locus-tag	class	description
HFZ78_00010	COG1175	transmembrane transport
HFZ78_00015	COG1653	transport
HFZ78_00020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_00025	COG2188	Transcriptional regulator
HFZ78_00040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HFZ78_00080	COG0842	Transport permease protein
HFZ78_00090	COG1131	(ABC) transporter
HFZ78_00165	COG1175	transmembrane transport
HFZ78_00180	COG5578	integral membrane protein
HFZ78_00210	COG4638	Rieske (2fe-2S)
HFZ78_00225	COG0028	Belongs to the TPP enzyme family
HFZ78_00230	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_00245	COG2223	nitrite transmembrane transporter activity
HFZ78_00250	COG1414	Transcriptional regulator
HFZ78_00265	COG2323	membrane
HFZ78_00295	COG2259	Doxx family
HFZ78_00310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HFZ78_00320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFZ78_00325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HFZ78_00330	COG0640	Transcriptional regulator
HFZ78_00345	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_00345	COG3347	Dehydrogenase
HFZ78_00350	COG0395	ABC-type sugar transport system, permease component
HFZ78_00360	COG1653	transport
HFZ78_00365	COG0626	cystathionine gamma-synthase activity
HFZ78_00380	COG3300	MHYT domain
HFZ78_00380	COG5001	Diguanylate cyclase
HFZ78_00390	COG1917	Cupin 2, conserved barrel domain protein
HFZ78_00390	COG4977	sequence-specific DNA binding
HFZ78_00395	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HFZ78_00400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HFZ78_00405	COG1984	allophanate hydrolase subunit 2
HFZ78_00415	COG1263	PTS System
HFZ78_00415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_00420	COG1737	Transcriptional regulator
HFZ78_00430	COG0561	phosphatase activity
HFZ78_00435	COG0277	FAD linked oxidase domain protein
HFZ78_00440	COG0247	lactate metabolic process
HFZ78_00445	COG4977	sequence-specific DNA binding
HFZ78_00450	COG2986	histidine ammonia-lyase
HFZ78_00455	COG0477	Major facilitator Superfamily
HFZ78_00460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_00470	COG0473	3-isopropylmalate dehydrogenase activity
HFZ78_00475	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_00480	COG4638	Rieske (2fe-2S)
HFZ78_00500	COG0598	Magnesium transport protein CorA
HFZ78_00525	COG5002	protein histidine kinase activity
HFZ78_00530	COG0745	RESPONSE REGULATOR receiver
HFZ78_00550	COG1183	phosphatidylcholine synthase activity
HFZ78_00555	COG2217	Heavy metal translocating P-type atpase
HFZ78_00570	COG1760	l-serine dehydratase
HFZ78_00575	COG1760	l-serine dehydratase
HFZ78_00580	COG1113	amino acid transport
HFZ78_00585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_00595	COG3858	chitin binding
HFZ78_00595	COG1388	LysM domain
HFZ78_00605	COG1940	carbohydrate kinase activity
HFZ78_00615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HFZ78_00615	COG2199	diguanylate cyclase activity
HFZ78_00645	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HFZ78_00650	COG4172	Belongs to the ABC transporter superfamily
HFZ78_00655	COG4721	ABC-type cobalt transport system, permease component
HFZ78_00660	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HFZ78_00665	COG3135	benzoate transporter
HFZ78_00670	COG1879	ABC-type sugar transport system periplasmic component
HFZ78_00675	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ78_00680	COG1129	ABC transporter
HFZ78_00685	COG1869	D-ribose catabolic process
HFZ78_00690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_00695	COG1609	Transcriptional regulator
HFZ78_00720	COG0584	glycerophosphoryl diester phosphodiesterase
HFZ78_00725	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HFZ78_00780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_00800	COG0659	secondary active sulfate transmembrane transporter activity
HFZ78_00805	COG0288	reversible hydration of carbon dioxide
HFZ78_00810	COG1846	Transcriptional regulator
HFZ78_00815	COG1764	response to oxidative stress
HFZ78_00820	COG4086	secreted protein
HFZ78_00830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFZ78_00835	COG0805	protein transport
HFZ78_00845	COG1414	Transcriptional regulator
HFZ78_00850	COG2814	Major facilitator Superfamily
HFZ78_00885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFZ78_00890	COG1525	nuclease
HFZ78_00890	COG4085	toxin activity
HFZ78_00890	COG0737	Belongs to the 5'-nucleotidase family
HFZ78_00925	COG0390	transport system, permease component
HFZ78_00930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HFZ78_00940	COG0385	Bile acid
HFZ78_01110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ78_01110	COG4499	WXG100 protein secretion system (Wss), protein YukC
HFZ78_01115	COG0383	alpha-mannosidase activity
HFZ78_01120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_01120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_01120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_01125	COG1737	Transcriptional regulator
HFZ78_01130	COG1929	Belongs to the glycerate kinase type-1 family
HFZ78_01135	COG1482	cell wall glycoprotein biosynthetic process
HFZ78_01140	COG1842	Phage shock protein A
HFZ78_01165	COG2084	Dehydrogenase
HFZ78_01175	COG2610	gluconate transmembrane transporter activity
HFZ78_01180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFZ78_01185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ78_01215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFZ78_01220	COG1486	melibiose metabolic process
HFZ78_01225	COG1447	Phosphotransferase system cellobiose-specific component IIA
HFZ78_01230	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFZ78_01240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFZ78_01255	COG4821	SIS domain
HFZ78_01260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HFZ78_01270	COG2971	BadF BadG BcrA BcrD
HFZ78_01345	COG4187	Peptidase family M20/M25/M40
HFZ78_01350	COG1802	Transcriptional regulator
HFZ78_01355	COG0436	Aminotransferase
HFZ78_01360	COG2271	Major facilitator Superfamily
HFZ78_01365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFZ78_01375	COG1834	amidinotransferase
HFZ78_01380	COG0697	spore germination
HFZ78_01385	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_01440	COG3584	3D domain protein
HFZ78_01440	COG1388	LysM domain
HFZ78_01445	COG1132	(ABC) transporter
HFZ78_01450	COG1132	(ABC) transporter
HFZ78_01455	COG1940	carbohydrate kinase activity
HFZ78_01460	COG1940	carbohydrate kinase activity
HFZ78_01465	COG2723	6-phospho-beta-galactosidase activity
HFZ78_01470	COG2207	Transcriptional regulator
HFZ78_01470	COG4753	response regulator
HFZ78_01475	COG2972	Histidine kinase
HFZ78_01485	COG0395	ABC-type sugar transport system, permease component
HFZ78_01490	COG4209	transmembrane transport
HFZ78_01515	COG0383	alpha-mannosidase activity
HFZ78_01535	COG2814	Major facilitator Superfamily
HFZ78_01545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HFZ78_01550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HFZ78_01570	COG0457	Tetratricopeptide repeat
HFZ78_01570	COG0463	Glycosyl transferase, family 2
HFZ78_01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_01600	COG1126	abc transporter atp-binding protein
HFZ78_01605	COG0833	amino acid
HFZ78_01610	COG2986	histidine ammonia-lyase
HFZ78_01620	COG0252	asparaginase activity
HFZ78_01630	COG3739	integral membrane protein
HFZ78_01640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HFZ78_01645	COG1131	(ABC) transporter
HFZ78_01650	COG3655	Transcriptional regulator
HFZ78_01665	COG2247	cell wall binding repeat
HFZ78_01665	COG2385	sporulation resulting in formation of a cellular spore
HFZ78_01690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HFZ78_01705	COG1134	teichoic acid transport
HFZ78_01710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HFZ78_01845	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HFZ78_01845	COG0662	Cupin 2, conserved barrel domain protein
HFZ78_01855	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HFZ78_01870	COG0110	maltose O-acetyltransferase activity
HFZ78_01890	COG0438	transferase activity, transferring glycosyl groups
HFZ78_01920	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HFZ78_01925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_01930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HFZ78_01935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFZ78_01940	COG4464	protein tyrosine phosphatase activity
HFZ78_01945	COG0489	protein tyrosine kinase activity
HFZ78_01950	COG3944	biosynthesis protein
HFZ78_01965	COG1388	LysM domain
HFZ78_01965	COG0791	NLP P60 protein
HFZ78_01970	COG3152	Membrane
HFZ78_01985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_01990	COG0791	NLP P60 protein
HFZ78_01990	COG1388	LysM domain
HFZ78_02015	COG2188	Transcriptional regulator
HFZ78_02020	COG2723	6-phospho-beta-galactosidase activity
HFZ78_02025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFZ78_02030	COG1609	Transcriptional regulator
HFZ78_02035	COG0477	Major facilitator Superfamily
HFZ78_02100	COG2076	Multidrug Resistance protein
HFZ78_02105	COG2076	Multidrug Resistance protein
HFZ78_02110	COG0561	phosphatase activity
HFZ78_02145	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HFZ78_02150	COG1131	(ABC) transporter
HFZ78_02180	COG1392	Phosphate transport regulator
HFZ78_02200	COG3540	Alkaline phosphatase
HFZ78_02230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HFZ78_02255	COG2226	methyltransferase
HFZ78_02260	COG0656	L-ascorbic acid biosynthetic process
HFZ78_02265	COG2814	Major facilitator Superfamily
HFZ78_02270	COG1733	regulation of RNA biosynthetic process
HFZ78_02280	COG3584	3D domain protein
HFZ78_02280	COG1388	LysM domain
HFZ78_02290	COG1396	sequence-specific DNA binding
HFZ78_02300	COG0629	single-stranded DNA binding
HFZ78_02325	COG1077	Cell shape determining protein MreB Mrl
HFZ78_02330	COG1609	Transcriptional regulator
HFZ78_02340	COG3695	enzyme binding
HFZ78_02355	COG0768	penicillin binding
HFZ78_02365	COG0739	heme binding
HFZ78_02385	COG2385	sporulation resulting in formation of a cellular spore
HFZ78_02400	COG4836	Membrane
HFZ78_02420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFZ78_02425	COG0783	Belongs to the Dps family
HFZ78_02430	COG2208	phosphoserine phosphatase activity
HFZ78_02435	COG1191	sigma factor activity
HFZ78_02440	COG2172	sigma factor antagonist activity
HFZ78_02445	COG1366	Belongs to the anti-sigma-factor antagonist family
HFZ78_02450	COG2208	phosphoserine phosphatase activity
HFZ78_02455	COG2172	sigma factor antagonist activity
HFZ78_02460	COG1366	Belongs to the anti-sigma-factor antagonist family
HFZ78_02465	COG1366	Belongs to the anti-sigma-factor antagonist family
HFZ78_02480	COG0598	Magnesium transport protein CorA
HFZ78_02495	COG1366	Belongs to the anti-sigma-factor antagonist family
HFZ78_02500	COG1253	flavin adenine dinucleotide binding
HFZ78_02505	COG0668	transmembrane transport
HFZ78_02520	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HFZ78_02525	COG1007	ATP synthesis coupled electron transport
HFZ78_02535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HFZ78_02540	COG0713	ATP synthesis coupled electron transport
HFZ78_02545	COG0839	Belongs to the complex I subunit 6 family
HFZ78_02555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HFZ78_02560	COG0649	NAD binding
HFZ78_02565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFZ78_02570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFZ78_02575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFZ78_02590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HFZ78_02595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HFZ78_02600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HFZ78_02605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HFZ78_02610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HFZ78_02615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HFZ78_02620	COG0356	it plays a direct role in the translocation of protons across the membrane
HFZ78_02635	COG1404	Belongs to the peptidase S8 family
HFZ78_02645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HFZ78_02660	COG0698	ribose 5-phosphate isomerase
HFZ78_02670	COG1971	Probably functions as a manganese efflux pump
HFZ78_02675	COG0009	L-threonylcarbamoyladenylate synthase
HFZ78_02695	COG2890	protein-(glutamine-N5) methyltransferase activity
HFZ78_02700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HFZ78_02710	COG1435	thymidine kinase activity
HFZ78_02720	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HFZ78_02725	COG1494	fructose-1,6-bisphosphatase
HFZ78_02740	COG0191	fructose-bisphosphate aldolase activity
HFZ78_02745	COG2204	response regulator
HFZ78_02750	COG4821	SIS domain
HFZ78_02755	COG0504	CTP synthase activity
HFZ78_02760	COG3343	RNA polymerase activity
HFZ78_02770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_02770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_02770	COG1703	isobutyryl-CoA mutase activity
HFZ78_02780	COG1960	acyl-CoA dehydrogenase activity
HFZ78_02785	COG1960	acyl-CoA dehydrogenase activity
HFZ78_02790	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ78_02795	COG0183	Belongs to the thiolase family
HFZ78_02800	COG0247	lactate metabolic process
HFZ78_02800	COG2181	nitrate reductase activity
HFZ78_02805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFZ78_02830	COG0010	Belongs to the arginase family
HFZ78_02835	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HFZ78_02840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ78_02850	COG1994	Peptidase M50
HFZ78_02860	COG3465	dGTPase activity
HFZ78_02865	COG1078	dGTPase activity
HFZ78_02870	COG4844	belongs to the
HFZ78_02885	COG0280	phosphate acetyltransferase
HFZ78_02900	COG2363	Small membrane protein
HFZ78_02910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HFZ78_02915	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HFZ78_02920	COG0314	molybdopterin synthase activity
HFZ78_02925	COG1910	domain protein
HFZ78_02930	COG0303	'Molybdopterin
HFZ78_02935	COG0746	molybdenum cofactor guanylyltransferase activity
HFZ78_02945	COG0351	phosphomethylpyrimidine kinase
HFZ78_02950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFZ78_02960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_02970	COG4263	nitrous-oxide reductase activity
HFZ78_02990	COG1131	(ABC) transporter
HFZ78_03000	COG2133	pyrroloquinoline quinone binding
HFZ78_03005	COG0561	phosphatase activity
HFZ78_03035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFZ78_03050	COG0411	ABC transporter
HFZ78_03070	COG0477	Major facilitator Superfamily
HFZ78_03075	COG1132	(ABC) transporter
HFZ78_03080	COG1132	(ABC) transporter
HFZ78_03115	COG1131	(ABC) transporter
HFZ78_03130	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFZ78_03165	COG1376	ErfK ybiS ycfS ynhG family protein
HFZ78_03170	COG1187	pseudouridine synthase activity
HFZ78_03185	COG4989	oxidoreductase activity
HFZ78_03190	COG3584	3D domain protein
HFZ78_03190	COG1388	LysM domain
HFZ78_03200	COG1473	amidohydrolase
HFZ78_03205	COG1263	PTS System
HFZ78_03205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_03205	COG2190	(PTS) system
HFZ78_03210	COG2222	sugar isomerase
HFZ78_03215	COG2188	Transcriptional regulator
HFZ78_03225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_03230	COG1126	abc transporter atp-binding protein
HFZ78_03235	COG0765	amino acid transport
HFZ78_03240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_03245	COG0246	Mannitol dehydrogenase
HFZ78_03255	COG2721	sulfolactate sulfo-lyase activity
HFZ78_03260	COG1063	alcohol dehydrogenase
HFZ78_03265	COG2271	Major facilitator Superfamily
HFZ78_03270	COG1802	Transcriptional regulator
HFZ78_03285	COG0246	Mannitol dehydrogenase
HFZ78_03290	COG1312	Catalyzes the dehydration of D-mannonate
HFZ78_03295	COG1063	alcohol dehydrogenase
HFZ78_03300	COG2271	Major facilitator Superfamily
HFZ78_03305	COG2040	homocysteine
HFZ78_03310	COG0833	amino acid
HFZ78_03315	COG1404	Belongs to the peptidase S8 family
HFZ78_03330	COG0183	Belongs to the thiolase family
HFZ78_03335	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_03340	COG1268	BioY protein
HFZ78_03365	COG0778	Nitroreductase
HFZ78_03385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFZ78_03390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HFZ78_03395	COG4853	Protein conserved in bacteria
HFZ78_03400	COG4863	YycH protein
HFZ78_03405	COG5002	protein histidine kinase activity
HFZ78_03410	COG0745	RESPONSE REGULATOR receiver
HFZ78_03450	COG0305	Participates in initiation and elongation during chromosome replication
HFZ78_03460	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HFZ78_03470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HFZ78_03475	COG0629	single-stranded DNA binding
HFZ78_03480	COG0360	Binds together with S18 to 16S ribosomal RNA
HFZ78_03485	COG0012	GTP binding
HFZ78_03495	COG0243	molybdopterin cofactor binding
HFZ78_03500	COG4481	Protein conserved in bacteria
HFZ78_03505	COG0668	transmembrane transport
HFZ78_03520	COG1475	DNA binding
HFZ78_03525	COG1192	Involved in chromosome partitioning
HFZ78_03530	COG1475	DNA binding
HFZ78_03540	COG0445	tRNA wobble uridine modification
HFZ78_03545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HFZ78_03550	COG1847	R3H domain protein
HFZ78_03560	COG0594	ribonuclease P activity
HFZ78_03575	COG0592	DNA-directed DNA polymerase activity
HFZ78_03580	COG2501	S4 domain
HFZ78_03585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HFZ78_03595	COG0187	DNA topoisomerase II activity
HFZ78_03600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HFZ78_03635	COG0517	IMP dehydrogenase activity
HFZ78_03635	COG0516	GMP reductase activity
HFZ78_03650	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HFZ78_03665	COG1428	Deoxynucleoside kinase
HFZ78_03670	COG1428	Deoxynucleoside kinase
HFZ78_03675	COG1388	LysM domain
HFZ78_03675	COG3858	chitin binding
HFZ78_03680	COG1335	isochorismatase
HFZ78_03685	COG0590	tRNA wobble adenosine to inosine editing
HFZ78_03695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HFZ78_03700	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HFZ78_03705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HFZ78_03750	COG1982	Orn Lys Arg decarboxylase major
HFZ78_03755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HFZ78_03760	COG3870	Protein conserved in bacteria
HFZ78_03765	COG0470	DNA polymerase III
HFZ78_03770	COG1774	PSP1 C-terminal conserved region
HFZ78_03775	COG4467	Involved in initiation control of chromosome replication
HFZ78_03780	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HFZ78_03790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HFZ78_03795	COG2002	toxin-antitoxin pair type II binding
HFZ78_03805	COG0084	hydrolase, TatD family'
HFZ78_03810	COG3583	domain protein
HFZ78_03810	COG3584	3D domain protein
HFZ78_03820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HFZ78_03830	COG4466	Protein conserved in bacteria
HFZ78_03845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HFZ78_03850	COG0251	oxidation-reduction process
HFZ78_03855	COG2088	sporulation resulting in formation of a cellular spore
HFZ78_03860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HFZ78_03870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HFZ78_03875	COG0193	aminoacyl-tRNA hydrolase activity
HFZ78_03885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HFZ78_03890	COG2002	toxin-antitoxin pair type II binding
HFZ78_03895	COG2244	polysaccharide biosynthetic process
HFZ78_03900	COG3956	TIGRFAM MazG family protein
HFZ78_03905	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HFZ78_03925	COG1098	S1 RNA binding domain
HFZ78_03930	COG2208	phosphoserine phosphatase activity
HFZ78_03935	COG2304	oxidoreductase activity
HFZ78_03940	COG0515	serine threonine protein kinase
HFZ78_03955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFZ78_03960	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HFZ78_03965	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HFZ78_03970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFZ78_03975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HFZ78_03980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HFZ78_03985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HFZ78_03990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFZ78_03995	COG1396	sequence-specific DNA binding
HFZ78_04000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFZ78_04090	COG3880	PFAM UvrB UvrC protein
HFZ78_04095	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HFZ78_04100	COG0542	response to heat
HFZ78_04105	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HFZ78_04115	COG4956	integral membrane protein (PIN domain superfamily)
HFZ78_04120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HFZ78_04125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HFZ78_04130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFZ78_04135	COG1045	serine acetyltransferase
HFZ78_04140	COG0215	cysteine-tRNA ligase activity
HFZ78_04150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFZ78_04155	COG3688	RNA-binding protein containing a PIN domain
HFZ78_04165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFZ78_04170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HFZ78_04175	COG0250	Participates in transcription elongation, termination and antitermination
HFZ78_04180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HFZ78_04185	COG0081	regulation of translation
HFZ78_04190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HFZ78_04195	COG0222	ribosome binding
HFZ78_04200	COG2813	Specifically methylates the guanine in position
HFZ78_04215	COG1358	cellular component organization or biogenesis
HFZ78_04220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HFZ78_04225	COG0049	tRNA binding
HFZ78_04230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HFZ78_04235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HFZ78_04245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HFZ78_04250	COG0088	Forms part of the polypeptide exit tunnel
HFZ78_04260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HFZ78_04275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HFZ78_04280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HFZ78_04295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HFZ78_04300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HFZ78_04320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HFZ78_04330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HFZ78_04335	COG1841	ribosomal large subunit assembly
HFZ78_04345	COG0201	protein transport
HFZ78_04350	COG0563	adenylate kinase activity
HFZ78_04355	COG0024	Methionine aminopeptidase
HFZ78_04360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HFZ78_04365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HFZ78_04370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HFZ78_04375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HFZ78_04380	COG0202	RNA polymerase activity
HFZ78_04385	COG0203	ribosomal protein L17
HFZ78_04390	COG1122	ATPase activity
HFZ78_04395	COG1122	ATPase activity
HFZ78_04400	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HFZ78_04405	COG0101	tRNA pseudouridine synthase activity
HFZ78_04410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HFZ78_04415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HFZ78_04430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HFZ78_04440	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HFZ78_04445	COG0535	radical SAM domain protein
HFZ78_04455	COG0517	IMP dehydrogenase activity
HFZ78_04465	COG1027	Aspartate ammonia-lyase
HFZ78_04470	COG4191	Histidine kinase
HFZ78_04475	COG0784	Response regulator, receiver
HFZ78_04485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HFZ78_04505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_04515	COG2197	response regulator
HFZ78_04520	COG2203	Gaf domain
HFZ78_04520	COG4585	Histidine kinase
HFZ78_04525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HFZ78_04530	COG0300	oxidoreductase activity
HFZ78_04545	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFZ78_04550	COG0489	protein tyrosine kinase activity
HFZ78_04560	COG2194	sulfuric ester hydrolase activity
HFZ78_04565	COG0726	polysaccharide deacetylase
HFZ78_04635	COG1595	DNA-templated transcription, initiation
HFZ78_04640	COG5662	AntiSigma factor
HFZ78_04645	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HFZ78_04650	COG4856	YbbR-like protein
HFZ78_04655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFZ78_04660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HFZ78_04670	COG3711	transcriptional antiterminator
HFZ78_04675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_04685	COG5002	protein histidine kinase activity
HFZ78_04690	COG1846	Transcriptional regulator
HFZ78_04695	COG2259	Doxx family
HFZ78_04700	COG0346	lactoylglutathione lyase activity
HFZ78_04705	COG0346	lactoylglutathione lyase activity
HFZ78_04710	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HFZ78_04725	COG4555	ABC transporter
HFZ78_04740	COG1309	transcriptional regulator
HFZ78_04755	COG0018	arginyl-trna synthetase
HFZ78_04765	COG0531	amino acid
HFZ78_04775	COG0586	Pfam SNARE associated Golgi protein
HFZ78_04780	COG2239	Acts as a magnesium transporter
HFZ78_04795	COG1181	Belongs to the D-alanine--D-alanine ligase family
HFZ78_04800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HFZ78_04810	COG4294	response to UV
HFZ78_04815	COG3402	PFAM membrane-flanked domain
HFZ78_04820	COG3428	Bacterial PH domain
HFZ78_04825	COG0705	Rhomboid family
HFZ78_04830	COG0736	holo-[acyl-carrier-protein] synthase activity
HFZ78_04835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HFZ78_04845	COG0864	Transcriptional regulator
HFZ78_04850	COG2337	Toxic component of a toxin-antitoxin (TA) module
HFZ78_04855	COG2183	response to ionizing radiation
HFZ78_04865	COG3091	SprT-like family
HFZ78_04940	COG0802	atpase or kinase
HFZ78_04945	COG1214	PFAM Peptidase M22, glycoprotease
HFZ78_04950	COG0456	acetyltransferase
HFZ78_04960	COG0488	(ABC) transporter
HFZ78_04965	COG0315	cyclic pyranopterin monophosphate synthase activity
HFZ78_04970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HFZ78_04975	COG0281	malic enzyme
HFZ78_04980	COG0730	response to heat
HFZ78_04985	COG3290	protein histidine kinase activity
HFZ78_04990	COG4565	transcriptional regulatory protein
HFZ78_04995	COG3493	citrate carrier protein
HFZ78_05000	COG0281	malic enzyme
HFZ78_05005	COG0789	Transcriptional regulator
HFZ78_05010	COG1664	Polymer-forming cytoskeletal
HFZ78_05015	COG1664	Polymer-forming cytoskeletal
HFZ78_05020	COG2814	Major facilitator Superfamily
HFZ78_05030	COG1266	CAAX protease self-immunity
HFZ78_05040	COG0459	protein refolding
HFZ78_05045	COG1486	melibiose metabolic process
HFZ78_05060	COG1175	transmembrane transport
HFZ78_05065	COG0395	ABC-type sugar transport system, permease component
HFZ78_05085	COG3459	Glycosyltransferase 36 associated
HFZ78_05090	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ78_05095	COG1607	acyl-coa hydrolase
HFZ78_05105	COG4191	Histidine kinase
HFZ78_05115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_05120	COG1115	amino acid carrier protein
HFZ78_05125	COG0517	IMP dehydrogenase activity
HFZ78_05135	COG1819	glycosyl
HFZ78_05150	COG0457	Tetratricopeptide repeat
HFZ78_05155	COG1063	alcohol dehydrogenase
HFZ78_05160	COG2211	Major facilitator Superfamily
HFZ78_05165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_05255	COG0714	Associated with various cellular activities
HFZ78_05260	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HFZ78_05265	COG1305	Transglutaminase-like
HFZ78_05270	COG0519	Catalyzes the synthesis of GMP from XMP
HFZ78_05270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFZ78_05275	COG2252	PERMEase
HFZ78_05280	COG3711	transcriptional antiterminator
HFZ78_05285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_05285	COG1263	PTS System
HFZ78_05285	COG2190	(PTS) system
HFZ78_05305	COG0668	transmembrane transport
HFZ78_05315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HFZ78_05320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFZ78_05325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFZ78_05330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HFZ78_05335	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFZ78_05340	COG0047	phosphoribosylformylglycinamidine synthase activity
HFZ78_05350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HFZ78_05360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFZ78_05370	COG0151	Belongs to the GarS family
HFZ78_05385	COG1470	cell adhesion involved in biofilm formation
HFZ78_05390	COG4496	protein, YerC YecD
HFZ78_05395	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HFZ78_05400	COG0210	DNA helicase
HFZ78_05405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HFZ78_05410	COG4851	CamS sex pheromone cAM373 precursor
HFZ78_05415	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_05440	COG2146	nitrite reductase [NAD(P)H] activity
HFZ78_05445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFZ78_05445	COG1587	Uroporphyrinogen-III synthase
HFZ78_05455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HFZ78_05460	COG2224	Isocitrate lyase
HFZ78_05465	COG5506	Protein of unknown function (DUF1694)
HFZ78_05470	COG1764	response to oxidative stress
HFZ78_05480	COG0741	lytic transglycosylase activity
HFZ78_05485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFZ78_05490	COG0154	amidase activity
HFZ78_05495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFZ78_05500	COG0346	lactoylglutathione lyase activity
HFZ78_05510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_05525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFZ78_05555	COG1597	lipid kinase activity
HFZ78_05560	COG1335	isochorismatase
HFZ78_05565	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HFZ78_05590	COG0791	NLP P60 protein
HFZ78_05590	COG1388	LysM domain
HFZ78_05615	COG5002	protein histidine kinase activity
HFZ78_05620	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HFZ78_05630	COG2197	response regulator
HFZ78_05650	COG1268	BioY protein
HFZ78_05655	COG2972	Histidine kinase
HFZ78_05660	COG4753	response regulator
HFZ78_05660	COG2207	Transcriptional regulator
HFZ78_05665	COG1653	transport
HFZ78_05675	COG0395	ABC-type sugar transport system, permease component
HFZ78_05680	COG5578	integral membrane protein
HFZ78_05685	COG3507	Belongs to the glycosyl hydrolase 43 family
HFZ78_05695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_05700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_05705	COG1120	ATPase activity
HFZ78_05725	COG2235	arginine
HFZ78_05735	COG0833	amino acid
HFZ78_05740	COG4187	Peptidase family M20/M25/M40
HFZ78_05745	COG1785	Belongs to the alkaline phosphatase family
HFZ78_05760	COG4753	response regulator
HFZ78_05760	COG2207	Transcriptional regulator
HFZ78_05765	COG2972	Histidine kinase
HFZ78_05785	COG3250	beta-galactosidase activity
HFZ78_05795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HFZ78_05800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFZ78_05805	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HFZ78_05810	COG2017	converts alpha-aldose to the beta-anomer
HFZ78_05815	COG1609	Transcriptional regulator
HFZ78_05825	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_05830	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_05840	COG2972	Histidine kinase
HFZ78_05845	COG2201	protein-glutamate methylesterase activity
HFZ78_05855	COG1129	ABC transporter
HFZ78_05860	COG4211	Belongs to the binding-protein-dependent transport system permease family
HFZ78_05875	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_05880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_05885	COG2610	gluconate transmembrane transporter activity
HFZ78_05890	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_05895	COG3290	protein histidine kinase activity
HFZ78_05895	COG3829	transcription factor binding
HFZ78_05900	COG1132	(ABC) transporter
HFZ78_05910	COG5002	protein histidine kinase activity
HFZ78_05925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFZ78_05930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HFZ78_05935	COG1823	symporter activity
HFZ78_05940	COG2514	catechol 2,3-dioxygenase activity
HFZ78_05965	COG2972	Histidine kinase
HFZ78_05975	COG4753	response regulator
HFZ78_05975	COG2207	Transcriptional regulator
HFZ78_05985	COG1175	transmembrane transport
HFZ78_05990	COG0395	ABC-type sugar transport system, permease component
HFZ78_06005	COG3250	beta-galactosidase activity
HFZ78_06010	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFZ78_06025	COG0671	phosphoesterase, PA-phosphatase related
HFZ78_06030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HFZ78_06060	COG5002	protein histidine kinase activity
HFZ78_06065	COG0561	phosphatase activity
HFZ78_06070	COG1609	Transcriptional regulator
HFZ78_06150	COG1609	Transcriptional regulator
HFZ78_06155	COG0366	Alpha amylase catalytic
HFZ78_06160	COG1653	transport
HFZ78_06165	COG1175	transmembrane transport
HFZ78_06170	COG0395	ABC-type sugar transport system, permease component
HFZ78_06175	COG1063	alcohol dehydrogenase
HFZ78_06180	COG1082	Xylose isomerase domain protein TIM barrel
HFZ78_06185	COG0673	inositol 2-dehydrogenase activity
HFZ78_06190	COG1554	hydrolase, family 65, central catalytic
HFZ78_06195	COG1929	Belongs to the glycerate kinase type-1 family
HFZ78_06200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFZ78_06220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HFZ78_06230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_06270	COG1216	Glycosyl transferase, family 2
HFZ78_06295	COG2046	Belongs to the sulfate adenylyltransferase family
HFZ78_06300	COG0730	response to heat
HFZ78_06310	COG0438	transferase activity, transferring glycosyl groups
HFZ78_06325	COG1086	Polysaccharide biosynthesis protein
HFZ78_06340	COG3239	Fatty acid desaturase
HFZ78_06345	COG2197	response regulator
HFZ78_06350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HFZ78_06400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_06415	COG1609	Transcriptional regulator
HFZ78_06420	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HFZ78_06425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HFZ78_06430	COG2824	Alkylphosphonate utilization operon protein PhnA
HFZ78_06440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HFZ78_06450	COG2323	membrane
HFZ78_06455	COG0025	NhaP-type Na H and K H
HFZ78_06460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFZ78_06480	COG0347	Belongs to the P(II) protein family
HFZ78_06485	COG0004	ammonium transporteR
HFZ78_06490	COG1988	membrane-bound metal-dependent
HFZ78_06495	COG0438	transferase activity, transferring glycosyl groups
HFZ78_06500	COG1785	Belongs to the alkaline phosphatase family
HFZ78_06520	COG2508	Transcriptional regulator
HFZ78_06530	COG1228	amidohydrolase
HFZ78_06540	COG0402	S-adenosylhomocysteine deaminase activity
HFZ78_06545	COG1953	Uracil, thiamine, allantoin
HFZ78_06555	COG4753	response regulator
HFZ78_06555	COG2207	Transcriptional regulator
HFZ78_06560	COG2972	Histidine kinase
HFZ78_06565	COG4608	Belongs to the ABC transporter superfamily
HFZ78_06570	COG0444	Belongs to the ABC transporter superfamily
HFZ78_06590	COG0402	S-adenosylhomocysteine deaminase activity
HFZ78_06595	COG0402	S-adenosylhomocysteine deaminase activity
HFZ78_06600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HFZ78_06605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ78_06610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HFZ78_06630	COG2267	carboxylic ester hydrolase activity
HFZ78_06635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HFZ78_06650	COG0673	inositol 2-dehydrogenase activity
HFZ78_06665	COG3123	guanosine phosphorylase activity
HFZ78_06690	COG1473	amidohydrolase
HFZ78_06695	COG1473	amidohydrolase
HFZ78_06715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFZ78_06740	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HFZ78_06745	COG1309	transcriptional regulator
HFZ78_06765	COG0604	alcohol dehydrogenase
HFZ78_06790	COG2271	Major facilitator Superfamily
HFZ78_06800	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_06805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFZ78_06810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFZ78_06815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HFZ78_06815	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HFZ78_06820	COG1447	Phosphotransferase system cellobiose-specific component IIA
HFZ78_06830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFZ78_06835	COG2723	6-phospho-beta-galactosidase activity
HFZ78_06840	COG4191	Histidine kinase
HFZ78_06870	COG1414	Transcriptional regulator
HFZ78_06880	COG2721	sulfolactate sulfo-lyase activity
HFZ78_06885	COG2721	sulfolactate sulfo-lyase activity
HFZ78_06895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFZ78_06900	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_06915	COG0861	Integral membrane protein TerC family
HFZ78_06930	COG1335	isochorismatase
HFZ78_06960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HFZ78_06975	COG0531	amino acid
HFZ78_06980	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HFZ78_06985	COG1309	transcriptional regulator
HFZ78_06990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_07005	COG2368	4-hydroxyphenylacetate
HFZ78_07025	COG0196	riboflavin kinase activity
HFZ78_07030	COG0477	Major facilitator Superfamily
HFZ78_07040	COG0531	amino acid
HFZ78_07060	COG0531	amino acid
HFZ78_07065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_07075	COG3829	transcription factor binding
HFZ78_07075	COG3290	protein histidine kinase activity
HFZ78_07080	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_07090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFZ78_07095	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_07100	COG1879	ABC-type sugar transport system periplasmic component
HFZ78_07105	COG1129	ABC transporter
HFZ78_07110	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ78_07115	COG1070	Carbohydrate kinase
HFZ78_07120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_07125	COG2188	Transcriptional regulator
HFZ78_07140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ78_07145	COG0697	spore germination
HFZ78_07150	COG3118	belongs to the thioredoxin family
HFZ78_07155	COG0583	DNA-binding transcription factor activity
HFZ78_07170	COG3964	amidohydrolase
HFZ78_07190	COG2188	Transcriptional regulator
HFZ78_07200	COG0693	protein deglycase activity
HFZ78_07230	COG0579	oxidoreductase
HFZ78_07250	COG0534	Mate efflux family protein
HFZ78_07255	COG3773	Cell wall hydrolase
HFZ78_07270	COG1764	response to oxidative stress
HFZ78_07280	COG2323	membrane
HFZ78_07315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HFZ78_07325	COG1349	DNA-binding transcription factor activity
HFZ78_07355	COG1595	DNA-templated transcription, initiation
HFZ78_07370	COG1960	acyl-CoA dehydrogenase activity
HFZ78_07380	COG0196	riboflavin kinase activity
HFZ78_07385	COG3384	dioxygenase
HFZ78_07405	COG2807	transmembrane transport
HFZ78_07435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_07455	COG4191	Histidine kinase
HFZ78_07460	COG0784	Response regulator, receiver
HFZ78_07465	COG0281	malic enzyme
HFZ78_07475	COG5002	protein histidine kinase activity
HFZ78_07505	COG2132	Multicopper oxidase
HFZ78_07525	COG2720	vancomycin resistance protein
HFZ78_07535	COG0697	spore germination
HFZ78_07555	COG1070	Carbohydrate kinase
HFZ78_07560	COG0477	Major facilitator Superfamily
HFZ78_07560	COG2814	Major facilitator Superfamily
HFZ78_07570	COG1940	carbohydrate kinase activity
HFZ78_07575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFZ78_07580	COG2340	Cysteine-rich secretory protein family
HFZ78_07620	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HFZ78_07625	COG0656	L-ascorbic acid biosynthetic process
HFZ78_07630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HFZ78_07660	COG2814	Major facilitator Superfamily
HFZ78_07670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ78_07675	COG2267	carboxylic ester hydrolase activity
HFZ78_07700	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HFZ78_07710	COG4208	sulfate ABC transporter
HFZ78_07730	COG1070	Carbohydrate kinase
HFZ78_07760	COG3347	Dehydrogenase
HFZ78_07760	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_07765	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HFZ78_07775	COG1070	Carbohydrate kinase
HFZ78_07785	COG2258	MOSC domain
HFZ78_07805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_07810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFZ78_07830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFZ78_07860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HFZ78_07885	COG0640	Transcriptional regulator
HFZ78_07890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_07895	COG1309	transcriptional regulator
HFZ78_07925	COG0346	lactoylglutathione lyase activity
HFZ78_07930	COG2076	Multidrug Resistance protein
HFZ78_07935	COG2076	Multidrug Resistance protein
HFZ78_07960	COG2972	Histidine kinase
HFZ78_07965	COG2207	Transcriptional regulator
HFZ78_07965	COG4753	response regulator
HFZ78_07975	COG4753	response regulator
HFZ78_07975	COG2207	Transcriptional regulator
HFZ78_07995	COG4209	transmembrane transport
HFZ78_08000	COG0395	ABC-type sugar transport system, permease component
HFZ78_08010	COG1621	beta-fructofuranosidase activity
HFZ78_08015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_08020	COG0561	phosphatase activity
HFZ78_08025	COG1609	Transcriptional regulator
HFZ78_08030	COG4209	transmembrane transport
HFZ78_08035	COG0395	ABC-type sugar transport system, permease component
HFZ78_08040	COG1653	transport
HFZ78_08045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_08055	COG1621	beta-fructofuranosidase activity
HFZ78_08065	COG1621	beta-fructofuranosidase activity
HFZ78_08070	COG1621	beta-fructofuranosidase activity
HFZ78_08085	COG1621	beta-fructofuranosidase activity
HFZ78_08090	COG1263	PTS System
HFZ78_08090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_08095	COG3711	transcriptional antiterminator
HFZ78_08105	COG1609	Transcriptional regulator
HFZ78_08110	COG0673	inositol 2-dehydrogenase activity
HFZ78_08115	COG2207	Transcriptional regulator
HFZ78_08125	COG0673	inositol 2-dehydrogenase activity
HFZ78_08140	COG0366	Alpha amylase catalytic
HFZ78_08145	COG1609	Transcriptional regulator
HFZ78_08150	COG1653	transport
HFZ78_08155	COG1175	transmembrane transport
HFZ78_08160	COG0395	ABC-type sugar transport system, permease component
HFZ78_08180	COG0385	Bile acid
HFZ78_08200	COG0590	tRNA wobble adenosine to inosine editing
HFZ78_08205	COG2068	MobA-Related Protein
HFZ78_08215	COG3648	Uricase
HFZ78_08215	COG3195	allantoin biosynthetic process
HFZ78_08220	COG2351	hydroxyisourate hydrolase activity
HFZ78_08225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HFZ78_08230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ78_08235	COG0831	urea catabolic process
HFZ78_08240	COG0832	Belongs to the urease beta subunit family
HFZ78_08250	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HFZ78_08255	COG0830	nickel cation binding
HFZ78_08265	COG0829	nickel cation binding
HFZ78_08285	COG0166	Belongs to the GPI family
HFZ78_08290	COG3189	MarR family transcriptional regulator
HFZ78_08305	COG5434	Belongs to the glycosyl hydrolase 28 family
HFZ78_08320	COG0456	acetyltransferase
HFZ78_08325	COG0066	3-isopropylmalate dehydratase activity
HFZ78_08330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HFZ78_08335	COG0473	3-isopropylmalate dehydrogenase activity
HFZ78_08340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFZ78_08345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HFZ78_08350	COG0440	acetolactate synthase activity
HFZ78_08355	COG0028	Belongs to the TPP enzyme family
HFZ78_08360	COG0129	dihydroxy-acid dehydratase activity
HFZ78_08365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFZ78_08370	COG2176	DNA-directed DNA polymerase activity
HFZ78_08380	COG0004	ammonium transporteR
HFZ78_08385	COG0789	Transcriptional regulator
HFZ78_08410	COG0765	amino acid transport
HFZ78_08430	COG1960	acyl-CoA dehydrogenase activity
HFZ78_08440	COG1690	Belongs to the RtcB family
HFZ78_08450	COG2814	Major facilitator Superfamily
HFZ78_08460	COG3829	transcription factor binding
HFZ78_08460	COG3290	protein histidine kinase activity
HFZ78_08475	COG0183	Belongs to the thiolase family
HFZ78_08485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFZ78_08495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFZ78_08500	COG0514	ATP-dependent DNA helicase (RecQ)
HFZ78_08505	COG2116	formate transmembrane transporter activity
HFZ78_08510	COG0535	radical SAM domain protein
HFZ78_08520	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_08525	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFZ78_08530	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFZ78_08535	COG2271	Major facilitator Superfamily
HFZ78_08545	COG1129	ABC transporter
HFZ78_08550	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ78_08560	COG2222	sugar isomerase
HFZ78_08565	COG1653	transport
HFZ78_08570	COG1175	transmembrane transport
HFZ78_08575	COG0395	ABC-type sugar transport system, permease component
HFZ78_08580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_08585	COG2188	Transcriptional regulator
HFZ78_08590	COG2966	Psort location CytoplasmicMembrane, score
HFZ78_08595	COG3610	response to peptide
HFZ78_08600	COG4990	cell redox homeostasis
HFZ78_08605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFZ78_08635	COG3275	phosphorelay sensor kinase activity
HFZ78_08640	COG3279	Response regulator of the LytR AlgR family
HFZ78_08645	COG1966	Carbon starvation protein
HFZ78_08650	COG0531	amino acid
HFZ78_08655	COG5002	protein histidine kinase activity
HFZ78_08660	COG3437	response regulator, receiver
HFZ78_08675	COG0243	molybdopterin cofactor binding
HFZ78_08710	COG2197	response regulator
HFZ78_08730	COG0673	inositol 2-dehydrogenase activity
HFZ78_08735	COG0348	domain, Protein
HFZ78_08760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_08770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_08780	COG0513	Belongs to the DEAD box helicase family
HFZ78_08785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ78_08785	COG0723	plastoquinol--plastocyanin reductase activity
HFZ78_08800	COG2340	Cysteine-rich secretory protein family
HFZ78_08810	COG1842	Phage shock protein A
HFZ78_08825	COG2197	response regulator
HFZ78_08840	COG2244	polysaccharide biosynthetic process
HFZ78_08850	COG3186	Phenylalanine-4-hydroxylase
HFZ78_08855	COG0670	Belongs to the BI1 family
HFZ78_08865	COG2309	aminopeptidase activity
HFZ78_08875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HFZ78_08875	COG0551	DNA topoisomerase type I activity
HFZ78_08880	COG2986	histidine ammonia-lyase
HFZ78_08895	COG1396	sequence-specific DNA binding
HFZ78_08900	COG0024	Methionine aminopeptidase
HFZ78_08905	COG4840	Belongs to the UPF0435 family
HFZ78_08915	COG1295	ribonuclease BN
HFZ78_08920	COG2217	Heavy metal translocating P-type atpase
HFZ78_08925	COG0477	Major facilitator Superfamily
HFZ78_08930	COG0387	Pfam Sodium calcium exchanger
HFZ78_08935	COG2364	Membrane
HFZ78_08965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HFZ78_08970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFZ78_08975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFZ78_08990	COG0531	amino acid
HFZ78_09005	COG0569	domain protein
HFZ78_09010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFZ78_09045	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFZ78_09050	COG0667	Aldo Keto reductase
HFZ78_09055	COG0778	Nitroreductase
HFZ78_09075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HFZ78_09110	COG0697	spore germination
HFZ78_09140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFZ78_09165	COG0640	Transcriptional regulator
HFZ78_09190	COG4807	Protein conserved in bacteria
HFZ78_09195	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HFZ78_09205	COG1414	Transcriptional regulator
HFZ78_09215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFZ78_09220	COG2610	gluconate transmembrane transporter activity
HFZ78_09230	COG1846	Transcriptional regulator
HFZ78_09235	COG0386	Belongs to the glutathione peroxidase family
HFZ78_09255	COG0322	excinuclease ABC activity
HFZ78_09260	COG3104	oligopeptide transport
HFZ78_09265	COG0789	Transcriptional regulator
HFZ78_09270	COG0444	Belongs to the ABC transporter superfamily
HFZ78_09275	COG4608	Belongs to the ABC transporter superfamily
HFZ78_09280	COG0747	negative chemotaxis
HFZ78_09295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HFZ78_09300	COG0710	3-dehydroquinate dehydratase activity
HFZ78_09310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HFZ78_09315	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HFZ78_09320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HFZ78_09325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFZ78_09330	COG0505	Belongs to the CarA family
HFZ78_09335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HFZ78_09340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HFZ78_09345	COG0137	argininosuccinate synthase activity
HFZ78_09350	COG0165	Argininosuccinate lyase
HFZ78_09355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFZ78_09355	COG3153	acetyltransferase
HFZ78_09360	COG0456	acetyltransferase
HFZ78_09370	COG0460	homoserine dehydrogenase
HFZ78_09385	COG1090	epimerase
HFZ78_09390	COG2137	regulation of response to DNA damage stimulus
HFZ78_09415	COG1988	membrane-bound metal-dependent
HFZ78_09420	COG1194	a g-specific adenine glycosylase
HFZ78_09430	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_09450	COG1132	(ABC) transporter
HFZ78_09455	COG4129	membrane
HFZ78_09460	COG0067	glutamate synthase
HFZ78_09460	COG0069	glutamate synthase activity
HFZ78_09460	COG0070	glutamate synthase
HFZ78_09465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HFZ78_09470	COG4555	ABC transporter
HFZ78_09490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFZ78_09495	COG0735	belongs to the Fur family
HFZ78_09610	COG3382	B3 4 domain protein
HFZ78_09615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HFZ78_09625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HFZ78_09630	COG0778	Nitroreductase
HFZ78_09635	COG2766	serine protein kinase
HFZ78_09645	COG3142	Participates in the control of copper homeostasis
HFZ78_09655	COG0784	Response regulator, receiver
HFZ78_09660	COG4191	Histidine kinase
HFZ78_09670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_09670	COG2190	(PTS) system
HFZ78_09670	COG1263	PTS System
HFZ78_09675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HFZ78_09680	COG0363	glucosamine-6-phosphate deaminase activity
HFZ78_09685	COG2188	Transcriptional regulator
HFZ78_09690	COG4821	SIS domain
HFZ78_09695	COG2340	Cysteine-rich secretory protein family
HFZ78_09700	COG5002	protein histidine kinase activity
HFZ78_09705	COG5001	Diguanylate cyclase
HFZ78_09705	COG4251	negative regulation of phosphorylation
HFZ78_09705	COG2203	Gaf domain
HFZ78_09705	COG3706	GGDEF domain
HFZ78_09715	COG2211	Major facilitator Superfamily
HFZ78_09720	COG2211	Major facilitator Superfamily
HFZ78_09725	COG1940	carbohydrate kinase activity
HFZ78_09730	COG1904	glucuronate isomerase
HFZ78_09735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HFZ78_09750	COG0673	inositol 2-dehydrogenase activity
HFZ78_09765	COG1940	carbohydrate kinase activity
HFZ78_09780	COG1606	tRNA processing
HFZ78_09785	COG1070	Carbohydrate kinase
HFZ78_09790	COG1691	(AIR) carboxylase
HFZ78_09795	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HFZ78_09800	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HFZ78_09805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HFZ78_09815	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HFZ78_09825	COG2409	Drug exporters of the RND superfamily
HFZ78_09830	COG2390	Transcriptional regulator
HFZ78_09835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HFZ78_09875	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_09900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HFZ78_09905	COG0745	RESPONSE REGULATOR receiver
HFZ78_09925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_09930	COG0306	phosphate transporter
HFZ78_09935	COG1392	Phosphate transport regulator
HFZ78_09940	COG2261	transglycosylase associated protein
HFZ78_09945	COG0564	pseudouridine synthase activity
HFZ78_09955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFZ78_09970	COG2719	SpoVR family
HFZ78_09975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFZ78_09975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFZ78_09980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFZ78_09980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFZ78_10010	COG1215	transferase activity, transferring glycosyl groups
HFZ78_10030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HFZ78_10035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HFZ78_10040	COG0686	Belongs to the AlaDH PNT family
HFZ78_10045	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HFZ78_10045	COG2508	Transcriptional regulator
HFZ78_10050	COG1113	amino acid transport
HFZ78_10060	COG1309	transcriptional regulator
HFZ78_10065	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HFZ78_10075	COG2733	membrane
HFZ78_10090	COG1253	flavin adenine dinucleotide binding
HFZ78_10095	COG1253	flavin adenine dinucleotide binding
HFZ78_10100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_10105	COG3852	Histidine kinase
HFZ78_10130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ78_10135	COG1132	(ABC) transporter
HFZ78_10140	COG1132	(ABC) transporter
HFZ78_10145	COG0702	epimerase
HFZ78_10165	COG3842	ATPase activity
HFZ78_10170	COG2508	Transcriptional regulator
HFZ78_10190	COG0189	ligase activity
HFZ78_10195	COG0189	ligase activity
HFZ78_10205	COG3679	Belongs to the UPF0342 family
HFZ78_10210	COG0561	phosphatase activity
HFZ78_10215	COG1024	Enoyl-CoA hydratase
HFZ78_10225	COG4152	abc transporter atp-binding protein
HFZ78_10230	COG1668	transmembrane transport
HFZ78_10235	COG0420	3'-5' exonuclease activity
HFZ78_10240	COG4717	serine-type aminopeptidase activity
HFZ78_10245	COG3481	metal-dependent phosphohydrolase, HD sub domain
HFZ78_10255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFZ78_10280	COG1846	Transcriptional regulator
HFZ78_10295	COG0537	adenosine 5'-monophosphoramidase activity
HFZ78_10300	COG1131	(ABC) transporter
HFZ78_10305	COG4473	ABC transporter
HFZ78_10315	COG1473	amidohydrolase
HFZ78_10325	COG3069	C4-dicarboxylate transmembrane transporter activity
HFZ78_10330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HFZ78_10345	COG1511	domain protein
HFZ78_10350	COG1234	tRNA 3'-trailer cleavage
HFZ78_10355	COG0095	Lipoate-protein ligase
HFZ78_10360	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_10365	COG0501	Belongs to the peptidase M48B family
HFZ78_10375	COG4903	ComK protein
HFZ78_10390	COG0398	Pfam SNARE associated Golgi protein
HFZ78_10400	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HFZ78_10470	COG0455	bacterial-type flagellum organization
HFZ78_10490	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_10515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HFZ78_10525	COG0367	asparagine synthase
HFZ78_10530	COG0366	Alpha amylase catalytic
HFZ78_10535	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_10540	COG1666	GTP binding
HFZ78_10545	COG2996	Protein conserved in bacteria
HFZ78_10555	COG1307	EDD domain protein, DegV family
HFZ78_10560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_10575	COG0561	phosphatase activity
HFZ78_10580	COG2151	metal-sulfur cluster biosynthetic enzyme
HFZ78_10590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_10595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HFZ78_10600	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HFZ78_10605	COG0303	'Molybdopterin
HFZ78_10610	COG1763	Mo-molybdopterin cofactor biosynthetic process
HFZ78_10620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_10630	COG0542	response to heat
HFZ78_10640	COG2267	carboxylic ester hydrolase activity
HFZ78_10650	COG1744	ABC transporter substrate-binding protein PnrA-like
HFZ78_10660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HFZ78_10665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ78_10670	COG5504	Zn-dependent protease
HFZ78_10675	COG0444	Belongs to the ABC transporter superfamily
HFZ78_10680	COG4608	Belongs to the ABC transporter superfamily
HFZ78_10685	COG0747	negative chemotaxis
HFZ78_10690	COG0601	transmembrane transport
HFZ78_10695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFZ78_10705	COG0180	Tryptophanyl-tRNA synthetase
HFZ78_10715	COG4166	transmembrane transport
HFZ78_10720	COG0601	transmembrane transport
HFZ78_10725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFZ78_10730	COG0444	Belongs to the ABC transporter superfamily
HFZ78_10735	COG4608	Belongs to the ABC transporter superfamily
HFZ78_10745	COG1393	Belongs to the ArsC family
HFZ78_10750	COG4862	establishment of competence for transformation
HFZ78_10755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFZ78_10765	COG1164	Oligoendopeptidase f
HFZ78_10775	COG2346	COG2346, Truncated hemoglobins
HFZ78_10780	COG4116	CYTH
HFZ78_10790	COG2357	RelA SpoT domain protein
HFZ78_10800	COG0564	pseudouridine synthase activity
HFZ78_10805	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HFZ78_10810	COG0569	domain protein
HFZ78_10810	COG0475	glutathione-regulated potassium exporter activity
HFZ78_10815	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HFZ78_10850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HFZ78_10870	COG0210	DNA helicase
HFZ78_10875	COG2153	protein acetylation
HFZ78_10880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HFZ78_10885	COG2382	esterase
HFZ78_10910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_10920	COG0183	Belongs to the thiolase family
HFZ78_10925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ78_10945	COG0456	acetyltransferase
HFZ78_10950	COG1509	lysine 2,3-aminomutase activity
HFZ78_10960	COG0833	amino acid
HFZ78_10965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HFZ78_10970	COG0109	protoheme IX farnesyltransferase activity
HFZ78_10980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFZ78_10985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFZ78_11000	COG1704	LemA family
HFZ78_11010	COG0628	permease
HFZ78_11015	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HFZ78_11045	COG5578	integral membrane protein
HFZ78_11050	COG1175	transmembrane transport
HFZ78_11065	COG2972	Histidine kinase
HFZ78_11080	COG1940	carbohydrate kinase activity
HFZ78_11085	COG2222	sugar isomerase
HFZ78_11095	COG1105	Belongs to the carbohydrate kinase PfkB family
HFZ78_11100	COG3684	Belongs to the aldolase LacD family
HFZ78_11105	COG0800	Aldolase
HFZ78_11115	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HFZ78_11120	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_11145	COG2211	Major facilitator Superfamily
HFZ78_11195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_11200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFZ78_11235	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFZ78_11240	COG2267	carboxylic ester hydrolase activity
HFZ78_11245	COG4585	Histidine kinase
HFZ78_11250	COG2197	response regulator
HFZ78_11255	COG2814	Major facilitator Superfamily
HFZ78_11260	COG2267	carboxylic ester hydrolase activity
HFZ78_11270	COG3850	Histidine kinase
HFZ78_11270	COG5002	protein histidine kinase activity
HFZ78_11275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HFZ78_11280	COG0512	Glutamine amidotransferase of anthranilate synthase
HFZ78_11285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFZ78_11290	COG3541	Predicted nucleotidyltransferase
HFZ78_11295	COG1276	copper resistance
HFZ78_11295	COG2372	response to copper ion
HFZ78_11305	COG2364	Membrane
HFZ78_11310	COG0436	Aminotransferase
HFZ78_11325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HFZ78_11345	COG1968	undecaprenyl-diphosphatase activity
HFZ78_11355	COG0584	glycerophosphoryl diester phosphodiesterase
HFZ78_11370	COG3339	Conserved Protein
HFZ78_11375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFZ78_11385	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HFZ78_11395	COG1191	sigma factor activity
HFZ78_11430	COG1620	l-lactate permease
HFZ78_11435	COG2186	Transcriptional regulator
HFZ78_11440	COG0247	lactate metabolic process
HFZ78_11445	COG1139	Iron-sulfur cluster binding protein
HFZ78_11450	COG1556	Lactate utilization protein
HFZ78_11460	COG0674	pyruvate-flavodoxin oxidoreductase activity
HFZ78_11470	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HFZ78_11475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFZ78_11480	COG0436	Aminotransferase
HFZ78_11485	COG1850	ribulose-bisphosphate carboxylase activity
HFZ78_11490	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HFZ78_11495	COG0235	Class ii aldolase
HFZ78_11500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HFZ78_11520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFZ78_11525	COG0644	oxidoreductase
HFZ78_11540	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HFZ78_11545	COG2223	nitrite transmembrane transporter activity
HFZ78_11550	COG1846	Transcriptional regulator
HFZ78_11560	COG0542	response to heat
HFZ78_11565	COG3949	Membrane
HFZ78_11575	COG4873	Protein conserved in bacteria
HFZ78_11590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFZ78_11605	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_11615	COG2084	Dehydrogenase
HFZ78_11625	COG0436	Aminotransferase
HFZ78_11640	COG1408	metallophosphoesterase
HFZ78_11645	COG4990	cell redox homeostasis
HFZ78_11650	COG2200	EAL domain
HFZ78_11655	COG4703	Protein of unknown function (DUF1797)
HFZ78_11660	COG0517	IMP dehydrogenase activity
HFZ78_11665	COG0477	Major facilitator Superfamily
HFZ78_11670	COG0583	DNA-binding transcription factor activity
HFZ78_11675	COG2171	N-acyltransferase activity
HFZ78_11680	COG1473	amidohydrolase
HFZ78_11685	COG0450	alkyl hydroperoxide reductase
HFZ78_11690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_11700	COG0569	domain protein
HFZ78_11705	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HFZ78_11715	COG0561	phosphatase activity
HFZ78_11770	COG1982	Orn Lys Arg decarboxylase major
HFZ78_11780	COG4476	Belongs to the UPF0223 family
HFZ78_11785	COG4493	Belongs to the UPF0637 family
HFZ78_11795	COG0483	inositol monophosphate 1-phosphatase activity
HFZ78_11820	COG4896	Protein conserved in bacteria
HFZ78_11835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HFZ78_11840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HFZ78_11845	COG4838	Belongs to the UPF0358 family
HFZ78_11850	COG0772	Belongs to the SEDS family
HFZ78_11855	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HFZ78_11860	COG1612	heme a metabolic process
HFZ78_11865	COG0109	protoheme IX farnesyltransferase activity
HFZ78_11890	COG3336	cytochrome c oxidase
HFZ78_11905	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HFZ78_11910	COG2340	Cysteine-rich secretory protein family
HFZ78_11940	COG3679	Belongs to the UPF0342 family
HFZ78_11945	COG4471	UPF0298 protein
HFZ78_11955	COG0742	ribosomal rna small subunit methyltransferase
HFZ78_11960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HFZ78_11965	COG3314	Sporulation integral membrane protein YlbJ
HFZ78_11970	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFZ78_11975	COG3480	Lon protease (S16) C-terminal proteolytic domain
HFZ78_11980	COG1323	Belongs to the UPF0348 family
HFZ78_11985	COG1399	metal-binding, possibly nucleic acid-binding protein
HFZ78_11995	COG1024	Enoyl-CoA hydratase
HFZ78_12005	COG0454	-acetyltransferase
HFZ78_12010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFZ78_12015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HFZ78_12025	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HFZ78_12030	COG2001	Belongs to the MraZ family
HFZ78_12040	COG4839	cell division protein FtsL
HFZ78_12050	COG0768	penicillin binding
HFZ78_12065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HFZ78_12070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HFZ78_12075	COG0772	Belongs to the SEDS family
HFZ78_12080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HFZ78_12085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HFZ78_12090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HFZ78_12095	COG3879	Bacterial protein of unknown function (DUF881)
HFZ78_12100	COG3879	Bacterial protein of unknown function (DUF881)
HFZ78_12105	COG3856	small basic protein
HFZ78_12110	COG0849	cell division
HFZ78_12115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFZ78_12125	COG1191	sigma factor activity
HFZ78_12130	COG1191	sigma factor activity
HFZ78_12135	COG1873	PFAM PRC-barrel domain
HFZ78_12145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HFZ78_12150	COG1799	cell septum assembly
HFZ78_12155	COG0762	integral membrane protein
HFZ78_12160	COG2302	S4 RNA-binding domain
HFZ78_12165	COG3599	regulation of cell shape
HFZ78_12170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HFZ78_12185	COG0564	pseudouridine synthase activity
HFZ78_12190	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HFZ78_12200	COG0540	Belongs to the ATCase OTCase family
HFZ78_12215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HFZ78_12225	COG0167	dihydroorotate dehydrogenase activity
HFZ78_12230	COG0284	orotidine-5'-phosphate decarboxylase activity
HFZ78_12235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HFZ78_12245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFZ78_12250	COG1561	YicC-like family, N-terminal region
HFZ78_12260	COG0194	GDP metabolic process
HFZ78_12270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HFZ78_12275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HFZ78_12290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HFZ78_12290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HFZ78_12295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HFZ78_12300	COG0631	protein serine/threonine phosphatase activity
HFZ78_12305	COG0515	serine threonine protein kinase
HFZ78_12305	COG2815	serine threonine protein kinase
HFZ78_12310	COG1162	GTPase activity
HFZ78_12315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFZ78_12320	COG1564	THIamine pyrophosphokinase
HFZ78_12330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HFZ78_12335	COG1302	Protein conserved in bacteria
HFZ78_12340	COG1461	Dihydroxyacetone kinase
HFZ78_12345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HFZ78_12350	COG1349	DNA-binding transcription factor activity
HFZ78_12355	COG0416	fatty acid biosynthetic process
HFZ78_12360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HFZ78_12365	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_12380	COG1196	nuclear chromosome segregation
HFZ78_12385	COG0552	protein localization to endoplasmic reticulum
HFZ78_12390	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HFZ78_12395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFZ78_12405	COG1837	Belongs to the UPF0109 family
HFZ78_12415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HFZ78_12420	COG0336	Belongs to the RNA methyltransferase TrmD family
HFZ78_12440	COG1760	l-serine dehydratase
HFZ78_12445	COG1760	l-serine dehydratase
HFZ78_12460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HFZ78_12465	COG0758	DNA mediated transformation
HFZ78_12470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HFZ78_12475	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HFZ78_12480	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HFZ78_12485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HFZ78_12490	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HFZ78_12500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HFZ78_12505	COG0528	UMP kinase activity
HFZ78_12510	COG0233	cytoplasmic translational termination
HFZ78_12520	COG4589	Belongs to the CDS family
HFZ78_12525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HFZ78_12530	COG0750	zinc metalloprotease
HFZ78_12535	COG2176	DNA-directed DNA polymerase activity
HFZ78_12540	COG0779	Required for maturation of 30S ribosomal subunits
HFZ78_12545	COG0195	Participates in both transcription termination and antitermination
HFZ78_12550	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HFZ78_12555	COG1358	cellular component organization or biogenesis
HFZ78_12565	COG1550	Protein conserved in bacteria
HFZ78_12570	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HFZ78_12575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HFZ78_12580	COG0196	riboflavin kinase activity
HFZ78_12585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HFZ78_12590	COG1185	polyribonucleotide nucleotidyltransferase activity
HFZ78_12595	COG0726	polysaccharide deacetylase
HFZ78_12600	COG0612	Peptidase, M16
HFZ78_12605	COG1873	PFAM PRC-barrel domain
HFZ78_12610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFZ78_12615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HFZ78_12620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HFZ78_12625	COG0527	aspartate kinase activity
HFZ78_12630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFZ78_12635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HFZ78_12640	COG0740	serine-type endopeptidase activity
HFZ78_12650	COG1674	ftsk spoiiie
HFZ78_12650	COG4980	gas vesicle protein
HFZ78_12655	COG2188	Transcriptional regulator
HFZ78_12680	COG0612	Peptidase, M16
HFZ78_12685	COG0612	Peptidase, M16
HFZ78_12690	COG0300	oxidoreductase activity
HFZ78_12705	COG1426	Protein conserved in bacteria
HFZ78_12710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HFZ78_12715	COG1058	Belongs to the CinA family
HFZ78_12715	COG1546	Belongs to the CinA family
HFZ78_12720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HFZ78_12730	COG1692	metallophosphoesterase
HFZ78_12735	COG2359	stage V sporulation protein S
HFZ78_12740	COG0674	pyruvate-flavodoxin oxidoreductase activity
HFZ78_12740	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HFZ78_12745	COG1013	pyruvate-flavodoxin oxidoreductase activity
HFZ78_12750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HFZ78_12755	COG4550	Control of competence regulator ComK, YlbF/YmcA
HFZ78_12770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_12775	COG2112	serine threonine protein kinase
HFZ78_12790	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_12795	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_12805	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_12870	COG1053	succinate dehydrogenase
HFZ78_12875	COG1960	acyl-CoA dehydrogenase activity
HFZ78_12880	COG1960	acyl-CoA dehydrogenase activity
HFZ78_12885	COG0196	riboflavin kinase activity
HFZ78_12895	COG1053	succinate dehydrogenase
HFZ78_12900	COG0300	oxidoreductase activity
HFZ78_12925	COG2086	electron transfer activity
HFZ78_12930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFZ78_12935	COG1119	ATPase activity
HFZ78_12950	COG2972	Histidine kinase
HFZ78_12960	COG4213	ABC transporter substrate-binding protein
HFZ78_12970	COG4214	carbohydrate transport
HFZ78_12975	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_12975	COG3347	Dehydrogenase
HFZ78_12985	COG0697	spore germination
HFZ78_12990	COG1070	Carbohydrate kinase
HFZ78_12995	COG4806	L-rhamnose isomerase
HFZ78_13000	COG1349	DNA-binding transcription factor activity
HFZ78_13005	COG3507	Belongs to the glycosyl hydrolase 43 family
HFZ78_13015	COG0673	inositol 2-dehydrogenase activity
HFZ78_13020	COG2814	Major facilitator Superfamily
HFZ78_13030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HFZ78_13035	COG2972	Histidine kinase
HFZ78_13040	COG2207	Transcriptional regulator
HFZ78_13050	COG4209	transmembrane transport
HFZ78_13055	COG0395	ABC-type sugar transport system, permease component
HFZ78_13060	COG5578	integral membrane protein
HFZ78_13065	COG3408	Glycogen debranching enzyme
HFZ78_13085	COG2207	Transcriptional regulator
HFZ78_13085	COG1917	Cupin 2, conserved barrel domain protein
HFZ78_13090	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_13105	COG3959	Transketolase, thiamine diphosphate binding domain
HFZ78_13110	COG3958	Transketolase
HFZ78_13115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFZ78_13125	COG0583	DNA-binding transcription factor activity
HFZ78_13130	COG0567	Dehydrogenase, E1 component
HFZ78_13135	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ78_13150	COG0583	DNA-binding transcription factor activity
HFZ78_13155	COG0583	DNA-binding transcription factor activity
HFZ78_13170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HFZ78_13205	COG1335	isochorismatase
HFZ78_13225	COG0346	lactoylglutathione lyase activity
HFZ78_13235	COG0400	carboxylic ester hydrolase activity
HFZ78_13240	COG2267	carboxylic ester hydrolase activity
HFZ78_13255	COG4974	Belongs to the 'phage' integrase family
HFZ78_13270	COG5522	Integral membrane protein (intg_mem_TP0381)
HFZ78_13275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HFZ78_13280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HFZ78_13285	COG1077	Cell shape determining protein MreB Mrl
HFZ78_13290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HFZ78_13295	COG1923	regulation of RNA biosynthetic process
HFZ78_13300	COG0464	growth
HFZ78_13305	COG2860	membrane
HFZ78_13310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HFZ78_13320	COG0789	Transcriptional regulator
HFZ78_13325	COG0174	glutamine synthetase
HFZ78_13335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFZ78_13340	COG1388	LysM domain
HFZ78_13345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFZ78_13365	COG3763	UPF0154 protein
HFZ78_13370	COG1132	(ABC) transporter
HFZ78_13375	COG1132	(ABC) transporter
HFZ78_13385	COG0785	Cytochrome C biogenesis protein
HFZ78_13390	COG4846	Membrane protein involved in cytochrome C biogenesis
HFZ78_13405	COG4974	Belongs to the 'phage' integrase family
HFZ78_13465	COG1401	restriction endodeoxyribonuclease activity
HFZ78_13470	COG4268	DNA restriction-modification system
HFZ78_13510	COG0582	viral genome integration into host DNA
HFZ78_13555	COG0778	Nitroreductase
HFZ78_13575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFZ78_13580	COG4224	UPF0291 protein
HFZ78_13585	COG1959	2 iron, 2 sulfur cluster binding
HFZ78_13615	COG1278	Cold shock
HFZ78_13635	COG4974	Belongs to the 'phage' integrase family
HFZ78_13700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_13710	COG0697	spore germination
HFZ78_13740	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFZ78_13745	COG0110	maltose O-acetyltransferase activity
HFZ78_13760	COG2205	protein histidine kinase activity
HFZ78_13765	COG2364	Membrane
HFZ78_13770	COG2153	protein acetylation
HFZ78_13775	COG1846	Transcriptional regulator
HFZ78_13780	COG0456	acetyltransferase
HFZ78_13810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HFZ78_13825	COG1393	Belongs to the ArsC family
HFZ78_13830	COG1846	Transcriptional regulator
HFZ78_13835	COG2259	Doxx family
HFZ78_13840	COG0346	lactoylglutathione lyase activity
HFZ78_13845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_13850	COG0346	lactoylglutathione lyase activity
HFZ78_13855	COG0400	carboxylic ester hydrolase activity
HFZ78_13860	COG2259	Doxx family
HFZ78_13870	COG1741	Belongs to the pirin family
HFZ78_13885	COG0583	DNA-binding transcription factor activity
HFZ78_13890	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_13895	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_13900	COG1454	alcohol dehydrogenase
HFZ78_13905	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HFZ78_13910	COG2271	Major facilitator Superfamily
HFZ78_13925	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFZ78_13930	COG1024	Enoyl-CoA hydratase
HFZ78_13935	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HFZ78_13940	COG0457	Tetratricopeptide repeat
HFZ78_13945	COG1404	Belongs to the peptidase S8 family
HFZ78_13965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFZ78_13970	COG2323	membrane
HFZ78_13980	COG1309	transcriptional regulator
HFZ78_13985	COG2814	Major facilitator Superfamily
HFZ78_14005	COG2972	Histidine kinase
HFZ78_14010	COG3279	Response regulator of the LytR AlgR family
HFZ78_14015	COG1879	ABC-type sugar transport system periplasmic component
HFZ78_14025	COG3940	Belongs to the glycosyl hydrolase 43 family
HFZ78_14030	COG1879	ABC-type sugar transport system periplasmic component
HFZ78_14035	COG1129	ABC transporter
HFZ78_14040	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ78_14045	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFZ78_14050	COG5492	domain, Protein
HFZ78_14105	COG1876	peptidase activity
HFZ78_14120	COG1404	Belongs to the peptidase S8 family
HFZ78_14130	COG0697	spore germination
HFZ78_14135	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_14145	COG0583	DNA-binding transcription factor activity
HFZ78_14155	COG0583	DNA-binding transcription factor activity
HFZ78_14160	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_14170	COG2271	Major facilitator Superfamily
HFZ78_14205	COG2271	Major facilitator Superfamily
HFZ78_14215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_14220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_14230	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_14250	COG0583	DNA-binding transcription factor activity
HFZ78_14260	COG0583	DNA-binding transcription factor activity
HFZ78_14265	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_14275	COG0596	Alpha beta hydrolase
HFZ78_14290	COG2271	Major facilitator Superfamily
HFZ78_14305	COG0583	DNA-binding transcription factor activity
HFZ78_14310	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_14320	COG0300	oxidoreductase activity
HFZ78_14325	COG1960	acyl-CoA dehydrogenase activity
HFZ78_14330	COG2030	dehydratase
HFZ78_14340	COG2086	electron transfer activity
HFZ78_14345	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFZ78_14350	COG0439	Biotin carboxylase
HFZ78_14355	COG0511	ligase activity, forming carbon-carbon bonds
HFZ78_14360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFZ78_14370	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFZ78_14375	COG5002	protein histidine kinase activity
HFZ78_14390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_14390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_14395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_14395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_14400	COG0183	Belongs to the thiolase family
HFZ78_14440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ78_14455	COG1573	uracil-dna glycosylase
HFZ78_14480	COG3835	regulator
HFZ78_14485	COG1960	acyl-CoA dehydrogenase activity
HFZ78_14490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ78_14495	COG0439	Biotin carboxylase
HFZ78_14500	COG0511	ligase activity, forming carbon-carbon bonds
HFZ78_14505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFZ78_14510	COG1024	Enoyl-CoA hydratase
HFZ78_14515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFZ78_14520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_14525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_14530	COG2094	Belongs to the DNA glycosylase MPG family
HFZ78_14545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFZ78_14550	COG1609	Transcriptional regulator
HFZ78_14590	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFZ78_14610	COG1175	transmembrane transport
HFZ78_14625	COG2972	Histidine kinase
HFZ78_14630	COG2207	Transcriptional regulator
HFZ78_14630	COG4753	response regulator
HFZ78_14640	COG1113	amino acid transport
HFZ78_14645	COG2814	Major facilitator Superfamily
HFZ78_14655	COG2188	Transcriptional regulator
HFZ78_14660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFZ78_14665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HFZ78_14670	COG1486	melibiose metabolic process
HFZ78_14675	COG1447	Phosphotransferase system cellobiose-specific component IIA
HFZ78_14705	COG1396	sequence-specific DNA binding
HFZ78_14710	COG0252	asparaginase activity
HFZ78_14720	COG2755	lipolytic protein G-D-S-L family
HFZ78_14725	COG3290	protein histidine kinase activity
HFZ78_14730	COG4565	transcriptional regulatory protein
HFZ78_14735	COG2851	Citrate transporter
HFZ78_14760	COG2814	Major facilitator Superfamily
HFZ78_14765	COG2368	4-hydroxyphenylacetate
HFZ78_14770	COG0196	riboflavin kinase activity
HFZ78_14775	COG0431	NADPH-dependent FMN reductase
HFZ78_14800	COG3971	2-oxopent-4-enoate hydratase activity
HFZ78_14810	COG3844	kynureninase activity
HFZ78_14815	COG1113	amino acid transport
HFZ78_14820	COG3483	tryptophan 2,3-dioxygenase activity
HFZ78_14825	COG1376	ErfK ybiS ycfS ynhG family protein
HFZ78_14835	COG1114	Component of the transport system for branched-chain amino acids
HFZ78_14850	COG1533	DNA photolyase activity
HFZ78_14855	COG0477	Major facilitator Superfamily
HFZ78_14860	COG1309	transcriptional regulator
HFZ78_14865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFZ78_14870	COG1368	sulfuric ester hydrolase activity
HFZ78_14880	COG0697	spore germination
HFZ78_14905	COG0175	sulfate reduction
HFZ78_14910	COG0306	phosphate transporter
HFZ78_14920	COG0529	Catalyzes the synthesis of activated sulfate
HFZ78_14930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_14935	COG2814	Major facilitator Superfamily
HFZ78_14940	COG1846	Transcriptional regulator
HFZ78_14945	COG1027	Aspartate ammonia-lyase
HFZ78_14955	COG2720	vancomycin resistance protein
HFZ78_14965	COG3829	transcription factor binding
HFZ78_14970	COG0833	amino acid
HFZ78_14980	COG1695	Transcriptional regulator
HFZ78_15010	COG0659	secondary active sulfate transmembrane transporter activity
HFZ78_15030	COG0419	ATPase involved in DNA repair
HFZ78_15060	COG2310	stress, protein
HFZ78_15065	COG1033	growth of symbiont in host cell
HFZ78_15065	COG2409	Drug exporters of the RND superfamily
HFZ78_15070	COG1846	Transcriptional regulator
HFZ78_15080	COG0745	RESPONSE REGULATOR receiver
HFZ78_15085	COG5002	protein histidine kinase activity
HFZ78_15095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HFZ78_15110	COG2304	oxidoreductase activity
HFZ78_15135	COG1131	(ABC) transporter
HFZ78_15140	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HFZ78_15155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFZ78_15160	COG1363	Peptidase, m42
HFZ78_15170	COG0598	Magnesium transport protein CorA
HFZ78_15180	COG1388	LysM domain
HFZ78_15180	COG0791	NLP P60 protein
HFZ78_15185	COG0398	Pfam SNARE associated Golgi protein
HFZ78_15200	COG1272	protein, Hemolysin III
HFZ78_15205	COG0477	Major facilitator Superfamily
HFZ78_15210	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HFZ78_15220	COG2080	2 iron, 2 sulfur cluster binding
HFZ78_15230	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HFZ78_15235	COG0861	Integral membrane protein TerC family
HFZ78_15240	COG0671	phosphoesterase, PA-phosphatase related
HFZ78_15245	COG1183	phosphatidylcholine synthase activity
HFZ78_15250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HFZ78_15255	COG1845	cytochrome c oxidase, subunit III
HFZ78_15260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFZ78_15275	COG0071	Belongs to the small heat shock protein (HSP20) family
HFZ78_15290	COG0561	phosphatase activity
HFZ78_15295	COG1278	Cold shock
HFZ78_15300	COG4895	conserved protein (DUF2196)
HFZ78_15310	COG0753	catalase activity
HFZ78_15320	COG0307	riboflavin synthase, alpha
HFZ78_15325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFZ78_15325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFZ78_15330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HFZ78_15335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFZ78_15340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_15345	COG1120	ATPase activity
HFZ78_15350	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HFZ78_15355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HFZ78_15360	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HFZ78_15365	COG1492	cobalamin metabolic process
HFZ78_15370	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HFZ78_15385	COG2096	Adenosyltransferase
HFZ78_15400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ78_15405	COG1136	(ABC) transporter
HFZ78_15410	COG0577	efflux transmembrane transporter activity
HFZ78_15420	COG2211	Major facilitator Superfamily
HFZ78_15435	COG0697	spore germination
HFZ78_15445	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_15450	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_15455	COG5002	protein histidine kinase activity
HFZ78_15460	COG1247	-acetyltransferase
HFZ78_15480	COG1960	acyl-CoA dehydrogenase activity
HFZ78_15505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HFZ78_15510	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_15515	COG0183	Belongs to the thiolase family
HFZ78_15520	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_15550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_15555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFZ78_15560	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_15565	COG1454	alcohol dehydrogenase
HFZ78_15575	COG1227	inorganic diphosphatase activity
HFZ78_15580	COG2233	PERMEase
HFZ78_15590	COG0561	phosphatase activity
HFZ78_15605	COG0519	Catalyzes the synthesis of GMP from XMP
HFZ78_15625	COG2357	RelA SpoT domain protein
HFZ78_15630	COG0516	GMP reductase activity
HFZ78_15630	COG0517	IMP dehydrogenase activity
HFZ78_15640	COG1408	metallophosphoesterase
HFZ78_15660	COG2270	Major facilitator Superfamily
HFZ78_15690	COG3290	protein histidine kinase activity
HFZ78_15695	COG4565	transcriptional regulatory protein
HFZ78_15715	COG0322	excinuclease ABC activity
HFZ78_15720	COG2310	stress, protein
HFZ78_15740	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HFZ78_15745	COG1228	amidohydrolase
HFZ78_15750	COG0010	Belongs to the arginase family
HFZ78_15760	COG0671	phosphoesterase, PA-phosphatase related
HFZ78_15770	COG4191	Histidine kinase
HFZ78_15775	COG2204	response regulator
HFZ78_15850	COG1301	dicarboxylic acid transport
HFZ78_15860	COG3290	protein histidine kinase activity
HFZ78_15870	COG0351	phosphomethylpyrimidine kinase
HFZ78_15885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ78_15890	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HFZ78_15895	COG1116	anion transmembrane transporter activity
HFZ78_15900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ78_15905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ78_15930	COG1278	Cold shock
HFZ78_15940	COG0659	secondary active sulfate transmembrane transporter activity
HFZ78_15950	COG0640	Transcriptional regulator
HFZ78_15955	COG0534	Mate efflux family protein
HFZ78_15975	COG1609	Transcriptional regulator
HFZ78_15980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_15980	COG1263	PTS System
HFZ78_15985	COG1621	beta-fructofuranosidase activity
HFZ78_16000	COG0454	-acetyltransferase
HFZ78_16005	COG4319	ketosteroid isomerase
HFZ78_16010	COG2329	Antibiotic biosynthesis monooxygenase
HFZ78_16035	COG1349	DNA-binding transcription factor activity
HFZ78_16040	COG4549	nuclear export factor GLE1
HFZ78_16050	COG3180	Ammonia monooxygenase
HFZ78_16075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HFZ78_16085	COG3883	PFAM NLP P60 protein
HFZ78_16085	COG0791	NLP P60 protein
HFZ78_16100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFZ78_16125	COG0326	Molecular chaperone. Has ATPase activity
HFZ78_16130	COG0346	lactoylglutathione lyase activity
HFZ78_16135	COG0667	Aldo Keto reductase
HFZ78_16145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ78_16150	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HFZ78_16155	COG1687	branched-chain amino acid
HFZ78_16170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFZ78_16175	COG0431	NADPH-dependent FMN reductase
HFZ78_16180	COG0196	riboflavin kinase activity
HFZ78_16190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ78_16220	COG0531	amino acid
HFZ78_16225	COG0583	DNA-binding transcription factor activity
HFZ78_16230	COG0697	spore germination
HFZ78_16235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFZ78_16240	COG1522	sequence-specific DNA binding
HFZ78_16280	COG1609	Transcriptional regulator
HFZ78_16290	COG0720	synthase
HFZ78_16295	COG0602	queuosine metabolic process
HFZ78_16305	COG0352	thiamine-phosphate diphosphorylase activity
HFZ78_16310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ78_16315	COG2104	thiamine diphosphate biosynthetic process
HFZ78_16320	COG2022	thiamine diphosphate biosynthetic process
HFZ78_16325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HFZ78_16340	COG0586	Pfam SNARE associated Golgi protein
HFZ78_16365	COG0730	response to heat
HFZ78_16395	COG3655	Transcriptional regulator
HFZ78_16400	COG1309	transcriptional regulator
HFZ78_16410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFZ78_16420	COG0702	epimerase
HFZ78_16430	COG3848	Pyruvate phosphate dikinase
HFZ78_16430	COG0574	Belongs to the PEP-utilizing enzyme family
HFZ78_16440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFZ78_16485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_16495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ78_16530	COG2207	Transcriptional regulator
HFZ78_16545	COG4978	Transcriptional regulator
HFZ78_16545	COG0789	Transcriptional regulator
HFZ78_16550	COG1811	Na channel or pump
HFZ78_16555	COG1335	isochorismatase
HFZ78_16560	COG0702	epimerase
HFZ78_16585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFZ78_16590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_16595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_16600	COG3338	carbonate dehydratase activity
HFZ78_16610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFZ78_16620	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HFZ78_16625	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HFZ78_16625	COG3608	succinylglutamate desuccinylase aspartoacylase
HFZ78_16630	COG0789	Transcriptional regulator
HFZ78_16635	COG1064	alcohol dehydrogenase
HFZ78_16640	COG0583	DNA-binding transcription factor activity
HFZ78_16645	COG4221	oxidoreductase activity
HFZ78_16670	COG2814	Major facilitator Superfamily
HFZ78_16675	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_16680	COG1064	alcohol dehydrogenase
HFZ78_16690	COG0110	maltose O-acetyltransferase activity
HFZ78_16700	COG1309	transcriptional regulator
HFZ78_16705	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFZ78_16710	COG2814	Major facilitator Superfamily
HFZ78_16730	COG0165	Argininosuccinate lyase
HFZ78_16740	COG1960	acyl-CoA dehydrogenase activity
HFZ78_16750	COG2267	carboxylic ester hydrolase activity
HFZ78_16800	COG2801	Transposase and inactivated derivatives
HFZ78_16825	COG0673	inositol 2-dehydrogenase activity
HFZ78_16830	COG0110	maltose O-acetyltransferase activity
HFZ78_16845	COG2169	Transcriptional regulator
HFZ78_16870	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_16885	COG4585	Histidine kinase
HFZ78_16890	COG2197	response regulator
HFZ78_16895	COG2211	Major facilitator Superfamily
HFZ78_16900	COG2207	Transcriptional regulator
HFZ78_16905	COG2723	6-phospho-beta-galactosidase activity
HFZ78_16910	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_16915	COG3250	beta-galactosidase activity
HFZ78_16920	COG4977	sequence-specific DNA binding
HFZ78_16925	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_16960	COG2197	response regulator
HFZ78_16980	COG0697	spore germination
HFZ78_16985	COG0814	amino acid
HFZ78_17010	COG1309	transcriptional regulator
HFZ78_17025	COG0789	Transcriptional regulator
HFZ78_17025	COG4978	Transcriptional regulator
HFZ78_17030	COG2814	Major facilitator Superfamily
HFZ78_17035	COG2323	membrane
HFZ78_17050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFZ78_17075	COG1335	isochorismatase
HFZ78_17125	COG1846	Transcriptional regulator
HFZ78_17145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFZ78_17170	COG5002	protein histidine kinase activity
HFZ78_17200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HFZ78_17220	COG0583	DNA-binding transcription factor activity
HFZ78_17230	COG0697	spore germination
HFZ78_17265	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HFZ78_17270	COG3052	prosthetic group binding
HFZ78_17285	COG2364	Membrane
HFZ78_17290	COG1846	Transcriptional regulator
HFZ78_17295	COG0456	acetyltransferase
HFZ78_17300	COG2808	Putative FMN-binding domain
HFZ78_17365	COG1113	amino acid transport
HFZ78_17405	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_17420	COG1846	Transcriptional regulator
HFZ78_17425	COG2259	Doxx family
HFZ78_17430	COG0346	lactoylglutathione lyase activity
HFZ78_17435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_17445	COG0400	carboxylic ester hydrolase activity
HFZ78_17450	COG2259	Doxx family
HFZ78_17455	COG0655	NAD(P)H dehydrogenase (quinone) activity
HFZ78_17525	COG2323	membrane
HFZ78_17550	COG0412	Dienelactone hydrolase
HFZ78_17565	COG1247	-acetyltransferase
HFZ78_17575	COG0222	ribosome binding
HFZ78_17585	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_17605	COG2076	Multidrug Resistance protein
HFZ78_17610	COG2076	Multidrug Resistance protein
HFZ78_17615	COG3942	CHAP domain
HFZ78_17615	COG1388	LysM domain
HFZ78_17645	COG0589	response to stress
HFZ78_17655	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_17665	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_17665	COG0604	alcohol dehydrogenase
HFZ78_17665	COG3321	synthase
HFZ78_17670	COG0747	negative chemotaxis
HFZ78_17675	COG0601	transmembrane transport
HFZ78_17680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFZ78_17685	COG0444	Belongs to the ABC transporter superfamily
HFZ78_17690	COG4608	Belongs to the ABC transporter superfamily
HFZ78_17695	COG0534	Mate efflux family protein
HFZ78_17765	COG1492	cobalamin metabolic process
HFZ78_17770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HFZ78_17775	COG1587	Uroporphyrinogen-III synthase
HFZ78_17775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFZ78_17785	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HFZ78_17800	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HFZ78_17805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HFZ78_17810	COG1473	amidohydrolase
HFZ78_17820	COG0701	Predicted permease
HFZ78_17865	COG1937	Protein conserved in bacteria
HFZ78_17870	COG2608	mercury ion transmembrane transporter activity
HFZ78_17880	COG2217	Heavy metal translocating P-type atpase
HFZ78_17895	COG0789	Transcriptional regulator
HFZ78_17895	COG4978	Transcriptional regulator
HFZ78_17900	COG0531	amino acid
HFZ78_17905	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_17925	COG2271	Major facilitator Superfamily
HFZ78_17945	COG0460	homoserine dehydrogenase
HFZ78_17950	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_17955	COG0833	amino acid
HFZ78_17960	COG1823	symporter activity
HFZ78_17985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFZ78_18015	COG3443	Belongs to the bacterial solute-binding protein 9 family
HFZ78_18055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFZ78_18060	COG0523	cobalamin synthesis protein
HFZ78_18070	COG0701	Predicted permease
HFZ78_18075	COG0803	Belongs to the bacterial solute-binding protein 9 family
HFZ78_18120	COG1175	transmembrane transport
HFZ78_18135	COG4753	response regulator
HFZ78_18135	COG2207	Transcriptional regulator
HFZ78_18160	COG0019	diaminopimelate decarboxylase activity
HFZ78_18180	COG0640	Transcriptional regulator
HFZ78_18190	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HFZ78_18195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ78_18200	COG0156	8-amino-7-oxononanoate synthase activity
HFZ78_18215	COG1988	membrane-bound metal-dependent
HFZ78_18245	COG0202	RNA polymerase activity
HFZ78_18280	COG2801	Transposase and inactivated derivatives
HFZ78_18305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HFZ78_18330	COG0523	cobalamin synthesis protein
HFZ78_18335	COG0523	cobalamin synthesis protein
HFZ78_18340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFZ78_18350	COG1469	GTP cyclohydrolase I activity
HFZ78_18380	COG4303	Ethanolamine ammonia lyase large subunit
HFZ78_18385	COG4302	ethanolamine ammonia-lyase activity
HFZ78_18395	COG1454	alcohol dehydrogenase
HFZ78_18395	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_18410	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HFZ78_18415	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HFZ78_18420	COG0039	L-malate dehydrogenase activity
HFZ78_18425	COG0531	amino acid
HFZ78_18430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ78_18440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ78_18450	COG0084	hydrolase, TatD family'
HFZ78_18520	COG1525	nuclease
HFZ78_18530	COG1393	Belongs to the ArsC family
HFZ78_18570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFZ78_18570	COG2169	Transcriptional regulator
HFZ78_18615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HFZ78_18625	COG0305	Participates in initiation and elongation during chromosome replication
HFZ78_18650	COG4974	Belongs to the 'phage' integrase family
HFZ78_18775	COG1401	restriction endodeoxyribonuclease activity
HFZ78_18790	COG1074	ATP-dependent DNA helicase activity
HFZ78_18805	COG0210	DNA helicase
HFZ78_18820	COG0514	ATP-dependent DNA helicase (RecQ)
HFZ78_18825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HFZ78_18865	COG1309	transcriptional regulator
HFZ78_18870	COG3118	belongs to the thioredoxin family
HFZ78_18910	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_18915	COG1404	Belongs to the peptidase S8 family
HFZ78_18915	COG4412	M6 family metalloprotease domain protein
HFZ78_18920	COG0583	DNA-binding transcription factor activity
HFZ78_18935	COG2188	Transcriptional regulator
HFZ78_18940	COG1840	ABC-type Fe3 transport system, periplasmic component
HFZ78_18950	COG1176	ABC-type spermidine putrescine transport system, permease component I
HFZ78_18955	COG1177	transmembrane transport
HFZ78_18975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ78_18985	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_18995	COG0067	glutamate synthase
HFZ78_18995	COG0070	glutamate synthase
HFZ78_18995	COG0069	glutamate synthase activity
HFZ78_19000	COG0493	'glutamate synthase
HFZ78_19005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFZ78_19010	COG2146	nitrite reductase [NAD(P)H] activity
HFZ78_19015	COG2116	formate transmembrane transporter activity
HFZ78_19025	COG2814	Major facilitator Superfamily
HFZ78_19055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFZ78_19065	COG0697	spore germination
HFZ78_19080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_19090	COG2801	Transposase and inactivated derivatives
HFZ78_19095	COG0506	proline dehydrogenase activity
HFZ78_19100	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_19105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_19135	COG1733	regulation of RNA biosynthetic process
HFZ78_19140	COG0778	Nitroreductase
HFZ78_19170	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_19180	COG4221	oxidoreductase activity
HFZ78_19185	COG2207	Transcriptional regulator
HFZ78_19215	COG2085	NADP oxidoreductase coenzyme F420-dependent
HFZ78_19220	COG1733	regulation of RNA biosynthetic process
HFZ78_19225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFZ78_19270	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HFZ78_19385	COG0640	Transcriptional regulator
HFZ78_19400	COG0242	peptide deformylase activity
HFZ78_19415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HFZ78_19425	COG0583	DNA-binding transcription factor activity
HFZ78_19430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFZ78_19430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFZ78_19440	COG1301	dicarboxylic acid transport
HFZ78_19470	COG2318	DinB family
HFZ78_19475	COG2318	DinB family
HFZ78_19510	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_19515	COG2814	Major facilitator Superfamily
HFZ78_19555	COG1105	Belongs to the carbohydrate kinase PfkB family
HFZ78_19560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_19560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_19560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_19565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_19570	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_19575	COG0069	glutamate synthase activity
HFZ78_19580	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ78_19590	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_19640	COG1942	4-Oxalocrotonate Tautomerase
HFZ78_19695	COG0583	DNA-binding transcription factor activity
HFZ78_19705	COG0456	acetyltransferase
HFZ78_19715	COG2315	Protein conserved in bacteria
HFZ78_19735	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HFZ78_19740	COG5002	protein histidine kinase activity
HFZ78_19750	COG0583	DNA-binding transcription factor activity
HFZ78_19755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_19775	COG0789	Transcriptional regulator
HFZ78_19780	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_19785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFZ78_19800	COG0697	spore germination
HFZ78_19805	COG3275	phosphorelay sensor kinase activity
HFZ78_19810	COG3279	Response regulator of the LytR AlgR family
HFZ78_19815	COG2223	nitrite transmembrane transporter activity
HFZ78_19825	COG0697	spore germination
HFZ78_19865	COG5001	Diguanylate cyclase
HFZ78_19880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HFZ78_19900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HFZ78_19930	COG0531	amino acid
HFZ78_19935	COG0697	spore germination
HFZ78_19995	COG2318	DinB family
HFZ78_20010	COG4974	Belongs to the 'phage' integrase family
HFZ78_20015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_20020	COG0583	DNA-binding transcription factor activity
HFZ78_20030	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFZ78_20045	COG4974	Belongs to the 'phage' integrase family
HFZ78_20060	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_20065	COG0789	Transcriptional regulator
HFZ78_20130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFZ78_20140	COG3655	Transcriptional regulator
HFZ78_20150	COG0517	IMP dehydrogenase activity
HFZ78_20160	COG3773	Cell wall hydrolase
HFZ78_20165	COG0493	'glutamate synthase
HFZ78_20170	COG0167	dihydroorotate dehydrogenase activity
HFZ78_20195	COG3835	regulator
HFZ78_20200	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_20205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ78_20230	COG0400	carboxylic ester hydrolase activity
HFZ78_20235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HFZ78_20240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HFZ78_20255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HFZ78_20260	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HFZ78_20305	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ78_20305	COG0596	Alpha beta hydrolase
HFZ78_20315	COG2259	Doxx family
HFZ78_20320	COG3384	dioxygenase
HFZ78_20335	COG3858	chitin binding
HFZ78_20345	COG1164	Oligoendopeptidase f
HFZ78_20355	COG1215	transferase activity, transferring glycosyl groups
HFZ78_20355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HFZ78_20375	COG0714	Associated with various cellular activities
HFZ78_20390	COG1714	RDD family
HFZ78_20410	COG0477	Major facilitator Superfamily
HFZ78_20420	COG1309	transcriptional regulator
HFZ78_20430	COG2814	Major facilitator Superfamily
HFZ78_20440	COG2207	Transcriptional regulator
HFZ78_20450	COG0656	L-ascorbic acid biosynthetic process
HFZ78_20465	COG1309	transcriptional regulator
HFZ78_20470	COG0534	Mate efflux family protein
HFZ78_20525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HFZ78_20530	COG0187	DNA topoisomerase II activity
HFZ78_20535	COG1832	CoA-binding protein
HFZ78_20550	COG2207	Transcriptional regulator
HFZ78_20550	COG4753	response regulator
HFZ78_20555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HFZ78_20575	COG0824	Thioesterase
HFZ78_20580	COG0464	growth
HFZ78_20600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_20605	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HFZ78_20620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HFZ78_20660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_20680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HFZ78_20685	COG2233	PERMEase
HFZ78_20695	COG2233	PERMEase
HFZ78_20700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_20715	COG0488	(ABC) transporter
HFZ78_20725	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HFZ78_20730	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HFZ78_20735	COG3639	organic phosphonate transmembrane transporter activity
HFZ78_20750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_20765	COG0701	Predicted permease
HFZ78_20770	COG3689	TIGRFAM TIGR03943 family protein
HFZ78_20775	COG0803	Belongs to the bacterial solute-binding protein 9 family
HFZ78_20780	COG0701	Predicted permease
HFZ78_20795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HFZ78_20805	COG0438	transferase activity, transferring glycosyl groups
HFZ78_20810	COG1215	transferase activity, transferring glycosyl groups
HFZ78_20815	COG3206	protein involved in exopolysaccharide biosynthesis
HFZ78_20820	COG3307	-O-antigen
HFZ78_20825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_20830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HFZ78_20835	COG0297	glycogen (starch) synthase activity
HFZ78_20835	COG0438	transferase activity, transferring glycosyl groups
HFZ78_20840	COG2244	polysaccharide biosynthetic process
HFZ78_20850	COG1253	flavin adenine dinucleotide binding
HFZ78_20855	COG0789	Transcriptional regulator
HFZ78_20860	COG0024	Methionine aminopeptidase
HFZ78_20880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HFZ78_20890	COG5337	Spore coat protein CotH
HFZ78_20915	COG3011	Protein conserved in bacteria
HFZ78_20935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_20935	COG1263	PTS System
HFZ78_20940	COG0366	Alpha amylase catalytic
HFZ78_20945	COG2188	Transcriptional regulator
HFZ78_20950	COG2135	peptidase activity
HFZ78_20955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFZ78_20965	COG0456	acetyltransferase
HFZ78_21005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFZ78_21015	COG0697	spore germination
HFZ78_21025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HFZ78_21030	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HFZ78_21040	COG1114	Component of the transport system for branched-chain amino acids
HFZ78_21045	COG0765	amino acid transport
HFZ78_21050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_21055	COG1126	abc transporter atp-binding protein
HFZ78_21060	COG3829	transcription factor binding
HFZ78_21070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_21075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFZ78_21080	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_21090	COG0477	Major facilitator Superfamily
HFZ78_21095	COG5002	protein histidine kinase activity
HFZ78_21105	COG2146	nitrite reductase [NAD(P)H] activity
HFZ78_21110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFZ78_21115	COG0243	molybdopterin cofactor binding
HFZ78_21120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFZ78_21125	COG2223	nitrite transmembrane transporter activity
HFZ78_21140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_21145	COG0529	Catalyzes the synthesis of activated sulfate
HFZ78_21150	COG2046	Belongs to the sulfate adenylyltransferase family
HFZ78_21155	COG0175	sulfate reduction
HFZ78_21165	COG1809	phosphosulfolactate synthase activity
HFZ78_21170	COG2814	Major facilitator Superfamily
HFZ78_21180	COG0730	response to heat
HFZ78_21185	COG0697	spore germination
HFZ78_21210	COG1357	PFAM Pentapeptide repeats (8 copies)
HFZ78_21220	COG0861	Integral membrane protein TerC family
HFZ78_21245	COG1522	sequence-specific DNA binding
HFZ78_21245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_21255	COG1247	-acetyltransferase
HFZ78_21265	COG2329	Antibiotic biosynthesis monooxygenase
HFZ78_21280	COG0183	Belongs to the thiolase family
HFZ78_21285	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_21295	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_21300	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFZ78_21315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFZ78_21320	COG1231	oxidoreductase activity
HFZ78_21335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ78_21345	COG1216	Glycosyl transferase, family 2
HFZ78_21355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFZ78_21360	COG1279	arginine transmembrane transporter activity
HFZ78_21365	COG0604	alcohol dehydrogenase
HFZ78_21375	COG0477	Major facilitator Superfamily
HFZ78_21395	COG0697	spore germination
HFZ78_21400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_21405	COG4932	domain protein
HFZ78_21405	COG1388	LysM domain
HFZ78_21410	COG4191	Histidine kinase
HFZ78_21430	COG0671	phosphoesterase, PA-phosphatase related
HFZ78_21445	COG0561	phosphatase activity
HFZ78_21465	COG0668	transmembrane transport
HFZ78_21490	COG1378	Sugar-specific transcriptional regulator TrmB
HFZ78_21495	COG1280	lysine exporter protein (LysE YggA)
HFZ78_21510	COG1733	regulation of RNA biosynthetic process
HFZ78_21520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFZ78_21540	COG1280	lysine exporter protein (LysE YggA)
HFZ78_21560	COG1587	Uroporphyrinogen-III synthase
HFZ78_21585	COG2814	Major facilitator Superfamily
HFZ78_21600	COG1346	cytolysis
HFZ78_21605	COG1380	Effector of murein hydrolase LrgA
HFZ78_21615	COG0716	FMN binding
HFZ78_21620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFZ78_21625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFZ78_21630	COG0737	Belongs to the 5'-nucleotidase family
HFZ78_21630	COG4085	toxin activity
HFZ78_21630	COG1525	nuclease
HFZ78_21635	COG2720	vancomycin resistance protein
HFZ78_21640	COG2116	formate transmembrane transporter activity
HFZ78_21645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFZ78_21650	COG2385	sporulation resulting in formation of a cellular spore
HFZ78_21660	COG0506	proline dehydrogenase activity
HFZ78_21665	COG2186	Transcriptional regulator
HFZ78_21670	COG1929	Belongs to the glycerate kinase type-1 family
HFZ78_21680	COG2084	Dehydrogenase
HFZ78_21685	COG2610	gluconate transmembrane transporter activity
HFZ78_21690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFZ78_21695	COG3835	regulator
HFZ78_21705	COG1098	S1 RNA binding domain
HFZ78_21710	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFZ78_21715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFZ78_21720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFZ78_21725	COG2318	DinB family
HFZ78_21735	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_21735	COG1454	alcohol dehydrogenase
HFZ78_21755	COG0765	amino acid transport
HFZ78_21760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_21765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HFZ78_21775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFZ78_21860	COG1802	Transcriptional regulator
HFZ78_21865	COG2059	Chromate
HFZ78_21870	COG2059	Chromate
HFZ78_21915	COG3069	C4-dicarboxylate transmembrane transporter activity
HFZ78_21920	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HFZ78_21940	COG0306	phosphate transporter
HFZ78_21945	COG2072	flavoprotein involved in K transport
HFZ78_21955	COG2197	response regulator
HFZ78_21960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ78_21970	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_21985	COG0028	Belongs to the TPP enzyme family
HFZ78_21995	COG0473	3-isopropylmalate dehydrogenase activity
HFZ78_22000	COG1289	transmembrane transporter activity
HFZ78_22005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HFZ78_22045	COG2226	methyltransferase
HFZ78_22055	COG1116	anion transmembrane transporter activity
HFZ78_22060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ78_22065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ78_22095	COG0788	formyltetrahydrofolate deformylase activity
HFZ78_22110	COG0534	Mate efflux family protein
HFZ78_22115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ78_22120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HFZ78_22125	COG2070	2-Nitropropane dioxygenase
HFZ78_22165	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_22170	COG3118	belongs to the thioredoxin family
HFZ78_22190	COG0493	'glutamate synthase
HFZ78_22195	COG0069	glutamate synthase activity
HFZ78_22195	COG0067	glutamate synthase
HFZ78_22195	COG0070	glutamate synthase
HFZ78_22200	COG0583	DNA-binding transcription factor activity
HFZ78_22205	COG0151	Belongs to the GarS family
HFZ78_22210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFZ78_22215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HFZ78_22220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFZ78_22225	COG0047	phosphoribosylformylglycinamidine synthase activity
HFZ78_22230	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFZ78_22235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HFZ78_22240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFZ78_22245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HFZ78_22260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HFZ78_22280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFZ78_22285	COG1414	Transcriptional regulator
HFZ78_22290	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_22305	COG0788	formyltetrahydrofolate deformylase activity
HFZ78_22310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFZ78_22320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFZ78_22325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFZ78_22330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFZ78_22335	COG0509	glycine decarboxylation via glycine cleavage system
HFZ78_22345	COG1760	l-serine dehydratase
HFZ78_22350	COG1760	l-serine dehydratase
HFZ78_22355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HFZ78_22360	COG1113	amino acid transport
HFZ78_22375	COG2207	Transcriptional regulator
HFZ78_22375	COG4753	response regulator
HFZ78_22380	COG2972	Histidine kinase
HFZ78_22385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HFZ78_22405	COG0531	amino acid
HFZ78_22410	COG0697	spore germination
HFZ78_22435	COG1733	regulation of RNA biosynthetic process
HFZ78_22445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFZ78_22455	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_22465	COG0402	S-adenosylhomocysteine deaminase activity
HFZ78_22475	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFZ78_22540	COG1126	abc transporter atp-binding protein
HFZ78_22545	COG0765	amino acid transport
HFZ78_22550	COG0765	amino acid transport
HFZ78_22555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_22570	COG2828	Protein conserved in bacteria
HFZ78_22575	COG0583	DNA-binding transcription factor activity
HFZ78_22590	COG3180	Ammonia monooxygenase
HFZ78_22595	COG0583	DNA-binding transcription factor activity
HFZ78_22600	COG1053	succinate dehydrogenase
HFZ78_22610	COG3103	Sh3 type 3 domain protein
HFZ78_22610	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFZ78_22610	COG4991	sh3 domain protein
HFZ78_22615	COG0523	cobalamin synthesis protein
HFZ78_22625	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFZ78_22630	COG0717	Belongs to the dCTP deaminase family
HFZ78_22635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFZ78_22650	COG3411	Ferredoxin
HFZ78_22655	COG0523	cobalamin synthesis protein
HFZ78_22660	COG0822	iron-sulfur transferase activity
HFZ78_22670	COG0701	Predicted permease
HFZ78_22675	COG1121	(ABC) transporter
HFZ78_22680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFZ78_22685	COG0803	Belongs to the bacterial solute-binding protein 9 family
HFZ78_22690	COG0735	belongs to the Fur family
HFZ78_22725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFZ78_22745	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_22750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_22755	COG0604	alcohol dehydrogenase
HFZ78_22760	COG2814	Major facilitator Superfamily
HFZ78_22765	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_22780	COG1472	Belongs to the glycosyl hydrolase 3 family
HFZ78_22790	COG1846	Transcriptional regulator
HFZ78_22795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_22820	COG1404	Belongs to the peptidase S8 family
HFZ78_22825	COG0583	DNA-binding transcription factor activity
HFZ78_22830	COG1876	peptidase activity
HFZ78_22845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFZ78_22890	COG1764	response to oxidative stress
HFZ78_22895	COG0655	NAD(P)H dehydrogenase (quinone) activity
HFZ78_22900	COG0400	carboxylic ester hydrolase activity
HFZ78_22910	COG0346	lactoylglutathione lyase activity
HFZ78_22915	COG1846	Transcriptional regulator
HFZ78_22920	COG1393	Belongs to the ArsC family
HFZ78_22930	COG1388	LysM domain
HFZ78_22930	COG3858	chitin binding
HFZ78_22940	COG0655	NAD(P)H dehydrogenase (quinone) activity
HFZ78_22950	COG0346	lactoylglutathione lyase activity
HFZ78_22960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFZ78_22970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HFZ78_22985	COG1914	H( )-stimulated, divalent metal cation uptake system
HFZ78_22995	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HFZ78_23015	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HFZ78_23025	COG5002	protein histidine kinase activity
HFZ78_23045	COG1181	Belongs to the D-alanine--D-alanine ligase family
HFZ78_23065	COG0778	Nitroreductase
HFZ78_23070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ78_23075	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HFZ78_23080	COG1263	PTS System
HFZ78_23080	COG2190	(PTS) system
HFZ78_23080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HFZ78_23095	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFZ78_23100	COG0281	malic enzyme
HFZ78_23120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HFZ78_23125	COG3383	formate dehydrogenase (NAD+) activity
HFZ78_23130	COG5609	conserved protein (DUF2294)
HFZ78_23140	COG1619	proteins homologs of microcin C7 resistance protein MccF
HFZ78_23145	COG1525	nuclease
HFZ78_23160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HFZ78_23165	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HFZ78_23175	COG0393	Putative heavy-metal-binding
HFZ78_23180	COG1960	acyl-CoA dehydrogenase activity
HFZ78_23185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFZ78_23195	COG3973	AAA domain
HFZ78_23210	COG1959	2 iron, 2 sulfur cluster binding
HFZ78_23225	COG5002	protein histidine kinase activity
HFZ78_23230	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HFZ78_23235	COG0784	Response regulator, receiver
HFZ78_23235	COG2205	protein histidine kinase activity
HFZ78_23240	COG0028	Belongs to the TPP enzyme family
HFZ78_23245	COG4948	Mandelate Racemase Muconate Lactonizing
HFZ78_23260	COG0765	amino acid transport
HFZ78_23270	COG1473	amidohydrolase
HFZ78_23305	COG0765	amino acid transport
HFZ78_23310	COG0765	amino acid transport
HFZ78_23315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_23320	COG1126	abc transporter atp-binding protein
HFZ78_23325	COG1113	amino acid transport
HFZ78_23330	COG3773	Cell wall hydrolase
HFZ78_23335	COG2321	neutral zinc metallopeptidase
HFZ78_23340	COG1609	Transcriptional regulator
HFZ78_23345	COG0673	inositol 2-dehydrogenase activity
HFZ78_23355	COG0673	inositol 2-dehydrogenase activity
HFZ78_23360	COG0823	Involved in the tonB-independent uptake of proteins
HFZ78_23360	COG1506	peptidase
HFZ78_23360	COG4946	Tricorn protease homolog
HFZ78_23400	COG0673	inositol 2-dehydrogenase activity
HFZ78_23405	COG0653	protein targeting
HFZ78_23430	COG1733	regulation of RNA biosynthetic process
HFZ78_23445	COG1979	alcohol dehydrogenase
HFZ78_23450	COG0500	methyltransferase
HFZ78_23465	COG2738	Putative neutral zinc metallopeptidase
HFZ78_23470	COG0561	phosphatase activity
HFZ78_23475	COG2890	protein-(glutamine-N5) methyltransferase activity
HFZ78_23480	COG0667	Aldo Keto reductase
HFZ78_23490	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HFZ78_23500	COG0697	spore germination
HFZ78_23505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_23530	COG2222	sugar isomerase
HFZ78_23535	COG0697	spore germination
HFZ78_23540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFZ78_23545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFZ78_23550	COG2188	Transcriptional regulator
HFZ78_23555	COG0129	dihydroxy-acid dehydratase activity
HFZ78_23565	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_23570	COG1486	melibiose metabolic process
HFZ78_23595	COG0395	ABC-type sugar transport system, permease component
HFZ78_23600	COG1175	transmembrane transport
HFZ78_23610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HFZ78_23615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_23620	COG2271	Major facilitator Superfamily
HFZ78_23640	COG3338	carbonate dehydratase activity
HFZ78_23655	COG1288	antiporter activity
HFZ78_23660	COG1473	amidohydrolase
HFZ78_23665	COG0583	DNA-binding transcription factor activity
HFZ78_23705	COG0667	Aldo Keto reductase
HFZ78_23740	COG4221	oxidoreductase activity
HFZ78_23755	COG2801	Transposase and inactivated derivatives
HFZ78_23795	COG0281	malic enzyme
HFZ78_23805	COG1024	Enoyl-CoA hydratase
HFZ78_23825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_23840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HFZ78_23845	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HFZ78_23875	COG2003	Belongs to the UPF0758 family
HFZ78_23885	COG4873	Protein conserved in bacteria
HFZ78_24050	COG0583	DNA-binding transcription factor activity
HFZ78_24080	COG0583	DNA-binding transcription factor activity
HFZ78_24125	COG0242	peptide deformylase activity
HFZ78_24185	COG0477	Major facilitator Superfamily
HFZ78_24200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFZ78_24235	COG0194	GDP metabolic process
HFZ78_24240	COG0450	alkyl hydroperoxide reductase
HFZ78_24255	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_24270	COG0561	phosphatase activity
HFZ78_24280	COG1278	Cold shock
HFZ78_24285	COG1114	Component of the transport system for branched-chain amino acids
HFZ78_24295	COG1011	Hydrolase
HFZ78_24310	COG0346	lactoylglutathione lyase activity
HFZ78_24360	COG0438	transferase activity, transferring glycosyl groups
HFZ78_24365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFZ78_24380	COG5337	Spore coat protein CotH
HFZ78_24390	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HFZ78_24420	COG2027	D-alanyl-D-alanine carboxypeptidase
HFZ78_24430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HFZ78_24450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFZ78_24450	COG0574	Belongs to the PEP-utilizing enzyme family
HFZ78_24455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HFZ78_24460	COG0517	IMP dehydrogenase activity
HFZ78_24530	COG2226	methyltransferase
HFZ78_24535	COG0708	Exodeoxyribonuclease III
HFZ78_24540	COG2861	carbohydrate metabolic process
HFZ78_24545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFZ78_24560	COG1657	PFAM Prenyltransferase squalene oxidase
HFZ78_24565	COG3663	DNA glycosylase
HFZ78_24570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_24575	COG1757	Na H antiporter
HFZ78_24585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFZ78_24590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFZ78_24595	COG5002	protein histidine kinase activity
HFZ78_24595	COG3850	Histidine kinase
HFZ78_24600	COG0745	RESPONSE REGULATOR receiver
HFZ78_24610	COG1024	Enoyl-CoA hydratase
HFZ78_24615	COG2045	Belongs to the ComB family
HFZ78_24625	COG1309	transcriptional regulator
HFZ78_24630	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_24635	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_24640	COG1960	acyl-CoA dehydrogenase activity
HFZ78_24650	COG2720	vancomycin resistance protein
HFZ78_24660	COG2226	methyltransferase
HFZ78_24670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_24690	COG2323	membrane
HFZ78_24695	COG0697	spore germination
HFZ78_24705	COG0778	Nitroreductase
HFZ78_24710	COG1733	regulation of RNA biosynthetic process
HFZ78_24715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_24720	COG0833	amino acid
HFZ78_24735	COG0017	Asparaginyl-tRNA synthetase
HFZ78_24760	COG3973	AAA domain
HFZ78_24775	COG1376	ErfK ybiS ycfS ynhG family protein
HFZ78_24800	COG0561	phosphatase activity
HFZ78_24815	COG0789	Transcriptional regulator
HFZ78_24820	COG3594	Acyltransferase
HFZ78_24825	COG2404	hydrolase activity, acting on ester bonds
HFZ78_24835	COG0778	Nitroreductase
HFZ78_24845	COG1136	(ABC) transporter
HFZ78_24850	COG0577	efflux transmembrane transporter activity
HFZ78_24855	COG3850	Histidine kinase
HFZ78_24855	COG5002	protein histidine kinase activity
HFZ78_24890	COG0527	aspartate kinase activity
HFZ78_24910	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFZ78_24915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFZ78_24920	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HFZ78_24925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFZ78_24930	COG4120	Belongs to the binding-protein-dependent transport system permease family
HFZ78_24940	COG0475	glutathione-regulated potassium exporter activity
HFZ78_24955	COG1418	mRNA catabolic process
HFZ78_24960	COG1525	nuclease
HFZ78_24965	COG1368	sulfuric ester hydrolase activity
HFZ78_24985	COG1960	acyl-CoA dehydrogenase activity
HFZ78_24990	COG0569	domain protein
HFZ78_24995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFZ78_25000	COG2223	nitrite transmembrane transporter activity
HFZ78_25005	COG2223	nitrite transmembrane transporter activity
HFZ78_25010	COG3383	formate dehydrogenase (NAD+) activity
HFZ78_25015	COG0243	molybdopterin cofactor binding
HFZ78_25020	COG5002	protein histidine kinase activity
HFZ78_25050	COG1346	cytolysis
HFZ78_25055	COG1380	Effector of murein hydrolase LrgA
HFZ78_25060	COG1999	signal sequence binding
HFZ78_25065	COG0488	(ABC) transporter
HFZ78_25080	COG0725	ABC transporter, periplasmic molybdate-binding protein
HFZ78_25085	COG4149	molybdate abc transporter
HFZ78_25090	COG1686	Belongs to the peptidase S11 family
HFZ78_25095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HFZ78_25095	COG0392	lysyltransferase activity
HFZ78_25110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HFZ78_25130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HFZ78_25155	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HFZ78_25185	COG0512	Glutamine amidotransferase of anthranilate synthase
HFZ78_25185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HFZ78_25190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HFZ78_25195	COG2814	Major facilitator Superfamily
HFZ78_25200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_25200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFZ78_25200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_25205	COG1105	Belongs to the carbohydrate kinase PfkB family
HFZ78_25210	COG1349	DNA-binding transcription factor activity
HFZ78_25245	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HFZ78_25250	COG1793	dna ligase
HFZ78_25250	COG3285	dna ligase
HFZ78_25255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HFZ78_25285	COG1028	Short-chain dehydrogenase reductase Sdr
HFZ78_25315	COG0523	cobalamin synthesis protein
HFZ78_25320	COG0793	Belongs to the peptidase S41A family
HFZ78_25320	COG3409	Peptidoglycan-binding domain 1 protein
HFZ78_25330	COG2217	Heavy metal translocating P-type atpase
HFZ78_25345	COG4326	sporulation control protein
HFZ78_25350	COG0515	serine threonine protein kinase
HFZ78_25370	COG4479	Belongs to the UPF0346 family
HFZ78_25380	COG1509	lysine 2,3-aminomutase activity
HFZ78_25385	COG3829	transcription factor binding
HFZ78_25390	COG0456	acetyltransferase
HFZ78_25395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFZ78_25400	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_25405	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_25410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFZ78_25415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFZ78_25420	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HFZ78_25435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HFZ78_25440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HFZ78_25460	COG2755	lipolytic protein G-D-S-L family
HFZ78_25465	COG1999	signal sequence binding
HFZ78_25485	COG1307	EDD domain protein, DegV family
HFZ78_25495	COG0805	protein transport
HFZ78_25500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFZ78_25510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HFZ78_25525	COG2310	stress, protein
HFZ78_25530	COG2310	stress, protein
HFZ78_25535	COG3853	Toxic anion resistance protein (TelA)
HFZ78_25570	COG0861	Integral membrane protein TerC family
HFZ78_25575	COG2310	stress, protein
HFZ78_25590	COG1413	lyase activity
HFZ78_25595	COG0488	(ABC) transporter
HFZ78_25600	COG1418	mRNA catabolic process
HFZ78_25605	COG1307	EDD domain protein, DegV family
HFZ78_25620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HFZ78_25630	COG1321	iron dependent repressor
HFZ78_25635	COG0551	DNA topoisomerase type I activity
HFZ78_25635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HFZ78_25645	COG1278	Cold shock
HFZ78_25655	COG0328	RNA-DNA hybrid ribonuclease activity
HFZ78_25660	COG0328	RNA-DNA hybrid ribonuclease activity
HFZ78_25675	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HFZ78_25700	COG0438	transferase activity, transferring glycosyl groups
HFZ78_25715	COG0515	serine threonine protein kinase
HFZ78_25715	COG1357	PFAM Pentapeptide repeats (8 copies)
HFZ78_25720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFZ78_25730	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HFZ78_25735	COG1755	Isoprenylcysteine carboxyl methyltransferase
HFZ78_25740	COG3424	synthase
HFZ78_25750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFZ78_25755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFZ78_25760	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HFZ78_25795	COG2151	metal-sulfur cluster biosynthetic enzyme
HFZ78_25800	COG1199	ATP-dependent helicase activity
HFZ78_25805	COG0116	Belongs to the methyltransferase superfamily
HFZ78_25820	COG4474	Belongs to the UPF0398 family
HFZ78_25830	COG3359	exonuclease
HFZ78_25835	COG1205	dead DEAH box helicase
HFZ78_25835	COG1111	helicase
HFZ78_25840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_25845	COG1151	hydroxylamine reductase activity
HFZ78_25880	COG3331	DNA recombination
HFZ78_25885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFZ78_25885	COG4499	WXG100 protein secretion system (Wss), protein YukC
HFZ78_25895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HFZ78_25900	COG3935	DnaD domain protein
HFZ78_25925	COG1199	ATP-dependent helicase activity
HFZ78_25925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFZ78_25930	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HFZ78_25935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HFZ78_25950	COG0617	tRNA 3'-terminal CCA addition
HFZ78_25955	COG0438	transferase activity, transferring glycosyl groups
HFZ78_25960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFZ78_25965	COG1803	Methylglyoxal synthase
HFZ78_25970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HFZ78_25975	COG1694	Mazg nucleotide pyrophosphohydrolase
HFZ78_25980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_25990	COG4347	Protein of unknown function (DUF1405)
HFZ78_26000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HFZ78_26015	COG5582	Belongs to the UPF0302 family
HFZ78_26020	COG0457	Tetratricopeptide repeat
HFZ78_26030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HFZ78_26035	COG0287	Prephenate dehydrogenase
HFZ78_26040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HFZ78_26050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HFZ78_26060	COG0105	UTP biosynthetic process
HFZ78_26065	COG0142	geranyltranstransferase activity
HFZ78_26070	COG2226	methyltransferase
HFZ78_26085	COG0302	gtp cyclohydrolase
HFZ78_26090	COG0776	regulation of translation
HFZ78_26095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HFZ78_26115	COG1160	GTP binding
HFZ78_26130	COG1304	FMN binding
HFZ78_26135	COG0539	negative regulation of cytoplasmic translation
HFZ78_26145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HFZ78_26155	COG2959	enzyme of heme biosynthesis
HFZ78_26160	COG3409	Peptidoglycan-binding domain 1 protein
HFZ78_26160	COG3773	Cell wall hydrolase
HFZ78_26165	COG2339	peptidase activity
HFZ78_26175	COG0492	ferredoxin-NADP+ reductase activity
HFZ78_26180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_26185	COG4862	establishment of competence for transformation
HFZ78_26190	COG1408	metallophosphoesterase
HFZ78_26210	COG3546	catalase activity
HFZ78_26220	COG4641	Protein conserved in bacteria
HFZ78_26220	COG1388	LysM domain
HFZ78_26225	COG1266	CAAX protease self-immunity
HFZ78_26230	COG0514	ATP-dependent DNA helicase (RecQ)
HFZ78_26245	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HFZ78_26255	COG0791	NLP P60 protein
HFZ78_26255	COG1388	LysM domain
HFZ78_26265	COG1595	DNA-templated transcription, initiation
HFZ78_26270	COG5002	protein histidine kinase activity
HFZ78_26275	COG0745	RESPONSE REGULATOR receiver
HFZ78_26280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFZ78_26285	COG1333	cytochrome c biogenesis protein
HFZ78_26290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_26295	COG1187	pseudouridine synthase activity
HFZ78_26300	COG0700	Nucleoside recognition
HFZ78_26305	COG2715	membrane protein required for spore maturation
HFZ78_26310	COG1686	Belongs to the peptidase S11 family
HFZ78_26315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HFZ78_26330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HFZ78_26345	COG1547	Domain of unknown function (DUF309)
HFZ78_26355	COG4086	secreted protein
HFZ78_26365	COG0697	spore germination
HFZ78_26390	COG2172	sigma factor antagonist activity
HFZ78_26395	COG1366	Belongs to the anti-sigma-factor antagonist family
HFZ78_26400	COG1686	Belongs to the peptidase S11 family
HFZ78_26420	COG4974	Belongs to the 'phage' integrase family
HFZ78_26430	COG0735	belongs to the Fur family
HFZ78_26435	COG1300	Membrane
HFZ78_26440	COG1379	DNA repair
HFZ78_26455	COG0667	Aldo Keto reductase
HFZ78_26465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFZ78_26470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFZ78_26480	COG1073	alpha beta
HFZ78_26485	COG4918	Iron-sulphur cluster biosynthesis
HFZ78_26495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFZ78_26505	COG3852	Histidine kinase
HFZ78_26510	COG0300	oxidoreductase activity
HFZ78_26515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_26520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HFZ78_26525	COG1216	Glycosyl transferase, family 2
HFZ78_26530	COG1902	pentaerythritol trinitrate reductase activity
HFZ78_26535	COG1234	tRNA 3'-trailer cleavage
HFZ78_26540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HFZ78_26545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFZ78_26550	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFZ78_26555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFZ78_26560	COG0346	lactoylglutathione lyase activity
HFZ78_26570	COG1376	ErfK ybiS ycfS ynhG family protein
HFZ78_26580	COG1126	abc transporter atp-binding protein
HFZ78_26585	COG0765	amino acid transport
HFZ78_26590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_26605	COG1703	isobutyryl-CoA mutase activity
HFZ78_26610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_26610	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_26615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFZ78_26620	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFZ78_26625	COG0022	dehydrogenase e1 component
HFZ78_26630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HFZ78_26635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFZ78_26650	COG0280	phosphate acetyltransferase
HFZ78_26655	COG3290	protein histidine kinase activity
HFZ78_26655	COG3829	transcription factor binding
HFZ78_26665	COG0584	glycerophosphoryl diester phosphodiesterase
HFZ78_26670	COG3093	addiction module antidote protein HigA
HFZ78_26675	COG0745	RESPONSE REGULATOR receiver
HFZ78_26680	COG0750	zinc metalloprotease
HFZ78_26685	COG0497	DNA recombination
HFZ78_26690	COG1438	arginine binding
HFZ78_26695	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HFZ78_26700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HFZ78_26720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HFZ78_26725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HFZ78_26730	COG1302	Protein conserved in bacteria
HFZ78_26735	COG0439	Biotin carboxylase
HFZ78_26740	COG0511	ligase activity, forming carbon-carbon bonds
HFZ78_26780	COG3854	ATPases associated with a variety of cellular activities
HFZ78_26790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_26800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFZ78_26810	COG4555	ABC transporter
HFZ78_26830	COG1138	Cytochrome C-type biogenesis protein
HFZ78_26835	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HFZ78_26860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HFZ78_26865	COG0006	proline dipeptidase activity
HFZ78_26875	COG3872	metal-dependent enzyme
HFZ78_26885	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFZ78_26890	COG1388	LysM domain
HFZ78_26890	COG0791	NLP P60 protein
HFZ78_26895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFZ78_26900	COG0095	Lipoate-protein ligase
HFZ78_26905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFZ78_26915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HFZ78_26920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HFZ78_26925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HFZ78_26935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HFZ78_26940	COG1459	type II secretion system
HFZ78_26945	COG4537	Required for transformation and DNA binding
HFZ78_26950	COG4970	Tfp pilus assembly protein FimT
HFZ78_26990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_27000	COG0011	TIGRFAM Protein of
HFZ78_27010	COG1940	carbohydrate kinase activity
HFZ78_27020	COG0457	Tetratricopeptide repeat
HFZ78_27020	COG0705	Rhomboid family
HFZ78_27040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFZ78_27045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFZ78_27065	COG0704	Plays a role in the regulation of phosphate uptake
HFZ78_27070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HFZ78_27075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HFZ78_27080	COG0581	inorganic phosphate transmembrane transporter activity
HFZ78_27085	COG0573	inorganic phosphate transmembrane transporter activity
HFZ78_27090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFZ78_27100	COG0477	Major facilitator Superfamily
HFZ78_27110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFZ78_27120	COG2839	Protein conserved in bacteria
HFZ78_27125	COG5521	maltodextrose utilization protein MalA
HFZ78_27135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HFZ78_27140	COG4709	membrane
HFZ78_27145	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HFZ78_27155	COG0735	belongs to the Fur family
HFZ78_27160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFZ78_27165	COG1121	(ABC) transporter
HFZ78_27175	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HFZ78_27190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HFZ78_27195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HFZ78_27200	COG2384	SAM-dependent methyltransferase
HFZ78_27205	COG2010	Cytochrome c
HFZ78_27210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HFZ78_27215	COG0358	DNA primase activity
HFZ78_27225	COG0517	IMP dehydrogenase activity
HFZ78_27230	COG0423	glycine-tRNA ligase activity
HFZ78_27235	COG1381	Involved in DNA repair and RecF pathway recombination
HFZ78_27245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HFZ78_27250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HFZ78_27260	COG1480	7TM receptor with intracellular HD hydrolase
HFZ78_27265	COG1702	phosphate starvation-inducible protein PhoH
HFZ78_27285	COG4864	UPF0365 protein
HFZ78_27290	COG1030	water channel activity
HFZ78_27295	COG1610	YqeY-like protein
HFZ78_27305	COG1283	sodium-dependent phosphate transmembrane transporter activity
HFZ78_27310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HFZ78_27315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HFZ78_27320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFZ78_27335	COG0443	Heat shock 70 kDa protein
HFZ78_27340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HFZ78_27345	COG1420	regulation of RNA biosynthetic process
HFZ78_27350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HFZ78_27355	COG0481	GTPase activity
HFZ78_27365	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFZ78_27375	COG0268	Binds directly to 16S ribosomal RNA
HFZ78_27380	COG1466	dna polymerase III delta subunit
HFZ78_27390	COG0658	competence protein
HFZ78_27390	COG2333	competence protein COMEC
HFZ78_27395	COG2131	deaminase
HFZ78_27400	COG1596	polysaccharide export
HFZ78_27400	COG1555	photosystem II stabilization
HFZ78_27405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HFZ78_27410	COG2226	methyltransferase
HFZ78_27415	COG0799	negative regulation of ribosome biogenesis
HFZ78_27420	COG1713	HD superfamily hydrolase involved in NAD metabolism
HFZ78_27425	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HFZ78_27430	COG1534	Rna-binding protein
HFZ78_27440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HFZ78_27445	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HFZ78_27455	COG0688	phosphatidylethanolamine metabolic process
HFZ78_27460	COG1183	phosphatidylcholine synthase activity
HFZ78_27475	COG0745	RESPONSE REGULATOR receiver
HFZ78_27500	COG0626	cystathionine gamma-synthase activity
HFZ78_27505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HFZ78_27510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HFZ78_27520	COG0768	penicillin binding
HFZ78_27525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFZ78_27530	COG0572	uridine kinase
HFZ78_27545	COG4122	O-methyltransferase activity
HFZ78_27550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HFZ78_27555	COG3906	Belongs to the UPF0473 family
HFZ78_27560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HFZ78_27565	COG4472	Bacterial protein of unknown function (DUF965)
HFZ78_27570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HFZ78_27575	COG0628	permease
HFZ78_27595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFZ78_27610	COG1104	cysteine desulfurase activity
HFZ78_27615	COG1959	2 iron, 2 sulfur cluster binding
HFZ78_27620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HFZ78_27625	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HFZ78_27630	COG1131	(ABC) transporter
HFZ78_27640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HFZ78_27650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HFZ78_27655	COG0124	histidyl-tRNA synthetase
HFZ78_27665	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFZ78_27665	COG4991	sh3 domain protein
HFZ78_27665	COG3103	Sh3 type 3 domain protein
HFZ78_27670	COG2070	2-Nitropropane dioxygenase
HFZ78_27685	COG1024	Enoyl-CoA hydratase
HFZ78_27690	COG0183	Belongs to the thiolase family
HFZ78_27695	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ78_27700	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_27705	COG1024	Enoyl-CoA hydratase
HFZ78_27735	COG3396	Phenylacetate-CoA oxygenase
HFZ78_27740	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HFZ78_27745	COG3162	membrane
HFZ78_27750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_27760	COG1490	D-aminoacyl-tRNA deacylase activity
HFZ78_27765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFZ78_27770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HFZ78_27775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HFZ78_27775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HFZ78_27780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFZ78_27780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFZ78_27790	COG2244	polysaccharide biosynthetic process
HFZ78_27795	COG2323	membrane
HFZ78_27805	COG1862	Preprotein translocase
HFZ78_27815	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HFZ78_27825	COG0632	four-way junction helicase activity
HFZ78_27850	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HFZ78_27855	COG0157	Belongs to the NadC ModD family
HFZ78_27860	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HFZ78_27865	COG1104	cysteine desulfurase activity
HFZ78_27870	COG1827	regulation of RNA biosynthetic process
HFZ78_27875	COG0077	Prephenate dehydratase
HFZ78_27880	COG4492	Belongs to the UPF0735 family
HFZ78_27885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HFZ78_27890	COG3290	protein histidine kinase activity
HFZ78_27895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HFZ78_27900	COG2868	ribosomal protein
HFZ78_27905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HFZ78_27910	COG1530	ribonuclease E activity
HFZ78_27915	COG1994	Peptidase M50
HFZ78_27920	COG0739	heme binding
HFZ78_27925	COG2894	cell division
HFZ78_27930	COG0850	regulation of cytokinetic process
HFZ78_27940	COG1792	Involved in formation and maintenance of cell shape
HFZ78_27945	COG1077	Cell shape determining protein MreB Mrl
HFZ78_27950	COG2003	Belongs to the UPF0758 family
HFZ78_27985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HFZ78_27990	COG0285	dihydrofolate synthase activity
HFZ78_27995	COG0525	valine-tRNA ligase activity
HFZ78_28010	COG1388	LysM domain
HFZ78_28010	COG1388	LysM domain
HFZ78_28015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HFZ78_28020	COG0113	porphobilinogen synthase activity
HFZ78_28030	COG0181	hydroxymethylbilane synthase activity
HFZ78_28035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFZ78_28055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HFZ78_28060	COG0470	DNA polymerase III
HFZ78_28060	COG1067	ATP-dependent peptidase activity
HFZ78_28070	COG0544	peptidyl-prolyl cis-trans isomerase activity
HFZ78_28075	COG1477	protein flavinylation
HFZ78_28075	COG0457	Tetratricopeptide repeat
HFZ78_28085	COG0622	Phosphoesterase
HFZ78_28090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HFZ78_28095	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HFZ78_28100	COG5401	PFAM Sporulation and spore germination
HFZ78_28110	COG1846	Transcriptional regulator
HFZ78_28115	COG4841	protein insertion into membrane
HFZ78_28120	COG3852	Histidine kinase
HFZ78_28125	COG4191	Histidine kinase
HFZ78_28135	COG2197	response regulator
HFZ78_28145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HFZ78_28150	COG1053	succinate dehydrogenase
