locus-tag	class	description
EXW49_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW49_00010	COG0592	DNA-directed DNA polymerase activity
EXW49_00015	COG2501	S4 domain
EXW49_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW49_00025	COG0187	DNA topoisomerase II activity
EXW49_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW49_00065	COG0517	IMP dehydrogenase activity
EXW49_00065	COG0516	GMP reductase activity
EXW49_00070	COG1686	Belongs to the peptidase S11 family
EXW49_00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW49_00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW49_00100	COG1428	Deoxynucleoside kinase
EXW49_00105	COG1428	Deoxynucleoside kinase
EXW49_00110	COG1335	isochorismatase
EXW49_00115	COG0590	tRNA wobble adenosine to inosine editing
EXW49_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW49_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW49_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW49_00180	COG1982	Orn Lys Arg decarboxylase major
EXW49_00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW49_00190	COG0470	DNA polymerase III
EXW49_00195	COG1774	PSP1 C-terminal conserved region
EXW49_00200	COG4467	Involved in initiation control of chromosome replication
EXW49_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW49_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW49_00220	COG2002	toxin-antitoxin pair type II binding
EXW49_00230	COG0084	hydrolase, TatD family'
EXW49_00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW49_00250	COG4466	Protein conserved in bacteria
EXW49_00260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW49_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW49_00270	COG0251	oxidation-reduction process
EXW49_00275	COG2088	sporulation resulting in formation of a cellular spore
EXW49_00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW49_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW49_00305	COG2002	toxin-antitoxin pair type II binding
EXW49_00310	COG2244	polysaccharide biosynthetic process
EXW49_00315	COG3956	TIGRFAM MazG family protein
EXW49_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW49_00340	COG1098	S1 RNA binding domain
EXW49_00355	COG2208	phosphoserine phosphatase activity
EXW49_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW49_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW49_00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW49_00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW49_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW49_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW49_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW49_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW49_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW49_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW49_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW49_00420	COG1396	sequence-specific DNA binding
EXW49_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW49_00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW49_00520	COG3880	PFAM UvrB UvrC protein
EXW49_00525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW49_00530	COG0542	response to heat
EXW49_00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW49_00540	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW49_00545	COG4956	integral membrane protein (PIN domain superfamily)
EXW49_00550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW49_00560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW49_00565	COG1045	serine acetyltransferase
EXW49_00570	COG0215	cysteine-tRNA ligase activity
EXW49_00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW49_00585	COG3688	RNA-binding protein containing a PIN domain
EXW49_00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW49_00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW49_00605	COG0250	Participates in transcription elongation, termination and antitermination
EXW49_00610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW49_00615	COG0081	regulation of translation
EXW49_00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW49_00625	COG0222	ribosome binding
EXW49_00630	COG2813	Specifically methylates the guanine in position
EXW49_00635	COG0085	RNA polymerase activity
EXW49_00640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW49_00645	COG1358	cellular component organization or biogenesis
EXW49_00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW49_00655	COG0049	tRNA binding
EXW49_00660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW49_00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW49_00670	COG0051	transcription antitermination factor activity, RNA binding
EXW49_00675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW49_00680	COG0088	Forms part of the polypeptide exit tunnel
EXW49_00685	COG0089	rRNA binding
EXW49_00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW49_00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW49_00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW49_00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EXW49_00715	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW49_00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW49_00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EXW49_00730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW49_00735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW49_00745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW49_00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW49_00765	COG1841	ribosomal large subunit assembly
EXW49_00770	COG0200	Binds to the 23S rRNA
EXW49_00775	COG0201	protein transport
EXW49_00780	COG0563	adenylate kinase activity
EXW49_00785	COG0024	Methionine aminopeptidase
EXW49_00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW49_00800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW49_00805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW49_00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW49_00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW49_00845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW49_00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_00860	COG0489	protein tyrosine kinase activity
EXW49_00870	COG2194	sulfuric ester hydrolase activity
EXW49_00875	COG0726	polysaccharide deacetylase
EXW49_00955	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW49_00960	COG4856	YbbR-like protein
EXW49_00965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW49_00980	COG4946	Tricorn protease homolog
EXW49_00980	COG1506	peptidase
EXW49_00980	COG0823	Involved in the tonB-independent uptake of proteins
EXW49_00990	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_00995	COG2011	ABC-type metal ion transport system permease component
EXW49_01005	COG1464	Belongs to the NlpA lipoprotein family
EXW49_01010	COG0604	alcohol dehydrogenase
EXW49_01020	COG0277	FAD linked oxidase domain protein
EXW49_01025	COG2271	Major facilitator Superfamily
EXW49_01035	COG2814	Major facilitator Superfamily
EXW49_01050	COG0601	transmembrane transport
EXW49_01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW49_01060	COG0444	Belongs to the ABC transporter superfamily
EXW49_01065	COG4608	Belongs to the ABC transporter superfamily
EXW49_01070	COG4166	transmembrane transport
EXW49_01080	COG2207	Transcriptional regulator
EXW49_01095	COG4166	transmembrane transport
EXW49_01100	COG4166	transmembrane transport
EXW49_01105	COG0656	L-ascorbic acid biosynthetic process
EXW49_01110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW49_01125	COG4149	molybdate abc transporter
EXW49_01130	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW49_01135	COG1910	domain protein
EXW49_01150	COG0697	spore germination
EXW49_01165	COG0204	Acyl-transferase
EXW49_01175	COG1609	Transcriptional regulator
EXW49_01185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_01200	COG5298	Protein conserved in bacteria
EXW49_01225	COG0488	(ABC) transporter
EXW49_01230	COG4585	Histidine kinase
EXW49_01235	COG2197	response regulator
EXW49_01240	COG1131	(ABC) transporter
EXW49_01245	COG0842	Transport permease protein
EXW49_01245	COG1511	domain protein
EXW49_01250	COG0842	Transport permease protein
EXW49_01265	COG0601	transmembrane transport
EXW49_01270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW49_01275	COG0444	Belongs to the ABC transporter superfamily
EXW49_01280	COG4608	Belongs to the ABC transporter superfamily
EXW49_01285	COG0561	phosphatase activity
EXW49_01315	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW49_01320	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW49_01330	COG2814	Major facilitator Superfamily
EXW49_01340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW49_01350	COG4294	response to UV
EXW49_01355	COG0705	Rhomboid family
EXW49_01360	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW49_01365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW49_01370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW49_01375	COG0864	Transcriptional regulator
EXW49_01380	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW49_01385	COG2183	response to ionizing radiation
EXW49_01485	COG0802	atpase or kinase
EXW49_01490	COG1214	PFAM Peptidase M22, glycoprotease
EXW49_01495	COG0456	acetyltransferase
EXW49_01505	COG0488	(ABC) transporter
EXW49_01510	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW49_01520	COG1266	CAAX protease self-immunity
EXW49_01525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW49_01530	COG0459	protein refolding
EXW49_01535	COG0519	Catalyzes the synthesis of GMP from XMP
EXW49_01535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW49_01585	COG2252	PERMEase
EXW49_01595	COG5002	protein histidine kinase activity
EXW49_01620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW49_01650	COG2226	methyltransferase
EXW49_01660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW49_01670	COG1215	transferase activity, transferring glycosyl groups
EXW49_01695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_01700	COG0506	proline dehydrogenase activity
EXW49_01725	COG0697	spore germination
EXW49_01750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW49_01755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW49_01760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW49_01765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW49_01770	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW49_01775	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW49_01780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW49_01785	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW49_01790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW49_01795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW49_01800	COG0138	bifunctional purine biosynthesis protein purh
EXW49_01805	COG0151	Belongs to the GarS family
EXW49_01825	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW49_01830	COG0210	DNA helicase
EXW49_01835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW49_01840	COG4851	CamS sex pheromone cAM373 precursor
EXW49_01850	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_01855	COG1335	isochorismatase
EXW49_01865	COG2011	ABC-type metal ion transport system permease component
EXW49_01870	COG1464	Belongs to the NlpA lipoprotein family
EXW49_01885	COG0003	Pfam Anion-transporting ATPase
EXW49_01890	COG1846	Transcriptional regulator
EXW49_01895	COG4682	membrane
EXW49_01905	COG0154	amidase activity
EXW49_01910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW49_01915	COG1597	lipid kinase activity
EXW49_01920	COG0546	phosphoglycolate phosphatase activity
EXW49_01925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW49_01935	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_01940	COG2076	Multidrug Resistance protein
EXW49_01945	COG2309	aminopeptidase activity
EXW49_01960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_01970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW49_01975	COG5002	protein histidine kinase activity
EXW49_01980	COG4807	Protein conserved in bacteria
EXW49_02005	COG1757	Na H antiporter
EXW49_02010	COG1473	amidohydrolase
EXW49_02025	COG0450	alkyl hydroperoxide reductase
EXW49_02035	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW49_02045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_02050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_02055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_02065	COG0492	ferredoxin-NADP+ reductase activity
EXW49_02080	COG0166	Belongs to the GPI family
EXW49_02125	COG3541	Predicted nucleotidyltransferase
EXW49_02130	COG2814	Major facilitator Superfamily
EXW49_02135	COG0723	plastoquinol--plastocyanin reductase activity
EXW49_02135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW49_02145	COG0765	amino acid transport
EXW49_02150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_02160	COG0840	transmembrane signaling receptor activity
EXW49_02185	COG0549	Belongs to the carbamate kinase family
EXW49_02200	COG0277	FAD linked oxidase domain protein
EXW49_02205	COG0366	Alpha amylase catalytic
EXW49_02210	COG1263	PTS System
EXW49_02210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW49_02210	COG2190	(PTS) system
EXW49_02230	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW49_02235	COG0352	thiamine-phosphate diphosphorylase activity
EXW49_02240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW49_02255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW49_02260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW49_02265	COG1116	anion transmembrane transporter activity
EXW49_02270	COG0488	(ABC) transporter
EXW49_02305	COG2270	Major facilitator Superfamily
EXW49_02335	COG2310	stress, protein
EXW49_02340	COG2310	stress, protein
EXW49_02345	COG2310	stress, protein
EXW49_02350	COG0861	Integral membrane protein TerC family
EXW49_02360	COG3853	Toxic anion resistance protein (TelA)
EXW49_02370	COG4840	Belongs to the UPF0435 family
EXW49_02375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW49_02385	COG1295	ribonuclease BN
EXW49_02390	COG2217	Heavy metal translocating P-type atpase
EXW49_02395	COG0697	spore germination
EXW49_02415	COG0586	Pfam SNARE associated Golgi protein
EXW49_02430	COG3871	stress protein (general stress protein 26)
EXW49_02435	COG0387	Pfam Sodium calcium exchanger
EXW49_02445	COG0535	radical SAM domain protein
EXW49_02465	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW49_02485	COG3829	transcription factor binding
EXW49_02495	COG0833	amino acid
EXW49_02500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW49_02520	COG2066	Belongs to the glutaminase family
EXW49_02530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW49_02530	COG1263	PTS System
EXW49_02535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_02550	COG1216	Glycosyl transferase, family 2
EXW49_02560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW49_02560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW49_02565	COG0463	Glycosyl transferase, family 2
EXW49_02580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW49_02585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW49_02600	COG1228	amidohydrolase
EXW49_02605	COG1090	epimerase
EXW49_02610	COG2137	regulation of response to DNA damage stimulus
EXW49_02635	COG1988	membrane-bound metal-dependent
EXW49_02640	COG1194	a g-specific adenine glycosylase
EXW49_02660	COG3557	Belongs to the UPF0374 family
EXW49_02665	COG1132	(ABC) transporter
EXW49_02670	COG4129	membrane
EXW49_02675	COG0067	glutamate synthase
EXW49_02675	COG0069	glutamate synthase activity
EXW49_02675	COG0070	glutamate synthase
EXW49_02680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW49_02685	COG4555	ABC transporter
EXW49_02705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW49_02710	COG0735	belongs to the Fur family
EXW49_02830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW49_02835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW49_02855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW49_02860	COG5001	Diguanylate cyclase
EXW49_02860	COG1716	ATPase activity
EXW49_02865	COG2766	serine protein kinase
EXW49_02870	COG2718	Belongs to the UPF0229 family
EXW49_02885	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW49_02890	COG2268	Band 7 protein
EXW49_02900	COG3290	protein histidine kinase activity
EXW49_02905	COG4565	transcriptional regulatory protein
EXW49_02910	COG2851	Citrate transporter
EXW49_02935	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW49_02940	COG3842	ATPase activity
EXW49_02945	COG1175	transmembrane transport
EXW49_02950	COG0395	ABC-type sugar transport system, permease component
EXW49_02960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW49_02965	COG0745	RESPONSE REGULATOR receiver
EXW49_02970	COG5002	protein histidine kinase activity
EXW49_02980	COG4990	cell redox homeostasis
EXW49_02990	COG3290	protein histidine kinase activity
EXW49_02995	COG4565	transcriptional regulatory protein
EXW49_03000	COG3493	citrate carrier protein
EXW49_03005	COG0281	malic enzyme
EXW49_03015	COG0697	spore germination
EXW49_03020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_03030	COG5002	protein histidine kinase activity
EXW49_03035	COG0745	RESPONSE REGULATOR receiver
EXW49_03040	COG0456	acetyltransferase
EXW49_03045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW49_03050	COG3383	formate dehydrogenase (NAD+) activity
EXW49_03055	COG2427	Protein of unknown function (DUF1641)
EXW49_03070	COG0531	amino acid
EXW49_03085	COG0640	Transcriptional regulator
EXW49_03090	COG2217	Heavy metal translocating P-type atpase
EXW49_03095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW49_03105	COG3227	Zinc metalloprotease (Elastase)
EXW49_03125	COG2720	vancomycin resistance protein
EXW49_03130	COG1316	TRANSCRIPTIONal
EXW49_03135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_03140	COG0346	lactoylglutathione lyase activity
EXW49_03145	COG1253	flavin adenine dinucleotide binding
EXW49_03150	COG1027	Aspartate ammonia-lyase
EXW49_03155	COG1620	l-lactate permease
EXW49_03160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_03180	COG3104	oligopeptide transport
EXW49_03185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_03190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_03195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_03210	COG0156	8-amino-7-oxononanoate synthase activity
EXW49_03215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW49_03225	COG4548	von Willebrand factor, type A
EXW49_03230	COG0714	Associated with various cellular activities
EXW49_03255	COG2801	Transposase and inactivated derivatives
EXW49_03260	COG0531	amino acid
EXW49_03265	COG2188	Transcriptional regulator
EXW49_03270	COG1263	PTS System
EXW49_03270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW49_03275	COG0366	Alpha amylase catalytic
EXW49_03290	COG0697	spore germination
EXW49_03295	COG4585	Histidine kinase
EXW49_03300	COG2197	response regulator
EXW49_03305	COG1404	Belongs to the peptidase S8 family
EXW49_03320	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW49_03325	COG1115	amino acid carrier protein
EXW49_03335	COG1126	abc transporter atp-binding protein
EXW49_03340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_03345	COG0765	amino acid transport
EXW49_03350	COG0765	amino acid transport
EXW49_03355	COG0833	amino acid
EXW49_03385	COG2378	regulation of single-species biofilm formation
EXW49_03390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW49_03395	COG5002	protein histidine kinase activity
EXW49_03410	COG0659	secondary active sulfate transmembrane transporter activity
EXW49_03435	COG0601	transmembrane transport
EXW49_03440	COG4608	Belongs to the ABC transporter superfamily
EXW49_03450	COG2271	Major facilitator Superfamily
EXW49_03455	COG1846	Transcriptional regulator
EXW49_03460	COG0477	Major facilitator Superfamily
EXW49_03465	COG1609	Transcriptional regulator
EXW49_03470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW49_03475	COG1869	D-ribose catabolic process
EXW49_03485	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW49_03490	COG1879	ABC-type sugar transport system periplasmic component
EXW49_03510	COG1063	alcohol dehydrogenase
EXW49_03555	COG0840	transmembrane signaling receptor activity
EXW49_03560	COG3583	domain protein
EXW49_03560	COG3584	3D domain protein
EXW49_03565	COG1476	TRANSCRIPTIONal
EXW49_03585	COG3104	oligopeptide transport
EXW49_03590	COG1114	Component of the transport system for branched-chain amino acids
EXW49_03605	COG1113	amino acid transport
EXW49_03610	COG2252	PERMEase
EXW49_03625	COG2153	protein acetylation
EXW49_03635	COG0475	glutathione-regulated potassium exporter activity
EXW49_03635	COG0569	domain protein
EXW49_03645	COG1845	cytochrome c oxidase, subunit III
EXW49_03650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW49_03660	COG0833	amino acid
EXW49_03665	COG4990	cell redox homeostasis
EXW49_03680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW49_03685	COG0697	spore germination
EXW49_03690	COG0531	amino acid
EXW49_03700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW49_03705	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW49_03715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW49_03720	COG0573	inorganic phosphate transmembrane transporter activity
EXW49_03725	COG0581	inorganic phosphate transmembrane transporter activity
EXW49_03735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW49_03855	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW49_03870	COG4991	sh3 domain protein
EXW49_03870	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_03870	COG3103	Sh3 type 3 domain protein
EXW49_03875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW49_03880	COG1116	anion transmembrane transporter activity
EXW49_03885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW49_03890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW49_03895	COG0352	thiamine-phosphate diphosphorylase activity
EXW49_03900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW49_03905	COG2104	thiamine diphosphate biosynthetic process
EXW49_03915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW49_03920	COG0351	phosphomethylpyrimidine kinase
EXW49_03950	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW49_03955	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW49_03960	COG2205	protein histidine kinase activity
EXW49_03965	COG2814	Major facilitator Superfamily
EXW49_03970	COG1846	Transcriptional regulator
EXW49_03990	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW49_03995	COG1129	ABC transporter
EXW49_04000	COG1879	ABC-type sugar transport system periplasmic component
EXW49_04005	COG2252	PERMEase
EXW49_04010	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_04070	COG0778	Nitroreductase
EXW49_04075	COG2719	SpoVR family
EXW49_04095	COG1937	Protein conserved in bacteria
EXW49_04100	COG0425	Belongs to the sulfur carrier protein TusA family
EXW49_04100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_04105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_04105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_04110	COG0425	Belongs to the sulfur carrier protein TusA family
EXW49_04115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_04115	COG0425	Belongs to the sulfur carrier protein TusA family
EXW49_04120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_04125	COG2210	Belongs to the sulfur carrier protein TusA family
EXW49_04130	COG0730	response to heat
EXW49_04140	COG1316	TRANSCRIPTIONal
EXW49_04145	COG0604	alcohol dehydrogenase
EXW49_04150	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW49_04160	COG2814	Major facilitator Superfamily
EXW49_04175	COG3711	transcriptional antiterminator
EXW49_04175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW49_04180	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW49_04185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW49_04205	COG3584	3D domain protein
EXW49_04205	COG1388	LysM domain
EXW49_04210	COG0577	efflux transmembrane transporter activity
EXW49_04215	COG1136	(ABC) transporter
EXW49_04225	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW49_04240	COG0577	efflux transmembrane transporter activity
EXW49_04245	COG1114	Component of the transport system for branched-chain amino acids
EXW49_04250	COG3546	catalase activity
EXW49_04275	COG0586	Pfam SNARE associated Golgi protein
EXW49_04305	COG0531	amino acid
EXW49_04310	COG0475	glutathione-regulated potassium exporter activity
EXW49_04320	COG1737	Transcriptional regulator
EXW49_04325	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW49_04330	COG1263	PTS System
EXW49_04330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW49_04340	COG2259	Doxx family
EXW49_04360	COG0697	spore germination
EXW49_04365	COG1522	sequence-specific DNA binding
EXW49_04375	COG0300	oxidoreductase activity
EXW49_04390	COG2076	Multidrug Resistance protein
EXW49_04395	COG1309	transcriptional regulator
EXW49_04400	COG2814	Major facilitator Superfamily
EXW49_04405	COG1733	regulation of RNA biosynthetic process
EXW49_04420	COG4533	DNA binding
EXW49_04425	COG2211	Major facilitator Superfamily
EXW49_04440	COG0531	amino acid
EXW49_04445	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_04460	COG1132	(ABC) transporter
EXW49_04465	COG1132	(ABC) transporter
EXW49_04470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_04475	COG0765	amino acid transport
EXW49_04480	COG1126	abc transporter atp-binding protein
EXW49_04495	COG0189	ligase activity
EXW49_04505	COG4399	Belongs to the UPF0754 family
EXW49_04510	COG3679	Belongs to the UPF0342 family
EXW49_04525	COG0028	Belongs to the TPP enzyme family
EXW49_04530	COG3527	Alpha-acetolactate decarboxylase
EXW49_04535	COG0463	Glycosyl transferase, family 2
EXW49_04540	COG1216	Glycosyl transferase, family 2
EXW49_04545	COG2094	Belongs to the DNA glycosylase MPG family
EXW49_04550	COG0561	phosphatase activity
EXW49_04555	COG3409	Peptidoglycan-binding domain 1 protein
EXW49_04555	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW49_04560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW49_04565	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_04570	COG0586	Pfam SNARE associated Golgi protein
EXW49_04580	COG4978	Transcriptional regulator
EXW49_04580	COG0789	Transcriptional regulator
EXW49_04590	COG0659	secondary active sulfate transmembrane transporter activity
EXW49_04605	COG0653	protein targeting
EXW49_04610	COG2244	polysaccharide biosynthetic process
EXW49_04620	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_04625	COG4196	transglutaminase domain protein
EXW49_04640	COG1696	Membrane protein involved in D-alanine export
EXW49_04655	COG1024	Enoyl-CoA hydratase
EXW49_04670	COG1363	Peptidase, m42
EXW49_04685	COG2318	DinB family
EXW49_04705	COG0579	oxidoreductase
EXW49_04740	COG0601	transmembrane transport
EXW49_04745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW49_04750	COG0444	Belongs to the ABC transporter superfamily
EXW49_04755	COG4608	Belongs to the ABC transporter superfamily
EXW49_04855	COG0477	Major facilitator Superfamily
EXW49_04860	COG3290	protein histidine kinase activity
EXW49_04865	COG4565	transcriptional regulatory protein
EXW49_04870	COG3181	Tripartite tricarboxylate transporter family receptor
EXW49_04875	COG0494	nUDIX hydrolase
EXW49_04920	COG0305	Participates in initiation and elongation during chromosome replication
EXW49_04945	COG0477	Major facilitator Superfamily
EXW49_05040	COG2732	(Barnase) inhibitor
EXW49_05045	COG2814	Major facilitator Superfamily
EXW49_05050	COG0640	Transcriptional regulator
EXW49_05090	COG2376	Dihydroxyacetone kinase
EXW49_05110	COG2376	Dihydroxyacetone kinase
EXW49_05120	COG2720	vancomycin resistance protein
EXW49_05170	COG1846	Transcriptional regulator
EXW49_05175	COG0825	malonyl-CoA metabolic process
EXW49_05200	COG2807	transmembrane transport
EXW49_05215	COG4585	Histidine kinase
EXW49_05220	COG2197	response regulator
EXW49_05250	COG0420	3'-5' exonuclease activity
EXW49_05255	COG4717	serine-type aminopeptidase activity
EXW49_05260	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW49_05265	COG0346	lactoylglutathione lyase activity
EXW49_05270	COG0457	Tetratricopeptide repeat
EXW49_05280	COG2267	carboxylic ester hydrolase activity
EXW49_05295	COG3620	sequence-specific DNA binding
EXW49_05300	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW49_05305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW49_05310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW49_05315	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW49_05320	COG1595	DNA-templated transcription, initiation
EXW49_05340	COG3973	AAA domain
EXW49_05345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW49_05370	COG0537	adenosine 5'-monophosphoramidase activity
EXW49_05375	COG1131	(ABC) transporter
EXW49_05380	COG4473	ABC transporter
EXW49_05390	COG0247	lactate metabolic process
EXW49_05395	COG1139	Iron-sulfur cluster binding protein
EXW49_05400	COG1556	Lactate utilization protein
EXW49_05430	COG3402	PFAM membrane-flanked domain
EXW49_05435	COG3428	Bacterial PH domain
EXW49_05475	COG3402	PFAM membrane-flanked domain
EXW49_05480	COG3428	Bacterial PH domain
EXW49_05490	COG2329	Antibiotic biosynthesis monooxygenase
EXW49_05495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW49_05500	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW49_05505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW49_05510	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW49_05530	COG1309	transcriptional regulator
EXW49_05580	COG1609	Transcriptional regulator
EXW49_05590	COG1234	tRNA 3'-trailer cleavage
EXW49_05595	COG0095	Lipoate-protein ligase
EXW49_05605	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_05620	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW49_05630	COG4208	sulfate ABC transporter
EXW49_05645	COG1408	metallophosphoesterase
EXW49_05650	COG1078	dGTPase activity
EXW49_05665	COG1595	DNA-templated transcription, initiation
EXW49_05675	COG2207	Transcriptional regulator
EXW49_05675	COG3708	Transcriptional regulator
EXW49_05680	COG2205	protein histidine kinase activity
EXW49_05685	COG0745	RESPONSE REGULATOR receiver
EXW49_05710	COG0501	Belongs to the peptidase M48B family
EXW49_05715	COG0840	transmembrane signaling receptor activity
EXW49_05720	COG0697	spore germination
EXW49_05750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW49_05755	COG2224	Isocitrate lyase
EXW49_05765	COG1278	Cold shock
EXW49_05780	COG4903	ComK protein
EXW49_05790	COG0398	Pfam SNARE associated Golgi protein
EXW49_05800	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW49_05805	COG1074	ATP-dependent DNA helicase activity
EXW49_05855	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW49_05880	COG0367	asparagine synthase
EXW49_05890	COG0753	catalase activity
EXW49_05895	COG0004	ammonium transporteR
EXW49_05905	COG1666	GTP binding
EXW49_05910	COG2996	Protein conserved in bacteria
EXW49_05920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW49_05930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_05945	COG0561	phosphatase activity
EXW49_05965	COG2267	carboxylic ester hydrolase activity
EXW49_05980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW49_05985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW49_05990	COG5504	Zn-dependent protease
EXW49_06005	COG0180	Tryptophanyl-tRNA synthetase
EXW49_06020	COG4166	transmembrane transport
EXW49_06025	COG0601	transmembrane transport
EXW49_06030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW49_06035	COG0444	Belongs to the ABC transporter superfamily
EXW49_06040	COG4608	Belongs to the ABC transporter superfamily
EXW49_06045	COG0534	Mate efflux family protein
EXW49_06050	COG4166	transmembrane transport
EXW49_06070	COG0861	Integral membrane protein TerC family
EXW49_06075	COG4862	establishment of competence for transformation
EXW49_06080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW49_06090	COG1164	Oligoendopeptidase f
EXW49_06100	COG2346	COG2346, Truncated hemoglobins
EXW49_06105	COG4116	CYTH
EXW49_06115	COG2357	RelA SpoT domain protein
EXW49_06125	COG0564	pseudouridine synthase activity
EXW49_06135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW49_06140	COG0772	Belongs to the SEDS family
EXW49_06145	COG1216	Glycosyl transferase, family 2
EXW49_06165	COG0457	Tetratricopeptide repeat
EXW49_06165	COG0463	Glycosyl transferase, family 2
EXW49_06185	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW49_06200	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW49_06245	COG2153	protein acetylation
EXW49_06250	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW49_06255	COG2382	esterase
EXW49_06280	COG5492	domain, Protein
EXW49_06285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW49_06300	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW49_06300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW49_06305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW49_06310	COG0134	indole-3-glycerol-phosphate synthase activity
EXW49_06315	COG0135	phosphoribosylanthranilate isomerase activity
EXW49_06320	COG0133	tryptophan synthase activity
EXW49_06325	COG0159	tryptophan synthase activity
EXW49_06335	COG1620	l-lactate permease
EXW49_06345	COG5634	Uncharacterized conserved protein (DUF2278)
EXW49_06430	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW49_06435	COG0567	Dehydrogenase, E1 component
EXW49_06440	COG1476	TRANSCRIPTIONal
EXW49_06465	COG4152	abc transporter atp-binding protein
EXW49_06470	COG1668	transmembrane transport
EXW49_06490	COG1686	Belongs to the peptidase S11 family
EXW49_06495	COG0681	Belongs to the peptidase S26 family
EXW49_06505	COG2801	Transposase and inactivated derivatives
EXW49_06540	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_06550	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW49_06555	COG1177	transmembrane transport
EXW49_06560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW49_06570	COG2409	Drug exporters of the RND superfamily
EXW49_06580	COG0564	pseudouridine synthase activity
EXW49_06590	COG2340	Cysteine-rich secretory protein family
EXW49_06595	COG0247	lactate metabolic process
EXW49_06600	COG0277	FAD linked oxidase domain protein
EXW49_06605	COG3835	regulator
EXW49_06615	COG0745	RESPONSE REGULATOR receiver
EXW49_06620	COG5002	protein histidine kinase activity
EXW49_06625	COG2186	Transcriptional regulator
EXW49_06630	COG0247	lactate metabolic process
EXW49_06635	COG1139	Iron-sulfur cluster binding protein
EXW49_06640	COG1556	Lactate utilization protein
EXW49_06645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW49_06655	COG2116	formate transmembrane transporter activity
EXW49_06660	COG0861	Integral membrane protein TerC family
EXW49_06665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW49_06675	COG2030	dehydratase
EXW49_06695	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_06700	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW49_06710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW49_06725	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW49_06730	COG3842	ATPase activity
EXW49_06740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW49_06745	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW49_06755	COG1349	DNA-binding transcription factor activity
EXW49_06765	COG0235	Class ii aldolase
EXW49_06775	COG2861	carbohydrate metabolic process
EXW49_06785	COG3852	Histidine kinase
EXW49_06790	COG1846	Transcriptional regulator
EXW49_06800	COG2318	DinB family
EXW49_06805	COG5002	protein histidine kinase activity
EXW49_06810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW49_06815	COG0720	synthase
EXW49_06825	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW49_06830	COG4873	Protein conserved in bacteria
EXW49_06845	COG2801	Transposase and inactivated derivatives
EXW49_06850	COG0456	acetyltransferase
EXW49_06870	COG1780	Probably involved in ribonucleotide reductase function
EXW49_06885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW49_06890	COG0531	amino acid
EXW49_06900	COG3829	transcription factor binding
EXW49_06900	COG3290	protein histidine kinase activity
EXW49_06905	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_06915	COG1725	Transcriptional regulator
EXW49_06920	COG1131	(ABC) transporter
EXW49_06930	COG1131	(ABC) transporter
EXW49_06935	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW49_06940	COG1266	CAAX protease self-immunity
EXW49_06950	COG1522	sequence-specific DNA binding
EXW49_06960	COG1335	isochorismatase
