locus-tag	class	description
EXW35_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW35_00010	COG0592	DNA-directed DNA polymerase activity
EXW35_00015	COG2501	S4 domain
EXW35_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW35_00025	COG0187	DNA topoisomerase II activity
EXW35_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW35_00065	COG0516	GMP reductase activity
EXW35_00065	COG0517	IMP dehydrogenase activity
EXW35_00070	COG1686	Belongs to the peptidase S11 family
EXW35_00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW35_00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW35_00100	COG1428	Deoxynucleoside kinase
EXW35_00105	COG1428	Deoxynucleoside kinase
EXW35_00110	COG1335	isochorismatase
EXW35_00115	COG0590	tRNA wobble adenosine to inosine editing
EXW35_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW35_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW35_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW35_00180	COG1982	Orn Lys Arg decarboxylase major
EXW35_00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW35_00190	COG0470	DNA polymerase III
EXW35_00195	COG1774	PSP1 C-terminal conserved region
EXW35_00200	COG4467	Involved in initiation control of chromosome replication
EXW35_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW35_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW35_00220	COG2002	toxin-antitoxin pair type II binding
EXW35_00230	COG0084	hydrolase, TatD family'
EXW35_00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW35_00250	COG4466	Protein conserved in bacteria
EXW35_00260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW35_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW35_00270	COG0251	oxidation-reduction process
EXW35_00275	COG2088	sporulation resulting in formation of a cellular spore
EXW35_00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW35_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW35_00305	COG2002	toxin-antitoxin pair type II binding
EXW35_00310	COG2244	polysaccharide biosynthetic process
EXW35_00315	COG3956	TIGRFAM MazG family protein
EXW35_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW35_00340	COG1098	S1 RNA binding domain
EXW35_00355	COG2208	phosphoserine phosphatase activity
EXW35_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW35_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW35_00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW35_00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW35_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW35_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW35_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW35_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW35_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW35_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW35_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW35_00420	COG1396	sequence-specific DNA binding
EXW35_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW35_00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW35_00515	COG3880	PFAM UvrB UvrC protein
EXW35_00520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW35_00525	COG0542	response to heat
EXW35_00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW35_00535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW35_00540	COG4956	integral membrane protein (PIN domain superfamily)
EXW35_00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW35_00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW35_00560	COG1045	serine acetyltransferase
EXW35_00565	COG0215	cysteine-tRNA ligase activity
EXW35_00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW35_00580	COG3688	RNA-binding protein containing a PIN domain
EXW35_00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW35_00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW35_00600	COG0250	Participates in transcription elongation, termination and antitermination
EXW35_00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW35_00610	COG0081	regulation of translation
EXW35_00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW35_00620	COG0222	ribosome binding
EXW35_00625	COG2813	Specifically methylates the guanine in position
EXW35_00630	COG0085	RNA polymerase activity
EXW35_00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW35_00640	COG1358	cellular component organization or biogenesis
EXW35_00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW35_00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW35_00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW35_00665	COG0051	transcription antitermination factor activity, RNA binding
EXW35_00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW35_00675	COG0088	Forms part of the polypeptide exit tunnel
EXW35_00680	COG0089	rRNA binding
EXW35_00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW35_00690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW35_00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW35_00710	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW35_00715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW35_00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW35_00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW35_00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW35_00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW35_00760	COG1841	ribosomal large subunit assembly
EXW35_00765	COG0200	Binds to the 23S rRNA
EXW35_00770	COG0201	protein transport
EXW35_00775	COG0563	adenylate kinase activity
EXW35_00780	COG0024	Methionine aminopeptidase
EXW35_00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW35_00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW35_00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW35_00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW35_00835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW35_00840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW35_00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW35_00855	COG0489	protein tyrosine kinase activity
EXW35_00865	COG2194	sulfuric ester hydrolase activity
EXW35_00870	COG0726	polysaccharide deacetylase
EXW35_00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW35_00955	COG4856	YbbR-like protein
EXW35_00960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW35_00990	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_00995	COG2011	ABC-type metal ion transport system permease component
EXW35_01005	COG1464	Belongs to the NlpA lipoprotein family
EXW35_01010	COG0604	alcohol dehydrogenase
EXW35_01020	COG0277	FAD linked oxidase domain protein
EXW35_01025	COG2271	Major facilitator Superfamily
EXW35_01035	COG2814	Major facilitator Superfamily
EXW35_01050	COG0601	transmembrane transport
EXW35_01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW35_01060	COG0444	Belongs to the ABC transporter superfamily
EXW35_01065	COG4608	Belongs to the ABC transporter superfamily
EXW35_01070	COG4166	transmembrane transport
EXW35_01080	COG2207	Transcriptional regulator
EXW35_01095	COG4166	transmembrane transport
EXW35_01100	COG4166	transmembrane transport
EXW35_01105	COG0656	L-ascorbic acid biosynthetic process
EXW35_01110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW35_01125	COG4149	molybdate abc transporter
EXW35_01130	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW35_01135	COG1910	domain protein
EXW35_01155	COG0697	spore germination
EXW35_01170	COG0204	Acyl-transferase
EXW35_01180	COG1609	Transcriptional regulator
EXW35_01190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW35_01205	COG5298	Protein conserved in bacteria
EXW35_01230	COG0488	(ABC) transporter
EXW35_01235	COG4585	Histidine kinase
EXW35_01240	COG2197	response regulator
EXW35_01245	COG1131	(ABC) transporter
EXW35_01250	COG0842	Transport permease protein
EXW35_01250	COG1511	domain protein
EXW35_01255	COG0842	Transport permease protein
EXW35_01265	COG0747	negative chemotaxis
EXW35_01275	COG0601	transmembrane transport
EXW35_01280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW35_01285	COG0444	Belongs to the ABC transporter superfamily
EXW35_01290	COG4608	Belongs to the ABC transporter superfamily
EXW35_01295	COG0561	phosphatase activity
EXW35_01325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW35_01330	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW35_01340	COG0531	amino acid
EXW35_01345	COG2814	Major facilitator Superfamily
EXW35_01355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW35_01365	COG4294	response to UV
EXW35_01370	COG0705	Rhomboid family
EXW35_01375	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW35_01380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW35_01390	COG0864	Transcriptional regulator
EXW35_01395	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW35_01400	COG2183	response to ionizing radiation
EXW35_01500	COG0802	atpase or kinase
EXW35_01505	COG1214	PFAM Peptidase M22, glycoprotease
EXW35_01510	COG0456	acetyltransferase
EXW35_01520	COG0488	(ABC) transporter
EXW35_01525	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW35_01535	COG1266	CAAX protease self-immunity
EXW35_01540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW35_01545	COG0459	protein refolding
EXW35_01550	COG0519	Catalyzes the synthesis of GMP from XMP
EXW35_01550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW35_01555	COG2252	PERMEase
EXW35_01565	COG5002	protein histidine kinase activity
EXW35_01590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW35_01655	COG2205	protein histidine kinase activity
EXW35_01660	COG0745	RESPONSE REGULATOR receiver
EXW35_01685	COG0697	spore germination
EXW35_01715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW35_01720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW35_01725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW35_01730	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW35_01735	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW35_01740	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW35_01745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW35_01750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW35_01755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW35_01760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW35_01765	COG0138	bifunctional purine biosynthesis protein purh
EXW35_01770	COG0151	Belongs to the GarS family
EXW35_01795	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW35_01800	COG0210	DNA helicase
EXW35_01805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW35_01810	COG4851	CamS sex pheromone cAM373 precursor
EXW35_01820	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_01825	COG1335	isochorismatase
EXW35_01835	COG2011	ABC-type metal ion transport system permease component
EXW35_01840	COG1464	Belongs to the NlpA lipoprotein family
EXW35_01855	COG0003	Pfam Anion-transporting ATPase
EXW35_01860	COG1846	Transcriptional regulator
EXW35_01865	COG4682	membrane
EXW35_01875	COG0154	amidase activity
EXW35_01880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW35_01885	COG1597	lipid kinase activity
EXW35_01890	COG0546	phosphoglycolate phosphatase activity
EXW35_01895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW35_01905	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_01910	COG2076	Multidrug Resistance protein
EXW35_01915	COG2309	aminopeptidase activity
EXW35_01930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW35_01940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW35_01945	COG5002	protein histidine kinase activity
EXW35_01950	COG4807	Protein conserved in bacteria
EXW35_01975	COG1757	Na H antiporter
EXW35_01980	COG1473	amidohydrolase
EXW35_02000	COG0450	alkyl hydroperoxide reductase
EXW35_02010	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW35_02020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW35_02025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW35_02030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW35_02040	COG0492	ferredoxin-NADP+ reductase activity
EXW35_02055	COG0166	Belongs to the GPI family
EXW35_02080	COG5002	protein histidine kinase activity
EXW35_02100	COG3541	Predicted nucleotidyltransferase
EXW35_02105	COG2814	Major facilitator Superfamily
EXW35_02110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW35_02110	COG0723	plastoquinol--plastocyanin reductase activity
EXW35_02120	COG0765	amino acid transport
EXW35_02125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW35_02135	COG0840	transmembrane signaling receptor activity
EXW35_02140	COG0277	FAD linked oxidase domain protein
EXW35_02145	COG0366	Alpha amylase catalytic
EXW35_02150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW35_02150	COG1263	PTS System
EXW35_02150	COG2190	(PTS) system
EXW35_02170	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW35_02175	COG0352	thiamine-phosphate diphosphorylase activity
EXW35_02180	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW35_02195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW35_02200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW35_02205	COG1116	anion transmembrane transporter activity
EXW35_02210	COG0488	(ABC) transporter
EXW35_02255	COG2270	Major facilitator Superfamily
EXW35_02285	COG2310	stress, protein
EXW35_02290	COG2310	stress, protein
EXW35_02295	COG2310	stress, protein
EXW35_02300	COG0861	Integral membrane protein TerC family
EXW35_02310	COG3853	Toxic anion resistance protein (TelA)
EXW35_02320	COG4840	Belongs to the UPF0435 family
EXW35_02325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW35_02335	COG1295	ribonuclease BN
EXW35_02340	COG2217	Heavy metal translocating P-type atpase
EXW35_02345	COG0697	spore germination
EXW35_02370	COG0586	Pfam SNARE associated Golgi protein
EXW35_02385	COG3871	stress protein (general stress protein 26)
EXW35_02390	COG0387	Pfam Sodium calcium exchanger
EXW35_02400	COG0535	radical SAM domain protein
EXW35_02420	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW35_02440	COG3829	transcription factor binding
EXW35_02450	COG0833	amino acid
EXW35_02455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW35_02475	COG2066	Belongs to the glutaminase family
EXW35_02485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW35_02485	COG1263	PTS System
EXW35_02490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW35_02505	COG1216	Glycosyl transferase, family 2
EXW35_02515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW35_02515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW35_02520	COG0463	Glycosyl transferase, family 2
EXW35_02535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW35_02540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW35_02555	COG1228	amidohydrolase
EXW35_02560	COG1090	epimerase
EXW35_02565	COG2137	regulation of response to DNA damage stimulus
EXW35_02590	COG1988	membrane-bound metal-dependent
EXW35_02595	COG1194	a g-specific adenine glycosylase
EXW35_02610	COG3557	Belongs to the UPF0374 family
EXW35_02615	COG1132	(ABC) transporter
EXW35_02620	COG4129	membrane
EXW35_02630	COG0070	glutamate synthase
EXW35_02630	COG0069	glutamate synthase activity
EXW35_02630	COG0067	glutamate synthase
EXW35_02635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW35_02640	COG4555	ABC transporter
EXW35_02660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW35_02665	COG0735	belongs to the Fur family
EXW35_02785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW35_02790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW35_02810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW35_02820	COG2766	serine protein kinase
EXW35_02825	COG2718	Belongs to the UPF0229 family
EXW35_02910	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW35_02915	COG2268	Band 7 protein
EXW35_02925	COG3290	protein histidine kinase activity
EXW35_02930	COG4565	transcriptional regulatory protein
EXW35_02935	COG2851	Citrate transporter
EXW35_02960	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW35_02965	COG3842	ATPase activity
EXW35_02970	COG1175	transmembrane transport
EXW35_02975	COG0395	ABC-type sugar transport system, permease component
EXW35_02985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW35_02990	COG0745	RESPONSE REGULATOR receiver
EXW35_02995	COG5002	protein histidine kinase activity
EXW35_03005	COG4990	cell redox homeostasis
EXW35_03015	COG3290	protein histidine kinase activity
EXW35_03020	COG4565	transcriptional regulatory protein
EXW35_03025	COG3493	citrate carrier protein
EXW35_03030	COG0281	malic enzyme
EXW35_03040	COG0697	spore germination
EXW35_03045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW35_03055	COG5002	protein histidine kinase activity
EXW35_03060	COG0745	RESPONSE REGULATOR receiver
EXW35_03065	COG0456	acetyltransferase
EXW35_03070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW35_03075	COG3383	formate dehydrogenase (NAD+) activity
EXW35_03080	COG2427	Protein of unknown function (DUF1641)
EXW35_03095	COG0531	amino acid
EXW35_03105	COG0640	Transcriptional regulator
EXW35_03110	COG2217	Heavy metal translocating P-type atpase
EXW35_03115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW35_03125	COG3227	Zinc metalloprotease (Elastase)
EXW35_03145	COG2720	vancomycin resistance protein
EXW35_03150	COG1316	TRANSCRIPTIONal
EXW35_03155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW35_03160	COG0346	lactoylglutathione lyase activity
EXW35_03165	COG1253	flavin adenine dinucleotide binding
EXW35_03170	COG1027	Aspartate ammonia-lyase
EXW35_03175	COG1620	l-lactate permease
EXW35_03180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW35_03200	COG3104	oligopeptide transport
EXW35_03205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW35_03210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW35_03215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW35_03230	COG0156	8-amino-7-oxononanoate synthase activity
EXW35_03235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW35_03245	COG4548	von Willebrand factor, type A
EXW35_03250	COG0714	Associated with various cellular activities
EXW35_03270	COG0531	amino acid
EXW35_03275	COG2188	Transcriptional regulator
EXW35_03280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW35_03280	COG1263	PTS System
EXW35_03285	COG0366	Alpha amylase catalytic
EXW35_03300	COG0697	spore germination
EXW35_03305	COG4585	Histidine kinase
EXW35_03310	COG2197	response regulator
EXW35_03315	COG1404	Belongs to the peptidase S8 family
