locus-tag class description DN409_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DN409_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DN409_00015 ENOG410848D S4 domain protein YaaA DN409_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DN409_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DN409_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DN409_00075 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) DN409_00080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) DN409_00100 ENOG4105ZMH deoxynucleoside kinase DN409_00110 ENOG4105GTG Isochorismatase DN409_00115 ENOG4108Z6B deaminase DN409_00125 ENOG4105C6E dna polymerase iii DN409_00130 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DN409_00135 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DN409_00145 ENOG41067KS pro-sigma K processing DN409_00180 ENOG4105CXN decarboxylase DN409_00185 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DN409_00190 ENOG4105FA2 dna polymerase iii DN409_00195 ENOG4105MA4 psp1 domain protein DN409_00205 ENOG41060K3 Methyltransferase DN409_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DN409_00220 ENOG4105KRN Transcriptional regulator, abrb family DN409_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DN409_00230 ENOG4105F8V Hydrolase, tatD family DN409_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DN409_00240 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DN409_00245 ENOG4105XFA sporulation peptidase YabG DN409_00250 ENOG4105W42 Veg protein DN409_00260 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DN409_00265 ENOG4105DFT pur operon repressor DN409_00270 ENOG4105KME endoribonuclease L-psp DN409_00280 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DN409_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DN409_00300 ENOG4108JA2 transcriptioN-repair coupling factor DN409_00305 ENOG4108M14 stage v sporulation protein t DN409_00315 ENOG4108IY2 MazG family DN409_00320 ENOG41082I2 s4 domain protein DN409_00325 ENOG4105VYY sporulation protein yabp DN409_00340 ENOG41060GV RNA binding s1 domain protein DN409_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DN409_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase DN409_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DN409_00375 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) DN409_00380 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DN409_00385 ENOG4105C6T cysteine synthase DN409_00390 ENOG4105CRQ synthase (Component I) DN409_00395 ENOG4105DDQ anthranilate synthase DN409_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DN409_00405 ENOG4105EEI dihydropteroate synthase DN409_00410 ENOG4105KRF dihydroneopterin aldolase DN409_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DN409_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DN409_00430 ENOG4105CRK lysyL-tRNA synthetase DN409_00520 ENOG4108Z0C Uvrb UvrC protein DN409_00535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DN409_00540 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) DN409_00545 ENOG4105CTP PilT protein domain protein DN409_00550 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DN409_00560 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DN409_00565 ENOG4105D7W serine acetyltransferase DN409_00570 ENOG4105C8N cysteinyl-tRNA synthetase DN409_00580 ENOG4105C2N RNA methyltransferase TrmH family group 3 DN409_00585 ENOG4105M0M Tetracycline resistance protein DN409_00590 ENOG4105QIV RNA polymerase DN409_00605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DN409_00615 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) DN409_00620 ENOG4108VZM 50s ribosomal protein L10 DN409_00625 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) DN409_00630 ENOG4107Y49 methyltransferase DN409_00635 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DN409_00640 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DN409_00645 ENOG4105XPM ribosomal protein DN409_00655 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DN409_00660 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DN409_00665 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DN409_00680 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DN409_00690 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DN409_00695 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) DN409_00700 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DN409_00710 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DN409_00715 ENOG41082SA 50s ribosomal protein l29 DN409_00720 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DN409_00725 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DN409_00730 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) DN409_00735 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DN409_00745 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DN409_00750 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DN409_00755 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DN409_00765 ENOG4105VPB 50S ribosomal protein L30 DN409_00770 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DN409_00775 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DN409_00785 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DN409_00795 ENOG41067V7 50S ribosomal protein L36 DN409_00805 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DN409_00825 ENOG4108JJB ABC transporter DN409_00830 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DN409_00835 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DN409_00840 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DN409_00845 ENOG4108UJD 30S ribosomal protein S9 DN409_00860 ENOG4105D1F ATP-binding protein DN409_00875 ENOG4108NMV polysaccharide deacetylase DN409_00955 ENOG4105C8B TIGR00159 family DN409_00960 ENOG4107U5W ybbr family DN409_00965 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DN409_00970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DN409_00980 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DN409_01005 ENOG4108PSK reductase DN409_01010 ENOG4108UMI ABC transporter, permease DN409_01020 ENOG4105D01 (LipO)protein DN409_01035 ENOG4105IQ5 FAD linked oxidase domain protein DN409_01050 ENOG4105C2C drug resistance transporter, Bcr CflA DN409_01070 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DN409_01075 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN409_01080 ENOG4105C3U ABC transporter DN409_01085 ENOG4108JQ7 (ABC) transporter DN409_01105 ENOG4108J59 Extracellular solute-binding protein, family 5 DN409_01110 ENOG4108J59 Extracellular solute-binding protein, family 5 DN409_01120 ENOG4105II7 pyrroline-5-carboxylate reductase DN409_01125 ENOG4106Z1T Nicotinamide Mononucleotide Transporter DN409_01135 ENOG4105E0C molybdate abc transporter DN409_01140 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DN409_01145 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DN409_01175 ENOG4105F6E Acyl-transferase DN409_01195 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DN409_01210 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DN409_01230 ENOG4105C5H ABC transporter DN409_01235 ENOG4105BZU Histidine kinase DN409_01245 ENOG4105CJ1 ABC, transporter DN409_01250 ENOG41090VJ ABC-2 type transporter DN409_01255 ENOG4108KYE ABC-2 type transporter DN409_01265 ENOG4105DEF Extracellular solute-binding protein, family 5 DN409_01275 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN409_01280 ENOG4105C3U ABC transporter DN409_01285 ENOG4108JQ7 (ABC) transporter DN409_01290 ENOG410667J hydrolase DN409_01320 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DN409_01325 ENOG4105ERH Fumarylacetoacetate hydrolase DN409_01335 ENOG4105CUB amino acid DN409_01340 ENOG4108SC4 )-transporter DN409_01345 ENOG4105CPF Cell wall formation (By similarity) DN409_01350 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DN409_01370 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DN409_01375 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DN409_01380 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DN409_01390 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DN409_01495 ENOG4105K8N protein family UPF0079, ATPase DN409_01500 ENOG41072GX Peptidase M22 Glycoprotease DN409_01505 ENOG410801F ribosomal-protein-alanine acetyltransferase DN409_01515 ENOG4105C5H ABC transporter DN409_01530 ENOG4108TYN CAAX amino terminal protease family protein DN409_01535 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DN409_01540 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DN409_01545 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DN409_01550 ENOG4105C7N Xanthine uracil vitamin C permease DN409_01560 ENOG4105BZU Histidine kinase DN409_01590 ENOG4107ZXU DSBA oxidoreductase DN409_01620 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN409_01640 ENOG4108SHN Glycosyl transferase, family 2 DN409_01665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN409_01690 ENOG4105SX7 Transporter DN409_01720 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DN409_01725 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DN409_01730 ENOG4105C83 adenylosuccinate lyase DN409_01735 ENOG4105C8V SAICAR synthetase DN409_01740 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DN409_01745 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I DN409_01750 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii DN409_01760 ENOG4105CXB phosphoribosylaminoimidazole synthetase DN409_01765 ENOG4108V3E phosphoribosylglycinamide formyltransferase DN409_01770 ENOG4105DC1 bifunctional purine biosynthesis protein purh DN409_01775 ENOG4105C12 Phosphoribosylglycinamide synthetase DN409_01805 ENOG4105C4R Atp-dependent dna helicase DN409_01810 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DN409_01825 ENOG4105C26 Dehydrogenase DN409_01830 ENOG4108W2Y isochorismatase DN409_01840 ENOG4108UMI ABC transporter, permease DN409_01845 ENOG4105D01 (LipO)protein DN409_01865 ENOG41067TZ transcriptional regulator, MarR family DN409_01870 ENOG4107I77 yiaA/B two helix domain DN409_01880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DN409_01885 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DN409_01890 ENOG4105CBD Diacylglycerol kinase DN409_01900 ENOG4108JPW Aminotransferase DN409_01910 ENOG4105C26 Dehydrogenase DN409_01915 ENOG4105KPY Small multidrug resistance protein DN409_01935 ENOG4105D9N nucleoside DN409_01940 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DN409_01950 ENOG4105BZU Histidine kinase DN409_01955 ENOG4108W15 Protein of unknown function (DUF1456) DN409_01970 ENOG4105DTQ mandelate racemase muconate lactonizing DN409_01980 ENOG4105DFD Na H antiporter DN409_02000 ENOG4105D3R alkyl hydroperoxide reductase DN409_02005 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DN409_02010 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DN409_02015 ENOG4107W7X Aldolase DN409_02020 ENOG4105EHG Permease protein DN409_02025 ENOG4105DQ5 transport system permease protein DN409_02030 ENOG4108V5C ABC transporter DN409_02040 ENOG4105CAY ferredoxin--nadp reductase DN409_02060 ENOG4106UIA DN409_02065 ENOG4106UIA DN409_02080 ENOG4105BZU Histidine kinase DN409_02100 ENOG410756H nucleotidyltransferase DN409_02115 ENOG4105E5Q amino acid AbC transporter DN409_02120 ENOG4105EAB amino acid AbC transporter DN409_02130 ENOG4105C8Q Methyl-accepting chemotaxis DN409_02135 ENOG4105DNP FAD linked oxidase domain protein DN409_02145 ENOG4105CI1 PTS System DN409_02160 ENOG4105C9U ATP-dependent DNA helicase RecQ DN409_02165 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase DN409_02175 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DN409_02190 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DN409_02195 ENOG4105D2X ABC transporter substrate-binding protein DN409_02205 ENOG4105C5H ABC transporter DN409_02240 ENOG4105DEU major facilitator superfamily DN409_02270 ENOG4108N0M stress protein DN409_02275 ENOG4106FN3 tellurium resistance protein DN409_02280 ENOG4106FN3 tellurium resistance protein DN409_02285 ENOG4107TS3 membrane protein, TerC DN409_02290 ENOG4108TTB tellurium resistance protein DN409_02310 ENOG4105KJF protein tyrosine phosphatase DN409_02320 ENOG4107U9T Pfam:Ribonuclease_BN DN409_02325 ENOG4105C59 p-type ATPase DN409_02330 ENOG4108IPJ Membrane DN409_02355 ENOG4107ZTW SNARE associated Golgi DN409_02370 ENOG410606W general stress protein DN409_02375 ENOG4105UPD Calcium Proton DN409_02415 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DN409_02425 ENOG4108JUB Transcriptional regulator DN409_02435 ENOG4108IQI permease DN409_02460 ENOG4105CSV Glutaminase DN409_02475 ENOG4108A04 Beta-lactamase DN409_02490 ENOG4107R51 Glycosyl transferase, family 2 DN409_02495 ENOG4107QQG Dehydrogenase DN409_02500 ENOG4105C3I Nad-dependent epimerase dehydratase DN409_02505 ENOG4105CKK Glycosyl transferase, family 2 DN409_02520 ENOG4105F1A Pyruvate formate-lyase DN409_02525 ENOG4108QBV Monogalactosyldiacylglycerol synthase DN409_02540 ENOG4105CI2 imidazolone-5-propionate hydrolase DN409_02545 ENOG4105ECP epimerase DN409_02575 ENOG41067AE Membrane-bound metal-dependent hydrolase DN409_02580 ENOG4105CEN a g-specific adenine glycosylase DN409_02605 ENOG4105BZ1 (ABC) transporter DN409_02610 ENOG4107NBY Membrane DN409_02615 ENOG4105CBC glutamate synthase DN409_02625 ENOG4108IUW ABC transporter DN409_02645 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN409_02650 ENOG4105G5W regulator Fur family DN409_02770 ENOG4108JQC penicillin-binding protein 1A DN409_02775 ENOG4107ZQN disulfide bond DN409_02785 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DN409_02795 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DN409_02800 ENOG4105BZU Histidine kinase DN409_02805 ENOG4105CYN Serine protein kinase DN409_02810 ENOG4106AKX UPF0229 protein DN409_02830 ENOG4105DZ6 Band 7 protein DN409_02840 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DN409_02845 ENOG4108V9W transcriptional regulatory protein DN409_02850 ENOG4105D4T Citrate transporter DN409_02875 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DN409_02880 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN409_02885 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DN409_02890 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DN409_02895 ENOG4105BZ7 extracellular solute-binding protein family 1 DN409_02900 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DN409_02905 ENOG4108STX response regulator DN409_02910 ENOG4105US7 Histidine kinase DN409_02935 ENOG4108MRH transcriptional regulatory protein DN409_02945 ENOG4105C6K Malic enzyme DN409_02955 ENOG4108UZ3 Transporter DN409_02960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN409_02970 ENOG4105BZU Histidine kinase DN409_02975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_02980 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DN409_02985 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DN409_02990 ENOG4108JB9 formate dehydrogenase DN409_03010 ENOG4105CUB amino acid DN409_03025 ENOG4105C59 p-type ATPase DN409_03030 ENOG4105DAP Nicotinate phosphoribosyltransferase DN409_03060 ENOG41073R8 VanW family DN409_03065 ENOG4108KGH TRANSCRIPTIONal DN409_03070 ENOG4105D9N nucleoside DN409_03075 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DN409_03080 ENOG4105C37 (CBS) domain DN409_03085 