locus-tag	class	description
C0971_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C0971_00010	COG0592	DNA-directed DNA polymerase activity
C0971_00015	COG2501	S4 domain
C0971_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0971_00025	COG0187	DNA topoisomerase II activity
C0971_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C0971_00070	COG0516	GMP reductase activity
C0971_00070	COG0517	IMP dehydrogenase activity
C0971_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C0971_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0971_00100	COG1428	Deoxynucleoside kinase
C0971_00105	COG1428	Deoxynucleoside kinase
C0971_00110	COG1388	LysM domain
C0971_00110	COG3858	chitin binding
C0971_00115	COG0590	tRNA wobble adenosine to inosine editing
C0971_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C0971_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C0971_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0971_00180	COG1982	Orn Lys Arg decarboxylase major
C0971_00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C0971_00190	COG3870	Protein conserved in bacteria
C0971_00195	COG1728	Protein conserved in bacteria
C0971_00200	COG0470	DNA polymerase III
C0971_00205	COG1774	PSP1 C-terminal conserved region
C0971_00210	COG4467	Involved in initiation control of chromosome replication
C0971_00215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C0971_00220	COG2827	Endonuclease containing a URI domain
C0971_00225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C0971_00230	COG2002	toxin-antitoxin pair type II binding
C0971_00240	COG0084	hydrolase, TatD family'
C0971_00245	COG3583	domain protein
C0971_00245	COG3584	3D domain protein
C0971_00255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0971_00265	COG4466	Protein conserved in bacteria
C0971_00280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0971_00285	COG0251	oxidation-reduction process
C0971_00290	COG2088	sporulation resulting in formation of a cellular spore
C0971_00295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0971_00305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C0971_00310	COG0193	aminoacyl-tRNA hydrolase activity
C0971_00320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C0971_00325	COG2002	toxin-antitoxin pair type II binding
C0971_00330	COG2244	polysaccharide biosynthetic process
C0971_00335	COG3956	TIGRFAM MazG family protein
C0971_00340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C0971_00360	COG1098	S1 RNA binding domain
C0971_00370	COG2208	phosphoserine phosphatase activity
C0971_00375	COG2304	oxidoreductase activity
C0971_00380	COG0515	serine threonine protein kinase
C0971_00390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C0971_00395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0971_00400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C0971_00405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C0971_00410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0971_00415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0971_00420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C0971_00425	COG0512	Glutamine amidotransferase of anthranilate synthase
C0971_00430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0971_00435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C0971_00440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C0971_00445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C0971_00450	COG1396	sequence-specific DNA binding
C0971_00455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C0971_00545	COG3880	PFAM UvrB UvrC protein
C0971_00550	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C0971_00555	COG0542	response to heat
C0971_00560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C0971_00565	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C0971_00570	COG4956	integral membrane protein (PIN domain superfamily)
C0971_00580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C0971_00585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0971_00590	COG1045	serine acetyltransferase
C0971_00595	COG0215	cysteine-tRNA ligase activity
C0971_00605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0971_00610	COG3688	RNA-binding protein containing a PIN domain
C0971_00620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0971_00625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0971_00630	COG0250	Participates in transcription elongation, termination and antitermination
C0971_00635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0971_00640	COG0081	regulation of translation
C0971_00645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C0971_00650	COG0222	ribosome binding
C0971_00655	COG2813	Specifically methylates the guanine in position
C0971_00660	COG0085	RNA polymerase activity
C0971_00665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0971_00670	COG1358	cellular component organization or biogenesis
C0971_00675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0971_00680	COG0049	tRNA binding
C0971_00685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C0971_00690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0971_00695	COG0051	transcription antitermination factor activity, RNA binding
C0971_00700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C0971_00705	COG0088	Forms part of the polypeptide exit tunnel
C0971_00715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C0971_00720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C0971_00725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C0971_00730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C0971_00735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C0971_00740	COG0255	Belongs to the universal ribosomal protein uL29 family
C0971_00750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C0971_00755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C0971_00775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C0971_00780	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C0971_00785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C0971_00790	COG1841	ribosomal large subunit assembly
C0971_00800	COG0201	protein transport
C0971_00805	COG0563	adenylate kinase activity
C0971_00810	COG0024	Methionine aminopeptidase
C0971_00815	COG2163	COG2163 Ribosomal protein L14E L6E L27E
C0971_00820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C0971_00825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C0971_00830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C0971_00835	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C0971_00845	COG0203	ribosomal protein L17
C0971_00850	COG1122	ATPase activity
C0971_00855	COG1122	ATPase activity
C0971_00860	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C0971_00875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0971_00880	COG0582	viral genome integration into host DNA
C0971_00895	COG2855	membrane
C0971_00900	COG0583	DNA-binding transcription factor activity
C0971_00935	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0971_00940	COG0489	protein tyrosine kinase activity
C0971_00950	COG2194	sulfuric ester hydrolase activity
C0971_00955	COG0726	polysaccharide deacetylase
C0971_01050	COG1595	DNA-templated transcription, initiation
C0971_01055	COG5662	AntiSigma factor
C0971_01060	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C0971_01065	COG4856	YbbR-like protein
C0971_01070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0971_01075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0971_01080	COG1113	amino acid transport
C0971_01105	COG1132	(ABC) transporter
C0971_01115	COG2267	carboxylic ester hydrolase activity
C0971_01125	COG3711	transcriptional antiterminator
C0971_01140	COG0346	lactoylglutathione lyase activity
C0971_01150	COG0352	thiamine-phosphate diphosphorylase activity
C0971_01155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0971_01165	COG2022	thiamine diphosphate biosynthetic process
C0971_01170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C0971_01180	COG1070	Carbohydrate kinase
C0971_01195	COG1174	glycine betaine transport
C0971_01200	COG0517	IMP dehydrogenase activity
C0971_01200	COG1125	glycine betaine transport
C0971_01205	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C0971_01220	COG0531	amino acid
C0971_01225	COG2135	peptidase activity
C0971_01230	COG2239	Acts as a magnesium transporter
C0971_01240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0971_01245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0971_01250	COG1120	ATPase activity
C0971_01255	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C0971_01270	COG1492	cobalamin metabolic process
C0971_01275	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C0971_01290	COG2096	Adenosyltransferase
C0971_01320	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0971_01325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C0971_01335	COG0513	Belongs to the DEAD box helicase family
C0971_01340	COG3402	PFAM membrane-flanked domain
C0971_01345	COG3428	Bacterial PH domain
C0971_01350	COG0705	Rhomboid family
C0971_01355	COG0736	holo-[acyl-carrier-protein] synthase activity
C0971_01360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C0971_01365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0971_01375	COG0864	Transcriptional regulator
C0971_01380	COG2337	Toxic component of a toxin-antitoxin (TA) module
C0971_01385	COG1366	Belongs to the anti-sigma-factor antagonist family
C0971_01390	COG1366	Belongs to the anti-sigma-factor antagonist family
C0971_01395	COG2172	sigma factor antagonist activity
C0971_01400	COG2208	phosphoserine phosphatase activity
C0971_01405	COG1366	Belongs to the anti-sigma-factor antagonist family
C0971_01415	COG1191	sigma factor activity
C0971_01420	COG2208	phosphoserine phosphatase activity
C0971_01425	COG2183	response to ionizing radiation
C0971_01435	COG3091	SprT-like family
C0971_01525	COG0802	atpase or kinase
C0971_01530	COG1214	PFAM Peptidase M22, glycoprotease
C0971_01535	COG0456	acetyltransferase
C0971_01545	COG0488	(ABC) transporter
C0971_01550	COG0315	cyclic pyranopterin monophosphate synthase activity
C0971_01555	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C0971_01565	COG1266	CAAX protease self-immunity
C0971_01570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C0971_01575	COG0459	protein refolding
C0971_01615	COG2304	oxidoreductase activity
C0971_01625	COG0463	Glycosyl transferase, family 2
C0971_01635	COG0714	Associated with various cellular activities
C0971_01640	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C0971_01645	COG1305	Transglutaminase-like
C0971_01650	COG0519	Catalyzes the synthesis of GMP from XMP
C0971_01650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0971_01655	COG2252	PERMEase
C0971_01660	COG3711	transcriptional antiterminator
C0971_01665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0971_01665	COG1263	PTS System
C0971_01665	COG2190	(PTS) system
C0971_01695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C0971_01700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C0971_01705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0971_01710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0971_01715	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0971_01720	COG0047	phosphoribosylformylglycinamidine synthase activity
C0971_01725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0971_01730	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C0971_01735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0971_01740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C0971_01745	COG0138	bifunctional purine biosynthesis protein purh
C0971_01750	COG0151	Belongs to the GarS family
C0971_01765	COG1470	cell adhesion involved in biofilm formation
C0971_01770	COG4496	protein, YerC YecD
C0971_01775	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C0971_01780	COG0210	DNA helicase
C0971_01785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0971_01790	COG4851	CamS sex pheromone cAM373 precursor
C0971_01795	COG1012	belongs to the aldehyde dehydrogenase family
C0971_01800	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C0971_01805	COG2224	Isocitrate lyase
C0971_01815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0971_01820	COG0154	amidase activity
C0971_01850	COG0789	Transcriptional regulator
C0971_01855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C0971_01860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0971_01870	COG1968	undecaprenyl-diphosphatase activity
C0971_01875	COG1597	lipid kinase activity
C0971_01880	COG1404	Belongs to the peptidase S8 family
C0971_01885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C0971_01895	COG0183	Belongs to the thiolase family
C0971_01900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0971_01905	COG1960	acyl-CoA dehydrogenase activity
C0971_01910	COG1464	Belongs to the NlpA lipoprotein family
C0971_01915	COG0531	amino acid
C0971_01920	COG3540	Alkaline phosphatase
C0971_01945	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C0971_01965	COG0579	oxidoreductase
C0971_01990	COG0583	DNA-binding transcription factor activity
C0971_01995	COG0070	glutamate synthase
C0971_01995	COG0069	glutamate synthase activity
C0971_01995	COG0067	glutamate synthase
C0971_02000	COG0493	'glutamate synthase
C0971_02015	COG1278	Cold shock
C0971_02020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0971_02025	COG2814	Major facilitator Superfamily
C0971_02030	COG2720	vancomycin resistance protein
C0971_02035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C0971_02040	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C0971_02045	COG3853	Toxic anion resistance protein (TelA)
C0971_02055	COG4549	nuclear export factor GLE1
C0971_02060	COG1276	copper resistance
C0971_02060	COG2372	response to copper ion
C0971_02090	COG0010	Belongs to the arginase family
C0971_02105	COG0656	L-ascorbic acid biosynthetic process
C0971_02110	COG1309	transcriptional regulator
C0971_02115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0971_02120	COG0765	amino acid transport
C0971_02125	COG1126	abc transporter atp-binding protein
C0971_02150	COG0640	Transcriptional regulator
C0971_02160	COG0346	lactoylglutathione lyase activity
C0971_02165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0971_02170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C0971_02175	COG0640	Transcriptional regulator
C0971_02185	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C0971_02225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0971_02235	COG0805	protein transport
C0971_02240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C0971_02250	COG0523	cobalamin synthesis protein
C0971_02255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0971_02270	COG1755	Isoprenylcysteine carboxyl methyltransferase
C0971_02350	COG0475	glutathione-regulated potassium exporter activity
C0971_02390	COG0004	ammonium transporteR
C0971_02440	COG5577	PFAM Coat F domain
C0971_02470	COG2003	Belongs to the UPF0758 family
C0971_02515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C0971_02535	COG3279	Response regulator of the LytR AlgR family
C0971_02540	COG0318	PFAM AMP-dependent synthetase and ligase
C0971_02550	COG0463	Glycosyl transferase, family 2
C0971_02570	COG1012	belongs to the aldehyde dehydrogenase family
C0971_02590	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C0971_02600	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C0971_02610	COG0375	protein maturation
C0971_02615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C0971_02620	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C0971_02625	COG0298	carbon dioxide binding
C0971_02630	COG0409	Hydrogenase expression formation protein
C0971_02640	COG0671	phosphoesterase, PA-phosphatase related
C0971_02645	COG5002	protein histidine kinase activity
C0971_02650	COG0745	RESPONSE REGULATOR receiver
C0971_02665	COG1151	hydroxylamine reductase activity
C0971_02675	COG0651	ATP synthesis coupled electron transport
C0971_02680	COG0650	Formate hydrogenlyase subunit 4
C0971_02685	COG4237	Hydrogenase 4 membrane
C0971_02690	COG0651	ATP synthesis coupled electron transport
C0971_02695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0971_02700	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C0971_02700	COG3261	NADH dehydrogenase
C0971_02705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0971_02710	COG3260	NADH ubiquinone oxidoreductase 20
C0971_02720	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C0971_02725	COG0375	protein maturation
C0971_02730	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C0971_02735	COG1509	lysine 2,3-aminomutase activity
C0971_02760	COG1587	Uroporphyrinogen-III synthase
C0971_02765	COG0175	sulfate reduction
C0971_02770	COG2046	Belongs to the sulfate adenylyltransferase family
C0971_02775	COG0529	Catalyzes the synthesis of activated sulfate
C0971_02780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0971_02800	COG1648	precorrin-2 dehydrogenase activity
C0971_02805	COG0730	response to heat
C0971_02810	COG1388	LysM domain
C0971_02810	COG3584	3D domain protein
C0971_02815	COG1012	belongs to the aldehyde dehydrogenase family
C0971_02815	COG1454	alcohol dehydrogenase
C0971_02820	COG1012	belongs to the aldehyde dehydrogenase family
C0971_02820	COG1454	alcohol dehydrogenase
C0971_02830	COG4336	lyase activity
C0971_02835	COG0310	cobalt ion transport
C0971_02845	COG1122	ATPase activity
C0971_02855	COG0535	radical SAM domain protein
C0971_02870	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C0971_02875	COG1984	allophanate hydrolase subunit 2
C0971_02880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C0971_02885	COG1114	Component of the transport system for branched-chain amino acids
C0971_02905	COG0514	ATP-dependent DNA helicase (RecQ)
C0971_02910	COG3858	chitin binding
C0971_02910	COG1388	LysM domain
C0971_02920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0971_02925	COG0765	amino acid transport
C0971_02935	COG1012	belongs to the aldehyde dehydrogenase family
C0971_02940	COG5002	protein histidine kinase activity
C0971_02965	COG2879	small protein
C0971_02970	COG1966	Carbon starvation protein
C0971_02975	COG2176	DNA-directed DNA polymerase activity
C0971_02985	COG0004	ammonium transporteR
C0971_03000	COG2706	6-phosphogluconolactonase activity
C0971_03010	COG2814	Major facilitator Superfamily
C0971_03035	COG0765	amino acid transport
C0971_03045	COG2966	Psort location CytoplasmicMembrane, score
C0971_03050	COG3610	response to peptide
C0971_03055	COG2207	Transcriptional regulator
C0971_03060	COG1653	transport
C0971_03080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0971_03085	COG3773	Cell wall hydrolase
C0971_03095	COG0573	inorganic phosphate transmembrane transporter activity
C0971_03100	COG0581	inorganic phosphate transmembrane transporter activity
C0971_03105	COG0789	Transcriptional regulator
C0971_03120	COG0346	lactoylglutathione lyase activity
C0971_03145	COG0745	RESPONSE REGULATOR receiver
C0971_03150	COG2205	protein histidine kinase activity
C0971_03165	COG3275	phosphorelay sensor kinase activity
C0971_03175	COG1966	Carbon starvation protein
C0971_03180	COG0531	amino acid
C0971_03185	COG2848	UPF0210 protein
C0971_03190	COG3830	Belongs to the UPF0237 family
C0971_03195	COG0351	phosphomethylpyrimidine kinase
C0971_03205	COG0513	Belongs to the DEAD box helicase family
C0971_03210	COG0626	cystathionine gamma-synthase activity
C0971_03220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0971_03225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_03235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0971_03240	COG0460	homoserine dehydrogenase
C0971_03250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C0971_03275	COG2197	response regulator
C0971_03280	COG3104	oligopeptide transport
C0971_03285	COG2244	polysaccharide biosynthetic process
C0971_03290	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C0971_03295	COG1254	Belongs to the acylphosphatase family
C0971_03300	COG2309	aminopeptidase activity
C0971_03315	COG2080	2 iron, 2 sulfur cluster binding
C0971_03325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0971_03330	COG0789	Transcriptional regulator
C0971_03355	COG5002	protein histidine kinase activity
C0971_03370	COG1842	Phage shock protein A
C0971_03375	COG0494	nUDIX hydrolase
C0971_03380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C0971_03405	COG2986	histidine ammonia-lyase
C0971_03415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0971_03420	COG1360	Flagellar Motor Protein
C0971_03425	COG0024	Methionine aminopeptidase
C0971_03430	COG4840	Belongs to the UPF0435 family
C0971_03440	COG1295	ribonuclease BN
C0971_03445	COG2217	Heavy metal translocating P-type atpase
C0971_03450	COG0477	Major facilitator Superfamily
C0971_03455	COG0387	Pfam Sodium calcium exchanger
C0971_03465	COG0535	radical SAM domain protein
C0971_03480	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C0971_03485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0971_03515	COG0701	Predicted permease
C0971_03520	COG0803	Belongs to the bacterial solute-binding protein 9 family
C0971_03540	COG2226	methyltransferase
C0971_03545	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C0971_03550	COG1228	amidohydrolase
C0971_03555	COG0010	Belongs to the arginase family
C0971_03570	COG1090	epimerase
C0971_03600	COG1988	membrane-bound metal-dependent
C0971_03610	COG1194	a g-specific adenine glycosylase
C0971_03620	COG1028	Short-chain dehydrogenase reductase Sdr
C0971_03640	COG1132	(ABC) transporter
C0971_03650	COG4129	membrane
C0971_03655	COG0070	glutamate synthase
C0971_03655	COG0067	glutamate synthase
C0971_03655	COG0069	glutamate synthase activity
C0971_03660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0971_03665	COG4555	ABC transporter
C0971_03685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C0971_03690	COG0735	belongs to the Fur family
C0971_03800	COG4974	Belongs to the 'phage' integrase family
C0971_03815	COG1715	Restriction endonuclease
C0971_03830	COG4974	Belongs to the 'phage' integrase family
C0971_03845	COG0367	asparagine synthase
C0971_03895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C0971_03900	COG0573	inorganic phosphate transmembrane transporter activity
C0971_03905	COG0581	inorganic phosphate transmembrane transporter activity
C0971_03915	COG3382	B3 4 domain protein
C0971_03920	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C0971_03930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C0971_03935	COG0778	Nitroreductase
C0971_03940	COG2766	serine protein kinase
C0971_03945	COG2718	Belongs to the UPF0229 family
C0971_03950	COG2094	Belongs to the DNA glycosylase MPG family
C0971_03955	COG0628	permease
C0971_03960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0971_03965	COG0306	phosphate transporter
C0971_03970	COG1392	Phosphate transport regulator
C0971_03975	COG0655	NAD(P)H dehydrogenase (quinone) activity
C0971_03980	COG2261	transglycosylase associated protein
C0971_03985	COG0564	pseudouridine synthase activity
C0971_04000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C0971_04005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0971_04020	COG2719	SpoVR family
C0971_04025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0971_04030	COG1271	oxidase subunit
C0971_04035	COG1294	oxidase, subunit
C0971_04040	COG4988	ABC transporter
C0971_04045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C0971_04075	COG1940	carbohydrate kinase activity
C0971_04080	COG0561	phosphatase activity
C0971_04085	COG3689	TIGRFAM TIGR03943 family protein
C0971_04090	COG0701	Predicted permease
C0971_04095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0971_04100	COG0745	RESPONSE REGULATOR receiver
C0971_04105	COG3850	Histidine kinase
C0971_04105	COG5002	protein histidine kinase activity
C0971_04110	COG1368	sulfuric ester hydrolase activity
C0971_04115	COG1253	flavin adenine dinucleotide binding
C0971_04120	COG0789	Transcriptional regulator
C0971_04125	COG1253	flavin adenine dinucleotide binding
C0971_04130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0971_04135	COG3852	Histidine kinase
C0971_04140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C0971_04165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0971_04170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C0971_04175	COG0114	fumarate hydratase activity
C0971_04190	COG3842	ATPase activity
C0971_04195	COG2508	Transcriptional regulator
C0971_04210	COG0189	ligase activity
C0971_04215	COG0189	ligase activity
C0971_04225	COG3679	Belongs to the UPF0342 family
C0971_04230	COG0561	phosphatase activity
C0971_04235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0971_04240	COG0318	PFAM AMP-dependent synthetase and ligase
C0971_04245	COG1024	Enoyl-CoA hydratase
C0971_04255	COG4152	abc transporter atp-binding protein
C0971_04260	COG1668	transmembrane transport
C0971_04265	COG0420	3'-5' exonuclease activity
C0971_04270	COG4717	serine-type aminopeptidase activity
C0971_04275	COG3481	metal-dependent phosphohydrolase, HD sub domain
C0971_04285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0971_04305	COG1846	Transcriptional regulator
C0971_04335	COG0537	adenosine 5'-monophosphoramidase activity
C0971_04340	COG1131	(ABC) transporter
C0971_04345	COG4473	ABC transporter
C0971_04355	COG1473	amidohydrolase
C0971_04365	COG2329	Antibiotic biosynthesis monooxygenase
C0971_04400	COG1346	cytolysis
C0971_04405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C0971_04410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C0971_04415	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C0971_04420	COG1309	transcriptional regulator
C0971_04425	COG1511	domain protein
C0971_04435	COG1234	tRNA 3'-trailer cleavage
C0971_04455	COG1024	Enoyl-CoA hydratase
C0971_04470	COG1122	ATPase activity
C0971_04475	COG1396	sequence-specific DNA binding
C0971_04480	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C0971_04490	COG0501	Belongs to the peptidase M48B family
C0971_04505	COG5582	Belongs to the UPF0302 family
C0971_04510	COG4903	ComK protein
C0971_04530	COG0398	Pfam SNARE associated Golgi protein
C0971_04540	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C0971_04580	COG2311	Membrane
C0971_04585	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0971_04595	COG4585	Histidine kinase
C0971_04600	COG2197	response regulator
C0971_04605	COG1131	(ABC) transporter
C0971_04625	COG0367	asparagine synthase
C0971_04635	COG0366	Alpha amylase catalytic
C0971_04635	COG1874	Beta-galactosidase
C0971_04645	COG1666	GTP binding
C0971_04650	COG2996	Protein conserved in bacteria
C0971_04660	COG1307	EDD domain protein, DegV family
C0971_04665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C0971_04680	COG0561	phosphatase activity
C0971_04685	COG1073	alpha beta
C0971_04690	COG2151	metal-sulfur cluster biosynthetic enzyme
C0971_04695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C0971_04700	COG0303	'Molybdopterin
C0971_04705	COG1763	Mo-molybdopterin cofactor biosynthetic process
C0971_04710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C0971_04715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C0971_04720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0971_04730	COG0505	Belongs to the CarA family
C0971_04740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C0971_04750	COG0542	response to heat
C0971_04760	COG2267	carboxylic ester hydrolase activity
C0971_04770	COG1744	ABC transporter substrate-binding protein PnrA-like
C0971_04780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0971_04785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0971_04790	COG5504	Zn-dependent protease
C0971_04815	COG0180	Tryptophanyl-tRNA synthetase
C0971_04820	COG4166	transmembrane transport
C0971_04825	COG0601	transmembrane transport
C0971_04830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0971_04835	COG0444	Belongs to the ABC transporter superfamily
C0971_04840	COG4608	Belongs to the ABC transporter superfamily
C0971_04850	COG1393	Belongs to the ArsC family
C0971_04855	COG4862	establishment of competence for transformation
C0971_04860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0971_04870	COG1164	Oligoendopeptidase f
C0971_04875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0971_04880	COG2346	COG2346, Truncated hemoglobins
C0971_04885	COG0741	lytic transglycosylase activity
C0971_04890	COG4116	CYTH
C0971_04900	COG2357	RelA SpoT domain protein
C0971_04910	COG0564	pseudouridine synthase activity
C0971_04915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C0971_04920	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C0971_04950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0971_04975	COG2153	protein acetylation
C0971_04980	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C0971_04985	COG0765	amino acid transport
C0971_04990	COG0765	amino acid transport
C0971_04995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0971_05000	COG1126	abc transporter atp-binding protein
C0971_05035	COG0701	Predicted permease
C0971_05040	COG0803	Belongs to the bacterial solute-binding protein 9 family
C0971_05120	COG2197	response regulator
C0971_05125	COG4585	Histidine kinase
C0971_05130	COG1131	(ABC) transporter
C0971_05140	COG0842	Transport permease protein
C0971_05145	COG0693	protein deglycase activity
C0971_05150	COG1846	Transcriptional regulator
C0971_05155	COG4377	Putative membrane peptidase family (DUF2324)
C0971_05160	COG0626	cystathionine gamma-synthase activity
C0971_05165	COG2733	membrane
C0971_05170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C0971_05175	COG2376	Dihydroxyacetone kinase
C0971_05185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0971_05185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_05185	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C0971_05195	COG0753	catalase activity
C0971_05200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0971_05205	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C0971_05210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0971_05215	COG0438	transferase activity, transferring glycosyl groups
C0971_05230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0971_05235	COG0438	transferase activity, transferring glycosyl groups
C0971_05240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0971_05245	COG4242	Belongs to the peptidase S51 family
C0971_05250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C0971_05250	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0971_05270	COG3773	Cell wall hydrolase
C0971_05280	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C0971_05295	COG1191	sigma factor activity
C0971_05320	COG3594	Acyltransferase
C0971_05325	COG0840	transmembrane signaling receptor activity
C0971_05330	COG5002	protein histidine kinase activity
C0971_05335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0971_05340	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C0971_05345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0971_05350	COG0436	Aminotransferase
C0971_05355	COG1850	ribulose-bisphosphate carboxylase activity
C0971_05360	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
C0971_05365	COG0235	Class ii aldolase
C0971_05370	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C0971_05380	COG2223	nitrite transmembrane transporter activity
C0971_05385	COG3852	Histidine kinase
C0971_05390	COG1846	Transcriptional regulator
C0971_05400	COG0542	response to heat
C0971_05405	COG3949	Membrane
C0971_05420	COG4873	Protein conserved in bacteria
C0971_05440	COG1028	Short-chain dehydrogenase reductase Sdr
C0971_05450	COG2084	Dehydrogenase
C0971_05455	COG0436	Aminotransferase
C0971_05475	COG0835	chemotaxis
C0971_05475	COG0784	Response regulator, receiver
C0971_05485	COG5001	Diguanylate cyclase
C0971_05485	COG3300	MHYT domain
C0971_05490	COG1408	metallophosphoesterase
C0971_05495	COG4990	cell redox homeostasis
C0971_05500	COG2200	EAL domain
C0971_05520	COG4703	Protein of unknown function (DUF1797)
C0971_05525	COG0517	IMP dehydrogenase activity
C0971_05530	COG0477	Major facilitator Superfamily
C0971_05535	COG0583	DNA-binding transcription factor activity
C0971_05540	COG2171	N-acyltransferase activity
C0971_05545	COG1473	amidohydrolase
C0971_05550	COG0450	alkyl hydroperoxide reductase
C0971_05555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0971_05565	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C0971_05570	COG5503	Protein of unknown function (DUF1447)
C0971_05590	COG0022	dehydrogenase e1 component
C0971_05595	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0971_05625	COG1982	Orn Lys Arg decarboxylase major
C0971_05635	COG4476	Belongs to the UPF0223 family
C0971_05645	COG0483	inositol monophosphate 1-phosphatase activity
C0971_05650	COG1914	H( )-stimulated, divalent metal cation uptake system
C0971_05660	COG1217	gtp-binding protein TYPA
C0971_05675	COG4896	Protein conserved in bacteria
C0971_05690	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C0971_05695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C0971_05700	COG4838	Belongs to the UPF0358 family
C0971_05705	COG0772	Belongs to the SEDS family
C0971_05710	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C0971_05715	COG1612	heme a metabolic process
C0971_05745	COG3336	cytochrome c oxidase
C0971_05755	COG0628	permease
C0971_05765	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C0971_05770	COG2340	Cysteine-rich secretory protein family
C0971_05795	COG3679	Belongs to the UPF0342 family
C0971_05800	COG4471	UPF0298 protein
C0971_05815	COG0742	ribosomal rna small subunit methyltransferase
C0971_05820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C0971_05825	COG3314	Sporulation integral membrane protein YlbJ
C0971_05830	COG1752	Esterase of the alpha-beta hydrolase superfamily
C0971_05835	COG3480	Lon protease (S16) C-terminal proteolytic domain
C0971_05840	COG1323	Belongs to the UPF0348 family
C0971_05845	COG1399	metal-binding, possibly nucleic acid-binding protein
C0971_05850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C0971_05855	COG1024	Enoyl-CoA hydratase
C0971_05865	COG0439	Biotin carboxylase
C0971_05870	COG0511	ligase activity, forming carbon-carbon bonds
C0971_05875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0971_05880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C0971_05890	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C0971_05895	COG2001	Belongs to the MraZ family
C0971_05905	COG4839	cell division protein FtsL
C0971_05910	COG0768	penicillin binding
C0971_05915	COG0768	penicillin binding
C0971_05930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0971_05935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0971_05940	COG0772	Belongs to the SEDS family
C0971_05945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0971_05950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C0971_05955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C0971_05960	COG3879	Bacterial protein of unknown function (DUF881)
C0971_05965	COG3879	Bacterial protein of unknown function (DUF881)
C0971_05970	COG3856	small basic protein
C0971_05975	COG0849	cell division
C0971_05980	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C0971_05990	COG1191	sigma factor activity
C0971_05995	COG1191	sigma factor activity
C0971_06000	COG1873	PFAM PRC-barrel domain
C0971_06005	COG1496	oxidoreductase activity
C0971_06010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C0971_06015	COG1799	cell septum assembly
C0971_06020	COG0762	integral membrane protein
C0971_06025	COG2302	S4 RNA-binding domain
C0971_06030	COG3599	regulation of cell shape
C0971_06035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0971_06040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0971_06045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0971_06050	COG0564	pseudouridine synthase activity
C0971_06055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C0971_06065	COG0540	Belongs to the ATCase OTCase family
C0971_06070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0971_06080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0971_06085	COG0543	2 iron, 2 sulfur cluster binding
C0971_06090	COG0167	dihydroorotate dehydrogenase activity
C0971_06110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C0971_06115	COG1561	YicC-like family, N-terminal region
C0971_06125	COG0194	GDP metabolic process
C0971_06130	COG1758	RNA polymerase activity
C0971_06135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C0971_06140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C0971_06150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0971_06155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0971_06155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0971_06160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0971_06165	COG0631	protein serine/threonine phosphatase activity
C0971_06170	COG0515	serine threonine protein kinase
C0971_06170	COG2815	serine threonine protein kinase
C0971_06180	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0971_06185	COG1564	THIamine pyrophosphokinase
C0971_06200	COG1302	Protein conserved in bacteria
C0971_06205	COG1461	Dihydroxyacetone kinase
C0971_06210	COG1760	l-serine dehydratase
C0971_06215	COG1760	l-serine dehydratase
C0971_06220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0971_06225	COG1349	DNA-binding transcription factor activity
C0971_06230	COG0416	fatty acid biosynthetic process
C0971_06235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C0971_06240	COG1028	Short-chain dehydrogenase reductase Sdr
C0971_06245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0971_06255	COG1196	nuclear chromosome segregation
C0971_06260	COG0552	protein localization to endoplasmic reticulum
C0971_06270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C0971_06275	COG0228	four-way junction DNA binding
C0971_06280	COG1837	Belongs to the UPF0109 family
C0971_06290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0971_06295	COG0336	Belongs to the RNA methyltransferase TrmD family
C0971_06300	COG0335	large ribosomal subunit rRNA binding
C0971_06310	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C0971_06315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0971_06330	COG0045	succinate-CoA ligase (ADP-forming) activity
C0971_06335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0971_06340	COG0758	DNA mediated transformation
C0971_06345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0971_06350	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C0971_06355	COG4974	Belongs to the 'phage' integrase family
C0971_06360	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C0971_06365	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C0971_06370	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C0971_06375	COG1815	bacterial-type flagellum-dependent cell motility
C0971_06380	COG1558	bacterial-type flagellum-dependent cell motility
C0971_06385	COG1677	Flagellar hook-basal body complex protein FliE
C0971_06390	COG1766	The M ring may be actively involved in energy transduction
C0971_06395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0971_06400	COG1317	bacterial-type flagellum organization
C0971_06405	COG1157	protein secretion by the type III secretion system
C0971_06410	COG2882	bacterial-type flagellum organization
C0971_06425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C0971_06430	COG4786	Flagellar basal body rod
C0971_06435	COG1582	Flagellar protein (FlbD)
C0971_06440	COG1580	Controls the rotational direction of flagella during chemotaxis
C0971_06445	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0971_06450	COG1776	CheC inhibitor of MCP methylation
C0971_06450	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0971_06455	COG2201	protein-glutamate methylesterase activity
C0971_06460	COG3190	flagellar
C0971_06465	COG1338	Plays a role in the flagellum-specific transport system
C0971_06470	COG1987	bacterial-type flagellum assembly
C0971_06475	COG1684	flagellar biosynthetic protein fliR
C0971_06480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C0971_06485	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C0971_06490	COG1419	protein localization to endoplasmic reticulum
C0971_06495	COG0455	bacterial-type flagellum organization
C0971_06500	COG2201	protein-glutamate methylesterase activity
C0971_06505	COG0643	Histidine kinase
C0971_06505	COG2198	Histidine kinase
C0971_06510	COG0835	chemotaxis
C0971_06515	COG1776	CheC inhibitor of MCP methylation
C0971_06525	COG1191	sigma factor activity
C0971_06535	COG0052	Belongs to the universal ribosomal protein uS2 family
C0971_06540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C0971_06545	COG0528	UMP kinase activity
C0971_06550	COG0233	cytoplasmic translational termination
C0971_06555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0971_06560	COG4589	Belongs to the CDS family
C0971_06565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C0971_06570	COG0750	zinc metalloprotease
C0971_06580	COG2176	DNA-directed DNA polymerase activity
C0971_06585	COG0779	Required for maturation of 30S ribosomal subunits
C0971_06590	COG0195	Participates in both transcription termination and antitermination
C0971_06595	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C0971_06600	COG1358	cellular component organization or biogenesis
C0971_06610	COG1550	Protein conserved in bacteria
C0971_06615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0971_06620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0971_06625	COG0196	riboflavin kinase activity
C0971_06630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0971_06635	COG1185	polyribonucleotide nucleotidyltransferase activity
C0971_06640	COG0726	polysaccharide deacetylase
C0971_06650	COG1873	PFAM PRC-barrel domain
C0971_06655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0971_06660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C0971_06665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C0971_06670	COG0527	aspartate kinase activity
C0971_06675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0971_06680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C0971_06685	COG0740	serine-type endopeptidase activity
C0971_06695	COG1674	ftsk spoiiie
C0971_06695	COG4980	gas vesicle protein
C0971_06700	COG2188	Transcriptional regulator
C0971_06705	COG1744	ABC transporter substrate-binding protein PnrA-like
C0971_06710	COG3845	ABC transporter
C0971_06715	COG4603	Belongs to the binding-protein-dependent transport system permease family
C0971_06720	COG1079	Belongs to the binding-protein-dependent transport system permease family
C0971_06725	COG0612	Peptidase, M16
C0971_06730	COG0612	Peptidase, M16
C0971_06735	COG0300	oxidoreductase activity
C0971_06750	COG1426	Protein conserved in bacteria
C0971_06755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0971_06760	COG1058	Belongs to the CinA family
C0971_06760	COG1546	Belongs to the CinA family
C0971_06770	COG1418	mRNA catabolic process
C0971_06775	COG1692	metallophosphoesterase
C0971_06780	COG2359	stage V sporulation protein S
C0971_06785	COG0674	pyruvate-flavodoxin oxidoreductase activity
C0971_06785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C0971_06790	COG1013	pyruvate-flavodoxin oxidoreductase activity
C0971_06795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0971_06800	COG4550	Control of competence regulator ComK, YlbF/YmcA
C0971_06810	COG0346	lactoylglutathione lyase activity
C0971_06815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C0971_06820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C0971_06825	COG1077	Cell shape determining protein MreB Mrl
C0971_06830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C0971_06835	COG1923	regulation of RNA biosynthetic process
C0971_06840	COG0464	growth
C0971_06845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0971_06850	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C0971_06855	COG0789	Transcriptional regulator
C0971_06860	COG0174	glutamine synthetase
C0971_06880	COG2124	cytochrome p450
C0971_06895	COG1611	Belongs to the LOG family
C0971_06905	COG1247	-acetyltransferase
C0971_06950	COG2323	membrane
C0971_06955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C0971_06955	COG4451	ribulose bisphosphate carboxylase, small
C0971_06980	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C0971_06985	COG2323	membrane
C0971_06995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C0971_07005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C0971_07010	COG4224	UPF0291 protein
C0971_07025	COG3763	UPF0154 protein
C0971_07040	COG1132	(ABC) transporter
C0971_07045	COG1132	(ABC) transporter
C0971_07055	COG0785	Cytochrome C biogenesis protein
C0971_07060	COG2201	protein-glutamate methylesterase activity
C0971_07065	COG4846	Membrane protein involved in cytochrome C biogenesis
C0971_07090	COG0420	3'-5' exonuclease activity
C0971_07095	COG0419	ATPase involved in DNA repair
C0971_07110	COG5146	pantothenate kinase activity
C0971_07120	COG0702	epimerase
C0971_07125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0971_07130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C0971_07135	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C0971_07140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C0971_07170	COG3344	reverse transcriptase
C0971_07175	COG0604	alcohol dehydrogenase
C0971_07205	COG1247	-acetyltransferase
C0971_07215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0971_07220	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0971_07230	COG0791	NLP P60 protein
C0971_07230	COG1388	LysM domain
C0971_07245	COG1088	dTDP-glucose 4,6-dehydratase activity
C0971_07255	COG1086	Polysaccharide biosynthesis protein
C0971_07260	COG1216	Glycosyl transferase, family 2
C0971_07260	COG0463	Glycosyl transferase, family 2
C0971_07305	COG0438	transferase activity, transferring glycosyl groups
C0971_07380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0971_07390	COG2223	nitrite transmembrane transporter activity
C0971_07395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0971_07400	COG0243	molybdopterin cofactor binding
C0971_07405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0971_07410	COG2146	nitrite reductase [NAD(P)H] activity
C0971_07435	COG0156	8-amino-7-oxononanoate synthase activity
C0971_07440	COG2267	carboxylic ester hydrolase activity
C0971_07510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C0971_07540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0971_07580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C0971_07585	COG1116	anion transmembrane transporter activity
C0971_07590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_07595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0971_07625	COG1294	oxidase, subunit
C0971_07640	COG3118	belongs to the thioredoxin family
C0971_07645	COG0730	response to heat
C0971_07655	COG0425	Belongs to the sulfur carrier protein TusA family
C0971_07655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0971_07660	COG2210	Belongs to the sulfur carrier protein TusA family
C0971_07665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0971_07665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0971_07670	COG0425	Belongs to the sulfur carrier protein TusA family
C0971_07675	COG2210	Belongs to the sulfur carrier protein TusA family
C0971_07680	COG1937	Protein conserved in bacteria
C0971_07685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0971_07715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0971_07720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0971_07725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0971_07735	COG2267	carboxylic ester hydrolase activity
C0971_07760	COG0529	Catalyzes the synthesis of activated sulfate
C0971_07775	COG1605	Chorismate mutase
C0971_07775	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C0971_07805	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C0971_07810	COG2267	carboxylic ester hydrolase activity
C0971_07885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_07890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_07895	COG3414	Phosphotransferase system galactitol-specific IIB component
C0971_07900	COG3775	system Galactitol-specific IIC component
C0971_07905	COG1063	alcohol dehydrogenase
C0971_07915	COG1063	alcohol dehydrogenase
C0971_07920	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C0971_07925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0971_07950	COG0824	Thioesterase
C0971_07960	COG4841	protein insertion into membrane
C0971_07990	COG1136	(ABC) transporter
C0971_07995	COG0577	efflux transmembrane transporter activity
C0971_07995	COG1136	(ABC) transporter
C0971_08000	COG0745	RESPONSE REGULATOR receiver
C0971_08005	COG5002	protein histidine kinase activity
C0971_08030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0971_08030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C0971_08035	COG3973	AAA domain
C0971_08040	COG0477	Major facilitator Superfamily
C0971_08045	COG5002	protein histidine kinase activity
C0971_08050	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C0971_08070	COG1832	CoA-binding protein
C0971_08075	COG0187	DNA topoisomerase II activity
C0971_08080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C0971_08130	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C0971_08135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0971_08160	COG0456	acetyltransferase
C0971_08165	COG0697	spore germination
C0971_08175	COG1819	glycosyl
C0971_08210	COG0789	Transcriptional regulator
C0971_08215	COG2814	Major facilitator Superfamily
C0971_08230	COG0477	Major facilitator Superfamily
C0971_08235	COG0584	glycerophosphoryl diester phosphodiesterase
C0971_08245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0971_08250	COG1116	anion transmembrane transporter activity
C0971_08255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_08260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0971_08265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0971_08285	COG1960	acyl-CoA dehydrogenase activity
C0971_08300	COG2197	response regulator
C0971_08305	COG4585	Histidine kinase
C0971_08310	COG3239	Fatty acid desaturase
C0971_08320	COG1028	Short-chain dehydrogenase reductase Sdr
C0971_08325	COG0483	inositol monophosphate 1-phosphatase activity
C0971_08330	COG1757	Na H antiporter
C0971_08335	COG0693	protein deglycase activity
C0971_08360	COG0531	amino acid
C0971_08370	COG3663	DNA glycosylase
C0971_08375	COG0477	Major facilitator Superfamily
C0971_08380	COG1846	Transcriptional regulator
C0971_08385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0971_08395	COG0531	amino acid
C0971_08400	COG0531	amino acid
C0971_08405	COG5577	PFAM Coat F domain
C0971_08415	COG3647	Membrane
C0971_08425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0971_08435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C0971_08455	COG1119	ATPase activity
C0971_08465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0971_08470	COG2720	vancomycin resistance protein
C0971_08480	COG1418	mRNA catabolic process
C0971_08490	COG1664	Polymer-forming cytoskeletal
C0971_08495	COG1664	Polymer-forming cytoskeletal
C0971_08500	COG0789	Transcriptional regulator
C0971_08505	COG1714	RDD family
C0971_08515	COG1388	LysM domain
C0971_08515	COG3584	3D domain protein
C0971_08545	COG2814	Major facilitator Superfamily
C0971_08550	COG0303	'Molybdopterin
C0971_08555	COG2068	MobA-Related Protein
C0971_08560	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C0971_08585	COG3608	succinylglutamate desuccinylase aspartoacylase
C0971_08585	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C0971_08605	COG1346	cytolysis
C0971_08610	COG1380	Effector of murein hydrolase LrgA
C0971_08615	COG1012	belongs to the aldehyde dehydrogenase family
C0971_08625	COG0488	(ABC) transporter
C0971_08640	COG4149	molybdate abc transporter
C0971_08650	COG0697	spore germination
C0971_08665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C0971_08670	COG1268	BioY protein
C0971_08685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0971_08690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0971_08700	COG1253	flavin adenine dinucleotide binding
C0971_08740	COG0318	PFAM AMP-dependent synthetase and ligase
C0971_08745	COG0432	Pfam Uncharacterised protein family UPF0047
C0971_08760	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0971_08765	COG0567	Dehydrogenase, E1 component
C0971_08775	COG1960	acyl-CoA dehydrogenase activity
C0971_08790	COG2323	membrane
C0971_08800	COG1309	transcriptional regulator
C0971_08805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0971_08825	COG0681	Belongs to the peptidase S26 family
C0971_08835	COG4637	Psort location Cytoplasmic, score
C0971_08840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0971_08845	COG2169	Transcriptional regulator
C0971_08855	COG0456	acetyltransferase
C0971_08870	COG1525	nuclease
C0971_08895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_08910	COG0626	cystathionine gamma-synthase activity
C0971_08915	COG0626	cystathionine gamma-synthase activity
C0971_08920	COG0646	methionine synthase
C0971_08920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C0971_08925	COG0646	methionine synthase
C0971_08925	COG1410	methionine synthase
C0971_08930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0971_08935	COG1607	acyl-coa hydrolase
C0971_08945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C0971_08950	COG2267	carboxylic ester hydrolase activity
C0971_08960	COG0768	penicillin binding
C0971_08975	COG1131	(ABC) transporter
C0971_08980	COG1725	Transcriptional regulator
C0971_08985	COG0697	spore germination
C0971_08995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0971_09010	COG0586	Pfam SNARE associated Golgi protein
C0971_09025	COG3383	formate dehydrogenase (NAD+) activity
C0971_09030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C0971_09035	COG1464	Belongs to the NlpA lipoprotein family
C0971_09040	COG2011	ABC-type metal ion transport system permease component
C0971_09045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0971_09050	COG0778	Nitroreductase
C0971_09055	COG0535	radical SAM domain protein
C0971_09060	COG0725	ABC transporter, periplasmic molybdate-binding protein
C0971_09070	COG0494	nUDIX hydrolase
C0971_09095	COG1842	Phage shock protein A
C0971_09105	COG4608	Belongs to the ABC transporter superfamily
C0971_09110	COG0791	NLP P60 protein
C0971_09115	COG4948	Mandelate Racemase Muconate Lactonizing
C0971_09120	COG1619	proteins homologs of microcin C7 resistance protein MccF
C0971_09125	COG4166	transmembrane transport
C0971_09130	COG0444	Belongs to the ABC transporter superfamily
C0971_09135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0971_09140	COG0601	transmembrane transport
C0971_09145	COG2362	D-Aminopeptidase
C0971_09150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C0971_09155	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C0971_09165	COG0527	aspartate kinase activity
C0971_09180	COG2861	carbohydrate metabolic process
C0971_09195	COG1176	ABC-type spermidine putrescine transport system, permease component I
C0971_09220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0971_09225	COG0672	)-iron permease
C0971_09230	COG2837	iron assimilation
C0971_09235	COG2822	iron ion transport
C0971_09240	COG0778	Nitroreductase
C0971_09245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0971_09250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0971_09260	COG0561	phosphatase activity
C0971_09265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0971_09265	COG0140	phosphoribosyl-ATP diphosphatase activity
C0971_09270	COG0284	orotidine-5'-phosphate decarboxylase activity
C0971_09280	COG4948	Mandelate Racemase Muconate Lactonizing
C0971_09290	COG1473	amidohydrolase
C0971_09300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C0971_09325	COG1657	PFAM Prenyltransferase squalene oxidase
C0971_09330	COG3300	MHYT domain
C0971_09330	COG5001	Diguanylate cyclase
C0971_09340	COG0431	NADPH-dependent FMN reductase
C0971_09345	COG5583	Uncharacterized small protein (DUF2292)
C0971_09370	COG0840	transmembrane signaling receptor activity
C0971_09380	COG0720	synthase
C0971_09390	COG0243	molybdopterin cofactor binding
C0971_09400	COG2132	Multicopper oxidase
C0971_09405	COG0133	tryptophan synthase activity
C0971_09410	COG3883	PFAM NLP P60 protein
C0971_09410	COG0791	NLP P60 protein
C0971_09425	COG1061	Type III restriction enzyme res subunit
C0971_09460	COG0494	nUDIX hydrolase
C0971_09475	COG2766	serine protein kinase
C0971_09480	COG2718	Belongs to the UPF0229 family
C0971_09485	COG2719	SpoVR family
C0971_09520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0971_09535	COG0531	amino acid
C0971_09540	COG1113	amino acid transport
C0971_09565	COG5646	InterPro IPR014922
C0971_09570	COG5646	InterPro IPR014922
C0971_09580	COG0475	glutathione-regulated potassium exporter activity
C0971_09595	COG0672	)-iron permease
C0971_09600	COG2217	Heavy metal translocating P-type atpase
C0971_09605	COG2608	mercury ion transmembrane transporter activity
C0971_09620	COG0004	ammonium transporteR
C0971_09630	COG1742	UPF0060 membrane protein
C0971_09635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0971_09640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0971_09645	COG0716	FMN binding
C0971_09655	COG2318	DinB family
C0971_09685	COG0475	glutathione-regulated potassium exporter activity
C0971_09700	COG0456	acetyltransferase
C0971_09700	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C0971_09725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0971_09750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_09755	COG2002	toxin-antitoxin pair type II binding
C0971_09765	COG0477	Major facilitator Superfamily
C0971_09770	COG0673	inositol 2-dehydrogenase activity
C0971_09780	COG0561	phosphatase activity
C0971_09785	COG0084	hydrolase, TatD family'
C0971_09795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_09805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0971_09810	COG1131	(ABC) transporter
C0971_09815	COG0842	Transport permease protein
C0971_09820	COG4585	Histidine kinase
C0971_09825	COG2197	response regulator
C0971_09845	COG1929	Belongs to the glycerate kinase type-1 family
C0971_09850	COG2080	2 iron, 2 sulfur cluster binding
C0971_09860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C0971_09870	COG1408	metallophosphoesterase
C0971_09875	COG0726	polysaccharide deacetylase
C0971_09915	COG2203	Gaf domain
C0971_09915	COG2199	diguanylate cyclase activity
C0971_09915	COG2200	EAL domain
C0971_09995	COG0791	NLP P60 protein
C0971_09995	COG1388	LysM domain
C0971_10000	COG3953	SLT domain
C0971_10000	COG5280	Phage tail tape measure protein TP901
C0971_10080	COG5484	DNA packaging
C0971_10115	COG2201	protein-glutamate methylesterase activity
C0971_10120	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C0971_10130	COG1484	DNA-dependent DNA replication
C0971_10140	COG3723	Recombinational DNA repair protein, rece pathway
C0971_10145	COG5377	YqaJ viral recombinase family
C0971_10190	COG1396	sequence-specific DNA binding
C0971_10220	COG0582	viral genome integration into host DNA
C0971_10250	COG0134	indole-3-glycerol-phosphate synthase activity
C0971_10255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0971_10260	COG0512	Glutamine amidotransferase of anthranilate synthase
C0971_10260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0971_10275	COG2814	Major facilitator Superfamily
C0971_10285	COG0596	Alpha beta hydrolase
C0971_10305	COG1131	(ABC) transporter
C0971_10310	COG1846	Transcriptional regulator
C0971_10315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0971_10315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0971_10315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_10320	COG1105	Belongs to the carbohydrate kinase PfkB family
C0971_10325	COG1349	DNA-binding transcription factor activity
C0971_10330	COG2259	Doxx family
C0971_10335	COG1959	2 iron, 2 sulfur cluster binding
C0971_10340	COG1331	Highly conserved protein containing a thioredoxin domain
C0971_10345	COG1331	Highly conserved protein containing a thioredoxin domain
C0971_10355	COG0456	acetyltransferase
C0971_10360	COG1279	arginine transmembrane transporter activity
C0971_10365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0971_10375	COG0805	protein transport
C0971_10430	COG2814	Major facilitator Superfamily
C0971_10440	COG0659	secondary active sulfate transmembrane transporter activity
C0971_10455	COG4191	Histidine kinase
C0971_10480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C0971_10485	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C0971_10515	COG0586	Pfam SNARE associated Golgi protein
C0971_10525	COG1376	ErfK ybiS ycfS ynhG family protein
C0971_10530	COG1793	dna ligase
C0971_10530	COG3285	dna ligase
C0971_10545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C0971_10550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0971_10550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0971_10555	COG0307	riboflavin synthase, alpha
C0971_10560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0971_10560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0971_10570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0971_10605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0971_10620	COG1028	Short-chain dehydrogenase reductase Sdr
C0971_10630	COG2340	Cysteine-rich secretory protein family
C0971_10685	COG5002	protein histidine kinase activity
C0971_10690	COG0745	RESPONSE REGULATOR receiver
C0971_10725	COG1316	TRANSCRIPTIONal
C0971_10730	COG3409	Peptidoglycan-binding domain 1 protein
C0971_10730	COG0793	Belongs to the peptidase S41A family
C0971_10735	COG1876	peptidase activity
C0971_10750	COG4326	sporulation control protein
C0971_10765	COG4479	Belongs to the UPF0346 family
C0971_10775	COG1509	lysine 2,3-aminomutase activity
C0971_10780	COG3829	transcription factor binding
C0971_10785	COG0456	acetyltransferase
C0971_10790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0971_10795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C0971_10800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C0971_10805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0971_10835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0971_10835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0971_10840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0971_10840	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C0971_10850	COG2755	lipolytic protein G-D-S-L family
C0971_10855	COG1999	signal sequence binding
C0971_10865	COG0805	protein transport
C0971_10870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0971_10875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0971_10880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C0971_10895	COG0861	Integral membrane protein TerC family
C0971_10905	COG2521	methyltransferase
C0971_10905	COG2136	Putative SAM-dependent methyltransferase
C0971_10915	COG0129	dihydroxy-acid dehydratase activity
C0971_10920	COG1413	lyase activity
C0971_10925	COG0488	(ABC) transporter
C0971_10930	COG1418	mRNA catabolic process
C0971_10935	COG1307	EDD domain protein, DegV family
C0971_10965	COG1321	iron dependent repressor
C0971_10975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0971_10980	COG0277	FAD linked oxidase domain protein
C0971_11010	COG0328	RNA-DNA hybrid ribonuclease activity
C0971_11030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0971_11035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C0971_11055	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C0971_11060	COG1755	Isoprenylcysteine carboxyl methyltransferase
C0971_11065	COG3424	synthase
C0971_11075	COG2233	PERMEase
C0971_11080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0971_11090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0971_11095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0971_11100	COG0697	spore germination
C0971_11105	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C0971_11110	COG1199	ATP-dependent helicase activity
C0971_11125	COG0116	Belongs to the methyltransferase superfamily
C0971_11130	COG3300	MHYT domain
C0971_11130	COG5001	Diguanylate cyclase
C0971_11150	COG3359	exonuclease
C0971_11155	COG1111	helicase
C0971_11155	COG1205	dead DEAH box helicase
C0971_11160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0971_11165	COG1151	hydroxylamine reductase activity
C0971_11200	COG3331	DNA recombination
C0971_11205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0971_11205	COG4499	WXG100 protein secretion system (Wss), protein YukC
C0971_11220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C0971_11225	COG3935	DnaD domain protein
C0971_11230	COG0017	Asparaginyl-tRNA synthetase
C0971_11235	COG0436	Aminotransferase
C0971_11250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0971_11250	COG1199	ATP-dependent helicase activity
C0971_11255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C0971_11260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C0971_11265	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C0971_11275	COG0617	tRNA 3'-terminal CCA addition
C0971_11280	COG0438	transferase activity, transferring glycosyl groups
C0971_11285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0971_11290	COG1803	Methylglyoxal synthase
C0971_11295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C0971_11300	COG1694	Mazg nucleotide pyrophosphohydrolase
C0971_11305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C0971_11310	COG2738	Putative neutral zinc metallopeptidase
C0971_11320	COG4347	Protein of unknown function (DUF1405)
C0971_11345	COG5582	Belongs to the UPF0302 family
C0971_11350	COG0457	Tetratricopeptide repeat
C0971_11360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0971_11365	COG0287	Prephenate dehydrogenase
C0971_11370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0971_11380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0971_11385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0971_11390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C0971_11395	COG0105	UTP biosynthetic process
C0971_11400	COG0142	geranyltranstransferase activity
C0971_11405	COG2226	methyltransferase
C0971_11410	COG0142	geranyltranstransferase activity
C0971_11420	COG0302	gtp cyclohydrolase
C0971_11425	COG0776	regulation of translation
C0971_11435	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C0971_11455	COG1160	GTP binding
C0971_11480	COG1304	FMN binding
C0971_11485	COG0539	negative regulation of cytoplasmic translation
C0971_11495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C0971_11510	COG2959	enzyme of heme biosynthesis
C0971_11515	COG3773	Cell wall hydrolase
C0971_11515	COG3409	Peptidoglycan-binding domain 1 protein
C0971_11520	COG2339	peptidase activity
C0971_11530	COG0492	ferredoxin-NADP+ reductase activity
C0971_11535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C0971_11540	COG4862	establishment of competence for transformation
C0971_11545	COG1408	metallophosphoesterase
C0971_11555	COG1388	LysM domain
C0971_11560	COG1266	CAAX protease self-immunity
C0971_11565	COG0514	ATP-dependent DNA helicase (RecQ)
C0971_11580	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C0971_11585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0971_11590	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C0971_11595	COG0739	heme binding
C0971_11605	COG1595	DNA-templated transcription, initiation
C0971_11615	COG5002	protein histidine kinase activity
C0971_11620	COG0745	RESPONSE REGULATOR receiver
C0971_11625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0971_11630	COG1333	cytochrome c biogenesis protein
C0971_11640	COG1187	pseudouridine synthase activity
C0971_11645	COG0700	Nucleoside recognition
C0971_11650	COG2715	membrane protein required for spore maturation
C0971_11655	COG1686	Belongs to the peptidase S11 family
C0971_11660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C0971_11670	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C0971_11675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C0971_11685	COG1547	Domain of unknown function (DUF309)
C0971_11700	COG0697	spore germination
C0971_11720	COG2172	sigma factor antagonist activity
C0971_11730	COG1686	Belongs to the peptidase S11 family
C0971_11750	COG4974	Belongs to the 'phage' integrase family
C0971_11760	COG0735	belongs to the Fur family
C0971_11765	COG1300	Membrane
C0971_11770	COG1379	DNA repair
C0971_11780	COG0667	Aldo Keto reductase
C0971_11795	COG1959	2 iron, 2 sulfur cluster binding
C0971_11800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C0971_11805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C0971_11815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0971_11820	COG1073	alpha beta
C0971_11825	COG1294	oxidase, subunit
C0971_11830	COG1271	oxidase subunit
C0971_11835	COG4918	Iron-sulphur cluster biosynthesis
C0971_11845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0971_11855	COG0300	oxidoreductase activity
C0971_11860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0971_11865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0971_11870	COG1902	pentaerythritol trinitrate reductase activity
C0971_11875	COG1234	tRNA 3'-trailer cleavage
C0971_11880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C0971_11885	COG4086	secreted protein
C0971_11890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C0971_11895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0971_11900	COG0835	chemotaxis
C0971_11905	COG2195	Cleaves the N-terminal amino acid of tripeptides
C0971_11910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0971_11915	COG0346	lactoylglutathione lyase activity
C0971_11920	COG1126	abc transporter atp-binding protein
C0971_11925	COG0765	amino acid transport
C0971_11930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0971_11950	COG1703	isobutyryl-CoA mutase activity
C0971_11955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0971_11955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0971_11965	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0971_11970	COG0022	dehydrogenase e1 component
C0971_11975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C0971_11980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0971_11985	COG3426	butyrate kinase activity
C0971_11995	COG0280	phosphate acetyltransferase
C0971_12000	COG3829	transcription factor binding
C0971_12000	COG3290	protein histidine kinase activity
C0971_12010	COG0584	glycerophosphoryl diester phosphodiesterase
C0971_12080	COG0750	zinc metalloprotease
C0971_12085	COG0497	DNA recombination
C0971_12090	COG1438	arginine binding
C0971_12095	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C0971_12100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0971_12110	COG1722	exodeoxyribonuclease VII activity
C0971_12115	COG1570	exodeoxyribonuclease VII activity
C0971_12120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0971_12125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0971_12130	COG1302	Protein conserved in bacteria
C0971_12135	COG0439	Biotin carboxylase
C0971_12140	COG0511	ligase activity, forming carbon-carbon bonds
C0971_12180	COG3854	ATPases associated with a variety of cellular activities
C0971_12195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0971_12200	COG0006	proline dipeptidase activity
C0971_12205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C0971_12215	COG3872	metal-dependent enzyme
C0971_12225	COG1752	Esterase of the alpha-beta hydrolase superfamily
C0971_12230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0971_12250	COG0095	Lipoate-protein ligase
C0971_12255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0971_12270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0971_12275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C0971_12280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0971_12320	COG4537	Required for transformation and DNA binding
C0971_12325	COG1459	type II secretion system
C0971_12330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0971_12355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0971_12380	COG1368	sulfuric ester hydrolase activity
C0971_12385	COG1940	carbohydrate kinase activity
C0971_12400	COG0457	Tetratricopeptide repeat
C0971_12400	COG0705	Rhomboid family
C0971_12410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C0971_12415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0971_12445	COG0704	Plays a role in the regulation of phosphate uptake
C0971_12455	COG0768	penicillin binding
C0971_12460	COG0477	Major facilitator Superfamily
C0971_12475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C0971_12495	COG0248	Ppx GppA phosphatase
C0971_12505	COG2839	Protein conserved in bacteria
C0971_12510	COG5521	maltodextrose utilization protein MalA
C0971_12515	COG2814	Major facilitator Superfamily
C0971_12525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C0971_12530	COG4709	membrane
C0971_12535	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C0971_12540	COG0735	belongs to the Fur family
C0971_12545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0971_12550	COG1121	(ABC) transporter
C0971_12555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C0971_12565	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C0971_12570	COG0513	Belongs to the DEAD box helicase family
C0971_12580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C0971_12585	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C0971_12590	COG2384	SAM-dependent methyltransferase
C0971_12595	COG2010	Cytochrome c
C0971_12600	COG1960	acyl-CoA dehydrogenase activity
C0971_12605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0971_12610	COG0358	DNA primase activity
C0971_12615	COG1671	Belongs to the UPF0178 family
C0971_12620	COG0392	lysyltransferase activity
C0971_12620	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C0971_12625	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C0971_12630	COG0517	IMP dehydrogenase activity
C0971_12635	COG0423	glycine-tRNA ligase activity
C0971_12640	COG1381	Involved in DNA repair and RecF pathway recombination
C0971_12660	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C0971_12670	COG1480	7TM receptor with intracellular HD hydrolase
C0971_12675	COG1702	phosphate starvation-inducible protein PhoH
C0971_12695	COG4864	UPF0365 protein
C0971_12700	COG1030	water channel activity
C0971_12705	COG1610	YqeY-like protein
C0971_12715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C0971_12720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0971_12725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C0971_12730	COG2264	protein methyltransferase activity
C0971_12740	COG0443	Heat shock 70 kDa protein
C0971_12750	COG1420	regulation of RNA biosynthetic process
C0971_12755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0971_12760	COG0481	GTPase activity
C0971_12770	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0971_12780	COG0268	Binds directly to 16S ribosomal RNA
C0971_12785	COG1466	dna polymerase III delta subunit
C0971_12795	COG0658	competence protein
C0971_12795	COG2333	competence protein COMEC
C0971_12800	COG2131	deaminase
C0971_12805	COG1596	polysaccharide export
C0971_12805	COG1555	photosystem II stabilization
C0971_12810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0971_12815	COG2226	methyltransferase
C0971_12820	COG0799	negative regulation of ribosome biogenesis
C0971_12825	COG1713	HD superfamily hydrolase involved in NAD metabolism
C0971_12830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C0971_12835	COG1534	Rna-binding protein
C0971_12845	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C0971_12850	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C0971_12860	COG0688	phosphatidylethanolamine metabolic process
C0971_12880	COG0626	cystathionine gamma-synthase activity
C0971_12885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0971_12890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C0971_12895	COG2226	methyltransferase
C0971_12910	COG0768	penicillin binding
C0971_12920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0971_12925	COG0572	uridine kinase
C0971_12930	COG0826	peptidase U32
C0971_12935	COG0826	peptidase U32
C0971_12940	COG4122	O-methyltransferase activity
C0971_12945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0971_12950	COG3906	Belongs to the UPF0473 family
C0971_12960	COG4472	Bacterial protein of unknown function (DUF965)
C0971_12965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0971_12970	COG0628	permease
C0971_12985	COG3881	PFAM PRC-barrel domain
C0971_12990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0971_13000	COG0482	sulfurtransferase activity
C0971_13005	COG1104	cysteine desulfurase activity
C0971_13010	COG1959	2 iron, 2 sulfur cluster binding
C0971_13015	COG2364	Membrane
C0971_13020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C0971_13030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0971_13035	COG0124	histidyl-tRNA synthetase
C0971_13040	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0971_13040	COG3103	Sh3 type 3 domain protein
C0971_13040	COG4991	sh3 domain protein
C0971_13045	COG1490	D-aminoacyl-tRNA deacylase activity
C0971_13050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0971_13055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0971_13060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C0971_13060	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C0971_13065	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C0971_13070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0971_13070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0971_13080	COG2244	polysaccharide biosynthetic process
C0971_13085	COG2323	membrane
C0971_13095	COG1309	transcriptional regulator
C0971_13105	COG1862	Preprotein translocase
C0971_13115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C0971_13130	COG0632	four-way junction helicase activity
C0971_13140	COG0217	transcriptional regulatory protein
C0971_13160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0971_13165	COG0157	Belongs to the NadC ModD family
C0971_13170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C0971_13175	COG1104	cysteine desulfurase activity
C0971_13180	COG0077	Prephenate dehydratase
C0971_13185	COG4492	Belongs to the UPF0735 family
C0971_13190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0971_13195	COG3290	protein histidine kinase activity
C0971_13200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C0971_13205	COG2868	ribosomal protein
C0971_13210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C0971_13220	COG1994	Peptidase M50
C0971_13225	COG0739	heme binding
C0971_13230	COG2894	cell division
C0971_13235	COG0850	regulation of cytokinetic process
C0971_13245	COG1792	Involved in formation and maintenance of cell shape
C0971_13250	COG1077	Cell shape determining protein MreB Mrl
C0971_13255	COG2003	Belongs to the UPF0758 family
C0971_13290	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C0971_13310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0971_13335	COG0285	dihydrofolate synthase activity
C0971_13340	COG0525	valine-tRNA ligase activity
C0971_13350	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0971_13355	COG1388	LysM domain
C0971_13355	COG1388	LysM domain
C0971_13360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0971_13365	COG0113	porphobilinogen synthase activity
C0971_13370	COG1587	Uroporphyrinogen-III synthase
C0971_13375	COG0181	hydroxymethylbilane synthase activity
C0971_13380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0971_13395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C0971_13400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C0971_13405	COG0470	DNA polymerase III
C0971_13405	COG1067	ATP-dependent peptidase activity
C0971_13410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C0971_13415	COG0544	peptidyl-prolyl cis-trans isomerase activity
C0971_13420	COG0457	Tetratricopeptide repeat
C0971_13420	COG1477	protein flavinylation
C0971_13425	COG0066	3-isopropylmalate dehydratase activity
C0971_13430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0971_13435	COG0473	3-isopropylmalate dehydrogenase activity
C0971_13440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0971_13445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C0971_13450	COG0440	acetolactate synthase activity
C0971_13455	COG0028	Belongs to the TPP enzyme family
C0971_13460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0971_13475	COG0622	Phosphoesterase
C0971_13485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0971_13490	COG5401	PFAM Sporulation and spore germination
C0971_13505	COG1846	Transcriptional regulator
C0971_13510	COG2031	fatty acid transporter
C0971_13515	COG2197	response regulator
C0971_13520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0971_13525	COG1053	succinate dehydrogenase
C0971_13530	COG2009	succinate dehydrogenase
C0971_13535	COG1719	4-vinyl reductase, 4VR
C0971_13545	COG0322	excinuclease ABC activity
C0971_13550	COG3118	belongs to the thioredoxin family
C0971_13555	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C0971_13560	COG2086	electron transfer activity
C0971_13565	COG1024	Enoyl-CoA hydratase
C0971_13570	COG1309	transcriptional regulator
C0971_13575	COG0318	PFAM AMP-dependent synthetase and ligase
C0971_13580	COG3766	membrane
C0971_13585	COG1193	negative regulation of DNA recombination
C0971_13590	COG1796	DNA polymerase
C0971_13590	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C0971_13595	COG1286	toxin biosynthetic process
C0971_13600	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C0971_13605	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0971_13610	COG0072	phenylalanine-tRNA ligase activity
C0971_13610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0971_13615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0971_13620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0971_13630	COG1363	Peptidase, m42
C0971_13650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C0971_13655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C0971_13660	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C0971_13665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C0971_13675	COG1484	DNA-dependent DNA replication
C0971_13680	COG3611	Membrane attachment protein
C0971_13685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0971_13690	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C0971_13695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0971_13700	COG0237	dephospho-CoA kinase activity
C0971_13705	COG1971	Probably functions as a manganese efflux pump
C0971_13710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0971_13715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0971_13715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0971_13735	COG5002	protein histidine kinase activity
C0971_13740	COG0745	RESPONSE REGULATOR receiver
C0971_13745	COG0039	L-malate dehydrogenase activity
C0971_13750	COG0538	isocitrate dehydrogenase activity
C0971_13760	COG0372	Belongs to the citrate synthase family
C0971_13765	COG2707	UPF0756 membrane protein
C0971_13770	COG0628	permease
C0971_13775	COG3030	protein affecting phage T7 exclusion by the F plasmid
C0971_13790	COG0825	malonyl-CoA metabolic process
C0971_13795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C0971_13800	COG1725	Transcriptional regulator
C0971_13805	COG0281	malic enzyme
C0971_13810	COG0587	DNA-directed DNA polymerase activity
C0971_13825	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C0971_13835	COG4109	DRTGG domain
C0971_13845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C0971_13850	COG0006	proline dipeptidase activity
C0971_13870	COG0165	Argininosuccinate lyase
C0971_13875	COG0137	argininosuccinate synthase activity
C0971_13885	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0971_13895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C0971_13900	COG0827	DNA restriction-modification system
C0971_13905	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C0971_13910	COG3874	Sporulation protein YtfJ
C0971_13920	COG1714	RDD family
C0971_13925	COG0616	signal peptide processing
C0971_13930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0971_13935	COG2962	Rard protein
C0971_13940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0971_13950	COG0301	tRNA thio-modification
C0971_13955	COG1104	cysteine desulfurase activity
C0971_13960	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C0971_13965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C0971_13970	COG1309	transcriptional regulator
C0971_13975	COG1956	GAF domain-containing protein
C0971_13980	COG2199	diguanylate cyclase activity
C0971_13980	COG2203	Gaf domain
C0971_13985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0971_13990	COG1012	belongs to the aldehyde dehydrogenase family
C0971_14005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0971_14015	COG0454	-acetyltransferase
C0971_14020	COG0517	IMP dehydrogenase activity
C0971_14025	COG0123	including yeast histone deacetylase and acetoin utilization protein
C0971_14035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C0971_14035	COG1605	Chorismate mutase
C0971_14045	COG4980	gas vesicle protein
C0971_14055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0971_14060	COG1674	ftsk spoiiie
C0971_14060	COG1674	ftsk spoiiie
C0971_14070	COG4848	Belongs to the UPF0354 family
C0971_14075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0971_14080	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C0971_14085	COG1363	Peptidase, m42
C0971_14095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0971_14105	COG0510	thiamine kinase activity
C0971_14110	COG1523	belongs to the glycosyl hydrolase 13 family
C0971_14125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0971_14130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0971_14145	COG1131	(ABC) transporter
C0971_14155	COG1349	DNA-binding transcription factor activity
C0971_14160	COG1187	pseudouridine synthase activity
C0971_14170	COG2244	polysaccharide biosynthetic process
C0971_14175	COG2081	HI0933 family
C0971_14185	COG3162	membrane
C0971_14190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0971_14200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0971_14210	COG0495	leucyl-tRNA aminoacylation
C0971_14215	COG2814	Major facilitator Superfamily
C0971_14230	COG1242	4 iron, 4 sulfur cluster binding
C0971_14235	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C0971_14245	COG2267	carboxylic ester hydrolase activity
C0971_14250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C0971_14255	COG4990	cell redox homeostasis
C0971_14260	COG0367	asparagine synthase
C0971_14265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C0971_14285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0971_14290	COG1116	anion transmembrane transporter activity
C0971_14295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_14300	COG0494	nUDIX hydrolase
C0971_14315	COG1937	Protein conserved in bacteria
C0971_14330	COG0640	Transcriptional regulator
C0971_14345	COG3546	catalase activity
C0971_14350	COG1854	S-ribosylhomocysteine lyase activity
C0971_14355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C0971_14360	COG0288	reversible hydration of carbon dioxide
C0971_14370	COG0318	PFAM AMP-dependent synthetase and ligase
C0971_14375	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C0971_14380	COG0596	Alpha beta hydrolase
C0971_14385	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C0971_14390	COG1169	isochorismate synthase
C0971_14395	COG1575	Belongs to the MenA family. Type 1 subfamily
C0971_14400	COG0058	SHG alpha-glucan phosphorylase activity
C0971_14405	COG0297	glycogen (starch) synthase activity
C0971_14410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C0971_14415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C0971_14560	COG1285	pathogenesis
C0971_14570	COG1733	regulation of RNA biosynthetic process
C0971_14595	COG3832	glyoxalase III activity
C0971_14600	COG0640	Transcriptional regulator
C0971_14605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C0971_14640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0971_14680	COG0004	ammonium transporteR
C0971_14690	COG2076	Multidrug Resistance protein
C0971_14705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0971_14710	COG0671	phosphoesterase, PA-phosphatase related
C0971_14715	COG0586	Pfam SNARE associated Golgi protein
C0971_14725	COG3850	Histidine kinase
C0971_14725	COG5002	protein histidine kinase activity
C0971_14745	COG2124	cytochrome p450
C0971_14750	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C0971_14775	COG0791	NLP P60 protein
C0971_14775	COG3883	PFAM NLP P60 protein
C0971_14840	COG0456	acetyltransferase
C0971_14845	COG3153	acetyltransferase
C0971_14845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0971_14850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0971_14865	COG1979	alcohol dehydrogenase
C0971_14870	COG2155	Conserved Protein
C0971_14875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0971_14880	COG1098	S1 RNA binding domain
C0971_14885	COG0436	Aminotransferase
C0971_14890	COG1522	sequence-specific DNA binding
C0971_14895	COG2267	carboxylic ester hydrolase activity
C0971_14900	COG0861	Integral membrane protein TerC family
C0971_14905	COG2032	superoxide dismutase activity
C0971_14915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0971_14930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0971_14930	COG2111	Na H antiporter
C0971_14935	COG2050	protein possibly involved in aromatic compounds catabolism
C0971_14940	COG0586	Pfam SNARE associated Golgi protein
C0971_14955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0971_14965	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C0971_14975	COG3584	3D domain protein
C0971_14985	COG0494	nUDIX hydrolase
C0971_14990	COG1252	NADH dehydrogenase
C0971_15000	COG0316	Belongs to the HesB IscA family
C0971_15010	COG4844	belongs to the
C0971_15015	COG1252	NADH dehydrogenase
C0971_15030	COG4837	Protein of unknown function (DUF1462)
C0971_15035	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C0971_15045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0971_15050	COG0460	homoserine dehydrogenase
C0971_15055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0971_15060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C0971_15065	COG0647	UMP catabolic process
C0971_15070	COG2445	Protein of unknown function DUF86
C0971_15075	COG2199	diguanylate cyclase activity
C0971_15075	COG3287	FIST C domain
C0971_15075	COG2200	EAL domain
C0971_15090	COG4470	Protein conserved in bacteria
C0971_15100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C0971_15105	COG0739	heme binding
C0971_15145	COG0737	Belongs to the 5'-nucleotidase family
C0971_15150	COG1801	Protein of unknown function DUF72
C0971_15155	COG0719	Fe-S assembly protein
C0971_15160	COG0822	iron-sulfur transferase activity
C0971_15165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0971_15170	COG0719	Fe-S assembly protein
C0971_15175	COG0396	ATPase activity
C0971_15185	COG1464	Belongs to the NlpA lipoprotein family
C0971_15190	COG2011	ABC-type metal ion transport system permease component
C0971_15195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0971_15200	COG2873	o-acetylhomoserine
C0971_15205	COG3118	belongs to the thioredoxin family
C0971_15210	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C0971_15215	COG0509	glycine decarboxylation via glycine cleavage system
C0971_15220	COG1393	Belongs to the ArsC family
C0971_15225	COG1960	acyl-CoA dehydrogenase activity
C0971_15230	COG0183	Belongs to the thiolase family
C0971_15235	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0971_15235	COG1024	Enoyl-CoA hydratase
C0971_15255	COG3361	conserved protein (COG2071)
C0971_15265	COG1120	ATPase activity
C0971_15270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0971_15275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0971_15295	COG0772	Belongs to the SEDS family
C0971_15300	COG0656	L-ascorbic acid biosynthetic process
C0971_15310	COG3764	Sortase (surface protein transpeptidase)
C0971_15315	COG0702	epimerase
C0971_15335	COG0598	Magnesium transport protein CorA
C0971_15345	COG2172	sigma factor antagonist activity
C0971_15350	COG4191	Histidine kinase
C0971_15355	COG0789	Transcriptional regulator
C0971_15360	COG2514	catechol 2,3-dioxygenase activity
C0971_15365	COG1227	inorganic diphosphatase activity
C0971_15375	COG1959	2 iron, 2 sulfur cluster binding
C0971_15380	COG0482	sulfurtransferase activity
C0971_15390	COG2814	Major facilitator Superfamily
C0971_15395	COG0583	DNA-binding transcription factor activity
C0971_15400	COG1511	domain protein
C0971_15405	COG0531	amino acid
C0971_15430	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C0971_15435	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C0971_15445	COG2205	protein histidine kinase activity
C0971_15455	COG0210	DNA helicase
C0971_15555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C0971_15560	COG0557	exoribonuclease II activity
C0971_15565	COG1647	Serine aminopeptidase, S33
C0971_15570	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0971_15575	COG0148	phosphopyruvate hydratase activity
C0971_15580	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C0971_15585	COG0149	triose-phosphate isomerase activity
C0971_15590	COG0126	phosphoglycerate kinase activity
C0971_15595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0971_15610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C0971_15685	COG3953	SLT domain
C0971_15685	COG5280	Phage tail tape measure protein TP901
C0971_15730	COG0740	serine-type endopeptidase activity
C0971_15825	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C0971_15845	COG1484	DNA-dependent DNA replication
C0971_15850	COG3935	DnaD domain protein
C0971_15855	COG3723	Recombinational DNA repair protein, rece pathway
C0971_15860	COG5377	YqaJ viral recombinase family
C0971_15890	COG1396	sequence-specific DNA binding
C0971_15895	COG1525	nuclease
C0971_15915	COG0740	serine-type endopeptidase activity
C0971_15920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0971_15925	COG1481	regulation of sporulation
C0971_15930	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C0971_15935	COG1660	Displays ATPase and GTPase activities
C0971_15940	COG1051	belongs to the nudix hydrolase family
C0971_15945	COG0492	ferredoxin-NADP+ reductase activity
C0971_15950	COG0457	Tetratricopeptide repeat
C0971_15955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0971_15955	COG0140	phosphoribosyl-ATP diphosphatase activity
C0971_15960	COG0107	imidazoleglycerol-phosphate synthase activity
C0971_15965	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C0971_15970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0971_15975	COG0131	Imidazoleglycerol-phosphate dehydratase
C0971_15980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C0971_15985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C0971_15990	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C0971_15995	COG0110	maltose O-acetyltransferase activity
C0971_16005	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C0971_16015	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C0971_16020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C0971_16025	COG0363	glucosamine-6-phosphate deaminase activity
C0971_16035	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C0971_16040	COG1950	PFAM Membrane protein of
C0971_16045	COG3595	metallopeptidase activity
C0971_16050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0971_16055	COG0556	nucleotide-excision repair
C0971_16065	COG4897	Protein conserved in bacteria
C0971_16070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0971_16075	COG1309	transcriptional regulator
C0971_16090	COG2318	DinB family
C0971_16100	COG0531	amino acid
C0971_16105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0971_16110	COG0793	Belongs to the peptidase S41A family
C0971_16110	COG3409	Peptidoglycan-binding domain 1 protein
C0971_16115	COG1733	regulation of RNA biosynthetic process
C0971_16120	COG3883	PFAM NLP P60 protein
C0971_16120	COG0791	NLP P60 protein
C0971_16125	COG2177	Part of the ABC transporter FtsEX involved in
C0971_16130	COG2884	Cell division ATP-binding protein ftsE
C0971_16140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C0971_16150	COG0653	protein targeting
C0971_16155	COG3012	SEC-C Motif Domain Protein
C0971_16155	COG1405	negative regulation of cell septum assembly
C0971_16160	COG2059	Chromate
C0971_16165	COG2059	Chromate
C0971_16180	COG1516	flagellar protein fliS
C0971_16185	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C0971_16190	COG1334	flagellar protein FlaG
C0971_16210	COG4974	Belongs to the 'phage' integrase family
C0971_16235	COG0358	DNA primase activity
C0971_16265	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C0971_16270	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C0971_16280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0971_16285	COG1256	bacterial-type flagellum assembly
C0971_16285	COG4786	Flagellar basal body rod
C0971_16305	COG1040	competence protein
C0971_16310	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C0971_16320	COG1307	EDD domain protein, DegV family
C0971_16325	COG2197	response regulator
C0971_16330	COG4585	Histidine kinase
C0971_16335	COG1739	Uncharacterized protein family UPF0029
C0971_16340	COG1316	TRANSCRIPTIONal
C0971_16345	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0971_16355	COG2385	sporulation resulting in formation of a cellular spore
C0971_16355	COG2247	cell wall binding repeat
C0971_16360	COG0438	transferase activity, transferring glycosyl groups
C0971_16365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0971_16370	COG0438	transferase activity, transferring glycosyl groups
C0971_16395	COG2171	N-acyltransferase activity
C0971_16405	COG0673	inositol 2-dehydrogenase activity
C0971_16420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0971_16425	COG0653	protein targeting
C0971_16435	COG0791	NLP P60 protein
C0971_16435	COG1388	LysM domain
C0971_16450	COG2340	Cysteine-rich secretory protein family
C0971_16455	COG1696	Membrane protein involved in D-alanine export
C0971_16500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C0971_16515	COG2199	diguanylate cyclase activity
C0971_16515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C0971_16535	COG0840	transmembrane signaling receptor activity
C0971_16575	COG0431	NADPH-dependent FMN reductase
C0971_16585	COG2144	transferase activity, transferring acyl groups
C0971_16590	COG0438	transferase activity, transferring glycosyl groups
C0971_16610	COG2153	protein acetylation
C0971_16620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0971_16635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C0971_16640	COG4521	taurine ABC transporter
C0971_16650	COG2175	clavaminate synthase activity
C0971_16655	COG2076	Multidrug Resistance protein
C0971_16660	COG1028	Short-chain dehydrogenase reductase Sdr
C0971_16675	COG0697	spore germination
C0971_16690	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C0971_16690	COG0662	Cupin 2, conserved barrel domain protein
C0971_16710	COG0830	nickel cation binding
C0971_16715	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C0971_16720	COG0804	urea catabolic process
C0971_16725	COG0832	Belongs to the urease beta subunit family
C0971_16730	COG0831	urea catabolic process
C0971_16740	COG0411	ABC transporter
C0971_16760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0971_16785	COG0110	maltose O-acetyltransferase activity
C0971_16790	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C0971_16820	COG0438	transferase activity, transferring glycosyl groups
C0971_16835	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0971_16850	COG4464	protein tyrosine phosphatase activity
C0971_16855	COG0489	protein tyrosine kinase activity
C0971_16860	COG3944	biosynthesis protein
C0971_16885	COG1192	Involved in chromosome partitioning
C0971_16895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0971_16900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0971_16955	COG2385	sporulation resulting in formation of a cellular spore
C0971_16955	COG2247	cell wall binding repeat
C0971_16965	COG2207	Transcriptional regulator
C0971_16970	COG2814	Major facilitator Superfamily
C0971_16975	COG0656	L-ascorbic acid biosynthetic process
C0971_16980	COG3189	MarR family transcriptional regulator
C0971_17035	COG4974	Belongs to the 'phage' integrase family
C0971_17040	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C0971_17065	COG4974	Belongs to the 'phage' integrase family
C0971_17095	COG0793	Belongs to the peptidase S41A family
C0971_17105	COG1388	LysM domain
C0971_17105	COG0791	NLP P60 protein
C0971_17115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0971_17140	COG1012	belongs to the aldehyde dehydrogenase family
C0971_17145	COG0861	Integral membrane protein TerC family
C0971_17155	COG0629	single-stranded DNA binding
C0971_17185	COG4786	Flagellar basal body rod
C0971_17190	COG4786	Flagellar basal body rod
C0971_17195	COG1077	Cell shape determining protein MreB Mrl
C0971_17200	COG1609	Transcriptional regulator
C0971_17205	COG0739	heme binding
C0971_17230	COG3290	protein histidine kinase activity
C0971_17240	COG2385	sporulation resulting in formation of a cellular spore
C0971_17255	COG4836	Membrane
C0971_17260	COG1007	ATP synthesis coupled electron transport
C0971_17265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0971_17270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0971_17275	COG0713	ATP synthesis coupled electron transport
C0971_17280	COG0839	Belongs to the complex I subunit 6 family
C0971_17290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C0971_17300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0971_17305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0971_17310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0971_17315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C0971_17320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0971_17325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C0971_17330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C0971_17335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0971_17340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C0971_17345	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0971_17350	COG0356	it plays a direct role in the translocation of protons across the membrane
C0971_17365	COG1404	Belongs to the peptidase S8 family
C0971_17375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C0971_17390	COG0698	ribose 5-phosphate isomerase
C0971_17395	COG0840	transmembrane signaling receptor activity
C0971_17405	COG1971	Probably functions as a manganese efflux pump
C0971_17410	COG0009	L-threonylcarbamoyladenylate synthase
C0971_17420	COG2890	protein-(glutamine-N5) methyltransferase activity
C0971_17425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0971_17430	COG1435	thymidine kinase activity
C0971_17440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C0971_17445	COG1494	fructose-1,6-bisphosphatase
C0971_17450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0971_17455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0971_17460	COG0191	fructose-bisphosphate aldolase activity
C0971_17465	COG2204	response regulator
C0971_17470	COG4821	SIS domain
C0971_17475	COG0504	CTP synthase activity
C0971_17480	COG3343	RNA polymerase activity
C0971_17490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0971_17490	COG1703	isobutyryl-CoA mutase activity
C0971_17490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0971_17500	COG1960	acyl-CoA dehydrogenase activity
C0971_17505	COG1960	acyl-CoA dehydrogenase activity
C0971_17510	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0971_17515	COG0183	Belongs to the thiolase family
C0971_17520	COG0247	lactate metabolic process
C0971_17520	COG2181	nitrate reductase activity
C0971_17525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0971_17535	COG0018	arginyl-trna synthetase
C0971_17540	COG4506	Protein conserved in bacteria
C0971_17545	COG0010	Belongs to the arginase family
C0971_17550	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C0971_17555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0971_17565	COG1994	Peptidase M50
C0971_17575	COG3465	dGTPase activity
C0971_17580	COG1078	dGTPase activity
C0971_17585	COG4844	belongs to the
C0971_17600	COG0280	phosphate acetyltransferase
C0971_17605	COG3253	May function as heme-dependent peroxidase
C0971_17615	COG2363	Small membrane protein
C0971_17625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0971_17630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C0971_17635	COG0314	molybdopterin synthase activity
C0971_17640	COG0746	molybdenum cofactor guanylyltransferase activity
C0971_17645	COG0351	phosphomethylpyrimidine kinase
C0971_17650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0971_17655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0971_17665	COG1131	(ABC) transporter
C0971_17670	COG0842	Transport permease protein
C0971_17670	COG1511	domain protein
C0971_17700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C0971_17705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0971_17710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0971_17710	COG0723	plastoquinol--plastocyanin reductase activity
C0971_17715	COG0492	ferredoxin-NADP+ reductase activity
C0971_17730	COG2195	Cleaves the N-terminal amino acid of tripeptides
C0971_17740	COG3118	belongs to the thioredoxin family
C0971_17765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0971_17785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0971_17790	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C0971_17795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0971_17800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0971_17805	COG1120	ATPase activity
C0971_17825	COG1131	(ABC) transporter
C0971_17830	COG1309	transcriptional regulator
C0971_17835	COG3842	ATPase activity
C0971_17840	COG3833	ABC-type maltose transport systems, permease component
C0971_17860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C0971_17885	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C0971_17895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0971_17900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C0971_17905	COG4853	Protein conserved in bacteria
C0971_17910	COG4863	YycH protein
C0971_17915	COG5002	protein histidine kinase activity
C0971_17920	COG0745	RESPONSE REGULATOR receiver
C0971_17945	COG2814	Major facilitator Superfamily
C0971_17950	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C0971_17955	COG0305	Participates in initiation and elongation during chromosome replication
C0971_17960	COG0359	binds to the 23S rRNA
C0971_17965	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C0971_17970	COG4241	membrane
C0971_17980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C0971_17985	COG0629	single-stranded DNA binding
C0971_17990	COG0360	Binds together with S18 to 16S ribosomal RNA
C0971_17995	COG0438	transferase activity, transferring glycosyl groups
C0971_18005	COG0012	GTP binding
C0971_18010	COG4481	Protein conserved in bacteria
C0971_18015	COG0668	transmembrane transport
C0971_18030	COG1475	DNA binding
C0971_18035	COG1192	Involved in chromosome partitioning
C0971_18040	COG1475	DNA binding
C0971_18045	COG0357	Ribosomal RNA small subunit methyltransferase G
C0971_18050	COG0445	tRNA wobble uridine modification
C0971_18055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C0971_18060	COG1847	R3H domain protein
C0971_18070	COG0594	ribonuclease P activity
C0971_18075	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C0971_18085	COG1923	regulation of RNA biosynthetic process
C0971_18130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0971_18180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C0971_18185	COG0191	fructose-bisphosphate aldolase activity
C0971_18190	COG1494	fructose-1,6-bisphosphatase