locus-tag class description BMWSH_0001 ENOG4105VG0 50S ribosomal protein l34 BMWSH_0002 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BMWSH_0003 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BMWSH_0005 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BMWSH_0006 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BMWSH_0008 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) BMWSH_0009 ENOG4107QJE Chromosome Partitioning Protein BMWSH_0010 ENOG4105FA0 parb-like partition protein BMWSH_0011 ENOG4108ZDA Sporulation protein YyaC BMWSH_0013 ENOG4105D8X mechanosensitive ion channel BMWSH_0014 ENOG4105VDK protein, conserved in bacteria BMWSH_0015 ENOG4105C3G gtp-binding protein BMWSH_0017 ENOG4108UUM single-stranded DNA-binding protein BMWSH_0018 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BMWSH_0020 ENOG4105BZR domain protein BMWSH_0022 ENOG4105CDU Replicative dna helicase BMWSH_0023 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BMWSH_0024 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMWSH_0025 ENOG4105BZU Histidine kinase BMWSH_0028 ENOG4105Q2H domain protein BMWSH_0029 ENOG4105C0H protease BMWSH_0031 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BMWSH_0034 ENOG4105DR4 Methyltransferase BMWSH_0035 ENOG4107QPK )-transporter BMWSH_0045 ENOG4105ETE Transcriptional regulator (LacI family BMWSH_0046 ENOG4105DWK Membrane BMWSH_0047 ENOG4107XM3 UPF0442 protein BMWSH_0048 ENOG4105C4M (Ubiquinol oxidase) subunit I BMWSH_0049 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BMWSH_0050 ENOG4108JJ9 ABC, transporter BMWSH_0051 ENOG4108JJ8 (ABC) transporter BMWSH_0054 ENOG4105CJR Integral membrane protein (MviN BMWSH_0056 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BMWSH_0058 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 BMWSH_0059 ENOG4105CPK Glycosyl transferase (Group 1 BMWSH_0061 ENOG4105CI1 PTS System BMWSH_0062 ENOG4107URF beta-phospho-glucomutase BMWSH_0063 ENOG4105J7I hydrolase BMWSH_0064 ENOG4105DWF phosphomethylpyrimidine kinase BMWSH_0066 ENOG4105DCF alanine dehydrogenase BMWSH_0067 ENOG4108K8K Transcriptional regulator BMWSH_0068 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BMWSH_0069 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BMWSH_0071 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BMWSH_0075 ENOG4108VKI Cell wall hydrolase BMWSH_0076 ENOG4107JTW chlorite dismutase BMWSH_0077 ENOG4108IJ2 phosphate acetyltransferase BMWSH_0080 ENOG4108VCI transcription factor, rsfa family BMWSH_0083 ENOG4105DCI Phosphohydrolase BMWSH_0085 ENOG41069HH 4-oxalocrotonate tautomerase BMWSH_0086 ENOG4108Z4T Peptidase M50 BMWSH_0087 ENOG4108XFG YwhD family BMWSH_0088 ENOG4105BZ4 penicillin-binding protein BMWSH_0089 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BMWSH_0090 ENOG4105CYW agmatinase BMWSH_0091 ENOG410684U Domain of unknown function (DUF1934) BMWSH_0092 ENOG4105C75 arginyL-tRNA synthetase BMWSH_0095 ENOG4105DF6 Fe-S oxidoreductase BMWSH_0097 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BMWSH_0098 ENOG4105C1G acyl-Coa dehydrogenase BMWSH_0099 ENOG4105C1G acyl-Coa dehydrogenase BMWSH_0101 ENOG4105D5P Methylmalonyl-coA mutase BMWSH_0103 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BMWSH_0105 ENOG410812K response regulator receiver protein BMWSH_0106 ENOG4105D2N Aldolase BMWSH_0107 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BMWSH_0108 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BMWSH_0109 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BMWSH_0110 ENOG4105VFB Binds the 23S rRNA (By similarity) BMWSH_0112 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BMWSH_0113 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BMWSH_0114 ENOG4108ZXQ stage ii sporulation protein r BMWSH_0116 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BMWSH_0119 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BMWSH_0120 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BMWSH_0121 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BMWSH_0123 ENOG41062M3 atp synthase BMWSH_0124 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BMWSH_0125 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BMWSH_0126 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) BMWSH_0127 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BMWSH_0128 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BMWSH_0129 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BMWSH_0130 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BMWSH_0131 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BMWSH_0132 ENOG4106778 Protein of unknown function (DUF1146) BMWSH_0136 ENOG4105FRN stage II sporulation protein BMWSH_0137 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BMWSH_0138 ENOG4105DFF Rod shape-determining protein mreb BMWSH_0140 ENOG4105CGA flagellar basal-body rod protein FlgG BMWSH_0141 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BMWSH_0144 ENOG4105Z8H single-stranded DNA-binding protein BMWSH_0146 ENOG4105C0D helicase BMWSH_0148 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BMWSH_0151 ENOG4105DZ6 Band 7 protein BMWSH_0153 ENOG4105ESV Glycosyl transferase, family 4 BMWSH_0154 ENOG4108KGH TRANSCRIPTIONal BMWSH_0155 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BMWSH_0156 ENOG4105BZU Histidine kinase BMWSH_0157 ENOG4105WH1 Two component transcriptional regulator luxr family BMWSH_0159 ENOG4105XVJ Protein of unknown function (DUF327) BMWSH_0162 ENOG41081UC Inherit from COG: Competence protein BMWSH_0166 ENOG4105E1Q flagellar hook-associated protein BMWSH_0167 ENOG4105DTJ flagellar hook-associated protein BMWSH_0168 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BMWSH_0169 ENOG4105TRT Transcriptional regulator BMWSH_0170 ENOG4108JB8 alcohol dehydrogenase BMWSH_0171 ENOG4105C26 Dehydrogenase BMWSH_0173 ENOG4105C85 amino acid BMWSH_0175 ENOG4107RT6 flagellar hook-associated BMWSH_0176 ENOG4105MQ3 flagellar protein FliS BMWSH_0178 ENOG4105MS2 ribosomal subunit Interface protein BMWSH_0179 ENOG4105SUU thioesterase domain BMWSH_0180 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BMWSH_0181 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BMWSH_0183 ENOG4105DGI Alkaline phosphatase BMWSH_0184 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BMWSH_0185 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BMWSH_0187 ENOG4108WS4 fmn reductase BMWSH_0188 ENOG4105CAK Cell division ATP-binding protein ftsE BMWSH_0189 ENOG4105CRP Part of the ABC transporter FtsEX involved in BMWSH_0190 ENOG4105DR5 peptidase BMWSH_0191 ENOG4105CN1 protease BMWSH_0195 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BMWSH_0196 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BMWSH_0197 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BMWSH_0199 ENOG4108PY7 BMWSH_0201 ENOG41086DT Membrane protein of unknown function BMWSH_0202 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BMWSH_0203 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BMWSH_0204 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BMWSH_0205 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BMWSH_0206 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BMWSH_0207 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BMWSH_0208 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BMWSH_0209 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BMWSH_0210 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BMWSH_0211 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BMWSH_0213 ENOG4105C3M thioredoxin reductase BMWSH_0214 ENOG4108Z4K mutator MutT protein BMWSH_0215 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BMWSH_0216 ENOG4105CHW UPF0052 protein BMWSH_0218 ENOG4105KRI phosphocarrier protein (HPr BMWSH_0219 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BMWSH_0221 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMWSH_0229 ENOG4105XZU Preprotein translocase, subunit SecG BMWSH_0231 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BMWSH_0232 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BMWSH_0233 ENOG4105E0C molybdate abc transporter BMWSH_0234 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BMWSH_0236 ENOG4108JB9 formate dehydrogenase BMWSH_0237 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BMWSH_0238 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BMWSH_0240 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BMWSH_0241 ENOG4105D06 uba thif-type nad fad binding protein BMWSH_0242 ENOG4105CVM Molybdenum cofactor synthesis domain protein BMWSH_0243 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BMWSH_0244 ENOG4105FS7 Transcriptional regulator BMWSH_0245 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BMWSH_0247 ENOG41062D9 Histidine kinase BMWSH_0250 ENOG4105CMU LysR family (Transcriptional regulator BMWSH_0251 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BMWSH_0252 ENOG41079KZ Major Facilitator Superfamily BMWSH_0253 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BMWSH_0255 ENOG41067SE Tetr family transcriptional regulator BMWSH_0259 ENOG4108MES Periplasmic binding protein BMWSH_0260 ENOG4105DQ5 transport system permease protein BMWSH_0261 ENOG4108IHU transport system permease protein BMWSH_0262 ENOG4105E0A ABC, transporter BMWSH_0268 ENOG4105CHU acetyl-coa acetyltransferase BMWSH_0269 ENOG4105C1G acyl-Coa dehydrogenase BMWSH_0270 ENOG41080E8 Transcriptional regulator, Spx MgsR family BMWSH_0271 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BMWSH_0275 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BMWSH_0276 ENOG4108UMI ABC transporter, permease BMWSH_0277 ENOG4105D01 (LipO)protein BMWSH_0279 ENOG4105C3K feS assembly ATPase SufC BMWSH_0280 ENOG4105JRK feS assembly protein SufD BMWSH_0281 ENOG4105C9B Cysteine desulfurase BMWSH_0282 ENOG4108UNV SUF system FeS assembly protein, NifU family BMWSH_0283 ENOG4105DIW FeS assembly protein SUFB BMWSH_0284 ENOG4105I3N Conserved Protein BMWSH_0285 ENOG4105KZD Domain of unknown function (DUF1805) BMWSH_0287 ENOG4105C8J )-transporter BMWSH_0289 ENOG4105FAA peptidase M23 BMWSH_0290 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BMWSH_0291 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BMWSH_0292 ENOG4105MMD transcriptional regulator BMWSH_0295 ENOG4105D4U had-superfamily hydrolase, subfamily iia BMWSH_0296 ENOG4108W5N phosphatidylglycerophosphatase a BMWSH_0298 ENOG4105C5I Dehydrogenase BMWSH_0299 ENOG4105D6E homoserine dehydrogenase BMWSH_0300 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BMWSH_0301 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BMWSH_0302 ENOG41083MR nifu domain-containing protein BMWSH_0305 ENOG4105ZKE UPF0349 protein BMWSH_0308 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BMWSH_0311 ENOG4105CEP NADH dehydrogenase BMWSH_0313 ENOG41069ER domain protein BMWSH_0315 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BMWSH_0320 ENOG4105KA0 thioesterase Superfamily protein BMWSH_0322 ENOG4105Y38 Kinase-associated protein B BMWSH_0324 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BMWSH_0325 ENOG4105C87 Aminotransferase class I and II BMWSH_0326 ENOG4108MUZ hydrolase BMWSH_0327 ENOG4108ZB6 transcriptional regulator AsnC family BMWSH_0328 ENOG4105CHM Aminotransferase BMWSH_0330 ENOG4105WG9 Conserved Protein BMWSH_0331 ENOG4107QW4 alcohol dehydrogenase BMWSH_0332 ENOG4105KJM monovalent cation h antiporter subunit g BMWSH_0334 ENOG4105D65 subunit l BMWSH_0336 ENOG4107QYV phosphohexose isomerase BMWSH_0338 ENOG4107PBV potassium channel BMWSH_0344 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BMWSH_0345 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BMWSH_0346 ENOG4105CEY Amp-dependent synthetase and ligase BMWSH_0350 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BMWSH_0354 ENOG4105E4F Isochorismate synthase BMWSH_0355 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BMWSH_0356 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BMWSH_0357 ENOG4108IPT Naphthoate synthase BMWSH_0358 ENOG4105CEY Amp-dependent synthetase and ligase BMWSH_0359 ENOG4105DTQ mandelate racemase muconate lactonizing BMWSH_0360 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BMWSH_0361 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BMWSH_0366 ENOG4105NQC Flavodoxin BMWSH_0369 ENOG4105NRA 50s ribosomal protein l31 type b BMWSH_0371 ENOG4105CKI cobalamin synthesis protein BMWSH_0372 ENOG4108V2W Carbonate dehydratase BMWSH_0373 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BMWSH_0374 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BMWSH_0375 ENOG4108RMU ferritin dps family protein BMWSH_0379 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BMWSH_0381 ENOG4105D2X ABC transporter substrate-binding protein BMWSH_0384 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BMWSH_0385 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BMWSH_0386 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BMWSH_0387 ENOG4105BZF Glycosyl transferase (Group 1 BMWSH_0388 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BMWSH_0389 ENOG4108Z0R Transferase BMWSH_0390 ENOG4105E8V Alpha Beta Hydrolase Fold protein BMWSH_0393 ENOG4105N5T Radical SAM Protein BMWSH_0396 ENOG410605W Major Facilitator BMWSH_0397 ENOG4105CY2 Citrate transporter BMWSH_0399 ENOG4105C8T Leucyl-tRNA synthetase BMWSH_0400 ENOG41085GJ domain protein BMWSH_0402 ENOG4105CBX hi0933 family BMWSH_0405 ENOG4105YW5 deoR family transcriptional regulator BMWSH_0406 ENOG4107QSE Dipeptidase BMWSH_0407 ENOG4105C6T cysteine synthase BMWSH_0408 ENOG4107F58 2'-5' rna ligase BMWSH_0410 ENOG4108IUM Glycogen debranching enzyme BMWSH_0411 ENOG4108V15 phosphotransferase enzyme family BMWSH_0413 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BMWSH_0414 ENOG4105C8F Beta-lactamase domain protein BMWSH_0417 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BMWSH_0419 ENOG4108NKM UPF0354 protein BMWSH_0420 ENOG4108VDD TRNA binding domain protein BMWSH_0423 ENOG4105DFU Cell wall formation (By similarity) BMWSH_0428 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BMWSH_0430 ENOG4105ETE Transcriptional regulator (LacI family BMWSH_0431 ENOG4105E14 MotA TolQ exbB proton channel BMWSH_0432 ENOG4106VK6 Flagellar motor protein BMWSH_0433 ENOG4105DGU Histone deacetylase BMWSH_0434 ENOG4105W87 Cbs domain BMWSH_0435 ENOG4105F1V Acetoin utilization protein BMWSH_0437 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BMWSH_0438 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BMWSH_0441 ENOG4105U5Y Transcriptional regulator BMWSH_0442 ENOG4108W76 histidinol phosphate phosphatase hisj family BMWSH_0443 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) BMWSH_0446 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BMWSH_0448 ENOG4105EFZ amidohydrolase BMWSH_0449 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BMWSH_0450 ENOG4105D07 Signal peptide peptidase, SppA BMWSH_0451 ENOG4105VK3 rdd domain containing protein BMWSH_0453 ENOG4105KBJ sporulation protein ytfj BMWSH_0454 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BMWSH_0456 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BMWSH_0459 ENOG4105CDH Citrulline--aspartate ligase BMWSH_0460 ENOG4105CH7 arginosuccinase BMWSH_0463 ENOG4105E8R UPF0173 metal-dependent hydrolase BMWSH_0468 ENOG4105SFS phosphoesterase RecJ domain protein BMWSH_0470 ENOG4105VV2 BMWSH_0471 ENOG4105C0B DNA polymerase III (alpha subunit) BMWSH_0472 ENOG4105C6K Malic enzyme BMWSH_0473 ENOG4107YCY Transcriptional regulator BMWSH_0474 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BMWSH_0475 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BMWSH_0476 ENOG4105CA9 Pyruvate kinase BMWSH_0477 ENOG4105FS0 cytoplasmic membrane protein BMWSH_0478 ENOG4108REF Sporulation integral membrane protein ytvi BMWSH_0479 ENOG4107CWS Protein of unknown function (DUF441) BMWSH_0481 ENOG4105BZN citrate synthase