locus-tag	class	description
CIB87_00065	COG2815	serine threonine protein kinase
CIB87_00065	COG0515	serine threonine protein kinase
CIB87_00110	COG3069	C4-dicarboxylate transmembrane transporter activity
CIB87_00115	COG2329	Antibiotic biosynthesis monooxygenase
CIB87_00120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIB87_00125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CIB87_00140	COG1309	transcriptional regulator
CIB87_00155	COG2972	Histidine kinase
CIB87_00170	COG1234	tRNA 3'-trailer cleavage
CIB87_00175	COG0095	Lipoate-protein ligase
CIB87_00180	COG0318	PFAM AMP-dependent synthetase and ligase
CIB87_00185	COG1024	Enoyl-CoA hydratase
CIB87_00300	COG0501	Belongs to the peptidase M48B family
CIB87_00305	COG2224	Isocitrate lyase
CIB87_00315	COG0823	Involved in the tonB-independent uptake of proteins
CIB87_00315	COG1506	peptidase
CIB87_00315	COG4946	Tricorn protease homolog
CIB87_00320	COG0398	Pfam SNARE associated Golgi protein
CIB87_00325	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_00330	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CIB87_00335	COG1074	ATP-dependent DNA helicase activity
CIB87_00340	COG0420	3'-5' exonuclease activity
CIB87_00345	COG0419	ATPase involved in DNA repair
CIB87_00350	COG1403	HNH endonuclease
CIB87_00385	COG2311	Membrane
CIB87_00400	COG0367	asparagine synthase
CIB87_00415	COG1562	ergosterol biosynthetic process
CIB87_00420	COG0347	Belongs to the P(II) protein family
CIB87_00425	COG0004	ammonium transporteR
CIB87_00430	COG1874	Beta-galactosidase
CIB87_00430	COG0366	Alpha amylase catalytic
CIB87_00435	COG1609	Transcriptional regulator
CIB87_00440	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_00445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CIB87_00450	COG4187	Peptidase family M20/M25/M40
CIB87_00455	COG0833	amino acid
CIB87_00460	COG3829	transcription factor binding
CIB87_00465	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_00470	COG1666	GTP binding
CIB87_00475	COG2996	Protein conserved in bacteria
CIB87_00485	COG1307	EDD domain protein, DegV family
CIB87_00490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_00500	COG0561	phosphatase activity
CIB87_00505	COG2151	metal-sulfur cluster biosynthetic enzyme
CIB87_00510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CIB87_00515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CIB87_00520	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CIB87_00525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CIB87_00545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CIB87_00560	COG0542	response to heat
CIB87_00575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CIB87_00580	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CIB87_00585	COG2084	Dehydrogenase
CIB87_00595	COG2267	carboxylic ester hydrolase activity
CIB87_00615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIB87_00620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CIB87_00625	COG5504	Zn-dependent protease
CIB87_00630	COG0444	Belongs to the ABC transporter superfamily
CIB87_00635	COG4608	Belongs to the ABC transporter superfamily
CIB87_00645	COG0601	transmembrane transport
CIB87_00660	COG0180	Tryptophanyl-tRNA synthetase
CIB87_00670	COG4166	transmembrane transport
CIB87_00675	COG0601	transmembrane transport
CIB87_00680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CIB87_00685	COG0444	Belongs to the ABC transporter superfamily
CIB87_00690	COG4608	Belongs to the ABC transporter superfamily
CIB87_00695	COG0456	acetyltransferase
CIB87_00700	COG1113	amino acid transport
CIB87_00705	COG0531	amino acid
CIB87_00710	COG1393	Belongs to the ArsC family
CIB87_00715	COG0583	DNA-binding transcription factor activity
CIB87_00730	COG0861	Integral membrane protein TerC family
CIB87_00740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIB87_00750	COG1164	Oligoendopeptidase f
CIB87_00765	COG2346	COG2346, Truncated hemoglobins
CIB87_00770	COG0741	lytic transglycosylase activity
CIB87_00775	COG4116	CYTH
CIB87_00785	COG2357	RelA SpoT domain protein
CIB87_00790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CIB87_00795	COG0564	pseudouridine synthase activity
CIB87_00800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CIB87_00805	COG2239	Acts as a magnesium transporter
CIB87_00810	COG0475	glutathione-regulated potassium exporter activity
CIB87_00810	COG0569	domain protein
CIB87_00860	COG0210	DNA helicase
CIB87_00870	COG2323	membrane
CIB87_00875	COG2153	protein acetylation
CIB87_00885	COG2382	esterase
CIB87_00900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CIB87_00910	COG1737	Transcriptional regulator
CIB87_00915	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CIB87_00920	COG1070	Carbohydrate kinase
CIB87_00925	COG1953	Uracil, thiamine, allantoin
CIB87_00945	COG1522	sequence-specific DNA binding
CIB87_00965	COG3142	Participates in the control of copper homeostasis
CIB87_00970	COG1113	amino acid transport
CIB87_00980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIB87_00985	COG1309	transcriptional regulator
CIB87_00990	COG3711	transcriptional antiterminator
CIB87_00990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIB87_00995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CIB87_01000	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CIB87_01005	COG1447	Phosphotransferase system cellobiose-specific component IIA
CIB87_01010	COG1486	melibiose metabolic process
CIB87_01015	COG3275	phosphorelay sensor kinase activity
CIB87_01020	COG3279	Response regulator of the LytR AlgR family
CIB87_01030	COG1346	cytolysis
CIB87_01045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CIB87_01050	COG0243	molybdopterin cofactor binding
CIB87_01055	COG2223	nitrite transmembrane transporter activity
CIB87_01060	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CIB87_01075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CIB87_01085	COG0028	Belongs to the TPP enzyme family
CIB87_01085	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CIB87_01100	COG3527	Alpha-acetolactate decarboxylase
CIB87_01105	COG0028	Belongs to the TPP enzyme family
CIB87_01115	COG4895	conserved protein (DUF2196)
CIB87_01125	COG1733	regulation of RNA biosynthetic process
CIB87_01130	COG2814	Major facilitator Superfamily
CIB87_01150	COG3052	prosthetic group binding
CIB87_01165	COG0784	Response regulator, receiver
CIB87_01170	COG4191	Histidine kinase
CIB87_01175	COG2066	Belongs to the glutaminase family
CIB87_01180	COG1115	amino acid carrier protein
CIB87_01185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CIB87_01195	COG4297	protein containing double-stranded beta helix domain
CIB87_01200	COG0531	amino acid
CIB87_01210	COG1607	acyl-coa hydrolase
CIB87_01215	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CIB87_01230	COG0390	transport system, permease component
CIB87_01235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CIB87_01250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIB87_01255	COG1136	(ABC) transporter
CIB87_01260	COG0577	efflux transmembrane transporter activity
CIB87_01270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CIB87_01275	COG1063	alcohol dehydrogenase
CIB87_01290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CIB87_01295	COG0833	amino acid
CIB87_01305	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CIB87_01310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CIB87_01320	COG0861	Integral membrane protein TerC family
CIB87_01325	COG1301	dicarboxylic acid transport
CIB87_01330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CIB87_01335	COG3290	protein histidine kinase activity
CIB87_01375	COG1476	TRANSCRIPTIONal
CIB87_01385	COG1368	sulfuric ester hydrolase activity
CIB87_01400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIB87_01405	COG2040	homocysteine
CIB87_01410	COG0179	Fumarylacetoacetate (FAA) hydrolase
CIB87_01425	COG2851	Citrate transporter
CIB87_01430	COG3290	protein histidine kinase activity
CIB87_01435	COG4565	transcriptional regulatory protein
CIB87_01440	COG3181	Tripartite tricarboxylate transporter family receptor
CIB87_01450	COG0583	DNA-binding transcription factor activity
CIB87_01455	COG3180	Ammonia monooxygenase
CIB87_01460	COG2226	methyltransferase
CIB87_01465	COG4176	ABC-type proline glycine betaine transport system permease component
CIB87_01470	COG1309	transcriptional regulator
CIB87_01490	COG0531	amino acid
CIB87_01495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CIB87_01500	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CIB87_01505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIB87_01510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIB87_01540	COG1737	Transcriptional regulator
CIB87_01545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CIB87_01545	COG1263	PTS System
CIB87_01555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CIB87_01560	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CIB87_01565	COG1116	anion transmembrane transporter activity
CIB87_01570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIB87_01575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CIB87_01580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CIB87_01585	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CIB87_01590	COG1733	regulation of RNA biosynthetic process
CIB87_01625	COG1511	domain protein
CIB87_01630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CIB87_01635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CIB87_01640	COG1733	regulation of RNA biosynthetic process
CIB87_01650	COG1132	(ABC) transporter
CIB87_01655	COG1132	(ABC) transporter
CIB87_01665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CIB87_01670	COG3162	membrane
CIB87_01680	COG1414	Transcriptional regulator
CIB87_01685	COG0656	L-ascorbic acid biosynthetic process
CIB87_01690	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CIB87_01695	COG1846	Transcriptional regulator
CIB87_01700	COG1566	PFAM secretion protein HlyD family protein
CIB87_01705	COG2814	Major facilitator Superfamily
CIB87_01710	COG0655	NAD(P)H dehydrogenase (quinone) activity
CIB87_01725	COG1609	Transcriptional regulator
CIB87_01730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIB87_01740	COG1129	ABC transporter
CIB87_01745	COG1172	Belongs to the binding-protein-dependent transport system permease family
CIB87_01750	COG1879	ABC-type sugar transport system periplasmic component
CIB87_01755	COG3584	3D domain protein
CIB87_01755	COG3583	domain protein
CIB87_01760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CIB87_01765	COG1653	transport
CIB87_01790	COG0745	RESPONSE REGULATOR receiver
CIB87_01790	COG3706	GGDEF domain
CIB87_01810	COG0745	RESPONSE REGULATOR receiver
CIB87_01815	COG5002	protein histidine kinase activity
CIB87_01850	COG0402	S-adenosylhomocysteine deaminase activity
CIB87_01855	COG2252	PERMEase
CIB87_01860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CIB87_01870	COG1263	PTS System
CIB87_01870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CIB87_01875	COG0366	Alpha amylase catalytic
CIB87_01880	COG2188	Transcriptional regulator
CIB87_01885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CIB87_01890	COG1984	allophanate hydrolase subunit 2
CIB87_01895	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CIB87_01900	COG1914	H( )-stimulated, divalent metal cation uptake system
CIB87_01905	COG1272	protein, Hemolysin III
CIB87_01920	COG0778	Nitroreductase
CIB87_01925	COG0628	permease
CIB87_01950	COG0439	Biotin carboxylase
CIB87_01965	COG0531	amino acid
CIB87_01970	COG0402	S-adenosylhomocysteine deaminase activity
CIB87_01980	COG1131	(ABC) transporter
CIB87_01985	COG1278	Cold shock
CIB87_01990	COG2910	NAD(P)H-binding
CIB87_01995	COG0673	inositol 2-dehydrogenase activity
CIB87_02000	COG0450	alkyl hydroperoxide reductase
CIB87_02005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIB87_02040	COG1785	Belongs to the alkaline phosphatase family
CIB87_02080	COG0546	phosphoglycolate phosphatase activity
CIB87_02085	COG3316	Transposase and inactivated derivatives
CIB87_02100	COG1448	Aminotransferase
CIB87_02110	COG1113	amino acid transport
CIB87_02120	COG1733	regulation of RNA biosynthetic process
CIB87_02130	COG0077	Prephenate dehydratase
CIB87_02135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CIB87_02140	COG1335	isochorismatase
CIB87_02155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CIB87_02160	COG0066	3-isopropylmalate dehydratase activity
CIB87_02180	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_02190	COG1942	4-Oxalocrotonate Tautomerase
CIB87_02195	COG0583	DNA-binding transcription factor activity
CIB87_02205	COG1733	regulation of RNA biosynthetic process
CIB87_02215	COG1902	pentaerythritol trinitrate reductase activity
CIB87_02230	COG3316	Transposase and inactivated derivatives
CIB87_02240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIB87_02245	COG2076	Multidrug Resistance protein
CIB87_02250	COG2076	Multidrug Resistance protein
CIB87_02320	COG1649	PFAM Uncharacterised BCR, COG1649
CIB87_02325	COG1737	Transcriptional regulator
CIB87_02345	COG1486	melibiose metabolic process
CIB87_02355	COG1447	Phosphotransferase system cellobiose-specific component IIA
CIB87_02365	COG2971	BadF BadG BcrA BcrD
CIB87_02370	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CIB87_02385	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CIB87_02400	COG1376	ErfK ybiS ycfS ynhG family protein
CIB87_02405	COG2226	methyltransferase
CIB87_02410	COG0583	DNA-binding transcription factor activity
CIB87_02420	COG0667	Aldo Keto reductase
CIB87_02430	COG2323	membrane
CIB87_02440	COG0154	amidase activity
CIB87_02450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CIB87_02495	COG1733	regulation of RNA biosynthetic process
CIB87_02510	COG0385	Bile acid
CIB87_02520	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CIB87_02525	COG4191	Histidine kinase
CIB87_02530	COG0784	Response regulator, receiver
CIB87_02545	COG0791	NLP P60 protein
CIB87_02545	COG1388	LysM domain
CIB87_02550	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIB87_02555	COG2385	sporulation resulting in formation of a cellular spore
CIB87_02560	COG0656	L-ascorbic acid biosynthetic process
CIB87_02575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CIB87_02580	COG4948	Mandelate Racemase Muconate Lactonizing
CIB87_02610	COG0477	Major facilitator Superfamily
CIB87_02615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIB87_02625	COG0640	Transcriptional regulator
CIB87_02630	COG5658	integral membrane protein
CIB87_02655	COG5001	Diguanylate cyclase
CIB87_02655	COG3300	MHYT domain
CIB87_02660	COG0302	gtp cyclohydrolase
CIB87_02675	COG5001	Diguanylate cyclase
CIB87_02675	COG3300	MHYT domain
CIB87_02685	COG2200	EAL domain
CIB87_02705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIB87_02735	COG4640	response to antibiotic
CIB87_02760	COG4640	response to antibiotic
CIB87_02770	COG1472	Belongs to the glycosyl hydrolase 3 family
CIB87_02790	COG1674	ftsk spoiiie
CIB87_02810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CIB87_02825	COG1396	sequence-specific DNA binding
CIB87_02830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIB87_02835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIB87_02845	COG4464	protein tyrosine phosphatase activity
CIB87_02850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CIB87_02860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CIB87_02865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CIB87_02870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CIB87_02875	COG0438	transferase activity, transferring glycosyl groups
CIB87_02880	COG0463	Glycosyl transferase, family 2
CIB87_02880	COG1216	Glycosyl transferase, family 2
CIB87_02890	COG0110	maltose O-acetyltransferase activity
CIB87_02895	COG0438	transferase activity, transferring glycosyl groups
CIB87_02910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CIB87_02920	COG3944	biosynthesis protein
CIB87_02925	COG0489	protein tyrosine kinase activity
CIB87_02930	COG1316	TRANSCRIPTIONal
CIB87_02935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CIB87_02945	COG4464	protein tyrosine phosphatase activity
CIB87_02960	COG0028	Belongs to the TPP enzyme family
CIB87_02965	COG0069	glutamate synthase activity
CIB87_02975	COG2084	Dehydrogenase
CIB87_03005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CIB87_03010	COG2146	nitrite reductase [NAD(P)H] activity
CIB87_03020	COG2116	formate transmembrane transporter activity
CIB87_03030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIB87_03035	COG4975	Glucose uptake
CIB87_03055	COG0534	Mate efflux family protein
CIB87_03065	COG1316	TRANSCRIPTIONal
CIB87_03075	COG0598	Magnesium transport protein CorA
CIB87_03080	COG1404	Belongs to the peptidase S8 family
CIB87_03110	COG4821	SIS domain
CIB87_03120	COG0363	glucosamine-6-phosphate deaminase activity
CIB87_03125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CIB87_03130	COG1263	PTS System
CIB87_03130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CIB87_03130	COG2190	(PTS) system
CIB87_03140	COG1811	Na channel or pump
CIB87_03190	COG1131	(ABC) transporter
CIB87_03195	COG1253	flavin adenine dinucleotide binding
CIB87_03200	COG0789	Transcriptional regulator
CIB87_03210	COG0346	lactoylglutathione lyase activity
CIB87_03215	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CIB87_03215	COG2105	PFAM AIG2 family protein
CIB87_03255	COG0840	transmembrane signaling receptor activity
CIB87_03275	COG4187	Peptidase family M20/M25/M40
CIB87_03290	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CIB87_03290	COG0456	acetyltransferase
CIB87_03305	COG2252	PERMEase
CIB87_03315	COG3279	Response regulator of the LytR AlgR family
CIB87_03320	COG4555	ABC transporter
CIB87_03325	COG1668	transmembrane transport
CIB87_03335	COG0789	Transcriptional regulator
CIB87_03340	COG1846	Transcriptional regulator
CIB87_03345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIB87_03345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIB87_03365	COG1785	Belongs to the alkaline phosphatase family
CIB87_03370	COG3279	Response regulator of the LytR AlgR family
CIB87_03375	COG0784	Response regulator, receiver
CIB87_03375	COG2205	protein histidine kinase activity
CIB87_03380	COG0861	Integral membrane protein TerC family
CIB87_03385	COG1191	sigma factor activity
CIB87_03415	COG3243	poly(R)-hydroxyalkanoic acid synthase
CIB87_03425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CIB87_03440	COG2186	Transcriptional regulator
CIB87_03445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CIB87_03455	COG0247	lactate metabolic process
CIB87_03460	COG1139	Iron-sulfur cluster binding protein
CIB87_03465	COG1556	Lactate utilization protein
CIB87_03475	COG5002	protein histidine kinase activity
CIB87_03480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CIB87_03485	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CIB87_03490	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CIB87_03495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIB87_03500	COG0436	Aminotransferase
CIB87_03505	COG1850	ribulose-bisphosphate carboxylase activity
CIB87_03510	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CIB87_03515	COG0235	Class ii aldolase
CIB87_03520	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CIB87_03530	COG1129	ABC transporter
CIB87_03535	COG1172	Belongs to the binding-protein-dependent transport system permease family
CIB87_03560	COG1846	Transcriptional regulator
CIB87_03570	COG4191	Histidine kinase
CIB87_03580	COG0542	response to heat
CIB87_03595	COG0300	oxidoreductase activity
CIB87_03600	COG0697	spore germination
CIB87_03620	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CIB87_03625	COG0720	synthase
CIB87_03635	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CIB87_03640	COG0702	epimerase
CIB87_03650	COG4873	Protein conserved in bacteria
CIB87_03670	COG3773	Cell wall hydrolase
CIB87_03710	COG1410	methionine synthase
CIB87_03710	COG0646	methionine synthase
CIB87_03715	COG0646	methionine synthase
CIB87_03715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CIB87_03720	COG3949	Membrane
CIB87_03730	COG0307	riboflavin synthase, alpha
CIB87_03740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CIB87_03750	COG3711	transcriptional antiterminator
CIB87_03755	COG1263	PTS System
CIB87_03755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CIB87_03755	COG2190	(PTS) system
CIB87_03770	COG1346	cytolysis
CIB87_03780	COG0583	DNA-binding transcription factor activity
CIB87_03790	COG0456	acetyltransferase
CIB87_03795	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_03800	COG0778	Nitroreductase
CIB87_03805	COG0436	Aminotransferase
CIB87_03825	COG0784	Response regulator, receiver
CIB87_03825	COG0835	chemotaxis
CIB87_03835	COG1376	ErfK ybiS ycfS ynhG family protein
CIB87_03840	COG0248	Ppx GppA phosphatase
CIB87_03855	COG1408	metallophosphoesterase
CIB87_03860	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_03865	COG2200	EAL domain
CIB87_03880	COG4703	Protein of unknown function (DUF1797)
CIB87_03885	COG0517	IMP dehydrogenase activity
CIB87_03890	COG0583	DNA-binding transcription factor activity
CIB87_03895	COG2171	N-acyltransferase activity
CIB87_03900	COG1473	amidohydrolase
CIB87_03910	COG0668	transmembrane transport
CIB87_03915	COG0450	alkyl hydroperoxide reductase
CIB87_03920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIB87_03925	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CIB87_03930	COG1132	(ABC) transporter
CIB87_03935	COG1132	(ABC) transporter
CIB87_03940	COG0569	domain protein
CIB87_03945	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CIB87_03955	COG0561	phosphatase activity
CIB87_03980	COG0022	dehydrogenase e1 component
CIB87_03985	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIB87_04000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CIB87_04010	COG1982	Orn Lys Arg decarboxylase major
CIB87_04015	COG4476	Belongs to the UPF0223 family
CIB87_04025	COG4493	Belongs to the UPF0637 family
CIB87_04035	COG0483	inositol monophosphate 1-phosphatase activity
CIB87_04060	COG4896	Protein conserved in bacteria
CIB87_04075	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CIB87_04080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CIB87_04085	COG4838	Belongs to the UPF0358 family
CIB87_04090	COG0772	Belongs to the SEDS family
CIB87_04095	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CIB87_04100	COG1612	heme a metabolic process
CIB87_04105	COG0109	protoheme IX farnesyltransferase activity
CIB87_04130	COG3336	cytochrome c oxidase
CIB87_04140	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CIB87_04145	COG2340	Cysteine-rich secretory protein family
CIB87_04155	COG2738	Putative neutral zinc metallopeptidase
CIB87_04160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_04165	COG1694	Mazg nucleotide pyrophosphohydrolase
CIB87_04170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CIB87_04175	COG1803	Methylglyoxal synthase
CIB87_04180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CIB87_04185	COG0438	transferase activity, transferring glycosyl groups
CIB87_04190	COG0617	tRNA 3'-terminal CCA addition
CIB87_04195	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CIB87_04195	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CIB87_04205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CIB87_04210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CIB87_04215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CIB87_04215	COG1199	ATP-dependent helicase activity
CIB87_04235	COG0436	Aminotransferase
CIB87_04240	COG0017	Asparaginyl-tRNA synthetase
CIB87_04245	COG3935	DnaD domain protein
CIB87_04250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CIB87_04260	COG4499	WXG100 protein secretion system (Wss), protein YukC
CIB87_04260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIB87_04265	COG3331	DNA recombination
CIB87_04300	COG5337	Spore coat protein CotH
CIB87_04315	COG0626	cystathionine gamma-synthase activity
CIB87_04320	COG0626	cystathionine gamma-synthase activity
CIB87_04335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CIB87_04345	COG1278	Cold shock
CIB87_04360	COG3706	GGDEF domain
CIB87_04370	COG1205	dead DEAH box helicase
CIB87_04370	COG1111	helicase
CIB87_04375	COG3359	exonuclease
CIB87_04385	COG4474	Belongs to the UPF0398 family
CIB87_04390	COG3599	regulation of cell shape
CIB87_04420	COG2197	response regulator
CIB87_04425	COG0366	Alpha amylase catalytic
CIB87_04430	COG0116	Belongs to the methyltransferase superfamily
CIB87_04450	COG1199	ATP-dependent helicase activity
CIB87_04455	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CIB87_04460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIB87_04465	COG2233	PERMEase
CIB87_04470	COG0583	DNA-binding transcription factor activity
CIB87_04475	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_04490	COG3424	synthase
CIB87_04495	COG1755	Isoprenylcysteine carboxyl methyltransferase
CIB87_04500	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CIB87_04505	COG3541	Predicted nucleotidyltransferase
CIB87_04530	COG0328	RNA-DNA hybrid ribonuclease activity
CIB87_04535	COG0328	RNA-DNA hybrid ribonuclease activity
CIB87_04560	COG2814	Major facilitator Superfamily
CIB87_04570	COG2233	PERMEase
CIB87_04575	COG2362	D-Aminopeptidase
CIB87_04580	COG0601	transmembrane transport
CIB87_04585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CIB87_04590	COG0444	Belongs to the ABC transporter superfamily
CIB87_04595	COG4166	transmembrane transport
CIB87_04600	COG1619	proteins homologs of microcin C7 resistance protein MccF
CIB87_04605	COG0791	NLP P60 protein
CIB87_04610	COG4608	Belongs to the ABC transporter superfamily
CIB87_04635	COG3689	TIGRFAM TIGR03943 family protein
CIB87_04640	COG0701	Predicted permease
CIB87_04645	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CIB87_04650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIB87_04655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIB87_04660	COG1120	ATPase activity
CIB87_04685	COG2197	response regulator
CIB87_04690	COG4585	Histidine kinase
CIB87_04695	COG3239	Fatty acid desaturase
CIB87_04700	COG2205	protein histidine kinase activity
CIB87_04710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIB87_04725	COG1388	LysM domain
CIB87_04725	COG0791	NLP P60 protein
CIB87_04730	COG1819	glycosyl
CIB87_04745	COG2814	Major facilitator Superfamily
CIB87_04755	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_04760	COG3964	amidohydrolase
CIB87_04780	COG2188	Transcriptional regulator
CIB87_04790	COG0434	BtpA family
CIB87_04805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CIB87_04810	COG1404	Belongs to the peptidase S8 family
CIB87_04820	COG1846	Transcriptional regulator
CIB87_04825	COG1566	PFAM secretion protein HlyD family protein
CIB87_04830	COG2814	Major facilitator Superfamily
CIB87_04855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIB87_04860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIB87_04865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIB87_04870	COG1120	ATPase activity
CIB87_04885	COG2814	Major facilitator Superfamily
CIB87_04935	COG0745	RESPONSE REGULATOR receiver
CIB87_04940	COG2205	protein histidine kinase activity
CIB87_04945	COG0697	spore germination
CIB87_04950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIB87_04955	COG0789	Transcriptional regulator
CIB87_04960	COG0697	spore germination
CIB87_04970	COG1846	Transcriptional regulator
CIB87_04970	COG0456	acetyltransferase
CIB87_04975	COG2271	Major facilitator Superfamily
CIB87_04985	COG3011	Protein conserved in bacteria
CIB87_04995	COG1522	sequence-specific DNA binding
CIB87_05005	COG2318	DinB family
CIB87_05055	COG0583	DNA-binding transcription factor activity
CIB87_05080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CIB87_05085	COG1733	regulation of RNA biosynthetic process
CIB87_05090	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CIB87_05100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIB87_05105	COG4638	Rieske (2fe-2S)
CIB87_05110	COG4175	Glycine betaine
CIB87_05110	COG3448	diguanylate cyclase activity
CIB87_05125	COG0469	pyruvate kinase activity
CIB87_05130	COG0784	Response regulator, receiver
CIB87_05130	COG2205	protein histidine kinase activity
CIB87_05135	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CIB87_05140	COG2208	phosphoserine phosphatase activity
CIB87_05150	COG0531	amino acid
CIB87_05160	COG1011	Hydrolase
CIB87_05165	COG0405	Gamma-glutamyltransferase
CIB87_05170	COG1621	beta-fructofuranosidase activity
CIB87_05175	COG1621	beta-fructofuranosidase activity
CIB87_05180	COG2193	ferroxidase activity
CIB87_05185	COG0477	Major facilitator Superfamily
CIB87_05195	COG0156	8-amino-7-oxononanoate synthase activity
CIB87_05200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIB87_05210	COG2814	Major facilitator Superfamily
CIB87_05230	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_05235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIB87_05245	COG1280	lysine exporter protein (LysE YggA)
CIB87_05250	COG1113	amino acid transport
CIB87_05260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CIB87_05280	COG1113	amino acid transport
CIB87_05300	COG1609	Transcriptional regulator
CIB87_05305	COG2223	nitrite transmembrane transporter activity
CIB87_05315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CIB87_05320	COG1621	beta-fructofuranosidase activity
CIB87_05325	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CIB87_05325	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CIB87_05330	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIB87_05335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CIB87_05340	COG3715	PTS system
CIB87_05345	COG3716	PTS system mannose fructose sorbose family IID component
CIB87_05350	COG1621	beta-fructofuranosidase activity
CIB87_05355	COG0024	Methionine aminopeptidase
CIB87_05365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CIB87_05375	COG0656	L-ascorbic acid biosynthetic process
CIB87_05380	COG2986	histidine ammonia-lyase
CIB87_05390	COG1228	amidohydrolase
CIB87_05395	COG0010	Belongs to the arginase family
CIB87_05400	COG1846	Transcriptional regulator
CIB87_05410	COG0473	3-isopropylmalate dehydrogenase activity
CIB87_05415	COG1288	antiporter activity
CIB87_05420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CIB87_05445	COG0789	Transcriptional regulator
CIB87_05455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIB87_05475	COG2364	Membrane
CIB87_05480	COG1846	Transcriptional regulator
CIB87_05485	COG0456	acetyltransferase
CIB87_05490	COG0640	Transcriptional regulator
CIB87_05550	COG0574	Belongs to the PEP-utilizing enzyme family
CIB87_05550	COG3848	Pyruvate phosphate dikinase
CIB87_05555	COG1309	transcriptional regulator
CIB87_05560	COG2814	Major facilitator Superfamily
CIB87_05570	COG0494	nUDIX hydrolase
CIB87_05590	COG0791	NLP P60 protein
CIB87_05590	COG1388	LysM domain
CIB87_05595	COG0772	Belongs to the SEDS family
CIB87_05615	COG2318	DinB family
CIB87_05655	COG0583	DNA-binding transcription factor activity
CIB87_05675	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_05700	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CIB87_05710	COG0697	spore germination
CIB87_05715	COG4977	sequence-specific DNA binding
CIB87_05740	COG0387	Pfam Sodium calcium exchanger
CIB87_05745	COG0318	PFAM AMP-dependent synthetase and ligase
CIB87_05770	COG1309	transcriptional regulator
CIB87_05775	COG0861	Integral membrane protein TerC family
CIB87_05790	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_05800	COG1522	sequence-specific DNA binding
CIB87_05805	COG3813	Protein conserved in bacteria
CIB87_05825	COG2076	Multidrug Resistance protein
CIB87_05885	COG1278	Cold shock
CIB87_05895	COG0513	Belongs to the DEAD box helicase family
CIB87_05900	COG1278	Cold shock
CIB87_05910	COG0028	Belongs to the TPP enzyme family
CIB87_05955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CIB87_05960	COG2076	Multidrug Resistance protein
CIB87_05965	COG0517	IMP dehydrogenase activity
CIB87_05970	COG2323	membrane
CIB87_05980	COG2807	transmembrane transport
CIB87_05990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CIB87_05995	COG0583	DNA-binding transcription factor activity
CIB87_06000	COG0747	negative chemotaxis
CIB87_06005	COG0601	transmembrane transport
CIB87_06010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CIB87_06015	COG0444	Belongs to the ABC transporter superfamily
CIB87_06020	COG4608	Belongs to the ABC transporter superfamily
CIB87_06025	COG0534	Mate efflux family protein
CIB87_06045	COG2172	sigma factor antagonist activity
CIB87_06050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIB87_06055	COG0477	Major facilitator Superfamily
CIB87_06060	COG1414	Transcriptional regulator
CIB87_06075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CIB87_06080	COG0129	dihydroxy-acid dehydratase activity
CIB87_06085	COG2610	gluconate transmembrane transporter activity
CIB87_06090	COG3858	chitin binding
CIB87_06090	COG1388	LysM domain
CIB87_06095	COG1376	ErfK ybiS ycfS ynhG family protein
CIB87_06130	COG2226	methyltransferase
CIB87_06140	COG1733	regulation of RNA biosynthetic process
CIB87_06145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIB87_06155	COG2207	Transcriptional regulator
CIB87_06165	COG2376	Dihydroxyacetone kinase
CIB87_06180	COG3239	Fatty acid desaturase
CIB87_06255	COG0789	Transcriptional regulator
CIB87_06285	COG0318	PFAM AMP-dependent synthetase and ligase
CIB87_06290	COG2072	flavoprotein involved in K transport
CIB87_06295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CIB87_06305	COG0822	iron-sulfur transferase activity
CIB87_06320	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CIB87_06340	COG1757	Na H antiporter
CIB87_06370	COG2217	Heavy metal translocating P-type atpase
CIB87_06375	COG0640	Transcriptional regulator
CIB87_06405	COG2217	Heavy metal translocating P-type atpase
CIB87_06450	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_06465	COG1278	Cold shock
CIB87_06515	COG2002	toxin-antitoxin pair type II binding
CIB87_06530	COG0697	spore germination
CIB87_06535	COG0531	amino acid
CIB87_06550	COG0252	asparaginase activity
CIB87_06555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CIB87_06560	COG0569	domain protein
CIB87_06590	COG0697	spore germination
CIB87_06630	COG0697	spore germination
CIB87_06640	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CIB87_06645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CIB87_06650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CIB87_06655	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CIB87_06660	COG1280	lysine exporter protein (LysE YggA)
CIB87_06675	COG1757	Na H antiporter
CIB87_06700	COG1027	Aspartate ammonia-lyase
CIB87_06705	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_06720	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CIB87_06725	COG0640	Transcriptional regulator
CIB87_06735	COG0640	Transcriptional regulator
CIB87_06740	COG0346	lactoylglutathione lyase activity
CIB87_06765	COG1335	isochorismatase
CIB87_06770	COG0138	bifunctional purine biosynthesis protein purh
CIB87_06775	COG0456	acetyltransferase
CIB87_06780	COG2095	MarC family integral membrane protein
CIB87_06865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIB87_06875	COG4282	regulation of fungal-type cell wall biogenesis
CIB87_06885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CIB87_06885	COG1017	nitric oxide dioxygenase activity
CIB87_06895	COG0574	Belongs to the PEP-utilizing enzyme family
CIB87_06895	COG3848	Pyruvate phosphate dikinase
CIB87_06900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CIB87_06910	COG0601	transmembrane transport
CIB87_06920	COG0444	Belongs to the ABC transporter superfamily
CIB87_06925	COG4608	Belongs to the ABC transporter superfamily
CIB87_06935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CIB87_06950	COG3852	Histidine kinase
CIB87_06955	COG2204	response regulator
CIB87_06965	COG0477	Major facilitator Superfamily
CIB87_06985	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_07020	COG0517	IMP dehydrogenase activity
CIB87_07035	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CIB87_07040	COG1063	alcohol dehydrogenase
CIB87_07045	COG0800	Aldolase
CIB87_07050	COG1312	Catalyzes the dehydration of D-mannonate
CIB87_07055	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_07060	COG1609	Transcriptional regulator
CIB87_07065	COG2271	Major facilitator Superfamily
CIB87_07070	COG2207	Transcriptional regulator
CIB87_07070	COG3708	Transcriptional regulator
CIB87_07075	COG2721	sulfolactate sulfo-lyase activity
CIB87_07080	COG1063	alcohol dehydrogenase
CIB87_07085	COG0246	Mannitol dehydrogenase
CIB87_07095	COG1309	transcriptional regulator
CIB87_07100	COG1940	carbohydrate kinase activity
CIB87_07110	COG1070	Carbohydrate kinase
CIB87_07115	COG2814	Major facilitator Superfamily
CIB87_07115	COG0477	Major facilitator Superfamily
CIB87_07120	COG3290	protein histidine kinase activity
CIB87_07120	COG3829	transcription factor binding
CIB87_07125	COG2851	Citrate transporter
CIB87_07150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CIB87_07155	COG1845	cytochrome c oxidase, subunit III
CIB87_07165	COG0589	response to stress
CIB87_07170	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_07175	COG1612	heme a metabolic process
CIB87_07180	COG2072	flavoprotein involved in K transport
CIB87_07190	COG2252	PERMEase
CIB87_07195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CIB87_07200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CIB87_07205	COG0022	dehydrogenase e1 component
CIB87_07210	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIB87_07215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CIB87_07220	COG3284	Transcriptional regulator
CIB87_07230	COG1846	Transcriptional regulator
CIB87_07270	COG0628	permease
CIB87_07275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIB87_07285	COG2211	Major facilitator Superfamily
CIB87_07305	COG0589	response to stress
CIB87_07310	COG5002	protein histidine kinase activity
CIB87_07315	COG0745	RESPONSE REGULATOR receiver
CIB87_07320	COG1937	Protein conserved in bacteria
CIB87_07325	COG2608	mercury ion transmembrane transporter activity
CIB87_07330	COG2217	Heavy metal translocating P-type atpase
CIB87_07340	COG1388	LysM domain
CIB87_07345	COG2271	Major facilitator Superfamily
CIB87_07385	COG0640	Transcriptional regulator
CIB87_07390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CIB87_07400	COG2050	protein possibly involved in aromatic compounds catabolism
CIB87_07405	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CIB87_07410	COG2323	membrane
CIB87_07425	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CIB87_07430	COG0473	3-isopropylmalate dehydrogenase activity
CIB87_07435	COG2814	Major facilitator Superfamily
CIB87_07440	COG1733	regulation of RNA biosynthetic process
CIB87_07445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIB87_07445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIB87_07450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CIB87_07450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CIB87_07480	COG5566	PFAM Mor transcription activator
CIB87_07495	COG0561	phosphatase activity
CIB87_07500	COG1876	peptidase activity
CIB87_07505	COG0726	polysaccharide deacetylase
CIB87_07545	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CIB87_07560	COG0386	Belongs to the glutathione peroxidase family
CIB87_07565	COG1418	mRNA catabolic process
CIB87_07570	COG0488	(ABC) transporter
CIB87_07575	COG1413	lyase activity
CIB87_07580	COG0726	polysaccharide deacetylase
CIB87_07590	COG2136	Putative SAM-dependent methyltransferase
CIB87_07590	COG2521	methyltransferase
CIB87_07600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIB87_07605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIB87_07615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CIB87_07620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIB87_07625	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CIB87_07630	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CIB87_07635	COG0406	alpha-ribazole phosphatase activity
CIB87_07645	COG2096	Adenosyltransferase
CIB87_07650	COG2962	Rard protein
CIB87_07665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CIB87_07670	COG0322	excinuclease ABC activity
CIB87_07680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIB87_07685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CIB87_07690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CIB87_07700	COG3011	Protein conserved in bacteria
CIB87_07705	COG1595	DNA-templated transcription, initiation
CIB87_07725	COG2002	toxin-antitoxin pair type II binding
CIB87_07730	COG0534	Mate efflux family protein
CIB87_07735	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_07760	COG1368	sulfuric ester hydrolase activity
CIB87_07770	COG3853	Toxic anion resistance protein (TelA)
CIB87_07785	COG0726	polysaccharide deacetylase
CIB87_07795	COG2234	aminopeptidase activity
CIB87_07800	COG5002	protein histidine kinase activity
CIB87_07810	COG1823	symporter activity
CIB87_07815	COG1523	belongs to the glycosyl hydrolase 13 family
CIB87_07820	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_07825	COG2124	cytochrome p450
CIB87_07830	COG2112	serine threonine protein kinase
CIB87_07840	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CIB87_07845	COG1360	Flagellar Motor Protein
CIB87_07860	COG3361	conserved protein (COG2071)
CIB87_07865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIB87_07870	COG1757	Na H antiporter
CIB87_07880	COG0833	amino acid
CIB87_07885	COG3594	Acyltransferase
CIB87_07890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CIB87_07895	COG0745	RESPONSE REGULATOR receiver
CIB87_07900	COG5002	protein histidine kinase activity
CIB87_07905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CIB87_07910	COG3104	oligopeptide transport
CIB87_07920	COG0281	malic enzyme
CIB87_07925	COG3493	citrate carrier protein
CIB87_07930	COG0561	phosphatase activity
CIB87_07935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIB87_07950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CIB87_07955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CIB87_07960	COG0765	amino acid transport
CIB87_07965	COG0765	amino acid transport
CIB87_07970	COG1126	abc transporter atp-binding protein
CIB87_07975	COG0196	riboflavin kinase activity
CIB87_07980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIB87_07990	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIB87_08030	COG1611	Belongs to the LOG family
CIB87_08035	COG0281	malic enzyme
CIB87_08040	COG3402	PFAM membrane-flanked domain
CIB87_08045	COG3428	Bacterial PH domain
CIB87_08060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIB87_08065	COG0109	protoheme IX farnesyltransferase activity
CIB87_08070	COG4195	phage-related replication protein
CIB87_08080	COG0789	Transcriptional regulator
CIB87_08115	COG0583	DNA-binding transcription factor activity
CIB87_08120	COG0067	glutamate synthase
CIB87_08120	COG0069	glutamate synthase activity
CIB87_08120	COG0070	glutamate synthase
CIB87_08125	COG0493	'glutamate synthase
CIB87_08145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CIB87_08160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIB87_08175	COG1846	Transcriptional regulator
CIB87_08180	COG1380	Effector of murein hydrolase LrgA
CIB87_08185	COG1346	cytolysis
CIB87_08190	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_08205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CIB87_08210	COG0463	Glycosyl transferase, family 2
CIB87_08215	COG2246	polysaccharide biosynthetic process
CIB87_08220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CIB87_08225	COG0745	RESPONSE REGULATOR receiver
CIB87_08235	COG5583	Uncharacterized small protein (DUF2292)
CIB87_08245	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CIB87_08255	COG4208	sulfate ABC transporter
CIB87_08275	COG0745	RESPONSE REGULATOR receiver
CIB87_08300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_08310	COG1349	DNA-binding transcription factor activity
CIB87_08315	COG1105	Belongs to the carbohydrate kinase PfkB family
CIB87_08320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIB87_08320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CIB87_08320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CIB87_08325	COG0527	aspartate kinase activity
CIB87_08335	COG2032	superoxide dismutase activity
CIB87_08340	COG1233	COG1233 Phytoene dehydrogenase and related
CIB87_08350	COG0300	oxidoreductase activity
CIB87_08355	COG0640	Transcriptional regulator
CIB87_08360	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_08365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CIB87_08380	COG0733	neurotransmitter:sodium symporter activity
CIB87_08390	COG3773	Cell wall hydrolase
CIB87_08410	COG0673	inositol 2-dehydrogenase activity
CIB87_08415	COG1082	Xylose isomerase domain protein TIM barrel
CIB87_08420	COG2094	Belongs to the DNA glycosylase MPG family
CIB87_08430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CIB87_08440	COG0454	-acetyltransferase
CIB87_08450	COG2814	Major facilitator Superfamily
CIB87_08465	COG3871	stress protein (general stress protein 26)
CIB87_08490	COG1595	DNA-templated transcription, initiation
CIB87_08495	COG4873	Protein conserved in bacteria
CIB87_08500	COG0714	Associated with various cellular activities
CIB87_08505	COG4548	von Willebrand factor, type A
CIB87_08510	COG0697	spore germination
CIB87_08520	COG2207	Transcriptional regulator
CIB87_08525	COG1994	Peptidase M50
CIB87_08530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIB87_08535	COG1119	ATPase activity
CIB87_08550	COG1657	PFAM Prenyltransferase squalene oxidase
CIB87_08560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CIB87_08560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CIB87_08570	COG0384	phenazine biosynthesis protein PhzF
CIB87_08585	COG1378	Sugar-specific transcriptional regulator TrmB
CIB87_08590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIB87_08615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIB87_08620	COG1279	arginine transmembrane transporter activity
CIB87_08650	COG3541	Predicted nucleotidyltransferase
CIB87_08670	COG1396	sequence-specific DNA binding
CIB87_08685	COG0494	nUDIX hydrolase
CIB87_08690	COG1335	isochorismatase
CIB87_08695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CIB87_08700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CIB87_08705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CIB87_08710	COG1098	S1 RNA binding domain
CIB87_08715	COG1404	Belongs to the peptidase S8 family
CIB87_08725	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_08730	COG1254	Belongs to the acylphosphatase family
CIB87_08735	COG2223	nitrite transmembrane transporter activity
CIB87_08740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIB87_08750	COG2207	Transcriptional regulator
CIB87_08750	COG0662	Cupin 2, conserved barrel domain protein
CIB87_08755	COG0697	spore germination
CIB87_08760	COG0488	(ABC) transporter
CIB87_08770	COG0697	spore germination
CIB87_08775	COG0531	amino acid
CIB87_08790	COG1131	(ABC) transporter
CIB87_08795	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CIB87_08800	COG1757	Na H antiporter
CIB87_08805	COG1609	Transcriptional regulator
CIB87_08815	COG1533	DNA photolyase activity
CIB87_08835	COG0551	DNA topoisomerase type I activity
CIB87_08835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIB87_08850	COG0446	pyridine nucleotide-disulphide oxidoreductase
CIB87_08870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIB87_08890	COG1757	Na H antiporter
CIB87_08905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIB87_08915	COG2720	vancomycin resistance protein
CIB87_08980	COG1215	transferase activity, transferring glycosyl groups
CIB87_09010	COG0514	ATP-dependent DNA helicase (RecQ)
CIB87_09040	COG1575	Belongs to the MenA family. Type 1 subfamily
CIB87_09060	COG2814	Major facilitator Superfamily
CIB87_09065	COG0583	DNA-binding transcription factor activity
CIB87_09070	COG1725	Transcriptional regulator
CIB87_09075	COG1131	(ABC) transporter
CIB87_09085	COG1595	DNA-templated transcription, initiation
CIB87_09100	COG1764	response to oxidative stress
CIB87_09105	COG1846	Transcriptional regulator
CIB87_09120	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CIB87_09130	COG3584	3D domain protein
CIB87_09130	COG1388	LysM domain
CIB87_09150	COG5002	protein histidine kinase activity
CIB87_09155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CIB87_09160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CIB87_09165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CIB87_09180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CIB87_09195	COG2409	Drug exporters of the RND superfamily
CIB87_09200	COG1834	amidinotransferase
CIB87_09210	COG1295	ribonuclease BN
CIB87_09260	COG0346	lactoylglutathione lyase activity
CIB87_09270	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_09280	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CIB87_09290	COG2176	DNA-directed DNA polymerase activity
CIB87_09305	COG0114	fumarate hydratase activity
CIB87_09315	COG3409	Peptidoglycan-binding domain 1 protein
CIB87_09315	COG3757	hydrolase, family 25
CIB87_09325	COG5002	protein histidine kinase activity
CIB87_09365	COG0778	Nitroreductase
CIB87_09375	COG0300	oxidoreductase activity
CIB87_09380	COG3290	protein histidine kinase activity
CIB87_09385	COG4565	transcriptional regulatory protein
CIB87_09390	COG2851	Citrate transporter
CIB87_09400	COG2610	gluconate transmembrane transporter activity
CIB87_09405	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_09410	COG2195	Cleaves the N-terminal amino acid of tripeptides
CIB87_09440	COG0583	DNA-binding transcription factor activity
CIB87_09455	COG1301	dicarboxylic acid transport
CIB87_09460	COG0019	diaminopimelate decarboxylase activity
CIB87_09470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIB87_09480	COG4191	Histidine kinase
CIB87_09495	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_09500	COG0318	PFAM AMP-dependent synthetase and ligase
CIB87_09510	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIB87_09515	COG1024	Enoyl-CoA hydratase
CIB87_09530	COG2045	Belongs to the ComB family
CIB87_09535	COG1960	acyl-CoA dehydrogenase activity
CIB87_09540	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_09545	COG1024	Enoyl-CoA hydratase
CIB87_09560	COG1141	Ferredoxin
CIB87_09570	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CIB87_09575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CIB87_09580	COG0183	Belongs to the thiolase family
CIB87_09585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CIB87_09610	COG1509	lysine 2,3-aminomutase activity
CIB87_09620	COG0833	amino acid
CIB87_09635	COG0456	acetyltransferase
CIB87_09640	COG1979	alcohol dehydrogenase
CIB87_09645	COG0738	Major facilitator superfamily
CIB87_09655	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIB87_09675	COG3977	Valine--pyruvate aminotransferase
CIB87_09685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CIB87_09690	COG3773	Cell wall hydrolase
CIB87_09700	COG3119	arylsulfatase activity
CIB87_09705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CIB87_09715	COG0531	amino acid
CIB87_09720	COG2814	Major facilitator Superfamily
CIB87_09725	COG1846	Transcriptional regulator
CIB87_09730	COG2409	Drug exporters of the RND superfamily
CIB87_09730	COG1033	growth of symbiont in host cell
CIB87_09740	COG2222	sugar isomerase
CIB87_09745	COG1653	transport
CIB87_09750	COG1175	transmembrane transport
CIB87_09755	COG0395	ABC-type sugar transport system, permease component
CIB87_09760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIB87_09765	COG2188	Transcriptional regulator
CIB87_09770	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_09770	COG2202	Pas domain
CIB87_09775	COG3832	glyoxalase III activity
CIB87_09780	COG0640	Transcriptional regulator
CIB87_09790	COG2267	carboxylic ester hydrolase activity
CIB87_09800	COG3386	PFAM SMP-30 Gluconolaconase
CIB87_09810	COG2368	4-hydroxyphenylacetate
CIB87_09815	COG3739	integral membrane protein
CIB87_09830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CIB87_09860	COG0730	response to heat
CIB87_09875	COG0456	acetyltransferase
CIB87_09880	COG2318	DinB family
CIB87_09890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIB87_09900	COG1819	glycosyl
CIB87_09915	COG0138	bifunctional purine biosynthesis protein purh
CIB87_09920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CIB87_09925	COG2226	methyltransferase
CIB87_09930	COG0662	Cupin 2, conserved barrel domain protein
CIB87_09940	COG1733	regulation of RNA biosynthetic process
CIB87_10000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIB87_10005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIB87_10015	COG2851	Citrate transporter
CIB87_10030	COG0372	Belongs to the citrate synthase family
CIB87_10040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CIB87_10045	COG1024	Enoyl-CoA hydratase
CIB87_10050	COG1024	Enoyl-CoA hydratase
CIB87_10055	COG1024	Enoyl-CoA hydratase
CIB87_10060	COG0183	Belongs to the thiolase family
CIB87_10065	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIB87_10070	COG2851	Citrate transporter
CIB87_10075	COG1609	Transcriptional regulator
CIB87_10080	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_10085	COG1082	Xylose isomerase domain protein TIM barrel
CIB87_10090	COG2814	Major facilitator Superfamily
CIB87_10145	COG0456	acetyltransferase
CIB87_10145	COG1846	Transcriptional regulator
CIB87_10150	COG2851	Citrate transporter
CIB87_10160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CIB87_10170	COG3964	amidohydrolase
CIB87_10190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CIB87_10215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CIB87_10220	COG3757	hydrolase, family 25
CIB87_10220	COG3409	Peptidoglycan-binding domain 1 protein
CIB87_10230	COG0697	spore germination
CIB87_10235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIB87_10250	COG4572	Cation transport regulator
CIB87_10255	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CIB87_10260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CIB87_10275	COG3011	Protein conserved in bacteria
CIB87_10280	COG1136	(ABC) transporter
CIB87_10330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIB87_10350	COG0702	epimerase
CIB87_10355	COG0318	PFAM AMP-dependent synthetase and ligase
CIB87_10360	COG1846	Transcriptional regulator
CIB87_10365	COG2720	vancomycin resistance protein
CIB87_10370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CIB87_10395	COG0076	glutamate decarboxylase activity
CIB87_10420	COG2116	formate transmembrane transporter activity
CIB87_10425	COG5609	conserved protein (DUF2294)
CIB87_10440	COG2271	Major facilitator Superfamily
CIB87_10445	COG0277	FAD linked oxidase domain protein
CIB87_10450	COG0840	transmembrane signaling receptor activity
CIB87_10460	COG0622	Phosphoesterase
CIB87_10470	COG1408	metallophosphoesterase
CIB87_10475	COG3663	DNA glycosylase
CIB87_10480	COG0791	NLP P60 protein
CIB87_10480	COG3883	PFAM NLP P60 protein
CIB87_10485	COG1587	Uroporphyrinogen-III synthase
CIB87_10490	COG1414	Transcriptional regulator
CIB87_10495	COG0439	Biotin carboxylase
CIB87_10500	COG0511	ligase activity, forming carbon-carbon bonds
CIB87_10505	COG1984	allophanate hydrolase subunit 2
CIB87_10510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CIB87_10515	COG4336	lyase activity
CIB87_10520	COG1914	H( )-stimulated, divalent metal cation uptake system
CIB87_10525	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CIB87_10570	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIB87_10580	COG3409	Peptidoglycan-binding domain 1 protein
CIB87_10580	COG3757	hydrolase, family 25
CIB87_10655	COG0739	heme binding
CIB87_10655	COG1196	nuclear chromosome segregation
CIB87_10655	COG0741	lytic transglycosylase activity
CIB87_10740	COG5484	DNA packaging
CIB87_10740	COG3728	DNA packaging
CIB87_10785	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CIB87_10800	COG0305	Participates in initiation and elongation during chromosome replication
CIB87_10810	COG3935	DnaD domain protein
CIB87_10815	COG3723	Recombinational DNA repair protein, rece pathway
CIB87_10820	COG5377	YqaJ viral recombinase family
CIB87_10855	COG1396	sequence-specific DNA binding
CIB87_10880	COG0582	viral genome integration into host DNA
CIB87_10895	COG0110	maltose O-acetyltransferase activity
CIB87_10915	COG0531	amino acid
CIB87_10920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CIB87_10925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIB87_10940	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CIB87_10945	COG4844	belongs to the
CIB87_10955	COG0583	DNA-binding transcription factor activity
CIB87_10970	COG0346	lactoylglutathione lyase activity
CIB87_10990	COG0110	maltose O-acetyltransferase activity
CIB87_10995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIB87_11010	COG0395	ABC-type sugar transport system, permease component
CIB87_11015	COG1175	transmembrane transport
CIB87_11025	COG1609	Transcriptional regulator
CIB87_11030	COG2030	dehydratase
CIB87_11035	COG2814	Major facilitator Superfamily
CIB87_11040	COG1082	Xylose isomerase domain protein TIM barrel
CIB87_11045	COG0673	inositol 2-dehydrogenase activity
CIB87_11050	COG1609	Transcriptional regulator
CIB87_11055	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CIB87_11065	COG0318	PFAM AMP-dependent synthetase and ligase
CIB87_11070	COG1268	BioY protein
CIB87_11075	COG0183	Belongs to the thiolase family
CIB87_11095	COG0431	NADPH-dependent FMN reductase
CIB87_11100	COG2197	response regulator
CIB87_11105	COG4585	Histidine kinase
CIB87_11105	COG2203	Gaf domain
CIB87_11125	COG0697	spore germination
CIB87_11135	COG2153	protein acetylation
CIB87_11140	COG0129	dihydroxy-acid dehydratase activity
CIB87_11145	COG2267	carboxylic ester hydrolase activity
CIB87_11150	COG1227	inorganic diphosphatase activity
CIB87_11165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CIB87_11175	COG0204	Acyl-transferase
CIB87_11180	COG2233	PERMEase
CIB87_11185	COG3195	allantoin biosynthetic process
CIB87_11185	COG3648	Uricase
CIB87_11195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIB87_11210	COG1914	H( )-stimulated, divalent metal cation uptake system
CIB87_11230	COG1846	Transcriptional regulator
CIB87_11240	COG4974	Belongs to the 'phage' integrase family
CIB87_11260	COG0531	amino acid
CIB87_11265	COG4302	ethanolamine ammonia-lyase activity
CIB87_11270	COG4303	Ethanolamine ammonia lyase large subunit
CIB87_11275	COG4819	ethanolamine utilization protein
CIB87_11285	COG0833	amino acid
CIB87_11295	COG1247	-acetyltransferase
CIB87_11300	COG1335	isochorismatase
CIB87_11310	COG3403	YqcI/YcgG family
CIB87_11315	COG1280	lysine exporter protein (LysE YggA)
CIB87_11320	COG2267	carboxylic ester hydrolase activity
CIB87_11330	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CIB87_11335	COG0187	DNA topoisomerase II activity
CIB87_11340	COG1832	CoA-binding protein
CIB87_11345	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CIB87_11350	COG4841	protein insertion into membrane
CIB87_11355	COG0824	Thioesterase
CIB87_11390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CIB87_11410	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CIB87_11445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CIB87_11450	COG2068	MobA-Related Protein
CIB87_11455	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CIB87_11510	COG1183	phosphatidylcholine synthase activity
CIB87_11525	COG2814	Major facilitator Superfamily
CIB87_11530	COG1683	Conserved Protein
CIB87_11535	COG1302	Protein conserved in bacteria
CIB87_11550	COG1295	ribonuclease BN
CIB87_11560	COG1115	amino acid carrier protein
CIB87_11565	COG2814	Major facilitator Superfamily
CIB87_11575	COG2814	Major facilitator Superfamily
CIB87_11580	COG0789	Transcriptional regulator
CIB87_11590	COG0288	reversible hydration of carbon dioxide
CIB87_11595	COG0659	secondary active sulfate transmembrane transporter activity
CIB87_11600	COG0745	RESPONSE REGULATOR receiver
CIB87_11605	COG5002	protein histidine kinase activity
CIB87_11615	COG4282	regulation of fungal-type cell wall biogenesis
CIB87_11620	COG0531	amino acid
CIB87_11630	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIB87_11635	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CIB87_11705	COG1363	Peptidase, m42
CIB87_11715	COG1114	Component of the transport system for branched-chain amino acids
CIB87_11735	COG0004	ammonium transporteR
CIB87_11750	COG1252	NADH dehydrogenase
CIB87_11755	COG0679	Auxin Efflux Carrier
CIB87_11760	COG0281	malic enzyme
CIB87_11780	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CIB87_11785	COG0163	prenyltransferase activity
CIB87_11790	COG0583	DNA-binding transcription factor activity
CIB87_11795	COG0679	Auxin Efflux Carrier
CIB87_11815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIB87_11820	COG0247	lactate metabolic process
CIB87_11825	COG0277	FAD linked oxidase domain protein
CIB87_11830	COG3835	regulator
CIB87_11835	COG0693	protein deglycase activity
CIB87_11845	COG2610	gluconate transmembrane transporter activity
CIB87_11865	COG1131	(ABC) transporter
CIB87_11875	COG2197	response regulator
CIB87_11910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIB87_11920	COG0586	Pfam SNARE associated Golgi protein
CIB87_11925	COG1515	deoxyribonuclease V activity
CIB87_11930	COG0584	glycerophosphoryl diester phosphodiesterase
CIB87_11935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIB87_11945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIB87_11950	COG0531	amino acid
CIB87_12035	COG0534	Mate efflux family protein
CIB87_12040	COG1566	PFAM secretion protein HlyD family protein
CIB87_12050	COG1846	Transcriptional regulator
CIB87_12055	COG0708	Exodeoxyribonuclease III
CIB87_12070	COG0673	inositol 2-dehydrogenase activity
CIB87_12075	COG1349	DNA-binding transcription factor activity
CIB87_12080	COG3853	Toxic anion resistance protein (TelA)
CIB87_12090	COG2310	stress, protein
CIB87_12095	COG2310	stress, protein
CIB87_12100	COG2310	stress, protein
CIB87_12105	COG0737	Belongs to the 5'-nucleotidase family
CIB87_12120	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CIB87_12125	COG1131	(ABC) transporter
CIB87_12135	COG2084	Dehydrogenase
CIB87_12140	COG1278	Cold shock
CIB87_12145	COG1368	sulfuric ester hydrolase activity
CIB87_12150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIB87_12155	COG0028	Belongs to the TPP enzyme family
CIB87_12160	COG1278	Cold shock
CIB87_12185	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_12200	COG0427	acetyl-CoA hydrolase
CIB87_12205	COG3279	Response regulator of the LytR AlgR family
CIB87_12210	COG2323	membrane
CIB87_12215	COG2814	Major facilitator Superfamily
CIB87_12220	COG1388	LysM domain
CIB87_12220	COG3584	3D domain protein
CIB87_12225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CIB87_12250	COG3340	Belongs to the peptidase S51 family
CIB87_12265	COG0277	FAD linked oxidase domain protein
CIB87_12355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CIB87_12380	COG2318	DinB family
CIB87_12390	COG0579	oxidoreductase
CIB87_12420	COG5444	nuclease activity
CIB87_12445	COG1486	melibiose metabolic process
CIB87_12480	COG1929	Belongs to the glycerate kinase type-1 family
CIB87_12485	COG2610	gluconate transmembrane transporter activity
CIB87_12490	COG3835	regulator
CIB87_12495	COG1454	alcohol dehydrogenase
CIB87_12500	COG3152	Membrane
CIB87_12525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CIB87_12530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIB87_12535	COG3152	Membrane
CIB87_12540	COG3152	Membrane
CIB87_12560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CIB87_12565	COG0295	cytidine deaminase activity
CIB87_12570	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CIB87_12585	COG2390	Transcriptional regulator
CIB87_12615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CIB87_12620	COG0501	Belongs to the peptidase M48B family
CIB87_12625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIB87_12630	COG1742	UPF0060 membrane protein
CIB87_12635	COG2182	Extracellular solute-binding protein
CIB87_12655	COG2031	fatty acid transporter
CIB87_12685	COG2391	methyltransferase activity
CIB87_12700	COG1979	alcohol dehydrogenase
CIB87_12705	COG0583	DNA-binding transcription factor activity
CIB87_12725	COG2211	Major facilitator Superfamily
CIB87_12755	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_12760	COG1063	alcohol dehydrogenase
CIB87_12795	COG0025	NhaP-type Na H and K H
CIB87_12800	COG1253	flavin adenine dinucleotide binding
CIB87_12825	COG4608	Belongs to the ABC transporter superfamily
CIB87_12835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CIB87_12840	COG0601	transmembrane transport
CIB87_12845	COG0747	negative chemotaxis
CIB87_12855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_12885	COG0579	oxidoreductase
CIB87_12890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CIB87_12895	COG0561	phosphatase activity
CIB87_12910	COG0668	transmembrane transport
CIB87_12935	COG2309	aminopeptidase activity
CIB87_12945	COG2309	aminopeptidase activity
CIB87_12950	COG1414	Transcriptional regulator
CIB87_12955	COG0179	Fumarylacetoacetate (FAA) hydrolase
CIB87_12960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CIB87_12965	COG0277	FAD linked oxidase domain protein
CIB87_12970	COG0247	lactate metabolic process
CIB87_12975	COG0277	FAD linked oxidase domain protein
CIB87_12980	COG1620	l-lactate permease
CIB87_13000	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CIB87_13005	COG1131	(ABC) transporter
CIB87_13025	COG1595	DNA-templated transcription, initiation
CIB87_13045	COG4682	membrane
CIB87_13060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIB87_13065	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_13070	COG0598	Magnesium transport protein CorA
CIB87_13075	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CIB87_13085	COG2323	membrane
CIB87_13090	COG1876	peptidase activity
CIB87_13100	COG5002	protein histidine kinase activity
CIB87_13105	COG0745	RESPONSE REGULATOR receiver
CIB87_13130	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIB87_13135	COG0567	Dehydrogenase, E1 component
CIB87_13145	COG2814	Major facilitator Superfamily
CIB87_13150	COG1764	response to oxidative stress
CIB87_13160	COG2311	Membrane
CIB87_13200	COG0347	Belongs to the P(II) protein family
CIB87_13205	COG0004	ammonium transporteR
CIB87_13210	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CIB87_13225	COG0596	Alpha beta hydrolase
CIB87_13240	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CIB87_13240	COG0456	acetyltransferase
CIB87_13245	COG1960	acyl-CoA dehydrogenase activity
CIB87_13285	COG4604	ABC transporter, ATP-binding protein
CIB87_13290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIB87_13295	COG1492	cobalamin metabolic process
CIB87_13305	COG0531	amino acid
CIB87_13315	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_13320	COG2404	hydrolase activity, acting on ester bonds
CIB87_13325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CIB87_13335	COG1609	Transcriptional regulator
CIB87_13345	COG2271	Major facilitator Superfamily
CIB87_13350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIB87_13365	COG1233	COG1233 Phytoene dehydrogenase and related
CIB87_13370	COG1215	transferase activity, transferring glycosyl groups
CIB87_13425	COG0831	urea catabolic process
CIB87_13430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CIB87_13435	COG1388	LysM domain
CIB87_13435	COG0791	NLP P60 protein
CIB87_13440	COG3584	3D domain protein
CIB87_13440	COG1388	LysM domain
CIB87_13445	COG0778	Nitroreductase
CIB87_13450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CIB87_13455	COG0586	Pfam SNARE associated Golgi protein
CIB87_13465	COG0400	carboxylic ester hydrolase activity
CIB87_13470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIB87_13475	COG2244	polysaccharide biosynthetic process
CIB87_13480	COG0697	spore germination
CIB87_13485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIB87_13505	COG1132	(ABC) transporter
CIB87_13530	COG4195	phage-related replication protein
CIB87_13540	COG0783	Belongs to the Dps family
CIB87_13550	COG5577	PFAM Coat F domain
CIB87_13555	COG1253	flavin adenine dinucleotide binding
CIB87_13570	COG0517	IMP dehydrogenase activity
CIB87_13570	COG0516	GMP reductase activity
CIB87_13580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIB87_13580	COG0723	plastoquinol--plastocyanin reductase activity
CIB87_13595	COG0287	Prephenate dehydrogenase
CIB87_13605	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CIB87_13605	COG1605	Chorismate mutase
CIB87_13615	COG2059	Chromate
CIB87_13620	COG2059	Chromate
CIB87_13630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CIB87_13635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CIB87_13640	COG2508	Transcriptional regulator
CIB87_13645	COG0011	TIGRFAM Protein of
CIB87_13650	COG0791	NLP P60 protein
CIB87_13650	COG1388	LysM domain
CIB87_13655	COG0753	catalase activity
CIB87_13665	COG0733	neurotransmitter:sodium symporter activity
CIB87_13705	COG0730	response to heat
CIB87_13710	COG1902	pentaerythritol trinitrate reductase activity
CIB87_13725	COG2205	protein histidine kinase activity
CIB87_13760	COG0640	Transcriptional regulator
CIB87_13770	COG0778	Nitroreductase
CIB87_13785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CIB87_13790	COG4991	sh3 domain protein
CIB87_13790	COG3103	Sh3 type 3 domain protein
CIB87_13790	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIB87_13795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CIB87_13800	COG2002	toxin-antitoxin pair type II binding
CIB87_13805	COG2318	DinB family
CIB87_13810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CIB87_13820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CIB87_13825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_13840	COG2211	Major facilitator Superfamily
CIB87_13845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_13850	COG1597	lipid kinase activity
CIB87_13860	COG0372	Belongs to the citrate synthase family
CIB87_13865	COG0583	DNA-binding transcription factor activity
CIB87_13885	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_13885	COG2202	Pas domain
CIB87_13890	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_13920	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_13925	COG2261	transglycosylase associated protein
CIB87_13935	COG0740	serine-type endopeptidase activity
CIB87_13950	COG1027	Aspartate ammonia-lyase
CIB87_13955	COG0252	asparaginase activity
CIB87_13960	COG1396	sequence-specific DNA binding
CIB87_13975	COG0640	Transcriptional regulator
CIB87_13995	COG0531	amino acid
CIB87_14000	COG1959	2 iron, 2 sulfur cluster binding
CIB87_14020	COG0281	malic enzyme
CIB87_14025	COG2746	aminoglycoside 3-N-acetyltransferase activity
CIB87_14035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIB87_14040	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_14050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CIB87_14055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CIB87_14065	COG0477	Major facilitator Superfamily
CIB87_14070	COG1846	Transcriptional regulator
CIB87_14075	COG0789	Transcriptional regulator
CIB87_14080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIB87_14115	COG1819	glycosyl
CIB87_14135	COG1902	pentaerythritol trinitrate reductase activity
CIB87_14145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIB87_14160	COG2814	Major facilitator Superfamily
CIB87_14170	COG1228	amidohydrolase
CIB87_14180	COG1316	TRANSCRIPTIONal
CIB87_14185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIB87_14205	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CIB87_14215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CIB87_14220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CIB87_14270	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIB87_14280	COG1280	lysine exporter protein (LysE YggA)
CIB87_14285	COG0531	amino acid
CIB87_14300	COG3764	Sortase (surface protein transpeptidase)
CIB87_14305	COG0730	response to heat
CIB87_14310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIB87_14315	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CIB87_14325	COG2130	NADP-dependent
CIB87_14345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_14360	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CIB87_14365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CIB87_14370	COG0501	Belongs to the peptidase M48B family
CIB87_14415	COG1309	transcriptional regulator
CIB87_14420	COG2076	Multidrug Resistance protein
CIB87_14425	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CIB87_14430	COG1278	Cold shock
CIB87_14435	COG2323	membrane
CIB87_14445	COG2910	NAD(P)H-binding
CIB87_14475	COG4607	ABC-type enterochelin transport system periplasmic component
CIB87_14480	COG4604	ABC transporter, ATP-binding protein
CIB87_14485	COG4605	iron ion homeostasis
CIB87_14490	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIB87_14495	COG3773	Cell wall hydrolase
CIB87_14515	COG1063	alcohol dehydrogenase
CIB87_14520	COG3775	system Galactitol-specific IIC component
CIB87_14525	COG3414	Phosphotransferase system galactitol-specific IIB component
CIB87_14530	COG3414	Phosphotransferase system galactitol-specific IIB component
CIB87_14545	COG2249	NAD(P)H dehydrogenase (quinone) activity
CIB87_14550	COG0681	Belongs to the peptidase S26 family
CIB87_14575	COG1193	negative regulation of DNA recombination
CIB87_14585	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CIB87_14590	COG1396	sequence-specific DNA binding
CIB87_14595	COG0861	Integral membrane protein TerC family
CIB87_14600	COG1609	Transcriptional regulator
CIB87_14605	COG1959	2 iron, 2 sulfur cluster binding
CIB87_14665	COG3773	Cell wall hydrolase
CIB87_14670	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CIB87_14695	COG3546	catalase activity
CIB87_14715	COG1280	lysine exporter protein (LysE YggA)
CIB87_14720	COG2207	Transcriptional regulator
CIB87_14720	COG1917	Cupin 2, conserved barrel domain protein
CIB87_14725	COG4585	Histidine kinase
CIB87_14735	COG0584	glycerophosphoryl diester phosphodiesterase
CIB87_14750	COG3209	COG3209 Rhs family protein
CIB87_14775	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CIB87_14785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CIB87_14810	COG0346	lactoylglutathione lyase activity
CIB87_14815	COG1136	(ABC) transporter
CIB87_14820	COG0577	efflux transmembrane transporter activity
CIB87_14825	COG5002	protein histidine kinase activity
CIB87_14825	COG3850	Histidine kinase
CIB87_14835	COG0384	phenazine biosynthesis protein PhzF
CIB87_14850	COG5002	protein histidine kinase activity
CIB87_14855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIB87_14880	COG4989	oxidoreductase activity
CIB87_14895	COG1917	Cupin 2, conserved barrel domain protein
CIB87_14895	COG2207	Transcriptional regulator
CIB87_14970	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CIB87_14980	COG0583	DNA-binding transcription factor activity
CIB87_14990	COG1301	dicarboxylic acid transport
CIB87_14995	COG2824	Alkylphosphonate utilization operon protein PhnA
CIB87_15030	COG1073	alpha beta
CIB87_15055	COG0745	RESPONSE REGULATOR receiver
CIB87_15060	COG2205	protein histidine kinase activity
CIB87_15065	COG1136	(ABC) transporter
CIB87_15070	COG0577	efflux transmembrane transporter activity
CIB87_15080	COG0412	Dienelactone hydrolase
CIB87_15085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIB87_15100	COG0730	response to heat
CIB87_15105	COG0425	Belongs to the sulfur carrier protein TusA family
CIB87_15110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIB87_15110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIB87_15115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIB87_15115	COG0425	Belongs to the sulfur carrier protein TusA family
CIB87_15120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIB87_15130	COG2210	Belongs to the sulfur carrier protein TusA family
CIB87_15135	COG0425	Belongs to the sulfur carrier protein TusA family
CIB87_15140	COG1937	Protein conserved in bacteria
CIB87_15170	COG0583	DNA-binding transcription factor activity
CIB87_15190	COG2188	Transcriptional regulator
CIB87_15200	COG2723	6-phospho-beta-galactosidase activity
CIB87_15225	COG1280	lysine exporter protein (LysE YggA)
CIB87_15230	COG3695	enzyme binding
CIB87_15240	COG0583	DNA-binding transcription factor activity
CIB87_15245	COG0346	lactoylglutathione lyase activity
CIB87_15260	COG3706	GGDEF domain
CIB87_15265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CIB87_15280	COG0778	Nitroreductase
CIB87_15285	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_15305	COG1704	LemA family
CIB87_15325	COG1733	regulation of RNA biosynthetic process
CIB87_15330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIB87_15335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIB87_15340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIB87_15355	COG2304	oxidoreductase activity
CIB87_15365	COG0346	lactoylglutathione lyase activity
CIB87_15370	COG2808	Putative FMN-binding domain
CIB87_15385	COG0596	Alpha beta hydrolase
CIB87_15400	COG4807	Protein conserved in bacteria
CIB87_15410	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CIB87_15420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_15425	COG1278	Cold shock
CIB87_15430	COG1278	Cold shock
CIB87_15435	COG0477	Major facilitator Superfamily
CIB87_15440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CIB87_15450	COG0477	Major facilitator Superfamily
CIB87_15495	COG0659	secondary active sulfate transmembrane transporter activity
CIB87_15570	COG4451	ribulose bisphosphate carboxylase, small
CIB87_15570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CIB87_15580	COG0561	phosphatase activity
CIB87_15590	COG2312	Erythromycin esterase
CIB87_15605	COG2329	Antibiotic biosynthesis monooxygenase
CIB87_15625	COG5002	protein histidine kinase activity
CIB87_15630	COG0745	RESPONSE REGULATOR receiver
CIB87_15645	COG1131	(ABC) transporter
CIB87_15680	COG3655	Transcriptional regulator
CIB87_15690	COG0589	response to stress
CIB87_15695	COG0659	secondary active sulfate transmembrane transporter activity
CIB87_15710	COG2323	membrane
CIB87_15730	COG0583	DNA-binding transcription factor activity
CIB87_15735	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_15745	COG1082	Xylose isomerase domain protein TIM barrel
CIB87_15750	COG1917	Cupin 2, conserved barrel domain protein
CIB87_15750	COG4977	sequence-specific DNA binding
CIB87_15760	COG1609	Transcriptional regulator
CIB87_15765	COG1082	Xylose isomerase domain protein TIM barrel
CIB87_15770	COG0673	inositol 2-dehydrogenase activity
CIB87_15790	COG3718	enzyme involved in inositol metabolism
CIB87_15795	COG3962	Belongs to the TPP enzyme family
CIB87_15800	COG1349	DNA-binding transcription factor activity
CIB87_15805	COG0191	fructose-bisphosphate aldolase activity
CIB87_15810	COG1082	Xylose isomerase domain protein TIM barrel
CIB87_15815	COG2814	Major facilitator Superfamily
CIB87_15830	COG1064	alcohol dehydrogenase
CIB87_15835	COG0789	Transcriptional regulator
CIB87_15850	COG0662	Cupin 2, conserved barrel domain protein
CIB87_15870	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_15875	COG1278	Cold shock
CIB87_15885	COG0840	transmembrane signaling receptor activity
CIB87_15895	COG1876	peptidase activity
CIB87_15915	COG0598	Magnesium transport protein CorA
CIB87_15920	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_15930	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_15940	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_15960	COG4335	DNA alkylation repair
CIB87_15965	COG0454	-acetyltransferase
CIB87_15975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CIB87_15995	COG2186	Transcriptional regulator
CIB87_16015	COG3619	membrane
CIB87_16020	COG1349	DNA-binding transcription factor activity
CIB87_16025	COG0561	phosphatase activity
CIB87_16035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CIB87_16065	COG1280	lysine exporter protein (LysE YggA)
CIB87_16095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CIB87_16120	COG2160	L-arabinose isomerase activity
CIB87_16135	COG1609	Transcriptional regulator
CIB87_16150	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CIB87_16155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CIB87_16160	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CIB87_16160	COG1918	ferrous iron import across plasma membrane
CIB87_16185	COG1846	Transcriptional regulator
CIB87_16220	COG0697	spore germination
CIB87_16225	COG0791	NLP P60 protein
CIB87_16225	COG1388	LysM domain
CIB87_16230	COG2258	MOSC domain
CIB87_16240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CIB87_16275	COG4974	Belongs to the 'phage' integrase family
CIB87_16305	COG1309	transcriptional regulator
CIB87_16310	COG3844	kynureninase activity
CIB87_16315	COG1113	amino acid transport
CIB87_16320	COG3483	tryptophan 2,3-dioxygenase activity
CIB87_16325	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CIB87_16330	COG1942	4-Oxalocrotonate Tautomerase
CIB87_16360	COG0251	oxidation-reduction process
CIB87_16375	COG0431	NADPH-dependent FMN reductase
CIB87_16380	COG0196	riboflavin kinase activity
CIB87_16385	COG2368	4-hydroxyphenylacetate
CIB87_16405	COG0789	Transcriptional regulator
CIB87_16445	COG5646	InterPro IPR014922
CIB87_16450	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CIB87_16510	COG2814	Major facilitator Superfamily
CIB87_16525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CIB87_16540	COG2323	membrane
CIB87_16545	COG2267	carboxylic ester hydrolase activity
CIB87_16550	COG1078	dGTPase activity
CIB87_16555	COG1694	Mazg nucleotide pyrophosphohydrolase
CIB87_16575	COG1113	amino acid transport
CIB87_16580	COG0506	proline dehydrogenase activity
CIB87_16585	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_16600	COG1994	Peptidase M50
CIB87_16605	COG2261	transglycosylase associated protein
CIB87_16630	COG1278	Cold shock
CIB87_16640	COG2814	Major facilitator Superfamily
CIB87_16645	COG1819	glycosyl
CIB87_16660	COG1388	LysM domain
CIB87_16715	COG2311	Membrane
CIB87_16740	COG1942	4-Oxalocrotonate Tautomerase
CIB87_16745	COG0583	DNA-binding transcription factor activity
CIB87_16780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIB87_16790	COG2267	carboxylic ester hydrolase activity
CIB87_16800	COG1335	isochorismatase
CIB87_16810	COG0346	lactoylglutathione lyase activity
CIB87_16815	COG2259	Doxx family
CIB87_16825	COG1819	glycosyl
CIB87_16835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CIB87_16840	COG2323	membrane
CIB87_16845	COG2323	membrane
CIB87_16865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CIB87_16890	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_16905	COG1501	Belongs to the glycosyl hydrolase 31 family
CIB87_16910	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CIB87_16920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CIB87_16925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CIB87_16950	COG0697	spore germination
CIB87_16960	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CIB87_16970	COG0477	Major facilitator Superfamily
CIB87_16980	COG0477	Major facilitator Superfamily
CIB87_16985	COG1309	transcriptional regulator
CIB87_17005	COG0156	8-amino-7-oxononanoate synthase activity
CIB87_17010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIB87_17020	COG1378	Sugar-specific transcriptional regulator TrmB
CIB87_17025	COG0697	spore germination
CIB87_17035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIB87_17040	COG2211	Major facilitator Superfamily
CIB87_17045	COG1063	alcohol dehydrogenase
CIB87_17050	COG0457	Tetratricopeptide repeat
CIB87_17080	COG1266	CAAX protease self-immunity
CIB87_17090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_17095	COG5577	PFAM Coat F domain
CIB87_17110	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_17120	COG0252	asparaginase activity
CIB87_17140	COG1695	Transcriptional regulator
CIB87_17150	COG0656	L-ascorbic acid biosynthetic process
CIB87_17160	COG0583	DNA-binding transcription factor activity
CIB87_17170	COG2814	Major facilitator Superfamily
CIB87_17175	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_17190	COG1309	transcriptional regulator
CIB87_17195	COG0110	maltose O-acetyltransferase activity
CIB87_17205	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CIB87_17210	COG0281	malic enzyme
CIB87_17270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CIB87_17275	COG2076	Multidrug Resistance protein
CIB87_17285	COG1621	beta-fructofuranosidase activity
CIB87_17295	COG1609	Transcriptional regulator
CIB87_17305	COG0697	spore germination
CIB87_17315	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CIB87_17400	COG0303	'Molybdopterin
CIB87_17410	COG0521	Mo-molybdopterin cofactor biosynthetic process
CIB87_17415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CIB87_17425	COG2244	polysaccharide biosynthetic process
CIB87_17445	COG2828	Protein conserved in bacteria
CIB87_17450	COG0583	DNA-binding transcription factor activity
CIB87_17455	COG2851	Citrate transporter
CIB87_17470	COG0670	Belongs to the BI1 family
CIB87_17490	COG0791	NLP P60 protein
CIB87_17495	COG2814	Major facilitator Superfamily
CIB87_17500	COG1846	Transcriptional regulator
CIB87_17525	COG1278	Cold shock
CIB87_17540	COG1113	amino acid transport
CIB87_17545	COG1113	amino acid transport
CIB87_17550	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_17555	COG0506	proline dehydrogenase activity
CIB87_17560	COG3878	Protein conserved in bacteria
CIB87_17575	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIB87_17590	COG0726	polysaccharide deacetylase
CIB87_17620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CIB87_17650	COG1247	-acetyltransferase
CIB87_17660	COG0789	Transcriptional regulator
CIB87_17665	COG0667	Aldo Keto reductase
CIB87_17675	COG0789	Transcriptional regulator
CIB87_17700	COG1621	beta-fructofuranosidase activity
CIB87_17705	COG4980	gas vesicle protein
CIB87_17730	COG1752	Esterase of the alpha-beta hydrolase superfamily
CIB87_17735	COG0577	efflux transmembrane transporter activity
CIB87_17740	COG1136	(ABC) transporter
CIB87_17750	COG0642	Histidine kinase
CIB87_17765	COG1289	transmembrane transporter activity
CIB87_17770	COG1937	Protein conserved in bacteria
CIB87_17785	COG3973	AAA domain
CIB87_17790	COG1024	Enoyl-CoA hydratase
CIB87_17795	COG1733	regulation of RNA biosynthetic process
CIB87_17800	COG2124	cytochrome p450
CIB87_17805	COG2259	Doxx family
CIB87_17820	COG0463	Glycosyl transferase, family 2
CIB87_17835	COG0791	NLP P60 protein
CIB87_17835	COG1388	LysM domain
CIB87_17840	COG0840	transmembrane signaling receptor activity
CIB87_17845	COG1846	Transcriptional regulator
CIB87_17855	COG0726	polysaccharide deacetylase
CIB87_17870	COG0833	amino acid
CIB87_17880	COG0405	Gamma-glutamyltransferase
CIB87_17900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CIB87_17905	COG0569	domain protein
CIB87_17915	COG1522	sequence-specific DNA binding
CIB87_17925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIB87_17930	COG0745	RESPONSE REGULATOR receiver
CIB87_17935	COG2770	Histidine kinase
CIB87_17935	COG2205	protein histidine kinase activity
CIB87_17940	COG2247	cell wall binding repeat
CIB87_17940	COG2385	sporulation resulting in formation of a cellular spore
CIB87_17945	COG1607	acyl-coa hydrolase
CIB87_17950	COG1802	Transcriptional regulator
CIB87_17955	COG0697	spore germination
CIB87_17965	COG0006	proline dipeptidase activity
CIB87_17975	COG1316	TRANSCRIPTIONal
CIB87_17985	COG2249	NAD(P)H dehydrogenase (quinone) activity
CIB87_17995	COG1174	glycine betaine transport
CIB87_18000	COG1125	glycine betaine transport
CIB87_18000	COG0517	IMP dehydrogenase activity
CIB87_18015	COG2814	Major facilitator Superfamily
CIB87_18025	COG0395	ABC-type sugar transport system, permease component
CIB87_18035	COG1653	transport
CIB87_18050	COG2205	protein histidine kinase activity
CIB87_18055	COG0730	response to heat
CIB87_18060	COG1301	dicarboxylic acid transport
CIB87_18090	COG1316	TRANSCRIPTIONal
CIB87_18095	COG1368	sulfuric ester hydrolase activity
CIB87_18105	COG0697	spore germination
CIB87_18110	COG1902	pentaerythritol trinitrate reductase activity
CIB87_18125	COG1113	amino acid transport
CIB87_18130	COG5505	Protein of unknown function (DUF819)
CIB87_18135	COG1309	transcriptional regulator
CIB87_18145	COG0583	DNA-binding transcription factor activity
CIB87_18150	COG0730	response to heat
CIB87_18155	COG1247	-acetyltransferase
CIB87_18160	COG2910	NAD(P)H-binding
CIB87_18170	COG1285	pathogenesis
CIB87_18175	COG4195	phage-related replication protein
CIB87_18185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIB87_18200	COG1113	amino acid transport
CIB87_18230	COG0463	Glycosyl transferase, family 2
CIB87_18260	COG2514	catechol 2,3-dioxygenase activity
CIB87_18280	COG1280	lysine exporter protein (LysE YggA)
CIB87_18285	COG1115	amino acid carrier protein
CIB87_18295	COG0385	Bile acid
CIB87_18300	COG0668	transmembrane transport
CIB87_18305	COG2340	Cysteine-rich secretory protein family
CIB87_18310	COG1253	flavin adenine dinucleotide binding
CIB87_18320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CIB87_18325	COG0589	response to stress
CIB87_18330	COG0205	6-phosphofructokinase activity
CIB87_18335	COG0791	NLP P60 protein
CIB87_18335	COG1388	LysM domain
CIB87_18345	COG0432	Pfam Uncharacterised protein family UPF0047
CIB87_18350	COG0697	spore germination
CIB87_18355	COG0814	amino acid
CIB87_18380	COG1131	(ABC) transporter
CIB87_18395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_18410	COG0584	glycerophosphoryl diester phosphodiesterase
CIB87_18420	COG1131	(ABC) transporter
CIB87_18445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CIB87_18445	COG1263	PTS System
CIB87_18450	COG3711	transcriptional antiterminator
CIB87_18455	COG2190	(PTS) system
CIB87_18465	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIB87_18480	COG0772	Belongs to the SEDS family
CIB87_18485	COG0659	secondary active sulfate transmembrane transporter activity
CIB87_18490	COG0813	purine-nucleoside phosphorylase activity
CIB87_18500	COG0671	phosphoesterase, PA-phosphatase related
CIB87_18505	COG4326	sporulation control protein
CIB87_18510	COG0515	serine threonine protein kinase
CIB87_18535	COG4479	Belongs to the UPF0346 family
CIB87_18540	COG3594	Acyltransferase
CIB87_18555	COG1509	lysine 2,3-aminomutase activity
CIB87_18560	COG0456	acetyltransferase
CIB87_18565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CIB87_18570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CIB87_18575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CIB87_18580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CIB87_18585	COG1301	dicarboxylic acid transport
CIB87_18595	COG4191	Histidine kinase
CIB87_18620	COG2755	lipolytic protein G-D-S-L family
CIB87_18625	COG1999	signal sequence binding
CIB87_18635	COG1307	EDD domain protein, DegV family
CIB87_18645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CIB87_18655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CIB87_18660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CIB87_18665	COG0788	formyltetrahydrofolate deformylase activity
CIB87_18670	COG1070	Carbohydrate kinase
CIB87_18700	COG0076	glutamate decarboxylase activity
CIB87_18720	COG0415	Belongs to the DNA photolyase family
CIB87_18725	COG3852	Histidine kinase
CIB87_18740	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_18750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CIB87_18760	COG4846	Membrane protein involved in cytochrome C biogenesis
CIB87_18765	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CIB87_18770	COG0785	Cytochrome C biogenesis protein
CIB87_18780	COG1132	(ABC) transporter
CIB87_18785	COG1132	(ABC) transporter
CIB87_18805	COG4224	UPF0291 protein
CIB87_18810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CIB87_18830	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CIB87_18835	COG0531	amino acid
CIB87_18845	COG0174	glutamine synthetase
CIB87_18850	COG0789	Transcriptional regulator
CIB87_18855	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CIB87_18860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CIB87_18865	COG2860	membrane
CIB87_18870	COG0464	growth
CIB87_18880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CIB87_18890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CIB87_18895	COG0531	amino acid
CIB87_18905	COG4550	Control of competence regulator ComK, YlbF/YmcA
CIB87_18910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIB87_18915	COG1013	pyruvate-flavodoxin oxidoreductase activity
CIB87_18920	COG0674	pyruvate-flavodoxin oxidoreductase activity
CIB87_18920	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CIB87_18930	COG2359	stage V sporulation protein S
CIB87_18935	COG1692	metallophosphoesterase
CIB87_18945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CIB87_18950	COG1546	Belongs to the CinA family
CIB87_18950	COG1058	Belongs to the CinA family
CIB87_18955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CIB87_18960	COG1426	Protein conserved in bacteria
CIB87_18975	COG0300	oxidoreductase activity
CIB87_18980	COG0612	Peptidase, M16
CIB87_18985	COG0612	Peptidase, M16
CIB87_19010	COG2188	Transcriptional regulator
CIB87_19015	COG1674	ftsk spoiiie
CIB87_19015	COG4980	gas vesicle protein
CIB87_19025	COG0740	serine-type endopeptidase activity
CIB87_19030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CIB87_19040	COG0527	aspartate kinase activity
CIB87_19045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CIB87_19050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CIB87_19055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CIB87_19060	COG1873	PFAM PRC-barrel domain
CIB87_19065	COG0612	Peptidase, M16
CIB87_19070	COG0726	polysaccharide deacetylase
CIB87_19075	COG1185	polyribonucleotide nucleotidyltransferase activity
CIB87_19080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CIB87_19085	COG0196	riboflavin kinase activity
CIB87_19100	COG1550	Protein conserved in bacteria
CIB87_19110	COG1358	cellular component organization or biogenesis
CIB87_19115	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CIB87_19120	COG0195	Participates in both transcription termination and antitermination
CIB87_19125	COG0779	Required for maturation of 30S ribosomal subunits
CIB87_19130	COG2176	DNA-directed DNA polymerase activity
CIB87_19135	COG0442	prolyl-tRNA aminoacylation
CIB87_19140	COG0750	zinc metalloprotease
CIB87_19150	COG4589	Belongs to the CDS family
CIB87_19160	COG0233	cytoplasmic translational termination
CIB87_19165	COG0528	UMP kinase activity
CIB87_19170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CIB87_19185	COG1191	sigma factor activity
CIB87_19190	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CIB87_19195	COG0835	chemotaxis
CIB87_19200	COG2198	Histidine kinase
CIB87_19200	COG0643	Histidine kinase
CIB87_19205	COG2201	protein-glutamate methylesterase activity
CIB87_19210	COG0455	bacterial-type flagellum organization
CIB87_19215	COG1419	protein localization to endoplasmic reticulum
CIB87_19220	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CIB87_19225	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CIB87_19230	COG1684	flagellar biosynthetic protein fliR
CIB87_19235	COG1987	bacterial-type flagellum assembly
CIB87_19240	COG1338	Plays a role in the flagellum-specific transport system
CIB87_19245	COG3190	flagellar
CIB87_19250	COG2201	protein-glutamate methylesterase activity
CIB87_19255	COG1776	CheC inhibitor of MCP methylation
CIB87_19255	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CIB87_19260	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CIB87_19265	COG1580	Controls the rotational direction of flagella during chemotaxis
CIB87_19270	COG1582	Flagellar protein (FlbD)
CIB87_19275	COG4786	Flagellar basal body rod
CIB87_19280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CIB87_19295	COG2882	bacterial-type flagellum organization
CIB87_19300	COG1157	protein secretion by the type III secretion system
CIB87_19305	COG1317	bacterial-type flagellum organization
CIB87_19310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CIB87_19315	COG1766	The M ring may be actively involved in energy transduction
CIB87_19320	COG1677	Flagellar hook-basal body complex protein FliE
CIB87_19325	COG1558	bacterial-type flagellum-dependent cell motility
CIB87_19330	COG1815	bacterial-type flagellum-dependent cell motility
CIB87_19335	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CIB87_19340	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CIB87_19350	COG4974	Belongs to the 'phage' integrase family
CIB87_19355	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CIB87_19360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIB87_19365	COG0758	DNA mediated transformation
CIB87_19370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CIB87_19375	COG0045	succinate-CoA ligase (ADP-forming) activity
CIB87_19395	COG0335	large ribosomal subunit rRNA binding
CIB87_19405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CIB87_19415	COG1837	Belongs to the UPF0109 family
CIB87_19420	COG0228	four-way junction DNA binding
CIB87_19425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CIB87_19435	COG0552	protein localization to endoplasmic reticulum
CIB87_19440	COG1196	nuclear chromosome segregation
CIB87_19450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CIB87_19455	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_19460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CIB87_19465	COG0416	fatty acid biosynthetic process
CIB87_19470	COG1349	DNA-binding transcription factor activity
CIB87_19475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CIB87_19480	COG1760	l-serine dehydratase
CIB87_19485	COG1760	l-serine dehydratase
CIB87_19495	COG1461	Dihydroxyacetone kinase
CIB87_19500	COG1302	Protein conserved in bacteria
CIB87_19505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CIB87_19515	COG1564	THIamine pyrophosphokinase
CIB87_19520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CIB87_19525	COG1162	GTPase activity
CIB87_19530	COG0515	serine threonine protein kinase
CIB87_19530	COG2815	serine threonine protein kinase
CIB87_19535	COG0631	protein serine/threonine phosphatase activity
CIB87_19545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CIB87_19545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIB87_19550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CIB87_19560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CIB87_19565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CIB87_19570	COG1758	RNA polymerase activity
CIB87_19575	COG0194	GDP metabolic process
CIB87_19580	COG2052	Domain of unknown function (DUF370)
CIB87_19585	COG1561	YicC-like family, N-terminal region
CIB87_19590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CIB87_19600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CIB87_19630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CIB87_19645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CIB87_19650	COG0564	pseudouridine synthase activity
CIB87_19655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CIB87_19670	COG3599	regulation of cell shape
CIB87_19675	COG2302	S4 RNA-binding domain
CIB87_19680	COG0762	integral membrane protein
CIB87_19685	COG1799	cell septum assembly
CIB87_19690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CIB87_19700	COG1873	PFAM PRC-barrel domain
CIB87_19705	COG1191	sigma factor activity
CIB87_19710	COG1191	sigma factor activity
CIB87_19720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CIB87_19725	COG0849	cell division
CIB87_19730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CIB87_19735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CIB87_19740	COG0772	Belongs to the SEDS family
CIB87_19745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CIB87_19750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIB87_19755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CIB87_19760	COG0768	penicillin binding
CIB87_19770	COG4839	cell division protein FtsL
CIB87_19780	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CIB87_19790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CIB87_19795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CIB87_19800	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CIB87_19805	COG0439	Biotin carboxylase
CIB87_19810	COG0454	-acetyltransferase
CIB87_19820	COG1024	Enoyl-CoA hydratase
CIB87_19825	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CIB87_19830	COG1399	metal-binding, possibly nucleic acid-binding protein
CIB87_19835	COG1323	Belongs to the UPF0348 family
CIB87_19840	COG3480	Lon protease (S16) C-terminal proteolytic domain
CIB87_19845	COG1752	Esterase of the alpha-beta hydrolase superfamily
CIB87_19850	COG3314	Sporulation integral membrane protein YlbJ
CIB87_19855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CIB87_19860	COG0742	ribosomal rna small subunit methyltransferase
CIB87_19870	COG4471	UPF0298 protein
CIB87_19880	COG3679	Belongs to the UPF0342 family
CIB87_19900	COG4347	Protein of unknown function (DUF1405)
CIB87_19910	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CIB87_19925	COG5582	Belongs to the UPF0302 family
CIB87_19930	COG0457	Tetratricopeptide repeat
CIB87_19935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CIB87_19940	COG0287	Prephenate dehydrogenase
CIB87_19945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIB87_19950	COG0159	tryptophan synthase activity
CIB87_19960	COG0135	phosphoribosylanthranilate isomerase activity
CIB87_19965	COG0134	indole-3-glycerol-phosphate synthase activity
CIB87_19970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CIB87_19980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CIB87_19985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CIB87_19990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CIB87_19995	COG0105	UTP biosynthetic process
CIB87_20000	COG0142	geranyltranstransferase activity
CIB87_20005	COG2226	methyltransferase
CIB87_20010	COG0142	geranyltranstransferase activity
CIB87_20020	COG0302	gtp cyclohydrolase
CIB87_20025	COG0776	regulation of translation
CIB87_20030	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CIB87_20065	COG2271	Major facilitator Superfamily
CIB87_20070	COG1304	FMN binding
CIB87_20075	COG0539	negative regulation of cytoplasmic translation
CIB87_20085	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CIB87_20095	COG2959	enzyme of heme biosynthesis
CIB87_20100	COG3773	Cell wall hydrolase
CIB87_20100	COG3409	Peptidoglycan-binding domain 1 protein
CIB87_20105	COG2339	peptidase activity
CIB87_20110	COG0252	asparaginase activity
CIB87_20115	COG0492	ferredoxin-NADP+ reductase activity
CIB87_20120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CIB87_20125	COG4862	establishment of competence for transformation
CIB87_20130	COG0789	Transcriptional regulator
CIB87_20135	COG1408	metallophosphoesterase
CIB87_20150	COG1266	CAAX protease self-immunity
CIB87_20155	COG0514	ATP-dependent DNA helicase (RecQ)
CIB87_20165	COG1141	Ferredoxin
CIB87_20170	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CIB87_20175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CIB87_20180	COG0739	heme binding
CIB87_20185	COG5002	protein histidine kinase activity
CIB87_20190	COG0745	RESPONSE REGULATOR receiver
CIB87_20195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIB87_20200	COG1333	cytochrome c biogenesis protein
CIB87_20205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIB87_20210	COG1187	pseudouridine synthase activity
CIB87_20215	COG0700	Nucleoside recognition
CIB87_20220	COG2715	membrane protein required for spore maturation
CIB87_20225	COG1686	Belongs to the peptidase S11 family
CIB87_20230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CIB87_20235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CIB87_20245	COG1547	Domain of unknown function (DUF309)
CIB87_20255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CIB87_20260	COG4086	secreted protein
CIB87_20270	COG0697	spore germination
CIB87_20285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIB87_20320	COG1686	Belongs to the peptidase S11 family
CIB87_20335	COG4974	Belongs to the 'phage' integrase family
CIB87_20345	COG0735	belongs to the Fur family
CIB87_20350	COG1300	Membrane
CIB87_20355	COG0494	nUDIX hydrolase
CIB87_20365	COG0667	Aldo Keto reductase
CIB87_20380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CIB87_20390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CIB87_20395	COG1073	alpha beta
CIB87_20410	COG0300	oxidoreductase activity
CIB87_20415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIB87_20420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CIB87_20425	COG1902	pentaerythritol trinitrate reductase activity
CIB87_20435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CIB87_20440	COG1012	belongs to the aldehyde dehydrogenase family
CIB87_20445	COG2508	Transcriptional regulator
CIB87_20465	COG0167	dihydroorotate dehydrogenase activity
CIB87_20465	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CIB87_20470	COG0493	'glutamate synthase
CIB87_20475	COG2195	Cleaves the N-terminal amino acid of tripeptides
CIB87_20480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CIB87_20490	COG1376	ErfK ybiS ycfS ynhG family protein
CIB87_20495	COG4129	membrane
CIB87_20500	COG1126	abc transporter atp-binding protein
CIB87_20505	COG0765	amino acid transport
CIB87_20510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CIB87_20520	COG1703	isobutyryl-CoA mutase activity
CIB87_20525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIB87_20525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIB87_20535	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIB87_20540	COG0022	dehydrogenase e1 component
CIB87_20545	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CIB87_20550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CIB87_20565	COG0280	phosphate acetyltransferase
CIB87_20570	COG3290	protein histidine kinase activity
CIB87_20570	COG3829	transcription factor binding
CIB87_20580	COG0584	glycerophosphoryl diester phosphodiesterase
CIB87_20585	COG3093	addiction module antidote protein HigA
CIB87_20590	COG3104	oligopeptide transport
CIB87_20595	COG0745	RESPONSE REGULATOR receiver
CIB87_20600	COG0750	zinc metalloprotease
CIB87_20605	COG0497	DNA recombination
CIB87_20615	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CIB87_20630	COG1722	exodeoxyribonuclease VII activity
CIB87_20640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIB87_20645	COG1302	Protein conserved in bacteria
CIB87_20650	COG0439	Biotin carboxylase
CIB87_20655	COG0511	ligase activity, forming carbon-carbon bonds
CIB87_20695	COG3854	ATPases associated with a variety of cellular activities
CIB87_20705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CIB87_20710	COG0006	proline dipeptidase activity
CIB87_20715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CIB87_20725	COG3872	metal-dependent enzyme
CIB87_20735	COG1752	Esterase of the alpha-beta hydrolase superfamily
CIB87_20740	COG1321	iron dependent repressor
CIB87_20745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CIB87_20750	COG0095	Lipoate-protein ligase
CIB87_20755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIB87_20765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIB87_20770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CIB87_20775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CIB87_20805	COG4970	Tfp pilus assembly protein FimT
CIB87_20810	COG4537	Required for transformation and DNA binding
CIB87_20815	COG1459	type II secretion system
CIB87_20820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CIB87_20825	COG1393	Belongs to the ArsC family
CIB87_20835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIB87_20845	COG2866	Carboxypeptidase
CIB87_20850	COG1940	carbohydrate kinase activity
CIB87_20855	COG4483	Protein conserved in bacteria
CIB87_20860	COG0705	Rhomboid family
CIB87_20860	COG0457	Tetratricopeptide repeat
CIB87_20870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CIB87_20880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CIB87_20895	COG0704	Plays a role in the regulation of phosphate uptake
CIB87_20910	COG0477	Major facilitator Superfamily
CIB87_20945	COG2839	Protein conserved in bacteria
CIB87_20950	COG1283	sodium-dependent phosphate transmembrane transporter activity
CIB87_20960	COG2814	Major facilitator Superfamily
CIB87_20965	COG1388	LysM domain
CIB87_20970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CIB87_20975	COG4709	membrane
CIB87_20980	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CIB87_20985	COG0735	belongs to the Fur family
CIB87_20990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CIB87_20995	COG1121	(ABC) transporter
CIB87_21005	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CIB87_21010	COG0513	Belongs to the DEAD box helicase family
CIB87_21020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CIB87_21025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CIB87_21030	COG2384	SAM-dependent methyltransferase
CIB87_21035	COG2010	Cytochrome c
CIB87_21040	COG1960	acyl-CoA dehydrogenase activity
CIB87_21045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CIB87_21050	COG0358	DNA primase activity
CIB87_21055	COG1671	Belongs to the UPF0178 family
CIB87_21060	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CIB87_21065	COG0517	IMP dehydrogenase activity
CIB87_21070	COG1381	Involved in DNA repair and RecF pathway recombination
CIB87_21080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CIB87_21085	COG0295	cytidine deaminase activity
CIB87_21090	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CIB87_21100	COG1480	7TM receptor with intracellular HD hydrolase
CIB87_21105	COG1702	phosphate starvation-inducible protein PhoH
CIB87_21130	COG1030	water channel activity
CIB87_21135	COG1610	YqeY-like protein
CIB87_21140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CIB87_21145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIB87_21150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CIB87_21155	COG2264	protein methyltransferase activity
CIB87_21170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CIB87_21175	COG1420	regulation of RNA biosynthetic process
CIB87_21180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIB87_21185	COG0481	GTPase activity
CIB87_21195	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CIB87_21200	COG0268	Binds directly to 16S ribosomal RNA
CIB87_21205	COG1466	dna polymerase III delta subunit
CIB87_21215	COG2333	competence protein COMEC
CIB87_21215	COG0658	competence protein
CIB87_21220	COG2131	deaminase
CIB87_21225	COG1596	polysaccharide export
CIB87_21225	COG1555	photosystem II stabilization
CIB87_21230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CIB87_21235	COG2226	methyltransferase
CIB87_21240	COG0799	negative regulation of ribosome biogenesis
CIB87_21245	COG1713	HD superfamily hydrolase involved in NAD metabolism
CIB87_21250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CIB87_21255	COG1534	Rna-binding protein
CIB87_21260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CIB87_21265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CIB87_21270	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CIB87_21280	COG0688	phosphatidylethanolamine metabolic process
CIB87_21285	COG1183	phosphatidylcholine synthase activity
CIB87_21295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CIB87_21410	COG0626	cystathionine gamma-synthase activity
CIB87_21415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIB87_21420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CIB87_21425	COG2226	methyltransferase
CIB87_21440	COG0768	penicillin binding
CIB87_21445	COG1335	isochorismatase
CIB87_21450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CIB87_21455	COG0572	uridine kinase
CIB87_21475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CIB87_21480	COG3906	Belongs to the UPF0473 family
CIB87_21490	COG4472	Bacterial protein of unknown function (DUF965)
CIB87_21500	COG0628	permease
CIB87_21515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CIB87_21525	COG0482	sulfurtransferase activity
CIB87_21530	COG1104	cysteine desulfurase activity
CIB87_21535	COG1959	2 iron, 2 sulfur cluster binding
CIB87_21540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CIB87_21545	COG0581	inorganic phosphate transmembrane transporter activity
CIB87_21550	COG0573	inorganic phosphate transmembrane transporter activity
CIB87_21555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CIB87_21560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CIB87_21570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CIB87_21575	COG0124	histidyl-tRNA synthetase
CIB87_21585	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIB87_21590	COG1490	D-aminoacyl-tRNA deacylase activity
CIB87_21595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CIB87_21600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIB87_21605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CIB87_21605	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CIB87_21610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CIB87_21610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CIB87_21620	COG2244	polysaccharide biosynthetic process
CIB87_21625	COG2323	membrane
CIB87_21635	COG1862	Preprotein translocase
CIB87_21645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CIB87_21655	COG2255	four-way junction helicase activity
CIB87_21685	COG1388	LysM domain
CIB87_21690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CIB87_21695	COG0157	Belongs to the NadC ModD family
CIB87_21700	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CIB87_21705	COG1104	cysteine desulfurase activity
CIB87_21710	COG1827	regulation of RNA biosynthetic process
CIB87_21715	COG0077	Prephenate dehydratase
CIB87_21720	COG4492	Belongs to the UPF0735 family
CIB87_21725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CIB87_21730	COG3290	protein histidine kinase activity
CIB87_21740	COG2868	ribosomal protein
CIB87_21750	COG1530	ribonuclease E activity
CIB87_21755	COG1994	Peptidase M50
CIB87_21760	COG0739	heme binding
CIB87_21765	COG2894	cell division
CIB87_21770	COG0850	regulation of cytokinetic process
CIB87_21775	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CIB87_21780	COG1792	Involved in formation and maintenance of cell shape
CIB87_21785	COG1077	Cell shape determining protein MreB Mrl
CIB87_21790	COG2003	Belongs to the UPF0758 family
CIB87_21805	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CIB87_21815	COG2322	membrane
CIB87_21820	COG0285	dihydrofolate synthase activity
CIB87_21825	COG0525	valine-tRNA ligase activity
CIB87_21835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CIB87_21840	COG1388	LysM domain
CIB87_21845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CIB87_21850	COG0113	porphobilinogen synthase activity
CIB87_21855	COG1587	Uroporphyrinogen-III synthase
CIB87_21860	COG0181	hydroxymethylbilane synthase activity
CIB87_21865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIB87_21880	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CIB87_21885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CIB87_21890	COG1067	ATP-dependent peptidase activity
CIB87_21890	COG0470	DNA polymerase III
CIB87_21895	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CIB87_21900	COG0544	peptidyl-prolyl cis-trans isomerase activity
CIB87_21905	COG0457	Tetratricopeptide repeat
CIB87_21905	COG1477	protein flavinylation
CIB87_21910	COG0066	3-isopropylmalate dehydratase activity
CIB87_21915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CIB87_21925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CIB87_21930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CIB87_21935	COG0440	acetolactate synthase activity
CIB87_21940	COG0028	Belongs to the TPP enzyme family
CIB87_21950	COG0622	Phosphoesterase
CIB87_21960	COG5401	PFAM Sporulation and spore germination
CIB87_21965	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CIB87_21970	COG1846	Transcriptional regulator
CIB87_21980	COG0306	phosphate transporter
CIB87_21985	COG1392	Phosphate transport regulator
CIB87_21990	COG0768	penicillin binding
CIB87_22000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIB87_22005	COG0431	NADPH-dependent FMN reductase
CIB87_22010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIB87_22015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CIB87_22020	COG1116	anion transmembrane transporter activity
CIB87_22025	COG0475	glutathione-regulated potassium exporter activity
CIB87_22030	COG0490	domain, Protein
CIB87_22040	COG2197	response regulator
CIB87_22045	COG0824	Thioesterase
CIB87_22050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CIB87_22055	COG1053	succinate dehydrogenase
CIB87_22060	COG2009	succinate dehydrogenase
CIB87_22065	COG1719	4-vinyl reductase, 4VR
CIB87_22070	COG0527	aspartate kinase activity
CIB87_22080	COG3118	belongs to the thioredoxin family
CIB87_22085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CIB87_22090	COG2086	electron transfer activity
CIB87_22095	COG1024	Enoyl-CoA hydratase
CIB87_22100	COG1309	transcriptional regulator
CIB87_22105	COG0318	PFAM AMP-dependent synthetase and ligase
CIB87_22110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CIB87_22115	COG3766	membrane
CIB87_22120	COG1193	negative regulation of DNA recombination
CIB87_22125	COG1796	DNA polymerase
CIB87_22125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CIB87_22130	COG1286	toxin biosynthetic process
CIB87_22135	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CIB87_22140	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CIB87_22145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIB87_22145	COG0072	phenylalanine-tRNA ligase activity
CIB87_22155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CIB87_22165	COG1363	Peptidase, m42
CIB87_22185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CIB87_22190	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CIB87_22195	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CIB87_22200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CIB87_22210	COG1484	DNA-dependent DNA replication
CIB87_22215	COG3611	Membrane attachment protein
CIB87_22220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CIB87_22230	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CIB87_22235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CIB87_22245	COG1971	Probably functions as a manganese efflux pump
CIB87_22250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CIB87_22255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIB87_22255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIB87_22260	COG5002	protein histidine kinase activity
CIB87_22265	COG0745	RESPONSE REGULATOR receiver
CIB87_22275	COG0039	L-malate dehydrogenase activity
CIB87_22280	COG0538	isocitrate dehydrogenase activity
CIB87_22285	COG0372	Belongs to the citrate synthase family
CIB87_22295	COG0628	permease
CIB87_22300	COG3030	protein affecting phage T7 exclusion by the F plasmid
CIB87_22310	COG0825	malonyl-CoA metabolic process
CIB87_22315	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CIB87_22320	COG2186	Transcriptional regulator
CIB87_22325	COG0281	malic enzyme
CIB87_22330	COG0587	DNA-directed DNA polymerase activity
CIB87_22345	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CIB87_22360	COG4109	DRTGG domain
CIB87_22375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CIB87_22385	COG0165	Argininosuccinate lyase
CIB87_22390	COG0137	argininosuccinate synthase activity
CIB87_22405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CIB87_22410	COG0827	DNA restriction-modification system
CIB87_22415	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CIB87_22420	COG3874	Sporulation protein YtfJ
CIB87_22430	COG1714	RDD family
CIB87_22435	COG0616	signal peptide processing
CIB87_22440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CIB87_22445	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CIB87_22455	COG0301	tRNA thio-modification
CIB87_22460	COG1104	cysteine desulfurase activity
CIB87_22465	COG1114	Component of the transport system for branched-chain amino acids
CIB87_22470	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CIB87_22475	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CIB87_22480	COG1309	transcriptional regulator
CIB87_22485	COG1956	GAF domain-containing protein
CIB87_22495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CIB87_22500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CIB87_22505	COG0454	-acetyltransferase
CIB87_22510	COG0517	IMP dehydrogenase activity
CIB87_22515	COG0123	including yeast histone deacetylase and acetoin utilization protein
CIB87_22535	COG1605	Chorismate mutase
CIB87_22535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CIB87_22540	COG3118	belongs to the thioredoxin family
CIB87_22545	COG4980	gas vesicle protein
CIB87_22560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CIB87_22570	COG1674	ftsk spoiiie
CIB87_22575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIB87_22580	COG4848	Belongs to the UPF0354 family
CIB87_22585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIB87_22590	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CIB87_22595	COG1363	Peptidase, m42
CIB87_22600	COG5584	Small secreted protein
CIB87_22605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIB87_22610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CIB87_22620	COG0510	thiamine kinase activity
CIB87_22625	COG1523	belongs to the glycosyl hydrolase 13 family
CIB87_22640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIB87_22645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CIB87_22650	COG1349	DNA-binding transcription factor activity
CIB87_22655	COG1187	pseudouridine synthase activity
CIB87_22660	COG2244	polysaccharide biosynthetic process
CIB87_22665	COG2081	HI0933 family
CIB87_22680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIB87_22685	COG0495	leucyl-tRNA aminoacylation
CIB87_22690	COG2610	gluconate transmembrane transporter activity
CIB87_22695	COG2814	Major facilitator Superfamily
CIB87_22710	COG1242	4 iron, 4 sulfur cluster binding
CIB87_22715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CIB87_22725	COG2267	carboxylic ester hydrolase activity
CIB87_22730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CIB87_22735	COG0671	phosphoesterase, PA-phosphatase related
CIB87_22740	COG0438	transferase activity, transferring glycosyl groups
CIB87_22740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CIB87_22745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CIB87_22750	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CIB87_22760	COG1506	peptidase
CIB87_22765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CIB87_22770	COG1116	anion transmembrane transporter activity
CIB87_22775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIB87_22780	COG0494	nUDIX hydrolase
CIB87_22790	COG4824	toxin secretion phage lysis holin
CIB87_22795	COG0783	Belongs to the Dps family
CIB87_22805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CIB87_22810	COG0288	reversible hydration of carbon dioxide
CIB87_22815	COG0523	cobalamin synthesis protein
CIB87_22825	COG0254	rRNA binding
CIB87_22830	COG1271	oxidase subunit
CIB87_22835	COG1294	oxidase, subunit
CIB87_22840	COG0716	FMN binding
CIB87_22865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CIB87_22870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CIB87_22875	COG4948	Mandelate Racemase Muconate Lactonizing
CIB87_22880	COG0318	PFAM AMP-dependent synthetase and ligase
CIB87_22885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CIB87_22890	COG0596	Alpha beta hydrolase
CIB87_22895	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CIB87_22900	COG1169	isochorismate synthase
CIB87_22905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CIB87_22915	COG0058	SHG alpha-glucan phosphorylase activity
CIB87_22920	COG0297	glycogen (starch) synthase activity
CIB87_22925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CIB87_23060	COG0318	PFAM AMP-dependent synthetase and ligase
CIB87_23065	COG1285	pathogenesis
CIB87_23085	COG0529	Catalyzes the synthesis of activated sulfate
CIB87_23095	COG0306	phosphate transporter
CIB87_23105	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CIB87_23110	COG0346	lactoylglutathione lyase activity
CIB87_23115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CIB87_23125	COG0166	Belongs to the GPI family
CIB87_23135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CIB87_23135	COG2111	Na H antiporter
CIB87_23140	COG2111	Na H antiporter
CIB87_23145	COG1006	Multisubunit Na H antiporter MnhC subunit
CIB87_23150	COG0651	ATP synthesis coupled electron transport
CIB87_23155	COG1863	multisubunit Na H antiporter MnhE subunit
CIB87_23160	COG2212	antiporter activity
CIB87_23165	COG1320	monovalent cation:proton antiporter activity
CIB87_23170	COG1979	alcohol dehydrogenase
CIB87_23175	COG2155	Conserved Protein
CIB87_23180	COG1098	S1 RNA binding domain
CIB87_23185	COG0436	Aminotransferase
CIB87_23190	COG1522	sequence-specific DNA binding
CIB87_23195	COG2267	carboxylic ester hydrolase activity
CIB87_23200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CIB87_23205	COG2032	superoxide dismutase activity
CIB87_23220	COG5018	Exonuclease
CIB87_23225	COG2050	protein possibly involved in aromatic compounds catabolism
CIB87_23235	COG1418	mRNA catabolic process
CIB87_23245	COG2056	Na+-H+ antiporter family
CIB87_23250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIB87_23255	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CIB87_23260	COG3584	3D domain protein
CIB87_23270	COG1252	NADH dehydrogenase
CIB87_23275	COG0492	ferredoxin-NADP+ reductase activity
CIB87_23285	COG0316	Belongs to the HesB IscA family
CIB87_23290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CIB87_23295	COG4844	belongs to the
CIB87_23300	COG1252	NADH dehydrogenase
CIB87_23305	COG4837	Protein of unknown function (DUF1462)
CIB87_23310	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CIB87_23320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CIB87_23325	COG0460	homoserine dehydrogenase
CIB87_23330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CIB87_23335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CIB87_23340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CIB87_23345	COG0647	UMP catabolic process
CIB87_23350	COG2445	Protein of unknown function DUF86
CIB87_23360	COG4470	Protein conserved in bacteria
CIB87_23375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CIB87_23380	COG0739	heme binding
CIB87_23390	COG0733	neurotransmitter:sodium symporter activity
CIB87_23400	COG3377	Domain of unknown function (DUF1805)
CIB87_23405	COG1801	Protein of unknown function DUF72
CIB87_23410	COG0719	Fe-S assembly protein
CIB87_23415	COG0822	iron-sulfur transferase activity
CIB87_23420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CIB87_23425	COG0719	Fe-S assembly protein
CIB87_23430	COG0396	ATPase activity
CIB87_23435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CIB87_23440	COG1464	Belongs to the NlpA lipoprotein family
CIB87_23445	COG2011	ABC-type metal ion transport system permease component
CIB87_23450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CIB87_23455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIB87_23460	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CIB87_23470	COG0509	glycine decarboxylation via glycine cleavage system
CIB87_23475	COG1393	Belongs to the ArsC family
CIB87_23480	COG1960	acyl-CoA dehydrogenase activity
CIB87_23485	COG0183	Belongs to the thiolase family
CIB87_23490	COG1024	Enoyl-CoA hydratase
CIB87_23490	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIB87_23515	COG1120	ATPase activity
CIB87_23520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIB87_23525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIB87_23530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIB87_23540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIB87_23545	COG1309	transcriptional regulator
CIB87_23555	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_23560	COG0477	Major facilitator Superfamily
CIB87_23565	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CIB87_23570	COG0583	DNA-binding transcription factor activity
CIB87_23580	COG0672	)-iron permease
CIB87_23585	COG5002	protein histidine kinase activity
CIB87_23585	COG3850	Histidine kinase
CIB87_23590	COG0745	RESPONSE REGULATOR receiver
CIB87_23595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CIB87_23600	COG0671	phosphoesterase, PA-phosphatase related
CIB87_23610	COG1846	Transcriptional regulator
CIB87_23615	COG0778	Nitroreductase
CIB87_23620	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CIB87_23625	COG0314	molybdopterin synthase activity
CIB87_23630	COG1763	Mo-molybdopterin cofactor biosynthetic process
CIB87_23635	COG0303	'Molybdopterin
CIB87_23640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CIB87_23645	COG0746	molybdenum cofactor guanylyltransferase activity
CIB87_23655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CIB87_23660	COG5609	conserved protein (DUF2294)
CIB87_23665	COG3383	formate dehydrogenase (NAD+) activity
CIB87_23670	COG2427	Protein of unknown function (DUF1641)
CIB87_23675	COG0725	ABC transporter, periplasmic molybdate-binding protein
CIB87_23680	COG4149	molybdate abc transporter
CIB87_23690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CIB87_23695	COG0557	exoribonuclease II activity
CIB87_23700	COG1647	Serine aminopeptidase, S33
CIB87_23705	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CIB87_23745	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CIB87_23765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIB87_23775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CIB87_23780	COG1660	Displays ATPase and GTPase activities
CIB87_23785	COG1051	belongs to the nudix hydrolase family
CIB87_23790	COG0492	ferredoxin-NADP+ reductase activity
CIB87_23795	COG0457	Tetratricopeptide repeat
CIB87_23800	COG0140	phosphoribosyl-ATP diphosphatase activity
CIB87_23800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CIB87_23805	COG0107	imidazoleglycerol-phosphate synthase activity
CIB87_23810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CIB87_23815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CIB87_23820	COG0131	Imidazoleglycerol-phosphate dehydratase
CIB87_23825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CIB87_23830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CIB87_23835	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CIB87_23840	COG0110	maltose O-acetyltransferase activity
CIB87_23845	COG0546	phosphoglycolate phosphatase activity
CIB87_23850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CIB87_23855	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CIB87_23860	COG1950	PFAM Membrane protein of
CIB87_23870	COG3595	metallopeptidase activity
CIB87_23880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CIB87_23885	COG0556	nucleotide-excision repair
CIB87_23890	COG2204	response regulator
CIB87_23895	COG0506	proline dehydrogenase activity
CIB87_23905	COG4897	Protein conserved in bacteria
CIB87_23910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIB87_23915	COG3409	Peptidoglycan-binding domain 1 protein
CIB87_23915	COG0793	Belongs to the peptidase S41A family
CIB87_23920	COG0739	heme binding
CIB87_23925	COG2177	Part of the ABC transporter FtsEX involved in
CIB87_23930	COG2884	Cell division ATP-binding protein ftsE
CIB87_23935	COG0655	NAD(P)H dehydrogenase (quinone) activity
CIB87_23945	COG0805	protein transport
CIB87_23950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIB87_23955	COG3540	Alkaline phosphatase
CIB87_23965	COG0653	protein targeting
CIB87_23970	COG0456	acetyltransferase
CIB87_23975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CIB87_23985	COG1516	flagellar protein fliS
CIB87_23990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CIB87_24000	COG1113	amino acid transport
CIB87_24015	COG1454	alcohol dehydrogenase
CIB87_24020	COG1510	regulation of RNA biosynthetic process
CIB87_24025	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CIB87_24030	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CIB87_24035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIB87_24040	COG4786	Flagellar basal body rod
CIB87_24040	COG1256	bacterial-type flagellum assembly
CIB87_24060	COG1040	competence protein
CIB87_24065	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CIB87_24070	COG1307	EDD domain protein, DegV family
CIB87_24075	COG1728	Protein conserved in bacteria
CIB87_24085	COG2197	response regulator
CIB87_24090	COG4585	Histidine kinase
CIB87_24095	COG1739	Uncharacterized protein family UPF0029
CIB87_24100	COG1316	TRANSCRIPTIONal
CIB87_24105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIB87_24110	COG1585	Membrane protein implicated in regulation of membrane protease activity
CIB87_24115	COG2268	Band 7 protein
CIB87_24130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CIB87_24140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CIB87_24145	COG0791	NLP P60 protein
CIB87_24145	COG1388	LysM domain
CIB87_24150	COG0629	single-stranded DNA binding
CIB87_24170	COG4786	Flagellar basal body rod
CIB87_24175	COG4786	Flagellar basal body rod
CIB87_24180	COG1077	Cell shape determining protein MreB Mrl
CIB87_24185	COG1609	Transcriptional regulator
CIB87_24190	COG0739	heme binding
CIB87_24195	COG2385	sporulation resulting in formation of a cellular spore
CIB87_24210	COG4836	Membrane
CIB87_24215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CIB87_24220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CIB87_24225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CIB87_24230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CIB87_24235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CIB87_24240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CIB87_24245	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CIB87_24250	COG0356	it plays a direct role in the translocation of protons across the membrane
CIB87_24265	COG1404	Belongs to the peptidase S8 family
CIB87_24270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CIB87_24275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CIB87_24290	COG0698	ribose 5-phosphate isomerase
CIB87_24300	COG1971	Probably functions as a manganese efflux pump
CIB87_24305	COG0009	L-threonylcarbamoyladenylate synthase
CIB87_24325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CIB87_24340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CIB87_24350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CIB87_24355	COG0191	fructose-bisphosphate aldolase activity
CIB87_24360	COG2204	response regulator
CIB87_24365	COG4821	SIS domain
CIB87_24370	COG0504	CTP synthase activity
CIB87_24380	COG1703	isobutyryl-CoA mutase activity
CIB87_24380	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIB87_24380	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIB87_24390	COG1960	acyl-CoA dehydrogenase activity
CIB87_24395	COG1960	acyl-CoA dehydrogenase activity
CIB87_24400	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIB87_24405	COG0183	Belongs to the thiolase family
CIB87_24410	COG0247	lactate metabolic process
CIB87_24410	COG2181	nitrate reductase activity
CIB87_24415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIB87_24430	COG4506	Protein conserved in bacteria
CIB87_24435	COG0010	Belongs to the arginase family
CIB87_24440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CIB87_24445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIB87_24460	COG1994	Peptidase M50
CIB87_24465	COG1942	4-Oxalocrotonate Tautomerase
CIB87_24470	COG3465	dGTPase activity
CIB87_24475	COG1078	dGTPase activity
CIB87_24480	COG4844	belongs to the
CIB87_24490	COG0095	Lipoate-protein ligase
CIB87_24495	COG0280	phosphate acetyltransferase
CIB87_24505	COG3773	Cell wall hydrolase
CIB87_24515	COG2363	Small membrane protein
CIB87_24525	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CIB87_24535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CIB87_24540	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CIB87_24545	COG2508	Transcriptional regulator
CIB87_24545	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CIB87_24550	COG0686	Belongs to the AlaDH PNT family
CIB87_24560	COG0351	phosphomethylpyrimidine kinase
CIB87_24565	COG0561	phosphatase activity
CIB87_24570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CIB87_24575	COG2190	(PTS) system
CIB87_24575	COG1263	PTS System
CIB87_24575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CIB87_24585	COG0438	transferase activity, transferring glycosyl groups
CIB87_24590	COG2246	polysaccharide biosynthetic process
CIB87_24595	COG0463	Glycosyl transferase, family 2
CIB87_24605	COG0728	peptidoglycan biosynthetic process
CIB87_24615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CIB87_24620	COG4988	ABC transporter
CIB87_24625	COG1294	oxidase, subunit
CIB87_24630	COG1271	oxidase subunit
CIB87_24635	COG3610	response to peptide
CIB87_24640	COG2966	Psort location CytoplasmicMembrane, score
CIB87_24645	COG1609	Transcriptional regulator
CIB87_24655	COG2814	Major facilitator Superfamily
CIB87_24670	COG1966	Carbon starvation protein
CIB87_24680	COG0753	catalase activity
CIB87_24695	COG0471	metal ion transport
CIB87_24700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CIB87_24710	COG0745	RESPONSE REGULATOR receiver
CIB87_24715	COG5002	protein histidine kinase activity
CIB87_24730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CIB87_24735	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CIB87_24745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIB87_24750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CIB87_24755	COG4853	Protein conserved in bacteria
CIB87_24765	COG5002	protein histidine kinase activity
CIB87_24770	COG0745	RESPONSE REGULATOR receiver
CIB87_24795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CIB87_24800	COG0305	Participates in initiation and elongation during chromosome replication
CIB87_24810	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CIB87_24820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CIB87_24835	COG0012	GTP binding
CIB87_24840	COG4481	Protein conserved in bacteria
CIB87_24845	COG0668	transmembrane transport
CIB87_24850	COG3949	Membrane
CIB87_24860	COG1475	DNA binding
CIB87_24865	COG1192	Involved in chromosome partitioning
CIB87_24870	COG1475	DNA binding
CIB87_24880	COG0445	tRNA wobble uridine modification
CIB87_24885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CIB87_24890	COG1847	R3H domain protein
CIB87_24895	COG0706	membrane insertase activity
CIB87_24900	COG0594	ribonuclease P activity
CIB87_24905	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CIB87_24910	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CIB87_24915	COG0592	DNA-directed DNA polymerase activity
CIB87_24920	COG2501	S4 domain
CIB87_24925	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIB87_24930	COG0187	DNA topoisomerase II activity
CIB87_24935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CIB87_24970	COG0516	GMP reductase activity
CIB87_24970	COG0517	IMP dehydrogenase activity
CIB87_24985	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CIB87_25000	COG1428	Deoxynucleoside kinase
CIB87_25005	COG1428	Deoxynucleoside kinase
CIB87_25010	COG3858	chitin binding
CIB87_25010	COG1388	LysM domain
CIB87_25015	COG1335	isochorismatase
CIB87_25020	COG0590	tRNA wobble adenosine to inosine editing
CIB87_25030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CIB87_25035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CIB87_25040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CIB87_25145	COG1982	Orn Lys Arg decarboxylase major
CIB87_25150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CIB87_25155	COG3870	Protein conserved in bacteria
CIB87_25160	COG0470	DNA polymerase III
CIB87_25165	COG1774	PSP1 C-terminal conserved region
CIB87_25170	COG4467	Involved in initiation control of chromosome replication
CIB87_25175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CIB87_25180	COG2827	Endonuclease containing a URI domain
CIB87_25185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CIB87_25190	COG2002	toxin-antitoxin pair type II binding
CIB87_25200	COG0084	hydrolase, TatD family'
CIB87_25210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CIB87_25220	COG4466	Protein conserved in bacteria
CIB87_25235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIB87_25240	COG0251	oxidation-reduction process
CIB87_25245	COG2088	sporulation resulting in formation of a cellular spore
CIB87_25250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CIB87_25255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CIB87_25260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CIB87_25265	COG0193	aminoacyl-tRNA hydrolase activity
CIB87_25275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CIB87_25280	COG2002	toxin-antitoxin pair type II binding
CIB87_25285	COG2244	polysaccharide biosynthetic process
CIB87_25290	COG3956	TIGRFAM MazG family protein
CIB87_25295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CIB87_25310	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CIB87_25315	COG1098	S1 RNA binding domain
CIB87_25335	COG2304	oxidoreductase activity
CIB87_25340	COG0515	serine threonine protein kinase
CIB87_25345	COG0037	tRNA processing
CIB87_25355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CIB87_25360	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CIB87_25365	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CIB87_25370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIB87_25375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CIB87_25380	COG0512	Glutamine amidotransferase of anthranilate synthase
CIB87_25385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CIB87_25390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CIB87_25395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CIB87_25400	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CIB87_25425	COG3880	PFAM UvrB UvrC protein
CIB87_25430	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CIB87_25435	COG0542	response to heat
CIB87_25440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CIB87_25445	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CIB87_25450	COG4956	integral membrane protein (PIN domain superfamily)
CIB87_25455	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CIB87_25465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIB87_25470	COG1045	serine acetyltransferase
CIB87_25475	COG0215	cysteine-tRNA ligase activity
CIB87_25485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CIB87_25490	COG3688	RNA-binding protein containing a PIN domain
CIB87_25500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CIB87_25505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CIB87_25510	COG0250	Participates in transcription elongation, termination and antitermination
CIB87_25520	COG0081	regulation of translation
CIB87_25525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CIB87_25535	COG2813	Specifically methylates the guanine in position
CIB87_25540	COG0085	RNA polymerase activity
CIB87_25545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CIB87_25550	COG1358	cellular component organization or biogenesis
CIB87_25555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CIB87_25560	COG0049	tRNA binding
CIB87_25570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CIB87_25575	COG0051	transcription antitermination factor activity, RNA binding
CIB87_25580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CIB87_25585	COG0088	Forms part of the polypeptide exit tunnel
CIB87_25590	COG0089	rRNA binding
CIB87_25595	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CIB87_25600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CIB87_25605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CIB87_25610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CIB87_25615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CIB87_25620	COG0255	Belongs to the universal ribosomal protein uL29 family
CIB87_25625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CIB87_25630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CIB87_25645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CIB87_25665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CIB87_25670	COG1841	ribosomal large subunit assembly
CIB87_25680	COG0201	protein transport
CIB87_25685	COG0563	adenylate kinase activity
CIB87_25690	COG0024	Methionine aminopeptidase
CIB87_25695	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CIB87_25700	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CIB87_25705	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CIB87_25715	COG0202	RNA polymerase activity
CIB87_25720	COG0203	ribosomal protein L17
CIB87_25725	COG1122	ATPase activity
CIB87_25730	COG1122	ATPase activity
CIB87_25735	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CIB87_25740	COG0101	tRNA pseudouridine synthase activity
CIB87_25745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CIB87_25760	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIB87_25765	COG0489	protein tyrosine kinase activity
CIB87_25770	COG0583	DNA-binding transcription factor activity
CIB87_25780	COG2194	sulfuric ester hydrolase activity
CIB87_25785	COG0726	polysaccharide deacetylase
CIB87_25865	COG1595	DNA-templated transcription, initiation
CIB87_25870	COG5662	AntiSigma factor
CIB87_25875	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CIB87_25885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIB87_25890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CIB87_25905	COG3103	Sh3 type 3 domain protein
CIB87_25905	COG4991	sh3 domain protein
CIB87_25905	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIB87_25910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIB87_25910	COG2213	PTS system mannitol-specific
CIB87_25915	COG3711	transcriptional antiterminator
CIB87_25920	COG0246	Mannitol dehydrogenase
CIB87_25930	COG1376	ErfK ybiS ycfS ynhG family protein
CIB87_25935	COG1970	mechanosensitive ion channel activity
CIB87_25950	COG1176	ABC-type spermidine putrescine transport system, permease component I
CIB87_25955	COG1177	transmembrane transport
CIB87_25960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CIB87_25970	COG0745	RESPONSE REGULATOR receiver
CIB87_25975	COG5002	protein histidine kinase activity
CIB87_25990	COG3976	FMN-binding domain protein
CIB87_25990	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CIB87_25995	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIB87_26000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CIB87_26005	COG0513	Belongs to the DEAD box helicase family
CIB87_26010	COG4294	response to UV
CIB87_26015	COG0705	Rhomboid family
CIB87_26020	COG0736	holo-[acyl-carrier-protein] synthase activity
CIB87_26025	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CIB87_26030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CIB87_26035	COG0864	Transcriptional regulator
CIB87_26040	COG2337	Toxic component of a toxin-antitoxin (TA) module
CIB87_26045	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_26050	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_26055	COG2172	sigma factor antagonist activity
CIB87_26060	COG2208	phosphoserine phosphatase activity
CIB87_26065	COG1366	Belongs to the anti-sigma-factor antagonist family
CIB87_26075	COG1191	sigma factor activity
CIB87_26080	COG2208	phosphoserine phosphatase activity
CIB87_26085	COG2183	response to ionizing radiation
CIB87_26180	COG0802	atpase or kinase
CIB87_26185	COG1214	PFAM Peptidase M22, glycoprotease
CIB87_26190	COG0456	acetyltransferase
CIB87_26200	COG0488	(ABC) transporter
CIB87_26205	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CIB87_26210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIB87_26215	COG0805	protein transport
CIB87_26225	COG1266	CAAX protease self-immunity
CIB87_26230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CIB87_26235	COG0459	protein refolding
CIB87_26240	COG0714	Associated with various cellular activities
CIB87_26245	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CIB87_26250	COG1305	Transglutaminase-like
CIB87_26255	COG0519	Catalyzes the synthesis of GMP from XMP
CIB87_26255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CIB87_26260	COG2252	PERMEase
CIB87_26315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CIB87_26320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CIB87_26325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CIB87_26330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CIB87_26335	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CIB87_26340	COG0047	phosphoribosylformylglycinamidine synthase activity
CIB87_26345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CIB87_26350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CIB87_26355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CIB87_26360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CIB87_26365	COG0138	bifunctional purine biosynthesis protein purh
CIB87_26370	COG0151	Belongs to the GarS family
CIB87_26380	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CIB87_26385	COG4496	protein, YerC YecD
CIB87_26390	COG0423	glycine-tRNA ligase activity
CIB87_26400	COG0210	DNA helicase
CIB87_26410	COG4851	CamS sex pheromone cAM373 precursor
CIB87_26420	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CIB87_26425	COG0154	amidase activity
CIB87_26435	COG1597	lipid kinase activity
CIB87_26450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_26460	COG0166	Belongs to the GPI family
CIB87_26465	COG1744	ABC transporter substrate-binding protein PnrA-like
CIB87_26470	COG3852	Histidine kinase
CIB87_26475	COG0024	Methionine aminopeptidase
CIB87_26480	COG2706	6-phosphogluconolactonase activity
CIB87_26490	COG4978	Transcriptional regulator
CIB87_26490	COG0789	Transcriptional regulator
CIB87_26495	COG2814	Major facilitator Superfamily
CIB87_26505	COG1876	peptidase activity
CIB87_26510	COG1126	abc transporter atp-binding protein
CIB87_26515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CIB87_26520	COG0765	amino acid transport
CIB87_26525	COG0765	amino acid transport
CIB87_26530	COG1113	amino acid transport
CIB87_26535	COG2733	membrane
CIB87_26540	COG3212	peptidase
CIB87_26545	COG3212	peptidase
CIB87_26550	COG5002	protein histidine kinase activity
CIB87_26550	COG3850	Histidine kinase
CIB87_26555	COG0745	RESPONSE REGULATOR receiver
CIB87_26560	COG2205	protein histidine kinase activity
CIB87_26565	COG0745	RESPONSE REGULATOR receiver
CIB87_26570	COG2311	Membrane
CIB87_26580	COG1131	(ABC) transporter
CIB87_26585	COG0671	phosphoesterase, PA-phosphatase related
CIB87_26590	COG1764	response to oxidative stress
CIB87_26595	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CIB87_26605	COG2259	Doxx family
CIB87_26610	COG0693	protein deglycase activity
CIB87_26630	COG5444	nuclease activity
CIB87_26655	COG2318	DinB family
CIB87_26665	COG1115	amino acid carrier protein
CIB87_26680	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CIB87_26685	COG0598	Magnesium transport protein CorA
CIB87_26690	COG3290	protein histidine kinase activity
CIB87_26695	COG4565	transcriptional regulatory protein
CIB87_26710	COG4191	Histidine kinase
CIB87_26715	COG0513	Belongs to the DEAD box helicase family
CIB87_26735	COG4842	Belongs to the WXG100 family
CIB87_26740	COG5417	Belongs to the EsaB family
CIB87_26745	COG4499	WXG100 protein secretion system (Wss), protein YukC
CIB87_26750	COG0433	COG0433 Predicted ATPase
CIB87_26750	COG1674	ftsk spoiiie
CIB87_26755	COG1511	domain protein
CIB87_26770	COG2356	endonuclease I
CIB87_26780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIB87_26795	COG0488	(ABC) transporter
CIB87_26805	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CIB87_26815	COG1959	2 iron, 2 sulfur cluster binding
CIB87_26820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CIB87_26820	COG1017	nitric oxide dioxygenase activity
CIB87_26830	COG0693	protein deglycase activity
CIB87_26835	COG2340	Cysteine-rich secretory protein family
CIB87_26840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CIB87_26845	COG4840	Belongs to the UPF0435 family
CIB87_26850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CIB87_26855	COG4980	gas vesicle protein
CIB87_26860	COG1295	ribonuclease BN
CIB87_26865	COG2217	Heavy metal translocating P-type atpase
CIB87_26875	COG0640	Transcriptional regulator
CIB87_26885	COG0477	Major facilitator Superfamily
CIB87_26895	COG3479	Phenolic acid decarboxylase
CIB87_26905	COG3871	stress protein (general stress protein 26)
CIB87_26910	COG0387	Pfam Sodium calcium exchanger
CIB87_26920	COG0535	radical SAM domain protein
CIB87_26940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CIB87_26945	COG1113	amino acid transport
CIB87_26950	COG5002	protein histidine kinase activity
CIB87_26970	COG1090	epimerase
CIB87_26980	COG4221	oxidoreductase activity
CIB87_27000	COG1988	membrane-bound metal-dependent
CIB87_27005	COG1194	a g-specific adenine glycosylase
CIB87_27015	COG1028	Short-chain dehydrogenase reductase Sdr
CIB87_27030	COG3557	Belongs to the UPF0374 family
CIB87_27035	COG1132	(ABC) transporter
CIB87_27040	COG4129	membrane
CIB87_27050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CIB87_27055	COG4555	ABC transporter
CIB87_27075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CIB87_27080	COG0735	belongs to the Fur family
CIB87_27195	COG3382	B3 4 domain protein
CIB87_27210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CIB87_27215	COG2766	serine protein kinase
CIB87_27230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CIB87_27235	COG0697	spore germination
CIB87_27260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CIB87_27270	COG1968	undecaprenyl-diphosphatase activity
CIB87_27275	COG1301	dicarboxylic acid transport
CIB87_27285	COG0586	Pfam SNARE associated Golgi protein
CIB87_27290	COG2217	Heavy metal translocating P-type atpase
CIB87_27295	COG0531	amino acid
CIB87_27315	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CIB87_27325	COG1175	transmembrane transport
CIB87_27340	COG0584	glycerophosphoryl diester phosphodiesterase
CIB87_27355	COG4948	Mandelate Racemase Muconate Lactonizing
CIB87_27400	COG3583	domain protein
CIB87_27400	COG3584	3D domain protein
CIB87_27405	COG1876	peptidase activity
CIB87_27415	COG3103	Sh3 type 3 domain protein
CIB87_27420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIB87_27420	COG0456	acetyltransferase
CIB87_27430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIB87_27455	COG1609	Transcriptional regulator
CIB87_27460	COG2814	Major facilitator Superfamily
CIB87_27465	COG0673	inositol 2-dehydrogenase activity
CIB87_27490	COG1609	Transcriptional regulator
CIB87_27505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIB87_27510	COG1522	sequence-specific DNA binding
CIB87_27540	COG1187	pseudouridine synthase activity
CIB87_27550	COG1942	4-Oxalocrotonate Tautomerase
CIB87_27555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CIB87_27570	COG2851	Citrate transporter
CIB87_27590	COG0628	permease
CIB87_27605	COG0604	alcohol dehydrogenase
CIB87_27610	COG1620	l-lactate permease
CIB87_27620	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CIB87_27625	COG0840	transmembrane signaling receptor activity
CIB87_27630	COG0564	pseudouridine synthase activity
CIB87_27640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CIB87_27655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIB87_27655	COG3153	acetyltransferase
CIB87_27660	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CIB87_27665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CIB87_27675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CIB87_27680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIB87_27685	COG1268	BioY protein
CIB87_27695	COG2719	SpoVR family
CIB87_27705	COG1959	2 iron, 2 sulfur cluster binding
CIB87_27710	COG0604	alcohol dehydrogenase
CIB87_27720	COG1126	abc transporter atp-binding protein
CIB87_27725	COG0765	amino acid transport
CIB87_27730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CIB87_27735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CIB87_27740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CIB87_27750	COG0352	thiamine-phosphate diphosphorylase activity
CIB87_27755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIB87_27770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CIB87_27775	COG0351	phosphomethylpyrimidine kinase
CIB87_27790	COG0702	epimerase
CIB87_27795	COG1253	flavin adenine dinucleotide binding
CIB87_27810	COG3842	ATPase activity
CIB87_27815	COG2508	Transcriptional regulator
CIB87_27830	COG0189	ligase activity
CIB87_27835	COG0189	ligase activity
CIB87_27845	COG3679	Belongs to the UPF0342 family
CIB87_27850	COG0561	phosphatase activity
CIB87_27855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIB87_27860	COG0318	PFAM AMP-dependent synthetase and ligase
CIB87_27865	COG1024	Enoyl-CoA hydratase
CIB87_27880	COG4152	abc transporter atp-binding protein
CIB87_27885	COG1668	transmembrane transport
CIB87_27890	COG3481	metal-dependent phosphohydrolase, HD sub domain
CIB87_27900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CIB87_27925	COG1846	Transcriptional regulator
CIB87_27940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CIB87_27945	COG1695	Transcriptional regulator
CIB87_27950	COG2153	protein acetylation
CIB87_27955	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CIB87_27955	COG2755	lipolytic protein G-D-S-L family
CIB87_27960	COG0537	adenosine 5'-monophosphoramidase activity
CIB87_27965	COG1131	(ABC) transporter
CIB87_27970	COG4473	ABC transporter
CIB87_27980	COG1473	amidohydrolase
CIB87_27985	COG0671	phosphoesterase, PA-phosphatase related
CIB87_27995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CIB87_28000	COG1396	sequence-specific DNA binding
CIB87_28135	COG0739	heme binding
CIB87_28135	COG0741	lytic transglycosylase activity
CIB87_28135	COG1196	nuclear chromosome segregation
CIB87_28175	COG0515	serine threonine protein kinase
CIB87_28175	COG2815	serine threonine protein kinase
CIB87_28220	COG1396	sequence-specific DNA binding