locus-tag	class	description
AS52_00019	COG1982	Orn Lys Arg decarboxylase major
AS52_00020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AS52_00021	COG3870	Protein conserved in bacteria
AS52_00022	COG0470	DNA polymerase III
AS52_00023	COG1774	PSP1 C-terminal conserved region
AS52_00024	COG4467	Involved in initiation control of chromosome replication
AS52_00025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AS52_00026	COG2827	Endonuclease containing a URI domain
AS52_00027	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AS52_00028	COG2002	toxin-antitoxin pair type II binding
AS52_00030	COG0084	hydrolase, TatD family'
AS52_00032	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AS52_00034	COG4466	Protein conserved in bacteria
AS52_00037	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS52_00038	COG0251	oxidation-reduction process
AS52_00039	COG2088	sporulation resulting in formation of a cellular spore
AS52_00040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AS52_00041	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AS52_00042	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AS52_00043	COG0193	aminoacyl-tRNA hydrolase activity
AS52_00045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AS52_00046	COG2002	toxin-antitoxin pair type II binding
AS52_00047	COG2244	polysaccharide biosynthetic process
AS52_00048	COG3956	TIGRFAM MazG family protein
AS52_00049	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AS52_00052	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AS52_00053	COG1098	S1 RNA binding domain
AS52_00057	COG2304	oxidoreductase activity
AS52_00058	COG0515	serine threonine protein kinase
AS52_00059	COG0037	tRNA processing
AS52_00061	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS52_00062	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AS52_00063	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AS52_00064	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS52_00065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AS52_00066	COG0512	Glutamine amidotransferase of anthranilate synthase
AS52_00067	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS52_00068	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AS52_00069	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AS52_00070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AS52_00075	COG3880	PFAM UvrB UvrC protein
AS52_00076	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AS52_00077	COG0542	response to heat
AS52_00078	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AS52_00079	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AS52_00080	COG4956	integral membrane protein (PIN domain superfamily)
AS52_00081	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AS52_00083	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS52_00084	COG1045	serine acetyltransferase
AS52_00085	COG0215	cysteine-tRNA ligase activity
AS52_00087	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS52_00088	COG3688	RNA-binding protein containing a PIN domain
AS52_00090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AS52_00091	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS52_00092	COG0250	Participates in transcription elongation, termination and antitermination
AS52_00094	COG0081	regulation of translation
AS52_00095	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AS52_00097	COG2813	Specifically methylates the guanine in position
AS52_00098	COG0085	RNA polymerase activity
AS52_00099	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AS52_00100	COG1358	cellular component organization or biogenesis
AS52_00101	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AS52_00102	COG0049	tRNA binding
AS52_00104	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AS52_00105	COG0051	transcription antitermination factor activity, RNA binding
AS52_00106	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AS52_00107	COG0088	Forms part of the polypeptide exit tunnel
AS52_00108	COG0089	rRNA binding
AS52_00109	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AS52_00110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AS52_00111	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AS52_00112	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AS52_00113	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AS52_00114	COG0255	Belongs to the universal ribosomal protein uL29 family
AS52_00115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AS52_00116	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AS52_00119	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AS52_00123	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AS52_00124	COG1841	ribosomal large subunit assembly
AS52_00126	COG0201	protein transport
AS52_00127	COG0563	adenylate kinase activity
AS52_00128	COG0024	Methionine aminopeptidase
AS52_00129	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AS52_00130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AS52_00131	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AS52_00133	COG0202	RNA polymerase activity
AS52_00134	COG0203	ribosomal protein L17
AS52_00135	COG1122	ATPase activity
AS52_00136	COG1122	ATPase activity
AS52_00137	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AS52_00138	COG0101	tRNA pseudouridine synthase activity
AS52_00139	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AS52_00142	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_00143	COG0489	protein tyrosine kinase activity
AS52_00144	COG0583	DNA-binding transcription factor activity
AS52_00146	COG2194	sulfuric ester hydrolase activity
AS52_00147	COG0726	polysaccharide deacetylase
AS52_00163	COG1595	DNA-templated transcription, initiation
AS52_00164	COG5662	AntiSigma factor
AS52_00165	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AS52_00167	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS52_00168	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AS52_00170	COG3103	Sh3 type 3 domain protein
AS52_00170	COG4991	sh3 domain protein
AS52_00170	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_00171	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_00171	COG2213	PTS system mannitol-specific
AS52_00172	COG3711	transcriptional antiterminator
AS52_00173	COG0246	Mannitol dehydrogenase
AS52_00175	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_00176	COG1970	mechanosensitive ion channel activity
AS52_00177	COG1368	sulfuric ester hydrolase activity
AS52_00180	COG1176	ABC-type spermidine putrescine transport system, permease component I
AS52_00181	COG1177	transmembrane transport
AS52_00182	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AS52_00184	COG0745	RESPONSE REGULATOR receiver
AS52_00185	COG5002	protein histidine kinase activity
AS52_00188	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AS52_00188	COG3976	FMN-binding domain protein
AS52_00189	COG1181	Belongs to the D-alanine--D-alanine ligase family
AS52_00190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AS52_00191	COG0513	Belongs to the DEAD box helicase family
AS52_00192	COG4294	response to UV
AS52_00193	COG0705	Rhomboid family
AS52_00194	COG0736	holo-[acyl-carrier-protein] synthase activity
AS52_00195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AS52_00196	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS52_00197	COG0864	Transcriptional regulator
AS52_00198	COG2337	Toxic component of a toxin-antitoxin (TA) module
AS52_00199	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_00200	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_00201	COG2172	sigma factor antagonist activity
AS52_00202	COG2208	phosphoserine phosphatase activity
AS52_00203	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_00205	COG1191	sigma factor activity
AS52_00206	COG2208	phosphoserine phosphatase activity
AS52_00207	COG2183	response to ionizing radiation
AS52_00225	COG0802	atpase or kinase
AS52_00226	COG1214	PFAM Peptidase M22, glycoprotease
AS52_00227	COG0456	acetyltransferase
AS52_00229	COG0488	(ABC) transporter
AS52_00230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AS52_00231	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS52_00232	COG0805	protein transport
AS52_00234	COG1266	CAAX protease self-immunity
AS52_00235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AS52_00236	COG0459	protein refolding
AS52_00237	COG4974	Belongs to the 'phage' integrase family
AS52_00252	COG0714	Associated with various cellular activities
AS52_00253	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AS52_00254	COG1305	Transglutaminase-like
AS52_00255	COG0519	Catalyzes the synthesis of GMP from XMP
AS52_00255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AS52_00256	COG2252	PERMEase
AS52_00267	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AS52_00268	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AS52_00269	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AS52_00270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AS52_00271	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS52_00272	COG0047	phosphoribosylformylglycinamidine synthase activity
AS52_00273	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS52_00274	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AS52_00275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AS52_00276	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AS52_00277	COG0138	bifunctional purine biosynthesis protein purh
AS52_00278	COG0151	Belongs to the GarS family
AS52_00280	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AS52_00281	COG4496	protein, YerC YecD
AS52_00282	COG0423	glycine-tRNA ligase activity
AS52_00284	COG0210	DNA helicase
AS52_00286	COG4851	CamS sex pheromone cAM373 precursor
AS52_00288	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AS52_00289	COG0154	amidase activity
AS52_00291	COG1597	lipid kinase activity
AS52_00294	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_00296	COG0166	Belongs to the GPI family
AS52_00299	COG3852	Histidine kinase
AS52_00300	COG0024	Methionine aminopeptidase
AS52_00301	COG2706	6-phosphogluconolactonase activity
AS52_00303	COG0789	Transcriptional regulator
AS52_00303	COG4978	Transcriptional regulator
AS52_00304	COG2814	Major facilitator Superfamily
AS52_00306	COG1876	peptidase activity
AS52_00307	COG1126	abc transporter atp-binding protein
AS52_00308	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS52_00309	COG0765	amino acid transport
AS52_00310	COG0765	amino acid transport
AS52_00311	COG1113	amino acid transport
AS52_00312	COG2733	membrane
AS52_00313	COG3212	peptidase
AS52_00314	COG3212	peptidase
AS52_00315	COG5002	protein histidine kinase activity
AS52_00315	COG3850	Histidine kinase
AS52_00316	COG0745	RESPONSE REGULATOR receiver
AS52_00317	COG0671	phosphoesterase, PA-phosphatase related
AS52_00318	COG1764	response to oxidative stress
AS52_00319	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AS52_00321	COG2259	Doxx family
AS52_00322	COG0693	protein deglycase activity
AS52_00323	COG2318	DinB family
AS52_00325	COG1115	amino acid carrier protein
AS52_00328	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AS52_00329	COG0598	Magnesium transport protein CorA
AS52_00330	COG3290	protein histidine kinase activity
AS52_00331	COG4565	transcriptional regulatory protein
AS52_00334	COG4191	Histidine kinase
AS52_00335	COG0513	Belongs to the DEAD box helicase family
AS52_00339	COG4842	Belongs to the WXG100 family
AS52_00340	COG5417	Belongs to the EsaB family
AS52_00341	COG4499	WXG100 protein secretion system (Wss), protein YukC
AS52_00342	COG0433	COG0433 Predicted ATPase
AS52_00342	COG1674	ftsk spoiiie
AS52_00343	COG1511	domain protein
AS52_00346	COG2356	endonuclease I
AS52_00348	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS52_00351	COG0488	(ABC) transporter
AS52_00353	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AS52_00355	COG1959	2 iron, 2 sulfur cluster binding
AS52_00356	COG1017	nitric oxide dioxygenase activity
AS52_00356	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS52_00358	COG0693	protein deglycase activity
AS52_00359	COG2340	Cysteine-rich secretory protein family
AS52_00360	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AS52_00361	COG4840	Belongs to the UPF0435 family
AS52_00362	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AS52_00363	COG4980	gas vesicle protein
AS52_00364	COG1295	ribonuclease BN
AS52_00366	COG2217	Heavy metal translocating P-type atpase
AS52_00368	COG0640	Transcriptional regulator
AS52_00370	COG0477	Major facilitator Superfamily
AS52_00372	COG3479	Phenolic acid decarboxylase
AS52_00374	COG3871	stress protein (general stress protein 26)
AS52_00375	COG0387	Pfam Sodium calcium exchanger
AS52_00377	COG0535	radical SAM domain protein
AS52_00381	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS52_00382	COG0277	FAD linked oxidase domain protein
AS52_00383	COG1113	amino acid transport
AS52_00384	COG5002	protein histidine kinase activity
AS52_00388	COG1090	epimerase
AS52_00390	COG4221	oxidoreductase activity
AS52_00394	COG1988	membrane-bound metal-dependent
AS52_00395	COG1194	a g-specific adenine glycosylase
AS52_00397	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_00400	COG3557	Belongs to the UPF0374 family
AS52_00401	COG1132	(ABC) transporter
AS52_00402	COG4129	membrane
AS52_00403	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AS52_00404	COG4555	ABC transporter
AS52_00408	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AS52_00409	COG0735	belongs to the Fur family
AS52_00432	COG3382	B3 4 domain protein
AS52_00435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AS52_00437	COG2766	serine protein kinase
AS52_00440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AS52_00441	COG0697	spore germination
AS52_00445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AS52_00447	COG1968	undecaprenyl-diphosphatase activity
AS52_00448	COG1301	dicarboxylic acid transport
AS52_00450	COG0586	Pfam SNARE associated Golgi protein
AS52_00451	COG2217	Heavy metal translocating P-type atpase
AS52_00452	COG0531	amino acid
AS52_00456	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AS52_00458	COG1175	transmembrane transport
AS52_00459	COG0395	ABC-type sugar transport system, permease component
AS52_00460	COG1653	transport
AS52_00461	COG0584	glycerophosphoryl diester phosphodiesterase
AS52_00464	COG4948	Mandelate Racemase Muconate Lactonizing
AS52_00473	COG1388	LysM domain
AS52_00473	COG3584	3D domain protein
AS52_00474	COG1876	peptidase activity
AS52_00476	COG3103	Sh3 type 3 domain protein
AS52_00478	COG0456	acetyltransferase
AS52_00478	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_00480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_00486	COG1609	Transcriptional regulator
AS52_00487	COG2814	Major facilitator Superfamily
AS52_00488	COG0673	inositol 2-dehydrogenase activity
AS52_00493	COG1609	Transcriptional regulator
AS52_00494	COG3718	enzyme involved in inositol metabolism
AS52_00497	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_00498	COG1522	sequence-specific DNA binding
AS52_00503	COG0477	Major facilitator Superfamily
AS52_00504	COG1187	pseudouridine synthase activity
AS52_00507	COG1942	4-Oxalocrotonate Tautomerase
AS52_00509	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AS52_00510	COG0747	negative chemotaxis
AS52_00515	COG0084	hydrolase, TatD family'
AS52_00516	COG2962	Rard protein
AS52_00518	COG0628	permease
AS52_00521	COG0604	alcohol dehydrogenase
AS52_00522	COG1620	l-lactate permease
AS52_00524	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AS52_00525	COG0840	transmembrane signaling receptor activity
AS52_00526	COG0564	pseudouridine synthase activity
AS52_00528	COG0673	inositol 2-dehydrogenase activity
AS52_00529	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS52_00530	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_00531	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS52_00531	COG3153	acetyltransferase
AS52_00532	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AS52_00533	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS52_00535	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AS52_00536	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS52_00537	COG1268	BioY protein
AS52_00539	COG2719	SpoVR family
AS52_00541	COG1959	2 iron, 2 sulfur cluster binding
AS52_00542	COG0604	alcohol dehydrogenase
AS52_00544	COG1126	abc transporter atp-binding protein
AS52_00545	COG0765	amino acid transport
AS52_00546	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS52_00547	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS52_00548	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS52_00550	COG0352	thiamine-phosphate diphosphorylase activity
AS52_00551	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS52_00554	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS52_00555	COG0351	phosphomethylpyrimidine kinase
AS52_00558	COG0702	epimerase
AS52_00559	COG1253	flavin adenine dinucleotide binding
AS52_00562	COG3842	ATPase activity
AS52_00563	COG2508	Transcriptional regulator
AS52_00566	COG0189	ligase activity
AS52_00567	COG0189	ligase activity
AS52_00569	COG3679	Belongs to the UPF0342 family
AS52_00570	COG0561	phosphatase activity
AS52_00571	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS52_00572	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_00573	COG1024	Enoyl-CoA hydratase
AS52_00576	COG4152	abc transporter atp-binding protein
AS52_00577	COG1668	transmembrane transport
AS52_00578	COG3481	metal-dependent phosphohydrolase, HD sub domain
AS52_00580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS52_00584	COG1846	Transcriptional regulator
AS52_00587	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AS52_00588	COG1695	Transcriptional regulator
AS52_00589	COG2153	protein acetylation
AS52_00590	COG2755	lipolytic protein G-D-S-L family
AS52_00590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AS52_00591	COG0537	adenosine 5'-monophosphoramidase activity
AS52_00592	COG1131	(ABC) transporter
AS52_00593	COG4473	ABC transporter
AS52_00595	COG1473	amidohydrolase
AS52_00596	COG0671	phosphoesterase, PA-phosphatase related
AS52_00597	COG3069	C4-dicarboxylate transmembrane transporter activity
AS52_00598	COG2329	Antibiotic biosynthesis monooxygenase
AS52_00599	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS52_00600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AS52_00603	COG1309	transcriptional regulator
AS52_00606	COG2972	Histidine kinase
AS52_00609	COG1234	tRNA 3'-trailer cleavage
AS52_00610	COG0095	Lipoate-protein ligase
AS52_00611	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_00612	COG1024	Enoyl-CoA hydratase
AS52_00635	COG0501	Belongs to the peptidase M48B family
AS52_00636	COG2224	Isocitrate lyase
AS52_00638	COG4946	Tricorn protease homolog
AS52_00638	COG1506	peptidase
AS52_00638	COG0823	Involved in the tonB-independent uptake of proteins
AS52_00639	COG0398	Pfam SNARE associated Golgi protein
AS52_00640	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_00641	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AS52_00642	COG1074	ATP-dependent DNA helicase activity
AS52_00643	COG0420	3'-5' exonuclease activity
AS52_00644	COG0419	ATPase involved in DNA repair
AS52_00645	COG1403	HNH endonuclease
AS52_00652	COG2311	Membrane
AS52_00655	COG0367	asparagine synthase
AS52_00658	COG1562	ergosterol biosynthetic process
AS52_00659	COG0347	Belongs to the P(II) protein family
AS52_00660	COG0004	ammonium transporteR
AS52_00661	COG0366	Alpha amylase catalytic
AS52_00661	COG1874	Beta-galactosidase
AS52_00662	COG1609	Transcriptional regulator
AS52_00663	COG1012	belongs to the aldehyde dehydrogenase family
AS52_00664	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AS52_00665	COG4187	Peptidase family M20/M25/M40
AS52_00666	COG0833	amino acid
AS52_00667	COG3829	transcription factor binding
AS52_00668	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_00669	COG1666	GTP binding
AS52_00670	COG2996	Protein conserved in bacteria
AS52_00672	COG1307	EDD domain protein, DegV family
AS52_00673	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_00676	COG0561	phosphatase activity
AS52_00677	COG2151	metal-sulfur cluster biosynthetic enzyme
AS52_00678	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS52_00679	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AS52_00680	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AS52_00681	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AS52_00685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AS52_00688	COG0542	response to heat
AS52_00691	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AS52_00692	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AS52_00693	COG2084	Dehydrogenase
AS52_00695	COG2267	carboxylic ester hydrolase activity
AS52_00699	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS52_00700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AS52_00701	COG5504	Zn-dependent protease
AS52_00702	COG0444	Belongs to the ABC transporter superfamily
AS52_00703	COG4608	Belongs to the ABC transporter superfamily
AS52_00705	COG0601	transmembrane transport
AS52_00709	COG0180	Tryptophanyl-tRNA synthetase
AS52_00710	COG4166	transmembrane transport
AS52_00711	COG0601	transmembrane transport
AS52_00712	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS52_00713	COG0444	Belongs to the ABC transporter superfamily
AS52_00714	COG4608	Belongs to the ABC transporter superfamily
AS52_00715	COG0456	acetyltransferase
AS52_00716	COG1113	amino acid transport
AS52_00717	COG0531	amino acid
AS52_00718	COG1393	Belongs to the ArsC family
AS52_00719	COG0583	DNA-binding transcription factor activity
AS52_00722	COG0861	Integral membrane protein TerC family
AS52_00724	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_00726	COG1164	Oligoendopeptidase f
AS52_00729	COG2346	COG2346, Truncated hemoglobins
AS52_00730	COG0741	lytic transglycosylase activity
AS52_00731	COG4116	CYTH
AS52_00733	COG2357	RelA SpoT domain protein
AS52_00734	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AS52_00735	COG0564	pseudouridine synthase activity
AS52_00737	COG2239	Acts as a magnesium transporter
AS52_00738	COG0475	glutathione-regulated potassium exporter activity
AS52_00738	COG0569	domain protein
AS52_00749	COG0210	DNA helicase
AS52_00751	COG2323	membrane
AS52_00752	COG2153	protein acetylation
AS52_00754	COG2382	esterase
AS52_00756	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AS52_00758	COG1737	Transcriptional regulator
AS52_00759	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AS52_00760	COG1070	Carbohydrate kinase
AS52_00761	COG1953	Uracil, thiamine, allantoin
AS52_00765	COG1522	sequence-specific DNA binding
AS52_00770	COG1131	(ABC) transporter
AS52_00774	COG3142	Participates in the control of copper homeostasis
AS52_00775	COG1113	amino acid transport
AS52_00777	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_00778	COG1309	transcriptional regulator
AS52_00779	COG3711	transcriptional antiterminator
AS52_00779	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_00780	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS52_00781	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS52_00782	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS52_00783	COG1486	melibiose metabolic process
AS52_00784	COG2204	response regulator
AS52_00787	COG3275	phosphorelay sensor kinase activity
AS52_00788	COG3279	Response regulator of the LytR AlgR family
AS52_00790	COG1346	cytolysis
AS52_00793	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS52_00794	COG0243	molybdopterin cofactor binding
AS52_00795	COG2223	nitrite transmembrane transporter activity
AS52_00796	COG3527	Alpha-acetolactate decarboxylase
AS52_00797	COG0028	Belongs to the TPP enzyme family
AS52_00799	COG4895	conserved protein (DUF2196)
AS52_00801	COG1733	regulation of RNA biosynthetic process
AS52_00802	COG2814	Major facilitator Superfamily
AS52_00803	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_00807	COG3052	prosthetic group binding
AS52_00810	COG0784	Response regulator, receiver
AS52_00811	COG4191	Histidine kinase
AS52_00812	COG2066	Belongs to the glutaminase family
AS52_00813	COG1115	amino acid carrier protein
AS52_00814	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS52_00816	COG4297	protein containing double-stranded beta helix domain
AS52_00817	COG0531	amino acid
AS52_00819	COG1607	acyl-coa hydrolase
AS52_00820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AS52_00823	COG0390	transport system, permease component
AS52_00824	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AS52_00827	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS52_00828	COG1136	(ABC) transporter
AS52_00829	COG0577	efflux transmembrane transporter activity
AS52_00831	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AS52_00834	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS52_00835	COG0833	amino acid
AS52_00837	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AS52_00838	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS52_00840	COG0861	Integral membrane protein TerC family
AS52_00841	COG1301	dicarboxylic acid transport
AS52_00842	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AS52_00843	COG3290	protein histidine kinase activity
AS52_00850	COG0523	cobalamin synthesis protein
AS52_00854	COG1063	alcohol dehydrogenase
AS52_00859	COG1476	TRANSCRIPTIONal
AS52_00861	COG1368	sulfuric ester hydrolase activity
AS52_00864	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_00865	COG2040	homocysteine
AS52_00866	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS52_00869	COG2851	Citrate transporter
AS52_00870	COG3290	protein histidine kinase activity
AS52_00871	COG4565	transcriptional regulatory protein
AS52_00872	COG3181	Tripartite tricarboxylate transporter family receptor
AS52_00873	COG0583	DNA-binding transcription factor activity
AS52_00874	COG3180	Ammonia monooxygenase
AS52_00875	COG2226	methyltransferase
AS52_00876	COG4176	ABC-type proline glycine betaine transport system permease component
AS52_00877	COG4175	Glycine betaine
AS52_00877	COG0517	IMP dehydrogenase activity
AS52_00878	COG2113	Glycine betaine
AS52_00879	COG1309	transcriptional regulator
AS52_00883	COG0531	amino acid
AS52_00884	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS52_00887	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_00889	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AS52_00890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_00891	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_00897	COG1737	Transcriptional regulator
AS52_00898	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_00898	COG1263	PTS System
AS52_00901	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS52_00902	COG2271	Major facilitator Superfamily
AS52_00903	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS52_00904	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS52_00905	COG1116	anion transmembrane transporter activity
AS52_00906	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS52_00907	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS52_00909	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AS52_00910	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AS52_00911	COG1733	regulation of RNA biosynthetic process
AS52_00919	COG1511	domain protein
AS52_00920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AS52_00921	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AS52_00922	COG1733	regulation of RNA biosynthetic process
AS52_00924	COG1132	(ABC) transporter
AS52_00925	COG1132	(ABC) transporter
AS52_00927	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS52_00928	COG3162	membrane
AS52_00930	COG1414	Transcriptional regulator
AS52_00931	COG0656	L-ascorbic acid biosynthetic process
AS52_00932	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AS52_00933	COG1846	Transcriptional regulator
AS52_00934	COG1566	PFAM secretion protein HlyD family protein
AS52_00935	COG2814	Major facilitator Superfamily
AS52_00936	COG0655	NAD(P)H dehydrogenase (quinone) activity
AS52_00939	COG1609	Transcriptional regulator
AS52_00940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS52_00942	COG1129	ABC transporter
AS52_00943	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS52_00944	COG1879	ABC-type sugar transport system periplasmic component
AS52_00945	COG3584	3D domain protein
AS52_00945	COG1388	LysM domain
AS52_00946	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS52_00947	COG1653	transport
AS52_00952	COG3706	GGDEF domain
AS52_00952	COG0745	RESPONSE REGULATOR receiver
AS52_00956	COG0745	RESPONSE REGULATOR receiver
AS52_00957	COG5002	protein histidine kinase activity
AS52_00965	COG0402	S-adenosylhomocysteine deaminase activity
AS52_00966	COG2252	PERMEase
AS52_00967	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AS52_00969	COG1263	PTS System
AS52_00969	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_00970	COG0366	Alpha amylase catalytic
AS52_00971	COG2188	Transcriptional regulator
AS52_00972	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AS52_00973	COG1984	allophanate hydrolase subunit 2
AS52_00974	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AS52_00975	COG1914	H( )-stimulated, divalent metal cation uptake system
AS52_00976	COG1272	protein, Hemolysin III
AS52_00979	COG0778	Nitroreductase
AS52_00980	COG0628	permease
AS52_00985	COG0439	Biotin carboxylase
AS52_00988	COG0531	amino acid
AS52_00989	COG0402	S-adenosylhomocysteine deaminase activity
AS52_00990	COG1278	Cold shock
AS52_00991	COG2910	NAD(P)H-binding
AS52_00992	COG0673	inositol 2-dehydrogenase activity
AS52_00993	COG0450	alkyl hydroperoxide reductase
AS52_00994	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_00998	COG2203	Gaf domain
AS52_00998	COG3706	GGDEF domain
AS52_00998	COG4251	negative regulation of phosphorylation
AS52_00998	COG5001	Diguanylate cyclase
AS52_00999	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS52_01000	COG2076	Multidrug Resistance protein
AS52_01001	COG2076	Multidrug Resistance protein
AS52_01015	COG1649	PFAM Uncharacterised BCR, COG1649
AS52_01016	COG1737	Transcriptional regulator
AS52_01020	COG1486	melibiose metabolic process
AS52_01022	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS52_01024	COG2971	BadF BadG BcrA BcrD
AS52_01025	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AS52_01027	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AS52_01030	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_01031	COG2226	methyltransferase
AS52_01032	COG0583	DNA-binding transcription factor activity
AS52_01034	COG0667	Aldo Keto reductase
AS52_01037	COG0154	amidase activity
AS52_01040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS52_01053	COG2200	EAL domain
AS52_01053	COG2199	diguanylate cyclase activity
AS52_01055	COG1733	regulation of RNA biosynthetic process
AS52_01058	COG0385	Bile acid
AS52_01060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS52_01062	COG4191	Histidine kinase
AS52_01063	COG0784	Response regulator, receiver
AS52_01066	COG1388	LysM domain
AS52_01066	COG0791	NLP P60 protein
AS52_01068	COG2385	sporulation resulting in formation of a cellular spore
AS52_01069	COG0656	L-ascorbic acid biosynthetic process
AS52_01072	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS52_01073	COG4948	Mandelate Racemase Muconate Lactonizing
AS52_01079	COG0477	Major facilitator Superfamily
AS52_01080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS52_01082	COG0640	Transcriptional regulator
AS52_01083	COG5658	integral membrane protein
AS52_01088	COG3300	MHYT domain
AS52_01088	COG5001	Diguanylate cyclase
AS52_01089	COG0302	gtp cyclohydrolase
AS52_01092	COG3300	MHYT domain
AS52_01092	COG5001	Diguanylate cyclase
AS52_01095	COG0464	growth
AS52_01097	COG0443	Heat shock 70 kDa protein
AS52_01099	COG0484	heat shock protein binding
AS52_01109	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AS52_01111	COG1396	sequence-specific DNA binding
AS52_01115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AS52_01119	COG1215	transferase activity, transferring glycosyl groups
AS52_01122	COG0840	transmembrane signaling receptor activity
AS52_01124	COG2385	sporulation resulting in formation of a cellular spore
AS52_01124	COG2247	cell wall binding repeat
AS52_01130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS52_01131	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AS52_01132	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS52_01133	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AS52_01135	COG0110	maltose O-acetyltransferase activity
AS52_01137	COG1215	transferase activity, transferring glycosyl groups
AS52_01142	COG0110	maltose O-acetyltransferase activity
AS52_01144	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AS52_01147	COG1482	cell wall glycoprotein biosynthetic process
AS52_01148	COG3944	biosynthesis protein
AS52_01149	COG0489	protein tyrosine kinase activity
AS52_01150	COG4464	protein tyrosine phosphatase activity
AS52_01152	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AS52_01153	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS52_01160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AS52_01161	COG1682	transport, permease protein
AS52_01162	COG1134	teichoic acid transport
AS52_01164	COG1316	TRANSCRIPTIONal
AS52_01167	COG4464	protein tyrosine phosphatase activity
AS52_01169	COG0028	Belongs to the TPP enzyme family
AS52_01170	COG0069	glutamate synthase activity
AS52_01172	COG2084	Dehydrogenase
AS52_01178	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS52_01179	COG2146	nitrite reductase [NAD(P)H] activity
AS52_01181	COG2116	formate transmembrane transporter activity
AS52_01183	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS52_01184	COG4975	Glucose uptake
AS52_01187	COG0534	Mate efflux family protein
AS52_01189	COG0277	FAD linked oxidase domain protein
AS52_01190	COG1316	TRANSCRIPTIONal
AS52_01193	COG0598	Magnesium transport protein CorA
AS52_01194	COG1404	Belongs to the peptidase S8 family
AS52_01197	COG0454	-acetyltransferase
AS52_01197	COG0456	acetyltransferase
AS52_01198	COG4821	SIS domain
AS52_01200	COG0363	glucosamine-6-phosphate deaminase activity
AS52_01201	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AS52_01202	COG1263	PTS System
AS52_01202	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_01202	COG2190	(PTS) system
AS52_01203	COG1811	Na channel or pump
AS52_01210	COG1131	(ABC) transporter
AS52_01211	COG1253	flavin adenine dinucleotide binding
AS52_01212	COG0789	Transcriptional regulator
AS52_01214	COG0346	lactoylglutathione lyase activity
AS52_01215	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AS52_01215	COG2105	PFAM AIG2 family protein
AS52_01221	COG0840	transmembrane signaling receptor activity
AS52_01227	COG4187	Peptidase family M20/M25/M40
AS52_01230	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS52_01230	COG0456	acetyltransferase
AS52_01233	COG2252	PERMEase
AS52_01235	COG3279	Response regulator of the LytR AlgR family
AS52_01236	COG4555	ABC transporter
AS52_01237	COG1668	transmembrane transport
AS52_01239	COG0789	Transcriptional regulator
AS52_01240	COG1846	Transcriptional regulator
AS52_01241	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS52_01241	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS52_01245	COG1785	Belongs to the alkaline phosphatase family
AS52_01246	COG3279	Response regulator of the LytR AlgR family
AS52_01247	COG0784	Response regulator, receiver
AS52_01247	COG2205	protein histidine kinase activity
AS52_01248	COG0861	Integral membrane protein TerC family
AS52_01249	COG1191	sigma factor activity
AS52_01255	COG3243	poly(R)-hydroxyalkanoic acid synthase
AS52_01256	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS52_01260	COG2186	Transcriptional regulator
AS52_01261	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AS52_01263	COG0247	lactate metabolic process
AS52_01264	COG1139	Iron-sulfur cluster binding protein
AS52_01265	COG1556	Lactate utilization protein
AS52_01266	COG5002	protein histidine kinase activity
AS52_01267	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS52_01269	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AS52_01270	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AS52_01271	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS52_01272	COG0436	Aminotransferase
AS52_01273	COG1850	ribulose-bisphosphate carboxylase activity
AS52_01274	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AS52_01275	COG0235	Class ii aldolase
AS52_01276	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AS52_01278	COG1129	ABC transporter
AS52_01279	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS52_01284	COG1846	Transcriptional regulator
AS52_01286	COG4191	Histidine kinase
AS52_01288	COG0542	response to heat
AS52_01292	COG0300	oxidoreductase activity
AS52_01293	COG0697	spore germination
AS52_01297	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AS52_01298	COG0720	synthase
AS52_01300	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AS52_01301	COG0702	epimerase
AS52_01303	COG4873	Protein conserved in bacteria
AS52_01307	COG3773	Cell wall hydrolase
AS52_01315	COG1410	methionine synthase
AS52_01315	COG0646	methionine synthase
AS52_01316	COG0646	methionine synthase
AS52_01316	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AS52_01317	COG3949	Membrane
AS52_01318	COG0307	riboflavin synthase, alpha
AS52_01320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AS52_01322	COG3711	transcriptional antiterminator
AS52_01323	COG2190	(PTS) system
AS52_01323	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_01323	COG1263	PTS System
AS52_01326	COG1346	cytolysis
AS52_01328	COG0583	DNA-binding transcription factor activity
AS52_01330	COG0456	acetyltransferase
AS52_01331	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_01332	COG0778	Nitroreductase
AS52_01333	COG0436	Aminotransferase
AS52_01337	COG0835	chemotaxis
AS52_01337	COG0784	Response regulator, receiver
AS52_01339	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_01340	COG0248	Ppx GppA phosphatase
AS52_01343	COG1408	metallophosphoesterase
AS52_01344	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_01345	COG2200	EAL domain
AS52_01348	COG4703	Protein of unknown function (DUF1797)
AS52_01349	COG0517	IMP dehydrogenase activity
AS52_01350	COG0583	DNA-binding transcription factor activity
AS52_01351	COG2171	N-acyltransferase activity
AS52_01352	COG1473	amidohydrolase
AS52_01354	COG0668	transmembrane transport
AS52_01355	COG0450	alkyl hydroperoxide reductase
AS52_01356	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_01357	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AS52_01358	COG1132	(ABC) transporter
AS52_01359	COG1132	(ABC) transporter
AS52_01360	COG0569	domain protein
AS52_01361	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS52_01363	COG0561	phosphatase activity
AS52_01368	COG0022	dehydrogenase e1 component
AS52_01369	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS52_01372	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS52_01374	COG1982	Orn Lys Arg decarboxylase major
AS52_01375	COG4476	Belongs to the UPF0223 family
AS52_01376	COG4493	Belongs to the UPF0637 family
AS52_01378	COG0483	inositol monophosphate 1-phosphatase activity
AS52_01383	COG4896	Protein conserved in bacteria
AS52_01386	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AS52_01387	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AS52_01388	COG4838	Belongs to the UPF0358 family
AS52_01389	COG0772	Belongs to the SEDS family
AS52_01390	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AS52_01391	COG1612	heme a metabolic process
AS52_01392	COG0109	protoheme IX farnesyltransferase activity
AS52_01397	COG3336	cytochrome c oxidase
AS52_01399	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AS52_01400	COG2340	Cysteine-rich secretory protein family
AS52_01402	COG2738	Putative neutral zinc metallopeptidase
AS52_01403	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_01404	COG1694	Mazg nucleotide pyrophosphohydrolase
AS52_01405	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AS52_01406	COG1803	Methylglyoxal synthase
AS52_01407	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS52_01408	COG0438	transferase activity, transferring glycosyl groups
AS52_01409	COG0617	tRNA 3'-terminal CCA addition
AS52_01410	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AS52_01410	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AS52_01412	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AS52_01413	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AS52_01414	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AS52_01414	COG1199	ATP-dependent helicase activity
AS52_01418	COG0436	Aminotransferase
AS52_01419	COG0017	Asparaginyl-tRNA synthetase
AS52_01420	COG3935	DnaD domain protein
AS52_01421	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AS52_01423	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS52_01423	COG4499	WXG100 protein secretion system (Wss), protein YukC
AS52_01424	COG3331	DNA recombination
AS52_01434	COG5337	Spore coat protein CotH
AS52_01437	COG0626	cystathionine gamma-synthase activity
AS52_01438	COG0626	cystathionine gamma-synthase activity
AS52_01441	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS52_01444	COG1278	Cold shock
AS52_01447	COG3706	GGDEF domain
AS52_01449	COG1205	dead DEAH box helicase
AS52_01449	COG1111	helicase
AS52_01450	COG3359	exonuclease
AS52_01452	COG4474	Belongs to the UPF0398 family
AS52_01453	COG3599	regulation of cell shape
AS52_01458	COG2197	response regulator
AS52_01459	COG0366	Alpha amylase catalytic
AS52_01460	COG0116	Belongs to the methyltransferase superfamily
AS52_01463	COG1175	transmembrane transport
AS52_01465	COG3842	ATPase activity
AS52_01467	COG1199	ATP-dependent helicase activity
AS52_01468	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AS52_01469	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS52_01470	COG2233	PERMEase
AS52_01471	COG0583	DNA-binding transcription factor activity
AS52_01472	COG1012	belongs to the aldehyde dehydrogenase family
AS52_01474	COG3424	synthase
AS52_01475	COG1755	Isoprenylcysteine carboxyl methyltransferase
AS52_01476	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AS52_01477	COG3541	Predicted nucleotidyltransferase
AS52_01482	COG0328	RNA-DNA hybrid ribonuclease activity
AS52_01483	COG0328	RNA-DNA hybrid ribonuclease activity
AS52_01488	COG2814	Major facilitator Superfamily
AS52_01490	COG2233	PERMEase
AS52_01491	COG2362	D-Aminopeptidase
AS52_01492	COG0601	transmembrane transport
AS52_01493	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS52_01494	COG0444	Belongs to the ABC transporter superfamily
AS52_01495	COG4166	transmembrane transport
AS52_01496	COG1619	proteins homologs of microcin C7 resistance protein MccF
AS52_01497	COG0791	NLP P60 protein
AS52_01498	COG4608	Belongs to the ABC transporter superfamily
AS52_01502	COG5001	Diguanylate cyclase
AS52_01502	COG3300	MHYT domain
AS52_01503	COG3689	TIGRFAM TIGR03943 family protein
AS52_01504	COG0701	Predicted permease
AS52_01505	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AS52_01506	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_01507	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_01508	COG1120	ATPase activity
AS52_01515	COG2197	response regulator
AS52_01516	COG4585	Histidine kinase
AS52_01517	COG3239	Fatty acid desaturase
AS52_01518	COG2205	protein histidine kinase activity
AS52_01519	COG2205	protein histidine kinase activity
AS52_01521	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_01524	COG1388	LysM domain
AS52_01524	COG0791	NLP P60 protein
AS52_01525	COG1819	glycosyl
AS52_01526	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS52_01528	COG2814	Major facilitator Superfamily
AS52_01530	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_01532	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AS52_01533	COG1404	Belongs to the peptidase S8 family
AS52_01535	COG1846	Transcriptional regulator
AS52_01536	COG1566	PFAM secretion protein HlyD family protein
AS52_01537	COG2814	Major facilitator Superfamily
AS52_01542	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_01543	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_01544	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS52_01545	COG1120	ATPase activity
AS52_01548	COG2814	Major facilitator Superfamily
AS52_01552	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS52_01553	COG1733	regulation of RNA biosynthetic process
AS52_01554	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AS52_01556	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS52_01558	COG3448	diguanylate cyclase activity
AS52_01558	COG4175	Glycine betaine
AS52_01561	COG0469	pyruvate kinase activity
AS52_01563	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AS52_01564	COG2208	phosphoserine phosphatase activity
AS52_01566	COG0531	amino acid
AS52_01568	COG1011	Hydrolase
AS52_01569	COG0405	Gamma-glutamyltransferase
AS52_01570	COG1621	beta-fructofuranosidase activity
AS52_01571	COG1621	beta-fructofuranosidase activity
AS52_01572	COG2193	ferroxidase activity
AS52_01573	COG0477	Major facilitator Superfamily
AS52_01574	COG0156	8-amino-7-oxononanoate synthase activity
AS52_01575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS52_01577	COG2814	Major facilitator Superfamily
AS52_01580	COG1012	belongs to the aldehyde dehydrogenase family
AS52_01582	COG1280	lysine exporter protein (LysE YggA)
AS52_01583	COG1113	amino acid transport
AS52_01586	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS52_01591	COG1113	amino acid transport
AS52_01594	COG1609	Transcriptional regulator
AS52_01595	COG2223	nitrite transmembrane transporter activity
AS52_01597	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AS52_01598	COG1621	beta-fructofuranosidase activity
AS52_01599	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AS52_01599	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AS52_01600	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_01601	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_01602	COG3715	PTS system
AS52_01603	COG3716	PTS system mannose fructose sorbose family IID component
AS52_01604	COG1621	beta-fructofuranosidase activity
AS52_01608	COG1464	Belongs to the NlpA lipoprotein family
AS52_01609	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS52_01610	COG2011	ABC-type metal ion transport system permease component
AS52_01611	COG1464	Belongs to the NlpA lipoprotein family
AS52_01613	COG0024	Methionine aminopeptidase
AS52_01616	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AS52_01618	COG0656	L-ascorbic acid biosynthetic process
AS52_01619	COG2986	histidine ammonia-lyase
AS52_01621	COG1228	amidohydrolase
AS52_01622	COG0010	Belongs to the arginase family
AS52_01623	COG1846	Transcriptional regulator
AS52_01625	COG1957	nucleoside hydrolase
AS52_01626	COG1288	antiporter activity
AS52_01627	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AS52_01632	COG4221	oxidoreductase activity
AS52_01633	COG0789	Transcriptional regulator
AS52_01635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_01638	COG2364	Membrane
AS52_01639	COG1846	Transcriptional regulator
AS52_01640	COG0456	acetyltransferase
AS52_01641	COG0640	Transcriptional regulator
AS52_01655	COG2190	(PTS) system
AS52_01655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_01655	COG1263	PTS System
AS52_01656	COG2723	6-phospho-beta-galactosidase activity
AS52_01659	COG3848	Pyruvate phosphate dikinase
AS52_01659	COG0574	Belongs to the PEP-utilizing enzyme family
AS52_01660	COG1309	transcriptional regulator
AS52_01661	COG2814	Major facilitator Superfamily
AS52_01664	COG0494	nUDIX hydrolase
AS52_01668	COG1388	LysM domain
AS52_01668	COG0791	NLP P60 protein
AS52_01672	COG2318	DinB family
AS52_01679	COG0583	DNA-binding transcription factor activity
AS52_01685	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_01689	COG0586	Pfam SNARE associated Golgi protein
AS52_01691	COG0726	polysaccharide deacetylase
AS52_01694	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS52_01696	COG0697	spore germination
AS52_01697	COG4977	sequence-specific DNA binding
AS52_01703	COG0387	Pfam Sodium calcium exchanger
AS52_01704	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_01710	COG1309	transcriptional regulator
AS52_01711	COG0861	Integral membrane protein TerC family
AS52_01712	COG2188	Transcriptional regulator
AS52_01713	COG1447	Phosphotransferase system cellobiose-specific component IIA
AS52_01715	COG2723	6-phospho-beta-galactosidase activity
AS52_01717	COG1940	carbohydrate kinase activity
AS52_01719	COG1522	sequence-specific DNA binding
AS52_01728	COG2076	Multidrug Resistance protein
AS52_01738	COG1278	Cold shock
AS52_01740	COG0028	Belongs to the TPP enzyme family
AS52_01748	COG2172	sigma factor antagonist activity
AS52_01749	COG1388	LysM domain
AS52_01749	COG3858	chitin binding
AS52_01750	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_01757	COG2226	methyltransferase
AS52_01759	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_01762	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS52_01763	COG0640	Transcriptional regulator
AS52_01765	COG0640	Transcriptional regulator
AS52_01766	COG0346	lactoylglutathione lyase activity
AS52_01767	COG5553	Cysteine dioxygenase type I
AS52_01768	COG0697	spore germination
AS52_01769	COG1733	regulation of RNA biosynthetic process
AS52_01770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_01772	COG2207	Transcriptional regulator
AS52_01774	COG2376	Dihydroxyacetone kinase
AS52_01780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS52_01799	COG1266	CAAX protease self-immunity
AS52_01802	COG2814	Major facilitator Superfamily
AS52_01803	COG0789	Transcriptional regulator
AS52_01804	COG0667	Aldo Keto reductase
AS52_01834	COG2801	Transposase and inactivated derivatives
AS52_01838	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS52_01840	COG4282	regulation of fungal-type cell wall biogenesis
AS52_01846	COG3848	Pyruvate phosphate dikinase
AS52_01846	COG0574	Belongs to the PEP-utilizing enzyme family
AS52_01847	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AS52_01849	COG0601	transmembrane transport
AS52_01851	COG0444	Belongs to the ABC transporter superfamily
AS52_01852	COG4608	Belongs to the ABC transporter superfamily
AS52_01853	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AS52_01856	COG3852	Histidine kinase
AS52_01857	COG4191	Histidine kinase
AS52_01858	COG2204	response regulator
AS52_01860	COG0477	Major facilitator Superfamily
AS52_01861	COG0300	oxidoreductase activity
AS52_01864	COG1012	belongs to the aldehyde dehydrogenase family
AS52_01867	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS52_01868	COG1454	alcohol dehydrogenase
AS52_01870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AS52_01873	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_01881	COG0517	IMP dehydrogenase activity
AS52_01884	COG1309	transcriptional regulator
AS52_01887	COG1070	Carbohydrate kinase
AS52_01888	COG0477	Major facilitator Superfamily
AS52_01888	COG2814	Major facilitator Superfamily
AS52_01890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AS52_01891	COG1845	cytochrome c oxidase, subunit III
AS52_01892	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AS52_01893	COG0589	response to stress
AS52_01894	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_01895	COG1612	heme a metabolic process
AS52_01896	COG2072	flavoprotein involved in K transport
AS52_01898	COG2252	PERMEase
AS52_01899	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS52_01900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS52_01901	COG0022	dehydrogenase e1 component
AS52_01902	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS52_01903	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS52_01904	COG3284	Transcriptional regulator
AS52_01906	COG1846	Transcriptional regulator
AS52_01914	COG0628	permease
AS52_01915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS52_01916	COG1904	glucuronate isomerase
AS52_01917	COG2211	Major facilitator Superfamily
AS52_01918	COG1609	Transcriptional regulator
AS52_01919	COG0246	Mannitol dehydrogenase
AS52_01920	COG2721	sulfolactate sulfo-lyase activity
AS52_01923	COG2211	Major facilitator Superfamily
AS52_01927	COG0589	response to stress
AS52_01928	COG5002	protein histidine kinase activity
AS52_01929	COG0745	RESPONSE REGULATOR receiver
AS52_01930	COG1937	Protein conserved in bacteria
AS52_01931	COG2608	mercury ion transmembrane transporter activity
AS52_01932	COG2217	Heavy metal translocating P-type atpase
AS52_01934	COG1388	LysM domain
AS52_01935	COG2271	Major facilitator Superfamily
AS52_01943	COG0640	Transcriptional regulator
AS52_01944	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AS52_01946	COG2050	protein possibly involved in aromatic compounds catabolism
AS52_01947	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AS52_01948	COG2323	membrane
AS52_01951	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS52_01952	COG0473	3-isopropylmalate dehydrogenase activity
AS52_01953	COG2814	Major facilitator Superfamily
AS52_01954	COG1733	regulation of RNA biosynthetic process
AS52_01955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS52_01955	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS52_01956	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS52_01956	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS52_01961	COG2226	methyltransferase
AS52_01964	COG5566	PFAM Mor transcription activator
AS52_01967	COG0561	phosphatase activity
AS52_01968	COG1876	peptidase activity
AS52_01970	COG0726	polysaccharide deacetylase
AS52_01978	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AS52_01981	COG0386	Belongs to the glutathione peroxidase family
AS52_01982	COG1418	mRNA catabolic process
AS52_01983	COG0488	(ABC) transporter
AS52_01984	COG1413	lyase activity
AS52_01985	COG0726	polysaccharide deacetylase
AS52_01987	COG2136	Putative SAM-dependent methyltransferase
AS52_01987	COG2521	methyltransferase
AS52_01989	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_01990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS52_01992	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AS52_01994	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
AS52_01995	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AS52_01996	COG0406	alpha-ribazole phosphatase activity
AS52_01998	COG2096	Adenosyltransferase
AS52_01999	COG2962	Rard protein
AS52_02003	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AS52_02004	COG0322	excinuclease ABC activity
AS52_02006	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS52_02007	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS52_02008	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AS52_02010	COG3011	Protein conserved in bacteria
AS52_02011	COG1595	DNA-templated transcription, initiation
AS52_02015	COG2002	toxin-antitoxin pair type II binding
AS52_02016	COG0534	Mate efflux family protein
AS52_02022	COG1368	sulfuric ester hydrolase activity
AS52_02024	COG3853	Toxic anion resistance protein (TelA)
AS52_02028	COG0726	polysaccharide deacetylase
AS52_02030	COG2234	aminopeptidase activity
AS52_02031	COG5002	protein histidine kinase activity
AS52_02033	COG1823	symporter activity
AS52_02034	COG1523	belongs to the glycosyl hydrolase 13 family
AS52_02035	COG1012	belongs to the aldehyde dehydrogenase family
AS52_02036	COG2124	cytochrome p450
AS52_02037	COG2112	serine threonine protein kinase
AS52_02040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AS52_02041	COG1360	Flagellar Motor Protein
AS52_02044	COG3361	conserved protein (COG2071)
AS52_02045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS52_02046	COG1757	Na H antiporter
AS52_02048	COG0833	amino acid
AS52_02049	COG3594	Acyltransferase
AS52_02050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS52_02052	COG0745	RESPONSE REGULATOR receiver
AS52_02053	COG5002	protein histidine kinase activity
AS52_02054	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AS52_02055	COG3104	oligopeptide transport
AS52_02057	COG0281	malic enzyme
AS52_02058	COG3493	citrate carrier protein
AS52_02059	COG0561	phosphatase activity
AS52_02060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_02063	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AS52_02064	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS52_02065	COG0765	amino acid transport
AS52_02066	COG0765	amino acid transport
AS52_02067	COG1126	abc transporter atp-binding protein
AS52_02068	COG0196	riboflavin kinase activity
AS52_02069	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_02071	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_02076	COG1070	Carbohydrate kinase
AS52_02077	COG2140	Oxalate decarboxylase
AS52_02078	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS52_02082	COG0363	glucosamine-6-phosphate deaminase activity
AS52_02083	COG0738	Major facilitator superfamily
AS52_02088	COG1611	Belongs to the LOG family
AS52_02089	COG0281	malic enzyme
AS52_02090	COG3402	PFAM membrane-flanked domain
AS52_02091	COG3428	Bacterial PH domain
AS52_02094	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS52_02095	COG0109	protoheme IX farnesyltransferase activity
AS52_02096	COG4195	phage-related replication protein
AS52_02099	COG0789	Transcriptional regulator
AS52_02106	COG0583	DNA-binding transcription factor activity
AS52_02107	COG0067	glutamate synthase
AS52_02107	COG0069	glutamate synthase activity
AS52_02107	COG0070	glutamate synthase
AS52_02108	COG0493	'glutamate synthase
AS52_02112	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AS52_02115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_02117	COG1846	Transcriptional regulator
AS52_02118	COG1380	Effector of murein hydrolase LrgA
AS52_02119	COG1346	cytolysis
AS52_02120	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_02122	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AS52_02123	COG0463	Glycosyl transferase, family 2
AS52_02124	COG2246	polysaccharide biosynthetic process
AS52_02125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS52_02126	COG0745	RESPONSE REGULATOR receiver
AS52_02128	COG5583	Uncharacterized small protein (DUF2292)
AS52_02130	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AS52_02132	COG4208	sulfate ABC transporter
AS52_02135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_02138	COG1349	DNA-binding transcription factor activity
AS52_02139	COG1105	Belongs to the carbohydrate kinase PfkB family
AS52_02140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_02140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS52_02140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AS52_02141	COG0527	aspartate kinase activity
AS52_02143	COG2032	superoxide dismutase activity
AS52_02144	COG1233	COG1233 Phytoene dehydrogenase and related
AS52_02146	COG0300	oxidoreductase activity
AS52_02147	COG0640	Transcriptional regulator
AS52_02148	COG1012	belongs to the aldehyde dehydrogenase family
AS52_02149	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS52_02153	COG0733	neurotransmitter:sodium symporter activity
AS52_02154	COG3773	Cell wall hydrolase
AS52_02158	COG0673	inositol 2-dehydrogenase activity
AS52_02159	COG1082	Xylose isomerase domain protein TIM barrel
AS52_02160	COG2094	Belongs to the DNA glycosylase MPG family
AS52_02161	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS52_02163	COG0454	-acetyltransferase
AS52_02165	COG2814	Major facilitator Superfamily
AS52_02168	COG3871	stress protein (general stress protein 26)
AS52_02172	COG1595	DNA-templated transcription, initiation
AS52_02173	COG4873	Protein conserved in bacteria
AS52_02174	COG0714	Associated with various cellular activities
AS52_02175	COG4548	von Willebrand factor, type A
AS52_02176	COG0697	spore germination
AS52_02178	COG2207	Transcriptional regulator
AS52_02179	COG1994	Peptidase M50
AS52_02181	COG1119	ATPase activity
AS52_02184	COG1657	PFAM Prenyltransferase squalene oxidase
AS52_02186	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AS52_02186	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AS52_02190	COG1378	Sugar-specific transcriptional regulator TrmB
AS52_02192	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS52_02197	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_02198	COG1279	arginine transmembrane transporter activity
AS52_02199	COG1279	arginine transmembrane transporter activity
AS52_02212	COG1279	arginine transmembrane transporter activity
AS52_02216	COG2814	Major facilitator Superfamily
AS52_02218	COG3541	Predicted nucleotidyltransferase
AS52_02221	COG1396	sequence-specific DNA binding
AS52_02224	COG0494	nUDIX hydrolase
AS52_02225	COG1335	isochorismatase
AS52_02226	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AS52_02227	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AS52_02228	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AS52_02229	COG1098	S1 RNA binding domain
AS52_02230	COG1404	Belongs to the peptidase S8 family
AS52_02231	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_02232	COG1254	Belongs to the acylphosphatase family
AS52_02233	COG2223	nitrite transmembrane transporter activity
AS52_02234	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_02235	COG0463	Glycosyl transferase, family 2
AS52_02237	COG0662	Cupin 2, conserved barrel domain protein
AS52_02237	COG2207	Transcriptional regulator
AS52_02238	COG0697	spore germination
AS52_02239	COG0488	(ABC) transporter
AS52_02240	COG0697	spore germination
AS52_02241	COG0531	amino acid
AS52_02244	COG1131	(ABC) transporter
AS52_02245	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS52_02246	COG1757	Na H antiporter
AS52_02248	COG1609	Transcriptional regulator
AS52_02250	COG1533	DNA photolyase activity
AS52_02254	COG0551	DNA topoisomerase type I activity
AS52_02254	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS52_02256	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS52_02261	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_02265	COG1757	Na H antiporter
AS52_02266	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS52_02268	COG0697	spore germination
AS52_02270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_02272	COG5002	protein histidine kinase activity
AS52_02273	COG2204	response regulator
AS52_02275	COG4948	Mandelate Racemase Muconate Lactonizing
AS52_02276	COG1012	belongs to the aldehyde dehydrogenase family
AS52_02277	COG1027	Aspartate ammonia-lyase
AS52_02278	COG1012	belongs to the aldehyde dehydrogenase family
AS52_02280	COG1454	alcohol dehydrogenase
AS52_02281	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS52_02282	COG2720	vancomycin resistance protein
AS52_02290	COG0514	ATP-dependent DNA helicase (RecQ)
AS52_02296	COG1575	Belongs to the MenA family. Type 1 subfamily
AS52_02300	COG2814	Major facilitator Superfamily
AS52_02301	COG0583	DNA-binding transcription factor activity
AS52_02302	COG1725	Transcriptional regulator
AS52_02303	COG1131	(ABC) transporter
AS52_02305	COG1595	DNA-templated transcription, initiation
AS52_02308	COG1764	response to oxidative stress
AS52_02309	COG1846	Transcriptional regulator
AS52_02313	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
AS52_02315	COG3584	3D domain protein
AS52_02315	COG1388	LysM domain
AS52_02319	COG5002	protein histidine kinase activity
AS52_02320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS52_02321	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AS52_02322	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AS52_02325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS52_02328	COG2409	Drug exporters of the RND superfamily
AS52_02329	COG1834	amidinotransferase
AS52_02331	COG1295	ribonuclease BN
AS52_02342	COG0346	lactoylglutathione lyase activity
AS52_02344	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_02346	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS52_02348	COG2176	DNA-directed DNA polymerase activity
AS52_02351	COG0114	fumarate hydratase activity
AS52_02353	COG3757	hydrolase, family 25
AS52_02353	COG3409	Peptidoglycan-binding domain 1 protein
AS52_02355	COG5002	protein histidine kinase activity
AS52_02362	COG0778	Nitroreductase
AS52_02364	COG0300	oxidoreductase activity
AS52_02366	COG2610	gluconate transmembrane transporter activity
AS52_02367	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_02368	COG2195	Cleaves the N-terminal amino acid of tripeptides
AS52_02372	COG0583	DNA-binding transcription factor activity
AS52_02375	COG1301	dicarboxylic acid transport
AS52_02376	COG0019	diaminopimelate decarboxylase activity
AS52_02378	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS52_02380	COG4191	Histidine kinase
AS52_02383	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_02384	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_02386	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS52_02387	COG1024	Enoyl-CoA hydratase
AS52_02390	COG2045	Belongs to the ComB family
AS52_02391	COG1960	acyl-CoA dehydrogenase activity
AS52_02392	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_02393	COG1024	Enoyl-CoA hydratase
AS52_02396	COG1141	Ferredoxin
AS52_02398	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS52_02399	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS52_02400	COG0183	Belongs to the thiolase family
AS52_02401	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS52_02406	COG1509	lysine 2,3-aminomutase activity
AS52_02408	COG0833	amino acid
AS52_02409	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_02411	COG0456	acetyltransferase
AS52_02412	COG1979	alcohol dehydrogenase
AS52_02413	COG0738	Major facilitator superfamily
AS52_02416	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS52_02417	COG1181	Belongs to the D-alanine--D-alanine ligase family
AS52_02418	COG3773	Cell wall hydrolase
AS52_02420	COG3119	arylsulfatase activity
AS52_02421	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS52_02423	COG0531	amino acid
AS52_02424	COG2814	Major facilitator Superfamily
AS52_02425	COG1846	Transcriptional regulator
AS52_02426	COG2409	Drug exporters of the RND superfamily
AS52_02426	COG1033	growth of symbiont in host cell
AS52_02428	COG2202	Pas domain
AS52_02428	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_02429	COG3832	glyoxalase III activity
AS52_02430	COG0640	Transcriptional regulator
AS52_02433	COG2267	carboxylic ester hydrolase activity
AS52_02435	COG3386	PFAM SMP-30 Gluconolaconase
AS52_02437	COG2368	4-hydroxyphenylacetate
AS52_02438	COG3739	integral membrane protein
AS52_02440	COG0326	Molecular chaperone. Has ATPase activity
AS52_02441	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS52_02447	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS52_02448	COG3757	hydrolase, family 25
AS52_02448	COG3409	Peptidoglycan-binding domain 1 protein
AS52_02450	COG0697	spore germination
AS52_02451	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_02455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_02456	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AS52_02458	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS52_02467	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS52_02470	COG0494	nUDIX hydrolase
AS52_02471	COG0702	epimerase
AS52_02472	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_02473	COG1846	Transcriptional regulator
AS52_02474	COG2720	vancomycin resistance protein
AS52_02475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS52_02485	COG0076	glutamate decarboxylase activity
AS52_02490	COG2116	formate transmembrane transporter activity
AS52_02491	COG5609	conserved protein (DUF2294)
AS52_02494	COG2271	Major facilitator Superfamily
AS52_02495	COG0277	FAD linked oxidase domain protein
AS52_02497	COG0840	transmembrane signaling receptor activity
AS52_02499	COG0622	Phosphoesterase
AS52_02501	COG1408	metallophosphoesterase
AS52_02502	COG3663	DNA glycosylase
AS52_02503	COG3883	PFAM NLP P60 protein
AS52_02503	COG0791	NLP P60 protein
AS52_02504	COG1587	Uroporphyrinogen-III synthase
AS52_02505	COG1414	Transcriptional regulator
AS52_02506	COG0439	Biotin carboxylase
AS52_02507	COG0511	ligase activity, forming carbon-carbon bonds
AS52_02508	COG1984	allophanate hydrolase subunit 2
AS52_02509	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AS52_02510	COG4336	lyase activity
AS52_02511	COG1914	H( )-stimulated, divalent metal cation uptake system
AS52_02512	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AS52_02532	COG0772	Belongs to the SEDS family
AS52_02535	COG1595	DNA-templated transcription, initiation
AS52_02539	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_02540	COG1268	BioY protein
AS52_02541	COG0183	Belongs to the thiolase family
AS52_02545	COG0431	NADPH-dependent FMN reductase
AS52_02546	COG2197	response regulator
AS52_02547	COG2203	Gaf domain
AS52_02547	COG4585	Histidine kinase
AS52_02551	COG0697	spore germination
AS52_02553	COG2153	protein acetylation
AS52_02554	COG0129	dihydroxy-acid dehydratase activity
AS52_02555	COG2267	carboxylic ester hydrolase activity
AS52_02556	COG1227	inorganic diphosphatase activity
AS52_02560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AS52_02562	COG0204	Acyl-transferase
AS52_02563	COG2233	PERMEase
AS52_02566	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_02569	COG1914	H( )-stimulated, divalent metal cation uptake system
AS52_02573	COG1846	Transcriptional regulator
AS52_02575	COG4974	Belongs to the 'phage' integrase family
AS52_02578	COG0531	amino acid
AS52_02579	COG4302	ethanolamine ammonia-lyase activity
AS52_02580	COG4303	Ethanolamine ammonia lyase large subunit
AS52_02581	COG4819	ethanolamine utilization protein
AS52_02583	COG0833	amino acid
AS52_02585	COG1247	-acetyltransferase
AS52_02586	COG1335	isochorismatase
AS52_02588	COG3403	YqcI/YcgG family
AS52_02589	COG1280	lysine exporter protein (LysE YggA)
AS52_02590	COG2267	carboxylic ester hydrolase activity
AS52_02591	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AS52_02592	COG0187	DNA topoisomerase II activity
AS52_02593	COG1832	CoA-binding protein
AS52_02594	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AS52_02595	COG4841	protein insertion into membrane
AS52_02596	COG0824	Thioesterase
AS52_02602	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_02603	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AS52_02607	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AS52_02624	COG1183	phosphatidylcholine synthase activity
AS52_02627	COG2814	Major facilitator Superfamily
AS52_02628	COG1683	Conserved Protein
AS52_02629	COG1302	Protein conserved in bacteria
AS52_02632	COG1295	ribonuclease BN
AS52_02634	COG1115	amino acid carrier protein
AS52_02635	COG2814	Major facilitator Superfamily
AS52_02637	COG2814	Major facilitator Superfamily
AS52_02638	COG0789	Transcriptional regulator
AS52_02640	COG0288	reversible hydration of carbon dioxide
AS52_02641	COG0659	secondary active sulfate transmembrane transporter activity
AS52_02642	COG0745	RESPONSE REGULATOR receiver
AS52_02643	COG5002	protein histidine kinase activity
AS52_02645	COG4282	regulation of fungal-type cell wall biogenesis
AS52_02646	COG0531	amino acid
AS52_02648	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_02649	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AS52_02665	COG1363	Peptidase, m42
AS52_02667	COG1114	Component of the transport system for branched-chain amino acids
AS52_02670	COG0004	ammonium transporteR
AS52_02673	COG1252	NADH dehydrogenase
AS52_02674	COG0679	Auxin Efflux Carrier
AS52_02675	COG0281	malic enzyme
AS52_02676	COG1473	amidohydrolase
AS52_02677	COG2271	Major facilitator Superfamily
AS52_02681	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AS52_02682	COG0163	prenyltransferase activity
AS52_02683	COG0583	DNA-binding transcription factor activity
AS52_02684	COG0679	Auxin Efflux Carrier
AS52_02688	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_02689	COG0247	lactate metabolic process
AS52_02690	COG0277	FAD linked oxidase domain protein
AS52_02691	COG3835	regulator
AS52_02692	COG0693	protein deglycase activity
AS52_02694	COG2610	gluconate transmembrane transporter activity
AS52_02698	COG1131	(ABC) transporter
AS52_02700	COG2197	response regulator
AS52_02708	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_02710	COG0586	Pfam SNARE associated Golgi protein
AS52_02711	COG1515	deoxyribonuclease V activity
AS52_02712	COG0584	glycerophosphoryl diester phosphodiesterase
AS52_02713	COG3153	acetyltransferase
AS52_02713	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS52_02715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS52_02716	COG0531	amino acid
AS52_02747	COG5444	nuclease activity
AS52_02750	COG5444	nuclease activity
AS52_02752	COG5444	nuclease activity
AS52_02755	COG0534	Mate efflux family protein
AS52_02756	COG1566	PFAM secretion protein HlyD family protein
AS52_02758	COG1846	Transcriptional regulator
AS52_02759	COG0708	Exodeoxyribonuclease III
AS52_02762	COG0673	inositol 2-dehydrogenase activity
AS52_02763	COG1349	DNA-binding transcription factor activity
AS52_02764	COG3853	Toxic anion resistance protein (TelA)
AS52_02766	COG2310	stress, protein
AS52_02767	COG2310	stress, protein
AS52_02768	COG2310	stress, protein
AS52_02769	COG0737	Belongs to the 5'-nucleotidase family
AS52_02771	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS52_02772	COG1131	(ABC) transporter
AS52_02774	COG2084	Dehydrogenase
AS52_02775	COG1278	Cold shock
AS52_02776	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_02777	COG0028	Belongs to the TPP enzyme family
AS52_02778	COG1278	Cold shock
AS52_02784	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_02786	COG0427	acetyl-CoA hydrolase
AS52_02787	COG3279	Response regulator of the LytR AlgR family
AS52_02788	COG2323	membrane
AS52_02789	COG2814	Major facilitator Superfamily
AS52_02790	COG1388	LysM domain
AS52_02790	COG3584	3D domain protein
AS52_02791	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AS52_02796	COG3340	Belongs to the peptidase S51 family
AS52_02799	COG0277	FAD linked oxidase domain protein
AS52_02811	COG1486	melibiose metabolic process
AS52_02812	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS52_02813	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AS52_02817	COG0579	oxidoreductase
AS52_02856	COG5444	nuclease activity
AS52_02862	COG1486	melibiose metabolic process
AS52_02868	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS52_02872	COG0596	Alpha beta hydrolase
AS52_02873	COG1929	Belongs to the glycerate kinase type-1 family
AS52_02874	COG2610	gluconate transmembrane transporter activity
AS52_02875	COG3835	regulator
AS52_02876	COG1454	alcohol dehydrogenase
AS52_02877	COG3152	Membrane
AS52_02882	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS52_02883	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_02884	COG3152	Membrane
AS52_02885	COG3152	Membrane
AS52_02889	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS52_02891	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AS52_02894	COG2390	Transcriptional regulator
AS52_02899	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AS52_02901	COG1695	Transcriptional regulator
AS52_02902	COG0501	Belongs to the peptidase M48B family
AS52_02903	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_02904	COG1742	UPF0060 membrane protein
AS52_02906	COG2182	Extracellular solute-binding protein
AS52_02910	COG2031	fatty acid transporter
AS52_02915	COG2391	methyltransferase activity
AS52_02918	COG1979	alcohol dehydrogenase
AS52_02919	COG0583	DNA-binding transcription factor activity
AS52_02923	COG0456	acetyltransferase
AS52_02924	COG2211	Major facilitator Superfamily
AS52_02925	COG2211	Major facilitator Superfamily
AS52_02931	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_02932	COG1063	alcohol dehydrogenase
AS52_02937	COG0025	NhaP-type Na H and K H
AS52_02938	COG1253	flavin adenine dinucleotide binding
AS52_02940	COG4325	translation initiation factor activity
AS52_02942	COG4608	Belongs to the ABC transporter superfamily
AS52_02944	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS52_02945	COG0601	transmembrane transport
AS52_02946	COG0747	negative chemotaxis
AS52_02948	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_02952	COG0583	DNA-binding transcription factor activity
AS52_02953	COG0697	spore germination
AS52_02956	COG0579	oxidoreductase
AS52_02957	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AS52_02958	COG0561	phosphatase activity
AS52_02961	COG0668	transmembrane transport
AS52_02968	COG2309	aminopeptidase activity
AS52_02969	COG1414	Transcriptional regulator
AS52_02970	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS52_02971	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AS52_02972	COG0277	FAD linked oxidase domain protein
AS52_02973	COG0247	lactate metabolic process
AS52_02974	COG0277	FAD linked oxidase domain protein
AS52_02975	COG1620	l-lactate permease
AS52_02977	COG2271	Major facilitator Superfamily
AS52_02978	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS52_02980	COG1802	Transcriptional regulator
AS52_02984	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AS52_02985	COG1131	(ABC) transporter
AS52_02989	COG1595	DNA-templated transcription, initiation
AS52_02994	COG4682	membrane
AS52_02997	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_02998	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_02999	COG0598	Magnesium transport protein CorA
AS52_03000	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AS52_03002	COG2323	membrane
AS52_03003	COG1876	peptidase activity
AS52_03005	COG5002	protein histidine kinase activity
AS52_03006	COG0745	RESPONSE REGULATOR receiver
AS52_03010	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS52_03013	COG2814	Major facilitator Superfamily
AS52_03014	COG1764	response to oxidative stress
AS52_03016	COG2311	Membrane
AS52_03029	COG0559	Belongs to the binding-protein-dependent transport system permease family
AS52_03031	COG0347	Belongs to the P(II) protein family
AS52_03032	COG0004	ammonium transporteR
AS52_03033	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AS52_03036	COG0596	Alpha beta hydrolase
AS52_03039	COG0456	acetyltransferase
AS52_03039	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS52_03040	COG1960	acyl-CoA dehydrogenase activity
AS52_03048	COG4604	ABC transporter, ATP-binding protein
AS52_03049	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_03050	COG1492	cobalamin metabolic process
AS52_03053	COG0531	amino acid
AS52_03055	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_03056	COG2404	hydrolase activity, acting on ester bonds
AS52_03057	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AS52_03059	COG1609	Transcriptional regulator
AS52_03061	COG2271	Major facilitator Superfamily
AS52_03062	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS52_03065	COG1233	COG1233 Phytoene dehydrogenase and related
AS52_03066	COG1215	transferase activity, transferring glycosyl groups
AS52_03077	COG0831	urea catabolic process
AS52_03078	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS52_03079	COG1388	LysM domain
AS52_03079	COG0791	NLP P60 protein
AS52_03080	COG3584	3D domain protein
AS52_03080	COG1388	LysM domain
AS52_03081	COG0778	Nitroreductase
AS52_03082	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS52_03083	COG0586	Pfam SNARE associated Golgi protein
AS52_03085	COG0400	carboxylic ester hydrolase activity
AS52_03086	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS52_03087	COG2244	polysaccharide biosynthetic process
AS52_03088	COG0697	spore germination
AS52_03089	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_03093	COG1132	(ABC) transporter
AS52_03098	COG4195	phage-related replication protein
AS52_03101	COG0783	Belongs to the Dps family
AS52_03103	COG5577	PFAM Coat F domain
AS52_03104	COG1253	flavin adenine dinucleotide binding
AS52_03107	COG0517	IMP dehydrogenase activity
AS52_03107	COG0516	GMP reductase activity
AS52_03109	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS52_03109	COG0723	plastoquinol--plastocyanin reductase activity
AS52_03112	COG0287	Prephenate dehydrogenase
AS52_03114	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AS52_03114	COG1605	Chorismate mutase
AS52_03116	COG2059	Chromate
AS52_03117	COG2059	Chromate
AS52_03119	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AS52_03120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS52_03121	COG2508	Transcriptional regulator
AS52_03122	COG0011	TIGRFAM Protein of
AS52_03123	COG0791	NLP P60 protein
AS52_03123	COG1388	LysM domain
AS52_03124	COG0753	catalase activity
AS52_03127	COG0733	neurotransmitter:sodium symporter activity
AS52_03136	COG0730	response to heat
AS52_03137	COG1902	pentaerythritol trinitrate reductase activity
AS52_03140	COG2205	protein histidine kinase activity
AS52_03147	COG0640	Transcriptional regulator
AS52_03149	COG0778	Nitroreductase
AS52_03152	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS52_03153	COG4991	sh3 domain protein
AS52_03153	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_03153	COG3103	Sh3 type 3 domain protein
AS52_03154	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AS52_03155	COG2002	toxin-antitoxin pair type II binding
AS52_03156	COG2318	DinB family
AS52_03157	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AS52_03160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AS52_03161	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_03164	COG2211	Major facilitator Superfamily
AS52_03165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_03166	COG1597	lipid kinase activity
AS52_03168	COG0372	Belongs to the citrate synthase family
AS52_03169	COG0583	DNA-binding transcription factor activity
AS52_03172	COG2202	Pas domain
AS52_03172	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_03173	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_03179	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_03180	COG2261	transglycosylase associated protein
AS52_03183	COG0740	serine-type endopeptidase activity
AS52_03186	COG1027	Aspartate ammonia-lyase
AS52_03187	COG0252	asparaginase activity
AS52_03188	COG1396	sequence-specific DNA binding
AS52_03192	COG0640	Transcriptional regulator
AS52_03196	COG0531	amino acid
AS52_03197	COG1959	2 iron, 2 sulfur cluster binding
AS52_03201	COG0281	malic enzyme
AS52_03202	COG2746	aminoglycoside 3-N-acetyltransferase activity
AS52_03204	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_03205	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_03207	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS52_03208	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AS52_03211	COG0477	Major facilitator Superfamily
AS52_03212	COG1846	Transcriptional regulator
AS52_03213	COG0789	Transcriptional regulator
AS52_03214	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_03221	COG1819	glycosyl
AS52_03226	COG1902	pentaerythritol trinitrate reductase activity
AS52_03228	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS52_03231	COG2814	Major facilitator Superfamily
AS52_03233	COG1228	amidohydrolase
AS52_03235	COG1316	TRANSCRIPTIONal
AS52_03236	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_03240	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AS52_03242	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AS52_03243	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AS52_03254	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_03255	COG1280	lysine exporter protein (LysE YggA)
AS52_03256	COG0531	amino acid
AS52_03261	COG3764	Sortase (surface protein transpeptidase)
AS52_03262	COG0730	response to heat
AS52_03263	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_03264	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AS52_03266	COG2130	NADP-dependent
AS52_03272	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_03275	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AS52_03277	COG0501	Belongs to the peptidase M48B family
AS52_03285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AS52_03287	COG1309	transcriptional regulator
AS52_03288	COG2076	Multidrug Resistance protein
AS52_03289	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AS52_03290	COG1278	Cold shock
AS52_03291	COG2323	membrane
AS52_03294	COG2910	NAD(P)H-binding
AS52_03298	COG4607	ABC-type enterochelin transport system periplasmic component
AS52_03299	COG4604	ABC transporter, ATP-binding protein
AS52_03300	COG4605	iron ion homeostasis
AS52_03301	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_03302	COG3773	Cell wall hydrolase
AS52_03305	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS52_03306	COG0681	Belongs to the peptidase S26 family
AS52_03312	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AS52_03313	COG1396	sequence-specific DNA binding
AS52_03314	COG0861	Integral membrane protein TerC family
AS52_03315	COG1609	Transcriptional regulator
AS52_03316	COG1959	2 iron, 2 sulfur cluster binding
AS52_03330	COG3773	Cell wall hydrolase
AS52_03331	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AS52_03336	COG3546	catalase activity
AS52_03340	COG1280	lysine exporter protein (LysE YggA)
AS52_03341	COG1917	Cupin 2, conserved barrel domain protein
AS52_03341	COG2207	Transcriptional regulator
AS52_03342	COG4585	Histidine kinase
AS52_03346	COG3209	COG3209 Rhs family protein
AS52_03350	COG1819	glycosyl
AS52_03353	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AS52_03355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS52_03358	COG0346	lactoylglutathione lyase activity
AS52_03361	COG1136	(ABC) transporter
AS52_03362	COG0577	efflux transmembrane transporter activity
AS52_03363	COG5002	protein histidine kinase activity
AS52_03363	COG3850	Histidine kinase
AS52_03365	COG0384	phenazine biosynthesis protein PhzF
AS52_03368	COG5002	protein histidine kinase activity
AS52_03369	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_03375	COG4989	oxidoreductase activity
AS52_03377	COG0697	spore germination
AS52_03392	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AS52_03394	COG1301	dicarboxylic acid transport
AS52_03395	COG2824	Alkylphosphonate utilization operon protein PhnA
AS52_03401	COG0405	Gamma-glutamyltransferase
AS52_03402	COG1073	alpha beta
AS52_03405	COG0477	Major facilitator Superfamily
AS52_03406	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_03409	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_03411	COG1960	acyl-CoA dehydrogenase activity
AS52_03412	COG1063	alcohol dehydrogenase
AS52_03413	COG0745	RESPONSE REGULATOR receiver
AS52_03414	COG2205	protein histidine kinase activity
AS52_03415	COG1136	(ABC) transporter
AS52_03416	COG0577	efflux transmembrane transporter activity
AS52_03418	COG0412	Dienelactone hydrolase
AS52_03419	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_03423	COG0730	response to heat
AS52_03424	COG0425	Belongs to the sulfur carrier protein TusA family
AS52_03425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS52_03425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_03426	COG0425	Belongs to the sulfur carrier protein TusA family
AS52_03426	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS52_03429	COG2210	Belongs to the sulfur carrier protein TusA family
AS52_03430	COG0425	Belongs to the sulfur carrier protein TusA family
AS52_03431	COG1937	Protein conserved in bacteria
AS52_03439	COG2188	Transcriptional regulator
AS52_03440	COG2723	6-phospho-beta-galactosidase activity
AS52_03446	COG1280	lysine exporter protein (LysE YggA)
AS52_03449	COG0583	DNA-binding transcription factor activity
AS52_03452	COG0346	lactoylglutathione lyase activity
AS52_03454	COG3706	GGDEF domain
AS52_03455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AS52_03458	COG0778	Nitroreductase
AS52_03459	COG1012	belongs to the aldehyde dehydrogenase family
AS52_03462	COG1704	LemA family
AS52_03463	COG0726	polysaccharide deacetylase
AS52_03466	COG1733	regulation of RNA biosynthetic process
AS52_03467	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS52_03468	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS52_03469	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS52_03472	COG2304	oxidoreductase activity
AS52_03474	COG0346	lactoylglutathione lyase activity
AS52_03475	COG2808	Putative FMN-binding domain
AS52_03483	COG4807	Protein conserved in bacteria
AS52_03485	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AS52_03486	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_03487	COG1278	Cold shock
AS52_03489	COG1278	Cold shock
AS52_03491	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AS52_03492	COG1301	dicarboxylic acid transport
AS52_03493	COG2258	MOSC domain
AS52_03494	COG2807	transmembrane transport
AS52_03495	COG2186	Transcriptional regulator
AS52_03502	COG0659	secondary active sulfate transmembrane transporter activity
AS52_03504	COG0583	DNA-binding transcription factor activity
AS52_03505	COG1063	alcohol dehydrogenase
AS52_03509	COG1131	(ABC) transporter
AS52_03522	COG0561	phosphatase activity
AS52_03524	COG2312	Erythromycin esterase
AS52_03528	COG2329	Antibiotic biosynthesis monooxygenase
AS52_03531	COG5002	protein histidine kinase activity
AS52_03532	COG0745	RESPONSE REGULATOR receiver
AS52_03535	COG1131	(ABC) transporter
AS52_03539	COG0583	DNA-binding transcription factor activity
AS52_03540	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_03543	COG1064	alcohol dehydrogenase
AS52_03544	COG0789	Transcriptional regulator
AS52_03547	COG0662	Cupin 2, conserved barrel domain protein
AS52_03551	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_03552	COG1278	Cold shock
AS52_03555	COG3290	protein histidine kinase activity
AS52_03555	COG0840	transmembrane signaling receptor activity
AS52_03556	COG5001	Diguanylate cyclase
AS52_03557	COG1876	peptidase activity
AS52_03561	COG0598	Magnesium transport protein CorA
AS52_03562	COG1366	Belongs to the anti-sigma-factor antagonist family
AS52_03564	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_03569	COG4335	DNA alkylation repair
AS52_03570	COG0454	-acetyltransferase
AS52_03572	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS52_03574	COG2186	Transcriptional regulator
AS52_03578	COG3619	membrane
AS52_03580	COG1349	DNA-binding transcription factor activity
AS52_03581	COG0561	phosphatase activity
AS52_03583	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS52_03587	COG1280	lysine exporter protein (LysE YggA)
AS52_03595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AS52_03599	COG2160	L-arabinose isomerase activity
AS52_03602	COG1609	Transcriptional regulator
AS52_03603	COG1078	dGTPase activity
AS52_03604	COG1999	signal sequence binding
AS52_03606	COG1131	(ABC) transporter
AS52_03614	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS52_03615	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS52_03616	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AS52_03616	COG1918	ferrous iron import across plasma membrane
AS52_03622	COG1846	Transcriptional regulator
AS52_03628	COG0697	spore germination
AS52_03629	COG0583	DNA-binding transcription factor activity
AS52_03630	COG1012	belongs to the aldehyde dehydrogenase family
AS52_03631	COG1388	LysM domain
AS52_03631	COG0791	NLP P60 protein
AS52_03632	COG2258	MOSC domain
AS52_03634	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AS52_03642	COG5646	InterPro IPR014922
AS52_03643	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AS52_03659	COG1074	ATP-dependent DNA helicase activity
AS52_03670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS52_03680	COG1278	Cold shock
AS52_03681	COG2814	Major facilitator Superfamily
AS52_03683	COG0583	DNA-binding transcription factor activity
AS52_03685	COG2807	transmembrane transport
AS52_03688	COG0604	alcohol dehydrogenase
AS52_03690	COG1733	regulation of RNA biosynthetic process
AS52_03693	COG1388	LysM domain
AS52_03695	COG2271	Major facilitator Superfamily
AS52_03696	COG4948	Mandelate Racemase Muconate Lactonizing
AS52_03698	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS52_03699	COG1414	Transcriptional regulator
AS52_03703	COG1335	isochorismatase
AS52_03704	COG0693	protein deglycase activity
AS52_03707	COG0789	Transcriptional regulator
AS52_03707	COG4978	Transcriptional regulator
AS52_03710	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_03711	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS52_03712	COG1263	PTS System
AS52_03712	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_03712	COG2190	(PTS) system
AS52_03714	COG0523	cobalamin synthesis protein
AS52_03715	COG0717	Belongs to the dCTP deaminase family
AS52_03716	COG0523	cobalamin synthesis protein
AS52_03718	COG1012	belongs to the aldehyde dehydrogenase family
AS52_03721	COG1501	Belongs to the glycosyl hydrolase 31 family
AS52_03723	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS52_03724	COG2211	Major facilitator Superfamily
AS52_03727	COG2311	Membrane
AS52_03737	COG0047	phosphoribosylformylglycinamidine synthase activity
AS52_03738	COG1522	sequence-specific DNA binding
AS52_03742	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_03743	COG2267	carboxylic ester hydrolase activity
AS52_03745	COG1335	isochorismatase
AS52_03747	COG0346	lactoylglutathione lyase activity
AS52_03754	COG0477	Major facilitator Superfamily
AS52_03756	COG0477	Major facilitator Superfamily
AS52_03757	COG1309	transcriptional regulator
AS52_03759	COG4572	Cation transport regulator
AS52_03760	COG1621	beta-fructofuranosidase activity
AS52_03762	COG1609	Transcriptional regulator
AS52_03776	COG1266	CAAX protease self-immunity
AS52_03778	COG0156	8-amino-7-oxononanoate synthase activity
AS52_03781	COG1263	PTS System
AS52_03781	COG2190	(PTS) system
AS52_03781	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_03782	COG0252	asparaginase activity
AS52_03785	COG0686	Belongs to the AlaDH PNT family
AS52_03788	COG1695	Transcriptional regulator
AS52_03790	COG0671	phosphoesterase, PA-phosphatase related
AS52_03791	COG5002	protein histidine kinase activity
AS52_03792	COG0745	RESPONSE REGULATOR receiver
AS52_03793	COG0745	RESPONSE REGULATOR receiver
AS52_03796	COG0583	DNA-binding transcription factor activity
AS52_03798	COG2814	Major facilitator Superfamily
AS52_03799	COG0110	maltose O-acetyltransferase activity
AS52_03802	COG3620	sequence-specific DNA binding
AS52_03813	COG2801	Transposase and inactivated derivatives
AS52_03821	COG1971	Probably functions as a manganese efflux pump
AS52_03822	COG3339	Conserved Protein
AS52_03825	COG2207	Transcriptional regulator
AS52_03825	COG3708	Transcriptional regulator
AS52_03830	COG0303	'Molybdopterin
AS52_03832	COG0521	Mo-molybdopterin cofactor biosynthetic process
AS52_03833	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AS52_03843	COG2828	Protein conserved in bacteria
AS52_03844	COG0583	DNA-binding transcription factor activity
AS52_03845	COG2851	Citrate transporter
AS52_03850	COG0670	Belongs to the BI1 family
AS52_03854	COG0791	NLP P60 protein
AS52_03855	COG2814	Major facilitator Superfamily
AS52_03856	COG1846	Transcriptional regulator
AS52_03860	COG1278	Cold shock
AS52_03863	COG1113	amino acid transport
AS52_03864	COG1113	amino acid transport
AS52_03865	COG1012	belongs to the aldehyde dehydrogenase family
AS52_03866	COG0506	proline dehydrogenase activity
AS52_03867	COG3878	Protein conserved in bacteria
AS52_03871	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_03872	COG3300	MHYT domain
AS52_03872	COG5001	Diguanylate cyclase
AS52_03879	COG4640	response to antibiotic
AS52_03882	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AS52_03883	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AS52_03889	COG1247	-acetyltransferase
AS52_03893	COG0789	Transcriptional regulator
AS52_03894	COG0667	Aldo Keto reductase
AS52_03896	COG0789	Transcriptional regulator
AS52_03899	COG1621	beta-fructofuranosidase activity
AS52_03900	COG4980	gas vesicle protein
AS52_03905	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS52_03906	COG0577	efflux transmembrane transporter activity
AS52_03907	COG1136	(ABC) transporter
AS52_03909	COG0642	Histidine kinase
AS52_03910	COG0745	RESPONSE REGULATOR receiver
AS52_03912	COG1289	transmembrane transporter activity
AS52_03913	COG1937	Protein conserved in bacteria
AS52_03914	COG3209	COG3209 Rhs family protein
AS52_03917	COG3973	AAA domain
AS52_03919	COG1024	Enoyl-CoA hydratase
AS52_03920	COG1733	regulation of RNA biosynthetic process
AS52_03921	COG2124	cytochrome p450
AS52_03922	COG2259	Doxx family
AS52_03923	COG0463	Glycosyl transferase, family 2
AS52_03925	COG0463	Glycosyl transferase, family 2
AS52_03928	COG0791	NLP P60 protein
AS52_03928	COG1388	LysM domain
AS52_03929	COG0840	transmembrane signaling receptor activity
AS52_03930	COG1846	Transcriptional regulator
AS52_03932	COG1595	DNA-templated transcription, initiation
AS52_03933	COG0726	polysaccharide deacetylase
AS52_03934	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS52_03936	COG0697	spore germination
AS52_03939	COG0833	amino acid
AS52_03941	COG0405	Gamma-glutamyltransferase
AS52_03943	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS52_03944	COG0569	domain protein
AS52_03946	COG1522	sequence-specific DNA binding
AS52_03948	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS52_03949	COG0745	RESPONSE REGULATOR receiver
AS52_03950	COG2770	Histidine kinase
AS52_03950	COG2205	protein histidine kinase activity
AS52_03951	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AS52_03952	COG1607	acyl-coa hydrolase
AS52_03953	COG1802	Transcriptional regulator
AS52_03954	COG0697	spore germination
AS52_03956	COG0006	proline dipeptidase activity
AS52_03958	COG1316	TRANSCRIPTIONal
AS52_03960	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS52_03961	COG5522	Integral membrane protein (intg_mem_TP0381)
AS52_03962	COG1174	glycine betaine transport
AS52_03963	COG1125	glycine betaine transport
AS52_03963	COG0517	IMP dehydrogenase activity
AS52_03967	COG2814	Major facilitator Superfamily
AS52_03969	COG0395	ABC-type sugar transport system, permease component
AS52_03971	COG1653	transport
AS52_03974	COG2205	protein histidine kinase activity
AS52_03975	COG0730	response to heat
AS52_03976	COG1301	dicarboxylic acid transport
AS52_03983	COG1316	TRANSCRIPTIONal
AS52_03984	COG1368	sulfuric ester hydrolase activity
AS52_03986	COG0697	spore germination
AS52_03987	COG1902	pentaerythritol trinitrate reductase activity
AS52_03990	COG1113	amino acid transport
AS52_03991	COG5505	Protein of unknown function (DUF819)
AS52_03992	COG1309	transcriptional regulator
AS52_03994	COG0583	DNA-binding transcription factor activity
AS52_03995	COG0730	response to heat
AS52_03996	COG1247	-acetyltransferase
AS52_03997	COG2910	NAD(P)H-binding
AS52_03998	COG1285	pathogenesis
AS52_04000	COG4195	phage-related replication protein
AS52_04002	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS52_04005	COG1113	amino acid transport
AS52_04011	COG0463	Glycosyl transferase, family 2
AS52_04016	COG2514	catechol 2,3-dioxygenase activity
AS52_04020	COG1280	lysine exporter protein (LysE YggA)
AS52_04021	COG1115	amino acid carrier protein
AS52_04023	COG0385	Bile acid
AS52_04024	COG0668	transmembrane transport
AS52_04025	COG2340	Cysteine-rich secretory protein family
AS52_04026	COG1253	flavin adenine dinucleotide binding
AS52_04028	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AS52_04029	COG0589	response to stress
AS52_04031	COG0205	6-phosphofructokinase activity
AS52_04032	COG0791	NLP P60 protein
AS52_04032	COG1388	LysM domain
AS52_04036	COG0432	Pfam Uncharacterised protein family UPF0047
AS52_04037	COG0697	spore germination
AS52_04038	COG0814	amino acid
AS52_04043	COG1131	(ABC) transporter
AS52_04046	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AS52_04049	COG0584	glycerophosphoryl diester phosphodiesterase
AS52_04051	COG3842	ATPase activity
AS52_04056	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_04056	COG1263	PTS System
AS52_04057	COG3711	transcriptional antiterminator
AS52_04058	COG2190	(PTS) system
AS52_04059	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS52_04062	COG0772	Belongs to the SEDS family
AS52_04063	COG0659	secondary active sulfate transmembrane transporter activity
AS52_04064	COG0813	purine-nucleoside phosphorylase activity
AS52_04067	COG0671	phosphoesterase, PA-phosphatase related
AS52_04069	COG4326	sporulation control protein
AS52_04070	COG0515	serine threonine protein kinase
AS52_04074	COG4479	Belongs to the UPF0346 family
AS52_04075	COG3594	Acyltransferase
AS52_04078	COG1509	lysine 2,3-aminomutase activity
AS52_04079	COG0456	acetyltransferase
AS52_04080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS52_04081	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS52_04082	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS52_04083	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS52_04084	COG1301	dicarboxylic acid transport
AS52_04086	COG4191	Histidine kinase
AS52_04092	COG2755	lipolytic protein G-D-S-L family
AS52_04093	COG1999	signal sequence binding
AS52_04095	COG1307	EDD domain protein, DegV family
AS52_04097	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AS52_04099	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AS52_04100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AS52_04101	COG0788	formyltetrahydrofolate deformylase activity
AS52_04107	COG0076	glutamate decarboxylase activity
AS52_04111	COG0415	Belongs to the DNA photolyase family
AS52_04112	COG3852	Histidine kinase
AS52_04116	COG1012	belongs to the aldehyde dehydrogenase family
AS52_04118	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS52_04120	COG4846	Membrane protein involved in cytochrome C biogenesis
AS52_04121	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AS52_04122	COG0785	Cytochrome C biogenesis protein
AS52_04124	COG1132	(ABC) transporter
AS52_04125	COG1132	(ABC) transporter
AS52_04129	COG4224	UPF0291 protein
AS52_04130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AS52_04136	COG0463	Glycosyl transferase, family 2
AS52_04137	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AS52_04138	COG0531	amino acid
AS52_04141	COG0174	glutamine synthetase
AS52_04142	COG0789	Transcriptional regulator
AS52_04143	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AS52_04144	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AS52_04145	COG2860	membrane
AS52_04146	COG0464	growth
AS52_04148	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AS52_04150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AS52_04151	COG0531	amino acid
AS52_04153	COG4550	Control of competence regulator ComK, YlbF/YmcA
AS52_04154	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS52_04155	COG1013	pyruvate-flavodoxin oxidoreductase activity
AS52_04156	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AS52_04156	COG0674	pyruvate-flavodoxin oxidoreductase activity
AS52_04158	COG2359	stage V sporulation protein S
AS52_04159	COG1692	metallophosphoesterase
AS52_04161	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AS52_04162	COG1058	Belongs to the CinA family
AS52_04162	COG1546	Belongs to the CinA family
AS52_04163	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AS52_04164	COG1426	Protein conserved in bacteria
AS52_04167	COG0300	oxidoreductase activity
AS52_04168	COG0612	Peptidase, M16
AS52_04169	COG0612	Peptidase, M16
AS52_04174	COG2188	Transcriptional regulator
AS52_04175	COG1674	ftsk spoiiie
AS52_04175	COG4980	gas vesicle protein
AS52_04177	COG0740	serine-type endopeptidase activity
AS52_04178	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AS52_04180	COG0527	aspartate kinase activity
AS52_04181	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AS52_04182	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AS52_04183	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS52_04184	COG1873	PFAM PRC-barrel domain
AS52_04185	COG0612	Peptidase, M16
AS52_04186	COG0726	polysaccharide deacetylase
AS52_04187	COG1185	polyribonucleotide nucleotidyltransferase activity
AS52_04188	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AS52_04189	COG0196	riboflavin kinase activity
AS52_04192	COG1550	Protein conserved in bacteria
AS52_04194	COG1358	cellular component organization or biogenesis
AS52_04195	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AS52_04196	COG0195	Participates in both transcription termination and antitermination
AS52_04197	COG0779	Required for maturation of 30S ribosomal subunits
AS52_04198	COG2176	DNA-directed DNA polymerase activity
AS52_04199	COG0442	prolyl-tRNA aminoacylation
AS52_04200	COG0750	zinc metalloprotease
AS52_04202	COG4589	Belongs to the CDS family
AS52_04203	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AS52_04204	COG0233	cytoplasmic translational termination
AS52_04205	COG0528	UMP kinase activity
AS52_04206	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AS52_04209	COG1191	sigma factor activity
AS52_04210	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AS52_04211	COG0835	chemotaxis
AS52_04212	COG0643	Histidine kinase
AS52_04212	COG2198	Histidine kinase
AS52_04213	COG2201	protein-glutamate methylesterase activity
AS52_04214	COG0455	bacterial-type flagellum organization
AS52_04215	COG1419	protein localization to endoplasmic reticulum
AS52_04216	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AS52_04217	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AS52_04218	COG1684	flagellar biosynthetic protein fliR
AS52_04219	COG1987	bacterial-type flagellum assembly
AS52_04220	COG1338	Plays a role in the flagellum-specific transport system
AS52_04221	COG3190	flagellar
AS52_04222	COG2201	protein-glutamate methylesterase activity
AS52_04223	COG1776	CheC inhibitor of MCP methylation
AS52_04223	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS52_04224	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS52_04226	COG1582	Flagellar protein (FlbD)
AS52_04227	COG4786	Flagellar basal body rod
AS52_04228	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AS52_04231	COG2882	bacterial-type flagellum organization
AS52_04232	COG1157	protein secretion by the type III secretion system
AS52_04233	COG1317	bacterial-type flagellum organization
AS52_04234	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AS52_04235	COG1766	The M ring may be actively involved in energy transduction
AS52_04236	COG1677	Flagellar hook-basal body complex protein FliE
AS52_04237	COG1558	bacterial-type flagellum-dependent cell motility
AS52_04238	COG1815	bacterial-type flagellum-dependent cell motility
AS52_04239	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AS52_04240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AS52_04242	COG4974	Belongs to the 'phage' integrase family
AS52_04243	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AS52_04244	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AS52_04245	COG0758	DNA mediated transformation
AS52_04246	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AS52_04247	COG0045	succinate-CoA ligase (ADP-forming) activity
AS52_04251	COG0335	large ribosomal subunit rRNA binding
AS52_04253	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AS52_04255	COG1837	Belongs to the UPF0109 family
AS52_04256	COG0228	four-way junction DNA binding
AS52_04257	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AS52_04259	COG0552	protein localization to endoplasmic reticulum
AS52_04260	COG1196	nuclear chromosome segregation
AS52_04262	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS52_04263	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_04264	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AS52_04265	COG0416	fatty acid biosynthetic process
AS52_04266	COG1349	DNA-binding transcription factor activity
AS52_04267	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AS52_04268	COG1760	l-serine dehydratase
AS52_04269	COG1760	l-serine dehydratase
AS52_04271	COG1461	Dihydroxyacetone kinase
AS52_04272	COG1302	Protein conserved in bacteria
AS52_04273	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AS52_04274	COG1564	THIamine pyrophosphokinase
AS52_04275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AS52_04276	COG1162	GTPase activity
AS52_04277	COG2815	serine threonine protein kinase
AS52_04277	COG0515	serine threonine protein kinase
AS52_04278	COG0631	protein serine/threonine phosphatase activity
AS52_04280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AS52_04280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS52_04281	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AS52_04283	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AS52_04284	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AS52_04285	COG1758	RNA polymerase activity
AS52_04286	COG0194	GDP metabolic process
AS52_04287	COG2052	Domain of unknown function (DUF370)
AS52_04288	COG1561	YicC-like family, N-terminal region
AS52_04289	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AS52_04291	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AS52_04294	COG0543	2 iron, 2 sulfur cluster binding
AS52_04297	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AS52_04300	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AS52_04301	COG0564	pseudouridine synthase activity
AS52_04302	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AS52_04305	COG3599	regulation of cell shape
AS52_04306	COG2302	S4 RNA-binding domain
AS52_04307	COG0762	integral membrane protein
AS52_04308	COG1799	cell septum assembly
AS52_04309	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AS52_04311	COG1873	PFAM PRC-barrel domain
AS52_04312	COG1191	sigma factor activity
AS52_04313	COG1191	sigma factor activity
AS52_04315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AS52_04316	COG0849	cell division
AS52_04317	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AS52_04318	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AS52_04319	COG0772	Belongs to the SEDS family
AS52_04320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AS52_04321	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS52_04323	COG0768	penicillin binding
AS52_04325	COG4839	cell division protein FtsL
AS52_04327	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AS52_04329	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AS52_04330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS52_04331	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AS52_04332	COG0439	Biotin carboxylase
AS52_04333	COG0454	-acetyltransferase
AS52_04335	COG1024	Enoyl-CoA hydratase
AS52_04336	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AS52_04337	COG1399	metal-binding, possibly nucleic acid-binding protein
AS52_04338	COG1323	Belongs to the UPF0348 family
AS52_04339	COG3480	Lon protease (S16) C-terminal proteolytic domain
AS52_04340	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS52_04341	COG3314	Sporulation integral membrane protein YlbJ
AS52_04342	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AS52_04343	COG0742	ribosomal rna small subunit methyltransferase
AS52_04345	COG4471	UPF0298 protein
AS52_04347	COG3679	Belongs to the UPF0342 family
AS52_04351	COG4347	Protein of unknown function (DUF1405)
AS52_04353	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AS52_04356	COG5582	Belongs to the UPF0302 family
AS52_04357	COG0457	Tetratricopeptide repeat
AS52_04358	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AS52_04359	COG0287	Prephenate dehydrogenase
AS52_04360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AS52_04361	COG0159	tryptophan synthase activity
AS52_04363	COG0134	indole-3-glycerol-phosphate synthase activity
AS52_04364	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS52_04366	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AS52_04367	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AS52_04368	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AS52_04369	COG0105	UTP biosynthetic process
AS52_04370	COG0142	geranyltranstransferase activity
AS52_04371	COG2226	methyltransferase
AS52_04372	COG0142	geranyltranstransferase activity
AS52_04374	COG0302	gtp cyclohydrolase
AS52_04375	COG0776	regulation of translation
AS52_04376	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AS52_04383	COG2271	Major facilitator Superfamily
AS52_04384	COG1304	FMN binding
AS52_04385	COG0539	negative regulation of cytoplasmic translation
AS52_04387	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AS52_04390	COG2959	enzyme of heme biosynthesis
AS52_04391	COG3409	Peptidoglycan-binding domain 1 protein
AS52_04391	COG3773	Cell wall hydrolase
AS52_04392	COG2339	peptidase activity
AS52_04393	COG0252	asparaginase activity
AS52_04394	COG0492	ferredoxin-NADP+ reductase activity
AS52_04395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS52_04396	COG4862	establishment of competence for transformation
AS52_04397	COG0789	Transcriptional regulator
AS52_04398	COG1408	metallophosphoesterase
AS52_04401	COG1266	CAAX protease self-immunity
AS52_04402	COG0514	ATP-dependent DNA helicase (RecQ)
AS52_04404	COG1141	Ferredoxin
AS52_04405	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AS52_04406	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS52_04407	COG0739	heme binding
AS52_04408	COG5002	protein histidine kinase activity
AS52_04409	COG0745	RESPONSE REGULATOR receiver
AS52_04410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS52_04411	COG1333	cytochrome c biogenesis protein
AS52_04412	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_04413	COG1187	pseudouridine synthase activity
AS52_04414	COG0700	Nucleoside recognition
AS52_04415	COG2715	membrane protein required for spore maturation
AS52_04416	COG1686	Belongs to the peptidase S11 family
AS52_04417	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AS52_04418	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AS52_04419	COG1547	Domain of unknown function (DUF309)
AS52_04421	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AS52_04422	COG4086	secreted protein
AS52_04424	COG0697	spore germination
AS52_04427	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AS52_04434	COG1686	Belongs to the peptidase S11 family
AS52_04437	COG4974	Belongs to the 'phage' integrase family
AS52_04439	COG0735	belongs to the Fur family
AS52_04440	COG1300	Membrane
AS52_04441	COG0494	nUDIX hydrolase
AS52_04443	COG0667	Aldo Keto reductase
AS52_04446	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS52_04448	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS52_04449	COG1073	alpha beta
AS52_04452	COG0300	oxidoreductase activity
AS52_04453	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_04454	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS52_04455	COG1902	pentaerythritol trinitrate reductase activity
AS52_04457	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS52_04458	COG1012	belongs to the aldehyde dehydrogenase family
AS52_04459	COG2508	Transcriptional regulator
AS52_04463	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AS52_04463	COG0167	dihydroorotate dehydrogenase activity
AS52_04464	COG0493	'glutamate synthase
AS52_04465	COG2195	Cleaves the N-terminal amino acid of tripeptides
AS52_04466	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS52_04469	COG1376	ErfK ybiS ycfS ynhG family protein
AS52_04470	COG4129	membrane
AS52_04471	COG1126	abc transporter atp-binding protein
AS52_04472	COG0765	amino acid transport
AS52_04473	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS52_04475	COG1703	isobutyryl-CoA mutase activity
AS52_04476	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AS52_04476	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AS52_04478	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS52_04479	COG0022	dehydrogenase e1 component
AS52_04480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS52_04481	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS52_04484	COG0280	phosphate acetyltransferase
AS52_04485	COG3290	protein histidine kinase activity
AS52_04485	COG3829	transcription factor binding
AS52_04487	COG0584	glycerophosphoryl diester phosphodiesterase
AS52_04488	COG3093	addiction module antidote protein HigA
AS52_04489	COG3104	oligopeptide transport
AS52_04490	COG0745	RESPONSE REGULATOR receiver
AS52_04491	COG0750	zinc metalloprotease
AS52_04492	COG0497	DNA recombination
AS52_04494	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AS52_04497	COG1722	exodeoxyribonuclease VII activity
AS52_04499	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS52_04500	COG1302	Protein conserved in bacteria
AS52_04501	COG0439	Biotin carboxylase
AS52_04502	COG0511	ligase activity, forming carbon-carbon bonds
AS52_04510	COG3854	ATPases associated with a variety of cellular activities
AS52_04512	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AS52_04513	COG0006	proline dipeptidase activity
AS52_04514	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AS52_04516	COG3872	metal-dependent enzyme
AS52_04518	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS52_04519	COG1321	iron dependent repressor
AS52_04520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS52_04521	COG0095	Lipoate-protein ligase
AS52_04522	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS52_04524	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AS52_04525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AS52_04526	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS52_04532	COG4970	Tfp pilus assembly protein FimT
AS52_04533	COG4537	Required for transformation and DNA binding
AS52_04534	COG1459	type II secretion system
AS52_04535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AS52_04536	COG1393	Belongs to the ArsC family
AS52_04538	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_04540	COG2866	Carboxypeptidase
AS52_04541	COG1940	carbohydrate kinase activity
AS52_04542	COG4483	Protein conserved in bacteria
AS52_04543	COG0705	Rhomboid family
AS52_04543	COG0457	Tetratricopeptide repeat
AS52_04546	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AS52_04548	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AS52_04551	COG0704	Plays a role in the regulation of phosphate uptake
AS52_04554	COG0477	Major facilitator Superfamily
AS52_04561	COG2839	Protein conserved in bacteria
AS52_04563	COG2814	Major facilitator Superfamily
AS52_04564	COG1388	LysM domain
AS52_04565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AS52_04566	COG4709	membrane
AS52_04567	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AS52_04568	COG0735	belongs to the Fur family
AS52_04569	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS52_04570	COG1121	(ABC) transporter
AS52_04572	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AS52_04573	COG0513	Belongs to the DEAD box helicase family
AS52_04575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AS52_04576	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS52_04577	COG2384	SAM-dependent methyltransferase
AS52_04578	COG2010	Cytochrome c
AS52_04579	COG1960	acyl-CoA dehydrogenase activity
AS52_04580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AS52_04581	COG0358	DNA primase activity
AS52_04582	COG1671	Belongs to the UPF0178 family
AS52_04583	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AS52_04584	COG0517	IMP dehydrogenase activity
AS52_04587	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AS52_04588	COG0295	cytidine deaminase activity
AS52_04589	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AS52_04591	COG1480	7TM receptor with intracellular HD hydrolase
AS52_04592	COG1702	phosphate starvation-inducible protein PhoH
AS52_04597	COG1030	water channel activity
AS52_04598	COG1610	YqeY-like protein
AS52_04599	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AS52_04600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS52_04601	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AS52_04602	COG2264	protein methyltransferase activity
AS52_04605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AS52_04606	COG1420	regulation of RNA biosynthetic process
AS52_04607	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS52_04608	COG0481	GTPase activity
AS52_04610	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AS52_04611	COG0268	Binds directly to 16S ribosomal RNA
AS52_04612	COG1466	dna polymerase III delta subunit
AS52_04614	COG2333	competence protein COMEC
AS52_04614	COG0658	competence protein
AS52_04615	COG2131	deaminase
AS52_04616	COG1555	photosystem II stabilization
AS52_04616	COG1596	polysaccharide export
AS52_04617	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AS52_04618	COG2226	methyltransferase
AS52_04619	COG0799	negative regulation of ribosome biogenesis
AS52_04620	COG1713	HD superfamily hydrolase involved in NAD metabolism
AS52_04621	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AS52_04622	COG1534	Rna-binding protein
AS52_04623	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AS52_04624	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AS52_04625	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AS52_04627	COG0688	phosphatidylethanolamine metabolic process
AS52_04628	COG1183	phosphatidylcholine synthase activity
AS52_04630	COG1191	sigma factor activity
AS52_04633	COG0626	cystathionine gamma-synthase activity
AS52_04634	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS52_04635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AS52_04636	COG2226	methyltransferase
AS52_04639	COG0768	penicillin binding
AS52_04640	COG1335	isochorismatase
AS52_04641	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AS52_04642	COG0572	uridine kinase
AS52_04646	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AS52_04647	COG3906	Belongs to the UPF0473 family
AS52_04649	COG4472	Bacterial protein of unknown function (DUF965)
AS52_04651	COG0628	permease
AS52_04654	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS52_04656	COG0482	sulfurtransferase activity
AS52_04657	COG1104	cysteine desulfurase activity
AS52_04658	COG1959	2 iron, 2 sulfur cluster binding
AS52_04659	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AS52_04660	COG0581	inorganic phosphate transmembrane transporter activity
AS52_04661	COG0573	inorganic phosphate transmembrane transporter activity
AS52_04662	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AS52_04663	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AS52_04665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AS52_04666	COG0124	histidyl-tRNA synthetase
AS52_04668	COG0860	N-Acetylmuramoyl-L-alanine amidase
AS52_04669	COG1490	D-aminoacyl-tRNA deacylase activity
AS52_04670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS52_04671	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS52_04672	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AS52_04672	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AS52_04673	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS52_04673	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AS52_04675	COG2244	polysaccharide biosynthetic process
AS52_04676	COG2323	membrane
AS52_04678	COG1862	Preprotein translocase
AS52_04680	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AS52_04682	COG2255	four-way junction helicase activity
AS52_04688	COG1388	LysM domain
AS52_04689	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AS52_04690	COG0157	Belongs to the NadC ModD family
AS52_04691	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AS52_04692	COG1104	cysteine desulfurase activity
AS52_04693	COG1827	regulation of RNA biosynthetic process
AS52_04694	COG0077	Prephenate dehydratase
AS52_04695	COG4492	Belongs to the UPF0735 family
AS52_04696	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AS52_04697	COG3290	protein histidine kinase activity
AS52_04699	COG2868	ribosomal protein
AS52_04701	COG1530	ribonuclease E activity
AS52_04702	COG1994	Peptidase M50
AS52_04703	COG0739	heme binding
AS52_04704	COG2894	cell division
AS52_04705	COG0850	regulation of cytokinetic process
AS52_04706	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AS52_04707	COG1792	Involved in formation and maintenance of cell shape
AS52_04708	COG1077	Cell shape determining protein MreB Mrl
AS52_04709	COG2003	Belongs to the UPF0758 family
AS52_04710	COG0424	maF-like protein
AS52_04712	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AS52_04714	COG2322	membrane
AS52_04715	COG0285	dihydrofolate synthase activity
AS52_04716	COG0525	valine-tRNA ligase activity
AS52_04717	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS52_04718	COG1388	LysM domain
AS52_04719	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AS52_04720	COG0113	porphobilinogen synthase activity
AS52_04721	COG1587	Uroporphyrinogen-III synthase
AS52_04722	COG0181	hydroxymethylbilane synthase activity
AS52_04723	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AS52_04726	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AS52_04727	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AS52_04728	COG1067	ATP-dependent peptidase activity
AS52_04728	COG0470	DNA polymerase III
AS52_04729	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AS52_04730	COG0544	peptidyl-prolyl cis-trans isomerase activity
AS52_04731	COG0457	Tetratricopeptide repeat
AS52_04731	COG1477	protein flavinylation
AS52_04732	COG0066	3-isopropylmalate dehydratase activity
AS52_04733	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AS52_04735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS52_04736	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AS52_04737	COG0440	acetolactate synthase activity
AS52_04738	COG0028	Belongs to the TPP enzyme family
AS52_04740	COG0622	Phosphoesterase
AS52_04743	COG5401	PFAM Sporulation and spore germination
AS52_04744	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AS52_04745	COG1846	Transcriptional regulator
AS52_04747	COG0306	phosphate transporter
AS52_04748	COG1392	Phosphate transport regulator
AS52_04749	COG0768	penicillin binding
AS52_04751	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS52_04752	COG0431	NADPH-dependent FMN reductase
AS52_04753	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS52_04754	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS52_04755	COG1116	anion transmembrane transporter activity
AS52_04756	COG0475	glutathione-regulated potassium exporter activity
AS52_04757	COG0490	domain, Protein
AS52_04759	COG2197	response regulator
AS52_04760	COG0824	Thioesterase
AS52_04761	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AS52_04762	COG1053	succinate dehydrogenase
AS52_04763	COG2009	succinate dehydrogenase
AS52_04764	COG1719	4-vinyl reductase, 4VR
AS52_04765	COG0527	aspartate kinase activity
AS52_04767	COG3118	belongs to the thioredoxin family
AS52_04768	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AS52_04769	COG2086	electron transfer activity
AS52_04770	COG1024	Enoyl-CoA hydratase
AS52_04771	COG1309	transcriptional regulator
AS52_04772	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_04773	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AS52_04774	COG3766	membrane
AS52_04775	COG1193	negative regulation of DNA recombination
AS52_04776	COG1796	DNA polymerase
AS52_04776	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AS52_04777	COG1286	toxin biosynthetic process
AS52_04778	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AS52_04780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS52_04780	COG0072	phenylalanine-tRNA ligase activity
AS52_04782	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS52_04784	COG1363	Peptidase, m42
AS52_04788	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AS52_04789	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AS52_04790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AS52_04791	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AS52_04793	COG1484	DNA-dependent DNA replication
AS52_04794	COG3611	Membrane attachment protein
AS52_04795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AS52_04797	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AS52_04798	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS52_04801	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AS52_04802	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS52_04802	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AS52_04803	COG5002	protein histidine kinase activity
AS52_04804	COG0745	RESPONSE REGULATOR receiver
AS52_04806	COG0039	L-malate dehydrogenase activity
AS52_04807	COG0538	isocitrate dehydrogenase activity
AS52_04808	COG0372	Belongs to the citrate synthase family
AS52_04809	COG2707	UPF0756 membrane protein
AS52_04810	COG0628	permease
AS52_04811	COG3030	protein affecting phage T7 exclusion by the F plasmid
AS52_04813	COG0825	malonyl-CoA metabolic process
AS52_04814	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AS52_04815	COG2186	Transcriptional regulator
AS52_04816	COG0281	malic enzyme
AS52_04817	COG0587	DNA-directed DNA polymerase activity
AS52_04820	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AS52_04822	COG4109	DRTGG domain
AS52_04824	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AS52_04827	COG0165	Argininosuccinate lyase
AS52_04828	COG0137	argininosuccinate synthase activity
AS52_04831	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AS52_04832	COG0827	DNA restriction-modification system
AS52_04833	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AS52_04834	COG3874	Sporulation protein YtfJ
AS52_04836	COG1714	RDD family
AS52_04837	COG0616	signal peptide processing
AS52_04838	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AS52_04839	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AS52_04841	COG0301	tRNA thio-modification
AS52_04842	COG1104	cysteine desulfurase activity
AS52_04843	COG1114	Component of the transport system for branched-chain amino acids
AS52_04844	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AS52_04845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AS52_04846	COG1309	transcriptional regulator
AS52_04847	COG1956	GAF domain-containing protein
AS52_04849	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AS52_04850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS52_04851	COG0454	-acetyltransferase
AS52_04852	COG0517	IMP dehydrogenase activity
AS52_04853	COG0123	including yeast histone deacetylase and acetoin utilization protein
AS52_04857	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AS52_04857	COG1605	Chorismate mutase
AS52_04858	COG3118	belongs to the thioredoxin family
AS52_04859	COG4980	gas vesicle protein
AS52_04862	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AS52_04864	COG1674	ftsk spoiiie
AS52_04865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS52_04866	COG4848	Belongs to the UPF0354 family
AS52_04867	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_04868	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AS52_04869	COG1363	Peptidase, m42
AS52_04870	COG5584	Small secreted protein
AS52_04871	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS52_04872	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AS52_04874	COG0510	thiamine kinase activity
AS52_04875	COG1523	belongs to the glycosyl hydrolase 13 family
AS52_04877	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AS52_04878	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS52_04879	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AS52_04880	COG1349	DNA-binding transcription factor activity
AS52_04881	COG1187	pseudouridine synthase activity
AS52_04882	COG2244	polysaccharide biosynthetic process
AS52_04883	COG2081	HI0933 family
AS52_04885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS52_04886	COG0495	leucyl-tRNA aminoacylation
AS52_04887	COG2610	gluconate transmembrane transporter activity
AS52_04888	COG2814	Major facilitator Superfamily
AS52_04891	COG1242	4 iron, 4 sulfur cluster binding
AS52_04892	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AS52_04894	COG2267	carboxylic ester hydrolase activity
AS52_04895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AS52_04897	COG0671	phosphoesterase, PA-phosphatase related
AS52_04898	COG0438	transferase activity, transferring glycosyl groups
AS52_04898	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS52_04899	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AS52_04900	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AS52_04902	COG1506	peptidase
AS52_04903	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS52_04904	COG1116	anion transmembrane transporter activity
AS52_04905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS52_04906	COG0494	nUDIX hydrolase
AS52_04908	COG4824	toxin secretion phage lysis holin
AS52_04909	COG0783	Belongs to the Dps family
AS52_04911	COG0288	reversible hydration of carbon dioxide
AS52_04912	COG0523	cobalamin synthesis protein
AS52_04914	COG0254	rRNA binding
AS52_04915	COG1271	oxidase subunit
AS52_04916	COG1294	oxidase, subunit
AS52_04917	COG0716	FMN binding
AS52_04921	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS52_04922	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS52_04923	COG4948	Mandelate Racemase Muconate Lactonizing
AS52_04924	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_04925	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AS52_04926	COG0596	Alpha beta hydrolase
AS52_04927	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AS52_04928	COG1169	isochorismate synthase
AS52_04930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AS52_04932	COG0058	SHG alpha-glucan phosphorylase activity
AS52_04933	COG0297	glycogen (starch) synthase activity
AS52_04934	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AS52_04960	COG0318	PFAM AMP-dependent synthetase and ligase
AS52_04961	COG1285	pathogenesis
AS52_04965	COG0529	Catalyzes the synthesis of activated sulfate
AS52_04967	COG0306	phosphate transporter
AS52_04969	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AS52_04970	COG0346	lactoylglutathione lyase activity
AS52_04971	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS52_04973	COG0166	Belongs to the GPI family
AS52_04975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS52_04975	COG2111	Na H antiporter
AS52_04976	COG2111	Na H antiporter
AS52_04977	COG1006	Multisubunit Na H antiporter MnhC subunit
AS52_04978	COG0651	ATP synthesis coupled electron transport
AS52_04979	COG1863	multisubunit Na H antiporter MnhE subunit
AS52_04980	COG2212	antiporter activity
AS52_04981	COG1320	monovalent cation:proton antiporter activity
AS52_04982	COG1979	alcohol dehydrogenase
AS52_04983	COG2155	Conserved Protein
AS52_04984	COG1098	S1 RNA binding domain
AS52_04985	COG0436	Aminotransferase
AS52_04986	COG1522	sequence-specific DNA binding
AS52_04987	COG2267	carboxylic ester hydrolase activity
AS52_04988	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AS52_04989	COG2032	superoxide dismutase activity
AS52_04992	COG5018	Exonuclease
AS52_04993	COG2050	protein possibly involved in aromatic compounds catabolism
AS52_04995	COG1418	mRNA catabolic process
AS52_04997	COG2056	Na+-H+ antiporter family
AS52_04998	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AS52_04999	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AS52_05000	COG3584	3D domain protein
AS52_05002	COG1252	NADH dehydrogenase
AS52_05003	COG0492	ferredoxin-NADP+ reductase activity
AS52_05005	COG0316	Belongs to the HesB IscA family
AS52_05006	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AS52_05007	COG4844	belongs to the
AS52_05008	COG1252	NADH dehydrogenase
AS52_05009	COG4837	Protein of unknown function (DUF1462)
AS52_05010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AS52_05011	COG0083	homoserine kinase activity
AS52_05012	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AS52_05013	COG0460	homoserine dehydrogenase
AS52_05014	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS52_05015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS52_05016	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AS52_05017	COG0647	UMP catabolic process
AS52_05018	COG2445	Protein of unknown function DUF86
AS52_05020	COG4470	Protein conserved in bacteria
AS52_05022	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AS52_05023	COG0739	heme binding
AS52_05025	COG0733	neurotransmitter:sodium symporter activity
AS52_05027	COG3377	Domain of unknown function (DUF1805)
AS52_05028	COG1801	Protein of unknown function DUF72
AS52_05029	COG0719	Fe-S assembly protein
AS52_05030	COG0822	iron-sulfur transferase activity
AS52_05031	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AS52_05032	COG0719	Fe-S assembly protein
AS52_05033	COG0396	ATPase activity
AS52_05034	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS52_05035	COG1464	Belongs to the NlpA lipoprotein family
AS52_05036	COG2011	ABC-type metal ion transport system permease component
AS52_05037	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS52_05038	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS52_05039	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AS52_05041	COG0509	glycine decarboxylation via glycine cleavage system
AS52_05042	COG1393	Belongs to the ArsC family
AS52_05043	COG1960	acyl-CoA dehydrogenase activity
AS52_05044	COG0183	Belongs to the thiolase family
AS52_05045	COG1024	Enoyl-CoA hydratase
AS52_05045	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS52_05050	COG1120	ATPase activity
AS52_05051	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_05052	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS52_05053	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AS52_05056	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS52_05057	COG1309	transcriptional regulator
AS52_05059	COG1028	Short-chain dehydrogenase reductase Sdr
AS52_05060	COG0477	Major facilitator Superfamily
AS52_05061	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS52_05062	COG0583	DNA-binding transcription factor activity
AS52_05064	COG0672	)-iron permease
AS52_05065	COG3850	Histidine kinase
AS52_05065	COG5002	protein histidine kinase activity
AS52_05066	COG0745	RESPONSE REGULATOR receiver
AS52_05067	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AS52_05068	COG0671	phosphoesterase, PA-phosphatase related
AS52_05069	COG1846	Transcriptional regulator
AS52_05070	COG0778	Nitroreductase
AS52_05071	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AS52_05072	COG0314	molybdopterin synthase activity
AS52_05073	COG1763	Mo-molybdopterin cofactor biosynthetic process
AS52_05074	COG0303	'Molybdopterin
AS52_05075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS52_05076	COG0746	molybdenum cofactor guanylyltransferase activity
AS52_05078	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS52_05079	COG5609	conserved protein (DUF2294)
AS52_05080	COG3383	formate dehydrogenase (NAD+) activity
AS52_05081	COG2427	Protein of unknown function (DUF1641)
AS52_05082	COG0725	ABC transporter, periplasmic molybdate-binding protein
AS52_05083	COG4149	molybdate abc transporter
AS52_05085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AS52_05086	COG0557	exoribonuclease II activity
AS52_05087	COG1647	Serine aminopeptidase, S33
AS52_05088	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS52_05096	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AS52_05100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS52_05102	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AS52_05103	COG1660	Displays ATPase and GTPase activities
AS52_05104	COG1051	belongs to the nudix hydrolase family
AS52_05105	COG0492	ferredoxin-NADP+ reductase activity
AS52_05106	COG0457	Tetratricopeptide repeat
AS52_05107	COG0140	phosphoribosyl-ATP diphosphatase activity
AS52_05107	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AS52_05108	COG0107	imidazoleglycerol-phosphate synthase activity
AS52_05109	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AS52_05110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AS52_05111	COG0131	Imidazoleglycerol-phosphate dehydratase
AS52_05112	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AS52_05113	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AS52_05114	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AS52_05115	COG0110	maltose O-acetyltransferase activity
AS52_05116	COG0546	phosphoglycolate phosphatase activity
AS52_05117	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AS52_05118	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AS52_05119	COG1950	PFAM Membrane protein of
AS52_05121	COG3595	metallopeptidase activity
AS52_05123	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AS52_05124	COG0556	nucleotide-excision repair
AS52_05125	COG2204	response regulator
AS52_05126	COG0506	proline dehydrogenase activity
AS52_05127	COG4897	Protein conserved in bacteria
AS52_05128	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS52_05129	COG0793	Belongs to the peptidase S41A family
AS52_05129	COG3409	Peptidoglycan-binding domain 1 protein
AS52_05130	COG0739	heme binding
AS52_05131	COG2177	Part of the ABC transporter FtsEX involved in
AS52_05132	COG2884	Cell division ATP-binding protein ftsE
AS52_05133	COG0655	NAD(P)H dehydrogenase (quinone) activity
AS52_05135	COG0805	protein transport
AS52_05136	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS52_05137	COG3540	Alkaline phosphatase
AS52_05138	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AS52_05139	COG0653	protein targeting
AS52_05141	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AS52_05143	COG1516	flagellar protein fliS
AS52_05144	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AS52_05146	COG1113	amino acid transport
AS52_05149	COG1454	alcohol dehydrogenase
AS52_05150	COG1510	regulation of RNA biosynthetic process
AS52_05151	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AS52_05152	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AS52_05153	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AS52_05154	COG1256	bacterial-type flagellum assembly
AS52_05154	COG4786	Flagellar basal body rod
AS52_05158	COG1040	competence protein
AS52_05159	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AS52_05160	COG1307	EDD domain protein, DegV family
AS52_05161	COG1728	Protein conserved in bacteria
AS52_05163	COG2197	response regulator
AS52_05164	COG4585	Histidine kinase
AS52_05165	COG1739	Uncharacterized protein family UPF0029
AS52_05166	COG1316	TRANSCRIPTIONal
AS52_05167	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS52_05168	COG1585	Membrane protein implicated in regulation of membrane protease activity
AS52_05169	COG2268	Band 7 protein
AS52_05172	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS52_05174	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS52_05175	COG1388	LysM domain
AS52_05175	COG0791	NLP P60 protein
AS52_05176	COG0629	single-stranded DNA binding
AS52_05181	COG4786	Flagellar basal body rod
AS52_05182	COG4786	Flagellar basal body rod
AS52_05183	COG1077	Cell shape determining protein MreB Mrl
AS52_05184	COG1609	Transcriptional regulator
AS52_05185	COG0739	heme binding
AS52_05186	COG2385	sporulation resulting in formation of a cellular spore
AS52_05189	COG4836	Membrane
AS52_05190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AS52_05191	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AS52_05192	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AS52_05193	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AS52_05194	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AS52_05195	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AS52_05196	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AS52_05197	COG0356	it plays a direct role in the translocation of protons across the membrane
AS52_05200	COG1404	Belongs to the peptidase S8 family
AS52_05201	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AS52_05202	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AS52_05205	COG0698	ribose 5-phosphate isomerase
AS52_05208	COG1971	Probably functions as a manganese efflux pump
AS52_05209	COG0009	L-threonylcarbamoyladenylate synthase
AS52_05213	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AS52_05216	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AS52_05218	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS52_05219	COG0191	fructose-bisphosphate aldolase activity
AS52_05220	COG2204	response regulator
AS52_05221	COG4821	SIS domain
AS52_05222	COG0504	CTP synthase activity
AS52_05224	COG1703	isobutyryl-CoA mutase activity
AS52_05224	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AS52_05224	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AS52_05226	COG1960	acyl-CoA dehydrogenase activity
AS52_05227	COG1960	acyl-CoA dehydrogenase activity
AS52_05228	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS52_05229	COG0183	Belongs to the thiolase family
AS52_05230	COG0247	lactate metabolic process
AS52_05230	COG2181	nitrate reductase activity
AS52_05231	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS52_05233	COG0018	arginyl-trna synthetase
AS52_05235	COG0010	Belongs to the arginase family
AS52_05236	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AS52_05237	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS52_05239	COG1994	Peptidase M50
AS52_05240	COG1942	4-Oxalocrotonate Tautomerase
AS52_05241	COG3465	dGTPase activity
AS52_05242	COG1078	dGTPase activity
AS52_05243	COG4844	belongs to the
AS52_05245	COG0095	Lipoate-protein ligase
AS52_05246	COG0280	phosphate acetyltransferase
AS52_05248	COG3773	Cell wall hydrolase
AS52_05250	COG2363	Small membrane protein
AS52_05252	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AS52_05254	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AS52_05255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AS52_05256	COG2508	Transcriptional regulator
AS52_05256	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AS52_05257	COG0686	Belongs to the AlaDH PNT family
AS52_05259	COG0351	phosphomethylpyrimidine kinase
AS52_05260	COG0561	phosphatase activity
AS52_05261	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS52_05262	COG1263	PTS System
AS52_05262	COG2190	(PTS) system
AS52_05262	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AS52_05264	COG0438	transferase activity, transferring glycosyl groups
AS52_05267	COG2076	Multidrug Resistance protein
AS52_05269	COG0728	peptidoglycan biosynthetic process
AS52_05272	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AS52_05273	COG4988	ABC transporter
AS52_05274	COG1294	oxidase, subunit
AS52_05275	COG1271	oxidase subunit
AS52_05276	COG3610	response to peptide
AS52_05277	COG2966	Psort location CytoplasmicMembrane, score
AS52_05278	COG1609	Transcriptional regulator
AS52_05280	COG2814	Major facilitator Superfamily
AS52_05283	COG1966	Carbon starvation protein
AS52_05284	COG0753	catalase activity
AS52_05287	COG0471	metal ion transport
AS52_05288	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AS52_05290	COG0745	RESPONSE REGULATOR receiver
AS52_05291	COG3850	Histidine kinase
AS52_05291	COG5002	protein histidine kinase activity
AS52_05294	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS52_05295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AS52_05297	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS52_05298	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AS52_05299	COG4853	Protein conserved in bacteria
AS52_05301	COG5002	protein histidine kinase activity
AS52_05302	COG0745	RESPONSE REGULATOR receiver
AS52_05307	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AS52_05308	COG0305	Participates in initiation and elongation during chromosome replication
AS52_05310	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AS52_05312	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AS52_05315	COG0012	GTP binding
AS52_05316	COG4481	Protein conserved in bacteria
AS52_05317	COG0668	transmembrane transport
AS52_05318	COG3949	Membrane
AS52_05320	COG1475	DNA binding
AS52_05321	COG1192	Involved in chromosome partitioning
AS52_05322	COG1475	DNA binding
AS52_05324	COG0445	tRNA wobble uridine modification
AS52_05325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AS52_05326	COG1847	R3H domain protein
AS52_05327	COG0706	membrane insertase activity
AS52_05328	COG0594	ribonuclease P activity
AS52_05329	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AS52_05330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AS52_05331	COG0592	DNA-directed DNA polymerase activity
AS52_05332	COG2501	S4 domain
AS52_05333	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AS52_05334	COG0187	DNA topoisomerase II activity
AS52_05335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AS52_05342	COG0516	GMP reductase activity
AS52_05342	COG0517	IMP dehydrogenase activity
AS52_05345	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AS52_05348	COG1428	Deoxynucleoside kinase
AS52_05349	COG1428	Deoxynucleoside kinase
AS52_05350	COG3858	chitin binding
AS52_05350	COG1388	LysM domain
AS52_05351	COG1335	isochorismatase
AS52_05352	COG0590	tRNA wobble adenosine to inosine editing
AS52_05353	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AS52_05354	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AS52_05355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AS52_05378	COG0277	FAD linked oxidase domain protein
AS52_05385	COG1086	Polysaccharide biosynthesis protein
AS52_05392	COG1216	Glycosyl transferase, family 2
AS52_05396	COG1216	Glycosyl transferase, family 2
AS52_05399	COG1216	Glycosyl transferase, family 2
AS52_05407	COG0438	transferase activity, transferring glycosyl groups
AS52_05424	COG4974	Belongs to the 'phage' integrase family