EXW49_06970	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW49_06975	COG2070	2-Nitropropane dioxygenase
EXW49_06980	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW49_06985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW49_06990	COG1696	Membrane protein involved in D-alanine export
EXW49_06995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW49_07010	COG0716	FMN binding
EXW49_07035	COG0534	Mate efflux family protein
EXW49_07040	COG1968	undecaprenyl-diphosphatase activity
EXW49_07060	COG1846	Transcriptional regulator
EXW49_07070	COG1301	dicarboxylic acid transport
EXW49_07075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW49_07085	COG3874	Sporulation protein YtfJ
EXW49_07105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW49_07110	COG0028	Belongs to the TPP enzyme family
EXW49_07115	COG0440	acetolactate synthase activity
EXW49_07125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW49_07135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW49_07145	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW49_07150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW49_07160	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW49_07165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW49_07170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW49_07175	COG0107	imidazoleglycerol-phosphate synthase activity
EXW49_07185	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW49_07190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW49_07205	COG1183	phosphatidylcholine synthase activity
EXW49_07210	COG1368	sulfuric ester hydrolase activity
EXW49_07220	COG0019	diaminopimelate decarboxylase activity
EXW49_07230	COG0175	sulfate reduction
EXW49_07235	COG2046	Belongs to the sulfate adenylyltransferase family
EXW49_07240	COG0529	Catalyzes the synthesis of activated sulfate
EXW49_07245	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW49_07265	COG1648	precorrin-2 dehydrogenase activity
EXW49_07270	COG0733	neurotransmitter:sodium symporter activity
EXW49_07290	COG1757	Na H antiporter
EXW49_07310	COG4758	membrane
EXW49_07315	COG4585	Histidine kinase
EXW49_07320	COG2197	response regulator
EXW49_07330	COG1114	Component of the transport system for branched-chain amino acids
EXW49_07340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW49_07385	COG0730	response to heat
EXW49_07390	COG0306	phosphate transporter
EXW49_07395	COG1392	Phosphate transport regulator
EXW49_07400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW49_07415	COG3852	Histidine kinase
EXW49_07420	COG1801	Protein of unknown function DUF72
EXW49_07430	COG0582	viral genome integration into host DNA
EXW49_07435	COG5002	protein histidine kinase activity
EXW49_07450	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW49_07450	COG0392	lysyltransferase activity
EXW49_07465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW49_07470	COG1686	Belongs to the peptidase S11 family
EXW49_07475	COG2715	membrane protein required for spore maturation
EXW49_07480	COG0700	Nucleoside recognition
EXW49_07485	COG1187	pseudouridine synthase activity
EXW49_07495	COG1333	cytochrome c biogenesis protein
EXW49_07500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW49_07505	COG0745	RESPONSE REGULATOR receiver
EXW49_07510	COG5002	protein histidine kinase activity
EXW49_07515	COG2096	Adenosyltransferase
EXW49_07520	COG4942	peptidase
EXW49_07530	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW49_07535	COG1141	Ferredoxin
EXW49_07545	COG4955	Helix-turn-helix domain
EXW49_07550	COG0514	ATP-dependent DNA helicase (RecQ)
EXW49_07555	COG1266	CAAX protease self-immunity
EXW49_07565	COG1408	metallophosphoesterase
EXW49_07580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW49_07600	COG0492	ferredoxin-NADP+ reductase activity
EXW49_07605	COG0252	asparaginase activity
EXW49_07610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW49_07620	COG1304	FMN binding
EXW49_07655	COG1160	GTP binding
EXW49_07660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW49_07680	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW49_07690	COG0302	gtp cyclohydrolase
EXW49_07695	COG0142	geranyltranstransferase activity
EXW49_07700	COG2226	methyltransferase
EXW49_07705	COG0142	geranyltranstransferase activity
EXW49_07720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW49_07730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW49_07735	COG0457	Tetratricopeptide repeat
EXW49_07740	COG5582	Belongs to the UPF0302 family
EXW49_07755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW49_07770	COG4347	Protein of unknown function (DUF1405)
EXW49_07785	COG2738	Putative neutral zinc metallopeptidase
EXW49_07795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_07800	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW49_07805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW49_07810	COG1803	Methylglyoxal synthase
EXW49_07815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW49_07820	COG0438	transferase activity, transferring glycosyl groups
EXW49_07825	COG0617	tRNA 3'-terminal CCA addition
EXW49_07835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW49_07840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW49_07850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW49_07850	COG1199	ATP-dependent helicase activity
EXW49_07870	COG3935	DnaD domain protein
EXW49_07875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW49_07885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW49_07885	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW49_07890	COG3331	DNA recombination
EXW49_07925	COG4474	Belongs to the UPF0398 family
EXW49_07930	COG3599	regulation of cell shape
EXW49_07940	COG0116	Belongs to the methyltransferase superfamily
EXW49_07950	COG1199	ATP-dependent helicase activity
EXW49_07955	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW49_07965	COG0024	Methionine aminopeptidase
EXW49_07975	COG2233	PERMEase
EXW49_07980	COG2311	Membrane
EXW49_07985	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW49_07995	COG0456	acetyltransferase
EXW49_08005	COG2897	thiosulfate sulfurtransferase activity
EXW49_08045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW49_08070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW49_08085	COG1215	transferase activity, transferring glycosyl groups
EXW49_08090	COG0438	transferase activity, transferring glycosyl groups
EXW49_08105	COG0454	-acetyltransferase
EXW49_08125	COG0328	RNA-DNA hybrid ribonuclease activity
EXW49_08160	COG3403	YqcI/YcgG family
EXW49_08165	COG1280	lysine exporter protein (LysE YggA)
EXW49_08180	COG3162	membrane
EXW49_08185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW49_08190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW49_08200	COG0475	glutathione-regulated potassium exporter activity
EXW49_08205	COG4978	Transcriptional regulator
EXW49_08205	COG0789	Transcriptional regulator
EXW49_08215	COG2323	membrane
EXW49_08220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW49_08260	COG2814	Major facilitator Superfamily
EXW49_08280	COG1923	regulation of RNA biosynthetic process
EXW49_08290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW49_08295	COG1360	Flagellar Motor Protein
EXW49_08300	COG2201	protein-glutamate methylesterase activity
EXW49_08305	COG2198	Histidine kinase
EXW49_08305	COG0643	Histidine kinase
EXW49_08310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW49_08310	COG1776	CheC inhibitor of MCP methylation
EXW49_08325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW49_08345	COG1256	bacterial-type flagellum assembly
EXW49_08350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW49_08370	COG1815	bacterial-type flagellum-dependent cell motility
EXW49_08375	COG1558	bacterial-type flagellum-dependent cell motility
EXW49_08385	COG1766	The M ring may be actively involved in energy transduction
EXW49_08390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW49_08400	COG1157	protein secretion by the type III secretion system
EXW49_08420	COG1749	Flagellar hook protein flgE
EXW49_08435	COG0784	Response regulator, receiver
EXW49_08435	COG0835	chemotaxis
EXW49_08460	COG0861	Integral membrane protein TerC family
EXW49_08470	COG3383	formate dehydrogenase (NAD+) activity
EXW49_08475	COG2427	Protein of unknown function (DUF1641)
EXW49_08480	COG5609	conserved protein (DUF2294)
EXW49_08485	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW49_08495	COG2116	formate transmembrane transporter activity
EXW49_08500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW49_08505	COG0303	'Molybdopterin
EXW49_08510	COG0314	molybdopterin synthase activity
EXW49_08515	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXW49_08525	COG0489	protein tyrosine kinase activity
EXW49_08530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW49_08535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW49_08540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW49_08545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW49_08550	COG0741	lytic transglycosylase activity
EXW49_08560	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW49_08565	COG1776	CheC inhibitor of MCP methylation
EXW49_08565	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW49_08575	COG1338	Plays a role in the flagellum-specific transport system
EXW49_08580	COG1987	bacterial-type flagellum assembly
EXW49_08590	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW49_08595	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW49_08600	COG1419	protein localization to endoplasmic reticulum
EXW49_08605	COG4786	Flagellar basal body rod
EXW49_08610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW49_08645	COG2329	Antibiotic biosynthesis monooxygenase
EXW49_08660	COG2814	Major facilitator Superfamily
EXW49_08670	COG0583	DNA-binding transcription factor activity
EXW49_08675	COG3842	ATPase activity
EXW49_08725	COG0406	alpha-ribazole phosphatase activity
EXW49_08755	COG0367	asparagine synthase
EXW49_08785	COG1802	Transcriptional regulator
EXW49_08790	COG0697	spore germination
EXW49_08795	COG0438	transferase activity, transferring glycosyl groups
EXW49_08795	COG1216	Glycosyl transferase, family 2
EXW49_08800	COG1757	Na H antiporter
EXW49_08805	COG0789	Transcriptional regulator
EXW49_08810	COG4221	oxidoreductase activity
EXW49_08840	COG0534	Mate efflux family protein
EXW49_08845	COG3340	Belongs to the peptidase S51 family
EXW49_08865	COG0785	Cytochrome C biogenesis protein
EXW49_08870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_08885	COG3048	D-serine ammonia-lyase activity
EXW49_08890	COG2733	membrane
EXW49_08930	COG1131	(ABC) transporter
EXW49_08950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW49_08955	COG0528	UMP kinase activity
EXW49_08965	COG1027	Aspartate ammonia-lyase
EXW49_08970	COG0281	malic enzyme
EXW49_08975	COG4191	Histidine kinase
EXW49_08980	COG0784	Response regulator, receiver
EXW49_08985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW49_09000	COG2502	aspartate--ammonia ligase
EXW49_09050	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_09060	COG2814	Major facilitator Superfamily
EXW49_09090	COG0477	Major facilitator Superfamily
EXW49_09095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW49_09105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW49_09110	COG2223	nitrite transmembrane transporter activity
EXW49_09115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW49_09130	COG2244	polysaccharide biosynthetic process
EXW49_09135	COG0733	neurotransmitter:sodium symporter activity
EXW49_09145	COG5566	PFAM Mor transcription activator
EXW49_09150	COG2323	membrane
EXW49_09170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW49_09175	COG2132	Multicopper oxidase
EXW49_09185	COG5002	protein histidine kinase activity
EXW49_09190	COG0745	RESPONSE REGULATOR receiver
EXW49_09200	COG0129	dihydroxy-acid dehydratase activity
EXW49_09205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW49_09230	COG2814	Major facilitator Superfamily
EXW49_09235	COG3384	dioxygenase
EXW49_09260	COG4166	transmembrane transport
EXW49_09265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_09275	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW49_09280	COG1054	Belongs to the UPF0176 family
EXW49_09290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW49_09295	COG0531	amino acid
EXW49_09330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW49_09345	COG4257	antibiotic catabolic process
EXW49_09350	COG2390	Transcriptional regulator
EXW49_09360	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW49_09365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_09370	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW49_09385	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW49_09405	COG0583	DNA-binding transcription factor activity
EXW49_09420	COG0006	proline dipeptidase activity
EXW49_09425	COG2132	Multicopper oxidase
EXW49_09440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW49_09450	COG0583	DNA-binding transcription factor activity
EXW49_09470	COG1114	Component of the transport system for branched-chain amino acids
EXW49_09480	COG1834	amidinotransferase
EXW49_09490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_09535	COG2372	response to copper ion
EXW49_09535	COG1276	copper resistance
EXW49_09540	COG4549	nuclear export factor GLE1
EXW49_09550	COG0697	spore germination
EXW49_09555	COG0583	DNA-binding transcription factor activity
EXW49_09560	COG1959	2 iron, 2 sulfur cluster binding
EXW49_09565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW49_09570	COG0778	Nitroreductase
EXW49_09590	COG0628	permease
EXW49_09610	COG0523	cobalamin synthesis protein
EXW49_09620	COG0411	ABC transporter
EXW49_09640	COG0583	DNA-binding transcription factor activity
EXW49_09650	COG1942	4-Oxalocrotonate Tautomerase
EXW49_09665	COG0346	lactoylglutathione lyase activity
EXW49_09675	COG1271	oxidase subunit
EXW49_09680	COG1294	oxidase, subunit
EXW49_09685	COG4988	ABC transporter
EXW49_09690	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW49_09720	COG1686	Belongs to the peptidase S11 family
EXW49_09735	COG0791	NLP P60 protein
EXW49_09735	COG1388	LysM domain
EXW49_09745	COG1132	(ABC) transporter
EXW49_09750	COG0745	RESPONSE REGULATOR receiver
EXW49_09755	COG5002	protein histidine kinase activity
EXW49_09760	COG0300	oxidoreductase activity
EXW49_09765	COG4122	O-methyltransferase activity
EXW49_09780	COG5658	integral membrane protein
EXW49_09795	COG0460	homoserine dehydrogenase
EXW49_09805	COG0083	homoserine kinase activity
EXW49_09820	COG1316	TRANSCRIPTIONal
EXW49_09835	COG1285	pathogenesis
EXW49_09840	COG1247	-acetyltransferase
EXW49_09860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW49_09870	COG1082	Xylose isomerase domain protein TIM barrel
EXW49_09880	COG2814	Major facilitator Superfamily
EXW49_09885	COG1279	arginine transmembrane transporter activity
EXW49_09890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_09900	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW49_09930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW49_09935	COG0577	efflux transmembrane transporter activity
EXW49_09940	COG2002	toxin-antitoxin pair type II binding
EXW49_09945	COG1404	Belongs to the peptidase S8 family
EXW49_09950	COG0640	Transcriptional regulator
EXW49_09955	COG0667	Aldo Keto reductase
EXW49_10000	COG3949	Membrane
EXW49_10005	COG0783	Belongs to the Dps family
EXW49_10020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW49_10030	COG1231	oxidoreductase activity
EXW49_10035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_10040	COG4989	oxidoreductase activity
EXW49_10045	COG0523	cobalamin synthesis protein
EXW49_10050	COG0456	acetyltransferase
EXW49_10055	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW49_10070	COG1902	pentaerythritol trinitrate reductase activity
EXW49_10075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW49_10085	COG4166	transmembrane transport
EXW49_10090	COG0346	lactoylglutathione lyase activity
EXW49_10100	COG0406	alpha-ribazole phosphatase activity
EXW49_10110	COG5337	Spore coat protein CotH
EXW49_10115	COG1051	belongs to the nudix hydrolase family
EXW49_10120	COG0586	Pfam SNARE associated Golgi protein
EXW49_10125	COG2244	polysaccharide biosynthetic process
EXW49_10135	COG0701	Predicted permease
EXW49_10140	COG3689	TIGRFAM TIGR03943 family protein
EXW49_10145	COG1607	acyl-coa hydrolase
EXW49_10155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW49_10175	COG0702	epimerase
EXW49_10180	COG2839	Protein conserved in bacteria
EXW49_10185	COG1253	flavin adenine dinucleotide binding
EXW49_10210	COG1114	Component of the transport system for branched-chain amino acids
EXW49_10215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW49_10235	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_10250	COG1876	peptidase activity
EXW49_10255	COG0494	nUDIX hydrolase
EXW49_10260	COG0154	amidase activity
EXW49_10265	COG2211	Major facilitator Superfamily
EXW49_10280	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_10290	COG0561	phosphatase activity
EXW49_10295	COG1846	Transcriptional regulator
EXW49_10300	COG2814	Major facilitator Superfamily
EXW49_10310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW49_10315	COG4106	trans-aconitate 2-methyltransferase activity
EXW49_10330	COG1819	glycosyl
EXW49_10335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_10340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_10365	COG0456	acetyltransferase
EXW49_10400	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW49_10445	COG3874	Sporulation protein YtfJ
EXW49_10470	COG2226	methyltransferase
EXW49_10500	COG0604	alcohol dehydrogenase
EXW49_10505	COG1595	DNA-templated transcription, initiation
EXW49_10530	COG0426	domain, Protein
EXW49_10530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW49_10540	COG0386	Belongs to the glutathione peroxidase family
EXW49_10545	COG1305	Transglutaminase-like
EXW49_10550	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW49_10555	COG0714	Associated with various cellular activities
EXW49_10560	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW49_10565	COG1140	nitrate reductase beta subunit
EXW49_10570	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW49_10575	COG2181	nitrate reductase activity
EXW49_10580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW49_10585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW49_10590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW49_10595	COG0303	'Molybdopterin
EXW49_10600	COG0314	molybdopterin synthase activity
EXW49_10610	COG2223	nitrite transmembrane transporter activity
EXW49_10630	COG1648	precorrin-2 dehydrogenase activity
EXW49_10640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW49_10640	COG1587	Uroporphyrinogen-III synthase
EXW49_10645	COG2146	nitrite reductase [NAD(P)H] activity
EXW49_10650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW49_10655	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW49_10685	COG2359	stage V sporulation protein S
EXW49_10725	COG1418	mRNA catabolic process
EXW49_10730	COG0488	(ABC) transporter
EXW49_10760	COG1413	lyase activity
EXW49_10775	COG2521	methyltransferase
EXW49_10775	COG2136	Putative SAM-dependent methyltransferase
EXW49_10780	COG0018	arginyl-trna synthetase
EXW49_10795	COG2226	methyltransferase
EXW49_10830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW49_10840	COG0017	Asparaginyl-tRNA synthetase
EXW49_10845	COG0733	neurotransmitter:sodium symporter activity
EXW49_10875	COG2610	gluconate transmembrane transporter activity
EXW49_10885	COG1794	racemase activity, acting on amino acids and derivatives
EXW49_10895	COG0456	acetyltransferase
EXW49_10900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW49_10905	COG1131	(ABC) transporter
EXW49_10910	COG4473	ABC transporter
EXW49_10920	COG0546	phosphoglycolate phosphatase activity
EXW49_10980	COG0768	penicillin binding
EXW49_10995	COG1272	protein, Hemolysin III
EXW49_11005	COG0805	protein transport
EXW49_11015	COG1307	EDD domain protein, DegV family
EXW49_11020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW49_11025	COG1999	signal sequence binding
EXW49_11030	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW49_11035	COG0367	asparagine synthase
EXW49_11050	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW49_11055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_11060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW49_11080	COG1335	isochorismatase
EXW49_11090	COG0668	transmembrane transport
EXW49_11095	COG4585	Histidine kinase
EXW49_11095	COG2203	Gaf domain
EXW49_11100	COG2197	response regulator
EXW49_11105	COG1737	Transcriptional regulator
EXW49_11110	COG1064	alcohol dehydrogenase
EXW49_11130	COG1070	Carbohydrate kinase
EXW49_11140	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW49_11160	COG0517	IMP dehydrogenase activity
EXW49_11160	COG1125	glycine betaine transport
EXW49_11165	COG1174	glycine betaine transport
EXW49_11215	COG1253	flavin adenine dinucleotide binding
EXW49_11220	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_11225	COG5506	Protein of unknown function (DUF1694)
EXW49_11240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW49_11245	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW49_11250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW49_11255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW49_11260	COG0456	acetyltransferase
EXW49_11265	COG3829	transcription factor binding
EXW49_11270	COG1509	lysine 2,3-aminomutase activity
EXW49_11280	COG4479	Belongs to the UPF0346 family
EXW49_11305	COG4991	sh3 domain protein
EXW49_11305	COG3064	Membrane
EXW49_11305	COG0515	serine threonine protein kinase
EXW49_11315	COG0671	phosphoesterase, PA-phosphatase related
EXW49_11320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW49_11325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_11380	COG2801	Transposase and inactivated derivatives
EXW49_11410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW49_11455	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW49_11455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW49_11465	COG2814	Major facilitator Superfamily
EXW49_11475	COG0372	Belongs to the citrate synthase family
EXW49_11480	COG2079	MmgE PrpD family protein
EXW49_11485	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW49_11490	COG1960	acyl-CoA dehydrogenase activity
EXW49_11495	COG2084	Dehydrogenase
EXW49_11500	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_11505	COG1280	lysine exporter protein (LysE YggA)
EXW49_11510	COG1024	Enoyl-CoA hydratase
EXW49_11525	COG0420	3'-5' exonuclease activity
EXW49_11545	COG2223	nitrite transmembrane transporter activity
EXW49_11550	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_11555	COG1169	isochorismate synthase
EXW49_11560	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW49_11565	COG1535	isochorismatase
EXW49_11565	COG3433	isochorismatase activity
EXW49_11570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW49_11575	COG3251	PFAM MbtH domain protein
EXW49_11580	COG2814	Major facilitator Superfamily
EXW49_11595	COG0776	regulation of translation
EXW49_11605	COG2318	DinB family
EXW49_11610	COG1115	amino acid carrier protein
EXW49_11625	COG2329	Antibiotic biosynthesis monooxygenase
EXW49_11640	COG1187	pseudouridine synthase activity
EXW49_11645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW49_11650	COG3655	Transcriptional regulator
EXW49_11660	COG1136	(ABC) transporter
EXW49_11685	COG0028	Belongs to the TPP enzyme family
EXW49_11705	COG1253	flavin adenine dinucleotide binding
EXW49_11740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW49_11760	COG1846	Transcriptional regulator
EXW49_11775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_11780	COG1309	transcriptional regulator
EXW49_11810	COG1247	-acetyltransferase
EXW49_11820	COG0583	DNA-binding transcription factor activity
EXW49_11825	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW49_11870	COG0596	Alpha beta hydrolase
EXW49_11875	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW49_11885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_11915	COG0583	DNA-binding transcription factor activity
EXW49_11920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW49_11935	COG0583	DNA-binding transcription factor activity
EXW49_11940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW49_11945	COG2258	MOSC domain
EXW49_11960	COG1132	(ABC) transporter
EXW49_11965	COG1132	(ABC) transporter
EXW49_11985	COG1396	sequence-specific DNA binding
EXW49_12015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW49_12025	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW49_12030	COG1595	DNA-templated transcription, initiation
EXW49_12050	COG1649	PFAM Uncharacterised BCR, COG1649
EXW49_12070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW49_12075	COG2971	BadF BadG BcrA BcrD
EXW49_12145	COG1309	transcriptional regulator
EXW49_12160	COG1136	(ABC) transporter
EXW49_12160	COG0577	efflux transmembrane transporter activity
EXW49_12165	COG0500	methyltransferase
EXW49_12165	COG3615	Tellurite resistance protein tehB
EXW49_12175	COG0693	protein deglycase activity
EXW49_12185	COG0588	phosphoglycerate mutase activity
EXW49_12205	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW49_12210	COG0110	maltose O-acetyltransferase activity
EXW49_12225	COG1136	(ABC) transporter
EXW49_12250	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_12260	COG1686	Belongs to the peptidase S11 family
EXW49_12285	COG0768	penicillin binding
EXW49_12290	COG0745	RESPONSE REGULATOR receiver
EXW49_12295	COG2205	protein histidine kinase activity
EXW49_12300	COG1136	(ABC) transporter
EXW49_12305	COG0577	efflux transmembrane transporter activity
EXW49_12315	COG1595	DNA-templated transcription, initiation
EXW49_12325	COG0768	penicillin binding
EXW49_12330	COG0768	penicillin binding
EXW49_12365	COG1252	NADH dehydrogenase
EXW49_12370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_12370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_12385	COG0697	spore germination
EXW49_12415	COG3397	chitin binding
EXW49_12420	COG0823	Involved in the tonB-independent uptake of proteins
EXW49_12430	COG1408	metallophosphoesterase
EXW49_12440	COG1131	(ABC) transporter
EXW49_12450	COG1309	transcriptional regulator
EXW49_12460	COG1960	acyl-CoA dehydrogenase activity
EXW49_12465	COG0439	Biotin carboxylase
EXW49_12470	COG0511	ligase activity, forming carbon-carbon bonds
EXW49_12475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW49_12480	COG1024	Enoyl-CoA hydratase
EXW49_12485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW49_12490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW49_12530	COG0572	uridine kinase
EXW49_12535	COG2318	DinB family
EXW49_12565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW49_12620	COG1733	regulation of RNA biosynthetic process
EXW49_12645	COG1309	transcriptional regulator
EXW49_12660	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW49_12675	COG0697	spore germination
EXW49_12680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_12710	COG2323	membrane
EXW49_12715	COG2132	Multicopper oxidase
EXW49_12730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_12735	COG0697	spore germination
EXW49_12740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW49_12745	COG0201	protein transport
EXW49_12755	COG0737	Belongs to the 5'-nucleotidase family
EXW49_12760	COG3227	Zinc metalloprotease (Elastase)
EXW49_12765	COG1523	belongs to the glycosyl hydrolase 13 family
EXW49_12785	COG1073	alpha beta
EXW49_12795	COG0577	efflux transmembrane transporter activity
EXW49_12800	COG1136	(ABC) transporter
EXW49_12830	COG5002	protein histidine kinase activity
EXW49_12835	COG0745	RESPONSE REGULATOR receiver
EXW49_12840	COG1011	Hydrolase
EXW49_12865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW49_12870	COG1183	phosphatidylcholine synthase activity
EXW49_12880	COG1132	(ABC) transporter
EXW49_12890	COG3961	Belongs to the TPP enzyme family
EXW49_12910	COG0322	excinuclease ABC activity
EXW49_12935	COG2318	DinB family
EXW49_12950	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW49_12975	COG3878	Protein conserved in bacteria
EXW49_13000	COG1051	belongs to the nudix hydrolase family
EXW49_13005	COG0592	DNA-directed DNA polymerase activity
EXW49_13010	COG2816	NAD+ diphosphatase activity
EXW49_13020	COG2223	nitrite transmembrane transporter activity
EXW49_13025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_13035	COG0494	nUDIX hydrolase
EXW49_13055	COG0697	spore germination
EXW49_13060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_13075	COG0584	glycerophosphoryl diester phosphodiesterase
EXW49_13090	COG1733	regulation of RNA biosynthetic process
EXW49_13100	COG2814	Major facilitator Superfamily
EXW49_13115	COG2375	cellular response to nickel ion
EXW49_13115	COG1132	(ABC) transporter
EXW49_13120	COG1132	(ABC) transporter
EXW49_13155	COG0768	penicillin binding
EXW49_13160	COG0671	phosphoesterase, PA-phosphatase related
EXW49_13165	COG0604	alcohol dehydrogenase
EXW49_13170	COG5002	protein histidine kinase activity
EXW49_13175	COG0745	RESPONSE REGULATOR receiver
EXW49_13185	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW49_13195	COG2205	protein histidine kinase activity
EXW49_13210	COG1122	ATPase activity
EXW49_13215	COG4720	Psort location CytoplasmicMembrane, score
EXW49_13220	COG1794	racemase activity, acting on amino acids and derivatives
EXW49_13225	COG1819	glycosyl
EXW49_13235	COG0768	penicillin binding
EXW49_13240	COG5002	protein histidine kinase activity
EXW49_13245	COG0561	phosphatase activity
EXW49_13295	COG2124	cytochrome p450
EXW49_13345	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW49_13355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_13360	COG0460	homoserine dehydrogenase
EXW49_13380	COG0577	efflux transmembrane transporter activity
EXW49_13385	COG1136	(ABC) transporter
EXW49_13400	COG0488	(ABC) transporter
EXW49_13405	COG0667	Aldo Keto reductase
EXW49_13410	COG0583	DNA-binding transcription factor activity
EXW49_13420	COG2205	protein histidine kinase activity
EXW49_13425	COG0745	RESPONSE REGULATOR receiver
EXW49_13440	COG3773	Cell wall hydrolase
EXW49_13445	COG0604	alcohol dehydrogenase
EXW49_13490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_13505	COG2959	enzyme of heme biosynthesis
EXW49_13535	COG3483	tryptophan 2,3-dioxygenase activity
EXW49_13540	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW49_13545	COG3844	kynureninase activity
EXW49_13550	COG1309	transcriptional regulator
EXW49_13565	COG3284	Transcriptional regulator
EXW49_13580	COG1349	DNA-binding transcription factor activity
EXW49_13600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW49_13605	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW49_13610	COG0022	dehydrogenase e1 component
EXW49_13615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW49_13625	COG2223	nitrite transmembrane transporter activity
EXW49_13635	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_13640	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW49_13640	COG0456	acetyltransferase
EXW49_13675	COG4176	ABC-type proline glycine betaine transport system permease component
EXW49_13680	COG4175	Glycine betaine
EXW49_13680	COG0517	IMP dehydrogenase activity
EXW49_13705	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW49_13710	COG2153	protein acetylation
EXW49_13715	COG3397	chitin binding
EXW49_13725	COG1819	glycosyl
EXW49_13740	COG2205	protein histidine kinase activity
EXW49_13745	COG2315	Protein conserved in bacteria
EXW49_13795	COG3973	AAA domain
EXW49_13810	COG2105	PFAM AIG2 family protein
EXW49_13815	COG0514	ATP-dependent DNA helicase (RecQ)
EXW49_13835	COG4637	Psort location Cytoplasmic, score
EXW49_13855	COG1227	inorganic diphosphatase activity
EXW49_13860	COG3397	chitin binding
EXW49_13865	COG2318	DinB family
EXW49_13880	COG1162	GTPase activity
EXW49_13885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW49_13890	COG1115	amino acid carrier protein
EXW49_13895	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_13900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW49_13910	COG3938	Belongs to the proline racemase family
EXW49_13915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW49_13960	COG0586	Pfam SNARE associated Golgi protein
EXW49_13975	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW49_13980	COG4166	transmembrane transport
EXW49_13990	COG4948	Mandelate Racemase Muconate Lactonizing
EXW49_14010	COG0667	Aldo Keto reductase
EXW49_14055	COG2936	dipeptidyl-peptidase activity
EXW49_14065	COG0745	RESPONSE REGULATOR receiver
EXW49_14085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW49_14090	COG1164	Oligoendopeptidase f
EXW49_14110	COG1307	EDD domain protein, DegV family
EXW49_14140	COG1335	isochorismatase
EXW49_14155	COG2814	Major facilitator Superfamily
EXW49_14165	COG1664	Polymer-forming cytoskeletal
EXW49_14170	COG0789	Transcriptional regulator
EXW49_14175	COG4533	DNA binding
EXW49_14180	COG2814	Major facilitator Superfamily
EXW49_14180	COG0477	Major facilitator Superfamily
EXW49_14195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW49_14200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW49_14205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW49_14210	COG0438	transferase activity, transferring glycosyl groups
EXW49_14215	COG3328	transposase activity
EXW49_14235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW49_14240	COG0438	transferase activity, transferring glycosyl groups
EXW49_14245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW49_14260	COG2261	transglycosylase associated protein
EXW49_14275	COG2226	methyltransferase
EXW49_14310	COG0436	Aminotransferase
EXW49_14315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW49_14365	COG0628	permease
EXW49_14395	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW49_14405	COG0697	spore germination
EXW49_14430	COG4912	Dna alkylation repair
EXW49_14455	COG2814	Major facilitator Superfamily
EXW49_14460	COG1368	sulfuric ester hydrolase activity
EXW49_14470	COG0488	(ABC) transporter
EXW49_14475	COG2409	Drug exporters of the RND superfamily
EXW49_14475	COG1033	growth of symbiont in host cell
EXW49_14485	COG1309	transcriptional regulator
EXW49_14510	COG0287	Prephenate dehydrogenase
EXW49_14525	COG1605	Chorismate mutase
EXW49_14525	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW49_14555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EXW49_14575	COG1388	LysM domain
EXW49_14575	COG3584	3D domain protein
EXW49_14585	COG0346	lactoylglutathione lyase activity
EXW49_14595	COG0431	NADPH-dependent FMN reductase
EXW49_14625	COG0579	oxidoreductase
EXW49_14635	COG2390	Transcriptional regulator
EXW49_14655	COG2226	methyltransferase
EXW49_14670	COG0346	lactoylglutathione lyase activity
EXW49_14675	COG2329	Antibiotic biosynthesis monooxygenase
EXW49_14695	COG1472	Belongs to the glycosyl hydrolase 3 family
EXW49_14700	COG2207	Transcriptional regulator
EXW49_14705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_14715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW49_14720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW49_14725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW49_14730	COG3239	Fatty acid desaturase
EXW49_14750	COG3655	Transcriptional regulator
EXW49_14795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_14800	COG0346	lactoylglutathione lyase activity
EXW49_14820	COG0714	Associated with various cellular activities
EXW49_14840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW49_14845	COG0753	catalase activity
EXW49_14860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW49_14880	COG0778	Nitroreductase
EXW49_14885	COG1846	Transcriptional regulator
EXW49_14905	COG1051	belongs to the nudix hydrolase family
EXW49_14910	COG3831	ATPase activity
EXW49_14910	COG4884	unkown
EXW49_14930	COG2207	Transcriptional regulator
EXW49_14935	COG0456	acetyltransferase
EXW49_14950	COG0697	spore germination
EXW49_14955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_14960	COG1671	Belongs to the UPF0178 family
EXW49_14980	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW49_14980	COG0456	acetyltransferase
EXW49_15005	COG0730	response to heat
EXW49_15015	COG0833	amino acid
EXW49_15025	COG4335	DNA alkylation repair
EXW49_15055	COG0681	Belongs to the peptidase S26 family
EXW49_15060	COG0768	penicillin binding
EXW49_15070	COG3104	oligopeptide transport
EXW49_15075	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW49_15090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW49_15095	COG1984	allophanate hydrolase subunit 2
EXW49_15100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW49_15105	COG1414	Transcriptional regulator
EXW49_15135	COG1960	acyl-CoA dehydrogenase activity
EXW49_15160	COG0640	Transcriptional regulator
EXW49_15205	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW49_15220	COG3848	Pyruvate phosphate dikinase
EXW49_15220	COG0574	Belongs to the PEP-utilizing enzyme family
EXW49_15245	COG1136	(ABC) transporter
EXW49_15280	COG1073	alpha beta
EXW49_15330	COG5002	protein histidine kinase activity
EXW49_15335	COG0745	RESPONSE REGULATOR receiver
EXW49_15345	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW49_15360	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW49_15365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW49_15370	COG1121	(ABC) transporter
EXW49_15390	COG0798	PFAM Bile acid sodium symporter
EXW49_15395	COG0346	lactoylglutathione lyase activity
EXW49_15400	COG0640	Transcriptional regulator
EXW49_15410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW49_15410	COG3320	Male sterility
EXW49_15415	COG1309	transcriptional regulator
EXW49_15420	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_15425	COG1522	sequence-specific DNA binding
EXW49_15440	COG0346	lactoylglutathione lyase activity
EXW49_15470	COG2226	methyltransferase
EXW49_15480	COG2814	Major facilitator Superfamily
EXW49_15515	COG0745	RESPONSE REGULATOR receiver
EXW49_15520	COG3850	Histidine kinase
EXW49_15520	COG5002	protein histidine kinase activity
EXW49_15550	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW49_15570	COG0673	inositol 2-dehydrogenase activity
EXW49_15575	COG0673	inositol 2-dehydrogenase activity
EXW49_15580	COG2169	Transcriptional regulator
EXW49_15600	COG0789	Transcriptional regulator
EXW49_15605	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW49_15620	COG1136	(ABC) transporter
EXW49_15625	COG0577	efflux transmembrane transporter activity
EXW49_15645	COG5002	protein histidine kinase activity
EXW49_15645	COG3850	Histidine kinase
EXW49_15655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_15670	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW49_15695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW49_15755	COG2814	Major facilitator Superfamily
EXW49_15880	COG2801	Transposase and inactivated derivatives
EXW49_15960	COG0477	Major facilitator Superfamily
EXW49_15975	COG1846	Transcriptional regulator
EXW49_15980	COG2814	Major facilitator Superfamily
EXW49_16030	COG1476	TRANSCRIPTIONal
EXW49_16045	COG1288	antiporter activity
EXW49_16050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW49_16105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_16155	COG4187	Peptidase family M20/M25/M40
EXW49_16175	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW49_16180	COG2031	fatty acid transporter
EXW49_16190	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW49_16240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW49_16245	COG1288	antiporter activity
EXW49_16250	COG2356	endonuclease I
EXW49_16255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW49_16275	COG2801	Transposase and inactivated derivatives
EXW49_16280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW49_16300	COG1785	Belongs to the alkaline phosphatase family
EXW49_16305	COG0778	Nitroreductase
EXW49_16310	COG1733	regulation of RNA biosynthetic process
EXW49_16330	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_16340	COG1131	(ABC) transporter
EXW49_16370	COG1595	DNA-templated transcription, initiation
EXW49_16385	COG1011	Hydrolase
EXW49_16390	COG2365	Tyrosine phosphatase family
EXW49_16415	COG0346	lactoylglutathione lyase activity
EXW49_16420	COG1940	carbohydrate kinase activity
EXW49_16425	COG0738	Major facilitator superfamily
EXW49_16430	COG0110	maltose O-acetyltransferase activity
EXW49_16445	COG0628	permease
EXW49_16450	COG2261	transglycosylase associated protein
EXW49_16465	COG0500	methyltransferase
EXW49_16475	COG0477	Major facilitator Superfamily
EXW49_16495	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW49_16505	COG1253	flavin adenine dinucleotide binding
EXW49_16510	COG0789	Transcriptional regulator
EXW49_16515	COG0697	spore germination
EXW49_16525	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW49_16530	COG3813	Protein conserved in bacteria
EXW49_16535	COG4702	Belongs to the UPF0303 family
EXW49_16545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_16565	COG0384	phenazine biosynthesis protein PhzF
EXW49_16585	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_16590	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW49_16595	COG1733	regulation of RNA biosynthetic process
EXW49_16610	COG1191	sigma factor activity
EXW49_16640	COG1876	peptidase activity
EXW49_16685	COG2197	response regulator
EXW49_16760	COG0657	acetylesterase activity
EXW49_16770	COG2814	Major facilitator Superfamily
EXW49_16775	COG1309	transcriptional regulator
EXW49_16790	COG2224	Isocitrate lyase
EXW49_16820	COG0814	amino acid
EXW49_16845	COG1151	hydroxylamine reductase activity
EXW49_16875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_16885	COG2072	flavoprotein involved in K transport
EXW49_16930	COG1695	Transcriptional regulator
EXW49_16935	COG0604	alcohol dehydrogenase
EXW49_16940	COG1113	amino acid transport
EXW49_16950	COG2814	Major facilitator Superfamily
EXW49_16965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW49_16970	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_16980	COG0534	Mate efflux family protein
EXW49_16985	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_16990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW49_17005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW49_17010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW49_17030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_17035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_17040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_17045	COG3739	integral membrane protein
EXW49_17070	COG0583	DNA-binding transcription factor activity
EXW49_17090	COG1193	negative regulation of DNA recombination
EXW49_17110	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW49_17115	COG1164	Oligoendopeptidase f
EXW49_17120	COG2957	Belongs to the agmatine deiminase family
EXW49_17140	COG3781	membrane
EXW49_17155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW49_17195	COG3973	AAA domain
EXW49_17205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW49_17210	COG0640	Transcriptional regulator
EXW49_17215	COG0604	alcohol dehydrogenase
EXW49_17220	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW49_17225	COG0457	Tetratricopeptide repeat
EXW49_17235	COG2808	Putative FMN-binding domain
EXW49_17240	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW49_17250	COG0277	FAD linked oxidase domain protein
EXW49_17270	COG1285	pathogenesis
EXW49_17280	COG2514	catechol 2,3-dioxygenase activity
EXW49_17285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_17290	COG1126	abc transporter atp-binding protein
EXW49_17295	COG0765	amino acid transport
EXW49_17300	COG2720	vancomycin resistance protein
EXW49_17325	COG1278	Cold shock
EXW49_17335	COG0716	FMN binding
EXW49_17345	COG0494	nUDIX hydrolase
EXW49_17365	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_17375	COG0165	Argininosuccinate lyase
EXW49_17390	COG4145	pantothenate transmembrane transporter activity
EXW49_17400	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_17405	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_17415	COG1657	PFAM Prenyltransferase squalene oxidase
EXW49_17420	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW49_17425	COG2962	Rard protein
EXW49_17430	COG3326	Membrane
EXW49_17460	COG2226	methyltransferase
EXW49_17465	COG4166	transmembrane transport
EXW49_17470	COG4166	transmembrane transport
EXW49_17475	COG4166	transmembrane transport
EXW49_17480	COG1316	TRANSCRIPTIONal
EXW49_17490	COG1595	DNA-templated transcription, initiation
EXW49_17500	COG1131	(ABC) transporter
EXW49_17520	COG0673	inositol 2-dehydrogenase activity
EXW49_17525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW49_17530	COG0187	DNA topoisomerase II activity
EXW49_17535	COG1832	CoA-binding protein
EXW49_17540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW49_17545	COG0745	RESPONSE REGULATOR receiver
EXW49_17555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW49_17555	COG1328	CTP reductase activity
EXW49_17565	COG4841	protein insertion into membrane
EXW49_17570	COG0824	Thioesterase
EXW49_17595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_17630	COG1132	(ABC) transporter
EXW49_17635	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW49_17665	COG2211	Major facilitator Superfamily
EXW49_17675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW49_17690	COG0183	Belongs to the thiolase family
EXW49_17695	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_17700	COG1268	BioY protein
EXW49_17705	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_17710	COG1396	sequence-specific DNA binding
EXW49_17755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_17770	COG5002	protein histidine kinase activity
EXW49_17775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW49_17790	COG4974	Belongs to the 'phage' integrase family
EXW49_17805	COG0400	carboxylic ester hydrolase activity
EXW49_17810	COG0346	lactoylglutathione lyase activity
EXW49_17815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW49_17820	COG0069	glutamate synthase activity
EXW49_17825	COG1902	pentaerythritol trinitrate reductase activity
EXW49_17835	COG1329	Transcriptional regulator
EXW49_17840	COG0010	Belongs to the arginase family
EXW49_17850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW49_17855	COG2986	histidine ammonia-lyase
EXW49_17865	COG2226	methyltransferase
EXW49_17895	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW49_17900	COG0785	Cytochrome C biogenesis protein
EXW49_17915	COG1473	amidohydrolase
EXW49_17920	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW49_17925	COG1131	(ABC) transporter
EXW49_17935	COG0583	DNA-binding transcription factor activity
EXW49_17945	COG1346	cytolysis
EXW49_17960	COG0730	response to heat
EXW49_17970	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW49_17970	COG3409	Peptidoglycan-binding domain 1 protein
EXW49_17990	COG1132	(ABC) transporter
EXW49_17995	COG1132	(ABC) transporter
EXW49_18000	COG3763	UPF0154 protein
EXW49_18020	COG3639	organic phosphonate transmembrane transporter activity
EXW49_18030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_18035	COG0737	Belongs to the 5'-nucleotidase family
EXW49_18045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW49_18050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW49_18065	COG1695	Transcriptional regulator
EXW49_18070	COG0174	glutamine synthetase
EXW49_18075	COG0789	Transcriptional regulator
EXW49_18080	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW49_18085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW49_18090	COG2860	membrane
EXW49_18095	COG0464	growth
EXW49_18115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW49_18125	COG1388	LysM domain
EXW49_18125	COG3584	3D domain protein
EXW49_18130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW49_18130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW49_18130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW49_18135	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW49_18140	COG1349	DNA-binding transcription factor activity
EXW49_18145	COG1979	alcohol dehydrogenase
EXW49_18150	COG2322	membrane
EXW49_18160	COG1113	amino acid transport
EXW49_18180	COG1408	metallophosphoesterase
EXW49_18200	COG2217	Heavy metal translocating P-type atpase
EXW49_18205	COG2608	mercury ion transmembrane transporter activity
EXW49_18210	COG1937	Protein conserved in bacteria
EXW49_18230	COG2819	hydrolase of the alpha beta superfamily
EXW49_18235	COG1120	ATPase activity
EXW49_18240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_18245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_18250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_18255	COG0708	Exodeoxyribonuclease III
EXW49_18260	COG2169	Transcriptional regulator
EXW49_18265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW49_18270	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW49_18275	COG2706	6-phosphogluconolactonase activity
EXW49_18280	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW49_18285	COG2364	Membrane
EXW49_18295	COG0346	lactoylglutathione lyase activity
EXW49_18300	COG3300	MHYT domain
EXW49_18300	COG5001	Diguanylate cyclase
EXW49_18340	COG1346	cytolysis
EXW49_18350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW49_18355	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW49_18355	COG0596	Alpha beta hydrolase
EXW49_18360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW49_18370	COG2188	Transcriptional regulator
EXW49_18375	COG2723	6-phospho-beta-galactosidase activity
EXW49_18385	COG3773	Cell wall hydrolase
EXW49_18395	COG1368	sulfuric ester hydrolase activity
EXW49_18400	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW49_18410	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW49_18420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW49_18425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW49_18435	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW49_18440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW49_18445	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW49_18450	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW49_18450	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW49_18460	COG2359	stage V sporulation protein S
EXW49_18465	COG1692	metallophosphoesterase
EXW49_18470	COG1418	mRNA catabolic process
EXW49_18475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW49_18480	COG1058	Belongs to the CinA family
EXW49_18480	COG1546	Belongs to the CinA family
EXW49_18485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW49_18490	COG1426	Protein conserved in bacteria
EXW49_18505	COG0300	oxidoreductase activity
EXW49_18510	COG0612	Peptidase, M16
EXW49_18515	COG0612	Peptidase, M16
EXW49_18520	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW49_18525	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW49_18530	COG3845	ABC transporter
EXW49_18535	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW49_18540	COG2188	Transcriptional regulator
EXW49_18545	COG1674	ftsk spoiiie
EXW49_18555	COG0740	serine-type endopeptidase activity
EXW49_18560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW49_18570	COG0527	aspartate kinase activity
EXW49_18575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW49_18580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW49_18625	COG4824	toxin secretion phage lysis holin
EXW49_18735	COG1278	Cold shock
EXW49_18745	COG0582	viral genome integration into host DNA
EXW49_18795	COG0305	Participates in initiation and elongation during chromosome replication
EXW49_18830	COG1396	sequence-specific DNA binding
EXW49_18855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW49_18860	COG1873	PFAM PRC-barrel domain
EXW49_18865	COG0612	Peptidase, M16
EXW49_18870	COG0726	polysaccharide deacetylase
EXW49_18875	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW49_18885	COG0196	riboflavin kinase activity
EXW49_18895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW49_18900	COG1550	Protein conserved in bacteria
EXW49_18905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW49_18910	COG1358	cellular component organization or biogenesis
EXW49_18915	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW49_18920	COG0195	Participates in both transcription termination and antitermination
EXW49_18925	COG0779	Required for maturation of 30S ribosomal subunits
EXW49_18935	COG0442	prolyl-tRNA aminoacylation
EXW49_18940	COG0750	zinc metalloprotease
EXW49_18950	COG4589	Belongs to the CDS family
EXW49_18960	COG0233	cytoplasmic translational termination
EXW49_18965	COG0528	UMP kinase activity
EXW49_18970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW49_18975	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW49_18980	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW49_18985	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW49_18990	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW49_18995	COG4974	Belongs to the 'phage' integrase family
EXW49_19000	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW49_19005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW49_19010	COG0758	DNA mediated transformation
EXW49_19015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW49_19020	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW49_19025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW49_19040	COG0335	large ribosomal subunit rRNA binding
EXW49_19045	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW49_19050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW49_19055	COG1837	Belongs to the UPF0109 family
EXW49_19065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW49_19070	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EXW49_19075	COG0552	protein localization to endoplasmic reticulum
EXW49_19080	COG1196	nuclear chromosome segregation
EXW49_19085	COG0571	ribonuclease III activity
EXW49_19090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW49_19095	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_19100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW49_19105	COG0416	fatty acid biosynthetic process
EXW49_19110	COG1349	DNA-binding transcription factor activity
EXW49_19110	COG2050	protein possibly involved in aromatic compounds catabolism
EXW49_19115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW49_19120	COG1461	Dihydroxyacetone kinase
EXW49_19125	COG1302	Protein conserved in bacteria
EXW49_19140	COG1564	THIamine pyrophosphokinase
EXW49_19145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW49_19155	COG0515	serine threonine protein kinase
EXW49_19155	COG2815	serine threonine protein kinase
EXW49_19160	COG0631	protein serine/threonine phosphatase activity
EXW49_19165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW49_19170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW49_19170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW49_19175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW49_19180	COG0242	peptide deformylase activity
EXW49_19185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW49_19190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW49_19195	COG1758	RNA polymerase activity
EXW49_19210	COG1561	YicC-like family, N-terminal region
EXW49_19215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW49_19230	COG0006	proline dipeptidase activity
EXW49_19300	COG0167	dihydroorotate dehydrogenase activity
EXW49_19305	COG0543	2 iron, 2 sulfur cluster binding
EXW49_19310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW49_19320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW49_19325	COG0540	Belongs to the ATCase OTCase family
EXW49_19335	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW49_19340	COG0564	pseudouridine synthase activity
EXW49_19345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW49_19355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW49_19360	COG3599	regulation of cell shape
EXW49_19365	COG2302	S4 RNA-binding domain
EXW49_19370	COG0762	integral membrane protein
EXW49_19375	COG1799	cell septum assembly
EXW49_19380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW49_19390	COG1873	PFAM PRC-barrel domain
EXW49_19395	COG1191	sigma factor activity
EXW49_19400	COG1191	sigma factor activity
EXW49_19410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW49_19415	COG0849	cell division
EXW49_19420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW49_19435	COG0772	Belongs to the SEDS family
EXW49_19440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW49_19445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW49_19450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW49_19455	COG0768	penicillin binding
EXW49_19460	COG0768	penicillin binding
EXW49_19470	COG0275	rRNA processing
EXW49_19475	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW49_19480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW49_19485	COG0454	-acetyltransferase
EXW49_19495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW49_19500	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW49_19505	COG1323	Belongs to the UPF0348 family
EXW49_19510	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW49_19515	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW49_19520	COG3314	Sporulation integral membrane protein YlbJ
EXW49_19525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EXW49_19530	COG0742	ribosomal rna small subunit methyltransferase
EXW49_19540	COG4471	UPF0298 protein
EXW49_19545	COG3679	Belongs to the UPF0342 family
EXW49_19550	COG0406	alpha-ribazole phosphatase activity
EXW49_19565	COG2340	Cysteine-rich secretory protein family
EXW49_19575	COG3336	cytochrome c oxidase
EXW49_19600	COG0109	protoheme IX farnesyltransferase activity
EXW49_19605	COG1612	heme a metabolic process
EXW49_19610	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW49_19620	COG0772	Belongs to the SEDS family
EXW49_19625	COG4838	Belongs to the UPF0358 family
EXW49_19630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW49_19635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW49_19645	COG4896	Protein conserved in bacteria
EXW49_19660	COG1217	gtp-binding protein TYPA
EXW49_19670	COG0483	inositol monophosphate 1-phosphatase activity
EXW49_19680	COG4493	Belongs to the UPF0637 family
EXW49_19685	COG4476	Belongs to the UPF0223 family
EXW49_19695	COG1982	Orn Lys Arg decarboxylase major
EXW49_19740	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW49_19745	COG0022	dehydrogenase e1 component
EXW49_19750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW49_19765	COG0561	phosphatase activity
EXW49_19775	COG5503	Protein of unknown function (DUF1447)
EXW49_19780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW49_19785	COG0569	domain protein
EXW49_19795	COG1473	amidohydrolase
EXW49_19800	COG2171	N-acyltransferase activity
EXW49_19805	COG0583	DNA-binding transcription factor activity
EXW49_19810	COG0517	IMP dehydrogenase activity
EXW49_19820	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW49_19830	COG4703	Protein of unknown function (DUF1797)
EXW49_19845	COG2200	EAL domain
EXW49_19850	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_19855	COG1408	metallophosphoesterase
EXW49_19900	COG2814	Major facilitator Superfamily
EXW49_19910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW49_19920	COG3209	COG3209 Rhs family protein
EXW49_19930	COG2205	protein histidine kinase activity
EXW49_19940	COG0436	Aminotransferase
EXW49_19945	COG1609	Transcriptional regulator
EXW49_19950	COG3833	ABC-type maltose transport systems, permease component
EXW49_19955	COG1175	transmembrane transport
EXW49_19960	COG2182	Extracellular solute-binding protein
EXW49_19970	COG0366	Alpha amylase catalytic
EXW49_19975	COG3842	ATPase activity
EXW49_20020	COG0183	Belongs to the thiolase family
EXW49_20055	COG1695	Transcriptional regulator
EXW49_20060	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_20070	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW49_20075	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW49_20080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW49_20085	COG0436	Aminotransferase
EXW49_20090	COG1850	ribulose-bisphosphate carboxylase activity
EXW49_20095	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW49_20100	COG0235	Class ii aldolase
EXW49_20120	COG2084	Dehydrogenase
EXW49_20130	COG2199	diguanylate cyclase activity
EXW49_20135	COG0778	Nitroreductase
EXW49_20160	COG1263	PTS System
EXW49_20160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW49_20160	COG2190	(PTS) system
EXW49_20165	COG3711	transcriptional antiterminator
EXW49_20175	COG2188	Transcriptional regulator
EXW49_20180	COG0363	glucosamine-6-phosphate deaminase activity
EXW49_20185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW49_20195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW49_20205	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW49_20215	COG1547	Domain of unknown function (DUF309)
EXW49_20225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW49_20230	COG4086	secreted protein
EXW49_20235	COG0561	phosphatase activity
EXW49_20240	COG0697	spore germination
EXW49_20255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW49_20280	COG0733	neurotransmitter:sodium symporter activity
EXW49_20300	COG1686	Belongs to the peptidase S11 family
EXW49_20310	COG1725	Transcriptional regulator
EXW49_20315	COG1131	(ABC) transporter
EXW49_20335	COG1846	Transcriptional regulator
EXW49_20350	COG0598	Magnesium transport protein CorA
EXW49_20365	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW49_20375	COG4974	Belongs to the 'phage' integrase family
EXW49_20385	COG0735	belongs to the Fur family
EXW49_20390	COG1300	Membrane
EXW49_20410	COG0667	Aldo Keto reductase
EXW49_20415	COG0656	L-ascorbic acid biosynthetic process
EXW49_20420	COG0456	acetyltransferase
EXW49_20420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW49_20430	COG4085	toxin activity
EXW49_20430	COG0737	Belongs to the 5'-nucleotidase family
EXW49_20430	COG1525	nuclease
EXW49_20435	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW49_20445	COG0596	Alpha beta hydrolase
EXW49_20450	COG2056	Na+-H+ antiporter family
EXW49_20455	COG1609	Transcriptional regulator
EXW49_20460	COG0456	acetyltransferase
EXW49_20465	COG1073	alpha beta
EXW49_20490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW49_20490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW49_20495	COG0307	riboflavin synthase, alpha
EXW49_20500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW49_20500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW49_20515	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW49_20520	COG4106	trans-aconitate 2-methyltransferase activity
EXW49_20525	COG1073	alpha beta
EXW49_20525	COG2226	methyltransferase
EXW49_20530	COG0156	8-amino-7-oxononanoate synthase activity
EXW49_20540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW49_20550	COG1757	Na H antiporter
EXW49_20555	COG0737	Belongs to the 5'-nucleotidase family
EXW49_20565	COG1522	sequence-specific DNA binding
EXW49_20590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXW49_20600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW49_20610	COG0300	oxidoreductase activity
EXW49_20615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_20620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW49_20625	COG1760	l-serine dehydratase
EXW49_20630	COG1760	l-serine dehydratase
EXW49_20640	COG1234	tRNA 3'-trailer cleavage
EXW49_20665	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW49_20670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_20680	COG1376	ErfK ybiS ycfS ynhG family protein
EXW49_20685	COG4129	membrane
EXW49_20690	COG1126	abc transporter atp-binding protein
EXW49_20695	COG0765	amino acid transport
EXW49_20700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW49_20715	COG2816	NAD+ diphosphatase activity
EXW49_20720	COG2323	membrane
EXW49_20725	COG0772	Belongs to the SEDS family
EXW49_20735	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW49_20740	COG0022	dehydrogenase e1 component
EXW49_20745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW49_20750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW49_20755	COG3426	butyrate kinase activity
EXW49_20765	COG0280	phosphate acetyltransferase
EXW49_20775	COG3290	protein histidine kinase activity
EXW49_20775	COG3829	transcription factor binding
EXW49_20785	COG0584	glycerophosphoryl diester phosphodiesterase
EXW49_20790	COG3093	addiction module antidote protein HigA
EXW49_20800	COG0745	RESPONSE REGULATOR receiver
EXW49_20810	COG0750	zinc metalloprotease
EXW49_20815	COG0497	DNA recombination
EXW49_20820	COG1438	arginine binding
EXW49_20825	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW49_20830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW49_20835	COG0142	geranyltranstransferase activity
EXW49_20840	COG1722	exodeoxyribonuclease VII activity
EXW49_20845	COG1570	exodeoxyribonuclease VII activity
EXW49_20850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW49_20855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW49_20860	COG1302	Protein conserved in bacteria
EXW49_20865	COG0439	Biotin carboxylase
EXW49_20870	COG0511	ligase activity, forming carbon-carbon bonds
EXW49_20915	COG3854	ATPases associated with a variety of cellular activities
EXW49_20935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW49_20940	COG0006	proline dipeptidase activity
EXW49_20945	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW49_20955	COG3872	metal-dependent enzyme
EXW49_20965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW49_20970	COG1321	iron dependent repressor
EXW49_21005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_21015	COG1609	Transcriptional regulator
EXW49_21025	COG2076	Multidrug Resistance protein
EXW49_21030	COG2076	Multidrug Resistance protein
EXW49_21065	COG1725	Transcriptional regulator
EXW49_21080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW49_21085	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW49_21090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW49_21095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW49_21105	COG2801	Transposase and inactivated derivatives
EXW49_21135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW49_21160	COG4970	Tfp pilus assembly protein FimT
EXW49_21170	COG1459	type II secretion system
EXW49_21175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW49_21230	COG0646	methionine synthase
EXW49_21230	COG1410	methionine synthase
EXW49_21235	COG0646	methionine synthase
EXW49_21235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW49_21240	COG0626	cystathionine gamma-synthase activity
EXW49_21245	COG0626	cystathionine gamma-synthase activity
EXW49_21260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_21270	COG1940	carbohydrate kinase activity
EXW49_21275	COG4483	Protein conserved in bacteria
EXW49_21280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW49_21285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW49_21290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW49_21295	COG0704	Plays a role in the regulation of phosphate uptake
EXW49_21305	COG0581	inorganic phosphate transmembrane transporter activity
EXW49_21310	COG0573	inorganic phosphate transmembrane transporter activity
EXW49_21315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW49_21320	COG0768	penicillin binding
EXW49_21325	COG0477	Major facilitator Superfamily
EXW49_21330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW49_21350	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW49_21355	COG0735	belongs to the Fur family
EXW49_21360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW49_21365	COG1121	(ABC) transporter
EXW49_21370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_21380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW49_21395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW49_21400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW49_21405	COG2384	SAM-dependent methyltransferase
EXW49_21415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW49_21420	COG0358	DNA primase activity
EXW49_21430	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW49_21435	COG0517	IMP dehydrogenase activity
EXW49_21440	COG1381	Involved in DNA repair and RecF pathway recombination
EXW49_21450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW49_21455	COG0295	cytidine deaminase activity
EXW49_21460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW49_21465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW49_21470	COG1480	7TM receptor with intracellular HD hydrolase
EXW49_21475	COG1702	phosphate starvation-inducible protein PhoH
EXW49_21490	COG1610	YqeY-like protein
EXW49_21495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW49_21500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW49_21505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW49_21515	COG0484	heat shock protein binding
EXW49_21520	COG0443	Heat shock 70 kDa protein
EXW49_21530	COG1420	regulation of RNA biosynthetic process
EXW49_21535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW49_21540	COG1733	regulation of RNA biosynthetic process
EXW49_21545	COG0481	GTPase activity
EXW49_21555	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW49_21560	COG0268	Binds directly to 16S ribosomal RNA
EXW49_21565	COG1466	dna polymerase III delta subunit
EXW49_21575	COG2333	competence protein COMEC
EXW49_21575	COG0658	competence protein
EXW49_21580	COG2131	deaminase
EXW49_21585	COG1555	photosystem II stabilization
EXW49_21585	COG1596	polysaccharide export
EXW49_21590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW49_21595	COG2226	methyltransferase
EXW49_21600	COG0799	negative regulation of ribosome biogenesis
EXW49_21605	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW49_21610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW49_21615	COG1534	Rna-binding protein
EXW49_21620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW49_21625	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW49_21630	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW49_21640	COG0688	phosphatidylethanolamine metabolic process
EXW49_21650	COG1595	DNA-templated transcription, initiation
EXW49_21655	COG2357	RelA SpoT domain protein
EXW49_21665	COG1785	Belongs to the alkaline phosphatase family
EXW49_21675	COG2267	carboxylic ester hydrolase activity
EXW49_21710	COG1404	Belongs to the peptidase S8 family
EXW49_21715	COG3186	Phenylalanine-4-hydroxylase
EXW49_21720	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW49_21725	COG2514	catechol 2,3-dioxygenase activity
EXW49_21730	COG2259	Doxx family
EXW49_21770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_21780	COG1012	belongs to the aldehyde dehydrogenase family
EXW49_21780	COG1454	alcohol dehydrogenase
EXW49_21785	COG0626	cystathionine gamma-synthase activity
EXW49_21790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW49_21795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW49_21800	COG2226	methyltransferase
EXW49_21815	COG0768	penicillin binding
EXW49_21820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW49_21825	COG0572	uridine kinase
EXW49_21830	COG0826	peptidase U32
EXW49_21835	COG0826	peptidase U32
EXW49_21840	COG4122	O-methyltransferase activity
EXW49_21845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW49_21855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW49_21860	COG4472	Bacterial protein of unknown function (DUF965)
EXW49_21865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW49_21875	COG0628	permease
EXW49_21895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW49_21905	COG0482	sulfurtransferase activity
EXW49_21910	COG1104	cysteine desulfurase activity
EXW49_21915	COG1959	2 iron, 2 sulfur cluster binding
EXW49_21920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW49_21930	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW49_21935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW49_21950	COG1490	D-aminoacyl-tRNA deacylase activity
EXW49_21955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW49_21960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW49_21965	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW49_21965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW49_21970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW49_21975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW49_21975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW49_21985	COG2244	polysaccharide biosynthetic process
EXW49_21990	COG2323	membrane
EXW49_22000	COG1862	Preprotein translocase
EXW49_22005	COG0343	queuine tRNA-ribosyltransferase activity
EXW49_22020	COG2255	four-way junction helicase activity
EXW49_22025	COG0632	four-way junction helicase activity
EXW49_22030	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW49_22040	COG2801	Transposase and inactivated derivatives
EXW49_22065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW49_22070	COG0157	Belongs to the NadC ModD family
EXW49_22075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW49_22080	COG1104	cysteine desulfurase activity
EXW49_22085	COG1827	regulation of RNA biosynthetic process
EXW49_22090	COG2258	MOSC domain
EXW49_22095	COG0077	Prephenate dehydratase
EXW49_22100	COG0577	efflux transmembrane transporter activity
EXW49_22105	COG0577	efflux transmembrane transporter activity
EXW49_22110	COG1136	(ABC) transporter
EXW49_22115	COG5002	protein histidine kinase activity
EXW49_22120	COG0745	RESPONSE REGULATOR receiver
EXW49_22125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW49_22130	COG3290	protein histidine kinase activity
EXW49_22140	COG2868	ribosomal protein
EXW49_22150	COG1530	ribonuclease E activity
EXW49_22155	COG1994	Peptidase M50
EXW49_22160	COG0739	heme binding
EXW49_22165	COG2894	cell division
EXW49_22170	COG0850	regulation of cytokinetic process
EXW49_22185	COG1077	Cell shape determining protein MreB Mrl
EXW49_22190	COG2003	Belongs to the UPF0758 family
EXW49_22195	COG0424	maF-like protein
EXW49_22210	COG0285	dihydrofolate synthase activity
EXW49_22225	COG1388	LysM domain
EXW49_22230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW49_22235	COG0113	porphobilinogen synthase activity
EXW49_22240	COG1587	Uroporphyrinogen-III synthase
EXW49_22245	COG0181	hydroxymethylbilane synthase activity
EXW49_22250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW49_22255	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW49_22260	COG1846	Transcriptional regulator
EXW49_22265	COG1764	response to oxidative stress
EXW49_22270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW49_22280	COG0470	DNA polymerase III
EXW49_22280	COG1067	ATP-dependent peptidase activity
EXW49_22290	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW49_22320	COG0622	Phosphoesterase
EXW49_22330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW49_22335	COG5401	PFAM Sporulation and spore germination
EXW49_22345	COG2197	response regulator
EXW49_22350	COG2233	PERMEase
EXW49_22355	COG0402	S-adenosylhomocysteine deaminase activity
EXW49_22360	COG1983	PspC domain protein
EXW49_22365	COG1396	sequence-specific DNA binding
EXW49_22370	COG0697	spore germination
EXW49_22380	COG1959	2 iron, 2 sulfur cluster binding
EXW49_22385	COG1668	transmembrane transport
EXW49_22390	COG4152	abc transporter atp-binding protein
EXW49_22395	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW49_22400	COG1360	Flagellar Motor Protein
EXW49_22405	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW49_22415	COG1876	peptidase activity
EXW49_22420	COG0824	Thioesterase
EXW49_22425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW49_22430	COG1053	succinate dehydrogenase
EXW49_22435	COG2009	succinate dehydrogenase
EXW49_22440	COG1719	4-vinyl reductase, 4VR
EXW49_22445	COG0322	excinuclease ABC activity
EXW49_22450	COG3118	belongs to the thioredoxin family
EXW49_22455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW49_22460	COG2086	electron transfer activity
EXW49_22465	COG1024	Enoyl-CoA hydratase
EXW49_22470	COG1309	transcriptional regulator
EXW49_22475	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_22495	COG2318	DinB family
EXW49_22515	COG1131	(ABC) transporter
EXW49_22520	COG2205	protein histidine kinase activity
EXW49_22525	COG0745	RESPONSE REGULATOR receiver
EXW49_22530	COG4895	conserved protein (DUF2196)
EXW49_22535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW49_22545	COG2329	Antibiotic biosynthesis monooxygenase
EXW49_22550	COG4509	Sortase family
EXW49_22555	COG1120	ATPase activity
EXW49_22570	COG5386	Cell surface protein
EXW49_22580	COG5386	Cell surface protein
EXW49_22585	COG1114	Component of the transport system for branched-chain amino acids
EXW49_22595	COG1193	negative regulation of DNA recombination
EXW49_22600	COG1796	DNA polymerase
EXW49_22600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW49_22605	COG1286	toxin biosynthetic process
EXW49_22610	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW49_22615	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW49_22640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW49_22645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW49_22655	COG1418	mRNA catabolic process
EXW49_22685	COG2814	Major facilitator Superfamily
EXW49_22690	COG1566	PFAM secretion protein HlyD family protein
EXW49_22695	COG1309	transcriptional regulator
EXW49_22700	COG1363	Peptidase, m42
EXW49_22710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW49_22725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW49_22735	COG1484	DNA-dependent DNA replication
EXW49_22740	COG3611	Membrane attachment protein
EXW49_22745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW49_22750	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW49_22755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW49_22760	COG0237	dephospho-CoA kinase activity
EXW49_22765	COG1971	Probably functions as a manganese efflux pump
EXW49_22775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW49_22775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW49_22780	COG5002	protein histidine kinase activity
EXW49_22785	COG0745	RESPONSE REGULATOR receiver
EXW49_22800	COG0039	L-malate dehydrogenase activity
EXW49_22805	COG0538	isocitrate dehydrogenase activity
EXW49_22810	COG0372	Belongs to the citrate synthase family
EXW49_22830	COG0628	permease
EXW49_22835	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW49_22845	COG0205	6-phosphofructokinase activity
EXW49_22855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW49_22860	COG1725	Transcriptional regulator
EXW49_22865	COG0281	malic enzyme
EXW49_22870	COG0587	DNA-directed DNA polymerase activity
EXW49_22885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW49_22905	COG4109	DRTGG domain
EXW49_22910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW49_22915	COG0006	proline dipeptidase activity
EXW49_22950	COG0662	Cupin 2, conserved barrel domain protein
EXW49_22975	COG1028	Short-chain dehydrogenase reductase Sdr
EXW49_22980	COG0589	response to stress
EXW49_23010	COG0137	argininosuccinate synthase activity
EXW49_23025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_23045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW49_23050	COG0827	DNA restriction-modification system
EXW49_23055	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW49_23060	COG3874	Sporulation protein YtfJ
EXW49_23080	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW49_23090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW49_23105	COG1104	cysteine desulfurase activity
EXW49_23110	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW49_23120	COG1309	transcriptional regulator
EXW49_23125	COG1956	GAF domain-containing protein
EXW49_23130	COG0626	cystathionine gamma-synthase activity
EXW49_23135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW49_23160	COG1595	DNA-templated transcription, initiation
EXW49_23170	COG0110	maltose O-acetyltransferase activity
EXW49_23175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW49_23180	COG0454	-acetyltransferase
EXW49_23185	COG0517	IMP dehydrogenase activity
EXW49_23190	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW49_23205	COG0745	RESPONSE REGULATOR receiver
EXW49_23215	COG0666	response to abiotic stimulus
EXW49_23225	COG1970	mechanosensitive ion channel activity
EXW49_23245	COG1609	Transcriptional regulator
EXW49_23255	COG1605	Chorismate mutase
EXW49_23255	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW49_23260	COG4851	CamS sex pheromone cAM373 precursor
EXW49_23265	COG3118	belongs to the thioredoxin family
EXW49_23275	COG2309	aminopeptidase activity
EXW49_23295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_23300	COG1695	Transcriptional regulator
EXW49_23310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW49_23320	COG1674	ftsk spoiiie
EXW49_23335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW49_23340	COG4848	Belongs to the UPF0354 family
EXW49_23345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_23350	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW49_23355	COG1363	Peptidase, m42
EXW49_23365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_23370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW49_23380	COG0510	thiamine kinase activity
EXW49_23385	COG1523	belongs to the glycosyl hydrolase 13 family
EXW49_23395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW49_23400	COG1349	DNA-binding transcription factor activity
EXW49_23405	COG1187	pseudouridine synthase activity
EXW49_23410	COG2244	polysaccharide biosynthetic process
EXW49_23415	COG2081	HI0933 family
EXW49_23420	COG2814	Major facilitator Superfamily
EXW49_23430	COG3832	glyoxalase III activity
EXW49_23450	COG1329	Transcriptional regulator
EXW49_23475	COG0314	molybdopterin synthase activity
EXW49_23480	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW49_23485	COG0303	'Molybdopterin
EXW49_23490	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW49_23495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW49_23500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW49_23525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW49_23535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW49_23575	COG0495	leucyl-tRNA aminoacylation
EXW49_23580	COG2814	Major facilitator Superfamily
EXW49_23585	COG0475	glutathione-regulated potassium exporter activity
EXW49_23590	COG0490	domain, Protein
EXW49_23595	COG0582	viral genome integration into host DNA
EXW49_23610	COG1136	(ABC) transporter
EXW49_23625	COG1242	4 iron, 4 sulfur cluster binding
EXW49_23630	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW49_23650	COG1794	racemase activity, acting on amino acids and derivatives
EXW49_23665	COG2267	carboxylic ester hydrolase activity
EXW49_23670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW49_23675	COG0671	phosphoesterase, PA-phosphatase related
EXW49_23680	COG0438	transferase activity, transferring glycosyl groups
EXW49_23685	COG0746	molybdenum cofactor guanylyltransferase activity
EXW49_23705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW49_23710	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW49_23750	COG5002	protein histidine kinase activity
EXW49_23755	COG3852	Histidine kinase
EXW49_23760	COG0753	catalase activity
EXW49_23765	COG2267	carboxylic ester hydrolase activity
EXW49_23775	COG1368	sulfuric ester hydrolase activity
EXW49_23785	COG4895	conserved protein (DUF2196)
EXW49_23800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW49_23805	COG1116	anion transmembrane transporter activity
EXW49_23810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW49_23830	COG0494	nUDIX hydrolase
EXW49_23875	COG2076	Multidrug Resistance protein
EXW49_23880	COG2076	Multidrug Resistance protein
EXW49_23885	COG0789	Transcriptional regulator
EXW49_23890	COG1854	S-ribosylhomocysteine lyase activity
EXW49_23900	COG0288	reversible hydration of carbon dioxide
EXW49_23905	COG1271	oxidase subunit
EXW49_23910	COG1294	oxidase, subunit
EXW49_23930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_23960	COG1842	Phage shock protein A
EXW49_23990	COG5002	protein histidine kinase activity
EXW49_23995	COG0745	RESPONSE REGULATOR receiver
EXW49_24020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW49_24025	COG1597	lipid kinase activity
EXW49_24055	COG1136	(ABC) transporter
EXW49_24085	COG5002	protein histidine kinase activity
EXW49_24095	COG0586	Pfam SNARE associated Golgi protein
EXW49_24100	COG3963	phosphatidate phosphatase activity
EXW49_24110	COG0577	efflux transmembrane transporter activity
EXW49_24115	COG1136	(ABC) transporter
EXW49_24120	COG3708	Transcriptional regulator
EXW49_24120	COG2207	Transcriptional regulator
EXW49_24130	COG1131	(ABC) transporter
EXW49_24140	COG5658	integral membrane protein
EXW49_24145	COG0640	Transcriptional regulator
EXW49_24150	COG0745	RESPONSE REGULATOR receiver
EXW49_24155	COG2205	protein histidine kinase activity
EXW49_24160	COG0577	efflux transmembrane transporter activity
EXW49_24165	COG0577	efflux transmembrane transporter activity
EXW49_24170	COG1136	(ABC) transporter
EXW49_24175	COG0577	efflux transmembrane transporter activity
EXW49_24190	COG2188	Transcriptional regulator
EXW49_24210	COG3964	amidohydrolase
EXW49_24230	COG4948	Mandelate Racemase Muconate Lactonizing
EXW49_24235	COG0318	PFAM AMP-dependent synthetase and ligase
EXW49_24240	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW49_24245	COG0596	Alpha beta hydrolase
EXW49_24250	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW49_24255	COG1169	isochorismate synthase
EXW49_24260	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW49_24265	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW49_24270	COG1278	Cold shock
EXW49_24290	COG0058	SHG alpha-glucan phosphorylase activity
EXW49_24300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW49_24305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW49_24310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW49_24335	COG2801	Transposase and inactivated derivatives
EXW49_24475	COG1285	pathogenesis
EXW49_24480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW49_24490	COG0166	Belongs to the GPI family
EXW49_24500	COG2155	Conserved Protein
EXW49_24505	COG1098	S1 RNA binding domain
EXW49_24510	COG0436	Aminotransferase
EXW49_24515	COG1522	sequence-specific DNA binding
EXW49_24520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW49_24525	COG2267	carboxylic ester hydrolase activity
EXW49_24535	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW49_24550	COG5018	Exonuclease
EXW49_24555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW49_24580	COG2801	Transposase and inactivated derivatives
EXW49_24590	COG2050	protein possibly involved in aromatic compounds catabolism
EXW49_24600	COG1268	BioY protein
EXW49_24605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW49_24610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW49_24620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW49_24625	COG3584	3D domain protein
EXW49_24640	COG1252	NADH dehydrogenase
EXW49_24645	COG0492	ferredoxin-NADP+ reductase activity
EXW49_24650	COG3708	Transcriptional regulator
EXW49_24665	COG1683	Conserved Protein
EXW49_24690	COG0316	Belongs to the HesB IscA family
EXW49_24695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW49_24700	COG4844	belongs to the
EXW49_24705	COG1252	NADH dehydrogenase
EXW49_24710	COG2274	protein secretion by the type I secretion system
EXW49_24715	COG0390	transport system, permease component
EXW49_24720	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW49_24745	COG4837	Protein of unknown function (DUF1462)
EXW49_24750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW49_24770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW49_24775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW49_24815	COG1136	(ABC) transporter
EXW49_24835	COG1132	(ABC) transporter
EXW49_24855	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW49_24865	COG0647	UMP catabolic process
EXW49_24875	COG2445	Protein of unknown function DUF86
EXW49_24880	COG1494	fructose-1,6-bisphosphatase
EXW49_24895	COG4470	Protein conserved in bacteria
EXW49_24905	COG0789	Transcriptional regulator
EXW49_24910	COG4377	Putative membrane peptidase family (DUF2324)
EXW49_24930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW49_24935	COG0739	heme binding
EXW49_24945	COG3377	Domain of unknown function (DUF1805)
EXW49_24950	COG0737	Belongs to the 5'-nucleotidase family
EXW49_24955	COG2801	Transposase and inactivated derivatives
EXW49_24965	COG0719	Fe-S assembly protein
EXW49_24970	COG0822	iron-sulfur transferase activity
EXW49_24975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW49_24980	COG0719	Fe-S assembly protein
EXW49_24985	COG0396	ATPase activity
EXW49_24990	COG1464	Belongs to the NlpA lipoprotein family
EXW49_24995	COG1464	Belongs to the NlpA lipoprotein family
EXW49_25000	COG2011	ABC-type metal ion transport system permease component
EXW49_25015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW49_25020	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW49_25025	COG0509	glycine decarboxylation via glycine cleavage system
EXW49_25030	COG1393	Belongs to the ArsC family
EXW49_25065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW49_25070	COG1960	acyl-CoA dehydrogenase activity
EXW49_25075	COG0183	Belongs to the thiolase family
EXW49_25080	COG1024	Enoyl-CoA hydratase
EXW49_25080	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW49_25090	COG1686	Belongs to the peptidase S11 family
EXW49_25095	COG0506	proline dehydrogenase activity
EXW49_25105	COG0011	TIGRFAM Protein of
EXW49_25110	COG0840	transmembrane signaling receptor activity
EXW49_25125	COG2814	Major facilitator Superfamily
EXW49_25130	COG0531	amino acid
EXW49_25155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW49_25280	COG0586	Pfam SNARE associated Golgi protein
EXW49_25290	COG1376	ErfK ybiS ycfS ynhG family protein
EXW49_25295	COG0745	RESPONSE REGULATOR receiver
EXW49_25300	COG5002	protein histidine kinase activity
EXW49_25310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW49_25320	COG0840	transmembrane signaling receptor activity
EXW49_25325	COG0840	transmembrane signaling receptor activity
EXW49_25330	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW49_25335	COG3227	Zinc metalloprotease (Elastase)
EXW49_25340	COG1741	Belongs to the pirin family
EXW49_25355	COG0475	glutathione-regulated potassium exporter activity
EXW49_25360	COG0490	domain, Protein
EXW49_25365	COG1115	amino acid carrier protein
EXW49_25370	COG0783	Belongs to the Dps family
EXW49_25380	COG2318	DinB family
EXW49_25385	COG1611	Belongs to the LOG family
EXW49_25395	COG1528	Iron-storage protein
EXW49_25400	COG2311	Membrane
EXW49_25405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_25410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_25415	COG1115	amino acid carrier protein
EXW49_25420	COG1115	amino acid carrier protein
EXW49_25425	COG2910	NAD(P)H-binding
EXW49_25455	COG0656	L-ascorbic acid biosynthetic process
EXW49_25460	COG2814	Major facilitator Superfamily
EXW49_25465	COG1733	regulation of RNA biosynthetic process
EXW49_25475	COG1252	NADH dehydrogenase
EXW49_25495	COG0840	transmembrane signaling receptor activity
EXW49_25495	COG3290	protein histidine kinase activity
EXW49_25525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW49_25540	COG1522	sequence-specific DNA binding
EXW49_25545	COG0288	reversible hydration of carbon dioxide
EXW49_25550	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW49_25555	COG2233	PERMEase
EXW49_25565	COG2801	Transposase and inactivated derivatives
EXW49_25605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW49_25615	COG0557	exoribonuclease II activity
EXW49_25620	COG1647	Serine aminopeptidase, S33
EXW49_25625	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW49_25630	COG1346	cytolysis
EXW49_25645	COG0148	phosphopyruvate hydratase activity
EXW49_25655	COG0149	triose-phosphate isomerase activity
EXW49_25660	COG0126	phosphoglycerate kinase activity
EXW49_25665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW49_25680	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW49_25715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW49_25730	COG2323	membrane
EXW49_25740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW49_25745	COG1481	regulation of sporulation
EXW49_25750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW49_25755	COG1660	Displays ATPase and GTPase activities
EXW49_25760	COG1051	belongs to the nudix hydrolase family
EXW49_25770	COG0492	ferredoxin-NADP+ reductase activity
EXW49_25775	COG0457	Tetratricopeptide repeat
EXW49_25780	COG0110	maltose O-acetyltransferase activity
EXW49_25785	COG0546	phosphoglycolate phosphatase activity
EXW49_25790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW49_25795	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW49_25800	COG1950	PFAM Membrane protein of
EXW49_25805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW49_25825	COG0789	Transcriptional regulator
EXW49_25860	COG0583	DNA-binding transcription factor activity
EXW49_25865	COG0789	Transcriptional regulator
EXW49_25870	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW49_25875	COG0488	(ABC) transporter
EXW49_25885	COG1132	(ABC) transporter
EXW49_25890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW49_25895	COG3409	Peptidoglycan-binding domain 1 protein
EXW49_25895	COG0793	Belongs to the peptidase S41A family
EXW49_25900	COG2177	Part of the ABC transporter FtsEX involved in
EXW49_25905	COG2884	Cell division ATP-binding protein ftsE
EXW49_25945	COG1278	Cold shock
EXW49_25950	COG1040	competence protein
EXW49_25955	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW49_25960	COG1388	LysM domain
EXW49_25960	COG0791	NLP P60 protein
EXW49_25965	COG1733	regulation of RNA biosynthetic process
EXW49_25970	COG1307	EDD domain protein, DegV family
EXW49_25975	COG1739	Uncharacterized protein family UPF0029
EXW49_25980	COG1316	TRANSCRIPTIONal
EXW49_25985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW49_25990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW49_25995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW49_26005	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW49_26005	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW49_26025	COG1486	melibiose metabolic process
EXW49_26030	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW49_26035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW49_26040	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW49_26055	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW49_26065	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW49_26070	COG1301	dicarboxylic acid transport
EXW49_26090	COG1511	domain protein
EXW49_26095	COG0583	DNA-binding transcription factor activity
EXW49_26100	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW49_26105	COG1271	oxidase subunit
EXW49_26110	COG1294	oxidase, subunit
EXW49_26115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW49_26120	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW49_26125	COG1620	l-lactate permease
EXW49_26135	COG2389	metal-binding protein
EXW49_26150	COG1368	sulfuric ester hydrolase activity
EXW49_26160	COG0791	NLP P60 protein
EXW49_26160	COG1388	LysM domain
EXW49_26165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW49_26175	COG1215	transferase activity, transferring glycosyl groups
EXW49_26180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW49_26190	COG1388	LysM domain
EXW49_26190	COG3584	3D domain protein
EXW49_26215	COG4715	Zinc finger, swim domain protein
EXW49_26220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW49_26260	COG0577	efflux transmembrane transporter activity
EXW49_26265	COG1136	(ABC) transporter
EXW49_26290	COG5002	protein histidine kinase activity
EXW49_26290	COG3850	Histidine kinase
EXW49_26295	COG0745	RESPONSE REGULATOR receiver
EXW49_26310	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW49_26325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW49_26340	COG0110	maltose O-acetyltransferase activity
EXW49_26365	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EXW49_26370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW49_26375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW49_26380	COG4464	protein tyrosine phosphatase activity
EXW49_26385	COG0489	protein tyrosine kinase activity
EXW49_26390	COG3944	biosynthesis protein
EXW49_26395	COG0489	protein tyrosine kinase activity
EXW49_26415	COG1609	Transcriptional regulator
EXW49_26435	COG0739	heme binding
EXW49_26450	COG3279	Response regulator of the LytR AlgR family
EXW49_26455	COG2385	sporulation resulting in formation of a cellular spore
EXW49_26470	COG4836	Membrane
EXW49_26475	COG1007	ATP synthesis coupled electron transport
EXW49_26480	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW49_26485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW49_26490	COG0713	ATP synthesis coupled electron transport
EXW49_26495	COG0839	Belongs to the complex I subunit 6 family
EXW49_26505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW49_26510	COG0649	NAD binding
EXW49_26515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW49_26520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW49_26525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW49_26530	COG5001	Diguanylate cyclase
EXW49_26530	COG3300	MHYT domain
EXW49_26545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW49_26550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW49_26555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW49_26560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW49_26565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW49_26570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW49_26580	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW49_26605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW49_26615	COG0698	ribose 5-phosphate isomerase
EXW49_26625	COG2190	(PTS) system
EXW49_26630	COG2259	Doxx family
EXW49_26635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW49_26645	COG1971	Probably functions as a manganese efflux pump
EXW49_26650	COG0009	L-threonylcarbamoyladenylate synthase
EXW49_26665	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW49_26670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW49_26675	COG1435	thymidine kinase activity
EXW49_26690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW49_26700	COG1494	fructose-1,6-bisphosphatase
EXW49_26720	COG4821	SIS domain
EXW49_26725	COG0504	CTP synthase activity
EXW49_26730	COG3343	RNA polymerase activity
EXW49_26740	COG1960	acyl-CoA dehydrogenase activity
EXW49_26745	COG1960	acyl-CoA dehydrogenase activity
EXW49_26750	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW49_26755	COG0183	Belongs to the thiolase family
EXW49_26760	COG0247	lactate metabolic process
EXW49_26760	COG2181	nitrate reductase activity
EXW49_26765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW49_26770	COG4294	response to UV
EXW49_26775	COG5001	Diguanylate cyclase
EXW49_26775	COG3300	MHYT domain
EXW49_26790	COG3227	Zinc metalloprotease (Elastase)
EXW49_26795	COG2197	response regulator
EXW49_26800	COG4585	Histidine kinase
EXW49_26805	COG0842	Transport permease protein
EXW49_26810	COG1131	(ABC) transporter
EXW49_26815	COG0024	Methionine aminopeptidase
EXW49_26825	COG2234	aminopeptidase activity
EXW49_26845	COG4506	Protein conserved in bacteria
EXW49_26850	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW49_26865	COG0010	Belongs to the arginase family
EXW49_26870	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW49_26875	COG2814	Major facilitator Superfamily
EXW49_26880	COG0789	Transcriptional regulator
EXW49_26885	COG0584	glycerophosphoryl diester phosphodiesterase
EXW49_26890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW49_26900	COG1994	Peptidase M50
EXW49_26910	COG1078	dGTPase activity
EXW49_26915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW49_26920	COG1120	ATPase activity
EXW49_26925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_26930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW49_26935	COG4844	belongs to the
EXW49_26950	COG0280	phosphate acetyltransferase
EXW49_26955	COG3253	May function as heme-dependent peroxidase
EXW49_26965	COG3773	Cell wall hydrolase
EXW49_26975	COG2363	Small membrane protein
EXW49_26985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW49_26990	COG2233	PERMEase
EXW49_26995	COG0561	phosphatase activity
EXW49_27000	COG2814	Major facilitator Superfamily
EXW49_27005	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW49_27010	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW49_27015	COG1131	(ABC) transporter
EXW49_27020	COG2755	lipolytic protein G-D-S-L family
EXW49_27025	COG1609	Transcriptional regulator
EXW49_27035	COG0460	homoserine dehydrogenase
EXW49_27040	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW49_27045	COG2873	o-acetylhomoserine
EXW49_27055	COG1011	Hydrolase
EXW49_27060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW49_27070	COG2197	response regulator
EXW49_27075	COG4585	Histidine kinase
EXW49_27075	COG2203	Gaf domain
EXW49_27080	COG0351	phosphomethylpyrimidine kinase
EXW49_27085	COG3706	GGDEF domain
EXW49_27090	COG2879	small protein
EXW49_27095	COG1966	Carbon starvation protein
EXW49_27100	COG3279	Response regulator of the LytR AlgR family
EXW49_27105	COG0477	Major facilitator Superfamily
EXW49_27135	COG0840	transmembrane signaling receptor activity
EXW49_27145	COG1607	acyl-coa hydrolase
EXW49_27150	COG1216	Glycosyl transferase, family 2
EXW49_27160	COG1216	Glycosyl transferase, family 2
EXW49_27170	COG4485	Bacterial membrane protein, YfhO
EXW49_27175	COG0463	Glycosyl transferase, family 2
EXW49_27185	COG1309	transcriptional regulator
EXW49_27190	COG0488	(ABC) transporter
EXW49_27195	COG1309	transcriptional regulator
EXW49_27200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW49_27205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW49_27205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW49_27210	COG0628	permease
EXW49_27220	COG1380	Effector of murein hydrolase LrgA
EXW49_27225	COG3279	Response regulator of the LytR AlgR family
EXW49_27230	COG3275	phosphorelay sensor kinase activity
EXW49_27235	COG2814	Major facilitator Superfamily
EXW49_27240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW49_27245	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW49_27255	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW49_27280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW49_27285	COG1272	protein, Hemolysin III
EXW49_27310	COG1164	Oligoendopeptidase f
EXW49_27320	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW49_27330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW49_27335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW49_27340	COG4853	Protein conserved in bacteria
EXW49_27350	COG5002	protein histidine kinase activity
EXW49_27355	COG0745	RESPONSE REGULATOR receiver
EXW49_27385	COG0305	Participates in initiation and elongation during chromosome replication
EXW49_27390	COG0359	binds to the 23S rRNA
EXW49_27395	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW49_27400	COG4241	membrane
EXW49_27410	COG0629	single-stranded DNA binding
EXW49_27415	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW49_27420	COG0012	GTP binding
EXW49_27425	COG4481	Protein conserved in bacteria
EXW49_27430	COG0668	transmembrane transport
EXW49_27440	COG1475	DNA binding
EXW49_27445	COG1192	Involved in chromosome partitioning
EXW49_27450	COG1475	DNA binding
EXW49_27455	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW49_27460	COG0445	tRNA wobble uridine modification
EXW49_27465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW49_27470	COG1847	R3H domain protein
EXW49_27475	COG0706	membrane insertase activity
EXW49_27480	COG0594	ribonuclease P activity
EXW49_27485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW49_27490	COG1484	DNA-dependent DNA replication
EXW49_27540	COG0756	dUTP diphosphatase activity
EXW49_27585	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
EXW49_27620	COG5484	DNA packaging
EXW49_27625	COG1783	phage Terminase large subunit
EXW49_27630	COG5518	Phage portal protein
EXW49_27635	COG2369	cell adhesion
EXW49_27640	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EXW49_27645	COG4653	Phage capsid family
EXW49_27800	COG1396	sequence-specific DNA binding
EXW49_27815	COG1396	sequence-specific DNA binding
EXW49_27825	COG3646	Phage regulatory protein
EXW49_27845	COG0419	ATPase involved in DNA repair
EXW49_27875	COG0741	lytic transglycosylase activity
EXW49_27885	COG1674	ftsk spoiiie
EXW49_27900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW49_27925	COG5002	protein histidine kinase activity
EXW49_27945	COG2801	Transposase and inactivated derivatives
EXW49_27960	COG0024	Methionine aminopeptidase
EXW49_28065	COG0791	NLP P60 protein
EXW49_28065	COG3883	PFAM NLP P60 protein
EXW49_28130	COG2002	toxin-antitoxin pair type II binding
EXW49_28135	COG2318	DinB family
EXW49_28140	COG2378	regulation of single-species biofilm formation
EXW49_28155	COG0582	viral genome integration into host DNA
EXW49_28170	COG0840	transmembrane signaling receptor activity
EXW49_28255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW49_28300	COG2031	fatty acid transporter
EXW49_28320	COG0463	Glycosyl transferase, family 2
EXW49_28325	COG0463	Glycosyl transferase, family 2
EXW49_28330	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW49_28335	COG1086	Polysaccharide biosynthesis protein
EXW49_28340	COG1088	dTDP-glucose 4,6-dehydratase activity
EXW49_28345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW49_28350	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW49_28365	COG2089	acid synthase
EXW49_28370	COG4641	Protein conserved in bacteria
EXW49_28425	COG0745	RESPONSE REGULATOR receiver
EXW49_28430	COG2205	protein histidine kinase activity
EXW49_28435	COG1136	(ABC) transporter
EXW49_28440	COG0577	efflux transmembrane transporter activity
EXW49_28450	COG2002	toxin-antitoxin pair type II binding
EXW49_28460	COG1923	regulation of RNA biosynthetic process
EXW49_28505	COG2814	Major facilitator Superfamily
EXW49_28560	COG0640	Transcriptional regulator
EXW49_28600	COG1733	regulation of RNA biosynthetic process
EXW49_28610	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EXW49_28620	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXW49_28620	COG2918	glutathione biosynthetic process
EXW49_28640	COG0583	DNA-binding transcription factor activity
EXW49_28700	COG4977	sequence-specific DNA binding
EXW49_28715	COG0083	homoserine kinase activity
EXW49_28735	COG1309	transcriptional regulator
EXW49_28740	COG2814	Major facilitator Superfamily
EXW49_28790	COG0814	amino acid
EXW49_28795	COG0697	spore germination
EXW49_28805	COG1760	l-serine dehydratase
EXW49_28810	COG1760	l-serine dehydratase
EXW49_28815	COG0814	amino acid
EXW49_28835	COG0662	Cupin 2, conserved barrel domain protein
EXW49_28850	COG0697	spore germination
EXW49_28880	COG0110	maltose O-acetyltransferase activity
EXW49_28895	COG1396	sequence-specific DNA binding
EXW49_28915	COG0840	transmembrane signaling receptor activity
EXW49_28920	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW49_28960	COG4974	Belongs to the 'phage' integrase family
EXW49_29010	COG1263	PTS System
EXW49_29010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW49_29015	COG0697	spore germination
EXW49_29030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW49_29035	COG2239	Acts as a magnesium transporter
EXW49_29045	COG3409	Peptidoglycan-binding domain 1 protein
EXW49_29045	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW49_29055	COG1725	Transcriptional regulator
EXW49_29060	COG1131	(ABC) transporter
EXW49_29120	COG1329	Transcriptional regulator
EXW49_29180	COG4176	ABC-type proline glycine betaine transport system permease component
EXW49_29185	COG4175	Glycine betaine
EXW49_29185	COG0517	IMP dehydrogenase activity
EXW49_29230	COG0582	viral genome integration into host DNA
EXW49_29300	COG2801	Transposase and inactivated derivatives
EXW49_29400	COG2755	lipolytic protein G-D-S-L family
EXW49_29400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW49_29435	COG0745	RESPONSE REGULATOR receiver
EXW49_29455	COG2720	vancomycin resistance protein
EXW49_29515	COG0457	Tetratricopeptide repeat
EXW49_29580	COG3800	Transcriptional regulator
EXW49_29580	COG1396	sequence-specific DNA binding
EXW49_29600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW49_29680	COG0776	regulation of translation
EXW49_29685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW49_29735	COG0367	asparagine synthase
EXW49_29760	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW49_29785	COG0739	heme binding
EXW49_29870	COG0542	response to heat
EXW49_29880	COG3397	chitin binding
EXW49_29985	COG3220	belongs to the UPF0276 family
EXW49_29990	COG1404	Belongs to the peptidase S8 family
EXW49_30000	COG1132	(ABC) transporter
EXW49_30010	COG1404	Belongs to the peptidase S8 family
EXW49_30020	COG2814	Major facilitator Superfamily
EXW49_30030	COG2234	aminopeptidase activity
EXW49_30040	COG0363	glucosamine-6-phosphate deaminase activity
EXW49_30055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW49_30060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW49_30065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW49_30075	COG0456	acetyltransferase