EXW35_03330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW35_03335	COG1115	amino acid carrier protein
EXW35_03340	COG1126	abc transporter atp-binding protein
EXW35_03345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW35_03350	COG0765	amino acid transport
EXW35_03355	COG0765	amino acid transport
EXW35_03360	COG0833	amino acid
EXW35_03385	COG2378	regulation of single-species biofilm formation
EXW35_03390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW35_03395	COG5002	protein histidine kinase activity
EXW35_03410	COG0659	secondary active sulfate transmembrane transporter activity
EXW35_03425	COG2271	Major facilitator Superfamily
EXW35_03430	COG1846	Transcriptional regulator
EXW35_03435	COG0477	Major facilitator Superfamily
EXW35_03440	COG1609	Transcriptional regulator
EXW35_03445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW35_03450	COG1869	D-ribose catabolic process
EXW35_03460	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW35_03465	COG1879	ABC-type sugar transport system periplasmic component
EXW35_03495	COG1063	alcohol dehydrogenase
EXW35_03510	COG3568	Endonuclease Exonuclease Phosphatase
EXW35_03540	COG0840	transmembrane signaling receptor activity
EXW35_03545	COG1388	LysM domain
EXW35_03545	COG3584	3D domain protein
EXW35_03550	COG1476	TRANSCRIPTIONal
EXW35_03570	COG3104	oligopeptide transport
EXW35_03575	COG1114	Component of the transport system for branched-chain amino acids
EXW35_03590	COG1113	amino acid transport
EXW35_03595	COG2252	PERMEase
EXW35_03610	COG2153	protein acetylation
EXW35_03620	COG0569	domain protein
EXW35_03620	COG0475	glutathione-regulated potassium exporter activity
EXW35_03635	COG1845	cytochrome c oxidase, subunit III
EXW35_03640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW35_03650	COG0833	amino acid
EXW35_03655	COG4990	cell redox homeostasis
EXW35_03670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW35_03675	COG0697	spore germination
EXW35_03680	COG0531	amino acid
EXW35_03690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW35_03695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW35_03705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW35_03710	COG0573	inorganic phosphate transmembrane transporter activity
EXW35_03715	COG0581	inorganic phosphate transmembrane transporter activity
EXW35_03725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW35_03845	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW35_03860	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW35_03860	COG4991	sh3 domain protein
EXW35_03860	COG3103	Sh3 type 3 domain protein
EXW35_03865	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW35_03870	COG1116	anion transmembrane transporter activity
EXW35_03875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW35_03880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW35_03885	COG0352	thiamine-phosphate diphosphorylase activity
EXW35_03890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW35_03895	COG2104	thiamine diphosphate biosynthetic process
EXW35_03900	COG2022	thiamine diphosphate biosynthetic process
EXW35_03905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW35_03910	COG0351	phosphomethylpyrimidine kinase
EXW35_03935	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXW35_03940	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW35_03945	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW35_03950	COG2205	protein histidine kinase activity
EXW35_03955	COG2814	Major facilitator Superfamily
EXW35_03960	COG1846	Transcriptional regulator
EXW35_03980	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW35_03985	COG1129	ABC transporter
EXW35_03990	COG1879	ABC-type sugar transport system periplasmic component
EXW35_03995	COG2252	PERMEase
EXW35_04000	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_04015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW35_04020	COG1621	beta-fructofuranosidase activity
EXW35_04025	COG1263	PTS System
EXW35_04025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW35_04030	COG1609	Transcriptional regulator
EXW35_04080	COG0778	Nitroreductase
EXW35_04085	COG2719	SpoVR family
EXW35_04110	COG1937	Protein conserved in bacteria
EXW35_04115	COG0425	Belongs to the sulfur carrier protein TusA family
EXW35_04115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW35_04120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW35_04120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW35_04125	COG0425	Belongs to the sulfur carrier protein TusA family
EXW35_04130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW35_04130	COG0425	Belongs to the sulfur carrier protein TusA family
EXW35_04135	COG2210	Belongs to the sulfur carrier protein TusA family
EXW35_04140	COG0730	response to heat
EXW35_04150	COG1316	TRANSCRIPTIONal
EXW35_04155	COG0604	alcohol dehydrogenase
EXW35_04160	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW35_04165	COG0604	alcohol dehydrogenase
EXW35_04170	COG2814	Major facilitator Superfamily
EXW35_04185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW35_04185	COG3711	transcriptional antiterminator
EXW35_04190	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW35_04195	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW35_04220	COG1388	LysM domain
EXW35_04220	COG3584	3D domain protein
EXW35_04225	COG0577	efflux transmembrane transporter activity
EXW35_04230	COG1136	(ABC) transporter
EXW35_04240	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW35_04255	COG1114	Component of the transport system for branched-chain amino acids
EXW35_04260	COG3546	catalase activity
EXW35_04290	COG0586	Pfam SNARE associated Golgi protein
EXW35_04325	COG0531	amino acid
EXW35_04330	COG0475	glutathione-regulated potassium exporter activity
EXW35_04340	COG1737	Transcriptional regulator
EXW35_04345	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW35_04350	COG1263	PTS System
EXW35_04350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW35_04360	COG2259	Doxx family
EXW35_04380	COG0697	spore germination
EXW35_04385	COG1522	sequence-specific DNA binding
EXW35_04395	COG0300	oxidoreductase activity
EXW35_04410	COG2076	Multidrug Resistance protein
EXW35_04415	COG1309	transcriptional regulator
EXW35_04420	COG2814	Major facilitator Superfamily
EXW35_04425	COG1733	regulation of RNA biosynthetic process
EXW35_04440	COG4533	DNA binding
EXW35_04445	COG2211	Major facilitator Superfamily
EXW35_04455	COG0693	protein deglycase activity
EXW35_04465	COG0531	amino acid
EXW35_04470	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_04485	COG1132	(ABC) transporter
EXW35_04490	COG1132	(ABC) transporter
EXW35_04495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW35_04500	COG0765	amino acid transport
EXW35_04505	COG1126	abc transporter atp-binding protein
EXW35_04520	COG0189	ligase activity
EXW35_04530	COG4399	Belongs to the UPF0754 family
EXW35_04535	COG3679	Belongs to the UPF0342 family
EXW35_04550	COG0028	Belongs to the TPP enzyme family
EXW35_04555	COG3527	Alpha-acetolactate decarboxylase
EXW35_04560	COG0463	Glycosyl transferase, family 2
EXW35_04565	COG1216	Glycosyl transferase, family 2
EXW35_04570	COG2094	Belongs to the DNA glycosylase MPG family
EXW35_04575	COG0561	phosphatase activity
EXW35_04585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW35_04590	COG0318	PFAM AMP-dependent synthetase and ligase
EXW35_04600	COG0659	secondary active sulfate transmembrane transporter activity
EXW35_04610	COG2244	polysaccharide biosynthetic process
EXW35_04630	COG1696	Membrane protein involved in D-alanine export
EXW35_04645	COG1024	Enoyl-CoA hydratase
EXW35_04660	COG1363	Peptidase, m42
EXW35_04675	COG2318	DinB family
EXW35_04695	COG0579	oxidoreductase
EXW35_04730	COG0601	transmembrane transport
EXW35_04735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW35_04740	COG0444	Belongs to the ABC transporter superfamily
EXW35_04745	COG4608	Belongs to the ABC transporter superfamily
EXW35_04800	COG5444	nuclease activity
EXW35_04860	COG0477	Major facilitator Superfamily
EXW35_04865	COG3290	protein histidine kinase activity
EXW35_04870	COG4565	transcriptional regulatory protein
EXW35_04875	COG3181	Tripartite tricarboxylate transporter family receptor
EXW35_04890	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EXW35_04930	COG0305	Participates in initiation and elongation during chromosome replication
EXW35_04960	COG0477	Major facilitator Superfamily
EXW35_04995	COG3711	transcriptional antiterminator
EXW35_05000	COG2190	(PTS) system
EXW35_05000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW35_05000	COG1263	PTS System
EXW35_05005	COG2723	6-phospho-beta-galactosidase activity
EXW35_05010	COG0456	acetyltransferase
EXW35_05020	COG1183	phosphatidylcholine synthase activity
EXW35_05090	COG2814	Major facilitator Superfamily
EXW35_05095	COG0640	Transcriptional regulator
EXW35_05120	COG2376	Dihydroxyacetone kinase
EXW35_05135	COG2376	Dihydroxyacetone kinase
EXW35_05150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW35_05185	COG0076	glutamate decarboxylase activity
EXW35_05210	COG0737	Belongs to the 5'-nucleotidase family
EXW35_05210	COG1525	nuclease
EXW35_05210	COG4085	toxin activity
EXW35_05250	COG3237	CsbD-like
EXW35_05270	COG2172	sigma factor antagonist activity
EXW35_05275	COG1191	sigma factor activity
EXW35_05285	COG2208	phosphoserine phosphatase activity
EXW35_05290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW35_05295	COG2205	protein histidine kinase activity
EXW35_05295	COG2198	Histidine kinase
EXW35_05295	COG0784	Response regulator, receiver
EXW35_05335	COG2807	transmembrane transport
EXW35_05340	COG2186	Transcriptional regulator
EXW35_05345	COG4585	Histidine kinase
EXW35_05350	COG2197	response regulator
EXW35_05380	COG0420	3'-5' exonuclease activity
EXW35_05385	COG4717	serine-type aminopeptidase activity
EXW35_05390	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW35_05400	COG0346	lactoylglutathione lyase activity
EXW35_05405	COG0346	lactoylglutathione lyase activity
EXW35_05410	COG0457	Tetratricopeptide repeat
EXW35_05420	COG2267	carboxylic ester hydrolase activity
EXW35_05430	COG2140	Oxalate decarboxylase
EXW35_05435	COG3620	sequence-specific DNA binding
EXW35_05440	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW35_05445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW35_05450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW35_05455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW35_05460	COG1595	DNA-templated transcription, initiation
EXW35_05475	COG3973	AAA domain
EXW35_05480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW35_05495	COG1846	Transcriptional regulator
EXW35_05505	COG0537	adenosine 5'-monophosphoramidase activity
EXW35_05510	COG1131	(ABC) transporter
EXW35_05515	COG4473	ABC transporter
EXW35_05525	COG0247	lactate metabolic process
EXW35_05530	COG1139	Iron-sulfur cluster binding protein
EXW35_05535	COG1556	Lactate utilization protein
EXW35_05550	COG3402	PFAM membrane-flanked domain
EXW35_05555	COG3428	Bacterial PH domain
EXW35_05595	COG3402	PFAM membrane-flanked domain
EXW35_05600	COG3428	Bacterial PH domain
EXW35_05605	COG2329	Antibiotic biosynthesis monooxygenase
EXW35_05610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW35_05615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW35_05620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW35_05625	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW35_05655	COG1309	transcriptional regulator
EXW35_05660	COG1511	domain protein
EXW35_05695	COG2378	regulation of single-species biofilm formation
EXW35_05700	COG1609	Transcriptional regulator
EXW35_05710	COG1234	tRNA 3'-trailer cleavage
EXW35_05715	COG0095	Lipoate-protein ligase
EXW35_05725	COG0318	PFAM AMP-dependent synthetase and ligase
EXW35_05740	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW35_05745	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EXW35_05750	COG4208	sulfate ABC transporter
EXW35_05765	COG1408	metallophosphoesterase
EXW35_05770	COG1078	dGTPase activity
EXW35_05785	COG1595	DNA-templated transcription, initiation
EXW35_05795	COG3708	Transcriptional regulator
EXW35_05795	COG2207	Transcriptional regulator
EXW35_05800	COG2205	protein histidine kinase activity
EXW35_05805	COG0745	RESPONSE REGULATOR receiver
EXW35_05825	COG0501	Belongs to the peptidase M48B family
EXW35_05830	COG0697	spore germination
EXW35_05860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW35_05865	COG2224	Isocitrate lyase
EXW35_05875	COG1278	Cold shock
EXW35_05895	COG4903	ComK protein
EXW35_05900	COG0398	Pfam SNARE associated Golgi protein
EXW35_05910	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW35_05915	COG1074	ATP-dependent DNA helicase activity
EXW35_05965	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW35_05990	COG0367	asparagine synthase
EXW35_06000	COG0753	catalase activity
EXW35_06005	COG0004	ammonium transporteR
EXW35_06015	COG1666	GTP binding
EXW35_06020	COG2996	Protein conserved in bacteria
EXW35_06025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW35_06035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW35_06050	COG0561	phosphatase activity
EXW35_06070	COG2267	carboxylic ester hydrolase activity
EXW35_06085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW35_06090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW35_06095	COG5504	Zn-dependent protease
EXW35_06105	COG0180	Tryptophanyl-tRNA synthetase
EXW35_06120	COG4166	transmembrane transport
EXW35_06125	COG0601	transmembrane transport
EXW35_06130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW35_06135	COG0444	Belongs to the ABC transporter superfamily
EXW35_06140	COG4608	Belongs to the ABC transporter superfamily
EXW35_06145	COG0534	Mate efflux family protein
EXW35_06150	COG4166	transmembrane transport
EXW35_06170	COG0861	Integral membrane protein TerC family
EXW35_06175	COG4862	establishment of competence for transformation
EXW35_06180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW35_06190	COG1164	Oligoendopeptidase f
EXW35_06200	COG2346	COG2346, Truncated hemoglobins
EXW35_06205	COG4116	CYTH
EXW35_06215	COG2357	RelA SpoT domain protein
EXW35_06225	COG0564	pseudouridine synthase activity
EXW35_06235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW35_06240	COG0772	Belongs to the SEDS family
EXW35_06245	COG1216	Glycosyl transferase, family 2
EXW35_06265	COG0457	Tetratricopeptide repeat
EXW35_06265	COG0463	Glycosyl transferase, family 2
EXW35_06285	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW35_06300	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW35_06345	COG2153	protein acetylation
EXW35_06350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW35_06355	COG2382	esterase
EXW35_06380	COG5492	domain, Protein
EXW35_06385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW35_06400	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW35_06400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW35_06405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW35_06410	COG0134	indole-3-glycerol-phosphate synthase activity
EXW35_06415	COG0135	phosphoribosylanthranilate isomerase activity
EXW35_06420	COG0133	tryptophan synthase activity
EXW35_06425	COG0159	tryptophan synthase activity
EXW35_06435	COG1620	l-lactate permease
EXW35_06440	COG5634	Uncharacterized conserved protein (DUF2278)
EXW35_06475	COG2226	methyltransferase
EXW35_06495	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW35_06500	COG0567	Dehydrogenase, E1 component
EXW35_06505	COG1476	TRANSCRIPTIONal
EXW35_06530	COG4152	abc transporter atp-binding protein
EXW35_06535	COG1668	transmembrane transport
EXW35_06550	COG1396	sequence-specific DNA binding
EXW35_06625	COG1686	Belongs to the peptidase S11 family
EXW35_06630	COG0681	Belongs to the peptidase S26 family
EXW35_06665	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_06675	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW35_06680	COG1177	transmembrane transport
EXW35_06685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW35_06695	COG2409	Drug exporters of the RND superfamily
EXW35_06705	COG0564	pseudouridine synthase activity
EXW35_06715	COG2340	Cysteine-rich secretory protein family
EXW35_06720	COG0247	lactate metabolic process
EXW35_06725	COG0277	FAD linked oxidase domain protein
EXW35_06730	COG3835	regulator
EXW35_06740	COG0745	RESPONSE REGULATOR receiver
EXW35_06745	COG5002	protein histidine kinase activity
EXW35_06750	COG2186	Transcriptional regulator
EXW35_06755	COG0247	lactate metabolic process
EXW35_06760	COG1139	Iron-sulfur cluster binding protein
EXW35_06765	COG1556	Lactate utilization protein
EXW35_06770	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW35_06780	COG2116	formate transmembrane transporter activity
EXW35_06785	COG0861	Integral membrane protein TerC family
EXW35_06790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW35_06800	COG2030	dehydratase
EXW35_06820	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_06825	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW35_06835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW35_06850	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW35_06855	COG3842	ATPase activity
EXW35_06865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW35_06870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW35_06880	COG1349	DNA-binding transcription factor activity
EXW35_06890	COG0235	Class ii aldolase
EXW35_06900	COG2861	carbohydrate metabolic process
EXW35_06910	COG3852	Histidine kinase
EXW35_06915	COG1846	Transcriptional regulator
EXW35_06925	COG2318	DinB family
EXW35_06930	COG5002	protein histidine kinase activity
EXW35_06935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW35_06940	COG0720	synthase
EXW35_06950	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW35_06955	COG4873	Protein conserved in bacteria
EXW35_06965	COG0456	acetyltransferase
EXW35_06985	COG1780	Probably involved in ribonucleotide reductase function
EXW35_07000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW35_07005	COG0531	amino acid
EXW35_07010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW35_07025	COG2204	response regulator
EXW35_07030	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_07040	COG1725	Transcriptional regulator
EXW35_07045	COG1131	(ABC) transporter
EXW35_07055	COG1131	(ABC) transporter
EXW35_07060	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW35_07065	COG1266	CAAX protease self-immunity
EXW35_07075	COG1522	sequence-specific DNA binding
