall hydrolase FDZ14_10925 ENOG4105DHS permease protein FDZ14_10930 ENOG4105CM4 permease protein FDZ14_10935 ENOG4108IPW abc transporter atp-binding protein FDZ14_10945 ENOG4105WEF catalase FDZ14_10975 ENOG4108RYK Nad-dependent epimerase dehydratase FDZ14_10985 ENOG4108QY0 Membrane FDZ14_10990 ENOG4105VEQ Cold shock protein FDZ14_10995 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FDZ14_11000 ENOG410814C multidrug resistance protein FDZ14_11005 ENOG4105Y7M Transcriptional regulator, TetR family FDZ14_11015 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FDZ14_11050 ENOG4105D0M Protease HtpX homolog FDZ14_11055 ENOG4108R9S DSBA oxidoreductase FDZ14_11075 ENOG4108JYZ YitT family FDZ14_11095 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FDZ14_11105 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FDZ14_11115 ENOG41087NI Sulfite exporter TauE/SafE FDZ14_11135 ENOG4107QTZ amino acid FDZ14_11140 ENOG410829K Lysine exporter protein (Lyse ygga) FDZ14_11160 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase FDZ14_11205 ENOG4105BZ9 Cytochrome C oxidase, subunit I FDZ14_11215 ENOG41060D1 Quinol oxidase FDZ14_11235 ENOG41068WN FDZ14_11240 ENOG4108KGH TRANSCRIPTIONal FDZ14_11250 ENOG4105CI2 imidazolone-5-propionate hydrolase FDZ14_11260 ENOG4105VCH membrane FDZ14_11285 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDZ14_11335 ENOG4108MK9 spermidine N(1)-acetyltransferase FDZ14_11340 ENOG4107TXC Transcriptional regulator FDZ14_11345 ENOG41067TZ transcriptional regulator, MarR family FDZ14_11350 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_11360 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FDZ14_11365 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FDZ14_11380 ENOG41068WN FDZ14_11390 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FDZ14_11395 ENOG4105C6K Malic enzyme FDZ14_11415 ENOG4108Z40 Transcriptional regulator FDZ14_11420 ENOG4107QTZ amino acid FDZ14_11440 ENOG4105WAB arsR family transcriptional regulator FDZ14_11445 ENOG4105CT4 transporter FDZ14_11455 ENOG4108IMY Transcriptional regulator FDZ14_11460 ENOG4105HDK L-asparaginase FDZ14_11465 ENOG4108IJ0 Aspartate ammonia-lyase FDZ14_11475 ENOG4107BMA Transglycosylase associated protein FDZ14_11515 ENOG4105BZU Histidine kinase FDZ14_11540 ENOG4105FDR Membrane FDZ14_11545 ENOG4105CMU LysR family (Transcriptional regulator FDZ14_11550 ENOG4105BZN citrate synthase FDZ14_11560 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FDZ14_11565 ENOG4107AYK membrAne FDZ14_11585 ENOG4108JYZ YitT family FDZ14_11590 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FDZ14_11600 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FDZ14_11615 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FDZ14_11620 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FDZ14_11625 ENOG4105RHY Pfam:UPF0157 FDZ14_11640 ENOG4108DBC nitroreductase FDZ14_11650 ENOG4105YVS arsR family transcriptional regulator FDZ14_11695 ENOG4105C3F Signal peptidase i FDZ14_11700 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDZ14_11705 ENOG410635A Membrane FDZ14_11755 ENOG4105CH6 catalase FDZ14_11770 ENOG4105G9B Transcriptional regulator FDZ14_11780 ENOG4105C5R Aminotransferase FDZ14_11785 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FDZ14_11790 ENOG4105CAH Chromate FDZ14_11795 ENOG4105FGV Chromate FDZ14_11805 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FDZ14_11815 ENOG4105EVN Prephenate dehydrogenase FDZ14_11840 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FDZ14_11855 ENOG4105C37 (CBS) domain FDZ14_11870 ENOG4108RMU ferritin dps family protein FDZ14_11880 ENOG4105K7W phage-related replication protein FDZ14_11905 ENOG4105BZ1 (ABC) transporter FDZ14_11930 ENOG4105T38 integral membrane protein FDZ14_11940 ENOG4105BZ4 penicillin-binding protein FDZ14_11945 ENOG4105FBA Phospholipase Carboxylesterase FDZ14_11955 ENOG4107ZTW SNARE associated Golgi FDZ14_11965 ENOG4108DBC nitroreductase FDZ14_11970 ENOG41069ER domain protein FDZ14_11980 ENOG4108I0Q anthranilate phosphoribosyltransferase FDZ14_11985 ENOG4108YZ9 Urea amidohydrolase subunit gamma FDZ14_11995 ENOG4105CQM Urea amidohydrolase subunit alpha FDZ14_12040 ENOG41076QQ Glycosyl transferase, family 2 FDZ14_12045 ENOG4105EWK phytoene FDZ14_12060 ENOG4105D7K pfkb domain protein FDZ14_12065 ENOG4105DJB Major Facilitator Superfamily FDZ14_12085 ENOG41080HJ 6-phospho 3-hexuloisomerase FDZ14_12095 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FDZ14_12105 ENOG4107QTZ amino acid FDZ14_12115 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FDZ14_12120 ENOG4105EHG Permease protein FDZ14_12125 ENOG4108IPW abc transporter atp-binding protein FDZ14_12165 ENOG4105FDT acyl-CoA dehydrogenase FDZ14_12170 ENOG4105RHY Pfam:UPF0157 FDZ14_12190 ENOG4105D74 hydrolase FDZ14_12205 ENOG4105CFC Transporter FDZ14_12210 ENOG4105BZU Histidine kinase FDZ14_12225 ENOG4105C32 Amino acid ABC transporter (Permease) FDZ14_12230 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FDZ14_12235 ENOG4105C0Z ABC transporter FDZ14_12240 ENOG4108IV0 ABC, transporter FDZ14_12275 ENOG4105DHF Membrane FDZ14_12285 ENOG4108X3M OsmC Ohr family protein FDZ14_12300 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FDZ14_12305 ENOG4105C7S Dehydrogenase FDZ14_12325 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FDZ14_12330 ENOG4105BZU Histidine kinase FDZ14_12340 ENOG4108VXD carboxy-peptidase FDZ14_12345 ENOG4105H67 Protein of unknown function (DUF421) FDZ14_12355 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FDZ14_12360 ENOG4105D7N magnesium and cobalt transport protein CorA FDZ14_12370 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FDZ14_12385 ENOG4107I77 yiaA/B two helix domain FDZ14_12420 ENOG41069JR FDZ14_12425 ENOG4105DA5 (ABC) transporter FDZ14_12450 ENOG4105DAA L-lactate FDZ14_12455 ENOG4105CQB FAD linked oxidase domain protein FDZ14_12460 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FDZ14_12465 ENOG4105CQB FAD linked oxidase domain protein FDZ14_12470 ENOG4105C82 Malate synthase FDZ14_12475 ENOG4105ERH Fumarylacetoacetate hydrolase FDZ14_12480 ENOG4107HP6 Transcriptional regulator FDZ14_12490 ENOG4105VTR Integrase FDZ14_12575 ENOG4105D8X mechanosensitive ion channel FDZ14_12590 ENOG4105J7I hydrolase FDZ14_12595 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FDZ14_12600 ENOG4105DWT malate dehydrogenase (quinone) FDZ14_12610 ENOG4107Y9E nuclease FDZ14_12630 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FDZ14_12640 ENOG4107RRN ABC transporter substrate-binding protein FDZ14_12645 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FDZ14_12650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDZ14_12655 ENOG4108RZA ABC transporter FDZ14_12660 ENOG4108JQ7 (ABC) transporter FDZ14_12685 ENOG4105C37 (CBS) domain FDZ14_12690 ENOG4107SUZ Sodium/hydrogen exchanger family FDZ14_12715 ENOG4105CPQ Dehydrogenase FDZ14_12720 ENOG4105CHR reductase FDZ14_12765 ENOG4107V2S Transcriptional regulator FDZ14_12770 ENOG4107QW4 alcohol dehydrogenase FDZ14_12785 ENOG4105CUC YeeE YedE family protein FDZ14_12810 ENOG4105CRW Short chain fatty acid transporter FDZ14_12830 ENOG4107FKK extracellular solute-binding protein family 1 FDZ14_12835 ENOG4105KK4 UPF0060 membrane protein FDZ14_12840 ENOG41069FQ Metallo-beta-lactamase superfamily FDZ14_12845 ENOG4105D0M Protease HtpX homolog FDZ14_12860 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FDZ14_12920 ENOG4107RHR regulatoR FDZ14_12935 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FDZ14_12945 ENOG4105D9N nucleoside FDZ14_12950 ENOG4105IW1 AmiS UreI transporter FDZ14_12965 ENOG4105KAF membrAne FDZ14_12970 ENOG4105KAF membrAne FDZ14_12995 ENOG4105C3M thioredoxin reductase FDZ14_13010 ENOG41080TC multidrug resistance protein FDZ14_13025 ENOG4105DC1 bifunctional purine biosynthesis protein purh FDZ14_13040 ENOG4108URH decarboxylase FDZ14_13045 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain FDZ14_13050 ENOG4107TVP HD domain protein FDZ14_13075 ENOG4108V4B ThiJ pfpI FDZ14_13095 ENOG4105SX7 Transporter FDZ14_13105 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FDZ14_13115 ENOG4105C0X amino acid FDZ14_13120 ENOG4107PBV potassium channel FDZ14_13135 ENOG4105D52 delta-aminolevulinic acid dehydratase FDZ14_13140 ENOG4105G7B Protein of unknown function (DUF2992) FDZ14_13145 ENOG4108Q8B Spore germination protein FDZ14_13150 ENOG4108NHD germination protein FDZ14_13155 ENOG4105K70 DNA-binding protein FDZ14_13170 ENOG4107QTZ amino acid FDZ14_13205 ENOG4107RCI amp-dependent synthetase and ligase FDZ14_13210 ENOG4105H3G oxidoreductase FDZ14_13220 ENOG4107X8Z Acyl-protein synthetase, LuxE FDZ14_13225 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) FDZ14_13255 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FDZ14_13270 ENOG4105VEQ Cold shock protein FDZ14_13345 ENOG4105KAF membrAne FDZ14_13350 ENOG4105C0A alcohol dehydrogenase FDZ14_13360 ENOG4108JUB Transcriptional regulator FDZ14_13365 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FDZ14_13370 ENOG4107QQ0 gntp family FDZ14_13375 ENOG4105BZW Glycerate kinase FDZ14_13395 ENOG4108UB7 FDZ14_13455 ENOG4105DWT malate dehydrogenase (quinone) FDZ14_13480 ENOG4105VZJ PTS System FDZ14_13485 ENOG4105CK1 PTS System FDZ14_13490 ENOG4105F8D glycoside hydrolase family 4 FDZ14_13510 ENOG4105DNP FAD linked oxidase domain protein FDZ14_13525 ENOG4105EC3 peptidase S51, dipeptidase E FDZ14_13550 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FDZ14_13555 ENOG41069ER domain protein FDZ14_13560 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_13565 ENOG4105H67 Protein of unknown function (DUF421) FDZ14_13570 ENOG4105DY9 regulatoR FDZ14_13575 ENOG4105CYC Transferase FDZ14_13615 ENOG4105VEQ Cold shock protein FDZ14_13625 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDZ14_13630 ENOG4105VEQ Cold shock protein FDZ14_13635 ENOG4106KE4 Dehydrogenase FDZ14_13645 ENOG4105CJ1 ABC, transporter FDZ14_13650 ENOG4108TU7 Inherit from COG: (ABC) transporter FDZ14_13665 ENOG4105CGH 5'-nucleotidase FDZ14_13670 ENOG4108N0M stress protein FDZ14_13675 ENOG4106FN3 tellurium resistance protein FDZ14_13680 ENOG4106FN3 tellurium resistance protein FDZ14_13685 ENOG4108TTB tellurium resistance protein FDZ14_13695 ENOG4105E98 transcriptional regulator DeoR family FDZ14_13700 ENOG4105D9R oxidoreductase FDZ14_13705 ENOG41090KN UPF0303 protein FDZ14_13715 ENOG4105CGK Exodeoxyribonuclease III FDZ14_13720 ENOG4105FS7 Transcriptional regulator FDZ14_13730 ENOG4105CW7 secretion protein, HlyD family FDZ14_13735 ENOG4105UQX Mate efflux family protein FDZ14_13810 ENOG4105CUB amino acid FDZ14_13825 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FDZ14_13830 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FDZ14_13835 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FDZ14_13840 ENOG4107T5V SNARE associated Golgi FDZ14_13850 ENOG4105DEN Luciferase family FDZ14_13880 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FDZ14_13885 ENOG4105WH1 Two component transcriptional regulator luxr family FDZ14_13895 ENOG4105CJ1 ABC, transporter FDZ14_13910 ENOG4105C0A alcohol dehydrogenase FDZ14_13915 ENOG4105CY2 Citrate transporter FDZ14_13925 ENOG4107R7Y intracellular protease Pfpi family FDZ14_13935 ENOG4105CQB FAD linked oxidase domain protein FDZ14_13940 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FDZ14_13945 ENOG4105DEN Luciferase family FDZ14_13965 ENOG4107TT2 Auxin Efflux Carrier FDZ14_13970 ENOG4106P55 Transcriptional regulator FDZ14_13975 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FDZ14_13980 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FDZ14_13985 ENOG41069ZX FDZ14_13990 ENOG41069ZX FDZ14_14005 ENOG4105C6K Malic enzyme FDZ14_14010 ENOG4107TT2 Auxin Efflux Carrier FDZ14_14060 ENOG4105DER m42 family FDZ14_14070 ENOG4105E4R Precorrin-3B C17-methyltransferase FDZ14_14075 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FDZ14_14080 ENOG4108JTQ reductase FDZ14_14085 ENOG41081F0 Precorrin-8x methylmutase FDZ14_14090 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) FDZ14_14095 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase FDZ14_14105 ENOG4105CIA precorrin-4 C(11)-methyltransferase FDZ14_14110 ENOG4108P62 biosynthesis protein (CbiG) FDZ14_14115 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FDZ14_14120 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FDZ14_14130 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FDZ14_14135 ENOG4108ZRV stage ii sporulation protein p FDZ14_14145 ENOG4107QTZ amino acid FDZ14_14160 ENOG4105BZU Histidine kinase FDZ14_14165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDZ14_14170 ENOG4105CHH sulfate transporter FDZ14_14175 ENOG4108V2W Carbonate dehydratase FDZ14_14185 ENOG4107SWG transcriptional regulator MERR family FDZ14_14190 ENOG4105DXB Major Facilitator superfamily FDZ14_14200 ENOG4105C6X Major Facilitator FDZ14_14215 ENOG4107U9T Pfam:Ribonuclease_BN FDZ14_14230 ENOG4105VBF alkaline shock protein FDZ14_14235 ENOG4105EWC Purine nucleoside phosphorylase FDZ14_14240 ENOG4105F27 Major Facilitator FDZ14_14255 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FDZ14_14310 ENOG4105XRQ Xanthine dehydrogenase accessory factor FDZ14_14320 ENOG4105C7W Xanthine dehydrogenase FDZ14_14355 ENOG4105FDF Could be involved in DNA repair (By similarity) FDZ14_14365 ENOG4107DZX Small, acid-soluble spore protein P FDZ14_14370 ENOG410746C Acid-soluble spore protein O FDZ14_14375 ENOG4108I0Z Aconitate hydratase FDZ14_14380 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FDZ14_14390 ENOG41075ZD Small, acid-soluble spore protein N FDZ14_14400 ENOG41067CD Small, acid-soluble spore protein Tlp FDZ14_14415 ENOG4105W8X HesB YadR YfhF-family protein FDZ14_14420 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FDZ14_14425 ENOG4105K4P CoA-binding domain protein FDZ14_14430 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDZ14_14440 ENOG4107S9D Alpha beta hydrolase FDZ14_14465 ENOG4108Z7F N-acetyltransferase FDZ14_14475 ENOG4108IQI permease FDZ14_14485 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase FDZ14_14490 ENOG4105CPD ethanolamine ammonia-lyase FDZ14_14495 ENOG4107FQ9 ethanolamine ammonia-lyase FDZ14_14500 ENOG4107R55 ethanolamine transporter FDZ14_14520 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FDZ14_14530 ENOG41067TZ transcriptional regulator, MarR family FDZ14_14545 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FDZ14_14560 ENOG4108MK9 spermidine N(1)-acetyltransferase FDZ14_14565 ENOG4105VT2 5-hydroxyisourate hydrolase FDZ14_14580 ENOG4105F6E Acyl-transferase FDZ14_14590 ENOG4105CM2 brancheD-chain amino acid aminotransferase FDZ14_14610 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FDZ14_14615 ENOG4105E5G Alpha beta hydrolase fold FDZ14_14620 ENOG4105C01 Dihydroxy-acid dehydratase FDZ14_14625 ENOG41082BV acetyltransferase FDZ14_14655 ENOG4105BZU Histidine kinase FDZ14_14660 ENOG4105WH1 Two component transcriptional regulator luxr family FDZ14_14680 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) FDZ14_14690 ENOG4107ZYJ bioY protein FDZ14_14695 ENOG4107F3J Amp-dependent synthetase and ligase FDZ14_14725 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid FDZ14_14735 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase FDZ14_14775 ENOG4105C1J atp-dependent rna helicase FDZ14_14780 ENOG4105VEQ Cold shock protein FDZ14_14790 ENOG4108IPJ Membrane FDZ14_14800 ENOG410645S MarR family Transcriptional regulator FDZ14_14805 ENOG4105DCM major facilitator superfamily FDZ14_14815 ENOG4105DBI uridine monophosphokinase FDZ14_14860 ENOG4105DEN Luciferase family FDZ14_14875 ENOG4105WAB arsR family transcriptional regulator FDZ14_14890 ENOG4108JYZ YitT family FDZ14_14900 ENOG4108JYZ YitT family FDZ14_14930 ENOG4105C28 cystathionine FDZ14_14940 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FDZ14_14945 ENOG4105CV8 reductase FDZ14_14955 ENOG4105F27 Major Facilitator FDZ14_14990 ENOG4105CG3 alpha amylase, catalytic region FDZ14_14995 ENOG4105E7W lamb ycsf family protein FDZ14_15000 ENOG4105C5A transporter FDZ14_15005 ENOG4105CFM UPF0317 protein FDZ14_15010 ENOG4105P4J Allophanate hydrolase, subunit 1 FDZ14_15025 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FDZ14_15030 ENOG4107258 Transcriptional regulator FDZ14_15035 ENOG4105EXQ uroporphyrinogen iii synthase hem4 FDZ14_15045 ENOG4108VCA G U mismatch-specific DNA glycosylase FDZ14_15050 ENOG4105DIN metallophosphoesterase FDZ14_15060 ENOG4108RE9 Phosphodiesterase FDZ14_15070 ENOG4105C8Q Methyl-accepting chemotaxis FDZ14_15075 ENOG4105IQ5 FAD linked oxidase domain protein FDZ14_15095 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FDZ14_15100 ENOG4105TMB Formate nitrite transporter FDZ14_15130 ENOG4105CVK Glutamate decarboxylase FDZ14_15155 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FDZ14_15160 ENOG41073R8 VanW family FDZ14_15165 ENOG41067TZ transcriptional regulator, MarR family FDZ14_15180 ENOG4105P8F nudix hydrolase FDZ14_15195 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FDZ14_15255 ENOG4105D82 Glutamate dehydrogenase FDZ14_15260 ENOG4105EUZ Beta-lactamase domain protein FDZ14_15265 ENOG4105WS7 Cation transport regulator FDZ14_15285 ENOG4107Y9U Membrane FDZ14_15295 ENOG4107YXZ hydrolase, family 25 FDZ14_15300 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FDZ14_15315 ENOG4108JQ1 Dehydrogenase FDZ14_15320 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FDZ14_15330 ENOG4105NX3 Membrane FDZ14_15345 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FDZ14_15355 ENOG4107YUH hydrolase FDZ14_15365 ENOG41082BM Transcriptional regulator, arsr family FDZ14_15375 ENOG4105BZU Histidine kinase FDZ14_15380 ENOG4105FDP GntR family transcriptional regulator FDZ14_15385 ENOG4108KPW sugar kinase FDZ14_15390 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FDZ14_15395 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FDZ14_15400 ENOG4105XN3 extracellular solute-binding protein family 1 FDZ14_15405 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine FDZ14_15415 ENOG4105EYF MMPL domain protein FDZ14_15420 ENOG41062A4 Transcriptional regulator FDZ14_15425 ENOG4105F27 Major Facilitator FDZ14_15430 ENOG4105CUB amino acid FDZ14_15440 ENOG4105C22 threonyL-tRNA synthetase FDZ14_15445 ENOG4105CBG Sulfatase FDZ14_15450 ENOG4105F0V Cell wall hydrolase FDZ14_15455 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FDZ14_15465 ENOG4105JKW Valine--pyruvate aminotransferase FDZ14_15475 ENOG4108594 Permease of the drug metabolite transporter FDZ14_15485 ENOG4105CPF Cell wall formation (By similarity) FDZ14_15490 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FDZ14_15515 ENOG4106XGU FDZ14_15520 ENOG4105C5X domain protein FDZ14_15525 ENOG4108IQI permease FDZ14_15535 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FDZ14_15555 ENOG4108JPW Aminotransferase FDZ14_15560 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FDZ14_15565 ENOG4105CHU acetyl-coa acetyltransferase FDZ14_15570 ENOG4107QNJ CoA-transferase subunit B FDZ14_15575 ENOG4105D6N CoA-transferase, subunit a FDZ14_15590 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FDZ14_15595 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FDZ14_15600 ENOG4105CGU Enoyl-CoA hydratase FDZ14_15605 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FDZ14_15610 ENOG4105C1G acyl-Coa dehydrogenase FDZ14_15615 ENOG4108N5B 2-phosphosulfolactate phosphatase FDZ14_15630 ENOG4105E39 Enoyl-CoA hydratase FDZ14_15635 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FDZ14_15645 ENOG4105CEY Amp-dependent synthetase and ligase FDZ14_15650 ENOG4105CHR reductase FDZ14_15655 ENOG4105C1G acyl-Coa dehydrogenase FDZ14_15665 ENOG4105BZU Histidine kinase FDZ14_15675 ENOG4107VFR oxidoreductase FDZ14_15685 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FDZ14_15690 ENOG4105CK2 sodium dicarboxylate symporter FDZ14_15700 ENOG4105CMU LysR family (Transcriptional regulator FDZ14_15730 ENOG4105CIN aminoacyl-histidine dipeptidase FDZ14_15735 ENOG4105DTD Dehydrogenase FDZ14_15740 ENOG4105CY2 Citrate transporter FDZ14_15750 ENOG4105D4T Citrate transporter FDZ14_15755 ENOG4108V9W transcriptional regulatory protein FDZ14_15760 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FDZ14_15765 ENOG4108IXY short-chain dehydrogenase reductase FDZ14_15775 ENOG4108RCM Nitroreductase FDZ14_15815 ENOG4105BZU Histidine kinase FDZ14_15825 ENOG4107YXZ hydrolase, family 25 FDZ14_15835 ENOG4105C9Q fumarate hydratase class II FDZ14_15850 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FDZ14_15860 ENOG4105E1V na solute symporter FDZ14_15865 ENOG4106CAD Protein of unknown function (DUF3311) FDZ14_15870 ENOG4106SCS STAS domain FDZ14_15885 ENOG4108UW5 maltose o-acetyltransferase FDZ14_15930 ENOG4107U9T Pfam:Ribonuclease_BN FDZ14_15940 ENOG4107TUM Amidinotransferase FDZ14_15945 ENOG4107R13 MMPL domain protein FDZ14_15960 ENOG4105JSC dimethylmenaquinone methyltransferase FDZ14_15975 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FDZ14_15980 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FDZ14_15985 ENOG4105II7 pyrroline-5-carboxylate reductase FDZ14_15990 ENOG4105BZU Histidine kinase FDZ14_16010 ENOG41069ER domain protein FDZ14_16020 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) FDZ14_16035 ENOG4105K56 Transcriptional regulator FDZ14_16040 ENOG4108ZHJ Organic hydroperoxide resistance protein FDZ14_16055 ENOG4105EMN RNA polymerase sigma factor FDZ14_16065 ENOG4105DVE abc transporter atp-binding protein FDZ14_16070 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FDZ14_16075 ENOG4105DUM transcriptional regulator, lysR family FDZ14_16080 ENOG4105D94 Major Facilitator Superfamily FDZ14_16085 ENOG4105KWG Pfam:DUF1696 FDZ14_16100 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FDZ14_16135 ENOG4105C9U ATP-dependent DNA helicase RecQ FDZ14_16180 ENOG41073R8 VanW family FDZ14_16205 ENOG4107S6Z Na H antiporter FDZ14_16225 ENOG4107RZC phospholipase d FDZ14_16235 ENOG4105E2A Dehydrogenase FDZ14_16255 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FDZ14_16265 ENOG4105C9U ATP-dependent DNA helicase RecQ FDZ14_16285 ENOG4105F6S Spore photoproduct lyase FDZ14_16305 ENOG4107S6Z Na H antiporter FDZ14_16315 ENOG4105CJ1 ABC, transporter FDZ14_16320 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ FDZ14_16325 ENOG4108NHD germination protein FDZ14_16330 ENOG4108Q8B Spore germination protein FDZ14_16340 ENOG4105C5H ABC transporter FDZ14_16345 ENOG4108RNG Permease of the drug metabolite transporter FDZ14_16350 ENOG4105FTV AraC Family Transcriptional Regulator FDZ14_16360 ENOG4105DEN Luciferase family FDZ14_16365 ENOG4105EU0 Major facilitator Superfamily FDZ14_16370 ENOG410855V Acylphosphatase FDZ14_16375 ENOG4105DTD Dehydrogenase FDZ14_16380 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FDZ14_16385 ENOG41060GV RNA binding s1 domain protein FDZ14_16390 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FDZ14_16395 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FDZ14_16400 ENOG4105DAP Nicotinate phosphoribosyltransferase FDZ14_16410 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FDZ14_16425 ENOG4108IMY Transcriptional regulator FDZ14_16455 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_16475 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FDZ14_16480 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDZ14_16500 ENOG4105EMU Dehydrogenase FDZ14_16505 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FDZ14_16510 ENOG4108NGU Transcriptional regulator FDZ14_16525 ENOG4105JAB phenazine biosynthesis protein, phzf family FDZ14_16535 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FDZ14_16545 ENOG4105EWU Squalene--hopene cyclase FDZ14_16560 ENOG4105DKW ABC transporter FDZ14_16565 ENOG4108428 Inherit from COG: -acetyltransferase FDZ14_16575 ENOG41075H3 AraC family transcriptional regulator FDZ14_16585 ENOG4108UZ3 Transporter FDZ14_16590 ENOG4107T89 von Willebrand factor, type A FDZ14_16595 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FDZ14_16630 ENOG410606W general stress protein FDZ14_16650 ENOG41062JF Transcriptional regulator FDZ14_16655 ENOG4105I4A GCN5-related N-acetyltransferase FDZ14_16665 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FDZ14_16675 ENOG4108VX5 3-methyladenine DNA glycosylase FDZ14_16680 ENOG4107QP6 Xylose isomerase domain protein TIM barrel FDZ14_16685 ENOG4105CK5 oxidoreductase FDZ14_16705 ENOG4105F0V Cell wall hydrolase FDZ14_16710 ENOG4105C8J )-transporter FDZ14_16725 ENOG4105ETU transcriptional activator (TenA FDZ14_16730 ENOG4105C26 Dehydrogenase FDZ14_16735 ENOG41082YX Transcriptional regulator, arsr family FDZ14_16740 ENOG4108W6C Dehydrogenase FDZ14_16750 ENOG4105EWK phytoene FDZ14_16755 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FDZ14_16765 ENOG4105CFH Aspartokinase FDZ14_16770 ENOG4105DM4 PTS System FDZ14_16775 ENOG4105DE4 1-phosphofructokinase FDZ14_16780 ENOG4105E98 transcriptional regulator DeoR family FDZ14_16790 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FDZ14_16815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDZ14_16830 ENOG4105ECW sulfate abc transporter FDZ14_16835 ENOG4108I5D sulfate abc transporter FDZ14_16840 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FDZ14_16860 ENOG4105EFI regulatoR FDZ14_16865 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FDZ14_16875 ENOG4105CKK Glycosyl transferase, family 2 FDZ14_16880 ENOG4105EDW glycosyl transferase, family 39 FDZ14_16900 ENOG41067MG lrgb family FDZ14_16910 ENOG41061AU MarR family Transcriptional regulator FDZ14_16925 ENOG4107RZC phospholipase d FDZ14_16940 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FDZ14_16960 ENOG4105BZ8 glutamate synthase FDZ14_16965 ENOG4105CBC glutamate synthase FDZ14_16970 ENOG4105C5Q Transcriptional regulator FDZ14_16975 ENOG4108R1P FDZ14_16980 ENOG41069DP small acid-soluble spore protein FDZ14_17005 ENOG4107SWG transcriptional regulator MERR family FDZ14_17020 ENOG4105K7W phage-related replication protein FDZ14_17025 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FDZ14_17030 ENOG4105D7K pfkb domain protein FDZ14_17045 ENOG4105CKV Membrane FDZ14_17050 ENOG410905X membrane-flanked domain protein FDZ14_17060 ENOG4108URH decarboxylase FDZ14_17100 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FDZ14_17120 ENOG4105CDA abc transporter atp-binding protein FDZ14_17155 ENOG4105DEN Luciferase family FDZ14_17160 ENOG410667J hydrolase FDZ14_17170 ENOG4105C6K Malic enzyme FDZ14_17180 ENOG4105DUX Transporter FDZ14_17185 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) FDZ14_17190 ENOG4105US7 Histidine kinase FDZ14_17195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDZ14_17200 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FDZ14_17205 ENOG4108TGC Acyltransferase FDZ14_17220 ENOG4105DFD Na H antiporter FDZ14_17230 ENOG4108NA0 Uncharacterized conserved protein (COG2071) FDZ14_17245 ENOG4105ER2 Ompa motb domain protein FDZ14_17250 ENOG4105E14 MotA TolQ exbB proton channel FDZ14_17265 ENOG41068W2 Cytochrome p-450 FDZ14_17270 ENOG4105C26 Dehydrogenase FDZ14_17275 ENOG4108IUM Glycogen debranching enzyme FDZ14_17280 ENOG4107R6U sodium dicarboxylate symporter FDZ14_17290 ENOG4105BZU Histidine kinase FDZ14_17295 ENOG4105IIU Aminopeptidase FDZ14_17325 ENOG4105CDW Resistance protein FDZ14_17360 ENOG4105CHR reductase FDZ14_17365 ENOG4107QMU Mate efflux family protein FDZ14_17370 ENOG4105KRN Transcriptional regulator, abrb family FDZ14_17390 ENOG4108AEY RNA polymerase sigma factor FDZ14_17395 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FDZ14_17400 ENOG4105II7 pyrroline-5-carboxylate reductase FDZ14_17425 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FDZ14_17430 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FDZ14_17435 ENOG4105CKI cobalamin synthesis protein FDZ14_17445 ENOG4105FR1 rard protein FDZ14_17450 ENOG4108WBT adenosyltransferase FDZ14_17460 ENOG4105CVJ phosphoglycerate mutase FDZ14_17465 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FDZ14_17480 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FDZ14_17490 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FDZ14_17495 ENOG4105SZ6 Thioredoxin FDZ14_17505 ENOG4107YX5 Pfam:DUF548 FDZ14_17510 ENOG4108Y6J UPF0403 protein FDZ14_17515 ENOG4108ZJ4 polysaccharide deacetylase FDZ14_17525 ENOG4105C5H ABC transporter FDZ14_17535 ENOG4108V06 Glutathione peroxidase FDZ14_17555 ENOG4105CVG Homoserine O-transsuccinylase FDZ14_17615 ENOG4105KHC sulfurtransferase FDZ14_17625 ENOG4105X5K response regulator receiver protein FDZ14_17635 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FDZ14_17655 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FDZ14_17660 ENOG4105KVH Transcriptional regulator FDZ14_17665 ENOG4105CZM Major Facilitator FDZ14_17670 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FDZ14_17675 ENOG4105DRR Transcriptional regulator, GntR family FDZ14_17680 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FDZ14_17695 ENOG4108QY0 Membrane FDZ14_17700 ENOG41081VB Hydrolase FDZ14_17705 ENOG4108VUY thioesterase Superfamily protein FDZ14_17715 ENOG4107R5R arsenical pump membrane protein FDZ14_17720 ENOG41082YX Transcriptional regulator, arsr family FDZ14_17765 ENOG41090UD (LipO)protein FDZ14_17775 ENOG4105C59 p-type ATPase FDZ14_17780 ENOG410681U heavy metal transport detoxification protein FDZ14_17785 ENOG4105VPX protein, conserved in bacteria FDZ14_17795 ENOG4105BZU Histidine kinase FDZ14_17800 ENOG4107YZX Universal stress protein FDZ14_17820 ENOG4105CT4 transporter FDZ14_17835 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FDZ14_17840 ENOG4105C02 permease FDZ14_17865 ENOG4105C28 cystathionine FDZ14_17875 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FDZ14_17885 ENOG4107QKR Dehydrogenase FDZ14_17895 ENOG4107RUY (E1 component), alpha subunit FDZ14_17905 ENOG4105C7N Xanthine uracil vitamin C permease FDZ14_17915 ENOG4105E1J oxidoreductase FDZ14_17920 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FDZ14_17925 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FDZ14_17930 ENOG4107YZX Universal stress protein FDZ14_17940 ENOG4105CCU oxidase (Subunit III) FDZ14_17945 ENOG4105BZ9 Cytochrome C oxidase, subunit I FDZ14_17950 ENOG4105E2S oxidase) subunit II FDZ14_17970 ENOG4105D4T Citrate transporter FDZ14_17975 ENOG4108JUB Transcriptional regulator FDZ14_17980 ENOG4107QNK )-transporter FDZ14_17985 ENOG4105CMG Carbohydrate kinase FDZ14_18000 ENOG4105YA8 Transcriptional regulator FDZ14_18010 ENOG4107QZW Altronate oxidoreductase FDZ14_18015 ENOG4105CPQ Dehydrogenase FDZ14_18020 ENOG4105CTX dehydratase FDZ14_18025 ENOG4105UEI Transcriptional Regulator AraC Family FDZ14_18030 ENOG4108I5G Major Facilitator superfamily FDZ14_18040 ENOG4105DMW Dehydrogenase reductase FDZ14_18045 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FDZ14_18050 ENOG4108UHU Aldolase FDZ14_18055 ENOG4105CPQ Dehydrogenase FDZ14_18060 ENOG4105DG4 malate L-lactate dehydrogenase FDZ14_18075 ENOG41080XP Cbs domain FDZ14_18080 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FDZ14_18110 ENOG4105C26 Dehydrogenase FDZ14_18130 ENOG4105CSH Transporter FDZ14_18140 ENOG4108Z66 YbaK ebsC protein FDZ14_18145 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FDZ14_18165 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FDZ14_18195 ENOG4108T9Y Inner membrane protein ydcZ FDZ14_18245 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FDZ14_18260 ENOG4107BMA Transglycosylase associated protein FDZ14_18275 ENOG4107RSM transcriptional regulator FDZ14_18315 ENOG4105YWU small acid-soluble spore protein FDZ14_18345 ENOG4108XET gCN5-related N-acetyltransferase FDZ14_18390 ENOG4105C59 p-type ATPase FDZ14_18410 ENOG4108PJD permease FDZ14_18425 ENOG4108PJD permease FDZ14_18435 ENOG4105KTB nuclear export factor GLE1 FDZ14_18440 ENOG4108T5E Copper resistance protein FDZ14_18490 ENOG41080XP Cbs domain FDZ14_18510 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FDZ14_18515 ENOG4106BXE FDZ14_18565 ENOG4107KM7 Heat induced stress protein YflT FDZ14_18590 ENOG4107KM7 Heat induced stress protein YflT FDZ14_18610 ENOG4108IJ0 Aspartate ammonia-lyase FDZ14_18630 ENOG4108I5G Major Facilitator superfamily FDZ14_18640 ENOG4105CI2 imidazolone-5-propionate hydrolase FDZ14_18650 ENOG4105C84 Histidine ammonia-lyase FDZ14_18655 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) FDZ14_18705 ENOG4105C2C drug resistance transporter, Bcr CflA FDZ14_18730 ENOG4107P26 FDZ14_18735 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FDZ14_18765 ENOG4105E1K spore germination protein FDZ14_18840 ENOG4105VEQ Cold shock protein FDZ14_18900 ENOG4105VEQ Cold shock protein FDZ14_18905 ENOG4105C1J atp-dependent rna helicase FDZ14_18925 ENOG4105ECK Fatty Acid Desaturase FDZ14_18965 ENOG4105MJ9 esterase FDZ14_18980 ENOG4108IMY Transcriptional regulator FDZ14_19000 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FDZ14_19005 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FDZ14_19010 ENOG41085FC arsR family transcriptional regulator FDZ14_19020 ENOG41082YX Transcriptional regulator, arsr family FDZ14_19025 ENOG4107R5R arsenical pump membrane protein FDZ14_19045 ENOG4108M26 parallel beta-helix repeat protein FDZ14_19050 ENOG4108MK9 spermidine N(1)-acetyltransferase FDZ14_19070 ENOG4105KVH Transcriptional regulator FDZ14_19085 ENOG4108I0C methyltransferase FDZ14_19120 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein FDZ14_19125 ENOG4105VRS hydrolase family 18 FDZ14_19130 ENOG4105C6Z Gluconate FDZ14_19135 ENOG4105C01 Dihydroxy-acid dehydratase FDZ14_19140 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FDZ14_19160 ENOG4107HP6 Transcriptional regulator FDZ14_19165 ENOG4105DXI Major Facilitator superfamily FDZ14_19170 ENOG4107U9B transcriptional regulator FDZ14_19175 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FDZ14_19200 ENOG4107R73 Mate efflux family protein FDZ14_19205 ENOG4108JQ7 (ABC) transporter FDZ14_19215 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDZ14_19220 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FDZ14_19225 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FDZ14_19230 ENOG4105DJ2 Major Facilitator Superfamily FDZ14_19245 ENOG41080XP Cbs domain FDZ14_19250 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FDZ14_19255 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FDZ14_19265 ENOG4106GRI small acid-soluble spore protein H FDZ14_19295 ENOG4105C7K acetolactate synthase FDZ14_19305 ENOG4105VEQ Cold shock protein FDZ14_19340 ENOG4105KPY Small multidrug resistance protein FDZ14_19365 ENOG4105XDF Protein of unknown function (DUF1272) FDZ14_19405 ENOG4107TS3 membrane protein, TerC FDZ14_19410 ENOG4108XG4 DNA-binding transcriptional regulator FDZ14_19415 ENOG4105EYF MMPL domain protein FDZ14_19420 ENOG4105GZI Transcriptional regulator FDZ14_19425 ENOG4107RT3 EamA-like transporter family FDZ14_19430 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FDZ14_19435 ENOG4105CHR reductase FDZ14_19440 ENOG4105CY2 Citrate transporter FDZ14_19450 ENOG4105ETE Transcriptional regulator (LacI family FDZ14_19460 ENOG4105C0A alcohol dehydrogenase FDZ14_19495 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF FDZ14_19500 ENOG4105E1K spore germination protein FDZ14_19530 ENOG4107ZTW SNARE associated Golgi FDZ14_19550 ENOG4108PSK reductase FDZ14_19565 ENOG4108XEP Alpha Beta Hydrolase Fold protein FDZ14_19570 ENOG4107V2S Transcriptional regulator FDZ14_19635 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FDZ14_19640 ENOG4108YZG isomerase FDZ14_19660 ENOG41073TP transcriptional regulator FDZ14_19670 ENOG4108IUS Transketolase FDZ14_19675 ENOG4105CV1 Transketolase (EC 2.2.1.1) FDZ14_19685 ENOG4105MKU Transcriptional regulator FDZ14_19695 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FDZ14_19750 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FDZ14_19755 ENOG4108U05 Transcriptional regulator FDZ14_19775 ENOG4105KNA -acetyltransferase FDZ14_19785 ENOG4105VUF Transcriptional regulator FDZ14_19810 ENOG4105DYB Isoaspartyl dipeptidase FDZ14_19820 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FDZ14_19830 ENOG4108903 Formimidoylglutamase FDZ14_19835 ENOG4105CI2 imidazolone-5-propionate hydrolase FDZ14_19845 ENOG4105C84 Histidine ammonia-lyase FDZ14_19860 ENOG4108UIN ybak prolyl-trna synthetase associated region FDZ14_19870 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FDZ14_19875 ENOG4108HKT sucrose-6-phosphate hydrolase FDZ14_19880 ENOG4105F3R pts system mannose fructose sorbose family iid FDZ14_19885 ENOG4105ETZ PTS System FDZ14_19890 ENOG4108IQ3 PTS system FDZ14_19895 ENOG4105YHU PTS system FDZ14_19900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDZ14_19905 ENOG4105EDQ levansucrase EC 2.4.1.10 FDZ14_19910 ENOG4105CNG UPF0061 protein FDZ14_19915 ENOG4108HKT sucrose-6-phosphate hydrolase FDZ14_19925 ENOG4105ETE Transcriptional regulator (LacI family FDZ14_19930 ENOG4105YWU small acid-soluble spore protein FDZ14_19970 ENOG4105CN5 Metallo-Beta-Lactamase FDZ14_20000 ENOG4105C26 Dehydrogenase FDZ14_20015 ENOG4107RGD Major Facilitator superfamily FDZ14_20020 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) FDZ14_20025 ENOG4105EXW epimerase dehydratase FDZ14_20035 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_20040 ENOG4108UQY Iron-storage protein FDZ14_20045 ENOG4108HKT sucrose-6-phosphate hydrolase FDZ14_20050 ENOG4105EDQ levansucrase EC 2.4.1.10 FDZ14_20055 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FDZ14_20070 ENOG4105CUB amino acid FDZ14_20080 ENOG4108MJI response regulator FDZ14_20085 ENOG4105BZU Histidine kinase FDZ14_20105 ENOG4108IJ7 Glycine betaine FDZ14_20110 ENOG4105DVW rieske (2Fe-2S) FDZ14_20115 ENOG4105F76 Sarcosine oxidase FDZ14_20125 ENOG4108VA3 3-hexulose-6-phosphate synthase FDZ14_20130 ENOG4105KVH Transcriptional regulator FDZ14_20135 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FDZ14_20155 ENOG4105C2C drug resistance transporter, Bcr CflA FDZ14_20160 ENOG4105C28 cystathionine FDZ14_20170 ENOG4105E0A ABC, transporter FDZ14_20180 ENOG4105DQ5 transport system permease protein FDZ14_20185 ENOG4105EHG Permease protein FDZ14_20210 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_20215 ENOG4105CW7 secretion protein, HlyD family FDZ14_20220 ENOG41067TZ transcriptional regulator, MarR family FDZ14_20235 ENOG4107ZXU DSBA oxidoreductase FDZ14_20240 ENOG4105G6Z alkaline phosphatase FDZ14_20250 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FDZ14_20255 ENOG4106P19 photosystem i assembly btpa FDZ14_20260 ENOG4105C6Z Gluconate FDZ14_20265 ENOG4105FDP GntR family transcriptional regulator FDZ14_20285 ENOG41069H0 dihydroorotase EC 3.5.2.3 FDZ14_20320 ENOG41087PP glycosyltransferase MGT family FDZ14_20325 ENOG4105K4H Nlp p60 protein FDZ14_20335 ENOG4108TM9 integral membrane protein FDZ14_20340 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FDZ14_20345 ENOG4105IIP Membrane FDZ14_20355 ENOG4105ECK Fatty Acid Desaturase FDZ14_20360 ENOG4108ZGX Histidine kinase FDZ14_20365 ENOG4108S01 response regulator FDZ14_20395 ENOG4105BZU Histidine kinase FDZ14_20400 ENOG4105KNA -acetyltransferase FDZ14_20415 ENOG4108JQ7 (ABC) transporter FDZ14_20420 ENOG4107SN7 NLP P60 protein FDZ14_20425 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FDZ14_20435 ENOG4105C3U ABC transporter FDZ14_20440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDZ14_20445 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FDZ14_20450 ENOG4108ME1 Peptidase M55 D-aminopeptidase FDZ14_20495 ENOG41081VK Ribonuclease FDZ14_20520 ENOG410756H nucleotidyltransferase FDZ14_20525 ENOG410890F Dynamin family FDZ14_20535 ENOG41065KQ synthase FDZ14_20555 ENOG4105C2W permease FDZ14_20560 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FDZ14_20565 ENOG4105CTD carboxy-peptidase FDZ14_20570 ENOG4105DVT helicase FDZ14_20590 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FDZ14_20605 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FDZ14_20615 ENOG4105WH1 Two component transcriptional regulator luxr family FDZ14_20620 ENOG4105ENE Histidine kinase FDZ14_20645 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FDZ14_20650 ENOG4106F55 Protein of unknown function (DUF1273) FDZ14_20660 ENOG4107X2U Inherit from COG: Exonuclease-like protein FDZ14_20665 ENOG4108I5C dEAD DEAH box helicase FDZ14_20675 ENOG4105BZU Histidine kinase FDZ14_20695 ENOG4105CK7 Sodium proline symporter FDZ14_20715 ENOG4105C28 cystathionine FDZ14_20720 ENOG4105C28 cystathionine FDZ14_20730 ENOG4106UIA FDZ14_20775 ENOG4105BZ4 penicillin-binding protein FDZ14_20785 ENOG4105CSM endonuclease III FDZ14_20800 ENOG4105CHM Aminotransferase FDZ14_20810 ENOG4105YAC FDZ14_20820 ENOG4105DVT helicase FDZ14_20825 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FDZ14_20830 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FDZ14_20840 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FDZ14_20845 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FDZ14_20850 ENOG4105CPK Glycosyl transferase (Group 1 FDZ14_20855 ENOG4105FJR Lmbe family FDZ14_20865 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FDZ14_20870 ENOG4108JYZ YitT family FDZ14_20885 ENOG4106UY4 Inherit from COG: Scp-like extracellular FDZ14_20890 ENOG41080XQ Signal transduction protein with cbs domains FDZ14_20925 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FDZ14_20930 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FDZ14_20935 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FDZ14_20940 ENOG4105CNI cell division protein FtsW FDZ14_20955 ENOG4108IAB Phoh family FDZ14_20980 ENOG4105QA2 FDZ14_20985 ENOG4105CI3 gtp-binding protein typa FDZ14_20995 ENOG4105ECY inositol monophosphatase FDZ14_21010 ENOG4105WBI UPF0223 protein FDZ14_21015 ENOG4105CXN decarboxylase FDZ14_21025 ENOG4105C94 Transporter FDZ14_21040 ENOG4105C7S Dehydrogenase FDZ14_21045 ENOG4105CPP Dehydrogenase, E1 component FDZ14_21070 ENOG4108X4Q Hydrolase FDZ14_21075 ENOG4106EHS UPF0356 protein FDZ14_21080 ENOG4105CN5 Metallo-Beta-Lactamase FDZ14_21085 ENOG4107ZYR domain protein FDZ14_21090 ENOG4105BZ1 (ABC) transporter FDZ14_21095 ENOG4105BZ1 (ABC) transporter FDZ14_21105 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FDZ14_21110 ENOG4105D3R alkyl hydroperoxide reductase FDZ14_21115 ENOG4105D8X mechanosensitive ion channel FDZ14_21125 ENOG4105CH2 amidohydrolase FDZ14_21130 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FDZ14_21145 ENOG4107IN1 Protein of unknown function (DUF1797) FDZ14_21160 ENOG4105EPM Diguanylate phosphodiesterase FDZ14_21165 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FDZ14_21180 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FDZ14_21185 ENOG4107R33 ppx gppa phosphatase FDZ14_21190 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein FDZ14_21195 ENOG4105UIN FDZ14_21200 ENOG4107R88 Chemotaxis protein (CheV) FDZ14_21220 ENOG4105CHM Aminotransferase FDZ14_21230 ENOG4105CHR reductase FDZ14_21245 ENOG4105CMU LysR family (Transcriptional regulator FDZ14_21250 ENOG4105VAW lrga family FDZ14_21255 ENOG41067MG lrgb family FDZ14_21260 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FDZ14_21265 ENOG4105KRI phosphocarrier protein (HPr FDZ14_21275 ENOG4105CID antiterminator FDZ14_21285 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FDZ14_21295 ENOG4108R6K riboflavin synthase, subunit alpha FDZ14_21305 ENOG4108K88 Membrane FDZ14_21355 ENOG4105F0V Cell wall hydrolase FDZ14_21385 ENOG4105K4T epimerase FDZ14_21390 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FDZ14_21395 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FDZ14_21400 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase FDZ14_21405 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FDZ14_21425 ENOG4105E1K spore germination protein FDZ14_21440 ENOG4105DFD Na H antiporter FDZ14_21455 ENOG4105BZU Histidine kinase FDZ14_21465 ENOG41090MY MarR family Transcriptional regulator FDZ14_21490 ENOG4105CNN ABC, transporter FDZ14_21495 ENOG4105C2J ABC transporter FDZ14_21505 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FDZ14_21510 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FDZ14_21515 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) FDZ14_21520 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FDZ14_21530 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FDZ14_21535 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FDZ14_21540 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FDZ14_21545 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FDZ14_21550 ENOG4105BZU Histidine kinase FDZ14_21555 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FDZ14_21560 ENOG4107QR9 Iron-sulfur cluster binding protein FDZ14_21565 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FDZ14_21570 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FDZ14_21575 ENOG4105DAP Nicotinate phosphoribosyltransferase FDZ14_21580 ENOG4105JXH GntR family transcriptional regulator FDZ14_21600 ENOG4105CHR reductase FDZ14_21620 ENOG410681C small acid-soluble spore protein FDZ14_21625 ENOG4108WZW RNA polymerase sigma FDZ14_21630 ENOG4107TS3 membrane protein, TerC FDZ14_21635 ENOG4105BZU Histidine kinase FDZ14_21640 ENOG4105DY9 regulatoR FDZ14_21645 ENOG4105G6Z alkaline phosphatase FDZ14_21660 ENOG4108B31 Spore germination protein FDZ14_21665 ENOG4105E0X reductase FDZ14_21685 ENOG4108SDH ABC, transporter FDZ14_21690 ENOG4108IUW ABC transporter FDZ14_21695 ENOG4107Y7X LytTR FDZ14_21705 ENOG4105C7N Xanthine uracil vitamin C permease FDZ14_21715 ENOG4105DP8 Major facilitator superfamily MFS_1 FDZ14_21720 ENOG4105RHY Pfam:UPF0157 FDZ14_21800 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FDZ14_21815 ENOG4105C37 (CBS) domain FDZ14_21820 ENOG4105CJ1 ABC, transporter FDZ14_21860 ENOG4108UQV Membrane FDZ14_21865 ENOG4105CI1 PTS System FDZ14_21870 ENOG4105CE4 GlcNAc 6-P deacetylase FDZ14_21875 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FDZ14_21885 ENOG4108SU4 UPF0309 protein FDZ14_21905 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FDZ14_21910 ENOG4105D7N magnesium and cobalt transport protein CorA FDZ14_21920 ENOG4108KGH TRANSCRIPTIONal FDZ14_21935 ENOG4107QJQ Mate efflux family protein FDZ14_21955 ENOG4105D7K pfkb domain protein FDZ14_21965 ENOG4108QTI )-transporter FDZ14_21970 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FDZ14_21975 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FDZ14_21980 ENOG4108IFG nitrite reductase, (NAD(P)H) FDZ14_22000 ENOG4105C6Z Gluconate FDZ14_22010 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FDZ14_22020 ENOG4105CBC glutamate synthase FDZ14_22035 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FDZ14_22045 