locus-tag class description MLA2C4_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) MLA2C4_00015 ENOG410848D S4 domain protein YaaA MLA2C4_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MLA2C4_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) MLA2C4_00100 ENOG4105ZMH deoxynucleoside kinase MLA2C4_00110 ENOG4105GTG Isochorismatase MLA2C4_00115 ENOG4108Z6B deaminase MLA2C4_00125 ENOG4105C6E dna polymerase iii MLA2C4_00145 ENOG41067KS pro-sigma K processing MLA2C4_00180 ENOG4105CXN decarboxylase MLA2C4_00190 ENOG4105FA2 dna polymerase iii MLA2C4_00195 ENOG4105MA4 psp1 domain protein MLA2C4_00205 ENOG41060K3 Methyltransferase MLA2C4_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) MLA2C4_00220 ENOG4105KRN Transcriptional regulator, abrb family MLA2C4_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) MLA2C4_00230 ENOG4105F8V Hydrolase, tatD family MLA2C4_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) MLA2C4_00240 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) MLA2C4_00245 ENOG4105XFA sporulation peptidase YabG MLA2C4_00250 ENOG4105W42 Veg protein MLA2C4_00265 ENOG4105DFT pur operon repressor MLA2C4_00270 ENOG4105KME endoribonuclease L-psp MLA2C4_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase MLA2C4_00300 ENOG4108JA2 transcriptioN-repair coupling factor MLA2C4_00305 ENOG4108M14 stage v sporulation protein t MLA2C4_00315 ENOG4108IY2 MazG family MLA2C4_00320 ENOG41082I2 s4 domain protein MLA2C4_00325 ENOG4105VYY sporulation protein yabp MLA2C4_00340 ENOG41060GV RNA binding s1 domain protein MLA2C4_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase MLA2C4_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) MLA2C4_00385 ENOG4105C6T cysteine synthase MLA2C4_00390 ENOG4105CRQ synthase (Component I) MLA2C4_00395 ENOG4105DDQ anthranilate synthase MLA2C4_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 MLA2C4_00405 ENOG4105EEI dihydropteroate synthase MLA2C4_00410 ENOG4105KRF dihydroneopterin aldolase MLA2C4_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase MLA2C4_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) MLA2C4_00515 ENOG4108Z0C Uvrb UvrC protein MLA2C4_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) MLA2C4_00540 ENOG4105CTP PilT protein domain protein MLA2C4_00560 ENOG4105D7W serine acetyltransferase MLA2C4_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 MLA2C4_00580 ENOG4105M0M Tetracycline resistance protein MLA2C4_00585 ENOG4105QIV RNA polymerase MLA2C4_00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) MLA2C4_00615 ENOG4108VZM 50s ribosomal protein L10 MLA2C4_00620 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) MLA2C4_00625 ENOG4107Y49 methyltransferase MLA2C4_00640 ENOG4105XPM ribosomal protein MLA2C4_00730 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) MLA2C4_00750 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) MLA2C4_00765 ENOG4105VPB 50S ribosomal protein L30 MLA2C4_00775 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) MLA2C4_00785 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) MLA2C4_00795 ENOG41067V7 50S ribosomal protein L36 MLA2C4_00830 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) MLA2C4_00835 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) MLA2C4_00860 ENOG4105D1F ATP-binding protein MLA2C4_00875 ENOG4108NMV polysaccharide deacetylase MLA2C4_00955 ENOG4105C8B TIGR00159 family MLA2C4_00960 ENOG4107U5W ybbr family MLA2C4_00975 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) MLA2C4_01010 ENOG4108PSK reductase MLA2C4_01015 ENOG4108UMI ABC transporter, permease MLA2C4_01025 ENOG4105D01 (LipO)protein MLA2C4_01030 ENOG4105EE1 crotonyl-CoA reductase MLA2C4_01040 ENOG4105IQ5 FAD linked oxidase domain protein MLA2C4_01055 ENOG4105C2C drug resistance transporter, Bcr CflA MLA2C4_01080 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MLA2C4_01085 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MLA2C4_01090 ENOG4105C3U ABC transporter MLA2C4_01095 ENOG4108JQ7 (ABC) transporter MLA2C4_01125 ENOG4108J59 Extracellular solute-binding protein, family 5 MLA2C4_01130 ENOG4108J59 Extracellular solute-binding protein, family 5 MLA2C4_01150 ENOG4105E0C molybdate abc transporter MLA2C4_01155 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein MLA2C4_01160 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family MLA2C4_01190 ENOG4105F6E Acyl-transferase MLA2C4_01215 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) MLA2C4_01225 ENOG4108RE7 deoxyribonuclease MLA2C4_01235 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) MLA2C4_01255 ENOG4105C5H ABC transporter MLA2C4_01260 ENOG4105BZU Histidine kinase MLA2C4_01265 ENOG4105WH1 Two component transcriptional regulator luxr family MLA2C4_01270 ENOG4105CJ1 ABC, transporter MLA2C4_01275 ENOG41090VJ ABC-2 type transporter MLA2C4_01280 ENOG4108KYE ABC-2 type transporter MLA2C4_01290 ENOG4105DEF Extracellular solute-binding protein, family 5 MLA2C4_01295 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein MLA2C4_01305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MLA2C4_01310 ENOG4105C3U ABC transporter MLA2C4_01315 ENOG4108JQ7 (ABC) transporter MLA2C4_01320 ENOG410667J hydrolase MLA2C4_01355 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase MLA2C4_01360 ENOG4105ERH Fumarylacetoacetate hydrolase MLA2C4_01370 ENOG4105CUB amino acid MLA2C4_01380 ENOG4105CPF Cell wall formation (By similarity) MLA2C4_01385 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) MLA2C4_01410 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein MLA2C4_01415 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) MLA2C4_01425 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) MLA2C4_01530 ENOG4105K8N protein family UPF0079, ATPase MLA2C4_01535 ENOG41072GX Peptidase M22 Glycoprotease MLA2C4_01540 ENOG410801F ribosomal-protein-alanine acetyltransferase MLA2C4_01545 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) MLA2C4_01550 ENOG4105C5H ABC transporter MLA2C4_01565 ENOG4108TYN CAAX amino terminal protease family protein MLA2C4_01575 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) MLA2C4_01580 ENOG4108IBT Inherit from COG: transposase MLA2C4_01595 ENOG4105C7N Xanthine uracil vitamin C permease MLA2C4_01605 ENOG4105BZU Histidine kinase MLA2C4_01630 ENOG4107ZXU DSBA oxidoreductase MLA2C4_01675 ENOG4108SHN Glycosyl transferase, family 2 MLA2C4_01695 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MLA2C4_01720 ENOG4105SX7 Transporter MLA2C4_01745 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) MLA2C4_01750 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit MLA2C4_01755 ENOG4105C83 adenylosuccinate lyase MLA2C4_01765 ENOG4105VR9 phosphoribosylformylglycinamidine synthase MLA2C4_01790 ENOG4108V3E phosphoribosylglycinamide formyltransferase MLA2C4_01800 ENOG4105C12 Phosphoribosylglycinamide synthetase MLA2C4_01830 ENOG4105C4R Atp-dependent dna helicase MLA2C4_01855 ENOG4108W2Y isochorismatase MLA2C4_01870 ENOG4108UMI ABC transporter, permease MLA2C4_01875 ENOG4105D01 (LipO)protein MLA2C4_01895 ENOG410834F Transcriptional regulator MLA2C4_01900 ENOG4107I77 yiaA/B two helix domain MLA2C4_01920 ENOG4105CBD Diacylglycerol kinase MLA2C4_01925 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) MLA2C4_01930 ENOG4108JPW Aminotransferase MLA2C4_01940 ENOG4105C26 Dehydrogenase MLA2C4_01945 ENOG4105KPY Small multidrug resistance protein MLA2C4_01965 ENOG4105D9N nucleoside MLA2C4_01970 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) MLA2C4_01980 ENOG4105BZU Histidine kinase MLA2C4_01985 ENOG4108W15 Protein of unknown function (DUF1456) MLA2C4_02000 ENOG4105DTQ mandelate racemase muconate lactonizing MLA2C4_02010 ENOG4105DFD Na H antiporter MLA2C4_02030 ENOG4105D3R alkyl hydroperoxide reductase MLA2C4_02035 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) MLA2C4_02040 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) MLA2C4_02045 ENOG4107W7X Aldolase MLA2C4_02055 ENOG4105EHG Permease protein MLA2C4_02060 ENOG4105DQ5 transport system permease protein MLA2C4_02065 ENOG4108V5C ABC transporter MLA2C4_02075 ENOG4105CAY ferredoxin--nadp reductase MLA2C4_02095 ENOG4106UIA MLA2C4_02100 ENOG4106UIA MLA2C4_02135 ENOG410756H nucleotidyltransferase MLA2C4_02140 ENOG4105D2S major facilitator superfamily MLA2C4_02155 ENOG4105E5Q amino acid AbC transporter MLA2C4_02160 ENOG4105EAB amino acid AbC transporter MLA2C4_02180 ENOG4105C8Q Methyl-accepting chemotaxis MLA2C4_02195 ENOG4105CI1 PTS System MLA2C4_02215 ENOG4105C9U ATP-dependent DNA helicase RecQ MLA2C4_02240 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MLA2C4_02255 ENOG4108IUX (ABC) transporter MLA2C4_02260 ENOG4105RHA ABC transporter, permease MLA2C4_02290 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter MLA2C4_02305 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component MLA2C4_02325 ENOG4105C5H ABC transporter MLA2C4_02355 ENOG41062JF Transcriptional regulator MLA2C4_02375 ENOG4105DEU major facilitator superfamily MLA2C4_02405 ENOG4108N0M stress protein MLA2C4_02410 ENOG4106FN3 tellurium resistance protein MLA2C4_02415 ENOG4106FN3 tellurium resistance protein MLA2C4_02420 ENOG4107TS3 membrane protein, TerC MLA2C4_02425 ENOG4108TTB tellurium resistance protein MLA2C4_02445 ENOG4105KJF protein tyrosine phosphatase MLA2C4_02455 ENOG4107U9T Pfam:Ribonuclease_BN MLA2C4_02460 ENOG4105C59 p-type ATPase MLA2C4_02465 ENOG4108IPJ Membrane MLA2C4_02475 ENOG4105C3F Signal peptidase i MLA2C4_02485 ENOG4107ZTW SNARE associated Golgi MLA2C4_02500 ENOG410606W general stress protein MLA2C4_02510 ENOG4105UPD Calcium Proton MLA2C4_02560 ENOG4108JUB Transcriptional regulator MLA2C4_02570 ENOG4108IQI permease MLA2C4_02595 ENOG4105CSV Glutaminase MLA2C4_02605 ENOG4108A04 Beta-lactamase MLA2C4_02625 ENOG4105CKK Glycosyl transferase, family 2 MLA2C4_02630 ENOG4107QQG Dehydrogenase MLA2C4_02635 ENOG4105C3I Nad-dependent epimerase dehydratase MLA2C4_02640 ENOG4105CKK Glycosyl transferase, family 2 MLA2C4_02650 ENOG4105F1A Pyruvate formate-lyase MLA2C4_02670 ENOG4105CI2 imidazolone-5-propionate hydrolase MLA2C4_02675 ENOG4105ECP epimerase MLA2C4_02705 ENOG41067AE Membrane-bound metal-dependent hydrolase MLA2C4_02710 ENOG4105CEN a g-specific adenine glycosylase MLA2C4_02715 ENOG4106BXE MLA2C4_02740 ENOG4105BZ1 (ABC) transporter MLA2C4_02745 ENOG4107NBY Membrane MLA2C4_02750 ENOG4105CBC glutamate synthase MLA2C4_02760 ENOG4108IUW ABC transporter MLA2C4_02780 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MLA2C4_02785 ENOG4105G5W regulator Fur family MLA2C4_02900 ENOG4108JQC penicillin-binding protein 1A MLA2C4_02905 ENOG4108R9S DSBA oxidoreductase MLA2C4_02920 ENOG4105D7V transposase MLA2C4_02930 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) MLA2C4_02940 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) MLA2C4_02945 ENOG4105BZU Histidine kinase MLA2C4_02950 ENOG4105CYN Serine protein kinase MLA2C4_02970 ENOG4105C94 Transporter MLA2C4_02985 ENOG4105DZ6 Band 7 protein MLA2C4_02995 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism MLA2C4_03000 ENOG4108V9W transcriptional regulatory protein MLA2C4_03005 ENOG4105D4T Citrate transporter MLA2C4_03035 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) MLA2C4_03040 ENOG4108STX response regulator MLA2C4_03045 ENOG4105US7 Histidine kinase MLA2C4_03070 ENOG4108MRH transcriptional regulatory protein MLA2C4_03080 ENOG4105C6K Malic enzyme MLA2C4_03090 ENOG4108UZ3 Transporter MLA2C4_03095 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MLA2C4_03105 ENOG4105BZU Histidine kinase MLA2C4_03110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MLA2C4_03115 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MLA2C4_03120 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) MLA2C4_03125 ENOG4108JB9 formate dehydrogenase MLA2C4_03145 ENOG4105CUB amino acid MLA2C4_03155 ENOG4105C59 p-type ATPase MLA2C4_03160 ENOG4105DAP Nicotinate phosphoribosyltransferase MLA2C4_03190 ENOG41073R8 VanW family MLA2C4_03195 ENOG4108KGH TRANSCRIPTIONal MLA2C4_03200 ENOG4105D9N nucleoside MLA2C4_03205 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase MLA2C4_03210 ENOG4105C37 (CBS) domain MLA2C4_03215 ENOG4108IJ0 Aspartate ammonia-lyase MLA2C4_03220 ENOG4105DAA L-lactate MLA2C4_03235 ENOG4105DUX Transporter MLA2C4_03240 ENOG4108MES Periplasmic binding protein MLA2C4_03245 ENOG4105DQ5 transport system permease protein MLA2C4_03250 ENOG4108IHU transport system permease protein MLA2C4_03255 ENOG4105E0A ABC, transporter MLA2C4_03260 ENOG4105DMQ Methyltransferase MLA2C4_03270 ENOG4105EXW epimerase dehydratase MLA2C4_03280 ENOG4107T89 von Willebrand factor, type A MLA2C4_03285 ENOG4105GMT ATPase associated with various cellular activities aaa_5 MLA2C4_03290 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) MLA2C4_03305 ENOG4105BZU Histidine kinase MLA2C4_03310 ENOG4105D5Q Arginine ornithine antiporter MLA2C4_03315 ENOG4107414 GntR family transcriptional regulator MLA2C4_03320 ENOG4105C5Y PTS System MLA2C4_03325 ENOG4105CG3 alpha amylase, catalytic region MLA2C4_03340 ENOG4105E1K spore germination protein MLA2C4_03345 