ENOG4108IJ0 Aspartate ammonia-lyase DN409_03090 ENOG4105DAA L-lactate DN409_03095 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN409_03115 ENOG4105DUX Transporter DN409_03120 ENOG4108MES Periplasmic binding protein DN409_03125 ENOG4105DQ5 transport system permease protein DN409_03130 ENOG4108IHU transport system permease protein DN409_03135 ENOG4105E0A ABC, transporter DN409_03140 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) DN409_03150 ENOG4105EXW epimerase dehydratase DN409_03160 ENOG4107T89 von Willebrand factor, type A DN409_03165 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DN409_03170 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DN409_03180 ENOG4105BZU Histidine kinase DN409_03185 ENOG4105D5Q Arginine ornithine antiporter DN409_03190 ENOG4107414 GntR family transcriptional regulator DN409_03200 ENOG4105C5Y PTS System DN409_03205 ENOG4105CG3 alpha amylase, catalytic region DN409_03220 ENOG4105E1K spore germination protein DN409_03225 ENOG4108XG2 Histidine kinase DN409_03230 ENOG4105WH1 Two component transcriptional regulator luxr family DN409_03235 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DN409_03250 ENOG4105CRN Aminoglycoside phosphotransferase DN409_03255 ENOG4105BZG amino acid carrier protein DN409_03260 ENOG4105CDA abc transporter atp-binding protein DN409_03265 ENOG4105CT1 (ABC) transporter DN409_03270 ENOG4105EAD ABC transporter DN409_03275 ENOG4105DRP amino acid AbC transporter DN409_03280 ENOG4108IQI permease DN409_03310 ENOG4105D29 Helix-turn-helix type 11 domain protein DN409_03315 ENOG4105NAE bifunctional deaminase-reductase domain protein DN409_03320 ENOG4105BZU Histidine kinase DN409_03335 ENOG4105CHH sulfate transporter DN409_03340 ENOG41068KF Universal stress protein DN409_03360 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DN409_03365 ENOG4108JQ7 (ABC) transporter DN409_03375 ENOG4105CXY transporter DN409_03380 ENOG41067TZ transcriptional regulator, MarR family DN409_03385 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN409_03390 ENOG4105ETE Transcriptional regulator (LacI family DN409_03395 ENOG4108RVA ribokinase DN409_03400 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DN409_03405 ENOG4105C2J ABC transporter DN409_03410 ENOG4105CNN ABC, transporter DN409_03415 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DN409_03420 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DN409_03440 ENOG4105C6X Major Facilitator DN409_03485 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DN409_03490 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DN409_03495 ENOG41069ER domain protein DN409_03500 ENOG4105VZ8 Transcriptional regulator DN409_03505 ENOG4107D63 DN409_03520 ENOG4105DUX Transporter DN409_03540 ENOG4105C85 amino acid DN409_03545 ENOG4105C7N Xanthine uracil vitamin C permease DN409_03560 ENOG4105MA6 gCN5-related N-acetyltransferase DN409_03585 ENOG4105CCU oxidase (Subunit III) DN409_03590 ENOG4105BZ9 Cytochrome C oxidase, subunit I DN409_03595 ENOG4105E2S oxidase) subunit II DN409_03600 ENOG4108IQI permease DN409_03615 ENOG4106CAD Protein of unknown function (DUF3311) DN409_03620 ENOG4105E1V na solute symporter DN409_03635 ENOG4108NHD germination protein DN409_03640 ENOG4105CE1 Ferrous iron transport protein b DN409_03645 ENOG4105CE1 Ferrous iron transport protein b DN409_03655 ENOG4105CVA phosphate DN409_03660 ENOG4105C8U phosphate abc transporter DN409_03665 ENOG4105E2Z phosphate ABC transporter (Permease DN409_03795 ENOG41080XQ Signal transduction protein with cbs domains DN409_03810 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DN409_03815 ENOG4105ETU transcriptional activator (TenA DN409_03825 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DN409_03835 ENOG4108VEU Thiamine monophosphate synthase DN409_03840 ENOG41080HI glycine oxidase DN409_03855 ENOG4105D06 uba thif-type nad fad binding protein DN409_03860 ENOG4105DWF phosphomethylpyrimidine kinase DN409_03885 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DN409_03890 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DN409_03895 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) DN409_03910 ENOG4108INS Transcriptional regulator DN409_03920 ENOG4105CNN ABC, transporter DN409_03925 ENOG4105C2J ABC transporter DN409_03935 ENOG4105C7N Xanthine uracil vitamin C permease DN409_03945 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DN409_03960 ENOG4105K63 Thioredoxin DN409_03980 ENOG4108B31 Spore germination protein DN409_04000 ENOG4107Y03 Nitroreductase DN409_04005 ENOG4105ED1 spovr family DN409_04030 ENOG4105XTG Pfam:DUF156 DN409_04035 ENOG4105VFE sira family DN409_04040 ENOG4107TPS domain protein DN409_04045 ENOG4105VFE sira family DN409_04050 ENOG4105VFE sira family DN409_04055 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DN409_04060 ENOG41087NI Sulfite exporter TauE/SafE DN409_04070 ENOG4108KGH TRANSCRIPTIONal DN409_04085 ENOG4105EE1 crotonyl-CoA reductase DN409_04105 ENOG4105EMD TRANSCRIPTIONal DN409_04110 ENOG4105VCP PTS System DN409_04115 ENOG4105VZJ PTS System DN409_04135 ENOG41069ER domain protein DN409_04140 ENOG4107RBB ABC transporter, permease DN409_04145 ENOG4105C19 ABC transporter DN409_04180 ENOG4105WEF catalase DN409_04210 ENOG4107T5V SNARE associated Golgi DN409_04240 ENOG4105CUB amino acid DN409_04245 ENOG4107RWR Sodium hydrogen exchanger DN409_04255 ENOG4106KNT transcriptional regulator DN409_04260 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DN409_04295 ENOG4108PCN EamA-like transporter family DN409_04300 ENOG4108YXU transcriptional regulator AsnC family DN409_04310 ENOG4108IXY short-chain dehydrogenase reductase DN409_04320 ENOG4105KPY Small multidrug resistance protein DN409_04325 ENOG4105KPY Small multidrug resistance protein DN409_04360 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DN409_04365 ENOG4105E5W Transporter DN409_04375 ENOG4107RKG DJ-1/PfpI family DN409_04385 ENOG4105D5Q Arginine ornithine antiporter DN409_04390 ENOG4105C26 Dehydrogenase DN409_04405 ENOG4105BZ1 (ABC) transporter DN409_04410 ENOG4105BZ1 (ABC) transporter DN409_04420 ENOG4105DRP amino acid AbC transporter DN409_04425 ENOG4105CDA abc transporter atp-binding protein DN409_04440 ENOG410839P DN409_04450 ENOG4108UH6 UPF0754 membrane protein DN409_04455 ENOG4105WZB UPF0342 protein DN409_04475 ENOG4107FQX Alpha-acetolactate decarboxylase DN409_04480 ENOG4106WTF Glycosyl transferase, family 2 DN409_04485 ENOG4107R51 Glycosyl transferase, family 2 DN409_04490 ENOG4108VX5 3-methyladenine DNA glycosylase DN409_04505 ENOG4105D4P Coproporphyrinogen iii oxidase DN409_04510 ENOG4105CEY Amp-dependent synthetase and ligase DN409_04515 ENOG4107ZTW SNARE associated Golgi DN409_04535 ENOG4105CHH sulfate transporter DN409_04570 ENOG4106AKK s-layer domain-containing protein DN409_04580 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DN409_04595 ENOG4105CGU Enoyl-CoA hydratase DN409_04610 ENOG4105DER m42 family DN409_04645 ENOG4105D5U fad dependent oxidoreductase DN409_04685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN409_04690 ENOG4105C3U ABC transporter DN409_04695 ENOG4108JQ7 (ABC) transporter DN409_04715 ENOG4105CSH Transporter DN409_04725 ENOG4108MRH transcriptional regulatory protein DN409_04760 ENOG4107SCJ type I restriction enzyme EcoKI subunit R DN409_04810 ENOG4105CDU Replicative dna helicase DN409_04830 ENOG41087YS Phage shock protein A DN409_04840 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN409_04880 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN409_04940 ENOG41067XF inhibitor DN409_04945 ENOG4105F27 Major Facilitator DN409_04950 ENOG4105WAB arsR family transcriptional regulator DN409_04975 ENOG4105CMT Dihydroxyacetone kinase DN409_04995 ENOG4105CMT Dihydroxyacetone kinase DN409_05005 ENOG410847I Transcriptional regulator, BadM Rrf2 family DN409_05030 ENOG4105FBW Monooxygenase DN409_05045 ENOG4107RBI VanW family DN409_05075 ENOG4105CVK Glutamate decarboxylase DN409_05140 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) DN409_05165 ENOG4105DJ2 Major Facilitator Superfamily DN409_05180 ENOG4105ENE Histidine kinase DN409_05185 ENOG4108VB1 regulatoR DN409_05215 ENOG4107VRP DNA repair exonuclease DN409_05220 ENOG4106D4I domain protein DN409_05250 ENOG4108MUZ hydrolase DN409_05265 ENOG41067QW Transcriptional regulator DN409_05270 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DN409_05280 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DN409_05285 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DN409_05290 ENOG4105EMN RNA polymerase sigma factor DN409_05305 ENOG4105EEM helicase DN409_05310 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN409_05335 ENOG4105K59 histidine triad (HIT) protein DN409_05355 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DN409_05365 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) DN409_05415 ENOG410905X membrane-flanked domain protein DN409_05420 ENOG4105CKV Membrane DN409_05460 ENOG410905X membrane-flanked domain protein DN409_05465 ENOG4105CKV Membrane DN409_05470 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DN409_05475 ENOG4105BZ4 penicillin-binding protein DN409_05480 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DN409_05490 ENOG4105C1Q protoporphyrinogen oxidase DN409_05515 ENOG4105ECB domain protein DN409_05555 ENOG4106AXD DN409_05560 ENOG4108RQ5 Beta-lactamase domain-containing protein DN409_05565 ENOG4105DF9 Lipoate-protein, ligase DN409_05575 ENOG4105CEY Amp-dependent synthetase and ligase DN409_05590 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DN409_05595 ENOG4108I5D sulfate abc transporter DN409_05600 ENOG4105ECW sulfate abc transporter DN409_05645 ENOG4107RN3 metallophosphoesterase DN409_05650 ENOG4107TVP HD domain protein DN409_05665 ENOG4108AEY RNA polymerase sigma factor DN409_05675 ENOG41086D8 Transcriptional regulator DN409_05685 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN409_05705 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DN409_05735 ENOG4105ZU5 s-layer protein DN409_05740 ENOG4107QP3 malate synthase g DN409_05775 ENOG4105XVF Competence transcription factor DN409_05795 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination DN409_05800 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DN409_05850 ENOG4105ERH Fumarylacetoacetate hydrolase DN409_05875 ENOG4105CAQ asparagine synthetase DN409_05885 ENOG4105CH6 catalase DN409_05890 ENOG4105BZU Histidine kinase DN409_05900 ENOG4108VPT UPF0234 protein DN409_05905 ENOG4105QNR S1 RNA binding domain protein DN409_05920 ENOG4108VJ1 Transcriptional regulator (CarD family DN409_05955 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN409_05965 ENOG4107AYK membrAne DN409_05980 ENOG4108KP7 hydrolase DN409_06015 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DN409_06020 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DN409_06045 ENOG4105C31 Tryptophanyl-tRNA synthetase DN409_06065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DN409_06070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN409_06080 ENOG4108JQ7 (ABC) transporter DN409_06085 ENOG4105UQX Mate efflux family protein DN409_06110 ENOG4108ZCF integral membrane protein DN409_06120 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DN409_06130 ENOG4105DPN Oligoendopeptidase f DN409_06140 ENOG4108Z18 K06886 hemoglobin DN409_06145 ENOG4105MIX Adenylate cyclase DN409_06160 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DN409_06165 ENOG4105EMS pseudouridine synthase DN409_06185 ENOG4105K64 Glycosyl transferase, family 2 DN409_06205 ENOG4107TVC Glycosyl transferase, family 2 DN409_06225 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DN409_06230 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DN409_06240 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DN409_06325 ENOG4105CK7 Sodium proline symporter DN409_06340 ENOG4105CRQ synthase (Component I) DN409_06345 ENOG4105DDQ anthranilate synthase DN409_06350 ENOG4108I0Q anthranilate phosphoribosyltransferase DN409_06360 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase DN409_06365 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DN409_06370 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) DN409_06435 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DN409_06455 ENOG4105C7S Dehydrogenase DN409_06460 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DN409_06465 ENOG4105VZ8 Transcriptional regulator DN409_06530 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DN409_06550 ENOG4105DZ1 carboxypeptidase DN409_06555 ENOG4105VFR signal peptidase DN409_06595 ENOG4105C26 Dehydrogenase DN409_06605 ENOG4105F38 ABC transporter, permease DN409_06610 ENOG4105D38 putrescine abc transporter DN409_06615 ENOG4107RUE extracellular solute-binding protein family 1 DN409_06625 ENOG4105EYF MMPL domain protein DN409_06635 ENOG4108YBP pseudouridine synthase DN409_06645 ENOG4105K4I Scp-like extracellular DN409_06650 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DN409_06655 ENOG4105CQB FAD linked oxidase domain protein DN409_06670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_06675 ENOG4105BZU Histidine kinase DN409_06680 ENOG4105JXH GntR family transcriptional regulator DN409_06690 ENOG4107QR9 Iron-sulfur cluster binding protein DN409_06700 ENOG4106A3R peptidase DN409_06710 ENOG4108QTI )-transporter DN409_06715 ENOG4107TS3 membrane protein, TerC DN409_06720 ENOG4105CZN Potassium uptake protein DN409_06725 ENOG410681C small acid-soluble spore protein DN409_06730 ENOG4108Z7G MaoC domain protein dehydratase DN409_06750 ENOG4105CHR reductase DN409_06780 ENOG4105C4Y ABC transporter DN409_06785 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN409_06790 ENOG4107RCV ABC transporter, permease DN409_06795 ENOG4108KAZ Involved in phosphonate degradation (By similarity) DN409_06800 ENOG4107QMX Aminotransferase DN409_06810 ENOG4105E98 transcriptional regulator DeoR family DN409_06820 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DN409_06830 ENOG4105PXI polysaccharide deacetylase DN409_06840 ENOG4105BZU Histidine kinase DN409_06845 ENOG41090MY MarR family Transcriptional regulator DN409_06855 ENOG4106DF1 DN409_06860 ENOG4105BZU Histidine kinase DN409_06865 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DN409_06870 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DN409_06875 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DN409_06880 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) DN409_06895 ENOG4108R6G acetyltransferase DN409_06915 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DN409_06930 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DN409_06935 ENOG4105CUB amino acid DN409_06940 ENOG4105D82 Glutamate dehydrogenase DN409_06955 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DN409_06960 ENOG4105C26 Dehydrogenase DN409_06965 ENOG4105C8Y Acetylornithine aminotransferase DN409_06970 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DN409_06975 ENOG4105CZV ABC transporter DN409_06985 ENOG4105CJ1 ABC, transporter DN409_07025 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DN409_07030 ENOG4105EA8 2-Nitropropane dioxygenase DN409_07035 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DN409_07040 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) DN409_07045 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DN409_07065 ENOG4105NQC Flavodoxin DN409_07090 ENOG4107QMU Mate efflux family protein DN409_07095 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DN409_07125 ENOG4105CZN Potassium uptake protein DN409_07135 ENOG4105KBJ sporulation protein ytfj DN409_07155 ENOG4105CM2 brancheD-chain amino acid aminotransferase DN409_07160 ENOG4105C7K acetolactate synthase DN409_07165 ENOG4108ZP8 Acetolactate synthase small subunit DN409_07170 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DN409_07175 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DN409_07185 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DN409_07195 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) DN409_07200 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DN409_07210 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DN409_07215 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DN409_07220 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DN409_07225 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DN409_07235 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase DN409_07240 ENOG4107RVV histidinol phosphate phosphatase, hisj family DN409_07255 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN409_07260 ENOG4105E0M Sulfatase DN409_07270 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DN409_07280 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DN409_07285 ENOG4107RIQ Sulfate adenylate transferase DN409_07290 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DN409_07295 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DN409_07305 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DN409_07310 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DN409_07315 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DN409_07320 ENOG4105C8J )-transporter DN409_07340 ENOG4105DFD Na H antiporter DN409_07365 ENOG4105ENE Histidine kinase DN409_07370 ENOG4105WH1 Two component transcriptional regulator luxr family DN409_07390 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DN409_07440 ENOG4105CJ3 phosphate transporter DN409_07445 ENOG4107GRR phosphate transport regulator DN409_07450 ENOG4105BZ4 penicillin-binding protein DN409_07465 ENOG4105BZU Histidine kinase DN409_07470 ENOG4105I3N Conserved Protein DN409_07485 ENOG4105BZU Histidine kinase DN409_07515 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN409_07520 ENOG4105DZ1 carboxypeptidase DN409_07525 ENOG4108JIC nucleoside recognition domain protein DN409_07535 ENOG4105FE9 pseudouridine synthase DN409_07545 ENOG4107TWT Cytochrome c biogenesis protein DN409_07550 ENOG4105CRE cytochrome C DN409_07555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_07560 ENOG4105BZU Histidine kinase DN409_07565 ENOG4108WBT adenosyltransferase DN409_07570 ENOG41063SB peptidase DN409_07580 ENOG4108SAX Membrane DN409_07595 ENOG4105T7X DN409_07600 ENOG4105C9U ATP-dependent DNA helicase RecQ DN409_07605 ENOG4105I7S Abortive infection protein DN409_07615 ENOG4107RGJ metallophosphoesterase DN409_07620 ENOG4107X2D transcriptional regulator, merr family DN409_07625 ENOG4108S6Z Negative regulator of genetic competence DN409_07650 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DN409_07655 ENOG4107RB3 L-asparaginase DN409_07660 ENOG4105CAT Cytidine monophosphate kinase DN409_07670 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DN409_07690 ENOG4105S2F DN409_07695 ENOG41065D1 DN409_07700 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DN409_07705 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DN409_07725 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DN409_07740 ENOG4105XXQ heptaprenyl diphosphate synthase component I DN409_07745 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DN409_07750 ENOG4105EAH synthase DN409_07755 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DN409_07760 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DN409_07765 ENOG4105D49 3-dehydroquinate synthase DN409_07775 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DN409_07780 ENOG41068YB TPR repeat-containing protein DN409_07795 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DN409_07800 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DN409_07805 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit DN409_07840 ENOG4108JYZ YitT family DN409_07845 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DN409_07850 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DN409_07855 ENOG4108Z5K methylglyoxal synthase DN409_07860 ENOG4105FJR Lmbe family DN409_07865 ENOG4105CPK Glycosyl transferase (Group 1 DN409_07870 ENOG4105DJ0 Poly(A) Polymerase DN409_07880 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DN409_07885 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) DN409_07895 ENOG4105DVT helicase DN409_07900 ENOG4105YAC DN409_07920 ENOG4105CSM endonuclease III DN409_07930 ENOG4105BZ4 penicillin-binding protein DN409_07970 ENOG4108UKS UPF0398 protein DN409_07975 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) DN409_07985 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DN409_07995 ENOG4105DVT helicase DN409_08000 ENOG4105CTD carboxy-peptidase DN409_08010 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DN409_08015 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DN409_08020 ENOG4105C2W permease DN409_08025 ENOG4105DHF Membrane DN409_08030 ENOG410890F Dynamin family DN409_08040 ENOG4108W0I acetyltransferase DN409_08050 ENOG4105KHC sulfurtransferase DN409_08105 ENOG4108SZE gCN5-related N-acetyltransferase DN409_08125 ENOG41081VK Ribonuclease DN409_08190 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN409_08200 ENOG4107RWR Sodium hydrogen exchanger DN409_08205 ENOG4108Z5V transcriptional regulator, merr family DN409_08215 ENOG4105H67 Protein of unknown function (DUF421) DN409_08220 ENOG41080C8 DUF218 domain DN409_08280 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DN409_08290 ENOG4107R0U MotA TolQ exbB proton channel DN409_08295 ENOG4105ER2 Ompa motb domain protein DN409_08300 ENOG4107YTP response regulator receiver protein DN409_08305 ENOG4105CBS Chea signal transduction histidine kinase DN409_08310 ENOG4105DD5 Flagellar motor switch protein DN409_08325 ENOG4105BZU Histidine kinase DN409_08345 ENOG4105E1Q flagellar hook-associated protein DN409_08350 ENOG4105DTJ flagellar hook-associated protein DN409_08375 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DN409_08380 ENOG4108ZC9 flagellar basal-body rod protein flgc DN409_08385 ENOG41075Z6 flagellar hook-basal body complex protein fliE DN409_08390 ENOG4107U2N Flagellar M-ring protein DN409_08395 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DN409_08425 ENOG4105BZE flagellar hook protein, FlgE DN409_08440 ENOG4107R88 Chemotaxis protein (CheV) DN409_08455 ENOG4105BZU Histidine kinase DN409_08460 ENOG4107TS3 membrane protein, TerC DN409_08470 ENOG4108JB9 formate dehydrogenase DN409_08480 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DN409_08485 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DN409_08495 ENOG4105TMB Formate nitrite transporter DN409_08500 ENOG4105D06 uba thif-type nad fad binding protein DN409_08505 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN409_08510 ENOG4108ZAF Molybdopterin DN409_08515 ENOG41067WU Molybdopterin converting factor (Subunit 1) DN409_08520 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DN409_08525 ENOG4105D1F ATP-binding protein DN409_08530 ENOG4105I03 Flagellin DN409_08535 ENOG4105I03 Flagellin DN409_08540 ENOG4105E4C Lytic transglycosylase catalytic DN409_08550 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DN409_08555 ENOG4105DD5 Flagellar motor switch protein DN409_08565 ENOG4105CN7 Flagellar biosynthetic protein FliP DN409_08570 ENOG4105VS8 Flagellar biosynthetic protein fliq DN409_08580 ENOG4105D00 flagellar biosynthetic protein flhB DN409_08585 ENOG4105D7B Flagellar biosynthesis protein flha DN409_08590 ENOG4105FZW flagellar biosynthesis regulator FlhF DN409_08595 ENOG4105KTQ flagellar basal-body rod protein DN409_08600 ENOG4105CPU Monooxygenase DN409_08630 ENOG4105KAC Antibiotic biosynthesis monooxygenase DN409_08655 ENOG4105DUM transcriptional regulator, lysR family DN409_08660 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN409_08670 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component DN409_08720 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DN409_08740 ENOG4105CAQ asparagine synthetase DN409_08760 ENOG4105PGM cation diffusion facilitator family transporter DN409_08770 ENOG4105DRR Transcriptional regulator, GntR family DN409_08775 ENOG4108UZ3 Transporter DN409_08785 ENOG4105DFD Na H antiporter DN409_08790 ENOG4105C9Q fumarate hydratase class II DN409_08825 ENOG4107QJQ Mate efflux family protein DN409_08830 ENOG4105EC3 peptidase S51, dipeptidase E DN409_08850 ENOG4107QIV Cytochrome c biogenesis protein DN409_08855 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN409_08870 ENOG4105BZC d-serine deaminase DN409_08875 ENOG4106BRA Membrane DN409_08915 ENOG4105CJ1 ABC, transporter DN409_08940 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DN409_08950 ENOG4108IJ0 Aspartate ammonia-lyase DN409_08955 ENOG4105C6K Malic enzyme DN409_08995 ENOG4105CU9 asparagine synthetase A DN409_09000 ENOG41067QW Transcriptional regulator DN409_09030 ENOG4105FVX DN409_09070 ENOG4105CSR polyphosphate kinase 2 DN409_09080 ENOG4105DXI Major Facilitator superfamily DN409_09100 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DN409_09105 ENOG4105EU0 Major facilitator Superfamily DN409_09110 ENOG4105C6T cysteine synthase DN409_09130 ENOG4105C8J )-transporter DN409_09140 ENOG4105X5K response regulator receiver protein DN409_09145 ENOG4105H67 Protein of unknown function (DUF421) DN409_09165 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DN409_09170 ENOG4105E3B Multicopper oxidase DN409_09180 ENOG4105BZU Histidine kinase DN409_09185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_09190 ENOG4105CHR reductase DN409_09195 ENOG4105C01 Dihydroxy-acid dehydratase DN409_09200 ENOG4105C7B Threonine dehydratase DN409_09225 ENOG4105C6X Major Facilitator DN409_09230 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DN409_09320 ENOG41068WN DN409_09340 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DN409_09345 ENOG4105C72 UPF0176 protein DN409_09355 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DN409_09360 ENOG4105C0X amino acid DN409_09395 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) DN409_09400 ENOG4105KNA -acetyltransferase DN409_09410 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid DN409_09415 ENOG4107RHR regulatoR DN409_09425 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DN409_09430 ENOG4105D9N nucleoside DN409_09435 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DN409_09470 ENOG410811B TRANSCRIPTIONal DN409_09485 ENOG4107RAQ aminopeptidase DN409_09490 ENOG4107R16 Multicopper oxidase DN409_09515 ENOG4105C5Q Transcriptional regulator DN409_09545 ENOG4107TUM Amidinotransferase DN409_09555 ENOG4105FQP Beta-lactamase DN409_09585 ENOG4105IBP Cyclic peptide transporter DN409_09600 ENOG4108T5E Copper resistance protein DN409_09605 ENOG4105KTB nuclear export factor GLE1 DN409_09615 ENOG4107RT3 EamA-like transporter family DN409_09620 ENOG4105GZI Transcriptional regulator DN409_09625 ENOG4108Z40 Transcriptional regulator DN409_09630 ENOG4107ZXU DSBA oxidoreductase DN409_09635 ENOG4108TVJ Nitroreductase DN409_09645 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DN409_09650 ENOG4106F5Q Membrane DN409_09660 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN409_09670 ENOG4105CKI cobalamin synthesis protein DN409_09680 ENOG4105C0Z ABC transporter DN409_09685 ENOG4108IV0 ABC, transporter DN409_09690 ENOG4105C32 Amino acid ABC transporter (Permease) DN409_09700 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family DN409_09710 ENOG4105MDS 4-oxalocrotonate tautomerase DN409_09735 ENOG4105C4M (Ubiquinol oxidase) subunit I DN409_09740 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DN409_09745 ENOG4108JJ9 ABC, transporter DN409_09750 ENOG4108JJ8 (ABC) transporter DN409_09805 ENOG4105BZ1 (ABC) transporter DN409_09810 ENOG4105EFI regulatoR DN409_09815 ENOG4105BZU Histidine kinase DN409_09825 ENOG4108VQJ O-methyltransferase DN409_09830 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DN409_09835 ENOG4108ZJ4 polysaccharide deacetylase DN409_09840 ENOG4106AKJ DN409_09855 ENOG4105D6E homoserine dehydrogenase DN409_09865 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DN409_09880 ENOG4108KGH TRANSCRIPTIONal DN409_09890 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN409_09895 ENOG4105BZU Histidine kinase DN409_09900 ENOG4107VMI polysaccharide deacetylase DN409_09915 ENOG4105D7V transposase DN409_09920 ENOG4105KT7 mgtC SapB transporter DN409_09925 ENOG4105VRR gCN5-related N-acetyltransferase DN409_09935 ENOG4105DUU IucA IucC family protein DN409_09940 ENOG4105CEY Amp-dependent synthetase and ligase DN409_09955 ENOG4108WBH protein TIM barrel DN409_09960 ENOG4105YWU small acid-soluble spore protein DN409_09970 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DN409_09975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN409_10025 ENOG4105KRN Transcriptional regulator, abrb family DN409_10050 ENOG4108KB1 transcriptional regulator, arac family DN409_10055 ENOG4108JP0 extracellular solute-binding protein family 1 DN409_10060 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DN409_10065 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DN409_10070 ENOG4105CT8 Phosphorylase DN409_10075 ENOG4105DKQ ROK family DN409_10080 ENOG4105E70 isomerase DN409_10085 ENOG4105CE4 GlcNAc 6-P deacetylase DN409_10090 ENOG4105DE4 1-phosphofructokinase DN409_10095 ENOG4105D2M Aldolase DN409_10100 ENOG4105ESP cell wall surface anchor family protein DN409_10110 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase DN409_10115 ENOG4105YVS arsR family transcriptional regulator DN409_10120 ENOG4107SET aldo keto reductase DN409_10125 ENOG4107XZQ multidrug resistance protein DN409_10170 ENOG4108K88 Membrane DN409_10175 ENOG4108WPJ Ferritin-like domain DN409_10190 ENOG4105DEN Luciferase family DN409_10205 ENOG4105VMI -acetyltransferase DN409_10210 ENOG4107QM2 Aldo Keto reductase DN409_10215 ENOG4105CKI cobalamin synthesis protein DN409_10225 ENOG4105DSE periplasmic solute binding protein DN409_10240 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DN409_10245 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DN409_10270 ENOG4107TB6 phosphoglycerate mutase DN409_10290 ENOG4107T5V SNARE associated Golgi DN409_10305 ENOG4108PJD permease DN409_10315 ENOG4108S4H thioesterase Superfamily protein DN409_10345 ENOG4105SXS Protein of unknown function (DUF456) DN409_10350 ENOG4105C37 (CBS) domain DN409_10380 ENOG4108Z7R Chaperone CsaA DN409_10400 ENOG4108ZRV stage ii sporulation protein p DN409_10415 ENOG4108VXD carboxy-peptidase DN409_10420 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DN409_10445 ENOG4108ZRV stage ii sporulation protein p DN409_10455 ENOG4108X4Q Hydrolase DN409_10460 ENOG41082F9 transcriptional regulator DN409_10465 ENOG4105D94 Major Facilitator Superfamily DN409_10475 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DN409_10480 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN409_10495 ENOG41087PP glycosyltransferase MGT family DN409_10500 ENOG4108JYZ YitT family DN409_10505 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN409_10530 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DN409_10550 ENOG4105KBJ sporulation protein ytfj DN409_10575 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DN409_10605 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DN409_10610 ENOG4105EMN RNA polymerase sigma factor DN409_10635 ENOG4105CNW domain protein DN409_10645 ENOG4108V06 Glutathione peroxidase DN409_10660 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN409_10670 ENOG4108IUE nitrate reductase beta subunit DN409_10675 ENOG4105R3A Nitrate reductase DN409_10685 ENOG4107V6Q Cyclic nucleotide-binding domain DN409_10690 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DN409_10695 ENOG4105D06 uba thif-type nad fad binding protein DN409_10700 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN409_10705 ENOG4108ZAF Molybdopterin DN409_10725 ENOG4105GAK amidohydrolase 2 DN409_10735 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DN409_10740 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DN409_10745 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DN409_10750 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DN409_10755 ENOG4108IFG nitrite reductase, (NAD(P)H) DN409_10760 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) DN409_10785 ENOG4105MCT stage V sporulation protein S DN409_10800 ENOG4105C5H ABC transporter DN409_10815 ENOG4108UUM single-stranded DNA-binding protein DN409_10845 ENOG4107YX5 Pfam:DUF548 DN409_10850 ENOG4105C75 arginyL-tRNA synthetase DN409_10875 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DN409_10905 ENOG4105C5S asparaginyl-tRNA synthetase DN409_10925 ENOG4105EC2 ftsk spoIIIe DN409_10950 ENOG4106BHF DN409_10955 ENOG4106ANW SMI1_KNR4 DN409_10970 ENOG4105C8J )-transporter DN409_10990 ENOG4107XGZ Hydrolase DN409_11000 ENOG4105CY2 Citrate transporter DN409_11020 ENOG4105KD7 acetyltransferase DN409_11025 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DN409_11045 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DN409_11075 ENOG4105D7V transposase DN409_11100 ENOG4107RVG penicillin-binding protein DN409_11110 ENOG4105E9Q Acyl-transferase DN409_11115 ENOG4108UT2 hemolysin iii DN409_11120 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DN409_11125 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DN409_11135 ENOG4108RCR degv family DN409_11140 ENOG4105E8R UPF0173 metal-dependent hydrolase DN409_11145 ENOG4108KF3 Electron transport protein SCO1 SenC DN409_11150 ENOG4107Y70 Heat shock protein DN409_11155 ENOG4105CAQ asparagine synthetase DN409_11170 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DN409_11175 ENOG4108MES Periplasmic binding protein DN409_11180 ENOG4105F0I Aminotransferase DN409_11205 ENOG4108IBT Inherit from COG: transposase DN409_11225 ENOG4105E5W Transporter DN409_11260 ENOG4105D8X mechanosensitive ion channel DN409_11265 ENOG4105BZU Histidine kinase DN409_11270 ENOG4105WH1 Two component transcriptional regulator luxr family DN409_11275 ENOG4106KNT transcriptional regulator DN409_11295 ENOG4105CMG Carbohydrate kinase DN409_11300 ENOG4105C6Z Gluconate DN409_11325 ENOG4108IJ8 ABC transporter DN409_11330 ENOG4105E90 ABC transporter DN409_11365 ENOG4105C37 (CBS) domain DN409_11390 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN409_11405 ENOG4107S4Y M20 DapE family protein YgeY DN409_11410 ENOG4108TSC N-acetyltransferase DN409_11415 ENOG4108JUB Transcriptional regulator DN409_11420 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DN409_11465 ENOG410841Q phosphoesterase PA-phosphatase related protein DN409_11475 ENOG4105SZ6 Thioredoxin DN409_11555 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN409_11580 ENOG4105CHR reductase DN409_11600 ENOG4105BZ4 penicillin-binding protein DN409_11610 ENOG4105CZM Major Facilitator DN409_11625 ENOG4105DXD 2-methylcitrate dehydratase DN409_11630 ENOG4105CR4 methylisocitrate lyase DN409_11635 ENOG4105C1G acyl-Coa dehydrogenase DN409_11640 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DN409_11650 ENOG4105N14 lysine exporter protein LysE YggA DN409_11655 ENOG4105E39 Enoyl-CoA hydratase DN409_11670 ENOG4107RFY SbcCD D subunit DN409_11690 ENOG4105FCD Major Facilitator DN409_11695 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DN409_11700 ENOG4105E4F Isochorismate synthase DN409_11705 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DN409_11710 ENOG4105WQI isochorismatase DN409_11715 ENOG4105CEY Amp-dependent synthetase and ligase DN409_11720 ENOG4105WQT MbtH domain protein DN409_11725 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN409_11740 ENOG4105K70 DNA-binding protein DN409_11755 ENOG4105BZG amino acid carrier protein DN409_11785 ENOG4105FE9 pseudouridine synthase DN409_11790 ENOG4105C22 threonyL-tRNA synthetase DN409_11795 ENOG4105VMP Transcriptional regulator DN409_11805 ENOG4105C19 ABC transporter DN409_11860 ENOG4105C37 (CBS) domain DN409_11865 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DN409_11885 ENOG41081I9 integral membrane protein DN409_11895 ENOG4108Y4K DNA-binding transcriptional activator DN409_11915 ENOG4107MII Sugar-specific transcriptional regulator TrmB DN409_11935 ENOG41067SE Tetr family transcriptional regulator DN409_11940 ENOG4105EYF MMPL domain protein DN409_11965 ENOG4105WCN acetyltransferase DN409_12010 ENOG4105C1Q protoporphyrinogen oxidase DN409_12020 ENOG41068WN DN409_12050 ENOG4107V2S Transcriptional regulator DN409_12055 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DN409_12115 ENOG4105DND Transcriptional regulator DN409_12120 ENOG4108JPW Aminotransferase DN409_12125 ENOG4108RPX mosc domain containing protein DN409_12140 ENOG4105BZ1 (ABC) transporter DN409_12145 ENOG4105BZ1 (ABC) transporter DN409_12160 ENOG4108VP3 Lysine exporter protein (LysE YggA) DN409_12165 ENOG4108JCI Transcriptional regulator DN409_12305 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DN409_12315 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B DN409_12320 ENOG4108KPJ rna polymerase sigma factor DN409_12340 ENOG4105F32 YngK protein DN409_12360 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DN409_12365 ENOG4105RD7 BadF BadG BcrA BcrD DN409_12375 ENOG4107STF Involved in phosphonate degradation (By similarity) DN409_12425 ENOG4105C1J atp-dependent rna helicase DN409_12430 ENOG41088CC tellurite resistance protein tehB DN409_12440 ENOG4108V4B ThiJ pfpI DN409_12450 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DN409_12485 ENOG4105CIN aminoacyl-histidine dipeptidase DN409_12490 ENOG4105EQK -acetyltransferase DN409_12505 ENOG4105C19 ABC transporter DN409_12540 ENOG4105C19 ABC transporter DN409_12545 ENOG4107RBB ABC transporter, permease DN409_12560 ENOG4105BZU Histidine kinase DN409_12600 ENOG4107RVG penicillin-binding protein DN409_12630 ENOG4105EMN RNA polymerase sigma factor DN409_12640 ENOG4107RF6 penicillin-binding protein DN409_12645 ENOG4107RF6 penicillin-binding protein DN409_12680 ENOG4105CEP NADH dehydrogenase DN409_12685 ENOG4107TPS domain protein DN409_12700 ENOG4105E1K spore germination protein DN409_12730 ENOG4108M1A Chitin-binding protein DN409_12735 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C DN409_12745 ENOG4107RGJ metallophosphoesterase DN409_12755 ENOG4105CJ1 ABC, transporter DN409_12765 ENOG4107Z3H Transcriptional regulator, TetR family DN409_12775 ENOG4105C1G acyl-Coa dehydrogenase DN409_12780 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DN409_12785 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DN409_12790 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DN409_12795 ENOG4105E39 Enoyl-CoA hydratase DN409_12800 ENOG4107QX3 carboxylase DN409_12805 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DN409_12845 ENOG4105DBI uridine monophosphokinase DN409_12880 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DN409_12905 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DN409_12920 ENOG4105ED2 Beta-lactamase DN409_12930 ENOG4105CHR reductase DN409_12935 ENOG4105KVH Transcriptional regulator DN409_12960 ENOG4105J7D transcriptional regulator DN409_12975 ENOG4105CUV Homoserine Kinase DN409_12990 ENOG4105SX7 Transporter DN409_13005 ENOG4105CHR reductase DN409_13020 ENOG4105CPQ Dehydrogenase DN409_13030 ENOG410900G Protein of unknown function (DUF421) DN409_13045 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN409_13050 ENOG4105FDR Membrane DN409_13055 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) DN409_13070 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DN409_13080 ENOG4105CGH 5'-nucleotidase DN409_13090 ENOG4108IUM Glycogen debranching enzyme DN409_13120 ENOG4107WD8 ABC transporter, permease DN409_13155 ENOG4105BZU Histidine kinase DN409_13160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_13165 ENOG4105U0R haloacid dehalogenase-like hydrolase DN409_13190 ENOG4107VFR oxidoreductase DN409_13195 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN409_13210 ENOG4105BZ1 (ABC) transporter DN409_13220 ENOG4107RA9 decarboxylase DN409_13240 ENOG4105PKS Excinuclease abc c subunit domain protein DN409_13275 ENOG4105KWG Pfam:DUF1696 DN409_13280 ENOG4108NRW Phospholipase, patatin family DN409_13305 ENOG4108XI2 Domain of unknown function (DUF1963) DN409_13330 ENOG4108Z4K mutator MutT protein DN409_13335 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DN409_13340 ENOG4105E09 nadh pyrophosphatase DN409_13350 ENOG4105FCD Major Facilitator DN409_13385 ENOG4107Y9U Membrane DN409_13400 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DN409_13415 ENOG4105KVH Transcriptional regulator DN409_13425 ENOG4107Y80 Major Facilitator superfamily DN409_13445 ENOG4105BZ1 (ABC) transporter DN409_13475 ENOG4105CJN penicillin-binding protein DN409_13480 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DN409_13485 ENOG4105CB2 alcohol dehydrogenase DN409_13490 ENOG4105GR3 Histidine kinase DN409_13495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_13515 ENOG4108HGU Histidine kinase DN409_13530 ENOG4108JJB ABC transporter DN409_13535 ENOG4108V7D UPF0397 protein DN409_13555 ENOG4107RF6 penicillin-binding protein DN409_13560 ENOG4105BZU Histidine kinase DN409_13565 ENOG410667J hydrolase DN409_13670 ENOG4105ETU transcriptional activator (TenA DN409_13685 ENOG4105D6E homoserine dehydrogenase DN409_13720 ENOG4105E5W Transporter DN409_13750 ENOG4105CPC Aldo Keto reductase DN409_13755 ENOG4106NZI LysR family Transcriptional regulator DN409_13800 ENOG4105CIS alcohol dehydrogenase DN409_13845 ENOG4105MSI germination protein ypeb DN409_13870 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) DN409_13875 ENOG4106IPI cyclase, family DN409_13880 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DN409_13885 ENOG4107Z3H Transcriptional regulator, TetR family DN409_13900 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DN409_13915 ENOG4105E98 transcriptional regulator DeoR family DN409_13940 ENOG4107QKR Dehydrogenase DN409_13950 ENOG4107RUY (E1 component), alpha subunit DN409_13970 ENOG4105E1F short-chain dehydrogenase reductase DN409_13975 ENOG4105RHY Pfam:UPF0157 DN409_14010 ENOG4107SQ8 Glycine betaine DN409_14015 ENOG4108IJ7 Glycine betaine DN409_14040 ENOG4105E66 phosphoriboisomerase A DN409_14045 ENOG41082BV acetyltransferase DN409_14050 ENOG4108M1A Chitin-binding protein DN409_14060 ENOG41087PP glycosyltransferase MGT family DN409_14080 ENOG4105MSB protein, conserved in bacteria DN409_14105 ENOG4108Z7F N-acetyltransferase DN409_14135 ENOG4105EEM helicase DN409_14155 ENOG4105C9U ATP-dependent DNA helicase RecQ DN409_14190 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase DN409_14195 ENOG4108M1A Chitin-binding protein DN409_14225 ENOG4105BZG amino acid carrier protein DN409_14230 ENOG4105C26 Dehydrogenase DN409_14235 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DN409_14240 ENOG4105CTU Proline racemase DN409_14245 ENOG4105CTU Proline racemase DN409_14250 ENOG41080HI glycine oxidase DN409_14260 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein DN409_14290 ENOG4107T5V SNARE associated Golgi DN409_14305 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DN409_14320 ENOG4105DTQ mandelate racemase muconate lactonizing DN409_14340 ENOG4105CPC Aldo Keto reductase DN409_14380 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) DN409_14390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_14405 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 DN409_14410 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DN409_14415 ENOG4105DPN Oligoendopeptidase f DN409_14430 ENOG4105EPR degv family DN409_14460 ENOG4105CHJ isochorismatase hydrolase DN409_14495 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DN409_14500 ENOG4106K7D Major facilitator family transporter DN409_14525 ENOG4108IAJ Nad-dependent epimerase dehydratase DN409_14530 ENOG4107SBE Glycosyl transferase (Group 1 DN409_14560 ENOG4107SBE Glycosyl transferase (Group 1 DN409_14565 ENOG4108KS4 Spore coat protein DN409_14580 ENOG4107BMA Transglycosylase associated protein DN409_14595 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DN409_14630 ENOG4105CHM Aminotransferase DN409_14660 ENOG4105DVE abc transporter atp-binding protein DN409_14665 ENOG4105FDP GntR family transcriptional regulator DN409_14710 ENOG4105C02 permease DN409_14755 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DN409_14790 ENOG4107VC0 DNA alkylation repair enzyme DN409_14800 ENOG4107VMI polysaccharide deacetylase DN409_14815 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN409_14830 ENOG4105C5H ABC transporter DN409_14835 ENOG4105EYF MMPL domain protein DN409_14845 ENOG41082JN Transcriptional regulator DN409_14850 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DN409_14880 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DN409_14885 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DN409_14915 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DN409_14930 ENOG41069ER domain protein DN409_14940 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DN409_14950 ENOG4108YYH Nadph-dependent fmn reductase DN409_14980 ENOG4105DWT malate dehydrogenase (quinone) DN409_14985 ENOG4105D4B ABC, transporter DN409_14990 ENOG4105DKT Transcriptional regulator DN409_14995 ENOG4107RYS Autoinducer-2 (AI-2) kinase DN409_15005 ENOG41061GT Aldolase DN409_15010 ENOG4108I0C methyltransferase DN409_15025 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase DN409_15030 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DN409_15050 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DN409_15055 ENOG41075H3 AraC family transcriptional regulator DN409_15065 ENOG4108YV3 Protein of unknown function (DUF2711) DN409_15080 ENOG41075H3 AraC family transcriptional regulator DN409_15105 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) DN409_15110 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DN409_15115 ENOG4105II7 pyrroline-5-carboxylate reductase DN409_15120 ENOG4105ECK Fatty Acid Desaturase DN409_15135 ENOG4105VMP Transcriptional regulator DN409_15180 ENOG41068WN DN409_15215 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN409_15235 ENOG4105C8Y Acetylornithine aminotransferase DN409_15275 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN409_15285 ENOG4108TVJ Nitroreductase DN409_15290 ENOG4105FS7 Transcriptional regulator DN409_15330 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DN409_15365 ENOG4108XET gCN5-related N-acetyltransferase DN409_15380 ENOG4108PCN EamA-like transporter family DN409_15410 ENOG4105RHY Pfam:UPF0157 DN409_15435 ENOG410635A Membrane DN409_15445 ENOG4108IQI permease DN409_15455 ENOG4105F1N DNA alkylation repair DN409_15490 ENOG4107RF6 penicillin-binding protein DN409_15495 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DN409_15505 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) DN409_15520 ENOG4105E7W lamb ycsf family protein DN409_15530 ENOG4105P4J Allophanate hydrolase, subunit 1 DN409_15535 ENOG4107258 Transcriptional regulator DN409_15545 ENOG4106N3A copper homeostasis protein cutc DN409_15555 ENOG4105FDT acyl-CoA dehydrogenase DN409_15580 ENOG41082BM Transcriptional regulator, arsr family DN409_15595 ENOG4105DWD nucleoside recognition domain protein DN409_15630 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DN409_15640 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DN409_15650 ENOG4105FQP Beta-lactamase DN409_15680 ENOG4105F6J Alpha beta hydrolase fold DN409_15695 ENOG4107VMI polysaccharide deacetylase DN409_15705 ENOG4105BZU Histidine kinase DN409_15710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_15720 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DN409_15740 ENOG4105DET Rhamnulokinase DN409_15745 ENOG4107W7X Aldolase DN409_15755 ENOG4105CNN ABC, transporter DN409_15765 ENOG4105NWF RbsD or FucU transport DN409_15770 ENOG4105ETE Transcriptional regulator (LacI family DN409_15780 ENOG4105Z7P Acetyltransferase (GNAT) family DN409_15795 ENOG41067QW Transcriptional regulator DN409_15805 ENOG4107P5I polyketide synthase DN409_15810 ENOG4108IG5 Transcriptional regulator DN409_15815 ENOG4105CHR reductase DN409_15820 ENOG4108YXU transcriptional regulator AsnC family DN409_15845 ENOG4105D7V transposase DN409_15865 ENOG4105DMQ Methyltransferase DN409_15870 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DN409_15875 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN409_15905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_15910 ENOG41062D9 Histidine kinase DN409_15940 ENOG4105K6H D-cysteine desulfhydrase DN409_15965 ENOG4105E0Y RtcB Protein DN409_15980 ENOG4105JQZ Methyltransferase DN409_16000 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DN409_16005 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DN409_16025 ENOG4105BZU Histidine kinase DN409_16035 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DN409_16050 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DN409_16070 ENOG4108JQ1 Dehydrogenase DN409_16075 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DN409_16105 ENOG4105YWU small acid-soluble spore protein DN409_16145 ENOG4108IG5 Transcriptional regulator DN409_16185 ENOG4108ISG Major Facilitator DN409_16200 ENOG4107MII Sugar-specific transcriptional regulator TrmB DN409_16205 ENOG4105CZM Major Facilitator DN409_16235 ENOG4105W1Y Transcriptional regulator DN409_16270 ENOG4105VZ8 Transcriptional regulator DN409_16290 ENOG4105DYB Isoaspartyl dipeptidase DN409_16335 ENOG4105DH8 myo-inositol catabolism DN409_16340 ENOG4105D2N Aldolase DN409_16365 ENOG4105CK5 oxidoreductase DN409_16375 ENOG4105IE8 Alpha-ketoglutarate permease DN409_16380 ENOG4105ETE Transcriptional regulator (LacI family DN409_16385 ENOG4105D7V transposase DN409_16505 ENOG4105EYH Exonuclease DN409_16575 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DN409_16775 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DN409_16780 ENOG4105CRW Short chain fatty acid transporter DN409_16790 ENOG4105DYS nad(p)h dehydrogenase (quinone) DN409_16830 ENOG4108JJB ABC transporter DN409_16860 ENOG4108K8S endonuclease I DN409_16865 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DN409_16885 ENOG4108Z66 YbaK ebsC protein DN409_16905 ENOG4105G6Z alkaline phosphatase DN409_16910 ENOG4108RCM Nitroreductase DN409_16915 ENOG4105KVH Transcriptional regulator DN409_16930 ENOG4108PSK reductase DN409_16970 ENOG4108AEY RNA polymerase sigma factor DN409_17010 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DN409_17015 ENOG4105DKQ ROK family DN409_17020 ENOG4106UW1 Major Facilitator superfamily DN409_17025 ENOG4108UW5 maltose o-acetyltransferase DN409_17030 ENOG4105C31 Tryptophanyl-tRNA synthetase DN409_17045 ENOG4107BMA Transglycosylase associated protein DN409_17090 ENOG4105C37 (CBS) domain DN409_17110 ENOG4105DDN Pentapeptide repeat-containing protein DN409_17115 ENOG4105XDF Protein of unknown function (DUF1272) DN409_17120 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DN409_17125 ENOG4105CMG Carbohydrate kinase DN409_17140 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DN409_17175 ENOG4105JAB phenazine biosynthesis protein, phzf family DN409_17185 ENOG4105CHR reductase DN409_17200 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DN409_17205 ENOG4105KVH Transcriptional regulator DN409_17245 ENOG4108VXD carboxy-peptidase DN409_17320 ENOG4105EFI regulatoR DN409_17345 ENOG4105E5W Transporter DN409_17370 ENOG4108IND Tetr family transcriptional regulator DN409_17420 ENOG4105C44 Serine transporter DN409_17445 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DN409_17475 ENOG4107R6D beta-lactam binding protein AmpH DN409_17485 ENOG4105H3G oxidoreductase DN409_17530 ENOG4105K7K Transcriptional regulator DN409_17535 ENOG4105CIS alcohol dehydrogenase DN409_17565 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN409_17580 ENOG4105C3S Mate efflux family protein DN409_17585 ENOG4105C26 Dehydrogenase DN409_17590 ENOG4105MWK D-amino acid dehydrogenase, small subunit DN409_17600 ENOG4108TN2 lmbE family DN409_17610 ENOG4107R3E Citrate transporter DN409_17630 ENOG4108MES Periplasmic binding protein DN409_17635 ENOG4105EHG Permease protein DN409_17640 ENOG4105DQ5 transport system permease protein DN409_17645 ENOG4105NX3 Membrane DN409_17670 ENOG4107V2S Transcriptional regulator DN409_17690 ENOG4105C98 muts2 protein DN409_17705 ENOG4105E5K Alpha-amylase DN409_17710 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DN409_17715 ENOG4105DPN Oligoendopeptidase f DN409_17720 ENOG4105DWY Agmatine deiminase DN409_17740 ENOG4105FFC UPF0187 protein DN409_17755 ENOG4108A04 Beta-lactamase DN409_17770 ENOG4105EGI Transcriptional regulator DN409_17790 ENOG4105EEM helicase DN409_17805 ENOG41082BM Transcriptional regulator, arsr family DN409_17810 ENOG4105CIS alcohol dehydrogenase DN409_17815 ENOG4105CNG UPF0061 protein DN409_17825 ENOG410780I phosphoprotein phosphatase activity DN409_17845 ENOG4105CQB FAD linked oxidase domain protein DN409_17865 ENOG4105KT7 mgtC SapB transporter DN409_17875 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DN409_17880 ENOG4105EAB amino acid AbC transporter DN409_17890 ENOG4108HW4 amino acid AbC transporter DN409_17895 ENOG41073R8 VanW family DN409_17905 ENOG4108R1P DN409_17920 ENOG4105VEQ Cold shock protein DN409_17960 ENOG410904N short-chain dehydrogenase reductase DN409_17970 ENOG4106IQC argininosuccinate lyase DN409_17985 ENOG4108IA2 Sodium pantothenate symporter DN409_17995 ENOG4105C26 Dehydrogenase DN409_18000 ENOG4105CHR reductase DN409_18010 ENOG4105EWU Squalene--hopene cyclase DN409_18020 ENOG4105FR1 rard protein DN409_18025 ENOG410696E Membrane DN409_18030 ENOG4105CUB amino acid DN409_18080 ENOG4108KGH TRANSCRIPTIONal DN409_18090 ENOG4105EMN RNA polymerase sigma factor DN409_18100 ENOG4105CIG ABC transporter DN409_18120 ENOG4105D9R oxidoreductase DN409_18130 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DN409_18135 ENOG4105K4P CoA-binding domain protein DN409_18140 ENOG4105C0H protease DN409_18145 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_18150 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) DN409_18155 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DN409_18165 ENOG4105W8X HesB YadR YfhF-family protein DN409_18190 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DN409_18195 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN409_18230 ENOG4105BZ1 (ABC) transporter DN409_18235 ENOG4108TYN CAAX amino terminal protease family protein DN409_18240 ENOG4108I0Z Aconitate hydratase DN409_18270 ENOG4105E5W Transporter DN409_18280 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DN409_18300 ENOG4107F3J Amp-dependent synthetase and ligase DN409_18305 ENOG4107ZYJ bioY protein DN409_18310 ENOG4105CEY Amp-dependent synthetase and ligase DN409_18360 ENOG4107AYK membrAne DN409_18375 ENOG4105BZU Histidine kinase DN409_18385 ENOG4105FBA Phospholipase Carboxylesterase DN409_18390 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DN409_18395 ENOG4105CBC glutamate synthase DN409_18400 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DN409_18410 ENOG4108VJ1 Transcriptional regulator (CarD family DN409_18415 ENOG4108903 Formimidoylglutamase DN409_18425 ENOG4105CGP Urocanate hydratase DN409_18440 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) DN409_18475 ENOG4107QIV Cytochrome c biogenesis protein DN409_18490 ENOG4105CH2 amidohydrolase DN409_18495 ENOG4108TU7 Inherit from COG: (ABC) transporter DN409_18500 ENOG4105CJ1 ABC, transporter DN409_18510 ENOG4107RSM transcriptional regulator DN409_18520 ENOG41067MG lrgb family DN409_18545 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN409_18565 ENOG4105BZ1 (ABC) transporter DN409_18570 ENOG4105BZ1 (ABC) transporter DN409_18605 ENOG4108HW3 (ABC) transporter DN409_18610 ENOG4105CGH 5'-nucleotidase DN409_18620 ENOG4108SVB resolvase DN409_18625 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DN409_18640 ENOG4105K7K Transcriptional regulator DN409_18645 ENOG4105BZ1 (ABC) transporter DN409_18680 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DN409_18690 ENOG4105D3Q Sugar transferase DN409_18730 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) DN409_18740 ENOG4108KMV Glycosyl transferase (Group 1 DN409_18745 ENOG41068W6 Capsular polysaccharide biosynthesis protein DN409_18750 ENOG4108SHN Glycosyl transferase, family 2 DN409_18755 ENOG4108KMV Glycosyl transferase (Group 1 DN409_18760 ENOG4108PQP glycosyl transferase group 1 DN409_18770 ENOG4107YJ4 chain length determinant protein DN409_18775 ENOG4105HTX biosynthesis protein DN409_18780 ENOG4105C5F glutamine synthetase DN409_18785 ENOG4105KV4 Transcriptional regulator DN409_18790 ENOG4105CXI aluminum resistance protein DN409_18795 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DN409_18800 ENOG4105EN6 Membrane DN409_18805 ENOG4106F1P AAA ATPase, central domain protein DN409_18825 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DN409_18835 ENOG41069ER domain protein DN409_18840 ENOG4105DM4 PTS System DN409_18845 ENOG4105DE4 1-phosphofructokinase DN409_18850 ENOG4105E98 transcriptional regulator DeoR family DN409_18855 ENOG4107QW4 alcohol dehydrogenase DN409_18860 ENOG4108SJC Membrane DN409_18870 ENOG4105C85 amino acid DN409_18895 ENOG4105TMB Formate nitrite transporter DN409_18900 ENOG4105K70 DNA-binding protein DN409_18910 ENOG4105C59 p-type ATPase DN409_18915 ENOG410681U heavy metal transport detoxification protein DN409_18920 ENOG4105VPX protein, conserved in bacteria DN409_18940 ENOG4105NIV Esterase DN409_18945 ENOG4105E0A ABC, transporter DN409_18965 ENOG4105CGK Exodeoxyribonuclease III DN409_18975 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DN409_18980 ENOG4105D03 DNA-3-methyladenine glycosylase II DN409_18985 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DN409_19005 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DN409_19010 ENOG4105BZU Histidine kinase DN409_19050 ENOG41067MG lrgb family DN409_19065 ENOG4107TTQ Alpha beta hydrolase fold DN409_19070 ENOG4107YEI lmbE family DN409_19080 ENOG4108S3Y transcriptional regulator DN409_19085 ENOG4105CS2 ec 3.2.1.21 DN409_19095 ENOG4105F0V Cell wall hydrolase DN409_19105 ENOG410890F Dynamin family DN409_19115 ENOG4105CS2 ec 3.2.1.21 DN409_19120 ENOG4105C5Y PTS System DN409_19125 ENOG4105CID antiterminator DN409_19135 ENOG4105WAB arsR family transcriptional regulator DN409_19140 ENOG4105T38 integral membrane protein DN409_19150 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DN409_19155 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) DN409_19170 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DN409_19175 ENOG4105DQU oxidoreductase, subunit beta DN409_19180 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DN409_19185 ENOG4108IGT Dipeptidase DN409_19190 ENOG4105MCT stage V sporulation protein S DN409_19195 ENOG4105D48 metallophosphoesterase DN409_19200 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) DN409_19210 ENOG4105CEV competence damage-inducible protein DN409_19215 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DN409_19230 ENOG4105XZV Protein of unknown function (DUF3243) DN409_19235 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DN409_19255 ENOG4105UIB (ABC) transporter DN409_19260 ENOG4108JQ9 ABC transporter DN409_19265 ENOG4105DIH basic membrane DN409_19270 ENOG4105FDP GntR family transcriptional regulator DN409_19280 ENOG4107QZI cell division protein FtsK DN409_19290 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DN409_19300 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DN409_19310 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DN409_19315 ENOG4108S0H Dipicolinic acid synthetase, b subunit DN409_19320 ENOG4105E35 Dipicolinate synthase subunit A DN409_19330 ENOG4105C1V Peptidase, M16 DN409_19340 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DN409_19350 ENOG4105DTN riboflavin biosynthesis protein ribF DN409_19365 ENOG4105W7A Protein of unknown function (DUF503) DN409_19370 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DN409_19375 ENOG4105VHM ribosomal protein DN409_19380 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DN409_19385 ENOG4105CHV Transcription elongation factor NusA DN409_19390 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DN409_19395 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DN409_19400 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DN409_19405 ENOG4105DZP Membrane-associated zinc metalloprotease DN409_19415 ENOG4105KNE Phosphatidate cytidylyltransferase DN409_19420 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DN409_19425 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DN409_19435 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) DN409_19440 ENOG4105CE9 30S ribosomal protein S2 DN409_19450 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) DN409_19455 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) DN409_19460 ENOG4108HE4 integrase family DN409_19465 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) DN409_19470 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DN409_19475 ENOG4105C79 DNA protecting protein DprA DN409_19480 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DN409_19490 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DN409_19495 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DN409_19510 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DN409_19515 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DN409_19520 ENOG4105VB6 UPF0109 protein DN409_19535 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) DN409_19540 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DN409_19545 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DN409_19550 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DN409_19555 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DN409_19560 ENOG4105CHR reductase DN409_19565 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DN409_19570 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) DN409_19580 ENOG4105CB5 ATP-dependent DNA helicase recG DN409_19585 ENOG4105DP4 dak2 domain fusion protein ylov DN409_19590 ENOG4108ZAA Alkaline-shock protein DN409_19605 ENOG4105FJ0 thiamine DN409_19610 ENOG4105DJV ribulose-phosphate 3-epimerase DN409_19620 ENOG4105D9P serine threonine protein kinase DN409_19625 ENOG4108ZF3 Phosphatase DN409_19630 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DN409_19635 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DN409_19640 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DN409_19645 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DN409_19650 ENOG4105C25 Primosomal protein n' DN409_19655 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DN409_19675 ENOG4105DSJ YicC domain protein DN409_19685 ENOG4105F23 Fibronectin-binding protein DN409_19695 ENOG4105DC7 peptidase M24 DN409_19735 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) DN409_19740 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DN409_19745 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DN409_19755 ENOG4105CD3 dihydroorotase DN409_19760 ENOG4105CXT aspartate transcarbamylase DN409_19770 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) DN409_19775 ENOG4105C34 Pseudouridine synthase DN409_19790 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DN409_19800 ENOG4105DBK s4 domain protein DN409_19805 ENOG41067XK integral membrane protein DN409_19810 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) DN409_19815 ENOG4105DFA alanine racemase domain protein DN409_19820 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DN409_19825 ENOG4105WR5 sporulation protein, YlmC YmxH family DN409_19835 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN409_19845 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DN409_19850 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DN409_19855 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DN409_19865 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DN409_19870 ENOG4105CNI cell division protein FtsW DN409_19875 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DN409_19880 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DN409_19885 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DN409_19890 ENOG4105CJN penicillin-binding protein DN409_19895 ENOG4105CJN penicillin-binding protein DN409_19905 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DN409_19910 ENOG41074B2 UPF0747 protein DN409_19935 ENOG4105KNH Nucleic acid-binding protein DN409_19945 ENOG41063PX domain protein DN409_19950 ENOG4105D78 K07001 NTE family protein DN409_19955 ENOG4105H20 Sporulation integral membrane protein YlbJ DN409_19965 ENOG4106H78 methyltransferase DN409_19975 ENOG4105WUC UPF0298 protein DN409_19985 ENOG4107TB6 phosphoglycerate mutase DN409_20000 ENOG4106UY4 Inherit from COG: Scp-like extracellular DN409_20045 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DN409_20055 ENOG4105CNI cell division protein FtsW DN409_20060 ENOG4105ZPI UPF0358 protein DN409_20070 ENOG4108IAB Phoh family DN409_20090 ENOG4105QA2 DN409_20095 ENOG4105CI3 gtp-binding protein typa DN409_20105 ENOG4105ECY inositol monophosphatase DN409_20115 ENOG4108WQ8 UPF0637 protein DN409_20120 ENOG4105WBI UPF0223 protein DN409_20125 ENOG4105CXN decarboxylase DN409_20175 ENOG4105C7S Dehydrogenase DN409_20180 ENOG4105CPP Dehydrogenase, E1 component DN409_20195 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DN409_20200 ENOG4108X4Q Hydrolase DN409_20215 ENOG4105CN5 Metallo-Beta-Lactamase DN409_20220 ENOG4107ZYR domain protein DN409_20235 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) DN409_20255 ENOG4108XRC Protein of unknown function (DUF458) DN409_20265 ENOG4107IN1 Protein of unknown function (DUF1797) DN409_20280 ENOG4105EPM Diguanylate phosphodiesterase DN409_20285 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DN409_20300 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DN409_20310 ENOG4105UIN DN409_20345 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DN409_20365 ENOG4108HGU Histidine kinase DN409_20375 ENOG4105CHM Aminotransferase DN409_20380 ENOG4105FKQ transcriptional regulator DN409_20385 ENOG4105EG2 ABC transporter, permease DN409_20395 ENOG4107FKK extracellular solute-binding protein family 1 DN409_20405 ENOG4105CG3 alpha amylase, catalytic region DN409_20455 ENOG4105CHU acetyl-coa acetyltransferase DN409_20490 ENOG4105K7K Transcriptional regulator DN409_20495 ENOG4105DTD Dehydrogenase DN409_20515 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DN409_20535 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DN409_20555 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DN409_20565 ENOG4105BZU Histidine kinase DN409_20585 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DN409_20600 ENOG4105CID antiterminator DN409_20610 ENOG4105FDP GntR family transcriptional regulator DN409_20620 ENOG4105CE4 GlcNAc 6-P deacetylase DN409_20630 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DN409_20640 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DN409_20660 ENOG4107ZE5 PPIases accelerate the folding of proteins DN409_20665 ENOG4105PTM secreted protein DN409_20670 ENOG4105J7I hydrolase DN409_20680 ENOG4105G6R Stage v sporulation protein ae DN409_20690 ENOG4105CZ3 stage V sporulation protein ad DN409_20695 ENOG41090VF Stage v sporulation protein ac DN409_20715 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN409_20725 ENOG41082AN stage II sporulation protein DN409_20730 ENOG4105DZ1 carboxypeptidase DN409_20735 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DN409_20740 ENOG4105DVE abc transporter atp-binding protein DN409_20775 ENOG4105D7N magnesium and cobalt transport protein CorA DN409_20790 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DN409_20800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DN409_20810 ENOG4105I3K Ferric uptake regulator, Fur family DN409_20815 ENOG4105MZ9 stage II sporulation protein m DN409_20835 ENOG4105CPC Aldo Keto reductase DN409_20845 ENOG4105RHY Pfam:UPF0157 DN409_20865 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DN409_20875 ENOG4105ETE Transcriptional regulator (LacI family DN409_20880 ENOG4108YM7 Gcn5-related n-acetyltransferase DN409_20900 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DN409_20905 ENOG4108R6K riboflavin synthase, subunit alpha DN409_20910 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DN409_20935 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN409_20940 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN409_20945 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DN409_20955 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN409_20965 ENOG4105DFD Na H antiporter DN409_20970 ENOG4105CGH 5'-nucleotidase DN409_21005 ENOG4105CAS nag kinase DN409_21010 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DN409_21015 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DN409_21025 ENOG4108IXY short-chain dehydrogenase reductase DN409_21030 ENOG41069FQ Metallo-beta-lactamase superfamily DN409_21035 ENOG4105II7 pyrroline-5-carboxylate reductase DN409_21040 ENOG4105EJQ L-serine dehydratase DN409_21055 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DN409_21090 ENOG4108RDQ ABC transporter DN409_21105 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DN409_21120 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DN409_21125 ENOG4105D9U N-acetyltransferase DN409_21135 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DN409_21140 ENOG4108QEG Membrane DN409_21145 ENOG4105CDA abc transporter atp-binding protein DN409_21150 ENOG4105E5Q amino acid AbC transporter DN409_21155 ENOG4108HW3 (ABC) transporter DN409_21165 ENOG4105G7B Protein of unknown function (DUF2992) DN409_21170 ENOG4105E09 nadh pyrophosphatase DN409_21175 ENOG4108QY0 Membrane DN409_21185 ENOG4105C7S Dehydrogenase DN409_21190 ENOG4105CPP Dehydrogenase, E1 component DN409_21210 ENOG4107RDP Dehydrogenase DN409_21225 ENOG4108JUB Transcriptional regulator DN409_21230 ENOG4106CCJ Protein of unknown function (DUF2627) DN409_21235 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DN409_21270 ENOG4108IBT Inherit from COG: transposase DN409_21280 ENOG4107QQR Sporulation DN409_21290 ENOG4105S1Z Stage IV sporulation protein B DN409_21295 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DN409_21305 ENOG4105DX0 Hemolysin A DN409_21310 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DN409_21315 ENOG4105CTB Polyprenyl synthetase DN409_21320 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DN409_21325 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DN409_21330 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DN409_21335 ENOG4105M7K Involved in the transcription termination process (By similarity) DN409_21340 ENOG4108ZSR alkaline shock protein DN409_21345 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DN409_21370 ENOG410644B Stage III sporulation protein af DN409_21380 ENOG4105KQ4 Stage iii sporulation protein ad DN409_21385 ENOG4108CQH stage III sporulation protein AC DN409_21390 ENOG4105KR5 Stage iii sporulation protein DN409_21395 ENOG4105CD2 stage iii sporulation protein aa DN409_21415 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DN409_21420 ENOG4105DC7 peptidase M24 DN409_21425 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DN409_21435 ENOG4105CBJ Metal-dependent enzyme DN409_21445 ENOG4107YBY Hydrolase DN409_21475 ENOG41082GG biotin lipoate A B protein ligase DN409_21480 ENOG4105WZW rhodanese family DN409_21505 ENOG41080TC multidrug resistance protein DN409_21535 ENOG4105CJ1 ABC, transporter DN409_21540 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DN409_21555 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DN409_21560 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DN409_21565 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DN409_21570 ENOG4105C0D helicase DN409_21600 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DN409_21695 ENOG4105C3R Methionine synthase DN409_21705 ENOG4105C28 cystathionine DN409_21710 ENOG4105C28 cystathionine DN409_21725 ENOG4105C5X domain protein DN409_21735 ENOG4105DKQ ROK family DN409_21745 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DN409_21760 ENOG4108UTW Plays a role in the regulation of phosphate uptake DN409_21765 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DN409_21770 ENOG4105E2Z phosphate ABC transporter (Permease DN409_21775 ENOG4105C8U phosphate abc transporter DN409_21780 ENOG4105PWN phosphate abc transporter DN409_21785 ENOG4107RF6 penicillin-binding protein DN409_21795 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN409_21815 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DN409_21820 ENOG4105N80 Ferric uptake regulator, Fur family DN409_21830 ENOG4105FDK ABC transporter DN409_21835 ENOG4108JYZ YitT family DN409_21840 ENOG41069ZM Protein of unknown function (DUF2624) DN409_21860 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DN409_21865 ENOG4105EGD dinuclear metal center protein, YbgI family DN409_21880 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN409_21885 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DN409_21905 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) DN409_21915 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DN409_21920 ENOG4105KG3 cytidine deaminase DN409_21925 ENOG4107YR5 Diacylglycerol kinase DN409_21930 ENOG4107YVF Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DN409_21935 ENOG4105CTJ Metal Dependent Phosphohydrolase DN409_21940 ENOG4105C9A Phoh family DN409_21950 ENOG41068P3 sporulation protein YqfC DN409_21955 ENOG4105KTH gatB Yqey DN409_21965 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DN409_21970 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DN409_21980 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DN409_22000 ENOG4105CSA Coproporphyrinogen iii oxidase DN409_22005 ENOG4105KVH Transcriptional regulator DN409_22010 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DN409_22020 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) DN409_22025 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) DN409_22030 ENOG4105TQK DNA polymerase iii, delta' subunit DN409_22045 ENOG4108UK2 deaminase DN409_22050 ENOG4105KQC Competence protein DN409_22060 ENOG4105DXX methyltransferase DN409_22070 ENOG4108WF2 Metal Dependent Phosphohydrolase DN409_22075 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DN409_22080 ENOG410812S Rna-binding protein DN409_22085 ENOG4105E2X shikimate dehydrogenase DN409_22090 ENOG4105CQW ribosome biogenesis GTPase YqeH DN409_22095 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DN409_22105 ENOG4105DJ4 phosphatidylserine decarboxylase DN409_22110 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN409_22130 ENOG4105G6Z alkaline phosphatase DN409_22140 ENOG4108MUZ hydrolase DN409_22175 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DN409_22180 ENOG4105MIR Phenylalanine 4-monooxygenase DN409_22185 ENOG4105KZX Pterin carbinolamine dehydratase DN409_22190 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DN409_22230 ENOG4105S6R Iron-hydroxamate transporter permease subunit DN409_22235 ENOG4108V5C ABC transporter DN409_22245 ENOG4108EKI Dehydrogenase DN409_22250 ENOG4105C28 cystathionine DN409_22260 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DN409_22280 ENOG4107XRG penicillin-binding protein DN409_22290 ENOG4105DBI uridine monophosphokinase DN409_22295 ENOG4105CFP Peptidase U32 DN409_22300 ENOG4105XYU peptidase (U32 family) DN409_22305 ENOG4108VQJ O-methyltransferase DN409_22310 ENOG4105HHA aminodeoxychorismate lyase DN409_22320 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DN409_22330 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DN409_22340 ENOG4105C02 permease DN409_22355 ENOG41060CR DN409_22360 ENOG4105C7H Helicase, RecD TraA family DN409_22370 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DN409_22375 ENOG4105C3J Cysteine desulfurase DN409_22385 ENOG4105D1H recombination factor protein RarA DN409_22390 ENOG4108VCI transcription factor, rsfa family DN409_22395 ENOG4105CUZ uba thif-type nad fad binding protein DN409_22405 ENOG4105CUT histidyl-tRNA synthetase DN409_22410 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DN409_22415 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DN409_22420 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DN409_22425 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DN409_22430 ENOG41076HS cation diffusion facilitator family transporter DN409_22435 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DN409_22445 ENOG4105CKP Polysaccharide Biosynthesis Protein DN409_22450 ENOG4108QG2 Membrane DN409_22460 ENOG4105VIE preprotein translocase, subunit YajC DN409_22465 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DN409_22470 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DN409_22475 ENOG41061AI Protein of unknown function (DUF2905) DN409_22480 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DN409_22485 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DN409_22490 ENOG4108HUF Transporter DN409_22515 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DN409_22520 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DN409_22525 ENOG4108IYU L-aspartate oxidase DN409_22540 ENOG4108RPX mosc domain containing protein DN409_22545 ENOG4105CQC Prephenate dehydratase DN409_22565 ENOG4105EWM Histidine kinase DN409_22575 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DN409_22590 ENOG4105X36 (ribosomal) protein DN409_22600 ENOG4105C03 ribonuclease DN409_22620 ENOG4107QMS site-determining protein DN409_22625 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) DN409_22635 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DN409_22640 ENOG4105DFF Rod shape-determining protein mreb DN409_22645 ENOG4105W5Q DNA repair protein (RadC DN409_22650 ENOG4108Z03 MAF-like protein DN409_22665 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DN409_22670 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DN409_22680 ENOG41068KH stage VI sporulation protein D DN409_22685 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DN409_22690 ENOG4105D52 delta-aminolevulinic acid dehydratase DN409_22700 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DN409_22710 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DN409_22715 ENOG4105K56 Transcriptional regulator DN409_22725 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DN409_22735 ENOG4108IUQ atp-dependent protease DN409_22745 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DN409_22760 ENOG4108QCI YvbH-like oligomerisation region DN409_22865 ENOG4105M59 Phosphodiesterase, mj0936 family DN409_22875 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DN409_22880 ENOG4108XJQ germination protein DN409_22890 ENOG4105PFC Transcriptional regulator DN409_22900 ENOG4105DZC cytosine deaminase DN409_22905 ENOG41067S9 phage shock protein C, PspC DN409_22910 ENOG4108JCI Transcriptional regulator DN409_22920 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DN409_22925 ENOG4108Z40 Transcriptional regulator DN409_22930 ENOG4105RHA ABC transporter, permease DN409_22935 ENOG4108IUX (ABC) transporter DN409_22940 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DN409_22945 ENOG4105ER2 Ompa motb domain protein DN409_22950 ENOG4105E14 MotA TolQ exbB proton channel DN409_22960 ENOG4108VXD carboxy-peptidase DN409_22970 ENOG4105E33 succinate dehydrogenase DN409_22980 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DN409_22990 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DN409_22995 ENOG4105K63 Thioredoxin DN409_23000 ENOG4105C10 Electron transfer flavoprotein DN409_23005 ENOG4105BZJ Electron transfer flavoprotein DN409_23010 ENOG41060WC Enoyl-CoA hydratase DN409_23015 ENOG4107Z3H Transcriptional regulator, TetR family DN409_23020 ENOG4105CEY Amp-dependent synthetase and ligase DN409_23065 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN409_23075 ENOG4105DR4 Methyltransferase DN409_23085 ENOG4105P9G heme-degrading monooxygenase IsdG DN409_23090 ENOG4105KFN sortase, SrtB family DN409_23095 ENOG4105E0A ABC, transporter DN409_23110 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) DN409_23120 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DN409_23130 ENOG4105FE9 pseudouridine synthase DN409_23135 ENOG4105C98 muts2 protein DN409_23140 ENOG4105DCG PHP domain protein DN409_23150 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) DN409_23155 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DN409_23175 ENOG4105C5S asparaginyl-tRNA synthetase DN409_23180 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DN409_23185 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DN409_23190 ENOG4108RWN rrna methyltransferase DN409_23225 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN409_23230 ENOG4105CW7 secretion protein, HlyD family DN409_23235 ENOG4108JGH Tetr family transcriptional regulator DN409_23240 ENOG4105CN9 Peptidase m42 family protein DN409_23250 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DN409_23260 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DN409_23265 ENOG4105C22 threonyL-tRNA synthetase DN409_23270 ENOG4108TDW sporulation protein YtxC DN409_23290 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DN409_23295 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DN409_23300 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DN409_23315 ENOG4105C2M dna polymerase I DN409_23320 ENOG4105BZU Histidine kinase DN409_23325 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN409_23340 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN409_23345 ENOG4108HMX isocitrate dehydrogenase (NADP) DN409_23350 ENOG4105BZN citrate synthase DN409_23365 ENOG4108REF Sporulation integral membrane protein ytvi DN409_23370 ENOG4105FS0 cytoplasmic membrane protein DN409_23375 ENOG4105CA9 Pyruvate kinase DN409_23380 ENOG4105CTQ phosphohexokinase DN409_23390 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) DN409_23395 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DN409_23400 ENOG4105C6K Malic enzyme DN409_23405 ENOG4105C0B DNA polymerase III (alpha subunit) DN409_23410 ENOG4105VV2 DN409_23420 ENOG4105SFS phosphoesterase RecJ domain protein DN409_23455 ENOG4105E8R UPF0173 metal-dependent hydrolase DN409_23460 ENOG4105DC7 peptidase M24 DN409_23485 ENOG41082W1 Cupin 2, conserved barrel domain protein DN409_23495 ENOG4105VZ8 Transcriptional regulator DN409_23515 ENOG4107YZX Universal stress protein DN409_23535 ENOG4105CH7 arginosuccinase DN409_23540 ENOG4105CDH Citrulline--aspartate ligase DN409_23555 ENOG4108JYZ YitT family DN409_23575 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DN409_23585 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DN409_23590 ENOG4105KBJ sporulation protein ytfj DN409_23605 ENOG4105EFZ amidohydrolase DN409_23615 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DN409_23650 ENOG4105U5Y Transcriptional regulator DN409_23660 ENOG4105C28 cystathionine DN409_23665 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DN409_23690 ENOG4105EMN RNA polymerase sigma factor DN409_23700 ENOG4108UW5 maltose o-acetyltransferase DN409_23705 ENOG4105WQG acetyltransferase DN409_23715 ENOG4105F1V Acetoin utilization protein DN409_23720 ENOG4105W87 Cbs domain DN409_23725 ENOG4105DGU Histone deacetylase DN409_23730 ENOG4106HB6 Alpha beta hydrolase DN409_23740 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN409_23745 ENOG4105BZU Histidine kinase DN409_23750 ENOG4107SNB ankyrin repeat protein YahD DN409_23755 ENOG4105EP9 oxidoreductase DN409_23760 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) DN409_23780 ENOG4105ETE Transcriptional regulator (LacI family DN409_23785 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DN409_23790 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DN409_23810 ENOG4105C88 aminopeptidase DN409_23835 ENOG4105DFU Cell wall formation (By similarity) DN409_23860 ENOG4108VDD TRNA binding domain protein DN409_23890 ENOG4105C8F Beta-lactamase domain protein DN409_23895 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DN409_23905 ENOG4108V15 phosphotransferase enzyme family DN409_23910 ENOG4108IUM Glycogen debranching enzyme DN409_23920 ENOG4107QSE Dipeptidase DN409_23925 ENOG4105YW5 deoR family transcriptional regulator DN409_23940 ENOG4105CBX hi0933 family DN409_23975 ENOG4108VJ1 Transcriptional regulator (CarD family DN409_23980 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DN409_24000 ENOG4108ZAF Molybdopterin DN409_24005 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DN409_24010 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN409_24020 ENOG4105D06 uba thif-type nad fad binding protein DN409_24025 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DN409_24050 ENOG41085GJ domain protein DN409_24060 ENOG4105DWV Homoserine O-trans-acetylase DN409_24070 ENOG4108B31 Spore germination protein DN409_24105 ENOG410605W Major Facilitator DN409_24110 ENOG4107S91 Sodium hydrogen exchanger DN409_24115 ENOG4105NCW Trka-c domain protein DN409_24130 ENOG4105C19 ABC transporter DN409_24145 ENOG4105N5T Radical SAM Protein DN409_24170 ENOG4105E8V Alpha Beta Hydrolase Fold protein DN409_24175 ENOG4108Z0R Transferase DN409_24180 ENOG4105YVM Phosphoesterase, PA-phosphatase related DN409_24185 ENOG4105BZF Glycosyl transferase (Group 1 DN409_24195 ENOG4105D7V transposase DN409_24200 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) DN409_24205 ENOG4105EPU Molybdenum cofactor synthesis domain protein DN409_24220 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DN409_24225 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase DN409_24270 ENOG4105BZU Histidine kinase DN409_24275 ENOG4105BZU Histidine kinase DN409_24280 ENOG4105CH6 catalase DN409_24285 ENOG4107S9D Alpha beta hydrolase DN409_24295 ENOG4107T7U Sulfatase DN409_24320 ENOG4105D2X ABC transporter substrate-binding protein DN409_24330 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DN409_24345 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DN409_24400 ENOG41080TC multidrug resistance protein DN409_24405 ENOG410839T multidrug resistance protein DN409_24425 ENOG4108V2W Carbonate dehydratase DN409_24430 ENOG4105C4M (Ubiquinol oxidase) subunit I DN409_24435 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DN409_24475 ENOG41087YS Phage shock protein A DN409_24500 ENOG4105N67 Proton-coupled thiamine transporter YuaJ DN409_24505 ENOG4105BZU Histidine kinase DN409_24510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_24535 ENOG4108UGV hypoxanthine phosphoribosyltransferase DN409_24540 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DN409_24580 ENOG4107ZTW SNARE associated Golgi DN409_24600 ENOG4105C19 ABC transporter DN409_24605 ENOG41086D8 Transcriptional regulator DN409_24615 ENOG4105CJ1 ABC, transporter DN409_24625 ENOG41082BM Transcriptional regulator, arsr family DN409_24665 ENOG4105C6Z Gluconate DN409_24670 ENOG4105FDP GntR family transcriptional regulator DN409_24690 ENOG41069H0 dihydroorotase EC 3.5.2.3 DN409_24710 ENOG4105DTQ mandelate racemase muconate lactonizing DN409_24715 ENOG4105CEY Amp-dependent synthetase and ligase DN409_24720 ENOG4108IPT Naphthoate synthase DN409_24725 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DN409_24730 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DN409_24735 ENOG4105E4F Isochorismate synthase DN409_24740 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DN409_24750 ENOG4105VEQ Cold shock protein DN409_24760 ENOG4107SWG transcriptional regulator MERR family DN409_24785 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DN409_24800 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN409_24940 ENOG4105KT7 mgtC SapB transporter DN409_24945 ENOG4107PBV potassium channel DN409_24955 ENOG4107S5H glucose-6-phosphate isomerase DN409_24965 ENOG4105WG9 Conserved Protein DN409_24975 ENOG4105CHM Aminotransferase DN409_24980 ENOG4108ZB6 transcriptional regulator AsnC family DN409_24985 ENOG4105C5I Dehydrogenase DN409_24990 ENOG4108MUZ hydrolase DN409_25000 ENOG4105C87 Aminotransferase class I and II DN409_25010 ENOG4105Y38 Kinase-associated protein B DN409_25020 ENOG4107R3E Citrate transporter DN409_25035 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DN409_25040 ENOG4105KA0 thioesterase Superfamily protein DN409_25055 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DN409_25070 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DN409_25075 ENOG41069ER domain protein DN409_25090 ENOG4105CEP NADH dehydrogenase DN409_25115 ENOG4105EWC Purine nucleoside phosphorylase DN409_25140 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DN409_25145 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) DN409_25165 ENOG4105C4B ABC transporter, permease DN409_25170 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DN409_25200 ENOG41083MR nifu domain-containing protein DN409_25215 ENOG4108W5N phosphatidylglycerophosphatase a DN409_25235 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DN409_25240 ENOG4105DYS nad(p)h dehydrogenase (quinone) DN409_25250 ENOG4105D4U had-superfamily hydrolase, subfamily iia DN409_25265 ENOG4105CBT Fructose-1,6-bisphosphatase DN409_25285 ENOG4105MMD transcriptional regulator DN409_25290 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DN409_25295 ENOG4107TXC Transcriptional regulator DN409_25300 ENOG41090T1 Membrane DN409_25320 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DN409_25325 ENOG4105FAA peptidase M23 DN409_25330 ENOG4108YTE sporulation protein YunB DN409_25335 ENOG4105KZD Domain of unknown function (DUF1805) DN409_25340 ENOG4107R8B 5'-nucleotidase DN409_25345 ENOG4105DIW FeS assembly protein SUFB DN409_25350 ENOG4108UNV SUF system FeS assembly protein, NifU family DN409_25355 ENOG4105C9B Cysteine desulfurase DN409_25360 ENOG4105JRK feS assembly protein SufD DN409_25365 ENOG4105C3K feS assembly ATPase SufC DN409_25370 ENOG4105D01 (LipO)protein DN409_25375 ENOG4105D01 (LipO)protein DN409_25380 ENOG4108UMI ABC transporter, permease DN409_25405 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DN409_25410 ENOG41080E8 Transcriptional regulator, Spx MgsR family DN409_25450 ENOG4108W8B Beta-lactamase domain protein DN409_25455 ENOG4105C1G acyl-Coa dehydrogenase DN409_25460 ENOG4105CHU acetyl-coa acetyltransferase DN409_25475 ENOG4105DZ1 carboxypeptidase DN409_25495 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DN409_25510 ENOG4108SUT Major Facilitator Superfamily DN409_25515 ENOG4107R7I amino acid DN409_25530 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DN409_25540 ENOG4107AYK membrAne DN409_25570 ENOG4107ZTW SNARE associated Golgi DN409_25580 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DN409_25585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_25590 ENOG4105BZU Histidine kinase DN409_25600 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DN409_25610 ENOG4105C8Q Methyl-accepting chemotaxis DN409_25615 ENOG4105C8Q Methyl-accepting chemotaxis DN409_25620 ENOG4105VG1 fes assembly suf system protein DN409_25625 ENOG4105D4Y metalloprotease DN409_25645 ENOG4107T5V SNARE associated Golgi DN409_25650 ENOG4107S91 Sodium hydrogen exchanger DN409_25655 ENOG4105NCW Trka-c domain protein DN409_25665 ENOG4108RMU ferritin dps family protein DN409_25680 ENOG4108URH decarboxylase DN409_25690 ENOG41090A1 ferritin DN409_25700 ENOG4105D9N nucleoside DN409_25705 ENOG4105D9N nucleoside DN409_25715 ENOG4108RYK Nad-dependent epimerase dehydratase DN409_25745 ENOG4105CV8 reductase DN409_25750 ENOG4105F27 Major Facilitator DN409_25755 ENOG4105KVH Transcriptional regulator DN409_25770 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DN409_25775 ENOG4105D4A Cell wall formation (By similarity) DN409_25785 ENOG4105C8Q Methyl-accepting chemotaxis DN409_25795 ENOG4105WMR Protein CrcB homolog DN409_25800 ENOG4105WMR Protein CrcB homolog DN409_25810 ENOG4105VMP Transcriptional regulator DN409_25825 ENOG4108MK9 spermidine N(1)-acetyltransferase DN409_25830 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DN409_25835 ENOG4105KVH Transcriptional regulator DN409_25845 ENOG4105DEN Luciferase family DN409_25850 ENOG4105VPS UPF0291 protein DN409_25860 ENOG4108V2W Carbonate dehydratase DN409_25865 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) DN409_25880 ENOG4108IPW abc transporter atp-binding protein DN409_25885 ENOG4105CM4 permease protein DN409_25930 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DN409_25940 ENOG4105XZU Preprotein translocase, subunit SecG DN409_25945 ENOG41067MG lrgb family DN409_25955 ENOG4105DU0 nucleoside hydrolase DN409_25960 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DN409_25970 ENOG4105CP7 Triose-phosphate isomerase DN409_25975 ENOG4105BZA Phosphoglycerate kinase DN409_25995 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN409_26015 ENOG41090VF Stage v sporulation protein ac DN409_26020 ENOG4105CZ3 stage V sporulation protein ad DN409_26035 ENOG4108QY0 Membrane DN409_26040 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DN409_26050 ENOG4105KRI phosphocarrier protein (HPr DN409_26055 ENOG4105CIE May be required for sporulation (By similarity) DN409_26060 ENOG4105CHW UPF0052 protein DN409_26065 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DN409_26070 ENOG4108Z4K mutator MutT protein DN409_26080 ENOG4105C3M thioredoxin reductase DN409_26090 ENOG4108S4C acetyltransferase DN409_26095 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DN409_26100 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) DN409_26105 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) DN409_26110 ENOG41086DT Membrane protein of unknown function DN409_26120 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DN409_26145 ENOG4107TXC Transcriptional regulator DN409_26180 ENOG4105DUM transcriptional regulator, lysR family DN409_26190 ENOG4108WS4 fmn reductase DN409_26205 ENOG4105BZ1 (ABC) transporter DN409_26215 ENOG4105CN1 protease DN409_26220 ENOG4105CRP Part of the ABC transporter FtsEX involved in DN409_26225 ENOG4105CAK Cell division ATP-binding protein ftsE DN409_26260 ENOG4105MS2 ribosomal subunit Interface protein DN409_26265 ENOG4105VEQ Cold shock protein DN409_26270 ENOG41081UC Inherit from COG: Competence protein DN409_26285 ENOG4105KVH Transcriptional regulator DN409_26295 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DN409_26300 ENOG4108KGH TRANSCRIPTIONal DN409_26305 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DN409_26310 ENOG4105C6Y Udp-glucose 6-dehydrogenase DN409_26315 ENOG4105ESV Glycosyl transferase, family 4 DN409_26325 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DN409_26345 ENOG4105F8D glycoside hydrolase family 4 DN409_26350 ENOG4105VCP PTS System DN409_26355 ENOG4105CK1 PTS System DN409_26365 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DN409_26375 ENOG4105VCP PTS System DN409_26385 ENOG4105VZJ PTS System DN409_26405 ENOG4105ECB domain protein DN409_26410 ENOG4107RSM transcriptional regulator DN409_26435 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DN409_26440 ENOG4105DAA L-lactate DN409_26450 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) DN409_26465 ENOG4105E0M Sulfatase DN409_26490 ENOG4107R8N Glycosyl transferase, family 2 DN409_26495 ENOG4105C94 Transporter DN409_26505 ENOG41069ER domain protein DN409_26530 ENOG4105KBK Zinc finger, swim domain protein DN409_26535 ENOG4105C0D helicase DN409_26575 ENOG4107RBB ABC transporter, permease DN409_26580 ENOG4105C19 ABC transporter DN409_26605 ENOG4105CXY transporter DN409_26620 ENOG41062D9 Histidine kinase DN409_26625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_26635 ENOG4108KGH TRANSCRIPTIONal DN409_26655 ENOG4105BZF Glycosyl transferase (Group 1 DN409_26670 ENOG4108TMJ glycosyl transferase DN409_26675 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DN409_26685 ENOG4105C5E polysaccharide biosynthesis protein DN409_26695 ENOG4105D7W serine acetyltransferase DN409_26700 ENOG4105D3Q Sugar transferase DN409_26705 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DN409_26715 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DN409_26720 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DN409_26725 ENOG4107YJ4 chain length determinant protein DN409_26730 ENOG4105HTX biosynthesis protein DN409_26735 ENOG4107YJ4 chain length determinant protein DN409_26750 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DN409_26760 ENOG4105FRN stage II sporulation protein DN409_26775 ENOG4105DY9 regulatoR DN409_26795 ENOG4106778 Protein of unknown function (DUF1146) DN409_26800 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DN409_26805 ENOG4105C8S subunit m DN409_26810 ENOG4105D65 subunit l DN409_26815 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DN409_26830 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) DN409_26835 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DN409_26840 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DN409_26845 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DN409_26850 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DN409_26855 ENOG4105BZU Histidine kinase DN409_26875 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DN409_26880 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DN409_26885 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DN409_26890 ENOG4107XXH F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DN409_26895 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) DN409_26905 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DN409_26930 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DN409_26940 ENOG4108YZG isomerase DN409_26955 ENOG4108VGI doxx family DN409_26960 ENOG4107XC4 flavin reductase domain protein, FMN-binding DN409_26975 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DN409_26985 ENOG4108ZXQ stage ii sporulation protein r DN409_26990 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DN409_27000 ENOG4107104 thymidine kinase DN409_27015 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DN409_27020 ENOG4105CBT Fructose-1,6-bisphosphatase DN409_27025 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DN409_27045 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DN409_27060 ENOG4105C1G acyl-Coa dehydrogenase DN409_27065 ENOG4105C1G acyl-Coa dehydrogenase DN409_27070 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DN409_27080 ENOG4105DF6 Fe-S oxidoreductase DN409_27090 ENOG4105E5J UV damage endonuclease DN409_27095 ENOG4105BZU Histidine kinase DN409_27110 ENOG4105D4Y metalloprotease DN409_27120 ENOG4105BZU Histidine kinase DN409_27125 ENOG4105KCT ABC transporter DN409_27130 ENOG4108M15 ABC transporter DN409_27135 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DN409_27145 ENOG4105IIU Aminopeptidase DN409_27165 ENOG410684U Domain of unknown function (DUF1934) DN409_27190 ENOG4105CYW agmatinase DN409_27195 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DN409_27200 ENOG4105DXB Major Facilitator superfamily DN409_27205 ENOG4107SWG transcriptional regulator MERR family DN409_27210 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DN409_27215 ENOG4105BZ4 penicillin-binding protein DN409_27220 ENOG4108XFG YwhD family DN409_27225 ENOG4108Z4T Peptidase M50 DN409_27230 ENOG41069HH 4-oxalocrotonate tautomerase DN409_27235 ENOG4105DCI Phosphohydrolase DN409_27240 ENOG4108MES Periplasmic binding protein DN409_27245 ENOG4105E0A ABC, transporter DN409_27250 ENOG4105EHG Permease protein DN409_27255 ENOG4105DQ5 transport system permease protein DN409_27265 ENOG4108VCI transcription factor, rsfa family DN409_27270 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DN409_27275 ENOG4108IJ2 phosphate acetyltransferase DN409_27280 ENOG4107JTW chlorite dismutase DN409_27290 ENOG4108VKI Cell wall hydrolase DN409_27320 ENOG410667J hydrolase DN409_27325 ENOG4105VCH membrane DN409_27330 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DN409_27335 ENOG4108TU7 Inherit from COG: (ABC) transporter DN409_27340 ENOG4105CJ1 ABC, transporter DN409_27345 ENOG41090WU lipolytic protein G-D-S-L family DN409_27360 ENOG4105D6E homoserine dehydrogenase DN409_27365 ENOG4105CVG Homoserine O-transsuccinylase DN409_27385 ENOG4108Y4K DNA-binding transcriptional activator DN409_27395 ENOG4105WH1 Two component transcriptional regulator luxr family DN409_27400 ENOG4105BZU Histidine kinase DN409_27405 ENOG4105DWF phosphomethylpyrimidine kinase DN409_27410 ENOG4105BZU Histidine kinase DN409_27415 ENOG4105VCD cytoplasmic protein DN409_27420 ENOG4105D22 carbon starvation protein DN409_27425 ENOG4105DY9 regulatoR DN409_27430 ENOG41079KZ Major Facilitator Superfamily DN409_27440 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) DN409_27450 ENOG4105EN6 Membrane DN409_27455 ENOG4106YBV Methyl-accepting chemotaxis DN409_27465 ENOG4108S4H thioesterase Superfamily protein DN409_27470 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) DN409_27480 ENOG4105K64 Glycosyl transferase, family 2 DN409_27490 ENOG4105C5H ABC transporter DN409_27495 ENOG41067SE Tetr family transcriptional regulator DN409_27505 ENOG4105E0X reductase DN409_27510 ENOG4106F5Q Membrane DN409_27520 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) DN409_27525 ENOG4105DY9 regulatoR DN409_27530 ENOG4108HRK Histidine kinase DN409_27535 ENOG4107RGD Major Facilitator superfamily DN409_27555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN409_27565 ENOG4105IW1 AmiS UreI transporter DN409_27605 ENOG4105CMR udp-glucose 4-epimerase DN409_27610 ENOG4108UT2 hemolysin iii DN409_27620 ENOG4105C1J atp-dependent rna helicase DN409_27630 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) DN409_27635 ENOG4105DPN Oligoendopeptidase f DN409_27645 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DN409_27655 ENOG4105C0H protease DN409_27660 ENOG4105Q2H domain protein DN409_27675 ENOG4105BZU Histidine kinase DN409_27680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_27705 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DN409_27710 ENOG4105CDU Replicative dna helicase DN409_27715 ENOG4105K9Q Binds to the 23S rRNA (By similarity) DN409_27720 ENOG4105BZR domain protein DN409_27725 ENOG4108XMW Membrane DN409_27735 ENOG4108UUM single-stranded DNA-binding protein DN409_27740 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DN409_27745 ENOG4105C3G gtp-binding protein DN409_27750 ENOG4105VDK protein, conserved in bacteria DN409_27755 ENOG4105D8X mechanosensitive ion channel DN409_27760 ENOG4108ZDA Sporulation protein YyaC DN409_27765 ENOG4105FA0 parb-like partition protein DN409_27770 ENOG4107QJE Chromosome Partitioning Protein DN409_27775 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) DN409_27785 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DN409_27790 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DN409_27800 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DN409_27805 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DN409_27830 ENOG4105BZU Histidine kinase DN409_27850 ENOG4105D7V transposase DN409_27910 ENOG4108RCM Nitroreductase DN409_27950 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DN409_27965 ENOG4105CNU cell division protein FtsK DN409_28105 ENOG4105CAQ asparagine synthetase DN409_28115 ENOG4105D7V transposase DN409_28155 ENOG4105DR5 peptidase DN409_28185 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis DN409_28210 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DN409_28215 ENOG4107RRE RNA-directed DNA polymerase DN409_28230 ENOG4105EXC Acyl-transferase DN409_28250 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DN409_28315 ENOG4105C5E polysaccharide biosynthesis protein DN409_28320 ENOG4105C1B dTDP-glucose 4-6-dehydratase DN409_28325 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DN409_28330 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) DN409_28455 ENOG4105KRN Transcriptional regulator, abrb family DN409_28465 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DN409_28515 ENOG4105W8Z 4'-phosphopantetheinyl transferase DN409_28535 ENOG4105KRN Transcriptional regulator, abrb family DN409_28605 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DN409_28615 ENOG4105C6X Major Facilitator DN409_28660 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DN409_28685 ENOG4105K4H Nlp p60 protein DN409_28700 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DN409_28710 ENOG4105EGI Transcriptional regulator DN409_28715 ENOG4107RF6 penicillin-binding protein DN409_28730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_28735 ENOG4105BZU Histidine kinase DN409_28740 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C DN409_28755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN409_28780 ENOG4105D7V transposase DN409_28785 ENOG4108IQI permease DN409_28800 ENOG4107S9D Alpha beta hydrolase DN409_28810 ENOG4105K70 DNA-binding protein DN409_28820 ENOG4105C8Q Methyl-accepting chemotaxis DN409_28845 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF DN409_28860 ENOG4106PZP Bacillus haemolytic enterotoxin (HBL) DN409_28890 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) DN409_28905 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DN409_28920 ENOG4105KRN Transcriptional regulator, abrb family DN409_28925 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DN409_28980 ENOG4105CIF Ornithine Cyclodeaminase DN409_28995 ENOG4105CDH Citrulline--aspartate ligase DN409_29025 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DN409_29035 ENOG4105C1G acyl-Coa dehydrogenase DN409_29065 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN409_29085 ENOG4105CHM Aminotransferase DN409_29125 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DN409_29140 ENOG4105D1H recombination factor protein RarA DN409_29155 ENOG4105C1G acyl-Coa dehydrogenase DN409_29170 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN409_29180 ENOG4105XRQ Xanthine dehydrogenase accessory factor DN409_29210 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DN409_29215 ENOG4108S0S Nucleotidyl transferase DN409_29220 ENOG4105CG5 Glycosyl transferase (Group 1 DN409_29230 ENOG4108IJ1 Dehydrogenase DN409_29245 ENOG4105C6T cysteine synthase DN409_29255 ENOG4105CJ1 ABC, transporter DN409_29270 ENOG4105D29 Helix-turn-helix type 11 domain protein DN409_29305 ENOG4105K70 DNA-binding protein DN409_29370 ENOG4105ED2 Beta-lactamase DN409_29375 ENOG4105D7V transposase DN409_29380 ENOG4108RWP Major Facilitator Superfamily protein DN409_29385 ENOG4105GZI Transcriptional regulator DN409_29480 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN409_29485 ENOG41062JF Transcriptional regulator DN409_29490 ENOG4105FQP Beta-lactamase DN409_29500 ENOG4105CRW Short chain fatty acid transporter DN409_29720 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DN409_30050 ENOG4107WZZ SMC domain protein DN409_30110 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) DN409_30255 ENOG4105CNU cell division protein FtsK DN409_30290 ENOG41067QW Transcriptional regulator DN409_30385 ENOG4105KIR Thiol-disulfide oxidoreductase dcc DN409_30430 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DN409_30520 ENOG4107QJE Chromosome Partitioning Protein DN409_30540 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DN409_30560 ENOG4105K4H Nlp p60 protein DN409_30630 ENOG4105EC2 ftsk spoIIIe DN409_30650 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DN409_30685 ENOG4105WFK nuclease