locus-tag	class	description
EXW58_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW58_00010	COG0592	DNA-directed DNA polymerase activity
EXW58_00015	COG2501	S4 domain
EXW58_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW58_00025	COG0187	DNA topoisomerase II activity
EXW58_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW58_00065	COG0516	GMP reductase activity
EXW58_00065	COG0517	IMP dehydrogenase activity
EXW58_00070	COG1686	Belongs to the peptidase S11 family
EXW58_00100	COG1428	Deoxynucleoside kinase
EXW58_00105	COG1428	Deoxynucleoside kinase
EXW58_00110	COG1335	isochorismatase
EXW58_00115	COG0590	tRNA wobble adenosine to inosine editing
EXW58_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW58_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW58_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW58_00180	COG1982	Orn Lys Arg decarboxylase major
EXW58_00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW58_00190	COG0470	DNA polymerase III
EXW58_00195	COG1774	PSP1 C-terminal conserved region
EXW58_00200	COG4467	Involved in initiation control of chromosome replication
EXW58_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW58_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW58_00220	COG2002	toxin-antitoxin pair type II binding
EXW58_00230	COG0084	hydrolase, TatD family'
EXW58_00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW58_00250	COG4466	Protein conserved in bacteria
EXW58_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW58_00270	COG0251	oxidation-reduction process
EXW58_00275	COG2088	sporulation resulting in formation of a cellular spore
EXW58_00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW58_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW58_00305	COG2002	toxin-antitoxin pair type II binding
EXW58_00310	COG2244	polysaccharide biosynthetic process
EXW58_00315	COG3956	TIGRFAM MazG family protein
EXW58_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW58_00340	COG1098	S1 RNA binding domain
EXW58_00355	COG2208	phosphoserine phosphatase activity
EXW58_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW58_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW58_00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW58_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW58_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW58_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW58_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW58_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW58_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW58_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW58_00420	COG1396	sequence-specific DNA binding
EXW58_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW58_00520	COG3880	PFAM UvrB UvrC protein
EXW58_00525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW58_00530	COG0542	response to heat
EXW58_00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW58_00540	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW58_00545	COG4956	integral membrane protein (PIN domain superfamily)
EXW58_00550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW58_00560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW58_00565	COG1045	serine acetyltransferase
EXW58_00570	COG0215	cysteine-tRNA ligase activity
EXW58_00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW58_00585	COG3688	RNA-binding protein containing a PIN domain
EXW58_00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW58_00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW58_00605	COG0250	Participates in transcription elongation, termination and antitermination
EXW58_00610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW58_00615	COG0081	regulation of translation
EXW58_00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW58_00625	COG0222	ribosome binding
EXW58_00630	COG2813	Specifically methylates the guanine in position
EXW58_00635	COG0085	RNA polymerase activity
EXW58_00640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW58_00645	COG1358	cellular component organization or biogenesis
EXW58_00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW58_00655	COG0049	tRNA binding
EXW58_00660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW58_00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW58_00670	COG0051	transcription antitermination factor activity, RNA binding
EXW58_00675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW58_00680	COG0088	Forms part of the polypeptide exit tunnel
EXW58_00685	COG0089	rRNA binding
EXW58_00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW58_00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW58_00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW58_00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EXW58_00715	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW58_00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW58_00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EXW58_00730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW58_00735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW58_00745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW58_00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW58_00765	COG1841	ribosomal large subunit assembly
EXW58_00770	COG0200	Binds to the 23S rRNA
EXW58_00775	COG0201	protein transport
EXW58_00780	COG0563	adenylate kinase activity
EXW58_00785	COG0024	Methionine aminopeptidase
EXW58_00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW58_00800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW58_00805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW58_00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW58_00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW58_00845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW58_00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW58_00860	COG0489	protein tyrosine kinase activity
EXW58_00870	COG2194	sulfuric ester hydrolase activity
EXW58_00875	COG0726	polysaccharide deacetylase
EXW58_00955	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW58_00960	COG4856	YbbR-like protein
EXW58_01010	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_01015	COG2011	ABC-type metal ion transport system permease component
EXW58_01025	COG1464	Belongs to the NlpA lipoprotein family
EXW58_01030	COG0604	alcohol dehydrogenase
EXW58_01040	COG0277	FAD linked oxidase domain protein
EXW58_01045	COG2271	Major facilitator Superfamily
EXW58_01055	COG2814	Major facilitator Superfamily
EXW58_01075	COG0601	transmembrane transport
EXW58_01080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW58_01085	COG0444	Belongs to the ABC transporter superfamily
EXW58_01090	COG4608	Belongs to the ABC transporter superfamily
EXW58_01095	COG4166	transmembrane transport
EXW58_01110	COG2207	Transcriptional regulator
EXW58_01125	COG4166	transmembrane transport
EXW58_01130	COG4166	transmembrane transport
EXW58_01135	COG0656	L-ascorbic acid biosynthetic process
EXW58_01140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW58_01150	COG4149	molybdate abc transporter
EXW58_01155	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW58_01160	COG1910	domain protein
EXW58_01175	COG0697	spore germination
EXW58_01190	COG0204	Acyl-transferase
EXW58_01200	COG1609	Transcriptional regulator
EXW58_01210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_01230	COG5298	Protein conserved in bacteria
EXW58_01255	COG0488	(ABC) transporter
EXW58_01270	COG0747	negative chemotaxis
EXW58_01280	COG0601	transmembrane transport
EXW58_01285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW58_01290	COG0444	Belongs to the ABC transporter superfamily
EXW58_01295	COG4608	Belongs to the ABC transporter superfamily
EXW58_01300	COG0561	phosphatase activity
EXW58_01325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW58_01330	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW58_01340	COG0531	amino acid
EXW58_01345	COG2814	Major facilitator Superfamily
EXW58_01355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW58_01365	COG4294	response to UV
EXW58_01370	COG0705	Rhomboid family
EXW58_01375	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW58_01380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW58_01385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW58_01390	COG0864	Transcriptional regulator
EXW58_01395	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW58_01400	COG2183	response to ionizing radiation
EXW58_01500	COG0802	atpase or kinase
EXW58_01505	COG1214	PFAM Peptidase M22, glycoprotease
EXW58_01510	COG0456	acetyltransferase
EXW58_01520	COG0488	(ABC) transporter
EXW58_01525	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW58_01535	COG1266	CAAX protease self-immunity
EXW58_01540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW58_01545	COG0459	protein refolding
EXW58_01550	COG0519	Catalyzes the synthesis of GMP from XMP
EXW58_01550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW58_01555	COG2252	PERMEase
EXW58_01565	COG5002	protein histidine kinase activity
EXW58_01590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW58_01635	COG4187	Peptidase family M20/M25/M40
EXW58_01655	COG2205	protein histidine kinase activity
EXW58_01660	COG0745	RESPONSE REGULATOR receiver
EXW58_01680	COG0697	spore germination
EXW58_01705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW58_01710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW58_01715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW58_01720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW58_01725	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW58_01735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW58_01740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW58_01745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW58_01750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW58_01755	COG0138	bifunctional purine biosynthesis protein purh
EXW58_01760	COG0151	Belongs to the GarS family
EXW58_01780	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW58_01785	COG0210	DNA helicase
EXW58_01790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW58_01795	COG4851	CamS sex pheromone cAM373 precursor
EXW58_01805	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_01810	COG1335	isochorismatase
EXW58_01820	COG2011	ABC-type metal ion transport system permease component
EXW58_01825	COG1464	Belongs to the NlpA lipoprotein family
EXW58_01835	COG0003	Pfam Anion-transporting ATPase
EXW58_01840	COG1846	Transcriptional regulator
EXW58_01845	COG4682	membrane
EXW58_01855	COG0154	amidase activity
EXW58_01860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW58_01865	COG1597	lipid kinase activity
EXW58_01875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW58_01885	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_01890	COG2076	Multidrug Resistance protein
EXW58_01900	COG2309	aminopeptidase activity
EXW58_01915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_01925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW58_01930	COG5002	protein histidine kinase activity
EXW58_01945	COG4807	Protein conserved in bacteria
EXW58_01970	COG1757	Na H antiporter
EXW58_01975	COG1473	amidohydrolase
EXW58_01995	COG0450	alkyl hydroperoxide reductase
EXW58_02005	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW58_02015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_02020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_02025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_02035	COG0492	ferredoxin-NADP+ reductase activity
EXW58_02050	COG0166	Belongs to the GPI family
EXW58_02075	COG5002	protein histidine kinase activity
EXW58_02090	COG3541	Predicted nucleotidyltransferase
EXW58_02095	COG0723	plastoquinol--plastocyanin reductase activity
EXW58_02095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW58_02105	COG0765	amino acid transport
EXW58_02110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_02115	COG1126	abc transporter atp-binding protein
EXW58_02120	COG0840	transmembrane signaling receptor activity
EXW58_02125	COG0277	FAD linked oxidase domain protein
EXW58_02130	COG0366	Alpha amylase catalytic
EXW58_02135	COG1263	PTS System
EXW58_02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_02135	COG2190	(PTS) system
EXW58_02160	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW58_02165	COG0352	thiamine-phosphate diphosphorylase activity
EXW58_02170	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW58_02190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW58_02200	COG1116	anion transmembrane transporter activity
EXW58_02205	COG0488	(ABC) transporter
EXW58_02230	COG2270	Major facilitator Superfamily
EXW58_02260	COG2310	stress, protein
EXW58_02265	COG2310	stress, protein
EXW58_02270	COG2310	stress, protein
EXW58_02275	COG0861	Integral membrane protein TerC family
EXW58_02285	COG3853	Toxic anion resistance protein (TelA)
EXW58_02295	COG4840	Belongs to the UPF0435 family
EXW58_02300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW58_02310	COG1295	ribonuclease BN
EXW58_02315	COG2217	Heavy metal translocating P-type atpase
EXW58_02320	COG0697	spore germination
EXW58_02350	COG0586	Pfam SNARE associated Golgi protein
EXW58_02365	COG3871	stress protein (general stress protein 26)
EXW58_02370	COG0387	Pfam Sodium calcium exchanger
EXW58_02380	COG0535	radical SAM domain protein
EXW58_02400	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW58_02405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EXW58_02425	COG3829	transcription factor binding
EXW58_02435	COG0833	amino acid
EXW58_02440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW58_02465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_02465	COG1263	PTS System
EXW58_02470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW58_02490	COG1215	transferase activity, transferring glycosyl groups
EXW58_02500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW58_02500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW58_02520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW58_02525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW58_02540	COG1228	amidohydrolase
EXW58_02545	COG1090	epimerase
EXW58_02550	COG2137	regulation of response to DNA damage stimulus
EXW58_02575	COG1988	membrane-bound metal-dependent
EXW58_02580	COG1194	a g-specific adenine glycosylase
EXW58_02595	COG3557	Belongs to the UPF0374 family
EXW58_02600	COG1132	(ABC) transporter
EXW58_02605	COG4129	membrane
EXW58_02615	COG0067	glutamate synthase
EXW58_02615	COG0069	glutamate synthase activity
EXW58_02615	COG0070	glutamate synthase
EXW58_02620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW58_02625	COG4555	ABC transporter
EXW58_02645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW58_02650	COG0735	belongs to the Fur family
EXW58_02765	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW58_02770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW58_02790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW58_02800	COG2766	serine protein kinase
EXW58_02805	COG2718	Belongs to the UPF0229 family
EXW58_02820	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW58_02825	COG2268	Band 7 protein
EXW58_02830	COG3290	protein histidine kinase activity
EXW58_02835	COG4565	transcriptional regulatory protein
EXW58_02845	COG2851	Citrate transporter
EXW58_02865	COG0745	RESPONSE REGULATOR receiver
EXW58_02870	COG5002	protein histidine kinase activity
EXW58_02880	COG4990	cell redox homeostasis
EXW58_02890	COG3290	protein histidine kinase activity
EXW58_02895	COG4565	transcriptional regulatory protein
EXW58_02900	COG3493	citrate carrier protein
EXW58_02905	COG0281	malic enzyme
EXW58_02915	COG0697	spore germination
EXW58_02920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_02930	COG5002	protein histidine kinase activity
EXW58_02935	COG0745	RESPONSE REGULATOR receiver
EXW58_02940	COG0456	acetyltransferase
EXW58_02945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW58_02950	COG3383	formate dehydrogenase (NAD+) activity
EXW58_02955	COG2427	Protein of unknown function (DUF1641)
EXW58_02970	COG0531	amino acid
EXW58_02980	COG0640	Transcriptional regulator
EXW58_02985	COG2217	Heavy metal translocating P-type atpase
EXW58_02990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW58_03000	COG3227	Zinc metalloprotease (Elastase)
EXW58_03020	COG2720	vancomycin resistance protein
EXW58_03025	COG1316	TRANSCRIPTIONal
EXW58_03030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_03035	COG0346	lactoylglutathione lyase activity
EXW58_03040	COG1253	flavin adenine dinucleotide binding
EXW58_03045	COG1027	Aspartate ammonia-lyase
EXW58_03050	COG1620	l-lactate permease
EXW58_03055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_03075	COG3104	oligopeptide transport
EXW58_03080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_03085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_03090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_03105	COG0156	8-amino-7-oxononanoate synthase activity
EXW58_03110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW58_03120	COG2801	Transposase and inactivated derivatives
EXW58_03130	COG4548	von Willebrand factor, type A
EXW58_03135	COG0714	Associated with various cellular activities
EXW58_03160	COG0531	amino acid
EXW58_03165	COG2188	Transcriptional regulator
EXW58_03170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_03170	COG1263	PTS System
EXW58_03175	COG0366	Alpha amylase catalytic
EXW58_03195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW58_03200	COG1115	amino acid carrier protein
EXW58_03205	COG1126	abc transporter atp-binding protein
EXW58_03210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_03215	COG0765	amino acid transport
EXW58_03220	COG0765	amino acid transport
EXW58_03225	COG0833	amino acid
EXW58_03240	COG2378	regulation of single-species biofilm formation
EXW58_03245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW58_03250	COG5002	protein histidine kinase activity
EXW58_03265	COG0659	secondary active sulfate transmembrane transporter activity
EXW58_03290	COG0601	transmembrane transport
EXW58_03295	COG4608	Belongs to the ABC transporter superfamily
EXW58_03305	COG2271	Major facilitator Superfamily
EXW58_03310	COG1846	Transcriptional regulator
EXW58_03315	COG0477	Major facilitator Superfamily
EXW58_03320	COG1609	Transcriptional regulator
EXW58_03325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW58_03330	COG1869	D-ribose catabolic process
EXW58_03340	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW58_03345	COG1879	ABC-type sugar transport system periplasmic component
EXW58_03375	COG1063	alcohol dehydrogenase
EXW58_03420	COG0840	transmembrane signaling receptor activity
EXW58_03425	COG1388	LysM domain
EXW58_03425	COG3584	3D domain protein
EXW58_03430	COG1476	TRANSCRIPTIONal
EXW58_03450	COG3104	oligopeptide transport
EXW58_03455	COG1114	Component of the transport system for branched-chain amino acids
EXW58_03470	COG1113	amino acid transport
EXW58_03475	COG2252	PERMEase
EXW58_03490	COG2153	protein acetylation
EXW58_03500	COG0569	domain protein
EXW58_03500	COG0475	glutathione-regulated potassium exporter activity
EXW58_03510	COG1845	cytochrome c oxidase, subunit III
EXW58_03515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW58_03520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EXW58_03525	COG0833	amino acid
EXW58_03530	COG4990	cell redox homeostasis
EXW58_03545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW58_03550	COG0697	spore germination
EXW58_03555	COG0531	amino acid
EXW58_03565	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW58_03570	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW58_03580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW58_03585	COG0573	inorganic phosphate transmembrane transporter activity
EXW58_03590	COG0581	inorganic phosphate transmembrane transporter activity
EXW58_03600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW58_03645	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW58_03725	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW58_03740	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW58_03740	COG4991	sh3 domain protein
EXW58_03740	COG3103	Sh3 type 3 domain protein
EXW58_03745	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW58_03750	COG1116	anion transmembrane transporter activity
EXW58_03755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW58_03760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW58_03765	COG0352	thiamine-phosphate diphosphorylase activity
EXW58_03770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW58_03775	COG2104	thiamine diphosphate biosynthetic process
EXW58_03780	COG2022	thiamine diphosphate biosynthetic process
EXW58_03785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW58_03790	COG0351	phosphomethylpyrimidine kinase
EXW58_03820	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW58_03825	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW58_03830	COG2205	protein histidine kinase activity
EXW58_03855	COG1136	(ABC) transporter
EXW58_03865	COG2252	PERMEase
EXW58_03870	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_03930	COG0778	Nitroreductase
EXW58_03935	COG2719	SpoVR family
EXW58_03955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW58_03965	COG1937	Protein conserved in bacteria
EXW58_03970	COG0425	Belongs to the sulfur carrier protein TusA family
EXW58_03970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW58_03975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW58_03975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_03980	COG0425	Belongs to the sulfur carrier protein TusA family
EXW58_03985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW58_03990	COG2210	Belongs to the sulfur carrier protein TusA family
EXW58_03995	COG0730	response to heat
EXW58_04010	COG1316	TRANSCRIPTIONal
EXW58_04015	COG0604	alcohol dehydrogenase
EXW58_04020	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW58_04030	COG2814	Major facilitator Superfamily
EXW58_04045	COG3711	transcriptional antiterminator
EXW58_04045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW58_04050	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW58_04055	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW58_04085	COG1388	LysM domain
EXW58_04085	COG3584	3D domain protein
EXW58_04090	COG0577	efflux transmembrane transporter activity
EXW58_04095	COG1136	(ABC) transporter
EXW58_04110	COG1114	Component of the transport system for branched-chain amino acids
EXW58_04115	COG3546	catalase activity
EXW58_04145	COG0586	Pfam SNARE associated Golgi protein
EXW58_04180	COG0531	amino acid
EXW58_04185	COG0475	glutathione-regulated potassium exporter activity
EXW58_04195	COG1737	Transcriptional regulator
EXW58_04205	COG1263	PTS System
EXW58_04205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_04215	COG2259	Doxx family
EXW58_04240	COG1522	sequence-specific DNA binding
EXW58_04265	COG2076	Multidrug Resistance protein
EXW58_04270	COG1309	transcriptional regulator
EXW58_04280	COG2814	Major facilitator Superfamily
EXW58_04285	COG1733	regulation of RNA biosynthetic process
EXW58_04320	COG4473	ABC transporter
EXW58_04335	COG0531	amino acid
EXW58_04340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EXW58_04345	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_04360	COG1132	(ABC) transporter
EXW58_04365	COG1132	(ABC) transporter
EXW58_04370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_04375	COG0765	amino acid transport
EXW58_04380	COG1126	abc transporter atp-binding protein
EXW58_04395	COG0189	ligase activity
EXW58_04405	COG4399	Belongs to the UPF0754 family
EXW58_04410	COG3679	Belongs to the UPF0342 family
EXW58_04415	COG0463	Glycosyl transferase, family 2
EXW58_04420	COG1216	Glycosyl transferase, family 2
EXW58_04425	COG2094	Belongs to the DNA glycosylase MPG family
EXW58_04430	COG0561	phosphatase activity
EXW58_04435	COG3409	Peptidoglycan-binding domain 1 protein
EXW58_04435	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW58_04440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW58_04445	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_04460	COG0586	Pfam SNARE associated Golgi protein
EXW58_04470	COG4978	Transcriptional regulator
EXW58_04470	COG0789	Transcriptional regulator
EXW58_04480	COG0659	secondary active sulfate transmembrane transporter activity
EXW58_04485	COG2244	polysaccharide biosynthetic process
EXW58_04505	COG1024	Enoyl-CoA hydratase
EXW58_04520	COG1363	Peptidase, m42
EXW58_04535	COG2801	Transposase and inactivated derivatives
EXW58_04550	COG2318	DinB family
EXW58_04560	COG1113	amino acid transport
EXW58_04565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW58_04585	COG0579	oxidoreductase
EXW58_04590	COG2226	methyltransferase
EXW58_04595	COG3290	protein histidine kinase activity
EXW58_04595	COG3829	transcription factor binding
EXW58_04605	COG1301	dicarboxylic acid transport
EXW58_04655	COG0477	Major facilitator Superfamily
EXW58_04660	COG3290	protein histidine kinase activity
EXW58_04665	COG4565	transcriptional regulatory protein
EXW58_04670	COG3181	Tripartite tricarboxylate transporter family receptor
EXW58_04700	COG0433	COG0433 Predicted ATPase
EXW58_04725	COG1074	ATP-dependent DNA helicase activity
EXW58_04735	COG1104	cysteine desulfurase activity
EXW58_04770	COG0305	Participates in initiation and elongation during chromosome replication
EXW58_04795	COG1842	Phage shock protein A
EXW58_04805	COG0477	Major facilitator Superfamily
EXW58_04850	COG2814	Major facilitator Superfamily
EXW58_04855	COG0640	Transcriptional regulator
EXW58_04880	COG2376	Dihydroxyacetone kinase
EXW58_04895	COG2376	Dihydroxyacetone kinase
EXW58_04915	COG2720	vancomycin resistance protein
EXW58_04925	COG1335	isochorismatase
EXW58_04935	COG2373	Large extracellular alpha-helical protein
EXW58_04970	COG0076	glutamate decarboxylase activity
EXW58_04990	COG2807	transmembrane transport
EXW58_04995	COG2186	Transcriptional regulator
EXW58_05015	COG4585	Histidine kinase
EXW58_05020	COG2197	response regulator
EXW58_05045	COG0420	3'-5' exonuclease activity
EXW58_05050	COG4717	serine-type aminopeptidase activity
EXW58_05055	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW58_05065	COG1733	regulation of RNA biosynthetic process
EXW58_05070	COG0778	Nitroreductase
EXW58_05100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW58_05110	COG0346	lactoylglutathione lyase activity
EXW58_05115	COG0346	lactoylglutathione lyase activity
EXW58_05120	COG2267	carboxylic ester hydrolase activity
EXW58_05130	COG2140	Oxalate decarboxylase
EXW58_05135	COG3620	sequence-specific DNA binding
EXW58_05140	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW58_05145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW58_05150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW58_05155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW58_05160	COG1595	DNA-templated transcription, initiation
EXW58_05175	COG1309	transcriptional regulator
EXW58_05180	COG2814	Major facilitator Superfamily
EXW58_05185	COG3973	AAA domain
EXW58_05215	COG0537	adenosine 5'-monophosphoramidase activity
EXW58_05220	COG1131	(ABC) transporter
EXW58_05225	COG4473	ABC transporter
EXW58_05275	COG0247	lactate metabolic process
EXW58_05280	COG1139	Iron-sulfur cluster binding protein
EXW58_05285	COG1556	Lactate utilization protein
EXW58_05315	COG1309	transcriptional regulator
EXW58_05320	COG3402	PFAM membrane-flanked domain
EXW58_05325	COG3428	Bacterial PH domain
EXW58_05350	COG3402	PFAM membrane-flanked domain
EXW58_05355	COG3428	Bacterial PH domain
EXW58_05360	COG2329	Antibiotic biosynthesis monooxygenase
EXW58_05365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW58_05375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW58_05380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW58_05400	COG1309	transcriptional regulator
EXW58_05405	COG1511	domain protein
EXW58_05410	COG0438	transferase activity, transferring glycosyl groups
EXW58_05410	COG1216	Glycosyl transferase, family 2
EXW58_05435	COG2378	regulation of single-species biofilm formation
EXW58_05440	COG1609	Transcriptional regulator
EXW58_05450	COG1234	tRNA 3'-trailer cleavage
EXW58_05455	COG0095	Lipoate-protein ligase
EXW58_05465	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_05475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW58_05480	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EXW58_05485	COG4208	sulfate ABC transporter
EXW58_05500	COG1408	metallophosphoesterase
EXW58_05505	COG1078	dGTPase activity
EXW58_05515	COG2801	Transposase and inactivated derivatives
EXW58_05530	COG1595	DNA-templated transcription, initiation
EXW58_05540	COG2207	Transcriptional regulator
EXW58_05540	COG3708	Transcriptional regulator
EXW58_05550	COG2205	protein histidine kinase activity
EXW58_05555	COG0745	RESPONSE REGULATOR receiver
EXW58_05570	COG0501	Belongs to the peptidase M48B family
EXW58_05575	COG0697	spore germination
EXW58_05590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW58_05595	COG2224	Isocitrate lyase
EXW58_05605	COG1278	Cold shock
EXW58_05610	COG1216	Glycosyl transferase, family 2
EXW58_05625	COG4903	ComK protein
EXW58_05635	COG0398	Pfam SNARE associated Golgi protein
EXW58_05645	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW58_05650	COG1074	ATP-dependent DNA helicase activity
EXW58_05700	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW58_05725	COG0367	asparagine synthase
EXW58_05735	COG0753	catalase activity
EXW58_05740	COG0004	ammonium transporteR
EXW58_05755	COG1666	GTP binding
EXW58_05760	COG2996	Protein conserved in bacteria
EXW58_05765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW58_05775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_05790	COG0561	phosphatase activity
EXW58_05810	COG2267	carboxylic ester hydrolase activity
EXW58_05825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW58_05830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW58_05835	COG5504	Zn-dependent protease
EXW58_05850	COG0180	Tryptophanyl-tRNA synthetase
EXW58_05865	COG4166	transmembrane transport
EXW58_05870	COG0601	transmembrane transport
EXW58_05875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW58_05880	COG0444	Belongs to the ABC transporter superfamily
EXW58_05885	COG4608	Belongs to the ABC transporter superfamily
EXW58_05890	COG0534	Mate efflux family protein
EXW58_05895	COG4166	transmembrane transport
EXW58_05915	COG0861	Integral membrane protein TerC family
EXW58_05920	COG4862	establishment of competence for transformation
EXW58_05925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW58_05935	COG1164	Oligoendopeptidase f
EXW58_05945	COG2346	COG2346, Truncated hemoglobins
EXW58_05950	COG4116	CYTH
EXW58_05960	COG2357	RelA SpoT domain protein
EXW58_05970	COG0564	pseudouridine synthase activity
EXW58_05980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW58_05985	COG0772	Belongs to the SEDS family
EXW58_05995	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW58_06010	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW58_06055	COG2153	protein acetylation
EXW58_06060	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW58_06065	COG2382	esterase
EXW58_06090	COG5492	domain, Protein
EXW58_06095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW58_06110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW58_06110	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW58_06115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW58_06120	COG0134	indole-3-glycerol-phosphate synthase activity
EXW58_06125	COG0135	phosphoribosylanthranilate isomerase activity
EXW58_06135	COG0159	tryptophan synthase activity
EXW58_06145	COG1620	l-lactate permease
EXW58_06150	COG5634	Uncharacterized conserved protein (DUF2278)
EXW58_06185	COG2226	methyltransferase
EXW58_06205	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW58_06210	COG0567	Dehydrogenase, E1 component
EXW58_06215	COG1476	TRANSCRIPTIONal
EXW58_06260	COG1686	Belongs to the peptidase S11 family
EXW58_06265	COG0681	Belongs to the peptidase S26 family
EXW58_06300	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_06310	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW58_06315	COG1177	transmembrane transport
EXW58_06320	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW58_06330	COG2409	Drug exporters of the RND superfamily
EXW58_06340	COG0564	pseudouridine synthase activity
EXW58_06350	COG2340	Cysteine-rich secretory protein family
EXW58_06355	COG0247	lactate metabolic process
EXW58_06360	COG0277	FAD linked oxidase domain protein
EXW58_06365	COG3835	regulator
EXW58_06375	COG0745	RESPONSE REGULATOR receiver
EXW58_06380	COG5002	protein histidine kinase activity
EXW58_06380	COG3850	Histidine kinase
EXW58_06385	COG2186	Transcriptional regulator
EXW58_06400	COG1556	Lactate utilization protein
EXW58_06405	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW58_06420	COG2116	formate transmembrane transporter activity
EXW58_06425	COG0861	Integral membrane protein TerC family
EXW58_06430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW58_06440	COG2030	dehydratase
EXW58_06460	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_06465	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW58_06475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW58_06490	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW58_06495	COG3842	ATPase activity
EXW58_06505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW58_06510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW58_06520	COG1349	DNA-binding transcription factor activity
EXW58_06530	COG0235	Class ii aldolase
EXW58_06540	COG2861	carbohydrate metabolic process
EXW58_06550	COG3852	Histidine kinase
EXW58_06555	COG1846	Transcriptional regulator
EXW58_06565	COG2318	DinB family
EXW58_06570	COG5002	protein histidine kinase activity
EXW58_06580	COG0720	synthase
EXW58_06590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW58_06595	COG4873	Protein conserved in bacteria
EXW58_06605	COG0456	acetyltransferase
EXW58_06625	COG1780	Probably involved in ribonucleotide reductase function
EXW58_06640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW58_06645	COG0531	amino acid
EXW58_06660	COG2204	response regulator
EXW58_06665	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_06675	COG1725	Transcriptional regulator
EXW58_06680	COG1131	(ABC) transporter
EXW58_06690	COG1131	(ABC) transporter
EXW58_06695	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW58_06700	COG1266	CAAX protease self-immunity
EXW58_06710	COG1522	sequence-specific DNA binding
EXW58_06720	COG1335	isochorismatase
EXW58_06730	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW58_06735	COG2070	2-Nitropropane dioxygenase
EXW58_06740	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW58_06745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW58_06750	COG1696	Membrane protein involved in D-alanine export
EXW58_06770	COG0716	FMN binding
EXW58_06780	COG3173	Aminoglycoside phosphotransferase
EXW58_06795	COG0534	Mate efflux family protein
EXW58_06815	COG1846	Transcriptional regulator
EXW58_06830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW58_06840	COG3874	Sporulation protein YtfJ
EXW58_06860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW58_06865	COG0028	Belongs to the TPP enzyme family
EXW58_06870	COG0440	acetolactate synthase activity
EXW58_06880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW58_06890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW58_06900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW58_06905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW58_06915	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW58_06920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW58_06925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW58_06930	COG0107	imidazoleglycerol-phosphate synthase activity
EXW58_06940	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW58_06945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW58_06960	COG1183	phosphatidylcholine synthase activity
EXW58_06965	COG1368	sulfuric ester hydrolase activity
EXW58_06975	COG0019	diaminopimelate decarboxylase activity
EXW58_06990	COG2046	Belongs to the sulfate adenylyltransferase family
EXW58_06995	COG0529	Catalyzes the synthesis of activated sulfate
EXW58_07000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW58_07020	COG1648	precorrin-2 dehydrogenase activity
EXW58_07030	COG0733	neurotransmitter:sodium symporter activity
EXW58_07050	COG1757	Na H antiporter
EXW58_07060	COG3344	reverse transcriptase
EXW58_07075	COG4758	membrane
EXW58_07080	COG4585	Histidine kinase
EXW58_07085	COG2197	response regulator
EXW58_07095	COG1114	Component of the transport system for branched-chain amino acids
EXW58_07150	COG0730	response to heat
EXW58_07155	COG0306	phosphate transporter
EXW58_07160	COG1392	Phosphate transport regulator
EXW58_07165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW58_07180	COG3852	Histidine kinase
EXW58_07185	COG1801	Protein of unknown function DUF72
EXW58_07195	COG0582	viral genome integration into host DNA
EXW58_07200	COG5002	protein histidine kinase activity
EXW58_07215	COG0392	lysyltransferase activity
EXW58_07215	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW58_07230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW58_07235	COG1686	Belongs to the peptidase S11 family
EXW58_07240	COG2715	membrane protein required for spore maturation
EXW58_07245	COG0700	Nucleoside recognition
EXW58_07250	COG1187	pseudouridine synthase activity
EXW58_07260	COG1333	cytochrome c biogenesis protein
EXW58_07265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW58_07270	COG0745	RESPONSE REGULATOR receiver
EXW58_07275	COG5002	protein histidine kinase activity
EXW58_07280	COG2096	Adenosyltransferase
EXW58_07285	COG4942	peptidase
EXW58_07295	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW58_07300	COG1141	Ferredoxin
EXW58_07310	COG4955	Helix-turn-helix domain
EXW58_07315	COG0514	ATP-dependent DNA helicase (RecQ)
EXW58_07320	COG1266	CAAX protease self-immunity
EXW58_07330	COG1408	metallophosphoesterase
EXW58_07345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW58_07360	COG0492	ferredoxin-NADP+ reductase activity
EXW58_07365	COG0252	asparaginase activity
EXW58_07375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW58_07385	COG1304	FMN binding
EXW58_07420	COG1160	GTP binding
EXW58_07445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW58_07460	COG0142	geranyltranstransferase activity
EXW58_07465	COG2226	methyltransferase
EXW58_07470	COG0142	geranyltranstransferase activity
EXW58_07485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW58_07495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW58_07500	COG0457	Tetratricopeptide repeat
EXW58_07505	COG5582	Belongs to the UPF0302 family
EXW58_07520	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW58_07525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW58_07525	COG2010	Cytochrome c
EXW58_07535	COG3344	reverse transcriptase
EXW58_07540	COG4347	Protein of unknown function (DUF1405)
EXW58_07555	COG2738	Putative neutral zinc metallopeptidase
EXW58_07565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_07570	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW58_07575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW58_07580	COG1803	Methylglyoxal synthase
EXW58_07585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW58_07590	COG0438	transferase activity, transferring glycosyl groups
EXW58_07595	COG0617	tRNA 3'-terminal CCA addition
EXW58_07605	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW58_07610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW58_07620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW58_07620	COG1199	ATP-dependent helicase activity
EXW58_07640	COG3935	DnaD domain protein
EXW58_07645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW58_07655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW58_07655	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW58_07660	COG3331	DNA recombination
EXW58_07695	COG4474	Belongs to the UPF0398 family
EXW58_07700	COG3599	regulation of cell shape
EXW58_07710	COG0116	Belongs to the methyltransferase superfamily
EXW58_07720	COG1199	ATP-dependent helicase activity
EXW58_07725	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW58_07735	COG0024	Methionine aminopeptidase
EXW58_07745	COG2233	PERMEase
EXW58_07750	COG2311	Membrane
EXW58_07755	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW58_07765	COG0456	acetyltransferase
EXW58_07775	COG2897	thiosulfate sulfurtransferase activity
EXW58_07815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW58_07855	COG0328	RNA-DNA hybrid ribonuclease activity
EXW58_07890	COG3403	YqcI/YcgG family
EXW58_07895	COG1280	lysine exporter protein (LysE YggA)
EXW58_07910	COG3162	membrane
EXW58_07915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW58_07920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW58_07930	COG0475	glutathione-regulated potassium exporter activity
EXW58_07935	COG4978	Transcriptional regulator
EXW58_07935	COG0789	Transcriptional regulator
EXW58_07945	COG2323	membrane
EXW58_07950	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW58_07995	COG1923	regulation of RNA biosynthetic process
EXW58_08015	COG0861	Integral membrane protein TerC family
EXW58_08025	COG3383	formate dehydrogenase (NAD+) activity
EXW58_08030	COG2427	Protein of unknown function (DUF1641)
EXW58_08035	COG5609	conserved protein (DUF2294)
EXW58_08040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW58_08050	COG2116	formate transmembrane transporter activity
EXW58_08055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW58_08060	COG0303	'Molybdopterin
EXW58_08065	COG0314	molybdopterin synthase activity
EXW58_08080	COG0489	protein tyrosine kinase activity
EXW58_08090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW58_08095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW58_08105	COG1419	protein localization to endoplasmic reticulum
EXW58_08115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW58_08145	COG0412	Dienelactone hydrolase
EXW58_08150	COG2329	Antibiotic biosynthesis monooxygenase
EXW58_08165	COG3764	Sortase (surface protein transpeptidase)
EXW58_08180	COG2801	Transposase and inactivated derivatives
EXW58_08210	COG0583	DNA-binding transcription factor activity
EXW58_08215	COG3842	ATPase activity
EXW58_08255	COG1686	Belongs to the peptidase S11 family
EXW58_08280	COG1846	Transcriptional regulator
EXW58_08290	COG0367	asparagine synthase
EXW58_08320	COG1757	Na H antiporter
EXW58_08330	COG0277	FAD linked oxidase domain protein
EXW58_08345	COG0534	Mate efflux family protein
EXW58_08350	COG3340	Belongs to the peptidase S51 family
EXW58_08370	COG0785	Cytochrome C biogenesis protein
EXW58_08375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_08390	COG3048	D-serine ammonia-lyase activity
EXW58_08395	COG2733	membrane
EXW58_08440	COG1131	(ABC) transporter
EXW58_08460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW58_08465	COG0528	UMP kinase activity
EXW58_08475	COG1027	Aspartate ammonia-lyase
EXW58_08480	COG0281	malic enzyme
EXW58_08485	COG4191	Histidine kinase
EXW58_08490	COG0784	Response regulator, receiver
EXW58_08495	COG1846	Transcriptional regulator
EXW58_08505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW58_08520	COG2502	aspartate--ammonia ligase
EXW58_08560	COG2814	Major facilitator Superfamily
EXW58_08580	COG1595	DNA-templated transcription, initiation
EXW58_08595	COG1695	Transcriptional regulator
EXW58_08610	COG0477	Major facilitator Superfamily
EXW58_08615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW58_08625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW58_08630	COG2223	nitrite transmembrane transporter activity
EXW58_08635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW58_08650	COG2244	polysaccharide biosynthetic process
EXW58_08655	COG0733	neurotransmitter:sodium symporter activity
EXW58_08665	COG5566	PFAM Mor transcription activator
EXW58_08670	COG2323	membrane
EXW58_08685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW58_08700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW58_08725	COG2814	Major facilitator Superfamily
EXW58_08730	COG3384	dioxygenase
EXW58_08765	COG4166	transmembrane transport
EXW58_08775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_08785	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW58_08790	COG1054	Belongs to the UPF0176 family
EXW58_08800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW58_08805	COG0531	amino acid
EXW58_08825	COG1280	lysine exporter protein (LysE YggA)
EXW58_08840	COG2390	Transcriptional regulator
EXW58_08845	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW58_08850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_08855	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW58_08870	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW58_08885	COG2267	carboxylic ester hydrolase activity
EXW58_08890	COG0583	DNA-binding transcription factor activity
EXW58_08910	COG0006	proline dipeptidase activity
EXW58_08915	COG2132	Multicopper oxidase
EXW58_08930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW58_08950	COG1114	Component of the transport system for branched-chain amino acids
EXW58_08960	COG1276	copper resistance
EXW58_08960	COG2372	response to copper ion
EXW58_08965	COG4549	nuclear export factor GLE1
EXW58_08970	COG0697	spore germination
EXW58_08975	COG0583	DNA-binding transcription factor activity
EXW58_08985	COG1959	2 iron, 2 sulfur cluster binding
EXW58_08990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW58_09005	COG0628	permease
EXW58_09020	COG1231	oxidoreductase activity
EXW58_09025	COG0523	cobalamin synthesis protein
EXW58_09040	COG2030	dehydratase
EXW58_09045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW58_09060	COG0411	ABC transporter
EXW58_09080	COG0583	DNA-binding transcription factor activity
EXW58_09090	COG1942	4-Oxalocrotonate Tautomerase
EXW58_09105	COG0346	lactoylglutathione lyase activity
EXW58_09115	COG1271	oxidase subunit
EXW58_09120	COG1294	oxidase, subunit
EXW58_09125	COG4988	ABC transporter
EXW58_09130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW58_09160	COG1686	Belongs to the peptidase S11 family
EXW58_09170	COG0791	NLP P60 protein
EXW58_09170	COG1388	LysM domain
EXW58_09180	COG1132	(ABC) transporter
EXW58_09185	COG0745	RESPONSE REGULATOR receiver
EXW58_09190	COG5002	protein histidine kinase activity
EXW58_09195	COG0300	oxidoreductase activity
EXW58_09200	COG4122	O-methyltransferase activity
EXW58_09230	COG0460	homoserine dehydrogenase
EXW58_09240	COG0083	homoserine kinase activity
EXW58_09255	COG1316	TRANSCRIPTIONal
EXW58_09270	COG1285	pathogenesis
EXW58_09275	COG1247	-acetyltransferase
EXW58_09295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW58_09305	COG1082	Xylose isomerase domain protein TIM barrel
EXW58_09315	COG2814	Major facilitator Superfamily
EXW58_09320	COG1279	arginine transmembrane transporter activity
EXW58_09325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_09330	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW58_09365	COG0577	efflux transmembrane transporter activity
EXW58_09370	COG2002	toxin-antitoxin pair type II binding
EXW58_09375	COG1404	Belongs to the peptidase S8 family
EXW58_09405	COG0840	transmembrane signaling receptor activity
EXW58_09440	COG3949	Membrane
EXW58_09445	COG0783	Belongs to the Dps family
EXW58_09460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW58_09470	COG1231	oxidoreductase activity
EXW58_09475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_09480	COG4989	oxidoreductase activity
EXW58_09485	COG0523	cobalamin synthesis protein
EXW58_09490	COG0456	acetyltransferase
EXW58_09495	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW58_09500	COG0702	epimerase
EXW58_09550	COG3331	DNA recombination
EXW58_09660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW58_09670	COG4166	transmembrane transport
EXW58_09685	COG0406	alpha-ribazole phosphatase activity
EXW58_09695	COG5337	Spore coat protein CotH
EXW58_09700	COG1051	belongs to the nudix hydrolase family
EXW58_09705	COG0586	Pfam SNARE associated Golgi protein
EXW58_09710	COG2244	polysaccharide biosynthetic process
EXW58_09720	COG0701	Predicted permease
EXW58_09725	COG3689	TIGRFAM TIGR03943 family protein
EXW58_09730	COG1607	acyl-coa hydrolase
EXW58_09740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW58_09755	COG0702	epimerase
EXW58_09760	COG2839	Protein conserved in bacteria
EXW58_09765	COG1253	flavin adenine dinucleotide binding
EXW58_09780	COG1114	Component of the transport system for branched-chain amino acids
EXW58_09785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW58_09805	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW58_09815	COG1876	peptidase activity
EXW58_09845	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW58_09850	COG2368	4-hydroxyphenylacetate
EXW58_09875	COG0251	oxidation-reduction process
EXW58_09885	COG3971	2-oxopent-4-enoate hydratase activity
EXW58_09905	COG1942	4-Oxalocrotonate Tautomerase
EXW58_09915	COG0561	phosphatase activity
EXW58_09920	COG1846	Transcriptional regulator
EXW58_09925	COG2814	Major facilitator Superfamily
EXW58_09935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW58_09950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_09955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_09980	COG0456	acetyltransferase
EXW58_10020	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW58_10100	COG3874	Sporulation protein YtfJ
EXW58_10125	COG2226	methyltransferase
EXW58_10145	COG0346	lactoylglutathione lyase activity
EXW58_10155	COG0604	alcohol dehydrogenase
EXW58_10160	COG1595	DNA-templated transcription, initiation
EXW58_10175	COG2801	Transposase and inactivated derivatives
EXW58_10195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW58_10195	COG0426	domain, Protein
EXW58_10205	COG0386	Belongs to the glutathione peroxidase family
EXW58_10210	COG1305	Transglutaminase-like
EXW58_10215	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW58_10220	COG0714	Associated with various cellular activities
EXW58_10235	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW58_10240	COG1140	nitrate reductase beta subunit
EXW58_10245	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW58_10250	COG2181	nitrate reductase activity
EXW58_10255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW58_10260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW58_10265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW58_10270	COG0303	'Molybdopterin
EXW58_10275	COG0314	molybdopterin synthase activity
EXW58_10285	COG2223	nitrite transmembrane transporter activity
EXW58_10290	COG1648	precorrin-2 dehydrogenase activity
EXW58_10300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW58_10300	COG1587	Uroporphyrinogen-III synthase
EXW58_10305	COG2146	nitrite reductase [NAD(P)H] activity
EXW58_10310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW58_10320	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW58_10350	COG2359	stage V sporulation protein S
EXW58_10375	COG4824	toxin secretion phage lysis holin
EXW58_10385	COG5444	nuclease activity
EXW58_10410	COG1418	mRNA catabolic process
EXW58_10415	COG0488	(ABC) transporter
EXW58_10435	COG1413	lyase activity
EXW58_10450	COG2521	methyltransferase
EXW58_10450	COG2136	Putative SAM-dependent methyltransferase
EXW58_10455	COG0018	arginyl-trna synthetase
EXW58_10510	COG0017	Asparaginyl-tRNA synthetase
EXW58_10515	COG0733	neurotransmitter:sodium symporter activity
EXW58_10520	COG2267	carboxylic ester hydrolase activity
EXW58_10545	COG2610	gluconate transmembrane transporter activity
EXW58_10550	COG1454	alcohol dehydrogenase
EXW58_10565	COG0456	acetyltransferase
EXW58_10570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW58_10580	COG1131	(ABC) transporter
EXW58_10585	COG4473	ABC transporter
EXW58_10620	COG0671	phosphoesterase, PA-phosphatase related
EXW58_10640	COG0768	penicillin binding
EXW58_10655	COG1272	protein, Hemolysin III
EXW58_10660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW58_10665	COG0805	protein transport
EXW58_10675	COG1307	EDD domain protein, DegV family
EXW58_10680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW58_10685	COG1999	signal sequence binding
EXW58_10690	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW58_10695	COG0367	asparagine synthase
EXW58_10710	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW58_10715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_10720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW58_10735	COG1335	isochorismatase
EXW58_10740	COG1051	belongs to the nudix hydrolase family
EXW58_10745	COG0668	transmembrane transport
EXW58_10750	COG4585	Histidine kinase
EXW58_10750	COG2203	Gaf domain
EXW58_10755	COG2197	response regulator
EXW58_10760	COG1737	Transcriptional regulator
EXW58_10770	COG4974	Belongs to the 'phage' integrase family
EXW58_10780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EXW58_10785	COG1064	alcohol dehydrogenase
EXW58_10800	COG1070	Carbohydrate kinase
EXW58_10810	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW58_10830	COG0517	IMP dehydrogenase activity
EXW58_10830	COG1125	glycine betaine transport
EXW58_10835	COG1174	glycine betaine transport
EXW58_10870	COG1253	flavin adenine dinucleotide binding
EXW58_10875	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_10885	COG5506	Protein of unknown function (DUF1694)
EXW58_10900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW58_10905	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW58_10910	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW58_10915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW58_10920	COG0456	acetyltransferase
EXW58_10925	COG3829	transcription factor binding
EXW58_10930	COG1509	lysine 2,3-aminomutase activity
EXW58_10940	COG4479	Belongs to the UPF0346 family
EXW58_10965	COG3064	Membrane
EXW58_10965	COG0515	serine threonine protein kinase
EXW58_10965	COG4991	sh3 domain protein
EXW58_10975	COG0671	phosphoesterase, PA-phosphatase related
EXW58_10980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW58_10985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_11040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW58_11065	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_11085	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW58_11085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW58_11095	COG2814	Major facilitator Superfamily
EXW58_11100	COG0372	Belongs to the citrate synthase family
EXW58_11105	COG2079	MmgE PrpD family protein
EXW58_11110	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW58_11115	COG1960	acyl-CoA dehydrogenase activity
EXW58_11120	COG2084	Dehydrogenase
EXW58_11125	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_11130	COG1280	lysine exporter protein (LysE YggA)
EXW58_11135	COG1024	Enoyl-CoA hydratase
EXW58_11150	COG0420	3'-5' exonuclease activity
EXW58_11155	COG0419	ATPase involved in DNA repair
EXW58_11170	COG2223	nitrite transmembrane transporter activity
EXW58_11175	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_11180	COG1169	isochorismate synthase
EXW58_11185	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW58_11190	COG3433	isochorismatase activity
EXW58_11190	COG1535	isochorismatase
EXW58_11195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW58_11200	COG3251	PFAM MbtH domain protein
EXW58_11205	COG2814	Major facilitator Superfamily
EXW58_11220	COG0776	regulation of translation
EXW58_11230	COG1115	amino acid carrier protein
EXW58_11235	COG2329	Antibiotic biosynthesis monooxygenase
EXW58_11250	COG1187	pseudouridine synthase activity
EXW58_11255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW58_11280	COG1136	(ABC) transporter
EXW58_11300	COG0028	Belongs to the TPP enzyme family
EXW58_11310	COG4974	Belongs to the 'phage' integrase family
EXW58_11330	COG1253	flavin adenine dinucleotide binding
EXW58_11340	COG3344	reverse transcriptase
EXW58_11370	COG2267	carboxylic ester hydrolase activity
EXW58_11390	COG1846	Transcriptional regulator
EXW58_11400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_11405	COG1309	transcriptional regulator
EXW58_11415	COG0697	spore germination
EXW58_11420	COG0531	amino acid
EXW58_11435	COG1247	-acetyltransferase
EXW58_11460	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW58_11470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_11495	COG0561	phosphatase activity
EXW58_11505	COG0583	DNA-binding transcription factor activity
EXW58_11510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW58_11535	COG0583	DNA-binding transcription factor activity
EXW58_11540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW58_11545	COG2258	MOSC domain
EXW58_11560	COG1132	(ABC) transporter
EXW58_11565	COG1132	(ABC) transporter
EXW58_11595	COG1396	sequence-specific DNA binding
EXW58_11665	COG1309	transcriptional regulator
EXW58_11680	COG1136	(ABC) transporter
EXW58_11680	COG0577	efflux transmembrane transporter activity
EXW58_11685	COG3615	Tellurite resistance protein tehB
EXW58_11685	COG0500	methyltransferase
EXW58_11695	COG0693	protein deglycase activity
EXW58_11705	COG0588	phosphoglycerate mutase activity
EXW58_11720	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW58_11725	COG0110	maltose O-acetyltransferase activity
EXW58_11730	COG0745	RESPONSE REGULATOR receiver
EXW58_11735	COG2205	protein histidine kinase activity
EXW58_11740	COG1136	(ABC) transporter
EXW58_11745	COG0577	efflux transmembrane transporter activity
EXW58_11765	COG1136	(ABC) transporter
EXW58_11800	COG1686	Belongs to the peptidase S11 family
EXW58_11845	COG0768	penicillin binding
EXW58_11850	COG1595	DNA-templated transcription, initiation
EXW58_11860	COG0768	penicillin binding
EXW58_11865	COG0768	penicillin binding
EXW58_11915	COG1131	(ABC) transporter
EXW58_11925	COG1309	transcriptional regulator
EXW58_11930	COG1960	acyl-CoA dehydrogenase activity
EXW58_11935	COG0439	Biotin carboxylase
EXW58_11940	COG0511	ligase activity, forming carbon-carbon bonds
EXW58_11945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW58_11950	COG1024	Enoyl-CoA hydratase
EXW58_11955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW58_11960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW58_12010	COG0572	uridine kinase
EXW58_12020	COG1686	Belongs to the peptidase S11 family
EXW58_12045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW58_12095	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_12100	COG1733	regulation of RNA biosynthetic process
EXW58_12105	COG2226	methyltransferase
EXW58_12115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW58_12130	COG1309	transcriptional regulator
EXW58_12155	COG0697	spore germination
EXW58_12160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_12195	COG2323	membrane
EXW58_12200	COG2132	Multicopper oxidase
EXW58_12205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_12210	COG0697	spore germination
EXW58_12215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW58_12220	COG0201	protein transport
EXW58_12230	COG0737	Belongs to the 5'-nucleotidase family
EXW58_12235	COG3227	Zinc metalloprotease (Elastase)
EXW58_12240	COG1523	belongs to the glycosyl hydrolase 13 family
EXW58_12245	COG1073	alpha beta
EXW58_12255	COG0577	efflux transmembrane transporter activity
EXW58_12260	COG1136	(ABC) transporter
EXW58_12295	COG5002	protein histidine kinase activity
EXW58_12300	COG0745	RESPONSE REGULATOR receiver
EXW58_12305	COG1011	Hydrolase
EXW58_12325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW58_12330	COG1183	phosphatidylcholine synthase activity
EXW58_12335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW58_12350	COG1132	(ABC) transporter
EXW58_12365	COG3961	Belongs to the TPP enzyme family
EXW58_12385	COG0322	excinuclease ABC activity
EXW58_12410	COG2318	DinB family
EXW58_12425	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW58_12500	COG2223	nitrite transmembrane transporter activity
EXW58_12505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW58_12515	COG0494	nUDIX hydrolase
EXW58_12530	COG0697	spore germination
EXW58_12565	COG2814	Major facilitator Superfamily
EXW58_12605	COG0768	penicillin binding
EXW58_12610	COG0671	phosphoesterase, PA-phosphatase related
EXW58_12615	COG0604	alcohol dehydrogenase
EXW58_12620	COG5002	protein histidine kinase activity
EXW58_12625	COG0745	RESPONSE REGULATOR receiver
EXW58_12635	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW58_12645	COG2205	protein histidine kinase activity
EXW58_12665	COG4720	Psort location CytoplasmicMembrane, score
EXW58_12670	COG1794	racemase activity, acting on amino acids and derivatives
EXW58_12675	COG1819	glycosyl
EXW58_12685	COG0768	penicillin binding
EXW58_12690	COG5002	protein histidine kinase activity
EXW58_12695	COG0561	phosphatase activity
EXW58_12730	COG2124	cytochrome p450
EXW58_12740	COG3344	reverse transcriptase
EXW58_12785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW58_12795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_12820	COG0577	efflux transmembrane transporter activity
EXW58_12825	COG1136	(ABC) transporter
EXW58_12835	COG0488	(ABC) transporter
EXW58_12840	COG0667	Aldo Keto reductase
EXW58_12845	COG0583	DNA-binding transcription factor activity
EXW58_12850	COG2205	protein histidine kinase activity
EXW58_12855	COG0745	RESPONSE REGULATOR receiver
EXW58_12865	COG3773	Cell wall hydrolase
EXW58_12870	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW58_12880	COG0604	alcohol dehydrogenase
EXW58_12910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_12925	COG2959	enzyme of heme biosynthesis
EXW58_12950	COG3483	tryptophan 2,3-dioxygenase activity
EXW58_12960	COG3844	kynureninase activity
EXW58_12965	COG1309	transcriptional regulator
EXW58_12980	COG3284	Transcriptional regulator
EXW58_12995	COG1349	DNA-binding transcription factor activity
EXW58_13030	COG2207	Transcriptional regulator
EXW58_13035	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_13040	COG0456	acetyltransferase
EXW58_13040	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW58_13050	COG2816	NAD+ diphosphatase activity
EXW58_13085	COG4176	ABC-type proline glycine betaine transport system permease component
EXW58_13090	COG0517	IMP dehydrogenase activity
EXW58_13090	COG4175	Glycine betaine
EXW58_13115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW58_13120	COG2153	protein acetylation
EXW58_13125	COG1819	glycosyl
EXW58_13145	COG2205	protein histidine kinase activity
EXW58_13150	COG2315	Protein conserved in bacteria
EXW58_13195	COG3973	AAA domain
EXW58_13200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW58_13210	COG3344	reverse transcriptase
EXW58_13225	COG0514	ATP-dependent DNA helicase (RecQ)
EXW58_13250	COG4637	Psort location Cytoplasmic, score
EXW58_13260	COG1227	inorganic diphosphatase activity
EXW58_13265	COG2318	DinB family
EXW58_13280	COG1162	GTPase activity
EXW58_13285	COG1115	amino acid carrier protein
EXW58_13290	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_13295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW58_13305	COG3938	Belongs to the proline racemase family
EXW58_13310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW58_13355	COG0586	Pfam SNARE associated Golgi protein
EXW58_13370	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW58_13375	COG4166	transmembrane transport
EXW58_13385	COG4948	Mandelate Racemase Muconate Lactonizing
EXW58_13405	COG0667	Aldo Keto reductase
EXW58_13455	COG2936	dipeptidyl-peptidase activity
EXW58_13460	COG5002	protein histidine kinase activity
EXW58_13465	COG0745	RESPONSE REGULATOR receiver
EXW58_13490	COG1164	Oligoendopeptidase f
EXW58_13515	COG1307	EDD domain protein, DegV family
EXW58_13555	COG2814	Major facilitator Superfamily
EXW58_13565	COG1664	Polymer-forming cytoskeletal
EXW58_13570	COG0789	Transcriptional regulator
EXW58_13575	COG4533	DNA binding
EXW58_13580	COG2814	Major facilitator Superfamily
EXW58_13580	COG0477	Major facilitator Superfamily
EXW58_13595	COG2261	transglycosylase associated protein
EXW58_13610	COG2226	methyltransferase
EXW58_13645	COG0436	Aminotransferase
EXW58_13650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW58_13705	COG0628	permease
EXW58_13730	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW58_13755	COG0697	spore germination
EXW58_13775	COG4912	Dna alkylation repair
EXW58_13810	COG2814	Major facilitator Superfamily
EXW58_13815	COG1368	sulfuric ester hydrolase activity
EXW58_13825	COG0488	(ABC) transporter
EXW58_13840	COG1309	transcriptional regulator
EXW58_13855	COG0287	Prephenate dehydrogenase
EXW58_13870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW58_13870	COG1605	Chorismate mutase
EXW58_13915	COG0346	lactoylglutathione lyase activity
EXW58_13925	COG0277	FAD linked oxidase domain protein
EXW58_13945	COG2610	gluconate transmembrane transporter activity
EXW58_13950	COG1024	Enoyl-CoA hydratase
EXW58_13960	COG3290	protein histidine kinase activity
EXW58_13960	COG3829	transcription factor binding
EXW58_13970	COG0579	oxidoreductase
EXW58_13975	COG1879	ABC-type sugar transport system periplasmic component
EXW58_13985	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW58_13995	COG2390	Transcriptional regulator
EXW58_14000	COG1070	Carbohydrate kinase
EXW58_14015	COG2226	methyltransferase
EXW58_14050	COG0346	lactoylglutathione lyase activity
EXW58_14055	COG2329	Antibiotic biosynthesis monooxygenase
EXW58_14075	COG1472	Belongs to the glycosyl hydrolase 3 family
EXW58_14080	COG2207	Transcriptional regulator
EXW58_14085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_14090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW58_14095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW58_14100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW58_14105	COG3239	Fatty acid desaturase
EXW58_14120	COG3842	ATPase activity
EXW58_14145	COG1175	transmembrane transport
EXW58_14150	COG1349	DNA-binding transcription factor activity
EXW58_14160	COG3655	Transcriptional regulator
EXW58_14180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_14185	COG0346	lactoylglutathione lyase activity
EXW58_14210	COG0714	Associated with various cellular activities
EXW58_14230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW58_14235	COG0753	catalase activity
EXW58_14260	COG2801	Transposase and inactivated derivatives
EXW58_14285	COG0714	Associated with various cellular activities
EXW58_14295	COG0778	Nitroreductase
EXW58_14300	COG1846	Transcriptional regulator
EXW58_14330	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW58_14345	COG0824	Thioesterase
EXW58_14350	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_14355	COG0183	Belongs to the thiolase family
EXW58_14360	COG1024	Enoyl-CoA hydratase
EXW58_14365	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW58_14370	COG2723	6-phospho-beta-galactosidase activity
EXW58_14375	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW58_14380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW58_14395	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW58_14405	COG2508	Transcriptional regulator
EXW58_14410	COG2814	Major facilitator Superfamily
EXW58_14445	COG0577	efflux transmembrane transporter activity
EXW58_14445	COG1136	(ABC) transporter
EXW58_14460	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_14465	COG1309	transcriptional regulator
EXW58_14490	COG0456	acetyltransferase
EXW58_14505	COG0697	spore germination
EXW58_14510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_14530	COG0642	Histidine kinase
EXW58_14535	COG0745	RESPONSE REGULATOR receiver
EXW58_14540	COG0596	Alpha beta hydrolase
EXW58_14550	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW58_14550	COG0456	acetyltransferase
EXW58_14575	COG0730	response to heat
EXW58_14585	COG0833	amino acid
EXW58_14595	COG4335	DNA alkylation repair
EXW58_14620	COG0768	penicillin binding
EXW58_14635	COG3104	oligopeptide transport
EXW58_14640	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW58_14655	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW58_14660	COG1984	allophanate hydrolase subunit 2
EXW58_14665	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW58_14670	COG1414	Transcriptional regulator
EXW58_14695	COG1960	acyl-CoA dehydrogenase activity
EXW58_14730	COG0640	Transcriptional regulator
EXW58_14755	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW58_14775	COG3848	Pyruvate phosphate dikinase
EXW58_14775	COG0574	Belongs to the PEP-utilizing enzyme family
EXW58_14825	COG0798	PFAM Bile acid sodium symporter
EXW58_14830	COG0346	lactoylglutathione lyase activity
EXW58_14835	COG0640	Transcriptional regulator
EXW58_14850	COG0346	lactoylglutathione lyase activity
EXW58_14880	COG0745	RESPONSE REGULATOR receiver
EXW58_14885	COG5002	protein histidine kinase activity
EXW58_14885	COG3850	Histidine kinase
EXW58_14930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW58_14935	COG3344	reverse transcriptase
EXW58_14945	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW58_14960	COG2309	aminopeptidase activity
EXW58_14965	COG2226	methyltransferase
EXW58_14970	COG1690	Belongs to the RtcB family
EXW58_14985	COG0789	Transcriptional regulator
EXW58_15000	COG0277	FAD linked oxidase domain protein
EXW58_15005	COG1136	(ABC) transporter
EXW58_15010	COG0577	efflux transmembrane transporter activity
EXW58_15025	COG5002	protein histidine kinase activity
EXW58_15025	COG3850	Histidine kinase
EXW58_15040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_15080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW58_15100	COG1595	DNA-templated transcription, initiation
EXW58_15150	COG2814	Major facilitator Superfamily
EXW58_15190	COG1876	peptidase activity
EXW58_15195	COG2843	Capsule synthesis protein
EXW58_15210	COG0477	Major facilitator Superfamily
EXW58_15225	COG1846	Transcriptional regulator
EXW58_15230	COG2814	Major facilitator Superfamily
EXW58_15245	COG2814	Major facilitator Superfamily
EXW58_15325	COG0384	phenazine biosynthesis protein PhzF
EXW58_15350	COG4187	Peptidase family M20/M25/M40
EXW58_15355	COG1414	Transcriptional regulator
EXW58_15365	COG0833	amino acid
EXW58_15385	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW58_15440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW58_15445	COG2356	endonuclease I
EXW58_15450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW58_15460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW58_15480	COG1785	Belongs to the alkaline phosphatase family
EXW58_15495	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_15505	COG1131	(ABC) transporter
EXW58_15530	COG1011	Hydrolase
EXW58_15535	COG2365	Tyrosine phosphatase family
EXW58_15560	COG0346	lactoylglutathione lyase activity
EXW58_15565	COG1940	carbohydrate kinase activity
EXW58_15570	COG0738	Major facilitator superfamily
EXW58_15575	COG0110	maltose O-acetyltransferase activity
EXW58_15590	COG0628	permease
EXW58_15605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW58_15610	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW58_15620	COG1253	flavin adenine dinucleotide binding
EXW58_15625	COG0789	Transcriptional regulator
EXW58_15630	COG0697	spore germination
EXW58_15640	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW58_15645	COG3813	Protein conserved in bacteria
EXW58_15650	COG4702	Belongs to the UPF0303 family
EXW58_15660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_15675	COG0494	nUDIX hydrolase
EXW58_15700	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW58_15705	COG1733	regulation of RNA biosynthetic process
EXW58_15720	COG1191	sigma factor activity
EXW58_15755	COG5002	protein histidine kinase activity
EXW58_15800	COG0814	amino acid
EXW58_15825	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_15830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW58_15835	COG3800	Transcriptional regulator
EXW58_15835	COG1396	sequence-specific DNA binding
EXW58_15870	COG1151	hydroxylamine reductase activity
EXW58_15900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW58_15910	COG2072	flavoprotein involved in K transport
EXW58_15955	COG0604	alcohol dehydrogenase
EXW58_15960	COG1113	amino acid transport
EXW58_15975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW58_15990	COG0534	Mate efflux family protein
EXW58_15995	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_16000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW58_16015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW58_16035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_16040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_16045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_16050	COG3739	integral membrane protein
EXW58_16065	COG0583	DNA-binding transcription factor activity
EXW58_16085	COG1193	negative regulation of DNA recombination
EXW58_16095	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW58_16100	COG1164	Oligoendopeptidase f
EXW58_16125	COG3781	membrane
EXW58_16140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW58_16160	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW58_16165	COG0457	Tetratricopeptide repeat
EXW58_16175	COG2808	Putative FMN-binding domain
EXW58_16185	COG0277	FAD linked oxidase domain protein
EXW58_16205	COG2514	catechol 2,3-dioxygenase activity
EXW58_16210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_16215	COG1126	abc transporter atp-binding protein
EXW58_16220	COG0765	amino acid transport
EXW58_16225	COG2720	vancomycin resistance protein
EXW58_16240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW58_16240	COG4451	ribulose bisphosphate carboxylase, small
EXW58_16260	COG1278	Cold shock
EXW58_16270	COG0716	FMN binding
EXW58_16280	COG1051	belongs to the nudix hydrolase family
EXW58_16290	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_16300	COG0165	Argininosuccinate lyase
EXW58_16315	COG4145	pantothenate transmembrane transporter activity
EXW58_16325	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_16330	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_16340	COG1657	PFAM Prenyltransferase squalene oxidase
EXW58_16345	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW58_16350	COG2962	Rard protein
EXW58_16355	COG3326	Membrane
EXW58_16360	COG0531	amino acid
EXW58_16395	COG2226	methyltransferase
EXW58_16400	COG4166	transmembrane transport
EXW58_16405	COG4166	transmembrane transport
EXW58_16410	COG4166	transmembrane transport
EXW58_16415	COG1316	TRANSCRIPTIONal
EXW58_16425	COG1595	DNA-templated transcription, initiation
EXW58_16435	COG1131	(ABC) transporter
EXW58_16445	COG0673	inositol 2-dehydrogenase activity
EXW58_16450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW58_16455	COG0187	DNA topoisomerase II activity
EXW58_16460	COG1832	CoA-binding protein
EXW58_16465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW58_16470	COG0745	RESPONSE REGULATOR receiver
EXW58_16480	COG1328	CTP reductase activity
EXW58_16490	COG4841	protein insertion into membrane
EXW58_16495	COG0824	Thioesterase
EXW58_16520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_16545	COG1266	CAAX protease self-immunity
EXW58_16550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW58_16580	COG2211	Major facilitator Superfamily
EXW58_16590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW58_16625	COG0183	Belongs to the thiolase family
EXW58_16635	COG1268	BioY protein
EXW58_16640	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_16690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_16700	COG5002	protein histidine kinase activity
EXW58_16705	COG0400	carboxylic ester hydrolase activity
EXW58_16715	COG0069	glutamate synthase activity
EXW58_16720	COG1902	pentaerythritol trinitrate reductase activity
EXW58_16725	COG1329	Transcriptional regulator
EXW58_16730	COG0010	Belongs to the arginase family
EXW58_16740	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW58_16745	COG2986	histidine ammonia-lyase
EXW58_16755	COG2226	methyltransferase
EXW58_16785	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW58_16790	COG0785	Cytochrome C biogenesis protein
EXW58_16805	COG1473	amidohydrolase
EXW58_16810	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW58_16815	COG1131	(ABC) transporter
EXW58_16830	COG0583	DNA-binding transcription factor activity
EXW58_16840	COG1346	cytolysis
EXW58_16870	COG1132	(ABC) transporter
EXW58_16875	COG1132	(ABC) transporter
EXW58_16880	COG3763	UPF0154 protein
EXW58_16895	COG3639	organic phosphonate transmembrane transporter activity
EXW58_16900	COG3639	organic phosphonate transmembrane transporter activity
EXW58_16910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_16915	COG0737	Belongs to the 5'-nucleotidase family
EXW58_16925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW58_16930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW58_16945	COG1695	Transcriptional regulator
EXW58_16950	COG1132	(ABC) transporter
EXW58_16980	COG0367	asparagine synthase
EXW58_16985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW58_16995	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXW58_17000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW58_17050	COG3344	reverse transcriptase
EXW58_17070	COG0463	Glycosyl transferase, family 2
EXW58_17070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW58_17075	COG0438	transferase activity, transferring glycosyl groups
EXW58_17080	COG0438	transferase activity, transferring glycosyl groups
EXW58_17085	COG1086	Polysaccharide biosynthesis protein
EXW58_17090	COG0489	protein tyrosine kinase activity
EXW58_17100	COG0174	glutamine synthetase
EXW58_17105	COG0789	Transcriptional regulator
EXW58_17110	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW58_17115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW58_17120	COG2860	membrane
EXW58_17125	COG0464	growth
EXW58_17155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW58_17165	COG1388	LysM domain
EXW58_17165	COG3584	3D domain protein
EXW58_17170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW58_17170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW58_17170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW58_17175	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW58_17180	COG1349	DNA-binding transcription factor activity
EXW58_17185	COG1979	alcohol dehydrogenase
EXW58_17190	COG2322	membrane
EXW58_17200	COG1473	amidohydrolase
EXW58_17205	COG1408	metallophosphoesterase
EXW58_17210	COG2116	formate transmembrane transporter activity
EXW58_17225	COG2217	Heavy metal translocating P-type atpase
EXW58_17230	COG2608	mercury ion transmembrane transporter activity
EXW58_17235	COG1937	Protein conserved in bacteria
EXW58_17265	COG2819	hydrolase of the alpha beta superfamily
EXW58_17270	COG1120	ATPase activity
EXW58_17275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_17280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_17285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_17290	COG0708	Exodeoxyribonuclease III
EXW58_17295	COG2169	Transcriptional regulator
EXW58_17300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW58_17305	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW58_17310	COG2706	6-phosphogluconolactonase activity
EXW58_17315	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW58_17320	COG2364	Membrane
EXW58_17335	COG0346	lactoylglutathione lyase activity
EXW58_17340	COG3300	MHYT domain
EXW58_17340	COG5001	Diguanylate cyclase
EXW58_17380	COG1346	cytolysis
EXW58_17390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW58_17395	COG2945	thiolester hydrolase activity
EXW58_17395	COG0596	Alpha beta hydrolase
EXW58_17400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW58_17410	COG3344	reverse transcriptase
EXW58_17420	COG2188	Transcriptional regulator
EXW58_17425	COG2723	6-phospho-beta-galactosidase activity
EXW58_17435	COG3773	Cell wall hydrolase
EXW58_17445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW58_17455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW58_17460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW58_17470	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW58_17475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW58_17480	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW58_17485	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW58_17485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW58_17495	COG2359	stage V sporulation protein S
EXW58_17500	COG1692	metallophosphoesterase
EXW58_17505	COG1418	mRNA catabolic process
EXW58_17510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW58_17525	COG1546	Belongs to the CinA family
EXW58_17525	COG1058	Belongs to the CinA family
EXW58_17530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW58_17535	COG1426	Protein conserved in bacteria
EXW58_17550	COG0300	oxidoreductase activity
EXW58_17555	COG0612	Peptidase, M16
EXW58_17560	COG0612	Peptidase, M16
EXW58_17565	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW58_17570	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW58_17575	COG3845	ABC transporter
EXW58_17580	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW58_17585	COG2188	Transcriptional regulator
EXW58_17595	COG1674	ftsk spoiiie
EXW58_17605	COG0740	serine-type endopeptidase activity
EXW58_17610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW58_17620	COG0527	aspartate kinase activity
EXW58_17625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW58_17630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW58_17635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW58_17640	COG1873	PFAM PRC-barrel domain
EXW58_17645	COG0612	Peptidase, M16
EXW58_17650	COG0726	polysaccharide deacetylase
EXW58_17655	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW58_17665	COG0196	riboflavin kinase activity
EXW58_17675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW58_17680	COG1550	Protein conserved in bacteria
EXW58_17685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW58_17690	COG1358	cellular component organization or biogenesis
EXW58_17695	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW58_17700	COG0195	Participates in both transcription termination and antitermination
EXW58_17715	COG0442	prolyl-tRNA aminoacylation
EXW58_17720	COG0750	zinc metalloprotease
EXW58_17730	COG4589	Belongs to the CDS family
EXW58_17740	COG0233	cytoplasmic translational termination
EXW58_17745	COG0528	UMP kinase activity
EXW58_17750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW58_17755	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW58_17760	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW58_17765	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW58_17770	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW58_17775	COG4974	Belongs to the 'phage' integrase family
EXW58_17780	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW58_17785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW58_17790	COG0758	DNA mediated transformation
EXW58_17795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW58_17800	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW58_17805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW58_17820	COG0335	large ribosomal subunit rRNA binding
EXW58_17825	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW58_17830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW58_17835	COG1837	Belongs to the UPF0109 family
EXW58_17845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW58_17855	COG0552	protein localization to endoplasmic reticulum
EXW58_17860	COG1196	nuclear chromosome segregation
EXW58_17865	COG0571	ribonuclease III activity
EXW58_17870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW58_17875	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_17880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW58_17885	COG0416	fatty acid biosynthetic process
EXW58_17895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW58_17900	COG1461	Dihydroxyacetone kinase
EXW58_17905	COG1302	Protein conserved in bacteria
EXW58_17920	COG1564	THIamine pyrophosphokinase
EXW58_17925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW58_17935	COG0515	serine threonine protein kinase
EXW58_17935	COG2815	serine threonine protein kinase
EXW58_17940	COG0631	protein serine/threonine phosphatase activity
EXW58_17945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW58_17950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW58_17950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW58_17955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW58_17960	COG0242	peptide deformylase activity
EXW58_17965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW58_17970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW58_17975	COG1758	RNA polymerase activity
EXW58_17990	COG1561	YicC-like family, N-terminal region
EXW58_17995	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW58_18010	COG0006	proline dipeptidase activity
EXW58_18025	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW58_18050	COG0167	dihydroorotate dehydrogenase activity
EXW58_18055	COG0543	2 iron, 2 sulfur cluster binding
EXW58_18060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW58_18070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW58_18075	COG0540	Belongs to the ATCase OTCase family
EXW58_18085	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW58_18090	COG0564	pseudouridine synthase activity
EXW58_18110	COG3599	regulation of cell shape
EXW58_18115	COG2302	S4 RNA-binding domain
EXW58_18120	COG0762	integral membrane protein
EXW58_18125	COG1799	cell septum assembly
EXW58_18130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW58_18140	COG1873	PFAM PRC-barrel domain
EXW58_18145	COG1191	sigma factor activity
EXW58_18150	COG1191	sigma factor activity
EXW58_18160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW58_18165	COG0849	cell division
EXW58_18170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW58_18185	COG0772	Belongs to the SEDS family
EXW58_18190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW58_18195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW58_18200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW58_18205	COG0768	penicillin binding
EXW58_18210	COG0768	penicillin binding
EXW58_18220	COG0275	rRNA processing
EXW58_18225	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW58_18230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW58_18235	COG0454	-acetyltransferase
EXW58_18245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW58_18250	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW58_18255	COG1323	Belongs to the UPF0348 family
EXW58_18260	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW58_18265	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW58_18270	COG3314	Sporulation integral membrane protein YlbJ
EXW58_18280	COG0742	ribosomal rna small subunit methyltransferase
EXW58_18290	COG4471	UPF0298 protein
EXW58_18295	COG3679	Belongs to the UPF0342 family
EXW58_18300	COG0406	alpha-ribazole phosphatase activity
EXW58_18315	COG2340	Cysteine-rich secretory protein family
EXW58_18325	COG3336	cytochrome c oxidase
EXW58_18350	COG0109	protoheme IX farnesyltransferase activity
EXW58_18355	COG1612	heme a metabolic process
EXW58_18360	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW58_18370	COG0772	Belongs to the SEDS family
EXW58_18375	COG4838	Belongs to the UPF0358 family
EXW58_18380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW58_18385	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW58_18395	COG4896	Protein conserved in bacteria
EXW58_18410	COG1217	gtp-binding protein TYPA
EXW58_18420	COG0483	inositol monophosphate 1-phosphatase activity
EXW58_18430	COG4493	Belongs to the UPF0637 family
EXW58_18435	COG4476	Belongs to the UPF0223 family
EXW58_18440	COG1982	Orn Lys Arg decarboxylase major
EXW58_18485	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW58_18490	COG0022	dehydrogenase e1 component
EXW58_18495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW58_18510	COG0561	phosphatase activity
EXW58_18520	COG5503	Protein of unknown function (DUF1447)
EXW58_18525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW58_18530	COG0569	domain protein
EXW58_18540	COG1473	amidohydrolase
EXW58_18545	COG2171	N-acyltransferase activity
EXW58_18550	COG0583	DNA-binding transcription factor activity
EXW58_18555	COG0517	IMP dehydrogenase activity
EXW58_18565	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW58_18570	COG4703	Protein of unknown function (DUF1797)
EXW58_18585	COG2200	EAL domain
EXW58_18590	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_18595	COG1408	metallophosphoesterase
EXW58_18640	COG2814	Major facilitator Superfamily
EXW58_18650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW58_18660	COG3209	COG3209 Rhs family protein
EXW58_18670	COG2205	protein histidine kinase activity
EXW58_18680	COG0436	Aminotransferase
EXW58_18685	COG1609	Transcriptional regulator
EXW58_18690	COG3833	ABC-type maltose transport systems, permease component
EXW58_18695	COG1175	transmembrane transport
EXW58_18700	COG2182	Extracellular solute-binding protein
EXW58_18710	COG0366	Alpha amylase catalytic
EXW58_18715	COG3842	ATPase activity
EXW58_18755	COG0183	Belongs to the thiolase family
EXW58_18790	COG1695	Transcriptional regulator
EXW58_18795	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_18810	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW58_18820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW58_18825	COG0436	Aminotransferase
EXW58_18830	COG1850	ribulose-bisphosphate carboxylase activity
EXW58_18835	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW58_18840	COG0235	Class ii aldolase
EXW58_18845	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW58_18860	COG2084	Dehydrogenase
EXW58_18870	COG2199	diguanylate cyclase activity
EXW58_18875	COG0778	Nitroreductase
EXW58_18900	COG2190	(PTS) system
EXW58_18900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_18900	COG1263	PTS System
EXW58_18905	COG3711	transcriptional antiterminator
EXW58_18915	COG2188	Transcriptional regulator
EXW58_18920	COG0363	glucosamine-6-phosphate deaminase activity
EXW58_18925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW58_18935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW58_18945	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW58_18955	COG1547	Domain of unknown function (DUF309)
EXW58_18965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW58_18970	COG4086	secreted protein
EXW58_18975	COG0561	phosphatase activity
EXW58_18990	COG0697	spore germination
EXW58_19005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW58_19045	COG1686	Belongs to the peptidase S11 family
EXW58_19055	COG1725	Transcriptional regulator
EXW58_19060	COG1131	(ABC) transporter
EXW58_19080	COG1846	Transcriptional regulator
EXW58_19095	COG0598	Magnesium transport protein CorA
EXW58_19110	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW58_19120	COG4974	Belongs to the 'phage' integrase family
EXW58_19130	COG0735	belongs to the Fur family
EXW58_19135	COG1300	Membrane
EXW58_19155	COG0667	Aldo Keto reductase
EXW58_19160	COG0656	L-ascorbic acid biosynthetic process
EXW58_19165	COG0456	acetyltransferase
EXW58_19165	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW58_19175	COG4085	toxin activity
EXW58_19175	COG1525	nuclease
EXW58_19175	COG0737	Belongs to the 5'-nucleotidase family
EXW58_19180	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW58_19190	COG0596	Alpha beta hydrolase
EXW58_19195	COG2056	Na+-H+ antiporter family
EXW58_19200	COG1609	Transcriptional regulator
EXW58_19205	COG0456	acetyltransferase
EXW58_19210	COG1073	alpha beta
EXW58_19225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW58_19225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW58_19230	COG0307	riboflavin synthase, alpha
EXW58_19235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW58_19235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW58_19250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW58_19260	COG1073	alpha beta
EXW58_19260	COG2226	methyltransferase
EXW58_19265	COG0156	8-amino-7-oxononanoate synthase activity
EXW58_19275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW58_19290	COG1757	Na H antiporter
EXW58_19300	COG0737	Belongs to the 5'-nucleotidase family
EXW58_19310	COG1522	sequence-specific DNA binding
EXW58_19330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW58_19335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXW58_19345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW58_19355	COG0300	oxidoreductase activity
EXW58_19360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_19365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW58_19370	COG1760	l-serine dehydratase
EXW58_19375	COG1760	l-serine dehydratase
EXW58_19380	COG1234	tRNA 3'-trailer cleavage
EXW58_19410	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW58_19415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_19425	COG1376	ErfK ybiS ycfS ynhG family protein
EXW58_19430	COG4129	membrane
EXW58_19435	COG1126	abc transporter atp-binding protein
EXW58_19440	COG0765	amino acid transport
EXW58_19445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW58_19455	COG2816	NAD+ diphosphatase activity
EXW58_19460	COG2323	membrane
EXW58_19465	COG0772	Belongs to the SEDS family
EXW58_19470	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW58_19475	COG0022	dehydrogenase e1 component
EXW58_19480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW58_19485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW58_19490	COG3426	butyrate kinase activity
EXW58_19500	COG0280	phosphate acetyltransferase
EXW58_19510	COG3290	protein histidine kinase activity
EXW58_19510	COG3829	transcription factor binding
EXW58_19520	COG0584	glycerophosphoryl diester phosphodiesterase
EXW58_19525	COG3093	addiction module antidote protein HigA
EXW58_19530	COG3344	reverse transcriptase
EXW58_19545	COG0745	RESPONSE REGULATOR receiver
EXW58_19560	COG0750	zinc metalloprotease
EXW58_19565	COG0497	DNA recombination
EXW58_19570	COG1438	arginine binding
EXW58_19575	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW58_19580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW58_19585	COG0142	geranyltranstransferase activity
EXW58_19590	COG1722	exodeoxyribonuclease VII activity
EXW58_19600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW58_19605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW58_19610	COG1302	Protein conserved in bacteria
EXW58_19615	COG0439	Biotin carboxylase
EXW58_19620	COG0511	ligase activity, forming carbon-carbon bonds
EXW58_19665	COG3854	ATPases associated with a variety of cellular activities
EXW58_19685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW58_19690	COG0006	proline dipeptidase activity
EXW58_19705	COG3872	metal-dependent enzyme
EXW58_19715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW58_19740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW58_19750	COG1609	Transcriptional regulator
EXW58_19760	COG2076	Multidrug Resistance protein
EXW58_19765	COG2076	Multidrug Resistance protein
EXW58_19800	COG1725	Transcriptional regulator
EXW58_19815	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW58_19820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW58_19825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW58_19830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW58_19860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW58_19885	COG4970	Tfp pilus assembly protein FimT
EXW58_19890	COG4537	Required for transformation and DNA binding
EXW58_19895	COG1459	type II secretion system
EXW58_19900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW58_19955	COG0646	methionine synthase
EXW58_19955	COG1410	methionine synthase
EXW58_19960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW58_19960	COG0646	methionine synthase
EXW58_19965	COG0626	cystathionine gamma-synthase activity
EXW58_19970	COG0626	cystathionine gamma-synthase activity
EXW58_19990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_20000	COG1940	carbohydrate kinase activity
EXW58_20005	COG4483	Protein conserved in bacteria
EXW58_20010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW58_20015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW58_20020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW58_20025	COG0704	Plays a role in the regulation of phosphate uptake
EXW58_20035	COG0581	inorganic phosphate transmembrane transporter activity
EXW58_20040	COG0573	inorganic phosphate transmembrane transporter activity
EXW58_20045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW58_20050	COG0768	penicillin binding
EXW58_20055	COG0477	Major facilitator Superfamily
EXW58_20060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW58_20080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW58_20085	COG0735	belongs to the Fur family
EXW58_20090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW58_20095	COG1121	(ABC) transporter
EXW58_20100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_20110	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW58_20130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW58_20135	COG2384	SAM-dependent methyltransferase
EXW58_20140	COG2010	Cytochrome c
EXW58_20145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW58_20150	COG0358	DNA primase activity
EXW58_20160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW58_20165	COG0517	IMP dehydrogenase activity
EXW58_20170	COG1381	Involved in DNA repair and RecF pathway recombination
EXW58_20180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW58_20185	COG0295	cytidine deaminase activity
EXW58_20190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW58_20195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW58_20200	COG1480	7TM receptor with intracellular HD hydrolase
EXW58_20205	COG1702	phosphate starvation-inducible protein PhoH
EXW58_20220	COG1610	YqeY-like protein
EXW58_20225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW58_20230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW58_20235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW58_20245	COG0484	heat shock protein binding
EXW58_20250	COG0443	Heat shock 70 kDa protein
EXW58_20260	COG1420	regulation of RNA biosynthetic process
EXW58_20265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW58_20275	COG0481	GTPase activity
EXW58_20285	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW58_20290	COG0268	Binds directly to 16S ribosomal RNA
EXW58_20295	COG1466	dna polymerase III delta subunit
EXW58_20305	COG0658	competence protein
EXW58_20305	COG2333	competence protein COMEC
EXW58_20310	COG2131	deaminase
EXW58_20315	COG1596	polysaccharide export
EXW58_20315	COG1555	photosystem II stabilization
EXW58_20320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW58_20325	COG2226	methyltransferase
EXW58_20330	COG0799	negative regulation of ribosome biogenesis
EXW58_20335	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW58_20340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW58_20345	COG1534	Rna-binding protein
EXW58_20350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW58_20355	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW58_20360	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW58_20370	COG0688	phosphatidylethanolamine metabolic process
EXW58_20390	COG2357	RelA SpoT domain protein
EXW58_20400	COG1785	Belongs to the alkaline phosphatase family
EXW58_20410	COG2267	carboxylic ester hydrolase activity
EXW58_20445	COG1404	Belongs to the peptidase S8 family
EXW58_20450	COG3186	Phenylalanine-4-hydroxylase
EXW58_20460	COG2514	catechol 2,3-dioxygenase activity
EXW58_20465	COG2259	Doxx family
EXW58_20505	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW58_20520	COG1454	alcohol dehydrogenase
EXW58_20520	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_20525	COG0626	cystathionine gamma-synthase activity
EXW58_20530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW58_20535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW58_20540	COG2226	methyltransferase
EXW58_20555	COG0768	penicillin binding
EXW58_20560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW58_20565	COG0572	uridine kinase
EXW58_20570	COG0826	peptidase U32
EXW58_20575	COG0826	peptidase U32
EXW58_20580	COG4122	O-methyltransferase activity
EXW58_20585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW58_20595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW58_20605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW58_20610	COG0628	permease
EXW58_20630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW58_20640	COG0482	sulfurtransferase activity
EXW58_20645	COG1104	cysteine desulfurase activity
EXW58_20650	COG1959	2 iron, 2 sulfur cluster binding
EXW58_20655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW58_20665	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW58_20670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW58_20680	COG1490	D-aminoacyl-tRNA deacylase activity
EXW58_20685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW58_20690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW58_20695	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW58_20695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW58_20700	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW58_20705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW58_20705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW58_20715	COG2244	polysaccharide biosynthetic process
EXW58_20720	COG2323	membrane
EXW58_20730	COG1862	Preprotein translocase
EXW58_20735	COG0343	queuine tRNA-ribosyltransferase activity
EXW58_20750	COG2255	four-way junction helicase activity
EXW58_20755	COG0632	four-way junction helicase activity
EXW58_20760	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW58_20785	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW58_20790	COG0157	Belongs to the NadC ModD family
EXW58_20795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW58_20800	COG1104	cysteine desulfurase activity
EXW58_20805	COG1827	regulation of RNA biosynthetic process
EXW58_20810	COG2258	MOSC domain
EXW58_20815	COG0077	Prephenate dehydratase
EXW58_20820	COG0577	efflux transmembrane transporter activity
EXW58_20825	COG0577	efflux transmembrane transporter activity
EXW58_20830	COG1136	(ABC) transporter
EXW58_20835	COG5002	protein histidine kinase activity
EXW58_20840	COG0745	RESPONSE REGULATOR receiver
EXW58_20845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW58_20850	COG3290	protein histidine kinase activity
EXW58_20860	COG2868	ribosomal protein
EXW58_20870	COG1530	ribonuclease E activity
EXW58_20875	COG1994	Peptidase M50
EXW58_20880	COG0739	heme binding
EXW58_20885	COG2894	cell division
EXW58_20890	COG0850	regulation of cytokinetic process
EXW58_20905	COG1077	Cell shape determining protein MreB Mrl
EXW58_20910	COG2003	Belongs to the UPF0758 family
EXW58_20915	COG0424	maF-like protein
EXW58_20930	COG0285	dihydrofolate synthase activity
EXW58_20945	COG1388	LysM domain
EXW58_20950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW58_20955	COG0113	porphobilinogen synthase activity
EXW58_20960	COG1587	Uroporphyrinogen-III synthase
EXW58_20965	COG0181	hydroxymethylbilane synthase activity
EXW58_20970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW58_20975	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW58_20980	COG1846	Transcriptional regulator
EXW58_20985	COG1764	response to oxidative stress
EXW58_20990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW58_21000	COG0470	DNA polymerase III
EXW58_21000	COG1067	ATP-dependent peptidase activity
EXW58_21010	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW58_21040	COG0622	Phosphoesterase
EXW58_21050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW58_21055	COG5401	PFAM Sporulation and spore germination
EXW58_21080	COG2197	response regulator
EXW58_21085	COG2233	PERMEase
EXW58_21090	COG0402	S-adenosylhomocysteine deaminase activity
EXW58_21095	COG1983	PspC domain protein
EXW58_21100	COG1396	sequence-specific DNA binding
EXW58_21105	COG0697	spore germination
EXW58_21115	COG1959	2 iron, 2 sulfur cluster binding
EXW58_21120	COG1668	transmembrane transport
EXW58_21125	COG4152	abc transporter atp-binding protein
EXW58_21130	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW58_21135	COG1360	Flagellar Motor Protein
EXW58_21140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW58_21145	COG1876	peptidase activity
EXW58_21150	COG0824	Thioesterase
EXW58_21155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW58_21160	COG1053	succinate dehydrogenase
EXW58_21165	COG2009	succinate dehydrogenase
EXW58_21170	COG1719	4-vinyl reductase, 4VR
EXW58_21175	COG0322	excinuclease ABC activity
EXW58_21180	COG3118	belongs to the thioredoxin family
EXW58_21185	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW58_21190	COG2086	electron transfer activity
EXW58_21195	COG1024	Enoyl-CoA hydratase
EXW58_21200	COG1309	transcriptional regulator
EXW58_21205	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_21215	COG2318	DinB family
EXW58_21240	COG1131	(ABC) transporter
EXW58_21245	COG2205	protein histidine kinase activity
EXW58_21250	COG0745	RESPONSE REGULATOR receiver
EXW58_21255	COG4895	conserved protein (DUF2196)
EXW58_21260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW58_21270	COG4509	Sortase family
EXW58_21275	COG1120	ATPase activity
EXW58_21290	COG5386	Cell surface protein
EXW58_21295	COG5386	Cell surface protein
EXW58_21300	COG1114	Component of the transport system for branched-chain amino acids
EXW58_21305	COG1187	pseudouridine synthase activity
EXW58_21310	COG1193	negative regulation of DNA recombination
EXW58_21315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW58_21315	COG1796	DNA polymerase
EXW58_21320	COG1286	toxin biosynthetic process
EXW58_21325	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW58_21330	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW58_21355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW58_21360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW58_21370	COG1418	mRNA catabolic process
EXW58_21390	COG2814	Major facilitator Superfamily
EXW58_21395	COG1566	PFAM secretion protein HlyD family protein
EXW58_21400	COG1309	transcriptional regulator
EXW58_21405	COG1363	Peptidase, m42
EXW58_21415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW58_21430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW58_21440	COG1484	DNA-dependent DNA replication
EXW58_21445	COG3611	Membrane attachment protein
EXW58_21450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW58_21455	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW58_21460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW58_21465	COG0237	dephospho-CoA kinase activity
EXW58_21470	COG1971	Probably functions as a manganese efflux pump
EXW58_21480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW58_21480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW58_21485	COG5002	protein histidine kinase activity
EXW58_21490	COG0745	RESPONSE REGULATOR receiver
EXW58_21510	COG0538	isocitrate dehydrogenase activity
EXW58_21515	COG0372	Belongs to the citrate synthase family
EXW58_21530	COG0628	permease
EXW58_21535	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW58_21545	COG0205	6-phosphofructokinase activity
EXW58_21560	COG1725	Transcriptional regulator
EXW58_21565	COG0281	malic enzyme
EXW58_21570	COG0587	DNA-directed DNA polymerase activity
EXW58_21585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW58_21605	COG4109	DRTGG domain
EXW58_21610	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW58_21615	COG0006	proline dipeptidase activity
EXW58_21670	COG0662	Cupin 2, conserved barrel domain protein
EXW58_21680	COG1476	TRANSCRIPTIONal
EXW58_21695	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_21700	COG0589	response to stress
EXW58_21720	COG0165	Argininosuccinate lyase
EXW58_21725	COG0137	argininosuccinate synthase activity
EXW58_21745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_21760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW58_21765	COG0827	DNA restriction-modification system
EXW58_21770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW58_21775	COG3874	Sporulation protein YtfJ
EXW58_21790	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW58_21800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW58_21815	COG1104	cysteine desulfurase activity
EXW58_21820	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW58_21835	COG1309	transcriptional regulator
EXW58_21840	COG1956	GAF domain-containing protein
EXW58_21845	COG0626	cystathionine gamma-synthase activity
EXW58_21850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW58_21890	COG1595	DNA-templated transcription, initiation
EXW58_21900	COG0110	maltose O-acetyltransferase activity
EXW58_21905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW58_21910	COG0454	-acetyltransferase
EXW58_21915	COG0517	IMP dehydrogenase activity
EXW58_21920	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW58_21935	COG0745	RESPONSE REGULATOR receiver
EXW58_21940	COG5002	protein histidine kinase activity
EXW58_21945	COG0666	response to abiotic stimulus
EXW58_21975	COG1609	Transcriptional regulator
EXW58_21980	COG4851	CamS sex pheromone cAM373 precursor
EXW58_21985	COG3118	belongs to the thioredoxin family
EXW58_21995	COG2309	aminopeptidase activity
EXW58_22020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_22025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW58_22035	COG1674	ftsk spoiiie
EXW58_22050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW58_22055	COG4848	Belongs to the UPF0354 family
EXW58_22060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_22065	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW58_22070	COG1363	Peptidase, m42
EXW58_22080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_22085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW58_22095	COG0510	thiamine kinase activity
EXW58_22100	COG1523	belongs to the glycosyl hydrolase 13 family
EXW58_22110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW58_22115	COG1349	DNA-binding transcription factor activity
EXW58_22120	COG1187	pseudouridine synthase activity
EXW58_22125	COG2244	polysaccharide biosynthetic process
EXW58_22130	COG2081	HI0933 family
EXW58_22135	COG2814	Major facilitator Superfamily
EXW58_22145	COG3832	glyoxalase III activity
EXW58_22165	COG1329	Transcriptional regulator
EXW58_22180	COG0314	molybdopterin synthase activity
EXW58_22185	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW58_22190	COG0303	'Molybdopterin
EXW58_22195	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW58_22200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW58_22205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW58_22225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW58_22235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW58_22275	COG0495	leucyl-tRNA aminoacylation
EXW58_22280	COG2814	Major facilitator Superfamily
EXW58_22285	COG0475	glutathione-regulated potassium exporter activity
EXW58_22290	COG0490	domain, Protein
EXW58_22295	COG0582	viral genome integration into host DNA
EXW58_22310	COG1136	(ABC) transporter
EXW58_22325	COG1242	4 iron, 4 sulfur cluster binding
EXW58_22330	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW58_22340	COG1131	(ABC) transporter
EXW58_22380	COG2267	carboxylic ester hydrolase activity
EXW58_22385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW58_22390	COG0671	phosphoesterase, PA-phosphatase related
EXW58_22395	COG0438	transferase activity, transferring glycosyl groups
EXW58_22405	COG1404	Belongs to the peptidase S8 family
EXW58_22410	COG1404	Belongs to the peptidase S8 family
EXW58_22420	COG4585	Histidine kinase
EXW58_22425	COG0746	molybdenum cofactor guanylyltransferase activity
EXW58_22430	COG0521	Mo-molybdopterin cofactor biosynthetic process
EXW58_22445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW58_22450	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW58_22485	COG5002	protein histidine kinase activity
EXW58_22490	COG3852	Histidine kinase
EXW58_22495	COG0753	catalase activity
EXW58_22500	COG2267	carboxylic ester hydrolase activity
EXW58_22505	COG1368	sulfuric ester hydrolase activity
EXW58_22510	COG4895	conserved protein (DUF2196)
EXW58_22525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW58_22530	COG1116	anion transmembrane transporter activity
EXW58_22535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW58_22555	COG0494	nUDIX hydrolase
EXW58_22590	COG2723	6-phospho-beta-galactosidase activity
EXW58_22595	COG2723	6-phospho-beta-galactosidase activity
EXW58_22600	COG1263	PTS System
EXW58_22600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW58_22600	COG2190	(PTS) system
EXW58_22605	COG3711	transcriptional antiterminator
EXW58_22615	COG1854	S-ribosylhomocysteine lyase activity
EXW58_22625	COG0288	reversible hydration of carbon dioxide
EXW58_22630	COG1271	oxidase subunit
EXW58_22635	COG1294	oxidase, subunit
EXW58_22650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_22675	COG1842	Phage shock protein A
EXW58_22700	COG3859	Proton-coupled thiamine transporter YuaJ
EXW58_22705	COG5002	protein histidine kinase activity
EXW58_22710	COG0745	RESPONSE REGULATOR receiver
EXW58_22735	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW58_22740	COG1597	lipid kinase activity
EXW58_22755	COG1136	(ABC) transporter
EXW58_22770	COG5002	protein histidine kinase activity
EXW58_22780	COG0586	Pfam SNARE associated Golgi protein
EXW58_22790	COG0577	efflux transmembrane transporter activity
EXW58_22795	COG1136	(ABC) transporter
EXW58_22800	COG2207	Transcriptional regulator
EXW58_22800	COG3708	Transcriptional regulator
EXW58_22805	COG3344	reverse transcriptase
EXW58_22820	COG1131	(ABC) transporter
EXW58_22825	COG5658	integral membrane protein
EXW58_22830	COG0640	Transcriptional regulator
EXW58_22835	COG0745	RESPONSE REGULATOR receiver
EXW58_22840	COG2205	protein histidine kinase activity
EXW58_22845	COG0577	efflux transmembrane transporter activity
EXW58_22850	COG0577	efflux transmembrane transporter activity
EXW58_22855	COG1136	(ABC) transporter
EXW58_22860	COG0577	efflux transmembrane transporter activity
EXW58_22870	COG2801	Transposase and inactivated derivatives
EXW58_22880	COG2188	Transcriptional regulator
EXW58_22900	COG3964	amidohydrolase
EXW58_22920	COG4948	Mandelate Racemase Muconate Lactonizing
EXW58_22925	COG0318	PFAM AMP-dependent synthetase and ligase
EXW58_22930	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW58_22935	COG0596	Alpha beta hydrolase
EXW58_22940	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW58_22945	COG1169	isochorismate synthase
EXW58_22950	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW58_22955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW58_22960	COG1278	Cold shock
EXW58_22975	COG1051	belongs to the nudix hydrolase family
EXW58_22990	COG0058	SHG alpha-glucan phosphorylase activity
EXW58_23000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW58_23005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW58_23010	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW58_23115	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW58_23150	COG1285	pathogenesis
EXW58_23155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW58_23165	COG0166	Belongs to the GPI family
EXW58_23175	COG2155	Conserved Protein
EXW58_23180	COG1098	S1 RNA binding domain
EXW58_23185	COG0436	Aminotransferase
EXW58_23190	COG1522	sequence-specific DNA binding
EXW58_23195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW58_23200	COG2267	carboxylic ester hydrolase activity
EXW58_23210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW58_23225	COG5018	Exonuclease
EXW58_23230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW58_23260	COG2050	protein possibly involved in aromatic compounds catabolism
EXW58_23270	COG1268	BioY protein
EXW58_23280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW58_23285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW58_23295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW58_23300	COG3584	3D domain protein
EXW58_23315	COG1252	NADH dehydrogenase
EXW58_23320	COG0492	ferredoxin-NADP+ reductase activity
EXW58_23345	COG1683	Conserved Protein
EXW58_23355	COG0316	Belongs to the HesB IscA family
EXW58_23360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW58_23365	COG4844	belongs to the
EXW58_23370	COG1252	NADH dehydrogenase
EXW58_23375	COG2274	protein secretion by the type I secretion system
EXW58_23380	COG0390	transport system, permease component
EXW58_23385	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW58_23405	COG4837	Protein of unknown function (DUF1462)
EXW58_23410	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW58_23420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW58_23425	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW58_23455	COG0647	UMP catabolic process
EXW58_23465	COG2445	Protein of unknown function DUF86
EXW58_23470	COG1494	fructose-1,6-bisphosphatase
EXW58_23495	COG4470	Protein conserved in bacteria
EXW58_23505	COG0789	Transcriptional regulator
EXW58_23510	COG4377	Putative membrane peptidase family (DUF2324)
EXW58_23535	COG0739	heme binding
EXW58_23545	COG3377	Domain of unknown function (DUF1805)
EXW58_23550	COG0737	Belongs to the 5'-nucleotidase family
EXW58_23560	COG0719	Fe-S assembly protein
EXW58_23565	COG0822	iron-sulfur transferase activity
EXW58_23570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW58_23575	COG0719	Fe-S assembly protein
EXW58_23580	COG0396	ATPase activity
EXW58_23585	COG1464	Belongs to the NlpA lipoprotein family
EXW58_23590	COG1464	Belongs to the NlpA lipoprotein family
EXW58_23595	COG2011	ABC-type metal ion transport system permease component
EXW58_23610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW58_23615	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW58_23620	COG0509	glycine decarboxylation via glycine cleavage system
EXW58_23625	COG1393	Belongs to the ArsC family
EXW58_23665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_23670	COG1960	acyl-CoA dehydrogenase activity
EXW58_23675	COG0183	Belongs to the thiolase family
EXW58_23680	COG1024	Enoyl-CoA hydratase
EXW58_23680	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW58_23690	COG1686	Belongs to the peptidase S11 family
EXW58_23695	COG0506	proline dehydrogenase activity
EXW58_23705	COG0011	TIGRFAM Protein of
EXW58_23710	COG0840	transmembrane signaling receptor activity
EXW58_23720	COG2814	Major facilitator Superfamily
EXW58_23725	COG0531	amino acid
EXW58_23755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW58_23790	COG0586	Pfam SNARE associated Golgi protein
EXW58_23800	COG1376	ErfK ybiS ycfS ynhG family protein
EXW58_23805	COG0745	RESPONSE REGULATOR receiver
EXW58_23810	COG5002	protein histidine kinase activity
EXW58_23825	COG0840	transmembrane signaling receptor activity
EXW58_23830	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW58_23835	COG3227	Zinc metalloprotease (Elastase)
EXW58_23855	COG0586	Pfam SNARE associated Golgi protein
EXW58_23860	COG0475	glutathione-regulated potassium exporter activity
EXW58_23865	COG0490	domain, Protein
EXW58_23870	COG1115	amino acid carrier protein
EXW58_23875	COG0783	Belongs to the Dps family
EXW58_23885	COG2318	DinB family
EXW58_23890	COG1611	Belongs to the LOG family
EXW58_23900	COG1528	Iron-storage protein
EXW58_23905	COG2311	Membrane
EXW58_23910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_23915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_23920	COG1115	amino acid carrier protein
EXW58_23925	COG2910	NAD(P)H-binding
EXW58_23935	COG0656	L-ascorbic acid biosynthetic process
EXW58_23940	COG2814	Major facilitator Superfamily
EXW58_23945	COG1733	regulation of RNA biosynthetic process
EXW58_23955	COG1252	NADH dehydrogenase
EXW58_24000	COG3655	Transcriptional regulator
EXW58_24015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW58_24040	COG1522	sequence-specific DNA binding
EXW58_24045	COG0288	reversible hydration of carbon dioxide
EXW58_24050	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW58_24055	COG2233	PERMEase
EXW58_24075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_24090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW58_24100	COG0557	exoribonuclease II activity
EXW58_24105	COG1647	Serine aminopeptidase, S33
EXW58_24110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW58_24115	COG1346	cytolysis
EXW58_24125	COG1957	nucleoside hydrolase
EXW58_24140	COG0149	triose-phosphate isomerase activity
EXW58_24145	COG0126	phosphoglycerate kinase activity
EXW58_24150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW58_24165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW58_24190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW58_24205	COG2323	membrane
EXW58_24215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW58_24220	COG1481	regulation of sporulation
EXW58_24225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW58_24230	COG1660	Displays ATPase and GTPase activities
EXW58_24235	COG1051	belongs to the nudix hydrolase family
EXW58_24245	COG0492	ferredoxin-NADP+ reductase activity
EXW58_24250	COG0457	Tetratricopeptide repeat
EXW58_24255	COG0110	maltose O-acetyltransferase activity
EXW58_24260	COG0546	phosphoglycolate phosphatase activity
EXW58_24265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW58_24270	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW58_24275	COG1950	PFAM Membrane protein of
EXW58_24280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW58_24295	COG0789	Transcriptional regulator
EXW58_24330	COG0583	DNA-binding transcription factor activity
EXW58_24335	COG0789	Transcriptional regulator
EXW58_24340	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW58_24345	COG0488	(ABC) transporter
EXW58_24355	COG1132	(ABC) transporter
EXW58_24360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW58_24365	COG0793	Belongs to the peptidase S41A family
EXW58_24365	COG3409	Peptidoglycan-binding domain 1 protein
EXW58_24370	COG2177	Part of the ABC transporter FtsEX involved in
EXW58_24375	COG2884	Cell division ATP-binding protein ftsE
EXW58_24415	COG1278	Cold shock
EXW58_24420	COG1040	competence protein
EXW58_24430	COG0791	NLP P60 protein
EXW58_24430	COG1388	LysM domain
EXW58_24435	COG1733	regulation of RNA biosynthetic process
EXW58_24440	COG1307	EDD domain protein, DegV family
EXW58_24445	COG1739	Uncharacterized protein family UPF0029
EXW58_24450	COG1316	TRANSCRIPTIONal
EXW58_24455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW58_24460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW58_24465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW58_24475	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW58_24475	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW58_24510	COG1486	melibiose metabolic process
EXW58_24515	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW58_24520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW58_24530	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW58_24545	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW58_24555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW58_24560	COG1301	dicarboxylic acid transport
EXW58_24575	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW58_24580	COG1271	oxidase subunit
EXW58_24585	COG1294	oxidase, subunit
EXW58_24590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW58_24600	COG1620	l-lactate permease
EXW58_24610	COG2389	metal-binding protein
EXW58_24625	COG1368	sulfuric ester hydrolase activity
EXW58_24640	COG0791	NLP P60 protein
EXW58_24640	COG1388	LysM domain
EXW58_24645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW58_24655	COG1215	transferase activity, transferring glycosyl groups
EXW58_24660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW58_24670	COG1388	LysM domain
EXW58_24670	COG3584	3D domain protein
EXW58_24690	COG4715	Zinc finger, swim domain protein
EXW58_24695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW58_24750	COG0577	efflux transmembrane transporter activity
EXW58_24755	COG1136	(ABC) transporter
EXW58_24780	COG5002	protein histidine kinase activity
EXW58_24780	COG3850	Histidine kinase
EXW58_24785	COG0745	RESPONSE REGULATOR receiver
EXW58_24790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW58_24800	COG1316	TRANSCRIPTIONal
EXW58_24805	COG3764	Sortase (surface protein transpeptidase)
EXW58_24840	COG0438	transferase activity, transferring glycosyl groups
EXW58_24855	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW58_24860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW58_24865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW58_24870	COG4464	protein tyrosine phosphatase activity
EXW58_24880	COG0489	protein tyrosine kinase activity
EXW58_24885	COG3944	biosynthesis protein
EXW58_24895	COG1132	(ABC) transporter
EXW58_24925	COG0367	asparagine synthase
EXW58_24930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW58_24940	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW58_24950	COG1216	Glycosyl transferase, family 2
EXW58_24985	COG1215	transferase activity, transferring glycosyl groups
EXW58_25005	COG0463	Glycosyl transferase, family 2
EXW58_25005	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW58_25015	COG0438	transferase activity, transferring glycosyl groups
EXW58_25020	COG0438	transferase activity, transferring glycosyl groups
EXW58_25025	COG1086	Polysaccharide biosynthesis protein
EXW58_25030	COG0489	protein tyrosine kinase activity
EXW58_25035	COG3944	biosynthesis protein
EXW58_25040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW58_25045	COG1134	teichoic acid transport
EXW58_25050	COG1682	transport, permease protein
EXW58_25055	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW58_25070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW58_25075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EXW58_25085	COG1609	Transcriptional regulator
EXW58_25095	COG0739	heme binding
EXW58_25110	COG3279	Response regulator of the LytR AlgR family
EXW58_25120	COG2385	sporulation resulting in formation of a cellular spore
EXW58_25135	COG4836	Membrane
EXW58_25140	COG1007	ATP synthesis coupled electron transport
EXW58_25145	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW58_25150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW58_25155	COG0713	ATP synthesis coupled electron transport
EXW58_25160	COG0839	Belongs to the complex I subunit 6 family
EXW58_25170	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW58_25175	COG0649	NAD binding
EXW58_25180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW58_25185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW58_25190	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW58_25195	COG5001	Diguanylate cyclase
EXW58_25195	COG3300	MHYT domain
EXW58_25210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW58_25215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW58_25220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW58_25225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW58_25235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW58_25245	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW58_25280	COG0698	ribose 5-phosphate isomerase
EXW58_25290	COG2190	(PTS) system
EXW58_25295	COG2259	Doxx family
EXW58_25300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW58_25310	COG1971	Probably functions as a manganese efflux pump
EXW58_25315	COG0009	L-threonylcarbamoyladenylate synthase
EXW58_25330	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW58_25335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW58_25340	COG1435	thymidine kinase activity
EXW58_25350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW58_25355	COG1494	fructose-1,6-bisphosphatase
EXW58_25375	COG4821	SIS domain
EXW58_25380	COG0504	CTP synthase activity
EXW58_25395	COG1960	acyl-CoA dehydrogenase activity
EXW58_25400	COG1960	acyl-CoA dehydrogenase activity
EXW58_25405	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW58_25410	COG0183	Belongs to the thiolase family
EXW58_25415	COG2181	nitrate reductase activity
EXW58_25415	COG0247	lactate metabolic process
EXW58_25420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW58_25425	COG4294	response to UV
EXW58_25430	COG5001	Diguanylate cyclase
EXW58_25430	COG3300	MHYT domain
EXW58_25450	COG3227	Zinc metalloprotease (Elastase)
EXW58_25455	COG2197	response regulator
EXW58_25460	COG4585	Histidine kinase
EXW58_25465	COG0842	Transport permease protein
EXW58_25470	COG1131	(ABC) transporter
EXW58_25475	COG0024	Methionine aminopeptidase
EXW58_25480	COG2234	aminopeptidase activity
EXW58_25495	COG4506	Protein conserved in bacteria
EXW58_25500	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW58_25525	COG2814	Major facilitator Superfamily
EXW58_25530	COG0789	Transcriptional regulator
EXW58_25535	COG0584	glycerophosphoryl diester phosphodiesterase
EXW58_25540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW58_25550	COG1994	Peptidase M50
EXW58_25560	COG1078	dGTPase activity
EXW58_25565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW58_25570	COG1120	ATPase activity
EXW58_25575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_25580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW58_25585	COG4844	belongs to the
EXW58_25605	COG0280	phosphate acetyltransferase
EXW58_25610	COG3253	May function as heme-dependent peroxidase
EXW58_25620	COG3773	Cell wall hydrolase
EXW58_25630	COG2363	Small membrane protein
EXW58_25640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW58_25645	COG2233	PERMEase
EXW58_25650	COG0561	phosphatase activity
EXW58_25655	COG2814	Major facilitator Superfamily
EXW58_25660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW58_25665	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW58_25670	COG1131	(ABC) transporter
EXW58_25675	COG2755	lipolytic protein G-D-S-L family
EXW58_25680	COG1609	Transcriptional regulator
EXW58_25690	COG0460	homoserine dehydrogenase
EXW58_25695	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW58_25700	COG2873	o-acetylhomoserine
EXW58_25715	COG2197	response regulator
EXW58_25720	COG2203	Gaf domain
EXW58_25720	COG4585	Histidine kinase
EXW58_25725	COG0351	phosphomethylpyrimidine kinase
EXW58_25730	COG3706	GGDEF domain
EXW58_25735	COG2879	small protein
EXW58_25740	COG1966	Carbon starvation protein
EXW58_25745	COG3279	Response regulator of the LytR AlgR family
EXW58_25750	COG0477	Major facilitator Superfamily
EXW58_25780	COG0840	transmembrane signaling receptor activity
EXW58_25790	COG1607	acyl-coa hydrolase
EXW58_25800	COG1216	Glycosyl transferase, family 2
EXW58_25805	COG0488	(ABC) transporter
EXW58_25820	COG1309	transcriptional regulator
EXW58_25825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW58_25830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW58_25830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW58_25845	COG0628	permease
EXW58_25855	COG1380	Effector of murein hydrolase LrgA
EXW58_25860	COG3279	Response regulator of the LytR AlgR family
EXW58_25865	COG3275	phosphorelay sensor kinase activity
EXW58_25870	COG2814	Major facilitator Superfamily
EXW58_25880	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW58_25910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW58_25915	COG1272	protein, Hemolysin III
EXW58_25940	COG1164	Oligoendopeptidase f
EXW58_25955	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW58_25965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW58_25970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW58_25975	COG4853	Protein conserved in bacteria
EXW58_25985	COG5002	protein histidine kinase activity
EXW58_25990	COG0745	RESPONSE REGULATOR receiver
EXW58_26020	COG0305	Participates in initiation and elongation during chromosome replication
EXW58_26030	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW58_26035	COG4241	membrane
EXW58_26045	COG0629	single-stranded DNA binding
EXW58_26050	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW58_26055	COG0012	GTP binding
EXW58_26060	COG4481	Protein conserved in bacteria
EXW58_26065	COG0668	transmembrane transport
EXW58_26075	COG1475	DNA binding
EXW58_26080	COG1192	Involved in chromosome partitioning
EXW58_26085	COG1475	DNA binding
EXW58_26095	COG0445	tRNA wobble uridine modification
EXW58_26100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW58_26105	COG1847	R3H domain protein
EXW58_26110	COG0706	membrane insertase activity
EXW58_26115	COG0594	ribonuclease P activity
EXW58_26120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW58_26230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW58_26275	COG0768	penicillin binding
EXW58_26325	COG2801	Transposase and inactivated derivatives
EXW58_26330	COG2801	Transposase and inactivated derivatives
EXW58_26435	COG2801	Transposase and inactivated derivatives
EXW58_26520	COG0659	secondary active sulfate transmembrane transporter activity
EXW58_26615	COG1278	Cold shock
EXW58_26725	COG1454	alcohol dehydrogenase
EXW58_26725	COG1012	belongs to the aldehyde dehydrogenase family
EXW58_26780	COG0302	gtp cyclohydrolase
EXW58_26790	COG0720	synthase
EXW58_26810	COG4555	ABC transporter
EXW58_26820	COG2226	methyltransferase
EXW58_26875	COG0697	spore germination
EXW58_26880	COG0814	amino acid
EXW58_26900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW58_26910	COG2707	UPF0756 membrane protein
EXW58_26915	COG0596	Alpha beta hydrolase
EXW58_26920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW58_27130	COG3655	Transcriptional regulator
EXW58_27140	COG4689	acetoacetate decarboxylase
EXW58_27145	COG0583	DNA-binding transcription factor activity
EXW58_27225	COG0791	NLP P60 protein
EXW58_27225	COG3883	PFAM NLP P60 protein
EXW58_27340	COG1192	Involved in chromosome partitioning
EXW58_27385	COG1278	Cold shock
EXW58_27435	COG3620	sequence-specific DNA binding
EXW58_27470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW58_27490	COG5002	protein histidine kinase activity
EXW58_27500	COG0745	RESPONSE REGULATOR receiver
EXW58_27525	COG4585	Histidine kinase
EXW58_27530	COG2197	response regulator
EXW58_27545	COG2801	Transposase and inactivated derivatives
EXW58_27555	COG0596	Alpha beta hydrolase
EXW58_27560	COG1073	alpha beta
EXW58_27675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW58_27685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW58_27710	COG2002	toxin-antitoxin pair type II binding
EXW58_27815	COG1674	ftsk spoiiie
EXW58_27825	COG0741	lytic transglycosylase activity
EXW58_27835	COG5002	protein histidine kinase activity
EXW58_27840	COG0745	RESPONSE REGULATOR receiver
EXW58_27845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW58_27850	COG0577	efflux transmembrane transporter activity
EXW58_27855	COG1136	(ABC) transporter
EXW58_27890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW58_27915	COG0494	nUDIX hydrolase
EXW58_27955	COG1183	phosphatidylcholine synthase activity
EXW58_28075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW58_28100	COG2031	fatty acid transporter
EXW58_28110	COG2312	Erythromycin esterase
EXW58_28135	COG1028	Short-chain dehydrogenase reductase Sdr
EXW58_28160	COG2070	2-Nitropropane dioxygenase
EXW58_28185	COG0582	viral genome integration into host DNA
EXW58_28190	COG2801	Transposase and inactivated derivatives
EXW58_28260	COG2318	DinB family
EXW58_28310	COG1760	l-serine dehydratase
EXW58_28315	COG1760	l-serine dehydratase
EXW58_28320	COG0814	amino acid
EXW58_28330	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW58_28355	COG0714	Associated with various cellular activities
EXW58_28365	COG3552	Protein containing von Willebrand factor type A (VWA) domain
EXW58_28400	COG0737	Belongs to the 5'-nucleotidase family
EXW58_28405	COG4974	Belongs to the 'phage' integrase family
EXW58_28510	COG1923	regulation of RNA biosynthetic process
EXW58_28535	COG0443	Heat shock 70 kDa protein
EXW58_28540	COG0457	Tetratricopeptide repeat
EXW58_28690	COG5444	nuclease activity
EXW58_28750	COG1674	ftsk spoiiie
EXW58_28755	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW58_28775	COG4842	Belongs to the WXG100 family
EXW58_28870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW58_28870	COG2755	lipolytic protein G-D-S-L family
EXW58_28905	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW58_28905	COG3409	Peptidoglycan-binding domain 1 protein
EXW58_28920	COG0582	viral genome integration into host DNA
EXW58_28985	COG2002	toxin-antitoxin pair type II binding
EXW58_29005	COG3227	Zinc metalloprotease (Elastase)
EXW58_29015	COG0577	efflux transmembrane transporter activity
EXW58_29020	COG1136	(ABC) transporter
EXW58_29060	COG2002	toxin-antitoxin pair type II binding
EXW58_29120	COG2186	Transcriptional regulator
EXW58_29160	COG0662	Cupin 2, conserved barrel domain protein