ENOG4108XG2 Histidine kinase MLA2C4_03350 ENOG4105WH1 Two component transcriptional regulator luxr family MLA2C4_03355 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin MLA2C4_03370 ENOG4105CRN Aminoglycoside phosphotransferase MLA2C4_03375 ENOG4105BZG amino acid carrier protein MLA2C4_03380 ENOG4105CDA abc transporter atp-binding protein MLA2C4_03385 ENOG4105CT1 (ABC) transporter MLA2C4_03390 ENOG4105EAD ABC transporter MLA2C4_03395 ENOG4105DRP amino acid AbC transporter MLA2C4_03400 ENOG4108IQI permease MLA2C4_03425 ENOG4105D29 Helix-turn-helix type 11 domain protein MLA2C4_03430 ENOG4105NAE bifunctional deaminase-reductase domain protein MLA2C4_03435 ENOG4105BZU Histidine kinase MLA2C4_03450 ENOG4105CHH sulfate transporter MLA2C4_03455 ENOG41068KF Universal stress protein MLA2C4_03475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MLA2C4_03480 ENOG4108JQ7 (ABC) transporter MLA2C4_03490 ENOG4105CXY transporter MLA2C4_03495 ENOG41067TZ transcriptional regulator, MarR family MLA2C4_03500 ENOG4105C0R drug resistance transporter emrb qaca subfamily MLA2C4_03505 ENOG4105ETE Transcriptional regulator (LacI family MLA2C4_03510 ENOG4108RVA ribokinase MLA2C4_03520 ENOG4105C2J ABC transporter MLA2C4_03525 ENOG4105CNN ABC, transporter MLA2C4_03530 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator MLA2C4_03535 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) MLA2C4_03595 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) MLA2C4_03600 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer MLA2C4_03605 ENOG41069ER domain protein MLA2C4_03610 ENOG4105VZ8 Transcriptional regulator MLA2C4_03615 ENOG4107D63 MLA2C4_03630 ENOG4105DUX Transporter MLA2C4_03650 ENOG4105C85 amino acid MLA2C4_03655 ENOG4105C7N Xanthine uracil vitamin C permease MLA2C4_03670 ENOG4105MA6 gCN5-related N-acetyltransferase MLA2C4_03690 ENOG4105CCU oxidase (Subunit III) MLA2C4_03695 ENOG4105BZ9 Cytochrome C oxidase, subunit I MLA2C4_03700 ENOG4105E2S oxidase) subunit II MLA2C4_03720 ENOG4106CAD Protein of unknown function (DUF3311) MLA2C4_03725 ENOG4105E1V na solute symporter MLA2C4_03740 ENOG4108NHD germination protein MLA2C4_03745 ENOG4105CE1 Ferrous iron transport protein b MLA2C4_03750 ENOG4105CE1 Ferrous iron transport protein b MLA2C4_03755 ENOG4105CE1 Ferrous iron transport protein b MLA2C4_03760 ENOG4105CVA phosphate MLA2C4_03765 ENOG4105C8U phosphate abc transporter MLA2C4_03770 ENOG4105E2Z phosphate ABC transporter (Permease MLA2C4_03900 ENOG41080XQ Signal transduction protein with cbs domains MLA2C4_03920 ENOG4105ETU transcriptional activator (TenA MLA2C4_03930 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component MLA2C4_03940 ENOG4108VEU Thiamine monophosphate synthase MLA2C4_03945 ENOG41080HI glycine oxidase MLA2C4_03960 ENOG4105D06 uba thif-type nad fad binding protein MLA2C4_03965 ENOG4105DWF phosphomethylpyrimidine kinase MLA2C4_04015 ENOG4108INS Transcriptional regulator MLA2C4_04040 ENOG4105C19 ABC transporter MLA2C4_04050 ENOG4105C7N Xanthine uracil vitamin C permease MLA2C4_04060 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein MLA2C4_04075 ENOG4105K63 Thioredoxin MLA2C4_04095 ENOG4108B31 Spore germination protein MLA2C4_04115 ENOG4107Y03 Nitroreductase MLA2C4_04130 ENOG4107YTP response regulator receiver protein MLA2C4_04160 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) MLA2C4_04165 ENOG4107Y5K Resolvase MLA2C4_04240 ENOG4108TCS Glutamyl endopeptidase MLA2C4_04265 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase MLA2C4_04270 ENOG4105XTG Pfam:DUF156 MLA2C4_04280 ENOG4107TPS domain protein MLA2C4_04285 ENOG4105VFE sira family MLA2C4_04290 ENOG4105VFE sira family MLA2C4_04295 ENOG41085GJ domain protein MLA2C4_04300 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase MLA2C4_04305 ENOG41087NI Sulfite exporter TauE/SafE MLA2C4_04315 ENOG4108KGH TRANSCRIPTIONal MLA2C4_04345 ENOG4105EMD TRANSCRIPTIONal MLA2C4_04350 ENOG4105VCP PTS System MLA2C4_04355 ENOG4105VZJ PTS System MLA2C4_04375 ENOG41069ER domain protein MLA2C4_04380 ENOG4107RBB ABC transporter, permease MLA2C4_04385 ENOG4105C19 ABC transporter MLA2C4_04415 ENOG4105WEF catalase MLA2C4_04450 ENOG4107T5V SNARE associated Golgi MLA2C4_04480 ENOG4105CUB amino acid MLA2C4_04490 ENOG4107RWR Sodium hydrogen exchanger MLA2C4_04500 ENOG4106KNT transcriptional regulator MLA2C4_04535 ENOG4108PCN EamA-like transporter family MLA2C4_04540 ENOG4108YXU transcriptional regulator AsnC family MLA2C4_04560 ENOG4105KPY Small multidrug resistance protein MLA2C4_04565 ENOG4105KPY Small multidrug resistance protein MLA2C4_04590 ENOG4105NF4 modulator of drug activity MLA2C4_04600 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) MLA2C4_04605 ENOG4105E5W Transporter MLA2C4_04615 ENOG4107RKG DJ-1/PfpI family MLA2C4_04625 ENOG4105D5Q Arginine ornithine antiporter MLA2C4_04630 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) MLA2C4_04635 ENOG4105C26 Dehydrogenase MLA2C4_04645 ENOG4105BZ1 (ABC) transporter MLA2C4_04650 ENOG4105BZ1 (ABC) transporter MLA2C4_04665 ENOG4105DRP amino acid AbC transporter MLA2C4_04670 ENOG4105CDA abc transporter atp-binding protein MLA2C4_04685 ENOG410839P MLA2C4_04720 ENOG4107FQX Alpha-acetolactate decarboxylase MLA2C4_04745 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase MLA2C4_04750 ENOG4105D4P Coproporphyrinogen iii oxidase MLA2C4_04755 ENOG4105CEY Amp-dependent synthetase and ligase MLA2C4_04765 ENOG4105CHH sulfate transporter MLA2C4_04810 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein MLA2C4_04815 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein MLA2C4_04830 ENOG4105CGU Enoyl-CoA hydratase MLA2C4_04850 ENOG4105DER m42 family MLA2C4_04910 ENOG4105CSH Transporter MLA2C4_04920 ENOG4108MRH transcriptional regulatory protein MLA2C4_04985 ENOG4105CDU Replicative dna helicase MLA2C4_05005 ENOG4105CDU Replicative dna helicase MLA2C4_05030 ENOG4105C0R drug resistance transporter emrb qaca subfamily MLA2C4_05080 ENOG4108D32 Methyltransferase MLA2C4_05100 ENOG4105CID antiterminator MLA2C4_05105 ENOG4105C5Y PTS System MLA2C4_05110 ENOG4105CS2 ec 3.2.1.21 MLA2C4_05120 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase MLA2C4_05135 ENOG4105F27 Major Facilitator MLA2C4_05140 ENOG4105WAB arsR family transcriptional regulator MLA2C4_05165 ENOG4108NIW Leucine export protein LeuE MLA2C4_05170 ENOG4105CMT Dihydroxyacetone kinase MLA2C4_05185 ENOG4105CMT Dihydroxyacetone kinase MLA2C4_05195 ENOG410847I Transcriptional regulator, BadM Rrf2 family MLA2C4_05245 ENOG4105FBW Monooxygenase MLA2C4_05270 ENOG4108WC5 Alpha Beta Hydrolase Fold protein MLA2C4_05310 ENOG4105WN5 stage II sporulation protein MLA2C4_05320 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MLA2C4_05330 ENOG4108MJI response regulator MLA2C4_05335 ENOG4105BZU Histidine kinase MLA2C4_05340 ENOG4105BZU Histidine kinase MLA2C4_05380 ENOG4105ENE Histidine kinase MLA2C4_05385 ENOG4108VB1 regulatoR MLA2C4_05415 ENOG4107VRP DNA repair exonuclease MLA2C4_05420 ENOG4106D4I domain protein MLA2C4_05470 ENOG4108MUZ hydrolase MLA2C4_05500 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator MLA2C4_05515 ENOG4105C6V Glycerol-3-phosphate dehydrogenase MLA2C4_05525 ENOG4105EMN RNA polymerase sigma factor MLA2C4_05535 ENOG4105CNI cell division protein FtsW MLA2C4_05545 ENOG4105EEM helicase MLA2C4_05555 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) MLA2C4_05580 ENOG4105K59 histidine triad (HIT) protein MLA2C4_05655 ENOG410905X membrane-flanked domain protein MLA2C4_05660 ENOG4105CKV Membrane MLA2C4_05685 ENOG410905X membrane-flanked domain protein MLA2C4_05690 ENOG4105CKV Membrane MLA2C4_05695 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation MLA2C4_05700 ENOG4105BZ4 penicillin-binding protein MLA2C4_05710 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) MLA2C4_05715 ENOG4105C1Q protoporphyrinogen oxidase MLA2C4_05740 ENOG4105NA0 Transcriptional regulator MLA2C4_05755 ENOG4105ECB domain protein MLA2C4_05770 ENOG4108MK9 spermidine N(1)-acetyltransferase MLA2C4_05780 ENOG4105D29 Helix-turn-helix type 11 domain protein MLA2C4_05790 ENOG4106AXD MLA2C4_05795 ENOG4108RQ5 Beta-lactamase domain-containing protein MLA2C4_05800 ENOG4105DF9 Lipoate-protein, ligase MLA2C4_05810 ENOG4105CEY Amp-dependent synthetase and ligase MLA2C4_05830 ENOG4105ENX hydrolase MLA2C4_05835 ENOG4107RN3 metallophosphoesterase MLA2C4_05840 ENOG4107TVP HD domain protein MLA2C4_05845 ENOG4107YPT transcriptional regulator MLA2C4_05850 ENOG4105C57 major facilitator superfamily MLA2C4_05860 ENOG4108AEY RNA polymerase sigma factor MLA2C4_05870 ENOG41086D8 Transcriptional regulator MLA2C4_05880 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MLA2C4_05905 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 MLA2C4_05910 ENOG4105C8Q Methyl-accepting chemotaxis MLA2C4_05930 ENOG4105ZU5 s-layer protein MLA2C4_05935 ENOG4107QP3 malate synthase g MLA2C4_05950 ENOG4105VEQ Cold shock protein MLA2C4_06040 ENOG4105ERH Fumarylacetoacetate hydrolase MLA2C4_06065 ENOG4105CAQ asparagine synthetase MLA2C4_06075 ENOG4105CH6 catalase MLA2C4_06085 ENOG4105BZU Histidine kinase MLA2C4_06095 ENOG4107A6P MLA2C4_06115 ENOG4105QNR S1 RNA binding domain protein MLA2C4_06120 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) MLA2C4_06130 ENOG4107AYK membrAne MLA2C4_06135 ENOG41073B9 MLA2C4_06145 ENOG4108KP7 hydrolase MLA2C4_06180 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) MLA2C4_06185 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) MLA2C4_06200 ENOG4105C31 Tryptophanyl-tRNA synthetase MLA2C4_06220 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MLA2C4_06225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MLA2C4_06235 ENOG4108JQ7 (ABC) transporter MLA2C4_06240 ENOG4105UQX Mate efflux family protein MLA2C4_06260 ENOG4108ZCF integral membrane protein MLA2C4_06270 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) MLA2C4_06280 ENOG4105DPN Oligoendopeptidase f MLA2C4_06290 ENOG4108Z18 K06886 hemoglobin MLA2C4_06295 ENOG4105MIX Adenylate cyclase MLA2C4_06310 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) MLA2C4_06315 ENOG4105EMS pseudouridine synthase MLA2C4_06335 ENOG4105K64 Glycosyl transferase, family 2 MLA2C4_06355 ENOG4107TVC Glycosyl transferase, family 2 MLA2C4_06375 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) MLA2C4_06380 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase MLA2C4_06390 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase MLA2C4_06480 ENOG4105CK7 Sodium proline symporter MLA2C4_06490 ENOG4105CRQ synthase (Component I) MLA2C4_06495 ENOG4105DDQ anthranilate synthase MLA2C4_06570 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MLA2C4_06590 ENOG4105C7S Dehydrogenase MLA2C4_06600 ENOG4105VZ8 Transcriptional regulator MLA2C4_06710 ENOG4105W5Q DNA repair protein (RadC MLA2C4_06740 ENOG4105VTR Integrase MLA2C4_06745 ENOG4107QYX exodeoxyribonuclease v alpha MLA2C4_06795 ENOG4105DZ1 carboxypeptidase MLA2C4_06800 ENOG4105VFR signal peptidase MLA2C4_06835 ENOG4105C26 Dehydrogenase MLA2C4_06845 ENOG4105F38 ABC transporter, permease MLA2C4_06850 ENOG4105D38 putrescine abc transporter MLA2C4_06855 ENOG4107RUE extracellular solute-binding protein family 1 MLA2C4_06865 ENOG4105EYF MMPL domain protein MLA2C4_06875 ENOG4108YBP pseudouridine synthase MLA2C4_06885 ENOG4105K4I Scp-like extracellular MLA2C4_06890 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) MLA2C4_06895 ENOG4105CQB FAD linked oxidase domain protein MLA2C4_06910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MLA2C4_06915 ENOG4105BZU Histidine kinase MLA2C4_06920 ENOG4105JXH GntR family transcriptional regulator MLA2C4_06940 ENOG4106A3R peptidase MLA2C4_06950 ENOG4108QTI )-transporter MLA2C4_06955 ENOG4107TS3 membrane protein, TerC MLA2C4_06965 ENOG410681C small acid-soluble spore protein MLA2C4_06970 ENOG4108Z7G MaoC domain protein dehydratase MLA2C4_06990 ENOG4105CHR reductase MLA2C4_07020 ENOG4105C4Y ABC transporter MLA2C4_07025 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MLA2C4_07030 ENOG4107RCV ABC transporter, permease MLA2C4_07050 ENOG4105E98 transcriptional regulator DeoR family MLA2C4_07060 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) MLA2C4_07070 ENOG4105PXI polysaccharide deacetylase MLA2C4_07080 ENOG4105BZU Histidine kinase MLA2C4_07085 ENOG41090MY MarR family Transcriptional regulator MLA2C4_07095 ENOG4106DF1 MLA2C4_07105 ENOG4105BZU Histidine kinase MLA2C4_07115 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase MLA2C4_07120 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) MLA2C4_07165 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) MLA2C4_07180 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) MLA2C4_07185 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family MLA2C4_07190 ENOG4105CZV ABC transporter MLA2C4_07200 ENOG4105CJ1 ABC, transporter MLA2C4_07240 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A MLA2C4_07250 ENOG4105D7V transposase MLA2C4_07255 ENOG4105EA8 2-Nitropropane dioxygenase MLA2C4_07260 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD MLA2C4_07270 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein MLA2C4_07290 ENOG4105NQC Flavodoxin MLA2C4_07320 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) MLA2C4_07350 ENOG4105CZN Potassium uptake protein MLA2C4_07355 ENOG41063Y9 MLA2C4_07360 ENOG4105KBJ sporulation protein ytfj MLA2C4_07385 ENOG4105CM2 brancheD-chain amino acid aminotransferase MLA2C4_07390 ENOG4105C7K acetolactate synthase MLA2C4_07395 ENOG4108ZP8 Acetolactate synthase small subunit MLA2C4_07470 ENOG4107RVV histidinol phosphate phosphatase, hisj family MLA2C4_07485 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase MLA2C4_07490 ENOG4105E0M Sulfatase MLA2C4_07500 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) MLA2C4_07520 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) MLA2C4_07525 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) MLA2C4_07535 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) MLA2C4_07540 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein MLA2C4_07545 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein MLA2C4_07555 ENOG4105C8J )-transporter MLA2C4_07575 ENOG4105DFD Na H antiporter MLA2C4_07595 ENOG4105ENE Histidine kinase MLA2C4_07600 ENOG4105WH1 Two component transcriptional regulator luxr family MLA2C4_07620 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) MLA2C4_07665 ENOG4105CJ3 phosphate transporter MLA2C4_07670 ENOG4107GRR phosphate transport regulator MLA2C4_07675 ENOG4105BZ4 penicillin-binding protein MLA2C4_07690 ENOG4105BZU Histidine kinase MLA2C4_07695 ENOG4105I3N Conserved Protein MLA2C4_07710 ENOG4105BZU Histidine kinase MLA2C4_07740 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) MLA2C4_07745 ENOG4105DZ1 carboxypeptidase MLA2C4_07750 ENOG4108JIC nucleoside recognition domain protein MLA2C4_07760 ENOG4105FE9 pseudouridine synthase MLA2C4_07770 ENOG4107TWT Cytochrome c biogenesis protein MLA2C4_07775 ENOG4105CRE cytochrome C MLA2C4_07780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MLA2C4_07785 ENOG4105BZU Histidine kinase MLA2C4_07790 ENOG4108WBT adenosyltransferase MLA2C4_07805 ENOG4108SAX Membrane MLA2C4_07820 ENOG4105C9U ATP-dependent DNA helicase RecQ MLA2C4_07825 ENOG4105I7S Abortive infection protein MLA2C4_07835 ENOG4107RGJ metallophosphoesterase MLA2C4_07840 ENOG4107X2D transcriptional regulator, merr family MLA2C4_07845 ENOG4108S6Z Negative regulator of genetic competence MLA2C4_07870 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase MLA2C4_07875 ENOG4107RB3 L-asparaginase MLA2C4_07905 ENOG4105S2F MLA2C4_07910 ENOG41065D1 MLA2C4_07915 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) MLA2C4_07940 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) MLA2C4_07955 ENOG4105XXQ heptaprenyl diphosphate synthase component I MLA2C4_07965 ENOG4105EAH synthase MLA2C4_07990 ENOG41068YB TPR repeat-containing protein MLA2C4_08005 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) MLA2C4_08010 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) MLA2C4_08045 ENOG4108JYZ YitT family MLA2C4_08055 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase MLA2C4_08070 ENOG4105FJR Lmbe family MLA2C4_08075 ENOG4105CPK Glycosyl transferase (Group 1 MLA2C4_08110 ENOG4105DVT helicase MLA2C4_08115 ENOG4105YAC MLA2C4_08135 ENOG4105CSM endonuclease III MLA2C4_08145 ENOG4105BZ4 penicillin-binding protein MLA2C4_08185 ENOG4106F55 Protein of unknown function (DUF1273) MLA2C4_08200 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) MLA2C4_08210 ENOG4105DVT helicase MLA2C4_08215 ENOG4105CTD carboxy-peptidase MLA2C4_08225 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) MLA2C4_08235 ENOG4105C2W permease MLA2C4_08240 ENOG4105DHF Membrane MLA2C4_08245 ENOG410890F Dynamin family MLA2C4_08255 ENOG4108W0I acetyltransferase MLA2C4_08265 ENOG4105KHC sulfurtransferase MLA2C4_08290 ENOG4106032 Glutathionylspermidine synthase MLA2C4_08340 ENOG41081VK Ribonuclease MLA2C4_08405 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MLA2C4_08415 ENOG4107RWR Sodium hydrogen exchanger MLA2C4_08420 ENOG4105CN5 Metallo-Beta-Lactamase MLA2C4_08425 ENOG4108Z5V transcriptional regulator, merr family MLA2C4_08435 ENOG4105H67 Protein of unknown function (DUF421) MLA2C4_08440 ENOG41080C8 DUF218 domain MLA2C4_08505 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) MLA2C4_08515 ENOG4107R0U MotA TolQ exbB proton channel MLA2C4_08520 ENOG4105ER2 Ompa motb domain protein MLA2C4_08525 ENOG4107YTP response regulator receiver protein MLA2C4_08530 ENOG4105CBS Chea signal transduction histidine kinase MLA2C4_08535 ENOG4105DD5 Flagellar motor switch protein MLA2C4_08550 ENOG4105BZU Histidine kinase MLA2C4_08570 ENOG4105E1Q flagellar hook-associated protein MLA2C4_08575 ENOG4105DTJ flagellar hook-associated protein MLA2C4_08580 ENOG4107TPX flagellar hook-associated MLA2C4_08595 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) MLA2C4_08600 ENOG4108ZC9 flagellar basal-body rod protein flgc MLA2C4_08605 ENOG41075Z6 flagellar hook-basal body complex protein fliE MLA2C4_08610 ENOG4107U2N Flagellar M-ring protein MLA2C4_08615 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) MLA2C4_08645 ENOG4105BZE flagellar hook protein, FlgE MLA2C4_08660 ENOG4107R88 Chemotaxis protein (CheV) MLA2C4_08670 ENOG4105I03 Flagellin MLA2C4_08675 ENOG4105I03 Flagellin MLA2C4_08675 ENOG4105I03 Flagellin MLA2C4_08680 ENOG4105E4C Lytic transglycosylase catalytic MLA2C4_08690 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) MLA2C4_08695 ENOG4105DD5 Flagellar motor switch protein MLA2C4_08705 ENOG4105CN7 Flagellar biosynthetic protein FliP MLA2C4_08710 ENOG4105VS8 Flagellar biosynthetic protein fliq MLA2C4_08720 ENOG4105D00 flagellar biosynthetic protein flhB MLA2C4_08725 ENOG4105D7B Flagellar biosynthesis protein flha MLA2C4_08730 ENOG4105FZW flagellar biosynthesis regulator FlhF MLA2C4_08735 ENOG4105KTQ flagellar basal-body rod protein MLA2C4_08740 ENOG4105CPU Monooxygenase MLA2C4_08785 ENOG4105KAC Antibiotic biosynthesis monooxygenase MLA2C4_08790 ENOG4107QZ7 Cellulose synthase catalytic subunit MLA2C4_08810 ENOG4108U4N (sortase) family MLA2C4_08835 ENOG4105DUM transcriptional regulator, lysR family MLA2C4_08840 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MLA2C4_08845 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein MLA2C4_08850 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component MLA2C4_08905 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) MLA2C4_08925 ENOG4105CAQ asparagine synthetase MLA2C4_08945 ENOG4105PGM cation diffusion facilitator family transporter MLA2C4_08955 ENOG4105DRR Transcriptional regulator, GntR family MLA2C4_08960 ENOG4108UZ3 Transporter MLA2C4_08970 ENOG4105DFD Na H antiporter MLA2C4_08975 ENOG4105C9Q fumarate hydratase class II MLA2C4_08990 ENOG4105C5X domain protein MLA2C4_09000 ENOG4107QJQ Mate efflux family protein MLA2C4_09005 ENOG4105EC3 peptidase S51, dipeptidase E MLA2C4_09025 ENOG4107QIV Cytochrome c biogenesis protein MLA2C4_09050 ENOG4106BRA Membrane MLA2C4_09090 ENOG4105CJ1 ABC, transporter MLA2C4_09135 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) MLA2C4_09145 ENOG4108IJ0 Aspartate ammonia-lyase MLA2C4_09150 ENOG4105C6K Malic enzyme MLA2C4_09165 ENOG4105C0D helicase MLA2C4_09220 ENOG4105FVX MLA2C4_09270 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component MLA2C4_09275 ENOG4105DRS transport system, permease MLA2C4_09285 ENOG4108X79 transcriptional regulator MLA2C4_09290 ENOG4105E70 isomerase MLA2C4_09295 ENOG4105CE4 GlcNAc 6-P deacetylase MLA2C4_09300 ENOG4105D2N Aldolase MLA2C4_09305 ENOG4105DE4 1-phosphofructokinase MLA2C4_09310 ENOG4105DKQ ROK family MLA2C4_09315 ENOG4105CSR polyphosphate kinase 2 MLA2C4_09325 ENOG4105DXI Major Facilitator superfamily MLA2C4_09340 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) MLA2C4_09350 ENOG4105EU0 Major facilitator Superfamily MLA2C4_09355 ENOG4105C6T cysteine synthase MLA2C4_09375 ENOG4105C8J )-transporter MLA2C4_09385 ENOG4105D7V transposase MLA2C4_09390 ENOG4105H67 Protein of unknown function (DUF421) MLA2C4_09410 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) MLA2C4_09415 ENOG4107R16 Multicopper oxidase MLA2C4_09425 ENOG4105BZU Histidine kinase MLA2C4_09430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MLA2C4_09435 ENOG4105CHR reductase MLA2C4_09440 ENOG4105CM2 brancheD-chain amino acid aminotransferase MLA2C4_09445 ENOG4105C7K acetolactate synthase MLA2C4_09455 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase MLA2C4_09465 ENOG4105C7B Threonine dehydratase MLA2C4_09490 ENOG4105C6X Major Facilitator MLA2C4_09495 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b MLA2C4_09510 ENOG4105DY9 regulatoR MLA2C4_09515 ENOG4105CYC Transferase MLA2C4_09535 ENOG4105F6J Alpha beta hydrolase fold MLA2C4_09550 ENOG41068WN MLA2C4_09570 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) MLA2C4_09585 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) MLA2C4_09590 ENOG4105C0X amino acid MLA2C4_09615 ENOG4107RHR regulatoR MLA2C4_09625 ENOG4105D9N nucleoside MLA2C4_09630 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) MLA2C4_09655 ENOG4107RAQ aminopeptidase MLA2C4_09660 ENOG4107R16 Multicopper oxidase MLA2C4_09720 ENOG4108T5E Copper resistance protein MLA2C4_09725 ENOG4105KTB nuclear export factor GLE1 MLA2C4_09730 ENOG4107RT3 EamA-like transporter family MLA2C4_09735 ENOG4105GZI Transcriptional regulator MLA2C4_09740 ENOG4108Z40 Transcriptional regulator MLA2C4_09745 ENOG4107ZXU DSBA oxidoreductase MLA2C4_09750 ENOG4108TVJ Nitroreductase MLA2C4_09765 ENOG4106F5Q Membrane MLA2C4_09770 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) MLA2C4_09780 ENOG4105CKI cobalamin synthesis protein MLA2C4_09795 ENOG4108Z7G MaoC domain protein dehydratase MLA2C4_09800 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) MLA2C4_09815 ENOG4105C0Z ABC transporter MLA2C4_09820 ENOG4108IV0 ABC, transporter MLA2C4_09825 ENOG4105C32 Amino acid ABC transporter (Permease) MLA2C4_09835 ENOG4105SKE transcriptional Regulator LysR family MLA2C4_09845 ENOG4105MDS 4-oxalocrotonate tautomerase MLA2C4_09865 ENOG4105C4M (Ubiquinol oxidase) subunit I MLA2C4_09870 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii MLA2C4_09875 ENOG4108JJ9 ABC, transporter MLA2C4_09880 ENOG4108JJ8 (ABC) transporter MLA2C4_09885 ENOG4105K64 Glycosyl transferase, family 2 MLA2C4_09900 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A MLA2C4_09930 ENOG4105BZ1 (ABC) transporter MLA2C4_09935 ENOG4105EFI regulatoR MLA2C4_09940 ENOG4105BZU Histidine kinase MLA2C4_09950 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MLA2C4_09980 ENOG4108VQJ O-methyltransferase MLA2C4_09985 ENOG41075D4 Aminoglycoside 6-adenylyltransferase MLA2C4_09990 ENOG4108ZJ4 polysaccharide deacetylase MLA2C4_10000 ENOG41081VB Hydrolase MLA2C4_10010 ENOG4105D6E homoserine dehydrogenase MLA2C4_10035 ENOG4108KGH TRANSCRIPTIONal MLA2C4_10045 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MLA2C4_10050 ENOG4105BZU Histidine kinase MLA2C4_10055 ENOG4107VMI polysaccharide deacetylase MLA2C4_10065 ENOG4105KT7 mgtC SapB transporter MLA2C4_10070 ENOG4105VRR gCN5-related N-acetyltransferase MLA2C4_10080 ENOG4105DUU IucA IucC family protein MLA2C4_10085 ENOG4105CEY Amp-dependent synthetase and ligase MLA2C4_10105 ENOG4108WBH protein TIM barrel MLA2C4_10110 ENOG4105YWU small acid-soluble spore protein MLA2C4_10120 ENOG4108ZUB Lysine exporter protein (Lyse ygga) MLA2C4_10125 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MLA2C4_10175 ENOG4105KRN Transcriptional regulator, abrb family MLA2C4_10185 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase MLA2C4_10190 ENOG4105YVS arsR family transcriptional regulator MLA2C4_10195 ENOG4105CPC Aldo Keto reductase MLA2C4_10200 ENOG4107XZQ multidrug resistance protein MLA2C4_10230 ENOG4105C8Q Methyl-accepting chemotaxis MLA2C4_10245 ENOG4108K88 Membrane MLA2C4_10250 ENOG4108WPJ Ferritin-like domain MLA2C4_10265 ENOG4105DEN Luciferase family MLA2C4_10285 ENOG4105VMI -acetyltransferase MLA2C4_10290 ENOG4107QM2 Aldo Keto reductase MLA2C4_10295 ENOG4105CKI cobalamin synthesis protein MLA2C4_10305 ENOG4105DSE periplasmic solute binding protein MLA2C4_10310 ENOG4105K4T epimerase MLA2C4_10320 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) MLA2C4_10345 ENOG4107TB6 phosphoglycerate mutase MLA2C4_10365 ENOG4107T5V SNARE associated Golgi MLA2C4_10380 ENOG4108PJD permease MLA2C4_10390 ENOG4108S4H thioesterase Superfamily protein MLA2C4_10400 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) MLA2C4_10425 ENOG4105SXS Protein of unknown function (DUF456) MLA2C4_10430 ENOG4105C37 (CBS) domain MLA2C4_10450 ENOG4108Z7R Chaperone CsaA MLA2C4_10470 ENOG4108ZRV stage ii sporulation protein p MLA2C4_10480 ENOG4108VXD carboxy-peptidase MLA2C4_10485 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) MLA2C4_10495 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) MLA2C4_10555 ENOG4108X4Q Hydrolase MLA2C4_10565 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) MLA2C4_10570 ENOG4107UWY Methyltransferase MLA2C4_10585 ENOG41087PP glycosyltransferase MGT family MLA2C4_10590 ENOG4108JYZ YitT family MLA2C4_10595 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MLA2C4_10625 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MLA2C4_10690 ENOG4105KBJ sporulation protein ytfj MLA2C4_10715 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MLA2C4_10735 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) MLA2C4_10740 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MLA2C4_10750 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein MLA2C4_10755 ENOG4105EMN RNA polymerase sigma factor MLA2C4_10780 ENOG4105CNW domain protein MLA2C4_10790 ENOG4108V06 Glutathione peroxidase MLA2C4_10805 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MLA2C4_10810 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) MLA2C4_10845 ENOG4105MCT stage V sporulation protein S MLA2C4_10850 ENOG4107T65 Integrase MLA2C4_10855 ENOG410635T phage-like element pbsx protein MLA2C4_10945 ENOG4105C5H ABC transporter MLA2C4_10960 ENOG4108UUM single-stranded DNA-binding protein MLA2C4_10980 ENOG4107YX5 Pfam:DUF548 MLA2C4_10985 ENOG4105C75 arginyL-tRNA synthetase MLA2C4_11015 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) MLA2C4_11020 ENOG4105C5S asparaginyl-tRNA synthetase MLA2C4_11040 ENOG4105EC2 ftsk spoIIIe MLA2C4_11090 ENOG4105C8J )-transporter MLA2C4_11105 ENOG4107XGZ Hydrolase MLA2C4_11110 ENOG4105CY2 Citrate transporter MLA2C4_11115 ENOG4105C0A alcohol dehydrogenase MLA2C4_11130 ENOG4105KD7 acetyltransferase MLA2C4_11135 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase MLA2C4_11160 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 MLA2C4_11185 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) MLA2C4_11205 ENOG4107RVG penicillin-binding protein MLA2C4_11215 ENOG4105E9Q Acyl-transferase MLA2C4_11220 ENOG4108UT2 hemolysin iii MLA2C4_11230 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) MLA2C4_11240 ENOG4108RCR degv family MLA2C4_11250 ENOG4108KF3 Electron transport protein SCO1 SenC MLA2C4_11255 ENOG4107Y70 Heat shock protein MLA2C4_11260 ENOG4105CAQ asparagine synthetase MLA2C4_11280 ENOG4108MES Periplasmic binding protein MLA2C4_11285 ENOG4105F0I Aminotransferase MLA2C4_11310 ENOG4105D8X mechanosensitive ion channel MLA2C4_11315 ENOG4105BZU Histidine kinase MLA2C4_11320 ENOG4105WH1 Two component transcriptional regulator luxr family MLA2C4_11325 ENOG4106KNT transcriptional regulator MLA2C4_11355 ENOG4105CMG Carbohydrate kinase MLA2C4_11360 ENOG4105C6Z Gluconate MLA2C4_11400 ENOG4108IJ8 ABC transporter MLA2C4_11405 ENOG4105E90 ABC transporter MLA2C4_11440 ENOG4105C37 (CBS) domain MLA2C4_11465 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MLA2C4_11480 ENOG4107S4Y M20 DapE family protein YgeY MLA2C4_11485 ENOG4108TSC N-acetyltransferase MLA2C4_11490 ENOG4108JUB Transcriptional regulator MLA2C4_11495 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein MLA2C4_11535 ENOG4108N23 SpoOM-related protein MLA2C4_11540 ENOG410841Q phosphoesterase PA-phosphatase related protein MLA2C4_11550 ENOG4105SZ6 Thioredoxin MLA2C4_11555 ENOG4105VTR Integrase MLA2C4_11650 ENOG4108SXZ UPF0302 protein MLA2C4_11655 ENOG4105KRN Transcriptional regulator, abrb family MLA2C4_11700 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MLA2C4_11770 ENOG4108TFU terminase (Small subunit) MLA2C4_11775 ENOG4105IG6 Phage terminase, large subunit MLA2C4_12030 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) MLA2C4_12035 ENOG4105D7V transposase MLA2C4_12090 ENOG4105BZ4 penicillin-binding protein MLA2C4_12100 ENOG4105CZM Major Facilitator MLA2C4_12115 ENOG4105DXD 2-methylcitrate dehydratase MLA2C4_12120 ENOG4105CR4 methylisocitrate lyase MLA2C4_12125 ENOG4105C1G acyl-Coa dehydrogenase MLA2C4_12130 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase MLA2C4_12140 ENOG4105N14 lysine exporter protein LysE YggA MLA2C4_12145 ENOG4105E39 Enoyl-CoA hydratase MLA2C4_12160 ENOG4107RFY SbcCD D subunit MLA2C4_12185 ENOG4105FCD Major Facilitator MLA2C4_12190 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase MLA2C4_12195 ENOG4105E4F Isochorismate synthase MLA2C4_12200 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase MLA2C4_12205 ENOG4105WQI isochorismatase MLA2C4_12210 ENOG4105CEY Amp-dependent synthetase and ligase MLA2C4_12215 ENOG4105WQT MbtH domain protein MLA2C4_12220 ENOG4105C0R drug resistance transporter emrb qaca subfamily MLA2C4_12235 ENOG4105K70 DNA-binding protein MLA2C4_12250 ENOG4105BZG amino acid carrier protein MLA2C4_12270 ENOG4105FE9 pseudouridine synthase MLA2C4_12275 ENOG4105C22 threonyL-tRNA synthetase MLA2C4_12280 ENOG4105C19 ABC transporter MLA2C4_12290 ENOG4107SKW Inherit from COG: Alpha beta hydrolase MLA2C4_12330 ENOG4108D32 Methyltransferase MLA2C4_12350 ENOG41081I9 integral membrane protein MLA2C4_12360 ENOG4108Y4K DNA-binding transcriptional activator MLA2C4_12375 ENOG4107MII Sugar-specific transcriptional regulator TrmB MLA2C4_12390 ENOG4105EYF MMPL domain protein MLA2C4_12410 ENOG4105WCN acetyltransferase MLA2C4_12440 ENOG4105C1Q protoporphyrinogen oxidase MLA2C4_12450 ENOG41068WN MLA2C4_12460 ENOG4105VEQ Cold shock protein MLA2C4_12485 ENOG4107V2S Transcriptional regulator MLA2C4_12490 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) MLA2C4_12505 ENOG4105DND Transcriptional regulator MLA2C4_12510 ENOG4108RPX mosc domain containing protein MLA2C4_12520 ENOG4105BZ1 (ABC) transporter MLA2C4_12525 ENOG4105BZ1 (ABC) transporter MLA2C4_12560 ENOG4108VP3 Lysine exporter protein (LysE YggA) MLA2C4_12565 ENOG4108JCI Transcriptional regulator MLA2C4_12600 ENOG4105XSJ toxin secretion phage lysis holin MLA2C4_12620 ENOG4108IBT Inherit from COG: transposase MLA2C4_12655 ENOG4105VZ8 Transcriptional regulator MLA2C4_12715 ENOG4105EWK phytoene MLA2C4_12720 ENOG4108KPJ rna polymerase sigma factor MLA2C4_12740 ENOG4105F32 YngK protein MLA2C4_12760 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) MLA2C4_12765 ENOG4105RD7 BadF BadG BcrA BcrD MLA2C4_12775 ENOG4107STF Involved in phosphonate degradation (By similarity) MLA2C4_12780 ENOG4105C7B Threonine dehydratase MLA2C4_12785 ENOG4108INS Transcriptional regulator MLA2C4_12875 ENOG4105C2M dna polymerase I MLA2C4_12905 ENOG4105KNA -acetyltransferase MLA2C4_12940 ENOG4105KRN Transcriptional regulator, abrb family MLA2C4_12955 ENOG4107QPV Serine Threonine protein kinase MLA2C4_12970 ENOG4108C33 Resolvase MLA2C4_13100 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase MLA2C4_13115 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) MLA2C4_13185 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) MLA2C4_13200 ENOG4105C1J atp-dependent rna helicase MLA2C4_13230 ENOG4108RZE Tetr family transcriptional regulator MLA2C4_13250 ENOG41088CC tellurite resistance protein tehB MLA2C4_13260 ENOG4107RA9 decarboxylase MLA2C4_13265 ENOG4105K56 Transcriptional regulator MLA2C4_13295 ENOG4105CIN aminoacyl-histidine dipeptidase MLA2C4_13330 ENOG4107RVG penicillin-binding protein MLA2C4_13335 ENOG4105EMN RNA polymerase sigma factor MLA2C4_13345 ENOG4107RF6 penicillin-binding protein MLA2C4_13350 ENOG4107RF6 penicillin-binding protein MLA2C4_13370 ENOG4105TRI Hydrolase MLA2C4_13400 ENOG4108B31 Spore germination protein MLA2C4_13415 ENOG4105CEP NADH dehydrogenase MLA2C4_13435 ENOG4105CJ1 ABC, transporter MLA2C4_13445 ENOG4107Z3H Transcriptional regulator, TetR family MLA2C4_13460 ENOG4105C1G acyl-Coa dehydrogenase MLA2C4_13465 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase MLA2C4_13470 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit MLA2C4_13475 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase MLA2C4_13480 ENOG4105E39 Enoyl-CoA hydratase MLA2C4_13485 ENOG4107QX3 carboxylase MLA2C4_13490 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MLA2C4_13505 ENOG4105DBI uridine monophosphokinase MLA2C4_13535 ENOG4105T9C HD domain MLA2C4_13545 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) MLA2C4_13570 ENOG41075H3 AraC family transcriptional regulator MLA2C4_13600 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) MLA2C4_13615 ENOG4108A04 Beta-lactamase MLA2C4_13650 ENOG4108V4B ThiJ pfpI MLA2C4_13665 ENOG4107Y80 Major Facilitator superfamily MLA2C4_13670 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase MLA2C4_13680 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr MLA2C4_13685 ENOG4105KVH Transcriptional regulator MLA2C4_13725 ENOG4108DMH HTH_ARAC MLA2C4_13735 ENOG4105SX7 Transporter MLA2C4_13760 ENOG4105CPQ Dehydrogenase MLA2C4_13765 ENOG410900G Protein of unknown function (DUF421) MLA2C4_13775 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) MLA2C4_13795 ENOG4105DK7 lysyl-tRNA synthetase MLA2C4_13825 ENOG4106NZI LysR family Transcriptional regulator MLA2C4_13830 ENOG4105CPC Aldo Keto reductase MLA2C4_13875 ENOG4105D6E homoserine dehydrogenase MLA2C4_13890 ENOG4105ETU transcriptional activator (TenA MLA2C4_13940 ENOG4105XSJ toxin secretion phage lysis holin MLA2C4_14060 ENOG4105D7V transposase MLA2C4_14070 ENOG410667J hydrolase MLA2C4_14075 ENOG4105BZU Histidine kinase MLA2C4_14080 ENOG4107RF6 penicillin-binding protein MLA2C4_14115 ENOG4108HGU Histidine kinase MLA2C4_14125 ENOG4105RHY Pfam:UPF0157 MLA2C4_14130 ENOG4105CB2 alcohol dehydrogenase MLA2C4_14135 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase MLA2C4_14140 ENOG4105CJN penicillin-binding protein MLA2C4_14180 ENOG4107TXC Transcriptional regulator MLA2C4_14185 ENOG4107SFI Major Facilitator superfamily MLA2C4_14190 ENOG4108Z5V transcriptional regulator, merr family MLA2C4_14230 ENOG4107Y9U Membrane MLA2C4_14260 ENOG4105FCD Major Facilitator MLA2C4_14280 ENOG4105E09 nadh pyrophosphatase MLA2C4_14285 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) MLA2C4_14290 ENOG4108Z4K mutator MutT protein MLA2C4_14310 ENOG4108XI2 Domain of unknown function (DUF1963) MLA2C4_14330 ENOG4108NRW Phospholipase, patatin family MLA2C4_14335 ENOG4105KWG Pfam:DUF1696 MLA2C4_14370 ENOG4105PKS Excinuclease abc c subunit domain protein MLA2C4_14405 ENOG4107VFR oxidoreductase MLA2C4_14430 ENOG4105U0R haloacid dehalogenase-like hydrolase MLA2C4_14435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MLA2C4_14440 ENOG4105BZU Histidine kinase MLA2C4_14475 ENOG4107WD8 ABC transporter, permease MLA2C4_14490 ENOG4108IUM Glycogen debranching enzyme MLA2C4_14515 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) MLA2C4_14525 ENOG4105FDR Membrane MLA2C4_14535 ENOG4105CIS alcohol dehydrogenase MLA2C4_14585 ENOG4105MSI germination protein ypeb MLA2C4_14620 ENOG4107Z3H Transcriptional regulator, TetR family MLA2C4_14650 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family MLA2C4_14660 ENOG4108MK9 spermidine N(1)-acetyltransferase MLA2C4_14665 ENOG4105E98 transcriptional regulator DeoR family MLA2C4_14690 ENOG4107QKR Dehydrogenase MLA2C4_14700 ENOG4107RUY (E1 component), alpha subunit MLA2C4_14710 ENOG4105E1F short-chain dehydrogenase reductase MLA2C4_14715 ENOG4105RHY Pfam:UPF0157 MLA2C4_14725 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) MLA2C4_14755 ENOG4107SQ8 Glycine betaine MLA2C4_14760 ENOG4108IJ7 Glycine betaine MLA2C4_14790 ENOG41082BV acetyltransferase MLA2C4_14795 ENOG4108M1A Chitin-binding protein MLA2C4_14800 ENOG41087PP glycosyltransferase MGT family MLA2C4_14820 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MLA2C4_14825 ENOG4105MSB protein, conserved in bacteria MLA2C4_14830 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 MLA2C4_14880 ENOG4105EEM helicase MLA2C4_14895 ENOG4105C9U ATP-dependent DNA helicase RecQ MLA2C4_14945 ENOG4108M1A Chitin-binding protein MLA2C4_14970 ENOG4105BZG amino acid carrier protein MLA2C4_14975 ENOG4105C26 Dehydrogenase MLA2C4_14980 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) MLA2C4_14985 ENOG4105CTU Proline racemase MLA2C4_14990 ENOG4105CTU Proline racemase MLA2C4_14995 ENOG41080HI glycine oxidase MLA2C4_15005 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein MLA2C4_15035 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) MLA2C4_15040 ENOG4107T5V SNARE associated Golgi MLA2C4_15050 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD MLA2C4_15080 ENOG4105DTQ mandelate racemase muconate lactonizing MLA2C4_15130 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) MLA2C4_15165 ENOG4105CUV Homoserine Kinase MLA2C4_15170 ENOG4105DPN Oligoendopeptidase f MLA2C4_15175 ENOG4105DVH amino acid MLA2C4_15185 ENOG4105EPR degv family MLA2C4_15260 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) MLA2C4_15265 ENOG4106K7D Major facilitator family transporter MLA2C4_15285 ENOG4107BMA Transglycosylase associated protein MLA2C4_15300 ENOG41089UC methyltransferase, type 11 MLA2C4_15340 ENOG4105CHM Aminotransferase MLA2C4_15355 ENOG4108ZMI UPF0477 protein MLA2C4_15370 ENOG4105DVE abc transporter atp-binding protein MLA2C4_15415 ENOG4105C02 permease MLA2C4_15425 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) MLA2C4_15430 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component MLA2C4_15435 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein MLA2C4_15450 ENOG4105E09 nadh pyrophosphatase MLA2C4_15470 ENOG4108AQF aminoglycoside N(3)-acetyltransferase MLA2C4_15500 ENOG4105I4A GCN5-related N-acetyltransferase