BMWSH_0482 ENOG4108HMX isocitrate dehydrogenase (NADP) BMWSH_0483 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BMWSH_0485 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BMWSH_0486 ENOG4105BZU Histidine kinase BMWSH_0487 ENOG4105C2M dna polymerase I BMWSH_0491 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BMWSH_0492 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BMWSH_0494 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BMWSH_0497 ENOG4108TDW sporulation protein YtxC BMWSH_0498 ENOG4105C22 threonyL-tRNA synthetase BMWSH_0499 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BMWSH_0500 ENOG4105VJV 50s ribosomal protein L35 BMWSH_0501 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BMWSH_0505 ENOG4105CN9 Peptidase m42 family protein BMWSH_0506 ENOG41067MF small acid-soluble spore protein BMWSH_0507 ENOG4108RWN rrna methyltransferase BMWSH_0508 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BMWSH_0509 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BMWSH_0510 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BMWSH_0511 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BMWSH_0513 ENOG4105DCG PHP domain protein BMWSH_0514 ENOG4105C98 muts2 protein BMWSH_0517 ENOG4105CEY Amp-dependent synthetase and ligase BMWSH_0518 ENOG4107Z3H Transcriptional regulator, TetR family BMWSH_0519 ENOG41060WC Enoyl-CoA hydratase BMWSH_0520 ENOG4105BZJ Electron transfer flavoprotein BMWSH_0521 ENOG4105C10 Electron transfer flavoprotein BMWSH_0522 ENOG4105K63 Thioredoxin BMWSH_0524 ENOG4105CFH Aspartokinase BMWSH_0526 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BMWSH_0528 ENOG4105E33 succinate dehydrogenase BMWSH_0531 ENOG4105PFC Transcriptional regulator BMWSH_0533 ENOG4105NCW Trka-c domain protein BMWSH_0534 ENOG4107S91 Sodium hydrogen exchanger BMWSH_0535 ENOG4105E2Y ABC, transporter BMWSH_0536 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BMWSH_0537 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BMWSH_0538 ENOG4108UZX fmn reductase BMWSH_0539 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BMWSH_0541 ENOG4107RVG penicillin-binding protein BMWSH_0542 ENOG4107GRR phosphate transport regulator BMWSH_0543 ENOG4105CJ3 phosphate transporter BMWSH_0544 ENOG4108QCI YvbH-like oligomerisation region BMWSH_0545 ENOG41067TZ transcriptional regulator, MarR family BMWSH_0546 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BMWSH_0547 ENOG4108XJQ germination protein BMWSH_0550 ENOG4105M59 Phosphodiesterase, mj0936 family BMWSH_0551 ENOG4105C7K acetolactate synthase BMWSH_0552 ENOG4108ZP8 Acetolactate synthase small subunit BMWSH_0553 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BMWSH_0554 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BMWSH_0556 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BMWSH_0557 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BMWSH_0559 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BMWSH_0560 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BMWSH_0561 ENOG4108IUQ atp-dependent protease BMWSH_0562 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BMWSH_0563 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BMWSH_0565 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BMWSH_0567 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BMWSH_0569 ENOG4105D52 delta-aminolevulinic acid dehydratase BMWSH_0570 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BMWSH_0571 ENOG41068KH stage VI sporulation protein D BMWSH_0572 ENOG4106AR7 Spore coat protein BMWSH_0574 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BMWSH_0575 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BMWSH_0576 ENOG4108SJC Membrane BMWSH_0578 ENOG4106A3R peptidase BMWSH_0580 ENOG4108Z03 MAF-like protein BMWSH_0581 ENOG4105W5Q DNA repair protein (RadC BMWSH_0582 ENOG4105DFF Rod shape-determining protein mreb BMWSH_0583 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BMWSH_0584 ENOG4105YHC Rod shape-determining protein MreD BMWSH_0585 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BMWSH_0586 ENOG4107QMS site-determining protein BMWSH_0589 ENOG4105C03 ribonuclease BMWSH_0591 ENOG4105X36 (ribosomal) protein BMWSH_0592 ENOG4105K46 50S ribosomal protein l27 BMWSH_0594 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BMWSH_0595 ENOG41090I5 UPF0735 ACT domain-containing protein BMWSH_0596 ENOG4105CQC Prephenate dehydratase BMWSH_0599 ENOG4108IYU L-aspartate oxidase BMWSH_0600 ENOG4106678 morphogenetic protein associated with SpoVID BMWSH_0605 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BMWSH_0606 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BMWSH_0607 ENOG4105VIE preprotein translocase, subunit YajC BMWSH_0608 ENOG4105NAP BMWSH_0609 ENOG4108QG2 Membrane BMWSH_0610 ENOG4105CKP Polysaccharide Biosynthesis Protein BMWSH_0612 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BMWSH_0613 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BMWSH_0614 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BMWSH_0615 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BMWSH_0616 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BMWSH_0617 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BMWSH_0619 ENOG4105CUT histidyl-tRNA synthetase BMWSH_0620 ENOG4105C9M aspartyl-trna synthetase BMWSH_0621 ENOG4105CUZ uba thif-type nad fad binding protein BMWSH_0622 ENOG4105CVA phosphate BMWSH_0623 ENOG4105C8U phosphate abc transporter BMWSH_0624 ENOG4105E2Z phosphate ABC transporter (Permease BMWSH_0625 ENOG4105D1H recombination factor protein RarA BMWSH_0627 ENOG4105C3J Cysteine desulfurase BMWSH_0628 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BMWSH_0630 ENOG4105C7H Helicase, RecD TraA family BMWSH_0631 ENOG41060CR BMWSH_0633 ENOG4105C02 permease BMWSH_0635 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BMWSH_0636 ENOG4105VBH UPF0297 protein BMWSH_0638 ENOG4105VPH UPF0473 protein BMWSH_0639 ENOG4105HHA aminodeoxychorismate lyase BMWSH_0640 ENOG4108VQJ O-methyltransferase BMWSH_0641 ENOG4105XYU peptidase (U32 family) BMWSH_0642 ENOG4105CFP Peptidase U32 BMWSH_0643 ENOG4105DBI uridine monophosphokinase BMWSH_0644 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BMWSH_0645 ENOG4105D3W isochorismatase BMWSH_0646 ENOG4107XRG penicillin-binding protein BMWSH_0649 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BMWSH_0652 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMWSH_0654 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BMWSH_0655 ENOG4105DJ4 phosphatidylserine decarboxylase BMWSH_0657 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BMWSH_0658 ENOG4105CQW ribosome biogenesis GTPase YqeH BMWSH_0659 ENOG4108WF2 Metal Dependent Phosphohydrolase BMWSH_0660 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BMWSH_0661 ENOG4105DXX methyltransferase BMWSH_0663 ENOG4105KQC Competence protein BMWSH_0664 ENOG4108UK2 deaminase BMWSH_0665 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BMWSH_0667 ENOG4105TQK DNA polymerase iii, delta' subunit BMWSH_0668 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BMWSH_0671 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BMWSH_0672 ENOG4105CSA Coproporphyrinogen iii oxidase BMWSH_0673 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BMWSH_0674 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BMWSH_0676 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BMWSH_0677 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BMWSH_0678 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BMWSH_0679 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BMWSH_0681 ENOG4105KTH gatB Yqey BMWSH_0682 ENOG4105F7J membrane-bound serine protease BMWSH_0685 ENOG41068P3 sporulation protein YqfC BMWSH_0687 ENOG4105C9A Phoh family BMWSH_0688 ENOG4105CTJ Metal Dependent Phosphohydrolase BMWSH_0689 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BMWSH_0690 ENOG4107YR5 Diacylglycerol kinase BMWSH_0691 ENOG4105KG3 cytidine deaminase BMWSH_0692 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BMWSH_0694 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BMWSH_0696 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BMWSH_0697 ENOG4107XJU UPF0178 protein BMWSH_0698 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BMWSH_0699 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMWSH_0700 ENOG4105C1G acyl-Coa dehydrogenase BMWSH_0703 ENOG4105EGD dinuclear metal center protein, YbgI family BMWSH_0704 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BMWSH_0707 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BMWSH_0709 ENOG4105FDK ABC transporter BMWSH_0710 ENOG4105FAV ABC, transporter BMWSH_0711 ENOG4105N80 Ferric uptake regulator, Fur family BMWSH_0712 ENOG4108U5J '-nucleotidase BMWSH_0713 ENOG41063Y9 BMWSH_0714 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BMWSH_0716 ENOG4107RCC Major Facilitator Superfamily BMWSH_0717 ENOG4107RCC Major Facilitator Superfamily BMWSH_0719 ENOG4105SXS Protein of unknown function (DUF456) BMWSH_0722 ENOG4107RF6 penicillin-binding protein BMWSH_0723 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BMWSH_0724 ENOG4108UTW Plays a role in the regulation of phosphate uptake BMWSH_0728 ENOG410861F 50S ribosomal protein L33 BMWSH_0729 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BMWSH_0732 ENOG4107ZXI Rhomboid family BMWSH_0734 ENOG4105DKQ ROK family BMWSH_0738 ENOG4105C5X domain protein BMWSH_0744 ENOG4106855 Competence protein BMWSH_0751 ENOG4105C0D helicase BMWSH_0752 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BMWSH_0753 ENOG4105WZW rhodanese family BMWSH_0754 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BMWSH_0757 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BMWSH_0758 ENOG4105KST dependent repressor BMWSH_0761 ENOG4105CBJ Metal-dependent enzyme BMWSH_0763 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BMWSH_0764 ENOG4105CD2 stage iii sporulation protein aa BMWSH_0765 ENOG4105KR5 Stage iii sporulation protein BMWSH_0766 ENOG4108CQH stage III sporulation protein AC BMWSH_0767 ENOG4105KQ4 Stage iii sporulation protein ad BMWSH_0769 ENOG410644B Stage III sporulation protein af BMWSH_0774 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BMWSH_0775 ENOG4108ZSR alkaline shock protein BMWSH_0776 ENOG4105M7K Involved in the transcription termination process (By similarity) BMWSH_0778 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BMWSH_0781 ENOG4105DX0 Hemolysin A BMWSH_0783 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BMWSH_0784 ENOG4105S1Z Stage IV sporulation protein B BMWSH_0785 ENOG4107QQR Sporulation BMWSH_0787 ENOG4105DUX Transporter BMWSH_0789 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BMWSH_0790 ENOG4106CCJ Protein of unknown function (DUF2627) BMWSH_0791 ENOG4108JUB Transcriptional regulator BMWSH_0793 ENOG4107RDP Dehydrogenase BMWSH_0797 ENOG4105CPP Dehydrogenase, E1 component BMWSH_0798 ENOG4105C7S Dehydrogenase BMWSH_0799 ENOG4105C7S Dehydrogenase BMWSH_0801 ENOG4105D5P Methylmalonyl-coA mutase BMWSH_0802 ENOG4105DJT lAO AO transport system ATPase BMWSH_0803 ENOG4108Y6J UPF0403 protein BMWSH_0804 ENOG4108HW3 (ABC) transporter BMWSH_0805 ENOG4108QEG Membrane BMWSH_0806 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BMWSH_0808 ENOG4108HNZ carboxyl transferase BMWSH_0809 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BMWSH_0810 ENOG4105BZ8 glutamate synthase BMWSH_0813 ENOG4105G9B Transcriptional regulator BMWSH_0814 ENOG4105C26 Dehydrogenase BMWSH_0815 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BMWSH_0816 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BMWSH_0817 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BMWSH_0818 ENOG4105II7 pyrroline-5-carboxylate reductase BMWSH_0819 ENOG41069FQ Metallo-beta-lactamase superfamily BMWSH_0820 ENOG4108IXY short-chain dehydrogenase reductase BMWSH_0824 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BMWSH_0825 ENOG4105CHU acetyl-coa acetyltransferase BMWSH_0826 ENOG4105D6N CoA-transferase, subunit a BMWSH_0827 ENOG4108IIH CoA-transferase subunit B BMWSH_0829 ENOG4105CPC Aldo Keto reductase BMWSH_0831 ENOG4108YZ4 nudix hydrolase BMWSH_0832 ENOG4105MZ9 stage II sporulation protein m BMWSH_0833 ENOG4105I3K Ferric uptake regulator, Fur family BMWSH_0835 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BMWSH_0838 ENOG4105DZ1 carboxypeptidase BMWSH_0839 ENOG41082AN stage II sporulation protein BMWSH_0840 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BMWSH_0841 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMWSH_0844 ENOG41090VF Stage v sporulation protein ac BMWSH_0845 ENOG4105CZ3 stage V sporulation protein ad BMWSH_0847 ENOG4105G6R Stage v sporulation protein ae BMWSH_0850 ENOG4105PTM secreted protein BMWSH_0851 ENOG4107ZE5 PPIases accelerate the folding of proteins BMWSH_0855 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BMWSH_0856 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BMWSH_0857 ENOG4105DZ1 carboxypeptidase BMWSH_0858 ENOG4108JIC nucleoside recognition domain protein BMWSH_0859 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BMWSH_0860 ENOG4107TWT Cytochrome c biogenesis protein BMWSH_0861 ENOG4105CRE cytochrome C BMWSH_0863 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMWSH_0864 ENOG4105BZU Histidine kinase BMWSH_0865 ENOG4105DR5 peptidase BMWSH_0866 ENOG4108JQ1 Dehydrogenase BMWSH_0868 ENOG4108SAX Membrane BMWSH_0871 ENOG4105C9U ATP-dependent DNA helicase RecQ BMWSH_0872 ENOG4105I7S Abortive infection protein BMWSH_0875 ENOG4107RGJ metallophosphoesterase BMWSH_0876 ENOG4108XDN Transcriptional regulator BMWSH_0877 ENOG4108S6Z Negative regulator of genetic competence BMWSH_0879 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BMWSH_0880 ENOG4107RB3 L-asparaginase BMWSH_0882 ENOG4105F0V Cell wall hydrolase BMWSH_0883 ENOG4105MSI germination protein ypeb BMWSH_0886 ENOG4105CAT Cytidine monophosphate kinase BMWSH_0887 ENOG4105E9Q Acyl-transferase BMWSH_0888 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BMWSH_0889 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BMWSH_0890 ENOG4105DJB Major Facilitator Superfamily BMWSH_0894 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BMWSH_0898 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BMWSH_0899 ENOG4105K70 DNA-binding protein BMWSH_0900 ENOG4105EUJ GTP cyclohydrolase i BMWSH_0901 ENOG4105WP2 Tryptophan RNA-binding attenuator protein BMWSH_0902 ENOG4105XXQ heptaprenyl diphosphate synthase component I BMWSH_0903 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BMWSH_0904 ENOG4105EAH synthase BMWSH_0905 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BMWSH_0906 ENOG4105BZU Histidine kinase BMWSH_0907 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BMWSH_0908 ENOG4105D49 3-dehydroquinate synthase BMWSH_0910 ENOG4108I0Q anthranilate phosphoribosyltransferase BMWSH_0911 ENOG4105DK0 Indole-3-glycerol phosphate synthase BMWSH_0912 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BMWSH_0913 ENOG4105CIH Imidazole acetol-phosphate transaminase BMWSH_0915 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BMWSH_0916 ENOG41068YB TPR repeat-containing protein BMWSH_0917 ENOG4108SXZ UPF0302 protein BMWSH_0919 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BMWSH_0920 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BMWSH_0926 ENOG4105WUC UPF0298 protein BMWSH_0928 ENOG4106H78 methyltransferase BMWSH_0929 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BMWSH_0930 ENOG4105H20 Sporulation integral membrane protein YlbJ BMWSH_0931 ENOG4105D78 K07001 NTE family protein BMWSH_0932 ENOG41063PX domain protein BMWSH_0933 ENOG4105CDE UPF0348 protein BMWSH_0934 ENOG4105KNH Nucleic acid-binding protein BMWSH_0935 ENOG41067VY 50S ribosomal protein L32 BMWSH_0936 ENOG4105E39 Enoyl-CoA hydratase BMWSH_0938 ENOG4108YG3 N-acetyltransferase BMWSH_0939 