ENOG4108KGH TRANSCRIPTIONal FDZ14_22050 ENOG4107YJ4 chain length determinant protein FDZ14_22055 ENOG4105HTX biosynthesis protein FDZ14_22065 ENOG4105DG6 mannose-6-phosphate isomerase FDZ14_22075 ENOG4105D3P Mannan endo-1,4-beta-mannosidase FDZ14_22095 ENOG4105CG5 Glycosyl transferase (Group 1 FDZ14_22105 ENOG4107RA4 Glycosyl transferase (Group 1 FDZ14_22115 ENOG4105C6Y Udp-glucose 6-dehydrogenase FDZ14_22120 ENOG4105D3Q Sugar transferase FDZ14_22125 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FDZ14_22130 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FDZ14_22155 ENOG4107RVV histidinol phosphate phosphatase, hisj family FDZ14_22180 ENOG4105I03 Flagellin FDZ14_22200 ENOG4105PNM synthesis protein FDZ14_22220 ENOG4108JU3 Alkyl hydroperoxide reductase FDZ14_22225 ENOG4105EUJ GTP cyclohydrolase i FDZ14_22230 ENOG4105BZU Histidine kinase FDZ14_22260 ENOG41082BM Transcriptional regulator, arsr family FDZ14_22275 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_22290 ENOG4108JPW Aminotransferase FDZ14_22310 ENOG4105DTQ mandelate racemase muconate lactonizing FDZ14_22330 ENOG4105CV8 reductase FDZ14_22335 ENOG4105JFG SpoIID LytB domain protein FDZ14_22375 ENOG4105E1V na solute symporter FDZ14_22380 ENOG4106CAD Protein of unknown function (DUF3311) FDZ14_22385 ENOG4105C09 Bile acid FDZ14_22390 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FDZ14_22395 ENOG4105CSC Glucose uptake protein FDZ14_22400 ENOG4105KVH Transcriptional regulator FDZ14_22410 ENOG4108M8H domain protein FDZ14_22465 ENOG4105CMR udp-glucose 4-epimerase FDZ14_22475 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FDZ14_22490 ENOG4105CPC Aldo Keto reductase FDZ14_22505 ENOG4108WAV Transcriptional regulator FDZ14_22510 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FDZ14_22515 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FDZ14_22530 ENOG4105E66 phosphoriboisomerase A FDZ14_22545 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FDZ14_22555 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FDZ14_22560 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FDZ14_22565 ENOG4105RD7 BadF BadG BcrA BcrD FDZ14_22575 ENOG4105VCP PTS System FDZ14_22585 ENOG4105F8D glycoside hydrolase family 4 FDZ14_22605 ENOG4106KNT transcriptional regulator FDZ14_22610 ENOG4105F32 YngK protein FDZ14_22690 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FDZ14_22715 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FDZ14_22720 ENOG4105D3R alkyl hydroperoxide reductase FDZ14_22725 ENOG4105EE0 oxidoreductase FDZ14_22730 ENOG4108RYK Nad-dependent epimerase dehydratase FDZ14_22735 ENOG4105VEQ Cold shock protein FDZ14_22740 ENOG4105DZC cytosine deaminase FDZ14_22745 ENOG4105CUB amino acid FDZ14_22760 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FDZ14_22780 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FDZ14_22785 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FDZ14_22805 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FDZ14_22820 ENOG4106F5Q Membrane FDZ14_22825 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase FDZ14_22840 ENOG4108UT2 hemolysin iii FDZ14_22845 ENOG4105C5A transporter FDZ14_22850 ENOG4105E7W lamb ycsf family protein FDZ14_22860 ENOG4105P4J Allophanate hydrolase, subunit 1 FDZ14_22865 ENOG4107414 GntR family transcriptional regulator FDZ14_22870 ENOG4105CG3 alpha amylase, catalytic region FDZ14_22875 ENOG4105C5Y PTS System FDZ14_22885 ENOG4105FF2 Type I DHQase FDZ14_22900 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FDZ14_22905 ENOG4105ETE Transcriptional regulator (LacI family FDZ14_22910 ENOG4105C7N Xanthine uracil vitamin C permease FDZ14_22920 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FDZ14_22935 ENOG4108JPW Aminotransferase FDZ14_22960 ENOG4105BZU Histidine kinase FDZ14_22965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDZ14_22975 ENOG4107QJZ Glycosyl transferase, family 2 FDZ14_23015 ENOG4107XC4 flavin reductase domain protein, FMN-binding FDZ14_23020 ENOG41069ER domain protein FDZ14_23025 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FDZ14_23030 ENOG4105CNN ABC, transporter FDZ14_23035 ENOG4105C2J ABC transporter FDZ14_23040 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FDZ14_23045 ENOG4108RVA ribokinase FDZ14_23050 ENOG4105ETE Transcriptional regulator (LacI family FDZ14_23065 ENOG4105CS1 NAD(P)H quinone oxidoreductase FDZ14_23070 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_23075 ENOG4105CW7 secretion protein, HlyD family FDZ14_23080 ENOG41067TZ transcriptional regulator, MarR family FDZ14_23085 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FDZ14_23095 ENOG4107HP6 Transcriptional regulator FDZ14_23100 ENOG4105MI2 FDZ14_23120 ENOG4105BZ1 (ABC) transporter FDZ14_23125 ENOG4105BZ1 (ABC) transporter FDZ14_23130 ENOG4108JA1 polyketide synthase FDZ14_23135 ENOG4105KVH Transcriptional regulator FDZ14_23140 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDZ14_23150 ENOG4105ECB domain protein FDZ14_23185 ENOG4105KVH Transcriptional regulator FDZ14_23190 ENOG4108VA3 3-hexulose-6-phosphate synthase FDZ14_23195 ENOG41080HJ 6-phospho 3-hexuloisomerase FDZ14_23210 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FDZ14_23220 ENOG4105ETU transcriptional activator (TenA FDZ14_23245 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FDZ14_23270 ENOG4108U1V ABC transporter, permease FDZ14_23275 ENOG4105DQ5 transport system permease protein FDZ14_23280 ENOG4108HUF Transporter FDZ14_23285 ENOG4107T8P acyl-Coa dehydrogenase FDZ14_23290 ENOG4105FBW Monooxygenase FDZ14_23295 ENOG4107T8P acyl-Coa dehydrogenase FDZ14_23305 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FDZ14_23310 ENOG4108UMI ABC transporter, permease FDZ14_23315 ENOG4105D01 (LipO)protein FDZ14_23320 ENOG4107YBY Hydrolase FDZ14_23325 ENOG4105CUB amino acid FDZ14_23335 ENOG4105C8Y Acetylornithine aminotransferase FDZ14_23355 ENOG4108IJ7 Glycine betaine FDZ14_23360 ENOG4107SQ8 Glycine betaine FDZ14_23365 ENOG41089UC methyltransferase, type 11 FDZ14_23370 ENOG4108KK1 membrane protein AbrB duplication FDZ14_23375 ENOG4108KAM Transcriptional regulator FDZ14_23390 ENOG4108MRH transcriptional regulatory protein FDZ14_23400 ENOG4105D4T Citrate transporter FDZ14_23410 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FDZ14_23415 ENOG4108J5H Homocysteine s-methyltransferase FDZ14_23420 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDZ14_23435 ENOG4105E0M Sulfatase FDZ14_23445 ENOG4105VZ8 Transcriptional regulator FDZ14_23450 ENOG4107D63 FDZ14_23470 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FDZ14_23475 ENOG4105CSC Glucose uptake protein FDZ14_23480 ENOG4108MRH transcriptional regulatory protein FDZ14_23485 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FDZ14_23490 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FDZ14_23495 ENOG4105CK2 sodium dicarboxylate symporter FDZ14_23500 ENOG4108ZCF integral membrane protein FDZ14_23510 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FDZ14_23515 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FDZ14_23525 ENOG4108IQI permease FDZ14_23545 ENOG4105EEI dihydropteroate synthase FDZ14_23555 ENOG4107RBB ABC transporter, permease FDZ14_23560 ENOG4105C19 ABC transporter FDZ14_23565 ENOG4107X8C Efflux transporter RND family MFP subunit FDZ14_23580 ENOG4108IXI (ABC) transporter FDZ14_23585 ENOG4105C4B ABC transporter, permease FDZ14_23600 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FDZ14_23605 ENOG4108S4H thioesterase Superfamily protein FDZ14_23615 ENOG4107QTZ amino acid FDZ14_23620 ENOG4105Q95 Cupin 2, conserved barrel domain protein FDZ14_23630 ENOG4105E1V na solute symporter FDZ14_23640 ENOG4105CSV Glutaminase FDZ14_23665 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) FDZ14_23680 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FDZ14_23685 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FDZ14_23690 ENOG4105F27 Major Facilitator FDZ14_23695 ENOG4105KVH Transcriptional regulator FDZ14_23720 ENOG4107FQX Alpha-acetolactate decarboxylase FDZ14_23745 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FDZ14_23760 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FDZ14_23770 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FDZ14_23775 ENOG4108IFG nitrite reductase, (NAD(P)H) FDZ14_23785 ENOG41067MG lrgb family FDZ14_23790 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) FDZ14_23795 ENOG4105DY9 regulatoR FDZ14_23800 ENOG4108HRK Histidine kinase FDZ14_23805 ENOG4105F8D glycoside hydrolase family 4 FDZ14_23810 ENOG4105VCP PTS System FDZ14_23815 ENOG4105CK1 PTS System FDZ14_23820 ENOG4105VZJ PTS System FDZ14_23825 ENOG4105EMD TRANSCRIPTIONal FDZ14_23835 ENOG4108W8B Beta-lactamase domain protein FDZ14_23845 ENOG4105C85 amino acid FDZ14_23850 ENOG4106N3A copper homeostasis protein cutc FDZ14_23855 ENOG4105C1J atp-dependent rna helicase FDZ14_23865 ENOG4107ZXU DSBA oxidoreductase FDZ14_23870 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FDZ14_23890 ENOG4105C6Z Gluconate FDZ14_23895 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FDZ14_23900 ENOG4105CMG Carbohydrate kinase FDZ14_23910 ENOG4106KNT transcriptional regulator FDZ14_23940 ENOG4108ZMI UPF0477 protein FDZ14_23950 ENOG4105H67 Protein of unknown function (DUF421) FDZ14_23960 ENOG4105ENA helicase FDZ14_24015 ENOG4105CJW magnesium transporter FDZ14_24020 ENOG4107S1Q Phosphatase FDZ14_24025 ENOG4105EMS pseudouridine synthase FDZ14_24045 ENOG4105MIX Adenylate cyclase FDZ14_24050 ENOG4105E4C Lytic transglycosylase catalytic FDZ14_24055 ENOG4108Z18 K06886 hemoglobin FDZ14_24060 ENOG4105T58 Dithiol-disulfide isomerase FDZ14_24070 ENOG4105DPN Oligoendopeptidase f FDZ14_24080 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FDZ14_24090 ENOG4108ZCF integral membrane protein FDZ14_24105 ENOG4107RSM transcriptional regulator FDZ14_24110 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FDZ14_24115 ENOG4105D5Q Arginine ornithine antiporter FDZ14_24120 ENOG4105C85 amino acid FDZ14_24130 ENOG4108JQ7 (ABC) transporter FDZ14_24140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDZ14_24145 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FDZ14_24150 ENOG4108J59 Extracellular solute-binding protein, family 5 FDZ14_24155 ENOG4105C31 Tryptophanyl-tRNA synthetase FDZ14_24160 ENOG4108KU1 UPF0736 protein FDZ14_24180 ENOG4108JQ7 (ABC) transporter FDZ14_24185 ENOG4105C3U ABC transporter FDZ14_24195 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FDZ14_24200 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FDZ14_24230 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FDZ14_24235 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase FDZ14_24240 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FDZ14_24255 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FDZ14_24270 ENOG4105DBV ornithine carbamoyltransferase FDZ14_24290 ENOG4105CAS nag kinase FDZ14_24295 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FDZ14_24300 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FDZ14_24305 ENOG4107V6Q Cyclic nucleotide-binding domain FDZ14_24310 ENOG4105VG1 fes assembly suf system protein FDZ14_24315 ENOG4108KP7 hydrolase FDZ14_24325 ENOG4107AYK membrAne FDZ14_24330 ENOG4105EPR degv family FDZ14_24340 ENOG4105QNR S1 RNA binding domain protein FDZ14_24345 ENOG4108VPT UPF0234 protein FDZ14_24350 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FDZ14_24355 ENOG4108JUB Transcriptional regulator FDZ14_24370 ENOG4105C8Y Acetylornithine aminotransferase FDZ14_24375 ENOG4105C26 Dehydrogenase FDZ14_24380 ENOG4105FKQ transcriptional regulator FDZ14_24385 ENOG4108IUK alpha amylase, catalytic FDZ14_24395 ENOG4105FE1 phytoene synthase FDZ14_24410 ENOG4105CAQ asparagine synthetase FDZ14_24465 ENOG4105EYH Exonuclease FDZ14_24475 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FDZ14_24485 ENOG4105CHR reductase FDZ14_24495 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FDZ14_24510 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FDZ14_24620 ENOG4105E39 Enoyl-CoA hydratase FDZ14_24625 ENOG4105CEY Amp-dependent synthetase and ligase FDZ14_24630 ENOG4105DF9 Lipoate-protein, ligase FDZ14_24635 ENOG4108RQ5 Beta-lactamase domain-containing protein FDZ14_24650 ENOG4105C2F Histidine kinase FDZ14_24660 ENOG4107RF6 penicillin-binding protein FDZ14_24670 ENOG4105C1Q protoporphyrinogen oxidase FDZ14_24675 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FDZ14_24680 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FDZ14_24685 ENOG4105BZ4 penicillin-binding protein FDZ14_24690 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FDZ14_24700 ENOG410841Q phosphoesterase PA-phosphatase related protein FDZ14_24725 ENOG4105K59 histidine triad (HIT) protein FDZ14_24730 ENOG4105EXC Acyl-transferase FDZ14_24735 ENOG4107YB6 acetyltransferase, (GNAT) family FDZ14_24740 ENOG4105U3E Transcriptional regulator FDZ14_24745 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FDZ14_24750 ENOG4105NBU tryptophan transport protein FDZ14_24760 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) FDZ14_24785 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FDZ14_24795 ENOG4105EQI Metal Dependent Phosphohydrolase FDZ14_24800 ENOG4105RHA ABC transporter, permease FDZ14_24805 ENOG4108IUX (ABC) transporter FDZ14_24815 ENOG4105K70 DNA-binding protein FDZ14_24820 ENOG4105CGU Enoyl-CoA hydratase FDZ14_24830 ENOG4105D4P Coproporphyrinogen iii oxidase FDZ14_24845 ENOG4105WZB UPF0342 protein FDZ14_24860 ENOG410839P FDZ14_24895 ENOG4105YWU small acid-soluble spore protein FDZ14_24920 ENOG4105DWF phosphomethylpyrimidine kinase FDZ14_24925 ENOG4105D06 uba thif-type nad fad binding protein FDZ14_24940 ENOG41080HI glycine oxidase FDZ14_24945 ENOG4108VEU Thiamine monophosphate synthase FDZ14_24970 ENOG4105DRP amino acid AbC transporter FDZ14_24975 ENOG4105CDA abc transporter atp-binding protein FDZ14_24990 ENOG4108Z40 Transcriptional regulator FDZ14_25000 ENOG4105ED1 spovr family FDZ14_25020 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FDZ14_25025 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FDZ14_25035 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FDZ14_25040 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FDZ14_25045 ENOG4108PXI ErfK YbiS YcfS YnhG FDZ14_25050 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FDZ14_25060 ENOG4108YBP pseudouridine synthase FDZ14_25065 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FDZ14_25075 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FDZ14_25080 ENOG4105DAA L-lactate FDZ14_25085 ENOG4105CB2 alcohol dehydrogenase FDZ14_25110 ENOG4105FR1 rard protein FDZ14_25115 ENOG4108RE7 deoxyribonuclease FDZ14_25130 ENOG4105D4T Citrate transporter FDZ14_25145 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FDZ14_25150 ENOG41090U3 tautomerase FDZ14_25160 ENOG4105FE9 pseudouridine synthase FDZ14_25190 ENOG4108JYZ YitT family FDZ14_25205 ENOG4105ETE Transcriptional regulator (LacI family FDZ14_25230 ENOG4105CK5 oxidoreductase FDZ14_25235 ENOG4105IE8 Alpha-ketoglutarate permease FDZ14_25245 ENOG4105ETE Transcriptional regulator (LacI family FDZ14_25255 ENOG4105YWU small acid-soluble spore protein FDZ14_25270 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FDZ14_25275 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FDZ14_25290 ENOG4108VXD carboxy-peptidase FDZ14_25295 ENOG41069ER domain protein FDZ14_25340 ENOG4105DTQ mandelate racemase muconate lactonizing FDZ14_25355 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FDZ14_25365 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FDZ14_25370 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FDZ14_25380 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FDZ14_25400 ENOG4105CUB amino acid FDZ14_25405 ENOG4105EU9 FDZ14_25410 ENOG4107T5V SNARE associated Golgi FDZ14_25415 ENOG4108REF Sporulation integral membrane protein ytvi FDZ14_25425 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FDZ14_25435 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FDZ14_25450 ENOG41076HS cation diffusion facilitator family transporter FDZ14_25465 ENOG4105CYN Serine protein kinase FDZ14_25470 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FDZ14_25480 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FDZ14_25585 ENOG4105TUA UPF0295 protein FDZ14_25590 ENOG4105G5W regulator Fur family FDZ14_25595 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FDZ14_25615 ENOG4108IUW ABC transporter FDZ14_25620 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FDZ14_25625 ENOG4107NBY Membrane FDZ14_25630 ENOG4105BZ1 (ABC) transporter FDZ14_25635 ENOG4105EVI UPF0374 protein FDZ14_25650 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FDZ14_25655 ENOG4106BXE FDZ14_25660 ENOG4105CEN a g-specific adenine glycosylase FDZ14_25665 ENOG41067AE Membrane-bound metal-dependent hydrolase FDZ14_25675 ENOG4105XHU Acid-soluble spore protein K FDZ14_25685 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr FDZ14_25695 ENOG4105ECP epimerase FDZ14_25715 ENOG4105BZU Histidine kinase FDZ14_25720 ENOG4105C85 amino acid FDZ14_25725 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FDZ14_25755 ENOG4105UPD Calcium Proton FDZ14_25760 ENOG410606W general stress protein FDZ14_25770 ENOG4105PY6 Phenolic acid decarboxylase FDZ14_25780 ENOG4108ISG Major Facilitator FDZ14_25785 ENOG4105PGM cation diffusion facilitator family transporter FDZ14_25790 ENOG4105KTU Transcriptional regulator, arsr family FDZ14_25800 ENOG4105C59 p-type ATPase FDZ14_25805 ENOG4107U9T Pfam:Ribonuclease_BN FDZ14_25815 ENOG4105KJF protein tyrosine phosphatase FDZ14_25825 ENOG4105CPN adenine deaminase FDZ14_25830 ENOG4105K4I Scp-like extracellular FDZ14_25835 ENOG4108Z0Z intracellular protease Pfpi family FDZ14_25840 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FDZ14_25845 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FDZ14_25865 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FDZ14_25870 ENOG4105C5H ABC transporter FDZ14_25885 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FDZ14_25895 ENOG4108K8S endonuclease I FDZ14_25940 ENOG4108IBT Inherit from COG: transposase FDZ14_25950 ENOG4105FDU atp-dependent rna helicase FDZ14_25955 ENOG4105BZU Histidine kinase FDZ14_25970 ENOG4108MRH transcriptional regulatory protein FDZ14_25980 ENOG4105D7N magnesium and cobalt transport protein CorA FDZ14_26000 ENOG4105BZG amino acid carrier protein FDZ14_26010 ENOG4106DF1 FDZ14_26020 ENOG4107R7Y intracellular protease Pfpi family FDZ14_26040 ENOG4108ZHJ Organic hydroperoxide resistance protein FDZ14_26045 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FDZ14_26065 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FDZ14_26075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDZ14_26080 ENOG41062D9 Histidine kinase FDZ14_26095 ENOG4106BRA Membrane FDZ14_26105 ENOG4105DRP amino acid AbC transporter FDZ14_26110 ENOG4105EAD ABC transporter FDZ14_26115 ENOG4105CT1 (ABC) transporter FDZ14_26120 ENOG4105CDA abc transporter atp-binding protein FDZ14_26135 ENOG4105C2C drug resistance transporter, Bcr CflA FDZ14_26140 ENOG4108Z5V transcriptional regulator, merr family FDZ14_26150 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FDZ14_26155 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FDZ14_26160 ENOG4105BZU Histidine kinase FDZ14_26165 ENOG4107RMD Basic membrane lipoprotein FDZ14_26180 ENOG4107AYK membrAne FDZ14_26200 ENOG4105CBD Diacylglycerol kinase FDZ14_26205 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FDZ14_26210 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FDZ14_26215 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FDZ14_26230 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FDZ14_26235 ENOG4105C4R Atp-dependent dna helicase FDZ14_26245 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FDZ14_26250 ENOG4105KGF protein, YerC YecD FDZ14_26265 ENOG4105C12 Phosphoribosylglycinamide synthetase FDZ14_26270 ENOG4105DC1 bifunctional purine biosynthesis protein purh FDZ14_26275 ENOG4108V3E phosphoribosylglycinamide formyltransferase FDZ14_26280 ENOG4105CXB phosphoribosylaminoimidazole synthetase FDZ14_26290 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FDZ14_26295 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FDZ14_26300 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FDZ14_26305 ENOG4105C8V SAICAR synthetase FDZ14_26310 ENOG4105C83 adenylosuccinate lyase FDZ14_26315 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FDZ14_26320 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FDZ14_26375 ENOG4105C7N Xanthine uracil vitamin C permease FDZ14_26380 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FDZ14_26395 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FDZ14_26400 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FDZ14_26405 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FDZ14_26410 ENOG4108TYN CAAX amino terminal protease family protein FDZ14_26420 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FDZ14_26425 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FDZ14_26430 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FDZ14_26435 ENOG4105C5H ABC transporter FDZ14_26440 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FDZ14_26445 ENOG410801F ribosomal-protein-alanine acetyltransferase FDZ14_26450 ENOG41072GX Peptidase M22 Glycoprotease FDZ14_26455 ENOG4105K8N protein family UPF0079, ATPase FDZ14_26555 ENOG41064BQ Phosphatase FDZ14_26570 ENOG4105WN5 stage II sporulation protein FDZ14_26575 ENOG4107SGM protein serine threonine phosphatase FDZ14_26580 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FDZ14_26585 ENOG4105FUA antagonist FDZ14_26590 ENOG4107MMM Anti-sigma-factor antagonist FDZ14_26595 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FDZ14_26605 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FDZ14_26610 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FDZ14_26615 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FDZ14_26630 ENOG4105C1J atp-dependent rna helicase FDZ14_26635 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FDZ14_26640 ENOG4105CPF Cell wall formation (By similarity) FDZ14_26645 ENOG4105I7V membrAne FDZ14_26650 ENOG41081YB ApbE family FDZ14_26660 ENOG4105US7 Histidine kinase FDZ14_26665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDZ14_26675 ENOG4107RUE extracellular solute-binding protein family 1 FDZ14_26680 ENOG4105D38 putrescine abc transporter FDZ14_26700 ENOG4107T7U Sulfatase FDZ14_26705 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FDZ14_26710 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FDZ14_26720 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FDZ14_26725 ENOG4105ETD TRANSCRIPTIONal FDZ14_26730 ENOG4105CTS PTS system mannitol-specific FDZ14_26735 ENOG41068JE domain protein FDZ14_26740 ENOG4105CDY transcriptional regulatory protein FDZ14_26750 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FDZ14_26755 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FDZ14_26765 ENOG4105C8B TIGR00159 family FDZ14_26775 ENOG4105EMN RNA polymerase sigma factor FDZ14_26855 ENOG4108NMV polysaccharide deacetylase FDZ14_26870 ENOG4108KSA LysR family transcriptional regulator FDZ14_26875 ENOG4105D1F ATP-binding protein FDZ14_26895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FDZ14_26900 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FDZ14_26905 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FDZ14_26910 ENOG4108JJB ABC transporter FDZ14_26915 ENOG4108JJB ABC transporter FDZ14_26920 ENOG4108ZT0 50S ribosomal protein l17 FDZ14_26925 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FDZ14_26935 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FDZ14_26940 ENOG41067V7 50S ribosomal protein L36 FDZ14_26945 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FDZ14_26950 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FDZ14_26955 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FDZ14_26960 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FDZ14_26965 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FDZ14_26970 ENOG4105VPB 50S ribosomal protein L30 FDZ14_26975 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FDZ14_26980 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FDZ14_26985 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FDZ14_26990 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FDZ14_26995 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FDZ14_27010 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FDZ14_27015 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FDZ14_27020 ENOG41082SA 50s ribosomal protein l29 FDZ14_27025 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FDZ14_27030 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FDZ14_27035 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FDZ14_27040 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FDZ14_27045 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FDZ14_27050 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FDZ14_27055 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FDZ14_27060 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FDZ14_27070 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FDZ14_27080 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FDZ14_27085 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FDZ14_27090 ENOG4105XPM ribosomal protein FDZ14_27095 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FDZ14_27100 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FDZ14_27105 ENOG4107Y49 methyltransferase FDZ14_27115 ENOG4108VZM 50s ribosomal protein L10 FDZ14_27120 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FDZ14_27130 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FDZ14_27140 ENOG41087NY 50S ribosomal protein L33 FDZ14_27145 ENOG4105QIV RNA polymerase FDZ14_27150 ENOG4105M0M Tetracycline resistance protein FDZ14_27155 ENOG4105C2N RNA methyltransferase TrmH family group 3 FDZ14_27165 ENOG4105C8N cysteinyl-tRNA synthetase FDZ14_27170 ENOG4105D7W serine acetyltransferase FDZ14_27175 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FDZ14_27180 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FDZ14_27185 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FDZ14_27190 ENOG4105CTP PilT protein domain protein FDZ14_27195 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FDZ14_27200 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FDZ14_27210 ENOG41066A3 ATP guanido phosphotransferase FDZ14_27215 ENOG4108Z0C Uvrb UvrC protein FDZ14_27240 ENOG4105CRK lysyL-tRNA synthetase FDZ14_27245 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FDZ14_27250 ENOG4105KRF dihydroneopterin aldolase FDZ14_27255 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FDZ14_27260 ENOG4105DDQ anthranilate synthase FDZ14_27265 ENOG4105CRQ synthase (Component I) FDZ14_27270 ENOG4105C6T cysteine synthase FDZ14_27275 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FDZ14_27280 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FDZ14_27285 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FDZ14_27305 ENOG4105G3A stage ii sporulation protein e FDZ14_27320 ENOG41060GV RNA binding s1 domain protein FDZ14_27335 ENOG4105VYY sporulation protein yabp FDZ14_27340 ENOG41082I2 s4 domain protein FDZ14_27345 ENOG4108IY2 MazG family FDZ14_27355 ENOG4108M14 stage v sporulation protein t FDZ14_27365 ENOG4108JA2 transcriptioN-repair coupling factor FDZ14_27375 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FDZ14_27380 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FDZ14_27390 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FDZ14_27395 ENOG4105K4W Could be involved in septation (By similarity) FDZ14_27400 ENOG4105KME endoribonuclease L-psp FDZ14_27405 ENOG4105DFT pur operon repressor FDZ14_27420 ENOG4105W42 Veg protein FDZ14_27425 ENOG4105XFA sporulation peptidase YabG FDZ14_27430 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FDZ14_27435 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FDZ14_27440 ENOG4105F8V Hydrolase, tatD family FDZ14_27445 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FDZ14_27450 ENOG4105KRN Transcriptional regulator, abrb family FDZ14_27455 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FDZ14_27460 ENOG4105VC4 domain protein FDZ14_27465 ENOG41060K3 Methyltransferase FDZ14_27470 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) FDZ14_27475 ENOG4105MA4 psp1 domain protein FDZ14_27480 ENOG4105FA2 dna polymerase iii FDZ14_27485 ENOG4105X0R protein from nitrogen regulatory protein P-II FDZ14_27490 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FDZ14_27495 ENOG4105CXN decarboxylase FDZ14_27590 ENOG41067KS pro-sigma K processing FDZ14_27600 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FDZ14_27605 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FDZ14_27610 ENOG4105C6E dna polymerase iii FDZ14_27620 ENOG4108Z6B deaminase FDZ14_27625 ENOG4105GTG Isochorismatase FDZ14_27630 ENOG4105VRS hydrolase family 18 FDZ14_27640 ENOG4105ZMH deoxynucleoside kinase FDZ14_27655 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FDZ14_27660 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FDZ14_27670 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FDZ14_27705 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDZ14_27710 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDZ14_27720 ENOG410848D S4 domain protein YaaA FDZ14_27725 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FDZ14_27740 ENOG4105C19 ABC transporter FDZ14_27745 ENOG4107RBB ABC transporter, permease FDZ14_27755 ENOG4105K4I Scp-like extracellular FDZ14_27770 ENOG4105PGM cation diffusion facilitator family transporter FDZ14_27780 ENOG4108TGC Acyltransferase FDZ14_27790 ENOG4108RAV Conserved protein FDZ14_27810 ENOG4105YB8 TM2 domain containing protein FDZ14_27815 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FDZ14_27830 ENOG4105SFS phosphoesterase RecJ domain protein FDZ14_27835 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FDZ14_27875 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin FDZ14_27880 ENOG4105I03 Flagellin FDZ14_27985 ENOG4105F0V Cell wall hydrolase FDZ14_28020 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FDZ14_28035 ENOG4106NNP ICEA Protein FDZ14_28135 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FDZ14_28150 ENOG4105J7I hydrolase FDZ14_28345 ENOG4105DPN Oligoendopeptidase f FDZ14_28365 ENOG4105C3M thioredoxin reductase FDZ14_28375 ENOG4105P0I Adenylate cyclase FDZ14_28405 ENOG4105CEP NADH dehydrogenase FDZ14_28415 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FDZ14_28420 ENOG4105VXM UPF0154 protein FDZ14_28430 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FDZ14_28530 ENOG4105DJ4 phosphatidylserine decarboxylase FDZ14_28555 ENOG4105GIG FDZ14_28560 ENOG4108ZCF integral membrane protein FDZ14_28585 ENOG41068JE domain protein FDZ14_28590 ENOG4108VCI transcription factor, rsfa family FDZ14_28605 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FDZ14_28640 ENOG41067QW Transcriptional regulator FDZ14_28660 ENOG4106I4J membrane FDZ14_28675 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FDZ14_28705 ENOG4105VEQ Cold shock protein FDZ14_28710 ENOG41068JE domain protein FDZ14_28730 ENOG4105D1H recombination factor protein RarA FDZ14_28780 ENOG4105CPF Cell wall formation (By similarity) FDZ14_28800 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FDZ14_28815 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FDZ14_28820 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FDZ14_28835 ENOG4105C37 (CBS) domain FDZ14_28845 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDZ14_28860 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FDZ14_28865 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FDZ14_28870 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FDZ14_28905 ENOG4105E4C Lytic transglycosylase catalytic FDZ14_28910 ENOG4105I03 Flagellin FDZ14_28925 ENOG4105BZ4 penicillin-binding protein FDZ14_28965 ENOG4108IAB Phoh family FDZ14_28975 ENOG4105CZX twitching motility protein FDZ14_29010 ENOG4105C5F glutamine synthetase FDZ14_29100 ENOG4105C0H protease FDZ14_29145 ENOG4105CTJ Metal Dependent Phosphohydrolase FDZ14_29150 ENOG4105ESV Glycosyl transferase, family 4 FDZ14_29180 ENOG4108IJ1 Dehydrogenase FDZ14_29185 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FDZ14_29310 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FDZ14_29315 ENOG41083I7 UPF0145 protein FDZ14_29385 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FDZ14_29390 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FDZ14_29430 ENOG4108S4H thioesterase Superfamily protein FDZ14_29440 ENOG4108V0P LemA family FDZ14_29575 ENOG4108XI2 Domain of unknown function (DUF1963) FDZ14_29665 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FDZ14_29810 ENOG4105CJ1 ABC, transporter FDZ14_29945 ENOG4105CNI cell division protein FtsW FDZ14_30000 ENOG4105C37 (CBS) domain FDZ14_30020 ENOG4105EYF MMPL domain protein FDZ14_30030 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FDZ14_30065 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FDZ14_30165 ENOG4105JVQ RNA Polymerase FDZ14_30245 ENOG4105DVF Cytosine-specific methyltransferase FDZ14_30325 ENOG4105F0V Cell wall hydrolase FDZ14_30340 ENOG4105E66 phosphoriboisomerase A FDZ14_30450 ENOG4107RWR Sodium hydrogen exchanger FDZ14_30650 ENOG4105NBU tryptophan transport protein FDZ14_30830 ENOG4107TT2 Auxin Efflux Carrier FDZ14_30840 ENOG4108U5N UPF0316 protein FDZ14_30880 ENOG4108UT2 hemolysin iii FDZ14_30905 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FDZ14_30910 ENOG4105DD5 Flagellar motor switch protein FDZ14_30915 ENOG4107YTP response regulator receiver protein FDZ14_30920 ENOG4105BZU Histidine kinase FDZ14_30960 ENOG4105VMP Transcriptional regulator FDZ14_30970 ENOG4105YVF chew protein FDZ14_30975 ENOG4105CBS Chea signal transduction histidine kinase FDZ14_31020 ENOG4108ZMQ domain protein FDZ14_31070 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FDZ14_31090 ENOG4105X3H Excalibur domain protein FDZ14_31095 ENOG4105DZ1 carboxypeptidase FDZ14_31100 ENOG4105DZP Membrane-associated zinc metalloprotease FDZ14_31110 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FDZ14_31120 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FDZ14_31130 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FDZ14_31135 ENOG4105CN5 Metallo-Beta-Lactamase FDZ14_31140 ENOG4107TVC Glycosyl transferase, family 2 FDZ14_31180 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FDZ14_31190 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FDZ14_31195 ENOG4105BZU Histidine kinase FDZ14_31205 ENOG4105CAK Cell division ATP-binding protein ftsE FDZ14_31215 ENOG4105CNI cell division protein FtsW FDZ14_31225 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FDZ14_31240 ENOG4105C9U ATP-dependent DNA helicase RecQ FDZ14_31245 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FDZ14_31260 ENOG4105C0B DNA polymerase III (alpha subunit) FDZ14_31275 ENOG4108JQA flagellar FDZ14_31285 ENOG4105FZW flagellar biosynthesis regulator FlhF FDZ14_31290 ENOG4105D7B Flagellar biosynthesis protein flha FDZ14_31295 ENOG4105D00 flagellar biosynthetic protein flhB FDZ14_31305 ENOG4105VS8 Flagellar biosynthetic protein fliq FDZ14_31310 ENOG4105CN7 Flagellar biosynthetic protein FliP FDZ14_31320 ENOG4105DD5 Flagellar motor switch protein FDZ14_31325 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FDZ14_31330 ENOG4107YTP response regulator receiver protein FDZ14_31345 ENOG4105BZE flagellar hook protein, FlgE FDZ14_31375 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FDZ14_31390 ENOG4108ZC9 flagellar basal-body rod protein flgc FDZ14_31505 ENOG4105QIV RNA polymerase FDZ14_31510 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDZ14_31525 ENOG4105EKQ RNA-directed DNA polymerase FDZ14_31535 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FDZ14_31620 ENOG4105CDU Replicative dna helicase FDZ14_31625 ENOG4105C0D helicase FDZ14_31660 ENOG4105DZ1 carboxypeptidase FDZ14_31665 ENOG4107ZQN disulfide bond FDZ14_31675 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FDZ14_31690 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FDZ14_31695 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FDZ14_31710 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FDZ14_31725 ENOG4105F8D glycoside hydrolase family 4 FDZ14_31730 ENOG4105VCP PTS System FDZ14_31735 ENOG4105CK1 PTS System FDZ14_31740 ENOG4105VZJ PTS System FDZ14_31775 ENOG4108UUM single-stranded DNA-binding protein FDZ14_31785 ENOG4105HA9 of methanol dehydrogenase type FDZ14_31790 ENOG4108V0P LemA family FDZ14_31795 ENOG4108W5N phosphatidylglycerophosphatase a FDZ14_31800 ENOG41068JE domain protein FDZ14_31810 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FDZ14_31815 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FDZ14_31825 ENOG4105CYN Serine protein kinase FDZ14_31850 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FDZ14_31890 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDZ14_31895 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDZ14_31920 ENOG4107WZZ SMC domain protein FDZ14_31925 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FDZ14_31930 ENOG4105K70 DNA-binding protein FDZ14_31945 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FDZ14_31995 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FDZ14_32015 ENOG4105ER2 Ompa motb domain protein FDZ14_32020 ENOG4105E14 MotA TolQ exbB proton channel FDZ14_32050 ENOG4105DFU Cell wall formation (By similarity) FDZ14_32060 ENOG4105JFG SpoIID LytB domain protein FDZ14_32065 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FDZ14_32075 ENOG4105C3F Signal peptidase i FDZ14_32170 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FDZ14_32195 ENOG4105I03 Flagellin FDZ14_32235 ENOG4106RPI FDZ14_32240 ENOG4108XI2 Domain of unknown function (DUF1963) FDZ14_32245 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FDZ14_32260 ENOG4105K63 Thioredoxin FDZ14_32275 ENOG4108JYZ YitT family FDZ14_32285 ENOG4107BJW polysaccharide deacetylase FDZ14_32290 ENOG4105PTM secreted protein FDZ14_32295 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FDZ14_32300 ENOG4108Z20 Acyl-transferase FDZ14_32315 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_32330 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FDZ14_32340 ENOG4105KT7 mgtC SapB transporter FDZ14_32350 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FDZ14_32425 ENOG4105C8Q Methyl-accepting chemotaxis FDZ14_32460 ENOG4105VEQ Cold shock protein FDZ14_32480 ENOG4108S4H thioesterase Superfamily protein FDZ14_32485 ENOG4105E4C Lytic transglycosylase catalytic FDZ14_32535 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FDZ14_32580 ENOG4108K5P (LipO)protein FDZ14_32605 ENOG4108UK2 deaminase FDZ14_32625 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FDZ14_32635 ENOG4105K4H Nlp p60 protein FDZ14_32665 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FDZ14_32695 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FDZ14_32715 ENOG4105C8Y Acetylornithine aminotransferase FDZ14_32720 ENOG4105D4A Cell wall formation (By similarity) FDZ14_32740 ENOG4108KGH TRANSCRIPTIONal FDZ14_32750 ENOG4106F1P AAA ATPase, central domain protein FDZ14_32760 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FDZ14_32765 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FDZ14_32770 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FDZ14_32775 ENOG4105E0M Sulfatase FDZ14_32790 ENOG4105BZU Histidine kinase FDZ14_32795 ENOG4105HHA aminodeoxychorismate lyase FDZ14_32815 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FDZ14_32830 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FDZ14_32870 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FDZ14_32890 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FDZ14_32900 ENOG4105C8B TIGR00159 family FDZ14_32940 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FDZ14_32950 ENOG4108WZW RNA polymerase sigma FDZ14_32955 ENOG4107T5V SNARE associated Golgi FDZ14_32980 ENOG4105BZU Histidine kinase FDZ14_33010 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FDZ14_33015 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FDZ14_33020 ENOG4105DAP Nicotinate phosphoribosyltransferase FDZ14_33030 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FDZ14_33065 ENOG4108PB2 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FDZ14_33165 ENOG4107104 thymidine kinase FDZ14_33195 ENOG4105EKQ RNA-directed DNA polymerase FDZ14_33240 ENOG4107ZYR domain protein FDZ14_33245 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FDZ14_33260 ENOG4105DKQ ROK family FDZ14_33310 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_33315 ENOG4105CW7 secretion protein, HlyD family FDZ14_33320 ENOG41067TZ transcriptional regulator, MarR family FDZ14_33335 ENOG410756H nucleotidyltransferase FDZ14_33390 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FDZ14_33420 ENOG4108WBT adenosyltransferase FDZ14_33435 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FDZ14_33445 ENOG4108RMU ferritin dps family protein FDZ14_33460 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FDZ14_33465 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FDZ14_33510 ENOG4105D7W serine acetyltransferase FDZ14_33525 ENOG4105C1B dTDP-glucose 4-6-dehydratase FDZ14_33530 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FDZ14_33550 ENOG4107TVP HD domain protein FDZ14_33555 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain FDZ14_33560 ENOG4108URH decarboxylase FDZ14_33620 ENOG4105CHJ isochorismatase hydrolase FDZ14_33645 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FDZ14_33655 ENOG4105G6Z alkaline phosphatase FDZ14_33690 ENOG4105EWC Purine nucleoside phosphorylase FDZ14_33710 ENOG41087PP glycosyltransferase MGT family FDZ14_33740 ENOG410847I Transcriptional regulator, BadM Rrf2 family FDZ14_33750 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FDZ14_33835 ENOG4108Q5Y Membrane FDZ14_33845 ENOG4107V2S Transcriptional regulator FDZ14_33850 ENOG4108T9Y Inner membrane protein ydcZ FDZ14_33860 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FDZ14_33900 ENOG4107TS3 membrane protein, TerC FDZ14_33905 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FDZ14_33920 ENOG410841Q phosphoesterase PA-phosphatase related protein FDZ14_33950 ENOG4105E1K spore germination protein FDZ14_33965 ENOG4108NA0 Uncharacterized conserved protein (COG2071) FDZ14_33970 ENOG4105CBC glutamate synthase FDZ14_33980 ENOG4105KRN Transcriptional regulator, abrb family FDZ14_33985 ENOG4105VUF Transcriptional regulator FDZ14_33990 ENOG4105EMU Dehydrogenase FDZ14_34010 ENOG4105MCT stage V sporulation protein S FDZ14_34015 ENOG4105K70 DNA-binding protein FDZ14_34040 ENOG4105C1J atp-dependent rna helicase FDZ14_34050 ENOG4105VEQ Cold shock protein FDZ14_34060 ENOG4105ECK Fatty Acid Desaturase FDZ14_34110 ENOG4105QIV RNA polymerase FDZ14_34160 ENOG4105HHM rdd domain containing protein FDZ14_34175 ENOG4108QG2 Membrane FDZ14_34195 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FDZ14_34295 ENOG4105D4T Citrate transporter FDZ14_34305 ENOG4105JSC dimethylmenaquinone methyltransferase FDZ14_34315 ENOG41069H0 dihydroorotase EC 3.5.2.3 FDZ14_34350 ENOG4105DJB Major Facilitator Superfamily FDZ14_34355 ENOG4105YVS arsR family transcriptional regulator FDZ14_34360 ENOG4107XZQ multidrug resistance protein FDZ14_34365 ENOG4108A65 Transcriptional regulator FDZ14_34380 ENOG4105MSB protein, conserved in bacteria FDZ14_34385 ENOG4105EA8 2-Nitropropane dioxygenase FDZ14_34395 ENOG4105ERH Fumarylacetoacetate hydrolase FDZ14_34400 ENOG4107GFK fumarate FDZ14_34405 ENOG4106DSS Tartrate dehydratase subunit alpha FDZ14_34410 ENOG4105D4T Citrate transporter FDZ14_34470 ENOG4105D7N magnesium and cobalt transport protein CorA FDZ14_34480 ENOG4105CNI cell division protein FtsW FDZ14_34490 ENOG410841Q phosphoesterase PA-phosphatase related protein FDZ14_34495 ENOG4107TS3 membrane protein, TerC FDZ14_34515 ENOG4105K70 DNA-binding protein FDZ14_34535 ENOG4105VMP Transcriptional regulator FDZ14_34545 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FDZ14_34555 ENOG4105C5Q Transcriptional regulator FDZ14_34610 ENOG4105K4H Nlp p60 protein FDZ14_34625 ENOG4105DBI uridine monophosphokinase FDZ14_34645 ENOG4105E80 TraG TraD family protein FDZ14_34695 ENOG4108HGU Histidine kinase FDZ14_34700 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FDZ14_34760 ENOG4106ANW SMI1_KNR4 FDZ14_34770 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FDZ14_34795 ENOG4107RB3 L-asparaginase FDZ14_34815 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FDZ14_34825 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FDZ14_34860 ENOG4105DZR Type I site-specific deoxyribonuclease FDZ14_34880 ENOG4108Z66 YbaK ebsC protein FDZ14_34885 ENOG4108PCN EamA-like transporter family FDZ14_34890 ENOG4108JCI Transcriptional regulator FDZ14_34895 ENOG4105EKQ RNA-directed DNA polymerase FDZ14_34900 ENOG4105DDN Pentapeptide repeat-containing protein FDZ14_34905 ENOG4105EKQ RNA-directed DNA polymerase FDZ14_34955 ENOG4105CIB oxidoreductase Domain protein FDZ14_34965 ENOG4105C54 Major Facilitator superfamily FDZ14_34970 ENOG4105ETE Transcriptional regulator (LacI family FDZ14_34975 ENOG4107QNK )-transporter FDZ14_34985 ENOG4105CID antiterminator FDZ14_34990 ENOG4105C5Y PTS System FDZ14_34995 ENOG4105CS2 ec 3.2.1.21 FDZ14_35005 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FDZ14_35010 ENOG41063ZK Transcriptional Regulator AraC Family FDZ14_35020 ENOG4105EQ0 Major Facilitator superfamily FDZ14_35035 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDZ14_35040 ENOG4105N80 Ferric uptake regulator, Fur family FDZ14_35055 ENOG4105CPC Aldo Keto reductase FDZ14_35070 ENOG4105CI2 imidazolone-5-propionate hydrolase FDZ14_35080 ENOG4105ERH Fumarylacetoacetate hydrolase FDZ14_35090 ENOG4108QBF Transcriptional regulator FDZ14_35095 ENOG4108QBF Transcriptional regulator FDZ14_35105 ENOG4108TKH Nitroreductase FDZ14_35115 ENOG4108JUB Transcriptional regulator FDZ14_35140 ENOG4105EA8 2-Nitropropane dioxygenase FDZ14_35160 ENOG4105EA8 2-Nitropropane dioxygenase FDZ14_35170 ENOG4105KVH Transcriptional regulator FDZ14_35175 ENOG4105DEN Luciferase family FDZ14_35210 ENOG4108MTT Glutamate-rich protein grpB FDZ14_35330 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FDZ14_35355 ENOG4105YWU small acid-soluble spore protein FDZ14_35365 ENOG4105CNU cell division protein FtsK FDZ14_35410 ENOG4105BZU Histidine kinase FDZ14_35490 ENOG4105K4H Nlp p60 protein FDZ14_35550 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)