locus-tag class description HC660_00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HC660_00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HC660_00030 ENOG410848D S4 domain protein YaaA HC660_00060 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HC660_00070 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HC660_00140 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HC660_00160 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HC660_00170 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HC660_00180 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HC660_00200 ENOG4105ZMH deoxynucleoside kinase HC660_00220 ENOG4105VRS hydrolase family 18 HC660_00230 ENOG4105GTG Isochorismatase HC660_00240 ENOG4108Z6B deaminase HC660_00250 ENOG4105C6E dna polymerase iii HC660_00260 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HC660_00270 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HC660_00290 ENOG41067KS pro-sigma K processing HC660_00370 ENOG4105CDW Resistance protein HC660_00380 ENOG4105CXN decarboxylase HC660_00390 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HC660_00400 ENOG4105X0R protein from nitrogen regulatory protein P-II HC660_00410 ENOG4105XVJ Protein of unknown function (DUF327) HC660_00420 ENOG4105FA2 dna polymerase iii HC660_00430 ENOG4105MA4 psp1 domain protein HC660_00450 ENOG41060K3 Methyltransferase HC660_00460 ENOG4105VC4 domain protein HC660_00470 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HC660_00480 ENOG4105KRN Transcriptional regulator, abrb family HC660_00490 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HC660_00500 ENOG4105F8V Hydrolase, tatD family HC660_00510 ENOG41069ER domain protein HC660_00530 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HC660_00540 ENOG4105XFA sporulation peptidase YabG HC660_00550 ENOG4105W42 Veg protein HC660_00560 ENOG4105XEW small acid-soluble spore protein HC660_00570 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HC660_00580 ENOG4105DFT pur operon repressor HC660_00590 ENOG4105KME endoribonuclease L-psp HC660_00600 ENOG4105K4W Could be involved in septation (By similarity) HC660_00610 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HC660_00620 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HC660_00630 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HC660_00640 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HC660_00660 ENOG4108JA2 transcriptioN-repair coupling factor HC660_00670 ENOG4108M14 stage v sporulation protein t HC660_00690 ENOG4108IY2 MazG family HC660_00700 ENOG41082I2 s4 domain protein HC660_00710 ENOG4105VYY sporulation protein yabp HC660_00740 ENOG41060GV RNA binding s1 domain protein HC660_00800 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HC660_00810 ENOG4108UGV hypoxanthine phosphoribosyltransferase HC660_00820 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HC660_00840 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HC660_00850 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HC660_00860 ENOG4105C6T cysteine synthase HC660_00870 ENOG4105CRQ synthase (Component I) HC660_00880 ENOG4105DDQ anthranilate synthase HC660_00890 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HC660_00900 ENOG4105EEI dihydropteroate synthase HC660_00910 ENOG4105KRF dihydroneopterin aldolase HC660_00920 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HC660_00940 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HC660_00950 ENOG4105CRK lysyL-tRNA synthetase HC660_01120 ENOG4108Z0C Uvrb UvrC protein HC660_01130 ENOG41066A3 ATP guanido phosphotransferase HC660_01150 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HC660_01160 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HC660_01170 ENOG4105CTP PilT protein domain protein HC660_01180 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HC660_01190 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HC660_01200 ENOG4105D7W serine acetyltransferase HC660_01210 ENOG4105C8N cysteinyl-tRNA synthetase HC660_01220 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HC660_01230 ENOG4105C2N RNA methyltransferase TrmH family group 3 HC660_01240 ENOG4105M0M Tetracycline resistance protein HC660_01270 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HC660_01300 ENOG4108VZM 50s ribosomal protein L10 HC660_01320 ENOG4107Y49 methyltransferase HC660_01330 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HC660_01340 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HC660_01350 ENOG4105XPM ribosomal protein HC660_01360 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HC660_01370 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HC660_01380 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HC660_01390 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HC660_01400 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HC660_01410 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HC660_01420 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HC660_01430 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HC660_01450 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HC660_01480 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HC660_01490 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HC660_01510 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HC660_01520 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HC660_01540 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HC660_01560 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HC660_01570 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HC660_01580 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HC660_01590 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HC660_01610 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HC660_01620 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HC660_01640 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HC660_01660 ENOG41067V7 50S ribosomal protein L36 HC660_01670 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HC660_01680 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HC660_01690 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HC660_01700 ENOG4108ZT0 50S ribosomal protein l17 HC660_01710 ENOG4108JJB ABC transporter HC660_01720 ENOG4108JJB ABC transporter HC660_01730 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HC660_01740 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HC660_01750 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HC660_01760 ENOG4108UJD 30S ribosomal protein S9 HC660_01770 ENOG4108I0C methyltransferase HC660_01800 ENOG4105D1F ATP-binding protein HC660_01830 ENOG4108NMV polysaccharide deacetylase HC660_01990 ENOG4105CHH sulfate transporter HC660_02010 ENOG4108SA1 esterase HC660_02050 ENOG410874W AraC family transcriptional regulator HC660_02060 ENOG4105EHZ conserved protein UCP016719 HC660_02070 ENOG4105D17 glycoside hydrolase, family 3 domain protein HC660_02110 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HC660_02130 ENOG4105EWC Purine nucleoside phosphorylase HC660_02190 ENOG4105EMN RNA polymerase sigma factor HC660_02210 ENOG4105C8B TIGR00159 family HC660_02220 ENOG4107U5W ybbr family HC660_02230 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HC660_02250 ENOG4105D03 DNA-3-methyladenine glycosylase II HC660_02270 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HC660_02280 ENOG4108TWJ NADH dehydrogenase subunit 5 HC660_02320 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HC660_02330 ENOG4105WAB arsR family transcriptional regulator HC660_02340 ENOG4108RWP Major Facilitator Superfamily protein HC660_02390 ENOG4105G0J serine threonine protein kinase HC660_02410 ENOG4106K80 HC660_02430 ENOG4106DDH Sporulation-specific SASP protein HC660_02450 ENOG4108HWY Beta-lactamase HC660_02460 ENOG4107E6A Cytochrome p-450 HC660_02480 ENOG4107QTZ amino acid HC660_02500 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HC660_02510 ENOG4105CXY transporter HC660_02530 ENOG410645S MarR family Transcriptional regulator HC660_02540 ENOG4105DCM major facilitator superfamily HC660_02570 ENOG4107SCQ Iron-containing alcohol dehydrogenase HC660_02580 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HC660_02590 ENOG4108TCS Glutamyl endopeptidase HC660_02610 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HC660_02620 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HC660_02630 ENOG4107ZTW SNARE associated Golgi HC660_02680 ENOG4105C72 UPF0176 protein HC660_02700 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane HC660_02710 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HC660_02740 ENOG4105CM2 brancheD-chain amino acid aminotransferase HC660_02750 ENOG4108IQI permease HC660_02760 ENOG4108J5H Homocysteine s-methyltransferase HC660_02780 ENOG4105CSV Glutaminase HC660_02810 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HC660_02820 ENOG4105C26 Dehydrogenase HC660_02830 ENOG4105DJB Major Facilitator Superfamily HC660_02840 ENOG4105EQX glucarate dehydratase HC660_02850 ENOG41073TP transcriptional regulator HC660_02860 ENOG4105CTX dehydratase HC660_02890 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HC660_02960 ENOG4105MUA Resistance protein HC660_02970 ENOG4105DGI Alkaline phosphatase HC660_02980 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HC660_02990 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HC660_03000 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HC660_03010 ENOG4107EPV Aminotransferase class V HC660_03020 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC660_03030 ENOG4105J7D transcriptional regulator HC660_03040 ENOG4107RB3 L-asparaginase HC660_03050 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HC660_03070 ENOG41060AI SEC-C motif HC660_03090 ENOG4107Y7X LytTR HC660_03100 ENOG4108IUW ABC transporter HC660_03110 ENOG4108SDH ABC, transporter HC660_03120 ENOG4107SET aldo keto reductase HC660_03180 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HC660_03200 ENOG4105DSE periplasmic solute binding protein HC660_03210 ENOG4105DIK (ABC) transporter HC660_03230 ENOG4105DEN Luciferase family HC660_03240 ENOG4108N0M stress protein HC660_03250 ENOG4106FN3 tellurium resistance protein HC660_03260 ENOG4106FN3 tellurium resistance protein HC660_03270 ENOG4107TS3 membrane protein, TerC HC660_03300 ENOG4105DAX Pfam:DUF2983 HC660_03320 ENOG4108TTB tellurium resistance protein HC660_03340 ENOG41079KZ Major Facilitator Superfamily HC660_03350 ENOG4108IJ7 Glycine betaine HC660_03360 ENOG4107SQ8 Glycine betaine HC660_03410 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HC660_03480 ENOG4105EIG urea carboxylase-associated protein 1 HC660_03490 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HC660_03500 ENOG4105I1F Resistance protein HC660_03510 ENOG4108WBH protein TIM barrel HC660_03520 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HC660_03530 ENOG4105C5Q Transcriptional regulator HC660_03540 ENOG4105C5Q Transcriptional regulator HC660_03550 ENOG4105I82 acetyl xylan esterase HC660_03560 ENOG410756H nucleotidyltransferase HC660_03580 ENOG4105C26 Dehydrogenase HC660_03590 ENOG4105CK7 Sodium proline symporter HC660_03600 ENOG4107YHD transcriptional regulator HC660_03620 ENOG4108PJD permease HC660_03630 ENOG4105U6C Alpha beta hydrolase fold protein HC660_03650 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HC660_03660 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HC660_03670 ENOG4108IFG nitrite reductase, (NAD(P)H) HC660_03680 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HC660_03740 ENOG4105CKI cobalamin synthesis protein HC660_03750 ENOG4105E5Q amino acid AbC transporter HC660_03760 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein HC660_03770 ENOG4105HHM rdd domain containing protein HC660_03790 ENOG4105K56 Transcriptional regulator HC660_03800 ENOG4108VEN abc transporter atp-binding protein HC660_03810 ENOG4105CS2 ec 3.2.1.21 HC660_03840 ENOG4105C8Q Methyl-accepting chemotaxis HC660_03850 ENOG41080HJ 6-phospho 3-hexuloisomerase HC660_03860 ENOG4108VA3 3-hexulose-6-phosphate synthase HC660_03870 ENOG4105KVH Transcriptional regulator HC660_03880 ENOG4105CEY Amp-dependent synthetase and ligase HC660_03940 ENOG4105SX7 Transporter HC660_03980 ENOG4108PJD permease HC660_04000 ENOG4105CDA abc transporter atp-binding protein HC660_04010 ENOG4105DRP amino acid AbC transporter HC660_04030 ENOG4106P55 Transcriptional regulator HC660_04040 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HC660_04050 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HC660_04060 ENOG41069ZX HC660_04070 ENOG41069ZX HC660_04090 ENOG4105DUX Transporter HC660_04120 ENOG4105E1K spore germination protein HC660_04160 ENOG4107WD8 ABC transporter, permease HC660_04170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HC660_04180 ENOG4105BZU Histidine kinase HC660_04210 ENOG4105CFH Aspartokinase HC660_04220 ENOG4105DHS permease protein HC660_04230 ENOG4105CM4 permease protein HC660_04240 ENOG4108IPW abc transporter atp-binding protein HC660_04270 ENOG4105R8C Transcriptional regulator HC660_04280 ENOG4108DBC nitroreductase HC660_04290 ENOG41067V3 Antibiotic biosynthesis monooxygenase HC660_04300 ENOG4105YVS arsR family transcriptional regulator HC660_04320 ENOG4108JPW Aminotransferase HC660_04330 ENOG4105C26 Dehydrogenase HC660_04350 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HC660_04360 ENOG4105KTB nuclear export factor GLE1 HC660_04370 ENOG4108T5E Copper resistance protein HC660_04380 ENOG4108ZYE Transcriptional regulator HC660_04430 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HC660_04440 ENOG4108ZX0 Signal peptidase I HC660_04480 ENOG4105E7W lamb ycsf family protein HC660_04490 ENOG4105C5A transporter HC660_04500 ENOG4105CFM UPF0317 protein HC660_04510 ENOG4105P4J Allophanate hydrolase, subunit 1 HC660_04530 ENOG4107258 Transcriptional regulator HC660_04540 ENOG4105XJB lipolytic protein G-D-S-L family HC660_04560 ENOG41061CK Antibiotic biosynthesis monooxygenase HC660_04570 ENOG4107RVG penicillin-binding protein HC660_04580 ENOG4107QM2 Aldo Keto reductase HC660_04590 ENOG4105ETD TRANSCRIPTIONal HC660_04610 ENOG4105HMZ Methyltransferase HC660_04620 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HC660_04650 ENOG410606W general stress protein HC660_04670 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HC660_04680 ENOG4105VCH membrane HC660_04700 ENOG4105C9U ATP-dependent DNA helicase RecQ HC660_04730 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HC660_04740 ENOG4107R8N Glycosyl transferase, family 2 HC660_04760 ENOG4105C0X amino acid HC660_04800 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HC660_04810 ENOG4107BMA Transglycosylase associated protein HC660_04820 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HC660_04830 ENOG4105EU9 HC660_04840 ENOG4105QVS general stress protein HC660_04850 ENOG41082W1 Cupin 2, conserved barrel domain protein HC660_04890 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HC660_04900 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HC660_04910 ENOG4108MRH transcriptional regulatory protein HC660_04920 ENOG4107QJT sodium dicarboxylate symporter HC660_04930 ENOG4106F5Q Membrane HC660_04950 ENOG4105CJ1 ABC, transporter HC660_04980 ENOG4105FDT acyl-CoA dehydrogenase HC660_05020 ENOG4105SZ6 Thioredoxin HC660_05030 ENOG4105CPF Cell wall formation (By similarity) HC660_05040 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HC660_05050 ENOG4105C1J atp-dependent rna helicase HC660_05060 ENOG410905X membrane-flanked domain protein HC660_05070 ENOG4105CKV Membrane HC660_05090 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HC660_05100 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HC660_05110 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HC660_05130 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HC660_05140 ENOG4107MMM Anti-sigma-factor antagonist HC660_05150 ENOG4105FUA antagonist HC660_05160 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HC660_05170 ENOG4107SGM protein serine threonine phosphatase HC660_05180 ENOG4105WN5 stage II sporulation protein HC660_05190 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HC660_05210 ENOG41064BQ Phosphatase HC660_05330 ENOG4106DF4 Sigma-70, region 4 HC660_05350 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HC660_05360 ENOG4108IMY Transcriptional regulator HC660_05400 ENOG4108RYM conjugative transposon protein HC660_05410 ENOG4106BHR ftsk SpoIIIE family protein HC660_05420 ENOG4106128 DNA-binding helix-turn-helix protein HC660_05500 ENOG4105P1M Domain of unknown function (DUF1874) HC660_05520 ENOG4105K4H Nlp p60 protein HC660_05560 ENOG4105NI8 Cytosine-specific methyltransferase HC660_05590 ENOG4105DRR Transcriptional regulator, GntR family HC660_05600 ENOG4106BHF HC660_05610 ENOG4105K4H Nlp p60 protein HC660_05620 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HC660_05630 ENOG4105DEN Luciferase family HC660_05650 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HC660_05660 ENOG4108HH4 Major Facilitator Superfamily HC660_05680 ENOG4105ECK Fatty Acid Desaturase HC660_05690 ENOG4108VJ1 Transcriptional regulator (CarD family HC660_05700 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HC660_05720 ENOG4105CZ9 Domain of unknown function (DU1801) HC660_05730 ENOG4105GIG HC660_05750 ENOG4108U05 Transcriptional regulator HC660_05760 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HC660_05790 ENOG4108V4B ThiJ pfpI HC660_05800 ENOG4105T38 integral membrane protein HC660_05810 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HC660_05820 ENOG41085FC arsR family transcriptional regulator HC660_05830 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HC660_05880 ENOG4105DM4 PTS System HC660_05890 ENOG4105DG6 mannose-6-phosphate isomerase HC660_05900 ENOG4108ZMQ domain protein HC660_05910 ENOG4107Y9U Membrane HC660_05930 ENOG4105Z7P Acetyltransferase (GNAT) family HC660_05950 ENOG4108TVJ Nitroreductase HC660_05960 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HC660_05970 ENOG4108VGI doxx family HC660_05980 ENOG4105XXY Thioredoxin HC660_05990 ENOG4105WQG acetyltransferase HC660_06010 ENOG4105C85 amino acid HC660_06030 ENOG41062A4 Transcriptional regulator HC660_06040 ENOG4105EYF MMPL domain protein HC660_06060 ENOG4108TVJ Nitroreductase HC660_06070 ENOG4105FS7 Transcriptional regulator HC660_06080 ENOG4108JCI Transcriptional regulator HC660_06100 ENOG4105C2C drug resistance transporter, Bcr CflA HC660_06120 ENOG4105DRR Transcriptional regulator, GntR family HC660_06130 ENOG4105VRS hydrolase family 18 HC660_06170 ENOG4105G6Z alkaline phosphatase HC660_06180 ENOG4107TVP HD domain protein HC660_06190 ENOG41090UD (LipO)protein HC660_06200 ENOG4105F27 Major Facilitator HC660_06210 ENOG4105VZJ PTS System HC660_06220 ENOG4105VCP PTS System HC660_06230 ENOG4105CK1 PTS System HC660_06240 ENOG4105CS2 ec 3.2.1.21 HC660_06250 ENOG4108TZY GntR Family Transcriptional Regulator HC660_06260 ENOG4105EVU fructokinase HC660_06270 ENOG4105DG6 mannose-6-phosphate isomerase HC660_06280 ENOG4105D3P Mannan endo-1,4-beta-mannosidase HC660_06370 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HC660_06380 ENOG4105K8N protein family UPF0079, ATPase HC660_06390 ENOG41072GX Peptidase M22 Glycoprotease HC660_06400 ENOG410801F ribosomal-protein-alanine acetyltransferase HC660_06410 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HC660_06420 ENOG4105C5H ABC transporter HC660_06430 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HC660_06440 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HC660_06450 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HC660_06460 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HC660_06480 ENOG4108TYN CAAX amino terminal protease family protein HC660_06500 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HC660_06520 ENOG4105PGZ NB-ARC domain HC660_06530 ENOG4105CPQ Dehydrogenase HC660_06540 ENOG4105CT4 transporter HC660_06560 ENOG4108ZMR Ion transport 2 domain-containing protein HC660_06570 ENOG4107QNK )-transporter HC660_06630 ENOG4107YUH hydrolase HC660_06650 ENOG4107STQ Multicopper oxidase HC660_06660 ENOG4105C85 amino acid HC660_06680 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HC660_06720 ENOG4105C7N Xanthine uracil vitamin C permease HC660_06770 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HC660_06780 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HC660_06790 ENOG4105C83 adenylosuccinate lyase HC660_06800 ENOG4105C8V SAICAR synthetase HC660_06810 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HC660_06820 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HC660_06830 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HC660_06850 ENOG4105CXB phosphoribosylaminoimidazole synthetase HC660_06860 ENOG4108V3E phosphoribosylglycinamide formyltransferase HC660_06870 ENOG4105DC1 bifunctional purine biosynthesis protein purh HC660_06880 ENOG4105C12 Phosphoribosylglycinamide synthetase HC660_06900 ENOG4105DVH amino acid HC660_06930 ENOG4108R5T secreted protein HC660_06940 ENOG4105KGF protein, YerC YecD HC660_06950 ENOG4105CBC glutamate synthase HC660_06960 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) HC660_06970 ENOG4105C4R Atp-dependent dna helicase HC660_06980 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HC660_07030 ENOG4105CRN Aminoglycoside phosphotransferase HC660_07040 ENOG4105KT7 mgtC SapB transporter HC660_07050 ENOG4105CK7 Sodium proline symporter HC660_07060 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HC660_07070 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HC660_07080 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HC660_07090 ENOG4108IG5 Transcriptional regulator HC660_07110 ENOG4105CBD Diacylglycerol kinase HC660_07120 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HC660_07160 ENOG4105DZR Type I site-specific deoxyribonuclease HC660_07290 ENOG4105CDY transcriptional regulatory protein HC660_07310 ENOG4105M4P Tetr family transcriptional regulator HC660_07320 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HC660_07330 ENOG4107S9F NmrA family HC660_07340 ENOG4105KHM amidohydrolase 2 HC660_07350 ENOG4105ST3 Transcriptional regulator HC660_07380 ENOG4105WEF catalase HC660_07390 ENOG4105M18 -acetyltransferase HC660_07420 ENOG4105C2F Histidine kinase HC660_07430 ENOG4105EQD regulatoR HC660_07440 ENOG410769Z extracellular solute-binding protein family 1 HC660_07450 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HC660_07460 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HC660_07470 ENOG4105F5H Glycosyl Hydrolase Family 88 HC660_07480 ENOG41075H3 AraC family transcriptional regulator HC660_07490 ENOG4107TDE lipolytic protein G-D-S-L family HC660_07520 ENOG4105CX8 fg-gap repeat protein HC660_07530 ENOG4105CX8 fg-gap repeat protein HC660_07540 ENOG4105CPC Aldo Keto reductase HC660_07550 ENOG4107TDE lipolytic protein G-D-S-L family HC660_07570 ENOG4105EKC HC660_07580 ENOG4105E0S extracellular solute-binding protein family 1 HC660_07600 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HC660_07610 ENOG4105F8D glycoside hydrolase family 4 HC660_07620 ENOG4105H67 Protein of unknown function (DUF421) HC660_07630 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HC660_07670 ENOG4106I4J membrane HC660_07680 ENOG41082F9 transcriptional regulator HC660_07690 ENOG41061H0 Monooxygenase HC660_07710 ENOG4108R1P HC660_07720 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HC660_07730 ENOG4105E0M Sulfatase HC660_07740 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HC660_07760 ENOG41090R9 glycosyltransferase HC660_07770 ENOG4107R51 Glycosyl transferase, family 2 HC660_07780 ENOG41090R9 glycosyltransferase HC660_07790 ENOG4105EU0 Major facilitator Superfamily HC660_07810 ENOG4105CUB amino acid HC660_07820 ENOG4105C26 Dehydrogenase HC660_07830 ENOG4105FKZ Methyl-accepting chemotaxis HC660_07840 ENOG4105C5H ABC transporter HC660_07860 ENOG4107SWG transcriptional regulator MERR family HC660_07870 ENOG4105DXB Major Facilitator superfamily HC660_07900 ENOG4105C5H ABC transporter HC660_07910 ENOG4105FDU atp-dependent rna helicase HC660_07930 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HC660_07940 ENOG4105E0A ABC, transporter HC660_07950 ENOG4108U1V ABC transporter, permease HC660_07960 ENOG4105DQ5 transport system permease protein HC660_07970 ENOG4108HUF Transporter HC660_08000 ENOG4108J20 pectate lyase HC660_08010 ENOG4107QPK )-transporter HC660_08050 ENOG4106WTF Glycosyl transferase, family 2 HC660_08060 ENOG4107RGC Glycosyl transferase, family 2 HC660_08080 ENOG4108MRH transcriptional regulatory protein HC660_08130 ENOG410855V Acylphosphatase HC660_08140 ENOG4108RPX mosc domain containing protein HC660_08180 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HC660_08230 ENOG4105C5Y PTS System HC660_08240 ENOG4105CG3 alpha amylase, catalytic region HC660_08250 ENOG4107414 GntR family transcriptional regulator HC660_08260 ENOG4108RCM Nitroreductase HC660_08270 ENOG4105CGH 5'-nucleotidase HC660_08280 ENOG4107RKG DJ-1/PfpI family HC660_08310 ENOG4105KJF protein tyrosine phosphatase HC660_08330 ENOG4107U9T Pfam:Ribonuclease_BN HC660_08340 ENOG4108ISG Major Facilitator HC660_08350 ENOG4105UPD Calcium Proton HC660_08370 ENOG4105D8X mechanosensitive ion channel HC660_08410 ENOG4106KE4 Dehydrogenase HC660_08420 ENOG4105D7N magnesium and cobalt transport protein CorA HC660_08440 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HC660_08470 ENOG4107RUY (E1 component), alpha subunit HC660_08490 ENOG4107QKR Dehydrogenase HC660_08510 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HC660_08520 ENOG41069DP small acid-soluble spore protein HC660_08530 ENOG4105KK4 UPF0060 membrane protein HC660_08580 ENOG4105F8D glycoside hydrolase family 4 HC660_08590 ENOG4108Q3X Transcriptional regulator HC660_08600 ENOG4105CI1 PTS System HC660_08610 ENOG4105BZ1 (ABC) transporter HC660_08620 ENOG4105BZ1 (ABC) transporter HC660_08640 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HC660_08650 ENOG4105BZU Histidine kinase HC660_08660 ENOG4105WH1 Two component transcriptional regulator luxr family HC660_08670 ENOG4105CJ1 ABC, transporter HC660_08680 ENOG41090VJ ABC-2 type transporter HC660_08690 ENOG4108KYE ABC-2 type transporter HC660_08700 ENOG4105U3E Transcriptional regulator HC660_08710 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HC660_08720 ENOG4105H93 Acyltransferase family HC660_08730 ENOG4108YYS metal-dependent hydrolase (By similarity) HC660_08740 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC660_08750 ENOG410834F Transcriptional regulator HC660_08770 ENOG4108MES Periplasmic binding protein HC660_08780 ENOG4105DQ5 transport system permease protein HC660_08790 ENOG4108IHU transport system permease protein HC660_08800 ENOG4105JAB phenazine biosynthesis protein, phzf family HC660_08810 ENOG4107Y03 Nitroreductase HC660_08840 ENOG4105ECP epimerase HC660_08870 ENOG4105F27 Major Facilitator HC660_08910 ENOG4106AKJ HC660_08920 ENOG4105D74 hydrolase HC660_08930 ENOG4105CKK Glycosyl transferase, family 2 HC660_08940 ENOG4105EJV Membrane HC660_08950 ENOG41067AE Membrane-bound metal-dependent hydrolase HC660_08960 ENOG4105CEN a g-specific adenine glycosylase HC660_08970 ENOG4106BXE HC660_08980 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HC660_09010 ENOG4105EVI UPF0374 protein HC660_09020 ENOG4105BZ1 (ABC) transporter HC660_09030 ENOG4107NBY Membrane HC660_09050 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HC660_09060 ENOG4105G5W regulator Fur family HC660_09310 ENOG4108N23 SpoOM-related protein HC660_09330 ENOG4105E2A Dehydrogenase HC660_09340 ENOG4105PGS Spore coat protein HC660_09360 ENOG4105EC3 peptidase S51, dipeptidase E HC660_09370 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HC660_09400 ENOG4105E2Y ABC, transporter HC660_09410 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HC660_09420 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HC660_09430 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HC660_09450 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HC660_09460 ENOG4107D63 HC660_09470 ENOG4105VZ8 Transcriptional regulator HC660_09500 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HC660_09520 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HC660_09560 ENOG4105CYN Serine protein kinase HC660_09570 ENOG4106AKX UPF0229 protein HC660_09580 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HC660_09590 ENOG4105CW7 secretion protein, HlyD family HC660_09600 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC660_09610 ENOG4105CS1 NAD(P)H quinone oxidoreductase HC660_09640 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HC660_09650 ENOG4105CZV ABC transporter HC660_09660 ENOG4105CJ1 ABC, transporter HC660_09670 ENOG4108TU7 Inherit from COG: (ABC) transporter HC660_09680 ENOG4105VEQ Cold shock protein HC660_09700 ENOG4105BZU Histidine kinase HC660_09720 ENOG41067SE Tetr family transcriptional regulator HC660_09730 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HC660_09790 ENOG4108YBP pseudouridine synthase HC660_09810 ENOG41080XP Cbs domain HC660_09820 ENOG4107YBY Hydrolase HC660_09830 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HC660_09850 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HC660_09860 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HC660_09880 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HC660_09890 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HC660_09910 ENOG4105BZU Histidine kinase HC660_09920 ENOG4105WH1 Two component transcriptional regulator luxr family HC660_09980 ENOG4105ED1 spovr family HC660_09990 ENOG4105G6Z alkaline phosphatase HC660_10020 ENOG4105BZN citrate synthase HC660_10030 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HC660_10040 ENOG4105CUB amino acid HC660_10050 ENOG4105C8J )-transporter HC660_10060 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HC660_10090 ENOG4105J37 HC660_10100 ENOG4108AEY RNA polymerase sigma factor HC660_10110 ENOG4108FN7 Aldo keto reductase HC660_10120 ENOG4105F6E Acyl-transferase HC660_10130 ENOG4107VFR oxidoreductase HC660_10140 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HC660_10150 ENOG4105C37 (CBS) domain HC660_10170 ENOG4105CHM Aminotransferase HC660_10180 ENOG4105C37 (CBS) domain HC660_10200 ENOG4105WMR Protein CrcB homolog HC660_10210 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HC660_10230 ENOG4105D64 Mechanosensitive ion channel HC660_10240 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HC660_10250 ENOG4107VMI polysaccharide deacetylase HC660_10260 ENOG4105F0I Aminotransferase HC660_10290 ENOG4105BZ1 (ABC) transporter HC660_10300 ENOG4105BZ1 (ABC) transporter HC660_10340 ENOG410839P HC660_10360 ENOG4106MP8 UPF0754 membrane protein HC660_10370 ENOG4105WZB UPF0342 protein HC660_10380 ENOG4105F1N DNA alkylation repair HC660_10400 ENOG4105D4P Coproporphyrinogen iii oxidase HC660_10410 ENOG4107S91 Sodium hydrogen exchanger HC660_10420 ENOG4105NCW Trka-c domain protein HC660_10440 ENOG4105CGU Enoyl-CoA hydratase HC660_10460 ENOG4108IUX (ABC) transporter HC660_10470 ENOG4105RHA ABC transporter, permease HC660_10480 ENOG4107VRP DNA repair exonuclease HC660_10490 ENOG4106D4I domain protein HC660_10500 ENOG4105EQI Metal Dependent Phosphohydrolase HC660_10520 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HC660_10580 ENOG4105NBU tryptophan transport protein HC660_10590 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HC660_10600 ENOG4105K59 histidine triad (HIT) protein HC660_10670 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HC660_10680 ENOG4105BZ4 penicillin-binding protein HC660_10690 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HC660_10700 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HC660_10710 ENOG4105C1Q protoporphyrinogen oxidase HC660_10730 ENOG4105ECB domain protein HC660_10750 ENOG41090T1 Membrane HC660_10760 ENOG4105DER m42 family HC660_10790 ENOG4106AXD HC660_10800 ENOG4108RQ5 Beta-lactamase domain-containing protein HC660_10810 ENOG4105DF9 Lipoate-protein, ligase HC660_10830 ENOG4105CEY Amp-dependent synthetase and ligase HC660_10850 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HC660_10860 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HC660_10870 ENOG4105KD7 acetyltransferase HC660_10890 ENOG4108HUF Transporter HC660_10900 ENOG4107TB6 phosphoglycerate mutase HC660_10920 ENOG4107F3J Amp-dependent synthetase and ligase HC660_10930 ENOG4107ZYJ bioY protein HC660_10940 ENOG4106YBV Methyl-accepting chemotaxis HC660_10980 ENOG4105XVF Competence transcription factor HC660_10990 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HC660_11000 ENOG4105X3H Excalibur domain protein HC660_11010 ENOG4105E1V na solute symporter HC660_11020 ENOG4106CAD Protein of unknown function (DUF3311) HC660_11030 ENOG41060YP HC660_11060 ENOG4107SCK Monooxygenase HC660_11070 ENOG4108INS Transcriptional regulator HC660_11100 ENOG4105TRI Hydrolase HC660_11130 ENOG4108KK1 membrane protein AbrB duplication HC660_11140 ENOG4106K7D Major facilitator family transporter HC660_11150 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HC660_11160 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding HC660_11190 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HC660_11210 ENOG4105EYH Exonuclease HC660_11310 ENOG4105ERH Fumarylacetoacetate hydrolase HC660_11330 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HC660_11350 ENOG4105CAQ asparagine synthetase HC660_11370 ENOG4105UQX Mate efflux family protein HC660_11380 ENOG4106HBX Transcriptional Regulator AraC Family HC660_11390 ENOG4105ETE Transcriptional regulator (LacI family HC660_11400 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HC660_11410 ENOG4105SF0 DinB family HC660_11420 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HC660_11430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HC660_11440 ENOG4105MYW Pentapeptide repeat protein HC660_11450 ENOG4107S9D Alpha beta hydrolase HC660_11460 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HC660_11470 ENOG4107RIQ Sulfate adenylate transferase HC660_11480 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HC660_11490 ENOG4108N5B 2-phosphosulfolactate phosphatase HC660_11500 ENOG41061P3 phosphosulfolactate synthase HC660_11520 ENOG4105DIA mandelate racemase muconate lactonizing HC660_11530 ENOG4107RCC Major Facilitator Superfamily HC660_11540 ENOG4108SZE gCN5-related N-acetyltransferase HC660_11550 ENOG4105MA6 gCN5-related N-acetyltransferase HC660_11570 ENOG4108VPT UPF0234 protein HC660_11580 ENOG4105QNR S1 RNA binding domain protein HC660_11620 ENOG4105K7K Transcriptional regulator HC660_11640 ENOG410751J HC660_11650 ENOG4105D4Y metalloprotease HC660_11660 ENOG4105EPR degv family HC660_11670 ENOG4107AYK membrAne HC660_11690 ENOG41073B9 HC660_11700 ENOG4108KP7 hydrolase HC660_11710 ENOG4108MXZ Esterase HC660_11720 ENOG4105VG1 fes assembly suf system protein HC660_11740 ENOG4105IQ5 FAD linked oxidase domain protein HC660_11760 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HC660_11770 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HC660_11790 ENOG4105C8Y Acetylornithine aminotransferase HC660_11800 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HC660_11820 ENOG4105DBV ornithine carbamoyltransferase HC660_11870 ENOG4107RMD Basic membrane lipoprotein HC660_11900 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HC660_11910 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HC660_11930 ENOG4105C3U ABC transporter HC660_11940 ENOG4108JQ7 (ABC) transporter HC660_11970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC660_11990 ENOG4105C31 Tryptophanyl-tRNA synthetase HC660_12000 ENOG4108J59 Extracellular solute-binding protein, family 5 HC660_12010 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HC660_12020 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC660_12040 ENOG4108JQ7 (ABC) transporter HC660_12070 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HC660_12080 ENOG4108ZCF integral membrane protein HC660_12090 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HC660_12110 ENOG4105DPN Oligoendopeptidase f HC660_12130 ENOG4105T58 Dithiol-disulfide isomerase HC660_12140 ENOG4108Z18 K06886 hemoglobin HC660_12150 ENOG4105E4C Lytic transglycosylase catalytic HC660_12160 ENOG4105MIX Adenylate cyclase HC660_12190 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HC660_12200 ENOG4105EMS pseudouridine synthase HC660_12230 ENOG4105ETU transcriptional activator (TenA HC660_12240 ENOG4108VEU Thiamine monophosphate synthase HC660_12270 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HC660_12280 ENOG4105D06 uba thif-type nad fad binding protein HC660_12290 ENOG4105DWF phosphomethylpyrimidine kinase HC660_12300 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HC660_12310 ENOG4107A88 HC660_12410 ENOG4105ENA helicase HC660_12440 ENOG4108ZMI UPF0477 protein HC660_12460 ENOG4105C28 cystathionine HC660_12470 ENOG4105C28 cystathionine HC660_12480 ENOG4105D9U N-acetyltransferase HC660_12490 ENOG4105JHY Membrane HC660_12520 ENOG4106BHF HC660_12620 ENOG41083Q9 chitosanase HC660_12640 ENOG4105G7B Protein of unknown function (DUF2992) HC660_12650 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family HC660_12670 ENOG4107TXC Transcriptional regulator HC660_12710 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HC660_12730 ENOG4108ZJ4 polysaccharide deacetylase HC660_12740 ENOG4107CUJ Protein of unknown function (DUF2690) HC660_12790 ENOG4108IEG Formate dehydrogenase Alpha subunit HC660_12830 ENOG4106A3M Cytochrome p-450 HC660_12840 ENOG41087PP glycosyltransferase MGT family HC660_12850 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HC660_12860 ENOG4105C4B ABC transporter, permease HC660_12870 ENOG4108IXI (ABC) transporter HC660_12890 ENOG4105Q95 Cupin 2, conserved barrel domain protein HC660_12920 ENOG4105D2H Uronic isomerase HC660_12930 ENOG4105CT4 transporter HC660_12940 ENOG4105DG4 malate L-lactate dehydrogenase HC660_12950 ENOG4105CPQ Dehydrogenase HC660_12960 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HC660_12970 ENOG4105DMW Dehydrogenase reductase HC660_12980 ENOG4108I5G Major Facilitator superfamily HC660_12990 ENOG4107KJX Transcriptional regulator HC660_13000 ENOG4107QZW Altronate oxidoreductase HC660_13010 ENOG4105CTX dehydratase HC660_13020 ENOG4107TSN permease HC660_13060 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HC660_13090 ENOG4105K7W phage-related replication protein HC660_13100 ENOG4105WEF catalase HC660_13110 ENOG410635T phage-like element pbsx protein HC660_13200 ENOG4108TFU terminase (Small subunit) HC660_13210 ENOG4105IG6 Phage terminase, large subunit HC660_13220 ENOG4108MDF Phage Portal Protein HC660_13270 ENOG41060SN HC660_13300 ENOG4105PQS phage protein HC660_13310 ENOG4105FR7 XkdM protein, phage-like element PBSX HC660_13320 ENOG4105MTC XkdN-like protein HC660_13340 ENOG4108FKH Transglycosylase SLT domain HC660_13340 ENOG4108FKH Transglycosylase SLT domain HC660_13340 ENOG4108FKH Transglycosylase SLT domain HC660_13350 ENOG4108WZM domain protein HC660_13360 ENOG4105X7F HC660_13380 ENOG4105MFU Protein of unknown function (DUF2634) HC660_13390 ENOG41066EA baseplate J family protein HC660_13400 ENOG410906S phage-like element pbsx protein xkdt HC660_13420 ENOG41068G1 HC660_13480 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HC660_13510 ENOG4105CJ3 phosphate transporter HC660_13520 ENOG4107GRR phosphate transport regulator HC660_13530 ENOG4107R7I amino acid HC660_13550 ENOG4105EDW glycosyl transferase, family 39 HC660_13560 ENOG4105CKK Glycosyl transferase, family 2 HC660_13570 ENOG4105C0H protease HC660_13590 ENOG4108ME1 Peptidase M55 D-aminopeptidase HC660_13600 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HC660_13610 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC660_13620 ENOG4105C3U ABC transporter HC660_13640 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HC660_13650 ENOG4105DTQ mandelate racemase muconate lactonizing HC660_13660 ENOG4107SN7 NLP P60 protein HC660_13670 ENOG4108JQ7 (ABC) transporter HC660_13680 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HC660_13690 ENOG4107TUM Amidinotransferase HC660_13700 ENOG4108S4H thioesterase Superfamily protein HC660_13710 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HC660_13750 ENOG4108428 Inherit from COG: -acetyltransferase HC660_13770 ENOG41080TC multidrug resistance protein HC660_13780 ENOG4105CIY formyltetrahydrofolate deformylase HC660_13790 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HC660_13820 ENOG4105K56 Transcriptional regulator HC660_13830 ENOG4108ZHJ Organic hydroperoxide resistance protein HC660_13840 ENOG4107TVC Glycosyl transferase, family 2 HC660_13850 ENOG4107Y2X deaminase HC660_13860 ENOG4105CVJ phosphoglycerate mutase HC660_13870 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HC660_13880 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HC660_13900 ENOG4108W7F transporter, permease HC660_13910 ENOG4108JJB ABC transporter HC660_13920 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HC660_13930 ENOG4108X43 YKOF domain protein HC660_13940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HC660_13950 ENOG41062D9 Histidine kinase HC660_13970 ENOG4106849 propeptide, pepSY amd peptidase M4 HC660_13980 ENOG4105CJW magnesium transporter HC660_13990 ENOG4105V75 Transcriptional regulator HC660_14080 ENOG4105DQE DNA ligase HC660_14090 ENOG4105FDF Could be involved in DNA repair (By similarity) HC660_14100 ENOG4105BZU Histidine kinase HC660_14110 ENOG4107T5V SNARE associated Golgi HC660_14120 ENOG4107TS3 membrane protein, TerC HC660_14130 ENOG4108WZW RNA polymerase sigma HC660_14150 ENOG410681C small acid-soluble spore protein HC660_14170 ENOG4105D0M Protease HtpX homolog HC660_14210 ENOG4108TGC Acyltransferase HC660_14220 ENOG4105BZU Histidine kinase HC660_14230 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HC660_14240 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HC660_14250 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HC660_14260 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HC660_14280 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit HC660_14290 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HC660_14300 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HC660_14310 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HC660_14350 ENOG4105BZU Histidine kinase HC660_14360 ENOG41090MY MarR family Transcriptional regulator HC660_14370 ENOG4105ER2 Ompa motb domain protein HC660_14380 ENOG4105E14 MotA TolQ exbB proton channel HC660_14400 ENOG4108K88 Membrane HC660_14410 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HC660_14420 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase HC660_14430 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HC660_14440 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HC660_14480 ENOG4105F0V Cell wall hydrolase HC660_14510 ENOG4105C59 p-type ATPase HC660_14520 ENOG4105DC7 peptidase M24 HC660_14540 ENOG4105CID antiterminator HC660_14560 ENOG4105KRI phosphocarrier protein (HPr HC660_14570 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HC660_14590 ENOG4105F6S Spore photoproduct lyase HC660_14610 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HC660_14620 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HC660_14630 ENOG4105K4I Scp-like extracellular HC660_14650 ENOG4105BZU Histidine kinase HC660_14660 ENOG4105CHM Aminotransferase HC660_14680 ENOG4107R88 Chemotaxis protein (CheV) HC660_14690 ENOG4105UIN HC660_14710 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HC660_14730 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HC660_14740 ENOG4105EPM Diguanylate phosphodiesterase HC660_14760 ENOG4107IN1 Protein of unknown function (DUF1797) HC660_14770 ENOG4108XRC Protein of unknown function (DUF458) HC660_14830 ENOG4105NQC Flavodoxin HC660_14850 ENOG4105CH2 amidohydrolase HC660_14870 ENOG4105D8X mechanosensitive ion channel HC660_14880 ENOG4105D3R alkyl hydroperoxide reductase HC660_14890 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HC660_14920 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HC660_14930 ENOG4105D06 uba thif-type nad fad binding protein HC660_14940 ENOG4105CVM Molybdenum cofactor synthesis domain protein HC660_14950 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HC660_14960 ENOG4108ZAF Molybdopterin HC660_14970 ENOG41067WU Molybdopterin converting factor (Subunit 1) HC660_14980 ENOG4105BZ1 (ABC) transporter HC660_14990 ENOG4105BZ1 (ABC) transporter HC660_15010 ENOG4107X8C Efflux transporter RND family MFP subunit HC660_15020 ENOG4105C19 ABC transporter HC660_15030 ENOG4107RBB ABC transporter, permease HC660_15040 ENOG4105E98 transcriptional regulator DeoR family HC660_15050 ENOG4105DE4 1-phosphofructokinase HC660_15060 ENOG4105DM4 PTS System HC660_15070 ENOG4105C3F Signal peptidase i HC660_15090 ENOG4105C5H ABC transporter HC660_15100 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HC660_15140 ENOG4105BZU Histidine kinase HC660_15160 ENOG4107ZYR domain protein HC660_15180 ENOG4105CN5 Metallo-Beta-Lactamase HC660_15200 ENOG4108X4Q Hydrolase HC660_15210 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HC660_15240 ENOG4105CPP Dehydrogenase, E1 component HC660_15250 ENOG4105C7S Dehydrogenase HC660_15260 ENOG4107QN2 dihydrolipoyl dehydrogenase HC660_15280 ENOG4105CXN decarboxylase HC660_15290 ENOG4105WBI UPF0223 protein HC660_15320 ENOG4105ECY inositol monophosphatase HC660_15340 ENOG4105JQZ Methyltransferase HC660_15420 ENOG4105CI3 gtp-binding protein typa HC660_15430 ENOG4105QA2 HC660_15460 ENOG4108IAB Phoh family HC660_15480 ENOG4105CSV Glutaminase HC660_15490 ENOG4105ZPI UPF0358 protein HC660_15500 ENOG4105CNI cell division protein FtsW HC660_15510 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HC660_15530 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HC660_15550 ENOG4105BZ9 Cytochrome C oxidase, subunit I HC660_15560 ENOG4105CCU oxidase (Subunit III) HC660_15570 ENOG41064X9 cytochrome C oxidase subunit IV HC660_15600 ENOG41080XQ Signal transduction protein with cbs domains HC660_15610 ENOG4106UY4 Inherit from COG: Scp-like extracellular HC660_15650 ENOG4105WUC UPF0298 protein HC660_15660 ENOG4106H78 methyltransferase HC660_15670 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HC660_15680 ENOG4105H20 Sporulation integral membrane protein YlbJ HC660_15690 ENOG4105D78 K07001 NTE family protein HC660_15700 ENOG41063PX domain protein HC660_15710 ENOG4105CDE UPF0348 protein HC660_15720 ENOG4105KNH Nucleic acid-binding protein HC660_15780 ENOG4108V6E Cell division protein mraZ HC660_15790 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HC660_15810 ENOG4105CJN penicillin-binding protein HC660_15820 ENOG4105CJN penicillin-binding protein HC660_15830 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HC660_15840 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HC660_15850 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HC660_15860 ENOG4105CNI cell division protein FtsW HC660_15870 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HC660_15880 ENOG4105D4A Cell wall formation (By similarity) HC660_15890 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HC660_15900 ENOG4108R2U division initiation protein HC660_15920 ENOG4105K67 small basic protein HC660_15930 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HC660_15940 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HC660_15960 ENOG4105FFI sigma-e processing peptidase spoiiga HC660_15970 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC660_15990 ENOG4105DKW ABC transporter HC660_16010 ENOG4105WR5 sporulation protein, YlmC YmxH family HC660_16020 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HC660_16030 ENOG4105DFA alanine racemase domain protein HC660_16040 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HC660_16050 ENOG41067XK integral membrane protein HC660_16060 ENOG4105DBK s4 domain protein HC660_16080 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HC660_16100 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HC660_16110 ENOG4105C34 Pseudouridine synthase HC660_16120 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HC660_16140 ENOG4105CXT aspartate transcarbamylase HC660_16160 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HC660_16170 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HC660_16180 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HC660_16190 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HC660_16200 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HC660_16210 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HC660_16220 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HC660_16240 ENOG4107S4M Sulfate adenylate transferase HC660_16250 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HC660_16260 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HC660_16270 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HC660_16280 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HC660_16310 ENOG4105DSJ YicC domain protein HC660_16320 ENOG4105KC4 UPF0296 protein HC660_16330 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HC660_16350 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HC660_16360 ENOG4105C25 Primosomal protein n' HC660_16370 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HC660_16380 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HC660_16390 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HC660_16400 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HC660_16410 ENOG4108ZF3 Phosphatase HC660_16420 ENOG4105D9P serine threonine protein kinase HC660_16430 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HC660_16440 ENOG4105DJV ribulose-phosphate 3-epimerase HC660_16450 ENOG4105FJ0 thiamine HC660_16460 ENOG4105VB9 50S ribosomal protein l28 HC660_16470 ENOG4108ZAA Alkaline-shock protein HC660_16480 ENOG4105DP4 dak2 domain fusion protein ylov HC660_16500 ENOG4105EJQ L-serine dehydratase HC660_16510 ENOG4105CB5 ATP-dependent DNA helicase recG HC660_16520 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HC660_16540 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HC660_16550 ENOG4105CHR reductase HC660_16570 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HC660_16580 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HC660_16590 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HC660_16610 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HC660_16630 ENOG4105K5M 30s ribosomal protein S16 HC660_16640 ENOG4108BW8 UPF0109 protein HC660_16660 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HC660_16670 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HC660_16680 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HC660_16690 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HC660_16700 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HC660_16720 ENOG4105VM1 flagellar HC660_16730 ENOG4105CMV Succinyl-CoA synthetase subunit beta HC660_16740 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HC660_16750 ENOG4105C79 DNA protecting protein DprA HC660_16760 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HC660_16770 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HC660_16780 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HC660_16790 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HC660_16800 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HC660_16820 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HC660_16830 ENOG4108ZC9 flagellar basal-body rod protein flgc HC660_16840 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HC660_16850 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HC660_16860 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HC660_16890 ENOG4106YF4 Flagellar biosynthesis chaperone HC660_16910 ENOG410696Y Flagellar hook-length control protein HC660_16920 ENOG410822I Flagellar hook capping protein HC660_16930 ENOG4108JQA flagellar HC660_16940 ENOG41068WV flagellar FlbD family protein HC660_16960 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HC660_16970 ENOG4105DD5 Flagellar motor switch protein HC660_16980 ENOG4107YTP response regulator receiver protein HC660_17000 ENOG4105CN7 Flagellar biosynthetic protein FliP HC660_17010 ENOG4105VS8 Flagellar biosynthetic protein fliq HC660_17020 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HC660_17030 ENOG4105D00 flagellar biosynthetic protein flhB HC660_17040 ENOG4105D7B Flagellar biosynthesis protein flha HC660_17050 ENOG4105FZW flagellar biosynthesis regulator FlhF HC660_17070 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HC660_17080 ENOG4105CBS Chea signal transduction histidine kinase HC660_17090 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HC660_17120 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC660_17140 ENOG4105CE9 30S ribosomal protein S2 HC660_17150 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HC660_17170 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HC660_17180 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HC660_17190 ENOG4105KNE Phosphatidate cytidylyltransferase HC660_17210 ENOG4105DZP Membrane-associated zinc metalloprotease HC660_17220 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HC660_17230 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HC660_17240 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HC660_17250 ENOG4105CHV Transcription elongation factor NusA HC660_17260 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HC660_17270 ENOG4105VHM ribosomal protein HC660_17280 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HC660_17290 ENOG4105W7A Protein of unknown function (DUF503) HC660_17300 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HC660_17310 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HC660_17320 ENOG4105DTN riboflavin biosynthesis protein ribF HC660_17330 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HC660_17340 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HC660_17360 ENOG4105C1V Peptidase, M16 HC660_17380 ENOG4105E35 Dipicolinate synthase subunit A HC660_17390 ENOG4108S0H Dipicolinic acid synthetase, b subunit HC660_17400 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HC660_17420 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HC660_17440 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HC660_17460 ENOG4105CNU cell division protein FtsK HC660_17470 ENOG4105FDP GntR family transcriptional regulator HC660_17510 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HC660_17520 ENOG4105XZV Protein of unknown function (DUF3243) HC660_17550 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HC660_17560 ENOG4105CEV competence damage-inducible protein HC660_17580 ENOG4108A04 Beta-lactamase HC660_17590 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HC660_17600 ENOG4105D48 metallophosphoesterase HC660_17610 ENOG4105MCT stage V sporulation protein S HC660_17630 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HC660_17640 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HC660_17670 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HC660_17680 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HC660_17790 ENOG4106BHF HC660_17820 ENOG4105IIP Membrane HC660_17830 ENOG4105W1N transcriptional regulator HC660_17850 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HC660_17860 ENOG4105K7W phage-related replication protein HC660_17870 ENOG4108X3M OsmC Ohr family protein HC660_17920 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HC660_17930 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HC660_17970 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HC660_17980 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HC660_17990 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HC660_18000 ENOG4105U6W MutT NUDIX family protein HC660_18010 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HC660_18020 ENOG4106F1P AAA ATPase, central domain protein HC660_18030 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HC660_18040 ENOG4105CXI aluminum resistance protein HC660_18050 ENOG4105KV4 Transcriptional regulator HC660_18060 ENOG4105C5F glutamine synthetase HC660_18090 ENOG4105UA4 acetyltransferase HC660_18120 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HC660_18140 ENOG4108RZ2 Glycoside hydrolase family 16 HC660_18160 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HC660_18170 ENOG41073R8 VanW family HC660_18180 ENOG4105NX3 Membrane HC660_18190 ENOG4105VMP Transcriptional regulator HC660_18210 ENOG4108RAV Conserved protein HC660_18300 ENOG4105FVX HC660_18320 ENOG4105K7W phage-related replication protein HC660_18360 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HC660_18380 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HC660_18400 ENOG4108SVB resolvase HC660_18410 ENOG4105VPS UPF0291 protein HC660_18420 ENOG4105CV1 Transketolase (EC 2.2.1.1) HC660_18460 ENOG4107QIV Cytochrome c biogenesis protein HC660_18510 ENOG4107DZX Small, acid-soluble spore protein P HC660_18530 ENOG4108I0Z Aconitate hydratase HC660_18540 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HC660_18560 ENOG41067CD Small, acid-soluble spore protein Tlp HC660_18580 ENOG4105MI2 HC660_18590 ENOG4105W8X HesB YadR YfhF-family protein HC660_18600 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HC660_18610 ENOG4105K4P CoA-binding domain protein HC660_18620 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HC660_18660 ENOG4107QWR cellulase (EC 3.2.1.4) HC660_18690 ENOG4108KXV response regulator HC660_18710 ENOG4107SYN Glycosyl hydrolases family 43 HC660_18730 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HC660_18740 ENOG4107T5V SNARE associated Golgi HC660_18760 ENOG4107QX3 carboxylase HC660_18770 ENOG4105E39 Enoyl-CoA hydratase HC660_18780 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HC660_18790 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HC660_18800 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HC660_18810 ENOG4105CEY Amp-dependent synthetase and ligase HC660_18820 ENOG4105C1G acyl-Coa dehydrogenase HC660_18850 ENOG4105F32 YngK protein HC660_18860 ENOG4106U2H Protein of unknown function (DUF1360) HC660_18880 ENOG4105CEY Amp-dependent synthetase and ligase HC660_18890 ENOG4105C0W non-ribosomal peptide synthetase HC660_18910 ENOG4105C0W non-ribosomal peptide synthetase HC660_18920 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HC660_18930 ENOG4108N2V aldose 1-epimerase HC660_18940 ENOG4107QJQ Mate efflux family protein HC660_18990 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HC660_19000 ENOG4105SKE transcriptional Regulator LysR family HC660_19010 ENOG4105CB2 alcohol dehydrogenase HC660_19020 ENOG4105BZ8 glutamate synthase HC660_19030 ENOG4105CBC glutamate synthase HC660_19040 ENOG4105C5Q Transcriptional regulator HC660_19050 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HC660_19110 ENOG4108UB7 HC660_19120 ENOG41068WN HC660_19150 ENOG4105CJ1 ABC, transporter HC660_19170 ENOG4105IE8 Alpha-ketoglutarate permease HC660_19180 ENOG4107U6E carbohydrate kinase FGGY HC660_19190 ENOG4108M3J Dehydrogenase HC660_19200 ENOG4108J2R molybdopterin oxidoreductase HC660_19220 ENOG4108YQE rare lipoprotein a HC660_19230 ENOG4105XPP Protein of unknown function (DUF1275) HC660_19240 ENOG4108NR7 pectate lyase HC660_19250 ENOG4105CHR reductase HC660_19310 ENOG4105C54 Major Facilitator superfamily HC660_19320 ENOG4107Y9E nuclease HC660_19350 ENOG4105CMG Carbohydrate kinase HC660_19380 ENOG4105DSG hydrolase family 43 HC660_19390 ENOG4105CT4 transporter HC660_19430 ENOG4108M1A Chitin-binding protein HC660_19450 ENOG4107T94 Endo-14-beta-xylanase HC660_19550 ENOG4107NTZ HC660_19570 ENOG410780I phosphoprotein phosphatase activity HC660_19590 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HC660_19600 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HC660_19640 ENOG4106BHF HC660_19690 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HC660_19710 ENOG4108Z7R Chaperone CsaA HC660_19720 ENOG4105FTV AraC Family Transcriptional Regulator HC660_19730 ENOG4108HJF gCN5-related N-acetyltransferase HC660_19750 ENOG4108W8B Beta-lactamase domain protein HC660_19770 ENOG4105D29 Helix-turn-helix type 11 domain protein HC660_19790 ENOG4105KTU Transcriptional regulator, arsr family HC660_19810 ENOG4108SJC Membrane HC660_19850 ENOG4105ECK Fatty Acid Desaturase HC660_19860 ENOG4108ZGX Histidine kinase HC660_19870 ENOG4108S01 response regulator HC660_19880 ENOG41069ER domain protein HC660_19890 ENOG4105C9U ATP-dependent DNA helicase RecQ HC660_19900 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HC660_19910 ENOG4105SCY DNAK suppressor HC660_19940 ENOG4105C26 Dehydrogenase HC660_19950 ENOG4105EWU Squalene--hopene cyclase HC660_19960 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HC660_19970 ENOG4105C8J )-transporter HC660_19980 ENOG4105C09 Bile acid HC660_19990 ENOG4105C7S Dehydrogenase HC660_20010 ENOG4107T89 von Willebrand factor, type A HC660_20020 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HC660_20040 ENOG4105K4H Nlp p60 protein HC660_20050 ENOG41087PP glycosyltransferase MGT family HC660_20070 ENOG4107QMU Mate efflux family protein HC660_20080 ENOG4106SCS STAS domain HC660_20120 ENOG4105FR1 rard protein HC660_20150 ENOG4105C6Z Gluconate HC660_20150 ENOG4105C6Z Gluconate HC660_20160 ENOG41090U3 tautomerase HC660_20200 ENOG4105FBA Phospholipase Carboxylesterase HC660_20230 ENOG4105E1V na solute symporter HC660_20270 ENOG4108VXD carboxy-peptidase HC660_20280 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HC660_20290 ENOG4106Z5R HC660_20300 ENOG410841Q phosphoesterase PA-phosphatase related protein HC660_20350 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HC660_20360 ENOG4108TSC N-acetyltransferase HC660_20370 ENOG4107S4Y M20 DapE family protein YgeY HC660_20400 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HC660_20460 ENOG4107T32 3-phytase (EC 3.1.3.8) HC660_20470 ENOG4105E0X reductase HC660_20480 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HC660_20520 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) HC660_20530 ENOG41090WU lipolytic protein G-D-S-L family HC660_20540 ENOG4108KF3 Electron transport protein SCO1 SenC HC660_20560 ENOG4105C7B Threonine dehydratase HC660_20580 ENOG4108UT2 hemolysin iii HC660_20600 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HC660_20640 ENOG4107YX5 Pfam:DUF548 HC660_20650 ENOG4108Y6J UPF0403 protein HC660_20660 ENOG4105C01 Dihydroxy-acid dehydratase HC660_20690 ENOG4108V06 Glutathione peroxidase HC660_20700 ENOG4105CVG Homoserine O-transsuccinylase HC660_20780 ENOG41081VK Ribonuclease HC660_20820 ENOG410890F Dynamin family HC660_20840 ENOG41065KQ synthase HC660_20850 ENOG4105C2W permease HC660_20860 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HC660_20870 ENOG4105CTD carboxy-peptidase HC660_20880 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HC660_20890 ENOG4108UHU Aldolase HC660_20900 ENOG4105D7K pfkb domain protein HC660_20910 ENOG4108M60 Transcriptional regulator HC660_20930 ENOG4105CHR reductase HC660_20940 ENOG4105DVT helicase HC660_20970 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HC660_20980 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) HC660_20990 ENOG4108UKS UPF0398 protein HC660_21010 ENOG4107X2U Inherit from COG: Exonuclease-like protein HC660_21020 ENOG4108I5C dEAD DEAH box helicase HC660_21120 ENOG4105BZ4 penicillin-binding protein HC660_21140 ENOG4105CSM endonuclease III HC660_21160 ENOG4105C5S asparaginyl-tRNA synthetase HC660_21170 ENOG4105CHM Aminotransferase HC660_21190 ENOG4105YAC HC660_21200 ENOG4105DVT helicase HC660_21210 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HC660_21220 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HC660_21230 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HC660_21240 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HC660_21250 ENOG4105DJ0 Poly(A) Polymerase HC660_21260 ENOG4105CPK Glycosyl transferase (Group 1 HC660_21270 ENOG4105FJR Lmbe family HC660_21280 ENOG4108Z5K methylglyoxal synthase HC660_21290 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HC660_21300 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HC660_21310 ENOG4108JYZ YitT family HC660_21350 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HC660_21390 ENOG41068YB TPR repeat-containing protein HC660_21400 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HC660_21420 ENOG4105CIH Imidazole acetol-phosphate transaminase HC660_21440 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HC660_21450 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HC660_21470 ENOG4108I0Q anthranilate phosphoribosyltransferase HC660_21480 ENOG4105CRQ synthase (Component I) HC660_21490 ENOG4105KHN chorismate mutase HC660_21500 ENOG4105D49 3-dehydroquinate synthase HC660_21510 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HC660_21520 ENOG4105BZU Histidine kinase HC660_21530 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HC660_21540 ENOG4105EAH synthase HC660_21550 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HC660_21560 ENOG4105XXQ heptaprenyl diphosphate synthase component I HC660_21580 ENOG4105EUJ GTP cyclohydrolase i HC660_21590 ENOG4105K70 DNA-binding protein HC660_21600 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HC660_21630 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HC660_21640 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HC660_21650 ENOG41065D1 HC660_21660 ENOG4105S2F HC660_21680 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HC660_21690 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HC660_21700 ENOG4105CAT Cytidine monophosphate kinase HC660_21730 ENOG4105MSI germination protein ypeb HC660_21750 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HC660_21760 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HC660_21790 ENOG4107RGJ metallophosphoesterase HC660_21820 ENOG4105I7S Abortive infection protein HC660_21830 ENOG4105C9U ATP-dependent DNA helicase RecQ HC660_21840 ENOG4105T7X HC660_21860 ENOG4108SAX Membrane HC660_21870 ENOG4108JQ1 Dehydrogenase HC660_21880 ENOG4105FF2 Type I DHQase HC660_21910 ENOG4105BZU Histidine kinase HC660_21920 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HC660_21930 ENOG4105CRE cytochrome C HC660_21940 ENOG4107TWT Cytochrome c biogenesis protein HC660_21960 ENOG4105FE9 pseudouridine synthase HC660_21980 ENOG4108JIC nucleoside recognition domain protein HC660_21990 ENOG4105DZ1 carboxypeptidase HC660_22010 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HC660_22020 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HC660_22050 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HC660_22060 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HC660_22070 ENOG4108R6K riboflavin synthase, subunit alpha HC660_22080 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HC660_22100 ENOG4105C3F Signal peptidase i HC660_22110 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) HC660_22120 ENOG4107ZE5 PPIases accelerate the folding of proteins HC660_22130 ENOG4105PTM secreted protein HC660_22140 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HC660_22160 ENOG4105G6R Stage v sporulation protein ae HC660_22180 ENOG4105CZ3 stage V sporulation protein ad HC660_22190 ENOG41090VF Stage v sporulation protein ac HC660_22220 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC660_22230 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HC660_22240 ENOG41082AN stage II sporulation protein HC660_22250 ENOG4105DZ1 carboxypeptidase HC660_22260 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HC660_22270 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HC660_22280 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HC660_22300 ENOG4105I3K Ferric uptake regulator, Fur family HC660_22310 ENOG4105MZ9 stage II sporulation protein m HC660_22340 ENOG4105DFD Na H antiporter HC660_22350 ENOG4108IJ0 Aspartate ammonia-lyase HC660_22360 ENOG4105HDK L-asparaginase HC660_22370 ENOG4108IMY Transcriptional regulator HC660_22390 ENOG4108YZ4 nudix hydrolase HC660_22400 ENOG4105CPC Aldo Keto reductase HC660_22440 ENOG4106HZJ HC660_22450 ENOG4105RHY Pfam:UPF0157 HC660_22460 ENOG4105KAC Antibiotic biosynthesis monooxygenase HC660_22470 ENOG4108XET gCN5-related N-acetyltransferase HC660_22490 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HC660_22510 ENOG4105E5W Transporter HC660_22530 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HC660_22560 ENOG4108IXY short-chain dehydrogenase reductase HC660_22570 ENOG41069FQ Metallo-beta-lactamase superfamily HC660_22580 ENOG4105II7 pyrroline-5-carboxylate reductase HC660_22600 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HC660_22620 ENOG410861F 50S ribosomal protein L33 HC660_22630 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HC660_22640 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HC660_22660 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HC660_22670 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HC660_22690 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) HC660_22700 ENOG4108NA0 Uncharacterized conserved protein (COG2071) HC660_22710 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HC660_22720 ENOG4108HNZ carboxyl transferase HC660_22730 ENOG4108ZVT methylmalonyl-coA epimerase HC660_22740 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HC660_22750 ENOG4108QEG Membrane HC660_22760 ENOG4105CDA abc transporter atp-binding protein HC660_22770 ENOG4105E5Q amino acid AbC transporter HC660_22780 ENOG4108HW3 (ABC) transporter HC660_22790 ENOG4108Y6J UPF0403 protein HC660_22800 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HC660_22830 ENOG4105C7S Dehydrogenase HC660_22840 ENOG4105CPP Dehydrogenase, E1 component HC660_22870 ENOG4105CKM Branched-chain carboxylic acid kinase HC660_22880 ENOG4107RDP Dehydrogenase HC660_22900 ENOG4108JUB Transcriptional regulator HC660_22910 ENOG4106CCJ Protein of unknown function (DUF2627) HC660_22920 ENOG4105CR4 methylisocitrate lyase HC660_22930 ENOG4105DXD 2-methylcitrate dehydratase HC660_22950 ENOG4105C1G acyl-Coa dehydrogenase HC660_22960 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HC660_22980 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HC660_22990 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HC660_23010 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HC660_23020 ENOG4107QQR Sporulation HC660_23030 ENOG4105S1Z Stage IV sporulation protein B HC660_23040 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HC660_23050 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HC660_23060 ENOG4105DX0 Hemolysin A HC660_23080 ENOG4105CTB Polyprenyl synthetase HC660_23090 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HC660_23100 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HC660_23110 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HC660_23120 ENOG4105M7K Involved in the transcription termination process (By similarity) HC660_23130 ENOG4108ZSR alkaline shock protein HC660_23140 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HC660_23180 ENOG410644B Stage III sporulation protein af HC660_23200 ENOG4105KQ4 Stage iii sporulation protein ad HC660_23210 ENOG4108CQH stage III sporulation protein AC HC660_23220 ENOG4105KR5 Stage iii sporulation protein HC660_23230 ENOG4105CD2 stage iii sporulation protein aa HC660_23250 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HC660_23260 ENOG4105DC7 peptidase M24 HC660_23270 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HC660_23290 ENOG4105CBJ Metal-dependent enzyme HC660_23320 ENOG4105KST dependent repressor HC660_23330 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HC660_23340 ENOG4105WZW rhodanese family HC660_23350 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HC660_23360 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HC660_23370 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HC660_23380 ENOG4105C0D helicase HC660_23410 ENOG4108IMY Transcriptional regulator HC660_23430 ENOG4105VFR signal peptidase HC660_23540 ENOG41080XP Cbs domain HC660_23560 ENOG4105C37 (CBS) domain HC660_23610 ENOG4105C5X domain protein HC660_23660 ENOG4105E0M Sulfatase HC660_23690 ENOG4107ZXI Rhomboid family HC660_23710 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HC660_23760 ENOG41068DG YceG-like family HC660_23770 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HC660_23780 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HC660_23790 ENOG4105E2Z phosphate ABC transporter (Permease HC660_23800 ENOG4105C8U phosphate abc transporter HC660_23810 ENOG4105CVA phosphate HC660_23820 ENOG4107RF6 penicillin-binding protein HC660_23840 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HC660_23850 ENOG4105SXS Protein of unknown function (DUF456) HC660_23880 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HC660_23890 ENOG41063Y9 HC660_23900 ENOG4108U5J '-nucleotidase HC660_23910 ENOG4105N80 Ferric uptake regulator, Fur family HC660_23920 ENOG4108JYZ YitT family HC660_23930 ENOG41069ZM Protein of unknown function (DUF2624) HC660_23940 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HC660_23970 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HC660_23980 ENOG4105EGD dinuclear metal center protein, YbgI family HC660_24010 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC660_24020 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HC660_24030 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 HC660_24040 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HC660_24060 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HC660_24070 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HC660_24080 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HC660_24090 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HC660_24100 ENOG4105KG3 cytidine deaminase HC660_24120 ENOG4107YR5 Diacylglycerol kinase HC660_24130 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HC660_24140 ENOG4105CTJ Metal Dependent Phosphohydrolase HC660_24150 ENOG4105C9A Phoh family HC660_24160 ENOG4105EI1 sporulation protein yqfd HC660_24170 ENOG41068P3 sporulation protein YqfC HC660_24190 ENOG4105DI5 UPF0365 protein HC660_24200 ENOG4105F7J membrane-bound serine protease HC660_24210 ENOG4105KTH gatB Yqey HC660_24240 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HC660_24250 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HC660_24260 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HC660_24270 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HC660_24280 ENOG4105CFG Acts as a chaperone (By similarity) HC660_24290 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HC660_24300 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HC660_24310 ENOG4105CSA Coproporphyrinogen iii oxidase HC660_24320 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HC660_24340 ENOG4108ZRV stage ii sporulation protein p HC660_24350 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) HC660_24360 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HC660_24370 ENOG4105TQK DNA polymerase iii, delta' subunit HC660_24380 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HC660_24390 ENOG4108UK2 deaminase HC660_24400 ENOG4105KQC Competence protein HC660_24420 ENOG4108D32 Methyltransferase HC660_24440 ENOG4108WF2 Metal Dependent Phosphohydrolase HC660_24450 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HC660_24460 ENOG410812S Rna-binding protein HC660_24470 ENOG4105E2X shikimate dehydrogenase HC660_24480 ENOG4105CQW ribosome biogenesis GTPase YqeH HC660_24490 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HC660_24510 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HC660_24520 ENOG41080BT SNARE associated Golgi HC660_24550 ENOG4105WFK nuclease HC660_24560 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC660_24570 ENOG4107Y5K Resolvase HC660_24580 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HC660_24610 ENOG41087NI Sulfite exporter TauE/SafE HC660_24620 ENOG4105VFE sira family HC660_24630 ENOG4107TPS domain protein HC660_24650 ENOG4105VFE sira family HC660_24660 ENOG4105C72 UPF0176 protein HC660_24670 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HC660_24680 ENOG4105XTG Pfam:DUF156 HC660_24710 ENOG4105FTQ Dna gyrase HC660_24740 ENOG4105C9Q fumarate hydratase class II HC660_24750 ENOG4107RSM transcriptional regulator HC660_24760 ENOG4105EA8 2-Nitropropane dioxygenase HC660_24770 ENOG4105K56 Transcriptional regulator HC660_24840 ENOG4105ST3 Transcriptional regulator HC660_24890 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HC660_24900 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HC660_24910 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HC660_24920 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HC660_24940 ENOG4108JQ7 (ABC) transporter HC660_24960 ENOG4108MEK Metal-binding protein YodA HC660_24970 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HC660_24980 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HC660_25020 ENOG4105KRI phosphocarrier protein (HPr HC660_25030 ENOG4105VUF Transcriptional regulator HC660_25040 ENOG4105DQ4 alcohol dehydrogenase HC660_25050 ENOG4108Z0Z intracellular protease Pfpi family HC660_25060 ENOG4108HKT sucrose-6-phosphate hydrolase HC660_25070 ENOG4105F3R pts system mannose fructose sorbose family iid HC660_25080 ENOG4105ETZ PTS System HC660_25090 ENOG4108IQ3 PTS system HC660_25100 ENOG4105YHU PTS system HC660_25110 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HC660_25120 ENOG4105C85 amino acid HC660_25130 ENOG4105N14 lysine exporter protein LysE YggA HC660_25140 ENOG4108NGU Transcriptional regulator HC660_25150 ENOG4105JVQ RNA Polymerase HC660_25160 ENOG4108P49 AntiSigma factor HC660_25170 ENOG4105EXC Acyl-transferase HC660_25180 ENOG4105WDR HC660_25190 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HC660_25200 ENOG41082JN Transcriptional regulator HC660_25230 ENOG4105TMB Formate nitrite transporter HC660_25240 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HC660_25250 ENOG4108JB9 formate dehydrogenase HC660_25280 ENOG4105C28 cystathionine HC660_25310 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HC660_25340 ENOG4107XRG penicillin-binding protein HC660_25350 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HC660_25360 ENOG4105DBI uridine monophosphokinase HC660_25370 ENOG4105CFP Peptidase U32 HC660_25380 ENOG4105XYU peptidase (U32 family) HC660_25400 ENOG4105HHA aminodeoxychorismate lyase HC660_25410 ENOG4105VPH UPF0473 protein HC660_25420 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HC660_25430 ENOG4105VBH UPF0297 protein HC660_25440 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HC660_25450 ENOG4105C02 permease HC660_25460 ENOG41060CR HC660_25480 ENOG4105C7H Helicase, RecD TraA family HC660_25500 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HC660_25510 ENOG4105C3J Cysteine desulfurase HC660_25530 ENOG4105D1H recombination factor protein RarA HC660_25540 ENOG4105CUZ uba thif-type nad fad binding protein HC660_25560 ENOG4105C9M aspartyl-trna synthetase HC660_25570 ENOG4105CUT histidyl-tRNA synthetase HC660_25590 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HC660_25600 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HC660_25610 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HC660_25620 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HC660_25630 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HC660_25640 ENOG41067VP Protein of unknown function (DUF1049) HC660_25650 ENOG4105NCW Trka-c domain protein HC660_25660 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HC660_25680 ENOG4105CKP Polysaccharide Biosynthesis Protein HC660_25690 ENOG4108QG2 Membrane HC660_25700 ENOG4105NAP HC660_25710 ENOG4105VIE preprotein translocase, subunit YajC HC660_25720 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HC660_25730 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HC660_25740 ENOG41061AI Protein of unknown function (DUF2905) HC660_25750 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HC660_25760 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HC660_25780 ENOG4105IE8 Alpha-ketoglutarate permease HC660_25790 ENOG4105CK5 oxidoreductase HC660_25820 ENOG4105BZG amino acid carrier protein HC660_25830 ENOG4105CDY transcriptional regulatory protein HC660_25850 ENOG4106678 morphogenetic protein associated with SpoVID HC660_25860 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HC660_25870 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HC660_25880 ENOG4108IYU L-aspartate oxidase HC660_25910 ENOG4105CQC Prephenate dehydratase HC660_25920 ENOG41090I5 UPF0735 ACT domain-containing protein HC660_25930 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HC660_25950 ENOG4105K46 50S ribosomal protein l27 HC660_25960 ENOG4105X36 (ribosomal) protein HC660_25970 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HC660_26000 ENOG4107QMS site-determining protein HC660_26010 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HC660_26020 ENOG4105YHC Rod shape-determining protein MreD HC660_26040 ENOG4105DFF Rod shape-determining protein mreb HC660_26050 ENOG4105W5Q DNA repair protein (RadC HC660_26060 ENOG4108Z03 MAF-like protein HC660_26080 ENOG4106A3R peptidase HC660_26090 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HC660_26100 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HC660_26120 ENOG4106AR7 Spore coat protein HC660_26130 ENOG41068KH stage VI sporulation protein D HC660_26140 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HC660_26150 ENOG4105D52 delta-aminolevulinic acid dehydratase HC660_26170 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HC660_26190 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HC660_26210 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HC660_26220 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HC660_26230 ENOG4108IUQ atp-dependent protease HC660_26240 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HC660_26250 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HC660_26270 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HC660_26280 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HC660_26290 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HC660_26300 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HC660_26310 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HC660_26320 ENOG4108ZP8 Acetolactate synthase small subunit HC660_26330 ENOG4105C7K acetolactate synthase HC660_26350 ENOG4105I4A GCN5-related N-acetyltransferase HC660_26360 ENOG4107KM7 Heat induced stress protein YflT HC660_26400 ENOG4107QZI cell division protein FtsK HC660_26440 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HC660_26460 ENOG41068G1 HC660_26470 ENOG410651K Teichoic acid biosynthesis protein C HC660_26490 ENOG4108FKH Transglycosylase SLT domain HC660_26570 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HC660_26650 ENOG4107QRS glycosyltransferase group 2 family protein HC660_26660 ENOG4105K7W phage-related replication protein HC660_26730 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the HC660_26790 ENOG41069ER domain protein HC660_26800 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HC660_26830 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HC660_26840 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HC660_26860 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HC660_26900 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HC660_26920 ENOG4105C2M dna polymerase I HC660_27130 ENOG4105M59 Phosphodiesterase, mj0936 family HC660_27140 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HC660_27150 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HC660_27160 ENOG4108XJQ germination protein HC660_27170 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HC660_27180 ENOG41067TZ transcriptional regulator, MarR family HC660_27190 ENOG4105PFC Transcriptional regulator HC660_27210 ENOG4105E33 succinate dehydrogenase HC660_27230 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HC660_27250 ENOG4105CFH Aspartokinase HC660_27260 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HC660_27270 ENOG4105K63 Thioredoxin HC660_27280 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HC660_27290 ENOG4105C10 Electron transfer flavoprotein HC660_27300 ENOG4105BZJ Electron transfer flavoprotein HC660_27310 ENOG41060WC Enoyl-CoA hydratase HC660_27320 ENOG4107Z3H Transcriptional regulator, TetR family HC660_27330 ENOG4105CEY Amp-dependent synthetase and ligase HC660_27350 ENOG4105C98 muts2 protein HC660_27360 ENOG4105DCG PHP domain protein HC660_27390 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HC660_27400 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HC660_27410 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HC660_27420 ENOG4108RWN rrna methyltransferase HC660_27430 ENOG41067MF small acid-soluble spore protein HC660_27450 ENOG4105CQB FAD linked oxidase domain protein HC660_27460 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HC660_27490 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HC660_27500 ENOG4105DRS transport system, permease HC660_27530 ENOG4108MDK Dehydrogenase HC660_27550 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HC660_27560 ENOG4105EF1 ribulokinase HC660_27580 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HC660_27600 ENOG4105CN9 Peptidase m42 family protein HC660_27620 ENOG410696E Membrane HC660_27630 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HC660_27640 ENOG4105VJV 50s ribosomal protein L35 HC660_27650 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HC660_27680 ENOG41067MG lrgb family HC660_27700 ENOG4105DY9 regulatoR HC660_27710 ENOG4108HRK Histidine kinase HC660_27730 ENOG4105C22 threonyL-tRNA synthetase HC660_27740 ENOG4108TDW sporulation protein YtxC HC660_27780 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HC660_27790 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HC660_27800 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HC660_27810 ENOG4105KVH Transcriptional regulator HC660_27820 ENOG4105F27 Major Facilitator HC660_27830 ENOG4105CV8 reductase HC660_27840 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HC660_27860 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HC660_27870 ENOG4105C2M dna polymerase I HC660_27880 ENOG4105BZU Histidine kinase HC660_27890 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HC660_27900 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HC660_27910 ENOG4108HMX isocitrate dehydrogenase (NADP) HC660_27920 ENOG4105BZN citrate synthase HC660_27940 ENOG4108REF Sporulation integral membrane protein ytvi HC660_27950 ENOG4105FS0 cytoplasmic membrane protein HC660_27960 ENOG4105CA9 Pyruvate kinase HC660_27970 ENOG4105CTQ phosphohexokinase HC660_27990 ENOG4108IEY Carboxyl transferase domain HC660_28000 ENOG4105C6K Malic enzyme HC660_28010 ENOG4105C0B DNA polymerase III (alpha subunit) HC660_28020 ENOG4105VV2 HC660_28040 ENOG4106EVM HC660_28050 ENOG4105SFS phosphoesterase RecJ domain protein HC660_28080 ENOG4105E8R UPF0173 metal-dependent hydrolase HC660_28100 ENOG4105CH7 arginosuccinase HC660_28110 ENOG4105CDH Citrulline--aspartate ligase HC660_28120 ENOG4105EPU Molybdenum cofactor synthesis domain protein HC660_28130 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HC660_28150 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HC660_28160 ENOG4105KBJ sporulation protein ytfj HC660_28180 ENOG4105VK3 rdd domain containing protein HC660_28190 ENOG4105D07 Signal peptide peptidase, SppA HC660_28200 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HC660_28210 ENOG4105EFZ amidohydrolase HC660_28220 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HC660_28290 ENOG4105U5Y Transcriptional regulator HC660_28310 ENOG4105BZU Histidine kinase HC660_28330 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HC660_28340 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HC660_28360 ENOG4105F1V Acetoin utilization protein HC660_28370 ENOG4105W87 Cbs domain HC660_28380 ENOG4105DGU Histone deacetylase HC660_28390 ENOG4105ER2 Ompa motb domain protein HC660_28400 ENOG4107R0U MotA TolQ exbB proton channel HC660_28410 ENOG4105ETE Transcriptional regulator (LacI family HC660_28420 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HC660_28460 ENOG4105DFU Cell wall formation (By similarity) HC660_28480 ENOG4108VDD TRNA binding domain protein HC660_28510 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ HC660_28540 ENOG4105C6K Malic enzyme HC660_28550 ENOG4105C8F Beta-lactamase domain protein HC660_28560 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HC660_28580 ENOG4108V15 phosphotransferase enzyme family HC660_28590 ENOG4108IUM Glycogen debranching enzyme HC660_28620 ENOG4107F58 2'-5' rna ligase HC660_28630 ENOG4105C6T cysteine synthase HC660_28640 ENOG4107QSE Dipeptidase HC660_28650 ENOG4105C7N Xanthine uracil vitamin C permease HC660_28680 ENOG4105YW5 deoR family transcriptional regulator HC660_28710 ENOG4105CBX hi0933 family HC660_28720 ENOG4105C94 Transporter HC660_28740 ENOG4105MU9 integral membrane protein HC660_28750 ENOG4105DDC Oxidoreductase domain protein HC660_28770 ENOG4105F5H Glycosyl Hydrolase Family 88 HC660_28790 ENOG41075H3 AraC family transcriptional regulator HC660_28810 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HC660_28830 ENOG4106A3M Cytochrome p-450 HC660_28860 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HC660_28870 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HC660_28890 ENOG4105NTD Inherit from COG: Hydrolase HC660_28950 ENOG41085GJ domain protein HC660_28960 ENOG4105C8T Leucyl-tRNA synthetase HC660_28980 ENOG4105BZU Histidine kinase HC660_28990 ENOG410605W Major Facilitator HC660_29000 ENOG4106UBQ HC660_29020 ENOG4105C19 ABC transporter HC660_29030 ENOG4105EWM Histidine kinase HC660_29050 ENOG4107R34 abc transporter permease protein HC660_29060 ENOG4105C19 ABC transporter HC660_29090 ENOG4105DVE abc transporter atp-binding protein HC660_29100 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HC660_29120 ENOG4105N5T Radical SAM Protein HC660_29150 ENOG4105E8V Alpha Beta Hydrolase Fold protein HC660_29160 ENOG4108Z0R Transferase HC660_29170 ENOG4105C85 amino acid HC660_29180 ENOG4105CAQ asparagine synthetase HC660_29190 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HC660_29200 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HC660_29230 ENOG4105D2X ABC transporter substrate-binding protein HC660_29250 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HC660_29280 ENOG4108RMU ferritin dps family protein HC660_29310 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HC660_29320 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HC660_29330 ENOG4108V2W Carbonate dehydratase HC660_29380 ENOG4105CC5 ABC transporter HC660_29390 ENOG4105CC5 ABC transporter HC660_29400 ENOG4105DIK (ABC) transporter HC660_29410 ENOG4105DSE periplasmic solute binding protein HC660_29420 ENOG4105DTQ mandelate racemase muconate lactonizing HC660_29430 ENOG4105CEY Amp-dependent synthetase and ligase HC660_29440 ENOG4108IPT Naphthoate synthase HC660_29450 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HC660_29460 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HC660_29470 ENOG4105E4F Isochorismate synthase HC660_29510 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HC660_29530 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HC660_29790 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HC660_29800 ENOG4105VRR gCN5-related N-acetyltransferase HC660_29810 ENOG4105DZ6 Band 7 protein HC660_29830 ENOG4106DF1 HC660_29840 ENOG4108VNY MOSC domain protein HC660_29850 ENOG4108JB8 alcohol dehydrogenase HC660_29870 ENOG4105TRT Transcriptional regulator HC660_29900 ENOG4105CZN Potassium uptake protein HC660_29910 ENOG4107I77 yiaA/B two helix domain HC660_29920 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HC660_29960 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HC660_29980 ENOG4105EE0 oxidoreductase HC660_29990 ENOG4105DKG l-rhamnose isomerase HC660_30000 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HC660_30010 ENOG4105DET Rhamnulokinase HC660_30020 ENOG4105E98 transcriptional regulator DeoR family HC660_30040 ENOG4105C8Q Methyl-accepting chemotaxis HC660_30050 ENOG4105C8Q Methyl-accepting chemotaxis HC660_30060 ENOG4105C8Q Methyl-accepting chemotaxis HC660_30070 ENOG4105C8Q Methyl-accepting chemotaxis HC660_30100 ENOG4105EA8 2-Nitropropane dioxygenase HC660_30110 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HC660_30130 ENOG4105C37 (CBS) domain HC660_30160 ENOG4107PBV potassium channel HC660_30170 ENOG4107PBV potassium channel HC660_30200 ENOG4107QYV phosphohexose isomerase HC660_30220 ENOG4107QW4 alcohol dehydrogenase HC660_30240 ENOG4105WG9 Conserved Protein HC660_30260 ENOG4105CHM Aminotransferase HC660_30270 ENOG4108ZB6 transcriptional regulator AsnC family HC660_30280 ENOG4108MUZ hydrolase HC660_30300 ENOG4105C87 Aminotransferase class I and II HC660_30310 ENOG4108HGU Histidine kinase HC660_30320 ENOG4105Y38 Kinase-associated protein B HC660_30360 ENOG4105BZ4 penicillin-binding protein HC660_30370 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HC660_30400 ENOG4108MRH transcriptional regulatory protein HC660_30410 ENOG4105DIH basic membrane HC660_30420 ENOG4108JQ9 ABC transporter HC660_30430 ENOG4105UIB (ABC) transporter HC660_30470 ENOG4105D65 subunit l HC660_30480 ENOG4105HC0 Na H antiporter HC660_30490 ENOG4108ZE9 Monovalent cation H antiporter subunit C HC660_30500 ENOG4108JPZ Monovalent cation H antiporter subunit D HC660_30510 ENOG4105SC1 monovalent cation H antiporter subunit E HC660_30530 ENOG4105KJM monovalent cation h antiporter subunit g HC660_30540 ENOG4105KA0 thioesterase Superfamily protein HC660_30560 ENOG4105BZU Histidine kinase HC660_30600 ENOG4105D58 Diguanylate phosphodiesterase HC660_30610 ENOG4105DAP Nicotinate phosphoribosyltransferase HC660_30660 ENOG4105C02 permease HC660_30690 ENOG410904N short-chain dehydrogenase reductase HC660_30770 ENOG4108K8K Transcriptional regulator HC660_30780 ENOG4105DCF alanine dehydrogenase HC660_30800 ENOG4105WQT MbtH domain protein HC660_30810 ENOG4105CEY Amp-dependent synthetase and ligase HC660_30820 ENOG4105WQI isochorismatase HC660_30830 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HC660_30840 ENOG4105E4F Isochorismate synthase HC660_30850 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HC660_30860 ENOG4105NIV Esterase HC660_30900 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HC660_30920 ENOG41069ER domain protein HC660_30940 ENOG4105CEP NADH dehydrogenase HC660_30950 ENOG4105CAY ferredoxin--nadp reductase HC660_30980 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HC660_31010 ENOG4105ZKE UPF0349 protein HC660_31040 ENOG41083MR nifu domain-containing protein HC660_31050 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HC660_31060 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HC660_31070 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HC660_31080 ENOG4105D6E homoserine dehydrogenase HC660_31100 ENOG4108W5N phosphatidylglycerophosphatase a HC660_31110 ENOG4105D4U had-superfamily hydrolase, subfamily iia HC660_31130 ENOG4105MMD transcriptional regulator HC660_31140 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HC660_31150 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HC660_31160 ENOG4105FAA peptidase M23 HC660_31170 ENOG4108YTE sporulation protein YunB HC660_31180 ENOG4105KZD Domain of unknown function (DUF1805) HC660_31190 ENOG4107R8B 5'-nucleotidase HC660_31210 ENOG4105I3N Conserved Protein HC660_31230 ENOG4105CD3 dihydroorotase HC660_31240 ENOG4105G9B Transcriptional regulator HC660_31270 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HC660_31280 ENOG4105VT2 5-hydroxyisourate hydrolase HC660_31290 ENOG4107YV9 domain protein HC660_31300 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HC660_31330 ENOG4105XRQ Xanthine dehydrogenase accessory factor HC660_31340 ENOG4105C5R Aminotransferase HC660_31360 ENOG4108K8S endonuclease I HC660_31370 ENOG4108IJ9 (ABC) transporter HC660_31380 ENOG4105FDP GntR family transcriptional regulator HC660_31390 ENOG4108KPW sugar kinase HC660_31400 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HC660_31410 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HC660_31420 ENOG4105XN3 extracellular solute-binding protein family 1 HC660_31430 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HC660_31440 ENOG4105PKS Excinuclease abc c subunit domain protein HC660_31450 ENOG4107VFR oxidoreductase HC660_31480 ENOG4105DIW FeS assembly protein SUFB HC660_31490 ENOG4108UNV SUF system FeS assembly protein, NifU family HC660_31500 ENOG4105C9B Cysteine desulfurase HC660_31510 ENOG4105JRK feS assembly protein SufD HC660_31520 ENOG4105C3K feS assembly ATPase SufC HC660_31550 ENOG4105D01 (LipO)protein HC660_31560 ENOG4108UMI ABC transporter, permease HC660_31570 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HC660_31620 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HC660_31630 ENOG41080E8 Transcriptional regulator, Spx MgsR family HC660_31640 ENOG4105C1G acyl-Coa dehydrogenase HC660_31650 ENOG4105CHU acetyl-coa acetyltransferase HC660_31700 ENOG41067TZ transcriptional regulator, MarR family HC660_31710 ENOG4105C0R drug resistance transporter emrb qaca subfamily HC660_31720 ENOG4105MDS 4-oxalocrotonate tautomerase HC660_31740 ENOG4105EGI Transcriptional regulator HC660_31760 ENOG4105E0A ABC, transporter HC660_31790 ENOG4105E1F short-chain dehydrogenase reductase HC660_31800 ENOG4105HUF DNA protection during starvation protein HC660_31810 ENOG4105C0H protease HC660_31830 ENOG4105F3H Histidine kinase HC660_31850 ENOG41067SE Tetr family transcriptional regulator HC660_31860 ENOG4105C9Q fumarate hydratase class II HC660_31910 ENOG4105WH1 Two component transcriptional regulator luxr family HC660_31920 ENOG4105ENE Histidine kinase HC660_31950 ENOG41087YS Phage shock protein A HC660_31980 ENOG4108WBT adenosyltransferase HC660_31990 ENOG4105E0A ABC, transporter HC660_32000 ENOG4105EHG Permease protein HC660_32010 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HC660_32020 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HC660_32030 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HC660_32050 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HC660_32070 ENOG4106DF4 Sigma-70, region 4 HC660_32090 ENOG4105F0F Oxalate decarboxylase HC660_32110 ENOG4107RBB ABC transporter, permease HC660_32120 ENOG4105C19 ABC transporter HC660_32130 ENOG4108WMK Efflux transporter RND family MFP subunit HC660_32140 ENOG4105E0A ABC, transporter HC660_32150 ENOG4105EHG Permease protein HC660_32160 ENOG4105DQ5 transport system permease protein HC660_32180 ENOG4105D5Q Arginine ornithine antiporter HC660_32200 ENOG4107K5X Membrane-bound metal-dependent hydrolase HC660_32210 ENOG4107QZ2 Sulfatase HC660_32220 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HC660_32230 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HC660_32240 ENOG4105E0C molybdate abc transporter HC660_32270 ENOG4105EEQ Na H antiporter HC660_32280 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HC660_32290 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HC660_32300 ENOG4105EEM helicase HC660_32310 ENOG4105EN6 Membrane HC660_32330 ENOG4107ZQN disulfide bond HC660_32340 ENOG4105C59 p-type ATPase HC660_32350 ENOG4105C59 p-type ATPase HC660_32360 ENOG410681U heavy metal transport detoxification protein HC660_32370 ENOG4105VPX protein, conserved in bacteria HC660_32380 ENOG4105D9R oxidoreductase HC660_32390 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HC660_32400 ENOG4105ME7 Membrane HC660_32410 ENOG4105DRR Transcriptional regulator, GntR family HC660_32420 ENOG4108UZ3 Transporter HC660_32430 ENOG4105RXJ HC660_32440 ENOG4105KPY Small multidrug resistance protein HC660_32450 ENOG4105KBX Transcriptional regulator, TetR family HC660_32460 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HC660_32470 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HC660_32480 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HC660_32500 ENOG4105XZU Preprotein translocase, subunit SecG HC660_32550 ENOG4105KVH Transcriptional regulator HC660_32600 ENOG4105DA5 (ABC) transporter HC660_32650 ENOG4105R40 Glycine betaine carnitine choline HC660_32660 ENOG4108HQR Glycine betaine HC660_32670 ENOG4105E90 ABC transporter HC660_32680 ENOG4108IJ8 ABC transporter HC660_32690 ENOG4107HG4 Transcriptional regulator HC660_32700 ENOG4105R40 Glycine betaine carnitine choline HC660_32710 ENOG4108HQR Glycine betaine HC660_32720 ENOG4105E90 ABC transporter HC660_32730 ENOG4108IJ8 ABC transporter HC660_32740 ENOG4107HG4 Transcriptional regulator HC660_32750 ENOG4108QCI YvbH-like oligomerisation region HC660_32770 ENOG4105T65 Membrane-associated protein HC660_32780 ENOG4108W0I acetyltransferase HC660_32790 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HC660_32800 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HC660_32810 ENOG4105CP7 Triose-phosphate isomerase HC660_32820 ENOG4105BZA Phosphoglycerate kinase HC660_32830 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HC660_32860 ENOG4105CMD Transcriptional regulator, GntR family HC660_32870 ENOG4105DEN Luciferase family HC660_32880 ENOG4105GZI Transcriptional regulator HC660_32890 ENOG4107RT3 EamA-like transporter family HC660_32910 ENOG4105VRS hydrolase family 18 HC660_32920 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HC660_32930 ENOG4107QR9 Iron-sulfur cluster binding protein HC660_32940 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HC660_32960 ENOG4105BZU Histidine kinase HC660_32970 ENOG4105KCT ABC transporter HC660_32980 ENOG4108M15 ABC transporter HC660_32990 ENOG4107R6F Alpha Beta Hydrolase Fold protein HC660_33000 ENOG4108MJI response regulator HC660_33030 ENOG4105EG2 ABC transporter, permease HC660_33050 ENOG4107FKK extracellular solute-binding protein family 1 HC660_33070 ENOG4105JXH GntR family transcriptional regulator HC660_33080 ENOG4105DAA L-lactate HC660_33090 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HC660_33110 ENOG4108ZPC Polysaccharide pyruvyl transferase HC660_33120 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HC660_33130 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HC660_33140 ENOG4105D3Q Sugar transferase HC660_33160 ENOG4105K64 Glycosyl transferase, family 2 HC660_33180 ENOG4107QRS glycosyltransferase group 2 family protein HC660_33190 ENOG41068W6 Capsular polysaccharide biosynthesis protein HC660_33200 ENOG4108KMV Glycosyl transferase (Group 1 HC660_33210 ENOG4105K64 Glycosyl transferase, family 2 HC660_33220 ENOG4108PQP glycosyl transferase group 1 HC660_33240 ENOG4108QV3 biosynthesis protein HC660_33250 ENOG4105HTX biosynthesis protein HC660_33270 ENOG4105EBR Carboxylesterase HC660_33280 ENOG4105PY6 Phenolic acid decarboxylase HC660_33290 ENOG4105NI3 Protein of unknown function (DUF3237) HC660_33310 ENOG4105FQP Beta-lactamase HC660_33340 ENOG4108UXE Protein tyrosine phosphatase HC660_33350 ENOG4107R5R arsenical pump membrane protein HC660_33360 ENOG41082YX Transcriptional regulator, arsr family HC660_33370 ENOG4105EDQ levansucrase EC 2.4.1.10 HC660_33380 ENOG4108HKT sucrose-6-phosphate hydrolase HC660_33390 ENOG4107QTZ amino acid HC660_33450 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HC660_33460 ENOG4107URF beta-phospho-glucomutase HC660_33470 ENOG4105FKQ transcriptional regulator HC660_33480 ENOG4108URH decarboxylase HC660_33490 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain HC660_33500 ENOG4105CHH sulfate transporter HC660_33510 ENOG4108V2W Carbonate dehydratase HC660_33520 ENOG4105C5I Dehydrogenase HC660_33540 ENOG4105C19 ABC transporter HC660_33550 ENOG4105EWM Histidine kinase HC660_33570 ENOG4107A6P HC660_33580 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HC660_33590 ENOG4105KRI phosphocarrier protein (HPr HC660_33600 ENOG4105CIE May be required for sporulation (By similarity) HC660_33610 ENOG4105CHW UPF0052 protein HC660_33620 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HC660_33630 ENOG4108Z4K mutator MutT protein HC660_33640 ENOG4105C3M thioredoxin reductase HC660_33670 ENOG4105BZ1 (ABC) transporter HC660_33690 ENOG4106FGC HC660_33710 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HC660_33720 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HC660_33730 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HC660_33740 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HC660_33750 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HC660_33760 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HC660_33770 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HC660_33780 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HC660_33800 ENOG4108E16 pectate lyase HC660_33810 ENOG4108S4C acetyltransferase HC660_33820 ENOG4107XGZ Hydrolase HC660_33830 ENOG4105HKU nucleoside recognition domain-containing protein HC660_33840 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HC660_33850 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HC660_33860 ENOG4105CE4 GlcNAc 6-P deacetylase HC660_33870 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HC660_33890 ENOG41088CQ domain protein HC660_33910 ENOG4106A3M Cytochrome p-450 HC660_33920 ENOG410625E HC660_33950 ENOG41086DT Membrane protein of unknown function HC660_33960 ENOG41067S9 phage shock protein C, PspC HC660_33970 ENOG4108PY7 HC660_34000 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HC660_34010 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HC660_34040 ENOG4105MKU Transcriptional regulator HC660_34080 ENOG4105CN1 protease HC660_34090 ENOG4105CRP Part of the ABC transporter FtsEX involved in HC660_34100 ENOG4105CAK Cell division ATP-binding protein ftsE HC660_34130 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HC660_34150 ENOG4105MS2 ribosomal subunit Interface protein HC660_34180 ENOG4105MQ3 flagellar protein FliS HC660_34190 ENOG4107RT6 flagellar hook-associated HC660_34200 ENOG41083S7 flagellar protein FlaG HC660_34210 ENOG4105I03 Flagellin HC660_34220 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HC660_34230 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HC660_34240 ENOG4105MKD HC660_34250 ENOG4105DTJ flagellar hook-associated protein HC660_34260 ENOG4105E1Q flagellar hook-associated protein HC660_34290 ENOG4105RU3 HC660_34300 ENOG41081UC Inherit from COG: Competence protein HC660_34340 ENOG4105WH1 Two component transcriptional regulator luxr family HC660_34350 ENOG4105BZU Histidine kinase HC660_34360 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HC660_34370 ENOG4108KGH TRANSCRIPTIONal HC660_34380 ENOG4105ESV Glycosyl transferase, family 4 HC660_34390 ENOG4107EF8 Glycosyl transferase (Group 1 HC660_34420 ENOG4105QZI O-Antigen Polymerase HC660_34430 ENOG4105C6Y Udp-glucose 6-dehydrogenase HC660_34440 ENOG4107RA4 Glycosyl transferase (Group 1 HC660_34450 ENOG4105PSV Polysaccharide Biosynthesis Protein HC660_34460 ENOG4105D3Q Sugar transferase HC660_34480 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HC660_34490 ENOG4105JFG SpoIID LytB domain protein HC660_34520 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HC660_34560 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HC660_34570 ENOG4105EY8 ABC transporter HC660_34620 ENOG41088M2 Glycosyl transferase family 2 HC660_34720 ENOG4105DG6 mannose-6-phosphate isomerase HC660_34750 ENOG4108NHD germination protein HC660_34760 ENOG4105C54 Major Facilitator superfamily HC660_34770 ENOG4108KGH TRANSCRIPTIONal HC660_34780 ENOG4105J7I hydrolase HC660_34790 ENOG4105K4H Nlp p60 protein HC660_34810 ENOG4105PNM synthesis protein HC660_34830 ENOG4105N98 Capsule biosynthesis protein capB HC660_34840 ENOG4105ETE Transcriptional regulator (LacI family HC660_34850 ENOG4108RVA ribokinase HC660_34860 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HC660_34870 ENOG4105C2J ABC transporter HC660_34880 ENOG4105CNN ABC, transporter HC660_34890 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HC660_34920 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HC660_34930 ENOG4107FQX Alpha-acetolactate decarboxylase HC660_34950 ENOG4107RSM transcriptional regulator HC660_34980 ENOG4106UIA HC660_35010 ENOG4107XC4 flavin reductase domain protein, FMN-binding HC660_35020 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HC660_35050 ENOG4105UP7 3-epimerase HC660_35070 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HC660_35090 ENOG4105CAH Chromate HC660_35100 ENOG4105FGV Chromate HC660_35170 ENOG4105C6Y Udp-glucose 6-dehydrogenase HC660_35180 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HC660_35190 ENOG4107YJ4 chain length determinant protein HC660_35200 ENOG4105HTX biosynthesis protein HC660_35210 ENOG4105KBK Zinc finger, swim domain protein HC660_35220 ENOG4105C0D helicase HC660_35230 ENOG410667J hydrolase HC660_35240 ENOG4105E98 transcriptional regulator DeoR family HC660_35250 ENOG4105Z8H single-stranded DNA-binding protein HC660_35280 ENOG4108HWY Beta-lactamase HC660_35290 ENOG4108Z6X (sortase) family HC660_35310 ENOG4108VAC response regulator HC660_35330 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HC660_35340 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HC660_35360 ENOG4105CGA flagellar basal-body rod protein FlgG HC660_35380 ENOG4105DFF Rod shape-determining protein mreb HC660_35390 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HC660_35400 ENOG4107MII Sugar-specific transcriptional regulator TrmB HC660_35410 ENOG4105CZM Major Facilitator HC660_35420 ENOG4108M26 parallel beta-helix repeat protein HC660_35430 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HC660_35440 ENOG41080V3 Major Facilitator superfamily HC660_35450 ENOG4105D3W isochorismatase HC660_35460 ENOG4107P26 HC660_35470 ENOG4105BZU Histidine kinase HC660_35490 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HC660_35510 ENOG4105FRN stage II sporulation protein HC660_35520 ENOG4107TCE N-acetyltransferase HC660_35540 ENOG4105C5E polysaccharide biosynthesis protein HC660_35550 ENOG4105C1B dTDP-glucose 4-6-dehydratase HC660_35570 ENOG4107TY6 Acylneuraminate cytidylyltransferase HC660_35620 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HC660_35630 ENOG4106BRK HC660_35640 ENOG4108RYK Nad-dependent epimerase dehydratase HC660_35650 ENOG4108Z40 Transcriptional regulator HC660_35660 ENOG4105CQM Urea amidohydrolase subunit alpha HC660_35670 ENOG4105KI2 Urea amidohydrolase subunit beta HC660_35680 ENOG4108YZ9 Urea amidohydrolase subunit gamma HC660_35690 ENOG4108IV0 ABC, transporter HC660_35700 ENOG4105C0Z ABC transporter HC660_35720 ENOG4105C32 Amino acid ABC transporter (Permease) HC660_35730 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HC660_35780 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HC660_35800 ENOG4108TF4 von Willebrand factor, type A HC660_35820 ENOG4105JFG SpoIID LytB domain protein HC660_35830 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HC660_35850 ENOG4106778 Protein of unknown function (DUF1146) HC660_35870 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HC660_35880 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HC660_35890 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HC660_35900 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HC660_35940 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) HC660_35960 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HC660_35970 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HC660_35980 ENOG4108UIC UPF0340 protein HC660_35990 ENOG4108YZG isomerase HC660_36000 ENOG4107WAU Protein tyrosine phosphatase HC660_36010 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HC660_36020 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HC660_36040 ENOG4108ZXQ stage ii sporulation protein r HC660_36070 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HC660_36080 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HC660_36090 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HC660_36110 ENOG4107TT2 Auxin Efflux Carrier HC660_36120 ENOG4105C6K Malic enzyme HC660_36130 ENOG4107104 thymidine kinase HC660_36150 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HC660_36170 ENOG4105CBT Fructose-1,6-bisphosphatase HC660_36180 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HC660_36190 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway HC660_36200 ENOG4105D2N Aldolase HC660_36210 ENOG410812K response regulator receiver protein HC660_36230 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HC660_36250 ENOG4105C1G acyl-Coa dehydrogenase HC660_36260 ENOG4105DF6 Fe-S oxidoreductase HC660_36280 ENOG4105E5J UV damage endonuclease HC660_36300 ENOG4105NAE bifunctional deaminase-reductase domain protein HC660_36310 ENOG4105BZ1 (ABC) transporter HC660_36320 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HC660_36350 ENOG4105R3A Nitrate reductase HC660_36360 ENOG4108IUE nitrate reductase beta subunit HC660_36400 ENOG4107V6Q Cyclic nucleotide-binding domain HC660_36420 ENOG4105C75 arginyL-tRNA synthetase HC660_36430 ENOG410684U Domain of unknown function (DUF1934) HC660_36450 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HC660_36540 ENOG4107JM4 Tetratricopeptide repeat HC660_36550 ENOG4105CYW agmatinase HC660_36560 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HC660_36570 ENOG4105BZ4 penicillin-binding protein HC660_36590 ENOG4108XFG YwhD family HC660_36600 ENOG4108Z4T Peptidase M50 HC660_36610 ENOG41069HH 4-oxalocrotonate tautomerase HC660_36620 ENOG41067TZ transcriptional regulator, MarR family HC660_36630 ENOG4105C22 threonyL-tRNA synthetase HC660_36650 ENOG4105C57 major facilitator superfamily HC660_36660 ENOG41062ES Transcriptional regulator HC660_36680 ENOG4105DCI Phosphohydrolase HC660_36700 ENOG4108VCI transcription factor, rsfa family HC660_36710 ENOG4108RNG Permease of the drug metabolite transporter HC660_36720 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HC660_36730 ENOG4105DUM transcriptional regulator, lysR family HC660_36740 ENOG4108IJ2 phosphate acetyltransferase HC660_36770 ENOG4105CHM Aminotransferase HC660_36790 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase HC660_36800 ENOG4105CHR reductase HC660_36810 ENOG4106CHD Bacilysin biosynthesis protein bacB HC660_36820 ENOG41061WN bacilysin biosynthesis protein HC660_36830 ENOG4105FCW Major Facilitator superfamily HC660_36840 ENOG4105C2C drug resistance transporter, Bcr CflA HC660_36870 ENOG4105C26 Dehydrogenase HC660_36880 ENOG4105D82 Glutamate dehydrogenase HC660_36900 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase HC660_36910 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HC660_36920 ENOG4105C1B dTDP-glucose 4-6-dehydratase HC660_36930 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HC660_36940 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD HC660_37010 ENOG4105C26 Dehydrogenase HC660_37020 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HC660_37030 ENOG4108RJ9 Glycosyl transferase, family 2 HC660_37070 ENOG4105DWF phosphomethylpyrimidine kinase HC660_37100 ENOG4105C5Y PTS System HC660_37110 ENOG4108QTI )-transporter HC660_37140 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HC660_37150 ENOG4105DEN Luciferase family HC660_37160 ENOG4108DBC nitroreductase HC660_37210 ENOG4105BZ9 Cytochrome C oxidase, subunit I HC660_37220 ENOG4105E2S oxidase) subunit II HC660_37230 ENOG4107BMA Transglycosylase associated protein HC660_37250 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HC660_37260 ENOG4105WH5 Teichoic acid glycosylation protein HC660_37320 ENOG4107ZXU DSBA oxidoreductase HC660_37330 ENOG4105DBE peroxidase HC660_37340 ENOG410650H (LipO)protein HC660_37350 ENOG4107SJW iron permease, FTR1 HC660_37360 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HC660_37380 ENOG4105CMU LysR family (Transcriptional regulator HC660_37390 ENOG4105VAW lrga family HC660_37400 ENOG41067MG lrgb family HC660_37410 ENOG4108RDQ ABC transporter HC660_37460 ENOG41067MG lrgb family HC660_37480 ENOG4105DR4 Methyltransferase HC660_37500 ENOG4108YV3 Protein of unknown function (DUF2711) HC660_37510 ENOG4105CK1 PTS System HC660_37520 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HC660_37550 ENOG4105X1N Glycosyl transferase family 8 HC660_37570 ENOG4105GVJ transcriptional regulator HC660_37580 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HC660_37590 ENOG4105IIU Aminopeptidase HC660_37610 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HC660_37620 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HC660_37630 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HC660_37650 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HC660_37660 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HC660_37670 ENOG4105CM2 brancheD-chain amino acid aminotransferase HC660_37680 ENOG4105F8D glycoside hydrolase family 4 HC660_37690 ENOG4105VCP PTS System HC660_37700 ENOG4105CK1 PTS System HC660_37710 ENOG4105VZJ PTS System HC660_37720 ENOG4105EMD TRANSCRIPTIONal HC660_37740 ENOG4108VX5 3-methyladenine DNA glycosylase HC660_37750 ENOG4105CH6 catalase HC660_37790 ENOG4105DA5 (ABC) transporter HC660_37800 ENOG41069JR HC660_37840 ENOG4105ETS cytosine purines uracil thiamine allantoin HC660_37850 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HC660_37860 ENOG4108JJ8 (ABC) transporter HC660_37870 ENOG4108JJ9 ABC, transporter HC660_37880 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HC660_37890 ENOG4105C4M (Ubiquinol oxidase) subunit I HC660_37900 ENOG4105D2K citrate carrier protein HC660_37920 ENOG4107BJW polysaccharide deacetylase HC660_37960 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HC660_37980 ENOG4105CMR udp-glucose 4-epimerase HC660_37990 ENOG4105KIS phospholipid-binding protein HC660_38000 ENOG4108WAV Transcriptional regulator HC660_38020 ENOG4105BZU Histidine kinase HC660_38030 ENOG4105WH1 Two component transcriptional regulator luxr family HC660_38040 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HC660_38090 ENOG4108JUB Transcriptional regulator HC660_38100 ENOG4105DTD Dehydrogenase HC660_38110 ENOG4108IIH CoA-transferase subunit B HC660_38120 ENOG4105D6N CoA-transferase, subunit a HC660_38130 ENOG4105CY2 Citrate transporter HC660_38140 ENOG4105DHI Methyltransferase HC660_38180 ENOG4105CH6 catalase HC660_38190 ENOG4105D4T Citrate transporter HC660_38210 ENOG4105DEU major facilitator superfamily HC660_38220 ENOG4105C1J atp-dependent rna helicase HC660_38230 ENOG4107TDE lipolytic protein G-D-S-L family HC660_38400 ENOG4107TS3 membrane protein, TerC HC660_38410 ENOG4107YZX Universal stress protein HC660_38420 ENOG4107YZX Universal stress protein HC660_38460 ENOG4107EV6 Inherit from COG: YD repeat protein HC660_38490 ENOG4107EV6 Inherit from COG: YD repeat protein HC660_38520 ENOG4106Z5D Glycoside Hydrolase Family 43 HC660_38550 ENOG4105C84 Histidine ammonia-lyase HC660_38560 ENOG4105CGP Urocanate hydratase HC660_38570 ENOG4105CI2 imidazolone-5-propionate hydrolase HC660_38580 ENOG4107W25 arginase agmatinase formiminoglutamase HC660_38600 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HC660_38610 ENOG4105D9N nucleoside HC660_38630 ENOG4107RHR regulatoR HC660_38640 ENOG4108TM9 integral membrane protein HC660_38650 ENOG4105ENY Ethanolamine utilization protein eutH HC660_38660 ENOG4108PGP mmge prpd family protein HC660_38690 ENOG4108HW4 amino acid AbC transporter HC660_38700 ENOG4105EAB amino acid AbC transporter HC660_38730 ENOG4107QHE Choloylglycine hydrolase HC660_38740 ENOG410667J hydrolase HC660_38800 ENOG4108V5C ABC transporter HC660_38860 ENOG4105D2N Aldolase HC660_38870 ENOG4105WZ4 isomerase HC660_38880 ENOG4105F0H myo-inositol catabolism protein HC660_38890 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HC660_38910 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HC660_38920 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HC660_38930 ENOG4105D7K pfkb domain protein HC660_38950 ENOG4105C26 Dehydrogenase HC660_38970 ENOG4105CPC Aldo Keto reductase HC660_39000 ENOG4107QNK )-transporter HC660_39010 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HC660_39030 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HC660_39040 ENOG4105ST3 Transcriptional regulator HC660_39050 ENOG4105C26 Dehydrogenase HC660_39080 ENOG41085PJ rdd domain containing protein HC660_39110 ENOG4105J7D transcriptional regulator HC660_39120 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HC660_39130 ENOG41061AU MarR family Transcriptional regulator HC660_39180 ENOG4105BZW Glycerate kinase HC660_39190 ENOG4105G3Z GntR family transcriptional regulator HC660_39200 ENOG4105CMG Carbohydrate kinase HC660_39210 ENOG4105C6Z Gluconate HC660_39220 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HC660_39230 ENOG4105D3R alkyl hydroperoxide reductase HC660_39240 ENOG4108JU3 Alkyl hydroperoxide reductase HC660_39250 ENOG4105CS2 ec 3.2.1.21 HC660_39270 ENOG4108S3Y transcriptional regulator HC660_39280 ENOG4106KKU HC660_39290 ENOG4108Z15 abc transporter atp-binding protein HC660_39300 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 HC660_39340 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HC660_39370 ENOG4105E2A Dehydrogenase HC660_39410 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HC660_39420 ENOG4105WQG acetyltransferase HC660_39430 ENOG410780I phosphoprotein phosphatase activity HC660_39450 ENOG41066UZ arginase EC 3.5.3.1 HC660_39460 ENOG4108IQI permease HC660_39470 ENOG4105C8Y Acetylornithine aminotransferase HC660_39480 ENOG4108JUB Transcriptional regulator HC660_39490 ENOG4105C0H protease HC660_39500 ENOG4105Q2H domain protein HC660_39530 ENOG4105BZU Histidine kinase HC660_39540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HC660_39590 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HC660_39600 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HC660_39610 ENOG4105CDU Replicative dna helicase HC660_39650 ENOG4105DJ2 Major Facilitator Superfamily HC660_39660 ENOG4105EDW glycosyl transferase, family 39 HC660_39670 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HC660_39680 ENOG4105BZR domain protein HC660_39690 ENOG4108XMW Membrane HC660_39720 ENOG4105KVH Transcriptional regulator HC660_39730 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HC660_39770 ENOG4105D94 Major Facilitator Superfamily HC660_39780 ENOG4107RSM transcriptional regulator HC660_39790 ENOG41082BV acetyltransferase HC660_39800 ENOG41081I9 integral membrane protein HC660_39810 ENOG4107V2S Transcriptional regulator HC660_39820 ENOG4108VP3 Lysine exporter protein (LysE YggA) HC660_39840 ENOG4108ZHR arsR family transcriptional regulator HC660_39850 ENOG4108SQ9 flavin reductase domain protein, FMN-binding HC660_39880 ENOG4105EYF MMPL domain protein HC660_39890 ENOG4108VB1 regulatoR HC660_39900 ENOG4105ENE Histidine kinase HC660_39920 ENOG4105UNS Pfam:DUF419 HC660_39930 ENOG4105NAE bifunctional deaminase-reductase domain protein HC660_39940 ENOG4105C7Z Conserved Protein HC660_40000 ENOG4108IMY Transcriptional regulator HC660_40010 ENOG41068WC Domain of unknown function (DUF955) HC660_40030 ENOG4105C7Z Conserved Protein HC660_40040 ENOG4107FCW Abortive infection protein HC660_40060 ENOG4108UW5 maltose o-acetyltransferase HC660_40070 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HC660_40090 ENOG4105CGK Exodeoxyribonuclease III HC660_40100 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HC660_40110 ENOG4108UUM single-stranded DNA-binding protein HC660_40120 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HC660_40130 ENOG4105C3G gtp-binding protein HC660_40140 ENOG4108J2R molybdopterin oxidoreductase HC660_40150 ENOG4105VDK protein, conserved in bacteria HC660_40180 ENOG4108ZDA Sporulation protein YyaC HC660_40190 ENOG4105FA0 parb-like partition protein HC660_40200 ENOG4107QJE Chromosome Partitioning Protein HC660_40230 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HC660_40240 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HC660_40250 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HC660_40280 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)