EXW35_07085	COG1335	isochorismatase
EXW35_07095	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW35_07100	COG2070	2-Nitropropane dioxygenase
EXW35_07105	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW35_07110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW35_07115	COG1696	Membrane protein involved in D-alanine export
EXW35_07135	COG0716	FMN binding
EXW35_07160	COG0534	Mate efflux family protein
EXW35_07165	COG1968	undecaprenyl-diphosphatase activity
EXW35_07185	COG1846	Transcriptional regulator
EXW35_07195	COG1301	dicarboxylic acid transport
EXW35_07200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW35_07210	COG3874	Sporulation protein YtfJ
EXW35_07235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW35_07240	COG0028	Belongs to the TPP enzyme family
EXW35_07245	COG0440	acetolactate synthase activity
EXW35_07255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW35_07265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW35_07275	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW35_07280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW35_07290	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW35_07295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW35_07300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW35_07305	COG0107	imidazoleglycerol-phosphate synthase activity
EXW35_07315	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW35_07320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW35_07335	COG1183	phosphatidylcholine synthase activity
EXW35_07340	COG1368	sulfuric ester hydrolase activity
EXW35_07350	COG0019	diaminopimelate decarboxylase activity
EXW35_07360	COG0175	sulfate reduction
EXW35_07365	COG2046	Belongs to the sulfate adenylyltransferase family
EXW35_07370	COG0529	Catalyzes the synthesis of activated sulfate
EXW35_07375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW35_07395	COG1648	precorrin-2 dehydrogenase activity
EXW35_07405	COG0733	neurotransmitter:sodium symporter activity
EXW35_07425	COG1757	Na H antiporter
EXW35_07440	COG4758	membrane
EXW35_07445	COG4585	Histidine kinase
EXW35_07450	COG2197	response regulator
EXW35_07460	COG1114	Component of the transport system for branched-chain amino acids
EXW35_07470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW35_07515	COG0730	response to heat
EXW35_07520	COG0306	phosphate transporter
EXW35_07525	COG1392	Phosphate transport regulator
EXW35_07530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW35_07545	COG3852	Histidine kinase
EXW35_07550	COG1801	Protein of unknown function DUF72
EXW35_07560	COG0582	viral genome integration into host DNA
EXW35_07565	COG5002	protein histidine kinase activity
EXW35_07580	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW35_07580	COG0392	lysyltransferase activity
EXW35_07595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW35_07600	COG1686	Belongs to the peptidase S11 family
EXW35_07605	COG2715	membrane protein required for spore maturation
EXW35_07610	COG0700	Nucleoside recognition
EXW35_07615	COG1187	pseudouridine synthase activity
EXW35_07625	COG1333	cytochrome c biogenesis protein
EXW35_07630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW35_07635	COG0745	RESPONSE REGULATOR receiver
EXW35_07640	COG5002	protein histidine kinase activity
EXW35_07645	COG2096	Adenosyltransferase
EXW35_07650	COG4942	peptidase
EXW35_07660	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW35_07665	COG1141	Ferredoxin
EXW35_07675	COG4955	Helix-turn-helix domain
EXW35_07680	COG0514	ATP-dependent DNA helicase (RecQ)
EXW35_07685	COG1266	CAAX protease self-immunity
EXW35_07695	COG1408	metallophosphoesterase
EXW35_07710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW35_07730	COG0492	ferredoxin-NADP+ reductase activity
EXW35_07735	COG0252	asparaginase activity
EXW35_07740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW35_07750	COG1304	FMN binding
EXW35_07785	COG1160	GTP binding
EXW35_07790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW35_07810	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW35_07820	COG0302	gtp cyclohydrolase
EXW35_07825	COG0142	geranyltranstransferase activity
EXW35_07830	COG2226	methyltransferase
EXW35_07835	COG0142	geranyltranstransferase activity
EXW35_07850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW35_07860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW35_07865	COG0457	Tetratricopeptide repeat
EXW35_07870	COG5582	Belongs to the UPF0302 family
EXW35_07885	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW35_07905	COG4347	Protein of unknown function (DUF1405)
EXW35_07920	COG2738	Putative neutral zinc metallopeptidase
EXW35_07930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW35_07940	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW35_07945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW35_07950	COG1803	Methylglyoxal synthase
EXW35_07955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW35_07960	COG0438	transferase activity, transferring glycosyl groups
EXW35_07965	COG0617	tRNA 3'-terminal CCA addition
EXW35_07975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW35_07980	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW35_07990	COG1199	ATP-dependent helicase activity
EXW35_07990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW35_08010	COG3935	DnaD domain protein
EXW35_08015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW35_08025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW35_08025	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW35_08030	COG3331	DNA recombination
EXW35_08065	COG4474	Belongs to the UPF0398 family
EXW35_08070	COG3599	regulation of cell shape
EXW35_08080	COG0116	Belongs to the methyltransferase superfamily
EXW35_08090	COG1199	ATP-dependent helicase activity
EXW35_08095	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW35_08105	COG0024	Methionine aminopeptidase
EXW35_08115	COG2233	PERMEase
EXW35_08120	COG2311	Membrane
EXW35_08125	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW35_08135	COG0456	acetyltransferase
EXW35_08145	COG2897	thiosulfate sulfurtransferase activity
EXW35_08185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW35_08210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW35_08225	COG1215	transferase activity, transferring glycosyl groups
EXW35_08230	COG0438	transferase activity, transferring glycosyl groups
EXW35_08245	COG0454	-acetyltransferase
EXW35_08265	COG0328	RNA-DNA hybrid ribonuclease activity
EXW35_08300	COG3403	YqcI/YcgG family
EXW35_08305	COG1280	lysine exporter protein (LysE YggA)
EXW35_08320	COG3162	membrane
EXW35_08325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW35_08330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW35_08340	COG0475	glutathione-regulated potassium exporter activity
EXW35_08345	COG4978	Transcriptional regulator
EXW35_08345	COG0789	Transcriptional regulator
EXW35_08355	COG2323	membrane
EXW35_08360	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW35_08390	COG2814	Major facilitator Superfamily
EXW35_08410	COG1923	regulation of RNA biosynthetic process
EXW35_08435	COG0835	chemotaxis
EXW35_08435	COG0784	Response regulator, receiver
EXW35_08455	COG0697	spore germination
EXW35_08470	COG0861	Integral membrane protein TerC family
EXW35_08480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW35_08495	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW35_08500	COG1776	CheC inhibitor of MCP methylation
EXW35_08500	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW35_08510	COG1338	Plays a role in the flagellum-specific transport system
EXW35_08515	COG1987	bacterial-type flagellum assembly
EXW35_08525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW35_08530	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW35_08535	COG1419	protein localization to endoplasmic reticulum
EXW35_08540	COG4786	Flagellar basal body rod
EXW35_08545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW35_08580	COG2329	Antibiotic biosynthesis monooxygenase
EXW35_08595	COG2814	Major facilitator Superfamily
EXW35_08605	COG0583	DNA-binding transcription factor activity
EXW35_08610	COG3842	ATPase activity
EXW35_08660	COG0406	alpha-ribazole phosphatase activity
EXW35_08690	COG0367	asparagine synthase
EXW35_08720	COG1802	Transcriptional regulator
EXW35_08725	COG0697	spore germination
EXW35_08740	COG1216	Glycosyl transferase, family 2
EXW35_08740	COG0438	transferase activity, transferring glycosyl groups
EXW35_08745	COG1757	Na H antiporter
EXW35_08755	COG0277	FAD linked oxidase domain protein
EXW35_08775	COG0534	Mate efflux family protein
EXW35_08780	COG3340	Belongs to the peptidase S51 family
EXW35_08800	COG0785	Cytochrome C biogenesis protein
EXW35_08805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW35_08820	COG3048	D-serine ammonia-lyase activity
EXW35_08825	COG2733	membrane
EXW35_08865	COG1131	(ABC) transporter
EXW35_08880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW35_08885	COG0528	UMP kinase activity
EXW35_08895	COG1027	Aspartate ammonia-lyase
EXW35_08900	COG0281	malic enzyme
EXW35_08905	COG4191	Histidine kinase
EXW35_08910	COG0784	Response regulator, receiver
EXW35_08915	COG1846	Transcriptional regulator
EXW35_08925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW35_08940	COG2502	aspartate--ammonia ligase
EXW35_08995	COG1051	belongs to the nudix hydrolase family
EXW35_09000	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW35_09010	COG2814	Major facilitator Superfamily
EXW35_09040	COG0477	Major facilitator Superfamily
EXW35_09045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW35_09055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW35_09065	COG2223	nitrite transmembrane transporter activity
EXW35_09070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW35_09085	COG2244	polysaccharide biosynthetic process
EXW35_09090	COG0733	neurotransmitter:sodium symporter activity
EXW35_09100	COG5566	PFAM Mor transcription activator
EXW35_09105	COG2323	membrane
EXW35_09120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW35_09130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW35_09135	COG0028	Belongs to the TPP enzyme family
EXW35_09150	COG0129	dihydroxy-acid dehydratase activity
EXW35_09155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW35_09180	COG2814	Major facilitator Superfamily
EXW35_09185	COG3384	dioxygenase
EXW35_09210	COG4166	transmembrane transport
EXW35_09215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW35_09225	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW35_09230	COG1054	Belongs to the UPF0176 family
EXW35_09240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW35_09245	COG0531	amino acid
EXW35_09280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW35_09295	COG4257	antibiotic catabolic process
EXW35_09300	COG2390	Transcriptional regulator
EXW35_09310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW35_09315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW35_09320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW35_09335	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW35_09350	COG0583	DNA-binding transcription factor activity
EXW35_09370	COG0006	proline dipeptidase activity
EXW35_09375	COG2132	Multicopper oxidase
EXW35_09390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW35_09410	COG1114	Component of the transport system for branched-chain amino acids
EXW35_09420	COG4641	Protein conserved in bacteria
EXW35_09435	COG1276	copper resistance
EXW35_09435	COG2372	response to copper ion
EXW35_09440	COG4549	nuclear export factor GLE1
EXW35_09450	COG0697	spore germination
EXW35_09455	COG0583	DNA-binding transcription factor activity
EXW35_09460	COG1959	2 iron, 2 sulfur cluster binding
EXW35_09465	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW35_09470	COG0778	Nitroreductase
EXW35_09495	COG0628	permease
EXW35_09510	COG1231	oxidoreductase activity
EXW35_09515	COG0523	cobalamin synthesis protein
EXW35_09525	COG0318	PFAM AMP-dependent synthetase and ligase
EXW35_09530	COG2030	dehydratase
EXW35_09535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW35_09550	COG0411	ABC transporter
EXW35_09570	COG0583	DNA-binding transcription factor activity
EXW35_09580	COG1942	4-Oxalocrotonate Tautomerase
EXW35_09595	COG0346	lactoylglutathione lyase activity
EXW35_09605	COG1271	oxidase subunit
EXW35_09610	COG1294	oxidase, subunit
EXW35_09615	COG4988	ABC transporter
EXW35_09620	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW35_09650	COG1686	Belongs to the peptidase S11 family
EXW35_09665	COG0791	NLP P60 protein
EXW35_09665	COG1388	LysM domain
EXW35_09675	COG1132	(ABC) transporter
EXW35_09680	COG0745	RESPONSE REGULATOR receiver
EXW35_09685	COG5002	protein histidine kinase activity
EXW35_09690	COG0300	oxidoreductase activity
EXW35_09695	COG4122	O-methyltransferase activity
EXW35_09725	COG0460	homoserine dehydrogenase
EXW35_09735	COG0083	homoserine kinase activity
EXW35_09750	COG1316	TRANSCRIPTIONal
EXW35_09775	COG1285	pathogenesis
EXW35_09780	COG1247	-acetyltransferase
EXW35_09800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW35_09810	COG1082	Xylose isomerase domain protein TIM barrel
EXW35_09820	COG2814	Major facilitator Superfamily
EXW35_09825	COG1279	arginine transmembrane transporter activity
EXW35_09830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW35_09840	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW35_09870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW35_09875	COG0577	efflux transmembrane transporter activity
EXW35_09880	COG2002	toxin-antitoxin pair type II binding
EXW35_09885	COG1404	Belongs to the peptidase S8 family
EXW35_09890	COG0640	Transcriptional regulator
EXW35_09895	COG0667	Aldo Keto reductase
EXW35_09940	COG3949	Membrane
EXW35_09945	COG0783	Belongs to the Dps family
EXW35_09960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW35_09970	COG1231	oxidoreductase activity
EXW35_09975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW35_09980	COG4989	oxidoreductase activity
EXW35_09985	COG0523	cobalamin synthesis protein
EXW35_09990	COG0456	acetyltransferase
EXW35_09995	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW35_10020	COG1136	(ABC) transporter
EXW35_10025	COG0577	efflux transmembrane transporter activity
EXW35_10030	COG0745	RESPONSE REGULATOR receiver
EXW35_10035	COG2205	protein histidine kinase activity
EXW35_10040	COG1902	pentaerythritol trinitrate reductase activity
EXW35_10045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW35_10055	COG4166	transmembrane transport
EXW35_10060	COG0346	lactoylglutathione lyase activity
EXW35_10070	COG0406	alpha-ribazole phosphatase activity
EXW35_10080	COG5337	Spore coat protein CotH
EXW35_10085	COG1051	belongs to the nudix hydrolase family
EXW35_10090	COG0586	Pfam SNARE associated Golgi protein
EXW35_10095	COG2244	polysaccharide biosynthetic process
EXW35_10105	COG0701	Predicted permease
EXW35_10110	COG3689	TIGRFAM TIGR03943 family protein
EXW35_10115	COG1607	acyl-coa hydrolase
EXW35_10125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW35_10145	COG0702	epimerase
EXW35_10150	COG2839	Protein conserved in bacteria
EXW35_10155	COG1253	flavin adenine dinucleotide binding
EXW35_10180	COG1114	Component of the transport system for branched-chain amino acids
EXW35_10185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW35_10205	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW35_10220	COG1876	peptidase activity
EXW35_10225	COG0494	nUDIX hydrolase
EXW35_10235	COG2211	Major facilitator Superfamily
EXW35_10250	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW35_10260	COG0561	phosphatase activity
EXW35_10265	COG1846	Transcriptional regulator
EXW35_10270	COG2814	Major facilitator Superfamily
EXW35_10280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW35_10300	COG1819	glycosyl
EXW35_10305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW35_10310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW35_10335	COG0456	acetyltransferase
EXW35_10355	COG3874	Sporulation protein YtfJ
EXW35_10380	COG2226	methyltransferase
EXW35_10410	COG0604	alcohol dehydrogenase
EXW35_10415	COG1595	DNA-templated transcription, initiation
EXW35_10440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW35_10440	COG0426	domain, Protein
EXW35_10450	COG0386	Belongs to the glutathione peroxidase family
EXW35_10455	COG1305	Transglutaminase-like
EXW35_10460	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW35_10465	COG0714	Associated with various cellular activities
EXW35_10480	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW35_10485	COG1140	nitrate reductase beta subunit
EXW35_10490	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW35_10495	COG2181	nitrate reductase activity
EXW35_10500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW35_10505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW35_10510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW35_10515	COG0303	'Molybdopterin
EXW35_10520	COG0314	molybdopterin synthase activity
EXW35_10530	COG2223	nitrite transmembrane transporter activity
EXW35_10555	COG1648	precorrin-2 dehydrogenase activity
EXW35_10565	COG1587	Uroporphyrinogen-III synthase
EXW35_10565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW35_10570	COG2146	nitrite reductase [NAD(P)H] activity
EXW35_10575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW35_10600	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW35_10630	COG2359	stage V sporulation protein S
EXW35_10640	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW35_10650	COG5444	nuclease activity
EXW35_10660	COG1418	mRNA catabolic process
EXW35_10665	COG0488	(ABC) transporter
EXW35_10705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW35_10775	COG1413	lyase activity
EXW35_10790	COG2136	Putative SAM-dependent methyltransferase
EXW35_10790	COG2521	methyltransferase
EXW35_10795	COG0018	arginyl-trna synthetase
EXW35_10855	COG0017	Asparaginyl-tRNA synthetase
EXW35_10860	COG0733	neurotransmitter:sodium symporter activity
EXW35_10885	COG2610	gluconate transmembrane transporter activity
EXW35_10895	COG1794	racemase activity, acting on amino acids and derivatives
EXW35_10905	COG0456	acetyltransferase
EXW35_10910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW35_10920	COG1131	(ABC) transporter
EXW35_10925	COG4473	ABC transporter
EXW35_10935	COG0546	phosphoglycolate phosphatase activity
EXW35_10950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW35_10965	COG0768	penicillin binding
EXW35_10975	COG0204	Acyl-transferase
EXW35_10980	COG1272	protein, Hemolysin III
EXW35_10985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW35_10990	COG0805	protein transport
EXW35_11010	COG1999	signal sequence binding
EXW35_11015	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW35_11020	COG0367	asparagine synthase
EXW35_11035	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW35_11040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW35_11045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW35_11065	COG1335	isochorismatase
EXW35_11075	COG0668	transmembrane transport
EXW35_11080	COG4585	Histidine kinase
EXW35_11080	COG2203	Gaf domain
EXW35_11085	COG2197	response regulator
EXW35_11090	COG1737	Transcriptional regulator
EXW35_11095	COG1064	alcohol dehydrogenase
EXW35_11110	COG1070	Carbohydrate kinase
EXW35_11120	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW35_11140	COG0517	IMP dehydrogenase activity
EXW35_11140	COG1125	glycine betaine transport
EXW35_11145	COG1174	glycine betaine transport
EXW35_11180	COG1253	flavin adenine dinucleotide binding
EXW35_11185	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_11190	COG5506	Protein of unknown function (DUF1694)
EXW35_11205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW35_11210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW35_11215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW35_11220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW35_11225	COG0456	acetyltransferase
EXW35_11230	COG3829	transcription factor binding
EXW35_11235	COG1509	lysine 2,3-aminomutase activity
EXW35_11245	COG4479	Belongs to the UPF0346 family
EXW35_11270	COG4991	sh3 domain protein
EXW35_11270	COG0515	serine threonine protein kinase
EXW35_11270	COG3064	Membrane
EXW35_11280	COG0671	phosphoesterase, PA-phosphatase related
EXW35_11285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW35_11290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW35_11355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW35_11380	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_11400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW35_11400	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW35_11410	COG2814	Major facilitator Superfamily
EXW35_11420	COG0372	Belongs to the citrate synthase family
EXW35_11425	COG2079	MmgE PrpD family protein
EXW35_11430	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW35_11435	COG1960	acyl-CoA dehydrogenase activity
EXW35_11440	COG2084	Dehydrogenase
EXW35_11445	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_11450	COG1280	lysine exporter protein (LysE YggA)
EXW35_11455	COG1024	Enoyl-CoA hydratase
EXW35_11470	COG0420	3'-5' exonuclease activity
EXW35_11490	COG2223	nitrite transmembrane transporter activity
EXW35_11495	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_11500	COG1169	isochorismate synthase
EXW35_11505	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW35_11510	COG1535	isochorismatase
EXW35_11510	COG3433	isochorismatase activity
EXW35_11515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW35_11525	COG2814	Major facilitator Superfamily
EXW35_11540	COG0776	regulation of translation
EXW35_11550	COG2318	DinB family
EXW35_11555	COG1115	amino acid carrier protein
EXW35_11570	COG2329	Antibiotic biosynthesis monooxygenase
EXW35_11585	COG1187	pseudouridine synthase activity
EXW35_11590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW35_11595	COG3655	Transcriptional regulator
EXW35_11605	COG1136	(ABC) transporter
EXW35_11615	COG0596	Alpha beta hydrolase
EXW35_11630	COG0028	Belongs to the TPP enzyme family
EXW35_11640	COG2226	methyltransferase
EXW35_11655	COG1253	flavin adenine dinucleotide binding
EXW35_11685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW35_11705	COG1846	Transcriptional regulator
EXW35_11715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW35_11720	COG1309	transcriptional regulator
EXW35_11750	COG1247	-acetyltransferase
EXW35_11790	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW35_11800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW35_11900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW35_11900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW35_11995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW35_12140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW35_12215	COG0561	phosphatase activity
EXW35_12225	COG0583	DNA-binding transcription factor activity
EXW35_12230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW35_12245	COG0583	DNA-binding transcription factor activity
EXW35_12250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW35_12255	COG2258	MOSC domain
EXW35_12270	COG1132	(ABC) transporter
EXW35_12275	COG1132	(ABC) transporter
EXW35_12290	COG0189	ligase activity
EXW35_12315	COG1396	sequence-specific DNA binding
EXW35_12350	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW35_12355	COG1595	DNA-templated transcription, initiation
EXW35_12375	COG1649	PFAM Uncharacterised BCR, COG1649
EXW35_12395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW35_12400	COG2971	BadF BadG BcrA BcrD
EXW35_12410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW35_12460	COG1309	transcriptional regulator
EXW35_12475	COG1136	(ABC) transporter
EXW35_12480	COG3615	Tellurite resistance protein tehB
EXW35_12480	COG0500	methyltransferase
EXW35_12490	COG0693	protein deglycase activity
EXW35_12500	COG0588	phosphoglycerate mutase activity
EXW35_12520	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW35_12525	COG0110	maltose O-acetyltransferase activity
EXW35_12540	COG1136	(ABC) transporter
EXW35_12575	COG1686	Belongs to the peptidase S11 family
EXW35_12600	COG0768	penicillin binding
EXW35_12605	COG0745	RESPONSE REGULATOR receiver
EXW35_12610	COG2205	protein histidine kinase activity
EXW35_12615	COG1136	(ABC) transporter
EXW35_12620	COG0577	efflux transmembrane transporter activity
EXW35_12630	COG1595	DNA-templated transcription, initiation
EXW35_12640	COG0768	penicillin binding
EXW35_12645	COG0768	penicillin binding
EXW35_12680	COG1252	NADH dehydrogenase
EXW35_12685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW35_12685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW35_12710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW35_12710	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW35_12735	COG1136	(ABC) transporter
EXW35_12740	COG0577	efflux transmembrane transporter activity
EXW35_12760	COG1136	(ABC) transporter
EXW35_12780	COG2723	6-phospho-beta-galactosidase activity
EXW35_12865	COG1114	Component of the transport system for branched-chain amino acids
EXW35_12875	COG2239	Acts as a magnesium transporter
EXW35_12910	COG0697	spore germination
EXW35_12935	COG3397	chitin binding
EXW35_12940	COG0823	Involved in the tonB-independent uptake of proteins
EXW35_12950	COG1408	metallophosphoesterase
EXW35_12960	COG1131	(ABC) transporter
EXW35_12970	COG1309	transcriptional regulator
EXW35_12980	COG1960	acyl-CoA dehydrogenase activity
EXW35_12985	COG0439	Biotin carboxylase
EXW35_12990	COG0511	ligase activity, forming carbon-carbon bonds
EXW35_12995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW35_13000	COG1024	Enoyl-CoA hydratase
EXW35_13005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW35_13010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW35_13050	COG0572	uridine kinase
EXW35_13055	COG2318	DinB family
EXW35_13085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW35_13115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW35_13140	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_13145	COG1733	regulation of RNA biosynthetic process
EXW35_13170	COG1309	transcriptional regulator
EXW35_13200	COG0697	spore germination
EXW35_13205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW35_13235	COG2323	membrane
EXW35_13250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW35_13255	COG0697	spore germination
EXW35_13275	COG0201	protein transport
EXW35_13285	COG0737	Belongs to the 5'-nucleotidase family
EXW35_13295	COG3227	Zinc metalloprotease (Elastase)
EXW35_13300	COG1523	belongs to the glycosyl hydrolase 13 family
EXW35_13315	COG0076	glutamate decarboxylase activity
EXW35_13320	COG0657	acetylesterase activity
EXW35_13330	COG1073	alpha beta
EXW35_13340	COG0577	efflux transmembrane transporter activity
EXW35_13345	COG1136	(ABC) transporter
EXW35_13375	COG5002	protein histidine kinase activity
EXW35_13380	COG0745	RESPONSE REGULATOR receiver
EXW35_13385	COG1011	Hydrolase
EXW35_13405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW35_13410	COG1183	phosphatidylcholine synthase activity
EXW35_13420	COG1132	(ABC) transporter
EXW35_13430	COG3961	Belongs to the TPP enzyme family
EXW35_13450	COG0322	excinuclease ABC activity
EXW35_13475	COG2318	DinB family
EXW35_13490	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW35_13515	COG3878	Protein conserved in bacteria
EXW35_13540	COG1051	belongs to the nudix hydrolase family
EXW35_13545	COG0592	DNA-directed DNA polymerase activity
EXW35_13550	COG2816	NAD+ diphosphatase activity
EXW35_13560	COG2223	nitrite transmembrane transporter activity
EXW35_13565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW35_13575	COG0494	nUDIX hydrolase
EXW35_13595	COG0697	spore germination
EXW35_13600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW35_13610	COG0584	glycerophosphoryl diester phosphodiesterase
EXW35_13625	COG2814	Major facilitator Superfamily
EXW35_13665	COG0768	penicillin binding
EXW35_13670	COG0671	phosphoesterase, PA-phosphatase related
EXW35_13675	COG0604	alcohol dehydrogenase
EXW35_13680	COG5002	protein histidine kinase activity
EXW35_13685	COG0745	RESPONSE REGULATOR receiver
EXW35_13695	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW35_13705	COG2205	protein histidine kinase activity
EXW35_13720	COG1122	ATPase activity
EXW35_13725	COG4720	Psort location CytoplasmicMembrane, score
EXW35_13730	COG1794	racemase activity, acting on amino acids and derivatives
EXW35_13735	COG1819	glycosyl
EXW35_13745	COG0768	penicillin binding
EXW35_13750	COG5002	protein histidine kinase activity
EXW35_13755	COG0561	phosphatase activity
EXW35_13805	COG2124	cytochrome p450
EXW35_13850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW35_13860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW35_13865	COG0460	homoserine dehydrogenase
EXW35_13885	COG0577	efflux transmembrane transporter activity
EXW35_13890	COG1136	(ABC) transporter
EXW35_13900	COG0488	(ABC) transporter
EXW35_13905	COG0667	Aldo Keto reductase
EXW35_13910	COG0583	DNA-binding transcription factor activity
EXW35_13915	COG2205	protein histidine kinase activity
EXW35_13920	COG0745	RESPONSE REGULATOR receiver
EXW35_13930	COG3773	Cell wall hydrolase
EXW35_13935	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW35_13945	COG3386	PFAM SMP-30 Gluconolaconase
EXW35_13985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW35_14000	COG2959	enzyme of heme biosynthesis
EXW35_14030	COG3483	tryptophan 2,3-dioxygenase activity
EXW35_14035	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW35_14040	COG3844	kynureninase activity
EXW35_14045	COG1309	transcriptional regulator
EXW35_14060	COG3284	Transcriptional regulator
EXW35_14075	COG1349	DNA-binding transcription factor activity
EXW35_14105	COG1959	2 iron, 2 sulfur cluster binding
EXW35_14120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW35_14125	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW35_14130	COG0022	dehydrogenase e1 component
EXW35_14135	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW35_14155	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_14160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW35_14160	COG0456	acetyltransferase
EXW35_14190	COG4176	ABC-type proline glycine betaine transport system permease component
EXW35_14195	COG4175	Glycine betaine
EXW35_14195	COG0517	IMP dehydrogenase activity
EXW35_14220	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW35_14225	COG2153	protein acetylation
EXW35_14230	COG3397	chitin binding
EXW35_14240	COG1819	glycosyl
EXW35_14255	COG2205	protein histidine kinase activity
EXW35_14260	COG2315	Protein conserved in bacteria
EXW35_14310	COG3973	AAA domain
EXW35_14320	COG2105	PFAM AIG2 family protein
EXW35_14325	COG0514	ATP-dependent DNA helicase (RecQ)
EXW35_14345	COG4637	Psort location Cytoplasmic, score
EXW35_14355	COG1227	inorganic diphosphatase activity
EXW35_14360	COG3397	chitin binding
EXW35_14365	COG2318	DinB family
EXW35_14385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW35_14390	COG1115	amino acid carrier protein
EXW35_14395	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_14400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW35_14410	COG3938	Belongs to the proline racemase family
EXW35_14415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW35_14455	COG0586	Pfam SNARE associated Golgi protein
EXW35_14470	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW35_14475	COG4166	transmembrane transport
EXW35_14485	COG4948	Mandelate Racemase Muconate Lactonizing
EXW35_14505	COG0667	Aldo Keto reductase
EXW35_14545	COG2936	dipeptidyl-peptidase activity
EXW35_14555	COG0745	RESPONSE REGULATOR receiver
EXW35_14585	COG1164	Oligoendopeptidase f
EXW35_14590	COG0531	amino acid
EXW35_14595	COG1522	sequence-specific DNA binding
EXW35_14610	COG1307	EDD domain protein, DegV family
EXW35_14640	COG1335	isochorismatase
EXW35_14655	COG2814	Major facilitator Superfamily
EXW35_14665	COG1664	Polymer-forming cytoskeletal
EXW35_14670	COG0789	Transcriptional regulator
EXW35_14675	COG4533	DNA binding
EXW35_14680	COG0477	Major facilitator Superfamily
EXW35_14680	COG2814	Major facilitator Superfamily
EXW35_14700	COG2261	transglycosylase associated protein
EXW35_14715	COG2226	methyltransferase
EXW35_14750	COG0436	Aminotransferase
EXW35_14755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW35_14785	COG1131	(ABC) transporter
EXW35_14790	COG2188	Transcriptional regulator
EXW35_14830	COG0628	permease
EXW35_14875	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW35_14885	COG0697	spore germination
EXW35_14890	COG2318	DinB family
EXW35_14940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW35_14950	COG2814	Major facilitator Superfamily
EXW35_14955	COG1368	sulfuric ester hydrolase activity
EXW35_14970	COG0488	(ABC) transporter
EXW35_14975	COG1033	growth of symbiont in host cell
EXW35_14975	COG2409	Drug exporters of the RND superfamily
EXW35_14985	COG1309	transcriptional regulator
EXW35_14990	COG0494	nUDIX hydrolase
EXW35_15010	COG0287	Prephenate dehydrogenase
EXW35_15025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW35_15025	COG1605	Chorismate mutase
EXW35_15065	COG1388	LysM domain
EXW35_15065	COG3584	3D domain protein
EXW35_15075	COG0346	lactoylglutathione lyase activity
EXW35_15085	COG0431	NADPH-dependent FMN reductase
EXW35_15115	COG0579	oxidoreductase
EXW35_15120	COG1879	ABC-type sugar transport system periplasmic component
EXW35_15135	COG1129	ABC transporter
EXW35_15140	COG2390	Transcriptional regulator
EXW35_15160	COG2226	methyltransferase
EXW35_15180	COG2329	Antibiotic biosynthesis monooxygenase
EXW35_15205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW35_15210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW35_15215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW35_15220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW35_15225	COG3239	Fatty acid desaturase
EXW35_15245	COG3842	ATPase activity
EXW35_15270	COG1175	transmembrane transport
EXW35_15275	COG1349	DNA-binding transcription factor activity
EXW35_15285	COG3655	Transcriptional regulator
EXW35_15310	COG3279	Response regulator of the LytR AlgR family
EXW35_15325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW35_15330	COG0346	lactoylglutathione lyase activity
EXW35_15365	COG0714	Associated with various cellular activities
EXW35_15385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW35_15390	COG0753	catalase activity
EXW35_15400	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW35_15425	COG0714	Associated with various cellular activities
EXW35_15435	COG0778	Nitroreductase
EXW35_15440	COG1846	Transcriptional regulator
EXW35_15460	COG0494	nUDIX hydrolase
EXW35_15480	COG1725	Transcriptional regulator
EXW35_15510	COG2207	Transcriptional regulator
EXW35_15515	COG0456	acetyltransferase
EXW35_15530	COG0697	spore germination
EXW35_15535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW35_15540	COG1671	Belongs to the UPF0178 family
EXW35_15565	COG0814	amino acid
EXW35_15570	COG0697	spore germination
EXW35_15585	COG0745	RESPONSE REGULATOR receiver
EXW35_15590	COG0596	Alpha beta hydrolase
EXW35_15600	COG0456	acetyltransferase
EXW35_15600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW35_15625	COG0730	response to heat
EXW35_15635	COG0833	amino acid
EXW35_15645	COG4335	DNA alkylation repair
EXW35_15675	COG0681	Belongs to the peptidase S26 family
EXW35_15680	COG0768	penicillin binding
EXW35_15695	COG3104	oligopeptide transport
EXW35_15700	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW35_15715	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW35_15720	COG1984	allophanate hydrolase subunit 2
EXW35_15725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW35_15730	COG1414	Transcriptional regulator
EXW35_15750	COG1960	acyl-CoA dehydrogenase activity
EXW35_15775	COG0640	Transcriptional regulator
EXW35_15785	COG3314	Sporulation integral membrane protein YlbJ
EXW35_15805	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW35_15810	COG0577	efflux transmembrane transporter activity
EXW35_15815	COG0577	efflux transmembrane transporter activity
EXW35_15820	COG1136	(ABC) transporter
EXW35_15850	COG0574	Belongs to the PEP-utilizing enzyme family
EXW35_15850	COG3848	Pyruvate phosphate dikinase
EXW35_15860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW35_15885	COG5002	protein histidine kinase activity
EXW35_15890	COG0745	RESPONSE REGULATOR receiver
EXW35_15900	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW35_15920	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW35_15925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW35_15930	COG1121	(ABC) transporter
EXW35_15950	COG0798	PFAM Bile acid sodium symporter
EXW35_15955	COG0346	lactoylglutathione lyase activity
EXW35_15960	COG0640	Transcriptional regulator
EXW35_15975	COG1309	transcriptional regulator