MLA2C4_15525 ENOG4108ZCF integral membrane protein MLA2C4_15535 ENOG4105C5H ABC transporter MLA2C4_15540 ENOG4105EYF MMPL domain protein MLA2C4_15570 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase MLA2C4_15625 ENOG4105CY2 Citrate transporter MLA2C4_15630 ENOG4105E39 Enoyl-CoA hydratase MLA2C4_15635 ENOG4105J5T Amp-dependent synthetase and ligase MLA2C4_15640 ENOG4108JUB Transcriptional regulator MLA2C4_15655 ENOG4105D4B ABC, transporter MLA2C4_15660 ENOG4105F5R ABC transporter MLA2C4_15665 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane MLA2C4_15675 ENOG4105DKT Transcriptional regulator MLA2C4_15680 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) MLA2C4_15690 ENOG41061GT Aldolase MLA2C4_15715 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) MLA2C4_15745 ENOG4105II7 pyrroline-5-carboxylate reductase MLA2C4_15755 ENOG4107258 Transcriptional regulator MLA2C4_15775 ENOG4105E0Y RtcB Protein MLA2C4_15780 ENOG4105ECK Fatty Acid Desaturase MLA2C4_15790 ENOG4105G6Z alkaline phosphatase MLA2C4_15800 ENOG4105VMP Transcriptional regulator MLA2C4_15815 ENOG41090T1 Membrane MLA2C4_15825 ENOG4108WCX response regulator MLA2C4_15840 ENOG41068WN MLA2C4_15865 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MLA2C4_15885 ENOG4105C8Y Acetylornithine aminotransferase MLA2C4_15925 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MLA2C4_15940 ENOG4108TVJ Nitroreductase MLA2C4_15945 ENOG4105FS7 Transcriptional regulator MLA2C4_15985 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family MLA2C4_15995 ENOG4105CMR udp-glucose 4-epimerase MLA2C4_16015 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) MLA2C4_16020 ENOG4108XET gCN5-related N-acetyltransferase MLA2C4_16065 ENOG4105RHY Pfam:UPF0157 MLA2C4_16090 ENOG410635A Membrane MLA2C4_16100 ENOG4108IQI permease MLA2C4_16110 ENOG4105F1N DNA alkylation repair MLA2C4_16125 ENOG4107ZY0 Phenazine biosynthesis-like protein MLA2C4_16145 ENOG4107RF6 penicillin-binding protein MLA2C4_16150 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) MLA2C4_16185 ENOG4105P4J Allophanate hydrolase, subunit 1 MLA2C4_16190 ENOG4107258 Transcriptional regulator MLA2C4_16200 ENOG4106N3A copper homeostasis protein cutc MLA2C4_16205 ENOG4108ZRV stage ii sporulation protein p MLA2C4_16210 ENOG4108ZHR arsR family transcriptional regulator MLA2C4_16225 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) MLA2C4_16230 ENOG4105C0R drug resistance transporter emrb qaca subfamily MLA2C4_16235 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MLA2C4_16245 ENOG4105RXJ MLA2C4_16250 ENOG4105FDT acyl-CoA dehydrogenase MLA2C4_16265 ENOG4105DWD nucleoside recognition domain protein MLA2C4_16305 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) MLA2C4_16310 ENOG41087PP glycosyltransferase MGT family MLA2C4_16335 ENOG4105E2A Dehydrogenase MLA2C4_16345 ENOG4108IJ0 Aspartate ammonia-lyase MLA2C4_16350 ENOG4105HDK L-asparaginase MLA2C4_16355 ENOG4108IMY Transcriptional regulator MLA2C4_16365 ENOG4105BZU Histidine kinase MLA2C4_16390 ENOG41075H3 AraC family transcriptional regulator MLA2C4_16400 ENOG4105YWU small acid-soluble spore protein MLA2C4_16405 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) MLA2C4_16410 ENOG4105CUB amino acid MLA2C4_16415 ENOG4105II7 pyrroline-5-carboxylate reductase MLA2C4_16420 ENOG4108NHD germination protein MLA2C4_16425 ENOG4108Q8B Spore germination protein MLA2C4_16450 ENOG4105CSV Glutaminase MLA2C4_16485 ENOG4105CGH 5'-nucleotidase MLA2C4_16495 ENOG4105CHJ isochorismatase hydrolase MLA2C4_16620 ENOG4108606 TspO/MBR family MLA2C4_16625 ENOG4105CVP deoxyribo-dipyrimidine photolyase MLA2C4_16640 ENOG4105F2M alpha beta hydrolase fold-3 domain protein MLA2C4_16655 ENOG4108TWJ NADH dehydrogenase subunit 5 MLA2C4_16660 ENOG4105GPN Uncharacterized conserved protein (DUF2294) MLA2C4_16685 ENOG4108VJ1 Transcriptional regulator (CarD family MLA2C4_16715 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase MLA2C4_16725 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) MLA2C4_16765 ENOG4105D6J arsenicaL-resistance protein MLA2C4_16770 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase MLA2C4_16775 ENOG41085FC arsR family transcriptional regulator MLA2C4_16795 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) MLA2C4_16805 ENOG4107P5I polyketide synthase MLA2C4_16810 ENOG4108IG5 Transcriptional regulator MLA2C4_16855 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) MLA2C4_16860 ENOG4105C0R drug resistance transporter emrb qaca subfamily MLA2C4_16915 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MLA2C4_16920 ENOG41062D9 Histidine kinase MLA2C4_16950 ENOG4105K6H D-cysteine desulfhydrase MLA2C4_16975 ENOG4105VZ8 Transcriptional regulator MLA2C4_16995 ENOG4105JQZ Methyltransferase MLA2C4_17010 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) MLA2C4_17015 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) MLA2C4_17035 ENOG4105BZU Histidine kinase MLA2C4_17045 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) MLA2C4_17050 ENOG4105DJB Major Facilitator Superfamily MLA2C4_17055 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) MLA2C4_17060 ENOG4107QR9 Iron-sulfur cluster binding protein MLA2C4_17070 ENOG4106P55 Transcriptional regulator MLA2C4_17090 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A MLA2C4_17110 ENOG4108JQ1 Dehydrogenase MLA2C4_17140 ENOG4105YWU small acid-soluble spore protein MLA2C4_17180 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase MLA2C4_17185 ENOG4108IG5 Transcriptional regulator MLA2C4_17230 ENOG4108ISG Major Facilitator MLA2C4_17245 ENOG4107MII Sugar-specific transcriptional regulator TrmB MLA2C4_17250 ENOG4105CZM Major Facilitator MLA2C4_17265 ENOG4105DA5 (ABC) transporter MLA2C4_17270 ENOG41069JR MLA2C4_17290 ENOG4105CRW Short chain fatty acid transporter MLA2C4_17300 ENOG4105DYS nad(p)h dehydrogenase (quinone) MLA2C4_17335 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) MLA2C4_17365 ENOG4105EQ0 Major Facilitator superfamily MLA2C4_17370 ENOG4108IND Tetr family transcriptional regulator MLA2C4_17375 ENOG4107SWG transcriptional regulator MERR family MLA2C4_17400 ENOG4108Z66 YbaK ebsC protein MLA2C4_17415 ENOG4105D7V transposase MLA2C4_17440 ENOG4105C5Q Transcriptional regulator MLA2C4_17460 ENOG4108PSK reductase MLA2C4_17525 ENOG4105E09 nadh pyrophosphatase MLA2C4_17530 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase MLA2C4_17535 ENOG4105DKQ ROK family MLA2C4_17550 ENOG4108UW5 maltose o-acetyltransferase MLA2C4_17560 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) MLA2C4_17565 ENOG4105C31 Tryptophanyl-tRNA synthetase MLA2C4_17575 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MLA2C4_17580 ENOG41089BK Glutamine amido-transferase MLA2C4_17605 ENOG4108R96 Methyltransferase, YaeB family MLA2C4_17610 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) MLA2C4_17620 ENOG4105EV4 Multidrug resistance protein mdtH MLA2C4_17655 ENOG4105C37 (CBS) domain MLA2C4_17670 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase MLA2C4_17675 ENOG4105FAW cDP-glucose 4,6-dehydratase MLA2C4_17700 ENOG4105DDN Pentapeptide repeat-containing protein MLA2C4_17705 ENOG4105XDF Protein of unknown function (DUF1272) MLA2C4_17710 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) MLA2C4_17715 ENOG4105CMG Carbohydrate kinase MLA2C4_17720 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) MLA2C4_17730 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase MLA2C4_17745 ENOG4105C44 Serine transporter MLA2C4_17800 ENOG4105CHR reductase MLA2C4_17810 ENOG4105KNA -acetyltransferase MLA2C4_17820 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein MLA2C4_17825 ENOG4105KVH Transcriptional regulator MLA2C4_17910 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) MLA2C4_17955 ENOG4105H3G oxidoreductase MLA2C4_17990 ENOG4105CIS alcohol dehydrogenase MLA2C4_18015 ENOG4108TN2 lmbE family MLA2C4_18025 ENOG4107R3E Citrate transporter MLA2C4_18040 ENOG4105DA5 (ABC) transporter MLA2C4_18055 ENOG4108MES Periplasmic binding protein MLA2C4_18060 ENOG4105EHG Permease protein MLA2C4_18065 ENOG4105DQ5 transport system permease protein MLA2C4_18070 ENOG4105NX3 Membrane MLA2C4_18090 ENOG41068WN MLA2C4_18095 ENOG4107CUJ Protein of unknown function (DUF2690) MLA2C4_18105 ENOG4107V2S Transcriptional regulator MLA2C4_18125 ENOG4105C98 muts2 protein MLA2C4_18140 ENOG4105E5K Alpha-amylase MLA2C4_18145 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase MLA2C4_18150 ENOG4105DPN Oligoendopeptidase f MLA2C4_18155 ENOG4108A04 Beta-lactamase MLA2C4_18170 ENOG4105EGI Transcriptional regulator MLA2C4_18185 ENOG4107VXM glycerophosphoryl diester phosphodiesterase MLA2C4_18195 ENOG41082BM Transcriptional regulator, arsr family MLA2C4_18200 ENOG4105CIS alcohol dehydrogenase MLA2C4_18235 ENOG4105C09 Bile acid MLA2C4_18240 ENOG4105CQB FAD linked oxidase domain protein MLA2C4_18255 ENOG4105BZU Histidine kinase MLA2C4_18265 ENOG41067SE Tetr family transcriptional regulator MLA2C4_18270 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity MLA2C4_18300 ENOG4105KT7 mgtC SapB transporter MLA2C4_18320 ENOG4105D06 uba thif-type nad fad binding protein MLA2C4_18330 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase MLA2C4_18335 ENOG4105EAB amino acid AbC transporter MLA2C4_18345 ENOG4108HW4 amino acid AbC transporter MLA2C4_18350 ENOG41073R8 VanW family MLA2C4_18360 ENOG4108R1P MLA2C4_18375 ENOG4105VEQ Cold shock protein MLA2C4_18395 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) MLA2C4_18415 ENOG410904N short-chain dehydrogenase reductase MLA2C4_18425 ENOG4106IQC argininosuccinate lyase MLA2C4_18440 ENOG4108IA2 Sodium pantothenate symporter MLA2C4_18450 ENOG4105C26 Dehydrogenase MLA2C4_18455 ENOG4105CHR reductase MLA2C4_18465 ENOG4105EWU Squalene--hopene cyclase MLA2C4_18475 ENOG4105FR1 rard protein MLA2C4_18480 ENOG410696E Membrane MLA2C4_18495 ENOG4105D1F ATP-binding protein MLA2C4_18505 ENOG4108ZAF Molybdopterin MLA2C4_18510 ENOG4105CVM Molybdenum cofactor synthesis domain protein MLA2C4_18515 ENOG4105D06 uba thif-type nad fad binding protein MLA2C4_18520 ENOG4105TMB Formate nitrite transporter MLA2C4_18530 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) MLA2C4_18535 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) MLA2C4_18545 ENOG4108JB9 formate dehydrogenase MLA2C4_18595 ENOG4105CUZ uba thif-type nad fad binding protein MLA2C4_18610 ENOG4107QJT sodium dicarboxylate symporter MLA2C4_18615 ENOG4108KGH TRANSCRIPTIONal MLA2C4_18625 ENOG4105EMN RNA polymerase sigma factor MLA2C4_18640 ENOG4105CIG ABC transporter MLA2C4_18660 ENOG4108FPN Integrase MLA2C4_18665 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MLA2C4_18670 ENOG4105ZX1 Transposase C MLA2C4_18675 ENOG4105D9R oxidoreductase MLA2C4_18685 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MLA2C4_18690 ENOG4105K4P CoA-binding domain protein MLA2C4_18695 ENOG4105C0H protease MLA2C4_18700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MLA2C4_18705 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) MLA2C4_18710 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase MLA2C4_18720 ENOG4105W8X HesB YadR YfhF-family protein MLA2C4_18750 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) MLA2C4_18790 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MLA2C4_18800 ENOG4108JJA ABC, transporter MLA2C4_18805 ENOG4108I0Z Aconitate hydratase MLA2C4_18835 ENOG4105E5W Transporter MLA2C4_18845 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) MLA2C4_18865 ENOG4107F3J Amp-dependent synthetase and ligase MLA2C4_18870 ENOG4107ZYJ bioY protein MLA2C4_18875 ENOG4105CEY Amp-dependent synthetase and ligase MLA2C4_18915 ENOG4107AYK membrAne MLA2C4_18925 ENOG4105BZU Histidine kinase MLA2C4_18930 ENOG4105FBA Phospholipase Carboxylesterase MLA2C4_18935 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase MLA2C4_18940 ENOG4105CK7 Sodium proline symporter MLA2C4_18945 ENOG4105CBC glutamate synthase MLA2C4_18950 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MLA2C4_18955 ENOG4108VJ1 Transcriptional regulator (CarD family MLA2C4_18960 ENOG4108903 Formimidoylglutamase MLA2C4_18985 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) MLA2C4_19025 ENOG4105EKQ RNA-directed DNA polymerase MLA2C4_19040 ENOG4107QIV Cytochrome c biogenesis protein MLA2C4_19065 ENOG4105CH2 amidohydrolase MLA2C4_19075 ENOG4105CJ1 ABC, transporter MLA2C4_19090 ENOG4107RSM transcriptional regulator MLA2C4_19100 ENOG41067MG lrgb family MLA2C4_19120 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase MLA2C4_19140 ENOG4105BZ1 (ABC) transporter MLA2C4_19145 ENOG4105BZ1 (ABC) transporter MLA2C4_19185 ENOG4108HW3 (ABC) transporter MLA2C4_19190 ENOG4105CGH 5'-nucleotidase MLA2C4_19200 ENOG4108SVB resolvase MLA2C4_19220 ENOG4105K7K Transcriptional regulator MLA2C4_19225 ENOG4105BZ1 (ABC) transporter MLA2C4_19255 ENOG4105CAQ asparagine synthetase MLA2C4_19260 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase MLA2C4_19270 ENOG4105CPF Cell wall formation (By similarity) MLA2C4_19275 ENOG4105D3Q Sugar transferase MLA2C4_19310 ENOG4108KMV Glycosyl transferase (Group 1 MLA2C4_19315 ENOG41068W6 Capsular polysaccharide biosynthesis protein MLA2C4_19320 ENOG4107SJB teichoic acid biosynthesis MLA2C4_19325 ENOG4108KMV Glycosyl transferase (Group 1 MLA2C4_19330 ENOG4108PQP glycosyl transferase group 1 MLA2C4_19340 ENOG4107YJ4 chain length determinant protein MLA2C4_19345 ENOG4105HTX biosynthesis protein MLA2C4_19350 ENOG4105C5F glutamine synthetase MLA2C4_19355 ENOG4105KV4 Transcriptional regulator MLA2C4_19360 ENOG4105CXI aluminum resistance protein MLA2C4_19365 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) MLA2C4_19370 ENOG4105EN6 Membrane MLA2C4_19375 ENOG4106F1P AAA ATPase, central domain protein MLA2C4_19405 ENOG41069ER domain protein MLA2C4_19410 ENOG4105DM4 PTS System MLA2C4_19415 ENOG4105DE4 1-phosphofructokinase MLA2C4_19420 ENOG4105E98 transcriptional regulator DeoR family MLA2C4_19425 ENOG4107QW4 alcohol dehydrogenase MLA2C4_19430 ENOG4108SJC Membrane MLA2C4_19440 ENOG4105C85 amino acid MLA2C4_19465 ENOG4105TMB Formate nitrite transporter MLA2C4_19470 ENOG4105K70 DNA-binding protein MLA2C4_19475 ENOG4108HYG acetyltransferase MLA2C4_19480 ENOG4105C59 p-type ATPase MLA2C4_19485 ENOG410681U heavy metal transport detoxification protein MLA2C4_19490 ENOG4105VPX protein, conserved in bacteria MLA2C4_19500 ENOG4105NIV Esterase MLA2C4_19505 ENOG4105E0A ABC, transporter MLA2C4_19530 ENOG4105CGK Exodeoxyribonuclease III MLA2C4_19540 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) MLA2C4_19545 ENOG4105D03 DNA-3-methyladenine glycosylase II MLA2C4_19575 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase MLA2C4_19580 ENOG4105BZU Histidine kinase MLA2C4_19595 ENOG4108DMA Nad-dependent epimerase dehydratase MLA2C4_19620 ENOG41067MG lrgb family MLA2C4_19640 ENOG4108S3Y transcriptional regulator MLA2C4_19645 ENOG4105CS2 ec 3.2.1.21 MLA2C4_19650 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C MLA2C4_19660 ENOG4105F0V Cell wall hydrolase MLA2C4_19675 ENOG4105E0M Sulfatase MLA2C4_19680 ENOG410890F Dynamin family MLA2C4_19695 ENOG4107QHE Choloylglycine hydrolase MLA2C4_19730 ENOG4105DQU oxidoreductase, subunit beta MLA2C4_19735 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein MLA2C4_19740 ENOG4108IGT Dipeptidase MLA2C4_19745 ENOG4105MCT stage V sporulation protein S MLA2C4_19750 ENOG4105D48 metallophosphoesterase MLA2C4_19780 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase MLA2C4_19795 ENOG4105XZV Protein of unknown function (DUF3243) MLA2C4_19800 ENOG4108RKS Short-chain dehydrogenase reductase Sdr MLA2C4_19820 ENOG4105UIB (ABC) transporter MLA2C4_19825 ENOG4108JQ9 ABC transporter MLA2C4_19830 ENOG4105DIH basic membrane MLA2C4_19835 ENOG4105FDP GntR family transcriptional regulator MLA2C4_19845 ENOG4107QZI cell division protein FtsK MLA2C4_19855 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit MLA2C4_19865 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) MLA2C4_19875 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) MLA2C4_19880 ENOG4108S0H Dipicolinic acid synthetase, b subunit MLA2C4_19885 ENOG4105E35 Dipicolinate synthase subunit A MLA2C4_19895 ENOG4105C1V Peptidase, M16 MLA2C4_19915 ENOG4105DTN riboflavin biosynthesis protein ribF MLA2C4_19930 ENOG4105W7A Protein of unknown function (DUF503) MLA2C4_19940 ENOG4105VHM ribosomal protein MLA2C4_19945 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination MLA2C4_19950 ENOG4105CHV Transcription elongation factor NusA MLA2C4_19960 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) MLA2C4_19970 ENOG4105DZP Membrane-associated zinc metalloprotease MLA2C4_19975 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) MLA2C4_19980 ENOG4105KNE Phosphatidate cytidylyltransferase MLA2C4_20025 ENOG4108HE4 integrase family MLA2C4_20035 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) MLA2C4_20040 ENOG4105C79 DNA protecting protein DprA MLA2C4_20045 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha MLA2C4_20060 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) MLA2C4_20085 ENOG4105VB6 UPF0109 protein MLA2C4_20105 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) MLA2C4_20110 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) MLA2C4_20125 ENOG4105CHR reductase MLA2C4_20130 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase MLA2C4_20145 ENOG4105CB5 ATP-dependent DNA helicase recG MLA2C4_20150 ENOG4105DP4 dak2 domain fusion protein ylov MLA2C4_20155 ENOG4108ZAA Alkaline-shock protein MLA2C4_20170 ENOG4105FJ0 thiamine MLA2C4_20175 ENOG4105DJV ribulose-phosphate 3-epimerase MLA2C4_20185 ENOG4105D9P serine threonine protein kinase MLA2C4_20190 ENOG4108ZF3 Phosphatase MLA2C4_20195 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MLA2C4_20200 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B MLA2C4_20215 ENOG4105C25 Primosomal protein n' MLA2C4_20220 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase MLA2C4_20240 ENOG4105DSJ YicC domain protein MLA2C4_20250 ENOG4105F23 Fibronectin-binding protein MLA2C4_20265 ENOG4105DC7 peptidase M24 MLA2C4_20310 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) MLA2C4_20345 ENOG4105C34 Pseudouridine synthase MLA2C4_20370 ENOG4105DBK s4 domain protein MLA2C4_20375 ENOG41067XK integral membrane protein MLA2C4_20385 ENOG4105DFA alanine racemase domain protein MLA2C4_20390 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase MLA2C4_20395 ENOG4105WR5 sporulation protein, YlmC YmxH family MLA2C4_20405 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MLA2C4_20415 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) MLA2C4_20420 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) MLA2C4_20425 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) MLA2C4_20435 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) MLA2C4_20440 ENOG4105CNI cell division protein FtsW MLA2C4_20455 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) MLA2C4_20460 ENOG4105CJN penicillin-binding protein MLA2C4_20465 ENOG4105CJN penicillin-binding protein MLA2C4_20470 ENOG41068DC Essential cell division protein (By similarity) MLA2C4_20505 ENOG4105KNH Nucleic acid-binding protein MLA2C4_20515 ENOG41063PX domain protein MLA2C4_20520 ENOG4105D78 K07001 NTE family protein MLA2C4_20525 ENOG4105H20 Sporulation integral membrane protein YlbJ MLA2C4_20535 ENOG4106H78 methyltransferase MLA2C4_20555 ENOG4107TB6 phosphoglycerate mutase MLA2C4_20570 ENOG4106UY4 Inherit from COG: Scp-like extracellular MLA2C4_20615 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) MLA2C4_20625 ENOG4105CNI cell division protein FtsW MLA2C4_20630 ENOG4105ZPI UPF0358 protein MLA2C4_20640 ENOG4108IAB Phoh family MLA2C4_20660 ENOG4105QA2 MLA2C4_20665 ENOG4105CI3 gtp-binding protein typa MLA2C4_20675 ENOG4105ECY inositol monophosphatase MLA2C4_20695 ENOG4105CXN decarboxylase MLA2C4_20735 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein MLA2C4_20755 ENOG4105CPP Dehydrogenase, E1 component MLA2C4_20770 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) MLA2C4_20775 ENOG4108X4Q Hydrolase MLA2C4_20790 ENOG4105CN5 Metallo-Beta-Lactamase MLA2C4_20795 ENOG4107ZYR domain protein MLA2C4_20830 ENOG4108XRC Protein of unknown function (DUF458) MLA2C4_20835 ENOG4107IN1 Protein of unknown function (DUF1797) MLA2C4_20850 ENOG4105EPM Diguanylate phosphodiesterase MLA2C4_20855 ENOG4105K6S Short-chain dehydrogenase reductase Sdr MLA2C4_20875 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) MLA2C4_20885 ENOG4105UIN MLA2C4_20905 ENOG4105D7V transposase MLA2C4_20950 ENOG4108HGU Histidine kinase MLA2C4_20960 ENOG4105CHM Aminotransferase MLA2C4_20965 ENOG4105FKQ transcriptional regulator MLA2C4_20970 ENOG4105EG2 ABC transporter, permease MLA2C4_20980 ENOG4107FKK extracellular solute-binding protein family 1 MLA2C4_20990 ENOG4105CG3 alpha amylase, catalytic region MLA2C4_21035 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) MLA2C4_21040 ENOG4105CHU acetyl-coa acetyltransferase MLA2C4_21075 ENOG4105K7K Transcriptional regulator MLA2C4_21080 ENOG4105DTD Dehydrogenase MLA2C4_21100 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase MLA2C4_21125 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) MLA2C4_21140 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase MLA2C4_21150 ENOG4105BZU Histidine kinase MLA2C4_21170 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) MLA2C4_21185 ENOG4105CID antiterminator MLA2C4_21195 ENOG4105FDP GntR family transcriptional regulator MLA2C4_21205 ENOG4105CE4 GlcNAc 6-P deacetylase MLA2C4_21210 ENOG4108EC8 DNA internalization-related competence protein ComEC MLA2C4_21250 ENOG4107ZE5 PPIases accelerate the folding of proteins MLA2C4_21255 ENOG4105PTM secreted protein MLA2C4_21260 ENOG4105J7I hydrolase MLA2C4_21270 ENOG4105G6R Stage v sporulation protein ae MLA2C4_21280 ENOG4105CZ3 stage V sporulation protein ad MLA2C4_21285 ENOG41090VF Stage v sporulation protein ac MLA2C4_21305 ENOG4105C8J )-transporter MLA2C4_21310 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MLA2C4_21320 ENOG41082AN stage II sporulation protein MLA2C4_21325 ENOG4105DZ1 carboxypeptidase MLA2C4_21335 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family MLA2C4_21340 ENOG4105DVE abc transporter atp-binding protein MLA2C4_21375 ENOG4105D7N magnesium and cobalt transport protein CorA MLA2C4_21400 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MLA2C4_21410 ENOG4105I3K Ferric uptake regulator, Fur family MLA2C4_21415 ENOG4105MZ9 stage II sporulation protein m MLA2C4_21440 ENOG4105CPC Aldo Keto reductase MLA2C4_21450 ENOG4105RHY Pfam:UPF0157 MLA2C4_21470 ENOG4107SKW Inherit from COG: Alpha beta hydrolase MLA2C4_21480 ENOG4105ETE Transcriptional regulator (LacI family MLA2C4_21485 ENOG4108YM7 Gcn5-related n-acetyltransferase MLA2C4_21510 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) MLA2C4_21515 ENOG4108R6K riboflavin synthase, subunit alpha MLA2C4_21540 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MLA2C4_21545 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MLA2C4_21560 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MLA2C4_21570 ENOG4105DFD Na H antiporter MLA2C4_21575 ENOG4105CGH 5'-nucleotidase MLA2C4_21630 ENOG4108IXY short-chain dehydrogenase reductase MLA2C4_21635 ENOG41069FQ Metallo-beta-lactamase superfamily MLA2C4_21640 ENOG4105II7 pyrroline-5-carboxylate reductase MLA2C4_21645 ENOG4105EJQ L-serine dehydratase MLA2C4_21670 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic MLA2C4_21680 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) MLA2C4_21690 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) MLA2C4_21695 ENOG4105D9U N-acetyltransferase MLA2C4_21705 ENOG4108VZI ErfK ybiS ycfS ynhG family protein MLA2C4_21710 ENOG4108QEG Membrane MLA2C4_21715 ENOG4105CDA abc transporter atp-binding protein MLA2C4_21720 ENOG4105E5Q amino acid AbC transporter MLA2C4_21725 ENOG4108HW3 (ABC) transporter MLA2C4_21735 ENOG4105G7B Protein of unknown function (DUF2992) MLA2C4_21745 ENOG4108QY0 Membrane MLA2C4_21755 ENOG4105C7S Dehydrogenase MLA2C4_21760 ENOG4105CPP Dehydrogenase, E1 component MLA2C4_21780 ENOG4107RDP Dehydrogenase MLA2C4_21795 ENOG4108JUB Transcriptional regulator MLA2C4_21805 ENOG4108QXE glycerophosphoryl diester phosphodiesterase MLA2C4_21820 ENOG4107QQR Sporulation MLA2C4_21830 ENOG4105S1Z Stage IV sporulation protein B MLA2C4_21835 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) MLA2C4_21845 ENOG4105DX0 Hemolysin A MLA2C4_21855 ENOG4105CTB Polyprenyl synthetase MLA2C4_21880 ENOG4108ZSR alkaline shock protein MLA2C4_21885 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase MLA2C4_21910 ENOG410644B Stage III sporulation protein af MLA2C4_21920 ENOG4105KQ4 Stage iii sporulation protein ad MLA2C4_21925 ENOG4108CQH stage III sporulation protein AC MLA2C4_21930 ENOG4105KR5 Stage iii sporulation protein MLA2C4_21935 ENOG4105CD2 stage iii sporulation protein aa MLA2C4_21960 ENOG4105DC7 peptidase M24 MLA2C4_21975 ENOG4105CBJ Metal-dependent enzyme MLA2C4_21985 ENOG4107YBY Hydrolase MLA2C4_22020 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) MLA2C4_22025 ENOG4105WZW rhodanese family MLA2C4_22050 ENOG41080TC multidrug resistance protein MLA2C4_22085 ENOG4105CJ1 ABC, transporter MLA2C4_22090 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family MLA2C4_22105 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor MLA2C4_22120 ENOG4105C0D helicase MLA2C4_22240 ENOG4105C3R Methionine synthase MLA2C4_22250 ENOG4105C28 cystathionine MLA2C4_22255 ENOG4105C28 cystathionine MLA2C4_22275 ENOG4105C5X domain protein MLA2C4_22295 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase MLA2C4_22310 ENOG4108UTW Plays a role in the regulation of phosphate uptake MLA2C4_22315 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) MLA2C4_22320 ENOG4105E2Z phosphate ABC transporter (Permease MLA2C4_22325 ENOG4105C8U phosphate abc transporter MLA2C4_22330 ENOG4105PWN phosphate abc transporter MLA2C4_22335 ENOG4107RF6 penicillin-binding protein MLA2C4_22345 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) MLA2C4_22370 ENOG4105N80 Ferric uptake regulator, Fur family MLA2C4_22380 ENOG4105FDK ABC transporter MLA2C4_22385 ENOG4108JYZ YitT family MLA2C4_22390 ENOG41069ZM Protein of unknown function (DUF2624) MLA2C4_22415 ENOG4105EGD dinuclear metal center protein, YbgI family MLA2C4_22430 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MLA2C4_22435 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) MLA2C4_22460 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) MLA2C4_22465 ENOG4105KG3 cytidine deaminase MLA2C4_22470 ENOG4107YR5 Diacylglycerol kinase MLA2C4_22480 ENOG4105CTJ Metal Dependent Phosphohydrolase MLA2C4_22485 ENOG4105C9A Phoh family MLA2C4_22495 ENOG41068P3 sporulation protein YqfC MLA2C4_22500 ENOG4105KTH gatB Yqey MLA2C4_22510 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) MLA2C4_22515 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) MLA2C4_22545 ENOG4105CSA Coproporphyrinogen iii oxidase MLA2C4_22550 ENOG4105KVH Transcriptional regulator MLA2C4_22575 ENOG4105TQK DNA polymerase iii, delta' subunit MLA2C4_22585 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 MLA2C4_22590 ENOG4108UK2 deaminase MLA2C4_22595 ENOG4105KQC Competence protein MLA2C4_22605 ENOG4105DXX methyltransferase MLA2C4_22615 ENOG4108WF2 Metal Dependent Phosphohydrolase MLA2C4_22625 ENOG410812S Rna-binding protein MLA2C4_22635 ENOG4105CQW ribosome biogenesis GTPase YqeH MLA2C4_22640 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase MLA2C4_22655 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MLA2C4_22685 ENOG4105G6Z alkaline phosphatase MLA2C4_22690 ENOG4105KEG ribosomal-protein-alanine acetyltransferase MLA2C4_22695 ENOG4108MUZ hydrolase MLA2C4_22730 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin MLA2C4_22735 ENOG4105MIR Phenylalanine 4-monooxygenase MLA2C4_22745 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase MLA2C4_22785 ENOG4105S6R Iron-hydroxamate transporter permease subunit MLA2C4_22790 ENOG4108V5C ABC transporter MLA2C4_22805 ENOG4108EKI Dehydrogenase MLA2C4_22810 ENOG4105C28 cystathionine MLA2C4_22840 ENOG4107XRG penicillin-binding protein MLA2C4_22855 ENOG4105CFP Peptidase U32 MLA2C4_22860 ENOG4105XYU peptidase (U32 family) MLA2C4_22865 ENOG4108VQJ O-methyltransferase MLA2C4_22870 ENOG4105HHA aminodeoxychorismate lyase MLA2C4_22880 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) MLA2C4_22900 ENOG4105C02 permease MLA2C4_22915 ENOG41060CR MLA2C4_22920 ENOG4105C7H Helicase, RecD TraA family MLA2C4_22935 ENOG4105C3J Cysteine desulfurase MLA2C4_22945 ENOG4105D1H recombination factor protein RarA MLA2C4_22950 ENOG4108VCI transcription factor, rsfa family MLA2C4_22960 ENOG4105CUZ uba thif-type nad fad binding protein MLA2C4_22970 ENOG4105CUT histidyl-tRNA synthetase MLA2C4_22980 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) MLA2C4_22990 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) MLA2C4_22995 ENOG41076HS cation diffusion facilitator family transporter MLA2C4_23000 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) MLA2C4_23010 ENOG4105CKP Polysaccharide Biosynthesis Protein MLA2C4_23015 ENOG4108QG2 Membrane MLA2C4_23025 ENOG4105VIE preprotein translocase, subunit YajC MLA2C4_23040 ENOG41061AI Protein of unknown function (DUF2905) MLA2C4_23055 ENOG4108HUF Transporter MLA2C4_23065 ENOG4108IPJ Membrane MLA2C4_23070 ENOG41082BM Transcriptional regulator, arsr family MLA2C4_23095 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase MLA2C4_23100 ENOG4108IYU L-aspartate oxidase MLA2C4_23115 ENOG4108RPX mosc domain containing protein MLA2C4_23120 ENOG4105CQC Prephenate dehydratase MLA2C4_23140 ENOG4105EWM Histidine kinase MLA2C4_23165 ENOG4105X36 (ribosomal) protein MLA2C4_23175 ENOG4105C03 ribonuclease MLA2C4_23190 ENOG4107QMS site-determining protein MLA2C4_23205 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) MLA2C4_23210 ENOG4105DFF Rod shape-determining protein mreb MLA2C4_23235 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase MLA2C4_23240 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) MLA2C4_23250 ENOG41068KH stage VI sporulation protein D MLA2C4_23260 ENOG4105D52 delta-aminolevulinic acid dehydratase MLA2C4_23285 ENOG4105K56 Transcriptional regulator MLA2C4_23305 ENOG4108IUQ atp-dependent protease MLA2C4_23330 ENOG4108QCI YvbH-like oligomerisation region MLA2C4_23360 ENOG4105M59 Phosphodiesterase, mj0936 family MLA2C4_23365 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) MLA2C4_23375 ENOG4108XJQ germination protein MLA2C4_23385 ENOG4105C57 major facilitator superfamily MLA2C4_23395 ENOG4105KBX Transcriptional regulator, TetR family MLA2C4_23405 ENOG4105PFC Transcriptional regulator MLA2C4_23415 ENOG4105DZC cytosine deaminase MLA2C4_23420 ENOG41067S9 phage shock protein C, PspC MLA2C4_23425 ENOG4108JCI Transcriptional regulator MLA2C4_23435 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) MLA2C4_23440 ENOG4108Z40 Transcriptional regulator MLA2C4_23445 ENOG4105RHA ABC transporter, permease MLA2C4_23450 ENOG4108IUX (ABC) transporter MLA2C4_23455 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family MLA2C4_23460 ENOG4105ER2 Ompa motb domain protein MLA2C4_23465 ENOG4105E14 MotA TolQ exbB proton channel MLA2C4_23470 ENOG4108VXD carboxy-peptidase MLA2C4_23480 ENOG4105E33 succinate dehydrogenase MLA2C4_23490 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit MLA2C4_23505 ENOG4105K63 Thioredoxin MLA2C4_23510 ENOG4105C10 Electron transfer flavoprotein MLA2C4_23515 ENOG4105BZJ Electron transfer flavoprotein MLA2C4_23520 ENOG41060WC Enoyl-CoA hydratase MLA2C4_23525 ENOG4107Z3H Transcriptional regulator, TetR family MLA2C4_23530 ENOG4105CEY Amp-dependent synthetase and ligase MLA2C4_23545 ENOG4105J76 Periplasmic binding protein MLA2C4_23550 ENOG4105S6R Iron-hydroxamate transporter permease subunit MLA2C4_23590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MLA2C4_23600 ENOG4105DR4 Methyltransferase MLA2C4_23610 ENOG4105KFN sortase, SrtB family MLA2C4_23615 ENOG4105E0A ABC, transporter MLA2C4_23630 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) MLA2C4_23635 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) MLA2C4_23645 ENOG4105FE9 pseudouridine synthase MLA2C4_23655 ENOG4105DCG PHP domain protein MLA2C4_23670 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) MLA2C4_23690 ENOG4105C5S asparaginyl-tRNA synthetase MLA2C4_23695 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) MLA2C4_23705 ENOG4108RWN rrna methyltransferase MLA2C4_23735 ENOG4105C0R drug resistance transporter emrb qaca subfamily MLA2C4_23740 ENOG4105CW7 secretion protein, HlyD family MLA2C4_23745 ENOG4108JGH Tetr family transcriptional regulator MLA2C4_23750 ENOG4105CN9 Peptidase m42 family protein MLA2C4_23760 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) MLA2C4_23770 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) MLA2C4_23775 ENOG4105C22 threonyL-tRNA synthetase MLA2C4_23780 ENOG4108TDW sporulation protein YtxC MLA2C4_23800 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) MLA2C4_23810 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase MLA2C4_23815 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) MLA2C4_23825 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) MLA2C4_23830 ENOG4105C2M dna polymerase I MLA2C4_23835 ENOG4105BZU Histidine kinase MLA2C4_23840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MLA2C4_23860 ENOG4108HMX isocitrate dehydrogenase (NADP) MLA2C4_23865 ENOG4105BZN citrate synthase MLA2C4_23880 ENOG4108REF Sporulation integral membrane protein ytvi MLA2C4_23885 ENOG4105FS0 cytoplasmic membrane protein MLA2C4_23910 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family MLA2C4_23915 ENOG4105C6K Malic enzyme MLA2C4_23920 ENOG4105C0B DNA polymerase III (alpha subunit) MLA2C4_23925 ENOG4105VV2 MLA2C4_23965 ENOG4105DC7 peptidase M24 MLA2C4_24005 ENOG41082W1 Cupin 2, conserved barrel domain protein MLA2C4_24015 ENOG4105VZ8 Transcriptional regulator MLA2C4_24035 ENOG4107YZX Universal stress protein MLA2C4_24075 ENOG4108JYZ YitT family MLA2C4_24095 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) MLA2C4_24105 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) MLA2C4_24110 ENOG4105KBJ sporulation protein ytfj MLA2C4_24125 ENOG4105EFZ amidohydrolase MLA2C4_24135 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MLA2C4_24160 ENOG4106KR7 LysR family Transcriptional regulator MLA2C4_24170 ENOG4105U5Y Transcriptional regulator MLA2C4_24180 ENOG4105C28 cystathionine MLA2C4_24185 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) MLA2C4_24210 ENOG4105EMN RNA polymerase sigma factor MLA2C4_24220 ENOG4108UW5 maltose o-acetyltransferase MLA2C4_24230 ENOG4105F1V Acetoin utilization protein MLA2C4_24235 ENOG4105W87 Cbs domain MLA2C4_24240 ENOG4105DGU Histone deacetylase MLA2C4_24260 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MLA2C4_24265 ENOG4105BZU Histidine kinase MLA2C4_24275 ENOG4105EP9 oxidoreductase MLA2C4_24305 ENOG4105ETE Transcriptional regulator (LacI family MLA2C4_24330 ENOG4105C88 aminopeptidase MLA2C4_24360 ENOG4108IPJ Membrane MLA2C4_24370 ENOG4105K7K Transcriptional regulator MLA2C4_24405 ENOG4108VDD TRNA binding domain protein MLA2C4_24435 ENOG4105C8F Beta-lactamase domain protein MLA2C4_24450 ENOG4108V15 phosphotransferase enzyme family MLA2C4_24455 ENOG4108IUM Glycogen debranching enzyme MLA2C4_24465 ENOG4107QSE Dipeptidase MLA2C4_24470 ENOG4105YW5 deoR family transcriptional regulator MLA2C4_24485 ENOG4105CBX hi0933 family MLA2C4_24495 ENOG4107A6P MLA2C4_24530 ENOG4108VJ1 Transcriptional regulator (CarD family MLA2C4_24535 ENOG4107EXU Short-chain dehydrogenase reductase Sdr MLA2C4_24555 ENOG4108ZAF Molybdopterin MLA2C4_24560 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein MLA2C4_24565 ENOG4105CVM Molybdenum cofactor synthesis domain protein MLA2C4_24575 ENOG4105D06 uba thif-type nad fad binding protein MLA2C4_24580 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MLA2C4_24600 ENOG41085GJ domain protein MLA2C4_24610 ENOG4105DWV Homoserine O-trans-acetylase MLA2C4_24645 ENOG4105C8T Leucyl-tRNA synthetase MLA2C4_24650 ENOG410605W Major Facilitator MLA2C4_24655 ENOG4107S91 Sodium hydrogen exchanger MLA2C4_24660 ENOG4105NCW Trka-c domain protein MLA2C4_24675 ENOG4105C19 ABC transporter MLA2C4_24700 ENOG4105N5T Radical SAM Protein MLA2C4_24710 ENOG4105DA5 (ABC) transporter MLA2C4_24730 ENOG4108RDQ ABC transporter MLA2C4_24770 ENOG4105E8V Alpha Beta Hydrolase Fold protein MLA2C4_24775 ENOG4108Z0R Transferase MLA2C4_24780 ENOG410841Q phosphoesterase PA-phosphatase related protein MLA2C4_24785 ENOG4105BZF Glycosyl transferase (Group 1 MLA2C4_24795 ENOG4108RIR Molybdenum cofactor biosynthesis protein MLA2C4_24845 ENOG4105BZU Histidine kinase MLA2C4_24850 ENOG4105BZU Histidine kinase MLA2C4_24855 ENOG4107S9D Alpha beta hydrolase MLA2C4_24875 ENOG4105D2X ABC transporter substrate-binding protein MLA2C4_24885 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component MLA2C4_24960 ENOG4108V2W Carbonate dehydratase MLA2C4_24965 ENOG4105C4M (Ubiquinol oxidase) subunit I MLA2C4_24970 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii MLA2C4_25015 ENOG41087YS Phage shock protein A MLA2C4_25040 ENOG4105N67 Proton-coupled thiamine transporter YuaJ MLA2C4_25045 ENOG4105BZU Histidine kinase MLA2C4_25050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MLA2C4_25075 ENOG4108UGV hypoxanthine phosphoribosyltransferase MLA2C4_25080 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) MLA2C4_25120 ENOG4107ZTW SNARE associated Golgi MLA2C4_25145 ENOG4105C19 ABC transporter MLA2C4_25150 ENOG41086D8 Transcriptional regulator MLA2C4_25160 ENOG41082BM Transcriptional regulator, arsr family MLA2C4_25200 ENOG4105C6Z Gluconate MLA2C4_25205 ENOG4105FDP GntR family transcriptional regulator MLA2C4_25225 ENOG41069H0 dihydroorotase EC 3.5.2.3 MLA2C4_25250 ENOG4105DTQ mandelate racemase muconate lactonizing MLA2C4_25260 ENOG4108IPT Naphthoate synthase MLA2C4_25265 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) MLA2C4_25275 ENOG4105E4F Isochorismate synthase MLA2C4_25280 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase MLA2C4_25290 ENOG4105VEQ Cold shock protein MLA2C4_25335 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin MLA2C4_25350 ENOG4105JVQ RNA Polymerase MLA2C4_25480 ENOG4105KT7 mgtC SapB transporter MLA2C4_25485 ENOG4107PBV potassium channel MLA2C4_25505 ENOG4105WG9 Conserved Protein MLA2C4_25515 ENOG4105CHM Aminotransferase MLA2C4_25520 ENOG4108ZB6 transcriptional regulator AsnC family MLA2C4_25525 ENOG4105C5I Dehydrogenase MLA2C4_25530 ENOG4108MUZ hydrolase MLA2C4_25540 ENOG4105C87 Aminotransferase class I and II MLA2C4_25550 ENOG4105Y38 Kinase-associated protein B MLA2C4_25560 ENOG4107R3E Citrate transporter MLA2C4_25575 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) MLA2C4_25580 ENOG4105KA0 thioesterase Superfamily protein MLA2C4_25600 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase MLA2C4_25620 ENOG41069ER domain protein MLA2C4_25635 ENOG4105CEP NADH dehydrogenase MLA2C4_25660 ENOG41080UQ Transcriptional regulator MLA2C4_25665 ENOG4108RWP Major Facilitator Superfamily protein MLA2C4_25675 ENOG4105EWC Purine nucleoside