HFZ78_28155	COG2009	succinate dehydrogenase
HFZ78_28160	COG1719	4-vinyl reductase, 4VR
HFZ78_28170	COG0322	excinuclease ABC activity
HFZ78_28175	COG3118	belongs to the thioredoxin family
HFZ78_28180	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFZ78_28185	COG2086	electron transfer activity
HFZ78_28190	COG1024	Enoyl-CoA hydratase
HFZ78_28195	COG1309	transcriptional regulator
HFZ78_28200	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_28205	COG3766	membrane
HFZ78_28215	COG1796	DNA polymerase
HFZ78_28215	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HFZ78_28220	COG1286	toxin biosynthetic process
HFZ78_28225	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HFZ78_28235	COG2154	pterin-4-alpha-carbinolamine dehydratase
HFZ78_28240	COG0072	phenylalanine-tRNA ligase activity
HFZ78_28240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFZ78_28245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HFZ78_28250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFZ78_28260	COG1363	Peptidase, m42
HFZ78_28270	COG0697	spore germination
HFZ78_28280	COG0756	dUTP diphosphatase activity
HFZ78_28290	COG3326	Membrane
HFZ78_28295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HFZ78_28300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HFZ78_28305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HFZ78_28310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HFZ78_28320	COG1484	DNA-dependent DNA replication
HFZ78_28325	COG3611	Membrane attachment protein
HFZ78_28330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HFZ78_28340	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HFZ78_28345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HFZ78_28350	COG0237	dephospho-CoA kinase activity
HFZ78_28355	COG1971	Probably functions as a manganese efflux pump
HFZ78_28360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HFZ78_28365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFZ78_28365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFZ78_28370	COG5002	protein histidine kinase activity
HFZ78_28375	COG0745	RESPONSE REGULATOR receiver
HFZ78_28390	COG0039	L-malate dehydrogenase activity
HFZ78_28395	COG0538	isocitrate dehydrogenase activity
HFZ78_28400	COG0372	Belongs to the citrate synthase family
HFZ78_28405	COG2707	UPF0756 membrane protein
HFZ78_28410	COG0628	permease
HFZ78_28415	COG3030	protein affecting phage T7 exclusion by the F plasmid
HFZ78_28430	COG0825	malonyl-CoA metabolic process
HFZ78_28440	COG2186	Transcriptional regulator
HFZ78_28445	COG0281	malic enzyme
HFZ78_28450	COG0587	DNA-directed DNA polymerase activity
HFZ78_28465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HFZ78_28475	COG4109	DRTGG domain
HFZ78_28485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFZ78_28490	COG0006	proline dipeptidase activity
HFZ78_28515	COG0589	response to stress
HFZ78_28525	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFZ78_28535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HFZ78_28540	COG0827	DNA restriction-modification system
HFZ78_28545	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HFZ78_28550	COG3874	Sporulation protein YtfJ
HFZ78_28560	COG1714	RDD family
HFZ78_28565	COG0616	signal peptide processing
HFZ78_28570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HFZ78_28575	COG2962	Rard protein
HFZ78_28580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ78_28590	COG0301	tRNA thio-modification
HFZ78_28595	COG1104	cysteine desulfurase activity
HFZ78_28600	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HFZ78_28605	COG1309	transcriptional regulator
HFZ78_28610	COG1956	GAF domain-containing protein
HFZ78_28615	COG0626	cystathionine gamma-synthase activity
HFZ78_28620	COG2199	diguanylate cyclase activity
HFZ78_28620	COG2203	Gaf domain
HFZ78_28625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HFZ78_28655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFZ78_28660	COG0454	-acetyltransferase
HFZ78_28665	COG0517	IMP dehydrogenase activity
HFZ78_28670	COG0123	including yeast histone deacetylase and acetoin utilization protein
HFZ78_28680	COG1605	Chorismate mutase
HFZ78_28680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HFZ78_28685	COG3118	belongs to the thioredoxin family
HFZ78_28700	COG2309	aminopeptidase activity
HFZ78_28705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HFZ78_28710	COG1674	ftsk spoiiie
HFZ78_28715	COG4848	Belongs to the UPF0354 family
HFZ78_28720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_28725	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HFZ78_28730	COG1363	Peptidase, m42
HFZ78_28735	COG5584	Small secreted protein
HFZ78_28740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFZ78_28745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HFZ78_28755	COG0510	thiamine kinase activity
HFZ78_28760	COG1523	belongs to the glycosyl hydrolase 13 family
HFZ78_28765	COG1597	lipid kinase activity
HFZ78_28775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HFZ78_28785	COG1349	DNA-binding transcription factor activity
HFZ78_28790	COG1113	amino acid transport
HFZ78_28795	COG0583	DNA-binding transcription factor activity
HFZ78_28805	COG0640	Transcriptional regulator
HFZ78_28815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HFZ78_28820	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HFZ78_28825	COG0783	Belongs to the Dps family
HFZ78_28830	COG0726	polysaccharide deacetylase
HFZ78_28835	COG1187	pseudouridine synthase activity
HFZ78_28840	COG2244	polysaccharide biosynthetic process
HFZ78_28845	COG2081	HI0933 family
HFZ78_28870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFZ78_28875	COG0495	leucyl-tRNA aminoacylation
HFZ78_28880	COG2814	Major facilitator Superfamily
HFZ78_28885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HFZ78_28905	COG1242	4 iron, 4 sulfur cluster binding
HFZ78_28910	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HFZ78_28920	COG2267	carboxylic ester hydrolase activity
HFZ78_28925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HFZ78_28930	COG0367	asparagine synthase
HFZ78_28935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HFZ78_28950	COG1506	peptidase
HFZ78_28955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFZ78_28960	COG1116	anion transmembrane transporter activity
HFZ78_28965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFZ78_28970	COG0494	nUDIX hydrolase
HFZ78_28990	COG1854	S-ribosylhomocysteine lyase activity
HFZ78_28995	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HFZ78_29000	COG0288	reversible hydration of carbon dioxide
HFZ78_29010	COG4948	Mandelate Racemase Muconate Lactonizing
HFZ78_29015	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_29020	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HFZ78_29025	COG0596	Alpha beta hydrolase
HFZ78_29030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HFZ78_29035	COG1169	isochorismate synthase
HFZ78_29040	COG1575	Belongs to the MenA family. Type 1 subfamily
HFZ78_29045	COG0058	SHG alpha-glucan phosphorylase activity
HFZ78_29050	COG0297	glycogen (starch) synthase activity
HFZ78_29055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HFZ78_29190	COG1285	pathogenesis
HFZ78_29200	COG3162	membrane
HFZ78_29205	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFZ78_29220	COG0583	DNA-binding transcription factor activity
HFZ78_29225	COG1063	alcohol dehydrogenase
HFZ78_29230	COG5577	PFAM Coat F domain
HFZ78_29245	COG5577	PFAM Coat F domain
HFZ78_29250	COG0318	PFAM AMP-dependent synthetase and ligase
HFZ78_29260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HFZ78_29275	COG0559	Belongs to the binding-protein-dependent transport system permease family
HFZ78_29305	COG0083	homoserine kinase activity
HFZ78_29310	COG0460	homoserine dehydrogenase
HFZ78_29315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFZ78_29325	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_29330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFZ78_29340	COG1012	belongs to the aldehyde dehydrogenase family
HFZ78_29345	COG3290	protein histidine kinase activity
HFZ78_29345	COG3829	transcription factor binding
HFZ78_29360	COG0531	amino acid
HFZ78_29370	COG0783	Belongs to the Dps family
HFZ78_29390	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HFZ78_29395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFZ78_29410	COG0395	ABC-type sugar transport system, permease component
HFZ78_29415	COG1175	transmembrane transport
HFZ78_29420	COG1653	transport
HFZ78_29425	COG5578	integral membrane protein
HFZ78_29435	COG1132	(ABC) transporter
HFZ78_29440	COG1132	(ABC) transporter
HFZ78_29460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HFZ78_29475	COG3250	beta-galactosidase activity
HFZ78_29480	COG3250	beta-galactosidase activity
HFZ78_29485	COG0673	inositol 2-dehydrogenase activity
HFZ78_29490	COG0673	inositol 2-dehydrogenase activity
HFZ78_29495	COG1349	DNA-binding transcription factor activity
HFZ78_29520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFZ78_29525	COG0395	ABC-type sugar transport system, permease component
HFZ78_29530	COG1175	transmembrane transport
HFZ78_29535	COG1653	transport
HFZ78_29570	COG1940	carbohydrate kinase activity
HFZ78_29575	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HFZ78_29580	COG3395	kinase activity
HFZ78_29585	COG0235	Class ii aldolase
HFZ78_29590	COG0383	alpha-mannosidase activity
HFZ78_29620	COG0395	ABC-type sugar transport system, permease component
HFZ78_29630	COG1609	Transcriptional regulator
HFZ78_29635	COG5578	integral membrane protein
HFZ78_29645	COG0383	alpha-mannosidase activity
HFZ78_29660	COG1069	ribulokinase activity
HFZ78_29680	COG1175	transmembrane transport
HFZ78_29685	COG1653	transport
HFZ78_29690	COG2207	Transcriptional regulator
HFZ78_29690	COG4753	response regulator
HFZ78_29695	COG2972	Histidine kinase
HFZ78_29700	COG1501	Belongs to the glycosyl hydrolase 31 family
HFZ78_29710	COG1175	transmembrane transport
HFZ78_29715	COG2182	Extracellular solute-binding protein
HFZ78_29720	COG3275	phosphorelay sensor kinase activity
HFZ78_29725	COG2207	Transcriptional regulator
HFZ78_29725	COG4753	response regulator
HFZ78_29730	COG1482	cell wall glycoprotein biosynthetic process
HFZ78_29735	COG2706	6-phosphogluconolactonase activity
HFZ78_29740	COG2323	membrane
HFZ78_29755	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HFZ78_29775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HFZ78_29790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HFZ78_29800	COG1215	transferase activity, transferring glycosyl groups
HFZ78_29825	COG0489	protein tyrosine kinase activity
HFZ78_29830	COG3944	biosynthesis protein
HFZ78_29840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_29850	COG0626	cystathionine gamma-synthase activity
HFZ78_29855	COG0626	cystathionine gamma-synthase activity
HFZ78_29860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HFZ78_29860	COG0646	methionine synthase
HFZ78_29865	COG0646	methionine synthase
HFZ78_29865	COG1410	methionine synthase
HFZ78_29870	COG1846	Transcriptional regulator
HFZ78_29875	COG2814	Major facilitator Superfamily
HFZ78_29880	COG0492	ferredoxin-NADP+ reductase activity
HFZ78_29885	COG0346	lactoylglutathione lyase activity
HFZ78_29890	COG2814	Major facilitator Superfamily
HFZ78_29925	COG0598	Magnesium transport protein CorA
HFZ78_29930	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HFZ78_29945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFZ78_29955	COG1113	amino acid transport
HFZ78_29960	COG1280	lysine exporter protein (LysE YggA)
HFZ78_29970	COG0463	Glycosyl transferase, family 2
HFZ78_29985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFZ78_30000	COG1979	alcohol dehydrogenase
HFZ78_30005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFZ78_30010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFZ78_30015	COG1098	S1 RNA binding domain
HFZ78_30035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HFZ78_30045	COG2032	superoxide dismutase activity
HFZ78_30055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFZ78_30065	COG5018	Exonuclease
HFZ78_30070	COG2050	protein possibly involved in aromatic compounds catabolism
HFZ78_30080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HFZ78_30085	COG3584	3D domain protein
HFZ78_30105	COG1252	NADH dehydrogenase
HFZ78_30120	COG0316	Belongs to the HesB IscA family
HFZ78_30130	COG1252	NADH dehydrogenase
HFZ78_30140	COG4837	Protein of unknown function (DUF1462)
HFZ78_30145	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HFZ78_30150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HFZ78_30155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HFZ78_30160	COG0647	UMP catabolic process
HFZ78_30165	COG2445	Protein of unknown function DUF86
HFZ78_30180	COG4470	Protein conserved in bacteria
HFZ78_30190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFZ78_30195	COG0739	heme binding
HFZ78_30205	COG3377	Domain of unknown function (DUF1805)
HFZ78_30210	COG0737	Belongs to the 5'-nucleotidase family
HFZ78_30215	COG0730	response to heat
HFZ78_30220	COG1801	Protein of unknown function DUF72
HFZ78_30225	COG0719	Fe-S assembly protein
HFZ78_30230	COG0822	iron-sulfur transferase activity
HFZ78_30235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFZ78_30240	COG0719	Fe-S assembly protein
HFZ78_30245	COG0396	ATPase activity
HFZ78_30250	COG1464	Belongs to the NlpA lipoprotein family
HFZ78_30255	COG2011	ABC-type metal ion transport system permease component
HFZ78_30260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFZ78_30265	COG2873	o-acetylhomoserine
HFZ78_30280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFZ78_30285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HFZ78_30295	COG0509	glycine decarboxylation via glycine cleavage system
HFZ78_30300	COG1393	Belongs to the ArsC family
HFZ78_30305	COG1960	acyl-CoA dehydrogenase activity
HFZ78_30310	COG0183	Belongs to the thiolase family
HFZ78_30315	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFZ78_30315	COG1024	Enoyl-CoA hydratase
HFZ78_30330	COG5577	PFAM Coat F domain
HFZ78_30345	COG1120	ATPase activity
HFZ78_30350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_30355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFZ78_30360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFZ78_30365	COG0772	Belongs to the SEDS family
HFZ78_30380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFZ78_30385	COG1910	domain protein
HFZ78_30400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HFZ78_30410	COG2205	protein histidine kinase activity
HFZ78_30415	COG0745	RESPONSE REGULATOR receiver
HFZ78_30420	COG3850	Histidine kinase
HFZ78_30420	COG5002	protein histidine kinase activity
HFZ78_30425	COG2268	Band 7 protein
HFZ78_30430	COG1585	Membrane protein implicated in regulation of membrane protease activity
HFZ78_30435	COG1126	abc transporter atp-binding protein
HFZ78_30440	COG0765	amino acid transport
HFZ78_30445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_30455	COG1607	acyl-coa hydrolase
HFZ78_30475	COG0628	permease
HFZ78_30480	COG0726	polysaccharide deacetylase
HFZ78_30505	COG5577	PFAM Coat F domain
HFZ78_30520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HFZ78_30525	COG0557	exoribonuclease II activity
HFZ78_30530	COG1647	Serine aminopeptidase, S33
HFZ78_30535	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HFZ78_30540	COG0148	phosphopyruvate hydratase activity
HFZ78_30545	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HFZ78_30555	COG0126	phosphoglycerate kinase activity
HFZ78_30575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HFZ78_30590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFZ78_30595	COG1481	regulation of sporulation
HFZ78_30600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HFZ78_30605	COG1660	Displays ATPase and GTPase activities
HFZ78_30610	COG1051	belongs to the nudix hydrolase family
HFZ78_30615	COG0492	ferredoxin-NADP+ reductase activity
HFZ78_30620	COG0457	Tetratricopeptide repeat
HFZ78_30625	COG0140	phosphoribosyl-ATP diphosphatase activity
HFZ78_30625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HFZ78_30630	COG0107	imidazoleglycerol-phosphate synthase activity
HFZ78_30635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HFZ78_30640	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HFZ78_30645	COG0131	Imidazoleglycerol-phosphate dehydratase
HFZ78_30650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HFZ78_30655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HFZ78_30660	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HFZ78_30665	COG0737	Belongs to the 5'-nucleotidase family
HFZ78_30670	COG0110	maltose O-acetyltransferase activity
HFZ78_30675	COG0546	phosphoglycolate phosphatase activity
HFZ78_30680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HFZ78_30685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HFZ78_30690	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HFZ78_30695	COG1950	PFAM Membrane protein of
HFZ78_30700	COG3595	metallopeptidase activity
HFZ78_30710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HFZ78_30715	COG0556	nucleotide-excision repair
HFZ78_30720	COG4897	Protein conserved in bacteria
HFZ78_30725	COG4145	pantothenate transmembrane transporter activity
HFZ78_30740	COG1388	LysM domain
HFZ78_30760	COG2608	mercury ion transmembrane transporter activity
HFZ78_30800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFZ78_30805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFZ78_30810	COG0765	amino acid transport
HFZ78_30815	COG1126	abc transporter atp-binding protein
HFZ78_30820	COG1294	oxidase, subunit
HFZ78_30825	COG1271	oxidase subunit
HFZ78_30830	COG3336	cytochrome c oxidase
HFZ78_30840	COG0463	Glycosyl transferase, family 2
HFZ78_30855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HFZ78_30860	COG0586	Pfam SNARE associated Golgi protein
HFZ78_30870	COG3850	Histidine kinase
HFZ78_30870	COG5002	protein histidine kinase activity
HFZ78_30875	COG0745	RESPONSE REGULATOR receiver
HFZ78_30890	COG1131	(ABC) transporter
HFZ78_30905	COG5577	PFAM Coat F domain
HFZ78_30915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFZ78_30920	COG0793	Belongs to the peptidase S41A family
HFZ78_30920	COG3409	Peptidoglycan-binding domain 1 protein
HFZ78_30925	COG3883	PFAM NLP P60 protein
HFZ78_30925	COG0791	NLP P60 protein
HFZ78_30930	COG2177	Part of the ABC transporter FtsEX involved in
HFZ78_30935	COG2884	Cell division ATP-binding protein ftsE
HFZ78_30945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_30960	COG3012	SEC-C Motif Domain Protein
HFZ78_30960	COG1405	negative regulation of cell septum assembly
HFZ78_30985	COG3005	denitrification pathway
HFZ78_30995	COG0653	protein targeting
HFZ78_31005	COG5577	PFAM Coat F domain
HFZ78_31010	COG1040	competence protein
HFZ78_31015	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HFZ78_31035	COG1307	EDD domain protein, DegV family
HFZ78_31040	COG2197	response regulator
HFZ78_31045	COG4585	Histidine kinase
HFZ78_31050	COG1739	Uncharacterized protein family UPF0029
HFZ78_31055	COG1316	TRANSCRIPTIONal
HFZ78_31060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HFZ78_31075	COG1682	transport, permease protein
HFZ78_31080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HFZ78_31085	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HFZ78_31115	COG4193	domain, Protein
HFZ78_31165	COG1316	TRANSCRIPTIONal
HFZ78_31170	COG3583	domain protein
HFZ78_31170	COG3584	3D domain protein
HFZ78_31175	COG1376	ErfK ybiS ycfS ynhG family protein
HFZ78_31270	COG1216	Glycosyl transferase, family 2
HFZ78_31345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFZ78_31350	COG0463	Glycosyl transferase, family 2
HFZ78_31370	COG1876	peptidase activity
HFZ78_31375	COG3853	Toxic anion resistance protein (TelA)
HFZ78_31380	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HFZ78_31390	COG0346	lactoylglutathione lyase activity
HFZ78_31395	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HFZ78_31400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFZ78_31415	COG0606	chelatase, subunit chli
HFZ78_31435	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HFZ78_31445	COG0243	molybdopterin cofactor binding
HFZ78_31450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HFZ78_31455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFZ78_31465	COG1136	(ABC) transporter
HFZ78_31465	COG0577	efflux transmembrane transporter activity
HFZ78_31470	COG1136	(ABC) transporter
HFZ78_31485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFZ78_31490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFZ78_31505	COG2356	endonuclease I
HFZ78_31510	COG0737	Belongs to the 5'-nucleotidase family
HFZ78_31515	COG1522	sequence-specific DNA binding
HFZ78_31520	COG0436	Aminotransferase
HFZ78_31525	COG3706	GGDEF domain
HFZ78_31530	COG2252	PERMEase
HFZ78_31565	COG2222	sugar isomerase
HFZ78_31575	COG2222	sugar isomerase
HFZ78_31580	COG2814	Major facilitator Superfamily