locus-tag class description BG04_10 ENOG4105HDK L-asparaginase BG04_1000 ENOG4108U5N UPF0316 protein BG04_1001 ENOG4107QIV Cytochrome c biogenesis protein BG04_1003 ENOG4105BZ1 (ABC) transporter BG04_1004 ENOG4105BZ1 (ABC) transporter BG04_1005 ENOG4105VXM UPF0154 protein BG04_1008 ENOG4105VPS UPF0291 protein BG04_1009 ENOG4108SVB resolvase BG04_1011 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BG04_1013 ENOG41076HS cation diffusion facilitator family transporter BG04_1014 ENOG4105C0X amino acid BG04_1016 ENOG4105C5F glutamine synthetase BG04_1017 ENOG4105KV4 Transcriptional regulator BG04_1018 ENOG4105CXI aluminum resistance protein BG04_1019 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BG04_1020 ENOG4105EN6 Membrane BG04_1021 ENOG4106F1P AAA ATPase, central domain protein BG04_1023 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BG04_1024 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BG04_1025 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BG04_1026 ENOG4105CUB amino acid BG04_1029 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BG04_1030 ENOG4105DQU oxidoreductase, subunit beta BG04_1031 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BG04_1033 ENOG4105MCT stage V sporulation protein S BG04_1034 ENOG4105D48 metallophosphoesterase BG04_1036 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BG04_1037 ENOG4105CEV competence damage-inducible protein BG04_1038 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BG04_1041 ENOG4105XZV Protein of unknown function (DUF3243) BG04_1042 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BG04_1046 ENOG4105UIB (ABC) transporter BG04_1047 ENOG4108JQ9 ABC transporter BG04_1048 ENOG4105DIH basic membrane BG04_1049 ENOG4105FDP GntR family transcriptional regulator BG04_105 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BG04_1050 ENOG4105CNU cell division protein FtsK BG04_1052 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BG04_1054 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG04_1056 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BG04_1057 ENOG4108S0H Dipicolinic acid synthetase, b subunit BG04_1058 ENOG4105E35 Dipicolinate synthase subunit A BG04_106 ENOG4105Y7M Transcriptional regulator, TetR family BG04_1060 ENOG4105C1V Peptidase, M16 BG04_1062 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BG04_1063 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BG04_1064 ENOG4105DTN riboflavin biosynthesis protein ribF BG04_1067 ENOG4105W7A Protein of unknown function (DUF503) BG04_1068 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BG04_1069 ENOG4105VHM ribosomal protein BG04_107 ENOG410814C multidrug resistance protein BG04_1070 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BG04_1071 ENOG4105CHV Transcription elongation factor NusA BG04_1072 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BG04_1073 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BG04_1074 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BG04_1075 ENOG4105DZP Membrane-associated zinc metalloprotease BG04_1076 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BG04_1077 ENOG4105KNE Phosphatidate cytidylyltransferase BG04_1078 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BG04_1079 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BG04_108 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BG04_1081 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BG04_1082 ENOG4105CE9 30S ribosomal protein S2 BG04_1084 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG04_1085 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BG04_1086 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BG04_1087 ENOG4105CBS Chea signal transduction histidine kinase BG04_1088 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BG04_109 ENOG4105VEQ Cold shock protein BG04_1090 ENOG4105FZW flagellar biosynthesis regulator FlhF BG04_1091 ENOG4105D7B Flagellar biosynthesis protein flha BG04_1092 ENOG4105D00 flagellar biosynthetic protein flhB BG04_1093 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BG04_1094 ENOG4105VS8 Flagellar biosynthetic protein fliq BG04_1095 ENOG4105CN7 Flagellar biosynthetic protein FliP BG04_1097 ENOG4107YTP response regulator receiver protein BG04_1098 ENOG4105DD5 Flagellar motor switch protein BG04_1099 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BG04_11 ENOG4108IMY Transcriptional regulator BG04_110 ENOG4108QY0 Membrane BG04_1101 ENOG41068WV flagellar FlbD family protein BG04_1102 ENOG4108JQA flagellar BG04_1103 ENOG410822I Flagellar hook capping protein BG04_1106 ENOG4106YF4 Flagellar biosynthesis chaperone BG04_1109 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BG04_1110 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BG04_1111 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BG04_1112 ENOG4108ZC9 flagellar basal-body rod protein flgc BG04_1113 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BG04_1114 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) BG04_1115 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BG04_1116 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BG04_1117 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BG04_1118 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BG04_1119 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BG04_1120 ENOG4105C79 DNA protecting protein DprA BG04_1121 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BG04_1122 ENOG4105CMV Succinyl-CoA synthetase subunit beta BG04_1126 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BG04_1128 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BG04_113 ENOG4108RYK Nad-dependent epimerase dehydratase BG04_1130 ENOG4105VB6 UPF0109 protein BG04_1131 ENOG4105K5M 30s ribosomal protein S16 BG04_1134 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BG04_1135 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BG04_1136 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BG04_1137 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BG04_1138 ENOG4105CHR reductase BG04_1139 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BG04_1140 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BG04_1141 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BG04_1142 ENOG4105CB5 ATP-dependent DNA helicase recG BG04_1143 ENOG4105EJQ L-serine dehydratase BG04_1146 ENOG4105DP4 dak2 domain fusion protein ylov BG04_1147 ENOG4108ZAA Alkaline-shock protein BG04_1148 ENOG4105VB9 50S ribosomal protein l28 BG04_1149 ENOG4105FJ0 thiamine BG04_1150 ENOG4105DJV ribulose-phosphate 3-epimerase BG04_1151 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BG04_1152 ENOG4105D9P serine threonine protein kinase BG04_1153 ENOG4108ZF3 Phosphatase BG04_1154 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BG04_1155 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BG04_1156 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BG04_1158 ENOG4105C25 Primosomal protein n' BG04_1159 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BG04_1161 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BG04_1162 ENOG4105KC4 UPF0296 protein BG04_1166 ENOG4105F23 Fibronectin-binding protein BG04_1167 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BG04_1170 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BG04_1173 ENOG4105CD3 dihydroorotase BG04_1174 ENOG4105CXT aspartate transcarbamylase BG04_1176 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BG04_1177 ENOG4105C34 Pseudouridine synthase BG04_1178 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BG04_118 ENOG4105WEF catalase BG04_1182 ENOG4105DBK s4 domain protein BG04_1183 ENOG41067XK integral membrane protein BG04_1184 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BG04_1185 ENOG4105DFA alanine racemase domain protein BG04_1186 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BG04_1187 ENOG4105WR5 sporulation protein, YlmC YmxH family BG04_1189 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG04_1190 ENOG4108AWX Sporulation factor SpoIIGA BG04_1191 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BG04_1192 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BG04_1193 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BG04_1194 ENOG4105D4A Cell wall formation (By similarity) BG04_1195 ENOG4105CNI cell division protein FtsW BG04_1196 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BG04_1197 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BG04_1198 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BG04_1199 ENOG4105CJN penicillin-binding protein BG04_120 ENOG4108IPW abc transporter atp-binding protein BG04_1200 ENOG4105CJN penicillin-binding protein BG04_1201 ENOG41068DC Essential cell division protein (By similarity) BG04_1203 ENOG41074B2 UPF0747 protein BG04_1206 ENOG4107QX3 carboxylase BG04_1207 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BG04_1208 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BG04_1209 ENOG4108YG3 N-acetyltransferase BG04_121 ENOG4105CM4 permease protein BG04_1211 ENOG4105E39 Enoyl-CoA hydratase BG04_1212 ENOG41067VY 50S ribosomal protein L32 BG04_1213 ENOG4105KNH Nucleic acid-binding protein BG04_1214 ENOG4105CDE UPF0348 protein BG04_1215 ENOG41063PX domain protein BG04_1216 ENOG4105D78 K07001 NTE family protein BG04_1217 ENOG4105H20 Sporulation integral membrane protein YlbJ BG04_1218 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BG04_1219 ENOG4106H78 methyltransferase BG04_122 ENOG4105DHS permease protein BG04_1221 ENOG4105WUC UPF0298 protein BG04_1228 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BG04_1229 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BG04_123 ENOG4105F0V Cell wall hydrolase BG04_1230 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BG04_1232 ENOG4108SXZ UPF0302 protein BG04_1233 ENOG41068YB TPR repeat-containing protein BG04_1234 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BG04_1236 ENOG4105CIH Imidazole acetol-phosphate transaminase BG04_1237 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BG04_1239 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BG04_1240 ENOG4105DK0 Indole-3-glycerol phosphate synthase BG04_1241 ENOG4108I0Q anthranilate phosphoribosyltransferase BG04_1243 ENOG4105D49 3-dehydroquinate synthase BG04_1244 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BG04_1245 ENOG4105BZU Histidine kinase BG04_1246 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BG04_1247 ENOG4105EAH synthase BG04_1248 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BG04_1249 ENOG4105XXQ heptaprenyl diphosphate synthase component I BG04_1250 ENOG4105WP2 Tryptophan RNA-binding attenuator protein BG04_1251 ENOG4105EUJ GTP cyclohydrolase i BG04_1252 ENOG4105K70 DNA-binding protein BG04_1253 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BG04_1256 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BG04_1261 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BG04_1262 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BG04_1263 ENOG4105E9Q Acyl-transferase BG04_1264 ENOG4105CAT Cytidine monophosphate kinase BG04_1267 ENOG4105MSI germination protein ypeb BG04_1268 ENOG4105F0V Cell wall hydrolase BG04_1270 ENOG4107RB3 L-asparaginase BG04_1271 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BG04_1273 ENOG4108S6Z Negative regulator of genetic competence BG04_1274 ENOG4108XDN Transcriptional regulator BG04_1275 ENOG4107RGJ metallophosphoesterase BG04_1278 ENOG4105I7S Abortive infection protein BG04_1279 ENOG4105C9U ATP-dependent DNA helicase RecQ BG04_128 ENOG4105CPQ Dehydrogenase BG04_1282 ENOG4108SAX Membrane BG04_1283 ENOG4108JQ1 Dehydrogenase BG04_1284 ENOG4105DR5 peptidase BG04_1285 ENOG4105BZU Histidine kinase BG04_1286 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG04_1287 ENOG4105CRE cytochrome C BG04_1288 ENOG4107TWT Cytochrome c biogenesis protein BG04_1289 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG04_129 ENOG4105DT3 PTS system, galactitol-specific IIc component BG04_1290 ENOG4105FE9 pseudouridine synthase BG04_1292 ENOG4108JIC nucleoside recognition domain protein BG04_1293 ENOG4105DZ1 carboxypeptidase BG04_1294 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BG04_1295 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BG04_1298 ENOG4107ZE5 PPIases accelerate the folding of proteins BG04_1299 ENOG4105PTM secreted protein BG04_130 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) BG04_1302 ENOG4105G6R Stage v sporulation protein ae BG04_1304 ENOG4105CZ3 stage V sporulation protein ad BG04_1305 ENOG41090VF Stage v sporulation protein ac BG04_1308 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG04_1309 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BG04_131 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) BG04_1310 ENOG41082AN stage II sporulation protein BG04_1311 ENOG4105DZ1 carboxypeptidase BG04_1314 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BG04_1316 ENOG4105I3K Ferric uptake regulator, Fur family BG04_1317 ENOG4105MZ9 stage II sporulation protein m BG04_1318 ENOG4108YZ4 nudix hydrolase BG04_1320 ENOG4105CPC Aldo Keto reductase BG04_1322 ENOG4108IIH CoA-transferase subunit B BG04_1323 ENOG4105D6N CoA-transferase, subunit a BG04_1324 ENOG4105CHU acetyl-coa acetyltransferase BG04_1325 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BG04_1329 ENOG4108IXY short-chain dehydrogenase reductase BG04_1330 ENOG41069FQ Metallo-beta-lactamase superfamily BG04_1331 ENOG4105II7 pyrroline-5-carboxylate reductase BG04_1332 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BG04_1333 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BG04_1334 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BG04_1335 ENOG4105C26 Dehydrogenase BG04_1336 ENOG4105G9B Transcriptional regulator BG04_134 ENOG4105NF4 modulator of drug activity BG04_1340 ENOG4107SJI Dehydrogenase BG04_1341 ENOG4105BZ8 glutamate synthase BG04_1342 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BG04_1343 ENOG4108HNZ carboxyl transferase BG04_1346 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BG04_1347 ENOG4108QEG Membrane BG04_1348 ENOG4105CDA abc transporter atp-binding protein BG04_1349 ENOG4105E5Q amino acid AbC transporter BG04_135 ENOG4105C3F Signal peptidase i BG04_1350 ENOG4108HW3 (ABC) transporter BG04_1351 ENOG4108Y6J UPF0403 protein BG04_1352 ENOG4105DJT lAO AO transport system ATPase BG04_1353 ENOG4105D5P Methylmalonyl-coA mutase BG04_1355 ENOG4105C7S Dehydrogenase BG04_1356 ENOG4105CPP Dehydrogenase, E1 component BG04_1360 ENOG4107RDP Dehydrogenase BG04_1362 ENOG4108JUB Transcriptional regulator BG04_1363 ENOG4106CCJ Protein of unknown function (DUF2627) BG04_1364 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BG04_1366 ENOG4105DUX Transporter BG04_1367 ENOG4107QQR Sporulation BG04_1368 ENOG4105S1Z Stage IV sporulation protein B BG04_1369 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BG04_1371 ENOG4105DX0 Hemolysin A BG04_1374 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BG04_1376 ENOG4105M7K Involved in the transcription termination process (By similarity) BG04_1377 ENOG4108ZSR alkaline shock protein BG04_1378 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BG04_1382 ENOG410644B Stage III sporulation protein af BG04_1384 ENOG4105KQ4 Stage iii sporulation protein ad BG04_1385 ENOG4108CQH stage III sporulation protein AC BG04_1386 ENOG4105KR5 Stage iii sporulation protein BG04_1387 ENOG4105CD2 stage iii sporulation protein aa BG04_1389 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BG04_139 ENOG4105C98 muts2 protein BG04_1390 ENOG4105DC7 peptidase M24 BG04_1391 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BG04_1393 ENOG4105CBJ Metal-dependent enzyme BG04_1396 ENOG4105KST dependent repressor BG04_1397 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG04_1399 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BG04_14 ENOG4105CT4 transporter BG04_1400 ENOG4105WZW rhodanese family BG04_1402 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BG04_1403 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BG04_1404 ENOG4105C0D helicase BG04_141 ENOG4108UMN azlc family BG04_1411 ENOG4106855 Competence protein BG04_142 ENOG4108JCI Transcriptional regulator BG04_143 ENOG4108ZCF integral membrane protein BG04_1435 ENOG4105E4C Lytic transglycosylase catalytic BG04_1449 ENOG4108C66 Inherit from COG: DNA primase BG04_1452 ENOG4108TFU terminase (Small subunit) BG04_146 ENOG41062ES Transcriptional regulator BG04_1463 ENOG4108ZUE Phage regulatory protein rha BG04_1468 ENOG4106CVF DNA replication protein BG04_1483 ENOG410635T phage-like element pbsx protein BG04_1487 ENOG4108C33 Resolvase BG04_1490 ENOG4105C5X domain protein BG04_1493 ENOG4105DKQ ROK family BG04_1495 ENOG4107ZXI Rhomboid family BG04_1498 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BG04_1499 ENOG410861F 50S ribosomal protein L33 BG04_15 ENOG4105WAB arsR family transcriptional regulator BG04_150 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth BG04_1503 ENOG4108UTW Plays a role in the regulation of phosphate uptake BG04_1504 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BG04_1505 ENOG4107RF6 penicillin-binding protein BG04_1513 ENOG4105SXS Protein of unknown function (DUF456) BG04_1516 ENOG4107RCC Major Facilitator Superfamily BG04_1518 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BG04_1519 ENOG41063Y9 BG04_1520 ENOG4108U5J '-nucleotidase BG04_1521 ENOG4105N80 Ferric uptake regulator, Fur family BG04_1522 ENOG4105FAV ABC, transporter BG04_1523 ENOG4105FDK ABC transporter BG04_1525 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BG04_1528 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BG04_1529 ENOG4105EGD dinuclear metal center protein, YbgI family BG04_1532 ENOG4105C1G acyl-Coa dehydrogenase BG04_1533 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG04_1534 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BG04_1535 ENOG4107XJU UPF0178 protein BG04_1536 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BG04_1538 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BG04_1540 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BG04_1541 ENOG4105KG3 cytidine deaminase BG04_1542 ENOG4107YR5 Diacylglycerol kinase BG04_1543 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BG04_1544 ENOG4105CTJ Metal Dependent Phosphohydrolase BG04_1545 ENOG4105C9A Phoh family BG04_1547 ENOG41068P3 sporulation protein YqfC BG04_155 ENOG4107ETC gas vesicle protein BG04_1550 ENOG4105F7J membrane-bound serine protease BG04_1551 ENOG4105KTH gatB Yqey BG04_1553 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BG04_1554 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BG04_1555 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BG04_1556 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BG04_1558 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BG04_1559 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BG04_156 ENOG4108XNA Gas vesicle BG04_1560 ENOG4105CSA Coproporphyrinogen iii oxidase BG04_1561 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BG04_1564 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BG04_1565 ENOG4105TQK DNA polymerase iii, delta' subunit BG04_1567 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BG04_1568 ENOG4108UK2 deaminase BG04_1569 ENOG4105KQC Competence protein BG04_157 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) BG04_1571 ENOG4105DXX methyltransferase BG04_1572 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BG04_1573 ENOG4108WF2 Metal Dependent Phosphohydrolase BG04_1574 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BG04_1575 ENOG410812S Rna-binding protein BG04_1576 ENOG4105E2X shikimate dehydrogenase BG04_1577 ENOG4105CQW ribosome biogenesis GTPase YqeH BG04_1578 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BG04_1580 ENOG4105DJ4 phosphatidylserine decarboxylase BG04_1581 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BG04_1583 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG04_1586 ENOG4105C28 cystathionine BG04_1588 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BG04_1589 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BG04_1592 ENOG4107XRG penicillin-binding protein BG04_1593 ENOG4105D3W isochorismatase BG04_1594 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BG04_1595 ENOG4105DBI uridine monophosphokinase BG04_1596 ENOG4105CFP Peptidase U32 BG04_1597 ENOG4105XYU peptidase (U32 family) BG04_1598 ENOG4108VQJ O-methyltransferase BG04_1599 ENOG4105HHA aminodeoxychorismate lyase BG04_1600 ENOG4105VPH UPF0473 protein BG04_1602 ENOG4105VBH UPF0297 protein BG04_1603 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BG04_1604 ENOG4105C02 permease BG04_1606 ENOG41060CR BG04_1607 ENOG4105C7H Helicase, RecD TraA family BG04_1609 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BG04_161 ENOG4105NAE bifunctional deaminase-reductase domain protein BG04_1610 ENOG4105C3J Cysteine desulfurase BG04_1612 ENOG4105D1H recombination factor protein RarA BG04_1613 ENOG4105E2Z phosphate ABC transporter (Permease BG04_1614 ENOG4105C8U phosphate abc transporter BG04_1615 ENOG4105CVA phosphate BG04_1616 ENOG4105CUZ uba thif-type nad fad binding protein BG04_1618 ENOG4105C9M aspartyl-trna synthetase BG04_1619 ENOG4105CUT histidyl-tRNA synthetase BG04_1621 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BG04_1622 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BG04_1623 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BG04_1624 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BG04_1625 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BG04_1626 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BG04_1628 ENOG4105CKP Polysaccharide Biosynthesis Protein BG04_1629 ENOG4108QG2 Membrane BG04_163 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BG04_1630 ENOG4105NAP BG04_1631 ENOG4105VIE preprotein translocase, subunit YajC BG04_1632 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BG04_1633 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BG04_1634 ENOG41061AI Protein of unknown function (DUF2905) BG04_1635 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BG04_1636 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BG04_164 ENOG41067SE Tetr family transcriptional regulator BG04_1641 ENOG4106678 morphogenetic protein associated with SpoVID BG04_1642 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BG04_1643 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BG04_1644 ENOG4108IYU L-aspartate oxidase BG04_1647 ENOG4105CQC Prephenate dehydratase BG04_1648 ENOG41090I5 UPF0735 ACT domain-containing protein BG04_1649 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BG04_1651 ENOG4105K46 50S ribosomal protein l27 BG04_1652 ENOG4105X36 (ribosomal) protein BG04_1654 ENOG4105C03 ribonuclease BG04_1657 ENOG4107QMS site-determining protein BG04_1658 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BG04_1659 ENOG4105YHC Rod shape-determining protein MreD BG04_166 ENOG4105WEF catalase BG04_1660 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BG04_1661 ENOG4105DFF Rod shape-determining protein mreb BG04_1662 ENOG4105W5Q DNA repair protein (RadC BG04_1663 ENOG4108Z03 MAF-like protein BG04_1665 ENOG4106A3R peptidase BG04_1667 ENOG4108SJC Membrane BG04_1668 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BG04_1669 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BG04_1670 ENOG4106AR7 Spore coat protein BG04_1671 ENOG41068KH stage VI sporulation protein D BG04_1672 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BG04_1673 ENOG4105D52 delta-aminolevulinic acid dehydratase BG04_1675 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BG04_1677 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BG04_1679 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BG04_1680 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BG04_1681 ENOG4108IUQ atp-dependent protease BG04_1682 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BG04_1683 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BG04_1685 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BG04_1686 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BG04_1688 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BG04_1689 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BG04_1690 ENOG4108ZP8 Acetolactate synthase small subunit BG04_1691 ENOG4105C7K acetolactate synthase BG04_1693 ENOG4105M59 Phosphodiesterase, mj0936 family BG04_1696 ENOG4108XJQ germination protein BG04_1697 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BG04_1698 ENOG41067TZ transcriptional regulator, MarR family BG04_1699 ENOG4108QCI YvbH-like oligomerisation region BG04_170 ENOG4105N14 lysine exporter protein LysE YggA BG04_1700 ENOG4105CJ3 phosphate transporter BG04_1701 ENOG4107GRR phosphate transport regulator BG04_1702 ENOG4107RVG penicillin-binding protein BG04_1704 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BG04_1705 ENOG4108UZX fmn reductase BG04_1706 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BG04_1707 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BG04_1708 ENOG4105D7T ABC transporter BG04_1709 ENOG4107S91 Sodium hydrogen exchanger BG04_171 ENOG4106AXJ AraC family transcriptional regulator BG04_1710 ENOG4105NCW Trka-c domain protein BG04_1712 ENOG4105PFC Transcriptional regulator BG04_1714 ENOG4105E33 succinate dehydrogenase BG04_1716 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BG04_1718 ENOG4105CFH Aspartokinase BG04_172 ENOG4105BZU Histidine kinase BG04_1720 ENOG4105K63 Thioredoxin BG04_1721 ENOG4105C10 Electron transfer flavoprotein BG04_1722 ENOG4105BZJ Electron transfer flavoprotein BG04_1723 ENOG41060WC Enoyl-CoA hydratase BG04_1724 ENOG4107Z3H Transcriptional regulator, TetR family BG04_1725 ENOG4105CEY Amp-dependent synthetase and ligase BG04_1728 ENOG4105C98 muts2 protein BG04_1729 ENOG4105DCG PHP domain protein BG04_1731 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BG04_1732 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BG04_1733 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BG04_1734 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BG04_1735 ENOG4108RWN rrna methyltransferase BG04_1736 ENOG41067MF small acid-soluble spore protein BG04_1737 ENOG4105CN9 Peptidase m42 family protein BG04_174 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BG04_1741 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BG04_1742 ENOG4105VJV 50s ribosomal protein L35 BG04_1743 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BG04_1744 ENOG4105C22 threonyL-tRNA synthetase BG04_1745 ENOG4108TDW sporulation protein YtxC BG04_1748 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BG04_1750 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BG04_1751 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BG04_1754 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BG04_1755 ENOG4105C2M dna polymerase I BG04_1756 ENOG4105BZU Histidine kinase BG04_1757 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG04_1759 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BG04_1760 ENOG4108HMX isocitrate dehydrogenase (NADP) BG04_1761 ENOG4105BZN citrate synthase BG04_1762 ENOG4107CWS Protein of unknown function (DUF441) BG04_1763 ENOG4108REF Sporulation integral membrane protein ytvi BG04_1764 ENOG4105FS0 cytoplasmic membrane protein BG04_1765 ENOG4105CA9 Pyruvate kinase BG04_1766 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BG04_1767 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BG04_1768 ENOG4107YCY Transcriptional regulator BG04_1769 ENOG4105C6K Malic enzyme BG04_1770 ENOG4105C0B DNA polymerase III (alpha subunit) BG04_1771 ENOG4105VV2 BG04_1773 ENOG4105SFS phosphoesterase RecJ domain protein BG04_1777 ENOG4105E8R UPF0173 metal-dependent hydrolase BG04_1780 ENOG4105CH7 arginosuccinase BG04_1781 ENOG4105CDH Citrulline--aspartate ligase BG04_1784 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BG04_1786 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BG04_1787 ENOG4105KBJ sporulation protein ytfj BG04_1789 ENOG4105VK3 rdd domain containing protein BG04_1790 ENOG4105D07 Signal peptide peptidase, SppA BG04_1791 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BG04_1792 ENOG4105EFZ amidohydrolase BG04_1794 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BG04_1796 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) BG04_1797 ENOG4105U5Y Transcriptional regulator BG04_1798 ENOG4108W76 histidinol phosphate phosphatase hisj family BG04_1800 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BG04_1801 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BG04_1803 ENOG4105F1V Acetoin utilization protein BG04_1804 ENOG4105W87 Cbs domain BG04_1805 ENOG4105DGU Histone deacetylase BG04_1806 ENOG4106VK6 Flagellar motor protein BG04_1807 ENOG4105E14 MotA TolQ exbB proton channel BG04_1808 ENOG4105ETE Transcriptional regulator (LacI family BG04_1809 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BG04_181 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BG04_1814 ENOG4105DFU Cell wall formation (By similarity) BG04_1817 ENOG4108VDD TRNA binding domain protein BG04_1818 ENOG4108NKM UPF0354 protein BG04_1820 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BG04_1822 ENOG4105C8F Beta-lactamase domain protein BG04_1824 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BG04_1826 ENOG4108V15 phosphotransferase enzyme family BG04_1827 ENOG4108IUM Glycogen debranching enzyme BG04_1829 ENOG4107F58 2'-5' rna ligase BG04_1830 ENOG4105C6T cysteine synthase BG04_1831 ENOG4107QSE Dipeptidase BG04_1832 ENOG4105YW5 deoR family transcriptional regulator BG04_1835 ENOG4105CBX hi0933 family BG04_1837 ENOG41085GJ domain protein BG04_1838 ENOG4105C8T Leucyl-tRNA synthetase BG04_184 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BG04_1840 ENOG4105CY2 Citrate transporter BG04_1841 ENOG410605W Major Facilitator BG04_1844 ENOG4105N5T Radical SAM Protein BG04_1847 ENOG4105E8V Alpha Beta Hydrolase Fold protein BG04_1849 ENOG4108Z0R Transferase BG04_1850 ENOG4105YVM Phosphoesterase, PA-phosphatase related BG04_1851 ENOG4105BZF Glycosyl transferase (Group 1 BG04_1852 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BG04_1853 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BG04_1856 ENOG4105D2X ABC transporter substrate-binding protein BG04_1858 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BG04_1862 ENOG4108RMU ferritin dps family protein BG04_1863 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BG04_1864 ENOG4108V2W Carbonate dehydratase BG04_1865 ENOG4105CKI cobalamin synthesis protein BG04_1867 ENOG4105NRA 50s ribosomal protein l31 type b BG04_187 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BG04_1870 ENOG4105NQC Flavodoxin BG04_1874 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG04_1875 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BG04_1876 ENOG4105DTQ mandelate racemase muconate lactonizing BG04_1877 ENOG4105CEY Amp-dependent synthetase and ligase BG04_1878 ENOG4108IPT Naphthoate synthase BG04_1879 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BG04_188 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BG04_1880 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BG04_1881 ENOG4105E4F Isochorismate synthase BG04_1885 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BG04_1887 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BG04_189 ENOG4105BZU Histidine kinase BG04_19 ENOG4107QTZ amino acid BG04_190 ENOG4105EFI regulatoR BG04_191 ENOG4105JAB phenazine biosynthesis protein, phzf family BG04_1912 ENOG4105CEY Amp-dependent synthetase and ligase BG04_1913 ENOG4105KT7 mgtC SapB transporter BG04_1914 ENOG4108Z73 Siroheme synthase BG04_1915 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BG04_1916 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BG04_1917 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BG04_1923 ENOG4107PBV potassium channel BG04_1925 ENOG4107QYV phosphohexose isomerase BG04_1927 ENOG4105D65 subunit l BG04_1928 ENOG4105HC0 Na H antiporter BG04_1929 ENOG4108ZE9 Monovalent cation H antiporter subunit C BG04_1930 ENOG4108JPZ Monovalent cation H antiporter subunit D BG04_1931 ENOG4105SC1 monovalent cation H antiporter subunit E BG04_1933 ENOG4105KJM monovalent cation h antiporter subunit g BG04_1934 ENOG4107QW4 alcohol dehydrogenase BG04_1935 ENOG4105WG9 Conserved Protein BG04_1937 ENOG4105CHM Aminotransferase BG04_1938 ENOG4108ZB6 transcriptional regulator AsnC family BG04_1939 ENOG4108MUZ hydrolase BG04_194 ENOG4105BZU Histidine kinase BG04_1940 ENOG4105C87 Aminotransferase class I and II BG04_1941 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BG04_1943 ENOG4105Y38 Kinase-associated protein B BG04_1945 ENOG4105KA0 thioesterase Superfamily protein BG04_195 ENOG4105D9U N-acetyltransferase BG04_1950 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BG04_1952 ENOG41069ER domain protein BG04_1954 ENOG4105CEP NADH dehydrogenase BG04_1957 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BG04_1958 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BG04_1959 ENOG4105ZKE UPF0349 protein BG04_196 ENOG4105MWK D-amino acid dehydrogenase, small subunit BG04_1962 ENOG41083MR nifu domain-containing protein BG04_1963 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BG04_1964 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BG04_1965 ENOG4105D6E homoserine dehydrogenase BG04_1966 ENOG4105C5I Dehydrogenase BG04_1968 ENOG4108W5N phosphatidylglycerophosphatase a BG04_1969 ENOG4105D4U had-superfamily hydrolase, subfamily iia BG04_1972 ENOG4105MMD transcriptional regulator BG04_1973 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BG04_1974 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BG04_1975 ENOG4105FAA peptidase M23 BG04_1977 ENOG4105C8J )-transporter BG04_1978 ENOG4108YTE sporulation protein YunB BG04_1979 ENOG4105KZD Domain of unknown function (DUF1805) BG04_1980 ENOG4105I3N Conserved Protein BG04_1981 ENOG4105DIW FeS assembly protein SUFB BG04_1982 ENOG4108UNV SUF system FeS assembly protein, NifU family BG04_1983 ENOG4105C9B Cysteine desulfurase BG04_1984 ENOG4105JRK feS assembly protein SufD BG04_1985 ENOG4105C3K feS assembly ATPase SufC BG04_1987 ENOG4105D01 (LipO)protein BG04_1988 ENOG4108UMI ABC transporter, permease BG04_1989 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BG04_1993 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BG04_1994 ENOG41080E8 Transcriptional regulator, Spx MgsR family BG04_1995 ENOG4105C1G acyl-Coa dehydrogenase BG04_1996 ENOG4105CHU acetyl-coa acetyltransferase BG04_20 ENOG4108Z40 Transcriptional regulator BG04_2002 ENOG4105E0A ABC, transporter BG04_2003 ENOG4108IHU transport system permease protein BG04_2004 ENOG4105DQ5 transport system permease protein BG04_2005 ENOG4108MES Periplasmic binding protein BG04_2009 ENOG41067SE Tetr family transcriptional regulator BG04_2011 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BG04_2012 ENOG41079KZ Major Facilitator Superfamily BG04_2013 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BG04_2014 ENOG4105CMU LysR family (Transcriptional regulator BG04_2016 ENOG41062D9 Histidine kinase BG04_2017 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG04_2019 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BG04_202 ENOG4107QM2 Aldo Keto reductase BG04_2020 ENOG4105FS7 Transcriptional regulator BG04_2021 ENOG4108TVJ Nitroreductase BG04_2022 ENOG41067WU Molybdopterin converting factor (Subunit 1) BG04_2023 ENOG4108ZAF Molybdopterin BG04_2024 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BG04_2025 ENOG4105CVM Molybdenum cofactor synthesis domain protein BG04_2026 ENOG4105D06 uba thif-type nad fad binding protein BG04_2027 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BG04_2029 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BG04_2030 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BG04_2031 ENOG4108JB9 formate dehydrogenase BG04_2033 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BG04_2034 ENOG4105E0C molybdate abc transporter BG04_2035 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BG04_2036 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BG04_2038 ENOG4105XZU Preprotein translocase, subunit SecG BG04_204 ENOG4108UZ3 Transporter BG04_2046 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG04_2049 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BG04_205 ENOG4108MCI Transcriptional regulator, ARAC family BG04_2050 ENOG4105KRI phosphocarrier protein (HPr BG04_2052 ENOG4105CHW UPF0052 protein BG04_2053 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BG04_2054 ENOG4108Z4K mutator MutT protein BG04_2055 ENOG4105C3M thioredoxin reductase BG04_2057 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BG04_2058 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BG04_2059 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BG04_2060 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BG04_2061 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BG04_2062 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BG04_2063 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BG04_2064 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BG04_2065 ENOG4108S4C acetyltransferase BG04_2066 ENOG4107XGZ Hydrolase BG04_2067 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BG04_2068 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BG04_2069 ENOG41086DT Membrane protein of unknown function BG04_2070 ENOG41067S9 phage shock protein C, PspC BG04_2071 ENOG4108PY7 BG04_2073 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BG04_2074 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BG04_2075 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BG04_2076 ENOG4105C26 Dehydrogenase BG04_208 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) BG04_2080 ENOG4105CN1 protease BG04_2081 ENOG4105DR5 peptidase BG04_2082 ENOG4105CRP Part of the ABC transporter FtsEX involved in BG04_2083 ENOG4105CAK Cell division ATP-binding protein ftsE BG04_2084 ENOG4108WS4 fmn reductase BG04_2086 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BG04_2087 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BG04_2088 ENOG4105DGI Alkaline phosphatase BG04_2089 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BG04_2090 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BG04_2091 ENOG4105SUU thioesterase domain BG04_2092 ENOG4105MS2 ribosomal subunit Interface protein BG04_2094 ENOG4105MQ3 flagellar protein FliS BG04_2095 ENOG4107RT6 flagellar hook-associated BG04_2097 ENOG4105C85 amino acid BG04_2099 ENOG4105C26 Dehydrogenase BG04_210 ENOG4107ETC gas vesicle protein BG04_2100 ENOG4108JB8 alcohol dehydrogenase BG04_2101 ENOG4105TRT Transcriptional regulator BG04_2102 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BG04_2103 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BG04_2104 ENOG4105DTJ flagellar hook-associated protein BG04_2105 ENOG4105E1Q flagellar hook-associated protein BG04_2109 ENOG41081UC Inherit from COG: Competence protein BG04_2112 ENOG4105XVJ Protein of unknown function (DUF327) BG04_2114 ENOG4105WH1 Two component transcriptional regulator luxr family BG04_2115 ENOG4105BZU Histidine kinase BG04_2116 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BG04_2117 ENOG4108KGH TRANSCRIPTIONal BG04_2118 ENOG4105ESV Glycosyl transferase, family 4 BG04_2120 ENOG4105DZ6 Band 7 protein BG04_2123 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BG04_2125 ENOG4105C0D helicase BG04_2127 ENOG4105Z8H single-stranded DNA-binding protein BG04_2132 ENOG4105CGA flagellar basal-body rod protein FlgG BG04_2134 ENOG4105DFF Rod shape-determining protein mreb BG04_2135 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BG04_2136 ENOG4105FRN stage II sporulation protein BG04_2140 ENOG4106778 Protein of unknown function (DUF1146) BG04_2141 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BG04_2142 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BG04_2143 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BG04_2144 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BG04_2145 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BG04_2146 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) BG04_2147 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BG04_2148 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BG04_2149 ENOG41062M3 atp synthase BG04_2151 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BG04_2152 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BG04_2153 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BG04_2156 ENOG4108YZG isomerase BG04_2159 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BG04_216 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth BG04_2161 ENOG4108ZXQ stage ii sporulation protein r BG04_2162 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BG04_2163 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BG04_2165 ENOG4105VFB Binds the 23S rRNA (By similarity) BG04_2166 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BG04_2167 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BG04_2168 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BG04_2169 ENOG4105D2N Aldolase BG04_2170 ENOG410812K response regulator receiver protein BG04_2172 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BG04_2174 ENOG4105D5P Methylmalonyl-coA mutase BG04_2176 ENOG4105C1G acyl-Coa dehydrogenase BG04_2177 ENOG4105C1G acyl-Coa dehydrogenase BG04_2178 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BG04_2180 ENOG4105DF6 Fe-S oxidoreductase BG04_2182 ENOG4105E5J UV damage endonuclease BG04_2183 ENOG4105C75 arginyL-tRNA synthetase BG04_2184 ENOG410684U Domain of unknown function (DUF1934) BG04_2185 ENOG4105CYW agmatinase BG04_2186 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BG04_2187 ENOG4105BZ4 penicillin-binding protein BG04_2188 ENOG4108XFG YwhD family BG04_2189 ENOG4108Z4T Peptidase M50 BG04_219 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth BG04_2190 ENOG41069HH 4-oxalocrotonate tautomerase BG04_2192 ENOG4105DCI Phosphohydrolase BG04_2194 ENOG4108VCI transcription factor, rsfa family BG04_2196 ENOG4108IJ2 phosphate acetyltransferase BG04_2197 ENOG4107JTW chlorite dismutase BG04_2198 ENOG4108VKI Cell wall hydrolase BG04_220 ENOG4107KM7 Heat induced stress protein YflT BG04_2202 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BG04_2204 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BG04_2205 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BG04_2206 ENOG4108K8K Transcriptional regulator BG04_2207 ENOG4105DCF alanine dehydrogenase BG04_2209 ENOG4105DWF phosphomethylpyrimidine kinase BG04_2210 ENOG4105J7I hydrolase BG04_2211 ENOG4107URF beta-phospho-glucomutase BG04_2212 ENOG4105CI1 PTS System BG04_2214 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BG04_2217 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BG04_2219 ENOG4105CJR Integral membrane protein (MviN BG04_222 ENOG4105EGI Transcriptional regulator BG04_2222 ENOG4108JJ8 (ABC) transporter BG04_2223 ENOG4108JJ9 ABC, transporter BG04_2224 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BG04_2225 ENOG4105C4M (Ubiquinol oxidase) subunit I BG04_2226 ENOG4107XM3 UPF0442 protein BG04_2227 ENOG4105DWK Membrane BG04_2228 ENOG4105ETE Transcriptional regulator (LacI family BG04_223 ENOG41081I9 integral membrane protein BG04_2235 ENOG4105BZU Histidine kinase BG04_2238 ENOG4107QPK )-transporter BG04_2239 ENOG4105DR4 Methyltransferase BG04_2242 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BG04_2244 ENOG4105C0H protease BG04_2245 ENOG4105Q2H domain protein BG04_2248 ENOG4105BZU Histidine kinase BG04_2249 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG04_225 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BG04_2254 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BG04_2255 ENOG4105CDU Replicative dna helicase BG04_2257 ENOG4105BZR domain protein BG04_2259 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BG04_2260 ENOG4108UUM single-stranded DNA-binding protein BG04_2262 ENOG4105C3G gtp-binding protein BG04_2263 ENOG4105VDK protein, conserved in bacteria BG04_2264 ENOG4105D8X mechanosensitive ion channel BG04_2266 ENOG4108ZDA Sporulation protein YyaC BG04_2267 ENOG4105FA0 parb-like partition protein BG04_2268 ENOG4107QJE Chromosome Partitioning Protein BG04_2269 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) BG04_2271 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BG04_2272 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BG04_2274 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BG04_2275 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BG04_2276 ENOG4105VG0 50S ribosomal protein l34 BG04_2277 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BG04_2278 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BG04_2279 ENOG410848D S4 domain protein YaaA BG04_2281 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BG04_2282 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BG04_2289 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BG04_2291 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BG04_2292 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BG04_2295 ENOG4105ZMH deoxynucleoside kinase BG04_2297 ENOG4105VRS hydrolase family 18 BG04_2298 ENOG4105GTG Isochorismatase BG04_2299 ENOG4108Z6B deaminase BG04_230 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BG04_2300 ENOG4105C6E dna polymerase iii BG04_2301 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BG04_2302 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BG04_2304 ENOG41067KS pro-sigma K processing BG04_231 ENOG4105F6J Alpha beta hydrolase fold BG04_2323 ENOG4105CXN decarboxylase BG04_2324 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BG04_2325 ENOG4105X0R protein from nitrogen regulatory protein P-II BG04_2326 ENOG4105FA2 dna polymerase iii BG04_2327 ENOG4105MA4 psp1 domain protein BG04_2328 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) BG04_2329 ENOG41060K3 Methyltransferase BG04_233 ENOG4108IYU L-aspartate oxidase BG04_2330 ENOG4105VC4 domain protein BG04_2331 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BG04_2332 ENOG4105KRN Transcriptional regulator, abrb family BG04_2333 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BG04_2334 ENOG4105F8V Hydrolase, tatD family BG04_2335 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BG04_2336 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BG04_2337 ENOG4105XFA sporulation peptidase YabG BG04_2338 ENOG4105W42 Veg protein BG04_234 ENOG41079KZ Major Facilitator Superfamily BG04_2341 ENOG4105DFT pur operon repressor BG04_2342 ENOG4105KME endoribonuclease L-psp BG04_2343 ENOG4105K4W Could be involved in septation (By similarity) BG04_2344 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BG04_2345 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BG04_2346 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BG04_2347 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BG04_2349 ENOG4108JA2 transcriptioN-repair coupling factor BG04_235 ENOG4108MK9 spermidine N(1)-acetyltransferase BG04_2350 ENOG4108M14 stage v sporulation protein t BG04_2352 ENOG4108IY2 MazG family BG04_2353 ENOG41082I2 s4 domain protein BG04_2354 ENOG4105VYY sporulation protein yabp BG04_2357 ENOG41060GV RNA binding s1 domain protein BG04_2360 ENOG4105G3A stage ii sporulation protein e BG04_2363 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BG04_2364 ENOG4108UGV hypoxanthine phosphoribosyltransferase BG04_2365 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BG04_2366 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BG04_2367 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BG04_2368 ENOG4105C6T cysteine synthase BG04_2369 ENOG4105CRQ synthase (Component I) BG04_2370 ENOG4105DDQ anthranilate synthase BG04_2371 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BG04_2372 ENOG4105KRF dihydroneopterin aldolase BG04_2373 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BG04_2374 ENOG4105CRK lysyL-tRNA synthetase BG04_2379 ENOG4108Z0C Uvrb UvrC protein BG04_2380 ENOG41066A3 ATP guanido phosphotransferase BG04_2382 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BG04_2383 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BG04_2384 ENOG4105CTP PilT protein domain protein BG04_2385 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BG04_2386 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BG04_2387 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BG04_2388 ENOG4105D7W serine acetyltransferase BG04_2389 ENOG4105C8N cysteinyl-tRNA synthetase BG04_239 ENOG4105FBW Monooxygenase BG04_2391 ENOG4105C2N RNA methyltransferase TrmH family group 3 BG04_2392 ENOG4105M0M Tetracycline resistance protein BG04_2393 ENOG4105QIV RNA polymerase BG04_2394 ENOG41087NY 50S ribosomal protein L33 BG04_2396 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BG04_2398 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BG04_2399 ENOG4108VZM 50s ribosomal protein L10 BG04_24 ENOG4105C6K Malic enzyme BG04_240 ENOG4105C1G acyl-Coa dehydrogenase BG04_2400 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BG04_2401 ENOG4107Y49 methyltransferase BG04_2402 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BG04_2403 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BG04_2404 ENOG4105XPM ribosomal protein BG04_2405 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BG04_2406 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BG04_2408 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BG04_241 ENOG4105CPQ Dehydrogenase BG04_2410 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BG04_2411 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BG04_2412 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BG04_2413 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BG04_2414 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BG04_2415 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BG04_2416 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BG04_2417 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BG04_2418 ENOG41082SA 50s ribosomal protein l29 BG04_2419 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BG04_242 ENOG4105CJZ response regulator BG04_2420 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BG04_2423 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BG04_2424 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BG04_2425 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BG04_2427 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BG04_2428 ENOG4105VPB 50S ribosomal protein L30 BG04_2429 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BG04_243 ENOG4105EWM Histidine kinase BG04_2430 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BG04_2431 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BG04_2432 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BG04_2433 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BG04_2434 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BG04_2436 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BG04_2437 ENOG4108ZT0 50S ribosomal protein l17 BG04_2438 ENOG4108JJB ABC transporter BG04_2439 ENOG4108JJB ABC transporter BG04_244 ENOG4105C19 ABC transporter BG04_2440 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BG04_2441 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BG04_2442 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BG04_2446 ENOG4105D1F ATP-binding protein BG04_2447 ENOG4108KSA LysR family transcriptional regulator BG04_245 ENOG4108HVR ABC transporter, permease BG04_2450 ENOG4108NMV polysaccharide deacetylase BG04_2466 ENOG4105EMN RNA polymerase sigma factor BG04_2468 ENOG4105C8B TIGR00159 family BG04_2470 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BG04_2471 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BG04_2473 ENOG41068JE domain protein BG04_2474 ENOG4105CTS PTS system mannitol-specific BG04_2475 ENOG4105ETD TRANSCRIPTIONal BG04_2476 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BG04_2478 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BG04_2479 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BG04_248 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG04_2480 ENOG4107T7U Sulfatase BG04_2483 ENOG4105F38 ABC transporter, permease BG04_2484 ENOG4105D38 putrescine abc transporter BG04_2485 ENOG4107RUE extracellular solute-binding protein family 1 BG04_2487 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG04_2488 ENOG4105US7 Histidine kinase BG04_2490 ENOG41081YB ApbE family BG04_2491 ENOG4105I7V membrAne BG04_2492 ENOG4105CPF Cell wall formation (By similarity) BG04_2493 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BG04_2494 ENOG4105C1J atp-dependent rna helicase BG04_2497 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BG04_2498 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BG04_2499 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BG04_25 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BG04_250 ENOG41087NI Sulfite exporter TauE/SafE BG04_2501 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BG04_2502 ENOG4107MMM Anti-sigma-factor antagonist BG04_2503 ENOG4105FUA antagonist BG04_2504 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BG04_2505 ENOG4107SGM protein serine threonine phosphatase BG04_2506 ENOG4105WN5 stage II sporulation protein BG04_2509 ENOG41064BQ Phosphatase BG04_251 ENOG4105VFE sira family BG04_252 ENOG4107TPS domain protein BG04_2528 ENOG4105K8N protein family UPF0079, ATPase BG04_2529 ENOG41072GX Peptidase M22 Glycoprotease BG04_253 ENOG4105VFE sira family BG04_2530 ENOG410801F ribosomal-protein-alanine acetyltransferase BG04_2531 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BG04_2532 ENOG4105C5H ABC transporter BG04_2533 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BG04_2534 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BG04_2535 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BG04_2537 ENOG4108TYN CAAX amino terminal protease family protein BG04_2538 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BG04_2539 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BG04_2540 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BG04_2541 ENOG4107S2N Type III effector Hrp-dependent BG04_2542 ENOG4105C0A alcohol dehydrogenase BG04_2543 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG04_2544 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BG04_2548 ENOG4105CHR reductase BG04_2549 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BG04_2552 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BG04_2553 ENOG4105C7N Xanthine uracil vitamin C permease BG04_256 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BG04_2561 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BG04_2562 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BG04_2563 ENOG4105C83 adenylosuccinate lyase BG04_2564 ENOG4105C8V SAICAR synthetase BG04_2565 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BG04_2566 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BG04_2567 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BG04_2569 ENOG4105CXB phosphoribosylaminoimidazole synthetase BG04_257 ENOG4105VFE sira family BG04_2570 ENOG4108V3E phosphoribosylglycinamide formyltransferase BG04_2571 ENOG4105DC1 bifunctional purine biosynthesis protein purh BG04_2572 ENOG4105C12 Phosphoribosylglycinamide synthetase BG04_2575 ENOG4105KGF protein, YerC YecD BG04_2576 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BG04_2578 ENOG4105C4R Atp-dependent dna helicase BG04_2579 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BG04_258 ENOG4105XTG Pfam:DUF156 BG04_2582 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BG04_2583 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BG04_2584 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BG04_2585 ENOG4105CBD Diacylglycerol kinase BG04_2589 ENOG4107AYK membrAne BG04_2592 ENOG4107RMD Basic membrane lipoprotein BG04_2593 ENOG4105BZU Histidine kinase BG04_2594 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BG04_2595 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BG04_2597 ENOG4108Z5V transcriptional regulator, merr family BG04_2598 ENOG4105C2C drug resistance transporter, Bcr CflA BG04_2601 ENOG4105CDA abc transporter atp-binding protein BG04_2602 ENOG4105CT1 (ABC) transporter BG04_2603 ENOG4105EAD ABC transporter BG04_2604 ENOG4105DRP amino acid AbC transporter BG04_2606 ENOG4106BRA Membrane BG04_2609 ENOG41062D9 Histidine kinase BG04_2610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG04_2612 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG04_2616 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BG04_2617 ENOG4108ZHJ Organic hydroperoxide resistance protein BG04_2621 ENOG4107R7Y intracellular protease Pfpi family BG04_2622 ENOG4106DF1 BG04_2624 ENOG4105BZG amino acid carrier protein BG04_2628 ENOG4105D7N magnesium and cobalt transport protein CorA BG04_263 ENOG4105GZI Transcriptional regulator BG04_2630 ENOG4108MRH transcriptional regulatory protein BG04_2633 ENOG4105BZU Histidine kinase BG04_2634 ENOG4105FDU atp-dependent rna helicase BG04_2636 ENOG4108IBT Inherit from COG: transposase BG04_2645 ENOG4108K8S endonuclease I BG04_2647 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BG04_2650 ENOG4105C5H ABC transporter BG04_2651 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase BG04_2654 ENOG4105KPV Transcriptional regulator BG04_2655 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BG04_2656 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) BG04_2657 ENOG4108Z0Z intracellular protease Pfpi family BG04_2658 ENOG4105K4I Scp-like extracellular BG04_2659 ENOG4105CPN adenine deaminase BG04_2661 ENOG4105KJF protein tyrosine phosphatase BG04_2663 ENOG4107U9T Pfam:Ribonuclease_BN BG04_2665 ENOG4105C59 p-type ATPase BG04_2667 ENOG4105KTU Transcriptional regulator, arsr family BG04_2668 ENOG4105PGM cation diffusion facilitator family transporter BG04_2669 ENOG4108ISG Major Facilitator BG04_2670 ENOG4105PY6 Phenolic acid decarboxylase BG04_2674 ENOG4105UPD Calcium Proton BG04_268 ENOG4108S3Y transcriptional regulator BG04_2680 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BG04_2681 ENOG4105C85 amino acid BG04_2682 ENOG4105BZU Histidine kinase BG04_2686 ENOG4105ECP epimerase BG04_2688 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr BG04_2690 ENOG4105XHU Acid-soluble spore protein K BG04_2692 ENOG41067AE Membrane-bound metal-dependent hydrolase BG04_2693 ENOG4105CEN a g-specific adenine glycosylase BG04_2694 ENOG4106BXE BG04_2695 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BG04_2698 ENOG4105EVI UPF0374 protein BG04_2699 ENOG4105BZ1 (ABC) transporter BG04_27 ENOG41068WN BG04_270 ENOG4105CS2 ec 3.2.1.21 BG04_2700 ENOG4107NBY Membrane BG04_2701 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BG04_2702 ENOG4108IUW ABC transporter BG04_2706 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG04_2707 ENOG4105G5W regulator Fur family BG04_2708 ENOG4105TUA UPF0295 protein BG04_273 ENOG4105X3H Excalibur domain protein BG04_2731 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BG04_2733 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BG04_2735 ENOG4105CYN Serine protein kinase BG04_2736 ENOG4106AKX UPF0229 protein BG04_2738 ENOG41076HS cation diffusion facilitator family transporter BG04_2741 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BG04_2743 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BG04_2745 ENOG4108REF Sporulation integral membrane protein ytvi BG04_2746 ENOG4107T5V SNARE associated Golgi BG04_2747 ENOG4105EU9 BG04_2748 ENOG4105CUB amino acid BG04_2752 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BG04_2753 ENOG4108IJ9 (ABC) transporter BG04_2754 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component BG04_2755 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BG04_2757 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BG04_276 ENOG4105N14 lysine exporter protein LysE YggA BG04_2760 ENOG4105DTQ mandelate racemase muconate lactonizing BG04_2769 ENOG41069ER domain protein BG04_277 ENOG41080UX Methyltransferase BG04_2770 ENOG4108VXD carboxy-peptidase BG04_2774 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BG04_2775 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BG04_2778 ENOG4105YWU small acid-soluble spore protein BG04_2780 ENOG4105ETE Transcriptional regulator (LacI family BG04_2781 ENOG4105IE8 Alpha-ketoglutarate permease BG04_2782 ENOG4105CK5 oxidoreductase BG04_2787 ENOG4105ETE Transcriptional regulator (LacI family BG04_279 ENOG4107RSM transcriptional regulator BG04_2791 ENOG4108JYZ YitT family BG04_2796 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_2797 ENOG4105FE9 pseudouridine synthase BG04_2800 ENOG41090U3 tautomerase BG04_2801 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BG04_2804 ENOG4105D4T Citrate transporter BG04_2807 ENOG4108RE7 deoxyribonuclease BG04_2812 ENOG4105CB2 alcohol dehydrogenase BG04_2813 ENOG4105DAA L-lactate BG04_2814 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BG04_2816 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BG04_2817 ENOG4108YBP pseudouridine synthase BG04_2819 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BG04_282 ENOG4105BZU Histidine kinase BG04_2820 ENOG4108PXI ErfK YbiS YcfS YnhG BG04_2821 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BG04_2822 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BG04_2824 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BG04_2825 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BG04_2829 ENOG4105ED1 spovr family BG04_283 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BG04_2831 ENOG4108Z40 Transcriptional regulator BG04_2834 ENOG4105CDA abc transporter atp-binding protein BG04_2835 ENOG4105DRP amino acid AbC transporter BG04_2838 ENOG41082CG Protein CrcB homolog BG04_2840 ENOG4108VEU Thiamine monophosphate synthase BG04_2841 ENOG41080HI glycine oxidase BG04_2844 ENOG4105D06 uba thif-type nad fad binding protein BG04_2845 ENOG4105DWF phosphomethylpyrimidine kinase BG04_285 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BG04_2850 ENOG4105YWU small acid-soluble spore protein BG04_2856 ENOG410839P BG04_2859 ENOG4105WZB UPF0342 protein BG04_286 ENOG4108TVJ Nitroreductase BG04_2861 ENOG4105D4P Coproporphyrinogen iii oxidase BG04_2862 ENOG4105CEY Amp-dependent synthetase and ligase BG04_2863 ENOG4105CGU Enoyl-CoA hydratase BG04_2864 ENOG4105K70 DNA-binding protein BG04_2866 ENOG4108IUX (ABC) transporter BG04_2867 ENOG4105RHA ABC transporter, permease BG04_2868 ENOG4105EQI Metal Dependent Phosphohydrolase BG04_287 ENOG4105C26 Dehydrogenase BG04_2870 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BG04_2874 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) BG04_2876 ENOG4105NBU tryptophan transport protein BG04_2877 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BG04_2878 ENOG4105U3E Transcriptional regulator BG04_2879 ENOG4107YB6 acetyltransferase, (GNAT) family BG04_2880 ENOG4105EXC Acyl-transferase BG04_2881 ENOG4105K59 histidine triad (HIT) protein BG04_2886 ENOG410841Q phosphoesterase PA-phosphatase related protein BG04_2888 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BG04_2889 ENOG4105BZ4 penicillin-binding protein BG04_2890 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BG04_2891 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BG04_2892 ENOG4105C1Q protoporphyrinogen oxidase BG04_2894 ENOG4107RF6 penicillin-binding protein BG04_2896 ENOG4105C2F Histidine kinase BG04_2899 ENOG4108RQ5 Beta-lactamase domain-containing protein BG04_290 ENOG4108V0P LemA family BG04_2900 ENOG4105DF9 Lipoate-protein, ligase BG04_2901 ENOG4105CEY Amp-dependent synthetase and ligase BG04_2902 ENOG4105E39 Enoyl-CoA hydratase BG04_291 ENOG4108ZJ4 polysaccharide deacetylase BG04_2925 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BG04_2928 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BG04_2930 ENOG4105CHR reductase BG04_2932 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BG04_2934 ENOG4105EYH Exonuclease BG04_294 ENOG4105KVH Transcriptional regulator BG04_2945 ENOG4105CAQ asparagine synthetase BG04_2948 ENOG4105FE1 phytoene synthase BG04_2949 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BG04_295 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BG04_2950 ENOG4105FKQ transcriptional regulator BG04_2951 ENOG4105C26 Dehydrogenase BG04_2952 ENOG4105C8Y Acetylornithine aminotransferase BG04_2955 ENOG4108JUB Transcriptional regulator BG04_2956 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BG04_2957 ENOG4108VPT UPF0234 protein BG04_2958 ENOG4105QNR S1 RNA binding domain protein BG04_2959 ENOG4105EPR degv family BG04_296 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BG04_2960 ENOG4107AYK membrAne BG04_2963 ENOG4108KP7 hydrolase BG04_2964 ENOG4105VG1 fes assembly suf system protein BG04_2965 ENOG4107V6Q Cyclic nucleotide-binding domain BG04_2966 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BG04_2967 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BG04_2968 ENOG4105CAS nag kinase BG04_297 ENOG41068WN BG04_2972 ENOG4105DBV ornithine carbamoyltransferase BG04_2975 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BG04_2978 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BG04_2979 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BG04_2980 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BG04_2986 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BG04_2987 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BG04_2989 ENOG4105C3U ABC transporter BG04_2990 ENOG4108JQ7 (ABC) transporter BG04_2994 ENOG4108KU1 UPF0736 protein BG04_2995 ENOG4105C31 Tryptophanyl-tRNA synthetase BG04_2996 ENOG4108J59 Extracellular solute-binding protein, family 5 BG04_2997 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG04_2998 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG04_30 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BG04_3000 ENOG4108JQ7 (ABC) transporter BG04_3002 ENOG4105C85 amino acid BG04_3003 ENOG4105D5Q Arginine ornithine antiporter BG04_3004 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BG04_3005 ENOG4107RSM transcriptional regulator BG04_3008 ENOG4108ZCF integral membrane protein BG04_3010 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BG04_3012 ENOG4105DPN Oligoendopeptidase f BG04_3014 ENOG4105T58 Dithiol-disulfide isomerase BG04_3015 ENOG4108Z18 K06886 hemoglobin BG04_3016 ENOG4105E4C Lytic transglycosylase catalytic BG04_3017 ENOG4105MIX Adenylate cyclase BG04_3020 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BG04_3021 ENOG4105EMS pseudouridine synthase BG04_3022 ENOG4107S1Q Phosphatase BG04_3023 ENOG4105CJW magnesium transporter BG04_3035 ENOG4105ENA helicase BG04_3037 ENOG4105H67 Protein of unknown function (DUF421) BG04_3039 ENOG4108ZMI UPF0477 protein BG04_3044 ENOG4106KNT transcriptional regulator BG04_3046 ENOG4105CMG Carbohydrate kinase BG04_3047 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BG04_3048 ENOG4105C6Z Gluconate BG04_3052 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BG04_3053 ENOG4107ZXU DSBA oxidoreductase BG04_3055 ENOG4105C1J atp-dependent rna helicase BG04_3056 ENOG4106N3A copper homeostasis protein cutc BG04_3057 ENOG4105C85 amino acid BG04_3059 ENOG4108W8B Beta-lactamase domain protein BG04_3061 ENOG4105EMD TRANSCRIPTIONal BG04_3062 ENOG4105VZJ PTS System BG04_3063 ENOG4105CK1 PTS System BG04_3064 ENOG4105VCP PTS System BG04_3065 ENOG4105F8D glycoside hydrolase family 4 BG04_3066 ENOG4108HRK Histidine kinase BG04_3067 ENOG4105DY9 regulatoR BG04_3068 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) BG04_3069 ENOG41067MG lrgb family BG04_3071 ENOG4108IFG nitrite reductase, (NAD(P)H) BG04_3072 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BG04_3074 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BG04_3077 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BG04_3079 ENOG4105DTI Phosphonopyruvate decarboxylase BG04_3080 ENOG4107STF Involved in phosphonate degradation (By similarity) BG04_3082 ENOG4107FQX Alpha-acetolactate decarboxylase BG04_3087 ENOG4105KVH Transcriptional regulator BG04_3088 ENOG4105F27 Major Facilitator BG04_3089 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BG04_3090 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BG04_3093 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) BG04_3098 ENOG4105CSV Glutaminase BG04_31 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BG04_310 ENOG4108W15 Protein of unknown function (DUF1456) BG04_3100 ENOG4105E1V na solute symporter BG04_3102 ENOG4105Q95 Cupin 2, conserved barrel domain protein BG04_3103 ENOG4107QTZ amino acid BG04_3105 ENOG4108S4H thioesterase Superfamily protein BG04_3106 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BG04_3109 ENOG4105C4B ABC transporter, permease BG04_3110 ENOG4108IXI (ABC) transporter BG04_3113 ENOG4107X8C Efflux transporter RND family MFP subunit BG04_3114 ENOG4105C19 ABC transporter BG04_3115 ENOG4107RBB ABC transporter, permease BG04_3117 ENOG4105EEI dihydropteroate synthase BG04_312 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BG04_3121 ENOG4108IQI permease BG04_3123 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BG04_3124 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BG04_3126 ENOG4108ZCF integral membrane protein BG04_3127 ENOG4105CK2 sodium dicarboxylate symporter BG04_3128 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BG04_3129 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BG04_3130 ENOG4108MRH transcriptional regulatory protein BG04_3131 ENOG4105CSC Glucose uptake protein BG04_3132 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BG04_3136 ENOG4107D63 BG04_3137 ENOG4105VZ8 Transcriptional regulator BG04_3139 ENOG4105E0M Sulfatase BG04_3142 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG04_3143 ENOG4108J5H Homocysteine s-methyltransferase BG04_3144 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BG04_3147 ENOG4105D4T Citrate transporter BG04_3149 ENOG4108MRH transcriptional regulatory protein BG04_3151 ENOG4108KAM Transcriptional regulator BG04_3152 ENOG4108KK1 membrane protein AbrB duplication BG04_3153 ENOG41089UC methyltransferase, type 11 BG04_3154 ENOG4107SQ8 Glycine betaine BG04_3155 ENOG4108IJ7 Glycine betaine BG04_3158 ENOG4105C26 Dehydrogenase BG04_3159 ENOG4105C8Y Acetylornithine aminotransferase BG04_3161 ENOG4105CUB amino acid BG04_3162 ENOG4107YBY Hydrolase BG04_3164 ENOG4107T8P acyl-Coa dehydrogenase BG04_3165 ENOG4105FBW Monooxygenase BG04_3166 ENOG4107T8P acyl-Coa dehydrogenase BG04_3167 ENOG4108HUF Transporter BG04_3168 ENOG4105DQ5 transport system permease protein BG04_3170 ENOG4108U1V ABC transporter, permease BG04_3175 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BG04_318 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BG04_3180 ENOG4105ETU transcriptional activator (TenA BG04_3182 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BG04_3185 ENOG41080HJ 6-phospho 3-hexuloisomerase BG04_3186 ENOG4108VA3 3-hexulose-6-phosphate synthase BG04_3187 ENOG4105KVH Transcriptional regulator BG04_3194 ENOG4105ECB domain protein BG04_3196 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BG04_3197 ENOG4105KVH Transcriptional regulator BG04_3198 ENOG4108JA1 polyketide synthase BG04_3199 ENOG4105BZ1 (ABC) transporter BG04_320 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_3200 ENOG4105BZ1 (ABC) transporter BG04_3204 ENOG4105MI2 BG04_3205 ENOG4107HP6 Transcriptional regulator BG04_3207 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BG04_3208 ENOG41067TZ transcriptional regulator, MarR family BG04_3209 ENOG4105CW7 secretion protein, HlyD family BG04_3210 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_3211 ENOG4105CS1 NAD(P)H quinone oxidoreductase BG04_3214 ENOG4105ETE Transcriptional regulator (LacI family BG04_3215 ENOG4108RVA ribokinase BG04_3216 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BG04_3217 ENOG4105C2J ABC transporter BG04_3218 ENOG4105CNN ABC, transporter BG04_3219 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BG04_3220 ENOG41069ER domain protein BG04_3221 ENOG4107XC4 flavin reductase domain protein, FMN-binding BG04_3227 ENOG4105BZU Histidine kinase BG04_3229 ENOG4107QJZ Glycosyl transferase, family 2 BG04_3231 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG04_3232 ENOG4105BZU Histidine kinase BG04_3234 ENOG4106HB6 Alpha beta hydrolase BG04_3236 ENOG4108JPW Aminotransferase BG04_3240 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BG04_3241 ENOG4105C7N Xanthine uracil vitamin C permease BG04_3242 ENOG4105ETE Transcriptional regulator (LacI family BG04_3243 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BG04_3246 ENOG4105FF2 Type I DHQase BG04_3248 ENOG4105C5Y PTS System BG04_3249 ENOG4105CG3 alpha amylase, catalytic region BG04_3250 ENOG4107414 GntR family transcriptional regulator BG04_3251 ENOG4105P4J Allophanate hydrolase, subunit 1 BG04_3253 ENOG4105E7W lamb ycsf family protein BG04_3254 ENOG4105C5A transporter BG04_3255 ENOG4108UT2 hemolysin iii BG04_3258 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase BG04_3259 ENOG4106F5Q Membrane BG04_326 ENOG4105CHH sulfate transporter BG04_3261 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BG04_3263 ENOG4105E2X shikimate dehydrogenase BG04_3265 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BG04_3266 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BG04_3270 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BG04_3273 ENOG4105CUB amino acid BG04_3274 ENOG4105DZC cytosine deaminase BG04_3275 ENOG4105VEQ Cold shock protein BG04_3276 ENOG4108RYK Nad-dependent epimerase dehydratase BG04_3277 ENOG4105EE0 oxidoreductase BG04_3278 ENOG4105D3R alkyl hydroperoxide reductase BG04_3279 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG04_3284 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BG04_3285 ENOG4105KPY Small multidrug resistance protein BG04_3286 ENOG4105KPY Small multidrug resistance protein BG04_3300 ENOG4105F32 YngK protein BG04_3301 ENOG4106KNT transcriptional regulator BG04_3305 ENOG4105F8D glycoside hydrolase family 4 BG04_3307 ENOG4105VCP PTS System BG04_3309 ENOG4105RD7 BadF BadG BcrA BcrD BG04_3310 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BG04_3311 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia BG04_3313 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC BG04_3316 ENOG4105E66 phosphoriboisomerase A BG04_3319 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BG04_3320 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BG04_3321 ENOG4108WAV Transcriptional regulator BG04_3323 ENOG4105CPC Aldo Keto reductase BG04_3326 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BG04_3328 ENOG4105CMR udp-glucose 4-epimerase BG04_333 ENOG4105MXK Carbon dioxide concentrating mechanism protein BG04_3334 ENOG4105BZU Histidine kinase BG04_3335 ENOG4105BZU Histidine kinase BG04_3336 ENOG4105KVH Transcriptional regulator BG04_3337 ENOG4105CSC Glucose uptake protein BG04_3338 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BG04_3339 ENOG4105C09 Bile acid BG04_3340 ENOG4106CAD Protein of unknown function (DUF3311) BG04_3341 ENOG4105E1V na solute symporter BG04_3349 ENOG4105JFG SpoIID LytB domain protein BG04_3350 ENOG4105CV8 reductase BG04_3354 ENOG4105DTQ mandelate racemase muconate lactonizing BG04_3358 ENOG4108JPW Aminotransferase BG04_3361 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_3364 ENOG41082BM Transcriptional regulator, arsr family BG04_3369 ENOG4105BZU Histidine kinase BG04_3370 ENOG4105EUJ GTP cyclohydrolase i BG04_3371 ENOG4108JU3 Alkyl hydroperoxide reductase BG04_3373 ENOG4105BZU Histidine kinase BG04_3392 ENOG4107RVV histidinol phosphate phosphatase, hisj family BG04_3393 ENOG4108IMY Transcriptional regulator BG04_34 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_3402 ENOG4107T8Q Glycosyl transferase (Group 1 BG04_341 ENOG4105KAC Antibiotic biosynthesis monooxygenase BG04_3412 ENOG4105EY8 ABC transporter BG04_3416 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BG04_3417 ENOG4105D3Q Sugar transferase BG04_3418 ENOG4105C30 Nad-dependent epimerase dehydratase BG04_3419 ENOG4105C0K Gdp-mannose 4,6-dehydratase BG04_342 ENOG4105BZU Histidine kinase BG04_3421 ENOG4108UW5 maltose o-acetyltransferase BG04_3423 ENOG4106WTF Glycosyl transferase, family 2 BG04_343 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG04_3430 ENOG4105C6Y Udp-glucose 6-dehydrogenase BG04_3431 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BG04_3433 ENOG4105DG6 mannose-6-phosphate isomerase BG04_3434 ENOG4105HTX biosynthesis protein BG04_3435 ENOG4107YJ4 chain length determinant protein BG04_3436 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BG04_3438 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BG04_3439 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BG04_3442 ENOG4108KGH TRANSCRIPTIONal BG04_3444 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BG04_3447 ENOG4105CBC glutamate synthase BG04_3449 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BG04_3451 ENOG4105C6Z Gluconate BG04_3455 ENOG4108IFG nitrite reductase, (NAD(P)H) BG04_3456 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BG04_3457 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BG04_3458 ENOG4108QTI )-transporter BG04_346 ENOG4105CJ1 ABC, transporter BG04_3460 ENOG4105D7K pfkb domain protein BG04_3464 ENOG4107QJQ Mate efflux family protein BG04_3466 ENOG4105DNP FAD linked oxidase domain protein BG04_3467 ENOG4108KGH TRANSCRIPTIONal BG04_3469 ENOG4105D7N magnesium and cobalt transport protein CorA BG04_3470 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BG04_3474 ENOG4108SU4 UPF0309 protein BG04_3475 ENOG4105FDP GntR family transcriptional regulator BG04_3476 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BG04_3477 ENOG4105CE4 GlcNAc 6-P deacetylase BG04_3478 ENOG4105CI1 PTS System BG04_3479 ENOG4108UQV Membrane BG04_3486 ENOG4105CJ1 ABC, transporter BG04_3487 ENOG4105C37 (CBS) domain BG04_3490 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BG04_3499 ENOG4108XSB acetyltransferase, (GNAT) family BG04_35 ENOG41067TZ transcriptional regulator, MarR family BG04_3500 ENOG4105CH2 amidohydrolase BG04_3506 ENOG4105RHY Pfam:UPF0157 BG04_3507 ENOG4105DP8 Major facilitator superfamily MFS_1 BG04_3509 ENOG4105C7N Xanthine uracil vitamin C permease BG04_3511 ENOG4107Y7X LytTR BG04_3512 ENOG4108IUW ABC transporter BG04_3513 ENOG4108SDH ABC, transporter BG04_3517 ENOG4105E0X reductase BG04_3518 ENOG4108B31 Spore germination protein BG04_3521 ENOG4105G6Z alkaline phosphatase BG04_3522 ENOG4105DY9 regulatoR BG04_3523 ENOG4105BZU Histidine kinase BG04_3524 ENOG4107TS3 membrane protein, TerC BG04_3525 ENOG4108WZW RNA polymerase sigma BG04_3526 ENOG410681C small acid-soluble spore protein BG04_353 ENOG4105VMP Transcriptional regulator BG04_3530 ENOG4105CHR reductase BG04_3536 ENOG4105JXH GntR family transcriptional regulator BG04_3537 ENOG4105DAP Nicotinate phosphoribosyltransferase BG04_3538 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BG04_3539 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BG04_3540 ENOG4107QR9 Iron-sulfur cluster binding protein BG04_3541 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BG04_3542 ENOG4105BZU Histidine kinase BG04_3543 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BG04_3545 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BG04_3546 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BG04_3547 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BG04_3549 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BG04_355 ENOG4105EGI Transcriptional regulator BG04_3550 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BG04_3551 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BG04_3552 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BG04_3554 ENOG4105C2J ABC transporter BG04_3555 ENOG4105CNN ABC, transporter BG04_3560 ENOG41090MY MarR family Transcriptional regulator BG04_3562 ENOG4105BZU Histidine kinase BG04_3565 ENOG4105DFD Na H antiporter BG04_3570 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BG04_3571 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BG04_3572 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BG04_3573 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BG04_3574 ENOG4105K4T epimerase BG04_3580 ENOG4105F0V Cell wall hydrolase BG04_359 ENOG4105DQ4 alcohol dehydrogenase BG04_3590 ENOG4108K88 Membrane BG04_3591 ENOG4108R6K riboflavin synthase, subunit alpha BG04_3593 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BG04_3595 ENOG4105CID antiterminator BG04_3597 ENOG4105KRI phosphocarrier protein (HPr BG04_3598 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BG04_3599 ENOG41067MG lrgb family BG04_36 ENOG4107TXC Transcriptional regulator BG04_360 ENOG4105VUF Transcriptional regulator BG04_3600 ENOG4105VAW lrga family BG04_3601 ENOG4105CMU LysR family (Transcriptional regulator BG04_3604 ENOG4105CHR reductase BG04_3606 ENOG4105CHM Aminotransferase BG04_3610 ENOG4107R88 Chemotaxis protein (CheV) BG04_3611 ENOG4105UIN BG04_3612 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BG04_3613 ENOG4107R33 ppx gppa phosphatase BG04_3614 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BG04_3617 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BG04_3618 ENOG4105EPM Diguanylate phosphodiesterase BG04_3621 ENOG4107IN1 Protein of unknown function (DUF1797) BG04_3624 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BG04_3625 ENOG4105CH2 amidohydrolase BG04_3627 ENOG4105D8X mechanosensitive ion channel BG04_3628 ENOG4105D3R alkyl hydroperoxide reductase BG04_3629 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG04_363 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BG04_3631 ENOG4105BZ1 (ABC) transporter BG04_3632 ENOG4105BZ1 (ABC) transporter BG04_3633 ENOG4107ZYR domain protein BG04_3634 ENOG4105CN5 Metallo-Beta-Lactamase BG04_3635 ENOG4106EHS UPF0356 protein BG04_3636 ENOG4108X4Q Hydrolase BG04_3641 ENOG4105CPP Dehydrogenase, E1 component BG04_3642 ENOG4105C7S Dehydrogenase BG04_3645 ENOG4105C94 Transporter BG04_3647 ENOG4105CXN decarboxylase BG04_3648 ENOG4105WBI UPF0223 protein BG04_3651 ENOG4105ECY inositol monophosphatase BG04_3653 ENOG4105CI3 gtp-binding protein typa BG04_3654 ENOG4105QA2 BG04_3659 ENOG4108IAB Phoh family BG04_3662 ENOG4105CNI cell division protein FtsW BG04_3663 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BG04_3664 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BG04_3665 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BG04_3672 ENOG41080XQ Signal transduction protein with cbs domains BG04_3673 ENOG4106UY4 Inherit from COG: Scp-like extracellular BG04_3676 ENOG4108JYZ YitT family BG04_3677 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BG04_3678 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BG04_3679 ENOG4108Z5K methylglyoxal synthase BG04_368 ENOG4105VEQ Cold shock protein BG04_3680 ENOG4105FJR Lmbe family BG04_3681 ENOG4105CPK Glycosyl transferase (Group 1 BG04_3682 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BG04_3683 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BG04_3685 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BG04_3686 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BG04_3687 ENOG4105DVT helicase BG04_3689 ENOG4105YAC BG04_3691 ENOG4105CHM Aminotransferase BG04_3694 ENOG4105CSM endonuclease III BG04_3696 ENOG4105BZ4 penicillin-binding protein BG04_37 ENOG4108MK9 spermidine N(1)-acetyltransferase BG04_370 ENOG4105C8Q Methyl-accepting chemotaxis BG04_3708 ENOG4106UIA BG04_371 ENOG4108VXD carboxy-peptidase BG04_3710 ENOG4105C28 cystathionine BG04_3711 ENOG4105C28 cystathionine BG04_3714 ENOG4105CK7 Sodium proline symporter BG04_3717 ENOG4105VEQ Cold shock protein BG04_372 ENOG4107QKS N-acylglucosamine 2-epimerase BG04_3720 ENOG4105BZU Histidine kinase BG04_3722 ENOG4108I5C dEAD DEAH box helicase BG04_3723 ENOG4107X2U Inherit from COG: Exonuclease-like protein BG04_3725 ENOG4106F55 Protein of unknown function (DUF1273) BG04_3726 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BG04_3730 ENOG4105ENE Histidine kinase BG04_3731 ENOG4105WH1 Two component transcriptional regulator luxr family BG04_3733 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BG04_3736 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BG04_3740 ENOG4105DVT helicase BG04_3741 ENOG4105CTD carboxy-peptidase BG04_3742 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BG04_3743 ENOG4105C2W permease BG04_3744 ENOG4106NZI LysR family Transcriptional regulator BG04_3745 ENOG4105C26 Dehydrogenase BG04_3747 ENOG41065KQ synthase BG04_3750 ENOG410890F Dynamin family BG04_3751 ENOG410756H nucleotidyltransferase BG04_3756 ENOG41081VK Ribonuclease BG04_376 ENOG4106SCS STAS domain BG04_3765 ENOG4108ME1 Peptidase M55 D-aminopeptidase BG04_3766 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG04_3767 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG04_3768 ENOG4105C3U ABC transporter BG04_3770 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BG04_3771 ENOG4107SN7 NLP P60 protein BG04_3772 ENOG4108JQ7 (ABC) transporter BG04_3775 ENOG4105KNA -acetyltransferase BG04_3776 ENOG4105BZU Histidine kinase BG04_378 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BG04_3782 ENOG4108S01 response regulator BG04_3783 ENOG4108ZGX Histidine kinase BG04_3784 ENOG4105ECK Fatty Acid Desaturase BG04_3786 ENOG4105IIP Membrane BG04_3787 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BG04_3788 ENOG4108TM9 integral membrane protein BG04_3790 ENOG4105K4H Nlp p60 protein BG04_3791 ENOG41087PP glycosyltransferase MGT family BG04_3797 ENOG41069H0 dihydroorotase EC 3.5.2.3 BG04_3801 ENOG4105FDP GntR family transcriptional regulator BG04_3802 ENOG4105C6Z Gluconate BG04_3803 ENOG4106P19 photosystem i assembly btpa BG04_3804 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 BG04_3806 ENOG4105G6Z alkaline phosphatase BG04_3807 ENOG4107ZXU DSBA oxidoreductase BG04_3810 ENOG41067TZ transcriptional regulator, MarR family BG04_3811 ENOG4105CW7 secretion protein, HlyD family BG04_3812 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_3817 ENOG4105EHG Permease protein BG04_3818 ENOG4105DQ5 transport system permease protein BG04_3820 ENOG4105E0A ABC, transporter BG04_3823 ENOG4105C28 cystathionine BG04_3824 ENOG4105C2C drug resistance transporter, Bcr CflA BG04_3828 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BG04_3829 ENOG4105KVH Transcriptional regulator BG04_3830 ENOG4108VA3 3-hexulose-6-phosphate synthase BG04_3832 ENOG4105F76 Sarcosine oxidase BG04_3833 ENOG4105DVW rieske (2Fe-2S) BG04_3834 ENOG4108IJ7 Glycine betaine BG04_3837 ENOG4105BZU Histidine kinase BG04_3838 ENOG4105BZU Histidine kinase BG04_3839 ENOG4108MJI response regulator BG04_384 ENOG4105F1N DNA alkylation repair BG04_3841 ENOG4105CUB amino acid BG04_3844 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BG04_3845 ENOG4105EDQ levansucrase EC 2.4.1.10 BG04_3846 ENOG4108HKT sucrose-6-phosphate hydrolase BG04_3847 ENOG4108UQY Iron-storage protein BG04_3848 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_3850 ENOG4105EXW epimerase dehydratase BG04_3851 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) BG04_3852 ENOG4107RGD Major Facilitator superfamily BG04_3855 ENOG4105C26 Dehydrogenase BG04_3862 ENOG4105CN5 Metallo-Beta-Lactamase BG04_3871 ENOG4105YWU small acid-soluble spore protein BG04_3872 ENOG4105ETE Transcriptional regulator (LacI family BG04_3873 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BG04_3874 ENOG4108HKT sucrose-6-phosphate hydrolase BG04_3875 ENOG4105CNG UPF0061 protein BG04_3876 ENOG4105EDQ levansucrase EC 2.4.1.10 BG04_3877 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BG04_3878 ENOG4105YHU PTS system BG04_3879 ENOG4108IQ3 PTS system BG04_3880 ENOG4105ETZ PTS System BG04_3881 ENOG4105F3R pts system mannose fructose sorbose family iid BG04_3882 ENOG4108HKT sucrose-6-phosphate hydrolase BG04_3883 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BG04_3886 ENOG4108UIN ybak prolyl-trna synthetase associated region BG04_3889 ENOG4105C84 Histidine ammonia-lyase BG04_3891 ENOG4105CI2 imidazolone-5-propionate hydrolase BG04_3892 ENOG4108903 Formimidoylglutamase BG04_3893 ENOG4108SY4 MarR family Transcriptional regulator BG04_3896 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BG04_3898 ENOG4105DYB Isoaspartyl dipeptidase BG04_390 ENOG4105JXH GntR family transcriptional regulator BG04_3901 ENOG4105EKQ RNA-directed DNA polymerase BG04_3906 ENOG4105KNA -acetyltransferase BG04_3912 ENOG4108U05 Transcriptional regulator BG04_3913 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BG04_3914 ENOG41082BM Transcriptional regulator, arsr family BG04_3926 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 BG04_3929 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BG04_3933 ENOG4105K4H Nlp p60 protein BG04_394 ENOG4105XPP Protein of unknown function (DUF1275) BG04_3946 ENOG4107V2S Transcriptional regulator BG04_3947 ENOG4108XEP Alpha Beta Hydrolase Fold protein BG04_3950 ENOG4108PSK reductase BG04_3954 ENOG4107ZTW SNARE associated Golgi BG04_396 ENOG4105E98 transcriptional regulator DeoR family BG04_3962 ENOG4105E1K spore germination protein BG04_3963 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF BG04_397 ENOG410667J hydrolase BG04_3970 ENOG4105C0A alcohol dehydrogenase BG04_3972 ENOG4105ETE Transcriptional regulator (LacI family BG04_3973 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BG04_3974 ENOG4105CY2 Citrate transporter BG04_3975 ENOG4105CHR reductase BG04_3976 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) BG04_3977 ENOG4107RT3 EamA-like transporter family BG04_3978 ENOG4105GZI Transcriptional regulator BG04_3980 ENOG4105EYF MMPL domain protein BG04_3981 ENOG4108XG4 DNA-binding transcriptional regulator BG04_3982 ENOG4107TS3 membrane protein, TerC BG04_399 ENOG4105C5I Dehydrogenase BG04_3990 ENOG4105XDF Protein of unknown function (DUF1272) BG04_3995 ENOG4105KPY Small multidrug resistance protein BG04_4005 ENOG4105C7K acetolactate synthase BG04_4012 ENOG4106GRI small acid-soluble spore protein H BG04_4014 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG04_4015 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BG04_4016 ENOG41080XP Cbs domain BG04_4018 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme BG04_4019 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BG04_4020 ENOG4105CY2 Citrate transporter BG04_4022 ENOG4107R37 Glutamate dehydrogenase BG04_4023 ENOG4105C5Q Transcriptional regulator BG04_4024 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BG04_4025 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG04_4026 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG04_4028 ENOG4108JQ7 (ABC) transporter BG04_4029 ENOG4107R73 Mate efflux family protein BG04_4033 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BG04_4035 ENOG4107U9B transcriptional regulator BG04_4036 ENOG4105DXI Major Facilitator superfamily BG04_4037 ENOG4107HP6 Transcriptional regulator BG04_4041 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG04_4042 ENOG4105C01 Dihydroxy-acid dehydratase BG04_4043 ENOG4105C6Z Gluconate BG04_4044 ENOG4105VRS hydrolase family 18 BG04_4045 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BG04_4052 ENOG4108I0C methyltransferase BG04_4054 ENOG4105KVH Transcriptional regulator BG04_4059 ENOG4108MK9 spermidine N(1)-acetyltransferase BG04_4060 ENOG4108M26 parallel beta-helix repeat protein BG04_4063 ENOG4107R5R arsenical pump membrane protein BG04_4064 ENOG41082YX Transcriptional regulator, arsr family BG04_4066 ENOG41085FC arsR family transcriptional regulator BG04_4069 ENOG4105KAC Antibiotic biosynthesis monooxygenase BG04_4070 ENOG4105MJ9 esterase BG04_4087 ENOG4105ECK Fatty Acid Desaturase BG04_4090 ENOG4105C1J atp-dependent rna helicase BG04_411 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BG04_4118 ENOG4105DQ6 Transposase BG04_4119 ENOG4105MCT stage V sporulation protein S BG04_4122 ENOG4108FPN Integrase BG04_4123 ENOG4108HE4 integrase family BG04_4125 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BG04_4129 ENOG4105ES4 Nitrilase BG04_4131 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BG04_4132 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BG04_4133 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG04_4134 ENOG4105CIH Imidazole acetol-phosphate transaminase BG04_4136 ENOG4107JTW chlorite dismutase BG04_4137 ENOG4105CXN decarboxylase BG04_414 ENOG4107QNK )-transporter BG04_4143 ENOG4107RSM transcriptional regulator BG04_4148 ENOG4107BMA Transglycosylase associated protein BG04_415 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BG04_4151 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BG04_4161 ENOG4108T9Y Inner membrane protein ydcZ BG04_4167 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BG04_4169 ENOG4105CPC Aldo Keto reductase BG04_4171 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BG04_4173 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BG04_4174 ENOG4108Z66 YbaK ebsC protein BG04_4176 ENOG4105CSH Transporter BG04_418 ENOG4105CMD Transcriptional regulator, GntR family BG04_4180 ENOG4105C26 Dehydrogenase BG04_4186 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BG04_4188 ENOG41080XP Cbs domain BG04_419 ENOG4107TVP HD domain protein BG04_4191 ENOG4108IG5 Transcriptional regulator BG04_4194 ENOG4105CMG Carbohydrate kinase BG04_4195 ENOG4107QNK )-transporter BG04_4196 ENOG4108JUB Transcriptional regulator BG04_4197 ENOG4105D4T Citrate transporter BG04_4201 ENOG4105E2S oxidase) subunit II BG04_4202 ENOG4105BZ9 Cytochrome C oxidase, subunit I BG04_4203 ENOG4105CCU oxidase (Subunit III) BG04_4205 ENOG4107YZX Universal stress protein BG04_4206 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BG04_4207 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BG04_4208 ENOG4105E1J oxidoreductase BG04_421 ENOG4105CE1 Ferrous iron transport protein b BG04_4210 ENOG4105C7N Xanthine uracil vitamin C permease BG04_4211 ENOG4108J9M Transporter BG04_4212 ENOG4107RUY (E1 component), alpha subunit BG04_4214 ENOG4107QKR Dehydrogenase BG04_4216 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BG04_4218 ENOG4105C28 cystathionine BG04_422 ENOG4105CE1 Ferrous iron transport protein b BG04_4223 ENOG4105C02 permease BG04_4224 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BG04_4227 ENOG4105CT4 transporter BG04_423 ENOG4105CE1 Ferrous iron transport protein b BG04_4231 ENOG4107YZX Universal stress protein BG04_4233 ENOG4105BZU Histidine kinase BG04_4235 ENOG4105VPX protein, conserved in bacteria BG04_4236 ENOG410681U heavy metal transport detoxification protein BG04_4237 ENOG4105C59 p-type ATPase BG04_4239 ENOG41090UD (LipO)protein BG04_4248 ENOG41082YX Transcriptional regulator, arsr family BG04_4249 ENOG4107R5R arsenical pump membrane protein BG04_4251 ENOG4108VUY thioesterase Superfamily protein BG04_4252 ENOG41081VB Hydrolase BG04_4253 ENOG4108QY0 Membrane BG04_4256 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BG04_4257 ENOG4105DRR Transcriptional regulator, GntR family BG04_4258 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BG04_4259 ENOG4105CZM Major Facilitator BG04_4260 ENOG4105KVH Transcriptional regulator BG04_4261 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BG04_4267 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BG04_4269 ENOG4105X5K response regulator receiver protein BG04_4271 ENOG4105KHC sulfurtransferase BG04_4275 ENOG4108ZJ4 polysaccharide deacetylase BG04_4282 ENOG4105CVG Homoserine O-transsuccinylase BG04_4285 ENOG4108V06 Glutathione peroxidase BG04_4287 ENOG4105C5H ABC transporter BG04_4289 ENOG4108ZJ4 polysaccharide deacetylase BG04_4290 ENOG4108Y6J UPF0403 protein BG04_4291 ENOG4107YX5 Pfam:DUF548 BG04_4293 ENOG4105SZ6 Thioredoxin BG04_4294 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BG04_4296 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) BG04_4299 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BG04_4300 ENOG4105CVJ phosphoglycerate mutase BG04_4302 ENOG4108WBT adenosyltransferase BG04_4303 ENOG4105FR1 rard protein BG04_4306 ENOG4105CKI cobalamin synthesis protein BG04_4307 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BG04_4308 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BG04_4313 ENOG4105II7 pyrroline-5-carboxylate reductase BG04_4314 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BG04_4315 ENOG4108AEY RNA polymerase sigma factor BG04_4320 ENOG4107QMU Mate efflux family protein BG04_4321 ENOG4105CHR reductase BG04_4328 ENOG4105CDW Resistance protein BG04_4332 ENOG4108ZJ4 polysaccharide deacetylase BG04_4334 ENOG4105IIU Aminopeptidase BG04_4335 ENOG4105BZU Histidine kinase BG04_4337 ENOG4107R6U sodium dicarboxylate symporter BG04_4338 ENOG4108IUM Glycogen debranching enzyme BG04_4339 ENOG4105C26 Dehydrogenase BG04_4340 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BG04_4344 ENOG4105E14 MotA TolQ exbB proton channel BG04_4345 ENOG4105ER2 Ompa motb domain protein BG04_4348 ENOG4108NA0 Uncharacterized conserved protein (COG2071) BG04_4350 ENOG4105DFD Na H antiporter BG04_4353 ENOG4108TGC Acyltransferase BG04_4354 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BG04_4356 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG04_4357 ENOG4105US7 Histidine kinase BG04_4358 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) BG04_4359 ENOG4105DUX Transporter BG04_4361 ENOG4105C6K Malic enzyme BG04_4363 ENOG410667J hydrolase BG04_4364 ENOG4105DEN Luciferase family BG04_4366 ENOG4108XSB acetyltransferase, (GNAT) family BG04_4371 ENOG4105CDA abc transporter atp-binding protein BG04_4375 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BG04_438 ENOG4108RPX mosc domain containing protein BG04_4383 ENOG4108URH decarboxylase BG04_4385 ENOG410905X membrane-flanked domain protein BG04_4386 ENOG4105CKV Membrane BG04_4389 ENOG4105D7K pfkb domain protein BG04_439 ENOG4105D9N nucleoside BG04_4390 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BG04_4391 ENOG4105K7W phage-related replication protein BG04_4394 ENOG4107SWG transcriptional regulator MERR family BG04_4399 ENOG41069DP small acid-soluble spore protein BG04_4400 ENOG4108R1P BG04_4401 ENOG4105C5Q Transcriptional regulator BG04_4402 ENOG4105CBC glutamate synthase BG04_4403 ENOG4105BZ8 glutamate synthase BG04_4407 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BG04_4410 ENOG4107RZC phospholipase d BG04_4412 ENOG41061AU MarR family Transcriptional regulator BG04_4414 ENOG41067MG lrgb family BG04_4418 ENOG4105EDW glycosyl transferase, family 39 BG04_4419 ENOG4105CKK Glycosyl transferase, family 2 BG04_4421 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BG04_4422 ENOG4105EFI regulatoR BG04_4426 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BG04_4427 ENOG4108I5D sulfate abc transporter BG04_4428 ENOG4105ECW sulfate abc transporter BG04_4431 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG04_4436 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BG04_4439 ENOG4105E98 transcriptional regulator DeoR family BG04_4440 ENOG4105DE4 1-phosphofructokinase BG04_4441 ENOG4105DM4 PTS System BG04_4442 ENOG4105CFH Aspartokinase BG04_4444 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BG04_4447 ENOG4108W6C Dehydrogenase BG04_4448 ENOG41082YX Transcriptional regulator, arsr family BG04_4449 ENOG4105C26 Dehydrogenase BG04_4450 ENOG4105ETU transcriptional activator (TenA BG04_4454 ENOG4105C8J )-transporter BG04_4455 ENOG4105F0V Cell wall hydrolase BG04_4459 ENOG4105CK5 oxidoreductase BG04_4460 ENOG4107QP6 Xylose isomerase domain protein TIM barrel BG04_4461 ENOG4108VX5 3-methyladenine DNA glycosylase BG04_4462 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BG04_4464 ENOG4105I4A GCN5-related N-acetyltransferase BG04_4465 ENOG41062JF Transcriptional regulator BG04_4469 ENOG410606W general stress protein BG04_447 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BG04_4476 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BG04_4477 ENOG4107T89 von Willebrand factor, type A BG04_4478 ENOG4108UZ3 Transporter BG04_4480 ENOG41075H3 AraC family transcriptional regulator BG04_4482 ENOG4108428 Inherit from COG: -acetyltransferase BG04_4483 ENOG4105DKW ABC transporter BG04_4486 ENOG4105EWU Squalene--hopene cyclase BG04_4488 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BG04_449 ENOG41069DP small acid-soluble spore protein BG04_4490 ENOG4105JAB phenazine biosynthesis protein, phzf family BG04_4493 ENOG4108NGU Transcriptional regulator BG04_4494 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BG04_4495 ENOG4105CHR reductase BG04_4498 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG04_4500 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BG04_4504 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_4505 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_4507 ENOG410756H nucleotidyltransferase BG04_4510 ENOG4108IMY Transcriptional regulator BG04_4513 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BG04_4515 ENOG4105DAP Nicotinate phosphoribosyltransferase BG04_4516 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BG04_4517 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BG04_4518 ENOG41060GV RNA binding s1 domain protein BG04_4520 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BG04_4521 ENOG4105DTD Dehydrogenase BG04_4522 ENOG410855V Acylphosphatase BG04_4523 ENOG4105EU0 Major facilitator Superfamily BG04_4524 ENOG4105DEN Luciferase family BG04_4525 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BG04_454 ENOG4105XEA Tetr family transcriptional regulator BG04_455 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BG04_4553 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BG04_456 ENOG4105C85 amino acid BG04_457 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BG04_458 ENOG4106IPI cyclase, family BG04_4582 ENOG4105FTV AraC Family Transcriptional Regulator BG04_4583 ENOG4108RNG Permease of the drug metabolite transporter BG04_4584 ENOG4105C5H ABC transporter BG04_4586 ENOG4108Q8B Spore germination protein BG04_4587 ENOG4108NHD germination protein BG04_4588 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BG04_4589 ENOG4105CJ1 ABC, transporter BG04_459 ENOG41069HH 4-oxalocrotonate tautomerase BG04_4591 ENOG4107S6Z Na H antiporter BG04_4595 ENOG4105F6S Spore photoproduct lyase BG04_4599 ENOG4105C9U ATP-dependent DNA helicase RecQ BG04_4601 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BG04_4604 ENOG4105E2A Dehydrogenase BG04_4605 ENOG4107RZC phospholipase d BG04_4609 ENOG4107S6Z Na H antiporter BG04_4612 ENOG41073R8 VanW family BG04_4625 ENOG4105K64 Glycosyl transferase, family 2 BG04_4628 ENOG4105C9U ATP-dependent DNA helicase RecQ BG04_4631 ENOG4105C26 Dehydrogenase BG04_4634 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BG04_4637 ENOG4105KWG Pfam:DUF1696 BG04_4638 ENOG4105D94 Major Facilitator Superfamily BG04_4639 ENOG4105DUM transcriptional regulator, lysR family BG04_4640 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BG04_4641 ENOG4105DVE abc transporter atp-binding protein BG04_4643 ENOG4105EMN RNA polymerase sigma factor BG04_4646 ENOG4108ZHJ Organic hydroperoxide resistance protein BG04_4647 ENOG4105K56 Transcriptional regulator BG04_465 ENOG4105KME endoribonuclease L-psp BG04_4653 ENOG41069ER domain protein BG04_4656 ENOG4105BZU Histidine kinase BG04_4658 ENOG4105II7 pyrroline-5-carboxylate reductase BG04_4659 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BG04_4660 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BG04_4663 ENOG4105JSC dimethylmenaquinone methyltransferase BG04_4666 ENOG4107R13 MMPL domain protein BG04_4667 ENOG4107TUM Amidinotransferase BG04_4669 ENOG4107U9T Pfam:Ribonuclease_BN BG04_468 ENOG4107V0Z fmn reductase BG04_4680 ENOG4108UW5 maltose o-acetyltransferase BG04_4683 ENOG4106SCS STAS domain BG04_4684 ENOG4106CAD Protein of unknown function (DUF3311) BG04_4685 ENOG4105E1V na solute symporter BG04_4687 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BG04_469 ENOG4105U1N riboflavin BG04_4690 ENOG4105C9Q fumarate hydratase class II BG04_4692 ENOG4107YXZ hydrolase, family 25 BG04_4694 ENOG4105BZU Histidine kinase BG04_4696 ENOG4105D4Y metalloprotease BG04_47 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BG04_470 ENOG4105EFA 4-hydroxyphenylacetate BG04_4701 ENOG4108RCM Nitroreductase BG04_4703 ENOG4108IXY short-chain dehydrogenase reductase BG04_4704 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BG04_4705 ENOG4108V9W transcriptional regulatory protein BG04_4706 ENOG4105D4T Citrate transporter BG04_4708 ENOG4105CY2 Citrate transporter BG04_4709 ENOG4105DTD Dehydrogenase BG04_4710 ENOG4105CIN aminoacyl-histidine dipeptidase BG04_4716 ENOG4105DND Transcriptional regulator BG04_4719 ENOG4105CK2 sodium dicarboxylate symporter BG04_4720 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BG04_4722 ENOG4107VFR oxidoreductase BG04_4724 ENOG4105BZU Histidine kinase BG04_4727 ENOG4105CHR reductase BG04_4728 ENOG4105CEY Amp-dependent synthetase and ligase BG04_4730 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BG04_4731 ENOG4105E39 Enoyl-CoA hydratase BG04_4734 ENOG4108N5B 2-phosphosulfolactate phosphatase BG04_4735 ENOG4105C1G acyl-Coa dehydrogenase BG04_4736 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BG04_4737 ENOG4105CGU Enoyl-CoA hydratase BG04_4738 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BG04_4739 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BG04_4742 ENOG4105D6N CoA-transferase, subunit a BG04_4743 ENOG4107QNJ CoA-transferase subunit B BG04_4744 ENOG4105CHU acetyl-coa acetyltransferase BG04_4745 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BG04_4746 ENOG4108JPW Aminotransferase BG04_4750 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BG04_4752 ENOG4108IQI permease BG04_4753 ENOG4105C5X domain protein BG04_4754 ENOG4106XGU BG04_4759 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BG04_476 ENOG4105CT4 transporter BG04_4760 ENOG4105CPF Cell wall formation (By similarity) BG04_4762 ENOG4108594 Permease of the drug metabolite transporter BG04_4764 ENOG4105JKW Valine--pyruvate aminotransferase BG04_4766 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BG04_4767 ENOG4105F0V Cell wall hydrolase BG04_4768 ENOG4105CBG Sulfatase BG04_4769 ENOG4105C22 threonyL-tRNA synthetase BG04_477 ENOG4105CPQ Dehydrogenase BG04_4771 ENOG4105CUB amino acid BG04_4772 ENOG4105F27 Major Facilitator BG04_4773 ENOG41062A4 Transcriptional regulator BG04_4774 ENOG4105EYF MMPL domain protein BG04_4777 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine BG04_4778 ENOG4105XN3 extracellular solute-binding protein family 1 BG04_4779 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BG04_478 ENOG4105PGZ NB-ARC domain BG04_4780 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BG04_4781 ENOG4108KPW sugar kinase BG04_4782 ENOG4105FDP GntR family transcriptional regulator BG04_4783 ENOG4105BZU Histidine kinase BG04_4785 ENOG41082BM Transcriptional regulator, arsr family BG04_4787 ENOG4107YUH hydrolase BG04_4789 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BG04_4792 ENOG4105NX3 Membrane BG04_4794 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BG04_4795 ENOG4108JQ1 Dehydrogenase BG04_4799 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BG04_4800 ENOG4107YXZ hydrolase, family 25 BG04_4802 ENOG4107Y9U Membrane BG04_4807 ENOG4105WS7 Cation transport regulator BG04_4808 ENOG4105EUZ Beta-lactamase domain protein BG04_4810 ENOG4105D82 Glutamate dehydrogenase BG04_4813 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BG04_4814 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BG04_4828 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BG04_4831 ENOG4105P8F nudix hydrolase BG04_4834 ENOG41067TZ transcriptional regulator, MarR family BG04_4836 ENOG41073R8 VanW family BG04_4837 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BG04_484 ENOG4108ZMX Domain of unknown function (DU1801) BG04_4844 ENOG4105CVK Glutamate decarboxylase BG04_4850 ENOG4105TMB Formate nitrite transporter BG04_4851 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BG04_4855 ENOG4105IQ5 FAD linked oxidase domain protein BG04_4857 ENOG4105C8Q Methyl-accepting chemotaxis BG04_4859 ENOG4108RE9 Phosphodiesterase BG04_4861 ENOG4105DIN metallophosphoesterase BG04_4862 ENOG4108VCA G U mismatch-specific DNA glycosylase BG04_4864 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BG04_4865 ENOG4107258 Transcriptional regulator BG04_4866 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BG04_4869 ENOG4105P4J Allophanate hydrolase, subunit 1 BG04_4870 ENOG4105CFM UPF0317 protein BG04_4871 ENOG4105C5A transporter BG04_4872 ENOG4105E7W lamb ycsf family protein BG04_4873 ENOG4105CG3 alpha amylase, catalytic region BG04_4874 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BG04_4878 ENOG4105F27 Major Facilitator BG04_4879 ENOG4105DUM transcriptional regulator, lysR family BG04_4880 ENOG4105CV8 reductase BG04_4881 ENOG4105CHR reductase BG04_4882 ENOG4108Z0Z intracellular protease Pfpi family BG04_4883 ENOG4105C28 cystathionine BG04_4884 ENOG4105ECR NmrA family BG04_4885 ENOG4105KVH Transcriptional regulator BG04_4886 ENOG4105DQ6 Transposase BG04_4888 ENOG4108JYZ YitT family BG04_4891 ENOG4105WAB arsR family transcriptional regulator BG04_4893 ENOG4105DEN Luciferase family BG04_4894 ENOG4105DEN Luciferase family BG04_4896 ENOG4108VA3 3-hexulose-6-phosphate synthase BG04_4901 ENOG4105DBI uridine monophosphokinase BG04_4905 ENOG4108J8C transporter major facilitator family protein BG04_4907 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BG04_4912 ENOG4105DCM major facilitator superfamily BG04_4913 ENOG410645S MarR family Transcriptional regulator BG04_4916 ENOG4108IPJ Membrane BG04_4920 ENOG4105C1J atp-dependent rna helicase BG04_4928 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase BG04_4930 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid BG04_4942 ENOG4107F3J Amp-dependent synthetase and ligase BG04_4943 ENOG4107ZYJ bioY protein BG04_4945 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BG04_4949 ENOG4105WH1 Two component transcriptional regulator luxr family BG04_495 ENOG4105BZU Histidine kinase BG04_4950 ENOG4105BZU Histidine kinase BG04_4956 ENOG41082BV acetyltransferase BG04_4957 ENOG4105C01 Dihydroxy-acid dehydratase BG04_4958 ENOG4105E5G Alpha beta hydrolase fold BG04_4959 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BG04_4964 ENOG4105CM2 brancheD-chain amino acid aminotransferase BG04_4966 ENOG4105F6E Acyl-transferase BG04_4969 ENOG4105VT2 5-hydroxyisourate hydrolase BG04_4970 ENOG4108MK9 spermidine N(1)-acetyltransferase BG04_4973 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BG04_4975 ENOG4105U0R haloacid dehalogenase-like hydrolase BG04_4976 ENOG41067TZ transcriptional regulator, MarR family BG04_4978 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BG04_498 ENOG4106QJ6 Integrase catalytic subunit BG04_4983 ENOG4107R55 ethanolamine transporter BG04_4984 ENOG4107FQ9 ethanolamine ammonia-lyase BG04_4985 ENOG4105CPD ethanolamine ammonia-lyase BG04_4986 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase BG04_4988 ENOG4108IQI permease BG04_4990 ENOG4108Z7F N-acetyltransferase BG04_4994 ENOG4107S9D Alpha beta hydrolase BG04_4997 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BG04_4998 ENOG4105K4P CoA-binding domain protein BG04_4999 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BG04_5000 ENOG4105W8X HesB YadR YfhF-family protein BG04_5003 ENOG41067CD Small, acid-soluble spore protein Tlp BG04_5005 ENOG41075ZD Small, acid-soluble spore protein N BG04_5007 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BG04_5008 ENOG4108I0Z Aconitate hydratase BG04_5009 ENOG410746C Acid-soluble spore protein O BG04_5010 ENOG4107DZX Small, acid-soluble spore protein P BG04_5012 ENOG4105FDF Could be involved in DNA repair (By similarity) BG04_5013 ENOG4105DQ6 Transposase BG04_5022 ENOG4105C7W Xanthine dehydrogenase BG04_5024 ENOG4105XRQ Xanthine dehydrogenase accessory factor BG04_5036 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BG04_5039 ENOG4105F27 Major Facilitator BG04_5040 ENOG4105EWC Purine nucleoside phosphorylase BG04_5041 ENOG4105VBF alkaline shock protein BG04_5044 ENOG4107U9T Pfam:Ribonuclease_BN BG04_5046 ENOG4105BZG amino acid carrier protein BG04_5047 ENOG4105BZG amino acid carrier protein BG04_5048 ENOG4105C6X Major Facilitator BG04_5050 ENOG4105DXB Major Facilitator superfamily BG04_5051 ENOG4107SWG transcriptional regulator MERR family BG04_5053 ENOG4108V2W Carbonate dehydratase BG04_5054 ENOG4105CHH sulfate transporter BG04_5055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG04_5056 ENOG4105BZU Histidine kinase BG04_5059 ENOG4107QTZ amino acid BG04_5061 ENOG4108ZRV stage ii sporulation protein p BG04_5062 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase BG04_5065 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BG04_5066 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BG04_5067 ENOG4108P62 biosynthesis protein (CbiG) BG04_5068 ENOG4105CIA precorrin-4 C(11)-methyltransferase BG04_5070 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase BG04_5071 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) BG04_5072 ENOG41081F0 Precorrin-8x methylmutase BG04_5073 ENOG4108JTQ reductase BG04_5074 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BG04_5075 ENOG4105E4R Precorrin-3B C17-methyltransferase BG04_5078 ENOG4105DER m42 family BG04_5088 ENOG4107TT2 Auxin Efflux Carrier BG04_5089 ENOG4105C6K Malic enzyme BG04_5090 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B BG04_5092 ENOG41069ZX BG04_5093 ENOG41069ZX BG04_5094 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BG04_5095 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BG04_5096 ENOG4106P55 Transcriptional regulator BG04_5097 ENOG4107TT2 Auxin Efflux Carrier BG04_5101 ENOG4105DEN Luciferase family BG04_5102 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BG04_5103 ENOG4105CQB FAD linked oxidase domain protein BG04_5105 ENOG4107R7Y intracellular protease Pfpi family BG04_5107 ENOG4105CY2 Citrate transporter BG04_5108 ENOG4105C0A alcohol dehydrogenase BG04_5111 ENOG4105CJ1 ABC, transporter BG04_5113 ENOG4105WH1 Two component transcriptional regulator luxr family BG04_5114 ENOG4105CE7 Amidase, hydantoinase carbamoylase family BG04_5121 ENOG4105DEN Luciferase family BG04_5123 ENOG4107T5V SNARE associated Golgi BG04_5124 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BG04_5125 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BG04_5126 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BG04_5129 ENOG4105CUB amino acid BG04_513 ENOG4105CNI cell division protein FtsW BG04_5152 ENOG4105UQX Mate efflux family protein BG04_5153 ENOG4105CW7 secretion protein, HlyD family BG04_5155 ENOG4105FS7 Transcriptional regulator BG04_5156 ENOG4105CGK Exodeoxyribonuclease III BG04_5159 ENOG41090KN UPF0303 protein BG04_516 ENOG4105D7N magnesium and cobalt transport protein CorA BG04_5160 ENOG4105D9R oxidoreductase BG04_5161 ENOG4105E98 transcriptional regulator DeoR family BG04_5163 ENOG4108TTB tellurium resistance protein BG04_5164 ENOG4106FN3 tellurium resistance protein BG04_5165 ENOG4106FN3 tellurium resistance protein BG04_5166 ENOG4108N0M stress protein BG04_5167 ENOG4105CGH 5'-nucleotidase BG04_517 ENOG4105CZN Potassium uptake protein BG04_5170 ENOG4108TU7 Inherit from COG: (ABC) transporter BG04_5171 ENOG4105CJ1 ABC, transporter BG04_5173 ENOG4106KE4 Dehydrogenase BG04_5175 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG04_518 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BG04_5186 ENOG4105CYC Transferase BG04_5187 ENOG4105DY9 regulatoR BG04_5188 ENOG4105H67 Protein of unknown function (DUF421) BG04_5189 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_5190 ENOG41069ER domain protein BG04_5191 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BG04_5196 ENOG4105EC3 peptidase S51, dipeptidase E BG04_5199 ENOG4105DNP FAD linked oxidase domain protein BG04_52 ENOG4105VCH membrane BG04_5204 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) BG04_5205 ENOG4106ANW SMI1_KNR4 BG04_521 ENOG4108Z7G MaoC domain protein dehydratase BG04_5216 ENOG4105F8D glycoside hydrolase family 4 BG04_5217 ENOG4105CK1 PTS System BG04_5218 ENOG4105VZJ PTS System BG04_522 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) BG04_5223 ENOG4105DWT malate dehydrogenase (quinone) BG04_524 ENOG4105E2X shikimate dehydrogenase BG04_5241 ENOG4105I1K ABC transporter BG04_5242 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BG04_5245 ENOG4108UB7 BG04_5249 ENOG4105BZW Glycerate kinase BG04_525 ENOG4105DND Transcriptional regulator BG04_5250 ENOG4107QQ0 gntp family BG04_5251 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BG04_5255 ENOG4105C0A alcohol dehydrogenase BG04_5256 ENOG4105KAF membrAne BG04_5273 ENOG4105ETS cytosine purines uracil thiamine allantoin BG04_5276 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BG04_5282 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) BG04_5283 ENOG4107X8Z Acyl-protein synthetase, LuxE BG04_5285 ENOG4105H3G oxidoreductase BG04_5286 ENOG4107RCI amp-dependent synthetase and ligase BG04_529 ENOG4108RWP Major Facilitator Superfamily protein BG04_5293 ENOG4107QTZ amino acid BG04_5296 ENOG4105K70 DNA-binding protein BG04_5299 ENOG4108Q8B Spore germination protein BG04_5301 ENOG41062D9 Histidine kinase BG04_5302 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BG04_5308 ENOG4105C3M thioredoxin reductase BG04_531 ENOG4105GZI Transcriptional regulator BG04_5312 ENOG4105KAF membrAne BG04_5313 ENOG4105KAF membrAne BG04_5316 ENOG4105IW1 AmiS UreI transporter BG04_5317 ENOG4105D9N nucleoside BG04_5319 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BG04_5322 ENOG4107RHR regulatoR BG04_5328 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BG04_533 ENOG4105DJ2 Major Facilitator Superfamily BG04_5331 ENOG4105D0M Protease HtpX homolog BG04_5332 ENOG41069FQ Metallo-beta-lactamase superfamily BG04_5333 ENOG4105KK4 UPF0060 membrane protein BG04_5334 ENOG4107FKK extracellular solute-binding protein family 1 BG04_5338 ENOG4105CRW Short chain fatty acid transporter BG04_534 ENOG4105GZI Transcriptional regulator BG04_5343 ENOG4105CUC YeeE YedE family protein BG04_5346 ENOG4107QW4 alcohol dehydrogenase BG04_5347 ENOG4107V2S Transcriptional regulator BG04_5357 ENOG4105CHR reductase BG04_5358 ENOG4105CPQ Dehydrogenase BG04_5365 ENOG4107SUZ Sodium/hydrogen exchanger family BG04_5367 ENOG4105C37 (CBS) domain BG04_5370 ENOG4108JQ7 (ABC) transporter BG04_5371 ENOG4105C3U ABC transporter BG04_5372 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BG04_5373 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BG04_5374 ENOG4107RRN ABC transporter substrate-binding protein BG04_5376 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BG04_5380 ENOG4107Y9E nuclease BG04_5382 ENOG4105DWT malate dehydrogenase (quinone) BG04_5383 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BG04_5384 ENOG4105J7I hydrolase BG04_5387 ENOG4105D8X mechanosensitive ion channel BG04_5396 ENOG4107HP6 Transcriptional regulator BG04_5397 ENOG4105ERH Fumarylacetoacetate hydrolase BG04_5398 ENOG4105C82 Malate synthase BG04_5399 ENOG4105CQB FAD linked oxidase domain protein BG04_54 ENOG4105CI2 imidazolone-5-propionate hydrolase BG04_540 ENOG4105DTD Dehydrogenase BG04_5400 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BG04_5401 ENOG4105CQB FAD linked oxidase domain protein BG04_5402 ENOG4105DAA L-lactate BG04_5408 ENOG4105DA5 (ABC) transporter BG04_5409 ENOG41069JR BG04_5416 ENOG4107I77 yiaA/B two helix domain BG04_5419 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BG04_542 ENOG4105IE8 Alpha-ketoglutarate permease BG04_5421 ENOG4105D7N magnesium and cobalt transport protein CorA BG04_5422 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BG04_5424 ENOG4105H67 Protein of unknown function (DUF421) BG04_5425 ENOG4108VXD carboxy-peptidase BG04_5427 ENOG4105BZU Histidine kinase BG04_5428 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BG04_543 ENOG4107QP6 Xylose isomerase domain protein TIM barrel BG04_5432 ENOG4105C7S Dehydrogenase BG04_5433 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BG04_5436 ENOG4108X3M OsmC Ohr family protein BG04_5438 ENOG4105DHF Membrane BG04_544 ENOG4105CIB oxidoreductase Domain protein BG04_5445 ENOG4108IV0 ABC, transporter BG04_5447 ENOG4105BZU Histidine kinase BG04_5448 ENOG4105CFC Transporter BG04_5451 ENOG4105D74 hydrolase BG04_5454 ENOG4105RHY Pfam:UPF0157 BG04_5455 ENOG4105FDT acyl-CoA dehydrogenase BG04_5463 ENOG4108IPW abc transporter atp-binding protein BG04_5464 ENOG4105EHG Permease protein BG04_5465 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BG04_5467 ENOG4107QTZ amino acid BG04_5469 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BG04_547 ENOG4105ETE Transcriptional regulator (LacI family BG04_5471 ENOG41080HJ 6-phospho 3-hexuloisomerase BG04_5475 ENOG4105DJB Major Facilitator Superfamily BG04_5476 ENOG4105D7K pfkb domain protein BG04_548 ENOG4108NEV two component transcriptional regulator, LytTR family BG04_5481 ENOG4105EWK phytoene BG04_5482 ENOG41076QQ Glycosyl transferase, family 2 BG04_549 ENOG4105BZU Histidine kinase BG04_5492 ENOG4105CQM Urea amidohydrolase subunit alpha BG04_5494 ENOG4108YZ9 Urea amidohydrolase subunit gamma BG04_5495 ENOG4108I0Q anthranilate phosphoribosyltransferase BG04_5497 ENOG41069ER domain protein BG04_5498 ENOG4108DBC nitroreductase BG04_5500 ENOG4107ZTW SNARE associated Golgi BG04_5502 ENOG4105FBA Phospholipase Carboxylesterase BG04_5503 ENOG4105BZ4 penicillin-binding protein BG04_5505 ENOG4105T38 integral membrane protein BG04_551 ENOG4105PGS Spore coat protein BG04_5510 ENOG4105BZ1 (ABC) transporter BG04_5515 ENOG4105K7W phage-related replication protein BG04_5518 ENOG4108RMU ferritin dps family protein BG04_552 ENOG4105E2A Dehydrogenase BG04_5521 ENOG4105C37 (CBS) domain BG04_5524 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BG04_5529 ENOG4105EVN Prephenate dehydrogenase BG04_5531 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BG04_5533 ENOG4105FGV Chromate BG04_5534 ENOG4105CAH Chromate BG04_5535 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BG04_5536 ENOG4105C5R Aminotransferase BG04_5538 ENOG4105G9B Transcriptional regulator BG04_5541 ENOG4105CH6 catalase BG04_5544 ENOG4105C8J )-transporter BG04_5553 ENOG410635A Membrane BG04_5554 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BG04_5555 ENOG4105C3F Signal peptidase i BG04_5558 ENOG4105YVS arsR family transcriptional regulator BG04_5560 ENOG4108DBC nitroreductase BG04_5563 ENOG4105RHY Pfam:UPF0157 BG04_5564 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BG04_5565 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BG04_5568 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BG04_5571 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BG04_5572 ENOG4108JYZ YitT family BG04_5576 ENOG4107AYK membrAne BG04_5577 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BG04_5579 ENOG4105BZN citrate synthase BG04_5580 ENOG4105CMU LysR family (Transcriptional regulator BG04_5581 ENOG4105FDR Membrane BG04_5585 ENOG4105BZU Histidine kinase BG04_5588 ENOG4108VA3 3-hexulose-6-phosphate synthase BG04_5589 ENOG4105KVH Transcriptional regulator BG04_5590 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BG04_5592 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BG04_5597 ENOG4108QY0 Membrane BG04_56 ENOG4108KGH TRANSCRIPTIONal BG04_560 ENOG41080XP Cbs domain BG04_5600 ENOG4105CZ3 stage V sporulation protein ad BG04_5601 ENOG41090VF Stage v sporulation protein ac BG04_5609 ENOG4105DQ6 Transposase BG04_561 ENOG4107KM7 Heat induced stress protein YflT BG04_5613 ENOG4105MYT Heat shock protein BG04_5615 ENOG41090MY MarR family Transcriptional regulator BG04_5616 ENOG4105EUB pirin domain protein BG04_5628 ENOG4105MCT stage V sporulation protein S BG04_5636 ENOG4105DQ6 Transposase BG04_5646 ENOG41087PP glycosyltransferase MGT family BG04_5649 ENOG4108WC5 Alpha Beta Hydrolase Fold protein BG04_5653 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BG04_5654 ENOG4108XET gCN5-related N-acetyltransferase BG04_5655 ENOG4105DQ6 Transposase BG04_5670 ENOG4105EKQ RNA-directed DNA polymerase BG04_5675 ENOG4108YV3 Protein of unknown function (DUF2711) BG04_5677 ENOG4105N14 lysine exporter protein LysE YggA BG04_5680 ENOG4108JJA ABC, transporter BG04_5686 ENOG4105VZ8 Transcriptional regulator BG04_5689 ENOG4108IUW ABC transporter BG04_569 ENOG4107U9T Pfam:Ribonuclease_BN BG04_5694 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BG04_5698 ENOG4105F6E Acyl-transferase BG04_57 ENOG41068WN BG04_570 ENOG4105EGS Mechanosensitive ion channel BG04_5702 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BG04_5703 ENOG4105C4R Atp-dependent dna helicase BG04_5707 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BG04_5711 ENOG4105YWU small acid-soluble spore protein BG04_5723 ENOG4105BZU Histidine kinase BG04_5724 ENOG4105WH1 Two component transcriptional regulator luxr family BG04_5735 ENOG4105EKQ RNA-directed DNA polymerase BG04_5743 ENOG4105K4H Nlp p60 protein BG04_5758 ENOG4108FPN Integrase BG04_5759 ENOG4108HE4 integrase family BG04_5761 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BG04_5764 ENOG4105K70 DNA-binding protein BG04_5765 ENOG4105YWU small acid-soluble spore protein BG04_5778 ENOG4105MYT Heat shock protein BG04_5780 ENOG41090MY MarR family Transcriptional regulator BG04_5781 ENOG4105EUB pirin domain protein BG04_5795 ENOG4105E1K spore germination protein BG04_5798 ENOG4108NA0 Uncharacterized conserved protein (COG2071) BG04_5799 ENOG4105CBC glutamate synthase BG04_5801 ENOG4105C26 Dehydrogenase BG04_5802 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG04_5805 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BG04_5807 ENOG41080HI glycine oxidase BG04_5808 ENOG4105CTU Proline racemase BG04_5809 ENOG4105CTU Proline racemase BG04_581 ENOG4105DJB Major Facilitator Superfamily BG04_5810 ENOG4107QTZ amino acid BG04_5817 ENOG4108UZ3 Transporter BG04_5818 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG04_582 ENOG4105CXK mandelate racemase muconate lactonizing BG04_5824 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BG04_5829 ENOG4108FPN Integrase BG04_584 ENOG4105D7K pfkb domain protein BG04_5846 ENOG4105HHM rdd domain containing protein BG04_585 ENOG4105J4Q Transcriptional regulator BG04_5852 ENOG41087PP glycosyltransferase MGT family BG04_5853 ENOG4105YWU small acid-soluble spore protein BG04_5857 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BG04_5866 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BG04_5882 ENOG4108Z7R Chaperone CsaA BG04_5886 ENOG4108JCI Transcriptional regulator BG04_5893 ENOG4105C94 Transporter BG04_5903 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BG04_5905 ENOG4105C8Q Methyl-accepting chemotaxis BG04_5906 ENOG4105CH6 catalase BG04_5915 ENOG41079KZ Major Facilitator Superfamily BG04_5916 ENOG4105ETE Transcriptional regulator (LacI family BG04_5917 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BG04_5919 ENOG4105EN6 Membrane BG04_5920 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BG04_5921 ENOG4105CF7 AraC family transcriptional regulator BG04_5922 ENOG4105CPC Aldo Keto reductase BG04_5925 ENOG4105DQ6 Transposase BG04_5926 ENOG4105KVH Transcriptional regulator BG04_5929 ENOG4105KVH Transcriptional regulator BG04_5930 ENOG4108VA3 3-hexulose-6-phosphate synthase BG04_5931 ENOG41080HJ 6-phospho 3-hexuloisomerase BG04_5935 ENOG4105D6E homoserine dehydrogenase BG04_5937 ENOG4105C28 cystathionine BG04_5940 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BG04_5942 ENOG4105G9B Transcriptional regulator BG04_5944 ENOG4105BZ1 (ABC) transporter BG04_5946 ENOG4105DQ5 transport system permease protein BG04_5947 ENOG4105EHG Permease protein BG04_5948 ENOG4105E0A ABC, transporter BG04_5952 ENOG4105CIG ABC transporter BG04_5953 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) BG04_5965 ENOG4105DQ6 Transposase BG04_5969 ENOG4105NX3 Membrane BG04_597 ENOG4108JCI Transcriptional regulator BG04_5970 ENOG4105VMP Transcriptional regulator BG04_5979 ENOG4105C7K acetolactate synthase BG04_5980 ENOG4105BZU Histidine kinase BG04_5987 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BG04_599 ENOG4105RHY Pfam:UPF0157 BG04_5993 ENOG4105DQ6 Transposase BG04_5996 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_5998 ENOG4105DHI Methyltransferase BG04_6002 ENOG4105CSH Transporter BG04_606 ENOG4105CHJ isochorismatase hydrolase BG04_608 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BG04_609 ENOG4108VGI doxx family BG04_61 ENOG41060D1 Quinol oxidase BG04_613 ENOG4105FDP GntR family transcriptional regulator BG04_614 ENOG4108KPW sugar kinase BG04_615 ENOG4105CDA abc transporter atp-binding protein BG04_616 ENOG4105E5Q amino acid AbC transporter BG04_617 ENOG4105EAB amino acid AbC transporter BG04_618 ENOG4108JYZ YitT family BG04_622 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_625 ENOG4105ST3 Transcriptional regulator BG04_63 ENOG4105BZ9 Cytochrome C oxidase, subunit I BG04_630 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BG04_631 ENOG4105DWV Homoserine O-trans-acetylase BG04_633 ENOG4105C5Y PTS System BG04_634 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BG04_635 ENOG4108NGU Transcriptional regulator BG04_64 ENOG4105E2S oxidase) subunit II BG04_640 ENOG4108MJ3 acetyltransferase BG04_649 ENOG4107FCW Abortive infection protein BG04_652 ENOG4107RB3 L-asparaginase BG04_656 ENOG4105K7K Transcriptional regulator BG04_658 ENOG4108W5M transcriptional regulator BG04_659 ENOG4105F27 Major Facilitator BG04_660 ENOG4105WDR BG04_661 ENOG4107KM7 Heat induced stress protein YflT BG04_663 ENOG4105C6K Malic enzyme BG04_670 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BG04_675 ENOG4105YWU small acid-soluble spore protein BG04_678 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BG04_679 ENOG4105KPY Small multidrug resistance protein BG04_680 ENOG4105RXJ BG04_682 ENOG4105CG3 alpha amylase, catalytic region BG04_684 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BG04_685 ENOG4105E1K spore germination protein BG04_686 ENOG4108NHD germination protein BG04_696 ENOG4105YWU small acid-soluble spore protein BG04_7 ENOG4107BMA Transglycosylase associated protein BG04_701 ENOG41086D8 Transcriptional regulator BG04_709 ENOG4105DQ6 Transposase BG04_710 ENOG4105CVM Molybdenum cofactor synthesis domain protein BG04_712 ENOG4108RIR Molybdenum cofactor biosynthesis protein BG04_718 ENOG4105C7F AcnD-accessory protein PrpF BG04_719 ENOG4108KAM Transcriptional regulator BG04_724 ENOG4106I4J membrane BG04_725 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BG04_728 ENOG4105K4H Nlp p60 protein BG04_729 ENOG4105CZM Major Facilitator BG04_73 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase BG04_730 ENOG4107MII Sugar-specific transcriptional regulator TrmB BG04_732 ENOG4105QIV RNA polymerase BG04_739 ENOG4105C85 amino acid BG04_740 ENOG4105C26 Dehydrogenase BG04_742 ENOG4108XI2 Domain of unknown function (DUF1963) BG04_746 ENOG4108ZRV stage ii sporulation protein p BG04_748 ENOG4105BZU Histidine kinase BG04_756 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BG04_757 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BG04_767 ENOG4105VUF Transcriptional regulator BG04_768 ENOG4105CPC Aldo Keto reductase BG04_77 ENOG410829K Lysine exporter protein (Lyse ygga) BG04_770 ENOG4107SWG transcriptional regulator MERR family BG04_775 ENOG4108HKT sucrose-6-phosphate hydrolase BG04_78 ENOG4107QTZ amino acid BG04_783 ENOG4105C19 ABC transporter BG04_785 ENOG4105EWM Histidine kinase BG04_786 ENOG4105CJZ response regulator BG04_788 ENOG4105ME7 Membrane BG04_789 ENOG4105XTG Pfam:DUF156 BG04_790 ENOG4105WFK nuclease BG04_792 ENOG4105EEM helicase BG04_794 ENOG4105E39 Enoyl-CoA hydratase BG04_795 ENOG4105KVH Transcriptional regulator BG04_798 ENOG4106A3M Cytochrome p-450 BG04_800 ENOG4105CKK Glycosyl transferase, family 2 BG04_801 ENOG4107QQG Dehydrogenase BG04_802 ENOG4105CKK Glycosyl transferase, family 2 BG04_807 ENOG4106YBV Methyl-accepting chemotaxis BG04_809 ENOG4108P49 AntiSigma factor BG04_810 ENOG4105JVQ RNA Polymerase BG04_812 ENOG4108ZJ4 polysaccharide deacetylase BG04_815 ENOG4108IQI permease BG04_817 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BG04_819 ENOG4105CZN Potassium uptake protein BG04_82 ENOG41087NI Sulfite exporter TauE/SafE BG04_820 ENOG4107ZYR domain protein BG04_824 ENOG4105C0H protease BG04_826 ENOG4105F3H Histidine kinase BG04_828 ENOG4108S4H thioesterase Superfamily protein BG04_829 ENOG4105DRR Transcriptional regulator, GntR family BG04_831 ENOG41064HX Suppressor of fused protein (SUFU) BG04_832 ENOG4105DC7 peptidase M24 BG04_834 ENOG4108RCF TRANSCRIPTIONal BG04_836 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BG04_838 ENOG4105E90 ABC transporter BG04_839 ENOG4108IJ8 ABC transporter BG04_84 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BG04_843 ENOG4105C0R drug resistance transporter emrb qaca subfamily BG04_845 ENOG4105DRS transport system, permease BG04_847 ENOG4107YY3 extracellular solute-binding protein family 1 BG04_849 ENOG4105ETE Transcriptional regulator (LacI family BG04_850 ENOG4108HGU Histidine kinase BG04_851 ENOG4107TSN permease BG04_852 ENOG4105CK2 sodium dicarboxylate symporter BG04_854 ENOG4105EA8 2-Nitropropane dioxygenase BG04_855 ENOG4105CH6 catalase BG04_859 ENOG4108RCF TRANSCRIPTIONal BG04_86 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BG04_860 ENOG4105E0M Sulfatase BG04_863 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BG04_868 ENOG4105JHY Membrane BG04_869 ENOG4105J7D transcriptional regulator BG04_871 ENOG4107RSM transcriptional regulator BG04_873 ENOG4108Z7F N-acetyltransferase BG04_874 ENOG4108RYK Nad-dependent epimerase dehydratase BG04_875 ENOG4105KT7 mgtC SapB transporter BG04_876 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BG04_877 ENOG4105K7W phage-related replication protein BG04_879 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BG04_882 ENOG4105C85 amino acid BG04_892 ENOG4105C1Q protoporphyrinogen oxidase BG04_893 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BG04_894 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) BG04_897 ENOG4105E82 cytochrome subunit of dehydrogenase BG04_9 ENOG4108IJ0 Aspartate ammonia-lyase BG04_901 ENOG4105D64 Mechanosensitive ion channel BG04_902 ENOG4105K4I Scp-like extracellular BG04_903 ENOG4105C37 (CBS) domain BG04_904 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BG04_905 ENOG4107YZX Universal stress protein BG04_907 ENOG4105CTQ phosphohexokinase BG04_91 ENOG4108JYZ YitT family BG04_912 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BG04_915 ENOG4108NHD germination protein BG04_919 ENOG4105DVE abc transporter atp-binding protein BG04_922 ENOG4108JYZ YitT family BG04_925 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BG04_930 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BG04_932 ENOG4105C5Y PTS System BG04_935 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BG04_939 ENOG4105CHH sulfate transporter BG04_940 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BG04_942 ENOG4106Z5R BG04_943 ENOG410841Q phosphoesterase PA-phosphatase related protein BG04_945 ENOG4108N23 SpoOM-related protein BG04_946 ENOG4105D9P serine threonine protein kinase BG04_95 ENOG4108R9S DSBA oxidoreductase BG04_950 ENOG4105VSD UPF0346 protein BG04_951 ENOG4108TGC Acyltransferase BG04_952 ENOG4105F0I Aminotransferase BG04_954 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BG04_955 ENOG4108TSC N-acetyltransferase BG04_956 ENOG4107S4Y M20 DapE family protein YgeY BG04_959 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BG04_96 ENOG4105D0M Protease HtpX homolog BG04_962 ENOG4105BZU Histidine kinase BG04_968 ENOG41090WU lipolytic protein G-D-S-L family BG04_969 ENOG4108KF3 Electron transport protein SCO1 SenC BG04_972 ENOG4108RCR degv family BG04_974 ENOG4105C7B Threonine dehydratase BG04_976 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BG04_977 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BG04_978 ENOG4105CIY formyltetrahydrofolate deformylase BG04_986 ENOG4105DY8 decarboxylase BG04_990 ENOG4105CVP deoxyribo-dipyrimidine photolyase BG04_991 ENOG4105BZU Histidine kinase BG04_995 ENOG4105C26 Dehydrogenase BG04_997 ENOG4108JPW Aminotransferase