phosphorylase MLA2C4_25685 ENOG4108VQJ O-methyltransferase MLA2C4_25700 ENOG4108YX9 iron--sulfur cluster insertion protein erpA MLA2C4_25725 ENOG4108JJA ABC, transporter MLA2C4_25730 ENOG4105C4B ABC transporter, permease MLA2C4_25735 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA MLA2C4_25760 ENOG41083MR nifu domain-containing protein MLA2C4_25775 ENOG4108W5N phosphatidylglycerophosphatase a MLA2C4_25790 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) MLA2C4_25795 ENOG4105DYS nad(p)h dehydrogenase (quinone) MLA2C4_25805 ENOG4105D4U had-superfamily hydrolase, subfamily iia MLA2C4_25820 ENOG4105CBT Fructose-1,6-bisphosphatase MLA2C4_25835 ENOG4105C34 Pseudouridine synthase MLA2C4_25840 ENOG4105MMD transcriptional regulator MLA2C4_25845 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) MLA2C4_25850 ENOG4107TXC Transcriptional regulator MLA2C4_25855 ENOG41090T1 Membrane MLA2C4_25880 ENOG4105FAA peptidase M23 MLA2C4_25885 ENOG4108YTE sporulation protein YunB MLA2C4_25890 ENOG4105KZD Domain of unknown function (DUF1805) MLA2C4_25895 ENOG4107R8B 5'-nucleotidase MLA2C4_25905 ENOG4105DIW FeS assembly protein SUFB MLA2C4_25910 ENOG4108UNV SUF system FeS assembly protein, NifU family MLA2C4_25915 ENOG4105C9B Cysteine desulfurase MLA2C4_25920 ENOG4105JRK feS assembly protein SufD MLA2C4_25925 ENOG4105C3K feS assembly ATPase SufC MLA2C4_25930 ENOG4105D01 (LipO)protein MLA2C4_25935 ENOG4105D01 (LipO)protein MLA2C4_25940 ENOG4108UMI ABC transporter, permease MLA2C4_25970 ENOG41080E8 Transcriptional regulator, Spx MgsR family MLA2C4_26025 ENOG4108W8B Beta-lactamase domain protein MLA2C4_26030 ENOG4105C1G acyl-Coa dehydrogenase MLA2C4_26035 ENOG4105CHU acetyl-coa acetyltransferase MLA2C4_26050 ENOG4105DZ1 carboxypeptidase MLA2C4_26070 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer MLA2C4_26110 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MLA2C4_26115 ENOG4108FPN Integrase MLA2C4_26120 ENOG4108SUT Major Facilitator Superfamily MLA2C4_26125 ENOG4107R7I amino acid MLA2C4_26140 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins MLA2C4_26150 ENOG4107AYK membrAne MLA2C4_26190 ENOG4107ZTW SNARE associated Golgi MLA2C4_26200 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein MLA2C4_26205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MLA2C4_26210 ENOG4105BZU Histidine kinase MLA2C4_26225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) MLA2C4_26235 ENOG4105C8Q Methyl-accepting chemotaxis MLA2C4_26240 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer MLA2C4_26245 ENOG4105VG1 fes assembly suf system protein MLA2C4_26250 ENOG4105D4Y metalloprotease MLA2C4_26270 ENOG4107T5V SNARE associated Golgi MLA2C4_26275 ENOG4107S91 Sodium hydrogen exchanger MLA2C4_26280 ENOG4105NCW Trka-c domain protein MLA2C4_26290 ENOG4108RMU ferritin dps family protein MLA2C4_26300 ENOG4108URH decarboxylase MLA2C4_26320 ENOG4105D9N nucleoside MLA2C4_26330 ENOG4105D9N nucleoside MLA2C4_26345 ENOG4108RYK Nad-dependent epimerase dehydratase MLA2C4_26360 ENOG4105CV8 reductase MLA2C4_26365 ENOG4105F27 Major Facilitator MLA2C4_26370 ENOG4105KVH Transcriptional regulator MLA2C4_26385 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) MLA2C4_26390 ENOG4105D4A Cell wall formation (By similarity) MLA2C4_26400 ENOG4105C8Q Methyl-accepting chemotaxis MLA2C4_26435 ENOG4105C5H ABC transporter MLA2C4_26440 ENOG4108MK9 spermidine N(1)-acetyltransferase MLA2C4_26450 ENOG4108W2Y isochorismatase MLA2C4_26465 ENOG4108V2W Carbonate dehydratase MLA2C4_26470 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) MLA2C4_26485 ENOG4108IPW abc transporter atp-binding protein MLA2C4_26490 ENOG4105CM4 permease protein MLA2C4_26510 ENOG4105E1K spore germination protein MLA2C4_26535 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) MLA2C4_26545 ENOG4105XZU Preprotein translocase, subunit SecG MLA2C4_26550 ENOG41067MG lrgb family MLA2C4_26565 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) MLA2C4_26600 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MLA2C4_26620 ENOG41090VF Stage v sporulation protein ac MLA2C4_26625 ENOG4105CZ3 stage V sporulation protein ad MLA2C4_26640 ENOG4108QY0 Membrane MLA2C4_26645 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MLA2C4_26650 ENOG4105KRI phosphocarrier protein (HPr MLA2C4_26660 ENOG4105CHW UPF0052 protein MLA2C4_26670 ENOG4108Z4K mutator MutT protein MLA2C4_26680 ENOG4105C3M thioredoxin reductase MLA2C4_26690 ENOG4108S4C acetyltransferase MLA2C4_26710 ENOG41086DT Membrane protein of unknown function MLA2C4_26720 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) MLA2C4_26725 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) MLA2C4_26740 ENOG4107TXC Transcriptional regulator MLA2C4_26770 ENOG4105HMI Membrane MLA2C4_26775 ENOG4105DUM transcriptional regulator, lysR family MLA2C4_26785 ENOG4108WS4 fmn reductase MLA2C4_26800 ENOG4105BZ1 (ABC) transporter MLA2C4_26810 ENOG4105CN1 protease MLA2C4_26815 ENOG4105CRP Part of the ABC transporter FtsEX involved in MLA2C4_26820 ENOG4105CAK Cell division ATP-binding protein ftsE MLA2C4_26850 ENOG4105MS2 ribosomal subunit Interface protein MLA2C4_26855 ENOG4105VEQ Cold shock protein MLA2C4_26860 ENOG41081UC Inherit from COG: Competence protein MLA2C4_26875 ENOG4105KVH Transcriptional regulator MLA2C4_26885 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein MLA2C4_26890 ENOG4108KGH TRANSCRIPTIONal MLA2C4_26895 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase MLA2C4_26900 ENOG4105C6Y Udp-glucose 6-dehydrogenase MLA2C4_26905 ENOG4105ESV Glycosyl transferase, family 4 MLA2C4_26915 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family MLA2C4_26935 ENOG4105F8D glycoside hydrolase family 4 MLA2C4_26940 ENOG4105VCP PTS System MLA2C4_26945 ENOG4105CK1 PTS System MLA2C4_26955 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) MLA2C4_26960 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) MLA2C4_26970 ENOG4105VCP PTS System MLA2C4_26980 ENOG4105VZJ PTS System MLA2C4_26995 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase MLA2C4_27000 ENOG4105ECB domain protein MLA2C4_27005 ENOG4107RSM transcriptional regulator MLA2C4_27035 ENOG4105DAA L-lactate MLA2C4_27045 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) MLA2C4_27060 ENOG4105E0M Sulfatase MLA2C4_27085 ENOG4107R8N Glycosyl transferase, family 2 MLA2C4_27090 ENOG4105C94 Transporter MLA2C4_27100 ENOG41069ER domain protein MLA2C4_27125 ENOG4105KBK Zinc finger, swim domain protein MLA2C4_27130 ENOG4105C0D helicase MLA2C4_27160 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MLA2C4_27170 ENOG4107RBB ABC transporter, permease MLA2C4_27175 ENOG4105C19 ABC transporter MLA2C4_27185 ENOG4105CXY transporter MLA2C4_27200 ENOG4105BZU Histidine kinase MLA2C4_27205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MLA2C4_27210 ENOG4105DG6 mannose-6-phosphate isomerase MLA2C4_27215 ENOG4105DM4 PTS System MLA2C4_27225 ENOG4105CMR udp-glucose 4-epimerase MLA2C4_27235 ENOG4108KGH TRANSCRIPTIONal MLA2C4_27240 ENOG4105DG6 mannose-6-phosphate isomerase MLA2C4_27250 ENOG4105CJT Mannose-1-phosphate guanylyltransferase MLA2C4_27260 ENOG4107T8Q Glycosyl transferase (Group 1 MLA2C4_27280 ENOG4105C0K Gdp-mannose 4,6-dehydratase MLA2C4_27285 ENOG4105C30 Nad-dependent epimerase dehydratase MLA2C4_27290 ENOG4105D3Q Sugar transferase MLA2C4_27295 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase MLA2C4_27300 ENOG4108RB3 Capsular polysaccharide biosynthesis protein MLA2C4_27305 ENOG4107YJ4 chain length determinant protein MLA2C4_27310 ENOG4105HTX biosynthesis protein MLA2C4_27315 ENOG4108QV3 biosynthesis protein MLA2C4_27330 ENOG4105MT0 Sporulation transcriptional regulator spoiiid MLA2C4_27340 ENOG4105FRN stage II sporulation protein MLA2C4_27355 ENOG4105DY9 regulatoR MLA2C4_27380 ENOG4106778 Protein of unknown function (DUF1146) MLA2C4_27385 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MLA2C4_27390 ENOG4105C8S subunit m MLA2C4_27395 ENOG4105D65 subunit l MLA2C4_27420 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MLA2C4_27425 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain MLA2C4_27435 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain MLA2C4_27440 ENOG4105BZU Histidine kinase MLA2C4_27490 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) MLA2C4_27495 ENOG41062M3 atp synthase MLA2C4_27525 ENOG4108YZG isomerase MLA2C4_27540 ENOG4108VGI doxx family MLA2C4_27545 ENOG4107XC4 flavin reductase domain protein, FMN-binding MLA2C4_27565 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) MLA2C4_27575 ENOG4108ZXQ stage ii sporulation protein r MLA2C4_27580 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) MLA2C4_27595 ENOG4107104 thymidine kinase MLA2C4_27610 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) MLA2C4_27615 ENOG4105CBT Fructose-1,6-bisphosphatase MLA2C4_27620 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) MLA2C4_27655 ENOG4105C1G acyl-Coa dehydrogenase MLA2C4_27660 ENOG4105C1G acyl-Coa dehydrogenase MLA2C4_27665 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase MLA2C4_27675 ENOG4105DF6 Fe-S oxidoreductase MLA2C4_27690 ENOG4105BZU Histidine kinase MLA2C4_27715 ENOG4105BZU Histidine kinase MLA2C4_27720 ENOG4105KCT ABC transporter MLA2C4_27725 ENOG4108M15 ABC transporter MLA2C4_27730 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) MLA2C4_27735 ENOG4105IIU Aminopeptidase MLA2C4_27765 ENOG4105EMN RNA polymerase sigma factor MLA2C4_27795 ENOG4105CYW agmatinase MLA2C4_27805 ENOG4105DXB Major Facilitator superfamily MLA2C4_27810 ENOG4107SWG transcriptional regulator MERR family MLA2C4_27815 ENOG4108QXE glycerophosphoryl diester phosphodiesterase MLA2C4_27820 ENOG4105BZ4 penicillin-binding protein MLA2C4_27825 ENOG4108XFG YwhD family MLA2C4_27830 ENOG4108Z4T Peptidase M50 MLA2C4_27835 ENOG41069HH 4-oxalocrotonate tautomerase MLA2C4_27840 ENOG4105DCI Phosphohydrolase MLA2C4_27845 ENOG4108V5C ABC transporter MLA2C4_27850 ENOG4105E0A ABC, transporter MLA2C4_27855 ENOG4105EHG Permease protein MLA2C4_27860 ENOG4105DQ5 transport system permease protein MLA2C4_27870 ENOG4108VCI transcription factor, rsfa family MLA2C4_27880 ENOG41085FC arsR family transcriptional regulator MLA2C4_27885 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase MLA2C4_27890 ENOG4105D6J arsenicaL-resistance protein MLA2C4_27900 ENOG4105ZX1 Transposase C MLA2C4_27905 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MLA2C4_27910 ENOG4108FPN Integrase MLA2C4_27915 ENOG4108IJ2 phosphate acetyltransferase MLA2C4_27920 ENOG4107UEZ chlorite dismutase MLA2C4_27930 ENOG4108VKI Cell wall hydrolase MLA2C4_27950 ENOG4107SVH Potassium channel protein MLA2C4_27960 ENOG410667J hydrolase MLA2C4_27965 ENOG4105VCH membrane MLA2C4_27975 ENOG4108TU7 Inherit from COG: (ABC) transporter MLA2C4_27980 ENOG4105CJ1 ABC, transporter MLA2C4_27985 ENOG41090WU lipolytic protein G-D-S-L family MLA2C4_28000 ENOG4105D6E homoserine dehydrogenase MLA2C4_28025 ENOG4108Y4K DNA-binding transcriptional activator MLA2C4_28035 ENOG4105WH1 Two component transcriptional regulator luxr family MLA2C4_28040 ENOG4105BZU Histidine kinase MLA2C4_28045 ENOG4105DWF phosphomethylpyrimidine kinase MLA2C4_28060 ENOG4105VCD cytoplasmic protein MLA2C4_28065 ENOG4105D22 carbon starvation protein MLA2C4_28070 ENOG4105DY9 regulatoR MLA2C4_28075 ENOG41079KZ Major Facilitator Superfamily MLA2C4_28095 ENOG4105EN6 Membrane MLA2C4_28100 ENOG4106YBV Methyl-accepting chemotaxis MLA2C4_28110 ENOG4108S4H thioesterase Superfamily protein MLA2C4_28120 ENOG4105JEU Glycosyl transferase, family 2 MLA2C4_28125 ENOG4105C5H ABC transporter MLA2C4_28145 ENOG4105CKK Glycosyl transferase, family 2 MLA2C4_28150 ENOG41067SE Tetr family transcriptional regulator MLA2C4_28160 ENOG4105E0X reductase MLA2C4_28165 ENOG4106F5Q Membrane MLA2C4_28175 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) MLA2C4_28180 ENOG4105DY9 regulatoR MLA2C4_28185 ENOG4108HRK Histidine kinase MLA2C4_28190 ENOG4107RGD Major Facilitator superfamily MLA2C4_28210 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) MLA2C4_28220 ENOG4105IW1 AmiS UreI transporter MLA2C4_28260 ENOG4105CMR udp-glucose 4-epimerase MLA2C4_28265 ENOG4108UT2 hemolysin iii MLA2C4_28280 ENOG4105C1J atp-dependent rna helicase MLA2C4_28295 ENOG4105DPN Oligoendopeptidase f MLA2C4_28325 ENOG4105C0H protease MLA2C4_28330 ENOG4105Q2H domain protein MLA2C4_28345 ENOG4105BZU Histidine kinase MLA2C4_28350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MLA2C4_28375 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis MLA2C4_28380 ENOG4105CDU Replicative dna helicase MLA2C4_28390 ENOG4105BZR domain protein MLA2C4_28395 ENOG4108XMW Membrane MLA2C4_28405 ENOG4108UUM single-stranded DNA-binding protein MLA2C4_28415 ENOG4105C3G gtp-binding protein MLA2C4_28420 ENOG4105VDK protein, conserved in bacteria MLA2C4_28425 ENOG4105D8X mechanosensitive ion channel MLA2C4_28430 ENOG4108ZDA Sporulation protein YyaC MLA2C4_28435 ENOG4105FA0 parb-like partition protein MLA2C4_28440 ENOG4107QJE Chromosome Partitioning Protein MLA2C4_28470 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins