locus-tag	class	description
HC660_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HC660_00020	COG0592	DNA-directed DNA polymerase activity
HC660_00030	COG2501	S4 domain
HC660_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC660_00060	COG0187	DNA topoisomerase II activity
HC660_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC660_00140	COG0517	IMP dehydrogenase activity
HC660_00140	COG0516	GMP reductase activity
HC660_00150	COG1686	Belongs to the peptidase S11 family
HC660_00170	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HC660_00180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HC660_00200	COG1428	Deoxynucleoside kinase
HC660_00210	COG1428	Deoxynucleoside kinase
HC660_00220	COG3858	chitin binding
HC660_00220	COG1388	LysM domain
HC660_00230	COG1335	isochorismatase
HC660_00240	COG0590	tRNA wobble adenosine to inosine editing
HC660_00250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HC660_00260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HC660_00270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HC660_00360	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HC660_00370	COG3853	Toxic anion resistance protein (TelA)
HC660_00380	COG1982	Orn Lys Arg decarboxylase major
HC660_00390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HC660_00400	COG3870	Protein conserved in bacteria
HC660_00410	COG1728	Protein conserved in bacteria
HC660_00420	COG0470	DNA polymerase III
HC660_00430	COG1774	PSP1 C-terminal conserved region
HC660_00450	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HC660_00460	COG2827	Endonuclease containing a URI domain
HC660_00470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HC660_00480	COG2002	toxin-antitoxin pair type II binding
HC660_00490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC660_00490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC660_00500	COG0084	hydrolase, TatD family'
HC660_00510	COG3584	3D domain protein
HC660_00510	COG3583	domain protein
HC660_00520	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC660_00530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC660_00550	COG4466	Protein conserved in bacteria
HC660_00570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HC660_00580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC660_00590	COG0251	oxidation-reduction process
HC660_00600	COG2088	sporulation resulting in formation of a cellular spore
HC660_00610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC660_00620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HC660_00630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HC660_00640	COG0193	aminoacyl-tRNA hydrolase activity
HC660_00660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HC660_00670	COG2002	toxin-antitoxin pair type II binding
HC660_00680	COG2244	polysaccharide biosynthetic process
HC660_00690	COG3956	TIGRFAM MazG family protein
HC660_00700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HC660_00730	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HC660_00740	COG1098	S1 RNA binding domain
HC660_00770	COG2208	phosphoserine phosphatase activity
HC660_00780	COG2304	oxidoreductase activity
HC660_00790	COG0515	serine threonine protein kinase
HC660_00800	COG0037	tRNA processing
HC660_00820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC660_00830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HC660_00840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HC660_00850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC660_00860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC660_00870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC660_00880	COG0512	Glutamine amidotransferase of anthranilate synthase
HC660_00890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC660_00900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC660_00910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC660_00920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HC660_00930	COG1396	sequence-specific DNA binding
HC660_00940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC660_00950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HC660_01110	COG4463	regulation of RNA biosynthetic process
HC660_01120	COG3880	PFAM UvrB UvrC protein
HC660_01130	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HC660_01140	COG0542	response to heat
HC660_01150	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HC660_01160	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HC660_01170	COG4956	integral membrane protein (PIN domain superfamily)
HC660_01180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HC660_01190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC660_01200	COG1045	serine acetyltransferase
HC660_01210	COG0215	cysteine-tRNA ligase activity
HC660_01220	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HC660_01230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC660_01240	COG3688	RNA-binding protein containing a PIN domain
HC660_01250	COG1595	DNA-templated transcription, initiation
HC660_01260	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC660_01270	COG0250	Participates in transcription elongation, termination and antitermination
HC660_01290	COG0081	regulation of translation
HC660_01300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HC660_01320	COG2813	Specifically methylates the guanine in position
HC660_01330	COG0085	RNA polymerase activity
HC660_01340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HC660_01350	COG1358	cellular component organization or biogenesis
HC660_01370	COG0049	tRNA binding
HC660_01380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC660_01390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC660_01400	COG0596	Alpha beta hydrolase
HC660_01420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HC660_01450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC660_01490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HC660_01510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HC660_01520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HC660_01540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC660_01560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HC660_01570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HC660_01580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HC660_01610	COG0200	Binds to the 23S rRNA
HC660_01620	COG0201	protein transport
HC660_01630	COG0563	adenylate kinase activity
HC660_01640	COG0024	Methionine aminopeptidase
HC660_01660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HC660_01680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HC660_01690	COG0202	RNA polymerase activity
HC660_01700	COG0203	ribosomal protein L17
HC660_01710	COG1122	ATPase activity
HC660_01720	COG1122	ATPase activity
HC660_01730	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC660_01740	COG0101	tRNA pseudouridine synthase activity
HC660_01750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HC660_01770	COG2226	methyltransferase
HC660_01790	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC660_01800	COG0489	protein tyrosine kinase activity
HC660_01820	COG2194	sulfuric ester hydrolase activity
HC660_01830	COG0726	polysaccharide deacetylase
HC660_01990	COG0659	secondary active sulfate transmembrane transporter activity
HC660_02000	COG0385	Bile acid
HC660_02010	COG2819	hydrolase of the alpha beta superfamily
HC660_02020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC660_02030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC660_02040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC660_02050	COG2207	Transcriptional regulator
HC660_02050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC660_02060	COG3876	Protein conserved in bacteria
HC660_02070	COG1472	Belongs to the glycosyl hydrolase 3 family
HC660_02080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC660_02090	COG1263	PTS System
HC660_02090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC660_02100	COG1737	Transcriptional regulator
HC660_02110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HC660_02120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC660_02130	COG1683	Conserved Protein
HC660_02190	COG1595	DNA-templated transcription, initiation
HC660_02200	COG5662	AntiSigma factor
HC660_02210	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC660_02220	COG4856	YbbR-like protein
HC660_02230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC660_02250	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC660_02260	COG2169	Transcriptional regulator
HC660_02270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC660_02280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC660_02290	COG3002	Belongs to the UPF0753 family
HC660_02300	COG0288	reversible hydration of carbon dioxide
HC660_02320	COG5609	conserved protein (DUF2294)
HC660_02330	COG0640	Transcriptional regulator
HC660_02340	COG2814	Major facilitator Superfamily
HC660_02360	COG0596	Alpha beta hydrolase
HC660_02370	COG0745	RESPONSE REGULATOR receiver
HC660_02380	COG0642	Histidine kinase
HC660_02390	COG0515	serine threonine protein kinase
HC660_02420	COG1113	amino acid transport
HC660_02450	COG2602	Beta-lactamase
HC660_02460	COG2124	cytochrome p450
HC660_02480	COG0531	amino acid
HC660_02490	COG1283	sodium-dependent phosphate transmembrane transporter activity
HC660_02500	COG0584	glycerophosphoryl diester phosphodiesterase
HC660_02510	COG2271	Major facilitator Superfamily
HC660_02530	COG0456	acetyltransferase
HC660_02530	COG1846	Transcriptional regulator
HC660_02540	COG2271	Major facilitator Superfamily
HC660_02570	COG0371	Dehydrogenase
HC660_02580	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HC660_02590	COG3591	Belongs to the peptidase S1B family
HC660_02610	COG0596	Alpha beta hydrolase
HC660_02620	COG1183	phosphatidylcholine synthase activity
HC660_02630	COG0586	Pfam SNARE associated Golgi protein
HC660_02640	COG0688	phosphatidylethanolamine metabolic process
HC660_02660	COG2312	Erythromycin esterase
HC660_02670	COG2207	Transcriptional regulator
HC660_02690	COG1301	dicarboxylic acid transport
HC660_02700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC660_02700	COG1263	PTS System
HC660_02700	COG2190	(PTS) system
HC660_02710	COG0363	glucosamine-6-phosphate deaminase activity
HC660_02720	COG2188	Transcriptional regulator
HC660_02740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC660_02750	COG0833	amino acid
HC660_02760	COG2040	homocysteine
HC660_02770	COG1115	amino acid carrier protein
HC660_02780	COG2066	Belongs to the glutaminase family
HC660_02790	COG4191	Histidine kinase
HC660_02800	COG0784	Response regulator, receiver
HC660_02810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC660_02820	COG1012	belongs to the aldehyde dehydrogenase family
HC660_02830	COG2271	Major facilitator Superfamily
HC660_02840	COG4948	Mandelate Racemase Muconate Lactonizing
HC660_02850	COG2186	Transcriptional regulator
HC660_02860	COG2721	sulfolactate sulfo-lyase activity
HC660_02870	COG3173	Aminoglycoside phosphotransferase
HC660_02890	COG0745	RESPONSE REGULATOR receiver
HC660_02900	COG2205	protein histidine kinase activity
HC660_02910	COG1131	(ABC) transporter
HC660_02950	COG3773	Cell wall hydrolase
HC660_02960	COG2304	oxidoreductase activity
HC660_02970	COG3540	Alkaline phosphatase
HC660_02980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC660_02990	COG0805	protein transport
HC660_03000	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HC660_03010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC660_03020	COG0477	Major facilitator Superfamily
HC660_03030	COG1309	transcriptional regulator
HC660_03040	COG0252	asparaginase activity
HC660_03050	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC660_03060	COG1714	RDD family
HC660_03070	COG1405	negative regulation of cell septum assembly
HC660_03070	COG3012	SEC-C Motif Domain Protein
HC660_03080	COG3290	protein histidine kinase activity
HC660_03090	COG3279	Response regulator of the LytR AlgR family
HC660_03100	COG4555	ABC transporter
HC660_03110	COG1668	transmembrane transport
HC660_03120	COG0667	Aldo Keto reductase
HC660_03140	COG1595	DNA-templated transcription, initiation
HC660_03150	COG1595	DNA-templated transcription, initiation
HC660_03160	COG1876	peptidase activity
HC660_03170	COG0457	Tetratricopeptide repeat
HC660_03180	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_03190	COG0366	Alpha amylase catalytic
HC660_03200	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC660_03210	COG1121	(ABC) transporter
HC660_03220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC660_03230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC660_03240	COG2310	stress, protein
HC660_03250	COG2310	stress, protein
HC660_03260	COG2310	stress, protein
HC660_03270	COG0861	Integral membrane protein TerC family
HC660_03300	COG1358	cellular component organization or biogenesis
HC660_03330	COG3853	Toxic anion resistance protein (TelA)
HC660_03340	COG0477	Major facilitator Superfamily
HC660_03350	COG4175	Glycine betaine
HC660_03350	COG0517	IMP dehydrogenase activity
HC660_03360	COG4176	ABC-type proline glycine betaine transport system permease component
HC660_03370	COG2113	Glycine betaine
HC660_03380	COG1473	amidohydrolase
HC660_03390	COG1288	antiporter activity
HC660_03410	COG0039	L-malate dehydrogenase activity
HC660_03420	COG1620	l-lactate permease
HC660_03430	COG2814	Major facilitator Superfamily
HC660_03440	COG1846	Transcriptional regulator
HC660_03450	COG1280	lysine exporter protein (LysE YggA)
HC660_03460	COG3403	YqcI/YcgG family
HC660_03470	COG1113	amino acid transport
HC660_03480	COG3665	Urea carboxylase-associated protein
HC660_03490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HC660_03500	COG1660	Displays ATPase and GTPase activities
HC660_03510	COG1082	Xylose isomerase domain protein TIM barrel
HC660_03520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC660_03530	COG0583	DNA-binding transcription factor activity
HC660_03540	COG0583	DNA-binding transcription factor activity
HC660_03550	COG3458	cephalosporin-C deacetylase activity
HC660_03560	COG3541	Predicted nucleotidyltransferase
HC660_03570	COG0506	proline dehydrogenase activity
HC660_03580	COG1012	belongs to the aldehyde dehydrogenase family
HC660_03590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC660_03600	COG2508	Transcriptional regulator
HC660_03610	COG3689	TIGRFAM TIGR03943 family protein
HC660_03620	COG0701	Predicted permease
HC660_03630	COG2267	carboxylic ester hydrolase activity
HC660_03640	COG0492	ferredoxin-NADP+ reductase activity
HC660_03650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC660_03650	COG1587	Uroporphyrinogen-III synthase
HC660_03660	COG2146	nitrite reductase [NAD(P)H] activity
HC660_03670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC660_03680	COG0243	molybdopterin cofactor binding
HC660_03690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC660_03700	COG2223	nitrite transmembrane transporter activity
HC660_03710	COG1469	GTP cyclohydrolase I activity
HC660_03720	COG0457	Tetratricopeptide repeat
HC660_03740	COG0523	cobalamin synthesis protein
HC660_03750	COG0765	amino acid transport
HC660_03760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC660_03770	COG1714	RDD family
HC660_03790	COG1846	Transcriptional regulator
HC660_03800	COG3842	ATPase activity
HC660_03810	COG2723	6-phospho-beta-galactosidase activity
HC660_03830	COG3209	COG3209 Rhs family protein
HC660_03840	COG3290	protein histidine kinase activity
HC660_03840	COG0840	transmembrane signaling receptor activity
HC660_03850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HC660_03860	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HC660_03870	COG1733	regulation of RNA biosynthetic process
HC660_03880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC660_03890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC660_03900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC660_03910	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HC660_03920	COG2814	Major facilitator Superfamily
HC660_03940	COG0697	spore germination
HC660_03950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC660_03980	COG0701	Predicted permease
HC660_03990	COG2364	Membrane
HC660_04000	COG1126	abc transporter atp-binding protein
HC660_04010	COG0765	amino acid transport
HC660_04020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC660_04030	COG0583	DNA-binding transcription factor activity
HC660_04040	COG0163	prenyltransferase activity
HC660_04050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC660_04080	COG0596	Alpha beta hydrolase
HC660_04090	COG3104	oligopeptide transport
HC660_04100	COG5434	Belongs to the glycosyl hydrolase 28 family
HC660_04120	COG0697	spore germination
HC660_04140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC660_04150	COG1136	(ABC) transporter
HC660_04160	COG0577	efflux transmembrane transporter activity
HC660_04170	COG0745	RESPONSE REGULATOR receiver
HC660_04180	COG5002	protein histidine kinase activity
HC660_04180	COG3850	Histidine kinase
HC660_04190	COG0457	Tetratricopeptide repeat
HC660_04210	COG0527	aspartate kinase activity
HC660_04220	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC660_04230	COG4605	iron ion homeostasis
HC660_04240	COG4604	ABC transporter, ATP-binding protein
HC660_04250	COG4607	ABC-type enterochelin transport system periplasmic component
HC660_04260	COG2814	Major facilitator Superfamily
HC660_04270	COG1309	transcriptional regulator
HC660_04280	COG0778	Nitroreductase
HC660_04290	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC660_04300	COG0640	Transcriptional regulator
HC660_04310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC660_04320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC660_04330	COG1012	belongs to the aldehyde dehydrogenase family
HC660_04340	COG4975	Glucose uptake
HC660_04350	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_04360	COG4549	nuclear export factor GLE1
HC660_04370	COG1276	copper resistance
HC660_04370	COG2372	response to copper ion
HC660_04380	COG1349	DNA-binding transcription factor activity
HC660_04400	COG2213	PTS system mannitol-specific
HC660_04410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC660_04420	COG0246	Mannitol dehydrogenase
HC660_04430	COG0473	3-isopropylmalate dehydrogenase activity
HC660_04440	COG0681	Belongs to the peptidase S26 family
HC660_04450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC660_04470	COG0561	phosphatase activity
HC660_04480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HC660_04490	COG1914	H( )-stimulated, divalent metal cation uptake system
HC660_04500	COG4336	lyase activity
HC660_04510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HC660_04520	COG1984	allophanate hydrolase subunit 2
HC660_04530	COG1414	Transcriptional regulator
HC660_04540	COG2755	lipolytic protein G-D-S-L family
HC660_04560	COG2329	Antibiotic biosynthesis monooxygenase
HC660_04570	COG0768	penicillin binding
HC660_04580	COG4989	oxidoreductase activity
HC660_04590	COG3711	transcriptional antiterminator
HC660_04600	COG0318	PFAM AMP-dependent synthetase and ligase
HC660_04610	COG2226	methyltransferase
HC660_04620	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_04630	COG1917	Cupin 2, conserved barrel domain protein
HC660_04640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC660_04650	COG3871	stress protein (general stress protein 26)
HC660_04670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC660_04680	COG2814	Major facilitator Superfamily
HC660_04690	COG1522	sequence-specific DNA binding
HC660_04700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC660_04700	COG0551	DNA topoisomerase type I activity
HC660_04710	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HC660_04720	COG3706	GGDEF domain
HC660_04730	COG5298	Protein conserved in bacteria
HC660_04740	COG1215	transferase activity, transferring glycosyl groups
HC660_04760	COG0531	amino acid
HC660_04770	COG0494	nUDIX hydrolase
HC660_04780	COG0028	Belongs to the TPP enzyme family
HC660_04800	COG1914	H( )-stimulated, divalent metal cation uptake system
HC660_04810	COG2261	transglycosylase associated protein
HC660_04820	COG4876	unkown
HC660_04830	COG2217	Heavy metal translocating P-type atpase
HC660_04840	COG3729	General stress protein
HC660_04850	COG0662	Cupin 2, conserved barrel domain protein
HC660_04860	COG2329	Antibiotic biosynthesis monooxygenase
HC660_04880	COG3546	catalase activity
HC660_04890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HC660_04900	COG3290	protein histidine kinase activity
HC660_04910	COG4565	transcriptional regulatory protein
HC660_04920	COG1301	dicarboxylic acid transport
HC660_04930	COG0628	permease
HC660_04940	COG1301	dicarboxylic acid transport
HC660_04950	COG1131	(ABC) transporter
HC660_04960	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC660_04980	COG1960	acyl-CoA dehydrogenase activity
HC660_05010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC660_05020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC660_05030	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC660_05040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC660_05050	COG0513	Belongs to the DEAD box helicase family
HC660_05060	COG3402	PFAM membrane-flanked domain
HC660_05070	COG3428	Bacterial PH domain
HC660_05080	COG0705	Rhomboid family
HC660_05090	COG0736	holo-[acyl-carrier-protein] synthase activity
HC660_05100	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HC660_05110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC660_05120	COG0864	Transcriptional regulator
HC660_05130	COG2337	Toxic component of a toxin-antitoxin (TA) module
HC660_05140	COG1366	Belongs to the anti-sigma-factor antagonist family
HC660_05150	COG1366	Belongs to the anti-sigma-factor antagonist family
HC660_05160	COG2172	sigma factor antagonist activity
HC660_05170	COG2208	phosphoserine phosphatase activity
HC660_05180	COG1366	Belongs to the anti-sigma-factor antagonist family
HC660_05190	COG2172	sigma factor antagonist activity
HC660_05200	COG1191	sigma factor activity
HC660_05210	COG2208	phosphoserine phosphatase activity
HC660_05220	COG2183	response to ionizing radiation
HC660_05230	COG3091	SprT-like family
HC660_05330	COG1191	sigma factor activity
HC660_05350	COG0582	viral genome integration into host DNA
HC660_05360	COG1396	sequence-specific DNA binding
HC660_05410	COG1674	ftsk spoiiie
HC660_05420	COG2946	Replication initiation factor
HC660_05490	COG0433	COG0433 Predicted ATPase
HC660_05510	COG5644	endopeptidase inhibitor activity
HC660_05520	COG0741	lytic transglycosylase activity
HC660_05520	COG0791	NLP P60 protein
HC660_05550	COG0457	Tetratricopeptide repeat
HC660_05580	COG1401	restriction endodeoxyribonuclease activity
HC660_05590	COG1802	Transcriptional regulator
HC660_05600	COG5444	nuclease activity
HC660_05610	COG0741	lytic transglycosylase activity
HC660_05610	COG0791	NLP P60 protein
HC660_05620	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC660_05630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC660_05640	COG1522	sequence-specific DNA binding
HC660_05650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC660_05660	COG2814	Major facilitator Superfamily
HC660_05680	COG3239	Fatty acid desaturase
HC660_05690	COG1329	Transcriptional regulator
HC660_05700	COG0346	lactoylglutathione lyase activity
HC660_05720	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HC660_05740	COG2364	Membrane
HC660_05750	COG1846	Transcriptional regulator
HC660_05760	COG0456	acetyltransferase
HC660_05770	COG2808	Putative FMN-binding domain
HC660_05780	COG0697	spore germination
HC660_05790	COG0693	protein deglycase activity
HC660_05800	COG0697	spore germination
HC660_05810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC660_05820	COG0640	Transcriptional regulator
HC660_05830	COG0346	lactoylglutathione lyase activity
HC660_05840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC660_05860	COG0456	acetyltransferase
HC660_05870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC660_05870	COG3711	transcriptional antiterminator
HC660_05880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC660_05880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC660_05880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC660_05890	COG1482	cell wall glycoprotein biosynthetic process
HC660_05900	COG2030	dehydratase
HC660_05910	COG0697	spore germination
HC660_05920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC660_05930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC660_05940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC660_05950	COG0778	Nitroreductase
HC660_05960	COG0346	lactoylglutathione lyase activity
HC660_05970	COG2259	Doxx family
HC660_05980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC660_05990	COG0456	acetyltransferase
HC660_06010	COG1113	amino acid transport
HC660_06020	COG2318	DinB family
HC660_06030	COG1846	Transcriptional regulator
HC660_06040	COG1033	growth of symbiont in host cell
HC660_06040	COG2409	Drug exporters of the RND superfamily
HC660_06060	COG0778	Nitroreductase
HC660_06070	COG1846	Transcriptional regulator
HC660_06080	COG1396	sequence-specific DNA binding
HC660_06100	COG2814	Major facilitator Superfamily
HC660_06110	COG0730	response to heat
HC660_06120	COG1802	Transcriptional regulator
HC660_06130	COG1388	LysM domain
HC660_06130	COG3858	chitin binding
HC660_06140	COG1819	glycosyl
HC660_06170	COG1785	Belongs to the alkaline phosphatase family
HC660_06180	COG1078	dGTPase activity
HC660_06190	COG1388	LysM domain
HC660_06200	COG2814	Major facilitator Superfamily
HC660_06210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC660_06220	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC660_06230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC660_06240	COG2723	6-phospho-beta-galactosidase activity
HC660_06250	COG2188	Transcriptional regulator
HC660_06260	COG1940	carbohydrate kinase activity
HC660_06270	COG1482	cell wall glycoprotein biosynthetic process
HC660_06280	COG4124	Belongs to the glycosyl hydrolase 26 family
HC660_06370	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HC660_06380	COG0802	atpase or kinase
HC660_06390	COG1214	PFAM Peptidase M22, glycoprotease
HC660_06400	COG0456	acetyltransferase
HC660_06410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HC660_06420	COG0488	(ABC) transporter
HC660_06430	COG0315	cyclic pyranopterin monophosphate synthase activity
HC660_06440	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HC660_06450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC660_06460	COG0805	protein transport
HC660_06480	COG1266	CAAX protease self-immunity
HC660_06510	COG1073	alpha beta
HC660_06520	COG0457	Tetratricopeptide repeat
HC660_06530	COG1063	alcohol dehydrogenase
HC660_06540	COG2211	Major facilitator Superfamily
HC660_06550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC660_06570	COG2814	Major facilitator Superfamily
HC660_06580	COG1063	alcohol dehydrogenase
HC660_06590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HC660_06600	COG0823	Involved in the tonB-independent uptake of proteins
HC660_06630	COG2267	carboxylic ester hydrolase activity
HC660_06650	COG2132	Multicopper oxidase
HC660_06660	COG1113	amino acid transport
HC660_06670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC660_06680	COG0714	Associated with various cellular activities
HC660_06690	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HC660_06700	COG1305	Transglutaminase-like
HC660_06710	COG0519	Catalyzes the synthesis of GMP from XMP
HC660_06710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC660_06720	COG2252	PERMEase
HC660_06730	COG3064	Membrane
HC660_06750	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HC660_06770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC660_06780	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HC660_06790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC660_06800	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HC660_06810	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC660_06820	COG0047	phosphoribosylformylglycinamidine synthase activity
HC660_06830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC660_06840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HC660_06850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HC660_06860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC660_06870	COG0138	bifunctional purine biosynthesis protein purh
HC660_06880	COG0151	Belongs to the GarS family
HC660_06890	COG1522	sequence-specific DNA binding
HC660_06900	COG0531	amino acid
HC660_06920	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC660_06930	COG1470	cell adhesion involved in biofilm formation
HC660_06940	COG4496	protein, YerC YecD
HC660_06950	COG0069	glutamate synthase activity
HC660_06960	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HC660_06970	COG0210	DNA helicase
HC660_06980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HC660_06990	COG4851	CamS sex pheromone cAM373 precursor
HC660_07000	COG2211	Major facilitator Superfamily
HC660_07030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC660_07040	COG1285	pathogenesis
HC660_07050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC660_07060	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC660_07070	COG0154	amidase activity
HC660_07080	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC660_07090	COG1309	transcriptional regulator
HC660_07100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC660_07110	COG1597	lipid kinase activity
HC660_07120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC660_07160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HC660_07210	COG0457	Tetratricopeptide repeat
HC660_07250	COG5444	nuclease activity
HC660_07260	COG3391	amine dehydrogenase activity
HC660_07270	COG0457	Tetratricopeptide repeat
HC660_07290	COG0217	transcriptional regulatory protein
HC660_07310	COG1309	transcriptional regulator
HC660_07320	COG3631	Ketosteroid isomerase-related protein
HC660_07330	COG0702	epimerase
HC660_07340	COG2159	amidohydrolase
HC660_07350	COG1309	transcriptional regulator
HC660_07380	COG3546	catalase activity
HC660_07390	COG0454	-acetyltransferase
HC660_07410	COG5578	integral membrane protein
HC660_07420	COG2972	Histidine kinase
HC660_07430	COG2207	Transcriptional regulator
HC660_07430	COG4753	response regulator
HC660_07440	COG1653	transport
HC660_07450	COG1175	transmembrane transport
HC660_07460	COG0395	ABC-type sugar transport system, permease component
HC660_07470	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC660_07480	COG2207	Transcriptional regulator
HC660_07490	COG2755	lipolytic protein G-D-S-L family
HC660_07510	COG5578	integral membrane protein
HC660_07520	COG3401	FG-GAP repeat protein
HC660_07530	COG3401	FG-GAP repeat protein
HC660_07540	COG0667	Aldo Keto reductase
HC660_07550	COG2755	lipolytic protein G-D-S-L family
HC660_07560	COG1874	Beta-galactosidase
HC660_07580	COG1653	transport
HC660_07590	COG4209	transmembrane transport
HC660_07600	COG0395	ABC-type sugar transport system, permease component
HC660_07610	COG1486	melibiose metabolic process
HC660_07620	COG2323	membrane
HC660_07630	COG2329	Antibiotic biosynthesis monooxygenase
HC660_07650	COG1366	Belongs to the anti-sigma-factor antagonist family
HC660_07660	COG5583	Uncharacterized small protein (DUF2292)
HC660_07670	COG0670	Belongs to the BI1 family
HC660_07680	COG1846	Transcriptional regulator
HC660_07690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC660_07720	COG2124	cytochrome p450
HC660_07720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC660_07730	COG1368	sulfuric ester hydrolase activity
HC660_07740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HC660_07750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC660_07760	COG1442	glycosyl transferase family 8
HC660_07770	COG1216	Glycosyl transferase, family 2
HC660_07780	COG1442	glycosyl transferase family 8
HC660_07790	COG2223	nitrite transmembrane transporter activity
HC660_07800	COG1011	Hydrolase
HC660_07810	COG0531	amino acid
HC660_07820	COG1012	belongs to the aldehyde dehydrogenase family
HC660_07830	COG0840	transmembrane signaling receptor activity
HC660_07840	COG0488	(ABC) transporter
HC660_07860	COG0789	Transcriptional regulator
HC660_07870	COG2814	Major facilitator Superfamily
HC660_07900	COG0488	(ABC) transporter
HC660_07910	COG0513	Belongs to the DEAD box helicase family
HC660_07920	COG0456	acetyltransferase
HC660_07930	COG2130	NADP-dependent
HC660_07940	COG1120	ATPase activity
HC660_07950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC660_07960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC660_07970	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC660_08000	COG3866	Pectate lyase
HC660_08010	COG0471	metal ion transport
HC660_08050	COG0463	Glycosyl transferase, family 2
HC660_08070	COG3290	protein histidine kinase activity
HC660_08080	COG4565	transcriptional regulatory protein
HC660_08090	COG3181	Tripartite tricarboxylate transporter family receptor
HC660_08100	COG2851	Citrate transporter
HC660_08110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC660_08120	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HC660_08130	COG1254	Belongs to the acylphosphatase family
HC660_08140	COG2258	MOSC domain
HC660_08180	COG0024	Methionine aminopeptidase
HC660_08190	COG1263	PTS System
HC660_08190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC660_08200	COG1368	sulfuric ester hydrolase activity
HC660_08220	COG1115	amino acid carrier protein
HC660_08230	COG1263	PTS System
HC660_08230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC660_08240	COG0366	Alpha amylase catalytic
HC660_08250	COG2188	Transcriptional regulator
HC660_08260	COG0778	Nitroreductase
HC660_08270	COG0737	Belongs to the 5'-nucleotidase family
HC660_08280	COG0693	protein deglycase activity
HC660_08290	COG2814	Major facilitator Superfamily
HC660_08300	COG4840	Belongs to the UPF0435 family
HC660_08310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC660_08320	COG4980	gas vesicle protein
HC660_08330	COG1295	ribonuclease BN
HC660_08340	COG0477	Major facilitator Superfamily
HC660_08350	COG0387	Pfam Sodium calcium exchanger
HC660_08370	COG0668	transmembrane transport
HC660_08380	COG0535	radical SAM domain protein
HC660_08400	COG0726	polysaccharide deacetylase
HC660_08410	COG2084	Dehydrogenase
HC660_08420	COG0598	Magnesium transport protein CorA
HC660_08430	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC660_08440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC660_08450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC660_08460	COG4637	Psort location Cytoplasmic, score
HC660_08470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC660_08480	COG0022	dehydrogenase e1 component
HC660_08490	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC660_08500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC660_08510	COG3284	Transcriptional regulator
HC660_08530	COG1742	UPF0060 membrane protein
HC660_08570	COG4842	Belongs to the WXG100 family
HC660_08580	COG1486	melibiose metabolic process
HC660_08590	COG1737	Transcriptional regulator
HC660_08600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC660_08600	COG1263	PTS System
HC660_08610	COG1132	(ABC) transporter
HC660_08620	COG1132	(ABC) transporter
HC660_08630	COG2259	Doxx family
HC660_08640	COG2514	catechol 2,3-dioxygenase activity
HC660_08650	COG4585	Histidine kinase
HC660_08660	COG2197	response regulator
HC660_08670	COG1131	(ABC) transporter
HC660_08680	COG0842	Transport permease protein
HC660_08680	COG1511	domain protein
HC660_08690	COG0842	Transport permease protein
HC660_08700	COG1695	Transcriptional regulator
HC660_08710	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC660_08720	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HC660_08730	COG2318	DinB family
HC660_08740	COG2814	Major facilitator Superfamily
HC660_08750	COG1846	Transcriptional regulator
HC660_08760	COG0392	lysyltransferase activity
HC660_08760	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HC660_08770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC660_08780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC660_08790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC660_08800	COG0384	phenazine biosynthesis protein PhzF
HC660_08810	COG0778	Nitroreductase
HC660_08840	COG1090	epimerase
HC660_08850	COG2137	regulation of response to DNA damage stimulus
HC660_08870	COG2814	Major facilitator Superfamily
HC660_08900	COG3103	Sh3 type 3 domain protein
HC660_08910	COG5658	integral membrane protein
HC660_08920	COG0596	Alpha beta hydrolase
HC660_08930	COG0463	Glycosyl transferase, family 2
HC660_08940	COG4485	Bacterial membrane protein, YfhO
HC660_08950	COG1988	membrane-bound metal-dependent
HC660_08960	COG1194	a g-specific adenine glycosylase
HC660_08980	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_09010	COG3557	Belongs to the UPF0374 family
HC660_09020	COG1132	(ABC) transporter
HC660_09030	COG4129	membrane
HC660_09040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC660_09050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HC660_09060	COG0735	belongs to the Fur family
HC660_09310	COG4326	sporulation control protein
HC660_09330	COG1063	alcohol dehydrogenase
HC660_09340	COG5577	PFAM Coat F domain
HC660_09360	COG3340	Belongs to the peptidase S51 family
HC660_09370	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HC660_09390	COG0753	catalase activity
HC660_09400	COG1116	anion transmembrane transporter activity
HC660_09410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC660_09420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC660_09430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC660_09450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC660_09470	COG1476	TRANSCRIPTIONal
HC660_09490	COG3382	B3 4 domain protein
HC660_09500	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HC660_09520	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC660_09530	COG0789	Transcriptional regulator
HC660_09540	COG1664	Polymer-forming cytoskeletal
HC660_09550	COG1664	Polymer-forming cytoskeletal
HC660_09560	COG2766	serine protein kinase
HC660_09570	COG2718	Belongs to the UPF0229 family
HC660_09580	COG1846	Transcriptional regulator
HC660_09590	COG1566	PFAM secretion protein HlyD family protein
HC660_09600	COG2814	Major facilitator Superfamily
HC660_09610	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC660_09640	COG1725	Transcriptional regulator
HC660_09650	COG1131	(ABC) transporter
HC660_09660	COG1131	(ABC) transporter
HC660_09670	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC660_09680	COG1278	Cold shock
HC660_09690	COG1464	Belongs to the NlpA lipoprotein family
HC660_09700	COG3706	GGDEF domain
HC660_09710	COG1823	symporter activity
HC660_09720	COG1309	transcriptional regulator
HC660_09730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC660_09770	COG1525	nuclease
HC660_09770	COG4085	toxin activity
HC660_09770	COG0737	Belongs to the 5'-nucleotidase family
HC660_09780	COG3764	Sortase (surface protein transpeptidase)
HC660_09790	COG0564	pseudouridine synthase activity
HC660_09810	COG0517	IMP dehydrogenase activity
HC660_09820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC660_09830	COG3153	acetyltransferase
HC660_09830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC660_09850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC660_09860	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HC660_09870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC660_09880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC660_09890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC660_09900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC660_09910	COG2203	Gaf domain
HC660_09910	COG4585	Histidine kinase
HC660_09920	COG2197	response regulator
HC660_09930	COG0431	NADPH-dependent FMN reductase
HC660_09960	COG1388	LysM domain
HC660_09960	COG0791	NLP P60 protein
HC660_09970	COG1959	2 iron, 2 sulfur cluster binding
HC660_09980	COG2719	SpoVR family
HC660_09990	COG1785	Belongs to the alkaline phosphatase family
HC660_10000	COG1388	LysM domain
HC660_10000	COG0791	NLP P60 protein
HC660_10010	COG0583	DNA-binding transcription factor activity
HC660_10020	COG0372	Belongs to the citrate synthase family
HC660_10030	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_10040	COG0531	amino acid
HC660_10050	COG0733	neurotransmitter:sodium symporter activity
HC660_10060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC660_10070	COG0456	acetyltransferase
HC660_10100	COG1595	DNA-templated transcription, initiation
HC660_10110	COG0667	Aldo Keto reductase
HC660_10120	COG0204	Acyl-transferase
HC660_10130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC660_10140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC660_10150	COG1253	flavin adenine dinucleotide binding
HC660_10160	COG0789	Transcriptional regulator
HC660_10170	COG0436	Aminotransferase
HC660_10180	COG1253	flavin adenine dinucleotide binding
HC660_10190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC660_10200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC660_10210	COG0584	glycerophosphoryl diester phosphodiesterase
HC660_10230	COG0668	transmembrane transport
HC660_10240	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HC660_10250	COG0726	polysaccharide deacetylase
HC660_10260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC660_10270	COG1757	Na H antiporter
HC660_10280	COG0589	response to stress
HC660_10290	COG1132	(ABC) transporter
HC660_10300	COG1132	(ABC) transporter
HC660_10310	COG0702	epimerase
HC660_10340	COG0189	ligase activity
HC660_10350	COG0189	ligase activity
HC660_10360	COG4399	Belongs to the UPF0754 family
HC660_10370	COG3679	Belongs to the UPF0342 family
HC660_10380	COG4335	DNA alkylation repair
HC660_10390	COG0561	phosphatase activity
HC660_10400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC660_10410	COG0475	glutathione-regulated potassium exporter activity
HC660_10420	COG0490	domain, Protein
HC660_10440	COG1024	Enoyl-CoA hydratase
HC660_10460	COG4152	abc transporter atp-binding protein
HC660_10470	COG1668	transmembrane transport
HC660_10480	COG0420	3'-5' exonuclease activity
HC660_10490	COG4717	serine-type aminopeptidase activity
HC660_10500	COG3481	metal-dependent phosphohydrolase, HD sub domain
HC660_10520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC660_10550	COG1846	Transcriptional regulator
HC660_10560	COG4980	gas vesicle protein
HC660_10590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HC660_10600	COG0537	adenosine 5'-monophosphoramidase activity
HC660_10610	COG1131	(ABC) transporter
HC660_10620	COG4473	ABC transporter
HC660_10640	COG1473	amidohydrolase
HC660_10650	COG3069	C4-dicarboxylate transmembrane transporter activity
HC660_10670	COG2329	Antibiotic biosynthesis monooxygenase
HC660_10680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC660_10690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HC660_10720	COG1309	transcriptional regulator
HC660_10730	COG1511	domain protein
HC660_10740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC660_10750	COG4377	Putative membrane peptidase family (DUF2324)
HC660_10760	COG1363	Peptidase, m42
HC660_10770	COG4405	Protein conserved in bacteria
HC660_10780	COG1301	dicarboxylic acid transport
HC660_10800	COG1234	tRNA 3'-trailer cleavage
HC660_10810	COG0095	Lipoate-protein ligase
HC660_10820	COG0702	epimerase
HC660_10830	COG0318	PFAM AMP-dependent synthetase and ligase
HC660_10850	COG0501	Belongs to the peptidase M48B family
HC660_10860	COG1404	Belongs to the peptidase S8 family
HC660_10870	COG0456	acetyltransferase
HC660_10880	COG0604	alcohol dehydrogenase
HC660_10890	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC660_10900	COG0406	alpha-ribazole phosphatase activity
HC660_10910	COG0183	Belongs to the thiolase family
HC660_10920	COG0318	PFAM AMP-dependent synthetase and ligase
HC660_10930	COG1268	BioY protein
HC660_10940	COG0840	transmembrane signaling receptor activity
HC660_10950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC660_10950	COG0723	plastoquinol--plastocyanin reductase activity
HC660_10960	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_10980	COG4903	ComK protein
HC660_10990	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_11010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC660_11040	COG0398	Pfam SNARE associated Golgi protein
HC660_11050	COG0681	Belongs to the peptidase S26 family
HC660_11060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC660_11070	COG1846	Transcriptional regulator
HC660_11080	COG0738	Major facilitator superfamily
HC660_11090	COG0673	inositol 2-dehydrogenase activity
HC660_11100	COG0561	phosphatase activity
HC660_11110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC660_11120	COG1609	Transcriptional regulator
HC660_11130	COG3180	Ammonia monooxygenase
HC660_11140	COG0477	Major facilitator Superfamily
HC660_11140	COG2814	Major facilitator Superfamily
HC660_11150	COG4533	DNA binding
HC660_11170	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HC660_11180	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HC660_11190	COG1074	ATP-dependent DNA helicase activity
HC660_11200	COG0420	3'-5' exonuclease activity
HC660_11210	COG0419	ATPase involved in DNA repair
HC660_11220	COG1403	HNH endonuclease
HC660_11300	COG5337	Spore coat protein CotH
HC660_11310	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC660_11330	COG1404	Belongs to the peptidase S8 family
HC660_11350	COG0367	asparagine synthase
HC660_11360	COG1562	ergosterol biosynthetic process
HC660_11370	COG0534	Mate efflux family protein
HC660_11380	COG2207	Transcriptional regulator
HC660_11380	COG1917	Cupin 2, conserved barrel domain protein
HC660_11390	COG1609	Transcriptional regulator
HC660_11400	COG0673	inositol 2-dehydrogenase activity
HC660_11410	COG2318	DinB family
HC660_11420	COG1279	arginine transmembrane transporter activity
HC660_11430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC660_11440	COG1357	PFAM Pentapeptide repeats (8 copies)
HC660_11450	COG2267	carboxylic ester hydrolase activity
HC660_11460	COG0529	Catalyzes the synthesis of activated sulfate
HC660_11470	COG2046	Belongs to the sulfate adenylyltransferase family
HC660_11480	COG0175	sulfate reduction
HC660_11490	COG2045	Belongs to the ComB family
HC660_11500	COG1809	phosphosulfolactate synthase activity
HC660_11510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC660_11520	COG4948	Mandelate Racemase Muconate Lactonizing
HC660_11530	COG2814	Major facilitator Superfamily
HC660_11540	COG0454	-acetyltransferase
HC660_11550	COG2153	protein acetylation
HC660_11560	COG0646	methionine synthase
HC660_11560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HC660_11570	COG1666	GTP binding
HC660_11580	COG2996	Protein conserved in bacteria
HC660_11620	COG1695	Transcriptional regulator
HC660_11650	COG3227	Zinc metalloprotease (Elastase)
HC660_11660	COG1307	EDD domain protein, DegV family
HC660_11670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC660_11700	COG0561	phosphatase activity
HC660_11710	COG1073	alpha beta
HC660_11720	COG2151	metal-sulfur cluster biosynthetic enzyme
HC660_11740	COG0277	FAD linked oxidase domain protein
HC660_11750	COG2271	Major facilitator Superfamily
HC660_11760	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HC660_11770	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HC660_11790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC660_11800	COG0505	Belongs to the CarA family
HC660_11810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC660_11820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HC660_11850	COG2267	carboxylic ester hydrolase activity
HC660_11870	COG1744	ABC transporter substrate-binding protein PnrA-like
HC660_11900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC660_11910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC660_11920	COG5504	Zn-dependent protease
HC660_11930	COG0444	Belongs to the ABC transporter superfamily
HC660_11940	COG4608	Belongs to the ABC transporter superfamily
HC660_11960	COG0601	transmembrane transport
HC660_11970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC660_11990	COG0180	Tryptophanyl-tRNA synthetase
HC660_12000	COG4166	transmembrane transport
HC660_12010	COG0601	transmembrane transport
HC660_12020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC660_12030	COG0444	Belongs to the ABC transporter superfamily
HC660_12040	COG4608	Belongs to the ABC transporter superfamily
HC660_12050	COG2814	Major facilitator Superfamily
HC660_12060	COG0456	acetyltransferase
HC660_12070	COG1393	Belongs to the ArsC family
HC660_12080	COG0861	Integral membrane protein TerC family
HC660_12090	COG4862	establishment of competence for transformation
HC660_12100	COG4469	Competence protein
HC660_12110	COG1164	Oligoendopeptidase f
HC660_12140	COG2346	COG2346, Truncated hemoglobins
HC660_12150	COG0741	lytic transglycosylase activity
HC660_12160	COG4116	CYTH
HC660_12180	COG2357	RelA SpoT domain protein
HC660_12190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC660_12200	COG0564	pseudouridine synthase activity
HC660_12210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HC660_12220	COG0475	glutathione-regulated potassium exporter activity
HC660_12220	COG0569	domain protein
HC660_12230	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HC660_12240	COG0352	thiamine-phosphate diphosphorylase activity
HC660_12250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC660_12260	COG2104	thiamine diphosphate biosynthetic process
HC660_12270	COG2022	thiamine diphosphate biosynthetic process
HC660_12280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC660_12290	COG0351	phosphomethylpyrimidine kinase
HC660_12300	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC660_12410	COG0210	DNA helicase
HC660_12430	COG2153	protein acetylation
HC660_12440	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC660_12450	COG2382	esterase
HC660_12460	COG0626	cystathionine gamma-synthase activity
HC660_12470	COG0626	cystathionine gamma-synthase activity
HC660_12480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC660_12490	COG5505	Protein of unknown function (DUF819)
HC660_12520	COG5444	nuclease activity
HC660_12550	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC660_12570	COG2318	DinB family
HC660_12620	COG3409	Peptidoglycan-binding domain 1 protein
HC660_12650	COG0583	DNA-binding transcription factor activity
HC660_12660	COG0697	spore germination
HC660_12670	COG0789	Transcriptional regulator
HC660_12710	COG0109	protoheme IX farnesyltransferase activity
HC660_12730	COG0726	polysaccharide deacetylase
HC660_12760	COG5504	Zn-dependent protease
HC660_12770	COG2205	protein histidine kinase activity
HC660_12790	COG3383	formate dehydrogenase (NAD+) activity
HC660_12800	COG2427	Protein of unknown function (DUF1641)
HC660_12820	COG1051	belongs to the nudix hydrolase family
HC660_12830	COG2124	cytochrome p450
HC660_12840	COG1819	glycosyl
HC660_12850	COG1587	Uroporphyrinogen-III synthase
HC660_12860	COG0390	transport system, permease component
HC660_12870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC660_12880	COG0697	spore germination
HC660_12890	COG4297	protein containing double-stranded beta helix domain
HC660_12910	COG1252	NADH dehydrogenase
HC660_12920	COG1904	glucuronate isomerase
HC660_12930	COG2211	Major facilitator Superfamily
HC660_12940	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HC660_12950	COG1063	alcohol dehydrogenase
HC660_12960	COG1312	Catalyzes the dehydration of D-mannonate
HC660_12970	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_12980	COG2271	Major facilitator Superfamily
HC660_12990	COG1609	Transcriptional regulator
HC660_13000	COG0246	Mannitol dehydrogenase
HC660_13010	COG2721	sulfolactate sulfo-lyase activity
HC660_13020	COG0730	response to heat
HC660_13030	COG2318	DinB family
HC660_13040	COG0457	Tetratricopeptide repeat
HC660_13060	COG1388	LysM domain
HC660_13060	COG3409	Peptidoglycan-binding domain 1 protein
HC660_13060	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC660_13090	COG4195	phage-related replication protein
HC660_13100	COG3546	catalase activity
HC660_13110	COG2856	Zn peptidase
HC660_13120	COG1396	sequence-specific DNA binding
HC660_13140	COG1522	sequence-specific DNA binding
HC660_13150	COG1484	DNA-dependent DNA replication
HC660_13190	COG1595	DNA-templated transcription, initiation
HC660_13200	COG3728	DNA packaging
HC660_13200	COG5484	DNA packaging
HC660_13210	COG1783	phage Terminase large subunit
HC660_13220	COG5518	Phage portal protein
HC660_13230	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC660_13240	COG4653	Phage capsid family
HC660_13340	COG3953	SLT domain
HC660_13340	COG5412	phage tail tape measure protein
HC660_13340	COG5412	phage tail tape measure protein
HC660_13340	COG3953	SLT domain
HC660_13340	COG5412	phage tail tape measure protein
HC660_13340	COG3953	SLT domain
HC660_13350	COG1652	LysM domain
HC660_13360	COG4193	domain, Protein
HC660_13380	COG3628	GPW Gp25 family protein
HC660_13390	COG3299	homolog of phage Mu protein gp47
HC660_13400	COG3778	Protein conserved in bacteria
HC660_13480	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC660_13480	COG3409	Peptidoglycan-binding domain 1 protein
HC660_13510	COG0306	phosphate transporter
HC660_13520	COG1392	Phosphate transport regulator
HC660_13530	COG0531	amino acid
HC660_13540	COG0346	lactoylglutathione lyase activity
HC660_13550	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC660_13560	COG0463	Glycosyl transferase, family 2
HC660_13570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC660_13580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC660_13590	COG2362	D-Aminopeptidase
HC660_13600	COG0601	transmembrane transport
HC660_13610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC660_13620	COG0444	Belongs to the ABC transporter superfamily
HC660_13630	COG4166	transmembrane transport
HC660_13640	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC660_13650	COG4948	Mandelate Racemase Muconate Lactonizing
HC660_13660	COG0791	NLP P60 protein
HC660_13670	COG4608	Belongs to the ABC transporter superfamily
HC660_13680	COG2706	6-phosphogluconolactonase activity
HC660_13690	COG1834	amidinotransferase
HC660_13700	COG1607	acyl-coa hydrolase
HC660_13710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC660_13710	COG1017	nitric oxide dioxygenase activity
HC660_13730	COG2323	membrane
HC660_13740	COG2318	DinB family
HC660_13750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC660_13760	COG2076	Multidrug Resistance protein
HC660_13770	COG2076	Multidrug Resistance protein
HC660_13780	COG0788	formyltetrahydrofolate deformylase activity
HC660_13790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC660_13800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HC660_13810	COG1764	response to oxidative stress
HC660_13820	COG1846	Transcriptional regulator
HC660_13830	COG1764	response to oxidative stress
HC660_13840	COG0463	Glycosyl transferase, family 2
HC660_13840	COG0457	Tetratricopeptide repeat
HC660_13850	COG0590	tRNA wobble adenosine to inosine editing
HC660_13860	COG0406	alpha-ribazole phosphatase activity
HC660_13870	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC660_13880	COG1404	Belongs to the peptidase S8 family
HC660_13890	COG1366	Belongs to the anti-sigma-factor antagonist family
HC660_13900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC660_13910	COG1122	ATPase activity
HC660_13920	COG4721	ABC-type cobalt transport system, permease component
HC660_13940	COG0745	RESPONSE REGULATOR receiver
HC660_13950	COG3850	Histidine kinase
HC660_13950	COG5002	protein histidine kinase activity
HC660_13960	COG3212	peptidase
HC660_13970	COG3212	peptidase
HC660_13980	COG2239	Acts as a magnesium transporter
HC660_13990	COG0789	Transcriptional regulator
HC660_14020	COG1846	Transcriptional regulator
HC660_14030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC660_14040	COG0726	polysaccharide deacetylase
HC660_14050	COG1408	metallophosphoesterase
HC660_14070	COG0463	Glycosyl transferase, family 2
HC660_14080	COG1793	dna ligase
HC660_14080	COG3285	dna ligase
HC660_14090	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HC660_14100	COG3300	MHYT domain
HC660_14100	COG5001	Diguanylate cyclase
HC660_14110	COG0586	Pfam SNARE associated Golgi protein
HC660_14120	COG0861	Integral membrane protein TerC family
HC660_14130	COG1191	sigma factor activity
HC660_14170	COG0501	Belongs to the peptidase M48B family
HC660_14180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC660_14210	COG3594	Acyltransferase
HC660_14220	COG5002	protein histidine kinase activity
HC660_14230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC660_14240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HC660_14250	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HC660_14260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC660_14270	COG0436	Aminotransferase
HC660_14280	COG1850	ribulose-bisphosphate carboxylase activity
HC660_14290	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HC660_14300	COG0235	Class ii aldolase
HC660_14310	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HC660_14320	COG3339	Conserved Protein
HC660_14350	COG3852	Histidine kinase
HC660_14360	COG1846	Transcriptional regulator
HC660_14370	COG1360	Flagellar Motor Protein
HC660_14380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC660_14390	COG0542	response to heat
HC660_14400	COG3949	Membrane
HC660_14410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HC660_14420	COG0720	synthase
HC660_14430	COG0602	queuosine metabolic process
HC660_14440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HC660_14460	COG4873	Protein conserved in bacteria
HC660_14480	COG3773	Cell wall hydrolase
HC660_14490	COG2244	polysaccharide biosynthetic process
HC660_14500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC660_14510	COG2217	Heavy metal translocating P-type atpase
HC660_14520	COG0006	proline dipeptidase activity
HC660_14530	COG1609	Transcriptional regulator
HC660_14540	COG3711	transcriptional antiterminator
HC660_14550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC660_14550	COG2190	(PTS) system
HC660_14550	COG1263	PTS System
HC660_14560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC660_14570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC660_14590	COG1533	DNA photolyase activity
HC660_14600	COG0456	acetyltransferase
HC660_14610	COG0840	transmembrane signaling receptor activity
HC660_14620	COG2084	Dehydrogenase
HC660_14630	COG2340	Cysteine-rich secretory protein family
HC660_14640	COG0768	penicillin binding
HC660_14650	COG4191	Histidine kinase
HC660_14660	COG0436	Aminotransferase
HC660_14680	COG0835	chemotaxis
HC660_14680	COG0784	Response regulator, receiver
HC660_14700	COG2814	Major facilitator Superfamily
HC660_14710	COG1376	ErfK ybiS ycfS ynhG family protein
HC660_14720	COG1408	metallophosphoesterase
HC660_14730	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_14740	COG2200	EAL domain
HC660_14760	COG4703	Protein of unknown function (DUF1797)
HC660_14770	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HC660_14790	COG0517	IMP dehydrogenase activity
HC660_14800	COG0583	DNA-binding transcription factor activity
HC660_14810	COG0716	FMN binding
HC660_14830	COG0716	FMN binding
HC660_14840	COG2171	N-acyltransferase activity
HC660_14850	COG1473	amidohydrolase
HC660_14870	COG0668	transmembrane transport
HC660_14880	COG0450	alkyl hydroperoxide reductase
HC660_14890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC660_14920	COG0746	molybdenum cofactor guanylyltransferase activity
HC660_14930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC660_14940	COG0303	'Molybdopterin
HC660_14950	COG1763	Mo-molybdopterin cofactor biosynthetic process
HC660_14960	COG0314	molybdopterin synthase activity
HC660_14970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HC660_14980	COG1132	(ABC) transporter
HC660_14990	COG1132	(ABC) transporter
HC660_15010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC660_15020	COG1136	(ABC) transporter
HC660_15030	COG0577	efflux transmembrane transporter activity
HC660_15040	COG1349	DNA-binding transcription factor activity
HC660_15050	COG1105	Belongs to the carbohydrate kinase PfkB family
HC660_15060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC660_15060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC660_15060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC660_15070	COG0681	Belongs to the peptidase S26 family
HC660_15090	COG0488	(ABC) transporter
HC660_15100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC660_15110	COG2309	aminopeptidase activity
HC660_15120	COG1077	Cell shape determining protein MreB Mrl
HC660_15130	COG2002	toxin-antitoxin pair type II binding
HC660_15140	COG3852	Histidine kinase
HC660_15150	COG2105	PFAM AIG2 family protein
HC660_15150	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HC660_15160	COG0569	domain protein
HC660_15170	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC660_15180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC660_15200	COG0561	phosphatase activity
HC660_15210	COG0242	peptide deformylase activity
HC660_15220	COG0497	DNA recombination
HC660_15230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC660_15240	COG0022	dehydrogenase e1 component
HC660_15250	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC660_15260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC660_15270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC660_15280	COG1982	Orn Lys Arg decarboxylase major
HC660_15290	COG4476	Belongs to the UPF0223 family
HC660_15300	COG4493	Belongs to the UPF0637 family
HC660_15320	COG0483	inositol monophosphate 1-phosphatase activity
HC660_15340	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HC660_15380	COG1595	DNA-templated transcription, initiation
HC660_15440	COG4896	Protein conserved in bacteria
HC660_15460	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HC660_15470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC660_15480	COG2066	Belongs to the glutaminase family
HC660_15490	COG4838	Belongs to the UPF0358 family
HC660_15500	COG0772	Belongs to the SEDS family
HC660_15510	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HC660_15520	COG1612	heme a metabolic process
HC660_15530	COG0109	protoheme IX farnesyltransferase activity
HC660_15540	COG2010	Cytochrome c
HC660_15540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC660_15550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC660_15560	COG1845	cytochrome c oxidase, subunit III
HC660_15570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC660_15580	COG3336	cytochrome c oxidase
HC660_15600	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HC660_15610	COG2340	Cysteine-rich secretory protein family
HC660_15640	COG3679	Belongs to the UPF0342 family
HC660_15650	COG4471	UPF0298 protein
HC660_15660	COG0742	ribosomal rna small subunit methyltransferase
HC660_15670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HC660_15680	COG3314	Sporulation integral membrane protein YlbJ
HC660_15690	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC660_15700	COG3480	Lon protease (S16) C-terminal proteolytic domain
HC660_15710	COG1323	Belongs to the UPF0348 family
HC660_15720	COG1399	metal-binding, possibly nucleic acid-binding protein
HC660_15750	COG0454	-acetyltransferase
HC660_15760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC660_15770	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HC660_15780	COG2001	Belongs to the MraZ family
HC660_15790	COG0275	rRNA processing
HC660_15800	COG4839	cell division protein FtsL
HC660_15820	COG0768	penicillin binding
HC660_15830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC660_15840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC660_15850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC660_15860	COG0772	Belongs to the SEDS family
HC660_15870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC660_15880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HC660_15890	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HC660_15900	COG3879	Bacterial protein of unknown function (DUF881)
HC660_15910	COG3879	Bacterial protein of unknown function (DUF881)
HC660_15920	COG3856	small basic protein
HC660_15930	COG0849	cell division
HC660_15940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC660_15950	COG1404	Belongs to the peptidase S8 family
HC660_15950	COG4412	M6 family metalloprotease domain protein
HC660_15970	COG1191	sigma factor activity
HC660_15980	COG1191	sigma factor activity
HC660_15990	COG1119	ATPase activity
HC660_16000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC660_16010	COG1873	PFAM PRC-barrel domain
HC660_16030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC660_16040	COG1799	cell septum assembly
HC660_16050	COG0762	integral membrane protein
HC660_16060	COG2302	S4 RNA-binding domain
HC660_16070	COG3599	regulation of cell shape
HC660_16080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HC660_16090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC660_16100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HC660_16110	COG0564	pseudouridine synthase activity
HC660_16120	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HC660_16130	COG2233	PERMEase
HC660_16140	COG0540	Belongs to the ATCase OTCase family
HC660_16150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC660_16160	COG0505	Belongs to the CarA family
HC660_16170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC660_16180	COG0543	2 iron, 2 sulfur cluster binding
HC660_16190	COG0167	dihydroorotate dehydrogenase activity
HC660_16200	COG0284	orotidine-5'-phosphate decarboxylase activity
HC660_16210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HC660_16220	COG0175	sulfate reduction
HC660_16230	COG0306	phosphate transporter
HC660_16240	COG2046	Belongs to the sulfate adenylyltransferase family
HC660_16250	COG0529	Catalyzes the synthesis of activated sulfate
HC660_16260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC660_16270	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HC660_16280	COG1648	precorrin-2 dehydrogenase activity
HC660_16290	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HC660_16300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC660_16310	COG1561	YicC-like family, N-terminal region
HC660_16330	COG0194	GDP metabolic process
HC660_16340	COG1758	RNA polymerase activity
HC660_16350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC660_16360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC660_16370	COG0242	peptide deformylase activity
HC660_16380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HC660_16390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HC660_16390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC660_16400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HC660_16410	COG0631	protein serine/threonine phosphatase activity
HC660_16420	COG2815	serine threonine protein kinase
HC660_16420	COG0515	serine threonine protein kinase
HC660_16430	COG1162	GTPase activity
HC660_16440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC660_16450	COG1564	THIamine pyrophosphokinase
HC660_16460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC660_16470	COG1302	Protein conserved in bacteria
HC660_16480	COG1461	Dihydroxyacetone kinase
HC660_16490	COG1760	l-serine dehydratase
HC660_16500	COG1760	l-serine dehydratase
HC660_16510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC660_16520	COG2050	protein possibly involved in aromatic compounds catabolism
HC660_16520	COG1349	DNA-binding transcription factor activity
HC660_16530	COG0416	fatty acid biosynthetic process
HC660_16540	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC660_16550	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_16570	COG0571	ribonuclease III activity
HC660_16580	COG1196	nuclear chromosome segregation
HC660_16590	COG0552	protein localization to endoplasmic reticulum
HC660_16610	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HC660_16620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC660_16630	COG0228	four-way junction DNA binding
HC660_16640	COG1837	Belongs to the UPF0109 family
HC660_16660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HC660_16670	COG0336	Belongs to the RNA methyltransferase TrmD family
HC660_16680	COG0335	large ribosomal subunit rRNA binding
HC660_16690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC660_16700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC660_16720	COG2257	FlhB HrpN YscU SpaS Family
HC660_16730	COG0045	succinate-CoA ligase (ADP-forming) activity
HC660_16740	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HC660_16750	COG0758	DNA mediated transformation
HC660_16760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC660_16770	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HC660_16780	COG4974	Belongs to the 'phage' integrase family
HC660_16790	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HC660_16800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HC660_16810	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC660_16820	COG1815	bacterial-type flagellum-dependent cell motility
HC660_16830	COG1558	bacterial-type flagellum-dependent cell motility
HC660_16840	COG1677	Flagellar hook-basal body complex protein FliE
HC660_16850	COG1766	The M ring may be actively involved in energy transduction
HC660_16860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC660_16870	COG1317	bacterial-type flagellum organization
HC660_16880	COG1157	protein secretion by the type III secretion system
HC660_16890	COG2882	bacterial-type flagellum organization
HC660_16900	COG3334	PFAM MgtE intracellular
HC660_16910	COG3144	bacterial-type flagellum assembly
HC660_16920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HC660_16930	COG4786	Flagellar basal body rod
HC660_16940	COG1582	Flagellar protein (FlbD)
HC660_16950	COG1580	Controls the rotational direction of flagella during chemotaxis
HC660_16960	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC660_16970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC660_16970	COG1776	CheC inhibitor of MCP methylation
HC660_16980	COG2201	protein-glutamate methylesterase activity
HC660_16990	COG3190	flagellar
HC660_17000	COG1338	Plays a role in the flagellum-specific transport system
HC660_17010	COG1987	bacterial-type flagellum assembly
HC660_17020	COG1684	flagellar biosynthetic protein fliR
HC660_17030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC660_17040	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC660_17050	COG1419	protein localization to endoplasmic reticulum
HC660_17060	COG0455	bacterial-type flagellum organization
HC660_17070	COG2201	protein-glutamate methylesterase activity
HC660_17080	COG0643	Histidine kinase
HC660_17080	COG2198	Histidine kinase
HC660_17090	COG0835	chemotaxis
HC660_17100	COG1776	CheC inhibitor of MCP methylation
HC660_17110	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HC660_17120	COG1191	sigma factor activity
HC660_17140	COG0052	Belongs to the universal ribosomal protein uS2 family
HC660_17150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HC660_17160	COG0528	UMP kinase activity
HC660_17170	COG0233	cytoplasmic translational termination
HC660_17180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC660_17190	COG4589	Belongs to the CDS family
HC660_17200	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HC660_17210	COG0750	zinc metalloprotease
HC660_17220	COG0442	prolyl-tRNA aminoacylation
HC660_17230	COG2176	DNA-directed DNA polymerase activity
HC660_17240	COG0779	Required for maturation of 30S ribosomal subunits
HC660_17250	COG0195	Participates in both transcription termination and antitermination
HC660_17260	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HC660_17270	COG1358	cellular component organization or biogenesis
HC660_17280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HC660_17290	COG1550	Protein conserved in bacteria
HC660_17300	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HC660_17310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HC660_17320	COG0196	riboflavin kinase activity
HC660_17340	COG1185	polyribonucleotide nucleotidyltransferase activity
HC660_17350	COG0726	polysaccharide deacetylase
HC660_17360	COG0612	Peptidase, M16
HC660_17370	COG1873	PFAM PRC-barrel domain
HC660_17380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC660_17390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC660_17400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC660_17410	COG0527	aspartate kinase activity
HC660_17420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC660_17430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC660_17440	COG0740	serine-type endopeptidase activity
HC660_17460	COG1674	ftsk spoiiie
HC660_17460	COG4980	gas vesicle protein
HC660_17470	COG2188	Transcriptional regulator
HC660_17480	COG2814	Major facilitator Superfamily
HC660_17490	COG0612	Peptidase, M16
HC660_17500	COG0612	Peptidase, M16
HC660_17510	COG0300	oxidoreductase activity
HC660_17540	COG1426	Protein conserved in bacteria
HC660_17550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC660_17560	COG1058	Belongs to the CinA family
HC660_17560	COG1546	Belongs to the CinA family
HC660_17570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HC660_17580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC660_17590	COG1418	mRNA catabolic process
HC660_17600	COG1692	metallophosphoesterase
HC660_17610	COG2359	stage V sporulation protein S
HC660_17620	COG1063	alcohol dehydrogenase
HC660_17630	COG0156	8-amino-7-oxononanoate synthase activity
HC660_17640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC660_17650	COG4550	Control of competence regulator ComK, YlbF/YmcA
HC660_17670	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HC660_17680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HC660_17700	COG0582	viral genome integration into host DNA
HC660_17760	COG4824	toxin secretion phage lysis holin
HC660_17790	COG5444	nuclease activity
HC660_17830	COG3226	Transcriptional regulator
HC660_17850	COG1404	Belongs to the peptidase S8 family
HC660_17860	COG4195	phage-related replication protein
HC660_17870	COG1764	response to oxidative stress
HC660_17920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HC660_17930	COG1923	regulation of RNA biosynthetic process
HC660_17970	COG1780	Probably involved in ribonucleotide reductase function
HC660_17980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC660_17990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC660_18000	COG4112	unkown
HC660_18010	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC660_18020	COG0464	growth
HC660_18030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC660_18040	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HC660_18050	COG0789	Transcriptional regulator
HC660_18060	COG0174	glutamine synthetase
HC660_18090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC660_18120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC660_18130	COG3403	YqcI/YcgG family
HC660_18140	COG2273	Hydrolase Family 16
HC660_18160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC660_18170	COG2720	vancomycin resistance protein
HC660_18180	COG3739	integral membrane protein
HC660_18190	COG3655	Transcriptional regulator
HC660_18210	COG2135	peptidase activity
HC660_18240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC660_18320	COG4195	phage-related replication protein
HC660_18360	COG0346	lactoylglutathione lyase activity
HC660_18380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC660_18390	COG1388	LysM domain
HC660_18400	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC660_18410	COG4224	UPF0291 protein
HC660_18420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC660_18440	COG3763	UPF0154 protein
HC660_18460	COG0785	Cytochrome C biogenesis protein
HC660_18470	COG2201	protein-glutamate methylesterase activity
HC660_18480	COG4846	Membrane protein involved in cytochrome C biogenesis
HC660_18500	COG0071	Belongs to the small heat shock protein (HSP20) family
HC660_18530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC660_18540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC660_18570	COG0824	Thioesterase
HC660_18590	COG4841	protein insertion into membrane
HC660_18600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HC660_18610	COG1832	CoA-binding protein
HC660_18620	COG0187	DNA topoisomerase II activity
HC660_18630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC660_18650	COG1115	amino acid carrier protein
HC660_18660	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HC660_18690	COG0745	RESPONSE REGULATOR receiver
HC660_18710	COG3507	Belongs to the glycosyl hydrolase 43 family
HC660_18720	COG2246	polysaccharide biosynthetic process
HC660_18730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC660_18740	COG0586	Pfam SNARE associated Golgi protein
HC660_18750	COG2404	hydrolase activity, acting on ester bonds
HC660_18760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC660_18770	COG1024	Enoyl-CoA hydratase
HC660_18780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC660_18790	COG0511	ligase activity, forming carbon-carbon bonds
HC660_18800	COG0439	Biotin carboxylase
HC660_18810	COG0318	PFAM AMP-dependent synthetase and ligase
HC660_18820	COG1960	acyl-CoA dehydrogenase activity
HC660_18850	COG1649	PFAM Uncharacterised BCR, COG1649
HC660_18870	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC660_18870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC660_18880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC660_18890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC660_18900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC660_18910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC660_18920	COG2027	D-alanyl-D-alanine carboxypeptidase
HC660_18930	COG2017	converts alpha-aldose to the beta-anomer
HC660_18940	COG0534	Mate efflux family protein
HC660_18970	COG0582	viral genome integration into host DNA
HC660_18980	COG0166	Belongs to the GPI family
HC660_18990	COG0405	Gamma-glutamyltransferase
HC660_19000	COG0583	DNA-binding transcription factor activity
HC660_19010	COG0604	alcohol dehydrogenase
HC660_19020	COG0493	'glutamate synthase
HC660_19030	COG0069	glutamate synthase activity
HC660_19030	COG0070	glutamate synthase
HC660_19030	COG0067	glutamate synthase
HC660_19040	COG0583	DNA-binding transcription factor activity
HC660_19050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC660_19090	COG0300	oxidoreductase activity
HC660_19100	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC660_19120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC660_19150	COG1131	(ABC) transporter
HC660_19170	COG2814	Major facilitator Superfamily
HC660_19180	COG1070	Carbohydrate kinase
HC660_19190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC660_19200	COG0243	molybdopterin cofactor binding
HC660_19220	COG4305	rare lipoprotein A
HC660_19230	COG3619	membrane
HC660_19250	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_19310	COG2814	Major facilitator Superfamily
HC660_19320	COG1525	nuclease
HC660_19330	COG1231	oxidoreductase activity
HC660_19350	COG1070	Carbohydrate kinase
HC660_19380	COG3507	Belongs to the glycosyl hydrolase 43 family
HC660_19390	COG2211	Major facilitator Superfamily
HC660_19430	COG3397	chitin binding
HC660_19440	COG2318	DinB family
HC660_19450	COG0726	polysaccharide deacetylase
HC660_19470	COG1388	LysM domain
HC660_19550	COG3655	Transcriptional regulator
HC660_19560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC660_19570	COG0457	Tetratricopeptide repeat
HC660_19590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC660_19600	COG0574	Belongs to the PEP-utilizing enzyme family
HC660_19600	COG3848	Pyruvate phosphate dikinase
HC660_19640	COG5444	nuclease activity
HC660_19650	COG4282	regulation of fungal-type cell wall biogenesis
HC660_19690	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_19700	COG1733	regulation of RNA biosynthetic process
HC660_19710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC660_19720	COG0662	Cupin 2, conserved barrel domain protein
HC660_19720	COG2207	Transcriptional regulator
HC660_19730	COG0456	acetyltransferase
HC660_19740	COG1309	transcriptional regulator
HC660_19750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC660_19760	COG3708	Transcriptional regulator
HC660_19770	COG2378	regulation of single-species biofilm formation
HC660_19790	COG0640	Transcriptional regulator
HC660_19800	COG0741	lytic transglycosylase activity
HC660_19810	COG2322	membrane
HC660_19840	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC660_19850	COG3239	Fatty acid desaturase
HC660_19860	COG4585	Histidine kinase
HC660_19870	COG2197	response regulator
HC660_19880	COG3584	3D domain protein
HC660_19880	COG1388	LysM domain
HC660_19890	COG0514	ATP-dependent DNA helicase (RecQ)
HC660_19900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC660_19910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC660_19940	COG1012	belongs to the aldehyde dehydrogenase family
HC660_19950	COG1657	PFAM Prenyltransferase squalene oxidase
HC660_19960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC660_19970	COG0733	neurotransmitter:sodium symporter activity
HC660_19980	COG0385	Bile acid
HC660_19990	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC660_20000	COG0567	Dehydrogenase, E1 component
HC660_20010	COG4548	von Willebrand factor, type A
HC660_20020	COG0714	Associated with various cellular activities
HC660_20030	COG2032	superoxide dismutase activity
HC660_20040	COG1388	LysM domain
HC660_20040	COG0791	NLP P60 protein
HC660_20050	COG1819	glycosyl
HC660_20060	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC660_20070	COG0534	Mate efflux family protein
HC660_20080	COG1366	Belongs to the anti-sigma-factor antagonist family
HC660_20090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC660_20100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC660_20120	COG2962	Rard protein
HC660_20150	COG2610	gluconate transmembrane transporter activity
HC660_20150	COG2610	gluconate transmembrane transporter activity
HC660_20160	COG1942	4-Oxalocrotonate Tautomerase
HC660_20180	COG1733	regulation of RNA biosynthetic process
HC660_20190	COG0778	Nitroreductase
HC660_20200	COG0400	carboxylic ester hydrolase activity
HC660_20210	COG0346	lactoylglutathione lyase activity
HC660_20230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC660_20240	COG3409	Peptidoglycan-binding domain 1 protein
HC660_20240	COG0793	Belongs to the peptidase S41A family
HC660_20250	COG2226	methyltransferase
HC660_20270	COG1876	peptidase activity
HC660_20280	COG0813	purine-nucleoside phosphorylase activity
HC660_20300	COG0671	phosphoesterase, PA-phosphatase related
HC660_20330	COG4479	Belongs to the UPF0346 family
HC660_20350	COG1509	lysine 2,3-aminomutase activity
HC660_20360	COG0456	acetyltransferase
HC660_20370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC660_20380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC660_20390	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC660_20400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC660_20410	COG0456	acetyltransferase
HC660_20420	COG0463	Glycosyl transferase, family 2
HC660_20450	COG4641	Protein conserved in bacteria
HC660_20460	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HC660_20480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC660_20490	COG1846	Transcriptional regulator
HC660_20500	COG0534	Mate efflux family protein
HC660_20520	COG4698	Protein conserved in bacteria
HC660_20530	COG2755	lipolytic protein G-D-S-L family
HC660_20540	COG1999	signal sequence binding
HC660_20560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC660_20570	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC660_20580	COG1272	protein, Hemolysin III
HC660_20590	COG0204	Acyl-transferase
HC660_20600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC660_20620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC660_20640	COG2136	Putative SAM-dependent methyltransferase
HC660_20640	COG2521	methyltransferase
HC660_20660	COG0129	dihydroxy-acid dehydratase activity
HC660_20670	COG1413	lyase activity
HC660_20680	COG1418	mRNA catabolic process
HC660_20690	COG0386	Belongs to the glutathione peroxidase family
HC660_20700	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HC660_20710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC660_20720	COG1278	Cold shock
HC660_20760	COG0328	RNA-DNA hybrid ribonuclease activity
HC660_20770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HC660_20780	COG0328	RNA-DNA hybrid ribonuclease activity
HC660_20800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC660_20820	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC660_20830	COG1755	Isoprenylcysteine carboxyl methyltransferase
HC660_20840	COG3424	synthase
HC660_20850	COG2233	PERMEase
HC660_20860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC660_20870	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HC660_20890	COG0800	Aldolase
HC660_20900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC660_20910	COG1609	Transcriptional regulator
HC660_20920	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HC660_20930	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_20940	COG1199	ATP-dependent helicase activity
HC660_20970	COG0116	Belongs to the methyltransferase superfamily
HC660_20990	COG4474	Belongs to the UPF0398 family
HC660_21010	COG3359	exonuclease
HC660_21020	COG1111	helicase
HC660_21020	COG1205	dead DEAH box helicase
HC660_21030	COG2190	(PTS) system
HC660_21040	COG0071	Belongs to the small heat shock protein (HSP20) family
HC660_21110	COG3331	DNA recombination
HC660_21120	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC660_21120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC660_21140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HC660_21150	COG3935	DnaD domain protein
HC660_21160	COG0017	Asparaginyl-tRNA synthetase
HC660_21170	COG0436	Aminotransferase
HC660_21180	COG5353	protein conserved in bacteria
HC660_21200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC660_21200	COG1199	ATP-dependent helicase activity
HC660_21210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HC660_21220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HC660_21230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HC660_21240	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HC660_21240	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HC660_21250	COG0617	tRNA 3'-terminal CCA addition
HC660_21260	COG0438	transferase activity, transferring glycosyl groups
HC660_21270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC660_21280	COG1803	Methylglyoxal synthase
HC660_21290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HC660_21300	COG1694	Mazg nucleotide pyrophosphohydrolase
HC660_21310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC660_21330	COG4347	Protein of unknown function (DUF1405)
HC660_21340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC660_21340	COG2010	Cytochrome c
HC660_21350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC660_21360	COG0723	plastoquinol--plastocyanin reductase activity
HC660_21380	COG5582	Belongs to the UPF0302 family
HC660_21390	COG0457	Tetratricopeptide repeat
HC660_21400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HC660_21410	COG0287	Prephenate dehydrogenase
HC660_21420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC660_21430	COG0159	tryptophan synthase activity
HC660_21440	COG0133	tryptophan synthase activity
HC660_21450	COG0135	phosphoribosylanthranilate isomerase activity
HC660_21470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC660_21480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC660_21490	COG4401	Chorismate mutase type I
HC660_21500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HC660_21510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HC660_21520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HC660_21530	COG0105	UTP biosynthetic process
HC660_21540	COG0142	geranyltranstransferase activity
HC660_21550	COG2226	methyltransferase
HC660_21560	COG0142	geranyltranstransferase activity
HC660_21580	COG0302	gtp cyclohydrolase
HC660_21590	COG0776	regulation of translation
HC660_21600	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC660_21630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HC660_21640	COG1160	GTP binding
HC660_21680	COG1304	FMN binding
HC660_21690	COG0539	negative regulation of cytoplasmic translation
HC660_21700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HC660_21720	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HC660_21730	COG2959	enzyme of heme biosynthesis
HC660_21740	COG3773	Cell wall hydrolase
HC660_21740	COG3409	Peptidoglycan-binding domain 1 protein
HC660_21750	COG2339	peptidase activity
HC660_21760	COG0492	ferredoxin-NADP+ reductase activity
HC660_21770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC660_21780	COG4862	establishment of competence for transformation
HC660_21790	COG1408	metallophosphoesterase
HC660_21810	COG1388	LysM domain
HC660_21820	COG1266	CAAX protease self-immunity
HC660_21830	COG0514	ATP-dependent DNA helicase (RecQ)
HC660_21840	COG4955	Helix-turn-helix domain
HC660_21850	COG1141	Ferredoxin
HC660_21860	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HC660_21870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC660_21880	COG0710	3-dehydroquinate dehydratase activity
HC660_21900	COG1595	DNA-templated transcription, initiation
HC660_21910	COG5002	protein histidine kinase activity
HC660_21920	COG0745	RESPONSE REGULATOR receiver
HC660_21930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC660_21940	COG1333	cytochrome c biogenesis protein
HC660_21950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC660_21960	COG1187	pseudouridine synthase activity
HC660_21970	COG0700	Nucleoside recognition
HC660_21980	COG2715	membrane protein required for spore maturation
HC660_21990	COG1686	Belongs to the peptidase S11 family
HC660_22010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HC660_22020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HC660_22030	COG1547	Domain of unknown function (DUF309)
HC660_22040	COG0456	acetyltransferase
HC660_22050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HC660_22060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC660_22060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC660_22070	COG0307	riboflavin synthase, alpha
HC660_22080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC660_22080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC660_22100	COG0681	Belongs to the peptidase S26 family
HC660_22110	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HC660_22120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HC660_22130	COG4086	secreted protein
HC660_22140	COG0019	diaminopimelate decarboxylase activity
HC660_22150	COG0697	spore germination
HC660_22180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC660_22220	COG1191	sigma factor activity
HC660_22230	COG2172	sigma factor antagonist activity
HC660_22240	COG1366	Belongs to the anti-sigma-factor antagonist family
HC660_22250	COG1686	Belongs to the peptidase S11 family
HC660_22260	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HC660_22270	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HC660_22280	COG4974	Belongs to the 'phage' integrase family
HC660_22300	COG0735	belongs to the Fur family
HC660_22310	COG1300	Membrane
HC660_22330	COG0281	malic enzyme
HC660_22340	COG1757	Na H antiporter
HC660_22350	COG1027	Aspartate ammonia-lyase
HC660_22360	COG0252	asparaginase activity
HC660_22370	COG1396	sequence-specific DNA binding
HC660_22380	COG1379	DNA repair
HC660_22390	COG0494	nUDIX hydrolase
HC660_22400	COG0667	Aldo Keto reductase
HC660_22420	COG1073	alpha beta
HC660_22440	COG4918	Iron-sulphur cluster biosynthesis
HC660_22450	COG0456	acetyltransferase
HC660_22450	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HC660_22460	COG2329	Antibiotic biosynthesis monooxygenase
HC660_22470	COG0456	acetyltransferase
HC660_22490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC660_22510	COG2211	Major facilitator Superfamily
HC660_22530	COG0346	lactoylglutathione lyase activity
HC660_22540	COG1072	(Pantothenic acid kinase))
HC660_22550	COG3048	D-serine ammonia-lyase activity
HC660_22560	COG0300	oxidoreductase activity
HC660_22570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC660_22580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC660_22590	COG4187	Peptidase family M20/M25/M40
HC660_22600	COG1902	pentaerythritol trinitrate reductase activity
HC660_22610	COG0596	Alpha beta hydrolase
HC660_22630	COG1234	tRNA 3'-trailer cleavage
HC660_22640	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HC660_22660	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC660_22670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC660_22690	COG0706	membrane insertase activity
HC660_22700	COG3361	conserved protein (COG2071)
HC660_22710	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC660_22720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC660_22730	COG0346	lactoylglutathione lyase activity
HC660_22740	COG1376	ErfK ybiS ycfS ynhG family protein
HC660_22750	COG4129	membrane
HC660_22760	COG1126	abc transporter atp-binding protein
HC660_22770	COG0765	amino acid transport
HC660_22780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC660_22800	COG1597	lipid kinase activity
HC660_22810	COG2814	Major facilitator Superfamily
HC660_22820	COG4978	Transcriptional regulator
HC660_22820	COG0789	Transcriptional regulator
HC660_22830	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC660_22840	COG0022	dehydrogenase e1 component
HC660_22850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC660_22860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC660_22870	COG3426	butyrate kinase activity
HC660_22880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC660_22890	COG0280	phosphate acetyltransferase
HC660_22900	COG3829	transcription factor binding
HC660_22900	COG3290	protein histidine kinase activity
HC660_22920	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HC660_22930	COG2079	MmgE PrpD family protein
HC660_22940	COG0372	Belongs to the citrate synthase family
HC660_22950	COG1960	acyl-CoA dehydrogenase activity
HC660_22960	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC660_22970	COG0183	Belongs to the thiolase family
HC660_22980	COG0584	glycerophosphoryl diester phosphodiesterase
HC660_22990	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC660_23010	COG1902	pentaerythritol trinitrate reductase activity
HC660_23020	COG0745	RESPONSE REGULATOR receiver
HC660_23030	COG0750	zinc metalloprotease
HC660_23040	COG0497	DNA recombination
HC660_23050	COG1438	arginine binding
HC660_23060	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HC660_23070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HC660_23080	COG0142	geranyltranstransferase activity
HC660_23090	COG1722	exodeoxyribonuclease VII activity
HC660_23100	COG1570	exodeoxyribonuclease VII activity
HC660_23110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HC660_23120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC660_23130	COG1302	Protein conserved in bacteria
HC660_23140	COG0439	Biotin carboxylase
HC660_23150	COG0511	ligase activity, forming carbon-carbon bonds
HC660_23230	COG3854	ATPases associated with a variety of cellular activities
HC660_23250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HC660_23260	COG0006	proline dipeptidase activity
HC660_23270	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HC660_23290	COG3872	metal-dependent enzyme
HC660_23310	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC660_23320	COG1321	iron dependent repressor
HC660_23330	COG0095	Lipoate-protein ligase
HC660_23340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC660_23350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC660_23360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC660_23370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC660_23380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC660_23410	COG1396	sequence-specific DNA binding
HC660_23430	COG0681	Belongs to the peptidase S26 family
HC660_23480	COG4940	Competence protein ComGF
HC660_23500	COG4970	Tfp pilus assembly protein FimT
HC660_23510	COG4537	Required for transformation and DNA binding
HC660_23520	COG1459	type II secretion system
HC660_23530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HC660_23540	COG0517	IMP dehydrogenase activity
HC660_23550	COG0598	Magnesium transport protein CorA
HC660_23560	COG1253	flavin adenine dinucleotide binding
HC660_23570	COG1366	Belongs to the anti-sigma-factor antagonist family
HC660_23590	COG1393	Belongs to the ArsC family
HC660_23610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC660_23630	COG0011	TIGRFAM Protein of
HC660_23650	COG2866	Carboxypeptidase
HC660_23660	COG1368	sulfuric ester hydrolase activity
HC660_23670	COG1940	carbohydrate kinase activity
HC660_23680	COG4483	Protein conserved in bacteria
HC660_23690	COG0457	Tetratricopeptide repeat
HC660_23690	COG0705	Rhomboid family
HC660_23710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC660_23730	COG0438	transferase activity, transferring glycosyl groups
HC660_23760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC660_23770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC660_23780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC660_23790	COG0581	inorganic phosphate transmembrane transporter activity
HC660_23800	COG0573	inorganic phosphate transmembrane transporter activity
HC660_23810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC660_23830	COG0477	Major facilitator Superfamily
HC660_23840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC660_23850	COG2839	Protein conserved in bacteria
HC660_23860	COG5521	maltodextrose utilization protein MalA
HC660_23870	COG1388	LysM domain
HC660_23880	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HC660_23890	COG4709	membrane
HC660_23900	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HC660_23910	COG0735	belongs to the Fur family
HC660_23920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC660_23940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HC660_23950	COG0513	Belongs to the DEAD box helicase family
HC660_23970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HC660_23980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HC660_23990	COG2384	SAM-dependent methyltransferase
HC660_24000	COG2010	Cytochrome c
HC660_24010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC660_24020	COG0358	DNA primase activity
HC660_24030	COG1671	Belongs to the UPF0178 family
HC660_24040	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HC660_24050	COG0517	IMP dehydrogenase activity
HC660_24060	COG0751	glycine-tRNA ligase activity
HC660_24070	COG0752	glycyl-tRNA synthetase alpha subunit
HC660_24080	COG1381	Involved in DNA repair and RecF pathway recombination
HC660_24090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC660_24100	COG0295	cytidine deaminase activity
HC660_24120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HC660_24130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HC660_24140	COG1480	7TM receptor with intracellular HD hydrolase
HC660_24150	COG1702	phosphate starvation-inducible protein PhoH
HC660_24160	COG0561	phosphatase activity
HC660_24190	COG4864	UPF0365 protein
HC660_24200	COG1030	water channel activity
HC660_24210	COG1610	YqeY-like protein
HC660_24230	COG1283	sodium-dependent phosphate transmembrane transporter activity
HC660_24240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC660_24250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC660_24260	COG2264	protein methyltransferase activity
HC660_24290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC660_24300	COG1420	regulation of RNA biosynthetic process
HC660_24310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC660_24320	COG0481	GTPase activity
HC660_24340	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC660_24350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HC660_24370	COG1466	dna polymerase III delta subunit
HC660_24380	COG0658	competence protein
HC660_24380	COG2333	competence protein COMEC
HC660_24390	COG2131	deaminase
HC660_24400	COG1555	photosystem II stabilization
HC660_24400	COG1596	polysaccharide export
HC660_24410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC660_24420	COG2226	methyltransferase
HC660_24430	COG0799	negative regulation of ribosome biogenesis
HC660_24440	COG1713	HD superfamily hydrolase involved in NAD metabolism
HC660_24450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HC660_24460	COG1534	Rna-binding protein
HC660_24470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC660_24480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC660_24490	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HC660_24500	COG2755	lipolytic protein G-D-S-L family
HC660_24510	COG3409	Peptidoglycan-binding domain 1 protein
HC660_24510	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC660_24520	COG0398	Pfam SNARE associated Golgi protein
HC660_24530	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HC660_24550	COG3209	COG3209 Rhs family protein
HC660_24570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC660_24580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC660_24610	COG0730	response to heat
HC660_24620	COG0425	Belongs to the sulfur carrier protein TusA family
HC660_24630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC660_24630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC660_24650	COG0425	Belongs to the sulfur carrier protein TusA family
HC660_24650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC660_24670	COG2210	Belongs to the sulfur carrier protein TusA family
HC660_24680	COG1937	Protein conserved in bacteria
HC660_24690	COG1522	sequence-specific DNA binding
HC660_24700	COG0457	Tetratricopeptide repeat
HC660_24710	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HC660_24730	COG2856	Zn peptidase
HC660_24740	COG0114	fumarate hydratase activity
HC660_24750	COG0583	DNA-binding transcription factor activity
HC660_24760	COG2070	2-Nitropropane dioxygenase
HC660_24770	COG1846	Transcriptional regulator
HC660_24820	COG2124	cytochrome p450
HC660_24840	COG1309	transcriptional regulator
HC660_24890	COG1725	Transcriptional regulator
HC660_24900	COG0747	negative chemotaxis
HC660_24910	COG0601	transmembrane transport
HC660_24920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC660_24930	COG0444	Belongs to the ABC transporter superfamily
HC660_24940	COG4608	Belongs to the ABC transporter superfamily
HC660_24960	COG3443	Belongs to the bacterial solute-binding protein 9 family
HC660_24970	COG4991	sh3 domain protein
HC660_24980	COG4991	sh3 domain protein
HC660_25000	COG1794	racemase activity, acting on amino acids and derivatives
HC660_25030	COG0789	Transcriptional regulator
HC660_25040	COG1064	alcohol dehydrogenase
HC660_25050	COG0693	protein deglycase activity
HC660_25060	COG1621	beta-fructofuranosidase activity
HC660_25070	COG3716	PTS system mannose fructose sorbose family IID component
HC660_25080	COG3715	PTS system
HC660_25090	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC660_25100	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC660_25110	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC660_25110	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HC660_25120	COG1113	amino acid transport
HC660_25130	COG1280	lysine exporter protein (LysE YggA)
HC660_25140	COG1378	Sugar-specific transcriptional regulator TrmB
HC660_25150	COG1595	DNA-templated transcription, initiation
HC660_25170	COG2755	lipolytic protein G-D-S-L family
HC660_25170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HC660_25190	COG2124	cytochrome p450
HC660_25190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC660_25200	COG1309	transcriptional regulator
HC660_25210	COG2226	methyltransferase
HC660_25230	COG2116	formate transmembrane transporter activity
HC660_25240	COG5609	conserved protein (DUF2294)
HC660_25250	COG3383	formate dehydrogenase (NAD+) activity
HC660_25260	COG2427	Protein of unknown function (DUF1641)
HC660_25280	COG0626	cystathionine gamma-synthase activity
HC660_25290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC660_25300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HC660_25310	COG2226	methyltransferase
HC660_25340	COG0768	penicillin binding
HC660_25350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC660_25360	COG0572	uridine kinase
HC660_25390	COG4122	O-methyltransferase activity
HC660_25400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC660_25410	COG3906	Belongs to the UPF0473 family
HC660_25420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HC660_25430	COG4472	Bacterial protein of unknown function (DUF965)
HC660_25440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC660_25450	COG0628	permease
HC660_25470	COG3881	PFAM PRC-barrel domain
HC660_25480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC660_25490	COG0457	Tetratricopeptide repeat
HC660_25500	COG0482	sulfurtransferase activity
HC660_25510	COG1104	cysteine desulfurase activity
HC660_25520	COG1959	2 iron, 2 sulfur cluster binding
HC660_25530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC660_25540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HC660_25560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HC660_25570	COG0124	histidyl-tRNA synthetase
HC660_25590	COG3103	Sh3 type 3 domain protein
HC660_25590	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC660_25590	COG4991	sh3 domain protein
HC660_25600	COG1490	D-aminoacyl-tRNA deacylase activity
HC660_25610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC660_25620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC660_25630	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HC660_25630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HC660_25640	COG5416	Lipopolysaccharide assembly protein A domain
HC660_25650	COG0490	domain, Protein
HC660_25660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC660_25660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC660_25680	COG2244	polysaccharide biosynthetic process
HC660_25690	COG2323	membrane
HC660_25710	COG1862	Preprotein translocase
HC660_25720	COG0343	queuine tRNA-ribosyltransferase activity
HC660_25730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HC660_25750	COG2255	four-way junction helicase activity
HC660_25760	COG0632	four-way junction helicase activity
HC660_25780	COG2814	Major facilitator Superfamily
HC660_25790	COG0673	inositol 2-dehydrogenase activity
HC660_25800	COG2112	serine threonine protein kinase
HC660_25820	COG1115	amino acid carrier protein
HC660_25830	COG0217	transcriptional regulatory protein
HC660_25850	COG1388	LysM domain
HC660_25860	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HC660_25870	COG0157	Belongs to the NadC ModD family
HC660_25880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HC660_25890	COG1104	cysteine desulfurase activity
HC660_25900	COG1827	regulation of RNA biosynthetic process
HC660_25910	COG0077	Prephenate dehydratase
HC660_25920	COG4492	Belongs to the UPF0735 family
HC660_25930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC660_25940	COG3290	protein histidine kinase activity
HC660_25950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HC660_25960	COG2868	ribosomal protein
HC660_25970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HC660_25980	COG1994	Peptidase M50
HC660_25990	COG0739	heme binding
HC660_26000	COG2894	cell division
HC660_26010	COG0850	regulation of cytokinetic process
HC660_26020	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HC660_26040	COG1077	Cell shape determining protein MreB Mrl
HC660_26050	COG2003	Belongs to the UPF0758 family
HC660_26060	COG0424	maF-like protein
HC660_26080	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HC660_26090	COG0285	dihydrofolate synthase activity
HC660_26100	COG0525	valine-tRNA ligase activity
HC660_26120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC660_26130	COG1388	LysM domain
HC660_26140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC660_26150	COG0113	porphobilinogen synthase activity
HC660_26160	COG1587	Uroporphyrinogen-III synthase
HC660_26170	COG0181	hydroxymethylbilane synthase activity
HC660_26180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC660_26190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HC660_26210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HC660_26220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HC660_26230	COG0470	DNA polymerase III
HC660_26230	COG1067	ATP-dependent peptidase activity
HC660_26240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HC660_26250	COG0544	peptidyl-prolyl cis-trans isomerase activity
HC660_26260	COG1477	protein flavinylation
HC660_26260	COG0457	Tetratricopeptide repeat
HC660_26270	COG0066	3-isopropylmalate dehydratase activity
HC660_26280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HC660_26290	COG0473	3-isopropylmalate dehydrogenase activity
HC660_26300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC660_26310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HC660_26320	COG0440	acetolactate synthase activity
HC660_26330	COG0028	Belongs to the TPP enzyme family
HC660_26350	COG0454	-acetyltransferase
HC660_26360	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HC660_26400	COG1674	ftsk spoiiie
HC660_26440	COG1388	LysM domain
HC660_26440	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC660_26440	COG3409	Peptidoglycan-binding domain 1 protein
HC660_26490	COG5412	phage tail tape measure protein
HC660_26490	COG3953	SLT domain
HC660_26570	COG0740	serine-type endopeptidase activity
HC660_26650	COG1216	Glycosyl transferase, family 2
HC660_26660	COG4195	phage-related replication protein
HC660_26670	COG3420	alginic acid biosynthetic process
HC660_26670	COG5434	Belongs to the glycosyl hydrolase 28 family
HC660_26790	COG1388	LysM domain
HC660_26790	COG3584	3D domain protein
HC660_26800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HC660_26830	COG0756	dUTP diphosphatase activity
HC660_26840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC660_26860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC660_26920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC660_26920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC660_27030	COG1484	DNA-dependent DNA replication
HC660_27130	COG0622	Phosphoesterase
HC660_27140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HC660_27150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HC660_27160	COG5401	PFAM Sporulation and spore germination
HC660_27170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC660_27180	COG1846	Transcriptional regulator
HC660_27190	COG2197	response regulator
HC660_27200	COG0824	Thioesterase
HC660_27210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC660_27220	COG1053	succinate dehydrogenase
HC660_27230	COG2009	succinate dehydrogenase
HC660_27240	COG1719	4-vinyl reductase, 4VR
HC660_27250	COG0527	aspartate kinase activity
HC660_27260	COG0322	excinuclease ABC activity
HC660_27270	COG3118	belongs to the thioredoxin family
HC660_27280	COG3534	alpha-L-arabinofuranosidase
HC660_27290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HC660_27300	COG2086	electron transfer activity
HC660_27310	COG1024	Enoyl-CoA hydratase
HC660_27320	COG1309	transcriptional regulator
HC660_27330	COG0318	PFAM AMP-dependent synthetase and ligase
HC660_27340	COG3766	membrane
HC660_27350	COG1193	negative regulation of DNA recombination
HC660_27360	COG1796	DNA polymerase
HC660_27360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC660_27370	COG1286	toxin biosynthetic process
HC660_27380	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HC660_27390	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC660_27400	COG0072	phenylalanine-tRNA ligase activity
HC660_27400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC660_27410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HC660_27420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC660_27440	COG3835	regulator
HC660_27450	COG0277	FAD linked oxidase domain protein
HC660_27460	COG0247	lactate metabolic process
HC660_27470	COG0346	lactoylglutathione lyase activity
HC660_27480	COG1966	Carbon starvation protein
HC660_27490	COG3534	alpha-L-arabinofuranosidase
HC660_27500	COG0395	ABC-type sugar transport system, permease component
HC660_27510	COG1175	transmembrane transport
HC660_27520	COG1653	transport
HC660_27530	COG0371	Dehydrogenase
HC660_27540	COG0647	UMP catabolic process
HC660_27550	COG0235	Class ii aldolase
HC660_27560	COG1069	ribulokinase activity
HC660_27570	COG2160	L-arabinose isomerase activity
HC660_27580	COG3507	Belongs to the glycosyl hydrolase 43 family
HC660_27600	COG1363	Peptidase, m42
HC660_27620	COG3326	Membrane
HC660_27630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HC660_27640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HC660_27650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HC660_27680	COG1346	cytolysis
HC660_27690	COG1380	Effector of murein hydrolase LrgA
HC660_27700	COG3279	Response regulator of the LytR AlgR family
HC660_27710	COG3275	phosphorelay sensor kinase activity
HC660_27720	COG1011	Hydrolase
HC660_27730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC660_27750	COG0398	Pfam SNARE associated Golgi protein
HC660_27760	COG1484	DNA-dependent DNA replication
HC660_27770	COG3611	Membrane attachment protein
HC660_27780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HC660_27790	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HC660_27800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC660_27810	COG1733	regulation of RNA biosynthetic process
HC660_27820	COG2814	Major facilitator Superfamily
HC660_27830	COG0656	L-ascorbic acid biosynthetic process
HC660_27840	COG0237	dephospho-CoA kinase activity
HC660_27850	COG1971	Probably functions as a manganese efflux pump
HC660_27860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC660_27870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC660_27870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC660_27880	COG5002	protein histidine kinase activity
HC660_27890	COG0745	RESPONSE REGULATOR receiver
HC660_27900	COG0039	L-malate dehydrogenase activity
HC660_27910	COG0538	isocitrate dehydrogenase activity
HC660_27920	COG0372	Belongs to the citrate synthase family
HC660_27930	COG2707	UPF0756 membrane protein
HC660_27940	COG0628	permease
HC660_27950	COG3030	protein affecting phage T7 exclusion by the F plasmid
HC660_27960	COG0469	pyruvate kinase activity
HC660_27970	COG0205	6-phosphofructokinase activity
HC660_27980	COG0825	malonyl-CoA metabolic process
HC660_27990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HC660_28000	COG0281	malic enzyme
HC660_28010	COG0587	DNA-directed DNA polymerase activity
HC660_28050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HC660_28070	COG4109	DRTGG domain
HC660_28080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC660_28090	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_28100	COG0165	Argininosuccinate lyase
HC660_28110	COG0137	argininosuccinate synthase activity
HC660_28120	COG0521	Mo-molybdopterin cofactor biosynthetic process
HC660_28130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HC660_28140	COG0827	DNA restriction-modification system
HC660_28150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HC660_28160	COG3874	Sporulation protein YtfJ
HC660_28180	COG1714	RDD family
HC660_28190	COG0616	signal peptide processing
HC660_28200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC660_28210	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HC660_28220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC660_28240	COG0301	tRNA thio-modification
HC660_28250	COG1104	cysteine desulfurase activity
HC660_28260	COG1114	Component of the transport system for branched-chain amino acids
HC660_28270	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HC660_28280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC660_28290	COG1309	transcriptional regulator
HC660_28300	COG1956	GAF domain-containing protein
HC660_28310	COG2199	diguanylate cyclase activity
HC660_28310	COG2203	Gaf domain
HC660_28330	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HC660_28340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC660_28350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC660_28360	COG0454	-acetyltransferase
HC660_28370	COG0517	IMP dehydrogenase activity
HC660_28380	COG0123	including yeast histone deacetylase and acetoin utilization protein
HC660_28390	COG1360	Flagellar Motor Protein
HC660_28400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC660_28410	COG1609	Transcriptional regulator
HC660_28420	COG1605	Chorismate mutase
HC660_28420	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HC660_28430	COG3118	belongs to the thioredoxin family
HC660_28440	COG4980	gas vesicle protein
HC660_28450	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC660_28460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC660_28470	COG1674	ftsk spoiiie
HC660_28480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC660_28490	COG4848	Belongs to the UPF0354 family
HC660_28500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC660_28520	COG1363	Peptidase, m42
HC660_28530	COG5584	Small secreted protein
HC660_28540	COG0281	malic enzyme
HC660_28550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC660_28560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HC660_28580	COG0510	thiamine kinase activity
HC660_28590	COG1523	belongs to the glycosyl hydrolase 13 family
HC660_28600	COG1597	lipid kinase activity
HC660_28620	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC660_28630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC660_28640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC660_28650	COG2252	PERMEase
HC660_28660	COG4473	ABC transporter
HC660_28670	COG1131	(ABC) transporter
HC660_28680	COG1349	DNA-binding transcription factor activity
HC660_28690	COG1187	pseudouridine synthase activity
HC660_28700	COG2244	polysaccharide biosynthetic process
HC660_28710	COG2081	HI0933 family
HC660_28720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC660_28740	COG5578	integral membrane protein
HC660_28750	COG0673	inositol 2-dehydrogenase activity
HC660_28760	COG1653	transport
HC660_28770	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC660_28780	COG4209	transmembrane transport
HC660_28790	COG2207	Transcriptional regulator
HC660_28800	COG1653	transport
HC660_28810	COG0395	ABC-type sugar transport system, permease component
HC660_28820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC660_28830	COG2124	cytochrome p450
HC660_28860	COG0156	8-amino-7-oxononanoate synthase activity
HC660_28870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC660_28890	COG1073	alpha beta
HC660_28900	COG1609	Transcriptional regulator
HC660_28910	COG1653	transport
HC660_28920	COG1175	transmembrane transport
HC660_28930	COG0395	ABC-type sugar transport system, permease component
HC660_28940	COG1486	melibiose metabolic process
HC660_28950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC660_28960	COG0495	leucyl-tRNA aminoacylation
HC660_28980	COG1366	Belongs to the anti-sigma-factor antagonist family
HC660_28980	COG2202	Pas domain
HC660_28990	COG2814	Major facilitator Superfamily
HC660_29000	COG2433	Pfam Transposase IS66
HC660_29010	COG0577	efflux transmembrane transporter activity
HC660_29020	COG1136	(ABC) transporter
HC660_29030	COG2205	protein histidine kinase activity
HC660_29040	COG0745	RESPONSE REGULATOR receiver
HC660_29050	COG0577	efflux transmembrane transporter activity
HC660_29060	COG1136	(ABC) transporter
HC660_29090	COG1131	(ABC) transporter
HC660_29100	COG1725	Transcriptional regulator
HC660_29120	COG1242	4 iron, 4 sulfur cluster binding
HC660_29130	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HC660_29150	COG2267	carboxylic ester hydrolase activity
HC660_29160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC660_29170	COG1113	amino acid transport
HC660_29180	COG0367	asparagine synthase
HC660_29190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HC660_29200	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HC660_29220	COG1506	peptidase
HC660_29230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC660_29240	COG1116	anion transmembrane transporter activity
HC660_29250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC660_29260	COG0494	nUDIX hydrolase
HC660_29270	COG4824	toxin secretion phage lysis holin
HC660_29280	COG0783	Belongs to the Dps family
HC660_29310	COG1854	S-ribosylhomocysteine lyase activity
HC660_29320	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HC660_29330	COG0288	reversible hydration of carbon dioxide
HC660_29340	COG0254	rRNA binding
HC660_29350	COG1271	oxidase subunit
HC660_29360	COG1294	oxidase, subunit
HC660_29380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC660_29390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC660_29390	COG1321	iron dependent repressor
HC660_29400	COG1121	(ABC) transporter
HC660_29410	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC660_29420	COG4948	Mandelate Racemase Muconate Lactonizing
HC660_29430	COG0318	PFAM AMP-dependent synthetase and ligase
HC660_29440	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HC660_29450	COG0596	Alpha beta hydrolase
HC660_29460	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HC660_29470	COG1169	isochorismate synthase
HC660_29480	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC660_29490	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HC660_29500	COG0058	SHG alpha-glucan phosphorylase activity
HC660_29510	COG0297	glycogen (starch) synthase activity
HC660_29520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC660_29530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC660_29540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HC660_29790	COG3859	Proton-coupled thiamine transporter YuaJ
HC660_29800	COG1247	-acetyltransferase
HC660_29810	COG2268	Band 7 protein
HC660_29820	COG1585	Membrane protein implicated in regulation of membrane protease activity
HC660_29830	COG2318	DinB family
HC660_29850	COG1454	alcohol dehydrogenase
HC660_29860	COG1012	belongs to the aldehyde dehydrogenase family
HC660_29870	COG1510	regulation of RNA biosynthetic process
HC660_29890	COG0569	domain protein
HC660_29900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC660_29910	COG4682	membrane
HC660_29920	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC660_29930	COG0477	Major facilitator Superfamily
HC660_29940	COG5553	Cysteine dioxygenase type I
HC660_29960	COG1968	undecaprenyl-diphosphatase activity
HC660_29970	COG0628	permease
HC660_29980	COG0673	inositol 2-dehydrogenase activity
HC660_29990	COG4806	L-rhamnose isomerase
HC660_30000	COG3254	rhamnose metabolic process
HC660_30010	COG1070	Carbohydrate kinase
HC660_30020	COG1349	DNA-binding transcription factor activity
HC660_30030	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_30030	COG3347	Dehydrogenase
HC660_30040	COG0840	transmembrane signaling receptor activity
HC660_30050	COG0840	transmembrane signaling receptor activity
HC660_30060	COG0840	transmembrane signaling receptor activity
HC660_30070	COG0840	transmembrane signaling receptor activity
HC660_30100	COG2070	2-Nitropropane dioxygenase
HC660_30110	COG0432	Pfam Uncharacterised protein family UPF0047
HC660_30120	COG0366	Alpha amylase catalytic
HC660_30130	COG1253	flavin adenine dinucleotide binding
HC660_30140	COG2738	Putative neutral zinc metallopeptidase
HC660_30170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC660_30200	COG0166	Belongs to the GPI family
HC660_30210	COG1979	alcohol dehydrogenase
HC660_30220	COG1979	alcohol dehydrogenase
HC660_30240	COG2155	Conserved Protein
HC660_30250	COG1098	S1 RNA binding domain
HC660_30260	COG0436	Aminotransferase
HC660_30270	COG1522	sequence-specific DNA binding
HC660_30280	COG2267	carboxylic ester hydrolase activity
HC660_30300	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HC660_30310	COG2205	protein histidine kinase activity
HC660_30330	COG5018	Exonuclease
HC660_30350	COG2814	Major facilitator Superfamily
HC660_30360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC660_30370	COG3011	Protein conserved in bacteria
HC660_30390	COG3290	protein histidine kinase activity
HC660_30400	COG4565	transcriptional regulatory protein
HC660_30450	COG3493	citrate carrier protein
HC660_30470	COG2111	Na H antiporter
HC660_30470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC660_30480	COG2111	Na H antiporter
HC660_30490	COG1006	Multisubunit Na H antiporter MnhC subunit
HC660_30500	COG0651	ATP synthesis coupled electron transport
HC660_30510	COG1863	multisubunit Na H antiporter MnhE subunit
HC660_30520	COG2212	antiporter activity
HC660_30530	COG1320	monovalent cation:proton antiporter activity
HC660_30540	COG2050	protein possibly involved in aromatic compounds catabolism
HC660_30550	COG2197	response regulator
HC660_30560	COG4585	Histidine kinase
HC660_30580	COG0142	geranyltranstransferase activity
HC660_30600	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HC660_30610	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HC660_30620	COG1335	isochorismatase
HC660_30630	COG5506	Protein of unknown function (DUF1694)
HC660_30660	COG0628	permease
HC660_30680	COG1418	mRNA catabolic process
HC660_30690	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_30710	COG1511	domain protein
HC660_30720	COG1674	ftsk spoiiie
HC660_30720	COG0433	COG0433 Predicted ATPase
HC660_30730	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC660_30740	COG5417	Belongs to the EsaB family
HC660_30750	COG4842	Belongs to the WXG100 family
HC660_30770	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC660_30770	COG2508	Transcriptional regulator
HC660_30780	COG0686	Belongs to the AlaDH PNT family
HC660_30790	COG5634	Uncharacterized conserved protein (DUF2278)
HC660_30800	COG3251	PFAM MbtH domain protein
HC660_30810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC660_30820	COG1535	isochorismatase
HC660_30820	COG3433	isochorismatase activity
HC660_30830	COG1021	2,3-dihydroxybenzoate-AMP ligase
HC660_30840	COG1169	isochorismate synthase
HC660_30850	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_30860	COG2819	hydrolase of the alpha beta superfamily
HC660_30870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC660_30880	COG1268	BioY protein
HC660_30890	COG2056	Na+-H+ antiporter family
HC660_30900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HC660_30910	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HC660_30920	COG3584	3D domain protein
HC660_30940	COG1252	NADH dehydrogenase
HC660_30950	COG0492	ferredoxin-NADP+ reductase activity
HC660_30970	COG0516	GMP reductase activity
HC660_30980	COG0316	Belongs to the HesB IscA family
HC660_30990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HC660_31000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC660_31010	COG4844	belongs to the
HC660_31020	COG1252	NADH dehydrogenase
HC660_31030	COG4837	Protein of unknown function (DUF1462)
HC660_31040	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HC660_31050	COG1506	peptidase
HC660_31050	COG4946	Tricorn protease homolog
HC660_31050	COG0823	Involved in the tonB-independent uptake of proteins
HC660_31060	COG0083	homoserine kinase activity
HC660_31070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HC660_31080	COG0460	homoserine dehydrogenase
HC660_31090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC660_31100	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC660_31110	COG0647	UMP catabolic process
HC660_31120	COG2445	Protein of unknown function DUF86
HC660_31130	COG4470	Protein conserved in bacteria
HC660_31160	COG0739	heme binding
HC660_31180	COG3377	Domain of unknown function (DUF1805)
HC660_31190	COG0737	Belongs to the 5'-nucleotidase family
HC660_31200	COG0730	response to heat
HC660_31210	COG1801	Protein of unknown function DUF72
HC660_31230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC660_31240	COG2508	Transcriptional regulator
HC660_31250	COG2233	PERMEase
HC660_31260	COG2233	PERMEase
HC660_31270	COG3195	allantoin biosynthetic process
HC660_31270	COG3648	Uricase
HC660_31280	COG2351	hydroxyisourate hydrolase activity
HC660_31290	COG2080	2 iron, 2 sulfur cluster binding
HC660_31300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HC660_31310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HC660_31320	COG2068	MobA-Related Protein
HC660_31330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HC660_31340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HC660_31350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC660_31360	COG2356	endonuclease I
HC660_31370	COG3842	ATPase activity
HC660_31380	COG2188	Transcriptional regulator
HC660_31390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC660_31400	COG0395	ABC-type sugar transport system, permease component
HC660_31410	COG1175	transmembrane transport
HC660_31420	COG1653	transport
HC660_31430	COG2222	sugar isomerase
HC660_31440	COG0322	excinuclease ABC activity
HC660_31450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC660_31480	COG0719	Fe-S assembly protein
HC660_31490	COG0822	iron-sulfur transferase activity
HC660_31500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC660_31510	COG0719	Fe-S assembly protein
HC660_31520	COG0396	ATPase activity
HC660_31540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC660_31550	COG1464	Belongs to the NlpA lipoprotein family
HC660_31560	COG2011	ABC-type metal ion transport system permease component
HC660_31570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC660_31590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC660_31600	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC660_31620	COG0509	glycine decarboxylation via glycine cleavage system
HC660_31630	COG1393	Belongs to the ArsC family
HC660_31640	COG1960	acyl-CoA dehydrogenase activity
HC660_31650	COG0183	Belongs to the thiolase family
HC660_31660	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC660_31660	COG1024	Enoyl-CoA hydratase
HC660_31670	COG0506	proline dehydrogenase activity
HC660_31690	COG5577	PFAM Coat F domain
HC660_31700	COG1846	Transcriptional regulator
HC660_31710	COG0477	Major facilitator Superfamily
HC660_31720	COG1942	4-Oxalocrotonate Tautomerase
HC660_31730	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_31740	COG0583	DNA-binding transcription factor activity
HC660_31760	COG1120	ATPase activity
HC660_31790	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_31800	COG0783	Belongs to the Dps family
HC660_31810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC660_31820	COG0745	RESPONSE REGULATOR receiver
HC660_31830	COG2205	protein histidine kinase activity
HC660_31830	COG2770	Histidine kinase
HC660_31850	COG1309	transcriptional regulator
HC660_31860	COG0114	fumarate hydratase activity
HC660_31880	COG0697	spore germination
HC660_31890	COG0814	amino acid
HC660_31910	COG2197	response regulator
HC660_31920	COG4585	Histidine kinase
HC660_31930	COG4758	membrane
HC660_31940	COG3595	metallopeptidase activity
HC660_31950	COG1842	Phage shock protein A
HC660_31960	COG4758	membrane
HC660_31970	COG2814	Major facilitator Superfamily
HC660_31980	COG2096	Adenosyltransferase
HC660_31990	COG1120	ATPase activity
HC660_32000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC660_32010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC660_32020	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_32030	COG3386	PFAM SMP-30 Gluconolaconase
HC660_32040	COG2205	protein histidine kinase activity
HC660_32050	COG0745	RESPONSE REGULATOR receiver
HC660_32070	COG1191	sigma factor activity
HC660_32090	COG2140	Oxalate decarboxylase
HC660_32110	COG0577	efflux transmembrane transporter activity
HC660_32120	COG1136	(ABC) transporter
HC660_32130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC660_32140	COG1120	ATPase activity
HC660_32150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC660_32160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC660_32170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC660_32180	COG0531	amino acid
HC660_32200	COG1988	membrane-bound metal-dependent
HC660_32210	COG1368	sulfuric ester hydrolase activity
HC660_32220	COG1910	domain protein
HC660_32230	COG0725	ABC transporter, periplasmic molybdate-binding protein
HC660_32240	COG4149	molybdate abc transporter
HC660_32250	COG0656	L-ascorbic acid biosynthetic process
HC660_32270	COG0025	NhaP-type Na H and K H
HC660_32280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC660_32290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC660_32300	COG3973	AAA domain
HC660_32310	COG2860	membrane
HC660_32320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HC660_32330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC660_32340	COG2217	Heavy metal translocating P-type atpase
HC660_32350	COG2217	Heavy metal translocating P-type atpase
HC660_32360	COG2608	mercury ion transmembrane transporter activity
HC660_32370	COG1937	Protein conserved in bacteria
HC660_32380	COG0673	inositol 2-dehydrogenase activity
HC660_32390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC660_32400	COG1289	transmembrane transporter activity
HC660_32410	COG1802	Transcriptional regulator
HC660_32420	COG0697	spore germination
HC660_32440	COG2076	Multidrug Resistance protein
HC660_32450	COG1309	transcriptional regulator
HC660_32460	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_32470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HC660_32480	COG0557	exoribonuclease II activity
HC660_32490	COG1647	Serine aminopeptidase, S33
HC660_32500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC660_32510	COG0596	Alpha beta hydrolase
HC660_32520	COG1476	TRANSCRIPTIONal
HC660_32530	COG1396	sequence-specific DNA binding
HC660_32540	COG1396	sequence-specific DNA binding
HC660_32550	COG1733	regulation of RNA biosynthetic process
HC660_32600	COG1131	(ABC) transporter
HC660_32650	COG1174	glycine betaine transport
HC660_32660	COG1732	Glycine betaine
HC660_32670	COG1174	glycine betaine transport
HC660_32680	COG0517	IMP dehydrogenase activity
HC660_32680	COG1125	glycine betaine transport
HC660_32690	COG1510	regulation of RNA biosynthetic process
HC660_32700	COG1174	glycine betaine transport
HC660_32710	COG1732	Glycine betaine
HC660_32720	COG1174	glycine betaine transport
HC660_32730	COG1125	glycine betaine transport
HC660_32730	COG0517	IMP dehydrogenase activity
HC660_32740	COG1510	regulation of RNA biosynthetic process
HC660_32760	COG3064	Membrane
HC660_32770	COG4640	response to antibiotic
HC660_32780	COG0456	acetyltransferase
HC660_32800	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HC660_32810	COG0149	triose-phosphate isomerase activity
HC660_32820	COG0126	phosphoglycerate kinase activity
HC660_32830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC660_32840	COG2390	Transcriptional regulator
HC660_32850	COG2814	Major facilitator Superfamily
HC660_32860	COG1609	Transcriptional regulator
HC660_32870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC660_32880	COG0583	DNA-binding transcription factor activity
HC660_32890	COG0697	spore germination
HC660_32900	COG1113	amino acid transport
HC660_32910	COG3858	chitin binding
HC660_32920	COG1556	Lactate utilization protein
HC660_32930	COG1139	Iron-sulfur cluster binding protein
HC660_32940	COG0247	lactate metabolic process
HC660_32950	COG2197	response regulator
HC660_32960	COG4585	Histidine kinase
HC660_32970	COG0842	Transport permease protein
HC660_32980	COG1131	(ABC) transporter
HC660_32990	COG0596	Alpha beta hydrolase
HC660_33000	COG2208	phosphoserine phosphatase activity
HC660_33010	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HC660_33020	COG1874	Beta-galactosidase
HC660_33030	COG3833	ABC-type maltose transport systems, permease component
HC660_33040	COG1175	transmembrane transport
HC660_33050	COG2182	Extracellular solute-binding protein
HC660_33060	COG1609	Transcriptional regulator
HC660_33070	COG2186	Transcriptional regulator
HC660_33080	COG1620	l-lactate permease
HC660_33090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HC660_33110	COG5039	Polysaccharide pyruvyl transferase
HC660_33120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC660_33130	COG0110	maltose O-acetyltransferase activity
HC660_33140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC660_33150	COG2244	polysaccharide biosynthetic process
HC660_33160	COG1216	Glycosyl transferase, family 2
HC660_33170	COG5039	Polysaccharide pyruvyl transferase
HC660_33180	COG1216	Glycosyl transferase, family 2
HC660_33200	COG0438	transferase activity, transferring glycosyl groups
HC660_33210	COG1215	transferase activity, transferring glycosyl groups
HC660_33220	COG0438	transferase activity, transferring glycosyl groups
HC660_33230	COG1086	Polysaccharide biosynthesis protein
HC660_33240	COG0489	protein tyrosine kinase activity
HC660_33250	COG3944	biosynthesis protein
HC660_33260	COG1396	sequence-specific DNA binding
HC660_33270	COG2272	Belongs to the type-B carboxylesterase lipase family
HC660_33280	COG3479	Phenolic acid decarboxylase
HC660_33300	COG1794	racemase activity, acting on amino acids and derivatives
HC660_33310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC660_33340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC660_33350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC660_33360	COG0640	Transcriptional regulator
HC660_33370	COG1621	beta-fructofuranosidase activity
HC660_33380	COG1621	beta-fructofuranosidase activity
HC660_33390	COG0531	amino acid
HC660_33400	COG1309	transcriptional regulator
HC660_33410	COG2076	Multidrug Resistance protein
HC660_33420	COG2076	Multidrug Resistance protein
HC660_33460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC660_33470	COG1609	Transcriptional regulator
HC660_33480	COG1611	Belongs to the LOG family
HC660_33490	COG1694	Mazg nucleotide pyrophosphohydrolase
HC660_33500	COG0659	secondary active sulfate transmembrane transporter activity
HC660_33510	COG0288	reversible hydration of carbon dioxide
HC660_33520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC660_33530	COG0577	efflux transmembrane transporter activity
HC660_33540	COG1136	(ABC) transporter
HC660_33550	COG5002	protein histidine kinase activity
HC660_33560	COG0745	RESPONSE REGULATOR receiver
HC660_33580	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HC660_33590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC660_33600	COG1481	regulation of sporulation
HC660_33610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HC660_33620	COG1660	Displays ATPase and GTPase activities
HC660_33630	COG1051	belongs to the nudix hydrolase family
HC660_33640	COG0492	ferredoxin-NADP+ reductase activity
HC660_33650	COG3883	PFAM NLP P60 protein
HC660_33650	COG0791	NLP P60 protein
HC660_33660	COG0457	Tetratricopeptide repeat
HC660_33670	COG1132	(ABC) transporter
HC660_33710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HC660_33710	COG0140	phosphoribosyl-ATP diphosphatase activity
HC660_33720	COG0107	imidazoleglycerol-phosphate synthase activity
HC660_33730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HC660_33740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HC660_33750	COG0131	Imidazoleglycerol-phosphate dehydratase
HC660_33760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HC660_33770	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HC660_33780	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HC660_33790	COG4990	cell redox homeostasis
HC660_33800	COG5297	Belongs to the glycosyl hydrolase family 6
HC660_33810	COG0110	maltose O-acetyltransferase activity
HC660_33820	COG0546	phosphoglycolate phosphatase activity
HC660_33830	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HC660_33840	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HC660_33850	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HC660_33860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC660_33870	COG0363	glucosamine-6-phosphate deaminase activity
HC660_33880	COG2188	Transcriptional regulator
HC660_33890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC660_33900	COG1846	Transcriptional regulator
HC660_33910	COG2124	cytochrome p450
HC660_33930	COG1846	Transcriptional regulator
HC660_33940	COG2814	Major facilitator Superfamily
HC660_33950	COG1950	PFAM Membrane protein of
HC660_33960	COG1983	PspC domain protein
HC660_33970	COG3595	metallopeptidase activity
HC660_34000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC660_34020	COG4897	Protein conserved in bacteria
HC660_34030	COG0574	Belongs to the PEP-utilizing enzyme family
HC660_34030	COG3848	Pyruvate phosphate dikinase
HC660_34040	COG1309	transcriptional regulator
HC660_34050	COG2814	Major facilitator Superfamily
HC660_34060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC660_34080	COG0793	Belongs to the peptidase S41A family
HC660_34080	COG3409	Peptidoglycan-binding domain 1 protein
HC660_34090	COG2177	Part of the ABC transporter FtsEX involved in
HC660_34100	COG2884	Cell division ATP-binding protein ftsE
HC660_34110	COG2010	Cytochrome c
HC660_34120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC660_34130	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HC660_34140	COG0653	protein targeting
HC660_34150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC660_34180	COG1516	flagellar protein fliS
HC660_34190	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HC660_34200	COG1334	flagellar protein FlaG
HC660_34210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC660_34220	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HC660_34230	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HC660_34250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC660_34260	COG4786	Flagellar basal body rod
HC660_34260	COG1256	bacterial-type flagellum assembly
HC660_34270	COG3418	PFAM FlgN family protein
HC660_34280	COG2747	anti-sigma28 factor FlgM
HC660_34300	COG1040	competence protein
HC660_34320	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HC660_34330	COG1307	EDD domain protein, DegV family
HC660_34340	COG2197	response regulator
HC660_34350	COG4585	Histidine kinase
HC660_34360	COG1739	Uncharacterized protein family UPF0029
HC660_34370	COG1316	TRANSCRIPTIONal
HC660_34380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC660_34390	COG0438	transferase activity, transferring glycosyl groups
HC660_34400	COG1215	transferase activity, transferring glycosyl groups
HC660_34410	COG3206	protein involved in exopolysaccharide biosynthesis
HC660_34420	COG3307	-O-antigen
HC660_34430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC660_34440	COG0438	transferase activity, transferring glycosyl groups
HC660_34440	COG0297	glycogen (starch) synthase activity
HC660_34450	COG2244	polysaccharide biosynthetic process
HC660_34480	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC660_34480	COG2247	cell wall binding repeat
HC660_34490	COG2385	sporulation resulting in formation of a cellular spore
HC660_34490	COG2247	cell wall binding repeat
HC660_34510	COG1316	TRANSCRIPTIONal
HC660_34520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HC660_34560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC660_34570	COG1134	teichoic acid transport
HC660_34580	COG1682	transport, permease protein
HC660_34620	COG0463	Glycosyl transferase, family 2
HC660_34710	COG4193	domain, Protein
HC660_34720	COG1482	cell wall glycoprotein biosynthetic process
HC660_34730	COG0697	spore germination
HC660_34740	COG0814	amino acid
HC660_34760	COG2814	Major facilitator Superfamily
HC660_34770	COG1316	TRANSCRIPTIONal
HC660_34780	COG0561	phosphatase activity
HC660_34790	COG0791	NLP P60 protein
HC660_34810	COG2843	Capsule synthesis protein
HC660_34830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC660_34840	COG1609	Transcriptional regulator
HC660_34850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC660_34860	COG1869	D-ribose catabolic process
HC660_34870	COG1129	ABC transporter
HC660_34880	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC660_34890	COG1879	ABC-type sugar transport system periplasmic component
HC660_34900	COG3103	Sh3 type 3 domain protein
HC660_34920	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC660_34930	COG3527	Alpha-acetolactate decarboxylase
HC660_34940	COG0028	Belongs to the TPP enzyme family
HC660_34950	COG0583	DNA-binding transcription factor activity
HC660_34960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC660_34990	COG5337	Spore coat protein CotH
HC660_35010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC660_35020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC660_35050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC660_35070	COG0405	Gamma-glutamyltransferase
HC660_35080	COG1522	sequence-specific DNA binding
HC660_35090	COG2059	Chromate
HC660_35100	COG2059	Chromate
HC660_35130	COG5444	nuclease activity
HC660_35170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC660_35180	COG4464	protein tyrosine phosphatase activity
HC660_35190	COG0489	protein tyrosine kinase activity
HC660_35200	COG3944	biosynthesis protein
HC660_35210	COG4715	Zinc finger, swim domain protein
HC660_35220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC660_35230	COG0561	phosphatase activity
HC660_35240	COG1349	DNA-binding transcription factor activity
HC660_35250	COG0629	single-stranded DNA binding
HC660_35280	COG2602	Beta-lactamase
HC660_35290	COG3764	Sortase (surface protein transpeptidase)
HC660_35310	COG3279	Response regulator of the LytR AlgR family
HC660_35320	COG2972	Histidine kinase
HC660_35320	COG0745	RESPONSE REGULATOR receiver
HC660_35330	COG1970	mechanosensitive ion channel activity
HC660_35340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC660_35350	COG0457	Tetratricopeptide repeat
HC660_35360	COG4786	Flagellar basal body rod
HC660_35370	COG4786	Flagellar basal body rod
HC660_35380	COG1077	Cell shape determining protein MreB Mrl
HC660_35390	COG1609	Transcriptional regulator
HC660_35400	COG1846	Transcriptional regulator
HC660_35410	COG2814	Major facilitator Superfamily
HC660_35420	COG3420	alginic acid biosynthetic process
HC660_35430	COG1953	Uracil, thiamine, allantoin
HC660_35440	COG0477	Major facilitator Superfamily
HC660_35450	COG1335	isochorismatase
HC660_35470	COG0004	ammonium transporteR
HC660_35480	COG0347	Belongs to the P(II) protein family
HC660_35490	COG0671	phosphoesterase, PA-phosphatase related
HC660_35510	COG0739	heme binding
HC660_35520	COG1247	-acetyltransferase
HC660_35540	COG1086	Polysaccharide biosynthesis protein
HC660_35550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC660_35570	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HC660_35600	COG2089	acid synthase
HC660_35620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC660_35640	COG2910	NAD(P)H-binding
HC660_35650	COG1959	2 iron, 2 sulfur cluster binding
HC660_35660	COG0804	urea catabolic process
HC660_35670	COG0832	Belongs to the urease beta subunit family
HC660_35680	COG0831	urea catabolic process
HC660_35740	COG3237	CsbD-like
HC660_35750	COG1994	Peptidase M50
HC660_35760	COG0457	Tetratricopeptide repeat
HC660_35770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HC660_35780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HC660_35800	COG2304	oxidoreductase activity
HC660_35810	COG2304	oxidoreductase activity
HC660_35820	COG2385	sporulation resulting in formation of a cellular spore
HC660_35830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC660_35850	COG4836	Membrane
HC660_35870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HC660_35880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HC660_35890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HC660_35910	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC660_35920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HC660_35940	COG0356	it plays a direct role in the translocation of protons across the membrane
HC660_35960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HC660_35970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HC660_35980	COG4475	Protein of unknown function (DUF436)
HC660_35990	COG0698	ribose 5-phosphate isomerase
HC660_36000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC660_36010	COG1971	Probably functions as a manganese efflux pump
HC660_36020	COG0009	L-threonylcarbamoyladenylate synthase
HC660_36030	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HC660_36070	COG2890	protein-(glutamine-N5) methyltransferase activity
HC660_36080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HC660_36090	COG0346	lactoylglutathione lyase activity
HC660_36100	COG0789	Transcriptional regulator
HC660_36110	COG0679	Auxin Efflux Carrier
HC660_36120	COG0281	malic enzyme
HC660_36130	COG1435	thymidine kinase activity
HC660_36150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HC660_36170	COG1494	fructose-1,6-bisphosphatase
HC660_36180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC660_36190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC660_36200	COG0191	fructose-bisphosphate aldolase activity
HC660_36210	COG2204	response regulator
HC660_36220	COG4821	SIS domain
HC660_36230	COG0504	CTP synthase activity
HC660_36240	COG3343	RNA polymerase activity
HC660_36250	COG1960	acyl-CoA dehydrogenase activity
HC660_36260	COG0247	lactate metabolic process
HC660_36260	COG2181	nitrate reductase activity
HC660_36270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC660_36280	COG4294	response to UV
HC660_36300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC660_36310	COG1132	(ABC) transporter
HC660_36320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC660_36340	COG2181	nitrate reductase activity
HC660_36350	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC660_36360	COG1140	nitrate reductase beta subunit
HC660_36370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC660_36380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC660_36400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC660_36410	COG2223	nitrite transmembrane transporter activity
HC660_36420	COG0018	arginyl-trna synthetase
HC660_36430	COG4506	Protein conserved in bacteria
HC660_36450	COG0535	radical SAM domain protein
HC660_36470	COG1131	(ABC) transporter
HC660_36490	COG0612	Peptidase, M16
HC660_36520	COG3391	amine dehydrogenase activity
HC660_36530	COG3391	amine dehydrogenase activity
HC660_36540	COG0457	Tetratricopeptide repeat
HC660_36550	COG0010	Belongs to the arginase family
HC660_36560	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HC660_36570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC660_36600	COG1994	Peptidase M50
HC660_36610	COG1942	4-Oxalocrotonate Tautomerase
HC660_36620	COG1846	Transcriptional regulator
HC660_36630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC660_36650	COG0477	Major facilitator Superfamily
HC660_36660	COG1959	2 iron, 2 sulfur cluster binding
HC660_36670	COG3465	dGTPase activity
HC660_36680	COG1078	dGTPase activity
HC660_36690	COG4844	belongs to the
HC660_36710	COG0697	spore germination
HC660_36720	COG0095	Lipoate-protein ligase
HC660_36730	COG0583	DNA-binding transcription factor activity
HC660_36740	COG0280	phosphate acetyltransferase
HC660_36760	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_36770	COG0436	Aminotransferase
HC660_36780	COG2814	Major facilitator Superfamily
HC660_36790	COG0151	Belongs to the GarS family
HC660_36800	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_36810	COG1917	Cupin 2, conserved barrel domain protein
HC660_36820	COG0077	Prephenate dehydratase
HC660_36830	COG2814	Major facilitator Superfamily
HC660_36840	COG2814	Major facilitator Superfamily
HC660_36850	COG0833	amino acid
HC660_36860	COG4187	Peptidase family M20/M25/M40
HC660_36870	COG1012	belongs to the aldehyde dehydrogenase family
HC660_36880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC660_36900	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HC660_36910	COG1091	dTDP-4-dehydrorhamnose reductase activity
HC660_36920	COG1088	dTDP-glucose 4,6-dehydratase activity
HC660_36930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC660_36940	COG0456	acetyltransferase
HC660_36950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC660_36960	COG0463	Glycosyl transferase, family 2
HC660_36980	COG2363	Small membrane protein
HC660_36990	COG2233	PERMEase
HC660_37010	COG1012	belongs to the aldehyde dehydrogenase family
HC660_37020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HC660_37030	COG1216	Glycosyl transferase, family 2
HC660_37060	COG1695	Transcriptional regulator
HC660_37070	COG0351	phosphomethylpyrimidine kinase
HC660_37090	COG1621	beta-fructofuranosidase activity
HC660_37100	COG1263	PTS System
HC660_37100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC660_37110	COG2116	formate transmembrane transporter activity
HC660_37120	COG3711	transcriptional antiterminator
HC660_37140	COG1404	Belongs to the peptidase S8 family
HC660_37150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC660_37160	COG0778	Nitroreductase
HC660_37170	COG0772	Belongs to the SEDS family
HC660_37210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC660_37220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC660_37230	COG2261	transglycosylase associated protein
HC660_37240	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HC660_37250	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HC660_37260	COG2246	polysaccharide biosynthetic process
HC660_37270	COG1309	transcriptional regulator
HC660_37300	COG3162	membrane
HC660_37310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC660_37320	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HC660_37330	COG2837	iron assimilation
HC660_37340	COG2822	iron ion transport
HC660_37350	COG0672	)-iron permease
HC660_37360	COG0352	thiamine-phosphate diphosphorylase activity
HC660_37370	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HC660_37380	COG0583	DNA-binding transcription factor activity
HC660_37390	COG1380	Effector of murein hydrolase LrgA
HC660_37400	COG1346	cytolysis
HC660_37410	COG1131	(ABC) transporter
HC660_37460	COG1346	cytolysis
HC660_37470	COG4895	conserved protein (DUF2196)
HC660_37480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HC660_37490	COG0346	lactoylglutathione lyase activity
HC660_37510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC660_37520	COG1404	Belongs to the peptidase S8 family
HC660_37530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC660_37530	COG1263	PTS System
HC660_37540	COG3711	transcriptional antiterminator
HC660_37550	COG1442	glycosyl transferase family 8
HC660_37560	COG5522	Integral membrane protein (intg_mem_TP0381)
HC660_37570	COG1846	Transcriptional regulator
HC660_37580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC660_37590	COG2234	aminopeptidase activity
HC660_37600	COG2357	RelA SpoT domain protein
HC660_37610	COG1575	Belongs to the MenA family. Type 1 subfamily
HC660_37620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC660_37630	COG1696	Membrane protein involved in D-alanine export
HC660_37640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC660_37650	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HC660_37660	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HC660_37670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC660_37680	COG1486	melibiose metabolic process
HC660_37690	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC660_37700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC660_37710	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC660_37720	COG3711	transcriptional antiterminator
HC660_37720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC660_37740	COG2094	Belongs to the DNA glycosylase MPG family
HC660_37750	COG0753	catalase activity
HC660_37760	COG2814	Major facilitator Superfamily
HC660_37770	COG2814	Major facilitator Superfamily
HC660_37780	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC660_37790	COG1131	(ABC) transporter
HC660_37830	COG1595	DNA-templated transcription, initiation
HC660_37840	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC660_37850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HC660_37860	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HC660_37870	COG4988	ABC transporter
HC660_37880	COG1294	oxidase, subunit
HC660_37890	COG1271	oxidase subunit
HC660_37900	COG3493	citrate carrier protein
HC660_37910	COG0501	Belongs to the peptidase M48B family
HC660_37920	COG0726	polysaccharide deacetylase
HC660_37940	COG3842	ATPase activity
HC660_37950	COG2508	Transcriptional regulator
HC660_37960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC660_37980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HC660_37990	COG1881	PFAM PEBP family protein
HC660_38000	COG0583	DNA-binding transcription factor activity
HC660_38020	COG4585	Histidine kinase
HC660_38030	COG2197	response regulator
HC660_38040	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC660_38060	COG4894	glucomannan catabolic process
HC660_38070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC660_38080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC660_38090	COG3829	transcription factor binding
HC660_38090	COG3290	protein histidine kinase activity
HC660_38100	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_38110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC660_38120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC660_38130	COG2610	gluconate transmembrane transporter activity
HC660_38140	COG0500	methyltransferase
HC660_38150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC660_38180	COG0693	protein deglycase activity
HC660_38180	COG0753	catalase activity
HC660_38190	COG2851	Citrate transporter
HC660_38210	COG2270	Major facilitator Superfamily
HC660_38220	COG0513	Belongs to the DEAD box helicase family
HC660_38230	COG2755	lipolytic protein G-D-S-L family
HC660_38230	COG3401	FG-GAP repeat protein
HC660_38390	COG0697	spore germination
HC660_38400	COG0861	Integral membrane protein TerC family
HC660_38410	COG0589	response to stress
HC660_38420	COG0589	response to stress
HC660_38460	COG5444	nuclease activity
HC660_38490	COG5444	nuclease activity
HC660_38520	COG3507	Belongs to the glycosyl hydrolase 43 family
HC660_38550	COG2986	histidine ammonia-lyase
HC660_38560	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HC660_38570	COG1228	amidohydrolase
HC660_38580	COG0010	Belongs to the arginase family
HC660_38590	COG0833	amino acid
HC660_38600	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HC660_38610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC660_38620	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HC660_38630	COG2390	Transcriptional regulator
HC660_38650	COG3192	ethanolamine utilization protein
HC660_38660	COG2079	MmgE PrpD family protein
HC660_38670	COG1473	amidohydrolase
HC660_38680	COG1126	abc transporter atp-binding protein
HC660_38690	COG0765	amino acid transport
HC660_38700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC660_38710	COG0456	acetyltransferase
HC660_38720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC660_38730	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HC660_38740	COG0561	phosphatase activity
HC660_38800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC660_38810	COG5294	Protein conserved in bacteria
HC660_38820	COG0577	efflux transmembrane transporter activity
HC660_38830	COG1136	(ABC) transporter
HC660_38840	COG2205	protein histidine kinase activity
HC660_38850	COG0745	RESPONSE REGULATOR receiver
HC660_38860	COG0191	fructose-bisphosphate aldolase activity
HC660_38880	COG1082	Xylose isomerase domain protein TIM barrel
HC660_38890	COG0673	inositol 2-dehydrogenase activity
HC660_38900	COG2814	Major facilitator Superfamily
HC660_38910	COG1082	Xylose isomerase domain protein TIM barrel
HC660_38920	COG3962	Belongs to the TPP enzyme family
HC660_38930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC660_38950	COG1012	belongs to the aldehyde dehydrogenase family
HC660_38960	COG1349	DNA-binding transcription factor activity
HC660_38970	COG0667	Aldo Keto reductase
HC660_39000	COG2814	Major facilitator Superfamily
HC660_39010	COG0326	Molecular chaperone. Has ATPase activity
HC660_39030	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_39040	COG1309	transcriptional regulator
HC660_39050	COG1012	belongs to the aldehyde dehydrogenase family
HC660_39070	COG0789	Transcriptional regulator
HC660_39080	COG1714	RDD family
HC660_39090	COG2311	Membrane
HC660_39100	COG1917	Cupin 2, conserved barrel domain protein
HC660_39110	COG1309	transcriptional regulator
HC660_39120	COG1028	Short-chain dehydrogenase reductase Sdr
HC660_39130	COG1846	Transcriptional regulator
HC660_39170	COG5039	Polysaccharide pyruvyl transferase
HC660_39180	COG1929	Belongs to the glycerate kinase type-1 family
HC660_39190	COG1802	Transcriptional regulator
HC660_39200	COG1070	Carbohydrate kinase
HC660_39210	COG2610	gluconate transmembrane transporter activity
HC660_39220	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC660_39230	COG0450	alkyl hydroperoxide reductase
HC660_39240	COG3634	alkyl hydroperoxide reductase activity
HC660_39250	COG2723	6-phospho-beta-galactosidase activity
HC660_39270	COG2188	Transcriptional regulator
HC660_39290	COG1131	(ABC) transporter
HC660_39300	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HC660_39340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HC660_39370	COG1063	alcohol dehydrogenase
HC660_39410	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HC660_39420	COG0456	acetyltransferase
HC660_39430	COG0457	Tetratricopeptide repeat
HC660_39450	COG0010	Belongs to the arginase family
HC660_39460	COG0833	amino acid
HC660_39470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC660_39480	COG3829	transcription factor binding
HC660_39490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC660_39500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HC660_39510	COG4853	Protein conserved in bacteria
HC660_39520	COG4863	YycH protein
HC660_39530	COG5002	protein histidine kinase activity
HC660_39540	COG0745	RESPONSE REGULATOR receiver
HC660_39600	COG0346	lactoylglutathione lyase activity
HC660_39610	COG0305	Participates in initiation and elongation during chromosome replication
HC660_39640	COG3093	addiction module antidote protein HigA
HC660_39650	COG2807	transmembrane transport
HC660_39660	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC660_39670	COG0359	binds to the 23S rRNA
HC660_39680	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HC660_39690	COG4241	membrane
HC660_39710	COG5577	PFAM Coat F domain
HC660_39720	COG1733	regulation of RNA biosynthetic process
HC660_39730	COG1227	inorganic diphosphatase activity
HC660_39750	COG2271	Major facilitator Superfamily
HC660_39770	COG2814	Major facilitator Superfamily
HC660_39780	COG0583	DNA-binding transcription factor activity
HC660_39790	COG2153	protein acetylation
HC660_39810	COG0583	DNA-binding transcription factor activity
HC660_39840	COG0640	Transcriptional regulator
HC660_39850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC660_39880	COG2409	Drug exporters of the RND superfamily
HC660_39890	COG2197	response regulator
HC660_39900	COG4585	Histidine kinase
HC660_39920	COG2315	Protein conserved in bacteria
HC660_39930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC660_39940	COG1331	Highly conserved protein containing a thioredoxin domain
HC660_39960	COG1522	sequence-specific DNA binding
HC660_40000	COG1396	sequence-specific DNA binding
HC660_40010	COG2856	Zn peptidase
HC660_40030	COG1331	Highly conserved protein containing a thioredoxin domain
HC660_40040	COG1266	CAAX protease self-immunity
HC660_40050	COG2814	Major facilitator Superfamily
HC660_40050	COG0477	Major facilitator Superfamily
HC660_40060	COG0110	maltose O-acetyltransferase activity
HC660_40070	COG0346	lactoylglutathione lyase activity
HC660_40080	COG1609	Transcriptional regulator
HC660_40090	COG0708	Exodeoxyribonuclease III
HC660_40110	COG0629	single-stranded DNA binding
HC660_40120	COG0360	Binds together with S18 to 16S ribosomal RNA
HC660_40130	COG0012	GTP binding
HC660_40140	COG0243	molybdopterin cofactor binding
HC660_40150	COG4481	Protein conserved in bacteria
HC660_40160	COG3949	Membrane
HC660_40190	COG1475	DNA binding
HC660_40200	COG1192	Involved in chromosome partitioning
HC660_40220	COG1475	DNA binding
HC660_40230	COG0357	Ribosomal RNA small subunit methyltransferase G
HC660_40240	COG0445	tRNA wobble uridine modification
HC660_40250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HC660_40260	COG1847	R3H domain protein
HC660_40270	COG0706	membrane insertase activity
HC660_40280	COG0594	ribonuclease P activity