locus-tag class description HFZ78_00010 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HFZ78_00015 ENOG4105XN3 extracellular solute-binding protein family 1 HFZ78_00020 ENOG4108KPW sugar kinase HFZ78_00040 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HFZ78_00080 ENOG4108KYE ABC-2 type transporter HFZ78_00090 ENOG4105CJ1 ABC, transporter HFZ78_00095 ENOG4105ENE Histidine kinase HFZ78_00150 ENOG4108HKT sucrose-6-phosphate hydrolase HFZ78_00165 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HFZ78_00175 ENOG4105ETE Transcriptional regulator (LacI family HFZ78_00200 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase HFZ78_00210 ENOG4105FUY alpha subunit HFZ78_00225 ENOG4105C7K acetolactate synthase HFZ78_00230 ENOG4105CHR reductase HFZ78_00250 ENOG4108FUF Transcriptional regulator, IclR family HFZ78_00290 ENOG4108R9S DSBA oxidoreductase HFZ78_00320 ENOG4108UXE Protein tyrosine phosphatase HFZ78_00325 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HFZ78_00330 ENOG41082YX Transcriptional regulator, arsr family HFZ78_00380 ENOG4105BZU Histidine kinase HFZ78_00390 ENOG4105ID8 Transcriptional regulator, ARAC family HFZ78_00395 ENOG4105E7W lamb ycsf family protein HFZ78_00400 ENOG4105P4J Allophanate hydrolase, subunit 1 HFZ78_00425 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HFZ78_00430 ENOG410667J hydrolase HFZ78_00435 ENOG4105CQB FAD linked oxidase domain protein HFZ78_00440 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HFZ78_00445 ENOG41063TF transcriptional regulator (AraC HFZ78_00450 ENOG4105C84 Histidine ammonia-lyase HFZ78_00455 ENOG4105C54 Major Facilitator superfamily HFZ78_00460 ENOG4105E1V na solute symporter HFZ78_00470 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HFZ78_00480 ENOG4105DVW rieske (2Fe-2S) HFZ78_00485 ENOG4108JUB Transcriptional regulator HFZ78_00500 ENOG4105D7N magnesium and cobalt transport protein CorA HFZ78_00525 ENOG4105BZU Histidine kinase HFZ78_00530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HFZ78_00550 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HFZ78_00555 ENOG4105EU9 HFZ78_00570 ENOG4105EJQ L-serine dehydratase HFZ78_00585 ENOG4105EXW epimerase dehydratase HFZ78_00595 ENOG4105VRS hydrolase family 18 HFZ78_00605 ENOG4105EVU fructokinase HFZ78_00615 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HFZ78_00645 ENOG4108W7F transporter, permease HFZ78_00650 ENOG4108JJB ABC transporter HFZ78_00655 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HFZ78_00660 ENOG4105ETU transcriptional activator (TenA HFZ78_00665 ENOG4105DKK Benzoate HFZ78_00670 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HFZ78_00675 ENOG4105CNN ABC, transporter HFZ78_00680 ENOG4105C2J ABC transporter HFZ78_00685 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HFZ78_00690 ENOG4108RVA ribokinase HFZ78_00695 ENOG4105ETE Transcriptional regulator (LacI family HFZ78_00705 ENOG4107QJZ Glycosyl transferase, family 2 HFZ78_00720 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HFZ78_00725 ENOG4105CZ9 Domain of unknown function (DU1801) HFZ78_00735 ENOG4108U5N UPF0316 protein HFZ78_00755 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HFZ78_00760 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HFZ78_00765 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HFZ78_00780 ENOG4105E1V na solute symporter HFZ78_00800 ENOG4105CHH sulfate transporter HFZ78_00805 ENOG4108V2W Carbonate dehydratase HFZ78_00810 ENOG4105K56 Transcriptional regulator HFZ78_00820 ENOG4105PTM secreted protein HFZ78_00830 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HFZ78_00835 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HFZ78_00845 ENOG4105J4Q Transcriptional regulator HFZ78_00850 ENOG4105D2S major facilitator superfamily HFZ78_00885 ENOG4105N82 Endonuclease HFZ78_00925 ENOG4105C4B ABC transporter, permease HFZ78_00930 ENOG4108IXI (ABC) transporter HFZ78_00940 ENOG4105C09 Bile acid HFZ78_01110 ENOG4105BZ4 penicillin-binding protein HFZ78_01115 ENOG4105C8I hydrolase, family 38 HFZ78_01120 ENOG4105DM4 PTS System HFZ78_01130 ENOG4105BZW Glycerate kinase HFZ78_01135 ENOG4105DG6 mannose-6-phosphate isomerase HFZ78_01165 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HFZ78_01175 ENOG4105C6Z Gluconate HFZ78_01185 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HFZ78_01215 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HFZ78_01220 ENOG4105F8D glycoside hydrolase family 4 HFZ78_01225 ENOG4105VCP PTS System HFZ78_01230 ENOG4105VZJ PTS System HFZ78_01240 ENOG4105CK1 PTS System HFZ78_01255 ENOG4108SU4 UPF0309 protein HFZ78_01260 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HFZ78_01270 ENOG4105RD7 BadF BadG BcrA BcrD HFZ78_01350 ENOG4105DRR Transcriptional regulator, GntR family HFZ78_01355 ENOG4105CHM Aminotransferase HFZ78_01360 ENOG4105DJB Major Facilitator Superfamily HFZ78_01365 ENOG4105JSC dimethylmenaquinone methyltransferase HFZ78_01375 ENOG4107TUM Amidinotransferase HFZ78_01380 ENOG4105E1K spore germination protein HFZ78_01390 ENOG4108Q5U germination protein, ger(x)c family HFZ78_01415 ENOG4108RCF TRANSCRIPTIONal HFZ78_01440 ENOG41069ER domain protein HFZ78_01445 ENOG4105BZ1 (ABC) transporter HFZ78_01450 ENOG4105BZ1 (ABC) transporter HFZ78_01455 ENOG4105EVU fructokinase HFZ78_01460 ENOG41066F8 ROK family HFZ78_01465 ENOG4105CS2 ec 3.2.1.21 HFZ78_01470 ENOG4105EQD regulatoR HFZ78_01475 ENOG4105C2F Histidine kinase HFZ78_01485 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HFZ78_01515 ENOG4105C8I hydrolase, family 38 HFZ78_01535 ENOG4105C0R drug resistance transporter emrb qaca subfamily HFZ78_01545 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HFZ78_01550 ENOG4105C87 Aminotransferase class I and II HFZ78_01570 ENOG4107TVC Glycosyl transferase, family 2 HFZ78_01590 ENOG4105E5Q amino acid AbC transporter HFZ78_01595 ENOG4107R0W ABC transporter HFZ78_01600 ENOG4105CDA abc transporter atp-binding protein HFZ78_01605 ENOG4108IQI permease HFZ78_01610 ENOG4105C84 Histidine ammonia-lyase HFZ78_01620 ENOG4107RB3 L-asparaginase HFZ78_01625 ENOG4105X3H Excalibur domain protein HFZ78_01630 ENOG4105NX3 Membrane HFZ78_01640 ENOG4108TU7 Inherit from COG: (ABC) transporter HFZ78_01645 ENOG4105CJ1 ABC, transporter HFZ78_01650 ENOG4105VMP Transcriptional regulator HFZ78_01665 ENOG4105JFG SpoIID LytB domain protein HFZ78_01690 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HFZ78_01695 ENOG4107MV2 Inherit from COG: Hemolysin-type calcium-binding HFZ78_01705 ENOG4105EY8 ABC transporter HFZ78_01845 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HFZ78_01855 ENOG4105C6Y Udp-glucose 6-dehydrogenase HFZ78_01870 ENOG4108UW5 maltose o-acetyltransferase HFZ78_01880 ENOG4107T8Q Glycosyl transferase (Group 1 HFZ78_01890 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HFZ78_01900 ENOG4106WTF Glycosyl transferase, family 2 HFZ78_01920 ENOG4105C0K Gdp-mannose 4,6-dehydratase HFZ78_01925 ENOG4105C30 Nad-dependent epimerase dehydratase HFZ78_01930 ENOG4105D3Q Sugar transferase HFZ78_01935 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HFZ78_01940 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HFZ78_01945 ENOG4107YJ4 chain length determinant protein HFZ78_01950 ENOG4105HTX biosynthesis protein HFZ78_01965 ENOG4105K4H Nlp p60 protein HFZ78_01970 ENOG4105KAF membrAne HFZ78_01985 ENOG41068WN HFZ78_02015 ENOG4108S3Y transcriptional regulator HFZ78_02020 ENOG4105CS2 ec 3.2.1.21 HFZ78_02025 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HFZ78_02030 ENOG4105ETE Transcriptional regulator (LacI family HFZ78_02035 ENOG41079KZ Major Facilitator Superfamily HFZ78_02105 ENOG4105KPY Small multidrug resistance protein HFZ78_02110 ENOG410667J hydrolase HFZ78_02120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HFZ78_02125 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HFZ78_02150 ENOG4105DA5 (ABC) transporter HFZ78_02155 ENOG41069JR HFZ78_02165 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HFZ78_02180 ENOG4107GRR phosphate transport regulator HFZ78_02200 ENOG4105DGI Alkaline phosphatase HFZ78_02230 ENOG4105C0D helicase HFZ78_02255 ENOG4105DXX methyltransferase HFZ78_02260 ENOG4105CV8 reductase HFZ78_02265 ENOG4105F27 Major Facilitator HFZ78_02270 ENOG4105KVH Transcriptional regulator HFZ78_02280 ENOG41069ER domain protein HFZ78_02300 ENOG4105Z8H single-stranded DNA-binding protein HFZ78_02325 ENOG4105DFF Rod shape-determining protein mreb HFZ78_02330 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HFZ78_02340 ENOG41080UX Methyltransferase HFZ78_02355 ENOG4107RVG penicillin-binding protein HFZ78_02365 ENOG4105FRN stage II sporulation protein HFZ78_02400 ENOG4106778 Protein of unknown function (DUF1146) HFZ78_02420 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HFZ78_02425 ENOG4108RMU ferritin dps family protein HFZ78_02430 ENOG41064BQ Phosphatase HFZ78_02440 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HFZ78_02445 ENOG4105WN5 stage II sporulation protein HFZ78_02450 ENOG4107SGM protein serine threonine phosphatase HFZ78_02455 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HFZ78_02460 ENOG4105FUA antagonist HFZ78_02465 ENOG4107MMM Anti-sigma-factor antagonist HFZ78_02500 ENOG4105C37 (CBS) domain HFZ78_02520 ENOG4107KM7 Heat induced stress protein YflT HFZ78_02525 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HFZ78_02530 ENOG4105C8S subunit m HFZ78_02535 ENOG4105D65 subunit l HFZ78_02540 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HFZ78_02555 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HFZ78_02560 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HFZ78_02565 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HFZ78_02570 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HFZ78_02575 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HFZ78_02585 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HFZ78_02590 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HFZ78_02595 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HFZ78_02600 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HFZ78_02605 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HFZ78_02615 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HFZ78_02620 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HFZ78_02625 ENOG41062M3 atp synthase HFZ78_02635 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HFZ78_02645 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HFZ78_02655 ENOG4108UIC UPF0340 protein HFZ78_02660 ENOG4108YZG isomerase HFZ78_02670 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HFZ78_02675 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HFZ78_02685 ENOG4108ZXQ stage ii sporulation protein r HFZ78_02695 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HFZ78_02700 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HFZ78_02710 ENOG4107104 thymidine kinase HFZ78_02715 ENOG4105VFB Binds the 23S rRNA (By similarity) HFZ78_02720 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HFZ78_02725 ENOG4105CBT Fructose-1,6-bisphosphatase HFZ78_02740 ENOG4105D2N Aldolase HFZ78_02745 ENOG410812K response regulator receiver protein HFZ78_02755 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HFZ78_02770 ENOG4105D5P Methylmalonyl-coA mutase HFZ78_02780 ENOG4105C1G acyl-Coa dehydrogenase HFZ78_02785 ENOG4105C1G acyl-Coa dehydrogenase HFZ78_02790 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HFZ78_02800 ENOG4105DF6 Fe-S oxidoreductase HFZ78_02820 ENOG4105C75 arginyL-tRNA synthetase HFZ78_02830 ENOG4105CYW agmatinase HFZ78_02835 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HFZ78_02840 ENOG4105BZ4 penicillin-binding protein HFZ78_02845 ENOG4108XFG YwhD family HFZ78_02850 ENOG4108Z4T Peptidase M50 HFZ78_02865 ENOG4105DCI Phosphohydrolase HFZ78_02870 ENOG4105QAT UPF0741 protein HFZ78_02875 ENOG4108VCI transcription factor, rsfa family HFZ78_02880 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HFZ78_02885 ENOG4108IJ2 phosphate acetyltransferase HFZ78_02890 ENOG4107JTW chlorite dismutase HFZ78_02910 ENOG4105D06 uba thif-type nad fad binding protein HFZ78_02915 ENOG4105M00 molybdopterin converting factor, subunit 1 HFZ78_02920 ENOG4108ZAF Molybdopterin HFZ78_02925 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HFZ78_02930 ENOG4105CVM Molybdenum cofactor synthesis domain protein HFZ78_02935 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HFZ78_02945 ENOG4105DWF phosphomethylpyrimidine kinase HFZ78_02955 ENOG4108TN2 lmbE family HFZ78_02960 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HFZ78_02970 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) HFZ78_02990 ENOG4105CJ1 ABC, transporter HFZ78_03000 ENOG4105D8V Glucose sorbosone dehydrogenase HFZ78_03005 ENOG410667J hydrolase HFZ78_03035 ENOG4108Z66 YbaK ebsC protein HFZ78_03045 ENOG4108IV0 ABC, transporter HFZ78_03050 ENOG4105C0Z ABC transporter HFZ78_03055 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HFZ78_03060 ENOG4105C32 Amino acid ABC transporter (Permease) HFZ78_03065 ENOG4105CP9 extracellular ligand-binding receptor HFZ78_03070 ENOG41079KZ Major Facilitator Superfamily HFZ78_03075 ENOG4105BZ1 (ABC) transporter HFZ78_03080 ENOG4105BZ1 (ABC) transporter HFZ78_03115 ENOG4105CIG ABC transporter HFZ78_03130 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HFZ78_03165 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HFZ78_03170 ENOG4105FE9 pseudouridine synthase HFZ78_03185 ENOG4107QM2 Aldo Keto reductase HFZ78_03190 ENOG41069ER domain protein HFZ78_03205 ENOG4105C5Y PTS System HFZ78_03210 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HFZ78_03215 ENOG4105FDP GntR family transcriptional regulator HFZ78_03225 ENOG4108KPW sugar kinase HFZ78_03230 ENOG4105CDA abc transporter atp-binding protein HFZ78_03235 ENOG4105EAD ABC transporter HFZ78_03240 ENOG4108HW3 (ABC) transporter HFZ78_03245 ENOG4107QZW Altronate oxidoreductase HFZ78_03255 ENOG4105CTX dehydratase HFZ78_03260 ENOG4105CPQ Dehydrogenase HFZ78_03265 ENOG4108I5G Major Facilitator superfamily HFZ78_03270 ENOG4107XBN GntR Family Transcriptional Regulator HFZ78_03285 ENOG4105DEI Mannitol dehydrogenase HFZ78_03290 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HFZ78_03295 ENOG4105CPQ Dehydrogenase HFZ78_03300 ENOG4108I5G Major Facilitator superfamily HFZ78_03305 ENOG4108J5H Homocysteine s-methyltransferase HFZ78_03310 ENOG4108IQI permease HFZ78_03315 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HFZ78_03335 ENOG4107F3J Amp-dependent synthetase and ligase HFZ78_03340 ENOG4107ZYJ bioY protein HFZ78_03365 ENOG4108TVJ Nitroreductase HFZ78_03375 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HFZ78_03385 ENOG4105C0H protease HFZ78_03390 ENOG4105Q2H domain protein HFZ78_03405 ENOG4105BZU Histidine kinase HFZ78_03410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HFZ78_03415 ENOG4108K5P (LipO)protein HFZ78_03440 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HFZ78_03450 ENOG4105CDU Replicative dna helicase HFZ78_03460 ENOG4105BZR domain protein HFZ78_03470 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HFZ78_03475 ENOG4108UUM single-stranded DNA-binding protein HFZ78_03480 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HFZ78_03485 ENOG4105C3G gtp-binding protein HFZ78_03495 ENOG4108J2R molybdopterin oxidoreductase HFZ78_03500 ENOG4105VDK protein, conserved in bacteria HFZ78_03505 ENOG4105D8X mechanosensitive ion channel HFZ78_03510 ENOG4108ZDA Sporulation protein YyaC HFZ78_03520 ENOG4105FA0 parb-like partition protein HFZ78_03525 ENOG4107QJE Chromosome Partitioning Protein HFZ78_03530 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) HFZ78_03540 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HFZ78_03545 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HFZ78_03555 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HFZ78_03560 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HFZ78_03570 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HFZ78_03575 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HFZ78_03580 ENOG410848D S4 domain protein YaaA HFZ78_03585 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HFZ78_03595 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HFZ78_03600 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HFZ78_03635 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HFZ78_03645 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HFZ78_03650 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HFZ78_03665 ENOG4105ZMH deoxynucleoside kinase HFZ78_03675 ENOG4105VRS hydrolase family 18 HFZ78_03680 ENOG4105GTG Isochorismatase HFZ78_03685 ENOG4108Z6B deaminase HFZ78_03695 ENOG4105C6E dna polymerase iii HFZ78_03700 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HFZ78_03705 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HFZ78_03715 ENOG41067KS pro-sigma K processing HFZ78_03750 ENOG4105CXN decarboxylase HFZ78_03755 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HFZ78_03760 ENOG4105X0R protein from nitrogen regulatory protein P-II HFZ78_03765 ENOG4105FA2 dna polymerase iii HFZ78_03770 ENOG4105MA4 psp1 domain protein HFZ78_03775 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) HFZ78_03780 ENOG41060K3 Methyltransferase HFZ78_03785 ENOG4105VC4 domain protein HFZ78_03790 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HFZ78_03795 ENOG4105KRN Transcriptional regulator, abrb family HFZ78_03805 ENOG4105F8V Hydrolase, tatD family HFZ78_03810 ENOG41069ER domain protein HFZ78_03815 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HFZ78_03820 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HFZ78_03825 ENOG4105XFA sporulation peptidase YabG HFZ78_03830 ENOG4105W42 Veg protein HFZ78_03845 ENOG4105DFT pur operon repressor HFZ78_03850 ENOG4105KME endoribonuclease L-psp HFZ78_03855 ENOG4105K4W Could be involved in septation (By similarity) HFZ78_03860 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HFZ78_03870 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HFZ78_03875 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HFZ78_03885 ENOG4108JA2 transcriptioN-repair coupling factor HFZ78_03890 ENOG4108M14 stage v sporulation protein t HFZ78_03900 ENOG4108IY2 MazG family HFZ78_03905 ENOG41082I2 s4 domain protein HFZ78_03910 ENOG4105VYY sporulation protein yabp HFZ78_03925 ENOG41060GV RNA binding s1 domain protein HFZ78_03945 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HFZ78_03950 ENOG4108UGV hypoxanthine phosphoribosyltransferase HFZ78_03955 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HFZ78_03960 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HFZ78_03965 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HFZ78_03970 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HFZ78_03975 ENOG4105C6T cysteine synthase HFZ78_03980 ENOG4105EEI dihydropteroate synthase HFZ78_03985 ENOG4105KRF dihydroneopterin aldolase HFZ78_03990 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HFZ78_04000 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HFZ78_04090 ENOG4108Z0C Uvrb UvrC protein HFZ78_04095 ENOG41066A3 ATP guanido phosphotransferase HFZ78_04105 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HFZ78_04115 ENOG4105CTP PilT protein domain protein HFZ78_04120 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HFZ78_04125 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HFZ78_04130 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HFZ78_04135 ENOG4105D7W serine acetyltransferase HFZ78_04140 ENOG4105C8N cysteinyl-tRNA synthetase HFZ78_04150 ENOG4105C2N RNA methyltransferase TrmH family group 3 HFZ78_04155 ENOG4105M0M Tetracycline resistance protein HFZ78_04160 ENOG4105QIV RNA polymerase HFZ78_04175 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HFZ78_04185 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HFZ78_04190 ENOG4108VZM 50s ribosomal protein L10 HFZ78_04200 ENOG4107Y49 methyltransferase HFZ78_04205 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HFZ78_04215 ENOG4105XPM ribosomal protein HFZ78_04220 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HFZ78_04225 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HFZ78_04230 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HFZ78_04235 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HFZ78_04240 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HFZ78_04245 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HFZ78_04250 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HFZ78_04255 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HFZ78_04260 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HFZ78_04275 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HFZ78_04280 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HFZ78_04295 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HFZ78_04300 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HFZ78_04315 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HFZ78_04320 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HFZ78_04330 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HFZ78_04335 ENOG4105VPB 50S ribosomal protein L30 HFZ78_04345 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HFZ78_04350 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HFZ78_04355 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HFZ78_04360 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HFZ78_04370 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HFZ78_04375 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HFZ78_04380 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HFZ78_04385 ENOG4108ZT0 50S ribosomal protein l17 HFZ78_04390 ENOG4108JJB ABC transporter HFZ78_04395 ENOG4108JJB ABC transporter HFZ78_04400 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HFZ78_04405 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HFZ78_04410 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HFZ78_04415 ENOG4108UJD 30S ribosomal protein S9 HFZ78_04430 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HFZ78_04440 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HFZ78_04445 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HFZ78_04455 ENOG41080XP Cbs domain HFZ78_04465 ENOG4108IJ0 Aspartate ammonia-lyase HFZ78_04485 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HFZ78_04495 ENOG4105C6Y Udp-glucose 6-dehydrogenase HFZ78_04505 ENOG4108IAJ Nad-dependent epimerase dehydratase HFZ78_04515 ENOG4105WH1 Two component transcriptional regulator luxr family HFZ78_04520 ENOG4105BZU Histidine kinase HFZ78_04525 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HFZ78_04550 ENOG4105D1F ATP-binding protein HFZ78_04565 ENOG4108NMV polysaccharide deacetylase HFZ78_04635 ENOG4105EMN RNA polymerase sigma factor HFZ78_04645 ENOG4105C8B TIGR00159 family HFZ78_04650 ENOG4107U5W ybbr family HFZ78_04655 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HFZ78_04660 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HFZ78_04670 ENOG4105ETD TRANSCRIPTIONal HFZ78_04685 ENOG4105BZU Histidine kinase HFZ78_04690 ENOG41090MY MarR family Transcriptional regulator HFZ78_04695 ENOG4108VGI doxx family HFZ78_04710 ENOG4105JQZ Methyltransferase HFZ78_04725 ENOG4108IUW ABC transporter HFZ78_04755 ENOG4105C75 arginyL-tRNA synthetase HFZ78_04765 ENOG4105C0X amino acid HFZ78_04775 ENOG4107T5V SNARE associated Golgi HFZ78_04780 ENOG4105CJW magnesium transporter HFZ78_04795 ENOG4105CPF Cell wall formation (By similarity) HFZ78_04800 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HFZ78_04815 ENOG410905X membrane-flanked domain protein HFZ78_04820 ENOG4105CKV Membrane HFZ78_04830 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HFZ78_04835 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HFZ78_04850 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HFZ78_04865 ENOG410906U SprT-like HFZ78_04940 ENOG4105K8N protein family UPF0079, ATPase HFZ78_04945 ENOG41072GX Peptidase M22 Glycoprotease HFZ78_04950 ENOG410801F ribosomal-protein-alanine acetyltransferase HFZ78_04960 ENOG4105C5H ABC transporter HFZ78_04965 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HFZ78_04970 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HFZ78_04975 ENOG4105C6K Malic enzyme HFZ78_04990 ENOG4108MRH transcriptional regulatory protein HFZ78_05000 ENOG4105C6K Malic enzyme HFZ78_05030 ENOG4108TYN CAAX amino terminal protease family protein HFZ78_05060 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HFZ78_05065 ENOG4105DRS transport system, permease HFZ78_05080 ENOG4108HKT sucrose-6-phosphate hydrolase HFZ78_05085 ENOG4105E2V Glycosyltransferase 36 HFZ78_05090 ENOG4105C7S Dehydrogenase HFZ78_05095 ENOG4108S4H thioesterase Superfamily protein HFZ78_05115 ENOG4105D82 Glutamate dehydrogenase HFZ78_05125 ENOG41080XP Cbs domain HFZ78_05135 ENOG41087PP glycosyltransferase MGT family HFZ78_05150 ENOG4105PGZ NB-ARC domain HFZ78_05155 ENOG4105CPQ Dehydrogenase HFZ78_05160 ENOG4105CT4 transporter HFZ78_05255 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HFZ78_05275 ENOG4105C7N Xanthine uracil vitamin C permease HFZ78_05280 ENOG4105CID antiterminator HFZ78_05305 ENOG4105D8X mechanosensitive ion channel HFZ78_05315 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HFZ78_05320 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HFZ78_05325 ENOG4105C83 adenylosuccinate lyase HFZ78_05335 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HFZ78_05340 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HFZ78_05360 ENOG4108V3E phosphoribosylglycinamide formyltransferase HFZ78_05365 ENOG4105DC1 bifunctional purine biosynthesis protein purh HFZ78_05370 ENOG4105C12 Phosphoribosylglycinamide synthetase HFZ78_05385 ENOG4108R5T secreted protein HFZ78_05390 ENOG4105KGF protein, YerC YecD HFZ78_05395 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) HFZ78_05400 ENOG4105C4R Atp-dependent dna helicase HFZ78_05405 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HFZ78_05415 ENOG4105C26 Dehydrogenase HFZ78_05440 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HFZ78_05445 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HFZ78_05450 ENOG4108Z73 Siroheme synthase HFZ78_05455 ENOG4107QP3 malate synthase g HFZ78_05470 ENOG4108X3M OsmC Ohr family protein HFZ78_05485 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HFZ78_05490 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HFZ78_05495 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HFZ78_05500 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HFZ78_05510 ENOG4105CK7 Sodium proline symporter HFZ78_05525 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HFZ78_05535 ENOG4105EMN RNA polymerase sigma factor HFZ78_05555 ENOG4105CBD Diacylglycerol kinase HFZ78_05565 ENOG4105DAP Nicotinate phosphoribosyltransferase HFZ78_05575 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HFZ78_05585 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HFZ78_05590 ENOG4105K4H Nlp p60 protein HFZ78_05615 ENOG4105BZU Histidine kinase HFZ78_05620 ENOG4108XRC Protein of unknown function (DUF458) HFZ78_05630 ENOG4105WH1 Two component transcriptional regulator luxr family HFZ78_05655 ENOG4105C2F Histidine kinase HFZ78_05660 ENOG4105EQD regulatoR HFZ78_05665 ENOG4105XN3 extracellular solute-binding protein family 1 HFZ78_05680 ENOG4105MU9 integral membrane protein HFZ78_05685 ENOG4105DSG hydrolase family 43 HFZ78_05695 ENOG4105DQ5 transport system permease protein HFZ78_05700 ENOG4105EHG Permease protein HFZ78_05705 ENOG4105E0A ABC, transporter HFZ78_05710 ENOG4105CAY ferredoxin--nadp reductase HFZ78_05725 ENOG4105CEU Arginine dihydrolase HFZ78_05730 ENOG4106V2I dimethylaminohydrolase HFZ78_05735 ENOG4108IQI permease HFZ78_05745 ENOG4105G6Z alkaline phosphatase HFZ78_05760 ENOG4105EQD regulatoR HFZ78_05765 ENOG4105C2F Histidine kinase HFZ78_05785 ENOG4105CNT hydrolase family 2 HFZ78_05795 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HFZ78_05800 ENOG4105CMR udp-glucose 4-epimerase HFZ78_05805 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase HFZ78_05810 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HFZ78_05840 ENOG4105C2F Histidine kinase HFZ78_05845 ENOG4107YTP response regulator receiver protein HFZ78_05850 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HFZ78_05855 ENOG4105C2J ABC transporter HFZ78_05860 ENOG4108HWV )-transporter HFZ78_05865 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HFZ78_05875 ENOG4107QP7 CoA-transferase subunit A HFZ78_05880 ENOG4107QNJ CoA-transferase subunit B HFZ78_05885 ENOG4105CY2 Citrate transporter HFZ78_05890 ENOG4105DTD Dehydrogenase HFZ78_05895 ENOG4108JUB Transcriptional regulator HFZ78_05900 ENOG4105BZ1 (ABC) transporter HFZ78_05910 ENOG4105BZU Histidine kinase HFZ78_05925 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HFZ78_05930 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HFZ78_05935 ENOG4107R6U sodium dicarboxylate symporter HFZ78_05940 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HFZ78_05965 ENOG4105C2F Histidine kinase HFZ78_05975 ENOG4107VQW regulatoR HFZ78_05985 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HFZ78_05990 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HFZ78_06005 ENOG4105CNT hydrolase family 2 HFZ78_06010 ENOG4105E8R UPF0173 metal-dependent hydrolase HFZ78_06015 ENOG4105CP9 extracellular ligand-binding receptor HFZ78_06025 ENOG4105YVM Phosphoesterase, PA-phosphatase related HFZ78_06030 ENOG4105C6Y Udp-glucose 6-dehydrogenase HFZ78_06055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HFZ78_06060 ENOG4105BZU Histidine kinase HFZ78_06065 ENOG4108X4Q Hydrolase HFZ78_06150 ENOG4105FKQ transcriptional regulator HFZ78_06155 ENOG4107QW3 Sucrose phosphorylase HFZ78_06160 ENOG4105WEM extracellular solute-binding protein HFZ78_06165 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HFZ78_06170 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HFZ78_06175 ENOG4107RRD Dehydrogenase HFZ78_06180 ENOG4107TYA transient receptor potential locus HFZ78_06185 ENOG4105CK5 oxidoreductase HFZ78_06190 ENOG4105C71 hydrolase family 65, central catalytic HFZ78_06195 ENOG4105BZW Glycerate kinase HFZ78_06200 ENOG4107URF beta-phospho-glucomutase HFZ78_06220 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HFZ78_06230 ENOG4105C1B dTDP-glucose 4-6-dehydratase HFZ78_06240 ENOG4107T8Q Glycosyl transferase (Group 1 HFZ78_06245 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HFZ78_06270 ENOG4105K64 Glycosyl transferase, family 2 HFZ78_06295 ENOG4107RIQ Sulfate adenylate transferase HFZ78_06300 ENOG410635A Membrane HFZ78_06310 ENOG4105CPK Glycosyl transferase (Group 1 HFZ78_06325 ENOG4105C5E polysaccharide biosynthesis protein HFZ78_06335 ENOG4105C1J atp-dependent rna helicase HFZ78_06340 ENOG4105ECK Fatty Acid Desaturase HFZ78_06345 ENOG4108S01 response regulator HFZ78_06350 ENOG4105CN5 Metallo-Beta-Lactamase HFZ78_06355 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HFZ78_06380 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HFZ78_06400 ENOG4105D7K pfkb domain protein HFZ78_06420 ENOG4108VA3 3-hexulose-6-phosphate synthase HFZ78_06425 ENOG41080HJ 6-phospho 3-hexuloisomerase HFZ78_06430 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HFZ78_06440 ENOG4105C7B Threonine dehydratase HFZ78_06450 ENOG4108QY0 Membrane HFZ78_06455 ENOG4107SUZ Sodium/hydrogen exchanger family HFZ78_06460 ENOG4105CM2 brancheD-chain amino acid aminotransferase HFZ78_06480 ENOG4108YZA Nitrogen regulatory protein pii HFZ78_06490 ENOG41067AE Membrane-bound metal-dependent hydrolase HFZ78_06495 ENOG4105BZF Glycosyl transferase (Group 1 HFZ78_06500 ENOG4105G6Z alkaline phosphatase HFZ78_06520 ENOG4105G9B Transcriptional regulator HFZ78_06530 ENOG4105CI2 imidazolone-5-propionate hydrolase HFZ78_06540 ENOG4105DZC cytosine deaminase HFZ78_06545 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HFZ78_06555 ENOG4105EQD regulatoR HFZ78_06560 ENOG4105C2F Histidine kinase HFZ78_06565 ENOG4108JQ7 (ABC) transporter HFZ78_06570 ENOG4105C3U ABC transporter HFZ78_06580 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HFZ78_06585 ENOG4105DEF Extracellular solute-binding protein, family 5 HFZ78_06590 ENOG4105DZC cytosine deaminase HFZ78_06595 ENOG4105DZC cytosine deaminase HFZ78_06605 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HFZ78_06610 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HFZ78_06630 ENOG4105E8V Alpha Beta Hydrolase Fold protein HFZ78_06635 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HFZ78_06645 ENOG4108URH decarboxylase HFZ78_06650 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HFZ78_06665 ENOG4105NBK UPF0345 protein HFZ78_06690 ENOG4105CH2 amidohydrolase HFZ78_06715 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HFZ78_06740 ENOG4108PB2 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HFZ78_06745 ENOG4105Y7M Transcriptional regulator, TetR family HFZ78_06790 ENOG4105C54 Major Facilitator superfamily HFZ78_06800 ENOG4105ERH Fumarylacetoacetate hydrolase HFZ78_06805 ENOG4105C94 Transporter HFZ78_06810 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HFZ78_06815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HFZ78_06820 ENOG4105VCP PTS System HFZ78_06830 ENOG4105CK1 PTS System HFZ78_06835 ENOG4105CS2 ec 3.2.1.21 HFZ78_06840 ENOG4105BZU Histidine kinase HFZ78_06865 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HFZ78_06870 ENOG4107HP6 Transcriptional regulator HFZ78_06880 ENOG4105CTX dehydratase HFZ78_06885 ENOG4105CTX dehydratase HFZ78_06895 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HFZ78_06900 ENOG4105ERH Fumarylacetoacetate hydrolase HFZ78_06915 ENOG4108ZCF integral membrane protein HFZ78_06930 ENOG4105CHJ isochorismatase hydrolase HFZ78_06960 ENOG4105D9N nucleoside HFZ78_06965 ENOG4105IW1 AmiS UreI transporter HFZ78_06975 ENOG4105CUB amino acid HFZ78_06980 ENOG4105EFZ amidohydrolase HFZ78_06990 ENOG4108JYZ YitT family HFZ78_07005 ENOG4105EFA 4-hydroxyphenylacetate HFZ78_07025 ENOG4105DTN riboflavin biosynthesis protein ribF HFZ78_07030 ENOG4105CSH Transporter HFZ78_07035 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HFZ78_07040 ENOG4105CUB amino acid HFZ78_07050 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HFZ78_07060 ENOG4105CUB amino acid HFZ78_07065 ENOG4105D82 Glutamate dehydrogenase HFZ78_07075 ENOG4108JUB Transcriptional regulator HFZ78_07090 ENOG4108JPW Aminotransferase HFZ78_07095 ENOG4105C26 Dehydrogenase HFZ78_07100 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HFZ78_07110 ENOG4105CNN ABC, transporter HFZ78_07115 ENOG4105CMG Carbohydrate kinase HFZ78_07135 ENOG4108PCX Major Facilitator HFZ78_07145 ENOG4108Q5Y Membrane HFZ78_07150 ENOG4105K63 Thioredoxin HFZ78_07170 ENOG41069H0 dihydroorotase EC 3.5.2.3 HFZ78_07190 ENOG4105FDP GntR family transcriptional regulator HFZ78_07195 ENOG4105C6Z Gluconate HFZ78_07200 ENOG4108Z0Z intracellular protease Pfpi family HFZ78_07230 ENOG4105DWT malate dehydrogenase (quinone) HFZ78_07250 ENOG4105UQX Mate efflux family protein HFZ78_07270 ENOG4108X3M OsmC Ohr family protein HFZ78_07280 ENOG410900G Protein of unknown function (DUF421) HFZ78_07315 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HFZ78_07350 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HFZ78_07370 ENOG4108KC1 acyl-Coa dehydrogenase HFZ78_07380 ENOG4105DTN riboflavin biosynthesis protein ribF HFZ78_07405 ENOG4105DJ2 Major Facilitator Superfamily HFZ78_07435 ENOG4105IJJ transcriptional regulator, crp fnr family HFZ78_07470 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) HFZ78_07475 ENOG4105BZU Histidine kinase HFZ78_07505 ENOG4107STQ Multicopper oxidase HFZ78_07525 ENOG41073R8 VanW family HFZ78_07545 ENOG4108Q5U germination protein, ger(x)c family HFZ78_07550 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HFZ78_07555 ENOG4105CMG Carbohydrate kinase HFZ78_07560 ENOG4107QNK )-transporter HFZ78_07570 ENOG4105E2R ROK family HFZ78_07575 ENOG4105C5I Dehydrogenase HFZ78_07580 ENOG4105K4I Scp-like extracellular HFZ78_07630 ENOG4105C0D helicase HFZ78_07670 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HFZ78_07675 ENOG4107S9D Alpha beta hydrolase HFZ78_07680 ENOG4105C1Q protoporphyrinogen oxidase HFZ78_07700 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HFZ78_07705 ENOG4108I5D sulfate abc transporter HFZ78_07710 ENOG4105ECW sulfate abc transporter HFZ78_07720 ENOG41061GT Aldolase HFZ78_07730 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HFZ78_07755 ENOG4105D4B ABC, transporter HFZ78_07765 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HFZ78_07775 ENOG4105CMG Carbohydrate kinase HFZ78_07785 ENOG4108RPX mosc domain containing protein HFZ78_07805 ENOG4105D9U N-acetyltransferase HFZ78_07810 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HFZ78_07860 ENOG4105DR4 Methyltransferase HFZ78_07885 ENOG41082YX Transcriptional regulator, arsr family HFZ78_07890 ENOG4108W8B Beta-lactamase domain protein HFZ78_07925 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HFZ78_07960 ENOG4105C2F Histidine kinase HFZ78_07965 ENOG4107VQW regulatoR HFZ78_07975 ENOG4105EQD regulatoR HFZ78_08000 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HFZ78_08010 ENOG4108HKT sucrose-6-phosphate hydrolase HFZ78_08020 ENOG410667J hydrolase HFZ78_08025 ENOG4105ETE Transcriptional regulator (LacI family HFZ78_08035 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HFZ78_08040 ENOG4105E0S extracellular solute-binding protein family 1 HFZ78_08055 ENOG4108HKT sucrose-6-phosphate hydrolase HFZ78_08065 ENOG4108HKT sucrose-6-phosphate hydrolase HFZ78_08070 ENOG4107R3K hydrolase HFZ78_08075 ENOG4105EDQ levansucrase EC 2.4.1.10 HFZ78_08080 ENOG4105EDQ levansucrase EC 2.4.1.10 HFZ78_08085 ENOG4105EDQ levansucrase EC 2.4.1.10 HFZ78_08090 ENOG4105C5Y PTS System HFZ78_08105 ENOG4105FKQ transcriptional regulator HFZ78_08110 ENOG4105D9R oxidoreductase HFZ78_08115 ENOG4108WFR AraC Family Transcriptional Regulator HFZ78_08125 ENOG4105CK5 oxidoreductase HFZ78_08150 ENOG4107YY3 extracellular solute-binding protein family 1 HFZ78_08200 ENOG4107Y2X deaminase HFZ78_08215 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HFZ78_08230 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HFZ78_08235 ENOG4108YZ9 Urea amidohydrolase subunit gamma HFZ78_08240 ENOG4105KI2 Urea amidohydrolase subunit beta HFZ78_08250 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HFZ78_08255 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HFZ78_08265 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HFZ78_08290 ENOG4105K78 MarR family Transcriptional regulator HFZ78_08295 ENOG4108UT2 hemolysin iii HFZ78_08325 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HFZ78_08330 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HFZ78_08335 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HFZ78_08340 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HFZ78_08345 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HFZ78_08350 ENOG4108ZP8 Acetolactate synthase small subunit HFZ78_08355 ENOG4105C7K acetolactate synthase HFZ78_08360 ENOG4105C01 Dihydroxy-acid dehydratase HFZ78_08365 ENOG4105CM2 brancheD-chain amino acid aminotransferase HFZ78_08370 ENOG4107S1V Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HFZ78_08385 ENOG4105V75 Transcriptional regulator HFZ78_08405 ENOG4106PMH Extracellular solute-binding protein family 3 HFZ78_08410 ENOG4105E5Q amino acid AbC transporter HFZ78_08430 ENOG4105CSU acyl-Coa dehydrogenase HFZ78_08440 ENOG4105E0Y RtcB Protein HFZ78_08450 ENOG4105CZM Major Facilitator HFZ78_08460 ENOG4108JUB Transcriptional regulator HFZ78_08475 ENOG4105CHU acetyl-coa acetyltransferase HFZ78_08485 ENOG410846T CoA-transferase family III HFZ78_08495 ENOG4107YBY Hydrolase HFZ78_08500 ENOG4105C9U ATP-dependent DNA helicase RecQ HFZ78_08505 ENOG4108QTI )-transporter HFZ78_08520 ENOG4105ERH Fumarylacetoacetate hydrolase HFZ78_08525 ENOG4107GFK fumarate HFZ78_08530 ENOG4106DSS Tartrate dehydratase subunit alpha HFZ78_08535 ENOG4105DJB Major Facilitator Superfamily HFZ78_08545 ENOG4105C2J ABC transporter HFZ78_08550 ENOG4105CNN ABC, transporter HFZ78_08560 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HFZ78_08565 ENOG4105XN3 extracellular solute-binding protein family 1 HFZ78_08570 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HFZ78_08575 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HFZ78_08580 ENOG4108KPW sugar kinase HFZ78_08585 ENOG4105FDP GntR family transcriptional regulator HFZ78_08590 ENOG4105DWK Membrane HFZ78_08595 ENOG4107XM3 UPF0442 protein HFZ78_08635 ENOG4108HRK Histidine kinase HFZ78_08640 ENOG4105DY9 regulatoR HFZ78_08650 ENOG4105CUB amino acid HFZ78_08655 ENOG4105BZU Histidine kinase HFZ78_08660 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HFZ78_08675 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HFZ78_08705 ENOG4105BZU Histidine kinase HFZ78_08710 ENOG4105WH1 Two component transcriptional regulator luxr family HFZ78_08730 ENOG4105EE0 oxidoreductase HFZ78_08735 ENOG4105HEE Binding Domain protein HFZ78_08760 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HFZ78_08780 ENOG4105FDU atp-dependent rna helicase HFZ78_08795 ENOG4106U2H Protein of unknown function (DUF1360) HFZ78_08800 ENOG4105K4I Scp-like extracellular HFZ78_08810 ENOG41087YS Phage shock protein A HFZ78_08820 ENOG4105ENE Histidine kinase HFZ78_08825 ENOG4105WH1 Two component transcriptional regulator luxr family HFZ78_08850 ENOG4105MIR Phenylalanine 4-monooxygenase HFZ78_08855 ENOG4106I4J membrane HFZ78_08875 ENOG4105C9U ATP-dependent DNA helicase RecQ HFZ78_08880 ENOG4105C84 Histidine ammonia-lyase HFZ78_08895 ENOG4108IMY Transcriptional regulator HFZ78_08900 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HFZ78_08905 ENOG41068PA UPF0435 protein HFZ78_08915 ENOG4107U9T Pfam:Ribonuclease_BN HFZ78_08920 ENOG4105C59 p-type ATPase HFZ78_08925 ENOG4108ISG Major Facilitator HFZ78_08930 ENOG4105UPD Calcium Proton HFZ78_08935 ENOG4108VW9 Membrane HFZ78_08965 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HFZ78_08990 ENOG4105C0X amino acid HFZ78_09005 ENOG4107ZYR domain protein HFZ78_09010 ENOG4105CZN Potassium uptake protein HFZ78_09045 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HFZ78_09050 ENOG4105CPC Aldo Keto reductase HFZ78_09055 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase HFZ78_09130 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HFZ78_09140 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HFZ78_09165 ENOG41082YX Transcriptional regulator, arsr family HFZ78_09175 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HFZ78_09190 ENOG4108W15 Protein of unknown function (DUF1456) HFZ78_09195 ENOG4105CNG UPF0061 protein HFZ78_09205 ENOG4107HP6 Transcriptional regulator HFZ78_09215 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HFZ78_09220 ENOG4105CY2 Citrate transporter HFZ78_09230 ENOG4105K56 Transcriptional regulator HFZ78_09235 ENOG4108V06 Glutathione peroxidase HFZ78_09255 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HFZ78_09260 ENOG4105DUX Transporter HFZ78_09265 ENOG4107TXC Transcriptional regulator HFZ78_09270 ENOG4105C3U ABC transporter HFZ78_09275 ENOG4108JQ7 (ABC) transporter HFZ78_09280 ENOG4105DEF Extracellular solute-binding protein, family 5 HFZ78_09285 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HFZ78_09290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HFZ78_09295 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HFZ78_09300 ENOG4105FF2 Type I DHQase HFZ78_09310 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HFZ78_09315 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HFZ78_09320 ENOG4105CAS nag kinase HFZ78_09325 ENOG4105C8Y Acetylornithine aminotransferase HFZ78_09330 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HFZ78_09335 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HFZ78_09340 ENOG4105DBV ornithine carbamoyltransferase HFZ78_09345 ENOG4105CDH Citrulline--aspartate ligase HFZ78_09350 ENOG4105CH7 arginosuccinase HFZ78_09355 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HFZ78_09370 ENOG4105D6E homoserine dehydrogenase HFZ78_09385 ENOG4105ECP epimerase HFZ78_09390 ENOG410902V Modulates RecA activity (By similarity) HFZ78_09395 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HFZ78_09405 ENOG4105XHU Acid-soluble spore protein K HFZ78_09415 ENOG41067AE Membrane-bound metal-dependent hydrolase HFZ78_09420 ENOG4105CEN a g-specific adenine glycosylase HFZ78_09425 ENOG4106BXE HFZ78_09430 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HFZ78_09450 ENOG4105BZ1 (ABC) transporter HFZ78_09455 ENOG4107NBY Membrane HFZ78_09460 ENOG4105CBC glutamate synthase HFZ78_09465 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HFZ78_09470 ENOG4108IUW ABC transporter HFZ78_09490 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HFZ78_09495 ENOG4105G5W regulator Fur family HFZ78_09500 ENOG4105TUA UPF0295 protein HFZ78_09615 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HFZ78_09625 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HFZ78_09630 ENOG4108DBC nitroreductase HFZ78_09635 ENOG4105CYN Serine protein kinase HFZ78_09645 ENOG4106N3A copper homeostasis protein cutc HFZ78_09670 ENOG4105CI1 PTS System HFZ78_09675 ENOG4105CE4 GlcNAc 6-P deacetylase HFZ78_09680 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HFZ78_09690 ENOG4108SU4 UPF0309 protein HFZ78_09695 ENOG4105K4I Scp-like extracellular HFZ78_09700 ENOG4105BZU Histidine kinase HFZ78_09715 ENOG4105CT4 transporter HFZ78_09720 ENOG4105CT4 transporter HFZ78_09725 ENOG4105E2R ROK family HFZ78_09730 ENOG4105D2H Uronic isomerase HFZ78_09735 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HFZ78_09750 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HFZ78_09765 ENOG4105E2R ROK family HFZ78_09775 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HFZ78_09785 ENOG4105CMG Carbohydrate kinase HFZ78_09790 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase HFZ78_09795 ENOG4105C8M UPF0272 protein HFZ78_09805 ENOG4105CV1 Transketolase (EC 2.2.1.1) HFZ78_09815 ENOG4107R3E Citrate transporter HFZ78_09820 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HFZ78_09825 ENOG4107WA4 MmpL domain-containing protein HFZ78_09830 ENOG4107RHR regulatoR HFZ78_09835 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HFZ78_09875 ENOG4105C26 Dehydrogenase HFZ78_09900 ENOG4105II7 pyrroline-5-carboxylate reductase HFZ78_09905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HFZ78_09915 ENOG4107QJZ Glycosyl transferase, family 2 HFZ78_09925 ENOG4108JYZ YitT family HFZ78_09930 ENOG4105CJ3 phosphate transporter HFZ78_09935 ENOG4107GRR phosphate transport regulator HFZ78_09940 ENOG4107BMA Transglycosylase associated protein HFZ78_09945 ENOG4108YBP pseudouridine synthase HFZ78_09970 ENOG4105ED1 spovr family HFZ78_09975 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HFZ78_09980 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HFZ78_09985 ENOG4108UX3 '-nucleotidase HFZ78_10010 ENOG4107R8N Glycosyl transferase, family 2 HFZ78_10030 ENOG4105C6Y Udp-glucose 6-dehydrogenase HFZ78_10035 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HFZ78_10040 ENOG4105DCF alanine dehydrogenase HFZ78_10045 ENOG4108K8K Transcriptional regulator HFZ78_10050 ENOG4105C85 amino acid HFZ78_10055 ENOG4105EYF MMPL domain protein HFZ78_10060 ENOG4105MKU Transcriptional regulator HFZ78_10065 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HFZ78_10075 ENOG4106BRA Membrane HFZ78_10090 ENOG4105C37 (CBS) domain HFZ78_10095 ENOG4105C37 (CBS) domain HFZ78_10105 ENOG4105BZU Histidine kinase HFZ78_10130 ENOG4105BZ4 penicillin-binding protein HFZ78_10135 ENOG4105BZ1 (ABC) transporter HFZ78_10140 ENOG4105BZ1 (ABC) transporter HFZ78_10150 ENOG4105C9Q fumarate hydratase class II HFZ78_10190 ENOG410839P HFZ78_10205 ENOG4105WZB UPF0342 protein HFZ78_10215 ENOG4105CGU Enoyl-CoA hydratase HFZ78_10225 ENOG4108IUX (ABC) transporter HFZ78_10230 ENOG4105RHA ABC transporter, permease HFZ78_10235 ENOG4107VRP DNA repair exonuclease HFZ78_10240 ENOG4106D4I domain protein HFZ78_10245 ENOG4105EQI Metal Dependent Phosphohydrolase HFZ78_10255 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HFZ78_10280 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) HFZ78_10290 ENOG4105NBU tryptophan transport protein HFZ78_10295 ENOG4105K59 histidine triad (HIT) protein HFZ78_10330 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HFZ78_10335 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HFZ78_10340 ENOG4105C1Q protoporphyrinogen oxidase HFZ78_10345 ENOG4105ECB domain protein HFZ78_10350 ENOG4108RQ5 Beta-lactamase domain-containing protein HFZ78_10355 ENOG4105DF9 Lipoate-protein, ligase HFZ78_10360 ENOG4105CEY Amp-dependent synthetase and ligase HFZ78_10365 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HFZ78_10375 ENOG4105XVF Competence transcription factor HFZ78_10380 ENOG41060YP HFZ78_10385 ENOG4108RCF TRANSCRIPTIONal HFZ78_10490 ENOG4105ERH Fumarylacetoacetate hydrolase HFZ78_10495 ENOG4105YHS UPF0344 protein HFZ78_10515 ENOG4105D06 uba thif-type nad fad binding protein HFZ78_10525 ENOG4105CAQ asparagine synthetase HFZ78_10530 ENOG4105CG3 alpha amylase, catalytic region HFZ78_10535 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HFZ78_10540 ENOG4108VPT UPF0234 protein HFZ78_10545 ENOG4105QNR S1 RNA binding domain protein HFZ78_10555 ENOG4105EPR degv family HFZ78_10560 ENOG4107AYK membrAne HFZ78_10565 ENOG41073B9 HFZ78_10575 ENOG4108KP7 hydrolase HFZ78_10580 ENOG4105VG1 fes assembly suf system protein HFZ78_10590 ENOG4107V6Q Cyclic nucleotide-binding domain HFZ78_10595 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HFZ78_10600 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HFZ78_10605 ENOG4105CVM Molybdenum cofactor synthesis domain protein HFZ78_10610 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HFZ78_10620 ENOG4107V6Q Cyclic nucleotide-binding domain HFZ78_10630 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HFZ78_10650 ENOG4107RMD Basic membrane lipoprotein HFZ78_10660 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HFZ78_10665 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HFZ78_10675 ENOG4105C3U ABC transporter HFZ78_10680 ENOG4108JQ7 (ABC) transporter HFZ78_10685 ENOG4105DEF Extracellular solute-binding protein, family 5 HFZ78_10695 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HFZ78_10700 ENOG4108KU1 UPF0736 protein HFZ78_10705 ENOG4105C31 Tryptophanyl-tRNA synthetase HFZ78_10715 ENOG4108J59 Extracellular solute-binding protein, family 5 HFZ78_10720 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HFZ78_10725 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HFZ78_10735 ENOG4108JQ7 (ABC) transporter HFZ78_10745 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HFZ78_10750 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HFZ78_10755 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HFZ78_10765 ENOG4105DPN Oligoendopeptidase f HFZ78_10770 ENOG4105T58 Dithiol-disulfide isomerase HFZ78_10775 ENOG4108Z18 K06886 hemoglobin HFZ78_10780 ENOG4105MIX Adenylate cyclase HFZ78_10800 ENOG4105EMS pseudouridine synthase HFZ78_10805 ENOG4107S1Q Phosphatase HFZ78_10815 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HFZ78_10845 ENOG41090VF Stage v sporulation protein ac HFZ78_10850 ENOG4105CZ3 stage V sporulation protein ad HFZ78_10870 ENOG4105ENA helicase HFZ78_10900 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HFZ78_10910 ENOG4105D6N CoA-transferase, subunit a HFZ78_10920 ENOG4105CHU acetyl-coa acetyltransferase HFZ78_10925 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HFZ78_10930 ENOG4108JPW Aminotransferase HFZ78_10945 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HFZ78_10950 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HFZ78_10960 ENOG4108IQI permease HFZ78_10965 ENOG4105D03 DNA-3-methyladenine glycosylase II HFZ78_10970 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HFZ78_10980 ENOG4105NAA Cytochrome C oxidase, subunit II HFZ78_10985 ENOG4107RQ2 Cytochrome c oxidase, subunit I HFZ78_11000 ENOG4108V0P LemA family HFZ78_11010 ENOG4105C02 permease HFZ78_11015 ENOG4105EP8 Glycosyl Hydrolase Family 88 HFZ78_11040 ENOG4107XVH Transcriptional regulator HFZ78_11045 ENOG4105MU9 integral membrane protein HFZ78_11050 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HFZ78_11065 ENOG4105C2F Histidine kinase HFZ78_11080 ENOG4105DKQ ROK family HFZ78_11085 ENOG4105E70 isomerase HFZ78_11090 ENOG4105CE4 GlcNAc 6-P deacetylase HFZ78_11095 ENOG4105DE4 1-phosphofructokinase HFZ78_11100 ENOG4105D2M Aldolase HFZ78_11105 ENOG4108UHU Aldolase HFZ78_11115 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) HFZ78_11120 ENOG4105CHR reductase HFZ78_11145 ENOG4105CT4 transporter HFZ78_11195 ENOG4108JYZ YitT family HFZ78_11200 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HFZ78_11245 ENOG4108ZGX Histidine kinase HFZ78_11250 ENOG4108S01 response regulator HFZ78_11255 ENOG4105C2C drug resistance transporter, Bcr CflA HFZ78_11260 ENOG4108MUZ hydrolase HFZ78_11270 ENOG41062D9 Histidine kinase HFZ78_11275 ENOG4105CRQ synthase (Component I) HFZ78_11280 ENOG4105DDQ anthranilate synthase HFZ78_11285 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HFZ78_11290 ENOG410756H nucleotidyltransferase HFZ78_11295 ENOG4108T5E Copper resistance protein HFZ78_11310 ENOG4105CHM Aminotransferase HFZ78_11325 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HFZ78_11345 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HFZ78_11355 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HFZ78_11375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HFZ78_11385 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HFZ78_11395 ENOG4108WZW RNA polymerase sigma HFZ78_11405 ENOG410681C small acid-soluble spore protein HFZ78_11430 ENOG4105DAA L-lactate HFZ78_11435 ENOG4105JXH GntR family transcriptional regulator HFZ78_11440 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HFZ78_11445 ENOG4107QR9 Iron-sulfur cluster binding protein HFZ78_11450 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HFZ78_11460 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HFZ78_11470 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HFZ78_11475 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HFZ78_11485 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HFZ78_11490 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HFZ78_11495 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HFZ78_11500 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HFZ78_11515 ENOG4105BZJ Electron transfer flavoprotein HFZ78_11520 ENOG4105C10 Electron transfer flavoprotein HFZ78_11525 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HFZ78_11540 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HFZ78_11545 ENOG4105EU0 Major facilitator Superfamily HFZ78_11550 ENOG41090MY MarR family Transcriptional regulator HFZ78_11565 ENOG4108K88 Membrane HFZ78_11585 ENOG4105KRI phosphocarrier protein (HPr HFZ78_11590 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HFZ78_11605 ENOG4108KEZ Dehydrogenase HFZ78_11615 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HFZ78_11625 ENOG4105CHM Aminotransferase HFZ78_11635 ENOG4105UIN HFZ78_11650 ENOG4105EPM Diguanylate phosphodiesterase HFZ78_11655 ENOG4107IN1 Protein of unknown function (DUF1797) HFZ78_11665 ENOG4105C0R drug resistance transporter emrb qaca subfamily HFZ78_11675 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HFZ78_11680 ENOG4105CH2 amidohydrolase HFZ78_11685 ENOG4105D3R alkyl hydroperoxide reductase HFZ78_11690 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HFZ78_11700 ENOG4107ZYR domain protein HFZ78_11705 ENOG4105CN5 Metallo-Beta-Lactamase HFZ78_11710 ENOG4106148 UPF0356 protein HFZ78_11715 ENOG4108X4Q Hydrolase HFZ78_11770 ENOG4105CXN decarboxylase HFZ78_11775 ENOG4105EA8 2-Nitropropane dioxygenase HFZ78_11780 ENOG4105WBI UPF0223 protein HFZ78_11785 ENOG4108WQ8 UPF0637 protein HFZ78_11795 ENOG4105ECY inositol monophosphatase HFZ78_11805 ENOG4105CI3 gtp-binding protein typa HFZ78_11810 ENOG4105QA2 HFZ78_11835 ENOG4108IAB Phoh family HFZ78_11845 ENOG4105ZPI UPF0358 protein HFZ78_11850 ENOG4105CNI cell division protein FtsW HFZ78_11855 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HFZ78_11860 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HFZ78_11865 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HFZ78_11905 ENOG41080XQ Signal transduction protein with cbs domains HFZ78_11910 ENOG4106UY4 Inherit from COG: Scp-like extracellular HFZ78_11955 ENOG4106H78 methyltransferase HFZ78_11960 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HFZ78_11965 ENOG4105H20 Sporulation integral membrane protein YlbJ HFZ78_11970 ENOG4105D78 K07001 NTE family protein HFZ78_11975 ENOG41063PX domain protein HFZ78_11980 ENOG4105CDE UPF0348 protein HFZ78_11985 ENOG4105KNH Nucleic acid-binding protein HFZ78_11990 ENOG41067VY 50S ribosomal protein L32 HFZ78_11995 ENOG4105E39 Enoyl-CoA hydratase HFZ78_12010 ENOG4107QX3 carboxylase HFZ78_12025 ENOG41074B2 UPF0747 protein HFZ78_12030 ENOG4108V6E Cell division protein mraZ HFZ78_12040 ENOG41068DC Essential cell division protein (By similarity) HFZ78_12045 ENOG4105CJN penicillin-binding protein HFZ78_12050 ENOG4105CJN penicillin-binding protein HFZ78_12055 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HFZ78_12065 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HFZ78_12070 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HFZ78_12075 ENOG4105CNI cell division protein FtsW HFZ78_12080 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HFZ78_12085 ENOG4105D4A Cell wall formation (By similarity) HFZ78_12090 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HFZ78_12095 ENOG4108R2U division initiation protein HFZ78_12105 ENOG4105K67 small basic protein HFZ78_12110 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HFZ78_12115 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HFZ78_12120 ENOG4108AWX Sporulation factor SpoIIGA HFZ78_12125 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HFZ78_12135 ENOG4105WR5 sporulation protein, YlmC YmxH family HFZ78_12140 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HFZ78_12145 ENOG4105DFA alanine racemase domain protein HFZ78_12150 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HFZ78_12155 ENOG41067XK integral membrane protein HFZ78_12160 ENOG4105DBK s4 domain protein HFZ78_12170 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HFZ78_12185 ENOG4105C34 Pseudouridine synthase HFZ78_12190 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HFZ78_12200 ENOG4105CXT aspartate transcarbamylase HFZ78_12215 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HFZ78_12225 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HFZ78_12230 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HFZ78_12250 ENOG4105DSJ YicC domain protein HFZ78_12255 ENOG4105KC4 UPF0296 protein HFZ78_12260 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HFZ78_12265 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HFZ78_12270 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HFZ78_12275 ENOG4105C25 Primosomal protein n' HFZ78_12290 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HFZ78_12295 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HFZ78_12300 ENOG4108ZF3 Phosphatase HFZ78_12305 ENOG4105D9P serine threonine protein kinase HFZ78_12310 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HFZ78_12315 ENOG4105DJV ribulose-phosphate 3-epimerase HFZ78_12320 ENOG4105FJ0 thiamine HFZ78_12330 ENOG4105VB9 50S ribosomal protein l28 HFZ78_12335 ENOG4108ZAA Alkaline-shock protein HFZ78_12340 ENOG4105DP4 dak2 domain fusion protein ylov HFZ78_12345 ENOG4105CB5 ATP-dependent DNA helicase recG HFZ78_12350 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HFZ78_12355 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HFZ78_12360 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HFZ78_12365 ENOG4105CHR reductase HFZ78_12380 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HFZ78_12385 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HFZ78_12390 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HFZ78_12400 ENOG4105K5M 30s ribosomal protein S16 HFZ78_12405 ENOG4105VB6 UPF0109 protein HFZ78_12415 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HFZ78_12420 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HFZ78_12435 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HFZ78_12445 ENOG4105EJQ L-serine dehydratase HFZ78_12460 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HFZ78_12465 ENOG4105C79 DNA protecting protein DprA HFZ78_12470 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HFZ78_12475 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HFZ78_12480 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HFZ78_12485 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HFZ78_12490 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) HFZ78_12495 ENOG4105CE9 30S ribosomal protein S2 HFZ78_12505 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HFZ78_12510 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HFZ78_12515 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HFZ78_12520 ENOG4105KNE Phosphatidate cytidylyltransferase HFZ78_12530 ENOG4105DZP Membrane-associated zinc metalloprotease HFZ78_12535 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HFZ78_12540 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HFZ78_12545 ENOG4105CHV Transcription elongation factor NusA HFZ78_12550 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HFZ78_12555 ENOG4105VHM ribosomal protein HFZ78_12560 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HFZ78_12565 ENOG4105W7A Protein of unknown function (DUF503) HFZ78_12575 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HFZ78_12580 ENOG4105DTN riboflavin biosynthesis protein ribF HFZ78_12585 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HFZ78_12590 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HFZ78_12600 ENOG4105C1V Peptidase, M16 HFZ78_12610 ENOG4105E35 Dipicolinate synthase subunit A HFZ78_12615 ENOG4108S0H Dipicolinic acid synthetase, b subunit HFZ78_12620 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HFZ78_12630 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HFZ78_12640 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HFZ78_12650 ENOG4105CNU cell division protein FtsK HFZ78_12655 ENOG4105FDP GntR family transcriptional regulator HFZ78_12660 ENOG4105DIH basic membrane HFZ78_12665 ENOG4108JQ9 ABC transporter HFZ78_12670 ENOG4105UIB (ABC) transporter HFZ78_12690 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HFZ78_12695 ENOG4105XZV Protein of unknown function (DUF3243) HFZ78_12710 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HFZ78_12715 ENOG4105CEV competence damage-inducible protein HFZ78_12730 ENOG4105D48 metallophosphoesterase HFZ78_12735 ENOG4105MCT stage V sporulation protein S HFZ78_12740 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HFZ78_12745 ENOG4105DQU oxidoreductase, subunit beta HFZ78_12750 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HFZ78_12770 ENOG41068WN HFZ78_12790 ENOG4105CHR reductase HFZ78_12795 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HFZ78_12805 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HFZ78_12870 ENOG4107EFR Flavocytochrome c HFZ78_12875 ENOG4108KC1 acyl-Coa dehydrogenase HFZ78_12880 ENOG4108KC1 acyl-Coa dehydrogenase HFZ78_12885 ENOG4105DTN riboflavin biosynthesis protein ribF HFZ78_12895 ENOG4107EFR Flavocytochrome c HFZ78_12925 ENOG4105BZJ Electron transfer flavoprotein HFZ78_12930 ENOG4105C10 Electron transfer flavoprotein HFZ78_12935 ENOG4105DKW ABC transporter HFZ78_12950 ENOG4105C2F Histidine kinase HFZ78_12960 ENOG4105DFW ABC transporter HFZ78_12970 ENOG4108HWW ABC transporter HFZ78_12985 ENOG4108IPJ Membrane HFZ78_12990 ENOG4105DET Rhamnulokinase HFZ78_12995 ENOG4105DKG l-rhamnose isomerase HFZ78_13000 ENOG4105E98 transcriptional regulator DeoR family HFZ78_13005 ENOG4105DSG hydrolase family 43 HFZ78_13015 ENOG4105CK5 oxidoreductase HFZ78_13030 ENOG4105FQP Beta-lactamase HFZ78_13035 ENOG4105C2F Histidine kinase HFZ78_13040 ENOG41075H3 AraC family transcriptional regulator HFZ78_13055 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HFZ78_13060 ENOG4105MU9 integral membrane protein HFZ78_13085 ENOG4106HBX Transcriptional Regulator AraC Family HFZ78_13095 ENOG4105ETE Transcriptional regulator (LacI family HFZ78_13105 ENOG4108HHA Transketolase HFZ78_13110 ENOG4108IUS Transketolase HFZ78_13115 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HFZ78_13130 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HFZ78_13135 ENOG4105C7S Dehydrogenase HFZ78_13140 ENOG4107XVH Transcriptional regulator HFZ78_13150 ENOG4105DUM transcriptional regulator, lysR family HFZ78_13155 ENOG4107RSM transcriptional regulator HFZ78_13170 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HFZ78_13205 ENOG4105CHJ isochorismatase hydrolase HFZ78_13225 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HFZ78_13235 ENOG4105FBA Phospholipase Carboxylesterase HFZ78_13255 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HFZ78_13275 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HFZ78_13280 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HFZ78_13290 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HFZ78_13295 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HFZ78_13300 ENOG4106F1P AAA ATPase, central domain protein HFZ78_13305 ENOG4105EN6 Membrane HFZ78_13310 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HFZ78_13320 ENOG4105KV4 Transcriptional regulator HFZ78_13325 ENOG4105C5F glutamine synthetase HFZ78_13335 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HFZ78_13345 ENOG4108SVB resolvase HFZ78_13350 ENOG4105VPS UPF0291 protein HFZ78_13370 ENOG4105BZ1 (ABC) transporter HFZ78_13375 ENOG4105BZ1 (ABC) transporter HFZ78_13385 ENOG4107QIV Cytochrome c biogenesis protein HFZ78_13405 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HFZ78_13465 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HFZ78_13470 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC HFZ78_13510 ENOG4105VTR Integrase HFZ78_13555 ENOG4108RCM Nitroreductase HFZ78_13575 ENOG4105DEN Luciferase family HFZ78_13580 ENOG4105VPS UPF0291 protein HFZ78_13585 ENOG41062ES Transcriptional regulator HFZ78_13595 ENOG4108B31 Spore germination protein HFZ78_13615 ENOG4105VEQ Cold shock protein HFZ78_13635 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HFZ78_13710 ENOG4105E1K spore germination protein HFZ78_13740 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HFZ78_13745 ENOG4108UW5 maltose o-acetyltransferase HFZ78_13760 ENOG4108HGU Histidine kinase HFZ78_13770 ENOG41082BV acetyltransferase HFZ78_13775 ENOG4108U05 Transcriptional regulator HFZ78_13780 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HFZ78_13810 ENOG4105E66 phosphoriboisomerase A HFZ78_13825 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HFZ78_13830 ENOG41090MY MarR family Transcriptional regulator HFZ78_13835 ENOG4108VGI doxx family HFZ78_13840 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HFZ78_13845 ENOG4107XWI flavin reductase domain protein, FMN-binding HFZ78_13850 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HFZ78_13855 ENOG4105FBA Phospholipase Carboxylesterase HFZ78_13885 ENOG4106P55 Transcriptional regulator HFZ78_13890 ENOG4105CEY Amp-dependent synthetase and ligase HFZ78_13895 ENOG4105C26 Dehydrogenase HFZ78_13900 ENOG4105C0A alcohol dehydrogenase HFZ78_13905 ENOG4105EUZ Beta-lactamase domain protein HFZ78_13910 ENOG4105DJB Major Facilitator Superfamily HFZ78_13930 ENOG4105E39 Enoyl-CoA hydratase HFZ78_13935 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C HFZ78_13940 ENOG4107JM4 Tetratricopeptide repeat HFZ78_13945 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HFZ78_13960 ENOG4105BZJ Electron transfer flavoprotein HFZ78_13965 ENOG4105C10 Electron transfer flavoprotein HFZ78_13970 ENOG4108QY0 Membrane HFZ78_13980 ENOG4105ST3 Transcriptional regulator HFZ78_13985 ENOG4105C0R drug resistance transporter emrb qaca subfamily HFZ78_14005 ENOG4105C2F Histidine kinase HFZ78_14010 ENOG4108VAC response regulator HFZ78_14015 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HFZ78_14025 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HFZ78_14030 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HFZ78_14035 ENOG4105C2J ABC transporter HFZ78_14040 ENOG4107R9N ABC transporter HFZ78_14045 ENOG41062B0 ABC transporter, permease HFZ78_14050 ENOG4108J53 cell adhesion domain-containing protein HFZ78_14105 ENOG4108VXD carboxy-peptidase HFZ78_14120 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HFZ78_14145 ENOG4105DND Transcriptional regulator HFZ78_14155 ENOG4105DUM transcriptional regulator, lysR family HFZ78_14160 ENOG4105CEY Amp-dependent synthetase and ligase HFZ78_14170 ENOG4105DJB Major Facilitator Superfamily HFZ78_14205 ENOG4105DJB Major Facilitator Superfamily HFZ78_14215 ENOG4105D6N CoA-transferase, subunit a HFZ78_14220 ENOG4108IIH CoA-transferase subunit B HFZ78_14230 ENOG4108R85 Short chain dehydrogenase HFZ78_14250 ENOG4107RSM transcriptional regulator HFZ78_14265 ENOG4105CEY Amp-dependent synthetase and ligase HFZ78_14290 ENOG4105DJB Major Facilitator Superfamily HFZ78_14310 ENOG4108R85 Short chain dehydrogenase HFZ78_14320 ENOG4108W6C Dehydrogenase HFZ78_14325 ENOG4105C1G acyl-Coa dehydrogenase HFZ78_14330 ENOG410900P UPF0336 protein HFZ78_14340 ENOG4105BZJ Electron transfer flavoprotein HFZ78_14345 ENOG4105C10 Electron transfer flavoprotein HFZ78_14350 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HFZ78_14360 ENOG4108HNZ carboxyl transferase HFZ78_14370 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class HFZ78_14375 ENOG4105BZU Histidine kinase HFZ78_14395 ENOG4105D5P Methylmalonyl-coA mutase HFZ78_14400 ENOG4105CHU acetyl-coa acetyltransferase HFZ78_14455 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HFZ78_14485 ENOG4105C1G acyl-Coa dehydrogenase HFZ78_14490 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HFZ78_14495 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HFZ78_14500 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HFZ78_14505 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HFZ78_14510 ENOG4105E39 Enoyl-CoA hydratase HFZ78_14515 ENOG4107QX3 carboxylase HFZ78_14520 ENOG4105D6N CoA-transferase, subunit a HFZ78_14525 ENOG4108IIH CoA-transferase subunit B HFZ78_14530 ENOG4108VX5 3-methyladenine DNA glycosylase HFZ78_14545 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HFZ78_14550 ENOG4105CMD Transcriptional regulator, GntR family HFZ78_14560 ENOG4105D98 threonine synthase HFZ78_14625 ENOG4105C2F Histidine kinase HFZ78_14630 ENOG4105EQD regulatoR HFZ78_14640 ENOG4105C85 amino acid HFZ78_14645 ENOG4107RGD Major Facilitator superfamily HFZ78_14660 ENOG4105VZJ PTS System HFZ78_14665 ENOG4105CK1 PTS System HFZ78_14670 ENOG4105F8D glycoside hydrolase family 4 HFZ78_14675 ENOG4105VCP PTS System HFZ78_14705 ENOG4108IMY Transcriptional regulator HFZ78_14710 ENOG4105HDK L-asparaginase HFZ78_14720 ENOG4107TDE lipolytic protein G-D-S-L family HFZ78_14730 ENOG4108MRH transcriptional regulatory protein HFZ78_14735 ENOG4105D4T Citrate transporter HFZ78_14760 ENOG4105D2S major facilitator superfamily HFZ78_14765 ENOG4105EFA 4-hydroxyphenylacetate HFZ78_14770 ENOG4105U1N riboflavin HFZ78_14775 ENOG4107V0Z fmn reductase HFZ78_14800 ENOG4105IKQ hydratase HFZ78_14810 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HFZ78_14815 ENOG4105C85 amino acid HFZ78_14820 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HFZ78_14825 ENOG4108PXI ErfK YbiS YcfS YnhG HFZ78_14850 ENOG4105F6S Spore photoproduct lyase HFZ78_14855 ENOG4105C0R drug resistance transporter emrb qaca subfamily HFZ78_14860 ENOG41067SE Tetr family transcriptional regulator HFZ78_14880 ENOG4105E1K spore germination protein HFZ78_14905 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HFZ78_14920 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HFZ78_14925 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HFZ78_14930 ENOG4108JYZ YitT family HFZ78_14935 ENOG4105DXB Major Facilitator superfamily HFZ78_14940 ENOG41061AU MarR family Transcriptional regulator HFZ78_14945 ENOG4108IJ0 Aspartate ammonia-lyase HFZ78_14955 ENOG41073R8 VanW family HFZ78_14965 ENOG4108JUB Transcriptional regulator HFZ78_14970 ENOG4108IQI permease HFZ78_15010 ENOG4105CHH sulfate transporter HFZ78_15020 ENOG4105VEQ Cold shock protein HFZ78_15030 ENOG4105EYH Exonuclease HFZ78_15045 ENOG4106UIA HFZ78_15055 ENOG4105EM7 Selenocysteine-specific translation elongation factor HFZ78_15060 ENOG4106FN3 tellurium resistance protein HFZ78_15065 ENOG4105EYF MMPL domain protein HFZ78_15070 ENOG41067TZ transcriptional regulator, MarR family HFZ78_15080 ENOG4108STX response regulator HFZ78_15085 ENOG4105US7 Histidine kinase HFZ78_15095 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HFZ78_15110 ENOG4105MUA Resistance protein HFZ78_15135 ENOG4105CJ1 ABC, transporter HFZ78_15140 ENOG4108TU7 Inherit from COG: (ABC) transporter HFZ78_15155 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HFZ78_15160 ENOG4105DER m42 family HFZ78_15170 ENOG4105D7N magnesium and cobalt transport protein CorA HFZ78_15180 ENOG4105K4H Nlp p60 protein HFZ78_15185 ENOG41080BT SNARE associated Golgi HFZ78_15200 ENOG4108UT2 hemolysin iii HFZ78_15205 ENOG41080V3 Major Facilitator superfamily HFZ78_15210 ENOG4105XRQ Xanthine dehydrogenase accessory factor HFZ78_15220 ENOG4108XHQ (2Fe-2S)-binding domain protein HFZ78_15225 ENOG4107RF6 penicillin-binding protein HFZ78_15230 ENOG4105CTD carboxy-peptidase HFZ78_15235 ENOG4107TS3 membrane protein, TerC HFZ78_15240 ENOG410841Q phosphoesterase PA-phosphatase related protein HFZ78_15245 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HFZ78_15250 ENOG41060D1 Quinol oxidase HFZ78_15255 ENOG4105CCU oxidase (Subunit III) HFZ78_15260 ENOG4105BZ9 Cytochrome C oxidase, subunit I HFZ78_15265 ENOG4105E2S oxidase) subunit II HFZ78_15295 ENOG4105VEQ Cold shock protein HFZ78_15320 ENOG4108R6K riboflavin synthase, subunit alpha HFZ78_15325 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HFZ78_15330 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HFZ78_15335 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HFZ78_15340 ENOG4105EHG Permease protein HFZ78_15345 ENOG4105E0A ABC, transporter HFZ78_15350 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HFZ78_15355 ENOG4107QZB decarboxylase HFZ78_15360 ENOG4108YZT Adenosylcobinamide kinase HFZ78_15365 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HFZ78_15370 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HFZ78_15385 ENOG4108WBT adenosyltransferase HFZ78_15400 ENOG4105BZ4 penicillin-binding protein HFZ78_15405 ENOG4105C19 ABC transporter HFZ78_15410 ENOG4107R34 abc transporter permease protein HFZ78_15420 ENOG4105E5W Transporter HFZ78_15435 ENOG4105E1K spore germination protein HFZ78_15455 ENOG4105BZU Histidine kinase HFZ78_15460 ENOG4107TCE N-acetyltransferase HFZ78_15480 ENOG4105C1G acyl-Coa dehydrogenase HFZ78_15485 ENOG4105CHR reductase HFZ78_15505 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HFZ78_15515 ENOG4105CHU acetyl-coa acetyltransferase HFZ78_15520 ENOG4105CEY Amp-dependent synthetase and ligase HFZ78_15525 ENOG4105C32 Amino acid ABC transporter (Permease) HFZ78_15530 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HFZ78_15535 ENOG4105C0Z ABC transporter HFZ78_15540 ENOG4108IV0 ABC, transporter HFZ78_15550 ENOG41069FQ Metallo-beta-lactamase superfamily HFZ78_15555 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta HFZ78_15560 ENOG4105C26 Dehydrogenase HFZ78_15565 ENOG4105C0A alcohol dehydrogenase HFZ78_15580 ENOG4105DTE Xanthine uracil vitamin C permease HFZ78_15590 ENOG410667J hydrolase HFZ78_15605 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HFZ78_15630 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HFZ78_15640 ENOG4107RN3 metallophosphoesterase HFZ78_15660 ENOG4105DEU major facilitator superfamily HFZ78_15675 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HFZ78_15690 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HFZ78_15695 ENOG4106YYS transcriptional regulatory protein HFZ78_15715 ENOG4105PKS Excinuclease abc c subunit domain protein HFZ78_15720 ENOG4106FN3 tellurium resistance protein HFZ78_15740 ENOG4105CGP Urocanate hydratase HFZ78_15745 ENOG4105CI2 imidazolone-5-propionate hydrolase HFZ78_15750 ENOG4108903 Formimidoylglutamase HFZ78_15760 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HFZ78_15770 ENOG4105BZU Histidine kinase HFZ78_15775 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HFZ78_15785 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HFZ78_15810 ENOG4107ETC gas vesicle protein HFZ78_15815 ENOG4108XNA Gas vesicle HFZ78_15850 ENOG4107QJT sodium dicarboxylate symporter HFZ78_15855 ENOG4108MRH transcriptional regulatory protein HFZ78_15870 ENOG4105DWF phosphomethylpyrimidine kinase HFZ78_15890 ENOG4105ETU transcriptional activator (TenA HFZ78_15900 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HFZ78_15930 ENOG4105VEQ Cold shock protein HFZ78_15940 ENOG4105CHH sulfate transporter HFZ78_15950 ENOG41085FC arsR family transcriptional regulator HFZ78_15955 ENOG4107QMU Mate efflux family protein HFZ78_15980 ENOG4105C5Y PTS System HFZ78_15995 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HFZ78_16000 ENOG4105I4A GCN5-related N-acetyltransferase HFZ78_16005 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HFZ78_16010 ENOG4105KAC Antibiotic biosynthesis monooxygenase HFZ78_16035 ENOG4108ZYE Transcriptional regulator HFZ78_16040 ENOG4105KTB nuclear export factor GLE1 HFZ78_16050 ENOG4108KK1 membrane protein AbrB duplication HFZ78_16075 ENOG4107RVV histidinol phosphate phosphatase, hisj family HFZ78_16085 ENOG4105Z8B NlpC/P60 family HFZ78_16100 ENOG4105E8R UPF0173 metal-dependent hydrolase HFZ78_16105 ENOG4105C85 amino acid HFZ78_16125 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HFZ78_16130 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HFZ78_16135 ENOG4105CPC Aldo Keto reductase HFZ78_16145 ENOG4107U9B transcriptional regulator HFZ78_16150 ENOG4108UMN azlc family HFZ78_16155 ENOG4105KMT branched-chain amino acid HFZ78_16165 ENOG4105C5W Aldolase HFZ78_16170 ENOG4108JQ1 Dehydrogenase HFZ78_16175 ENOG4108UZX fmn reductase HFZ78_16220 ENOG4105C0X amino acid HFZ78_16225 ENOG4105F04 LysR family Transcriptional regulator HFZ78_16235 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HFZ78_16280 ENOG4105ETE Transcriptional regulator (LacI family HFZ78_16285 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HFZ78_16290 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HFZ78_16295 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HFZ78_16305 ENOG4108VEU Thiamine monophosphate synthase HFZ78_16310 ENOG41080HI glycine oxidase HFZ78_16320 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HFZ78_16325 ENOG4105D06 uba thif-type nad fad binding protein HFZ78_16340 ENOG4107ZTW SNARE associated Golgi HFZ78_16365 ENOG4107TSN permease HFZ78_16395 ENOG4105VMP Transcriptional regulator HFZ78_16400 ENOG4105MKU Transcriptional regulator HFZ78_16410 ENOG4108M8W Monooxygenase HFZ78_16420 ENOG4105ECR NmrA family HFZ78_16430 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HFZ78_16440 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HFZ78_16485 ENOG41068WN HFZ78_16530 ENOG41075H3 AraC family transcriptional regulator HFZ78_16545 ENOG4108Z5V transcriptional regulator, merr family HFZ78_16550 ENOG4108UQV Membrane HFZ78_16555 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HFZ78_16590 ENOG4105EHG Permease protein HFZ78_16595 ENOG4105DQ5 transport system permease protein HFZ78_16600 ENOG4108UHE carbonic anhydrase HFZ78_16610 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HFZ78_16625 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HFZ78_16630 ENOG4105VUF Transcriptional regulator HFZ78_16635 ENOG4105DQ4 alcohol dehydrogenase HFZ78_16640 ENOG4108W5M transcriptional regulator HFZ78_16645 ENOG4105EMU Dehydrogenase HFZ78_16670 ENOG4108RWP Major Facilitator Superfamily protein HFZ78_16675 ENOG4105DTD Dehydrogenase HFZ78_16680 ENOG4105DQ4 alcohol dehydrogenase HFZ78_16690 ENOG4108UW5 maltose o-acetyltransferase HFZ78_16700 ENOG4105ST3 Transcriptional regulator HFZ78_16705 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HFZ78_16710 ENOG4108RWP Major Facilitator Superfamily protein HFZ78_16730 ENOG4106IQC argininosuccinate lyase HFZ78_16740 ENOG4108KC1 acyl-Coa dehydrogenase HFZ78_16750 ENOG4108JNI Alpha beta hydrolase HFZ78_16800 ENOG4105DQ6 Transposase HFZ78_16830 ENOG4108UW5 maltose o-acetyltransferase HFZ78_16870 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HFZ78_16885 ENOG4105ENE Histidine kinase HFZ78_16890 ENOG4108VB1 regulatoR HFZ78_16900 ENOG41075H3 AraC family transcriptional regulator HFZ78_16910 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HFZ78_16920 ENOG41063TF transcriptional regulator (AraC HFZ78_16935 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HFZ78_16945 ENOG4108NIW Leucine export protein LeuE HFZ78_16960 ENOG4105PFC Transcriptional regulator HFZ78_16980 ENOG4105E1K spore germination protein HFZ78_17010 ENOG4105ST3 Transcriptional regulator HFZ78_17025 ENOG41090E6 transcriptional regulator MERR family HFZ78_17035 ENOG410900G Protein of unknown function (DUF421) HFZ78_17075 ENOG4105CHJ isochorismatase hydrolase HFZ78_17125 ENOG41090MY MarR family Transcriptional regulator HFZ78_17145 ENOG4105C7W Xanthine dehydrogenase HFZ78_17170 ENOG4105BZU Histidine kinase HFZ78_17190 ENOG4105EUB pirin domain protein HFZ78_17195 ENOG4105KVH Transcriptional regulator HFZ78_17200 ENOG4105NAE bifunctional deaminase-reductase domain protein HFZ78_17265 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HFZ78_17270 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) HFZ78_17280 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HFZ78_17290 ENOG4108U05 Transcriptional regulator HFZ78_17295 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HFZ78_17420 ENOG41090MY MarR family Transcriptional regulator HFZ78_17425 ENOG4108VGI doxx family HFZ78_17430 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HFZ78_17435 ENOG4107XWI flavin reductase domain protein, FMN-binding HFZ78_17445 ENOG4105FBA Phospholipase Carboxylesterase HFZ78_17455 ENOG4105CS1 NAD(P)H quinone oxidoreductase HFZ78_17475 ENOG4108B31 Spore germination protein HFZ78_17525 ENOG410900G Protein of unknown function (DUF421) HFZ78_17565 ENOG4105WCN acetyltransferase HFZ78_17585 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HFZ78_17610 ENOG41080TC multidrug resistance protein HFZ78_17615 ENOG4105VRS hydrolase family 18 HFZ78_17645 ENOG4107YZX Universal stress protein HFZ78_17655 ENOG4105CHR reductase HFZ78_17670 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HFZ78_17675 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HFZ78_17680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HFZ78_17690 ENOG4108JQ7 (ABC) transporter HFZ78_17695 ENOG4107R73 Mate efflux family protein HFZ78_17715 ENOG4105E4R Precorrin-3B C17-methyltransferase HFZ78_17720 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HFZ78_17725 ENOG4108JTQ reductase HFZ78_17730 ENOG41081F0 Precorrin-8x methylmutase HFZ78_17735 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HFZ78_17740 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HFZ78_17750 ENOG4105CIA precorrin-4 C(11)-methyltransferase HFZ78_17755 ENOG4108P62 biosynthesis protein (CbiG) HFZ78_17760 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HFZ78_17765 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HFZ78_17770 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HFZ78_17775 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HFZ78_17785 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HFZ78_17790 ENOG4105JZC GHMP kinase HFZ78_17805 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HFZ78_17820 ENOG4108PJD permease HFZ78_17865 ENOG4105VPX protein, conserved in bacteria HFZ78_17870 ENOG410681U heavy metal transport detoxification protein HFZ78_17880 ENOG4105C59 p-type ATPase HFZ78_17900 ENOG4105CUB amino acid HFZ78_17925 ENOG4105R9B Major Facilitator HFZ78_17940 ENOG4105C28 cystathionine HFZ78_17945 ENOG4105D6E homoserine dehydrogenase HFZ78_17960 ENOG4107R6U sodium dicarboxylate symporter HFZ78_17985 ENOG4105KJF protein tyrosine phosphatase HFZ78_18015 ENOG4108MEK Metal-binding protein YodA HFZ78_18055 ENOG4105WDJ 50S ribosomal protein L33 HFZ78_18060 ENOG4105CKI cobalamin synthesis protein HFZ78_18070 ENOG4108PJD permease HFZ78_18075 ENOG4105DSE periplasmic solute binding protein HFZ78_18135 ENOG4105EQD regulatoR HFZ78_18160 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HFZ78_18180 ENOG41082BM Transcriptional regulator, arsr family HFZ78_18190 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) HFZ78_18195 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HFZ78_18200 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HFZ78_18215 ENOG4107K5X Membrane-bound metal-dependent hydrolase HFZ78_18245 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HFZ78_18280 ENOG4105DQ6 Transposase HFZ78_18320 ENOG4105CHU acetyl-coa acetyltransferase HFZ78_18330 ENOG4105CKI cobalamin synthesis protein HFZ78_18335 ENOG4105CKI cobalamin synthesis protein HFZ78_18340 ENOG4105WDJ 50S ribosomal protein L33 HFZ78_18350 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) HFZ78_18365 ENOG4105M3W utilization protein HFZ78_18370 ENOG4106S4J ethanolamine utilization protein EutP HFZ78_18375 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HFZ78_18380 ENOG4105CPD ethanolamine ammonia-lyase HFZ78_18385 ENOG4107FQ9 ethanolamine ammonia-lyase HFZ78_18390 ENOG4106D67 ethanolamine utilization protein HFZ78_18395 ENOG4105C0A alcohol dehydrogenase HFZ78_18400 ENOG4105KNY Microcompartments protein HFZ78_18415 ENOG4105KNY Microcompartments protein HFZ78_18420 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HFZ78_18425 ENOG4107R55 ethanolamine transporter HFZ78_18430 ENOG4105D2X ABC transporter substrate-binding protein HFZ78_18440 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HFZ78_18450 ENOG4108RE7 deoxyribonuclease HFZ78_18520 ENOG4107Y9E nuclease HFZ78_18570 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HFZ78_18615 ENOG4105C0D helicase HFZ78_18625 ENOG4105CDU Replicative dna helicase HFZ78_18650 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HFZ78_18775 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HFZ78_18790 ENOG4107QKA exodeoxyribonuclease V beta HFZ78_18805 ENOG4105ENA helicase HFZ78_18825 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HFZ78_18865 ENOG4105M4P Tetr family transcriptional regulator HFZ78_18870 ENOG4105K63 Thioredoxin HFZ78_18910 ENOG4105D17 glycoside hydrolase, family 3 domain protein HFZ78_18920 ENOG4105DND Transcriptional regulator HFZ78_18935 ENOG4105FDP GntR family transcriptional regulator HFZ78_18950 ENOG4105F38 ABC transporter, permease HFZ78_18955 ENOG4105D38 putrescine abc transporter HFZ78_18985 ENOG4105ERH Fumarylacetoacetate hydrolase HFZ78_18995 ENOG4105CBC glutamate synthase HFZ78_19000 ENOG4105BZ8 glutamate synthase HFZ78_19005 ENOG4108IFG nitrite reductase, (NAD(P)H) HFZ78_19010 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HFZ78_19015 ENOG4105TMB Formate nitrite transporter HFZ78_19025 ENOG4105C2C drug resistance transporter, Bcr CflA HFZ78_19055 ENOG4105KJF protein tyrosine phosphatase HFZ78_19065 ENOG4105T38 integral membrane protein HFZ78_19090 ENOG4105DQ6 Transposase HFZ78_19100 ENOG4105C26 Dehydrogenase HFZ78_19105 ENOG4105CK7 Sodium proline symporter HFZ78_19170 ENOG4105DTD Dehydrogenase HFZ78_19180 ENOG4105EMU Dehydrogenase HFZ78_19185 ENOG4105CF7 AraC family transcriptional regulator HFZ78_19220 ENOG4105KVH Transcriptional regulator HFZ78_19270 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HFZ78_19375 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HFZ78_19385 ENOG4105WAB arsR family transcriptional regulator HFZ78_19400 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HFZ78_19415 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HFZ78_19430 ENOG4107GFK fumarate HFZ78_19510 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HFZ78_19515 ENOG4108RWP Major Facilitator Superfamily protein HFZ78_19555 ENOG4105DE4 1-phosphofructokinase HFZ78_19560 ENOG4105DM4 PTS System HFZ78_19565 ENOG4105KRI phosphocarrier protein (HPr HFZ78_19570 ENOG4105C26 Dehydrogenase HFZ78_19575 ENOG4105CBC glutamate synthase HFZ78_19580 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HFZ78_19665 ENOG4105FUY alpha subunit HFZ78_19670 ENOG4105KRG Aromatic-ring-hydroxylating dioxygenase beta subunit HFZ78_19695 ENOG4108WAV Transcriptional regulator HFZ78_19705 ENOG4108W0I acetyltransferase HFZ78_19715 ENOG4105UNS Pfam:DUF419 HFZ78_19735 ENOG4107KM7 Heat induced stress protein YflT HFZ78_19740 ENOG4105BZU Histidine kinase HFZ78_19750 ENOG4105C5Q Transcriptional regulator HFZ78_19755 ENOG4107R37 Glutamate dehydrogenase HFZ78_19775 ENOG4105VUF Transcriptional regulator HFZ78_19780 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HFZ78_19785 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HFZ78_19790 ENOG4108Q5U germination protein, ger(x)c family HFZ78_19805 ENOG4108HRK Histidine kinase HFZ78_19810 ENOG4105DY9 regulatoR HFZ78_19815 ENOG4105FCD Major Facilitator HFZ78_19825 ENOG4105E1K spore germination protein HFZ78_19830 ENOG4108NHD germination protein HFZ78_19865 ENOG4105BZU Histidine kinase HFZ78_19900 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HFZ78_19910 ENOG41069DP small acid-soluble spore protein HFZ78_19960 ENOG4106UIA HFZ78_19995 ENOG4108YYS metal-dependent hydrolase (By similarity) HFZ78_20010 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HFZ78_20020 ENOG4105HEI LysR family (Transcriptional regulator HFZ78_20030 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HFZ78_20045 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HFZ78_20060 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HFZ78_20065 ENOG4105VUF Transcriptional regulator HFZ78_20140 ENOG4105VMP Transcriptional regulator HFZ78_20150 ENOG41080XP Cbs domain HFZ78_20165 ENOG4105BZ8 glutamate synthase HFZ78_20170 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HFZ78_20195 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HFZ78_20200 ENOG4105C26 Dehydrogenase HFZ78_20205 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HFZ78_20230 ENOG4105FBA Phospholipase Carboxylesterase HFZ78_20235 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HFZ78_20240 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HFZ78_20255 ENOG4105CE1 Ferrous iron transport protein b HFZ78_20260 ENOG4105CE1 Ferrous iron transport protein b HFZ78_20275 ENOG4108B31 Spore germination protein HFZ78_20285 ENOG4108RCF TRANSCRIPTIONal HFZ78_20305 ENOG4107TTQ Alpha beta hydrolase fold HFZ78_20320 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HFZ78_20340 ENOG4105C72 UPF0176 protein HFZ78_20345 ENOG4105DPN Oligoendopeptidase f HFZ78_20355 ENOG4107VDP teichoic acid biosynthesis HFZ78_20375 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HFZ78_20390 ENOG41085PJ rdd domain containing protein HFZ78_20410 ENOG4105C0R drug resistance transporter emrb qaca subfamily HFZ78_20420 ENOG4105ST3 Transcriptional regulator HFZ78_20430 ENOG4105C2C drug resistance transporter, Bcr CflA HFZ78_20440 ENOG4105CF7 AraC family transcriptional regulator HFZ78_20465 ENOG4105ST3 Transcriptional regulator HFZ78_20470 ENOG4105UQX Mate efflux family protein HFZ78_20530 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HFZ78_20535 ENOG4105K4P CoA-binding domain protein HFZ78_20550 ENOG4105EQD regulatoR HFZ78_20555 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HFZ78_20570 ENOG4105MI2 HFZ78_20580 ENOG4106F1P AAA ATPase, central domain protein HFZ78_20585 ENOG41067CD Small, acid-soluble spore protein Tlp HFZ78_20590 ENOG41075ZD Small, acid-soluble spore protein N HFZ78_20600 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HFZ78_20620 ENOG4108I0Z Aconitate hydratase HFZ78_20625 ENOG410746C Acid-soluble spore protein O HFZ78_20635 ENOG41076DU acid-soluble spore protein P HFZ78_20660 ENOG4105EXW epimerase dehydratase HFZ78_20665 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HFZ78_20685 ENOG4105C2W permease HFZ78_20695 ENOG4105C2W permease HFZ78_20715 ENOG4105C5H ABC transporter HFZ78_20725 ENOG4107T9Q phosphonate abc transporter HFZ78_20730 ENOG4105D5T phosphonate abc transporter HFZ78_20735 ENOG4105S7S phosphonate abc transporter HFZ78_20750 ENOG4108JYZ YitT family HFZ78_20765 ENOG4108PJD permease HFZ78_20775 ENOG4105DSE periplasmic solute binding protein HFZ78_20780 ENOG4108PJD permease HFZ78_20805 ENOG4107EF8 Glycosyl transferase (Group 1 HFZ78_20820 ENOG4105QZI O-Antigen Polymerase HFZ78_20825 ENOG4105C1B dTDP-glucose 4-6-dehydratase HFZ78_20830 ENOG4105C6Y Udp-glucose 6-dehydrogenase HFZ78_20835 ENOG4107RA4 Glycosyl transferase (Group 1 HFZ78_20840 ENOG4105PSV Polysaccharide Biosynthesis Protein HFZ78_20845 ENOG4105D3Q Sugar transferase HFZ78_20850 ENOG4105C37 (CBS) domain HFZ78_20860 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HFZ78_20915 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HFZ78_20935 ENOG4105C5Y PTS System HFZ78_20940 ENOG4105CG3 alpha amylase, catalytic region HFZ78_20945 ENOG4107414 GntR family transcriptional regulator HFZ78_20950 ENOG4108RAV Conserved protein HFZ78_20955 ENOG4105JSC dimethylmenaquinone methyltransferase HFZ78_20965 ENOG4105KD7 acetyltransferase HFZ78_21005 ENOG4108UIN ybak prolyl-trna synthetase associated region HFZ78_21015 ENOG4108UZ3 Transporter HFZ78_21020 ENOG4105CDY transcriptional regulatory protein HFZ78_21025 ENOG4105C7B Threonine dehydratase HFZ78_21030 ENOG4105EFZ amidohydrolase HFZ78_21045 ENOG4105E5Q amino acid AbC transporter HFZ78_21050 ENOG4107R0W ABC transporter HFZ78_21055 ENOG4105CDA abc transporter atp-binding protein HFZ78_21060 ENOG4108JUB Transcriptional regulator HFZ78_21070 ENOG4105D82 Glutamate dehydrogenase HFZ78_21075 ENOG4105C8Y Acetylornithine aminotransferase HFZ78_21080 ENOG4105C26 Dehydrogenase HFZ78_21085 ENOG4108Z0R Transferase HFZ78_21090 ENOG4105C0R drug resistance transporter emrb qaca subfamily HFZ78_21095 ENOG4105BZU Histidine kinase HFZ78_21100 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HFZ78_21105 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HFZ78_21110 ENOG4108IFG nitrite reductase, (NAD(P)H) HFZ78_21115 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HFZ78_21120 ENOG4108IFG nitrite reductase, (NAD(P)H) HFZ78_21145 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HFZ78_21150 ENOG4107RIQ Sulfate adenylate transferase HFZ78_21155 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HFZ78_21165 ENOG41061P3 phosphosulfolactate synthase HFZ78_21170 ENOG4107RCC Major Facilitator Superfamily HFZ78_21180 ENOG4107TSN permease HFZ78_21210 ENOG4105DDN Pentapeptide repeat-containing protein HFZ78_21215 ENOG4105C6X Major Facilitator HFZ78_21220 ENOG4107TS3 membrane protein, TerC HFZ78_21240 ENOG4105DIH basic membrane HFZ78_21245 ENOG4105DD7 kinase (PfkB family HFZ78_21250 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HFZ78_21255 ENOG4107TCE N-acetyltransferase HFZ78_21265 ENOG41061CK Antibiotic biosynthesis monooxygenase HFZ78_21280 ENOG4105CHU acetyl-coa acetyltransferase HFZ78_21285 ENOG4105CHR reductase HFZ78_21295 ENOG4105CHR reductase HFZ78_21315 ENOG4105JD4 ATPase yjob HFZ78_21330 ENOG4105JAB phenazine biosynthesis protein, phzf family HFZ78_21335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HFZ78_21345 ENOG4107XZA Glycosyl transferase family 2 HFZ78_21360 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HFZ78_21375 ENOG4105C0R drug resistance transporter emrb qaca subfamily HFZ78_21390 ENOG4108Q5U germination protein, ger(x)c family HFZ78_21395 ENOG4105E1K spore germination protein HFZ78_21410 ENOG4105BZU Histidine kinase HFZ78_21430 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HFZ78_21445 ENOG4108K4B hydrolase HFZ78_21465 ENOG4105D64 Mechanosensitive ion channel HFZ78_21490 ENOG4108NGU Transcriptional regulator HFZ78_21495 ENOG4105N14 lysine exporter protein LysE YggA HFZ78_21505 ENOG4105EA8 2-Nitropropane dioxygenase HFZ78_21540 ENOG4105N14 lysine exporter protein LysE YggA HFZ78_21560 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HFZ78_21585 ENOG4105C0R drug resistance transporter emrb qaca subfamily HFZ78_21600 ENOG41067MG lrgb family HFZ78_21605 ENOG4105VAW lrga family HFZ78_21620 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HFZ78_21625 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HFZ78_21635 ENOG41073R8 VanW family HFZ78_21640 ENOG4105TMB Formate nitrite transporter HFZ78_21645 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HFZ78_21650 ENOG4105JFG SpoIID LytB domain protein HFZ78_21665 ENOG41073TP transcriptional regulator HFZ78_21670 ENOG4105BZW Glycerate kinase HFZ78_21680 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HFZ78_21685 ENOG4105C6Z Gluconate HFZ78_21690 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HFZ78_21695 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HFZ78_21705 ENOG41060GV RNA binding s1 domain protein HFZ78_21710 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HFZ78_21715 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HFZ78_21720 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HFZ78_21730 ENOG4108UGV hypoxanthine phosphoribosyltransferase HFZ78_21735 ENOG4105C0A alcohol dehydrogenase HFZ78_21755 ENOG4105E5Q amino acid AbC transporter HFZ78_21760 ENOG4107R0W ABC transporter HFZ78_21765 ENOG4105C87 Aminotransferase class I and II HFZ78_21775 ENOG4105C5I Dehydrogenase HFZ78_21795 ENOG4108IV0 ABC, transporter HFZ78_21800 ENOG4105C0Z ABC transporter HFZ78_21805 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HFZ78_21810 ENOG4105C32 Amino acid ABC transporter (Permease) HFZ78_21830 ENOG4105EFA 4-hydroxyphenylacetate HFZ78_21850 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HFZ78_21860 ENOG4108WYP Transcriptional regulator HFZ78_21865 ENOG4105FGV Chromate HFZ78_21870 ENOG4105CAH Chromate HFZ78_21920 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) HFZ78_21930 ENOG4108ZDA Sporulation protein YyaC HFZ78_21945 ENOG4107S2E monooxygenase HFZ78_21960 ENOG4107VFR oxidoreductase HFZ78_21970 ENOG4105E1F short-chain dehydrogenase reductase HFZ78_21995 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HFZ78_22000 ENOG4105ME7 Membrane HFZ78_22005 ENOG4105C82 Malate synthase HFZ78_22045 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HFZ78_22050 ENOG4108JPW Aminotransferase HFZ78_22060 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HFZ78_22065 ENOG4105D2X ABC transporter substrate-binding protein HFZ78_22095 ENOG4105CIY formyltetrahydrofolate deformylase HFZ78_22105 ENOG4105D7K pfkb domain protein HFZ78_22110 ENOG4105UQX Mate efflux family protein HFZ78_22115 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HFZ78_22120 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HFZ78_22125 ENOG4105EA8 2-Nitropropane dioxygenase HFZ78_22165 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HFZ78_22170 ENOG4105K63 Thioredoxin HFZ78_22190 ENOG4105BZ8 glutamate synthase HFZ78_22195 ENOG4105CBC glutamate synthase HFZ78_22200 ENOG4105C5Q Transcriptional regulator HFZ78_22205 ENOG4107QNG Phosphoribosylglycinamide synthetase HFZ78_22210 ENOG4108V3E phosphoribosylglycinamide formyltransferase HFZ78_22215 ENOG4105CXB phosphoribosylaminoimidazole synthetase HFZ78_22220 ENOG4107QIK phosphoribosylformylglycinamidine synthase HFZ78_22225 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HFZ78_22230 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HFZ78_22235 ENOG4105C8V SAICAR synthetase HFZ78_22240 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HFZ78_22260 ENOG4105F4P )-transporter HFZ78_22280 ENOG4105MSY salicylate hydroxylase HFZ78_22285 ENOG4107HP6 Transcriptional regulator HFZ78_22290 ENOG4105ERH Fumarylacetoacetate hydrolase HFZ78_22305 ENOG4105CIY formyltetrahydrofolate deformylase HFZ78_22320 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HFZ78_22325 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HFZ78_22330 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HFZ78_22335 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HFZ78_22345 ENOG4105EJQ L-serine dehydratase HFZ78_22355 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HFZ78_22360 ENOG4105C85 amino acid HFZ78_22375 ENOG4105EQD regulatoR HFZ78_22380 ENOG4105C2F Histidine kinase HFZ78_22385 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HFZ78_22390 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HFZ78_22400 ENOG4108NHD germination protein HFZ78_22405 ENOG4108Q8B Spore germination protein HFZ78_22430 ENOG4108UVJ appr-1-p processing domain protein HFZ78_22440 ENOG4105T58 Dithiol-disulfide isomerase HFZ78_22445 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HFZ78_22455 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HFZ78_22465 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HFZ78_22475 ENOG4105ETS cytosine purines uracil thiamine allantoin HFZ78_22480 ENOG4105CYW agmatinase HFZ78_22540 ENOG4105CDA abc transporter atp-binding protein HFZ78_22570 ENOG4105C7F AcnD-accessory protein PrpF HFZ78_22575 ENOG4108KAM Transcriptional regulator HFZ78_22590 ENOG4108KK1 membrane protein AbrB duplication HFZ78_22600 ENOG4107EFR Flavocytochrome c HFZ78_22610 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HFZ78_22615 ENOG4105CKI cobalamin synthesis protein HFZ78_22625 ENOG4105EPU Molybdenum cofactor synthesis domain protein HFZ78_22630 ENOG4105DHP deoxycytidine triphosphate deaminase HFZ78_22635 ENOG4105WDJ 50S ribosomal protein L33 HFZ78_22645 ENOG4107QRP cobalamin biosynthesis protein CobW HFZ78_22650 ENOG4105NZG Ferredoxin HFZ78_22655 ENOG4105CKI cobalamin synthesis protein HFZ78_22660 ENOG4108UNV SUF system FeS assembly protein, NifU family HFZ78_22670 ENOG4108PJD permease HFZ78_22675 ENOG4105FDK ABC transporter HFZ78_22680 ENOG4105CC5 ABC transporter HFZ78_22685 ENOG4105DSE periplasmic solute binding protein HFZ78_22690 ENOG4105N80 Ferric uptake regulator, Fur family HFZ78_22705 ENOG4105K70 DNA-binding protein HFZ78_22725 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HFZ78_22740 ENOG4105CHU acetyl-coa acetyltransferase HFZ78_22745 ENOG4108IIH CoA-transferase subunit B HFZ78_22750 ENOG4107QP7 CoA-transferase subunit A HFZ78_22760 ENOG4108RWP Major Facilitator Superfamily protein HFZ78_22765 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HFZ78_22780 ENOG4105D17 glycoside hydrolase, family 3 domain protein HFZ78_22790 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) HFZ78_22820 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HFZ78_22825 ENOG4105DND Transcriptional regulator HFZ78_22830 ENOG4108VXD carboxy-peptidase HFZ78_22845 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HFZ78_22875 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) HFZ78_22895 ENOG4105CS1 NAD(P)H quinone oxidoreductase HFZ78_22900 ENOG4105FBA Phospholipase Carboxylesterase HFZ78_22910 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HFZ78_22915 ENOG41090MY MarR family Transcriptional regulator HFZ78_22920 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HFZ78_22930 ENOG4105VRS hydrolase family 18 HFZ78_22940 ENOG4105CS1 NAD(P)H quinone oxidoreductase HFZ78_22950 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HFZ78_22960 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HFZ78_22970 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HFZ78_22985 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HFZ78_22995 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HFZ78_23025 ENOG4105BZU Histidine kinase HFZ78_23045 ENOG4105CPF Cell wall formation (By similarity) HFZ78_23065 ENOG4108DBC nitroreductase HFZ78_23070 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HFZ78_23075 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 HFZ78_23080 ENOG4105C5Y PTS System HFZ78_23100 ENOG4105C6K Malic enzyme HFZ78_23120 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HFZ78_23125 ENOG4108HIZ formate dehydrogenase alpha subunit HFZ78_23130 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HFZ78_23140 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HFZ78_23145 ENOG4107Y9E nuclease HFZ78_23160 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HFZ78_23165 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HFZ78_23175 ENOG41083I7 UPF0145 protein HFZ78_23180 ENOG4105C1G acyl-Coa dehydrogenase HFZ78_23185 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HFZ78_23195 ENOG4105EEM helicase HFZ78_23210 ENOG4108Z40 Transcriptional regulator HFZ78_23225 ENOG4105BZU Histidine kinase HFZ78_23230 ENOG4105BZU Histidine kinase HFZ78_23240 ENOG4105C7K acetolactate synthase HFZ78_23245 ENOG4105DTQ mandelate racemase muconate lactonizing HFZ78_23260 ENOG4105E5Q amino acid AbC transporter HFZ78_23265 ENOG4105EAB amino acid AbC transporter HFZ78_23305 ENOG4105DRP amino acid AbC transporter HFZ78_23310 ENOG4105EAD ABC transporter HFZ78_23315 ENOG4105CT1 (ABC) transporter HFZ78_23320 ENOG4105CDA abc transporter atp-binding protein HFZ78_23325 ENOG4105C85 amino acid HFZ78_23330 ENOG4105F0V Cell wall hydrolase HFZ78_23335 ENOG4105CGZ zinc metallopeptidase HFZ78_23340 ENOG4105ETE Transcriptional regulator (LacI family HFZ78_23355 ENOG4107RJ5 oxidoreductase HFZ78_23360 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HFZ78_23385 ENOG4105KRI phosphocarrier protein (HPr HFZ78_23405 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HFZ78_23445 ENOG4107QW4 alcohol dehydrogenase HFZ78_23450 ENOG41088CC tellurite resistance protein tehB HFZ78_23470 ENOG4108X4Q Hydrolase HFZ78_23475 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HFZ78_23480 ENOG4105CPC Aldo Keto reductase HFZ78_23500 ENOG4108IPJ Membrane HFZ78_23505 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HFZ78_23525 ENOG4105D2N Aldolase HFZ78_23530 ENOG4105E70 isomerase HFZ78_23535 ENOG4108TVT permease HFZ78_23540 ENOG4105CJP fad dependent oxidoreductase HFZ78_23545 ENOG4107Y7Q pfkb domain protein HFZ78_23555 ENOG4105C01 Dihydroxy-acid dehydratase HFZ78_23565 ENOG4105CHR reductase HFZ78_23595 ENOG4105DRS transport system, permease HFZ78_23600 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HFZ78_23610 ENOG4105C5I Dehydrogenase HFZ78_23615 ENOG4107XWI flavin reductase domain protein, FMN-binding HFZ78_23620 ENOG4108I5G Major Facilitator superfamily HFZ78_23640 ENOG4108UHE carbonic anhydrase HFZ78_23660 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HFZ78_23665 ENOG4108KAM Transcriptional regulator HFZ78_23705 ENOG4107SET aldo keto reductase HFZ78_23720 ENOG4107U2T alpha beta HFZ78_23740 ENOG4105EMU Dehydrogenase HFZ78_23755 ENOG4105DQ6 Transposase HFZ78_23795 ENOG4105C6K Malic enzyme HFZ78_23805 ENOG4105E39 Enoyl-CoA hydratase HFZ78_23825 ENOG4105EW6 flavin reductase domain protein, FMN-binding HFZ78_23840 ENOG41080HJ 6-phospho 3-hexuloisomerase HFZ78_23845 ENOG4108VA3 3-hexulose-6-phosphate synthase HFZ78_23875 ENOG4105W5Q DNA repair protein (RadC HFZ78_24050 ENOG4105DND Transcriptional regulator HFZ78_24080 ENOG4107RSM transcriptional regulator HFZ78_24125 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HFZ78_24185 ENOG4105DXI Major Facilitator superfamily HFZ78_24190 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HFZ78_24200 ENOG4105DEN Luciferase family HFZ78_24235 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HFZ78_24240 ENOG4105D3R alkyl hydroperoxide reductase HFZ78_24255 ENOG4105CEY Amp-dependent synthetase and ligase HFZ78_24270 ENOG410667J hydrolase HFZ78_24280 ENOG4105VEQ Cold shock protein HFZ78_24345 ENOG4105D9P serine threonine protein kinase HFZ78_24360 ENOG4105CPK Glycosyl transferase (Group 1 HFZ78_24365 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HFZ78_24390 ENOG4107ZXU DSBA oxidoreductase HFZ78_24400 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HFZ78_24420 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HFZ78_24430 ENOG4107S1Q Phosphatase HFZ78_24450 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HFZ78_24455 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HFZ78_24530 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HFZ78_24535 ENOG4105CGK Exodeoxyribonuclease III HFZ78_24540 ENOG4105PXI polysaccharide deacetylase HFZ78_24545 ENOG4107ZE5 PPIases accelerate the folding of proteins HFZ78_24560 ENOG4105EWU Squalene--hopene cyclase HFZ78_24565 ENOG4108VCA G U mismatch-specific DNA glycosylase HFZ78_24570 ENOG4107AYK membrAne HFZ78_24575 ENOG4105DFD Na H antiporter HFZ78_24585 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HFZ78_24590 ENOG4105C0H protease HFZ78_24595 ENOG4105BZU Histidine kinase HFZ78_24600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HFZ78_24605 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HFZ78_24610 ENOG4105E39 Enoyl-CoA hydratase HFZ78_24625 ENOG4108IG5 Transcriptional regulator HFZ78_24630 ENOG4105CEY Amp-dependent synthetase and ligase HFZ78_24635 ENOG4105CHR reductase HFZ78_24640 ENOG4105C1G acyl-Coa dehydrogenase HFZ78_24650 ENOG41073R8 VanW family HFZ78_24665 ENOG4106DDH Sporulation-specific SASP protein HFZ78_24670 ENOG4108JYZ YitT family HFZ78_24690 ENOG4108QY0 Membrane HFZ78_24700 ENOG4108QCI YvbH-like oligomerisation region HFZ78_24705 ENOG4108TVJ Nitroreductase HFZ78_24710 ENOG4105KVH Transcriptional regulator HFZ78_24715 ENOG4107AYK membrAne HFZ78_24720 ENOG4108IQI permease HFZ78_24735 ENOG4105C5S asparaginyl-tRNA synthetase HFZ78_24760 ENOG4105EEM helicase HFZ78_24775 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HFZ78_24800 ENOG4108X4Q Hydrolase HFZ78_24820 ENOG4108TGC Acyltransferase HFZ78_24835 ENOG4108TKH Nitroreductase HFZ78_24845 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HFZ78_24850 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HFZ78_24855 ENOG4105BZU Histidine kinase HFZ78_24890 ENOG4105CFH Aspartokinase HFZ78_24910 ENOG4105ERH Fumarylacetoacetate hydrolase HFZ78_24915 ENOG4107XWI flavin reductase domain protein, FMN-binding HFZ78_24920 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HFZ78_24925 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HFZ78_24930 ENOG4105C7J ABC transporter, permease HFZ78_24940 ENOG4107RWR Sodium hydrogen exchanger HFZ78_24960 ENOG4107Y9E nuclease HFZ78_24975 ENOG4106GRI small acid-soluble spore protein H HFZ78_24985 ENOG4105FDT acyl-CoA dehydrogenase HFZ78_24995 ENOG4105CZN Potassium uptake protein HFZ78_25005 ENOG4105DQQ Major facilitator superfamily MFS_1 HFZ78_25010 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HFZ78_25015 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HFZ78_25020 ENOG4105BZU Histidine kinase HFZ78_25050 ENOG41067MG lrgb family HFZ78_25055 ENOG4105VAW lrga family HFZ78_25060 ENOG4108ZX6 Electron transport protein SCO1 SenC HFZ78_25065 ENOG4105C5H ABC transporter HFZ78_25075 ENOG4106AUC UPF0180 protein HFZ78_25080 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HFZ78_25085 ENOG4105E0C molybdate abc transporter HFZ78_25090 ENOG4105DZ1 carboxypeptidase HFZ78_25110 ENOG4105F1A Pyruvate formate-lyase HFZ78_25130 ENOG4105WMR Protein CrcB homolog HFZ78_25155 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HFZ78_25185 ENOG4105DDQ anthranilate synthase HFZ78_25190 ENOG4105CRQ synthase (Component I) HFZ78_25200 ENOG4105DM4 PTS System HFZ78_25205 ENOG4105DE4 1-phosphofructokinase HFZ78_25210 ENOG4105E98 transcriptional regulator DeoR family HFZ78_25235 ENOG4105VEQ Cold shock protein HFZ78_25245 ENOG4105FDF Could be involved in DNA repair (By similarity) HFZ78_25250 ENOG4105DQE DNA ligase HFZ78_25255 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HFZ78_25315 ENOG4105CKI cobalamin synthesis protein HFZ78_25330 ENOG4105C59 p-type ATPase HFZ78_25340 ENOG4106Z5R HFZ78_25345 ENOG4108N23 SpoOM-related protein HFZ78_25350 ENOG4105G0J serine threonine protein kinase HFZ78_25370 ENOG4105VSD UPF0346 protein HFZ78_25380 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HFZ78_25385 ENOG4108JUB Transcriptional regulator HFZ78_25390 ENOG4108TSC N-acetyltransferase HFZ78_25395 ENOG4107S4Y M20 DapE family protein YgeY HFZ78_25410 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HFZ78_25420 ENOG4105DZ0 fad dependent oxidoreductase HFZ78_25435 ENOG4105E0X reductase HFZ78_25440 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HFZ78_25460 ENOG41090WU lipolytic protein G-D-S-L family HFZ78_25465 ENOG4108KF3 Electron transport protein SCO1 SenC HFZ78_25485 ENOG4108RCR degv family HFZ78_25495 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HFZ78_25500 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HFZ78_25510 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HFZ78_25515 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HFZ78_25525 ENOG4106FN3 tellurium resistance protein HFZ78_25530 ENOG4108N0M stress protein HFZ78_25540 ENOG4108TTB tellurium resistance protein HFZ78_25570 ENOG4107TS3 membrane protein, TerC HFZ78_25575 ENOG4106FN3 tellurium resistance protein HFZ78_25585 ENOG4108Y6J UPF0403 protein HFZ78_25595 ENOG4105C5H ABC transporter HFZ78_25605 ENOG4108RCR degv family HFZ78_25620 ENOG4105CVG Homoserine O-transsuccinylase HFZ78_25630 ENOG4105KST dependent repressor HFZ78_25635 ENOG4105C9U ATP-dependent DNA helicase RecQ HFZ78_25660 ENOG41081VK Ribonuclease HFZ78_25700 ENOG4107SBE Glycosyl transferase (Group 1 HFZ78_25725 ENOG4105KHC sulfurtransferase HFZ78_25730 ENOG410890F Dynamin family HFZ78_25740 ENOG41065KQ synthase HFZ78_25750 ENOG4105NAA Cytochrome C oxidase, subunit II HFZ78_25755 ENOG4107RQ2 Cytochrome c oxidase, subunit I HFZ78_25760 ENOG4105CTD carboxy-peptidase HFZ78_25770 ENOG4105DSQ Nitric oxide reductase HFZ78_25795 ENOG4105VG1 fes assembly suf system protein HFZ78_25800 ENOG4105DVT helicase HFZ78_25805 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HFZ78_25815 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) HFZ78_25820 ENOG4106F55 Protein of unknown function (DUF1273) HFZ78_25830 ENOG4107X2U Inherit from COG: Exonuclease-like protein HFZ78_25835 ENOG4108I5C dEAD DEAH box helicase HFZ78_25840 ENOG4105IJJ transcriptional regulator, crp fnr family HFZ78_25845 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HFZ78_25850 ENOG4105MYT Heat shock protein HFZ78_25880 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HFZ78_25885 ENOG4105BZ4 penicillin-binding protein HFZ78_25895 ENOG4105CSM endonuclease III HFZ78_25915 ENOG4105YAC HFZ78_25925 ENOG4105DVT helicase HFZ78_25930 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HFZ78_25935 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HFZ78_25950 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HFZ78_25955 ENOG4105CPK Glycosyl transferase (Group 1 HFZ78_25960 ENOG4105FJR Lmbe family HFZ78_25965 ENOG4108Z5K methylglyoxal synthase HFZ78_25970 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HFZ78_25975 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HFZ78_25980 ENOG4108JYZ YitT family HFZ78_25995 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit HFZ78_26000 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HFZ78_26005 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HFZ78_26020 ENOG41068YB TPR repeat-containing protein HFZ78_26040 ENOG4105CIH Imidazole acetol-phosphate transaminase HFZ78_26045 ENOG4105KHN chorismate mutase HFZ78_26050 ENOG4105D49 3-dehydroquinate synthase HFZ78_26060 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HFZ78_26065 ENOG4105EAH synthase HFZ78_26070 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HFZ78_26080 ENOG4105WP2 Tryptophan RNA-binding attenuator protein HFZ78_26085 ENOG4105EUJ GTP cyclohydrolase i HFZ78_26090 ENOG4105K70 DNA-binding protein HFZ78_26095 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HFZ78_26110 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HFZ78_26115 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HFZ78_26130 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HFZ78_26135 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HFZ78_26145 ENOG4105CAT Cytidine monophosphate kinase HFZ78_26155 ENOG4105MSI germination protein ypeb HFZ78_26160 ENOG4105F0V Cell wall hydrolase HFZ78_26170 ENOG4105HDK L-asparaginase HFZ78_26175 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HFZ78_26190 ENOG4107RGJ metallophosphoesterase HFZ78_26210 ENOG4105WEF catalase HFZ78_26220 ENOG4105FEA Spore maturation protein HFZ78_26225 ENOG4105I7S Abortive infection protein HFZ78_26230 ENOG4105C9U ATP-dependent DNA helicase RecQ HFZ78_26245 ENOG4108SAX Membrane HFZ78_26270 ENOG4105BZU Histidine kinase HFZ78_26275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HFZ78_26280 ENOG4105CRE cytochrome C HFZ78_26285 ENOG4107TWT Cytochrome c biogenesis protein HFZ78_26290 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HFZ78_26295 ENOG4105FE9 pseudouridine synthase HFZ78_26305 ENOG4108JIC nucleoside recognition domain protein HFZ78_26310 ENOG4105DZ1 carboxypeptidase HFZ78_26315 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HFZ78_26330 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HFZ78_26335 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HFZ78_26355 ENOG4105PTM secreted protein HFZ78_26370 ENOG4105G6R Stage v sporulation protein ae HFZ78_26385 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HFZ78_26390 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HFZ78_26395 ENOG41082AN stage II sporulation protein HFZ78_26400 ENOG4105DZ1 carboxypeptidase HFZ78_26420 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HFZ78_26430 ENOG4105I3K Ferric uptake regulator, Fur family HFZ78_26435 ENOG4105MZ9 stage II sporulation protein m HFZ78_26455 ENOG4105CPC Aldo Keto reductase HFZ78_26465 ENOG4108IIH CoA-transferase subunit B HFZ78_26470 ENOG4105D6N CoA-transferase, subunit a HFZ78_26485 ENOG4106HZJ HFZ78_26495 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HFZ78_26505 ENOG4105BZU Histidine kinase HFZ78_26510 ENOG4108IXY short-chain dehydrogenase reductase HFZ78_26515 ENOG41069FQ Metallo-beta-lactamase superfamily HFZ78_26520 ENOG4105II7 pyrroline-5-carboxylate reductase HFZ78_26525 ENOG4107S6X Glycosyl transferase, family 2 HFZ78_26530 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HFZ78_26535 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HFZ78_26540 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HFZ78_26545 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HFZ78_26550 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HFZ78_26555 ENOG4108HNZ carboxyl transferase HFZ78_26560 ENOG4108ZVT methylmalonyl-coA epimerase HFZ78_26570 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HFZ78_26580 ENOG4105CDA abc transporter atp-binding protein HFZ78_26585 ENOG4105E5Q amino acid AbC transporter HFZ78_26590 ENOG4108HW3 (ABC) transporter HFZ78_26600 ENOG4108Y6J UPF0403 protein HFZ78_26605 ENOG4105DJT lAO AO transport system ATPase HFZ78_26610 ENOG4105D5P Methylmalonyl-coA mutase HFZ78_26615 ENOG4105CMN Methylmalonyl-coA mutase HFZ78_26620 ENOG4105C7S Dehydrogenase HFZ78_26625 ENOG4105CPP Dehydrogenase, E1 component HFZ78_26645 ENOG4107RDP Dehydrogenase HFZ78_26655 ENOG4108JUB Transcriptional regulator HFZ78_26660 ENOG4106CCJ Protein of unknown function (DUF2627) HFZ78_26665 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HFZ78_26675 ENOG4107QQR Sporulation HFZ78_26680 ENOG4105S1Z Stage IV sporulation protein B HFZ78_26685 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HFZ78_26695 ENOG4105DX0 Hemolysin A HFZ78_26700 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HFZ78_26720 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HFZ78_26725 ENOG4105M7K Involved in the transcription termination process (By similarity) HFZ78_26730 ENOG4108ZSR alkaline shock protein HFZ78_26735 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HFZ78_26755 ENOG410644B Stage III sporulation protein af HFZ78_26765 ENOG4105KQ4 Stage iii sporulation protein ad HFZ78_26770 ENOG4108CQH stage III sporulation protein AC HFZ78_26775 ENOG4105KR5 Stage iii sporulation protein HFZ78_26780 ENOG4105CD2 stage iii sporulation protein aa HFZ78_26790 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HFZ78_26800 ENOG41060IM Heme exporter protein HFZ78_26810 ENOG4108IUW ABC transporter HFZ78_26830 ENOG4105DA4 cytochrome c-type biogenesis protein HFZ78_26835 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HFZ78_26860 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HFZ78_26865 ENOG4105DC7 peptidase M24 HFZ78_26875 ENOG4105CBJ Metal-dependent enzyme HFZ78_26895 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HFZ78_26900 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HFZ78_26905 ENOG4105WZW rhodanese family HFZ78_26915 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HFZ78_26920 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HFZ78_26925 ENOG4105C0D helicase HFZ78_26945 ENOG4106855 Competence protein HFZ78_26990 ENOG4105C5X domain protein HFZ78_27010 ENOG4105DKQ ROK family HFZ78_27020 ENOG4107ZXI Rhomboid family HFZ78_27040 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HFZ78_27045 ENOG4105WDJ 50S ribosomal protein L33 HFZ78_27065 ENOG4108UTW Plays a role in the regulation of phosphate uptake HFZ78_27070 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HFZ78_27075 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HFZ78_27080 ENOG4105E2Z phosphate ABC transporter (Permease HFZ78_27085 ENOG4105C8U phosphate abc transporter HFZ78_27090 ENOG4105CVA phosphate HFZ78_27095 ENOG4107RF6 penicillin-binding protein HFZ78_27110 ENOG4107V6Q Cyclic nucleotide-binding domain HFZ78_27120 ENOG4105SXS Protein of unknown function (DUF456) HFZ78_27135 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HFZ78_27140 ENOG41063Y9 HFZ78_27145 ENOG4108U5J '-nucleotidase HFZ78_27155 ENOG4105N80 Ferric uptake regulator, Fur family HFZ78_27160 ENOG4105FAV ABC, transporter HFZ78_27165 ENOG4105FDK ABC transporter HFZ78_27170 ENOG41069ZM Protein of unknown function (DUF2624) HFZ78_27175 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HFZ78_27190 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HFZ78_27195 ENOG4105EGD dinuclear metal center protein, YbgI family HFZ78_27210 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HFZ78_27215 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HFZ78_27220 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HFZ78_27230 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HFZ78_27235 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HFZ78_27245 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HFZ78_27250 ENOG4107YR5 Diacylglycerol kinase HFZ78_27255 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HFZ78_27260 ENOG4105CTJ Metal Dependent Phosphohydrolase HFZ78_27265 ENOG4105C9A Phoh family HFZ78_27275 ENOG41068P3 sporulation protein YqfC HFZ78_27285 ENOG4105DI5 UPF0365 protein HFZ78_27290 ENOG4105F7J membrane-bound serine protease HFZ78_27295 ENOG4105KTH gatB Yqey HFZ78_27310 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HFZ78_27315 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HFZ78_27320 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HFZ78_27325 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HFZ78_27330 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HFZ78_27335 ENOG4105CFG Acts as a chaperone (By similarity) HFZ78_27340 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HFZ78_27350 ENOG4105CSA Coproporphyrinogen iii oxidase HFZ78_27355 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HFZ78_27365 ENOG4108ZRV stage ii sporulation protein p HFZ78_27375 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HFZ78_27380 ENOG4105TQK DNA polymerase iii, delta' subunit HFZ78_27390 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HFZ78_27395 ENOG4108UK2 deaminase HFZ78_27400 ENOG4105KQC Competence protein HFZ78_27410 ENOG4105DXX methyltransferase HFZ78_27420 ENOG4108WF2 Metal Dependent Phosphohydrolase HFZ78_27425 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HFZ78_27430 ENOG410812S Rna-binding protein HFZ78_27440 ENOG4105CQW ribosome biogenesis GTPase YqeH HFZ78_27445 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HFZ78_27455 ENOG4105DJ4 phosphatidylserine decarboxylase HFZ78_27460 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HFZ78_27465 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HFZ78_27475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HFZ78_27500 ENOG4105C28 cystathionine HFZ78_27520 ENOG4107XRG penicillin-binding protein HFZ78_27525 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HFZ78_27530 ENOG4105DBI uridine monophosphokinase HFZ78_27535 ENOG4105CFP Peptidase U32 HFZ78_27540 ENOG4105XYU peptidase (U32 family) HFZ78_27550 ENOG4105HHA aminodeoxychorismate lyase HFZ78_27555 ENOG4105VPH UPF0473 protein HFZ78_27560 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HFZ78_27565 ENOG4105VBH UPF0297 protein HFZ78_27570 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HFZ78_27575 ENOG4105C02 permease HFZ78_27585 ENOG41060CR HFZ78_27595 ENOG4105C7H Helicase, RecD TraA family HFZ78_27605 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HFZ78_27610 ENOG4105C3J Cysteine desulfurase HFZ78_27620 ENOG4105D1H recombination factor protein RarA HFZ78_27625 ENOG4108TU7 Inherit from COG: (ABC) transporter HFZ78_27630 ENOG4105CJ1 ABC, transporter HFZ78_27640 ENOG4105CUZ uba thif-type nad fad binding protein HFZ78_27650 ENOG4105C9M aspartyl-trna synthetase HFZ78_27655 ENOG4105CUT histidyl-tRNA synthetase HFZ78_27665 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HFZ78_27670 ENOG4105EA8 2-Nitropropane dioxygenase HFZ78_27685 ENOG4105E39 Enoyl-CoA hydratase HFZ78_27690 ENOG4105CHU acetyl-coa acetyltransferase HFZ78_27695 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HFZ78_27700 ENOG4105C26 Dehydrogenase HFZ78_27705 ENOG4108UKI Enoyl-CoA hydratase HFZ78_27735 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HFZ78_27740 ENOG4105DZS Phenylacetate-CoA ligase HFZ78_27760 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HFZ78_27765 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HFZ78_27770 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HFZ78_27775 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HFZ78_27780 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HFZ78_27790 ENOG4105CKP Polysaccharide Biosynthesis Protein HFZ78_27795 ENOG4108QG2 Membrane HFZ78_27800 ENOG4105NAP HFZ78_27805 ENOG4105VIE preprotein translocase, subunit YajC HFZ78_27815 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HFZ78_27825 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HFZ78_27850 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HFZ78_27855 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HFZ78_27860 ENOG4108IYU L-aspartate oxidase HFZ78_27875 ENOG4105CQC Prephenate dehydratase HFZ78_27880 ENOG41090I5 UPF0735 ACT domain-containing protein HFZ78_27885 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HFZ78_27895 ENOG4105K46 50S ribosomal protein l27 HFZ78_27900 ENOG4105X36 (ribosomal) protein HFZ78_27905 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HFZ78_27910 ENOG4105C03 ribonuclease HFZ78_27925 ENOG4107QMS site-determining protein HFZ78_27930 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HFZ78_27940 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HFZ78_27945 ENOG4105DFF Rod shape-determining protein mreb HFZ78_27950 ENOG4105W5Q DNA repair protein (RadC HFZ78_27985 ENOG4106A3R peptidase HFZ78_27990 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HFZ78_27995 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HFZ78_28010 ENOG41068KH stage VI sporulation protein D HFZ78_28010 ENOG41068KH stage VI sporulation protein D HFZ78_28020 ENOG4105D52 delta-aminolevulinic acid dehydratase HFZ78_28030 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HFZ78_28040 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HFZ78_28055 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HFZ78_28060 ENOG4108IUQ atp-dependent protease HFZ78_28065 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HFZ78_28070 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HFZ78_28085 ENOG4105M59 Phosphodiesterase, mj0936 family HFZ78_28090 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HFZ78_28095 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HFZ78_28100 ENOG4108XJQ germination protein HFZ78_28110 ENOG41067TZ transcriptional regulator, MarR family HFZ78_28115 ENOG4105W8X HesB YadR YfhF-family protein HFZ78_28120 ENOG4105BZU Histidine kinase HFZ78_28125 ENOG4105BZU Histidine kinase HFZ78_28135 ENOG4105PFC Transcriptional regulator HFZ78_28145 ENOG4105E33 succinate dehydrogenase HFZ78_28155 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HFZ78_28170 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HFZ78_28175 ENOG4105K63 Thioredoxin HFZ78_28180 ENOG4105C10 Electron transfer flavoprotein HFZ78_28185 ENOG4105BZJ Electron transfer flavoprotein HFZ78_28190 ENOG41060WC Enoyl-CoA hydratase HFZ78_28195 ENOG4107Z3H Transcriptional regulator, TetR family HFZ78_28200 ENOG4105CEY Amp-dependent synthetase and ligase HFZ78_28215 ENOG4105DCG PHP domain protein HFZ78_28225 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HFZ78_28235 ENOG4105KZX Pterin carbinolamine dehydratase HFZ78_28240 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HFZ78_28245 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HFZ78_28250 ENOG4108RWN rrna methyltransferase HFZ78_28260 ENOG4105CN9 Peptidase m42 family protein HFZ78_28270 ENOG4105E1K spore germination protein HFZ78_28280 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HFZ78_28290 ENOG410696E Membrane HFZ78_28295 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HFZ78_28300 ENOG4105VJV 50s ribosomal protein L35 HFZ78_28305 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HFZ78_28310 ENOG4105C22 threonyL-tRNA synthetase HFZ78_28315 ENOG4108TDW sporulation protein YtxC HFZ78_28330 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HFZ78_28340 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HFZ78_28345 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HFZ78_28350 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HFZ78_28360 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HFZ78_28365 ENOG4105C2M dna polymerase I HFZ78_28370 ENOG4105BZU Histidine kinase HFZ78_28375 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HFZ78_28390 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HFZ78_28395 ENOG4108HMX isocitrate dehydrogenase (NADP) HFZ78_28400 ENOG4105BZN citrate synthase HFZ78_28405 ENOG4107CWS Protein of unknown function (DUF441) HFZ78_28410 ENOG4108REF Sporulation integral membrane protein ytvi HFZ78_28415 ENOG4105FS0 cytoplasmic membrane protein HFZ78_28420 ENOG4105CA9 Pyruvate kinase HFZ78_28430 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HFZ78_28435 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HFZ78_28440 ENOG4107YCY Transcriptional regulator HFZ78_28445 ENOG4105C6K Malic enzyme HFZ78_28450 ENOG4105C0B DNA polymerase III (alpha subunit) HFZ78_28455 ENOG4105VV2 HFZ78_28465 ENOG4105SFS phosphoesterase RecJ domain protein HFZ78_28485 ENOG4105E8R UPF0173 metal-dependent hydrolase HFZ78_28490 ENOG4105DC7 peptidase M24 HFZ78_28515 ENOG4107YZX Universal stress protein HFZ78_28525 ENOG4105EPU Molybdenum cofactor synthesis domain protein HFZ78_28535 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HFZ78_28545 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HFZ78_28550 ENOG4105KBJ sporulation protein ytfj HFZ78_28560 ENOG4105VK3 rdd domain containing protein HFZ78_28565 ENOG4105D07 Signal peptide peptidase, SppA HFZ78_28570 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HFZ78_28575 ENOG4105FR1 rard protein HFZ78_28580 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HFZ78_28590 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HFZ78_28600 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) HFZ78_28605 ENOG4105U5Y Transcriptional regulator HFZ78_28615 ENOG4105C28 cystathionine HFZ78_28620 ENOG4105BZU Histidine kinase HFZ78_28625 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HFZ78_28630 ENOG4106UIA HFZ78_28635 ENOG4106UIA HFZ78_28660 ENOG4105F1V Acetoin utilization protein HFZ78_28665 ENOG4105W87 Cbs domain HFZ78_28670 ENOG4105DGU Histone deacetylase HFZ78_28675 ENOG4105ETE Transcriptional regulator (LacI family HFZ78_28680 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HFZ78_28700 ENOG4105C88 aminopeptidase HFZ78_28705 ENOG4105DFU Cell wall formation (By similarity) HFZ78_28715 ENOG4108NKM UPF0354 protein HFZ78_28740 ENOG4105C8F Beta-lactamase domain protein HFZ78_28745 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HFZ78_28755 ENOG4108V15 phosphotransferase enzyme family HFZ78_28760 ENOG4108IUM Glycogen debranching enzyme HFZ78_28775 ENOG4105C6T cysteine synthase HFZ78_28785 ENOG4105YW5 deoR family transcriptional regulator HFZ78_28795 ENOG4107RSM transcriptional regulator HFZ78_28805 ENOG41082BM Transcriptional regulator, arsr family HFZ78_28815 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HFZ78_28820 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HFZ78_28825 ENOG4108RMU ferritin dps family protein HFZ78_28845 ENOG4105CBX hi0933 family HFZ78_28870 ENOG41085GJ domain protein HFZ78_28875 ENOG4105C8T Leucyl-tRNA synthetase HFZ78_28880 ENOG410605W Major Facilitator HFZ78_28885 ENOG4105EAU Plays a role in nitrite reduction (By similarity) HFZ78_28905 ENOG4105N5T Radical SAM Protein HFZ78_28920 ENOG4105E8V Alpha Beta Hydrolase Fold protein HFZ78_28925 ENOG4108Z0R Transferase HFZ78_28930 ENOG4105CAQ asparagine synthetase HFZ78_28935 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HFZ78_28955 ENOG4105D2X ABC transporter substrate-binding protein HFZ78_28965 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HFZ78_28970 ENOG4105M6F mutator MutT protein HFZ78_28990 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HFZ78_28995 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HFZ78_29000 ENOG4108V2W Carbonate dehydratase HFZ78_29010 ENOG4105DTQ mandelate racemase muconate lactonizing HFZ78_29015 ENOG4105CEY Amp-dependent synthetase and ligase HFZ78_29020 ENOG4108IPT Naphthoate synthase HFZ78_29025 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HFZ78_29030 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HFZ78_29035 ENOG4105E4F Isochorismate synthase HFZ78_29040 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HFZ78_29050 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HFZ78_29190 ENOG4105KT7 mgtC SapB transporter HFZ78_29210 ENOG4105C1J atp-dependent rna helicase HFZ78_29225 ENOG4105E2A Dehydrogenase HFZ78_29230 ENOG4105PGS Spore coat protein HFZ78_29250 ENOG4105CEY Amp-dependent synthetase and ligase HFZ78_29270 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HFZ78_29275 ENOG4105C32 Amino acid ABC transporter (Permease) HFZ78_29280 ENOG4108IV0 ABC, transporter HFZ78_29285 ENOG4105C0Z ABC transporter HFZ78_29300 ENOG4105BZU Histidine kinase HFZ78_29305 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HFZ78_29310 ENOG4105D6E homoserine dehydrogenase HFZ78_29315 ENOG4108JQ1 Dehydrogenase HFZ78_29325 ENOG4105C26 Dehydrogenase HFZ78_29330 ENOG4108JPW Aminotransferase HFZ78_29335 ENOG4105C8Y Acetylornithine aminotransferase HFZ78_29345 ENOG4108JUB Transcriptional regulator HFZ78_29360 ENOG4105CUB amino acid HFZ78_29370 ENOG4108RMU ferritin dps family protein HFZ78_29395 ENOG4107ZQN disulfide bond HFZ78_29410 ENOG4105DRS transport system, permease HFZ78_29435 ENOG4105BZ1 (ABC) transporter HFZ78_29440 ENOG4105BZ1 (ABC) transporter HFZ78_29460 ENOG4105CE4 GlcNAc 6-P deacetylase HFZ78_29475 ENOG4105CNT hydrolase family 2 HFZ78_29480 ENOG4105CNT hydrolase family 2 HFZ78_29485 ENOG4105CK5 oxidoreductase HFZ78_29490 ENOG4107RJ5 oxidoreductase HFZ78_29495 ENOG4105E98 transcriptional regulator DeoR family HFZ78_29520 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HFZ78_29525 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HFZ78_29530 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HFZ78_29535 ENOG4105BZ7 extracellular solute-binding protein family 1 HFZ78_29570 ENOG4105DKQ ROK family HFZ78_29575 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HFZ78_29580 ENOG4105G63 Type III effector Hrp-dependent HFZ78_29585 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HFZ78_29590 ENOG4105C8I hydrolase, family 38 HFZ78_29620 ENOG4105DRS transport system, permease HFZ78_29630 ENOG4105ETE Transcriptional regulator (LacI family HFZ78_29635 ENOG4105MU9 integral membrane protein HFZ78_29645 ENOG4105C8I hydrolase, family 38 HFZ78_29660 ENOG4105EF1 ribulokinase HFZ78_29685 ENOG4107YY3 extracellular solute-binding protein family 1 HFZ78_29690 ENOG4105EQD regulatoR HFZ78_29695 ENOG4105C2F Histidine kinase HFZ78_29700 ENOG4105CJQ hydrolase, family 31 HFZ78_29715 ENOG4107FKK extracellular solute-binding protein family 1 HFZ78_29720 ENOG4108HRK Histidine kinase HFZ78_29725 ENOG4105EQD regulatoR HFZ78_29730 ENOG4105DG6 mannose-6-phosphate isomerase HFZ78_29735 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HFZ78_29755 ENOG4105H93 Acyltransferase family HFZ78_29775 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HFZ78_29790 ENOG4105D3Q Sugar transferase HFZ78_29810 ENOG4107T8Q Glycosyl transferase (Group 1 HFZ78_29825 ENOG4108QV3 biosynthesis protein HFZ78_29830 ENOG4105HTX biosynthesis protein HFZ78_29840 ENOG4105C1B dTDP-glucose 4-6-dehydratase HFZ78_29850 ENOG4105C28 cystathionine HFZ78_29855 ENOG4105C28 cystathionine HFZ78_29870 ENOG4107MII Sugar-specific transcriptional regulator TrmB HFZ78_29875 ENOG4105CZM Major Facilitator HFZ78_29880 ENOG4105C3M thioredoxin reductase HFZ78_29895 ENOG4105EUB pirin domain protein HFZ78_29925 ENOG4105D7N magnesium and cobalt transport protein CorA HFZ78_29930 ENOG41076HS cation diffusion facilitator family transporter HFZ78_29985 ENOG4107PBV potassium channel HFZ78_30000 ENOG4107QW4 alcohol dehydrogenase HFZ78_30010 ENOG4105C8Y Acetylornithine aminotransferase HFZ78_30030 ENOG4105KWG Pfam:DUF1696 HFZ78_30045 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HFZ78_30055 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HFZ78_30060 ENOG4105Y38 Kinase-associated protein B HFZ78_30070 ENOG4105KA0 thioesterase Superfamily protein HFZ78_30080 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HFZ78_30085 ENOG41069ER domain protein HFZ78_30105 ENOG4105CEP NADH dehydrogenase HFZ78_30120 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HFZ78_30145 ENOG41083MR nifu domain-containing protein HFZ78_30155 ENOG4108W5N phosphatidylglycerophosphatase a HFZ78_30160 ENOG4105D4U had-superfamily hydrolase, subfamily iia HFZ78_30180 ENOG4105MMD transcriptional regulator HFZ78_30185 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HFZ78_30190 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HFZ78_30195 ENOG4105FAA peptidase M23 HFZ78_30200 ENOG4108YTE sporulation protein YunB HFZ78_30205 ENOG4105KZD Domain of unknown function (DUF1805) HFZ78_30210 ENOG4107R8B 5'-nucleotidase HFZ78_30220 ENOG4105I3N Conserved Protein HFZ78_30225 ENOG4105DIW FeS assembly protein SUFB HFZ78_30230 ENOG4108UNV SUF system FeS assembly protein, NifU family HFZ78_30235 ENOG4105C9B Cysteine desulfurase HFZ78_30240 ENOG4105JRK feS assembly protein SufD HFZ78_30245 ENOG4105C3K feS assembly ATPase SufC HFZ78_30250 ENOG4105D01 (LipO)protein HFZ78_30255 ENOG4108UMI ABC transporter, permease HFZ78_30260 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HFZ78_30295 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HFZ78_30300 ENOG41080E8 Transcriptional regulator, Spx MgsR family HFZ78_30305 ENOG4105C1G acyl-Coa dehydrogenase HFZ78_30310 ENOG4105CHU acetyl-coa acetyltransferase HFZ78_30345 ENOG4105E0A ABC, transporter HFZ78_30350 ENOG4108IHU transport system permease protein HFZ78_30355 ENOG4105DQ5 transport system permease protein HFZ78_30360 ENOG4108MES Periplasmic binding protein HFZ78_30375 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HFZ78_30380 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HFZ78_30385 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HFZ78_30400 ENOG4108IJ6 ABC transporter HFZ78_30410 ENOG4105EB3 Histidine kinase HFZ78_30415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HFZ78_30420 ENOG4105BZU Histidine kinase HFZ78_30425 ENOG4105DZ6 Band 7 protein HFZ78_30435 ENOG4105CDA abc transporter atp-binding protein HFZ78_30440 ENOG4105DRP amino acid AbC transporter HFZ78_30455 ENOG4108S4H thioesterase Superfamily protein HFZ78_30475 ENOG4106F5Q Membrane HFZ78_30480 ENOG4107VMI polysaccharide deacetylase HFZ78_30520 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HFZ78_30525 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HFZ78_30535 ENOG4105XZU Preprotein translocase, subunit SecG HFZ78_30540 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HFZ78_30545 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HFZ78_30555 ENOG4105BZA Phosphoglycerate kinase HFZ78_30575 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HFZ78_30585 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HFZ78_30590 ENOG4105KRI phosphocarrier protein (HPr HFZ78_30595 ENOG4105CIE May be required for sporulation (By similarity) HFZ78_30600 ENOG4105CHW UPF0052 protein HFZ78_30605 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HFZ78_30610 ENOG4108Z4K mutator MutT protein HFZ78_30615 ENOG4105C3M thioredoxin reductase HFZ78_30625 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HFZ78_30630 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HFZ78_30635 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HFZ78_30640 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HFZ78_30645 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HFZ78_30650 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HFZ78_30655 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HFZ78_30660 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HFZ78_30665 ENOG4105CGH 5'-nucleotidase HFZ78_30670 ENOG4108S4C acetyltransferase HFZ78_30675 ENOG4107XGZ Hydrolase HFZ78_30680 ENOG4105HKU nucleoside recognition domain-containing protein HFZ78_30685 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HFZ78_30690 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HFZ78_30695 ENOG41086DT Membrane protein of unknown function HFZ78_30700 ENOG4108PY7 HFZ78_30710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HFZ78_30715 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HFZ78_30725 ENOG4108IA2 Sodium pantothenate symporter HFZ78_30740 ENOG41090UD (LipO)protein HFZ78_30760 ENOG410681U heavy metal transport detoxification protein HFZ78_30775 ENOG4105PGM cation diffusion facilitator family transporter HFZ78_30800 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HFZ78_30810 ENOG4105E5Q amino acid AbC transporter HFZ78_30815 ENOG4105CDA abc transporter atp-binding protein HFZ78_30860 ENOG4107ZTW SNARE associated Golgi HFZ78_30870 ENOG41062D9 Histidine kinase HFZ78_30875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HFZ78_30890 ENOG4105CJ1 ABC, transporter HFZ78_30920 ENOG4105CN1 protease HFZ78_30930 ENOG4105CRP Part of the ABC transporter FtsEX involved in HFZ78_30935 ENOG4105CAK Cell division ATP-binding protein ftsE HFZ78_30960 ENOG41060AI SEC-C motif HFZ78_30985 ENOG4105CUW cytochrome C-TYPE protein HFZ78_30995 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HFZ78_31010 ENOG4105MJ2 Competence protein HFZ78_31040 ENOG4105WH1 Two component transcriptional regulator luxr family HFZ78_31045 ENOG4105BZU Histidine kinase HFZ78_31050 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HFZ78_31055 ENOG4108KGH TRANSCRIPTIONal HFZ78_31060 ENOG4105ESV Glycosyl transferase, family 4 HFZ78_31080 ENOG4107RZX Teichoic acid biosynthesis protein HFZ78_31085 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HFZ78_31150 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HFZ78_31170 ENOG41069ER domain protein HFZ78_31175 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HFZ78_31270 ENOG4107S6X Glycosyl transferase, family 2 HFZ78_31275 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HFZ78_31340 ENOG4105CMR udp-glucose 4-epimerase HFZ78_31345 ENOG4105C1B dTDP-glucose 4-6-dehydratase HFZ78_31350 ENOG4105K64 Glycosyl transferase, family 2 HFZ78_31370 ENOG4108VXD carboxy-peptidase HFZ78_31375 ENOG4105CDW Resistance protein HFZ78_31390 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HFZ78_31395 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HFZ78_31415 ENOG4105C0P Mg chelatase subunit ChlI HFZ78_31445 ENOG4108J2R molybdopterin oxidoreductase HFZ78_31450 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HFZ78_31455 ENOG4105CMR udp-glucose 4-epimerase HFZ78_31465 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HFZ78_31470 ENOG4105C19 ABC transporter HFZ78_31485 ENOG4105CVA phosphate HFZ78_31505 ENOG4108K8S endonuclease I HFZ78_31510 ENOG4105CGH 5'-nucleotidase HFZ78_31515 ENOG4108ZB6 transcriptional regulator AsnC family HFZ78_31520 ENOG4105CHM Aminotransferase HFZ78_31525 ENOG4105BZU Histidine kinase HFZ78_31530 ENOG4105C7N Xanthine uracil vitamin C permease HFZ78_31565 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HFZ78_31575 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HFZ78_31580 ENOG410605W Major Facilitator HFZ78_31585 ENOG4107TTA Xylose isomerase domain protein TIM barrel