EXW35_15980	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_15985	COG1522	sequence-specific DNA binding
EXW35_16000	COG0346	lactoylglutathione lyase activity
EXW35_16030	COG0745	RESPONSE REGULATOR receiver
EXW35_16035	COG3850	Histidine kinase
EXW35_16035	COG5002	protein histidine kinase activity
EXW35_16070	COG1073	alpha beta
EXW35_16080	COG0814	amino acid
EXW35_16085	COG1760	l-serine dehydratase
EXW35_16090	COG1760	l-serine dehydratase
EXW35_16100	COG5002	protein histidine kinase activity
EXW35_16105	COG0745	RESPONSE REGULATOR receiver
EXW35_16115	COG5002	protein histidine kinase activity
EXW35_16140	COG4977	sequence-specific DNA binding
EXW35_16180	COG2814	Major facilitator Superfamily
EXW35_16195	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW35_16220	COG1522	sequence-specific DNA binding
EXW35_16230	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW35_16245	COG1136	(ABC) transporter
EXW35_16250	COG0577	efflux transmembrane transporter activity
EXW35_16270	COG3850	Histidine kinase
EXW35_16270	COG5002	protein histidine kinase activity
EXW35_16280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW35_16315	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW35_16335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW35_16375	COG2814	Major facilitator Superfamily
EXW35_16455	COG2849	repeat protein
EXW35_16570	COG0477	Major facilitator Superfamily
EXW35_16585	COG1846	Transcriptional regulator
EXW35_16590	COG2814	Major facilitator Superfamily
EXW35_16610	COG0640	Transcriptional regulator
EXW35_16640	COG1329	Transcriptional regulator
EXW35_16695	COG5002	protein histidine kinase activity
EXW35_16710	COG1136	(ABC) transporter
EXW35_16725	COG1131	(ABC) transporter
EXW35_16825	COG4187	Peptidase family M20/M25/M40
EXW35_16840	COG2031	fatty acid transporter
EXW35_16850	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW35_16900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW35_16905	COG1288	antiporter activity
EXW35_16910	COG2356	endonuclease I
EXW35_16915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW35_16935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW35_16955	COG1785	Belongs to the alkaline phosphatase family
EXW35_16960	COG0778	Nitroreductase
EXW35_16965	COG1733	regulation of RNA biosynthetic process
EXW35_16985	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_16995	COG1131	(ABC) transporter
EXW35_17025	COG1595	DNA-templated transcription, initiation
EXW35_17040	COG1011	Hydrolase
EXW35_17045	COG2365	Tyrosine phosphatase family
EXW35_17070	COG0346	lactoylglutathione lyase activity
EXW35_17075	COG1940	carbohydrate kinase activity
EXW35_17080	COG0738	Major facilitator superfamily
EXW35_17085	COG0110	maltose O-acetyltransferase activity
EXW35_17100	COG0628	permease
EXW35_17105	COG2261	transglycosylase associated protein
EXW35_17115	COG1720	tRNA m6t6A37 methyltransferase activity
EXW35_17135	COG0477	Major facilitator Superfamily
EXW35_17150	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW35_17160	COG1253	flavin adenine dinucleotide binding
EXW35_17165	COG0789	Transcriptional regulator
EXW35_17175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW35_17200	COG0697	spore germination
EXW35_17210	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW35_17215	COG3813	Protein conserved in bacteria
EXW35_17220	COG2706	6-phosphogluconolactonase activity
EXW35_17225	COG1070	Carbohydrate kinase
EXW35_17235	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW35_17240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW35_17255	COG0814	amino acid
EXW35_17275	COG1393	Belongs to the ArsC family
EXW35_17285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW35_17300	COG0494	nUDIX hydrolase
EXW35_17315	COG0384	phenazine biosynthesis protein PhzF
EXW35_17325	COG0318	PFAM AMP-dependent synthetase and ligase
EXW35_17330	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW35_17335	COG1733	regulation of RNA biosynthetic process
EXW35_17360	COG1191	sigma factor activity
EXW35_17375	COG1876	peptidase activity
EXW35_17415	COG0741	lytic transglycosylase activity
EXW35_17440	COG4585	Histidine kinase
EXW35_17445	COG2197	response regulator
EXW35_17470	COG5002	protein histidine kinase activity
EXW35_17520	COG0814	amino acid
EXW35_17545	COG1151	hydroxylamine reductase activity
EXW35_17570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW35_17580	COG2072	flavoprotein involved in K transport
EXW35_17625	COG1695	Transcriptional regulator
EXW35_17630	COG0604	alcohol dehydrogenase
EXW35_17635	COG1113	amino acid transport
EXW35_17645	COG2814	Major facilitator Superfamily
EXW35_17655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW35_17660	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_17670	COG0534	Mate efflux family protein
EXW35_17675	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_17680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW35_17695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW35_17700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW35_17720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW35_17725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW35_17730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW35_17735	COG3739	integral membrane protein
EXW35_17755	COG0583	DNA-binding transcription factor activity
EXW35_17780	COG1193	negative regulation of DNA recombination
EXW35_17790	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW35_17795	COG1164	Oligoendopeptidase f
EXW35_17800	COG2957	Belongs to the agmatine deiminase family
EXW35_17820	COG3781	membrane
EXW35_17835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW35_17870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW35_17875	COG0640	Transcriptional regulator
EXW35_17880	COG0604	alcohol dehydrogenase
EXW35_17885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW35_17895	COG0457	Tetratricopeptide repeat
EXW35_17900	COG2808	Putative FMN-binding domain
EXW35_17915	COG0277	FAD linked oxidase domain protein
EXW35_17935	COG1285	pathogenesis
EXW35_17945	COG2514	catechol 2,3-dioxygenase activity
EXW35_17950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW35_17955	COG1126	abc transporter atp-binding protein
EXW35_17960	COG0765	amino acid transport
EXW35_17965	COG2720	vancomycin resistance protein
EXW35_17990	COG1278	Cold shock
EXW35_18000	COG0716	FMN binding
EXW35_18010	COG0494	nUDIX hydrolase
EXW35_18030	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_18040	COG0165	Argininosuccinate lyase
EXW35_18055	COG4145	pantothenate transmembrane transporter activity
EXW35_18065	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_18070	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_18080	COG1657	PFAM Prenyltransferase squalene oxidase
EXW35_18085	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW35_18090	COG2962	Rard protein
EXW35_18095	COG3326	Membrane
EXW35_18100	COG0531	amino acid
EXW35_18135	COG2226	methyltransferase
EXW35_18140	COG4166	transmembrane transport
EXW35_18145	COG4166	transmembrane transport
EXW35_18150	COG4166	transmembrane transport
EXW35_18155	COG1316	TRANSCRIPTIONal
EXW35_18165	COG1595	DNA-templated transcription, initiation
EXW35_18175	COG1131	(ABC) transporter
EXW35_18195	COG0673	inositol 2-dehydrogenase activity
EXW35_18205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW35_18210	COG0187	DNA topoisomerase II activity
EXW35_18215	COG1832	CoA-binding protein
EXW35_18220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW35_18225	COG0745	RESPONSE REGULATOR receiver
EXW35_18235	COG1328	CTP reductase activity
EXW35_18245	COG4841	protein insertion into membrane
EXW35_18250	COG0824	Thioesterase
EXW35_18275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW35_18295	COG1132	(ABC) transporter
EXW35_18300	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW35_18330	COG2211	Major facilitator Superfamily
EXW35_18340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW35_18355	COG0183	Belongs to the thiolase family
EXW35_18360	COG0318	PFAM AMP-dependent synthetase and ligase
EXW35_18365	COG1268	BioY protein
EXW35_18370	COG0318	PFAM AMP-dependent synthetase and ligase
EXW35_18375	COG1396	sequence-specific DNA binding
EXW35_18395	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EXW35_18415	COG0830	nickel cation binding
EXW35_18455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW35_18470	COG5002	protein histidine kinase activity
EXW35_18480	COG0400	carboxylic ester hydrolase activity
EXW35_18485	COG0346	lactoylglutathione lyase activity
EXW35_18490	COG0069	glutamate synthase activity
EXW35_18495	COG1902	pentaerythritol trinitrate reductase activity
EXW35_18505	COG1329	Transcriptional regulator
EXW35_18510	COG0010	Belongs to the arginase family
EXW35_18520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW35_18525	COG2986	histidine ammonia-lyase
EXW35_18535	COG2226	methyltransferase
EXW35_18565	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW35_18570	COG0785	Cytochrome C biogenesis protein
EXW35_18585	COG1473	amidohydrolase
EXW35_18590	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW35_18595	COG1131	(ABC) transporter
EXW35_18605	COG0583	DNA-binding transcription factor activity
EXW35_18615	COG1346	cytolysis
EXW35_18630	COG0730	response to heat
EXW35_18640	COG3409	Peptidoglycan-binding domain 1 protein
EXW35_18640	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW35_18660	COG1132	(ABC) transporter
EXW35_18665	COG1132	(ABC) transporter
EXW35_18670	COG3763	UPF0154 protein
EXW35_18690	COG3639	organic phosphonate transmembrane transporter activity
EXW35_18700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW35_18705	COG0737	Belongs to the 5'-nucleotidase family
EXW35_18715	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW35_18720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW35_18735	COG1695	Transcriptional regulator
EXW35_18740	COG0174	glutamine synthetase
EXW35_18745	COG0789	Transcriptional regulator
EXW35_18750	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW35_18755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW35_18760	COG2860	membrane
EXW35_18765	COG0464	growth
EXW35_18785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW35_18795	COG1388	LysM domain
EXW35_18795	COG3584	3D domain protein
EXW35_18800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW35_18800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW35_18800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW35_18805	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW35_18810	COG1349	DNA-binding transcription factor activity
EXW35_18815	COG1979	alcohol dehydrogenase
EXW35_18820	COG2322	membrane
EXW35_18830	COG1113	amino acid transport
EXW35_18850	COG1408	metallophosphoesterase
EXW35_18855	COG2116	formate transmembrane transporter activity
EXW35_18870	COG2217	Heavy metal translocating P-type atpase
EXW35_18875	COG2608	mercury ion transmembrane transporter activity
EXW35_18880	COG1937	Protein conserved in bacteria
EXW35_18910	COG4566	intracellular signal transduction
EXW35_18915	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW35_18920	COG2819	hydrolase of the alpha beta superfamily
EXW35_18925	COG1120	ATPase activity
EXW35_18930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW35_18935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW35_18940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW35_18945	COG0708	Exodeoxyribonuclease III
EXW35_18950	COG2169	Transcriptional regulator
EXW35_18955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW35_18960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW35_18970	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW35_18975	COG2364	Membrane
EXW35_18985	COG0346	lactoylglutathione lyase activity
EXW35_18990	COG3300	MHYT domain
EXW35_18990	COG5001	Diguanylate cyclase
EXW35_19030	COG1346	cytolysis
EXW35_19040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW35_19045	COG2267	carboxylic ester hydrolase activity
EXW35_19050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW35_19065	COG2188	Transcriptional regulator
EXW35_19070	COG2723	6-phospho-beta-galactosidase activity
EXW35_19075	COG0823	Involved in the tonB-independent uptake of proteins
EXW35_19080	COG3773	Cell wall hydrolase
EXW35_19090	COG1368	sulfuric ester hydrolase activity
EXW35_19095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW35_19105	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW35_19110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW35_19115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW35_19125	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW35_19130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW35_19135	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW35_19140	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW35_19140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW35_19150	COG2359	stage V sporulation protein S
EXW35_19155	COG1692	metallophosphoesterase
EXW35_19160	COG1418	mRNA catabolic process
EXW35_19165	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW35_19170	COG1058	Belongs to the CinA family
EXW35_19170	COG1546	Belongs to the CinA family
EXW35_19175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW35_19180	COG1426	Protein conserved in bacteria
EXW35_19195	COG0300	oxidoreductase activity
EXW35_19200	COG0612	Peptidase, M16
EXW35_19205	COG0612	Peptidase, M16
EXW35_19210	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW35_19215	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW35_19220	COG3845	ABC transporter
EXW35_19225	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW35_19230	COG2188	Transcriptional regulator
EXW35_19240	COG1674	ftsk spoiiie
EXW35_19250	COG0740	serine-type endopeptidase activity
EXW35_19255	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW35_19265	COG0527	aspartate kinase activity
EXW35_19270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW35_19275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW35_19280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW35_19285	COG1873	PFAM PRC-barrel domain
EXW35_19290	COG0612	Peptidase, M16
EXW35_19295	COG0726	polysaccharide deacetylase
EXW35_19300	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW35_19310	COG0196	riboflavin kinase activity
EXW35_19320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW35_19325	COG1550	Protein conserved in bacteria
EXW35_19330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW35_19335	COG1358	cellular component organization or biogenesis
EXW35_19340	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW35_19345	COG0195	Participates in both transcription termination and antitermination
EXW35_19350	COG0779	Required for maturation of 30S ribosomal subunits
EXW35_19360	COG0442	prolyl-tRNA aminoacylation
EXW35_19365	COG0750	zinc metalloprotease
EXW35_19375	COG4589	Belongs to the CDS family
EXW35_19385	COG0233	cytoplasmic translational termination
EXW35_19390	COG0528	UMP kinase activity
EXW35_19395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW35_19405	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW35_19410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW35_19415	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW35_19420	COG4974	Belongs to the 'phage' integrase family
EXW35_19425	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW35_19430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW35_19435	COG0758	DNA mediated transformation
EXW35_19440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW35_19445	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW35_19450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW35_19465	COG0335	large ribosomal subunit rRNA binding
EXW35_19470	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW35_19475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW35_19480	COG1837	Belongs to the UPF0109 family
EXW35_19490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW35_19500	COG0552	protein localization to endoplasmic reticulum
EXW35_19505	COG1196	nuclear chromosome segregation
EXW35_19510	COG0571	ribonuclease III activity
EXW35_19515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW35_19520	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_19525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW35_19530	COG0416	fatty acid biosynthetic process
EXW35_19535	COG1349	DNA-binding transcription factor activity
EXW35_19535	COG2050	protein possibly involved in aromatic compounds catabolism
EXW35_19540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW35_19545	COG1461	Dihydroxyacetone kinase
EXW35_19550	COG1302	Protein conserved in bacteria
EXW35_19565	COG1564	THIamine pyrophosphokinase
EXW35_19570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW35_19580	COG0515	serine threonine protein kinase
EXW35_19580	COG2815	serine threonine protein kinase
EXW35_19585	COG0631	protein serine/threonine phosphatase activity
EXW35_19590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW35_19595	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW35_19595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW35_19600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW35_19605	COG0242	peptide deformylase activity
EXW35_19610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW35_19615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW35_19620	COG1758	RNA polymerase activity
EXW35_19635	COG1561	YicC-like family, N-terminal region
EXW35_19640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW35_19650	COG0006	proline dipeptidase activity
EXW35_19670	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW35_19695	COG0167	dihydroorotate dehydrogenase activity
EXW35_19700	COG0543	2 iron, 2 sulfur cluster binding
EXW35_19705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW35_19715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW35_19720	COG0540	Belongs to the ATCase OTCase family
EXW35_19730	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW35_19735	COG0564	pseudouridine synthase activity
EXW35_19740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW35_19750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW35_19755	COG3599	regulation of cell shape
EXW35_19760	COG2302	S4 RNA-binding domain
EXW35_19765	COG0762	integral membrane protein
EXW35_19770	COG1799	cell septum assembly
EXW35_19775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW35_19785	COG1873	PFAM PRC-barrel domain
EXW35_19790	COG1191	sigma factor activity
EXW35_19795	COG1191	sigma factor activity
EXW35_19805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW35_19810	COG0849	cell division
EXW35_19815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW35_19830	COG0772	Belongs to the SEDS family
EXW35_19835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW35_19840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW35_19845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW35_19850	COG0768	penicillin binding
EXW35_19855	COG0768	penicillin binding
EXW35_19865	COG0275	rRNA processing
EXW35_19870	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW35_19875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW35_19880	COG0454	-acetyltransferase
EXW35_19890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW35_19895	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW35_19900	COG1323	Belongs to the UPF0348 family
EXW35_19905	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW35_19910	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW35_19915	COG3314	Sporulation integral membrane protein YlbJ
EXW35_19925	COG0742	ribosomal rna small subunit methyltransferase
EXW35_19935	COG4471	UPF0298 protein
EXW35_19940	COG3679	Belongs to the UPF0342 family
EXW35_19945	COG0406	alpha-ribazole phosphatase activity
EXW35_19960	COG2340	Cysteine-rich secretory protein family
EXW35_19970	COG3336	cytochrome c oxidase
EXW35_19995	COG0109	protoheme IX farnesyltransferase activity
EXW35_20000	COG1612	heme a metabolic process
EXW35_20005	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW35_20015	COG0772	Belongs to the SEDS family
EXW35_20020	COG4838	Belongs to the UPF0358 family
EXW35_20025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW35_20030	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW35_20040	COG4896	Protein conserved in bacteria
EXW35_20055	COG1217	gtp-binding protein TYPA
EXW35_20065	COG0483	inositol monophosphate 1-phosphatase activity
EXW35_20075	COG4493	Belongs to the UPF0637 family
EXW35_20080	COG4476	Belongs to the UPF0223 family
EXW35_20085	COG1982	Orn Lys Arg decarboxylase major
EXW35_20130	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW35_20135	COG0022	dehydrogenase e1 component
EXW35_20140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW35_20155	COG0561	phosphatase activity
EXW35_20165	COG5503	Protein of unknown function (DUF1447)
EXW35_20170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW35_20175	COG0569	domain protein
EXW35_20185	COG1473	amidohydrolase
EXW35_20190	COG2171	N-acyltransferase activity
EXW35_20195	COG0583	DNA-binding transcription factor activity
EXW35_20200	COG0517	IMP dehydrogenase activity
EXW35_20210	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW35_20220	COG4703	Protein of unknown function (DUF1797)
EXW35_20235	COG2200	EAL domain
EXW35_20240	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_20245	COG1408	metallophosphoesterase
EXW35_20290	COG2814	Major facilitator Superfamily
EXW35_20300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW35_20310	COG3209	COG3209 Rhs family protein
EXW35_20320	COG2205	protein histidine kinase activity
EXW35_20330	COG0436	Aminotransferase
EXW35_20335	COG1609	Transcriptional regulator
EXW35_20340	COG3833	ABC-type maltose transport systems, permease component
EXW35_20345	COG1175	transmembrane transport
EXW35_20350	COG2182	Extracellular solute-binding protein
EXW35_20360	COG0366	Alpha amylase catalytic
EXW35_20365	COG3842	ATPase activity
EXW35_20370	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_20410	COG0183	Belongs to the thiolase family
EXW35_20445	COG1695	Transcriptional regulator
EXW35_20450	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_20460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW35_20465	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW35_20470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW35_20475	COG0436	Aminotransferase
EXW35_20480	COG1850	ribulose-bisphosphate carboxylase activity
EXW35_20485	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW35_20490	COG0235	Class ii aldolase
EXW35_20495	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW35_20510	COG2084	Dehydrogenase
EXW35_20520	COG2199	diguanylate cyclase activity
EXW35_20525	COG0778	Nitroreductase
EXW35_20550	COG1263	PTS System
EXW35_20550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW35_20550	COG2190	(PTS) system
EXW35_20555	COG3711	transcriptional antiterminator
EXW35_20565	COG2188	Transcriptional regulator
EXW35_20570	COG0363	glucosamine-6-phosphate deaminase activity
EXW35_20575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW35_20585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW35_20595	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW35_20605	COG1547	Domain of unknown function (DUF309)
EXW35_20615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW35_20620	COG4086	secreted protein
EXW35_20625	COG0561	phosphatase activity
EXW35_20630	COG0697	spore germination
EXW35_20645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW35_20685	COG1686	Belongs to the peptidase S11 family
EXW35_20690	COG1725	Transcriptional regulator
EXW35_20695	COG1131	(ABC) transporter
EXW35_20720	COG1846	Transcriptional regulator
EXW35_20735	COG0598	Magnesium transport protein CorA
EXW35_20750	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW35_20760	COG4974	Belongs to the 'phage' integrase family
EXW35_20770	COG0735	belongs to the Fur family
EXW35_20775	COG1300	Membrane
EXW35_20795	COG0667	Aldo Keto reductase
EXW35_20800	COG0656	L-ascorbic acid biosynthetic process
EXW35_20805	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW35_20805	COG0456	acetyltransferase
EXW35_20815	COG4085	toxin activity
EXW35_20815	COG1525	nuclease
EXW35_20815	COG0737	Belongs to the 5'-nucleotidase family
EXW35_20820	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW35_20830	COG0596	Alpha beta hydrolase
EXW35_20835	COG2056	Na+-H+ antiporter family
EXW35_20840	COG1609	Transcriptional regulator
EXW35_20845	COG0456	acetyltransferase
EXW35_20850	COG1073	alpha beta
EXW35_20865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW35_20865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW35_20870	COG0307	riboflavin synthase, alpha
EXW35_20875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW35_20875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW35_20890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW35_20895	COG4106	trans-aconitate 2-methyltransferase activity
EXW35_20900	COG2226	methyltransferase
EXW35_20900	COG1073	alpha beta
EXW35_20905	COG0156	8-amino-7-oxononanoate synthase activity
EXW35_20915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW35_20925	COG1757	Na H antiporter
EXW35_20930	COG0737	Belongs to the 5'-nucleotidase family
EXW35_20940	COG1522	sequence-specific DNA binding
EXW35_20975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW35_20985	COG0300	oxidoreductase activity
EXW35_20990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW35_20995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW35_21000	COG1760	l-serine dehydratase
EXW35_21005	COG1760	l-serine dehydratase
EXW35_21015	COG1234	tRNA 3'-trailer cleavage
EXW35_21045	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW35_21050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW35_21060	COG1376	ErfK ybiS ycfS ynhG family protein
EXW35_21065	COG4129	membrane
EXW35_21070	COG1126	abc transporter atp-binding protein
EXW35_21075	COG0765	amino acid transport
EXW35_21080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW35_21095	COG2816	NAD+ diphosphatase activity
EXW35_21105	COG0772	Belongs to the SEDS family
EXW35_21115	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW35_21120	COG0022	dehydrogenase e1 component
EXW35_21125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW35_21130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW35_21135	COG3426	butyrate kinase activity
EXW35_21145	COG0280	phosphate acetyltransferase
EXW35_21155	COG3290	protein histidine kinase activity
EXW35_21155	COG3829	transcription factor binding
EXW35_21165	COG0584	glycerophosphoryl diester phosphodiesterase
EXW35_21170	COG3093	addiction module antidote protein HigA
EXW35_21210	COG0745	RESPONSE REGULATOR receiver
EXW35_21220	COG0750	zinc metalloprotease
EXW35_21225	COG0497	DNA recombination
EXW35_21230	COG1438	arginine binding
EXW35_21235	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW35_21240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW35_21245	COG0142	geranyltranstransferase activity
EXW35_21250	COG1722	exodeoxyribonuclease VII activity
EXW35_21255	COG1570	exodeoxyribonuclease VII activity
EXW35_21260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW35_21265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW35_21270	COG1302	Protein conserved in bacteria
EXW35_21275	COG0439	Biotin carboxylase
EXW35_21280	COG0511	ligase activity, forming carbon-carbon bonds
EXW35_21325	COG3854	ATPases associated with a variety of cellular activities
EXW35_21345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW35_21350	COG0006	proline dipeptidase activity
EXW35_21355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW35_21365	COG3872	metal-dependent enzyme
EXW35_21375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW35_21410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW35_21420	COG1609	Transcriptional regulator
EXW35_21430	COG2076	Multidrug Resistance protein
EXW35_21435	COG2076	Multidrug Resistance protein
EXW35_21470	COG1725	Transcriptional regulator
EXW35_21485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW35_21490	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW35_21495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW35_21500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW35_21530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW35_21555	COG4970	Tfp pilus assembly protein FimT
EXW35_21565	COG1459	type II secretion system
EXW35_21570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW35_21625	COG1410	methionine synthase
EXW35_21625	COG0646	methionine synthase
EXW35_21630	COG0646	methionine synthase
EXW35_21630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW35_21635	COG0626	cystathionine gamma-synthase activity
EXW35_21640	COG0626	cystathionine gamma-synthase activity
EXW35_21660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW35_21670	COG1940	carbohydrate kinase activity
EXW35_21675	COG4483	Protein conserved in bacteria
EXW35_21680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW35_21685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW35_21690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW35_21695	COG0704	Plays a role in the regulation of phosphate uptake
EXW35_21705	COG0581	inorganic phosphate transmembrane transporter activity
EXW35_21710	COG0573	inorganic phosphate transmembrane transporter activity
EXW35_21715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW35_21720	COG0768	penicillin binding
EXW35_21725	COG0477	Major facilitator Superfamily
EXW35_21730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW35_21750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW35_21755	COG0735	belongs to the Fur family
EXW35_21760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW35_21765	COG1121	(ABC) transporter
EXW35_21770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW35_21780	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW35_21795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW35_21800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW35_21805	COG2384	SAM-dependent methyltransferase
EXW35_21810	COG2010	Cytochrome c
EXW35_21815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW35_21820	COG0358	DNA primase activity
EXW35_21830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW35_21835	COG0517	IMP dehydrogenase activity
EXW35_21840	COG1381	Involved in DNA repair and RecF pathway recombination
EXW35_21850	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW35_21855	COG0295	cytidine deaminase activity
EXW35_21860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW35_21865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW35_21870	COG1480	7TM receptor with intracellular HD hydrolase
EXW35_21875	COG1702	phosphate starvation-inducible protein PhoH
EXW35_21890	COG1610	YqeY-like protein
EXW35_21895	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW35_21900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW35_21905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW35_21915	COG0484	heat shock protein binding
EXW35_21920	COG0443	Heat shock 70 kDa protein
EXW35_21930	COG1420	regulation of RNA biosynthetic process
EXW35_21935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW35_21940	COG1733	regulation of RNA biosynthetic process
EXW35_21945	COG0481	GTPase activity
EXW35_21955	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW35_21960	COG0268	Binds directly to 16S ribosomal RNA
EXW35_21965	COG1466	dna polymerase III delta subunit
EXW35_21975	COG2333	competence protein COMEC
EXW35_21975	COG0658	competence protein
EXW35_21980	COG2131	deaminase
EXW35_21985	COG1596	polysaccharide export
EXW35_21985	COG1555	photosystem II stabilization
EXW35_21990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW35_21995	COG2226	methyltransferase
EXW35_22000	COG0799	negative regulation of ribosome biogenesis
EXW35_22005	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW35_22010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW35_22015	COG1534	Rna-binding protein
EXW35_22020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW35_22025	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW35_22030	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW35_22040	COG0688	phosphatidylethanolamine metabolic process
EXW35_22050	COG1595	DNA-templated transcription, initiation
EXW35_22055	COG2357	RelA SpoT domain protein
EXW35_22065	COG1785	Belongs to the alkaline phosphatase family
EXW35_22075	COG2267	carboxylic ester hydrolase activity
EXW35_22110	COG1404	Belongs to the peptidase S8 family
EXW35_22115	COG3186	Phenylalanine-4-hydroxylase
EXW35_22120	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW35_22125	COG2514	catechol 2,3-dioxygenase activity
EXW35_22130	COG2259	Doxx family
EXW35_22170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW35_22180	COG1454	alcohol dehydrogenase
EXW35_22180	COG1012	belongs to the aldehyde dehydrogenase family
EXW35_22185	COG0626	cystathionine gamma-synthase activity
EXW35_22190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW35_22195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW35_22200	COG2226	methyltransferase
EXW35_22215	COG0768	penicillin binding
EXW35_22220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW35_22225	COG0572	uridine kinase
EXW35_22230	COG0826	peptidase U32
EXW35_22235	COG0826	peptidase U32
EXW35_22240	COG4122	O-methyltransferase activity
EXW35_22245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW35_22255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW35_22260	COG4472	Bacterial protein of unknown function (DUF965)
EXW35_22265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW35_22275	COG0628	permease
EXW35_22295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW35_22305	COG0482	sulfurtransferase activity
EXW35_22310	COG1104	cysteine desulfurase activity
EXW35_22315	COG1959	2 iron, 2 sulfur cluster binding
EXW35_22320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW35_22330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW35_22335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW35_22345	COG1490	D-aminoacyl-tRNA deacylase activity
EXW35_22350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW35_22355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW35_22360	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW35_22360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW35_22365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW35_22370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW35_22370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW35_22380	COG2244	polysaccharide biosynthetic process
EXW35_22385	COG2323	membrane
EXW35_22395	COG1862	Preprotein translocase
EXW35_22400	COG0343	queuine tRNA-ribosyltransferase activity
EXW35_22405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW35_22415	COG2255	four-way junction helicase activity
EXW35_22420	COG0632	four-way junction helicase activity
EXW35_22425	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW35_22455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW35_22460	COG0157	Belongs to the NadC ModD family
EXW35_22465	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW35_22470	COG1104	cysteine desulfurase activity
EXW35_22475	COG1827	regulation of RNA biosynthetic process
EXW35_22480	COG2258	MOSC domain
EXW35_22485	COG0077	Prephenate dehydratase
EXW35_22490	COG0577	efflux transmembrane transporter activity
EXW35_22495	COG0577	efflux transmembrane transporter activity
EXW35_22500	COG1136	(ABC) transporter
EXW35_22505	COG5002	protein histidine kinase activity
EXW35_22510	COG0745	RESPONSE REGULATOR receiver
EXW35_22515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW35_22520	COG3290	protein histidine kinase activity
EXW35_22530	COG2868	ribosomal protein
EXW35_22540	COG1530	ribonuclease E activity
EXW35_22545	COG1994	Peptidase M50
EXW35_22550	COG0739	heme binding
EXW35_22555	COG2894	cell division
EXW35_22560	COG0850	regulation of cytokinetic process
EXW35_22575	COG1077	Cell shape determining protein MreB Mrl
EXW35_22580	COG2003	Belongs to the UPF0758 family
EXW35_22585	COG0424	maF-like protein
EXW35_22600	COG0285	dihydrofolate synthase activity
EXW35_22615	COG1388	LysM domain
EXW35_22620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW35_22625	COG0113	porphobilinogen synthase activity
EXW35_22630	COG1587	Uroporphyrinogen-III synthase
EXW35_22635	COG0181	hydroxymethylbilane synthase activity
EXW35_22640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW35_22645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW35_22650	COG1846	Transcriptional regulator
EXW35_22655	COG1764	response to oxidative stress
EXW35_22660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW35_22670	COG0470	DNA polymerase III
EXW35_22670	COG1067	ATP-dependent peptidase activity
EXW35_22680	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW35_22710	COG0622	Phosphoesterase
EXW35_22720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW35_22725	COG5401	PFAM Sporulation and spore germination
EXW35_22735	COG0477	Major facilitator Superfamily
EXW35_22740	COG2197	response regulator
EXW35_22745	COG2233	PERMEase
EXW35_22750	COG0402	S-adenosylhomocysteine deaminase activity
EXW35_22755	COG1983	PspC domain protein
EXW35_22760	COG1396	sequence-specific DNA binding
EXW35_22765	COG0697	spore germination
EXW35_22775	COG1959	2 iron, 2 sulfur cluster binding
EXW35_22780	COG1668	transmembrane transport
EXW35_22785	COG4152	abc transporter atp-binding protein
EXW35_22790	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW35_22795	COG1360	Flagellar Motor Protein
EXW35_22800	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW35_22810	COG1876	peptidase activity
EXW35_22815	COG0824	Thioesterase
EXW35_22820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW35_22825	COG1053	succinate dehydrogenase
EXW35_22830	COG2009	succinate dehydrogenase
EXW35_22835	COG1719	4-vinyl reductase, 4VR
EXW35_22840	COG0322	excinuclease ABC activity
EXW35_22845	COG3118	belongs to the thioredoxin family
EXW35_22850	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW35_22855	COG2086	electron transfer activity
EXW35_22860	COG1024	Enoyl-CoA hydratase
EXW35_22865	COG1309	transcriptional regulator
EXW35_22870	COG0318	PFAM AMP-dependent synthetase and ligase
EXW35_22895	COG2318	DinB family
EXW35_22915	COG1131	(ABC) transporter
EXW35_22920	COG2205	protein histidine kinase activity
EXW35_22925	COG0745	RESPONSE REGULATOR receiver
EXW35_22930	COG4895	conserved protein (DUF2196)
EXW35_22935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW35_22945	COG4509	Sortase family
EXW35_22950	COG1120	ATPase activity
EXW35_22965	COG5386	Cell surface protein
EXW35_22975	COG5386	Cell surface protein
EXW35_22980	COG1114	Component of the transport system for branched-chain amino acids
EXW35_22990	COG1193	negative regulation of DNA recombination
EXW35_22995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW35_22995	COG1796	DNA polymerase
EXW35_23000	COG1286	toxin biosynthetic process
EXW35_23005	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW35_23010	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW35_23035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW35_23040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW35_23050	COG1418	mRNA catabolic process
EXW35_23070	COG2814	Major facilitator Superfamily
EXW35_23075	COG1566	PFAM secretion protein HlyD family protein
EXW35_23080	COG1309	transcriptional regulator
EXW35_23085	COG1363	Peptidase, m42
EXW35_23095	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW35_23110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW35_23120	COG1484	DNA-dependent DNA replication
EXW35_23125	COG3611	Membrane attachment protein
EXW35_23130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW35_23135	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW35_23140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW35_23145	COG0237	dephospho-CoA kinase activity
EXW35_23150	COG1971	Probably functions as a manganese efflux pump
EXW35_23160	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW35_23160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW35_23165	COG5002	protein histidine kinase activity
EXW35_23170	COG0745	RESPONSE REGULATOR receiver
EXW35_23185	COG0039	L-malate dehydrogenase activity
EXW35_23190	COG0538	isocitrate dehydrogenase activity
EXW35_23195	COG0372	Belongs to the citrate synthase family
EXW35_23210	COG0628	permease
EXW35_23215	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW35_23225	COG0205	6-phosphofructokinase activity
EXW35_23235	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW35_23240	COG1725	Transcriptional regulator
EXW35_23245	COG0281	malic enzyme
EXW35_23250	COG0587	DNA-directed DNA polymerase activity
EXW35_23265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW35_23285	COG4109	DRTGG domain
EXW35_23295	COG0006	proline dipeptidase activity
EXW35_23330	COG0662	Cupin 2, conserved barrel domain protein
EXW35_23340	COG1476	TRANSCRIPTIONal
EXW35_23355	COG1028	Short-chain dehydrogenase reductase Sdr
EXW35_23360	COG0589	response to stress
EXW35_23390	COG0137	argininosuccinate synthase activity
EXW35_23405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW35_23425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW35_23430	COG0827	DNA restriction-modification system
EXW35_23435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW35_23440	COG3874	Sporulation protein YtfJ
EXW35_23455	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW35_23465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW35_23480	COG1104	cysteine desulfurase activity
EXW35_23485	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW35_23500	COG1309	transcriptional regulator
EXW35_23505	COG1956	GAF domain-containing protein
EXW35_23510	COG0626	cystathionine gamma-synthase activity
EXW35_23515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW35_23540	COG1595	DNA-templated transcription, initiation
EXW35_23550	COG0110	maltose O-acetyltransferase activity
EXW35_23555	COG0456	acetyltransferase
EXW35_23560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW35_23565	COG0454	-acetyltransferase
EXW35_23570	COG0517	IMP dehydrogenase activity
EXW35_23575	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW35_23590	COG0745	RESPONSE REGULATOR receiver
EXW35_23595	COG5002	protein histidine kinase activity
EXW35_23600	COG0666	response to abiotic stimulus
EXW35_23610	COG1970	mechanosensitive ion channel activity
EXW35_23635	COG1609	Transcriptional regulator
EXW35_23645	COG1605	Chorismate mutase
EXW35_23645	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW35_23650	COG4851	CamS sex pheromone cAM373 precursor
EXW35_23655	COG3118	belongs to the thioredoxin family
EXW35_23665	COG2309	aminopeptidase activity
EXW35_23690	COG0697	spore germination
EXW35_23695	COG0789	Transcriptional regulator
EXW35_23700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW35_23710	COG1674	ftsk spoiiie
EXW35_23725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW35_23730	COG4848	Belongs to the UPF0354 family
EXW35_23735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW35_23740	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW35_23745	COG1363	Peptidase, m42
EXW35_23755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW35_23760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW35_23770	COG0510	thiamine kinase activity
EXW35_23775	COG1523	belongs to the glycosyl hydrolase 13 family
EXW35_23785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW35_23790	COG1349	DNA-binding transcription factor activity
EXW35_23795	COG1187	pseudouridine synthase activity
EXW35_23800	COG2244	polysaccharide biosynthetic process
EXW35_23805	COG2081	HI0933 family
EXW35_23810	COG2814	Major facilitator Superfamily
EXW35_23820	COG3832	glyoxalase III activity
EXW35_23840	COG1329	Transcriptional regulator
EXW35_23865	COG0314	molybdopterin synthase activity
EXW35_23870	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW35_23875	COG0303	'Molybdopterin
EXW35_23880	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW35_23885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW35_23890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW35_23915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW35_23925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW35_23965	COG0495	leucyl-tRNA aminoacylation
EXW35_23970	COG2814	Major facilitator Superfamily
EXW35_23975	COG0475	glutathione-regulated potassium exporter activity
EXW35_23980	COG0490	domain, Protein
EXW35_23985	COG0582	viral genome integration into host DNA
EXW35_24000	COG1136	(ABC) transporter
EXW35_24015	COG1242	4 iron, 4 sulfur cluster binding
EXW35_24020	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW35_24030	COG1131	(ABC) transporter
EXW35_24040	COG1794	racemase activity, acting on amino acids and derivatives
EXW35_24060	COG2267	carboxylic ester hydrolase activity
EXW35_24065	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW35_24070	COG0671	phosphoesterase, PA-phosphatase related
EXW35_24075	COG0438	transferase activity, transferring glycosyl groups
EXW35_24090	COG0746	molybdenum cofactor guanylyltransferase activity
EXW35_24110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW35_24115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW35_24145	COG5002	protein histidine kinase activity
EXW35_24150	COG3852	Histidine kinase
EXW35_24155	COG0753	catalase activity
EXW35_24160	COG2267	carboxylic ester hydrolase activity
EXW35_24170	COG1368	sulfuric ester hydrolase activity
EXW35_24180	COG4895	conserved protein (DUF2196)
EXW35_24195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW35_24200	COG1116	anion transmembrane transporter activity
EXW35_24205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW35_24230	COG0494	nUDIX hydrolase
EXW35_24270	COG2076	Multidrug Resistance protein
EXW35_24275	COG2076	Multidrug Resistance protein
EXW35_24280	COG0789	Transcriptional regulator
EXW35_24285	COG1854	S-ribosylhomocysteine lyase activity
EXW35_24295	COG0288	reversible hydration of carbon dioxide
EXW35_24300	COG1271	oxidase subunit
EXW35_24305	COG1294	oxidase, subunit
EXW35_24325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW35_24350	COG1842	Phage shock protein A
EXW35_24375	COG3859	Proton-coupled thiamine transporter YuaJ
EXW35_24380	COG5002	protein histidine kinase activity
EXW35_24385	COG0745	RESPONSE REGULATOR receiver
EXW35_24410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW35_24415	COG1597	lipid kinase activity
EXW35_24450	COG1136	(ABC) transporter
EXW35_24480	COG5002	protein histidine kinase activity
EXW35_24490	COG0586	Pfam SNARE associated Golgi protein
EXW35_24505	COG0577	efflux transmembrane transporter activity
EXW35_24510	COG1136	(ABC) transporter
EXW35_24515	COG3708	Transcriptional regulator
EXW35_24515	COG2207	Transcriptional regulator
EXW35_24525	COG1131	(ABC) transporter
EXW35_24535	COG5658	integral membrane protein
EXW35_24540	COG0640	Transcriptional regulator
EXW35_24545	COG0745	RESPONSE REGULATOR receiver
EXW35_24550	COG2205	protein histidine kinase activity
EXW35_24555	COG0577	efflux transmembrane transporter activity
EXW35_24560	COG0577	efflux transmembrane transporter activity
EXW35_24565	COG1136	(ABC) transporter
EXW35_24570	COG0577	efflux transmembrane transporter activity
EXW35_24585	COG2188	Transcriptional regulator
EXW35_24605	COG3964	amidohydrolase
EXW35_24625	COG4948	Mandelate Racemase Muconate Lactonizing
EXW35_24630	COG0318	PFAM AMP-dependent synthetase and ligase
EXW35_24635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW35_24640	COG0596	Alpha beta hydrolase
EXW35_24645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW35_24650	COG1169	isochorismate synthase
EXW35_24655	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW35_24660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW35_24665	COG1278	Cold shock
EXW35_24675	COG0789	Transcriptional regulator
EXW35_24685	COG0058	SHG alpha-glucan phosphorylase activity
EXW35_24695	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW35_24700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW35_24705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW35_24865	COG1285	pathogenesis
EXW35_24870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW35_24880	COG0166	Belongs to the GPI family
EXW35_24890	COG2155	Conserved Protein
EXW35_24895	COG1098	S1 RNA binding domain
EXW35_24900	COG0436	Aminotransferase
EXW35_24905	COG1522	sequence-specific DNA binding
EXW35_24910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW35_24920	COG2267	carboxylic ester hydrolase activity
EXW35_24930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW35_24945	COG5018	Exonuclease
EXW35_24950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW35_24970	COG2050	protein possibly involved in aromatic compounds catabolism
EXW35_24980	COG1268	BioY protein
EXW35_24985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW35_24990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW35_25000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW35_25005	COG3584	3D domain protein
EXW35_25020	COG1252	NADH dehydrogenase
EXW35_25025	COG0492	ferredoxin-NADP+ reductase activity
EXW35_25030	COG3708	Transcriptional regulator
EXW35_25045	COG1683	Conserved Protein
EXW35_25065	COG0316	Belongs to the HesB IscA family
EXW35_25070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW35_25075	COG4844	belongs to the
EXW35_25080	COG1252	NADH dehydrogenase
EXW35_25090	COG0390	transport system, permease component
EXW35_25095	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW35_25130	COG4837	Protein of unknown function (DUF1462)
EXW35_25135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW35_25145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW35_25150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW35_25165	COG1136	(ABC) transporter
EXW35_25165	COG0577	efflux transmembrane transporter activity
EXW35_25170	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW35_25180	COG0647	UMP catabolic process
EXW35_25190	COG2445	Protein of unknown function DUF86
EXW35_25195	COG1494	fructose-1,6-bisphosphatase
EXW35_25215	COG4470	Protein conserved in bacteria
EXW35_25225	COG0789	Transcriptional regulator
EXW35_25230	COG4377	Putative membrane peptidase family (DUF2324)
EXW35_25250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW35_25255	COG0739	heme binding
EXW35_25265	COG3377	Domain of unknown function (DUF1805)
EXW35_25270	COG0737	Belongs to the 5'-nucleotidase family
EXW35_25275	COG1695	Transcriptional regulator
EXW35_25285	COG0719	Fe-S assembly protein
EXW35_25290	COG0822	iron-sulfur transferase activity
EXW35_25295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW35_25300	COG0719	Fe-S assembly protein
EXW35_25305	COG0396	ATPase activity
EXW35_25310	COG1464	Belongs to the NlpA lipoprotein family
EXW35_25315	COG1464	Belongs to the NlpA lipoprotein family
EXW35_25320	COG2011	ABC-type metal ion transport system permease component
EXW35_25325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXW35_25335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW35_25340	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW35_25345	COG0509	glycine decarboxylation via glycine cleavage system
EXW35_25350	COG1393	Belongs to the ArsC family
EXW35_25390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW35_25405	COG1960	acyl-CoA dehydrogenase activity
EXW35_25410	COG0183	Belongs to the thiolase family
EXW35_25415	COG1024	Enoyl-CoA hydratase
EXW35_25415	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW35_25425	COG1686	Belongs to the peptidase S11 family
EXW35_25430	COG0506	proline dehydrogenase activity
EXW35_25440	COG0011	TIGRFAM Protein of
EXW35_25460	COG2814	Major facilitator Superfamily
EXW35_25465	COG0531	amino acid
EXW35_25490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW35_25525	COG0586	Pfam SNARE associated Golgi protein
EXW35_25535	COG1376	ErfK ybiS ycfS ynhG family protein
EXW35_25540	COG0745	RESPONSE REGULATOR receiver
EXW35_25545	COG5002	protein histidine kinase activity
EXW35_25555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW35_25565	COG0840	transmembrane signaling receptor activity
EXW35_25575	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW35_25580	COG3227	Zinc metalloprotease (Elastase)
EXW35_25585	COG1741	Belongs to the pirin family
EXW35_25600	COG0586	Pfam SNARE associated Golgi protein
EXW35_25605	COG0475	glutathione-regulated potassium exporter activity
EXW35_25610	COG0490	domain, Protein
EXW35_25615	COG1115	amino acid carrier protein
EXW35_25620	COG0783	Belongs to the Dps family
EXW35_25630	COG2318	DinB family
EXW35_25640	COG1611	Belongs to the LOG family
EXW35_25650	COG1528	Iron-storage protein
EXW35_25660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW35_25665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW35_25670	COG1115	amino acid carrier protein
EXW35_25675	COG1115	amino acid carrier protein
EXW35_25680	COG2910	NAD(P)H-binding
EXW35_25690	COG0656	L-ascorbic acid biosynthetic process
EXW35_25695	COG2814	Major facilitator Superfamily
EXW35_25700	COG1733	regulation of RNA biosynthetic process
EXW35_25710	COG1252	NADH dehydrogenase
EXW35_25730	COG0840	transmembrane signaling receptor activity
EXW35_25730	COG3290	protein histidine kinase activity
EXW35_25765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW35_25780	COG4224	UPF0291 protein
EXW35_25785	COG1335	isochorismatase
EXW35_25790	COG1522	sequence-specific DNA binding
EXW35_25800	COG1522	sequence-specific DNA binding
EXW35_25805	COG0288	reversible hydration of carbon dioxide
EXW35_25810	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW35_25840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW35_25860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW35_25870	COG0557	exoribonuclease II activity
EXW35_25875	COG1647	Serine aminopeptidase, S33
EXW35_25880	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW35_25885	COG1346	cytolysis
EXW35_25900	COG0148	phosphopyruvate hydratase activity
EXW35_25910	COG0149	triose-phosphate isomerase activity
EXW35_25915	COG0126	phosphoglycerate kinase activity
EXW35_25920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW35_25935	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW35_25970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW35_25985	COG2323	membrane
EXW35_25995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW35_26000	COG1481	regulation of sporulation
EXW35_26005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW35_26010	COG1660	Displays ATPase and GTPase activities
EXW35_26015	COG1051	belongs to the nudix hydrolase family
EXW35_26025	COG0492	ferredoxin-NADP+ reductase activity
EXW35_26030	COG0457	Tetratricopeptide repeat
EXW35_26035	COG0110	maltose O-acetyltransferase activity
EXW35_26040	COG0546	phosphoglycolate phosphatase activity
EXW35_26045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW35_26050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW35_26055	COG1950	PFAM Membrane protein of
EXW35_26060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW35_26080	COG0789	Transcriptional regulator
EXW35_26115	COG0583	DNA-binding transcription factor activity
EXW35_26120	COG0789	Transcriptional regulator
EXW35_26125	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW35_26130	COG0488	(ABC) transporter
EXW35_26140	COG1132	(ABC) transporter
EXW35_26145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW35_26150	COG0793	Belongs to the peptidase S41A family
EXW35_26150	COG3409	Peptidoglycan-binding domain 1 protein
EXW35_26155	COG2177	Part of the ABC transporter FtsEX involved in
EXW35_26160	COG2884	Cell division ATP-binding protein ftsE
EXW35_26195	COG1131	(ABC) transporter
EXW35_26230	COG1278	Cold shock
EXW35_26235	COG1040	competence protein
EXW35_26240	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW35_26245	COG0791	NLP P60 protein
EXW35_26245	COG1388	LysM domain
EXW35_26250	COG1733	regulation of RNA biosynthetic process
EXW35_26255	COG1307	EDD domain protein, DegV family
EXW35_26260	COG1739	Uncharacterized protein family UPF0029
EXW35_26265	COG1316	TRANSCRIPTIONal
EXW35_26270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW35_26275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW35_26280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW35_26290	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW35_26290	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW35_26310	COG1486	melibiose metabolic process
EXW35_26315	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW35_26320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW35_26340	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW35_26350	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW35_26355	COG1301	dicarboxylic acid transport
EXW35_26380	COG0583	DNA-binding transcription factor activity
EXW35_26385	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW35_26390	COG1271	oxidase subunit
EXW35_26395	COG1294	oxidase, subunit
EXW35_26400	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW35_26405	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW35_26410	COG1620	l-lactate permease
EXW35_26420	COG2389	metal-binding protein
EXW35_26435	COG1368	sulfuric ester hydrolase activity
EXW35_26445	COG1388	LysM domain
EXW35_26445	COG0791	NLP P60 protein
EXW35_26450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW35_26460	COG1215	transferase activity, transferring glycosyl groups
EXW35_26465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW35_26470	COG1388	LysM domain
EXW35_26470	COG3584	3D domain protein
EXW35_26485	COG4715	Zinc finger, swim domain protein
EXW35_26490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW35_26550	COG0577	efflux transmembrane transporter activity
EXW35_26555	COG1136	(ABC) transporter
EXW35_26580	COG3850	Histidine kinase
EXW35_26580	COG5002	protein histidine kinase activity
EXW35_26585	COG0745	RESPONSE REGULATOR receiver
EXW35_26590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW35_26595	COG1316	TRANSCRIPTIONal
EXW35_26605	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW35_26615	COG1215	transferase activity, transferring glycosyl groups
EXW35_26645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW35_26650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW35_26655	COG1086	Polysaccharide biosynthesis protein
EXW35_26660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW35_26665	COG4464	protein tyrosine phosphatase activity
EXW35_26670	COG0489	protein tyrosine kinase activity
EXW35_26675	COG3944	biosynthesis protein
EXW35_26685	COG1132	(ABC) transporter
EXW35_26715	COG0367	asparagine synthase
EXW35_26720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW35_26730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW35_26740	COG1216	Glycosyl transferase, family 2
EXW35_26775	COG1215	transferase activity, transferring glycosyl groups
EXW35_26795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW35_26795	COG0463	Glycosyl transferase, family 2
EXW35_26805	COG0438	transferase activity, transferring glycosyl groups
EXW35_26810	COG0438	transferase activity, transferring glycosyl groups
EXW35_26815	COG1086	Polysaccharide biosynthesis protein
EXW35_26820	COG0489	protein tyrosine kinase activity
EXW35_26825	COG3944	biosynthesis protein
EXW35_26830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW35_26835	COG0438	transferase activity, transferring glycosyl groups
EXW35_26840	COG1215	transferase activity, transferring glycosyl groups
EXW35_26840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW35_26850	COG1134	teichoic acid transport
EXW35_26855	COG1682	transport, permease protein
EXW35_26860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW35_26865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW35_26870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EXW35_26880	COG1609	Transcriptional regulator
EXW35_26890	COG0739	heme binding
EXW35_26905	COG3279	Response regulator of the LytR AlgR family
EXW35_26910	COG2385	sporulation resulting in formation of a cellular spore
EXW35_26925	COG4836	Membrane
EXW35_26930	COG1007	ATP synthesis coupled electron transport
EXW35_26935	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW35_26940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW35_26945	COG0713	ATP synthesis coupled electron transport
EXW35_26950	COG0839	Belongs to the complex I subunit 6 family
EXW35_26960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW35_26965	COG0649	NAD binding
EXW35_26970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW35_26975	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW35_26980	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW35_26985	COG5001	Diguanylate cyclase
EXW35_26985	COG3300	MHYT domain
EXW35_27000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW35_27005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW35_27010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW35_27015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW35_27020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW35_27025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW35_27035	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW35_27070	COG0698	ribose 5-phosphate isomerase
EXW35_27080	COG2190	(PTS) system
EXW35_27085	COG2259	Doxx family
EXW35_27090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW35_27100	COG1971	Probably functions as a manganese efflux pump
EXW35_27105	COG0009	L-threonylcarbamoyladenylate synthase
EXW35_27120	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW35_27125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW35_27130	COG1435	thymidine kinase activity
EXW35_27140	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW35_27145	COG1494	fructose-1,6-bisphosphatase
EXW35_27165	COG4821	SIS domain
EXW35_27170	COG0504	CTP synthase activity
EXW35_27185	COG1960	acyl-CoA dehydrogenase activity
EXW35_27190	COG1960	acyl-CoA dehydrogenase activity
EXW35_27195	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW35_27200	COG0183	Belongs to the thiolase family
EXW35_27205	COG0247	lactate metabolic process
EXW35_27205	COG2181	nitrate reductase activity
EXW35_27210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW35_27215	COG4294	response to UV
EXW35_27220	COG3300	MHYT domain
EXW35_27220	COG5001	Diguanylate cyclase
EXW35_27245	COG2197	response regulator
EXW35_27250	COG4585	Histidine kinase
EXW35_27255	COG0842	Transport permease protein
EXW35_27260	COG1131	(ABC) transporter
EXW35_27265	COG0024	Methionine aminopeptidase
EXW35_27270	COG2234	aminopeptidase activity
EXW35_27290	COG4506	Protein conserved in bacteria
EXW35_27295	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW35_27310	COG0010	Belongs to the arginase family
EXW35_27315	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW35_27320	COG2814	Major facilitator Superfamily
EXW35_27325	COG0789	Transcriptional regulator
EXW35_27330	COG0584	glycerophosphoryl diester phosphodiesterase
EXW35_27335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW35_27345	COG1994	Peptidase M50
EXW35_27355	COG1078	dGTPase activity
EXW35_27360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW35_27365	COG1120	ATPase activity
EXW35_27370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW35_27375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW35_27380	COG4844	belongs to the
EXW35_27395	COG0280	phosphate acetyltransferase
EXW35_27400	COG3253	May function as heme-dependent peroxidase
EXW35_27410	COG3773	Cell wall hydrolase
EXW35_27420	COG2363	Small membrane protein
EXW35_27435	COG2233	PERMEase
EXW35_27440	COG0561	phosphatase activity
EXW35_27445	COG2814	Major facilitator Superfamily
EXW35_27450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW35_27455	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW35_27460	COG1131	(ABC) transporter
EXW35_27465	COG2755	lipolytic protein G-D-S-L family
EXW35_27470	COG1609	Transcriptional regulator
EXW35_27480	COG0460	homoserine dehydrogenase
EXW35_27485	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW35_27490	COG2873	o-acetylhomoserine
EXW35_27505	COG2197	response regulator
EXW35_27510	COG4585	Histidine kinase
EXW35_27510	COG2203	Gaf domain
EXW35_27515	COG0351	phosphomethylpyrimidine kinase
EXW35_27520	COG3706	GGDEF domain
EXW35_27525	COG2879	small protein
EXW35_27530	COG1966	Carbon starvation protein
EXW35_27535	COG3279	Response regulator of the LytR AlgR family
EXW35_27540	COG0477	Major facilitator Superfamily
EXW35_27580	COG1607	acyl-coa hydrolase
EXW35_27585	COG1216	Glycosyl transferase, family 2
EXW35_27595	COG1216	Glycosyl transferase, family 2
EXW35_27605	COG4485	Bacterial membrane protein, YfhO
EXW35_27610	COG0463	Glycosyl transferase, family 2
EXW35_27625	COG1309	transcriptional regulator
EXW35_27630	COG0488	(ABC) transporter
EXW35_27635	COG1309	transcriptional regulator
EXW35_27640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW35_27645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW35_27645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW35_27650	COG0628	permease
EXW35_27660	COG1380	Effector of murein hydrolase LrgA
EXW35_27665	COG3279	Response regulator of the LytR AlgR family
EXW35_27670	COG3275	phosphorelay sensor kinase activity
EXW35_27675	COG2814	Major facilitator Superfamily
EXW35_27680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW35_27685	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW35_27695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW35_27720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW35_27725	COG1272	protein, Hemolysin III
EXW35_27750	COG1164	Oligoendopeptidase f
EXW35_27760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW35_27770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW35_27775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW35_27780	COG4853	Protein conserved in bacteria
EXW35_27790	COG5002	protein histidine kinase activity
EXW35_27795	COG0745	RESPONSE REGULATOR receiver
EXW35_27825	COG0305	Participates in initiation and elongation during chromosome replication
EXW35_27830	COG0359	binds to the 23S rRNA
EXW35_27835	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW35_27840	COG4241	membrane
EXW35_27850	COG0629	single-stranded DNA binding
EXW35_27855	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW35_27860	COG0012	GTP binding
EXW35_27865	COG4481	Protein conserved in bacteria
EXW35_27870	COG0668	transmembrane transport
EXW35_27880	COG1475	DNA binding
EXW35_27885	COG1192	Involved in chromosome partitioning
EXW35_27890	COG1475	DNA binding
EXW35_27895	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW35_27900	COG0445	tRNA wobble uridine modification
EXW35_27905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW35_27910	COG1847	R3H domain protein
EXW35_27915	COG0706	membrane insertase activity
EXW35_27920	COG0594	ribonuclease P activity
EXW35_27925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW35_27935	COG3118	belongs to the thioredoxin family
EXW35_27960	COG0582	viral genome integration into host DNA
EXW35_28030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW35_28080	COG4974	Belongs to the 'phage' integrase family
EXW35_28130	COG4974	Belongs to the 'phage' integrase family
EXW35_28140	COG0768	penicillin binding
EXW35_28170	COG2732	(Barnase) inhibitor
EXW35_28280	COG1136	(ABC) transporter
EXW35_28285	COG0577	efflux transmembrane transporter activity
EXW35_28300	COG0741	lytic transglycosylase activity
EXW35_28310	COG0772	Belongs to the SEDS family
EXW35_28385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW35_28390	COG5566	PFAM Mor transcription activator
EXW35_28485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW35_28495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW35_28520	COG1388	LysM domain
EXW35_28545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW35_28550	COG0596	Alpha beta hydrolase
EXW35_28555	COG2707	UPF0756 membrane protein
EXW35_28565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW35_28600	COG2814	Major facilitator Superfamily
EXW35_28610	COG1476	TRANSCRIPTIONal
EXW35_28640	COG0825	malonyl-CoA metabolic process
EXW35_28680	COG2226	methyltransferase
EXW35_28695	COG4555	ABC transporter
EXW35_28715	COG0720	synthase
EXW35_28725	COG0302	gtp cyclohydrolase
EXW35_28810	COG1522	sequence-specific DNA binding
EXW35_28815	COG0519	Catalyzes the synthesis of GMP from XMP
EXW35_28840	COG2002	toxin-antitoxin pair type II binding
EXW35_28860	COG1595	DNA-templated transcription, initiation
EXW35_28915	COG1216	Glycosyl transferase, family 2
EXW35_28940	COG2801	Transposase and inactivated derivatives
EXW35_28950	COG0582	viral genome integration into host DNA
EXW35_28960	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EXW35_28960	COG3266	domain, Protein
EXW35_28960	COG4932	domain protein
EXW35_28995	COG2868	ribosomal protein
EXW35_29005	COG1923	regulation of RNA biosynthetic process
EXW35_29035	COG2312	Erythromycin esterase
EXW35_29135	COG0791	NLP P60 protein
EXW35_29135	COG3883	PFAM NLP P60 protein
EXW35_29260	COG1192	Involved in chromosome partitioning
EXW35_29410	COG0741	lytic transglycosylase activity
EXW35_29410	COG0791	NLP P60 protein
EXW35_29435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW35_29450	COG0596	Alpha beta hydrolase
EXW35_29490	COG3773	Cell wall hydrolase
EXW35_29520	COG0741	lytic transglycosylase activity
EXW35_29525	COG5002	protein histidine kinase activity
EXW35_29530	COG0745	RESPONSE REGULATOR receiver
EXW35_29535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW35_29540	COG0577	efflux transmembrane transporter activity
EXW35_29545	COG1136	(ABC) transporter
EXW35_29630	COG2732	(Barnase) inhibitor
EXW35_29730	COG4842	Belongs to the WXG100 family
EXW35_29750	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW35_29755	COG1674	ftsk spoiiie
EXW35_29785	COG5444	nuclease activity
EXW35_30030	COG2801	Transposase and inactivated derivatives
EXW35_30080	COG0583	DNA-binding transcription factor activity
EXW35_30085	COG1942	4-Oxalocrotonate Tautomerase
EXW35_30095	COG1073	alpha beta
EXW35_30140	COG2720	vancomycin resistance protein
EXW35_30175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW35_30175	COG2755	lipolytic protein G-D-S-L family
EXW35_30195	COG0756	dUTP diphosphatase activity
EXW35_30245	COG0463	Glycosyl transferase, family 2
EXW35_30250	COG0463	Glycosyl transferase, family 2
EXW35_30255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW35_30260	COG1086	Polysaccharide biosynthesis protein
EXW35_30265	COG1088	dTDP-glucose 4,6-dehydratase activity
EXW35_30270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW35_30275	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW35_30290	COG2089	acid synthase
EXW35_30295	COG4641	Protein conserved in bacteria
EXW35_30365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW35_30460	COG0024	Methionine aminopeptidase
EXW35_30470	COG2002	toxin-antitoxin pair type II binding
EXW35_30480	COG1923	regulation of RNA biosynthetic process
EXW35_30550	COG2814	Major facilitator Superfamily
EXW35_30575	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EXW35_30620	COG0582	viral genome integration into host DNA
EXW35_30770	COG4974	Belongs to the 'phage' integrase family
EXW35_30845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW35_30900	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXW35_30915	COG2002	toxin-antitoxin pair type II binding
EXW35_30945	COG0658	competence protein
EXW35_30945	COG2333	competence protein COMEC
EXW35_31000	COG3409	Peptidoglycan-binding domain 1 protein
EXW35_31000	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW35_31090	COG0577	efflux transmembrane transporter activity
EXW35_31095	COG1136	(ABC) transporter
EXW35_31120	COG3227	Zinc metalloprotease (Elastase)
EXW35_31125	COG2373	Large extracellular alpha-helical protein
EXW35_31130	COG3409	Peptidoglycan-binding domain 1 protein
EXW35_31130	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW35_31165	COG2312	Erythromycin esterase
EXW35_31205	COG2755	lipolytic protein G-D-S-L family
EXW35_31205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW35_31215	COG3331	DNA recombination
EXW35_31280	COG2801	Transposase and inactivated derivatives
EXW35_31365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW35_31390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW35_31555	COG0551	DNA topoisomerase type I activity
EXW35_31555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW35_31575	COG0024	Methionine aminopeptidase
EXW35_31590	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW35_31625	COG0463	Glycosyl transferase, family 2
EXW35_31650	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW35_31655	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW35_31660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW35_31665	COG0438	transferase activity, transferring glycosyl groups
EXW35_31685	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW35_31690	COG0438	transferase activity, transferring glycosyl groups
EXW35_31695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW35_31795	COG3773	Cell wall hydrolase
EXW35_31880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW35_31890	COG1132	(ABC) transporter
EXW35_31905	COG2814	Major facilitator Superfamily
EXW35_31930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW35_31940	COG0582	viral genome integration into host DNA
EXW35_32000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW35_32025	COG0457	Tetratricopeptide repeat
EXW35_32035	COG4166	transmembrane transport
EXW35_32095	COG0384	phenazine biosynthesis protein PhzF
EXW35_32130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins