locus-tag	class	description
EXW40_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW40_00010	COG0592	DNA-directed DNA polymerase activity
EXW40_00015	COG2501	S4 domain
EXW40_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW40_00025	COG0187	DNA topoisomerase II activity
EXW40_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW40_00065	COG0516	GMP reductase activity
EXW40_00065	COG0517	IMP dehydrogenase activity
EXW40_00070	COG1686	Belongs to the peptidase S11 family
EXW40_00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW40_00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW40_00100	COG1428	Deoxynucleoside kinase
EXW40_00105	COG1428	Deoxynucleoside kinase
EXW40_00110	COG1335	isochorismatase
EXW40_00115	COG0590	tRNA wobble adenosine to inosine editing
EXW40_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW40_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW40_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW40_00180	COG1982	Orn Lys Arg decarboxylase major
EXW40_00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW40_00190	COG0470	DNA polymerase III
EXW40_00195	COG1774	PSP1 C-terminal conserved region
EXW40_00200	COG4467	Involved in initiation control of chromosome replication
EXW40_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW40_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW40_00220	COG2002	toxin-antitoxin pair type II binding
EXW40_00230	COG0084	hydrolase, TatD family'
EXW40_00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW40_00250	COG4466	Protein conserved in bacteria
EXW40_00260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW40_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW40_00270	COG0251	oxidation-reduction process
EXW40_00275	COG2088	sporulation resulting in formation of a cellular spore
EXW40_00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW40_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW40_00305	COG2002	toxin-antitoxin pair type II binding
EXW40_00310	COG2244	polysaccharide biosynthetic process
EXW40_00315	COG3956	TIGRFAM MazG family protein
EXW40_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW40_00340	COG1098	S1 RNA binding domain
EXW40_00355	COG2208	phosphoserine phosphatase activity
EXW40_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW40_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW40_00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW40_00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW40_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW40_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW40_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW40_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW40_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW40_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW40_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW40_00420	COG1396	sequence-specific DNA binding
EXW40_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW40_00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW40_00520	COG3880	PFAM UvrB UvrC protein
EXW40_00525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW40_00530	COG0542	response to heat
EXW40_00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW40_00540	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW40_00545	COG4956	integral membrane protein (PIN domain superfamily)
EXW40_00550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW40_00560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW40_00565	COG1045	serine acetyltransferase
EXW40_00570	COG0215	cysteine-tRNA ligase activity
EXW40_00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW40_00585	COG3688	RNA-binding protein containing a PIN domain
EXW40_00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW40_00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW40_00605	COG0250	Participates in transcription elongation, termination and antitermination
EXW40_00610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW40_00615	COG0081	regulation of translation
EXW40_00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW40_00625	COG0222	ribosome binding
EXW40_00630	COG2813	Specifically methylates the guanine in position
EXW40_00635	COG0085	RNA polymerase activity
EXW40_00640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW40_00645	COG1358	cellular component organization or biogenesis
EXW40_00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW40_00655	COG0049	tRNA binding
EXW40_00660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW40_00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW40_00670	COG0051	transcription antitermination factor activity, RNA binding
EXW40_00675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW40_00680	COG0088	Forms part of the polypeptide exit tunnel
EXW40_00685	COG0089	rRNA binding
EXW40_00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW40_00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW40_00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW40_00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EXW40_00715	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW40_00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW40_00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EXW40_00730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW40_00735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW40_00745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW40_00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW40_00765	COG1841	ribosomal large subunit assembly
EXW40_00770	COG0200	Binds to the 23S rRNA
EXW40_00775	COG0201	protein transport
EXW40_00780	COG0563	adenylate kinase activity
EXW40_00785	COG0024	Methionine aminopeptidase
EXW40_00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW40_00800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW40_00805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW40_00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW40_00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW40_00845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW40_00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW40_00860	COG0489	protein tyrosine kinase activity
EXW40_00870	COG2194	sulfuric ester hydrolase activity
EXW40_00875	COG0726	polysaccharide deacetylase
EXW40_00955	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW40_00960	COG4856	YbbR-like protein
EXW40_00965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW40_00980	COG4946	Tricorn protease homolog
EXW40_00980	COG1506	peptidase
EXW40_00980	COG0823	Involved in the tonB-independent uptake of proteins
EXW40_01005	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_01010	COG2011	ABC-type metal ion transport system permease component
EXW40_01020	COG1464	Belongs to the NlpA lipoprotein family
EXW40_01025	COG0604	alcohol dehydrogenase
EXW40_01035	COG0277	FAD linked oxidase domain protein
EXW40_01040	COG2271	Major facilitator Superfamily
EXW40_01050	COG2814	Major facilitator Superfamily
EXW40_01065	COG0601	transmembrane transport
EXW40_01070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW40_01075	COG0444	Belongs to the ABC transporter superfamily
EXW40_01080	COG4608	Belongs to the ABC transporter superfamily
EXW40_01085	COG4166	transmembrane transport
EXW40_01095	COG2207	Transcriptional regulator
EXW40_01110	COG4166	transmembrane transport
EXW40_01115	COG4166	transmembrane transport
EXW40_01120	COG0656	L-ascorbic acid biosynthetic process
EXW40_01125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW40_01140	COG4149	molybdate abc transporter
EXW40_01145	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW40_01150	COG1910	domain protein
EXW40_01165	COG0697	spore germination
EXW40_01180	COG0204	Acyl-transferase
EXW40_01190	COG1609	Transcriptional regulator
EXW40_01200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW40_01215	COG5298	Protein conserved in bacteria
EXW40_01240	COG0488	(ABC) transporter
EXW40_01250	COG0747	negative chemotaxis
EXW40_01255	COG0747	negative chemotaxis
EXW40_01260	COG0601	transmembrane transport
EXW40_01265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW40_01270	COG0444	Belongs to the ABC transporter superfamily
EXW40_01275	COG4608	Belongs to the ABC transporter superfamily
EXW40_01280	COG0561	phosphatase activity
EXW40_01310	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW40_01315	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW40_01325	COG0531	amino acid
EXW40_01330	COG2814	Major facilitator Superfamily
EXW40_01340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW40_01350	COG4294	response to UV
EXW40_01355	COG0705	Rhomboid family
EXW40_01360	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW40_01365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW40_01370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW40_01375	COG0864	Transcriptional regulator
EXW40_01380	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW40_01385	COG2183	response to ionizing radiation
EXW40_01485	COG0802	atpase or kinase
EXW40_01490	COG1214	PFAM Peptidase M22, glycoprotease
EXW40_01495	COG0456	acetyltransferase
EXW40_01505	COG0488	(ABC) transporter
EXW40_01510	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW40_01520	COG1266	CAAX protease self-immunity
EXW40_01525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW40_01530	COG0459	protein refolding
EXW40_01535	COG0519	Catalyzes the synthesis of GMP from XMP
EXW40_01535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW40_01540	COG2252	PERMEase
EXW40_01550	COG5002	protein histidine kinase activity
EXW40_01580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW40_01610	COG2226	methyltransferase
EXW40_01620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW40_01670	COG2205	protein histidine kinase activity
EXW40_01675	COG0745	RESPONSE REGULATOR receiver
EXW40_01695	COG0697	spore germination
EXW40_01725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW40_01730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW40_01735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW40_01740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW40_01745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW40_01750	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW40_01755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW40_01760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW40_01765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW40_01770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW40_01775	COG0138	bifunctional purine biosynthesis protein purh
EXW40_01780	COG0151	Belongs to the GarS family
EXW40_01805	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW40_01810	COG0210	DNA helicase
EXW40_01815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW40_01820	COG4851	CamS sex pheromone cAM373 precursor
EXW40_01830	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_01835	COG1335	isochorismatase
EXW40_01845	COG2011	ABC-type metal ion transport system permease component
EXW40_01850	COG1464	Belongs to the NlpA lipoprotein family
EXW40_01865	COG0003	Pfam Anion-transporting ATPase
EXW40_01870	COG1846	Transcriptional regulator
EXW40_01875	COG4682	membrane
EXW40_01885	COG0154	amidase activity
EXW40_01890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW40_01895	COG1597	lipid kinase activity
EXW40_01905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW40_01915	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_01920	COG2076	Multidrug Resistance protein
EXW40_01925	COG2309	aminopeptidase activity
EXW40_01940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW40_01950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW40_01955	COG5002	protein histidine kinase activity
EXW40_01970	COG4807	Protein conserved in bacteria
EXW40_01995	COG1757	Na H antiporter
EXW40_02000	COG1473	amidohydrolase
EXW40_02015	COG0450	alkyl hydroperoxide reductase
EXW40_02025	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW40_02035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW40_02040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW40_02045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW40_02055	COG0492	ferredoxin-NADP+ reductase activity
EXW40_02070	COG0166	Belongs to the GPI family
EXW40_02095	COG5002	protein histidine kinase activity
EXW40_02115	COG3541	Predicted nucleotidyltransferase
EXW40_02120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW40_02120	COG0723	plastoquinol--plastocyanin reductase activity
EXW40_02130	COG0765	amino acid transport
EXW40_02135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW40_02145	COG0840	transmembrane signaling receptor activity
EXW40_02150	COG0277	FAD linked oxidase domain protein
EXW40_02155	COG0366	Alpha amylase catalytic
EXW40_02160	COG1263	PTS System
EXW40_02160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW40_02160	COG2190	(PTS) system
EXW40_02180	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW40_02185	COG0352	thiamine-phosphate diphosphorylase activity
EXW40_02190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW40_02205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW40_02210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW40_02215	COG1116	anion transmembrane transporter activity
EXW40_02220	COG0488	(ABC) transporter
EXW40_02255	COG2270	Major facilitator Superfamily
EXW40_02285	COG2310	stress, protein
EXW40_02290	COG2310	stress, protein
EXW40_02295	COG2310	stress, protein
EXW40_02300	COG0861	Integral membrane protein TerC family
EXW40_02310	COG3853	Toxic anion resistance protein (TelA)
EXW40_02320	COG4840	Belongs to the UPF0435 family
EXW40_02325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW40_02335	COG1295	ribonuclease BN
EXW40_02340	COG2217	Heavy metal translocating P-type atpase
EXW40_02345	COG0697	spore germination
EXW40_02370	COG0586	Pfam SNARE associated Golgi protein
EXW40_02385	COG3871	stress protein (general stress protein 26)
EXW40_02390	COG0387	Pfam Sodium calcium exchanger
EXW40_02400	COG0535	radical SAM domain protein
EXW40_02420	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW40_02440	COG3829	transcription factor binding
EXW40_02450	COG0833	amino acid
EXW40_02455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW40_02475	COG2066	Belongs to the glutaminase family
EXW40_02485	COG1263	PTS System
EXW40_02485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW40_02490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW40_02505	COG1216	Glycosyl transferase, family 2
EXW40_02515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW40_02515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW40_02520	COG0463	Glycosyl transferase, family 2
EXW40_02535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW40_02540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW40_02555	COG1228	amidohydrolase
EXW40_02560	COG1090	epimerase
EXW40_02565	COG2137	regulation of response to DNA damage stimulus
EXW40_02590	COG1988	membrane-bound metal-dependent
EXW40_02595	COG1194	a g-specific adenine glycosylase
EXW40_02615	COG3557	Belongs to the UPF0374 family
EXW40_02620	COG1132	(ABC) transporter
EXW40_02625	COG4129	membrane
EXW40_02635	COG0067	glutamate synthase
EXW40_02635	COG0069	glutamate synthase activity
EXW40_02635	COG0070	glutamate synthase
EXW40_02640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW40_02645	COG4555	ABC transporter
EXW40_02665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW40_02670	COG0735	belongs to the Fur family
EXW40_02775	COG4974	Belongs to the 'phage' integrase family
EXW40_02855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW40_02860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW40_02880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW40_02885	COG5001	Diguanylate cyclase
EXW40_02885	COG1716	ATPase activity
EXW40_02890	COG2766	serine protein kinase
EXW40_02895	COG2718	Belongs to the UPF0229 family
EXW40_02910	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW40_02915	COG2268	Band 7 protein
EXW40_02925	COG3290	protein histidine kinase activity
EXW40_02930	COG4565	transcriptional regulatory protein
EXW40_02935	COG2851	Citrate transporter
EXW40_02960	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW40_02965	COG3842	ATPase activity
EXW40_02970	COG1175	transmembrane transport
EXW40_02975	COG0395	ABC-type sugar transport system, permease component
EXW40_02985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW40_02990	COG0745	RESPONSE REGULATOR receiver
EXW40_02995	COG5002	protein histidine kinase activity
EXW40_03005	COG4990	cell redox homeostasis
EXW40_03015	COG3290	protein histidine kinase activity
EXW40_03020	COG4565	transcriptional regulatory protein
EXW40_03025	COG3493	citrate carrier protein
EXW40_03030	COG0281	malic enzyme
EXW40_03040	COG0697	spore germination
EXW40_03045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW40_03055	COG5002	protein histidine kinase activity
EXW40_03060	COG0745	RESPONSE REGULATOR receiver
EXW40_03065	COG0456	acetyltransferase
EXW40_03070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW40_03075	COG3383	formate dehydrogenase (NAD+) activity
EXW40_03080	COG2427	Protein of unknown function (DUF1641)
EXW40_03095	COG0531	amino acid
EXW40_03105	COG0640	Transcriptional regulator
EXW40_03110	COG2217	Heavy metal translocating P-type atpase
EXW40_03115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW40_03125	COG3227	Zinc metalloprotease (Elastase)
EXW40_03145	COG2720	vancomycin resistance protein
EXW40_03150	COG1316	TRANSCRIPTIONal
EXW40_03155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW40_03160	COG0346	lactoylglutathione lyase activity
EXW40_03165	COG1253	flavin adenine dinucleotide binding
EXW40_03170	COG1027	Aspartate ammonia-lyase
EXW40_03175	COG1620	l-lactate permease
EXW40_03180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW40_03200	COG3104	oligopeptide transport
EXW40_03205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW40_03210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW40_03215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW40_03225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW40_03230	COG0156	8-amino-7-oxononanoate synthase activity
EXW40_03235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW40_03245	COG4548	von Willebrand factor, type A
EXW40_03250	COG0714	Associated with various cellular activities
EXW40_03270	COG0531	amino acid
EXW40_03275	COG2188	Transcriptional regulator
EXW40_03280	COG1263	PTS System
EXW40_03280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW40_03285	COG0366	Alpha amylase catalytic
EXW40_03300	COG0697	spore germination
EXW40_03305	COG4585	Histidine kinase
EXW40_03315	COG1404	Belongs to the peptidase S8 family
EXW40_03330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW40_03335	COG1115	amino acid carrier protein
EXW40_03340	COG1126	abc transporter atp-binding protein
EXW40_03345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW40_03350	COG0765	amino acid transport
EXW40_03355	COG0765	amino acid transport
EXW40_03360	COG0833	amino acid
EXW40_03385	COG2378	regulation of single-species biofilm formation
EXW40_03390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW40_03395	COG5002	protein histidine kinase activity
EXW40_03415	COG2814	Major facilitator Superfamily
EXW40_03420	COG0659	secondary active sulfate transmembrane transporter activity
EXW40_03435	COG0747	negative chemotaxis
EXW40_03445	COG0601	transmembrane transport
EXW40_03450	COG4608	Belongs to the ABC transporter superfamily
EXW40_03460	COG2271	Major facilitator Superfamily
EXW40_03465	COG1846	Transcriptional regulator
EXW40_03470	COG0477	Major facilitator Superfamily
EXW40_03475	COG1609	Transcriptional regulator
EXW40_03480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW40_03485	COG1869	D-ribose catabolic process
EXW40_03495	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW40_03500	COG1879	ABC-type sugar transport system periplasmic component
EXW40_03530	COG1063	alcohol dehydrogenase
EXW40_03545	COG3568	Endonuclease Exonuclease Phosphatase
EXW40_03575	COG0840	transmembrane signaling receptor activity
EXW40_03580	COG3583	domain protein
EXW40_03580	COG3584	3D domain protein
EXW40_03585	COG1476	TRANSCRIPTIONal
EXW40_03605	COG3104	oligopeptide transport
EXW40_03610	COG1114	Component of the transport system for branched-chain amino acids
EXW40_03625	COG1113	amino acid transport
EXW40_03630	COG2252	PERMEase
EXW40_03645	COG2153	protein acetylation
EXW40_03655	COG0475	glutathione-regulated potassium exporter activity
EXW40_03655	COG0569	domain protein
EXW40_03670	COG1845	cytochrome c oxidase, subunit III
EXW40_03675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW40_03685	COG0833	amino acid
EXW40_03690	COG4990	cell redox homeostasis
EXW40_03705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW40_03710	COG0697	spore germination
EXW40_03715	COG0531	amino acid
EXW40_03725	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW40_03730	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW40_03740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW40_03745	COG0573	inorganic phosphate transmembrane transporter activity
EXW40_03750	COG0581	inorganic phosphate transmembrane transporter activity
EXW40_03760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW40_03880	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW40_03895	COG4991	sh3 domain protein
EXW40_03895	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW40_03895	COG3103	Sh3 type 3 domain protein
EXW40_03900	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW40_03905	COG1116	anion transmembrane transporter activity
EXW40_03910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW40_03915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW40_03920	COG0352	thiamine-phosphate diphosphorylase activity
EXW40_03925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW40_03930	COG2104	thiamine diphosphate biosynthetic process
EXW40_03940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW40_03945	COG0351	phosphomethylpyrimidine kinase
EXW40_03970	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXW40_03975	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW40_03980	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW40_03985	COG2205	protein histidine kinase activity
EXW40_03990	COG2814	Major facilitator Superfamily
EXW40_03995	COG1846	Transcriptional regulator
EXW40_04015	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW40_04020	COG1129	ABC transporter
EXW40_04025	COG1879	ABC-type sugar transport system periplasmic component
EXW40_04030	COG2252	PERMEase
EXW40_04035	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_04095	COG0778	Nitroreductase
EXW40_04100	COG2719	SpoVR family
EXW40_04135	COG1937	Protein conserved in bacteria
EXW40_04140	COG0425	Belongs to the sulfur carrier protein TusA family
EXW40_04140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW40_04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW40_04145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW40_04150	COG0425	Belongs to the sulfur carrier protein TusA family
EXW40_04155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW40_04155	COG0425	Belongs to the sulfur carrier protein TusA family
EXW40_04160	COG2210	Belongs to the sulfur carrier protein TusA family
EXW40_04165	COG0730	response to heat
EXW40_04175	COG1316	TRANSCRIPTIONal
EXW40_04195	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW40_04215	COG3711	transcriptional antiterminator
EXW40_04215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW40_04220	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW40_04225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW40_04250	COG3584	3D domain protein
EXW40_04250	COG1388	LysM domain
EXW40_04255	COG0577	efflux transmembrane transporter activity
EXW40_04260	COG1136	(ABC) transporter
EXW40_04270	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW40_04285	COG0577	efflux transmembrane transporter activity
EXW40_04290	COG1114	Component of the transport system for branched-chain amino acids
EXW40_04295	COG3546	catalase activity
EXW40_04320	COG0586	Pfam SNARE associated Golgi protein
EXW40_04355	COG0531	amino acid
EXW40_04360	COG0475	glutathione-regulated potassium exporter activity
EXW40_04370	COG1737	Transcriptional regulator
EXW40_04375	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW40_04380	COG1263	PTS System
EXW40_04380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW40_04390	COG2259	Doxx family
EXW40_04410	COG0697	spore germination
EXW40_04415	COG1522	sequence-specific DNA binding
EXW40_04425	COG0300	oxidoreductase activity
EXW40_04440	COG2076	Multidrug Resistance protein
EXW40_04445	COG1309	transcriptional regulator
EXW40_04450	COG2814	Major facilitator Superfamily
EXW40_04455	COG1733	regulation of RNA biosynthetic process
EXW40_04480	COG0693	protein deglycase activity
EXW40_04490	COG0531	amino acid
EXW40_04495	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_04510	COG1132	(ABC) transporter
EXW40_04515	COG1132	(ABC) transporter
EXW40_04520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW40_04525	COG0765	amino acid transport
EXW40_04530	COG1126	abc transporter atp-binding protein
EXW40_04545	COG0189	ligase activity
EXW40_04555	COG4399	Belongs to the UPF0754 family
EXW40_04560	COG3679	Belongs to the UPF0342 family
EXW40_04575	COG0028	Belongs to the TPP enzyme family
EXW40_04580	COG3527	Alpha-acetolactate decarboxylase
EXW40_04585	COG0463	Glycosyl transferase, family 2
EXW40_04590	COG1216	Glycosyl transferase, family 2
EXW40_04595	COG2094	Belongs to the DNA glycosylase MPG family
EXW40_04600	COG0561	phosphatase activity
EXW40_04610	COG3409	Peptidoglycan-binding domain 1 protein
EXW40_04610	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW40_04615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW40_04620	COG0318	PFAM AMP-dependent synthetase and ligase
EXW40_04625	COG0586	Pfam SNARE associated Golgi protein
EXW40_04635	COG0789	Transcriptional regulator
EXW40_04635	COG4978	Transcriptional regulator
EXW40_04645	COG0659	secondary active sulfate transmembrane transporter activity
EXW40_04660	COG0653	protein targeting
EXW40_04665	COG2244	polysaccharide biosynthetic process
EXW40_04675	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW40_04680	COG4196	transglutaminase domain protein
EXW40_04705	COG1024	Enoyl-CoA hydratase
EXW40_04725	COG1363	Peptidase, m42
EXW40_04740	COG2318	DinB family
EXW40_04760	COG0579	oxidoreductase
EXW40_04815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW40_04820	COG0444	Belongs to the ABC transporter superfamily
EXW40_04825	COG4608	Belongs to the ABC transporter superfamily
EXW40_04845	COG0477	Major facilitator Superfamily
EXW40_04850	COG3290	protein histidine kinase activity
EXW40_04855	COG4565	transcriptional regulatory protein
EXW40_04860	COG3181	Tripartite tricarboxylate transporter family receptor
EXW40_04885	COG2801	Transposase and inactivated derivatives
EXW40_04930	COG0305	Participates in initiation and elongation during chromosome replication
EXW40_04960	COG0477	Major facilitator Superfamily
EXW40_05000	COG2814	Major facilitator Superfamily
EXW40_05005	COG0640	Transcriptional regulator
EXW40_05040	COG2376	Dihydroxyacetone kinase
EXW40_05055	COG2376	Dihydroxyacetone kinase
EXW40_05080	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW40_05100	COG2720	vancomycin resistance protein
EXW40_05150	COG0825	malonyl-CoA metabolic process
EXW40_05170	COG3237	CsbD-like
EXW40_05190	COG2172	sigma factor antagonist activity
EXW40_05195	COG1191	sigma factor activity
EXW40_05205	COG2208	phosphoserine phosphatase activity
EXW40_05210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW40_05215	COG0784	Response regulator, receiver
EXW40_05215	COG2205	protein histidine kinase activity
EXW40_05215	COG5002	protein histidine kinase activity
EXW40_05245	COG2807	transmembrane transport
EXW40_05260	COG4585	Histidine kinase
EXW40_05265	COG2197	response regulator
EXW40_05295	COG0420	3'-5' exonuclease activity
EXW40_05300	COG4717	serine-type aminopeptidase activity
EXW40_05305	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW40_05350	COG0346	lactoylglutathione lyase activity
EXW40_05355	COG0346	lactoylglutathione lyase activity
EXW40_05360	COG0457	Tetratricopeptide repeat
EXW40_05370	COG2267	carboxylic ester hydrolase activity
EXW40_05385	COG3620	sequence-specific DNA binding
EXW40_05405	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW40_05410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW40_05415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW40_05420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW40_05425	COG1695	Transcriptional regulator
EXW40_05445	COG0693	protein deglycase activity
EXW40_05450	COG1595	DNA-templated transcription, initiation
EXW40_05470	COG3973	AAA domain
EXW40_05475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW40_05490	COG1846	Transcriptional regulator
EXW40_05500	COG0537	adenosine 5'-monophosphoramidase activity
EXW40_05505	COG1131	(ABC) transporter
EXW40_05510	COG4473	ABC transporter
EXW40_05520	COG0247	lactate metabolic process
EXW40_05525	COG1139	Iron-sulfur cluster binding protein
EXW40_05530	COG1556	Lactate utilization protein
EXW40_05545	COG3402	PFAM membrane-flanked domain
EXW40_05550	COG3428	Bacterial PH domain
EXW40_05590	COG3402	PFAM membrane-flanked domain
EXW40_05595	COG3428	Bacterial PH domain
EXW40_05600	COG2329	Antibiotic biosynthesis monooxygenase
EXW40_05605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW40_05610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW40_05615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW40_05620	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW40_05640	COG1309	transcriptional regulator
EXW40_05645	COG1511	domain protein
EXW40_05680	COG1609	Transcriptional regulator
EXW40_05690	COG1234	tRNA 3'-trailer cleavage
EXW40_05695	COG0095	Lipoate-protein ligase
EXW40_05705	COG0318	PFAM AMP-dependent synthetase and ligase
EXW40_05720	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW40_05730	COG4208	sulfate ABC transporter
EXW40_05775	COG1408	metallophosphoesterase
EXW40_05780	COG1078	dGTPase activity
EXW40_05795	COG1595	DNA-templated transcription, initiation
EXW40_05805	COG2207	Transcriptional regulator
EXW40_05805	COG3708	Transcriptional regulator
EXW40_05810	COG2205	protein histidine kinase activity
EXW40_05815	COG0745	RESPONSE REGULATOR receiver
EXW40_05835	COG0501	Belongs to the peptidase M48B family
EXW40_05840	COG0840	transmembrane signaling receptor activity
EXW40_05845	COG0697	spore germination
EXW40_05875	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW40_05880	COG2224	Isocitrate lyase
EXW40_05890	COG1278	Cold shock
EXW40_05905	COG4903	ComK protein
EXW40_05915	COG0398	Pfam SNARE associated Golgi protein
EXW40_05925	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW40_05930	COG1074	ATP-dependent DNA helicase activity
EXW40_05980	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW40_06005	COG0367	asparagine synthase
EXW40_06015	COG0753	catalase activity
EXW40_06020	COG0004	ammonium transporteR
EXW40_06030	COG1666	GTP binding
EXW40_06035	COG2996	Protein conserved in bacteria
EXW40_06045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW40_06070	COG0561	phosphatase activity
EXW40_06090	COG2267	carboxylic ester hydrolase activity
EXW40_06105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW40_06110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW40_06115	COG5504	Zn-dependent protease
EXW40_06130	COG0180	Tryptophanyl-tRNA synthetase
EXW40_06145	COG4166	transmembrane transport
EXW40_06150	COG0601	transmembrane transport
EXW40_06155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW40_06160	COG0444	Belongs to the ABC transporter superfamily
EXW40_06165	COG4608	Belongs to the ABC transporter superfamily
EXW40_06170	COG0534	Mate efflux family protein
EXW40_06175	COG4166	transmembrane transport
EXW40_06195	COG0861	Integral membrane protein TerC family
EXW40_06200	COG4862	establishment of competence for transformation
EXW40_06205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW40_06215	COG1164	Oligoendopeptidase f
EXW40_06225	COG2346	COG2346, Truncated hemoglobins
EXW40_06230	COG4116	CYTH
EXW40_06240	COG2357	RelA SpoT domain protein
EXW40_06250	COG0564	pseudouridine synthase activity
EXW40_06260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW40_06265	COG0772	Belongs to the SEDS family
EXW40_06270	COG1216	Glycosyl transferase, family 2
EXW40_06290	COG0457	Tetratricopeptide repeat
EXW40_06290	COG0463	Glycosyl transferase, family 2
EXW40_06310	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW40_06325	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW40_06370	COG2153	protein acetylation
EXW40_06375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW40_06380	COG2382	esterase
EXW40_06405	COG5492	domain, Protein
EXW40_06410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW40_06430	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW40_06430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW40_06435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW40_06440	COG0134	indole-3-glycerol-phosphate synthase activity
EXW40_06445	COG0135	phosphoribosylanthranilate isomerase activity
EXW40_06450	COG0133	tryptophan synthase activity
EXW40_06455	COG0159	tryptophan synthase activity
EXW40_06465	COG1620	l-lactate permease
EXW40_06470	COG5634	Uncharacterized conserved protein (DUF2278)
EXW40_06510	COG2226	methyltransferase
EXW40_06530	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW40_06535	COG0567	Dehydrogenase, E1 component
EXW40_06540	COG1476	TRANSCRIPTIONal
EXW40_06565	COG4152	abc transporter atp-binding protein
EXW40_06570	COG1668	transmembrane transport
EXW40_06590	COG1686	Belongs to the peptidase S11 family
EXW40_06595	COG0681	Belongs to the peptidase S26 family
EXW40_06630	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_06640	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW40_06645	COG1177	transmembrane transport
EXW40_06650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW40_06660	COG2409	Drug exporters of the RND superfamily
EXW40_06670	COG0564	pseudouridine synthase activity
EXW40_06680	COG2340	Cysteine-rich secretory protein family
EXW40_06685	COG0247	lactate metabolic process
EXW40_06690	COG0277	FAD linked oxidase domain protein
EXW40_06695	COG3835	regulator
EXW40_06705	COG0745	RESPONSE REGULATOR receiver
EXW40_06710	COG3850	Histidine kinase
EXW40_06710	COG5002	protein histidine kinase activity
EXW40_06715	COG2186	Transcriptional regulator
EXW40_06720	COG0247	lactate metabolic process
EXW40_06725	COG1139	Iron-sulfur cluster binding protein
EXW40_06730	COG1556	Lactate utilization protein
EXW40_06735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW40_06745	COG2116	formate transmembrane transporter activity
EXW40_06750	COG0861	Integral membrane protein TerC family
EXW40_06755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW40_06765	COG2030	dehydratase
EXW40_06785	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_06790	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW40_06800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW40_06815	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW40_06820	COG3842	ATPase activity
EXW40_06830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW40_06835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW40_06845	COG1349	DNA-binding transcription factor activity
EXW40_06855	COG0235	Class ii aldolase
EXW40_06865	COG2861	carbohydrate metabolic process
EXW40_06875	COG3852	Histidine kinase
EXW40_06880	COG1846	Transcriptional regulator
EXW40_06890	COG2318	DinB family
EXW40_06895	COG5002	protein histidine kinase activity
EXW40_06900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW40_06905	COG0720	synthase
EXW40_06915	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW40_06920	COG4873	Protein conserved in bacteria
EXW40_06930	COG0456	acetyltransferase
EXW40_06950	COG1780	Probably involved in ribonucleotide reductase function
EXW40_06965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW40_06970	COG0531	amino acid
EXW40_06975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW40_06990	COG2204	response regulator
EXW40_06995	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_07005	COG1725	Transcriptional regulator
EXW40_07010	COG1131	(ABC) transporter
EXW40_07020	COG1131	(ABC) transporter
EXW40_07025	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW40_07040	COG1522	sequence-specific DNA binding
EXW40_07050	COG1335	isochorismatase
EXW40_07060	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW40_07065	COG2070	2-Nitropropane dioxygenase
EXW40_07070	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW40_07075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW40_07080	COG1696	Membrane protein involved in D-alanine export
EXW40_07085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW40_07100	COG0716	FMN binding
EXW40_07125	COG0534	Mate efflux family protein
EXW40_07145	COG1846	Transcriptional regulator
EXW40_07160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW40_07170	COG3874	Sporulation protein YtfJ
EXW40_07190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW40_07195	COG0028	Belongs to the TPP enzyme family
EXW40_07200	COG0440	acetolactate synthase activity
EXW40_07210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW40_07220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW40_07230	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW40_07235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW40_07245	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW40_07250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW40_07255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW40_07260	COG0107	imidazoleglycerol-phosphate synthase activity
EXW40_07270	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW40_07275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW40_07290	COG1183	phosphatidylcholine synthase activity
EXW40_07295	COG1368	sulfuric ester hydrolase activity
EXW40_07305	COG0019	diaminopimelate decarboxylase activity
EXW40_07315	COG0175	sulfate reduction
EXW40_07320	COG2046	Belongs to the sulfate adenylyltransferase family
EXW40_07325	COG0529	Catalyzes the synthesis of activated sulfate
EXW40_07330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW40_07350	COG1648	precorrin-2 dehydrogenase activity
EXW40_07355	COG0733	neurotransmitter:sodium symporter activity
EXW40_07375	COG1757	Na H antiporter
EXW40_07395	COG4758	membrane
EXW40_07400	COG4585	Histidine kinase
EXW40_07405	COG2197	response regulator
EXW40_07415	COG1114	Component of the transport system for branched-chain amino acids
EXW40_07425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW40_07470	COG0730	response to heat
EXW40_07475	COG0306	phosphate transporter
EXW40_07480	COG1392	Phosphate transport regulator
EXW40_07485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW40_07500	COG3852	Histidine kinase
EXW40_07505	COG1801	Protein of unknown function DUF72
EXW40_07515	COG0582	viral genome integration into host DNA
EXW40_07520	COG5002	protein histidine kinase activity
EXW40_07535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW40_07535	COG0392	lysyltransferase activity
EXW40_07550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW40_07555	COG1686	Belongs to the peptidase S11 family
EXW40_07560	COG2715	membrane protein required for spore maturation
EXW40_07565	COG0700	Nucleoside recognition
EXW40_07570	COG1187	pseudouridine synthase activity
EXW40_07580	COG1333	cytochrome c biogenesis protein
EXW40_07585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW40_07590	COG0745	RESPONSE REGULATOR receiver
EXW40_07595	COG5002	protein histidine kinase activity
EXW40_07600	COG2096	Adenosyltransferase
EXW40_07605	COG4942	peptidase
EXW40_07615	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW40_07620	COG1141	Ferredoxin
EXW40_07630	COG4955	Helix-turn-helix domain
EXW40_07635	COG0514	ATP-dependent DNA helicase (RecQ)
EXW40_07640	COG1266	CAAX protease self-immunity
EXW40_07650	COG1408	metallophosphoesterase
EXW40_07665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW40_07685	COG0492	ferredoxin-NADP+ reductase activity
EXW40_07690	COG0252	asparaginase activity
EXW40_07695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW40_07705	COG1304	FMN binding
EXW40_07735	COG1160	GTP binding
EXW40_07740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW40_07760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW40_07770	COG0302	gtp cyclohydrolase
EXW40_07775	COG0142	geranyltranstransferase activity
EXW40_07780	COG2226	methyltransferase
EXW40_07785	COG0142	geranyltranstransferase activity
EXW40_07800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW40_07810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW40_07815	COG0457	Tetratricopeptide repeat
EXW40_07820	COG5582	Belongs to the UPF0302 family
EXW40_07835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW40_07850	COG4347	Protein of unknown function (DUF1405)
EXW40_07865	COG2738	Putative neutral zinc metallopeptidase
EXW40_07875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW40_07885	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW40_07890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW40_07895	COG1803	Methylglyoxal synthase
EXW40_07900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW40_07905	COG0438	transferase activity, transferring glycosyl groups
EXW40_07910	COG0617	tRNA 3'-terminal CCA addition
EXW40_07920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW40_07925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW40_07935	COG1199	ATP-dependent helicase activity
EXW40_07935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW40_07955	COG3935	DnaD domain protein
EXW40_07960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW40_07970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW40_07970	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW40_07975	COG3331	DNA recombination
EXW40_08010	COG4474	Belongs to the UPF0398 family
EXW40_08015	COG3599	regulation of cell shape
EXW40_08025	COG0116	Belongs to the methyltransferase superfamily
EXW40_08035	COG1199	ATP-dependent helicase activity
EXW40_08040	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW40_08050	COG0024	Methionine aminopeptidase
EXW40_08060	COG2233	PERMEase
EXW40_08065	COG2311	Membrane
EXW40_08070	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW40_08080	COG0456	acetyltransferase
EXW40_08090	COG2897	thiosulfate sulfurtransferase activity
EXW40_08130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW40_08155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW40_08170	COG1215	transferase activity, transferring glycosyl groups
EXW40_08175	COG0438	transferase activity, transferring glycosyl groups
EXW40_08190	COG0454	-acetyltransferase
EXW40_08210	COG0328	RNA-DNA hybrid ribonuclease activity
EXW40_08245	COG3403	YqcI/YcgG family
EXW40_08250	COG1280	lysine exporter protein (LysE YggA)
EXW40_08265	COG3162	membrane
EXW40_08275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW40_08285	COG0475	glutathione-regulated potassium exporter activity
EXW40_08290	COG4978	Transcriptional regulator
EXW40_08290	COG0789	Transcriptional regulator
EXW40_08300	COG2323	membrane
EXW40_08305	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW40_08350	COG1923	regulation of RNA biosynthetic process
EXW40_08360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW40_08365	COG1360	Flagellar Motor Protein
EXW40_08370	COG2201	protein-glutamate methylesterase activity
EXW40_08375	COG0643	Histidine kinase
EXW40_08375	COG2198	Histidine kinase
EXW40_08380	COG1776	CheC inhibitor of MCP methylation
EXW40_08380	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW40_08395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW40_08415	COG1256	bacterial-type flagellum assembly
EXW40_08420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW40_08445	COG1815	bacterial-type flagellum-dependent cell motility
EXW40_08450	COG1558	bacterial-type flagellum-dependent cell motility
EXW40_08460	COG1766	The M ring may be actively involved in energy transduction
EXW40_08465	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW40_08475	COG1157	protein secretion by the type III secretion system
EXW40_08495	COG1749	Flagellar hook protein flgE
EXW40_08510	COG0784	Response regulator, receiver
EXW40_08510	COG0835	chemotaxis
EXW40_08535	COG0861	Integral membrane protein TerC family
EXW40_08545	COG3383	formate dehydrogenase (NAD+) activity
EXW40_08550	COG2427	Protein of unknown function (DUF1641)
EXW40_08555	COG5609	conserved protein (DUF2294)
EXW40_08560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW40_08570	COG2116	formate transmembrane transporter activity
EXW40_08575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW40_08580	COG0303	'Molybdopterin
EXW40_08585	COG0314	molybdopterin synthase activity
EXW40_08590	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXW40_08600	COG0489	protein tyrosine kinase activity
EXW40_08605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW40_08610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW40_08615	COG0741	lytic transglycosylase activity
EXW40_08625	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW40_08630	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW40_08630	COG1776	CheC inhibitor of MCP methylation
EXW40_08640	COG1338	Plays a role in the flagellum-specific transport system
EXW40_08645	COG1987	bacterial-type flagellum assembly
EXW40_08655	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW40_08660	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW40_08665	COG1419	protein localization to endoplasmic reticulum
EXW40_08670	COG4786	Flagellar basal body rod
EXW40_08675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW40_08715	COG2329	Antibiotic biosynthesis monooxygenase
EXW40_08730	COG2814	Major facilitator Superfamily
EXW40_08740	COG0583	DNA-binding transcription factor activity
EXW40_08745	COG3842	ATPase activity
EXW40_08795	COG0406	alpha-ribazole phosphatase activity
EXW40_08825	COG0367	asparagine synthase
EXW40_08855	COG1802	Transcriptional regulator
EXW40_08860	COG0697	spore germination
EXW40_08875	COG0438	transferase activity, transferring glycosyl groups
EXW40_08875	COG1216	Glycosyl transferase, family 2
EXW40_08880	COG1757	Na H antiporter
EXW40_08900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW40_08920	COG0534	Mate efflux family protein
EXW40_08925	COG3340	Belongs to the peptidase S51 family
EXW40_08945	COG0785	Cytochrome C biogenesis protein
EXW40_08950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW40_08965	COG3048	D-serine ammonia-lyase activity
EXW40_08970	COG2733	membrane
EXW40_09010	COG1131	(ABC) transporter
EXW40_09025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW40_09030	COG0528	UMP kinase activity
EXW40_09040	COG1027	Aspartate ammonia-lyase
EXW40_09045	COG0281	malic enzyme
EXW40_09050	COG4191	Histidine kinase
EXW40_09055	COG0784	Response regulator, receiver
EXW40_09060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW40_09075	COG2502	aspartate--ammonia ligase
EXW40_09080	COG3620	sequence-specific DNA binding
EXW40_09115	COG1051	belongs to the nudix hydrolase family
EXW40_09120	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW40_09130	COG2814	Major facilitator Superfamily
EXW40_09155	COG1695	Transcriptional regulator
EXW40_09170	COG0477	Major facilitator Superfamily
EXW40_09185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW40_09190	COG2223	nitrite transmembrane transporter activity
EXW40_09195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW40_09210	COG2244	polysaccharide biosynthetic process
EXW40_09215	COG0733	neurotransmitter:sodium symporter activity
EXW40_09225	COG5566	PFAM Mor transcription activator
EXW40_09230	COG2323	membrane
EXW40_09250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW40_09255	COG2132	Multicopper oxidase
EXW40_09265	COG5002	protein histidine kinase activity
EXW40_09270	COG0745	RESPONSE REGULATOR receiver
EXW40_09280	COG0129	dihydroxy-acid dehydratase activity
EXW40_09285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW40_09310	COG2814	Major facilitator Superfamily
EXW40_09315	COG3384	dioxygenase
EXW40_09355	COG4166	transmembrane transport
EXW40_09360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW40_09380	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW40_09385	COG1054	Belongs to the UPF0176 family
EXW40_09395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW40_09400	COG0531	amino acid
EXW40_09425	COG2390	Transcriptional regulator
EXW40_09435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW40_09440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW40_09445	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW40_09450	COG0295	cytidine deaminase activity
EXW40_09460	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW40_09480	COG0583	DNA-binding transcription factor activity
EXW40_09500	COG0006	proline dipeptidase activity
EXW40_09505	COG2132	Multicopper oxidase
EXW40_09515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW40_09525	COG0583	DNA-binding transcription factor activity
EXW40_09545	COG1114	Component of the transport system for branched-chain amino acids
EXW40_09555	COG1834	amidinotransferase
EXW40_09565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW40_09575	COG1276	copper resistance
EXW40_09575	COG2372	response to copper ion
EXW40_09580	COG4549	nuclear export factor GLE1
EXW40_09590	COG0697	spore germination
EXW40_09595	COG0583	DNA-binding transcription factor activity
EXW40_09600	COG1959	2 iron, 2 sulfur cluster binding
EXW40_09605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW40_09610	COG0778	Nitroreductase
EXW40_09620	COG0628	permease
EXW40_09635	COG1231	oxidoreductase activity
EXW40_09640	COG0523	cobalamin synthesis protein
EXW40_09650	COG0411	ABC transporter
EXW40_09670	COG0583	DNA-binding transcription factor activity
EXW40_09680	COG1942	4-Oxalocrotonate Tautomerase
EXW40_09695	COG0346	lactoylglutathione lyase activity
EXW40_09705	COG1271	oxidase subunit
EXW40_09710	COG1294	oxidase, subunit
EXW40_09715	COG4988	ABC transporter
EXW40_09720	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW40_09750	COG1686	Belongs to the peptidase S11 family
EXW40_09765	COG0791	NLP P60 protein
EXW40_09765	COG1388	LysM domain
EXW40_09775	COG1132	(ABC) transporter
EXW40_09780	COG0745	RESPONSE REGULATOR receiver
EXW40_09785	COG5002	protein histidine kinase activity
EXW40_09790	COG0300	oxidoreductase activity
EXW40_09795	COG4122	O-methyltransferase activity
EXW40_09825	COG0460	homoserine dehydrogenase
EXW40_09835	COG0083	homoserine kinase activity
EXW40_09850	COG1316	TRANSCRIPTIONal
EXW40_09865	COG1285	pathogenesis
EXW40_09870	COG1247	-acetyltransferase
EXW40_09890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW40_09900	COG1082	Xylose isomerase domain protein TIM barrel
EXW40_09910	COG2814	Major facilitator Superfamily
EXW40_09915	COG1279	arginine transmembrane transporter activity
EXW40_09920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW40_09930	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW40_09960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW40_09965	COG0577	efflux transmembrane transporter activity
EXW40_09970	COG2002	toxin-antitoxin pair type II binding
EXW40_09975	COG1404	Belongs to the peptidase S8 family
EXW40_09980	COG0640	Transcriptional regulator
EXW40_09985	COG0667	Aldo Keto reductase
EXW40_09990	COG2814	Major facilitator Superfamily
EXW40_10030	COG3949	Membrane
EXW40_10035	COG0783	Belongs to the Dps family
EXW40_10050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW40_10060	COG1231	oxidoreductase activity
EXW40_10065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW40_10070	COG4989	oxidoreductase activity
EXW40_10075	COG0523	cobalamin synthesis protein
EXW40_10080	COG0456	acetyltransferase
EXW40_10085	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW40_10110	COG1136	(ABC) transporter
EXW40_10115	COG0577	efflux transmembrane transporter activity
EXW40_10120	COG0745	RESPONSE REGULATOR receiver
EXW40_10125	COG2205	protein histidine kinase activity
EXW40_10130	COG1902	pentaerythritol trinitrate reductase activity
EXW40_10135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW40_10145	COG4166	transmembrane transport
EXW40_10150	COG0346	lactoylglutathione lyase activity
EXW40_10160	COG0406	alpha-ribazole phosphatase activity
EXW40_10170	COG5337	Spore coat protein CotH
EXW40_10175	COG1051	belongs to the nudix hydrolase family
EXW40_10180	COG0586	Pfam SNARE associated Golgi protein
EXW40_10185	COG2244	polysaccharide biosynthetic process
EXW40_10195	COG0701	Predicted permease
EXW40_10200	COG3689	TIGRFAM TIGR03943 family protein
EXW40_10205	COG1607	acyl-coa hydrolase
EXW40_10215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW40_10230	COG0702	epimerase
EXW40_10235	COG2839	Protein conserved in bacteria
EXW40_10240	COG1253	flavin adenine dinucleotide binding
EXW40_10265	COG1114	Component of the transport system for branched-chain amino acids
EXW40_10270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW40_10290	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW40_10305	COG1876	peptidase activity
EXW40_10310	COG0494	nUDIX hydrolase
EXW40_10335	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW40_10345	COG0561	phosphatase activity
EXW40_10350	COG1846	Transcriptional regulator
EXW40_10355	COG2814	Major facilitator Superfamily
EXW40_10365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW40_10370	COG4106	trans-aconitate 2-methyltransferase activity
EXW40_10385	COG1819	glycosyl
EXW40_10390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW40_10395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW40_10420	COG0456	acetyltransferase
EXW40_10465	COG4974	Belongs to the 'phage' integrase family
EXW40_10565	COG3874	Sporulation protein YtfJ
EXW40_10590	COG2226	methyltransferase
EXW40_10620	COG0604	alcohol dehydrogenase
EXW40_10625	COG1595	DNA-templated transcription, initiation
EXW40_10650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW40_10650	COG0426	domain, Protein
EXW40_10660	COG0386	Belongs to the glutathione peroxidase family
EXW40_10665	COG1305	Transglutaminase-like
EXW40_10670	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW40_10675	COG0714	Associated with various cellular activities
EXW40_10680	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW40_10685	COG1140	nitrate reductase beta subunit
EXW40_10690	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW40_10695	COG2181	nitrate reductase activity
EXW40_10700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW40_10705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW40_10710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW40_10715	COG0303	'Molybdopterin
EXW40_10720	COG0314	molybdopterin synthase activity
EXW40_10730	COG2223	nitrite transmembrane transporter activity
EXW40_10750	COG1648	precorrin-2 dehydrogenase activity
EXW40_10760	COG1587	Uroporphyrinogen-III synthase
EXW40_10760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW40_10765	COG2146	nitrite reductase [NAD(P)H] activity
EXW40_10770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW40_10775	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW40_10805	COG2359	stage V sporulation protein S
EXW40_10815	COG1418	mRNA catabolic process
EXW40_10820	COG0488	(ABC) transporter
EXW40_10850	COG1413	lyase activity
EXW40_10865	COG2521	methyltransferase
EXW40_10865	COG2136	Putative SAM-dependent methyltransferase
EXW40_10870	COG0018	arginyl-trna synthetase
EXW40_10920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW40_10930	COG0017	Asparaginyl-tRNA synthetase
EXW40_10935	COG0733	neurotransmitter:sodium symporter activity
EXW40_10965	COG2610	gluconate transmembrane transporter activity
EXW40_10975	COG1794	racemase activity, acting on amino acids and derivatives
EXW40_10985	COG0456	acetyltransferase
EXW40_10990	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW40_10995	COG1131	(ABC) transporter
EXW40_11000	COG4473	ABC transporter
EXW40_11010	COG0546	phosphoglycolate phosphatase activity
EXW40_11060	COG0768	penicillin binding
EXW40_11075	COG1272	protein, Hemolysin III
EXW40_11080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW40_11085	COG0805	protein transport
EXW40_11095	COG1307	EDD domain protein, DegV family
EXW40_11100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW40_11105	COG1999	signal sequence binding
EXW40_11110	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW40_11115	COG0367	asparagine synthase
EXW40_11130	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW40_11135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW40_11140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW40_11160	COG1335	isochorismatase
EXW40_11170	COG0668	transmembrane transport
EXW40_11175	COG2203	Gaf domain
EXW40_11175	COG4585	Histidine kinase
EXW40_11180	COG2197	response regulator
EXW40_11185	COG1737	Transcriptional regulator
EXW40_11190	COG1064	alcohol dehydrogenase
EXW40_11210	COG1070	Carbohydrate kinase
EXW40_11220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW40_11240	COG0517	IMP dehydrogenase activity
EXW40_11240	COG1125	glycine betaine transport
EXW40_11245	COG1174	glycine betaine transport
EXW40_11280	COG1253	flavin adenine dinucleotide binding
EXW40_11285	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_11290	COG5506	Protein of unknown function (DUF1694)
EXW40_11305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW40_11310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW40_11315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW40_11320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW40_11325	COG0456	acetyltransferase
EXW40_11330	COG3829	transcription factor binding
EXW40_11335	COG1509	lysine 2,3-aminomutase activity
EXW40_11345	COG4479	Belongs to the UPF0346 family
EXW40_11370	COG3064	Membrane
EXW40_11370	COG0515	serine threonine protein kinase
EXW40_11370	COG4991	sh3 domain protein
EXW40_11380	COG0671	phosphoesterase, PA-phosphatase related
EXW40_11385	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW40_11390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW40_11465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW40_11490	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_11510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW40_11510	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW40_11520	COG2814	Major facilitator Superfamily
EXW40_11530	COG0372	Belongs to the citrate synthase family
EXW40_11535	COG2079	MmgE PrpD family protein
EXW40_11540	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW40_11545	COG1960	acyl-CoA dehydrogenase activity
EXW40_11550	COG2084	Dehydrogenase
EXW40_11555	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_11560	COG1280	lysine exporter protein (LysE YggA)
EXW40_11565	COG1024	Enoyl-CoA hydratase
EXW40_11580	COG0420	3'-5' exonuclease activity
EXW40_11600	COG2223	nitrite transmembrane transporter activity
EXW40_11605	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_11610	COG1169	isochorismate synthase
EXW40_11615	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW40_11620	COG1535	isochorismatase
EXW40_11620	COG3433	isochorismatase activity
EXW40_11625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW40_11630	COG3251	PFAM MbtH domain protein
EXW40_11635	COG2814	Major facilitator Superfamily
EXW40_11650	COG0776	regulation of translation
EXW40_11660	COG2318	DinB family
EXW40_11665	COG1115	amino acid carrier protein
EXW40_11680	COG2329	Antibiotic biosynthesis monooxygenase
EXW40_11695	COG1187	pseudouridine synthase activity
EXW40_11700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW40_11705	COG3655	Transcriptional regulator
EXW40_11715	COG1136	(ABC) transporter
EXW40_11725	COG2814	Major facilitator Superfamily
EXW40_11740	COG0028	Belongs to the TPP enzyme family
EXW40_11765	COG1253	flavin adenine dinucleotide binding
EXW40_11800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW40_11820	COG1846	Transcriptional regulator
EXW40_11835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW40_11840	COG1309	transcriptional regulator
EXW40_11870	COG1247	-acetyltransferase
EXW40_11890	COG1132	(ABC) transporter
EXW40_11900	COG1309	transcriptional regulator
EXW40_11905	COG2357	RelA SpoT domain protein
EXW40_11910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW40_11915	COG1819	glycosyl
EXW40_11945	COG0596	Alpha beta hydrolase
EXW40_11950	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW40_11960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW40_11990	COG0583	DNA-binding transcription factor activity
EXW40_11995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW40_12055	COG0583	DNA-binding transcription factor activity
EXW40_12060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW40_12065	COG2258	MOSC domain
EXW40_12080	COG1132	(ABC) transporter
EXW40_12085	COG1132	(ABC) transporter
EXW40_12095	COG1396	sequence-specific DNA binding
EXW40_12120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW40_12130	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW40_12135	COG1595	DNA-templated transcription, initiation
EXW40_12155	COG1649	PFAM Uncharacterised BCR, COG1649
EXW40_12175	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW40_12180	COG2971	BadF BadG BcrA BcrD
EXW40_12245	COG1309	transcriptional regulator
EXW40_12260	COG0577	efflux transmembrane transporter activity
EXW40_12260	COG1136	(ABC) transporter
EXW40_12265	COG3615	Tellurite resistance protein tehB
EXW40_12265	COG0500	methyltransferase
EXW40_12280	COG0588	phosphoglycerate mutase activity
EXW40_12300	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW40_12305	COG0110	maltose O-acetyltransferase activity
EXW40_12320	COG1136	(ABC) transporter
EXW40_12350	COG1686	Belongs to the peptidase S11 family
EXW40_12375	COG0768	penicillin binding
EXW40_12380	COG0745	RESPONSE REGULATOR receiver
EXW40_12385	COG2205	protein histidine kinase activity
EXW40_12390	COG1136	(ABC) transporter
EXW40_12395	COG0577	efflux transmembrane transporter activity
EXW40_12405	COG1595	DNA-templated transcription, initiation
EXW40_12415	COG0768	penicillin binding
EXW40_12420	COG0768	penicillin binding
EXW40_12455	COG1252	NADH dehydrogenase
EXW40_12460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW40_12460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW40_12475	COG0697	spore germination
EXW40_12505	COG3397	chitin binding
EXW40_12510	COG0823	Involved in the tonB-independent uptake of proteins
EXW40_12520	COG1408	metallophosphoesterase
EXW40_12530	COG1131	(ABC) transporter
EXW40_12540	COG1309	transcriptional regulator
EXW40_12550	COG1960	acyl-CoA dehydrogenase activity
EXW40_12555	COG0439	Biotin carboxylase
EXW40_12560	COG0511	ligase activity, forming carbon-carbon bonds
EXW40_12565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW40_12570	COG1024	Enoyl-CoA hydratase
EXW40_12575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW40_12580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW40_12620	COG0572	uridine kinase
EXW40_12655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW40_12685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW40_12710	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_12715	COG1733	regulation of RNA biosynthetic process
EXW40_12740	COG1309	transcriptional regulator
EXW40_12770	COG0697	spore germination
EXW40_12775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW40_12805	COG2323	membrane
EXW40_12810	COG2132	Multicopper oxidase
EXW40_12825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW40_12830	COG0697	spore germination
EXW40_12835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW40_12840	COG0201	protein transport
EXW40_12850	COG0737	Belongs to the 5'-nucleotidase family
EXW40_12855	COG3227	Zinc metalloprotease (Elastase)
EXW40_12860	COG1523	belongs to the glycosyl hydrolase 13 family
EXW40_12875	COG0076	glutamate decarboxylase activity
EXW40_12880	COG0657	acetylesterase activity
EXW40_12890	COG1073	alpha beta
EXW40_12900	COG0577	efflux transmembrane transporter activity
EXW40_12905	COG1136	(ABC) transporter
EXW40_12920	COG5002	protein histidine kinase activity
EXW40_12925	COG0745	RESPONSE REGULATOR receiver
EXW40_12930	COG1011	Hydrolase
EXW40_12955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW40_12960	COG1183	phosphatidylcholine synthase activity
EXW40_12970	COG1132	(ABC) transporter
EXW40_12975	COG3961	Belongs to the TPP enzyme family
EXW40_12995	COG0322	excinuclease ABC activity
EXW40_13020	COG2318	DinB family
EXW40_13035	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW40_13090	COG0592	DNA-directed DNA polymerase activity
EXW40_13095	COG2816	NAD+ diphosphatase activity
EXW40_13105	COG2223	nitrite transmembrane transporter activity
EXW40_13110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW40_13120	COG0494	nUDIX hydrolase
EXW40_13140	COG0697	spore germination
EXW40_13145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW40_13155	COG0584	glycerophosphoryl diester phosphodiesterase
EXW40_13170	COG1733	regulation of RNA biosynthetic process
EXW40_13180	COG2814	Major facilitator Superfamily
EXW40_13195	COG2375	cellular response to nickel ion
EXW40_13195	COG1132	(ABC) transporter
EXW40_13200	COG1132	(ABC) transporter
EXW40_13235	COG0768	penicillin binding
EXW40_13240	COG0671	phosphoesterase, PA-phosphatase related
EXW40_13245	COG0604	alcohol dehydrogenase
EXW40_13250	COG5002	protein histidine kinase activity
EXW40_13255	COG0745	RESPONSE REGULATOR receiver
EXW40_13265	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW40_13275	COG2205	protein histidine kinase activity
EXW40_13290	COG1122	ATPase activity
EXW40_13295	COG4720	Psort location CytoplasmicMembrane, score
EXW40_13300	COG1794	racemase activity, acting on amino acids and derivatives
EXW40_13305	COG1819	glycosyl
EXW40_13315	COG0768	penicillin binding
EXW40_13320	COG5002	protein histidine kinase activity
EXW40_13325	COG0561	phosphatase activity
EXW40_13375	COG2124	cytochrome p450
EXW40_13425	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW40_13435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW40_13440	COG0460	homoserine dehydrogenase
EXW40_13460	COG0577	efflux transmembrane transporter activity
EXW40_13465	COG1136	(ABC) transporter
EXW40_13480	COG0488	(ABC) transporter
EXW40_13485	COG0667	Aldo Keto reductase
EXW40_13490	COG0583	DNA-binding transcription factor activity
EXW40_13515	COG2205	protein histidine kinase activity
EXW40_13520	COG0745	RESPONSE REGULATOR receiver
EXW40_13530	COG3773	Cell wall hydrolase
EXW40_13535	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW40_13545	COG3386	PFAM SMP-30 Gluconolaconase
EXW40_13555	COG0604	alcohol dehydrogenase
EXW40_13615	COG2959	enzyme of heme biosynthesis
EXW40_13645	COG3483	tryptophan 2,3-dioxygenase activity
EXW40_13650	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW40_13655	COG3844	kynureninase activity
EXW40_13660	COG1309	transcriptional regulator
EXW40_13675	COG3284	Transcriptional regulator
EXW40_13690	COG1349	DNA-binding transcription factor activity
EXW40_13715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW40_13720	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW40_13725	COG0022	dehydrogenase e1 component
EXW40_13730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW40_13740	COG2223	nitrite transmembrane transporter activity
EXW40_13750	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_13755	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW40_13755	COG0456	acetyltransferase
EXW40_13790	COG4176	ABC-type proline glycine betaine transport system permease component
EXW40_13795	COG0517	IMP dehydrogenase activity
EXW40_13795	COG4175	Glycine betaine
EXW40_13820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW40_13825	COG2153	protein acetylation
EXW40_13830	COG3397	chitin binding
EXW40_13840	COG1819	glycosyl
EXW40_13855	COG2205	protein histidine kinase activity
EXW40_13860	COG2315	Protein conserved in bacteria
EXW40_13905	COG3973	AAA domain
EXW40_13915	COG2105	PFAM AIG2 family protein
EXW40_13920	COG0514	ATP-dependent DNA helicase (RecQ)
EXW40_13940	COG4637	Psort location Cytoplasmic, score
EXW40_13950	COG1227	inorganic diphosphatase activity
EXW40_13955	COG3397	chitin binding
EXW40_13965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW40_13970	COG1115	amino acid carrier protein
EXW40_13975	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_13980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW40_13990	COG3938	Belongs to the proline racemase family
EXW40_13995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW40_14035	COG0586	Pfam SNARE associated Golgi protein
EXW40_14050	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW40_14055	COG4166	transmembrane transport
EXW40_14065	COG4948	Mandelate Racemase Muconate Lactonizing
EXW40_14085	COG0667	Aldo Keto reductase
EXW40_14130	COG2936	dipeptidyl-peptidase activity
EXW40_14140	COG0745	RESPONSE REGULATOR receiver
EXW40_14160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW40_14165	COG1164	Oligoendopeptidase f
EXW40_14170	COG0531	amino acid
EXW40_14175	COG1522	sequence-specific DNA binding
EXW40_14195	COG1307	EDD domain protein, DegV family
EXW40_14230	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXW40_14255	COG2814	Major facilitator Superfamily
EXW40_14265	COG1664	Polymer-forming cytoskeletal
EXW40_14270	COG0789	Transcriptional regulator
EXW40_14275	COG4533	DNA binding
EXW40_14280	COG0477	Major facilitator Superfamily
EXW40_14280	COG2814	Major facilitator Superfamily
EXW40_14300	COG2261	transglycosylase associated protein
EXW40_14315	COG2226	methyltransferase
EXW40_14350	COG0436	Aminotransferase
EXW40_14355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW40_14380	COG1131	(ABC) transporter
EXW40_14385	COG2188	Transcriptional regulator
EXW40_14425	COG0628	permease
EXW40_14435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW40_14465	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW40_14475	COG0697	spore germination
EXW40_14480	COG2318	DinB family
EXW40_14530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW40_14540	COG2814	Major facilitator Superfamily
EXW40_14545	COG1368	sulfuric ester hydrolase activity
EXW40_14560	COG0488	(ABC) transporter
EXW40_14565	COG2409	Drug exporters of the RND superfamily
EXW40_14565	COG1033	growth of symbiont in host cell
EXW40_14575	COG1309	transcriptional regulator
EXW40_14595	COG0287	Prephenate dehydrogenase
EXW40_14610	COG1605	Chorismate mutase
EXW40_14610	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW40_14640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EXW40_14665	COG0346	lactoylglutathione lyase activity
EXW40_14675	COG0431	NADPH-dependent FMN reductase
EXW40_14705	COG0579	oxidoreductase
EXW40_14710	COG1879	ABC-type sugar transport system periplasmic component
EXW40_14720	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW40_14725	COG1129	ABC transporter
EXW40_14730	COG2390	Transcriptional regulator
EXW40_14750	COG2226	methyltransferase
EXW40_14765	COG0346	lactoylglutathione lyase activity
EXW40_14770	COG2329	Antibiotic biosynthesis monooxygenase
EXW40_14790	COG1472	Belongs to the glycosyl hydrolase 3 family
EXW40_14795	COG2207	Transcriptional regulator
EXW40_14805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW40_14810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW40_14815	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW40_14820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW40_14825	COG3239	Fatty acid desaturase
EXW40_14845	COG3655	Transcriptional regulator
EXW40_14890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW40_14895	COG0346	lactoylglutathione lyase activity
EXW40_14920	COG0714	Associated with various cellular activities
EXW40_14940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW40_14945	COG0753	catalase activity
EXW40_14965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW40_14985	COG0778	Nitroreductase
EXW40_14990	COG1846	Transcriptional regulator
EXW40_15010	COG1051	belongs to the nudix hydrolase family
EXW40_15015	COG4884	unkown
EXW40_15015	COG3831	ATPase activity
EXW40_15035	COG2207	Transcriptional regulator
EXW40_15040	COG0456	acetyltransferase
EXW40_15055	COG0697	spore germination
EXW40_15060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW40_15070	COG1671	Belongs to the UPF0178 family
EXW40_15085	COG0745	RESPONSE REGULATOR receiver
EXW40_15090	COG0596	Alpha beta hydrolase
EXW40_15100	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW40_15100	COG0456	acetyltransferase
EXW40_15125	COG0730	response to heat
EXW40_15135	COG0833	amino acid
EXW40_15145	COG4335	DNA alkylation repair
EXW40_15175	COG0681	Belongs to the peptidase S26 family
EXW40_15180	COG0768	penicillin binding
EXW40_15190	COG3104	oligopeptide transport
EXW40_15195	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW40_15210	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW40_15215	COG1984	allophanate hydrolase subunit 2
EXW40_15220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW40_15225	COG1414	Transcriptional regulator
EXW40_15255	COG1960	acyl-CoA dehydrogenase activity
EXW40_15270	COG0346	lactoylglutathione lyase activity
EXW40_15280	COG0640	Transcriptional regulator
EXW40_15290	COG3314	Sporulation integral membrane protein YlbJ
EXW40_15310	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW40_15325	COG3848	Pyruvate phosphate dikinase
EXW40_15325	COG0574	Belongs to the PEP-utilizing enzyme family
EXW40_15335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW40_15340	COG1876	peptidase activity
EXW40_15350	COG5002	protein histidine kinase activity
EXW40_15355	COG0745	RESPONSE REGULATOR receiver
EXW40_15360	COG4990	cell redox homeostasis
EXW40_15385	COG5002	protein histidine kinase activity
EXW40_15390	COG0745	RESPONSE REGULATOR receiver
EXW40_15400	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW40_15415	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW40_15420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW40_15425	COG1121	(ABC) transporter
EXW40_15450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW40_15450	COG3320	Male sterility
EXW40_15455	COG1309	transcriptional regulator
EXW40_15460	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_15465	COG1522	sequence-specific DNA binding
EXW40_15480	COG0346	lactoylglutathione lyase activity
EXW40_15510	COG2226	methyltransferase
EXW40_15520	COG2814	Major facilitator Superfamily
EXW40_15550	COG0745	RESPONSE REGULATOR receiver
EXW40_15555	COG5002	protein histidine kinase activity
EXW40_15555	COG3850	Histidine kinase
EXW40_15585	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW40_15600	COG2309	aminopeptidase activity
EXW40_15610	COG1690	Belongs to the RtcB family
EXW40_15620	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW40_15640	COG1136	(ABC) transporter
EXW40_15645	COG0577	efflux transmembrane transporter activity
EXW40_15665	COG3850	Histidine kinase
EXW40_15665	COG5002	protein histidine kinase activity
EXW40_15680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW40_15700	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW40_15720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW40_15750	COG5444	nuclease activity
EXW40_15800	COG2814	Major facilitator Superfamily
EXW40_15835	COG0477	Major facilitator Superfamily
EXW40_15850	COG1846	Transcriptional regulator
EXW40_15855	COG2814	Major facilitator Superfamily
EXW40_15900	COG0789	Transcriptional regulator
EXW40_15935	COG1476	TRANSCRIPTIONal
EXW40_15950	COG1288	antiporter activity
EXW40_15955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW40_16005	COG3718	enzyme involved in inositol metabolism
EXW40_16010	COG0191	fructose-bisphosphate aldolase activity
EXW40_16035	COG0673	inositol 2-dehydrogenase activity
EXW40_16040	COG2814	Major facilitator Superfamily
EXW40_16045	COG1609	Transcriptional regulator
EXW40_16080	COG2002	toxin-antitoxin pair type II binding
EXW40_16100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW40_16110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW40_16165	COG4187	Peptidase family M20/M25/M40
EXW40_16180	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW40_16195	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW40_16235	COG1122	ATPase activity
EXW40_16260	COG1288	antiporter activity
EXW40_16265	COG2356	endonuclease I
EXW40_16270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW40_16275	COG3620	sequence-specific DNA binding
EXW40_16290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW40_16310	COG1785	Belongs to the alkaline phosphatase family
EXW40_16315	COG0778	Nitroreductase
EXW40_16320	COG1733	regulation of RNA biosynthetic process
EXW40_16340	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_16350	COG1131	(ABC) transporter
EXW40_16380	COG1595	DNA-templated transcription, initiation
EXW40_16395	COG1011	Hydrolase
EXW40_16400	COG2365	Tyrosine phosphatase family
EXW40_16425	COG0577	efflux transmembrane transporter activity
EXW40_16425	COG1136	(ABC) transporter
EXW40_16440	COG0628	permease
EXW40_16445	COG2261	transglycosylase associated protein
EXW40_16480	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW40_16490	COG1253	flavin adenine dinucleotide binding
EXW40_16495	COG0789	Transcriptional regulator
EXW40_16500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW40_16525	COG0697	spore germination
EXW40_16535	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW40_16540	COG3813	Protein conserved in bacteria
EXW40_16545	COG2706	6-phosphogluconolactonase activity
EXW40_16550	COG1070	Carbohydrate kinase
EXW40_16560	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW40_16565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW40_16570	COG4702	Belongs to the UPF0303 family
EXW40_16580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW40_16600	COG0384	phenazine biosynthesis protein PhzF
EXW40_16620	COG0318	PFAM AMP-dependent synthetase and ligase
EXW40_16625	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW40_16630	COG1733	regulation of RNA biosynthetic process
EXW40_16645	COG1191	sigma factor activity
EXW40_16665	COG1876	peptidase activity
EXW40_16710	COG0741	lytic transglycosylase activity
EXW40_16785	COG1522	sequence-specific DNA binding
EXW40_16790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW40_16795	COG0657	acetylesterase activity
EXW40_16805	COG2814	Major facilitator Superfamily
EXW40_16810	COG1309	transcriptional regulator
EXW40_16845	COG0814	amino acid
EXW40_16870	COG1151	hydroxylamine reductase activity
EXW40_16905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW40_16915	COG2072	flavoprotein involved in K transport
EXW40_16960	COG1695	Transcriptional regulator
EXW40_16965	COG0604	alcohol dehydrogenase
EXW40_16970	COG1113	amino acid transport
EXW40_16980	COG2814	Major facilitator Superfamily
EXW40_16995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW40_17000	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_17010	COG0534	Mate efflux family protein
EXW40_17015	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_17020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW40_17035	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW40_17040	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW40_17060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW40_17065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW40_17070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW40_17075	COG3739	integral membrane protein
EXW40_17095	COG0583	DNA-binding transcription factor activity
EXW40_17120	COG1193	negative regulation of DNA recombination
EXW40_17140	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW40_17145	COG1164	Oligoendopeptidase f
EXW40_17175	COG3781	membrane
EXW40_17190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW40_17255	COG0640	Transcriptional regulator
EXW40_17260	COG0604	alcohol dehydrogenase
EXW40_17265	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW40_17280	COG2808	Putative FMN-binding domain
EXW40_17285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW40_17295	COG0277	FAD linked oxidase domain protein
EXW40_17315	COG1285	pathogenesis
EXW40_17325	COG2514	catechol 2,3-dioxygenase activity
EXW40_17330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW40_17335	COG1126	abc transporter atp-binding protein
EXW40_17340	COG0765	amino acid transport
EXW40_17345	COG2720	vancomycin resistance protein
EXW40_17370	COG1278	Cold shock
EXW40_17380	COG0716	FMN binding
EXW40_17390	COG0494	nUDIX hydrolase
EXW40_17410	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_17420	COG0165	Argininosuccinate lyase
EXW40_17435	COG4145	pantothenate transmembrane transporter activity
EXW40_17445	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_17450	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_17460	COG1657	PFAM Prenyltransferase squalene oxidase
EXW40_17465	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW40_17470	COG2962	Rard protein
EXW40_17475	COG3326	Membrane
EXW40_17480	COG0531	amino acid
EXW40_17515	COG2226	methyltransferase
EXW40_17520	COG4166	transmembrane transport
EXW40_17525	COG4166	transmembrane transport
EXW40_17530	COG4166	transmembrane transport
EXW40_17540	COG1131	(ABC) transporter
EXW40_17560	COG0673	inositol 2-dehydrogenase activity
EXW40_17565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW40_17570	COG0187	DNA topoisomerase II activity
EXW40_17575	COG1832	CoA-binding protein
EXW40_17580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW40_17585	COG0745	RESPONSE REGULATOR receiver
EXW40_17595	COG1328	CTP reductase activity
EXW40_17595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW40_17605	COG4841	protein insertion into membrane
EXW40_17610	COG0824	Thioesterase
EXW40_17635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW40_17670	COG2274	protein secretion by the type I secretion system
EXW40_17675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW40_17705	COG2211	Major facilitator Superfamily
EXW40_17715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW40_17730	COG0183	Belongs to the thiolase family
EXW40_17735	COG0318	PFAM AMP-dependent synthetase and ligase
EXW40_17740	COG1268	BioY protein
EXW40_17745	COG0318	PFAM AMP-dependent synthetase and ligase
EXW40_17750	COG1396	sequence-specific DNA binding
EXW40_17795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW40_17810	COG5002	protein histidine kinase activity
EXW40_17820	COG0400	carboxylic ester hydrolase activity
EXW40_17825	COG0346	lactoylglutathione lyase activity
EXW40_17830	COG0069	glutamate synthase activity
EXW40_17835	COG1902	pentaerythritol trinitrate reductase activity
EXW40_17845	COG1329	Transcriptional regulator
EXW40_17850	COG0010	Belongs to the arginase family
EXW40_17860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW40_17865	COG2986	histidine ammonia-lyase
EXW40_17875	COG2226	methyltransferase
EXW40_17905	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW40_17910	COG0785	Cytochrome C biogenesis protein
EXW40_17925	COG1473	amidohydrolase
EXW40_17930	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW40_17935	COG1131	(ABC) transporter
EXW40_17945	COG0583	DNA-binding transcription factor activity
EXW40_17955	COG1346	cytolysis
EXW40_17970	COG0730	response to heat
EXW40_17980	COG3409	Peptidoglycan-binding domain 1 protein
EXW40_17980	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW40_18000	COG1132	(ABC) transporter
EXW40_18005	COG1132	(ABC) transporter
EXW40_18010	COG3763	UPF0154 protein
EXW40_18030	COG3639	organic phosphonate transmembrane transporter activity
EXW40_18040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW40_18045	COG0737	Belongs to the 5'-nucleotidase family
EXW40_18055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW40_18060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW40_18075	COG1695	Transcriptional regulator
EXW40_18080	COG0174	glutamine synthetase
EXW40_18085	COG0789	Transcriptional regulator
EXW40_18090	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW40_18095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW40_18100	COG2860	membrane
EXW40_18105	COG0464	growth
EXW40_18125	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW40_18135	COG1388	LysM domain
EXW40_18135	COG3584	3D domain protein
EXW40_18140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW40_18140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW40_18140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW40_18145	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW40_18150	COG1349	DNA-binding transcription factor activity
EXW40_18155	COG1979	alcohol dehydrogenase
EXW40_18160	COG2322	membrane
EXW40_18170	COG1113	amino acid transport
EXW40_18185	COG1473	amidohydrolase
EXW40_18190	COG1408	metallophosphoesterase
EXW40_18195	COG2116	formate transmembrane transporter activity
EXW40_18210	COG2217	Heavy metal translocating P-type atpase
EXW40_18215	COG2608	mercury ion transmembrane transporter activity
EXW40_18220	COG1937	Protein conserved in bacteria
EXW40_18240	COG2819	hydrolase of the alpha beta superfamily
EXW40_18245	COG1120	ATPase activity
EXW40_18250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW40_18255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW40_18260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW40_18265	COG0708	Exodeoxyribonuclease III
EXW40_18270	COG2169	Transcriptional regulator
EXW40_18275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW40_18280	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW40_18285	COG2706	6-phosphogluconolactonase activity
EXW40_18290	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW40_18295	COG2364	Membrane
EXW40_18305	COG0346	lactoylglutathione lyase activity
EXW40_18310	COG3300	MHYT domain
EXW40_18310	COG5001	Diguanylate cyclase
EXW40_18350	COG1346	cytolysis
EXW40_18360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW40_18365	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW40_18365	COG0596	Alpha beta hydrolase
EXW40_18370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW40_18385	COG2188	Transcriptional regulator
EXW40_18390	COG2723	6-phospho-beta-galactosidase activity
EXW40_18400	COG3773	Cell wall hydrolase
EXW40_18410	COG1368	sulfuric ester hydrolase activity
EXW40_18415	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW40_18430	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW40_18440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW40_18445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW40_18455	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW40_18460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW40_18465	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW40_18470	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW40_18470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW40_18480	COG2359	stage V sporulation protein S
EXW40_18485	COG1692	metallophosphoesterase
EXW40_18490	COG1418	mRNA catabolic process
EXW40_18495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW40_18500	COG1058	Belongs to the CinA family
EXW40_18500	COG1546	Belongs to the CinA family
EXW40_18505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW40_18510	COG1426	Protein conserved in bacteria
EXW40_18525	COG0300	oxidoreductase activity
EXW40_18530	COG0612	Peptidase, M16
EXW40_18535	COG0612	Peptidase, M16
EXW40_18540	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW40_18545	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW40_18550	COG3845	ABC transporter
EXW40_18555	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW40_18560	COG2188	Transcriptional regulator
EXW40_18565	COG1674	ftsk spoiiie
EXW40_18575	COG0740	serine-type endopeptidase activity
EXW40_18580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW40_18590	COG0527	aspartate kinase activity
EXW40_18595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW40_18600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW40_18605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW40_18610	COG1873	PFAM PRC-barrel domain
EXW40_18615	COG0612	Peptidase, M16
EXW40_18620	COG0726	polysaccharide deacetylase
EXW40_18625	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW40_18635	COG0196	riboflavin kinase activity
EXW40_18645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW40_18650	COG1550	Protein conserved in bacteria
EXW40_18655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW40_18660	COG1358	cellular component organization or biogenesis
EXW40_18665	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW40_18670	COG0195	Participates in both transcription termination and antitermination
EXW40_18675	COG0779	Required for maturation of 30S ribosomal subunits
EXW40_18685	COG0442	prolyl-tRNA aminoacylation
EXW40_18690	COG0750	zinc metalloprotease
EXW40_18700	COG4589	Belongs to the CDS family
EXW40_18710	COG0233	cytoplasmic translational termination
EXW40_18715	COG0528	UMP kinase activity
EXW40_18720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW40_18725	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW40_18730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW40_18735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW40_18740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW40_18745	COG4974	Belongs to the 'phage' integrase family
EXW40_18750	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW40_18755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW40_18760	COG0758	DNA mediated transformation
EXW40_18765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW40_18770	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW40_18775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW40_18790	COG0335	large ribosomal subunit rRNA binding
EXW40_18795	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW40_18800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW40_18805	COG1837	Belongs to the UPF0109 family
EXW40_18815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW40_18820	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EXW40_18825	COG0552	protein localization to endoplasmic reticulum
EXW40_18830	COG1196	nuclear chromosome segregation
EXW40_18835	COG0571	ribonuclease III activity
EXW40_18840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW40_18845	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_18850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW40_18855	COG0416	fatty acid biosynthetic process
EXW40_18860	COG1349	DNA-binding transcription factor activity
EXW40_18860	COG2050	protein possibly involved in aromatic compounds catabolism
EXW40_18865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW40_18870	COG1461	Dihydroxyacetone kinase
EXW40_18875	COG1302	Protein conserved in bacteria
EXW40_18890	COG1564	THIamine pyrophosphokinase
EXW40_18895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW40_18905	COG0515	serine threonine protein kinase
EXW40_18905	COG2815	serine threonine protein kinase
EXW40_18910	COG0631	protein serine/threonine phosphatase activity
EXW40_18915	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW40_18920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW40_18920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW40_18925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW40_18930	COG0242	peptide deformylase activity
EXW40_18935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW40_18940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW40_18945	COG1758	RNA polymerase activity
EXW40_18960	COG1561	YicC-like family, N-terminal region
EXW40_18965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW40_18980	COG0006	proline dipeptidase activity
EXW40_19000	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW40_19020	COG0167	dihydroorotate dehydrogenase activity
EXW40_19025	COG0543	2 iron, 2 sulfur cluster binding
EXW40_19030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW40_19040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW40_19045	COG0540	Belongs to the ATCase OTCase family
EXW40_19055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW40_19060	COG0564	pseudouridine synthase activity
EXW40_19065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW40_19075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW40_19080	COG3599	regulation of cell shape
EXW40_19085	COG2302	S4 RNA-binding domain
EXW40_19090	COG0762	integral membrane protein
EXW40_19095	COG1799	cell septum assembly
EXW40_19100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW40_19110	COG1873	PFAM PRC-barrel domain
EXW40_19115	COG1191	sigma factor activity
EXW40_19120	COG1191	sigma factor activity
EXW40_19130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW40_19135	COG0849	cell division
EXW40_19140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW40_19155	COG0772	Belongs to the SEDS family
EXW40_19160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW40_19165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW40_19170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW40_19175	COG0768	penicillin binding
EXW40_19180	COG0768	penicillin binding
EXW40_19190	COG0275	rRNA processing
EXW40_19195	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW40_19200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW40_19205	COG0454	-acetyltransferase
EXW40_19215	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW40_19220	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW40_19225	COG1323	Belongs to the UPF0348 family
EXW40_19230	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW40_19235	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW40_19240	COG3314	Sporulation integral membrane protein YlbJ
EXW40_19250	COG0742	ribosomal rna small subunit methyltransferase
EXW40_19260	COG4471	UPF0298 protein
EXW40_19265	COG3679	Belongs to the UPF0342 family
EXW40_19270	COG0406	alpha-ribazole phosphatase activity
EXW40_19285	COG2340	Cysteine-rich secretory protein family
EXW40_19295	COG3336	cytochrome c oxidase
EXW40_19320	COG0109	protoheme IX farnesyltransferase activity
EXW40_19325	COG1612	heme a metabolic process
EXW40_19330	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW40_19340	COG0772	Belongs to the SEDS family
EXW40_19345	COG4838	Belongs to the UPF0358 family
EXW40_19350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW40_19355	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW40_19365	COG4896	Protein conserved in bacteria
EXW40_19380	COG1217	gtp-binding protein TYPA
EXW40_19390	COG0483	inositol monophosphate 1-phosphatase activity
EXW40_19400	COG4493	Belongs to the UPF0637 family
EXW40_19405	COG4476	Belongs to the UPF0223 family
EXW40_19415	COG1982	Orn Lys Arg decarboxylase major
EXW40_19460	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW40_19465	COG0022	dehydrogenase e1 component
EXW40_19470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW40_19485	COG0561	phosphatase activity
EXW40_19495	COG5503	Protein of unknown function (DUF1447)
EXW40_19500	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW40_19505	COG0569	domain protein
EXW40_19515	COG1473	amidohydrolase
EXW40_19520	COG2171	N-acyltransferase activity
EXW40_19525	COG0583	DNA-binding transcription factor activity
EXW40_19530	COG0517	IMP dehydrogenase activity
EXW40_19540	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW40_19550	COG4703	Protein of unknown function (DUF1797)
EXW40_19565	COG2200	EAL domain
EXW40_19570	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_19575	COG1408	metallophosphoesterase
EXW40_19620	COG2814	Major facilitator Superfamily
EXW40_19630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW40_19640	COG3209	COG3209 Rhs family protein
EXW40_19650	COG2205	protein histidine kinase activity
EXW40_19660	COG0436	Aminotransferase
EXW40_19665	COG1609	Transcriptional regulator
EXW40_19670	COG3833	ABC-type maltose transport systems, permease component
EXW40_19675	COG1175	transmembrane transport
EXW40_19680	COG2182	Extracellular solute-binding protein
EXW40_19690	COG0366	Alpha amylase catalytic
EXW40_19695	COG3842	ATPase activity
EXW40_19735	COG0183	Belongs to the thiolase family
EXW40_19770	COG1695	Transcriptional regulator
EXW40_19775	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_19785	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW40_19790	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW40_19795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW40_19800	COG0436	Aminotransferase
EXW40_19805	COG1850	ribulose-bisphosphate carboxylase activity
EXW40_19810	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW40_19835	COG2084	Dehydrogenase
EXW40_19845	COG2199	diguanylate cyclase activity
EXW40_19850	COG0778	Nitroreductase
EXW40_19875	COG1263	PTS System
EXW40_19875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW40_19875	COG2190	(PTS) system
EXW40_19880	COG3711	transcriptional antiterminator
EXW40_19890	COG2188	Transcriptional regulator
EXW40_19895	COG0363	glucosamine-6-phosphate deaminase activity
EXW40_19900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW40_19910	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW40_19920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW40_19930	COG1547	Domain of unknown function (DUF309)
EXW40_19940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW40_19945	COG4086	secreted protein
EXW40_19950	COG0561	phosphatase activity
EXW40_19955	COG0697	spore germination
EXW40_19970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW40_20010	COG1686	Belongs to the peptidase S11 family
EXW40_20015	COG1725	Transcriptional regulator
EXW40_20020	COG1131	(ABC) transporter
EXW40_20045	COG1846	Transcriptional regulator
EXW40_20060	COG0598	Magnesium transport protein CorA
EXW40_20075	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW40_20085	COG4974	Belongs to the 'phage' integrase family
EXW40_20095	COG0735	belongs to the Fur family
EXW40_20100	COG1300	Membrane
EXW40_20120	COG0667	Aldo Keto reductase
EXW40_20125	COG0656	L-ascorbic acid biosynthetic process
EXW40_20130	COG0456	acetyltransferase
EXW40_20130	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW40_20140	COG0737	Belongs to the 5'-nucleotidase family
EXW40_20140	COG1525	nuclease
EXW40_20140	COG4085	toxin activity
EXW40_20150	COG0596	Alpha beta hydrolase
EXW40_20155	COG2056	Na+-H+ antiporter family
EXW40_20160	COG1609	Transcriptional regulator
EXW40_20165	COG0456	acetyltransferase
EXW40_20170	COG1073	alpha beta
EXW40_20190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW40_20190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW40_20195	COG0307	riboflavin synthase, alpha
EXW40_20200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW40_20200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW40_20220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW40_20225	COG4106	trans-aconitate 2-methyltransferase activity
EXW40_20230	COG2226	methyltransferase
EXW40_20230	COG1073	alpha beta
EXW40_20235	COG0156	8-amino-7-oxononanoate synthase activity
EXW40_20245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW40_20255	COG1757	Na H antiporter
EXW40_20260	COG0737	Belongs to the 5'-nucleotidase family
EXW40_20270	COG1522	sequence-specific DNA binding
EXW40_20300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW40_20305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXW40_20315	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW40_20325	COG0300	oxidoreductase activity
EXW40_20330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW40_20335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW40_20340	COG1760	l-serine dehydratase
EXW40_20345	COG1760	l-serine dehydratase
EXW40_20355	COG1234	tRNA 3'-trailer cleavage
EXW40_20380	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW40_20385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW40_20395	COG1376	ErfK ybiS ycfS ynhG family protein
EXW40_20400	COG4129	membrane
EXW40_20405	COG1126	abc transporter atp-binding protein
EXW40_20410	COG0765	amino acid transport
EXW40_20415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW40_20425	COG2816	NAD+ diphosphatase activity
EXW40_20430	COG2323	membrane
EXW40_20435	COG0772	Belongs to the SEDS family
EXW40_20445	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW40_20450	COG0022	dehydrogenase e1 component
EXW40_20455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW40_20460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW40_20465	COG3426	butyrate kinase activity
EXW40_20475	COG0280	phosphate acetyltransferase
EXW40_20485	COG3290	protein histidine kinase activity
EXW40_20485	COG3829	transcription factor binding
EXW40_20495	COG0584	glycerophosphoryl diester phosphodiesterase
EXW40_20500	COG3093	addiction module antidote protein HigA
EXW40_20540	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW40_20585	COG0745	RESPONSE REGULATOR receiver
EXW40_20595	COG0750	zinc metalloprotease
EXW40_20600	COG0497	DNA recombination
EXW40_20605	COG1438	arginine binding
EXW40_20610	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW40_20615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW40_20620	COG0142	geranyltranstransferase activity
EXW40_20625	COG1722	exodeoxyribonuclease VII activity
EXW40_20630	COG1570	exodeoxyribonuclease VII activity
EXW40_20635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW40_20640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW40_20645	COG1302	Protein conserved in bacteria
EXW40_20650	COG0439	Biotin carboxylase
EXW40_20655	COG0511	ligase activity, forming carbon-carbon bonds
EXW40_20700	COG3854	ATPases associated with a variety of cellular activities
EXW40_20720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW40_20725	COG0006	proline dipeptidase activity
EXW40_20730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW40_20740	COG3872	metal-dependent enzyme
EXW40_20750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW40_20755	COG1321	iron dependent repressor
EXW40_20785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW40_20795	COG1609	Transcriptional regulator
EXW40_20805	COG2076	Multidrug Resistance protein
EXW40_20810	COG2076	Multidrug Resistance protein
EXW40_20840	COG1131	(ABC) transporter
EXW40_20845	COG1725	Transcriptional regulator
EXW40_20860	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW40_20865	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW40_20870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW40_20875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW40_20905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW40_20930	COG4970	Tfp pilus assembly protein FimT
EXW40_20940	COG1459	type II secretion system
EXW40_20945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW40_21000	COG0646	methionine synthase
EXW40_21000	COG1410	methionine synthase
EXW40_21005	COG0646	methionine synthase
EXW40_21005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW40_21010	COG0626	cystathionine gamma-synthase activity
EXW40_21015	COG0626	cystathionine gamma-synthase activity
EXW40_21030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW40_21040	COG1940	carbohydrate kinase activity
EXW40_21045	COG4483	Protein conserved in bacteria
EXW40_21050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW40_21055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW40_21060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW40_21065	COG0704	Plays a role in the regulation of phosphate uptake
EXW40_21075	COG0581	inorganic phosphate transmembrane transporter activity
EXW40_21080	COG0573	inorganic phosphate transmembrane transporter activity
EXW40_21085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW40_21090	COG0768	penicillin binding
EXW40_21095	COG0477	Major facilitator Superfamily
EXW40_21100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW40_21120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW40_21125	COG0735	belongs to the Fur family
EXW40_21130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW40_21135	COG1121	(ABC) transporter
EXW40_21140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW40_21150	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW40_21165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW40_21170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW40_21175	COG2384	SAM-dependent methyltransferase
EXW40_21185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW40_21190	COG0358	DNA primase activity
EXW40_21200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW40_21205	COG0517	IMP dehydrogenase activity
EXW40_21210	COG1381	Involved in DNA repair and RecF pathway recombination
EXW40_21220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW40_21225	COG0295	cytidine deaminase activity
EXW40_21230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW40_21235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW40_21240	COG1480	7TM receptor with intracellular HD hydrolase
EXW40_21245	COG1702	phosphate starvation-inducible protein PhoH
EXW40_21260	COG1610	YqeY-like protein
EXW40_21265	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW40_21270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW40_21275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW40_21285	COG0484	heat shock protein binding
EXW40_21290	COG0443	Heat shock 70 kDa protein
EXW40_21300	COG1420	regulation of RNA biosynthetic process
EXW40_21305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW40_21310	COG1733	regulation of RNA biosynthetic process
EXW40_21315	COG0481	GTPase activity
EXW40_21325	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW40_21330	COG0268	Binds directly to 16S ribosomal RNA
EXW40_21335	COG1466	dna polymerase III delta subunit
EXW40_21345	COG0658	competence protein
EXW40_21345	COG2333	competence protein COMEC
EXW40_21350	COG2131	deaminase
EXW40_21355	COG1555	photosystem II stabilization
EXW40_21355	COG1596	polysaccharide export
EXW40_21360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW40_21365	COG2226	methyltransferase
EXW40_21370	COG0799	negative regulation of ribosome biogenesis
EXW40_21375	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW40_21380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW40_21385	COG1534	Rna-binding protein
EXW40_21390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW40_21395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW40_21400	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW40_21410	COG0688	phosphatidylethanolamine metabolic process
EXW40_21420	COG1595	DNA-templated transcription, initiation
EXW40_21425	COG2357	RelA SpoT domain protein
EXW40_21435	COG1785	Belongs to the alkaline phosphatase family
EXW40_21445	COG2267	carboxylic ester hydrolase activity
EXW40_21480	COG1404	Belongs to the peptidase S8 family
EXW40_21485	COG3186	Phenylalanine-4-hydroxylase
EXW40_21490	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW40_21495	COG2514	catechol 2,3-dioxygenase activity
EXW40_21500	COG2259	Doxx family
EXW40_21540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW40_21550	COG1012	belongs to the aldehyde dehydrogenase family
EXW40_21550	COG1454	alcohol dehydrogenase
EXW40_21555	COG0626	cystathionine gamma-synthase activity
EXW40_21560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW40_21565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW40_21570	COG2226	methyltransferase
EXW40_21585	COG0768	penicillin binding
EXW40_21590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW40_21595	COG0572	uridine kinase
EXW40_21600	COG0826	peptidase U32
EXW40_21605	COG0826	peptidase U32
EXW40_21610	COG4122	O-methyltransferase activity
EXW40_21615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW40_21625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW40_21630	COG4472	Bacterial protein of unknown function (DUF965)
EXW40_21635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW40_21645	COG0628	permease
EXW40_21665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW40_21675	COG0482	sulfurtransferase activity
EXW40_21680	COG1104	cysteine desulfurase activity
EXW40_21685	COG1959	2 iron, 2 sulfur cluster binding
EXW40_21690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW40_21700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW40_21705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW40_21715	COG1490	D-aminoacyl-tRNA deacylase activity
EXW40_21720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW40_21725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW40_21730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW40_21730	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW40_21735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW40_21740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW40_21740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW40_21750	COG2244	polysaccharide biosynthetic process
EXW40_21755	COG2323	membrane
EXW40_21765	COG1862	Preprotein translocase
EXW40_21770	COG0343	queuine tRNA-ribosyltransferase activity
EXW40_21785	COG2255	four-way junction helicase activity
EXW40_21790	COG0632	four-way junction helicase activity
EXW40_21795	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW40_21820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW40_21825	COG0157	Belongs to the NadC ModD family
EXW40_21830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW40_21835	COG1104	cysteine desulfurase activity
EXW40_21840	COG1827	regulation of RNA biosynthetic process
EXW40_21845	COG2258	MOSC domain
EXW40_21850	COG0077	Prephenate dehydratase
EXW40_21855	COG0577	efflux transmembrane transporter activity
EXW40_21860	COG0577	efflux transmembrane transporter activity
EXW40_21865	COG1136	(ABC) transporter
EXW40_21870	COG5002	protein histidine kinase activity
EXW40_21875	COG0745	RESPONSE REGULATOR receiver
EXW40_21880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW40_21885	COG3290	protein histidine kinase activity
EXW40_21895	COG2868	ribosomal protein
EXW40_21905	COG1530	ribonuclease E activity
EXW40_21910	COG1994	Peptidase M50
EXW40_21915	COG0739	heme binding
EXW40_21920	COG2894	cell division
EXW40_21925	COG0850	regulation of cytokinetic process
EXW40_21940	COG1077	Cell shape determining protein MreB Mrl
EXW40_21980	COG1404	Belongs to the peptidase S8 family
EXW40_21985	COG1222	aaa ATPase
EXW40_21995	COG0424	maF-like protein
EXW40_22010	COG0285	dihydrofolate synthase activity
EXW40_22025	COG1388	LysM domain
EXW40_22030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW40_22035	COG0113	porphobilinogen synthase activity
EXW40_22040	COG1587	Uroporphyrinogen-III synthase
EXW40_22045	COG0181	hydroxymethylbilane synthase activity
EXW40_22050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW40_22055	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW40_22060	COG1846	Transcriptional regulator
EXW40_22065	COG1764	response to oxidative stress
EXW40_22070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW40_22080	COG1067	ATP-dependent peptidase activity
EXW40_22080	COG0470	DNA polymerase III
EXW40_22090	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW40_22120	COG0622	Phosphoesterase
EXW40_22130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW40_22135	COG5401	PFAM Sporulation and spore germination
EXW40_22145	COG0477	Major facilitator Superfamily
EXW40_22155	COG1309	transcriptional regulator
EXW40_22165	COG2197	response regulator
EXW40_22170	COG2233	PERMEase
EXW40_22175	COG0402	S-adenosylhomocysteine deaminase activity
EXW40_22180	COG1983	PspC domain protein
EXW40_22185	COG1396	sequence-specific DNA binding
EXW40_22190	COG0697	spore germination
EXW40_22200	COG1959	2 iron, 2 sulfur cluster binding
EXW40_22205	COG1668	transmembrane transport
EXW40_22210	COG4152	abc transporter atp-binding protein
EXW40_22215	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW40_22220	COG1360	Flagellar Motor Protein
EXW40_22225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW40_22235	COG1876	peptidase activity
EXW40_22240	COG0824	Thioesterase
EXW40_22245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW40_22250	COG1053	succinate dehydrogenase
EXW40_22255	COG2009	succinate dehydrogenase
EXW40_22260	COG1719	4-vinyl reductase, 4VR
EXW40_22265	COG0322	excinuclease ABC activity
EXW40_22270	COG3118	belongs to the thioredoxin family
EXW40_22275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW40_22280	COG2086	electron transfer activity
EXW40_22285	COG1024	Enoyl-CoA hydratase
EXW40_22290	COG1309	transcriptional regulator
EXW40_22295	COG0318	PFAM AMP-dependent synthetase and ligase
EXW40_22320	COG2318	DinB family
EXW40_22345	COG1131	(ABC) transporter
EXW40_22350	COG2205	protein histidine kinase activity
EXW40_22355	COG0745	RESPONSE REGULATOR receiver
EXW40_22360	COG4895	conserved protein (DUF2196)
EXW40_22365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW40_22375	COG2329	Antibiotic biosynthesis monooxygenase
EXW40_22380	COG4509	Sortase family
EXW40_22385	COG1120	ATPase activity
EXW40_22400	COG5386	Cell surface protein
EXW40_22410	COG5386	Cell surface protein
EXW40_22415	COG1114	Component of the transport system for branched-chain amino acids
EXW40_22425	COG1193	negative regulation of DNA recombination
EXW40_22430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW40_22430	COG1796	DNA polymerase
EXW40_22435	COG1286	toxin biosynthetic process
EXW40_22440	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW40_22445	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW40_22480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW40_22485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW40_22495	COG1418	mRNA catabolic process
EXW40_22525	COG2814	Major facilitator Superfamily
EXW40_22530	COG1566	PFAM secretion protein HlyD family protein
EXW40_22535	COG1309	transcriptional regulator
EXW40_22540	COG1363	Peptidase, m42
EXW40_22550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW40_22565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW40_22575	COG1484	DNA-dependent DNA replication
EXW40_22580	COG3611	Membrane attachment protein
EXW40_22585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW40_22590	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW40_22595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW40_22600	COG0237	dephospho-CoA kinase activity
EXW40_22605	COG1971	Probably functions as a manganese efflux pump
EXW40_22615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW40_22615	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW40_22620	COG5002	protein histidine kinase activity
EXW40_22625	COG0745	RESPONSE REGULATOR receiver
EXW40_22640	COG0039	L-malate dehydrogenase activity
EXW40_22645	COG0538	isocitrate dehydrogenase activity
EXW40_22650	COG0372	Belongs to the citrate synthase family
EXW40_22665	COG0628	permease
EXW40_22670	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW40_22680	COG0205	6-phosphofructokinase activity
EXW40_22690	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW40_22695	COG1725	Transcriptional regulator
EXW40_22700	COG0281	malic enzyme
EXW40_22705	COG0587	DNA-directed DNA polymerase activity
EXW40_22720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW40_22740	COG4109	DRTGG domain
EXW40_22745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW40_22750	COG0006	proline dipeptidase activity
EXW40_22775	COG0662	Cupin 2, conserved barrel domain protein
EXW40_22785	COG1476	TRANSCRIPTIONal
EXW40_22800	COG1028	Short-chain dehydrogenase reductase Sdr
EXW40_22805	COG0589	response to stress
EXW40_22820	COG0165	Argininosuccinate lyase
EXW40_22825	COG0137	argininosuccinate synthase activity
EXW40_22840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW40_22860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW40_22865	COG0827	DNA restriction-modification system
EXW40_22870	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW40_22875	COG3874	Sporulation protein YtfJ
EXW40_22890	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW40_22900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW40_22915	COG1104	cysteine desulfurase activity
EXW40_22925	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW40_22935	COG1309	transcriptional regulator
EXW40_22940	COG1956	GAF domain-containing protein
EXW40_22945	COG0626	cystathionine gamma-synthase activity
EXW40_22950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW40_22975	COG1595	DNA-templated transcription, initiation
EXW40_22985	COG0110	maltose O-acetyltransferase activity
EXW40_22990	COG0456	acetyltransferase
EXW40_22995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW40_23000	COG0454	-acetyltransferase
EXW40_23005	COG0517	IMP dehydrogenase activity
EXW40_23010	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW40_23025	COG0745	RESPONSE REGULATOR receiver
EXW40_23030	COG5002	protein histidine kinase activity
EXW40_23035	COG0666	response to abiotic stimulus
EXW40_23045	COG1970	mechanosensitive ion channel activity
EXW40_23065	COG1609	Transcriptional regulator
EXW40_23070	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW40_23070	COG1605	Chorismate mutase
EXW40_23075	COG1605	Chorismate mutase
EXW40_23075	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW40_23080	COG4851	CamS sex pheromone cAM373 precursor
EXW40_23085	COG3118	belongs to the thioredoxin family
EXW40_23095	COG2309	aminopeptidase activity
EXW40_23115	COG0697	spore germination
EXW40_23120	COG0789	Transcriptional regulator
EXW40_23125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW40_23135	COG1674	ftsk spoiiie
EXW40_23150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW40_23155	COG4848	Belongs to the UPF0354 family
EXW40_23160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW40_23165	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW40_23170	COG1363	Peptidase, m42
EXW40_23180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW40_23185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW40_23195	COG0510	thiamine kinase activity
EXW40_23200	COG1523	belongs to the glycosyl hydrolase 13 family
EXW40_23210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW40_23215	COG1349	DNA-binding transcription factor activity
EXW40_23220	COG1187	pseudouridine synthase activity
EXW40_23225	COG2244	polysaccharide biosynthetic process
EXW40_23230	COG2081	HI0933 family
EXW40_23235	COG2814	Major facilitator Superfamily
EXW40_23245	COG3832	glyoxalase III activity
EXW40_23265	COG1329	Transcriptional regulator
EXW40_23290	COG0314	molybdopterin synthase activity
EXW40_23295	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW40_23300	COG0303	'Molybdopterin
EXW40_23305	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW40_23310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW40_23315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW40_23340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW40_23350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW40_23390	COG0495	leucyl-tRNA aminoacylation
EXW40_23395	COG2814	Major facilitator Superfamily
EXW40_23400	COG0475	glutathione-regulated potassium exporter activity
EXW40_23405	COG0490	domain, Protein
EXW40_23410	COG0582	viral genome integration into host DNA
EXW40_23425	COG1136	(ABC) transporter
EXW40_23445	COG1242	4 iron, 4 sulfur cluster binding
EXW40_23450	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW40_23470	COG2267	carboxylic ester hydrolase activity
EXW40_23475	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW40_23480	COG0671	phosphoesterase, PA-phosphatase related
EXW40_23485	COG0438	transferase activity, transferring glycosyl groups
EXW40_23490	COG0746	molybdenum cofactor guanylyltransferase activity
EXW40_23495	COG0521	Mo-molybdopterin cofactor biosynthetic process
EXW40_23510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW40_23515	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW40_23560	COG5002	protein histidine kinase activity
EXW40_23565	COG3852	Histidine kinase
EXW40_23570	COG0753	catalase activity
EXW40_23575	COG2267	carboxylic ester hydrolase activity
EXW40_23585	COG1368	sulfuric ester hydrolase activity
EXW40_23595	COG4895	conserved protein (DUF2196)
EXW40_23610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW40_23615	COG1116	anion transmembrane transporter activity
EXW40_23620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW40_23640	COG0494	nUDIX hydrolase
EXW40_23680	COG2076	Multidrug Resistance protein
EXW40_23685	COG2076	Multidrug Resistance protein
EXW40_23690	COG0789	Transcriptional regulator
EXW40_23695	COG1854	S-ribosylhomocysteine lyase activity
EXW40_23705	COG0288	reversible hydration of carbon dioxide
EXW40_23710	COG1271	oxidase subunit
EXW40_23715	COG1294	oxidase, subunit
EXW40_23740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW40_23765	COG1842	Phage shock protein A
EXW40_23790	COG3859	Proton-coupled thiamine transporter YuaJ
EXW40_23795	COG5002	protein histidine kinase activity
EXW40_23800	COG0745	RESPONSE REGULATOR receiver
EXW40_23825	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW40_23830	COG1597	lipid kinase activity
EXW40_23850	COG4977	sequence-specific DNA binding
EXW40_23860	COG0577	efflux transmembrane transporter activity
EXW40_23865	COG1136	(ABC) transporter
EXW40_23870	COG2207	Transcriptional regulator
EXW40_23870	COG3708	Transcriptional regulator
EXW40_23880	COG1131	(ABC) transporter
EXW40_23890	COG5658	integral membrane protein
EXW40_23895	COG0640	Transcriptional regulator
EXW40_23900	COG0745	RESPONSE REGULATOR receiver
EXW40_23905	COG2205	protein histidine kinase activity
EXW40_23910	COG0577	efflux transmembrane transporter activity
EXW40_23915	COG0577	efflux transmembrane transporter activity
EXW40_23920	COG1136	(ABC) transporter
EXW40_23925	COG0577	efflux transmembrane transporter activity
EXW40_23940	COG2188	Transcriptional regulator
EXW40_23960	COG3964	amidohydrolase
EXW40_23990	COG4948	Mandelate Racemase Muconate Lactonizing
EXW40_23995	COG0318	PFAM AMP-dependent synthetase and ligase
EXW40_24000	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW40_24005	COG0596	Alpha beta hydrolase
EXW40_24010	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW40_24015	COG1169	isochorismate synthase
EXW40_24020	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW40_24025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW40_24030	COG1278	Cold shock
EXW40_24040	COG0789	Transcriptional regulator
EXW40_24050	COG0058	SHG alpha-glucan phosphorylase activity
EXW40_24060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW40_24065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW40_24070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW40_24215	COG1285	pathogenesis
EXW40_24220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW40_24230	COG0166	Belongs to the GPI family
EXW40_24240	COG2155	Conserved Protein
EXW40_24245	COG1098	S1 RNA binding domain
EXW40_24250	COG0436	Aminotransferase
EXW40_24255	COG1522	sequence-specific DNA binding
EXW40_24260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW40_24265	COG2267	carboxylic ester hydrolase activity
EXW40_24275	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW40_24290	COG5018	Exonuclease
EXW40_24295	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW40_24315	COG2050	protein possibly involved in aromatic compounds catabolism
EXW40_24325	COG1268	BioY protein
EXW40_24330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW40_24335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW40_24345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW40_24350	COG3584	3D domain protein
EXW40_24365	COG1252	NADH dehydrogenase
EXW40_24370	COG0492	ferredoxin-NADP+ reductase activity
EXW40_24375	COG3708	Transcriptional regulator
EXW40_24390	COG1683	Conserved Protein
EXW40_24415	COG0316	Belongs to the HesB IscA family
EXW40_24420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW40_24425	COG4844	belongs to the
EXW40_24430	COG1252	NADH dehydrogenase
EXW40_24440	COG0390	transport system, permease component
EXW40_24445	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW40_24495	COG4837	Protein of unknown function (DUF1462)
EXW40_24500	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW40_24510	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW40_24515	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW40_24530	COG0647	UMP catabolic process
EXW40_24540	COG2445	Protein of unknown function DUF86
EXW40_24545	COG1494	fructose-1,6-bisphosphatase
EXW40_24560	COG4470	Protein conserved in bacteria
EXW40_24570	COG0789	Transcriptional regulator
EXW40_24575	COG4377	Putative membrane peptidase family (DUF2324)
EXW40_24595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW40_24600	COG0739	heme binding
EXW40_24610	COG3377	Domain of unknown function (DUF1805)
EXW40_24615	COG0737	Belongs to the 5'-nucleotidase family
EXW40_24620	COG1695	Transcriptional regulator
EXW40_24630	COG0719	Fe-S assembly protein
EXW40_24635	COG0822	iron-sulfur transferase activity
EXW40_24640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW40_24645	COG0719	Fe-S assembly protein
EXW40_24650	COG0396	ATPase activity
EXW40_24655	COG1464	Belongs to the NlpA lipoprotein family
EXW40_24660	COG1464	Belongs to the NlpA lipoprotein family
EXW40_24665	COG2011	ABC-type metal ion transport system permease component
EXW40_24680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW40_24685	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW40_24690	COG0509	glycine decarboxylation via glycine cleavage system
EXW40_24695	COG1393	Belongs to the ArsC family
EXW40_24760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW40_24765	COG1960	acyl-CoA dehydrogenase activity
EXW40_24770	COG0183	Belongs to the thiolase family
EXW40_24775	COG1024	Enoyl-CoA hydratase
EXW40_24775	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW40_24785	COG1686	Belongs to the peptidase S11 family
EXW40_24790	COG0506	proline dehydrogenase activity
EXW40_24800	COG0011	TIGRFAM Protein of
EXW40_24805	COG0840	transmembrane signaling receptor activity
EXW40_24820	COG2814	Major facilitator Superfamily
EXW40_24825	COG0531	amino acid
EXW40_24850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW40_24880	COG0586	Pfam SNARE associated Golgi protein
EXW40_24890	COG1376	ErfK ybiS ycfS ynhG family protein
EXW40_24895	COG0745	RESPONSE REGULATOR receiver
EXW40_24900	COG5002	protein histidine kinase activity
EXW40_24910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW40_24920	COG0840	transmembrane signaling receptor activity
EXW40_24925	COG0840	transmembrane signaling receptor activity
EXW40_24930	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW40_24935	COG3227	Zinc metalloprotease (Elastase)
EXW40_24940	COG1741	Belongs to the pirin family
EXW40_24955	COG0586	Pfam SNARE associated Golgi protein
EXW40_24960	COG0475	glutathione-regulated potassium exporter activity
EXW40_24965	COG0490	domain, Protein
EXW40_24970	COG1115	amino acid carrier protein
EXW40_24980	COG0783	Belongs to the Dps family
EXW40_24990	COG2318	DinB family
EXW40_25000	COG1611	Belongs to the LOG family
EXW40_25010	COG1528	Iron-storage protein
EXW40_25015	COG2311	Membrane
EXW40_25020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW40_25025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW40_25030	COG1115	amino acid carrier protein
EXW40_25035	COG2910	NAD(P)H-binding
EXW40_25065	COG0656	L-ascorbic acid biosynthetic process
EXW40_25070	COG2814	Major facilitator Superfamily
EXW40_25075	COG1733	regulation of RNA biosynthetic process
EXW40_25085	COG1252	NADH dehydrogenase
EXW40_25105	COG0840	transmembrane signaling receptor activity
EXW40_25105	COG3290	protein histidine kinase activity
EXW40_25130	COG3655	Transcriptional regulator
EXW40_25145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW40_25155	COG1733	regulation of RNA biosynthetic process
EXW40_25160	COG0778	Nitroreductase
EXW40_25165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW40_25170	COG4224	UPF0291 protein
EXW40_25175	COG1522	sequence-specific DNA binding
EXW40_25180	COG0288	reversible hydration of carbon dioxide
EXW40_25185	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW40_25190	COG2233	PERMEase
EXW40_25215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW40_25235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW40_25250	COG0557	exoribonuclease II activity
EXW40_25255	COG1647	Serine aminopeptidase, S33
EXW40_25260	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW40_25265	COG1346	cytolysis
EXW40_25280	COG0148	phosphopyruvate hydratase activity
EXW40_25290	COG0149	triose-phosphate isomerase activity
EXW40_25295	COG0126	phosphoglycerate kinase activity
EXW40_25300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW40_25315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW40_25345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW40_25360	COG2323	membrane
EXW40_25370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW40_25375	COG1481	regulation of sporulation
EXW40_25380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW40_25385	COG1660	Displays ATPase and GTPase activities
EXW40_25390	COG1051	belongs to the nudix hydrolase family
EXW40_25400	COG0492	ferredoxin-NADP+ reductase activity
EXW40_25405	COG0457	Tetratricopeptide repeat
EXW40_25410	COG0110	maltose O-acetyltransferase activity
EXW40_25415	COG0546	phosphoglycolate phosphatase activity
EXW40_25420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW40_25425	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW40_25430	COG1950	PFAM Membrane protein of
EXW40_25440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW40_25460	COG0789	Transcriptional regulator
EXW40_25495	COG0583	DNA-binding transcription factor activity
EXW40_25500	COG0789	Transcriptional regulator
EXW40_25505	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW40_25510	COG0488	(ABC) transporter
EXW40_25520	COG1132	(ABC) transporter
EXW40_25525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW40_25530	COG0793	Belongs to the peptidase S41A family
EXW40_25530	COG3409	Peptidoglycan-binding domain 1 protein
EXW40_25535	COG2177	Part of the ABC transporter FtsEX involved in
EXW40_25540	COG2884	Cell division ATP-binding protein ftsE
EXW40_25575	COG1131	(ABC) transporter
EXW40_25610	COG1278	Cold shock
EXW40_25615	COG1040	competence protein
EXW40_25620	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW40_25625	COG1388	LysM domain
EXW40_25625	COG0791	NLP P60 protein
EXW40_25630	COG1733	regulation of RNA biosynthetic process
EXW40_25635	COG1307	EDD domain protein, DegV family
EXW40_25640	COG1739	Uncharacterized protein family UPF0029
EXW40_25645	COG1316	TRANSCRIPTIONal
EXW40_25650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW40_25655	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW40_25660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW40_25670	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW40_25670	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW40_25690	COG1486	melibiose metabolic process
EXW40_25695	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW40_25700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW40_25720	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW40_25730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW40_25735	COG1301	dicarboxylic acid transport
EXW40_25750	COG1511	domain protein
EXW40_25755	COG0583	DNA-binding transcription factor activity
EXW40_25760	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW40_25765	COG1271	oxidase subunit
EXW40_25770	COG1294	oxidase, subunit
EXW40_25775	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW40_25780	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW40_25785	COG1620	l-lactate permease
EXW40_25795	COG2389	metal-binding protein
EXW40_25810	COG1368	sulfuric ester hydrolase activity
EXW40_25820	COG1388	LysM domain
EXW40_25820	COG0791	NLP P60 protein
EXW40_25825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW40_25835	COG1215	transferase activity, transferring glycosyl groups
EXW40_25840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW40_25850	COG3584	3D domain protein
EXW40_25850	COG1388	LysM domain
EXW40_25875	COG4715	Zinc finger, swim domain protein
EXW40_25880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW40_25920	COG0577	efflux transmembrane transporter activity
EXW40_25925	COG1136	(ABC) transporter
EXW40_25960	COG3850	Histidine kinase
EXW40_25960	COG5002	protein histidine kinase activity
EXW40_25965	COG0745	RESPONSE REGULATOR receiver
EXW40_25970	COG1316	TRANSCRIPTIONal
EXW40_25995	COG1134	teichoic acid transport
EXW40_26000	COG1682	transport, permease protein
EXW40_26005	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW40_26030	COG0463	Glycosyl transferase, family 2
EXW40_26030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW40_26045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW40_26050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EXW40_26060	COG1609	Transcriptional regulator
EXW40_26065	COG0726	polysaccharide deacetylase
EXW40_26080	COG0739	heme binding
EXW40_26095	COG3279	Response regulator of the LytR AlgR family
EXW40_26100	COG2385	sporulation resulting in formation of a cellular spore
EXW40_26115	COG4836	Membrane
EXW40_26120	COG1007	ATP synthesis coupled electron transport
EXW40_26125	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW40_26130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW40_26135	COG0713	ATP synthesis coupled electron transport
EXW40_26140	COG0839	Belongs to the complex I subunit 6 family
EXW40_26150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW40_26155	COG0649	NAD binding
EXW40_26160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW40_26165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW40_26170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW40_26175	COG5001	Diguanylate cyclase
EXW40_26175	COG3300	MHYT domain
EXW40_26190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW40_26195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW40_26200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW40_26205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW40_26210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW40_26215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW40_26225	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW40_26250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW40_26260	COG0698	ribose 5-phosphate isomerase
EXW40_26270	COG2190	(PTS) system
EXW40_26275	COG2259	Doxx family
EXW40_26280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW40_26290	COG1971	Probably functions as a manganese efflux pump
EXW40_26295	COG0009	L-threonylcarbamoyladenylate synthase
EXW40_26310	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW40_26315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW40_26320	COG1435	thymidine kinase activity
EXW40_26335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW40_26340	COG1494	fructose-1,6-bisphosphatase
EXW40_26360	COG4821	SIS domain
EXW40_26365	COG0504	CTP synthase activity
EXW40_26370	COG3343	RNA polymerase activity
EXW40_26380	COG1960	acyl-CoA dehydrogenase activity
EXW40_26385	COG1960	acyl-CoA dehydrogenase activity
EXW40_26390	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW40_26395	COG0183	Belongs to the thiolase family
EXW40_26400	COG0247	lactate metabolic process
EXW40_26400	COG2181	nitrate reductase activity
EXW40_26405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW40_26410	COG4294	response to UV
EXW40_26415	COG5001	Diguanylate cyclase
EXW40_26415	COG3300	MHYT domain
EXW40_26430	COG3227	Zinc metalloprotease (Elastase)
EXW40_26435	COG2197	response regulator
EXW40_26440	COG4585	Histidine kinase
EXW40_26445	COG0842	Transport permease protein
EXW40_26450	COG1131	(ABC) transporter
EXW40_26455	COG0024	Methionine aminopeptidase
EXW40_26465	COG2234	aminopeptidase activity
EXW40_26485	COG4506	Protein conserved in bacteria
EXW40_26490	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW40_26510	COG0010	Belongs to the arginase family
EXW40_26515	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW40_26520	COG2814	Major facilitator Superfamily
EXW40_26525	COG0789	Transcriptional regulator
EXW40_26530	COG0584	glycerophosphoryl diester phosphodiesterase
EXW40_26535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW40_26545	COG1994	Peptidase M50
EXW40_26555	COG1078	dGTPase activity
EXW40_26560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW40_26565	COG1120	ATPase activity
EXW40_26570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW40_26575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW40_26580	COG4844	belongs to the
EXW40_26595	COG0280	phosphate acetyltransferase
EXW40_26600	COG3253	May function as heme-dependent peroxidase
EXW40_26610	COG3773	Cell wall hydrolase
EXW40_26620	COG2363	Small membrane protein
EXW40_26635	COG2233	PERMEase
EXW40_26640	COG0561	phosphatase activity
EXW40_26645	COG2814	Major facilitator Superfamily
EXW40_26650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW40_26655	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW40_26660	COG1131	(ABC) transporter
EXW40_26665	COG2755	lipolytic protein G-D-S-L family
EXW40_26670	COG1609	Transcriptional regulator
EXW40_26680	COG0460	homoserine dehydrogenase
EXW40_26685	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW40_26690	COG2873	o-acetylhomoserine
EXW40_26700	COG1011	Hydrolase
EXW40_26705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW40_26715	COG2197	response regulator
EXW40_26720	COG2203	Gaf domain
EXW40_26720	COG4585	Histidine kinase
EXW40_26725	COG0351	phosphomethylpyrimidine kinase
EXW40_26730	COG3706	GGDEF domain
EXW40_26735	COG2879	small protein
EXW40_26740	COG1966	Carbon starvation protein
EXW40_26745	COG3279	Response regulator of the LytR AlgR family
EXW40_26750	COG0477	Major facilitator Superfamily
EXW40_26775	COG0840	transmembrane signaling receptor activity
EXW40_26785	COG1607	acyl-coa hydrolase
EXW40_26790	COG1216	Glycosyl transferase, family 2
EXW40_26800	COG1216	Glycosyl transferase, family 2
EXW40_26810	COG4485	Bacterial membrane protein, YfhO
EXW40_26815	COG0463	Glycosyl transferase, family 2
EXW40_26825	COG1309	transcriptional regulator
EXW40_26830	COG0488	(ABC) transporter
EXW40_26835	COG1309	transcriptional regulator
EXW40_26840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW40_26845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW40_26845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW40_26850	COG0628	permease
EXW40_26860	COG1380	Effector of murein hydrolase LrgA
EXW40_26865	COG3279	Response regulator of the LytR AlgR family
EXW40_26870	COG3275	phosphorelay sensor kinase activity
EXW40_26875	COG2814	Major facilitator Superfamily
EXW40_26880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW40_26885	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW40_26895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW40_26950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW40_26955	COG1272	protein, Hemolysin III
EXW40_26980	COG1164	Oligoendopeptidase f
EXW40_26990	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW40_27000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW40_27005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW40_27010	COG4853	Protein conserved in bacteria
EXW40_27020	COG5002	protein histidine kinase activity
EXW40_27025	COG0745	RESPONSE REGULATOR receiver
EXW40_27055	COG0305	Participates in initiation and elongation during chromosome replication
EXW40_27060	COG0359	binds to the 23S rRNA
EXW40_27065	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW40_27070	COG4241	membrane
EXW40_27080	COG0629	single-stranded DNA binding
EXW40_27085	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW40_27090	COG0012	GTP binding
EXW40_27095	COG4481	Protein conserved in bacteria
EXW40_27100	COG0668	transmembrane transport
EXW40_27110	COG1475	DNA binding
EXW40_27115	COG1192	Involved in chromosome partitioning
EXW40_27120	COG1475	DNA binding
EXW40_27125	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW40_27130	COG0445	tRNA wobble uridine modification
EXW40_27135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW40_27140	COG1847	R3H domain protein
EXW40_27145	COG0706	membrane insertase activity
EXW40_27150	COG0594	ribonuclease P activity
EXW40_27155	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW40_27160	COG1192	Involved in chromosome partitioning
EXW40_27220	COG3409	Peptidoglycan-binding domain 1 protein
EXW40_27285	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW40_27345	COG3620	sequence-specific DNA binding
EXW40_27370	COG1388	LysM domain
EXW40_27370	COG3103	Sh3 type 3 domain protein
EXW40_27370	COG0791	NLP P60 protein
EXW40_27490	COG0484	heat shock protein binding
EXW40_27610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW40_27610	COG0551	DNA topoisomerase type I activity
EXW40_27635	COG1674	ftsk spoiiie
EXW40_27735	COG0741	lytic transglycosylase activity
EXW40_27735	COG0791	NLP P60 protein
EXW40_27860	COG2002	toxin-antitoxin pair type II binding
EXW40_27945	COG0741	lytic transglycosylase activity
EXW40_27960	COG1674	ftsk spoiiie
EXW40_27975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW40_28000	COG5002	protein histidine kinase activity
EXW40_28025	COG0024	Methionine aminopeptidase
EXW40_28055	COG1396	sequence-specific DNA binding
EXW40_28150	COG0791	NLP P60 protein
EXW40_28150	COG0741	lytic transglycosylase activity
EXW40_28160	COG0791	NLP P60 protein
EXW40_28160	COG3883	PFAM NLP P60 protein
EXW40_28230	COG2002	toxin-antitoxin pair type II binding
EXW40_28240	COG1923	regulation of RNA biosynthetic process
EXW40_28260	COG0582	viral genome integration into host DNA
EXW40_28275	COG2732	(Barnase) inhibitor
EXW40_28350	COG0662	Cupin 2, conserved barrel domain protein
EXW40_28360	COG1923	regulation of RNA biosynthetic process
EXW40_28385	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW40_28415	COG0745	RESPONSE REGULATOR receiver
EXW40_28450	COG0833	amino acid
EXW40_28455	COG1285	pathogenesis
EXW40_28460	COG2267	carboxylic ester hydrolase activity
EXW40_28465	COG1073	alpha beta
EXW40_28470	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW40_28475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW40_28480	COG0772	Belongs to the SEDS family
EXW40_28485	COG2239	Acts as a magnesium transporter
EXW40_28495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW40_28510	COG4974	Belongs to the 'phage' integrase family
EXW40_28540	COG2508	Transcriptional regulator
EXW40_28540	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW40_28545	COG0697	spore germination
EXW40_28555	COG0697	spore germination
EXW40_28575	COG0697	spore germination
EXW40_28580	COG3858	chitin binding
EXW40_28590	COG1309	transcriptional regulator
EXW40_28615	COG1136	(ABC) transporter
EXW40_28640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW40_28640	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW40_28655	COG0577	efflux transmembrane transporter activity
EXW40_28660	COG1136	(ABC) transporter
EXW40_28675	COG2205	protein histidine kinase activity
EXW40_28680	COG0745	RESPONSE REGULATOR receiver
EXW40_28695	COG1725	Transcriptional regulator
EXW40_28700	COG1131	(ABC) transporter
EXW40_28740	COG1329	Transcriptional regulator
EXW40_28760	COG3344	reverse transcriptase
EXW40_28805	COG4176	ABC-type proline glycine betaine transport system permease component
EXW40_28810	COG4175	Glycine betaine
EXW40_28810	COG0517	IMP dehydrogenase activity
EXW40_28830	COG1982	Orn Lys Arg decarboxylase major
EXW40_28840	COG0833	amino acid
EXW40_28845	COG0450	alkyl hydroperoxide reductase
EXW40_28885	COG1136	(ABC) transporter
EXW40_28905	COG4974	Belongs to the 'phage' integrase family
EXW40_28925	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW40_28930	COG0840	transmembrane signaling receptor activity
EXW40_28950	COG1396	sequence-specific DNA binding
EXW40_29000	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXW40_29015	COG2002	toxin-antitoxin pair type II binding
EXW40_29100	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EXW40_29125	COG2814	Major facilitator Superfamily
EXW40_29180	COG1923	regulation of RNA biosynthetic process
EXW40_29190	COG2002	toxin-antitoxin pair type II binding
EXW40_29195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW40_29195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW40_29200	COG1252	NADH dehydrogenase
EXW40_29215	COG0697	spore germination
EXW40_29245	COG2239	Acts as a magnesium transporter
EXW40_29255	COG2755	lipolytic protein G-D-S-L family
EXW40_29255	COG0657	acetylesterase activity
EXW40_29275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW40_29285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW40_29355	COG1846	Transcriptional regulator
EXW40_29395	COG4641	Protein conserved in bacteria
EXW40_29400	COG2089	acid synthase
EXW40_29415	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW40_29420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW40_29425	COG1088	dTDP-glucose 4,6-dehydratase activity
EXW40_29430	COG1086	Polysaccharide biosynthesis protein
EXW40_29435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW40_29440	COG0463	Glycosyl transferase, family 2
EXW40_29520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW40_29610	COG2140	Oxalate decarboxylase
EXW40_29630	COG0024	Methionine aminopeptidase
EXW40_29635	COG1923	regulation of RNA biosynthetic process
EXW40_29645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW40_29660	COG0776	regulation of translation
EXW40_29665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW40_29670	COG0367	asparagine synthase
EXW40_29695	COG0542	response to heat
EXW40_29705	COG3397	chitin binding
EXW40_29795	COG1404	Belongs to the peptidase S8 family
EXW40_29815	COG2814	Major facilitator Superfamily
EXW40_29820	COG2234	aminopeptidase activity
EXW40_29830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW40_29845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW40_29850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW40_29855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW40_29865	COG0456	acetyltransferase
EXW40_29900	COG3409	Peptidoglycan-binding domain 1 protein
EXW40_29910	COG0582	viral genome integration into host DNA