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BMWSH_0942 ENOG41074B2 UPF0747 protein BMWSH_0944 ENOG41068DC Essential cell division protein (By similarity) BMWSH_0945 ENOG4105CJN penicillin-binding protein BMWSH_0946 ENOG4105CJN penicillin-binding protein BMWSH_0947 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BMWSH_0948 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BMWSH_0949 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BMWSH_0950 ENOG4105CNI cell division protein FtsW BMWSH_0952 ENOG4105D4A Cell wall formation (By similarity) BMWSH_0953 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BMWSH_0954 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BMWSH_0955 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BMWSH_0956 ENOG4108AWX Sporulation factor SpoIIGA BMWSH_0957 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMWSH_0959 ENOG4105WR5 sporulation protein, YlmC YmxH family BMWSH_0960 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BMWSH_0961 ENOG4105DFA alanine racemase domain protein BMWSH_0962 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BMWSH_0963 ENOG41067XK integral membrane protein BMWSH_0964 ENOG4105DBK s4 domain protein BMWSH_0968 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BMWSH_0969 ENOG4105C34 Pseudouridine synthase BMWSH_0971 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BMWSH_0973 ENOG4105CXT aspartate transcarbamylase BMWSH_0974 ENOG4105CD3 dihydroorotase BMWSH_0977 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BMWSH_0980 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BMWSH_0981 ENOG4105F23 Fibronectin-binding protein BMWSH_0983 ENOG4105DSJ YicC domain protein BMWSH_0984 ENOG4105KC4 UPF0296 protein BMWSH_0985 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BMWSH_0987 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BMWSH_0988 ENOG4105C25 Primosomal protein n' BMWSH_0990 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BMWSH_0991 ENOG4108ZF3 Phosphatase BMWSH_0992 ENOG4105D9P serine threonine protein kinase BMWSH_0993 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BMWSH_0994 ENOG4105DJV ribulose-phosphate 3-epimerase BMWSH_0996 ENOG4105FJ0 thiamine BMWSH_0997 ENOG4105VB9 50S ribosomal protein l28 BMWSH_0998 ENOG4108ZAA Alkaline-shock protein BMWSH_0999 ENOG4105DP4 dak2 domain fusion protein ylov BMWSH_1002 ENOG4105EJQ L-serine dehydratase BMWSH_1003 ENOG4105CB5 ATP-dependent DNA helicase recG BMWSH_1004 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BMWSH_1005 ENOG4105CHR reductase BMWSH_1006 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BMWSH_1007 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BMWSH_1008 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BMWSH_1009 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BMWSH_1010 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BMWSH_1012 ENOG4105K5M 30s ribosomal protein S16 BMWSH_1013 ENOG4105VB6 UPF0109 protein BMWSH_1015 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BMWSH_1017 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BMWSH_1021 ENOG4105CMV Succinyl-CoA synthetase subunit beta BMWSH_1022 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BMWSH_1023 ENOG4105C79 DNA protecting protein DprA BMWSH_1024 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BMWSH_1025 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BMWSH_1026 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BMWSH_1027 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BMWSH_1028 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BMWSH_1029 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) BMWSH_1031 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BMWSH_1032 ENOG4108ZC9 flagellar basal-body rod protein flgc BMWSH_1033 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BMWSH_1034 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BMWSH_1035 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BMWSH_1038 ENOG4106YF4 Flagellar biosynthesis chaperone BMWSH_1041 ENOG410822I Flagellar hook capping protein BMWSH_1042 ENOG4108JQA flagellar BMWSH_1043 ENOG41068WV flagellar FlbD family protein BMWSH_1045 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BMWSH_1046 ENOG4105DD5 Flagellar motor switch protein BMWSH_1047 ENOG4107YTP response regulator receiver protein BMWSH_1049 ENOG4105CN7 Flagellar biosynthetic protein FliP BMWSH_1050 ENOG4105VS8 Flagellar biosynthetic protein fliq BMWSH_1051 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BMWSH_1052 ENOG4105D00 flagellar biosynthetic protein flhB BMWSH_1053 ENOG4105D7B Flagellar biosynthesis protein flha BMWSH_1054 ENOG4105FZW flagellar biosynthesis regulator FlhF BMWSH_1056 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BMWSH_1057 ENOG4105CBS Chea signal transduction histidine kinase BMWSH_1058 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BMWSH_1059 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BMWSH_1060 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMWSH_1062 ENOG4105CE9 30S ribosomal protein S2 BMWSH_1063 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BMWSH_1065 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BMWSH_1066 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BMWSH_1067 ENOG4105KNE Phosphatidate cytidylyltransferase BMWSH_1068 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BMWSH_1069 ENOG4105DZP Membrane-associated zinc metalloprotease BMWSH_1070 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BMWSH_1071 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BMWSH_1072 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BMWSH_1073 ENOG4105CHV Transcription elongation factor NusA BMWSH_1074 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BMWSH_1075 ENOG4105VHM ribosomal protein BMWSH_1076 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BMWSH_1077 ENOG4105W7A Protein of unknown function (DUF503) BMWSH_1080 ENOG4105DTN riboflavin biosynthesis protein ribF BMWSH_1081 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BMWSH_1082 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BMWSH_1084 ENOG4105C1V Peptidase, M16 BMWSH_1086 ENOG4105E35 Dipicolinate synthase subunit A BMWSH_1087 ENOG4108S0H Dipicolinic acid synthetase, b subunit BMWSH_1088 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BMWSH_1090 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BMWSH_1092 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BMWSH_1094 ENOG4105CNU cell division protein FtsK BMWSH_1095 ENOG4105FDP GntR family transcriptional regulator BMWSH_1096 ENOG4105DIH basic membrane BMWSH_1097 ENOG4108JQ9 ABC transporter BMWSH_1098 ENOG4105UIB (ABC) transporter BMWSH_1100 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BMWSH_1101 ENOG4105XZV Protein of unknown function (DUF3243) BMWSH_1105 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BMWSH_1106 ENOG4105CEV competence damage-inducible protein BMWSH_1107 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BMWSH_1109 ENOG4105D48 metallophosphoesterase BMWSH_1110 ENOG4105MCT stage V sporulation protein S BMWSH_1114 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BMWSH_1115 ENOG4105DQU oxidoreductase, subunit beta BMWSH_1116 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BMWSH_1119 ENOG4105CUB amino acid BMWSH_1120 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BMWSH_1121 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BMWSH_1122 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BMWSH_1124 ENOG4106F1P AAA ATPase, central domain protein BMWSH_1125 ENOG4105EN6 Membrane BMWSH_1126 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BMWSH_1127 ENOG4105CXI aluminum resistance protein BMWSH_1128 ENOG4105KV4 Transcriptional regulator BMWSH_1129 ENOG4105C5F glutamine synthetase BMWSH_1132 ENOG4105C0X amino acid BMWSH_1133 ENOG41076HS cation diffusion facilitator family transporter BMWSH_1134 ENOG4105CKK Glycosyl transferase, family 2 BMWSH_1140 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BMWSH_1142 ENOG4108SVB resolvase BMWSH_1143 ENOG4105VPS UPF0291 protein BMWSH_1146 ENOG4105VXM UPF0154 protein BMWSH_1147 ENOG4105BZ1 (ABC) transporter BMWSH_1148 ENOG4105BZ1 (ABC) transporter BMWSH_1150 ENOG4107QIV Cytochrome c biogenesis protein BMWSH_1151 ENOG4108U5N UPF0316 protein BMWSH_1154 ENOG4108JPW Aminotransferase BMWSH_1157 ENOG4105C26 Dehydrogenase BMWSH_1160 ENOG4105BZU Histidine kinase BMWSH_1161 ENOG4105CVP deoxyribo-dipyrimidine photolyase BMWSH_1165 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BMWSH_1166 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BMWSH_1168 ENOG4105C7B Threonine dehydratase BMWSH_1170 ENOG4108RCR degv family BMWSH_1172 ENOG4108KF3 Electron transport protein SCO1 SenC BMWSH_1173 ENOG41090WU lipolytic protein G-D-S-L family BMWSH_1178 ENOG4105BZU Histidine kinase BMWSH_1181 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BMWSH_1183 ENOG4108TSC N-acetyltransferase BMWSH_1184 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BMWSH_1186 ENOG4105F0I Aminotransferase BMWSH_1187 ENOG4108TGC Acyltransferase BMWSH_1188 ENOG4105VSD UPF0346 protein BMWSH_1195 ENOG4108N23 SpoOM-related protein BMWSH_1197 ENOG410841Q phosphoesterase PA-phosphatase related protein BMWSH_1198 ENOG4106Z5R BMWSH_1200 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BMWSH_1201 ENOG4105CHH sulfate transporter BMWSH_1205 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BMWSH_1209 ENOG4105C5Y PTS System BMWSH_1211 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BMWSH_1214 ENOG4105FDK ABC transporter BMWSH_1216 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BMWSH_1219 ENOG4108JYZ YitT family BMWSH_1222 ENOG4105DVE abc transporter atp-binding protein BMWSH_1226 ENOG4108NHD germination protein BMWSH_1229 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BMWSH_1233 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C BMWSH_1235 ENOG4105CTQ phosphohexokinase BMWSH_1237 ENOG4107YZX Universal stress protein BMWSH_1238 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BMWSH_1240 ENOG4105C37 (CBS) domain BMWSH_1241 ENOG4105K4I Scp-like extracellular BMWSH_1242 ENOG4105D64 Mechanosensitive ion channel BMWSH_1246 ENOG4108NIW Leucine export protein LeuE BMWSH_1249 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) BMWSH_1250 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BMWSH_1251 ENOG4105C1Q protoporphyrinogen oxidase BMWSH_1260 ENOG4105C85 amino acid BMWSH_1264 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BMWSH_1266 ENOG4105K7W phage-related replication protein BMWSH_1268 ENOG4105KT7 mgtC SapB transporter BMWSH_1269 ENOG4108RYK Nad-dependent epimerase dehydratase BMWSH_1272 ENOG4107RSM transcriptional regulator BMWSH_1274 ENOG4105J7D transcriptional regulator BMWSH_1275 ENOG4105JHY Membrane BMWSH_1279 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BMWSH_1282 ENOG4105E0M Sulfatase BMWSH_1283 ENOG4108RCF TRANSCRIPTIONal BMWSH_1286 ENOG4105CH6 catalase BMWSH_1287 ENOG4105EA8 2-Nitropropane dioxygenase BMWSH_1289 ENOG4105CK2 sodium dicarboxylate symporter BMWSH_1290 ENOG4107TSN permease BMWSH_1291 ENOG4108HGU Histidine kinase BMWSH_1292 ENOG4105ETE Transcriptional regulator (LacI family BMWSH_1295 ENOG4105DRS transport system, permease BMWSH_1297 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMWSH_1299 ENOG4108IJ8 ABC transporter BMWSH_1300 ENOG4105E90 ABC transporter BMWSH_1303 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BMWSH_1306 ENOG4108RCF TRANSCRIPTIONal BMWSH_1308 ENOG4105DC7 peptidase M24 BMWSH_1309 ENOG41064HX Suppressor of fused protein (SUFU) BMWSH_1311 ENOG4105DRR Transcriptional regulator, GntR family BMWSH_1312 ENOG4108S4H thioesterase Superfamily protein BMWSH_1314 ENOG4105F3H Histidine kinase BMWSH_1316 ENOG4105C0H protease BMWSH_1320 ENOG4107ZYR domain protein BMWSH_1321 ENOG4105CZN Potassium uptake protein BMWSH_1323 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BMWSH_1325 ENOG4108IQI permease BMWSH_1329 ENOG4105E1K spore germination protein BMWSH_1332 ENOG4108ZJ4 polysaccharide deacetylase BMWSH_1333 ENOG4105JVQ RNA Polymerase BMWSH_1334 ENOG4108P49 AntiSigma factor BMWSH_1336 ENOG4106YBV Methyl-accepting chemotaxis BMWSH_1341 ENOG4106A3M Cytochrome p-450 BMWSH_1342 ENOG4105KVH Transcriptional regulator BMWSH_1343 ENOG4105E39 Enoyl-CoA hydratase BMWSH_1345 ENOG4105EEM helicase BMWSH_1348 ENOG4105WFK nuclease BMWSH_1349 ENOG4105XTG Pfam:DUF156 BMWSH_1350 ENOG4105ME7 Membrane BMWSH_1353 ENOG4105EWM Histidine kinase BMWSH_1355 ENOG4105C19 ABC transporter BMWSH_1363 ENOG4108HKT sucrose-6-phosphate hydrolase BMWSH_1367 ENOG4107SWG transcriptional regulator MERR family BMWSH_1369 ENOG4105CPC Aldo Keto reductase BMWSH_1370 ENOG4105VUF Transcriptional regulator BMWSH_1375 ENOG4105WCN acetyltransferase BMWSH_1383 ENOG4105CTD carboxy-peptidase BMWSH_1385 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BMWSH_1390 ENOG4107QJZ Glycosyl transferase, family 2 BMWSH_1392 ENOG4107UVV polysaccharide deacetylase BMWSH_1393 ENOG4105BZU Histidine kinase BMWSH_1395 ENOG4108ZRV stage ii sporulation protein p BMWSH_1399 ENOG4108XI2 Domain of unknown function (DUF1963) BMWSH_1401 ENOG4105C26 Dehydrogenase BMWSH_1402 ENOG4105C85 amino acid BMWSH_1410 ENOG4105QIV RNA polymerase BMWSH_1412 ENOG4107MII Sugar-specific transcriptional regulator TrmB BMWSH_1413 ENOG4105CZM Major Facilitator BMWSH_1414 ENOG4105K4H Nlp p60 protein BMWSH_1417 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BMWSH_1418 ENOG4106I4J membrane BMWSH_1424 ENOG4108KAM Transcriptional regulator BMWSH_1425 ENOG4105C7F AcnD-accessory protein PrpF BMWSH_1431 ENOG4108JQ9 ABC transporter BMWSH_1432 ENOG4105UIB (ABC) transporter BMWSH_1435 ENOG4108RIR Molybdenum cofactor biosynthesis protein BMWSH_1437 ENOG4105CVM Molybdenum cofactor synthesis domain protein BMWSH_1446 ENOG41086D8 Transcriptional regulator BMWSH_1461 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BMWSH_1463 ENOG4105YWU small acid-soluble spore protein BMWSH_1469 ENOG41067QW Transcriptional regulator BMWSH_1472 ENOG4108UW5 maltose o-acetyltransferase BMWSH_1474 ENOG4105ST3 Transcriptional regulator BMWSH_1477 ENOG4105DTD Dehydrogenase BMWSH_1478 ENOG4105F27 Major Facilitator BMWSH_1480 ENOG4108W5M transcriptional regulator BMWSH_1482 ENOG4105K7K Transcriptional regulator BMWSH_1486 ENOG4105DCF alanine dehydrogenase BMWSH_1489 ENOG4107RB3 L-asparaginase BMWSH_1490 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BMWSH_1491 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BMWSH_1492 ENOG4105C5Y PTS System BMWSH_1494 ENOG4105DWV Homoserine O-trans-acetylase BMWSH_1495 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BMWSH_1496 ENOG4107FCW Abortive infection protein BMWSH_1509 ENOG4105EMN RNA polymerase sigma factor BMWSH_1512 ENOG4105WS7 Cation transport regulator BMWSH_1518 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMWSH_1524 ENOG4108VGI doxx family BMWSH_1525 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BMWSH_1527 ENOG4105CHJ isochorismatase hydrolase BMWSH_1532 ENOG41067QW Transcriptional regulator BMWSH_1537 ENOG4107V2S Transcriptional regulator BMWSH_1538 ENOG4105MDS 4-oxalocrotonate tautomerase BMWSH_1543 ENOG4105DHF Membrane BMWSH_1548 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BMWSH_1549 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BMWSH_1554 ENOG4105CT4 transporter BMWSH_1555 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BMWSH_1557 ENOG4105CJQ hydrolase, family 31 BMWSH_1559 ENOG4105FDP GntR family transcriptional regulator BMWSH_1562 ENOG4105CKI cobalamin synthesis protein BMWSH_1563 ENOG4105DHP deoxycytidine triphosphate deaminase BMWSH_1564 ENOG4105CKI cobalamin synthesis protein BMWSH_1566 ENOG4105CI1 PTS System BMWSH_1567 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BMWSH_1568 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BMWSH_1571 ENOG41090E6 transcriptional regulator MERR family BMWSH_1572 ENOG41090E6 transcriptional regulator MERR family BMWSH_1574 ENOG41068WN BMWSH_1575 ENOG4108V4B ThiJ pfpI BMWSH_1584 ENOG41080TC multidrug resistance protein BMWSH_1585 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BMWSH_1587 ENOG4108JUA Transcriptional regulator BMWSH_1588 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BMWSH_1589 ENOG4108IJ0 Aspartate ammonia-lyase BMWSH_1590 ENOG4107QTZ amino acid BMWSH_1593 ENOG4105KVH Transcriptional regulator BMWSH_1595 ENOG4105CB2 alcohol dehydrogenase BMWSH_1601 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMWSH_1603 ENOG4105ST3 Transcriptional regulator BMWSH_1606 ENOG4105CZ9 Domain of unknown function (DU1801) BMWSH_1607 ENOG4108ZMX Domain of unknown function (DU1801) BMWSH_1615 ENOG4105D9N nucleoside BMWSH_1616 ENOG4108RPX mosc domain containing protein BMWSH_1618 ENOG4107RT3 EamA-like transporter family BMWSH_1628 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase BMWSH_1631 ENOG4105CE1 Ferrous iron transport protein b BMWSH_1632 ENOG4105CE1 Ferrous iron transport protein b BMWSH_1634 ENOG4107TVP HD domain protein BMWSH_1635 ENOG4105CMD Transcriptional regulator, GntR family BMWSH_1636 ENOG4105CMG Carbohydrate kinase BMWSH_1638 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BMWSH_1639 ENOG4105C54 Major Facilitator superfamily BMWSH_1644 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BMWSH_1658 ENOG4105C5I Dehydrogenase BMWSH_1660 ENOG410667J hydrolase BMWSH_1661 ENOG4105E98 transcriptional regulator DeoR family BMWSH_1663 ENOG4105XPP Protein of unknown function (DUF1275) BMWSH_1667 ENOG4105JXH GntR family transcriptional regulator BMWSH_1668 ENOG4108T2C cysteine dioxygenase type I BMWSH_1669 ENOG4107T8P acyl-Coa dehydrogenase BMWSH_1670 ENOG4108KSA LysR family transcriptional regulator BMWSH_1672 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BMWSH_1673 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BMWSH_1674 ENOG4105E2Y ABC, transporter BMWSH_1676 ENOG4105E39 Enoyl-CoA hydratase BMWSH_1677 ENOG4105GVF (ABC) transporter BMWSH_1678 ENOG4105GVF (ABC) transporter BMWSH_1680 ENOG4105GVF (ABC) transporter BMWSH_1685 ENOG4105F1N DNA alkylation repair BMWSH_1690 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BMWSH_1698 ENOG4107QKS N-acylglucosamine 2-epimerase BMWSH_1700 ENOG4108VXD carboxy-peptidase BMWSH_1701 ENOG4105BZU Histidine kinase BMWSH_1702 ENOG4105C8Q Methyl-accepting chemotaxis BMWSH_1704 ENOG4105VEQ Cold shock protein BMWSH_1709 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BMWSH_1713 ENOG4105VUF Transcriptional regulator BMWSH_1714 ENOG4105DQ4 alcohol dehydrogenase BMWSH_1718 ENOG4105EGI Transcriptional regulator BMWSH_1723 ENOG4105CJ1 ABC, transporter BMWSH_1726 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMWSH_1729 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BMWSH_1731 ENOG4105KAC Antibiotic biosynthesis monooxygenase BMWSH_1735 ENOG4108X4Q Hydrolase BMWSH_1743 ENOG4105CNI cell division protein FtsW BMWSH_1747 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BMWSH_1755 ENOG4105D2H Uronic isomerase BMWSH_1757 ENOG4105DMW Dehydrogenase reductase BMWSH_1758 ENOG4105DVM PP-loop domain protein BMWSH_1760 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase BMWSH_1761 ENOG4105C8M UPF0272 protein BMWSH_1762 ENOG4107WBR Protein of unknown function DUF111 BMWSH_1763 ENOG4105CT4 transporter BMWSH_1765 ENOG4105CHH sulfate transporter BMWSH_1775 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BMWSH_1781 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BMWSH_1783 ENOG4108W15 Protein of unknown function (DUF1456) BMWSH_1800 ENOG41068WN BMWSH_1801 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BMWSH_1802 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BMWSH_1803 ENOG4105KVH Transcriptional regulator BMWSH_1806 ENOG4108ZJ4 polysaccharide deacetylase BMWSH_1807 ENOG4108V0P LemA family BMWSH_1811 ENOG4105C26 Dehydrogenase BMWSH_1812 ENOG4108TVJ Nitroreductase BMWSH_1813 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BMWSH_1815 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BMWSH_1817 ENOG4105CS2 ec 3.2.1.21 BMWSH_1823 ENOG4105D94 Major Facilitator Superfamily BMWSH_1824 ENOG4107RSM transcriptional regulator BMWSH_1826 ENOG41080UX Methyltransferase BMWSH_1828 ENOG4105N14 lysine exporter protein LysE YggA BMWSH_1831 ENOG4105X3H Excalibur domain protein BMWSH_1834 ENOG4105CS2 ec 3.2.1.21 BMWSH_1836 ENOG4108S3Y transcriptional regulator BMWSH_1840 ENOG4105GZI Transcriptional regulator BMWSH_1847 ENOG4105XTG Pfam:DUF156 BMWSH_1848 ENOG4105VFE sira family BMWSH_1849 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BMWSH_1854 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BMWSH_1857 ENOG4108HVR ABC transporter, permease BMWSH_1858 ENOG4105C19 ABC transporter BMWSH_1859 ENOG4105EWM Histidine kinase BMWSH_1860 ENOG4105CJZ response regulator BMWSH_1866 ENOG4108IYU L-aspartate oxidase BMWSH_1868 ENOG4105F6J Alpha beta hydrolase fold BMWSH_1869 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BMWSH_1875 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BMWSH_1878 ENOG41081I9 integral membrane protein BMWSH_1879 ENOG4105EGI Transcriptional regulator BMWSH_1881 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth BMWSH_1884 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth BMWSH_1890 ENOG4107ETC gas vesicle protein BMWSH_1892 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) BMWSH_1896 ENOG4108UZ3 Transporter BMWSH_1897 ENOG4108UZ3 Transporter BMWSH_1899 ENOG4107QM2 Aldo Keto reductase BMWSH_1905 ENOG4105MWK D-amino acid dehydrogenase, small subunit BMWSH_1906 ENOG4105D9U N-acetyltransferase BMWSH_1907 ENOG4105BZU Histidine kinase BMWSH_1911 ENOG4105EFI regulatoR BMWSH_1912 ENOG4105BZU Histidine kinase BMWSH_1913 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BMWSH_1914 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BMWSH_1916 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BMWSH_1917 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BMWSH_1922 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BMWSH_1936 ENOG4108XG2 Histidine kinase BMWSH_1937 ENOG4106AXJ AraC family transcriptional regulator BMWSH_1938 ENOG4105N14 lysine exporter protein LysE YggA BMWSH_1942 ENOG4105WEF catalase BMWSH_1944 ENOG41067SE Tetr family transcriptional regulator BMWSH_1945 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BMWSH_1948 ENOG4105NAE bifunctional deaminase-reductase domain protein BMWSH_1952 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) BMWSH_1953 ENOG4108XNA Gas vesicle BMWSH_1954 ENOG4107ETC gas vesicle protein BMWSH_1959 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth BMWSH_1963 ENOG41062ES Transcriptional regulator BMWSH_1965 ENOG4108ZCF integral membrane protein BMWSH_1966 ENOG4108JCI Transcriptional regulator BMWSH_1967 ENOG4108UMN azlc family BMWSH_1969 ENOG4105C98 muts2 protein BMWSH_1975 ENOG4105C3F Signal peptidase i BMWSH_1976 ENOG4105NF4 modulator of drug activity BMWSH_1982 ENOG4105F0V Cell wall hydrolase BMWSH_1983 ENOG4105DHS permease protein BMWSH_1984 ENOG4105CM4 permease protein BMWSH_1990 ENOG4108RYK Nad-dependent epimerase dehydratase BMWSH_1993 ENOG4108QY0 Membrane BMWSH_1994 ENOG4105VEQ Cold shock protein BMWSH_1995 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BMWSH_1996 ENOG410814C multidrug resistance protein BMWSH_1999 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BMWSH_2007 ENOG4105D0M Protease HtpX homolog BMWSH_2008 ENOG4108R9S DSBA oxidoreductase BMWSH_2013 ENOG4108JYZ YitT family BMWSH_2019 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BMWSH_2021 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BMWSH_2024 ENOG41087NI Sulfite exporter TauE/SafE BMWSH_2031 ENOG4107QTZ amino acid BMWSH_2032 ENOG410829K Lysine exporter protein (Lyse ygga) BMWSH_2036 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase BMWSH_2045 ENOG4105E2S oxidase) subunit II BMWSH_2046 ENOG4105BZ9 Cytochrome C oxidase, subunit I BMWSH_2048 ENOG41060D1 Quinol oxidase BMWSH_2052 ENOG41068WN BMWSH_2055 ENOG4105CI2 imidazolone-5-propionate hydrolase BMWSH_2057 ENOG4105VCH membrane BMWSH_2063 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BMWSH_2073 ENOG4108MK9 spermidine N(1)-acetyltransferase BMWSH_2074 ENOG4107TXC Transcriptional regulator BMWSH_2075 ENOG41067TZ transcriptional regulator, MarR family BMWSH_2076 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMWSH_2079 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BMWSH_2080 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BMWSH_2082 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BMWSH_2083 ENOG41068WN BMWSH_2085 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BMWSH_2086 ENOG4105C6K Malic enzyme BMWSH_2091 ENOG4108Z40 Transcriptional regulator BMWSH_2092 ENOG4107QTZ amino acid BMWSH_2096 ENOG4105WAB arsR family transcriptional regulator BMWSH_2097 ENOG4105CT4 transporter BMWSH_2100 ENOG4108IMY Transcriptional regulator BMWSH_2101 ENOG4105HDK L-asparaginase BMWSH_2102 ENOG4108IJ0 Aspartate ammonia-lyase BMWSH_2105 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BMWSH_2108 ENOG4107BMA Transglycosylase associated protein BMWSH_2116 ENOG4105BZU Histidine kinase BMWSH_2120 ENOG4105CMU LysR family (Transcriptional regulator BMWSH_2122 ENOG4105BZN citrate synthase BMWSH_2124 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BMWSH_2125 ENOG4107AYK membrAne BMWSH_2130 ENOG4108JYZ YitT family BMWSH_2131 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BMWSH_2134 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BMWSH_2138 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BMWSH_2139 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BMWSH_2142 ENOG4105RHY Pfam:UPF0157 BMWSH_2145 ENOG4108DBC nitroreductase BMWSH_2147 ENOG4105YVS arsR family transcriptional regulator BMWSH_2153 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BMWSH_2157 ENOG4105C3F Signal peptidase i BMWSH_2158 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BMWSH_2159 ENOG410635A Membrane BMWSH_2167 ENOG4105C8J )-transporter BMWSH_2169 ENOG4105CH6 catalase BMWSH_2172 ENOG4105G9B Transcriptional regulator BMWSH_2174 ENOG4105C5R Aminotransferase BMWSH_2175 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BMWSH_2176 ENOG4105CAH Chromate BMWSH_2177 ENOG4105FGV Chromate BMWSH_2179 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BMWSH_2181 ENOG4105EVN Prephenate dehydrogenase BMWSH_2187 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BMWSH_2190 ENOG4105C37 (CBS) domain BMWSH_2193 ENOG4108RMU ferritin dps family protein BMWSH_2197 ENOG4105K7W phage-related replication protein BMWSH_2202 ENOG4105BZ1 (ABC) transporter BMWSH_2207 ENOG4105T38 integral membrane protein BMWSH_2209 ENOG4105BZ4 penicillin-binding protein BMWSH_2210 ENOG4105FBA Phospholipase Carboxylesterase BMWSH_2213 ENOG4107ZTW SNARE associated Golgi BMWSH_2215 ENOG4108DBC nitroreductase BMWSH_2216 ENOG41069ER domain protein BMWSH_2218 ENOG4108I0Q anthranilate phosphoribosyltransferase BMWSH_2220 ENOG4108YZ9 Urea amidohydrolase subunit gamma BMWSH_2221 ENOG4105KI2 Urea amidohydrolase subunit beta BMWSH_2223 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) BMWSH_2232 ENOG4105K64 Glycosyl transferase, family 2 BMWSH_2233 ENOG4105EWK phytoene BMWSH_2238 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BMWSH_2240 ENOG4107QTZ amino acid BMWSH_2242 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BMWSH_2243 ENOG4105EHG Permease protein BMWSH_2244 ENOG4108IPW abc transporter atp-binding protein BMWSH_2252 ENOG4105FDT acyl-CoA dehydrogenase BMWSH_2253 ENOG4105RHY Pfam:UPF0157 BMWSH_2256 ENOG4105D74 hydrolase BMWSH_2259 ENOG4105CFC Transporter BMWSH_2260 ENOG4105BZU Histidine kinase BMWSH_2264 ENOG4105C32 Amino acid ABC transporter (Permease) BMWSH_2265 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BMWSH_2272 ENOG4105DHF Membrane BMWSH_2274 ENOG4108X3M OsmC Ohr family protein BMWSH_2278 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BMWSH_2279 ENOG4105C7S Dehydrogenase BMWSH_2283 ENOG4105BZU Histidine kinase BMWSH_2285 ENOG4108VXD carboxy-peptidase BMWSH_2286 ENOG4105H67 Protein of unknown function (DUF421) BMWSH_2288 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BMWSH_2290 ENOG4105D7N magnesium and cobalt transport protein CorA BMWSH_2291 ENOG4106SCS STAS domain BMWSH_2292 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BMWSH_2293 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BMWSH_2296 ENOG4107I77 yiaA/B two helix domain BMWSH_2304 ENOG41069JR BMWSH_2305 ENOG4105DA5 (ABC) transporter BMWSH_2311 ENOG4105DAA L-lactate BMWSH_2313 ENOG4105CQB FAD linked oxidase domain protein BMWSH_2314 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BMWSH_2315 ENOG4105CQB FAD linked oxidase domain protein BMWSH_2316 ENOG4105C82 Malate synthase BMWSH_2318 ENOG4107HP6 Transcriptional regulator BMWSH_2320 ENOG4105VTR Integrase BMWSH_2339 ENOG4105D8X mechanosensitive ion channel BMWSH_2345 ENOG4105J7I hydrolase BMWSH_2346 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BMWSH_2347 ENOG4105DWT malate dehydrogenase (quinone) BMWSH_2353 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BMWSH_2356 ENOG4107RRN ABC transporter substrate-binding protein BMWSH_2357 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BMWSH_2358 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BMWSH_2360 ENOG4108JQ7 (ABC) transporter BMWSH_2364 ENOG4105EXU Membrane BMWSH_2366 ENOG4105C37 (CBS) domain BMWSH_2367 ENOG4107SUZ Sodium/hydrogen exchanger family BMWSH_2373 ENOG4105CHR reductase BMWSH_2383 ENOG4107V2S Transcriptional regulator BMWSH_2384 ENOG4107QW4 alcohol dehydrogenase BMWSH_2387 ENOG4105CUC YeeE YedE family protein BMWSH_2392 ENOG4105CRW Short chain fatty acid transporter BMWSH_2396 ENOG4107FKK extracellular solute-binding protein family 1 BMWSH_2401 ENOG4105KK4 UPF0060 membrane protein BMWSH_2402 ENOG41069FQ Metallo-beta-lactamase superfamily BMWSH_2403 ENOG4105D0M Protease HtpX homolog BMWSH_2406 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BMWSH_2411 ENOG4105CFI type iii restriction protein res subunit BMWSH_2412 ENOG4107RHR regulatoR BMWSH_2415 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BMWSH_2416 ENOG4105KG3 cytidine deaminase BMWSH_2417 ENOG4105D9N nucleoside BMWSH_2418 ENOG4105IW1 AmiS UreI transporter BMWSH_2421 ENOG4105KAF membrAne BMWSH_2422 ENOG4105KAF membrAne BMWSH_2426 ENOG4105C3M thioredoxin reductase BMWSH_2429 ENOG4105KAF membrAne BMWSH_2430 ENOG4105C0A alcohol dehydrogenase BMWSH_2431 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BMWSH_2432 ENOG4107QQ0 gntp family BMWSH_2433 ENOG4105BZW Glycerate kinase BMWSH_2439 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BMWSH_2441 ENOG4108UB7 BMWSH_2445 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BMWSH_2446 ENOG4105I1K ABC transporter BMWSH_2452 ENOG4107EV6 Inherit from COG: YD repeat protein BMWSH_2466 ENOG4105DWT malate dehydrogenase (quinone) BMWSH_2476 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BMWSH_2479 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BMWSH_2482 ENOG4105EC3 peptidase S51, dipeptidase E BMWSH_2487 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BMWSH_2488 ENOG41069ER domain protein BMWSH_2489 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMWSH_2490 ENOG4105H67 Protein of unknown function (DUF421) BMWSH_2491 ENOG4105DY9 regulatoR BMWSH_2492 ENOG4105CYC Transferase BMWSH_2502 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BMWSH_2504 ENOG4106KE4 Dehydrogenase BMWSH_2506 ENOG4105CJ1 ABC, transporter BMWSH_2507 ENOG4108TU7 Inherit from COG: (ABC) transporter BMWSH_2510 ENOG4105CGH 5'-nucleotidase BMWSH_2511 ENOG4108N0M stress protein BMWSH_2512 ENOG4106FN3 tellurium resistance protein BMWSH_2513 ENOG4106FN3 tellurium resistance protein BMWSH_2514 ENOG4108TTB tellurium resistance protein BMWSH_2517 ENOG4105E98 transcriptional regulator DeoR family BMWSH_2518 ENOG4105D9R oxidoreductase BMWSH_2519 ENOG41090KN UPF0303 protein BMWSH_2521 ENOG4105CGK Exodeoxyribonuclease III BMWSH_2522 ENOG4105FS7 Transcriptional regulator BMWSH_2524 ENOG4105CW7 secretion protein, HlyD family BMWSH_2525 ENOG4105UQX Mate efflux family protein BMWSH_2545 ENOG4105CUB amino acid BMWSH_2548 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BMWSH_2549 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BMWSH_2550 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BMWSH_2551 ENOG4107T5V SNARE associated Golgi BMWSH_2553 ENOG4105DEN Luciferase family BMWSH_2560 ENOG4105CE7 Amidase, hydantoinase carbamoylase family BMWSH_2561 ENOG4105WH1 Two component transcriptional regulator luxr family BMWSH_2563 ENOG4105CJ1 ABC, transporter BMWSH_2566 ENOG4105C0A alcohol dehydrogenase BMWSH_2567 ENOG4105CY2 Citrate transporter BMWSH_2569 ENOG4107R7Y intracellular protease Pfpi family BMWSH_2571 ENOG4105CQB FAD linked oxidase domain protein BMWSH_2572 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BMWSH_2573 ENOG4105DEN Luciferase family BMWSH_2577 ENOG4107TT2 Auxin Efflux Carrier BMWSH_2578 ENOG4106P55 Transcriptional regulator BMWSH_2579 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BMWSH_2580 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BMWSH_2581 ENOG41069ZX BMWSH_2582 ENOG41069ZX BMWSH_2584 ENOG4105DJB Major Facilitator Superfamily BMWSH_2585 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B BMWSH_2586 ENOG4105C6K Malic enzyme BMWSH_2587 ENOG4107TT2 Auxin Efflux Carrier BMWSH_2595 ENOG4105DER m42 family BMWSH_2600 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BMWSH_2602 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase BMWSH_2603 ENOG4108ZRV stage ii sporulation protein p BMWSH_2605 ENOG4107QTZ amino acid BMWSH_2609 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMWSH_2610 ENOG4105CHH sulfate transporter BMWSH_2611 ENOG4108V2W Carbonate dehydratase BMWSH_2613 ENOG4107SWG transcriptional regulator MERR family BMWSH_2614 ENOG4105DXB Major Facilitator superfamily BMWSH_2616 ENOG4105C6X Major Facilitator BMWSH_2617 ENOG4105BZG amino acid carrier protein BMWSH_2619 ENOG4107U9T Pfam:Ribonuclease_BN BMWSH_2622 ENOG4105VBF alkaline shock protein BMWSH_2623 ENOG4105EWC Purine nucleoside phosphorylase BMWSH_2624 ENOG4105F27 Major Facilitator BMWSH_2627 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BMWSH_2644 ENOG4105FDF Could be involved in DNA repair (By similarity) BMWSH_2647 ENOG4107DZX Small, acid-soluble spore protein P BMWSH_2648 ENOG410746C Acid-soluble spore protein O BMWSH_2649 ENOG4108I0Z Aconitate hydratase BMWSH_2650 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BMWSH_2652 ENOG41075ZD Small, acid-soluble spore protein N BMWSH_2657 ENOG4105W8X HesB YadR YfhF-family protein BMWSH_2658 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BMWSH_2659 ENOG4105K4P CoA-binding domain protein BMWSH_2660 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BMWSH_2662 ENOG4107S9D Alpha beta hydrolase BMWSH_2667 ENOG4108Z7F N-acetyltransferase BMWSH_2668 ENOG4108IQI permease BMWSH_2670 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase BMWSH_2671 ENOG4105CPD ethanolamine ammonia-lyase BMWSH_2672 ENOG4107FQ9 ethanolamine ammonia-lyase BMWSH_2673 ENOG4107R55 ethanolamine transporter BMWSH_2677 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BMWSH_2679 ENOG4105RV9 Transcriptional regulator BMWSH_2680 ENOG4105U0R haloacid dehalogenase-like hydrolase BMWSH_2683 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BMWSH_2686 ENOG4108MK9 spermidine N(1)-acetyltransferase BMWSH_2687 ENOG4105VT2 5-hydroxyisourate hydrolase BMWSH_2690 ENOG4105F6E Acyl-transferase BMWSH_2692 ENOG4105CM2 brancheD-chain amino acid aminotransferase BMWSH_2696 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BMWSH_2697 ENOG4105E5G Alpha beta hydrolase fold BMWSH_2698 ENOG4105C01 Dihydroxy-acid dehydratase BMWSH_2699 ENOG41082BV acetyltransferase BMWSH_2705 ENOG4105BZU Histidine kinase BMWSH_2706 ENOG4105WH1 Two component transcriptional regulator luxr family BMWSH_2710 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BMWSH_2712 ENOG4107ZYJ bioY protein BMWSH_2713 ENOG4107F3J Amp-dependent synthetase and ligase BMWSH_2720 ENOG4105CG3 alpha amylase, catalytic region BMWSH_2721 ENOG4105E7W lamb ycsf family protein BMWSH_2722 ENOG4105C5A transporter BMWSH_2723 ENOG4105CFM UPF0317 protein BMWSH_2726 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BMWSH_2727 ENOG4107258 Transcriptional regulator BMWSH_2728 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BMWSH_2730 ENOG4108VCA G U mismatch-specific DNA glycosylase BMWSH_2731 ENOG4105DIN metallophosphoesterase BMWSH_2733 ENOG4108RE9 Phosphodiesterase BMWSH_2735 ENOG4105C8Q Methyl-accepting chemotaxis BMWSH_2737 ENOG4105IQ5 FAD linked oxidase domain protein BMWSH_2740 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BMWSH_2741 ENOG4105TMB Formate nitrite transporter BMWSH_2746 ENOG4105CVK Glutamate decarboxylase BMWSH_2756 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BMWSH_2757 ENOG41073R8 VanW family BMWSH_2758 ENOG41067TZ transcriptional regulator, MarR family BMWSH_2761 ENOG4105P8F nudix hydrolase BMWSH_2764 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BMWSH_2778 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BMWSH_2779 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BMWSH_2780 ENOG4107P26 BMWSH_2782 ENOG4105D82 Glutamate dehydrogenase BMWSH_2784 ENOG4105EUZ Beta-lactamase domain protein BMWSH_2790 ENOG4107Y9U Membrane BMWSH_2793 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BMWSH_2794 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BMWSH_2815 ENOG4108JQ1 Dehydrogenase BMWSH_2816 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BMWSH_2818 ENOG4105NX3 Membrane BMWSH_2821 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BMWSH_2822 ENOG4105C72 UPF0176 protein BMWSH_2823 ENOG4107YUH hydrolase BMWSH_2827 ENOG41082BM Transcriptional regulator, arsr family BMWSH_2830 ENOG4105BZU Histidine kinase BMWSH_2832 ENOG4105EYF MMPL domain protein BMWSH_2833 ENOG41062A4 Transcriptional regulator BMWSH_2834 ENOG4105F27 Major Facilitator BMWSH_2835 ENOG4105CUB amino acid BMWSH_2837 ENOG4105C22 threonyL-tRNA synthetase BMWSH_2838 ENOG4105CBG Sulfatase BMWSH_2840 ENOG4105F0V Cell wall hydrolase BMWSH_2841 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BMWSH_2843 ENOG4105JKW Valine--pyruvate aminotransferase BMWSH_2845 ENOG4108594 Permease of the drug metabolite transporter BMWSH_2847 ENOG4105CPF Cell wall formation (By similarity) BMWSH_2852 ENOG4106XGU BMWSH_2853 ENOG4105C5X domain protein BMWSH_2855 ENOG4108IQI permease BMWSH_2857 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BMWSH_2861 ENOG4108JPW Aminotransferase BMWSH_2862 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BMWSH_2863 ENOG4105CHU acetyl-coa acetyltransferase BMWSH_2864 ENOG4107QNJ CoA-transferase subunit B BMWSH_2865 ENOG4105D6N CoA-transferase, subunit a BMWSH_2868 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BMWSH_2869 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BMWSH_2870 ENOG4105CGU Enoyl-CoA hydratase BMWSH_2871 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BMWSH_2872 ENOG4105C1G acyl-Coa dehydrogenase BMWSH_2873 ENOG4108N5B 2-phosphosulfolactate phosphatase BMWSH_2876 ENOG4105E39 Enoyl-CoA hydratase BMWSH_2877 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BMWSH_2879 ENOG4105CEY Amp-dependent synthetase and ligase BMWSH_2880 ENOG4105CHR reductase BMWSH_2883 ENOG4105BZU Histidine kinase BMWSH_2885 ENOG4107VFR oxidoreductase BMWSH_2887 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BMWSH_2888 ENOG4105CK2 sodium dicarboxylate symporter BMWSH_2891 ENOG4105CMU LysR family (Transcriptional regulator BMWSH_2897 ENOG4105CIN aminoacyl-histidine dipeptidase BMWSH_2898 ENOG4105DTD Dehydrogenase BMWSH_2899 ENOG4105CY2 Citrate transporter BMWSH_2902 ENOG4105D4T Citrate transporter BMWSH_2903 ENOG4108V9W transcriptional regulatory protein BMWSH_2904 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BMWSH_2905 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BMWSH_2906 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BMWSH_2907 ENOG4108IXY short-chain dehydrogenase reductase BMWSH_2909 ENOG4108RCM Nitroreductase BMWSH_2917 ENOG4105BZU Histidine kinase BMWSH_2919 ENOG4107YXZ hydrolase, family 25 BMWSH_2921 ENOG4105C9Q fumarate hydratase class II BMWSH_2925 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BMWSH_2928 ENOG4105E1V na solute symporter BMWSH_2931 ENOG4106SCS STAS domain BMWSH_2940 ENOG4107U9T Pfam:Ribonuclease_BN BMWSH_2942 ENOG4107TUM Amidinotransferase BMWSH_2944 ENOG4107R13 MMPL domain protein BMWSH_2947 ENOG4105JSC dimethylmenaquinone methyltransferase BMWSH_2950 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BMWSH_2951 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BMWSH_2952 ENOG4105II7 pyrroline-5-carboxylate reductase BMWSH_2953 ENOG4105BZU Histidine kinase BMWSH_2957 ENOG41069ER domain protein BMWSH_2959 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) BMWSH_2963 ENOG4105K56 Transcriptional regulator BMWSH_2964 ENOG4108ZHJ Organic hydroperoxide resistance protein BMWSH_2967 ENOG4105EMN RNA polymerase sigma factor BMWSH_2969 ENOG4105DVE abc transporter atp-binding protein BMWSH_2970 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BMWSH_2971 ENOG4105DUM transcriptional regulator, lysR family BMWSH_2972 ENOG4105D94 Major Facilitator Superfamily BMWSH_2973 ENOG4105KWG Pfam:DUF1696 BMWSH_2976 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BMWSH_2980 ENOG4105C26 Dehydrogenase BMWSH_2984 ENOG4105C9U ATP-dependent DNA helicase RecQ BMWSH_2993 ENOG41073R8 VanW family BMWSH_2997 ENOG4105E1K spore germination protein BMWSH_3000 ENOG4107S6Z Na H antiporter BMWSH_3001 ENOG4107RZC phospholipase d BMWSH_3002 ENOG4107RZC phospholipase d BMWSH_3007 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BMWSH_3009 ENOG4105C9U ATP-dependent DNA helicase RecQ BMWSH_3013 ENOG4105F6S Spore photoproduct lyase BMWSH_3017 ENOG4107S6Z Na H antiporter BMWSH_3019 ENOG4105CJ1 ABC, transporter BMWSH_3020 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BMWSH_3021 ENOG4108NHD germination protein BMWSH_3022 ENOG4108Q8B Spore germination protein BMWSH_3025 ENOG4105C5H ABC transporter BMWSH_3026 ENOG4108RNG Permease of the drug metabolite transporter BMWSH_3027 ENOG4105FTV AraC Family Transcriptional Regulator BMWSH_3029 ENOG4105DEN Luciferase family BMWSH_3030 ENOG4105EU0 Major facilitator Superfamily BMWSH_3031 ENOG410855V Acylphosphatase BMWSH_3032 ENOG4105DTD Dehydrogenase BMWSH_3033 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BMWSH_3034 ENOG41060GV RNA binding s1 domain protein BMWSH_3035 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BMWSH_3036 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BMWSH_3037 ENOG4105DAP Nicotinate phosphoribosyltransferase BMWSH_3039 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BMWSH_3042 ENOG4108IMY Transcriptional regulator BMWSH_3046 ENOG410756H nucleotidyltransferase BMWSH_3051 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BMWSH_3052 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BMWSH_3059 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BMWSH_3060 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BMWSH_3061 ENOG4108NGU Transcriptional regulator BMWSH_3064 ENOG4105JAB phenazine biosynthesis protein, phzf family BMWSH_3066 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BMWSH_3068 ENOG4105EWU Squalene--hopene cyclase BMWSH_3071 ENOG4105DKW ABC transporter BMWSH_3072 ENOG4108428 Inherit from COG: -acetyltransferase BMWSH_3074 ENOG41075H3 AraC family transcriptional regulator BMWSH_3077 ENOG4108UZ3 Transporter BMWSH_3078 ENOG4107T89 von Willebrand factor, type A BMWSH_3079 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BMWSH_3086 ENOG410606W general stress protein BMWSH_3090 ENOG41062JF Transcriptional regulator BMWSH_3091 ENOG4105I4A GCN5-related N-acetyltransferase BMWSH_3094 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BMWSH_3096 ENOG4108VX5 3-methyladenine DNA glycosylase BMWSH_3097 ENOG4107QP6 Xylose isomerase domain protein TIM barrel BMWSH_3098 ENOG4105CK5 oxidoreductase BMWSH_3101 ENOG4105ETE Transcriptional regulator (LacI family BMWSH_3102 ENOG4105F0V Cell wall hydrolase BMWSH_3103 ENOG4105C8J )-transporter BMWSH_3107 ENOG4105ETU transcriptional activator (TenA BMWSH_3108 ENOG4105C26 Dehydrogenase BMWSH_3110 ENOG4108W6C Dehydrogenase BMWSH_3113 ENOG4105EWK phytoene BMWSH_3114 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BMWSH_3117 ENOG4105CFH Aspartokinase BMWSH_3118 ENOG4105DM4 PTS System BMWSH_3119 ENOG4105DE4 1-phosphofructokinase BMWSH_3120 ENOG4105E98 transcriptional regulator DeoR family BMWSH_3123 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BMWSH_3128 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMWSH_3131 ENOG4105ECW sulfate abc transporter BMWSH_3132 ENOG4107Z6A sulfate abc transporter permease BMWSH_3133 ENOG4108I5D sulfate abc transporter BMWSH_3134 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BMWSH_3137 ENOG4105BZU Histidine kinase BMWSH_3138 ENOG4105EFI regulatoR BMWSH_3139 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BMWSH_3141 ENOG4105CKK Glycosyl transferase, family 2 BMWSH_3142 ENOG4105EDW glycosyl transferase, family 39 BMWSH_3147 ENOG41067MG lrgb family BMWSH_3149 ENOG41061AU MarR family Transcriptional regulator BMWSH_3151 ENOG4105WEF catalase BMWSH_3153 ENOG4107RZC phospholipase d BMWSH_3156 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BMWSH_3157 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BMWSH_3161 ENOG4105BZ8 glutamate synthase BMWSH_3162 ENOG4105CBC glutamate synthase BMWSH_3163 ENOG4105C5Q Transcriptional regulator BMWSH_3164 ENOG4108R1P BMWSH_3165 ENOG41069DP small acid-soluble spore protein BMWSH_3170 ENOG4107SWG transcriptional regulator MERR family BMWSH_3174 ENOG4105K7W phage-related replication protein BMWSH_3175 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BMWSH_3176 ENOG4105D7K pfkb domain protein BMWSH_3179 ENOG4105CKV Membrane BMWSH_3180 ENOG410905X membrane-flanked domain protein BMWSH_3182 ENOG4108URH decarboxylase BMWSH_3187 ENOG4105EDR glucose galactose transporter BMWSH_3188 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BMWSH_3192 ENOG4108JQ1 Dehydrogenase BMWSH_3193 ENOG4108Y83 glucose-6-phosphate isomerase BMWSH_3194 ENOG4105CMG Carbohydrate kinase BMWSH_3195 ENOG4105FDP GntR family transcriptional regulator BMWSH_3199 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BMWSH_3203 ENOG4105CDA abc transporter atp-binding protein BMWSH_3208 ENOG4108XSB acetyltransferase, (GNAT) family BMWSH_3210 ENOG4105DEN Luciferase family BMWSH_3212 ENOG410667J hydrolase BMWSH_3214 ENOG4105C6K Malic enzyme BMWSH_3216 ENOG4105DUX Transporter BMWSH_3217 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) BMWSH_3218 ENOG4105US7 Histidine kinase BMWSH_3219 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMWSH_3221 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BMWSH_3222 ENOG4108TGC Acyltransferase BMWSH_3227 ENOG4105DFD Na H antiporter BMWSH_3228 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BMWSH_3229 ENOG4108NA0 Uncharacterized conserved protein (COG2071) BMWSH_3232 ENOG4105ER2 Ompa motb domain protein BMWSH_3233 ENOG4105E14 MotA TolQ exbB proton channel BMWSH_3237 ENOG41068W2 Cytochrome p-450 BMWSH_3238 ENOG4105C26 Dehydrogenase BMWSH_3239 ENOG4108IUM Glycogen debranching enzyme BMWSH_3240 ENOG4107R6U sodium dicarboxylate symporter BMWSH_3243 ENOG4105BZU Histidine kinase BMWSH_3244 ENOG4105IIU Aminopeptidase BMWSH_3246 ENOG4108ZJ4 polysaccharide deacetylase BMWSH_3250 ENOG4105CDW Resistance protein BMWSH_3256 ENOG41076QQ Glycosyl transferase, family 2 BMWSH_3259 ENOG4105CHR reductase BMWSH_3260 ENOG4107QMU Mate efflux family protein BMWSH_3266 ENOG4108AEY RNA polymerase sigma factor BMWSH_3267 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BMWSH_3268 ENOG4105II7 pyrroline-5-carboxylate reductase BMWSH_3273 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BMWSH_3274 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BMWSH_3278 ENOG4105FR1 rard protein BMWSH_3279 ENOG4108WBT adenosyltransferase BMWSH_3281 ENOG4105CVJ phosphoglycerate mutase BMWSH_3282 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BMWSH_3283 ENOG4108YZT Adenosylcobinamide kinase BMWSH_3284 ENOG4105CIH Imidazole acetol-phosphate transaminase BMWSH_3285 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) BMWSH_3287 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BMWSH_3288 ENOG4105SZ6 Thioredoxin BMWSH_3290 ENOG4107YX5 Pfam:DUF548 BMWSH_3291 ENOG4108Y6J UPF0403 protein BMWSH_3292 ENOG4108ZJ4 polysaccharide deacetylase BMWSH_3294 ENOG4105C5H ABC transporter BMWSH_3296 ENOG4108V06 Glutathione peroxidase BMWSH_3299 ENOG4105CVG Homoserine O-transsuccinylase BMWSH_3306 ENOG4108ZJ4 polysaccharide deacetylase BMWSH_3310 ENOG4105KHC sulfurtransferase BMWSH_3312 ENOG4105X5K response regulator receiver protein BMWSH_3320 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BMWSH_3321 ENOG4105KVH Transcriptional regulator BMWSH_3322 ENOG4105CZM Major Facilitator BMWSH_3323 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BMWSH_3324 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BMWSH_3327 ENOG4108QY0 Membrane BMWSH_3328 ENOG41081VB Hydrolase BMWSH_3329 ENOG4108VUY thioesterase Superfamily protein BMWSH_3331 ENOG4107R5R arsenical pump membrane protein BMWSH_3332 ENOG41082YX Transcriptional regulator, arsr family BMWSH_3341 ENOG41090UD (LipO)protein BMWSH_3343 ENOG4105C59 p-type ATPase BMWSH_3344 ENOG410681U heavy metal transport detoxification protein BMWSH_3345 ENOG4105VPX protein, conserved in bacteria BMWSH_3346 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMWSH_3347 ENOG4105BZU Histidine kinase BMWSH_3348 ENOG4107YZX Universal stress protein BMWSH_3354 ENOG4105CT4 transporter BMWSH_3356 ENOG4105DDI hemolysin-type calcium-binding region BMWSH_3357 ENOG4105CTX dehydratase BMWSH_3358 ENOG4107QZW Altronate oxidoreductase BMWSH_3359 ENOG4107KJX Transcriptional regulator BMWSH_3360 ENOG4105CT4 transporter BMWSH_3361 ENOG4105D2H Uronic isomerase BMWSH_3362 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BMWSH_3363 ENOG4105C02 permease BMWSH_3372 ENOG4105C28 cystathionine BMWSH_3374 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BMWSH_3376 ENOG4107QKR Dehydrogenase BMWSH_3377 ENOG4107RUY (E1 component), alpha subunit BMWSH_3378 ENOG4108J9M Transporter BMWSH_3379 ENOG4105C7N Xanthine uracil vitamin C permease BMWSH_3382 ENOG4105E1J oxidoreductase BMWSH_3383 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BMWSH_3384 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BMWSH_3385 ENOG4107YZX Universal stress protein BMWSH_3387 ENOG4105CCU oxidase (Subunit III) BMWSH_3388 ENOG4105BZ9 Cytochrome C oxidase, subunit I BMWSH_3389 ENOG4105E2S oxidase) subunit II BMWSH_3390 ENOG4108IG5 Transcriptional regulator BMWSH_3394 ENOG41080XP Cbs domain BMWSH_3396 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BMWSH_3402 ENOG4105C26 Dehydrogenase BMWSH_3406 ENOG4105CSH Transporter BMWSH_3409 ENOG4108Z66 YbaK ebsC protein BMWSH_3410 ENOG4108JQ7 (ABC) transporter BMWSH_3412 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BMWSH_3415 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BMWSH_3428 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BMWSH_3434 ENOG4105JSC dimethylmenaquinone methyltransferase BMWSH_3436 ENOG4105D4T Citrate transporter BMWSH_3439 ENOG4105C59 p-type ATPase BMWSH_3442 ENOG4108PJD permease BMWSH_3444 ENOG4105C22 threonyL-tRNA synthetase BMWSH_3449 ENOG4107TXC Transcriptional regulator BMWSH_3453 ENOG4105KVH Transcriptional regulator BMWSH_3455 ENOG4108YV3 Protein of unknown function (DUF2711) BMWSH_3463 ENOG4105CMT Dihydroxyacetone kinase BMWSH_3466 ENOG4108R6W Transcriptional regulator, ARAC family BMWSH_3467 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BMWSH_3469 ENOG4108UZ3 Transporter BMWSH_3471 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BMWSH_3472 ENOG41085FC arsR family transcriptional regulator BMWSH_3474 ENOG41082YX Transcriptional regulator, arsr family BMWSH_3475 ENOG4107R5R arsenical pump membrane protein BMWSH_3478 ENOG4108MK9 spermidine N(1)-acetyltransferase BMWSH_3480 ENOG4108I0C methyltransferase BMWSH_3485 ENOG4105HMI Membrane BMWSH_3487 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BMWSH_3488 ENOG4105VRS hydrolase family 18 BMWSH_3490 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BMWSH_3512 ENOG4105KPY Small multidrug resistance protein BMWSH_3518 ENOG4105XDF Protein of unknown function (DUF1272) BMWSH_3521 ENOG41066F8 ROK family BMWSH_3523 ENOG4105CS2 ec 3.2.1.21 BMWSH_3525 ENOG4105VCP PTS System BMWSH_3526 ENOG4108S3Y transcriptional regulator BMWSH_3527 ENOG4107TS3 membrane protein, TerC BMWSH_3528 ENOG4108XG4 DNA-binding transcriptional regulator BMWSH_3530 ENOG4105EYF MMPL domain protein BMWSH_3537 ENOG4105UPD Calcium Proton BMWSH_3545 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF BMWSH_3548 ENOG4105E1K spore germination protein BMWSH_3552 ENOG4108428 Inherit from COG: -acetyltransferase BMWSH_3555 ENOG4108PSK reductase BMWSH_3560 ENOG4105G7B Protein of unknown function (DUF2992) BMWSH_3562 ENOG4108XEP Alpha Beta Hydrolase Fold protein BMWSH_3563 ENOG4107V2S Transcriptional regulator BMWSH_3573 ENOG4105K4H Nlp p60 protein BMWSH_3581 ENOG4105MKU Transcriptional regulator BMWSH_3583 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 BMWSH_3594 ENOG41082BM Transcriptional regulator, arsr family BMWSH_3595 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BMWSH_3596 ENOG4108U05 Transcriptional regulator BMWSH_3600 ENOG4105KNA -acetyltransferase BMWSH_3607 ENOG4105DYB Isoaspartyl dipeptidase BMWSH_3610 ENOG4105DU0 nucleoside hydrolase BMWSH_3612 ENOG4108903 Formimidoylglutamase BMWSH_3613 ENOG4105CI2 imidazolone-5-propionate hydrolase BMWSH_3615 ENOG4105C84 Histidine ammonia-lyase BMWSH_3618 ENOG4108UIN ybak prolyl-trna synthetase associated region BMWSH_3621 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BMWSH_3623 ENOG4105CPU Monooxygenase BMWSH_3624 ENOG4105D01 (LipO)protein BMWSH_3625 ENOG4108UMI ABC transporter, permease BMWSH_3626 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BMWSH_3627 ENOG4105D01 (LipO)protein BMWSH_3628 ENOG4108UMI ABC transporter, permease BMWSH_3629 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BMWSH_3630 ENOG4105D01 (LipO)protein BMWSH_3634 ENOG4105E5Q amino acid AbC transporter BMWSH_3635 ENOG4108HKT sucrose-6-phosphate hydrolase BMWSH_3636 ENOG4105F3R pts system mannose fructose sorbose family iid BMWSH_3637 ENOG4105YHU PTS system BMWSH_3638 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BMWSH_3639 ENOG4105EDQ levansucrase EC 2.4.1.10 BMWSH_3641 ENOG4105CNG UPF0061 protein BMWSH_3642 ENOG4108HKT sucrose-6-phosphate hydrolase BMWSH_3643 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BMWSH_3644 ENOG4105ETE Transcriptional regulator (LacI family BMWSH_3645 ENOG4105YWU small acid-soluble spore protein BMWSH_3658 ENOG4105CN5 Metallo-Beta-Lactamase BMWSH_3664 ENOG4105C26 Dehydrogenase BMWSH_3667 ENOG4107RGD Major Facilitator superfamily BMWSH_3668 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) BMWSH_3669 ENOG4105EXW epimerase dehydratase BMWSH_3671 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMWSH_3672 ENOG4108UQY Iron-storage protein BMWSH_3673 ENOG4108HKT sucrose-6-phosphate hydrolase BMWSH_3674 ENOG4105EDQ levansucrase EC 2.4.1.10 BMWSH_3675 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BMWSH_3679 ENOG4105CUB amino acid BMWSH_3681 ENOG4108MJI response regulator BMWSH_3682 ENOG4105BZU Histidine kinase BMWSH_3683 ENOG4105BZU Histidine kinase BMWSH_3687 ENOG4108IJ7 Glycine betaine BMWSH_3688 ENOG4105DVW rieske (2Fe-2S) BMWSH_3689 ENOG4105F76 Sarcosine oxidase BMWSH_3691 ENOG4108VA3 3-hexulose-6-phosphate synthase BMWSH_3692 ENOG4105KVH Transcriptional regulator BMWSH_3693 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BMWSH_3697 ENOG4105C2C drug resistance transporter, Bcr CflA BMWSH_3698 ENOG4105C28 cystathionine BMWSH_3699 ENOG4105CAY ferredoxin--nadp reductase BMWSH_3700 ENOG4105E0A ABC, transporter BMWSH_3701 ENOG4108V5C ABC transporter BMWSH_3702 ENOG4105DQ5 transport system permease protein BMWSH_3703 ENOG4105EHG Permease protein BMWSH_3707 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMWSH_3708 ENOG4105CW7 secretion protein, HlyD family BMWSH_3709 ENOG41067TZ transcriptional regulator, MarR family BMWSH_3712 ENOG4107ZXU DSBA oxidoreductase BMWSH_3714 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BMWSH_3720 ENOG41087PP glycosyltransferase MGT family BMWSH_3721 ENOG4105K4H Nlp p60 protein BMWSH_3723 ENOG4108TM9 integral membrane protein BMWSH_3724 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BMWSH_3725 ENOG4105IIP Membrane BMWSH_3727 ENOG4105ECK Fatty Acid Desaturase BMWSH_3728 ENOG4108ZGX Histidine kinase BMWSH_3729 ENOG4108S01 response regulator BMWSH_3734 ENOG4105E0A ABC, transporter BMWSH_3735 ENOG4108U1V ABC transporter, permease BMWSH_3736 ENOG4105DQ5 transport system permease protein BMWSH_3737 ENOG4108HUF Transporter BMWSH_3739 ENOG4108PJD permease BMWSH_3741 ENOG4105BZU Histidine kinase BMWSH_3742 ENOG4105KNA -acetyltransferase BMWSH_3745 ENOG4108JQ7 (ABC) transporter BMWSH_3746 ENOG4107SN7 NLP P60 protein BMWSH_3747 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BMWSH_3749 ENOG4105C3U ABC transporter BMWSH_3750 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BMWSH_3751 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BMWSH_3752 ENOG4108ME1 Peptidase M55 D-aminopeptidase BMWSH_3763 ENOG41081VK Ribonuclease BMWSH_3768 ENOG410756H nucleotidyltransferase BMWSH_3769 ENOG410890F Dynamin family BMWSH_3771 ENOG41065KQ synthase BMWSH_3774 ENOG4105C26 Dehydrogenase BMWSH_3776 ENOG4105F04 LysR family Transcriptional regulator BMWSH_3777 ENOG4105C2W permease BMWSH_3778 ENOG4105C2W permease BMWSH_3780 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BMWSH_3781 ENOG4105CTD carboxy-peptidase BMWSH_3782 ENOG4105CTD carboxy-peptidase BMWSH_3783 ENOG4105DVT helicase BMWSH_3787 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BMWSH_3791 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BMWSH_3793 ENOG4105WH1 Two component transcriptional regulator luxr family BMWSH_3798 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BMWSH_3799 ENOG4106F55 Protein of unknown function (DUF1273) BMWSH_3801 ENOG4107X2U Inherit from COG: Exonuclease-like protein BMWSH_3802 ENOG4108I5C dEAD DEAH box helicase BMWSH_3804 ENOG4105BZU Histidine kinase BMWSH_3807 ENOG4105VEQ Cold shock protein BMWSH_3810 ENOG4105CK7 Sodium proline symporter BMWSH_3813 ENOG4105C28 cystathionine BMWSH_3814 ENOG4105C28 cystathionine BMWSH_3816 ENOG4106UIA BMWSH_3828 ENOG4105BZ4 penicillin-binding protein BMWSH_3830 ENOG4105CSM endonuclease III BMWSH_3833 ENOG4105CHM Aminotransferase BMWSH_3835 ENOG4105YAC BMWSH_3837 ENOG4105DVT helicase BMWSH_3838 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BMWSH_3839 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BMWSH_3841 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BMWSH_3842 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BMWSH_3843 ENOG4105CPK Glycosyl transferase (Group 1 BMWSH_3844 ENOG4105FJR Lmbe family BMWSH_3845 ENOG4108Z5K methylglyoxal synthase BMWSH_3846 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BMWSH_3847 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BMWSH_3848 ENOG4108JYZ YitT family BMWSH_3851 ENOG4106UY4 Inherit from COG: Scp-like extracellular BMWSH_3852 ENOG41080XQ Signal transduction protein with cbs domains BMWSH_3859 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BMWSH_3860 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BMWSH_3861 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BMWSH_3862 ENOG4105CNI cell division protein FtsW BMWSH_3865 ENOG4108IAB Phoh family BMWSH_3870 ENOG4105QA2 BMWSH_3871 ENOG4105CI3 gtp-binding protein typa BMWSH_3873 ENOG4105ECY inositol monophosphatase BMWSH_3876 ENOG4105WBI UPF0223 protein BMWSH_3877 ENOG4105CXN decarboxylase BMWSH_3879 ENOG4105C94 Transporter BMWSH_3882 ENOG4105C7S Dehydrogenase BMWSH_3883 ENOG4105CPP Dehydrogenase, E1 component BMWSH_3887 ENOG4108X4Q Hydrolase BMWSH_3888 ENOG4106EHS UPF0356 protein BMWSH_3889 ENOG4105CN5 Metallo-Beta-Lactamase BMWSH_3890 ENOG4107ZYR domain protein BMWSH_3891 ENOG4105BZ1 (ABC) transporter BMWSH_3892 ENOG4105BZ1 (ABC) transporter BMWSH_3894 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BMWSH_3895 ENOG4105D3R alkyl hydroperoxide reductase BMWSH_3896 ENOG4105D8X mechanosensitive ion channel BMWSH_3898 ENOG4105CH2 amidohydrolase BMWSH_3900 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BMWSH_3903 ENOG4107IN1 Protein of unknown function (DUF1797) BMWSH_3906 ENOG4105EPM Diguanylate phosphodiesterase BMWSH_3907 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BMWSH_3910 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BMWSH_3912 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BMWSH_3914 ENOG4105UIN BMWSH_3915 ENOG4107R88 Chemotaxis protein (CheV) BMWSH_3919 ENOG4105CHM Aminotransferase BMWSH_3921 ENOG4105CHR reductase BMWSH_3924 ENOG4105CMU LysR family (Transcriptional regulator BMWSH_3925 ENOG4105VAW lrga family BMWSH_3926 ENOG41067MG lrgb family BMWSH_3927 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BMWSH_3928 ENOG4105KRI phosphocarrier protein (HPr BMWSH_3931 ENOG4105CID antiterminator BMWSH_3934 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BMWSH_3936 ENOG4108R6K riboflavin synthase, subunit alpha BMWSH_3937 ENOG4108K88 Membrane BMWSH_3949 ENOG4105F0V Cell wall hydrolase BMWSH_3958 ENOG4105K4T epimerase BMWSH_3959 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BMWSH_3960 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BMWSH_3961 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BMWSH_3962 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BMWSH_3967 ENOG4105E1K spore germination protein BMWSH_3972 ENOG4105DFD Na H antiporter BMWSH_3976 ENOG4105BZU Histidine kinase BMWSH_3979 ENOG41090MY MarR family Transcriptional regulator BMWSH_3983 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BMWSH_3985 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BMWSH_3986 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BMWSH_3988 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BMWSH_3989 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BMWSH_3990 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BMWSH_3993 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BMWSH_3994 ENOG4105BZU Histidine kinase BMWSH_3995 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BMWSH_3996 ENOG4107QR9 Iron-sulfur cluster binding protein BMWSH_3997 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BMWSH_3998 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BMWSH_3999 ENOG4105DAP Nicotinate phosphoribosyltransferase BMWSH_4000 ENOG4105JXH GntR family transcriptional regulator BMWSH_4008 ENOG4105CHR reductase BMWSH_4013 ENOG410681C small acid-soluble spore protein BMWSH_4014 ENOG4108WZW RNA polymerase sigma BMWSH_4015 ENOG4107TS3 membrane protein, TerC BMWSH_4016 ENOG4105BZU Histidine kinase BMWSH_4017 ENOG4105DY9 regulatoR BMWSH_4018 ENOG4105G6Z alkaline phosphatase BMWSH_4021 ENOG4108B31 Spore germination protein BMWSH_4022 ENOG4105E0X reductase BMWSH_4026 ENOG4108SDH ABC, transporter BMWSH_4027 ENOG4108IUW ABC transporter BMWSH_4028 ENOG4107Y7X LytTR BMWSH_4029 ENOG4107Y7X LytTR BMWSH_4031 ENOG4105C7N Xanthine uracil vitamin C permease BMWSH_4033 ENOG4105DP8 Major facilitator superfamily MFS_1 BMWSH_4034 ENOG4105RHY Pfam:UPF0157 BMWSH_4040 ENOG4105CH2 amidohydrolase BMWSH_4041 ENOG4108XSB acetyltransferase, (GNAT) family BMWSH_4042 ENOG4105C8Q Methyl-accepting chemotaxis BMWSH_4050 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BMWSH_4053 ENOG4105C37 (CBS) domain BMWSH_4054 ENOG4105CJ1 ABC, transporter BMWSH_4062 ENOG4108UQV Membrane BMWSH_4064 ENOG4105CI1 PTS System BMWSH_4065 ENOG4105CE4 GlcNAc 6-P deacetylase BMWSH_4066 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BMWSH_4067 ENOG4105FDP GntR family transcriptional regulator BMWSH_4068 ENOG4108SU4 UPF0309 protein BMWSH_4073 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BMWSH_4075 ENOG4105D7N magnesium and cobalt transport protein CorA BMWSH_4077 ENOG4108KGH TRANSCRIPTIONal BMWSH_4079 ENOG4107QJQ Mate efflux family protein BMWSH_4084 ENOG4105D7K pfkb domain protein BMWSH_4086 ENOG4108QTI )-transporter BMWSH_4087 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BMWSH_4088 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BMWSH_4089 ENOG4108IFG nitrite reductase, (NAD(P)H) BMWSH_4096 ENOG4105C6Z Gluconate BMWSH_4098 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BMWSH_4100 ENOG4105CBC glutamate synthase BMWSH_4103 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BMWSH_4106 ENOG4108KGH TRANSCRIPTIONal BMWSH_4107 ENOG4107YJ4 chain length determinant protein BMWSH_4108 ENOG4105HTX biosynthesis protein BMWSH_4110 ENOG4105DG6 mannose-6-phosphate isomerase BMWSH_4111 ENOG4105C6Y Udp-glucose 6-dehydrogenase BMWSH_4113 ENOG4105CJR Integral membrane protein (MviN BMWSH_4114 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BMWSH_4115 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BMWSH_4117 ENOG4105D3Q Sugar transferase BMWSH_4118 ENOG4105EXC Acyl-transferase BMWSH_4120 ENOG4105D3Q Sugar transferase BMWSH_4123 ENOG4105DQ6 Transposase BMWSH_4124 ENOG4105CTM Glycoside hydrolase family 5 BMWSH_4129 ENOG4108IMY Transcriptional regulator BMWSH_4132 ENOG4107RVV histidinol phosphate phosphatase, hisj family BMWSH_4137 ENOG4105I03 Flagellin BMWSH_4141 ENOG4105PNM synthesis protein BMWSH_4145 ENOG4105BZU Histidine kinase BMWSH_4148 ENOG4108JU3 Alkyl hydroperoxide reductase BMWSH_4149 ENOG4105EUJ GTP cyclohydrolase i BMWSH_4150 ENOG4105BZU Histidine kinase BMWSH_4152 ENOG4105BZ1 (ABC) transporter BMWSH_4155 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BMWSH_4163 ENOG41082BM Transcriptional regulator, arsr family BMWSH_4165 ENOG4105D7V transposase BMWSH_4166 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMWSH_4168 ENOG4108JPW Aminotransferase BMWSH_4172 ENOG4105DTQ mandelate racemase muconate lactonizing BMWSH_4177 ENOG4105CV8 reductase BMWSH_4178 ENOG4105JFG SpoIID LytB domain protein BMWSH_4187 ENOG4105E1V na solute symporter BMWSH_4188 ENOG4106CAD Protein of unknown function (DUF3311) BMWSH_4189 ENOG4105C09 Bile acid BMWSH_4190 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BMWSH_4191 ENOG4105CSC Glucose uptake protein BMWSH_4192 ENOG4105KVH Transcriptional regulator BMWSH_4193 ENOG4105BZU Histidine kinase BMWSH_4205 ENOG4105CMR udp-glucose 4-epimerase BMWSH_4207 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BMWSH_4210 ENOG4105CPC Aldo Keto reductase BMWSH_4212 ENOG4108WAV Transcriptional regulator BMWSH_4213 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BMWSH_4215 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BMWSH_4218 ENOG4105E66 phosphoriboisomerase A BMWSH_4220 ENOG4106ETB IIa component BMWSH_4221 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BMWSH_4222 ENOG4105RD7 BadF BadG BcrA BcrD BMWSH_4224 ENOG4105VCP PTS System BMWSH_4226 ENOG4105F8D glycoside hydrolase family 4 BMWSH_4230 ENOG4106KNT transcriptional regulator BMWSH_4231 ENOG4105F32 YngK protein BMWSH_4246 ENOG4105KPY Small multidrug resistance protein BMWSH_4247 ENOG4105KPY Small multidrug resistance protein BMWSH_4248 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BMWSH_4254 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BMWSH_4255 ENOG4105D3R alkyl hydroperoxide reductase BMWSH_4256 ENOG4105EE0 oxidoreductase BMWSH_4257 ENOG4108RYK Nad-dependent epimerase dehydratase BMWSH_4258 ENOG4105VEQ Cold shock protein BMWSH_4259 ENOG4105DZC cytosine deaminase BMWSH_4260 ENOG4105CUB amino acid BMWSH_4263 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BMWSH_4267 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BMWSH_4268 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BMWSH_4270 ENOG4105E2X shikimate dehydrogenase BMWSH_4272 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BMWSH_4274 ENOG4106F5Q Membrane BMWSH_4275 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase BMWSH_4279 ENOG4108UT2 hemolysin iii BMWSH_4280 ENOG4105C5A transporter BMWSH_4281 ENOG4105E7W lamb ycsf family protein BMWSH_4283 ENOG4105P4J Allophanate hydrolase, subunit 1 BMWSH_4285 ENOG4107414 GntR family transcriptional regulator BMWSH_4286 ENOG4105CG3 alpha amylase, catalytic region BMWSH_4287 ENOG4105C5Y PTS System BMWSH_4289 ENOG4105FF2 Type I DHQase BMWSH_4292 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BMWSH_4293 ENOG4105ETE Transcriptional regulator (LacI family BMWSH_4294 ENOG4105C7N Xanthine uracil vitamin C permease BMWSH_4295 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BMWSH_4298 ENOG4108JPW Aminotransferase BMWSH_4300 ENOG4106HB6 Alpha beta hydrolase BMWSH_4302 ENOG4105BZU Histidine kinase BMWSH_4303 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMWSH_4305 ENOG4107QJZ Glycosyl transferase, family 2 BMWSH_4307 ENOG4105BZU Histidine kinase BMWSH_4315 ENOG4107XC4 flavin reductase domain protein, FMN-binding BMWSH_4316 ENOG41069ER domain protein BMWSH_4317 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BMWSH_4318 ENOG4105CNN ABC, transporter BMWSH_4319 ENOG4105C2J ABC transporter BMWSH_4320 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BMWSH_4321 ENOG4108RVA ribokinase BMWSH_4322 ENOG4105ETE Transcriptional regulator (LacI family BMWSH_4325 ENOG4105CS1 NAD(P)H quinone oxidoreductase BMWSH_4326 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMWSH_4327 ENOG4105CW7 secretion protein, HlyD family BMWSH_4328 ENOG41067TZ transcriptional regulator, MarR family BMWSH_4329 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BMWSH_4331 ENOG4107HP6 Transcriptional regulator BMWSH_4332 ENOG4105MI2 BMWSH_4336 ENOG4105BZ1 (ABC) transporter BMWSH_4337 ENOG4105BZ1 (ABC) transporter BMWSH_4339 ENOG4105KVH Transcriptional regulator BMWSH_4340 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BMWSH_4342 ENOG4105ECB domain protein BMWSH_4349 ENOG4105KVH Transcriptional regulator BMWSH_4350 ENOG4108VA3 3-hexulose-6-phosphate synthase BMWSH_4351 ENOG41080HJ 6-phospho 3-hexuloisomerase BMWSH_4355 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BMWSH_4357 ENOG4105ETU transcriptional activator (TenA BMWSH_4360 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BMWSH_4365 ENOG4108U1V ABC transporter, permease BMWSH_4366 ENOG4105DQ5 transport system permease protein BMWSH_4367 ENOG4108HUF Transporter BMWSH_4368 ENOG4107T8P acyl-Coa dehydrogenase BMWSH_4369 ENOG4105FBW Monooxygenase BMWSH_4370 ENOG4107T8P acyl-Coa dehydrogenase BMWSH_4372 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BMWSH_4373 ENOG4108UMI ABC transporter, permease BMWSH_4374 ENOG4105D01 (LipO)protein BMWSH_4375 ENOG4107YBY Hydrolase BMWSH_4376 ENOG4105CUB amino acid BMWSH_4378 ENOG4105C8Y Acetylornithine aminotransferase BMWSH_4379 ENOG4105C26 Dehydrogenase BMWSH_4383 ENOG4108IJ7 Glycine betaine BMWSH_4384 ENOG4107SQ8 Glycine betaine BMWSH_4385 ENOG41089UC methyltransferase, type 11 BMWSH_4386 ENOG4108KK1 membrane protein AbrB duplication BMWSH_4387 ENOG4108KAM Transcriptional regulator BMWSH_4389 ENOG4108MRH transcriptional regulatory protein BMWSH_4391 ENOG4105D4T Citrate transporter BMWSH_4394 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BMWSH_4395 ENOG4108J5H Homocysteine s-methyltransferase BMWSH_4396 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BMWSH_4399 ENOG4105E0M Sulfatase BMWSH_4401 ENOG4105VZ8 Transcriptional regulator BMWSH_4402 ENOG4107D63 BMWSH_4406 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BMWSH_4407 ENOG4105CSC Glucose uptake protein BMWSH_4408 ENOG4108MRH transcriptional regulatory protein BMWSH_4409 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BMWSH_4410 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BMWSH_4411 ENOG4107QJT sodium dicarboxylate symporter BMWSH_4413 ENOG4108ZCF integral membrane protein BMWSH_4416 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BMWSH_4417 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BMWSH_4419 ENOG4108IQI permease BMWSH_4423 ENOG4105EEI dihydropteroate synthase BMWSH_4425 ENOG4107RBB ABC transporter, permease BMWSH_4426 ENOG4105C19 ABC transporter BMWSH_4427 ENOG4107X8C Efflux transporter RND family MFP subunit BMWSH_4430 ENOG4108IXI (ABC) transporter BMWSH_4431 ENOG4105C4B ABC transporter, permease BMWSH_4435 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BMWSH_4437 ENOG4108S4H thioesterase Superfamily protein BMWSH_4440 ENOG4107QTZ amino acid BMWSH_4441 ENOG4105Q95 Cupin 2, conserved barrel domain protein BMWSH_4443 ENOG4105E1V na solute symporter BMWSH_4445 ENOG4105CSV Glutaminase BMWSH_4448 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) BMWSH_4452 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BMWSH_4453 ENOG4105F27 Major Facilitator BMWSH_4454 ENOG4105KVH Transcriptional regulator BMWSH_4460 ENOG4107FQX Alpha-acetolactate decarboxylase BMWSH_4462 ENOG4107STF Involved in phosphonate degradation (By similarity) BMWSH_4463 ENOG4105DTI Phosphonopyruvate decarboxylase BMWSH_4465 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BMWSH_4469 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BMWSH_4471 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BMWSH_4472 ENOG4108IFG nitrite reductase, (NAD(P)H) BMWSH_4474 ENOG41067MG lrgb family BMWSH_4475 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) BMWSH_4476 ENOG4105DY9 regulatoR BMWSH_4477 ENOG4108HRK Histidine kinase BMWSH_4478 ENOG4105F8D glycoside hydrolase family 4 BMWSH_4479 ENOG4105VCP PTS System BMWSH_4480 ENOG4105CK1 PTS System BMWSH_4481 ENOG4105VZJ PTS System BMWSH_4482 ENOG4105EMD TRANSCRIPTIONal BMWSH_4484 ENOG4108W8B Beta-lactamase domain protein BMWSH_4486 ENOG4105C85 amino acid BMWSH_4488 ENOG4106N3A copper homeostasis protein cutc BMWSH_4489 ENOG4105C1J atp-dependent rna helicase BMWSH_4492 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BMWSH_4496 ENOG4105C6Z Gluconate BMWSH_4497 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BMWSH_4498 ENOG4105CMG Carbohydrate kinase BMWSH_4500 ENOG4106KNT transcriptional regulator BMWSH_4506 ENOG4108ZMI UPF0477 protein BMWSH_4508 ENOG4105H67 Protein of unknown function (DUF421) BMWSH_4510 ENOG4105ENA helicase BMWSH_4522 ENOG4105CJW magnesium transporter BMWSH_4523 ENOG4107S1Q Phosphatase BMWSH_4524 ENOG4105EMS pseudouridine synthase BMWSH_4525 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BMWSH_4528 ENOG4105MIX Adenylate cyclase BMWSH_4529 ENOG4105E4C Lytic transglycosylase catalytic BMWSH_4530 ENOG4108Z18 K06886 hemoglobin BMWSH_4531 ENOG4105T58 Dithiol-disulfide isomerase BMWSH_4533 ENOG4105DPN Oligoendopeptidase f BMWSH_4535 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BMWSH_4537 ENOG4108ZCF integral membrane protein BMWSH_4540 ENOG4107RSM transcriptional regulator BMWSH_4541 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BMWSH_4542 ENOG4105D5Q Arginine ornithine antiporter BMWSH_4543 ENOG4105C85 amino acid BMWSH_4545 ENOG4108JQ7 (ABC) transporter BMWSH_4547 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BMWSH_4548 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BMWSH_4549 ENOG4108J59 Extracellular solute-binding protein, family 5 BMWSH_4550 ENOG4105C31 Tryptophanyl-tRNA synthetase BMWSH_4551 ENOG4108KU1 UPF0736 protein BMWSH_4555 ENOG4108JQ7 (ABC) transporter BMWSH_4556 ENOG4105C3U ABC transporter BMWSH_4558 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BMWSH_4559 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BMWSH_4565 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BMWSH_4566 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BMWSH_4567 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BMWSH_4570 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BMWSH_4573 ENOG4105DBV ornithine carbamoyltransferase BMWSH_4577 ENOG4105CAS nag kinase BMWSH_4578 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BMWSH_4579 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BMWSH_4580 ENOG4107V6Q Cyclic nucleotide-binding domain BMWSH_4581 ENOG4105VG1 fes assembly suf system protein BMWSH_4582 ENOG4108KP7 hydrolase BMWSH_4585 ENOG4107AYK membrAne BMWSH_4586 ENOG4105EPR degv family BMWSH_4588 ENOG4105QNR S1 RNA binding domain protein BMWSH_4589 ENOG4108VPT UPF0234 protein BMWSH_4590 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BMWSH_4591 ENOG4108JUB Transcriptional regulator BMWSH_4595 ENOG4105C8Y Acetylornithine aminotransferase BMWSH_4596 ENOG4105C26 Dehydrogenase BMWSH_4597 ENOG4105FKQ transcriptional regulator BMWSH_4598 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BMWSH_4601 ENOG4108YZA Nitrogen regulatory protein pii BMWSH_4604 ENOG4105CAQ asparagine synthetase BMWSH_4606 ENOG4105YHS UPF0344 protein BMWSH_4615 ENOG4105EYH Exonuclease BMWSH_4617 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BMWSH_4619 ENOG4105CHR reductase BMWSH_4621 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BMWSH_4624 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BMWSH_4625 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BMWSH_4627 ENOG4105E39 Enoyl-CoA hydratase BMWSH_4628 ENOG4105CEY Amp-dependent synthetase and ligase BMWSH_4629 ENOG4105DF9 Lipoate-protein, ligase BMWSH_4630 ENOG4108RQ5 Beta-lactamase domain-containing protein BMWSH_4632 ENOG4105C2F Histidine kinase BMWSH_4634 ENOG4107RF6 penicillin-binding protein BMWSH_4636 ENOG4105C1Q protoporphyrinogen oxidase BMWSH_4637 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BMWSH_4638 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BMWSH_4639 ENOG4105BZ4 penicillin-binding protein BMWSH_4640 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BMWSH_4642 ENOG410841Q phosphoesterase PA-phosphatase related protein BMWSH_4647 ENOG4105K59 histidine triad (HIT) protein BMWSH_4648 ENOG4105EXC Acyl-transferase BMWSH_4649 ENOG4107YB6 acetyltransferase, (GNAT) family BMWSH_4650 ENOG4105U3E Transcriptional regulator BMWSH_4651 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BMWSH_4652 ENOG4105NBU tryptophan transport protein BMWSH_4654 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) BMWSH_4657 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BMWSH_4659 ENOG4105EQI Metal Dependent Phosphohydrolase BMWSH_4660 ENOG4105RHA ABC transporter, permease BMWSH_4661 ENOG4108IUX (ABC) transporter BMWSH_4663 ENOG4105K70 DNA-binding protein BMWSH_4664 ENOG4105CGU Enoyl-CoA hydratase BMWSH_4665 ENOG4105CEY Amp-dependent synthetase and ligase BMWSH_4666 ENOG4105D4P Coproporphyrinogen iii oxidase BMWSH_4668 ENOG4105WZB UPF0342 protein BMWSH_4675 ENOG4105YWU small acid-soluble spore protein BMWSH_4680 ENOG4105DWF phosphomethylpyrimidine kinase BMWSH_4681 ENOG4105D06 uba thif-type nad fad binding protein BMWSH_4684 ENOG41080HI glycine oxidase BMWSH_4685 ENOG4108VEU Thiamine monophosphate synthase BMWSH_4692 ENOG4108Z40 Transcriptional regulator BMWSH_4694 ENOG4105ED1 spovr family BMWSH_4699 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BMWSH_4700 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BMWSH_4702 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BMWSH_4704 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BMWSH_4705 ENOG4108PXI ErfK YbiS YcfS YnhG BMWSH_4706 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BMWSH_4707 ENOG4105CK5 oxidoreductase BMWSH_4709 ENOG4108YBP pseudouridine synthase BMWSH_4710 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BMWSH_4712 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BMWSH_4713 ENOG4105DAA L-lactate BMWSH_4714 ENOG4105CB2 alcohol dehydrogenase BMWSH_4720 ENOG4105FR1 rard protein BMWSH_4722 ENOG4108RE7 deoxyribonuclease BMWSH_4725 ENOG4105D4T Citrate transporter BMWSH_4727 ENOG4105DEF Extracellular solute-binding protein, family 5 BMWSH_4728 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BMWSH_4729 ENOG41090U3 tautomerase BMWSH_4733 ENOG4105FE9 pseudouridine synthase BMWSH_4734 ENOG4105C0R drug resistance transporter emrb qaca subfamily BMWSH_4742 ENOG4108JYZ YitT family BMWSH_4746 ENOG4105ETE Transcriptional regulator (LacI family BMWSH_4752 ENOG4105CK5 oxidoreductase BMWSH_4754 ENOG4105IE8 Alpha-ketoglutarate permease BMWSH_4755 ENOG4105ETE Transcriptional regulator (LacI family BMWSH_4757 ENOG4105YWU small acid-soluble spore protein BMWSH_4761 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BMWSH_4762 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BMWSH_4766 ENOG4108VXD carboxy-peptidase BMWSH_4767 ENOG41069ER domain protein BMWSH_4768 ENOG41068JE domain protein BMWSH_4776 ENOG4105DTQ mandelate racemase muconate lactonizing BMWSH_4779 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BMWSH_4782 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component BMWSH_4783 ENOG4108IJ9 (ABC) transporter BMWSH_4784 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BMWSH_4788 ENOG4105CUB amino acid BMWSH_4790 ENOG4105EU9 BMWSH_4791 ENOG4107T5V SNARE associated Golgi BMWSH_4792 ENOG4108REF Sporulation integral membrane protein ytvi BMWSH_4794 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BMWSH_4796 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BMWSH_4799 ENOG41076HS cation diffusion facilitator family transporter BMWSH_4801 ENOG4106AKX UPF0229 protein BMWSH_4802 ENOG4105CYN Serine protein kinase BMWSH_4804 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BMWSH_4806 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BMWSH_4809 ENOG4105TUA UPF0295 protein BMWSH_4810 ENOG4105G5W regulator Fur family BMWSH_4811 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BMWSH_4815 ENOG4108IUW ABC transporter BMWSH_4816 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BMWSH_4817 ENOG4107NBY Membrane BMWSH_4818 ENOG4105BZ1 (ABC) transporter BMWSH_4819 ENOG4105EVI UPF0374 protein BMWSH_4822 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BMWSH_4823 ENOG4106BXE BMWSH_4824 ENOG4105CEN a g-specific adenine glycosylase BMWSH_4825 ENOG41067AE Membrane-bound metal-dependent hydrolase BMWSH_4827 ENOG4105XHU Acid-soluble spore protein K BMWSH_4829 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr BMWSH_4831 ENOG4105ECP epimerase BMWSH_4835 ENOG4105BZU Histidine kinase BMWSH_4837 ENOG4105C85 amino acid BMWSH_4838 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BMWSH_4845 ENOG4105UPD Calcium Proton BMWSH_4846 ENOG410606W general stress protein BMWSH_4848 ENOG4105PY6 Phenolic acid decarboxylase BMWSH_4849 ENOG4105NI3 Protein of unknown function (DUF3237) BMWSH_4850 ENOG4108ISG Major Facilitator BMWSH_4851 ENOG4105PGM cation diffusion facilitator family transporter BMWSH_4852 ENOG4105KTU Transcriptional regulator, arsr family BMWSH_4854 ENOG4105C59 p-type ATPase BMWSH_4856 ENOG4107U9T Pfam:Ribonuclease_BN BMWSH_4858 ENOG4105KJF protein tyrosine phosphatase BMWSH_4860 ENOG4105CPN adenine deaminase BMWSH_4862 ENOG4105K4I Scp-like extracellular BMWSH_4863 ENOG4108Z0Z intracellular protease Pfpi family BMWSH_4864 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) BMWSH_4865 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BMWSH_4866 ENOG4105KPV Transcriptional regulator BMWSH_4869 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase BMWSH_4870 ENOG4105C5H ABC transporter BMWSH_4873 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BMWSH_4875 ENOG4108K8S endonuclease I BMWSH_4884 ENOG4108IBT Inherit from COG: transposase BMWSH_4886 ENOG4105FDU atp-dependent rna helicase BMWSH_4887 ENOG4105BZU Histidine kinase BMWSH_4890 ENOG4108MRH transcriptional regulatory protein BMWSH_4892 ENOG4105D7N magnesium and cobalt transport protein CorA BMWSH_4896 ENOG4105BZG amino acid carrier protein BMWSH_4898 ENOG4106DF1 BMWSH_4900 ENOG4107R7Y intracellular protease Pfpi family BMWSH_4905 ENOG4108ZHJ Organic hydroperoxide resistance protein BMWSH_4906 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BMWSH_4910 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BMWSH_4912 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMWSH_4913 ENOG41062D9 Histidine kinase BMWSH_4916 ENOG4106BRA Membrane BMWSH_4918 ENOG4105DRP amino acid AbC transporter BMWSH_4919 ENOG4105EAD ABC transporter BMWSH_4923 ENOG4105C2C drug resistance transporter, Bcr CflA BMWSH_4924 ENOG4108Z5V transcriptional regulator, merr family BMWSH_4925 ENOG4107QWG 2-Nitropropane dioxygenase BMWSH_4926 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BMWSH_4927 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BMWSH_4928 ENOG4105BZU Histidine kinase BMWSH_4929 ENOG4107RMD Basic membrane lipoprotein BMWSH_4933 ENOG4107AYK membrAne BMWSH_4935 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BMWSH_4936 ENOG4105CBD Diacylglycerol kinase BMWSH_4937 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BMWSH_4938 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BMWSH_4939 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BMWSH_4943 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BMWSH_4944 ENOG4105C4R Atp-dependent dna helicase BMWSH_4946 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BMWSH_4947 ENOG4105KGF protein, YerC YecD BMWSH_4949 ENOG4108V3E phosphoribosylglycinamide formyltransferase BMWSH_4950 ENOG4105CXB phosphoribosylaminoimidazole synthetase BMWSH_4952 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BMWSH_4953 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BMWSH_4954 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BMWSH_4955 ENOG4105C8V SAICAR synthetase BMWSH_4956 ENOG4105C83 adenylosuccinate lyase BMWSH_4957 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BMWSH_4958 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BMWSH_4960 ENOG41067KS pro-sigma K processing BMWSH_4962 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BMWSH_4963 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BMWSH_4964 ENOG4105C6E dna polymerase iii BMWSH_4965 ENOG4108Z6B deaminase BMWSH_4966 ENOG4105GTG Isochorismatase BMWSH_4967 ENOG4105VRS hydrolase family 18 BMWSH_4969 ENOG4105ZMH deoxynucleoside kinase BMWSH_4971 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BMWSH_4972 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BMWSH_4974 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BMWSH_4976 ENOG4105C7N Xanthine uracil vitamin C permease BMWSH_4977 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BMWSH_4980 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BMWSH_4981 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BMWSH_4982 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BMWSH_4983 ENOG4108TYN CAAX amino terminal protease family protein BMWSH_4985 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BMWSH_4986 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BMWSH_4987 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BMWSH_4988 ENOG4105C5H ABC transporter BMWSH_4989 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BMWSH_4990 ENOG410801F ribosomal-protein-alanine acetyltransferase BMWSH_4991 ENOG41072GX Peptidase M22 Glycoprotease BMWSH_4992 ENOG4105K8N protein family UPF0079, ATPase BMWSH_4996 ENOG41064BQ Phosphatase BMWSH_5000 ENOG4107SGM protein serine threonine phosphatase BMWSH_5001 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BMWSH_5002 ENOG4105FUA antagonist BMWSH_5003 ENOG4107MMM Anti-sigma-factor antagonist BMWSH_5004 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BMWSH_5006 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BMWSH_5007 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BMWSH_5008 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BMWSH_5011 ENOG4105C1J atp-dependent rna helicase BMWSH_5012 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BMWSH_5013 ENOG4105CPF Cell wall formation (By similarity) BMWSH_5015 ENOG4105I7V membrAne BMWSH_5016 ENOG41081YB ApbE family BMWSH_5018 ENOG4105US7 Histidine kinase BMWSH_5020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BMWSH_5021 ENOG4105D38 putrescine abc transporter BMWSH_5022 ENOG4105F38 ABC transporter, permease BMWSH_5025 ENOG4107T7U Sulfatase BMWSH_5026 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BMWSH_5027 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BMWSH_5029 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BMWSH_5030 ENOG4105ETD TRANSCRIPTIONal BMWSH_5031 ENOG4105CTS PTS system mannitol-specific BMWSH_5033 ENOG4105K4H Nlp p60 protein BMWSH_5036 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BMWSH_5037 ENOG4105C8B TIGR00159 family BMWSH_5039 ENOG4105EMN RNA polymerase sigma factor BMWSH_5043 ENOG4108NMV polysaccharide deacetylase BMWSH_5046 ENOG4108KSA LysR family transcriptional regulator BMWSH_5047 ENOG4105D1F ATP-binding protein BMWSH_5058 ENOG4108F3G Type I restriction-modification system, R subunit BMWSH_5064 ENOG4105VTR Integrase BMWSH_5066 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BMWSH_5067 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BMWSH_5068 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BMWSH_5069 ENOG4108JJB ABC transporter BMWSH_5070 ENOG4108JJB ABC transporter BMWSH_5071 ENOG4108ZT0 50S ribosomal protein l17 BMWSH_5072 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BMWSH_5074 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BMWSH_5076 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BMWSH_5077 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BMWSH_5078 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BMWSH_5079 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BMWSH_5080 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BMWSH_5081 ENOG4105VPB 50S ribosomal protein L30 BMWSH_5082 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BMWSH_5084 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BMWSH_5085 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BMWSH_5086 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BMWSH_5089 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BMWSH_5090 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BMWSH_5091 ENOG41082SA 50s ribosomal protein l29 BMWSH_5092 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BMWSH_5093 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BMWSH_5094 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BMWSH_5095 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BMWSH_5096 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BMWSH_5097 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BMWSH_5098 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BMWSH_5099 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BMWSH_5101 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BMWSH_5103 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BMWSH_5104 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BMWSH_5105 ENOG4105XPM ribosomal protein BMWSH_5107 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BMWSH_5108 ENOG4107Y49 methyltransferase BMWSH_5109 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BMWSH_5110 ENOG4108VZM 50s ribosomal protein L10 BMWSH_5111 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BMWSH_5113 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BMWSH_5114 ENOG41087NY 50S ribosomal protein L33 BMWSH_5115 ENOG4105QIV RNA polymerase BMWSH_5116 ENOG4105M0M Tetracycline resistance protein BMWSH_5117 ENOG4105C2N RNA methyltransferase TrmH family group 3 BMWSH_5119 ENOG4105C8N cysteinyl-tRNA synthetase BMWSH_5120 ENOG4105D7W serine acetyltransferase BMWSH_5121 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BMWSH_5122 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BMWSH_5123 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BMWSH_5124 ENOG4105CTP PilT protein domain protein BMWSH_5125 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BMWSH_5126 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BMWSH_5128 ENOG41066A3 ATP guanido phosphotransferase BMWSH_5129 ENOG4108Z0C Uvrb UvrC protein BMWSH_5131 ENOG4105CRK lysyL-tRNA synthetase BMWSH_5132 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BMWSH_5133 ENOG4105KRF dihydroneopterin aldolase BMWSH_5134 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BMWSH_5135 ENOG4105DDQ anthranilate synthase BMWSH_5136 ENOG4105CRQ synthase (Component I) BMWSH_5137 ENOG4105C6T cysteine synthase BMWSH_5138 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BMWSH_5139 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BMWSH_5140 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BMWSH_5141 ENOG4108UGV hypoxanthine phosphoribosyltransferase BMWSH_5142 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BMWSH_5145 ENOG4105G3A stage ii sporulation protein e BMWSH_5146 ENOG41060GV RNA binding s1 domain protein BMWSH_5147 ENOG41060GV RNA binding s1 domain protein BMWSH_5151 ENOG4105VYY sporulation protein yabp BMWSH_5152 ENOG41082I2 s4 domain protein BMWSH_5153 ENOG4108IY2 MazG family BMWSH_5155 ENOG4108M14 stage v sporulation protein t BMWSH_5156 ENOG4108JA2 transcriptioN-repair coupling factor BMWSH_5158 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BMWSH_5159 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BMWSH_5160 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BMWSH_5161 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BMWSH_5162 ENOG4105K4W Could be involved in septation (By similarity) BMWSH_5163 ENOG4105KME endoribonuclease L-psp BMWSH_5164 ENOG4105DFT pur operon repressor BMWSH_5168 ENOG4105W42 Veg protein BMWSH_5170 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BMWSH_5171 ENOG4105F8V Hydrolase, tatD family BMWSH_5172 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BMWSH_5173 ENOG4105VC4 domain protein BMWSH_5174 ENOG41060K3 Methyltransferase BMWSH_5175 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) BMWSH_5176 ENOG4105MA4 psp1 domain protein BMWSH_5177 ENOG4105FA2 dna polymerase iii BMWSH_5178 ENOG4105X0R protein from nitrogen regulatory protein P-II BMWSH_5179 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BMWSH_5180 ENOG4105CXN decarboxylase BMWSH_5181 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BMWSH_5182 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BMWSH_5184 ENOG410848D S4 domain protein YaaA BMWSH_5185 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BMWSH_5186 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BMWSH_p10035 ENOG4105CPK Glycosyl transferase (Group 1 BMWSH_p10044 ENOG4105K64 Glycosyl transferase, family 2 BMWSH_p10047 ENOG4105K64 Glycosyl transferase, family 2 BMWSH_p10051 ENOG4105K64 Glycosyl transferase, family 2 BMWSH_p10058 ENOG4105C5E polysaccharide biosynthesis protein BMWSH_p10059 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BMWSH_p10069 ENOG4105DNP FAD linked oxidase domain protein BMWSH_p201 ENOG4105K63 Thioredoxin BMWSH_p209 ENOG4105K7K Transcriptional regulator BMWSH_p211 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin