locus-tag class description B7492_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) B7492_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B7492_00015 ENOG410848D S4 domain protein YaaA B7492_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) B7492_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B7492_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) B7492_00075 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) B7492_00080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) B7492_00100 ENOG4105ZMH deoxynucleoside kinase B7492_00110 ENOG4105GTG Isochorismatase B7492_00115 ENOG4108Z6B deaminase B7492_00125 ENOG4105C6E dna polymerase iii B7492_00130 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) B7492_00135 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) B7492_00145 ENOG41067KS pro-sigma K processing B7492_00180 ENOG4105CXN decarboxylase B7492_00185 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) B7492_00190 ENOG4105FA2 dna polymerase iii B7492_00195 ENOG4105MA4 psp1 domain protein B7492_00205 ENOG41060K3 Methyltransferase B7492_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) B7492_00220 ENOG4105KRN Transcriptional regulator, abrb family B7492_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) B7492_00230 ENOG4105F8V Hydrolase, tatD family B7492_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) B7492_00240 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) B7492_00245 ENOG4105XFA sporulation peptidase YabG B7492_00250 ENOG4105W42 Veg protein B7492_00260 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) B7492_00265 ENOG4105DFT pur operon repressor B7492_00270 ENOG4105KME endoribonuclease L-psp B7492_00280 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) B7492_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase B7492_00300 ENOG4108JA2 transcriptioN-repair coupling factor B7492_00305 ENOG4108M14 stage v sporulation protein t B7492_00315 ENOG4108IY2 MazG family B7492_00320 ENOG41082I2 s4 domain protein B7492_00325 ENOG4105VYY sporulation protein yabp B7492_00340 ENOG41060GV RNA binding s1 domain protein B7492_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) B7492_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase B7492_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) B7492_00380 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) B7492_00385 ENOG4105C6T cysteine synthase B7492_00390 ENOG4105CRQ synthase (Component I) B7492_00395 ENOG4105DDQ anthranilate synthase B7492_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 B7492_00405 ENOG4105EEI dihydropteroate synthase B7492_00410 ENOG4105KRF dihydroneopterin aldolase B7492_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase B7492_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) B7492_00430 ENOG4105CRK lysyL-tRNA synthetase B7492_00520 ENOG4108Z0C Uvrb UvrC protein B7492_00535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) B7492_00540 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) B7492_00545 ENOG4105CTP PilT protein domain protein B7492_00550 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) B7492_00560 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) B7492_00565 ENOG4105D7W serine acetyltransferase B7492_00570 ENOG4105C8N cysteinyl-tRNA synthetase B7492_00580 ENOG4105C2N RNA methyltransferase TrmH family group 3 B7492_00585 ENOG4105M0M Tetracycline resistance protein B7492_00590 ENOG4105QIV RNA polymerase B7492_00605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) B7492_00615 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) B7492_00620 ENOG4108VZM 50s ribosomal protein L10 B7492_00625 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) B7492_00630 ENOG4107Y49 methyltransferase B7492_00635 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B7492_00640 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B7492_00645 ENOG4105XPM ribosomal protein B7492_00655 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) B7492_00660 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) B7492_00665 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) B7492_00680 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) B7492_00690 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity B7492_00695 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) B7492_00700 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) B7492_00710 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) B7492_00715 ENOG41082SA 50s ribosomal protein l29 B7492_00720 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal B7492_00725 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) B7492_00730 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) B7492_00735 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits B7492_00745 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) B7492_00750 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) B7492_00755 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) B7492_00765 ENOG4105VPB 50S ribosomal protein L30 B7492_00770 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) B7492_00775 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B7492_00785 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B7492_00795 ENOG41067V7 50S ribosomal protein L36 B7492_00805 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) B7492_00825 ENOG4108JJB ABC transporter B7492_00830 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) B7492_00835 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B7492_00840 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) B7492_00845 ENOG4108UJD 30S ribosomal protein S9 B7492_00860 ENOG4105D1F ATP-binding protein B7492_00875 ENOG4108NMV polysaccharide deacetylase B7492_00955 ENOG4105C8B TIGR00159 family B7492_00960 ENOG4107U5W ybbr family B7492_00965 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) B7492_00990 ENOG4108PSK reductase B7492_01005 ENOG4105D01 (LipO)protein B7492_01010 ENOG4105EE1 crotonyl-CoA reductase B7492_01020 ENOG4105IQ5 FAD linked oxidase domain protein B7492_01035 ENOG4105C2C drug resistance transporter, Bcr CflA B7492_01055 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B7492_01060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7492_01065 ENOG4105C3U ABC transporter B7492_01070 ENOG4108JQ7 (ABC) transporter B7492_01100 ENOG4108J59 Extracellular solute-binding protein, family 5 B7492_01105 ENOG4108J59 Extracellular solute-binding protein, family 5 B7492_01115 ENOG4105II7 pyrroline-5-carboxylate reductase B7492_01120 ENOG4106Z1T Nicotinamide Mononucleotide Transporter B7492_01130 ENOG4105E0C molybdate abc transporter B7492_01135 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein B7492_01140 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family B7492_01165 ENOG4105F6E Acyl-transferase B7492_01185 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) B7492_01200 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) B7492_01220 ENOG4105C5H ABC transporter B7492_01230 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein B7492_01260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7492_01265 ENOG4105C3U ABC transporter B7492_01270 ENOG4108JQ7 (ABC) transporter B7492_01275 ENOG410667J hydrolase B7492_01305 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase B7492_01310 ENOG4105ERH Fumarylacetoacetate hydrolase B7492_01320 ENOG4105CUB amino acid B7492_01325 ENOG4108SC4 )-transporter B7492_01330 ENOG4105CPF Cell wall formation (By similarity) B7492_01335 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) B7492_01355 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) B7492_01360 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein B7492_01365 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B7492_01375 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) B7492_01480 ENOG4105K8N protein family UPF0079, ATPase B7492_01485 ENOG41072GX Peptidase M22 Glycoprotease B7492_01490 ENOG410801F ribosomal-protein-alanine acetyltransferase B7492_01500 ENOG4105C5H ABC transporter B7492_01515 ENOG4108TYN CAAX amino terminal protease family protein B7492_01520 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) B7492_01525 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) B7492_01530 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) B7492_01535 ENOG4105C7N Xanthine uracil vitamin C permease B7492_01545 ENOG4105BZU Histidine kinase B7492_01570 ENOG4107ZXU DSBA oxidoreductase B7492_01590 ENOG4108V4B ThiJ pfpI B7492_01655 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7492_01675 ENOG4105SX7 Transporter B7492_01705 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) B7492_01710 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit B7492_01715 ENOG4105C83 adenylosuccinate lyase B7492_01720 ENOG4105C8V SAICAR synthetase B7492_01725 ENOG4105VR9 phosphoribosylformylglycinamidine synthase B7492_01730 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I B7492_01735 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii B7492_01745 ENOG4105CXB phosphoribosylaminoimidazole synthetase B7492_01750 ENOG4108V3E phosphoribosylglycinamide formyltransferase B7492_01755 ENOG4105DC1 bifunctional purine biosynthesis protein purh B7492_01760 ENOG4105C12 Phosphoribosylglycinamide synthetase B7492_01785 ENOG4105C4R Atp-dependent dna helicase B7492_01790 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) B7492_01805 ENOG4105C26 Dehydrogenase B7492_01810 ENOG4108W2Y isochorismatase B7492_01820 ENOG4108UMI ABC transporter, permease B7492_01825 ENOG4105D01 (LipO)protein B7492_01845 ENOG41067TZ transcriptional regulator, MarR family B7492_01860 ENOG4108IMY Transcriptional regulator B7492_01890 ENOG4106CVF DNA replication protein B7492_02030 ENOG4105CAR Terminase, large subunit B7492_02040 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B7492_02150 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B7492_02155 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) B7492_02160 ENOG4105CBD Diacylglycerol kinase B7492_02170 ENOG4108JPW Aminotransferase B7492_02180 ENOG4105C26 Dehydrogenase B7492_02185 ENOG4105KPY Small multidrug resistance protein B7492_02205 ENOG4105D9N nucleoside B7492_02210 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B7492_02220 ENOG4105BZU Histidine kinase B7492_02230 ENOG4108W15 Protein of unknown function (DUF1456) B7492_02245 ENOG4105DTQ mandelate racemase muconate lactonizing B7492_02255 ENOG4105DFD Na H antiporter B7492_02275 ENOG4105D3R alkyl hydroperoxide reductase B7492_02280 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) B7492_02285 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) B7492_02290 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase B7492_02295 ENOG4105EHG Permease protein B7492_02300 ENOG4105DQ5 transport system permease protein B7492_02305 ENOG4108V5C ABC transporter B7492_02315 ENOG4105CAY ferredoxin--nadp reductase B7492_02330 ENOG4106UIA B7492_02335 ENOG4106UIA B7492_02350 ENOG4105BZU Histidine kinase B7492_02370 ENOG410756H nucleotidyltransferase B7492_02380 ENOG4105D2S major facilitator superfamily B7492_02400 ENOG4105EAB amino acid AbC transporter B7492_02410 ENOG4105C8Q Methyl-accepting chemotaxis B7492_02415 ENOG4105DNP FAD linked oxidase domain protein B7492_02425 ENOG4105CI1 PTS System B7492_02440 ENOG4105C9U ATP-dependent DNA helicase RecQ B7492_02445 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase B7492_02450 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) B7492_02455 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter B7492_02475 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component B7492_02480 ENOG4105D2X ABC transporter substrate-binding protein B7492_02490 ENOG4105C5H ABC transporter B7492_02515 ENOG41062JF Transcriptional regulator B7492_02530 ENOG4105DEU major facilitator superfamily B7492_02560 ENOG4108N0M stress protein B7492_02565 ENOG4106FN3 tellurium resistance protein B7492_02570 ENOG4106FN3 tellurium resistance protein B7492_02575 ENOG4107TS3 membrane protein, TerC B7492_02580 ENOG4108TTB tellurium resistance protein B7492_02600 ENOG4105KJF protein tyrosine phosphatase B7492_02610 ENOG4107U9T Pfam:Ribonuclease_BN B7492_02615 ENOG4105C59 p-type ATPase B7492_02620 ENOG4108IPJ Membrane B7492_02640 ENOG4107ZTW SNARE associated Golgi B7492_02655 ENOG410606W general stress protein B7492_02660 ENOG4105UPD Calcium Proton B7492_02700 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B7492_02710 ENOG4108JUB Transcriptional regulator B7492_02720 ENOG4108IQI permease B7492_02745 ENOG4105CSV Glutaminase B7492_02760 ENOG4108A04 Beta-lactamase B7492_02780 ENOG4107R51 Glycosyl transferase, family 2 B7492_02785 ENOG4107QQG Dehydrogenase B7492_02790 ENOG4105C3I Nad-dependent epimerase dehydratase B7492_02795 ENOG410838F Glycosyl transferase family 2 B7492_02810 ENOG4105F1A Pyruvate formate-lyase B7492_02815 ENOG4108QBV Monogalactosyldiacylglycerol synthase B7492_02830 ENOG4105CI2 imidazolone-5-propionate hydrolase B7492_02835 ENOG4105ECP epimerase B7492_02865 ENOG41067AE Membrane-bound metal-dependent hydrolase B7492_02870 ENOG4105CEN a g-specific adenine glycosylase B7492_02895 ENOG4105BZ1 (ABC) transporter B7492_02900 ENOG4107NBY Membrane B7492_02905 ENOG4105CBC glutamate synthase B7492_02915 ENOG4108IUW ABC transporter B7492_02935 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B7492_02940 ENOG4105G5W regulator Fur family B7492_03060 ENOG4108JQC penicillin-binding protein 1A B7492_03065 ENOG4107ZQN disulfide bond B7492_03075 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) B7492_03085 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) B7492_03090 ENOG4105BZU Histidine kinase B7492_03095 ENOG4105CYN Serine protein kinase B7492_03100 ENOG4106AKX UPF0229 protein B7492_03120 ENOG4105DZ6 Band 7 protein B7492_03130 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism B7492_03135 ENOG4108V9W transcriptional regulatory protein B7492_03140 ENOG4105D4T Citrate transporter B7492_03170 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B7492_03175 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B7492_03180 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component B7492_03185 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component B7492_03190 ENOG4105BZ7 extracellular solute-binding protein family 1 B7492_03195 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) B7492_03200 ENOG4108STX response regulator B7492_03205 ENOG4105US7 Histidine kinase B7492_03230 ENOG4108MRH transcriptional regulatory protein B7492_03240 ENOG4105C6K Malic enzyme B7492_03250 ENOG4108UZ3 Transporter B7492_03255 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7492_03270 ENOG4105BZU Histidine kinase B7492_03275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_03280 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B7492_03285 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B7492_03290 ENOG4108JB9 formate dehydrogenase B7492_03310 ENOG4105CUB amino acid B7492_03325 ENOG4105C59 p-type ATPase B7492_03330 ENOG4105DAP Nicotinate phosphoribosyltransferase B7492_03360 ENOG41073R8 VanW family B7492_03365 ENOG4108KGH TRANSCRIPTIONal B7492_03370 ENOG4105D9N nucleoside B7492_03375 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase B7492_03380 ENOG4105C37 (CBS) domain B7492_03385 ENOG4108IJ0 Aspartate ammonia-lyase B7492_03390 ENOG4105DAA L-lactate B7492_03395 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B7492_03415 ENOG4105DUX Transporter B7492_03420 ENOG4108MES Periplasmic binding protein B7492_03425 ENOG4105DQ5 transport system permease protein B7492_03430 ENOG4108IHU transport system permease protein B7492_03435 ENOG4105E0A ABC, transporter B7492_03440 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) B7492_03450 ENOG4105EXW epimerase dehydratase B7492_03460 ENOG4107T89 von Willebrand factor, type A B7492_03465 ENOG4105GMT ATPase associated with various cellular activities aaa_5 B7492_03470 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B7492_03480 ENOG4105BZU Histidine kinase B7492_03485 ENOG4105D5Q Arginine ornithine antiporter B7492_03490 ENOG4107414 GntR family transcriptional regulator B7492_03495 ENOG4105C5Y PTS System B7492_03500 ENOG4105CG3 alpha amylase, catalytic region B7492_03515 ENOG4105E1K spore germination protein B7492_03520 ENOG4108XG2 Histidine kinase B7492_03525 ENOG4105WH1 Two component transcriptional regulator luxr family B7492_03530 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin B7492_03545 ENOG4105CRN Aminoglycoside phosphotransferase B7492_03550 ENOG4105BZG amino acid carrier protein B7492_03555 ENOG4105CDA abc transporter atp-binding protein B7492_03560 ENOG4105CT1 (ABC) transporter B7492_03565 ENOG4105EAD ABC transporter B7492_03570 ENOG4105DRP amino acid AbC transporter B7492_03575 ENOG4108IQI permease B7492_03605 ENOG4105D29 Helix-turn-helix type 11 domain protein B7492_03610 ENOG4105NAE bifunctional deaminase-reductase domain protein B7492_03615 ENOG4105BZU Histidine kinase B7492_03635 ENOG41068KF Universal stress protein B7492_03645 ENOG4105CXY transporter B7492_03650 ENOG41067TZ transcriptional regulator, MarR family B7492_03655 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7492_03660 ENOG4105ETE Transcriptional regulator (LacI family B7492_03665 ENOG4108RVA ribokinase B7492_03670 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) B7492_03675 ENOG4105C2J ABC transporter B7492_03680 ENOG4105CNN ABC, transporter B7492_03685 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator B7492_03690 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) B7492_03710 ENOG4105C6X Major Facilitator B7492_03755 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B7492_03760 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B7492_03765 ENOG41069ER domain protein B7492_03770 ENOG4105VZ8 Transcriptional regulator B7492_03775 ENOG4107D63 B7492_03790 ENOG4105DUX Transporter B7492_03810 ENOG4105C85 amino acid B7492_03815 ENOG4105C7N Xanthine uracil vitamin C permease B7492_03835 ENOG4105MA6 gCN5-related N-acetyltransferase B7492_03865 ENOG4105CCU oxidase (Subunit III) B7492_03870 ENOG4105BZ9 Cytochrome C oxidase, subunit I B7492_03875 ENOG4105E2S oxidase) subunit II B7492_03880 ENOG4108IQI permease B7492_03895 ENOG4106CAD Protein of unknown function (DUF3311) B7492_03900 ENOG4105E1V na solute symporter B7492_03915 ENOG4108NHD germination protein B7492_03920 ENOG4105CE1 Ferrous iron transport protein b B7492_03925 ENOG4105CE1 Ferrous iron transport protein b B7492_03935 ENOG4105CVA phosphate B7492_03940 ENOG4105C8U phosphate abc transporter B7492_03945 ENOG4105E2Z phosphate ABC transporter (Permease B7492_04075 ENOG41080XQ Signal transduction protein with cbs domains B7492_04095 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B7492_04100 ENOG4105ETU transcriptional activator (TenA B7492_04110 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component B7492_04120 ENOG4108VEU Thiamine monophosphate synthase B7492_04125 ENOG41080HI glycine oxidase B7492_04140 ENOG4105D06 uba thif-type nad fad binding protein B7492_04145 ENOG4105DWF phosphomethylpyrimidine kinase B7492_04165 ENOG4105C19 ABC transporter B7492_04170 ENOG4105C3F Signal peptidase i B7492_04195 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) B7492_04200 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) B7492_04205 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) B7492_04220 ENOG4108INS Transcriptional regulator B7492_04265 ENOG4105YQ0 B7492_04390 ENOG4105CAR Terminase, large subunit B7492_04400 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B7492_04410 ENOG4105CYP glycoside hydrolase, family B7492_04475 ENOG4105XSJ toxin secretion phage lysis holin B7492_04480 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B7492_04510 ENOG4105C7N Xanthine uracil vitamin C permease B7492_04525 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein B7492_04540 ENOG4105K63 Thioredoxin B7492_04560 ENOG4108B31 Spore germination protein B7492_04580 ENOG4107Y03 Nitroreductase B7492_04585 ENOG4105ED1 spovr family B7492_04605 ENOG4105XTG Pfam:DUF156 B7492_04610 ENOG4105VFE sira family B7492_04615 ENOG4107TPS domain protein B7492_04620 ENOG4105VFE sira family B7492_04625 ENOG4105VFE sira family B7492_04630 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase B7492_04635 ENOG41087NI Sulfite exporter TauE/SafE B7492_04645 ENOG4108KGH TRANSCRIPTIONal B7492_04675 ENOG4105EMD TRANSCRIPTIONal B7492_04680 ENOG4105VCP PTS System B7492_04685 ENOG4105VZJ PTS System B7492_04705 ENOG41069ER domain protein B7492_04710 ENOG4107RBB ABC transporter, permease B7492_04715 ENOG4105C19 ABC transporter B7492_04735 ENOG4105WEF catalase B7492_04760 ENOG4107T5V SNARE associated Golgi B7492_04790 ENOG4105CUB amino acid B7492_04795 ENOG4107RWR Sodium hydrogen exchanger B7492_04805 ENOG4106KNT transcriptional regulator B7492_04810 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate B7492_04845 ENOG4108PCN EamA-like transporter family B7492_04850 ENOG4108YXU transcriptional regulator AsnC family B7492_04860 ENOG4108IXY short-chain dehydrogenase reductase B7492_04870 ENOG4105KPY Small multidrug resistance protein B7492_04875 ENOG4105KPY Small multidrug resistance protein B7492_04915 ENOG4105D5Q Arginine ornithine antiporter B7492_04920 ENOG4105C26 Dehydrogenase B7492_04940 ENOG4105BZ1 (ABC) transporter B7492_04945 ENOG4105BZ1 (ABC) transporter B7492_04955 ENOG4105DRP amino acid AbC transporter B7492_04960 ENOG4105CDA abc transporter atp-binding protein B7492_04975 ENOG410839P B7492_04985 ENOG4108UH6 UPF0754 membrane protein B7492_04990 ENOG4105WZB UPF0342 protein B7492_05010 ENOG4107FQX Alpha-acetolactate decarboxylase B7492_05015 ENOG4106WTF Glycosyl transferase, family 2 B7492_05020 ENOG4107R51 Glycosyl transferase, family 2 B7492_05025 ENOG4108VX5 3-methyladenine DNA glycosylase B7492_05040 ENOG4105D4P Coproporphyrinogen iii oxidase B7492_05050 ENOG4105CEY Amp-dependent synthetase and ligase B7492_05060 ENOG4105CHH sulfate transporter B7492_05110 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein B7492_05115 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein B7492_05130 ENOG4105CGU Enoyl-CoA hydratase B7492_05145 ENOG4105DER m42 family B7492_05175 ENOG4105D5U fad dependent oxidoreductase B7492_05205 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7492_05210 ENOG4105C3U ABC transporter B7492_05215 ENOG4108JQ7 (ABC) transporter B7492_05250 ENOG4108IBT Inherit from COG: transposase B7492_05315 ENOG4108IBT Inherit from COG: transposase B7492_05350 ENOG4105CSH Transporter B7492_05360 ENOG4108MRH transcriptional regulatory protein B7492_05370 ENOG4105M6F mutator MutT protein B7492_05400 ENOG4105CDU Replicative dna helicase B7492_05405 ENOG4107CUJ Protein of unknown function (DUF2690) B7492_05500 ENOG4105F27 Major Facilitator B7492_05505 ENOG4105WAB arsR family transcriptional regulator B7492_05530 ENOG4105CMT Dihydroxyacetone kinase B7492_05540 ENOG4105CMT Dihydroxyacetone kinase B7492_05555 ENOG4105FBW Monooxygenase B7492_05585 ENOG41082W1 Cupin 2, conserved barrel domain protein B7492_05600 ENOG4105F0F Oxalate decarboxylase B7492_05640 ENOG4105WN5 stage II sporulation protein B7492_05650 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7492_05660 ENOG4108MJI response regulator B7492_05665 ENOG4105BZU Histidine kinase B7492_05670 ENOG4105BZU Histidine kinase B7492_05705 ENOG4105ENE Histidine kinase B7492_05710 ENOG4108VB1 regulatoR B7492_05740 ENOG4107VRP DNA repair exonuclease B7492_05745 ENOG4106D4I domain protein B7492_05750 ENOG4105EQI Metal Dependent Phosphohydrolase B7492_05765 ENOG4105EKQ RNA-directed DNA polymerase B7492_05770 ENOG4107JM4 Tetratricopeptide repeat B7492_05785 ENOG4108MUZ hydrolase B7492_05795 ENOG41067QW Transcriptional regulator B7492_05800 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B7492_05810 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) B7492_05815 ENOG4105C6V Glycerol-3-phosphate dehydrogenase B7492_05830 ENOG4105EMN RNA polymerase sigma factor B7492_05845 ENOG4105EEM helicase B7492_05850 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B7492_05875 ENOG4105K59 histidine triad (HIT) protein B7492_05895 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B7492_05905 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) B7492_05920 ENOG410905X membrane-flanked domain protein B7492_05925 ENOG4105CKV Membrane B7492_05970 ENOG410905X membrane-flanked domain protein B7492_05975 ENOG4105CKV Membrane B7492_05980 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation B7492_05985 ENOG4105BZ4 penicillin-binding protein B7492_05990 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) B7492_06000 ENOG4105C1Q protoporphyrinogen oxidase B7492_06030 ENOG4105ECB domain protein B7492_06070 ENOG4106AXD B7492_06075 ENOG4108RQ5 Beta-lactamase domain-containing protein B7492_06080 ENOG4105DF9 Lipoate-protein, ligase B7492_06090 ENOG4105CEY Amp-dependent synthetase and ligase B7492_06105 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein B7492_06110 ENOG4108I5D sulfate abc transporter B7492_06115 ENOG4105ECW sulfate abc transporter B7492_06135 ENOG4105ST3 Transcriptional regulator B7492_06140 ENOG4105ENX hydrolase B7492_06145 ENOG4107RN3 metallophosphoesterase B7492_06150 ENOG4107TVP HD domain protein B7492_06160 ENOG4108AEY RNA polymerase sigma factor B7492_06170 ENOG41086D8 Transcriptional regulator B7492_06180 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7492_06200 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 B7492_06205 ENOG4105C8Q Methyl-accepting chemotaxis B7492_06230 ENOG4105ZU5 s-layer protein B7492_06235 ENOG4107QP3 malate synthase g B7492_06265 ENOG4105XVF Competence transcription factor B7492_06285 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination B7492_06290 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation B7492_06340 ENOG4105ERH Fumarylacetoacetate hydrolase B7492_06365 ENOG4105CAQ asparagine synthetase B7492_06380 ENOG4105CH6 catalase B7492_06385 ENOG4105BZU Histidine kinase B7492_06395 ENOG4108VPT UPF0234 protein B7492_06400 ENOG4105QNR S1 RNA binding domain protein B7492_06415 ENOG4108VJ1 Transcriptional regulator (CarD family B7492_06440 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B7492_06450 ENOG4107AYK membrAne B7492_06465 ENOG4108KP7 hydrolase B7492_06500 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B7492_06505 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) B7492_06530 ENOG4105C31 Tryptophanyl-tRNA synthetase B7492_06550 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B7492_06555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7492_06565 ENOG4108JQ7 (ABC) transporter B7492_06570 ENOG4105UQX Mate efflux family protein B7492_06595 ENOG4108ZCF integral membrane protein B7492_06605 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B7492_06615 ENOG4105DPN Oligoendopeptidase f B7492_06625 ENOG4108Z18 K06886 hemoglobin B7492_06630 ENOG4105MIX Adenylate cyclase B7492_06645 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) B7492_06650 ENOG4105EMS pseudouridine synthase B7492_06670 ENOG4105K64 Glycosyl transferase, family 2 B7492_06690 ENOG4107TVC Glycosyl transferase, family 2 B7492_06710 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) B7492_06715 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase B7492_06725 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase B7492_06810 ENOG4105CK7 Sodium proline symporter B7492_06820 ENOG4105CRQ synthase (Component I) B7492_06825 ENOG4105DDQ anthranilate synthase B7492_06830 ENOG4108I0Q anthranilate phosphoribosyltransferase B7492_06840 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase B7492_06845 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) B7492_06850 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) B7492_06935 ENOG4105C7S Dehydrogenase B7492_06940 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 B7492_06970 ENOG4108IUX (ABC) transporter B7492_06975 ENOG4105RHA ABC transporter, permease B7492_07050 ENOG4105VTR Integrase B7492_07070 ENOG4105DZ1 carboxypeptidase B7492_07075 ENOG4105VFR signal peptidase B7492_07110 ENOG4105C26 Dehydrogenase B7492_07120 ENOG4105F38 ABC transporter, permease B7492_07125 ENOG4105D38 putrescine abc transporter B7492_07130 ENOG4107RUE extracellular solute-binding protein family 1 B7492_07140 ENOG4105EYF MMPL domain protein B7492_07155 ENOG4108YBP pseudouridine synthase B7492_07165 ENOG4105K4I Scp-like extracellular B7492_07170 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B7492_07175 ENOG4105CQB FAD linked oxidase domain protein B7492_07190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_07195 ENOG4105BZU Histidine kinase B7492_07200 ENOG4105JXH GntR family transcriptional regulator B7492_07210 ENOG4107QR9 Iron-sulfur cluster binding protein B7492_07220 ENOG4106A3R peptidase B7492_07230 ENOG4108QTI )-transporter B7492_07235 ENOG4107TS3 membrane protein, TerC B7492_07240 ENOG4105CZN Potassium uptake protein B7492_07245 ENOG410681C small acid-soluble spore protein B7492_07250 ENOG4108Z7G MaoC domain protein dehydratase B7492_07270 ENOG4105CHR reductase B7492_07300 ENOG4105C4Y ABC transporter B7492_07305 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B7492_07310 ENOG4107RCV ABC transporter, permease B7492_07315 ENOG4108KAZ Involved in phosphonate degradation (By similarity) B7492_07320 ENOG4107QMX Aminotransferase B7492_07340 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) B7492_07350 ENOG4105PXI polysaccharide deacetylase B7492_07360 ENOG4105BZU Histidine kinase B7492_07365 ENOG41090MY MarR family Transcriptional regulator B7492_07375 ENOG4106DF1 B7492_07380 ENOG4105BZU Histidine kinase B7492_07385 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) B7492_07390 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase B7492_07395 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) B7492_07400 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) B7492_07415 ENOG4108R6G acetyltransferase B7492_07435 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) B7492_07440 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B7492_07445 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B7492_07450 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B7492_07455 ENOG4105CUB amino acid B7492_07465 ENOG4108JUB Transcriptional regulator B7492_07470 ENOG4105C26 Dehydrogenase B7492_07475 ENOG4105C8Y Acetylornithine aminotransferase B7492_07480 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family B7492_07485 ENOG4105CZV ABC transporter B7492_07495 ENOG4105CJ1 ABC, transporter B7492_07535 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B7492_07540 ENOG4105EA8 2-Nitropropane dioxygenase B7492_07545 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B7492_07550 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) B7492_07555 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein B7492_07575 ENOG4105NQC Flavodoxin B7492_07605 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B7492_07640 ENOG4105CZN Potassium uptake protein B7492_07650 ENOG4105KBJ sporulation protein ytfj B7492_07670 ENOG4105CM2 brancheD-chain amino acid aminotransferase B7492_07675 ENOG4105C7K acetolactate synthase B7492_07680 ENOG4108ZP8 Acetolactate synthase small subunit B7492_07685 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B7492_07690 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) B7492_07700 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) B7492_07710 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) B7492_07715 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) B7492_07725 ENOG4105ECC imidazole-glycerol-phosphate dehydratase B7492_07730 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) B7492_07735 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase B7492_07740 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) B7492_07750 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase B7492_07755 ENOG4107RVV histidinol phosphate phosphatase, hisj family B7492_07770 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B7492_07775 ENOG4105E0M Sulfatase B7492_07780 ENOG4105VTR Integrase B7492_07825 ENOG4106CVF DNA replication protein B7492_07835 ENOG4105KRN Transcriptional regulator, abrb family B7492_07910 ENOG4105XSJ toxin secretion phage lysis holin B7492_07925 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) B7492_07935 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) B7492_07940 ENOG4107RIQ Sulfate adenylate transferase B7492_07945 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) B7492_07950 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) B7492_07960 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B7492_07965 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B7492_07970 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B7492_07975 ENOG4105C8J )-transporter B7492_07995 ENOG4105DFD Na H antiporter B7492_08020 ENOG4105ENE Histidine kinase B7492_08025 ENOG4105WH1 Two component transcriptional regulator luxr family B7492_08045 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) B7492_08090 ENOG4105CJ3 phosphate transporter B7492_08095 ENOG4107GRR phosphate transport regulator B7492_08110 ENOG4105BZU Histidine kinase B7492_08115 ENOG4105I3N Conserved Protein B7492_08135 ENOG4105BZU Histidine kinase B7492_08165 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B7492_08170 ENOG4105DZ1 carboxypeptidase B7492_08175 ENOG4108JIC nucleoside recognition domain protein B7492_08185 ENOG4105FE9 pseudouridine synthase B7492_08195 ENOG4107TWT Cytochrome c biogenesis protein B7492_08200 ENOG4105CRE cytochrome C B7492_08205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_08210 ENOG4105BZU Histidine kinase B7492_08215 ENOG4108WBT adenosyltransferase B7492_08220 ENOG41063SB peptidase B7492_08230 ENOG4108SAX Membrane B7492_08245 ENOG4105T7X B7492_08250 ENOG4105C9U ATP-dependent DNA helicase RecQ B7492_08255 ENOG4105I7S Abortive infection protein B7492_08265 ENOG4107RGJ metallophosphoesterase B7492_08270 ENOG4107X2D transcriptional regulator, merr family B7492_08275 ENOG4108S6Z Negative regulator of genetic competence B7492_08300 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase B7492_08305 ENOG4107RB3 L-asparaginase B7492_08310 ENOG4105CAT Cytidine monophosphate kinase B7492_08320 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) B7492_08345 ENOG4105S2F B7492_08350 ENOG41065D1 B7492_08355 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) B7492_08360 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase B7492_08380 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) B7492_08400 ENOG4105XXQ heptaprenyl diphosphate synthase component I B7492_08405 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B7492_08410 ENOG4105EAH synthase B7492_08415 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) B7492_08420 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase B7492_08425 ENOG4105D49 3-dehydroquinate synthase B7492_08435 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase B7492_08440 ENOG41068YB TPR repeat-containing protein B7492_08455 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) B7492_08460 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) B7492_08465 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit B7492_08500 ENOG4108JYZ YitT family B7492_08505 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase B7492_08510 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) B7492_08515 ENOG4108Z5K methylglyoxal synthase B7492_08520 ENOG4105FJR Lmbe family B7492_08525 ENOG4105CPK Glycosyl transferase (Group 1 B7492_08530 ENOG4105DJ0 Poly(A) Polymerase B7492_08540 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) B7492_08545 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) B7492_08555 ENOG4105DVT helicase B7492_08560 ENOG4105YAC B7492_08580 ENOG4105CSM endonuclease III B7492_08590 ENOG4105BZ4 penicillin-binding protein B7492_08630 ENOG4108UKS UPF0398 protein B7492_08635 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) B7492_08645 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) B7492_08655 ENOG4105DVT helicase B7492_08660 ENOG4105CTD carboxy-peptidase B7492_08675 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B7492_08680 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) B7492_08685 ENOG4105C2W permease B7492_08690 ENOG4105DHF Membrane B7492_08695 ENOG410890F Dynamin family B7492_08705 ENOG4108W0I acetyltransferase B7492_08715 ENOG4105KHC sulfurtransferase B7492_08770 ENOG4108SZE gCN5-related N-acetyltransferase B7492_08790 ENOG41081VK Ribonuclease B7492_08860 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7492_08870 ENOG4107RWR Sodium hydrogen exchanger B7492_08875 ENOG4108Z5V transcriptional regulator, merr family B7492_08885 ENOG4105H67 Protein of unknown function (DUF421) B7492_08890 ENOG41080C8 DUF218 domain B7492_08950 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) B7492_08960 ENOG4107R0U MotA TolQ exbB proton channel B7492_08965 ENOG4105ER2 Ompa motb domain protein B7492_08970 ENOG4107YTP response regulator receiver protein B7492_08975 ENOG4105CBS Chea signal transduction histidine kinase B7492_08980 ENOG4105DD5 Flagellar motor switch protein B7492_08995 ENOG4105BZU Histidine kinase B7492_09015 ENOG4105E1Q flagellar hook-associated protein B7492_09020 ENOG4105DTJ flagellar hook-associated protein B7492_09025 ENOG4105DTS flagellar hook-associated B7492_09045 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) B7492_09050 ENOG4108ZC9 flagellar basal-body rod protein flgc B7492_09055 ENOG41075Z6 flagellar hook-basal body complex protein fliE B7492_09060 ENOG4107U2N Flagellar M-ring protein B7492_09065 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B7492_09095 ENOG4105BZE flagellar hook protein, FlgE B7492_09110 ENOG4107R88 Chemotaxis protein (CheV) B7492_09120 ENOG4105E1K spore germination protein B7492_09135 ENOG4107TS3 membrane protein, TerC B7492_09145 ENOG4108JB9 formate dehydrogenase B7492_09155 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) B7492_09160 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B7492_09170 ENOG4105TMB Formate nitrite transporter B7492_09175 ENOG4105D06 uba thif-type nad fad binding protein B7492_09180 ENOG4105CVM Molybdenum cofactor synthesis domain protein B7492_09185 ENOG4108ZAF Molybdopterin B7492_09190 ENOG41067WU Molybdopterin converting factor (Subunit 1) B7492_09195 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B7492_09200 ENOG4105D1F ATP-binding protein B7492_09205 ENOG4105I03 Flagellin B7492_09210 ENOG4105I03 Flagellin B7492_09215 ENOG4105E4C Lytic transglycosylase catalytic B7492_09225 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B7492_09230 ENOG4105DD5 Flagellar motor switch protein B7492_09240 ENOG4105CN7 Flagellar biosynthetic protein FliP B7492_09245 ENOG4105VS8 Flagellar biosynthetic protein fliq B7492_09255 ENOG4105D00 flagellar biosynthetic protein flhB B7492_09260 ENOG4105D7B Flagellar biosynthesis protein flha B7492_09265 ENOG4105FZW flagellar biosynthesis regulator FlhF B7492_09270 ENOG4108KPB Flagellar basal-body rod protein FlgF B7492_09315 ENOG4105KAC Antibiotic biosynthesis monooxygenase B7492_09340 ENOG4105DUM transcriptional regulator, lysR family B7492_09345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B7492_09355 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component B7492_09405 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) B7492_09425 ENOG4105CAQ asparagine synthetase B7492_09445 ENOG4105PGM cation diffusion facilitator family transporter B7492_09455 ENOG4105DRR Transcriptional regulator, GntR family B7492_09460 ENOG4108UZ3 Transporter B7492_09480 ENOG4105DFD Na H antiporter B7492_09485 ENOG4105C9Q fumarate hydratase class II B7492_09505 ENOG4107QJQ Mate efflux family protein B7492_09510 ENOG4105EC3 peptidase S51, dipeptidase E B7492_09530 ENOG4107QIV Cytochrome c biogenesis protein B7492_09535 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B7492_09550 ENOG4105BZC d-serine deaminase B7492_09555 ENOG4106BRA Membrane B7492_09595 ENOG4105CJ1 ABC, transporter B7492_09615 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) B7492_09625 ENOG4108IJ0 Aspartate ammonia-lyase B7492_09630 ENOG4105C6K Malic enzyme B7492_09660 ENOG4105CU9 asparagine synthetase A B7492_09695 ENOG4105FVX B7492_09700 ENOG4105E09 nadh pyrophosphatase B7492_09735 ENOG4105CSR polyphosphate kinase 2 B7492_09740 ENOG4105U3E Transcriptional regulator B7492_09750 ENOG4105DXI Major Facilitator superfamily B7492_09765 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B7492_09770 ENOG4105EU0 Major facilitator Superfamily B7492_09775 ENOG4105C6T cysteine synthase B7492_09795 ENOG4105C8J )-transporter B7492_09805 ENOG4105X5K response regulator receiver protein B7492_09810 ENOG4105H67 Protein of unknown function (DUF421) B7492_09825 ENOG4105KVH Transcriptional regulator B7492_09830 ENOG4108UW5 maltose o-acetyltransferase B7492_09835 ENOG4105KVH Transcriptional regulator B7492_09840 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B7492_09855 ENOG4108IQI permease B7492_09860 ENOG4105D3R alkyl hydroperoxide reductase B7492_09865 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) B7492_09870 ENOG4105CHR reductase B7492_09875 ENOG4105CM2 brancheD-chain amino acid aminotransferase B7492_09880 ENOG4105C7K acetolactate synthase B7492_09890 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B7492_09900 ENOG4105C7B Threonine dehydratase B7492_09925 ENOG4105C6X Major Facilitator B7492_09930 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b B7492_09980 ENOG41068WN B7492_10000 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) B7492_10005 ENOG4105C72 UPF0176 protein B7492_10015 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) B7492_10020 ENOG4105C0X amino acid B7492_10055 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) B7492_10060 ENOG4105KNA -acetyltransferase B7492_10070 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid B7492_10075 ENOG4107RHR regulatoR B7492_10085 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) B7492_10090 ENOG4105D9N nucleoside B7492_10095 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) B7492_10125 ENOG410811B TRANSCRIPTIONal B7492_10145 ENOG4105DQ6 Transposase B7492_10155 ENOG4107R16 Multicopper oxidase B7492_10205 ENOG4108T5E Copper resistance protein B7492_10210 ENOG4105KTB nuclear export factor GLE1 B7492_10220 ENOG4107RT3 EamA-like transporter family B7492_10225 ENOG4105GZI Transcriptional regulator B7492_10230 ENOG4108Z40 Transcriptional regulator B7492_10235 ENOG4107ZXU DSBA oxidoreductase B7492_10240 ENOG4108TVJ Nitroreductase B7492_10250 ENOG4106F5Q Membrane B7492_10260 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B7492_10270 ENOG4105CKI cobalamin synthesis protein B7492_10280 ENOG4105C0Z ABC transporter B7492_10285 ENOG4108IV0 ABC, transporter B7492_10290 ENOG4105C32 Amino acid ABC transporter (Permease) B7492_10300 ENOG4105SKE transcriptional Regulator LysR family B7492_10310 ENOG4105MDS 4-oxalocrotonate tautomerase B7492_10335 ENOG4105C4M (Ubiquinol oxidase) subunit I B7492_10340 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B7492_10345 ENOG4108JJ9 ABC, transporter B7492_10350 ENOG4108JJ8 (ABC) transporter B7492_10400 ENOG4105BZ1 (ABC) transporter B7492_10405 ENOG4105EFI regulatoR B7492_10410 ENOG4105BZU Histidine kinase B7492_10420 ENOG4108VQJ O-methyltransferase B7492_10425 ENOG41075D4 Aminoglycoside 6-adenylyltransferase B7492_10430 ENOG4108ZJ4 polysaccharide deacetylase B7492_10450 ENOG4105D6E homoserine dehydrogenase B7492_10460 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) B7492_10475 ENOG4108KGH TRANSCRIPTIONal B7492_10480 ENOG4107VMI polysaccharide deacetylase B7492_10490 ENOG4105KT7 mgtC SapB transporter B7492_10495 ENOG4105VRR gCN5-related N-acetyltransferase B7492_10505 ENOG4105DUU IucA IucC family protein B7492_10510 ENOG4105CEY Amp-dependent synthetase and ligase B7492_10525 ENOG4108WBH protein TIM barrel B7492_10530 ENOG4105YWU small acid-soluble spore protein B7492_10540 ENOG4108ZUB Lysine exporter protein (Lyse ygga) B7492_10545 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7492_10595 ENOG4105KRN Transcriptional regulator, abrb family B7492_10605 ENOG4105YVS arsR family transcriptional regulator B7492_10610 ENOG4107SET aldo keto reductase B7492_10655 ENOG4108K88 Membrane B7492_10660 ENOG4108WPJ Ferritin-like domain B7492_10675 ENOG4105DEN Luciferase family B7492_10690 ENOG4105VMI -acetyltransferase B7492_10700 ENOG4105D74 hydrolase B7492_10705 ENOG4105D29 Helix-turn-helix type 11 domain protein B7492_10720 ENOG4107QM2 Aldo Keto reductase B7492_10725 ENOG4105CKI cobalamin synthesis protein B7492_10735 ENOG4105DSE periplasmic solute binding protein B7492_10750 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B7492_10755 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B7492_10780 ENOG4107TB6 phosphoglycerate mutase B7492_10800 ENOG4107T5V SNARE associated Golgi B7492_10815 ENOG4108PJD permease B7492_10825 ENOG4108S4H thioesterase Superfamily protein B7492_10860 ENOG4105SXS Protein of unknown function (DUF456) B7492_10865 ENOG4105C37 (CBS) domain B7492_10885 ENOG4108Z7R Chaperone CsaA B7492_10905 ENOG4108ZRV stage ii sporulation protein p B7492_10920 ENOG4108VXD carboxy-peptidase B7492_10930 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B7492_10950 ENOG4108ZRV stage ii sporulation protein p B7492_11005 ENOG4105YQ0 B7492_11130 ENOG4105CAR Terminase, large subunit B7492_11260 ENOG41082F9 transcriptional regulator B7492_11265 ENOG4105D94 Major Facilitator Superfamily B7492_11275 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B7492_11295 ENOG41087PP glycosyltransferase MGT family B7492_11315 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7492_11340 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B7492_11370 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) B7492_11375 ENOG4108MGT Required for secretion of EsxA and EsxB B7492_11465 ENOG4105KBJ sporulation protein ytfj B7492_11490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B7492_11520 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein B7492_11525 ENOG4105EMN RNA polymerase sigma factor B7492_11550 ENOG4105CNW domain protein B7492_11560 ENOG4108V06 Glutathione peroxidase B7492_11575 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B7492_11585 ENOG4108IUE nitrate reductase beta subunit B7492_11590 ENOG4105R3A Nitrate reductase B7492_11600 ENOG4107V6Q Cyclic nucleotide-binding domain B7492_11605 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B7492_11610 ENOG4105D06 uba thif-type nad fad binding protein B7492_11615 ENOG4105CVM Molybdenum cofactor synthesis domain protein B7492_11620 ENOG4108ZAF Molybdopterin B7492_11640 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B7492_11645 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B7492_11650 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B7492_11655 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit B7492_11660 ENOG4108IFG nitrite reductase, (NAD(P)H) B7492_11685 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) B7492_11715 ENOG4105MCT stage V sporulation protein S B7492_11720 ENOG4107T65 Integrase B7492_11725 ENOG410635T phage-like element pbsx protein B7492_11735 ENOG4105M6F mutator MutT protein B7492_11765 ENOG4108IMY Transcriptional regulator B7492_11880 ENOG4105C5H ABC transporter B7492_11895 ENOG4108UUM single-stranded DNA-binding protein B7492_11935 ENOG4107YX5 Pfam:DUF548 B7492_11940 ENOG4105C75 arginyL-tRNA synthetase B7492_12000 ENOG4105C5S asparaginyl-tRNA synthetase B7492_12005 ENOG4105C8J )-transporter B7492_12025 ENOG4107XGZ Hydrolase B7492_12030 ENOG4105CY2 Citrate transporter B7492_12050 ENOG4105KD7 acetyltransferase B7492_12055 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase B7492_12075 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 B7492_12095 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) B7492_12110 ENOG4107RVG penicillin-binding protein B7492_12120 ENOG4105E9Q Acyl-transferase B7492_12125 ENOG4108UT2 hemolysin iii B7492_12130 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) B7492_12135 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B7492_12150 ENOG4105E8R UPF0173 metal-dependent hydrolase B7492_12155 ENOG4108KF3 Electron transport protein SCO1 SenC B7492_12160 ENOG4107Y70 Heat shock protein B7492_12165 ENOG4105CAQ asparagine synthetase B7492_12180 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B7492_12185 ENOG4108MES Periplasmic binding protein B7492_12190 ENOG4105F0I Aminotransferase B7492_12205 ENOG4105EKQ RNA-directed DNA polymerase B7492_12230 ENOG4105D8X mechanosensitive ion channel B7492_12235 ENOG4105BZU Histidine kinase B7492_12240 ENOG4105WH1 Two component transcriptional regulator luxr family B7492_12245 ENOG4106KNT transcriptional regulator B7492_12265 ENOG4105CMG Carbohydrate kinase B7492_12270 ENOG4105C6Z Gluconate B7492_12295 ENOG4108IJ8 ABC transporter B7492_12300 ENOG4105E90 ABC transporter B7492_12335 ENOG4105C37 (CBS) domain B7492_12360 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7492_12375 ENOG4107S4Y M20 DapE family protein YgeY B7492_12380 ENOG4108TSC N-acetyltransferase B7492_12385 ENOG4108JUB Transcriptional regulator B7492_12390 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein B7492_12435 ENOG410841Q phosphoesterase PA-phosphatase related protein B7492_12445 ENOG4105SZ6 Thioredoxin B7492_12510 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B7492_12540 ENOG4105CHR reductase B7492_12560 ENOG4105BZ4 penicillin-binding protein B7492_12585 ENOG4105DXD 2-methylcitrate dehydratase B7492_12590 ENOG4105CR4 methylisocitrate lyase B7492_12595 ENOG4105C1G acyl-Coa dehydrogenase B7492_12600 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B7492_12610 ENOG4105N14 lysine exporter protein LysE YggA B7492_12615 ENOG4105E39 Enoyl-CoA hydratase B7492_12630 ENOG4107RFY SbcCD D subunit B7492_12645 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B7492_12660 ENOG4105FCD Major Facilitator B7492_12665 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase B7492_12670 ENOG4105E4F Isochorismate synthase B7492_12675 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase B7492_12680 ENOG4105WQI isochorismatase B7492_12685 ENOG4105CEY Amp-dependent synthetase and ligase B7492_12690 ENOG4105WQT MbtH domain protein B7492_12695 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7492_12710 ENOG4105K70 DNA-binding protein B7492_12725 ENOG4105BZG amino acid carrier protein B7492_12755 ENOG4105FE9 pseudouridine synthase B7492_12760 ENOG4105C22 threonyL-tRNA synthetase B7492_12765 ENOG4105VMP Transcriptional regulator B7492_12775 ENOG4105C19 ABC transporter B7492_12785 ENOG4107SKW Inherit from COG: Alpha beta hydrolase B7492_12825 ENOG4105C37 (CBS) domain B7492_12845 ENOG41081I9 integral membrane protein B7492_12855 ENOG4108Y4K DNA-binding transcriptional activator B7492_12885 ENOG41067SE Tetr family transcriptional regulator B7492_12890 ENOG4105EYF MMPL domain protein B7492_12900 ENOG4108Q8B Spore germination protein B7492_12905 ENOG4108NHD germination protein B7492_12920 ENOG4105WCN acetyltransferase B7492_12965 ENOG4105C1Q protoporphyrinogen oxidase B7492_12975 ENOG41068WN B7492_13005 ENOG4107V2S Transcriptional regulator B7492_13010 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B7492_13030 ENOG4105DND Transcriptional regulator B7492_13035 ENOG4108JPW Aminotransferase B7492_13040 ENOG4108RPX mosc domain containing protein B7492_13055 ENOG4105BZ1 (ABC) transporter B7492_13060 ENOG4105BZ1 (ABC) transporter B7492_13090 ENOG4105F6S Spore photoproduct lyase B7492_13130 ENOG4108JCI Transcriptional regulator B7492_13160 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B7492_13170 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B B7492_13175 ENOG4108KPJ rna polymerase sigma factor B7492_13195 ENOG4105F32 YngK protein B7492_13215 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) B7492_13220 ENOG4105RD7 BadF BadG BcrA BcrD B7492_13230 ENOG4107STF Involved in phosphonate degradation (By similarity) B7492_13280 ENOG4105C1J atp-dependent rna helicase B7492_13285 ENOG41088CC tellurite resistance protein tehB B7492_13300 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) B7492_13325 ENOG4105CIN aminoacyl-histidine dipeptidase B7492_13335 ENOG4108NGU Transcriptional regulator B7492_13340 ENOG4108UMN azlc family B7492_13360 ENOG4105C19 ABC transporter B7492_13380 ENOG4105BZU Histidine kinase B7492_13435 ENOG4105W8Z 4'-phosphopantetheinyl transferase B7492_13490 ENOG4107RVG penicillin-binding protein B7492_13495 ENOG4105EMN RNA polymerase sigma factor B7492_13505 ENOG4107RF6 penicillin-binding protein B7492_13510 ENOG4107RF6 penicillin-binding protein B7492_13565 ENOG4105C5E polysaccharide biosynthesis protein B7492_13570 ENOG4105C1B dTDP-glucose 4-6-dehydratase B7492_13575 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B7492_13580 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) B7492_13630 ENOG4105CEP NADH dehydrogenase B7492_13635 ENOG4107TPS domain protein B7492_13650 ENOG4105E1K spore germination protein B7492_13680 ENOG4108M1A Chitin-binding protein B7492_13685 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C B7492_13695 ENOG4107RGJ metallophosphoesterase B7492_13705 ENOG4105CJ1 ABC, transporter B7492_13715 ENOG4107Z3H Transcriptional regulator, TetR family B7492_13725 ENOG4105C1G acyl-Coa dehydrogenase B7492_13730 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B7492_13735 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit B7492_13740 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase B7492_13745 ENOG4105E39 Enoyl-CoA hydratase B7492_13750 ENOG4107QX3 carboxylase B7492_13755 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B7492_13820 ENOG4105T9C HD domain B7492_13830 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B7492_13850 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B7492_13875 ENOG4105CHR reductase B7492_13880 ENOG4105KVH Transcriptional regulator B7492_13920 ENOG4105SX7 Transporter B7492_13935 ENOG4105CHR reductase B7492_13960 ENOG410900G Protein of unknown function (DUF421) B7492_13975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7492_13980 ENOG4105FDR Membrane B7492_13985 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) B7492_13990 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B7492_14000 ENOG4105CGH 5'-nucleotidase B7492_14015 ENOG4108IUM Glycogen debranching enzyme B7492_14050 ENOG4107WD8 ABC transporter, permease B7492_14070 ENOG4105BZU Histidine kinase B7492_14075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_14080 ENOG4105U0R haloacid dehalogenase-like hydrolase B7492_14105 ENOG4107VFR oxidoreductase B7492_14110 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B7492_14120 ENOG4105BZ1 (ABC) transporter B7492_14125 ENOG4107RA9 decarboxylase B7492_14145 ENOG4105PKS Excinuclease abc c subunit domain protein B7492_14180 ENOG4105KWG Pfam:DUF1696 B7492_14185 ENOG4108NRW Phospholipase, patatin family B7492_14210 ENOG4108XI2 Domain of unknown function (DUF1963) B7492_14235 ENOG4108Z4K mutator MutT protein B7492_14240 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B7492_14245 ENOG4105E09 nadh pyrophosphatase B7492_14250 ENOG4105FCD Major Facilitator B7492_14285 ENOG4107Y9U Membrane B7492_14300 ENOG4107VXM glycerophosphoryl diester phosphodiesterase B7492_14315 ENOG4105KVH Transcriptional regulator B7492_14335 ENOG4105BZ1 (ABC) transporter B7492_14370 ENOG4105CJN penicillin-binding protein B7492_14375 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase B7492_14380 ENOG4105CB2 alcohol dehydrogenase B7492_14400 ENOG4108HGU Histidine kinase B7492_14415 ENOG4108JJB ABC transporter B7492_14420 ENOG4108V7D UPF0397 protein B7492_14440 ENOG4107RF6 penicillin-binding protein B7492_14445 ENOG4105BZU Histidine kinase B7492_14450 ENOG410667J hydrolase B7492_14555 ENOG4105ETU transcriptional activator (TenA B7492_14570 ENOG4105D6E homoserine dehydrogenase B7492_14610 ENOG4105CPC Aldo Keto reductase B7492_14615 ENOG4106NZI LysR family Transcriptional regulator B7492_14640 ENOG4105DK7 lysyl-tRNA synthetase B7492_14650 ENOG4105CIS alcohol dehydrogenase B7492_14675 ENOG4105D7V transposase B7492_14705 ENOG4105MSI germination protein ypeb B7492_14730 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) B7492_14735 ENOG4106IPI cyclase, family B7492_14740 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) B7492_14745 ENOG4107Z3H Transcriptional regulator, TetR family B7492_14760 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family B7492_14775 ENOG4105E98 transcriptional regulator DeoR family B7492_14800 ENOG4107QKR Dehydrogenase B7492_14810 ENOG4107RUY (E1 component), alpha subunit B7492_14820 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) B7492_14830 ENOG4105E1F short-chain dehydrogenase reductase B7492_14835 ENOG4105RHY Pfam:UPF0157 B7492_14865 ENOG4107SQ8 Glycine betaine B7492_14870 ENOG4108IJ7 Glycine betaine B7492_14895 ENOG4105E66 phosphoriboisomerase A B7492_14900 ENOG41082BV acetyltransferase B7492_14905 ENOG4108M1A Chitin-binding protein B7492_14915 ENOG41087PP glycosyltransferase MGT family B7492_14935 ENOG4105MSB protein, conserved in bacteria B7492_14960 ENOG4108Z7F N-acetyltransferase B7492_14980 ENOG4105EEM helicase B7492_14995 ENOG4105C9U ATP-dependent DNA helicase RecQ B7492_15025 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase B7492_15030 ENOG4108M1A Chitin-binding protein B7492_15050 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) B7492_15060 ENOG4105BZG amino acid carrier protein B7492_15065 ENOG4105C26 Dehydrogenase B7492_15070 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B7492_15075 ENOG4105CTU Proline racemase B7492_15080 ENOG4105CTU Proline racemase B7492_15085 ENOG41080HI glycine oxidase B7492_15095 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein B7492_15125 ENOG4107T5V SNARE associated Golgi B7492_15140 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B7492_15155 ENOG4105DTQ mandelate racemase muconate lactonizing B7492_15175 ENOG4105CPC Aldo Keto reductase B7492_15220 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) B7492_15230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_15280 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 B7492_15285 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B7492_15290 ENOG4105DPN Oligoendopeptidase f B7492_15305 ENOG4105EPR degv family B7492_15335 ENOG4105CHJ isochorismatase hydrolase B7492_15370 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) B7492_15375 ENOG4106K7D Major facilitator family transporter B7492_15405 ENOG4107BMA Transglycosylase associated protein B7492_15420 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B7492_15455 ENOG4105CHM Aminotransferase B7492_15485 ENOG4105DVE abc transporter atp-binding protein B7492_15490 ENOG4105FDP GntR family transcriptional regulator B7492_15535 ENOG4105C02 permease B7492_15545 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) B7492_15550 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component B7492_15555 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein B7492_15560 ENOG4105D7T ABC transporter B7492_15590 ENOG4108AQF aminoglycoside N(3)-acetyltransferase B7492_15610 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase B7492_15615 ENOG41090R9 glycosyltransferase B7492_15620 ENOG4105C1B dTDP-glucose 4-6-dehydratase B7492_15625 ENOG4105FAW cDP-glucose 4,6-dehydratase B7492_15675 ENOG4105C6T cysteine synthase B7492_15680 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase B7492_15710 ENOG4105DQ6 Transposase B7492_15720 ENOG4108QY0 Membrane B7492_15735 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase B7492_15785 ENOG4107VMI polysaccharide deacetylase B7492_15800 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7492_15815 ENOG4105C5H ABC transporter B7492_15820 ENOG4105EYF MMPL domain protein B7492_15825 ENOG41082JN Transcriptional regulator B7492_15855 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase B7492_15860 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase B7492_15905 ENOG41069ER domain protein B7492_15915 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase B7492_15925 ENOG4108YYH Nadph-dependent fmn reductase B7492_15955 ENOG4105DWT malate dehydrogenase (quinone) B7492_15960 ENOG4105D4B ABC, transporter B7492_15970 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane B7492_15975 ENOG4105C2J ABC transporter B7492_15980 ENOG4105DKT Transcriptional regulator B7492_15985 ENOG4107RYS Autoinducer-2 (AI-2) kinase B7492_15995 ENOG41061GT Aldolase B7492_16000 ENOG4108I0C methyltransferase B7492_16015 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase B7492_16020 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) B7492_16050 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) B7492_16055 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) B7492_16065 ENOG4105II7 pyrroline-5-carboxylate reductase B7492_16070 ENOG4105ECK Fatty Acid Desaturase B7492_16085 ENOG4105VMP Transcriptional regulator B7492_16130 ENOG41068WN B7492_16160 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B7492_16180 ENOG4105C8Y Acetylornithine aminotransferase B7492_16215 ENOG4108TVJ Nitroreductase B7492_16220 ENOG4105FS7 Transcriptional regulator B7492_16240 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B7492_16270 ENOG4108XET gCN5-related N-acetyltransferase B7492_16295 ENOG4107XJU UPF0178 protein B7492_16325 ENOG4105RHY Pfam:UPF0157 B7492_16350 ENOG410635A Membrane B7492_16360 ENOG4108IQI permease B7492_16370 ENOG4105F1N DNA alkylation repair B7492_16405 ENOG4107RF6 penicillin-binding protein B7492_16410 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) B7492_16415 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) B7492_16430 ENOG4105E7W lamb ycsf family protein B7492_16440 ENOG4105P4J Allophanate hydrolase, subunit 1 B7492_16445 ENOG4107258 Transcriptional regulator B7492_16455 ENOG4106N3A copper homeostasis protein cutc B7492_16465 ENOG4108ZHR arsR family transcriptional regulator B7492_16475 ENOG4105FDT acyl-CoA dehydrogenase B7492_16500 ENOG41082BM Transcriptional regulator, arsr family B7492_16525 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B7492_16625 ENOG4105E2A Dehydrogenase B7492_16645 ENOG4105WEF catalase B7492_16650 ENOG4105CN5 Metallo-Beta-Lactamase B7492_16660 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B7492_16690 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein B7492_16705 ENOG4107VMI polysaccharide deacetylase B7492_16710 ENOG4105BZU Histidine kinase B7492_16715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_16720 ENOG4108U7W acetyltransferase B7492_16725 ENOG4105DSE periplasmic solute binding protein B7492_16730 ENOG4105CC5 ABC transporter B7492_16735 ENOG4105DIK (ABC) transporter B7492_16750 ENOG4108KF3 Electron transport protein SCO1 SenC B7492_16755 ENOG4107ZQN disulfide bond B7492_16785 ENOG4105D6J arsenicaL-resistance protein B7492_16790 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase B7492_16795 ENOG41085FC arsR family transcriptional regulator B7492_16805 ENOG4105CHR reductase B7492_16810 ENOG4108YXU transcriptional regulator AsnC family B7492_16855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_16860 ENOG41062D9 Histidine kinase B7492_16890 ENOG4105EKQ RNA-directed DNA polymerase B7492_16915 ENOG4105K6H D-cysteine desulfhydrase B7492_16940 ENOG4105CK5 oxidoreductase B7492_16945 ENOG4105CK5 oxidoreductase B7492_16970 ENOG4105W1Y Transcriptional regulator B7492_16990 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) B7492_16995 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) B7492_17020 ENOG4105DQ6 Transposase B7492_17025 ENOG4105BZU Histidine kinase B7492_17035 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) B7492_17050 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B7492_17075 ENOG4108JQ1 Dehydrogenase B7492_17080 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) B7492_17110 ENOG4108IG5 Transcriptional regulator B7492_17220 ENOG4108ISG Major Facilitator B7492_17235 ENOG4107MII Sugar-specific transcriptional regulator TrmB B7492_17240 ENOG4105CZM Major Facilitator B7492_17260 ENOG41082BM Transcriptional regulator, arsr family B7492_17280 ENOG4108VJ1 Transcriptional regulator (CarD family B7492_17295 ENOG4108594 Permease of the drug metabolite transporter B7492_17300 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7492_17380 ENOG4107258 Transcriptional regulator B7492_17400 ENOG4105CRW Short chain fatty acid transporter B7492_17410 ENOG4105DYS nad(p)h dehydrogenase (quinone) B7492_17475 ENOG4108K8S endonuclease I B7492_17480 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B7492_17485 ENOG4108Z66 YbaK ebsC protein B7492_17490 ENOG4105CUT histidyl-tRNA synthetase B7492_17510 ENOG4105G6Z alkaline phosphatase B7492_17520 ENOG4108RCM Nitroreductase B7492_17525 ENOG4105KVH Transcriptional regulator B7492_17540 ENOG4108PSK reductase B7492_17610 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase B7492_17615 ENOG4105DKQ ROK family B7492_17620 ENOG4106UW1 Major Facilitator superfamily B7492_17625 ENOG4108UW5 maltose o-acetyltransferase B7492_17630 ENOG4105C31 Tryptophanyl-tRNA synthetase B7492_17645 ENOG4107BMA Transglycosylase associated protein B7492_17675 ENOG4105EV4 Multidrug resistance protein mdtH B7492_17700 ENOG4105C37 (CBS) domain B7492_17715 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase B7492_17720 ENOG4105FAW cDP-glucose 4,6-dehydratase B7492_17750 ENOG4105DDN Pentapeptide repeat-containing protein B7492_17755 ENOG4105XDF Protein of unknown function (DUF1272) B7492_17760 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) B7492_17765 ENOG4105CMG Carbohydrate kinase B7492_17780 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase B7492_17845 ENOG4105JAB phenazine biosynthesis protein, phzf family B7492_17860 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B7492_17865 ENOG4105KVH Transcriptional regulator B7492_17915 ENOG4108VXD carboxy-peptidase B7492_17945 ENOG4105F6J Alpha beta hydrolase fold B7492_17980 ENOG41080TC multidrug resistance protein B7492_18015 ENOG4107JM4 Tetratricopeptide repeat B7492_18045 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B7492_18055 ENOG4105EKQ RNA-directed DNA polymerase B7492_18255 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B7492_18265 ENOG4105DQ6 Transposase B7492_18330 ENOG4105BZU Histidine kinase B7492_18340 ENOG4105EKQ RNA-directed DNA polymerase B7492_18380 ENOG4108IND Tetr family transcriptional regulator B7492_18420 ENOG4105C44 Serine transporter B7492_18445 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) B7492_18470 ENOG4107R6D beta-lactam binding protein AmpH B7492_18480 ENOG4105H3G oxidoreductase B7492_18525 ENOG4105K7K Transcriptional regulator B7492_18530 ENOG4105CIS alcohol dehydrogenase B7492_18570 ENOG4108TN2 lmbE family B7492_18580 ENOG4107R3E Citrate transporter B7492_18605 ENOG4105NX3 Membrane B7492_18625 ENOG4107V2S Transcriptional regulator B7492_18655 ENOG4105C98 muts2 protein B7492_18670 ENOG4105E5K Alpha-amylase B7492_18675 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B7492_18680 ENOG4105DPN Oligoendopeptidase f B7492_18685 ENOG4105DWY Agmatine deiminase B7492_18705 ENOG4105FFC UPF0187 protein B7492_18720 ENOG4108A04 Beta-lactamase B7492_18735 ENOG4105EGI Transcriptional regulator B7492_18765 ENOG41082BM Transcriptional regulator, arsr family B7492_18770 ENOG4105CIS alcohol dehydrogenase B7492_18775 ENOG4105CNG UPF0061 protein B7492_18785 ENOG410780I phosphoprotein phosphatase activity B7492_18805 ENOG4105CQB FAD linked oxidase domain protein B7492_18825 ENOG4105KT7 mgtC SapB transporter B7492_18835 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B7492_18840 ENOG41073R8 VanW family B7492_18850 ENOG4108R1P B7492_18865 ENOG4105VEQ Cold shock protein B7492_18890 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B7492_18905 ENOG4105EKQ RNA-directed DNA polymerase B7492_18920 ENOG410904N short-chain dehydrogenase reductase B7492_18930 ENOG4106IQC argininosuccinate lyase B7492_18945 ENOG4108IA2 Sodium pantothenate symporter B7492_18955 ENOG4105C26 Dehydrogenase B7492_18960 ENOG4105CHR reductase B7492_18970 ENOG4105EWU Squalene--hopene cyclase B7492_18980 ENOG4105FR1 rard protein B7492_18985 ENOG410696E Membrane B7492_19045 ENOG4105CIG ABC transporter B7492_19055 ENOG4105D9R oxidoreductase B7492_19070 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B7492_19075 ENOG4105K4P CoA-binding domain protein B7492_19080 ENOG4105C0H protease B7492_19085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_19090 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) B7492_19095 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase B7492_19105 ENOG4105W8X HesB YadR YfhF-family protein B7492_19130 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B7492_19135 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B7492_19155 ENOG4108JJA ABC, transporter B7492_19160 ENOG4108I0Z Aconitate hydratase B7492_19190 ENOG4105E5W Transporter B7492_19200 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B7492_19220 ENOG4107F3J Amp-dependent synthetase and ligase B7492_19225 ENOG4107ZYJ bioY protein B7492_19230 ENOG4105CEY Amp-dependent synthetase and ligase B7492_19235 ENOG4108IMY Transcriptional regulator B7492_19275 ENOG4107AYK membrAne B7492_19290 ENOG4105BZU Histidine kinase B7492_19300 ENOG4105FBA Phospholipase Carboxylesterase B7492_19305 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase B7492_19315 ENOG4105CBC glutamate synthase B7492_19320 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B7492_19325 ENOG4108VJ1 Transcriptional regulator (CarD family B7492_19330 ENOG4108903 Formimidoylglutamase B7492_19340 ENOG4105CGP Urocanate hydratase B7492_19355 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) B7492_19390 ENOG4107QIV Cytochrome c biogenesis protein B7492_19400 ENOG4105CH2 amidohydrolase B7492_19405 ENOG4108TU7 Inherit from COG: (ABC) transporter B7492_19410 ENOG4105CJ1 ABC, transporter B7492_19420 ENOG4107RSM transcriptional regulator B7492_19430 ENOG41067MG lrgb family B7492_19450 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B7492_19470 ENOG4105BZ1 (ABC) transporter B7492_19475 ENOG4105BZ1 (ABC) transporter B7492_19515 ENOG4108HW3 (ABC) transporter B7492_19520 ENOG4105CGH 5'-nucleotidase B7492_19530 ENOG4108SVB resolvase B7492_19535 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B7492_19550 ENOG4105K7K Transcriptional regulator B7492_19555 ENOG4105BZ1 (ABC) transporter B7492_19575 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) B7492_19580 ENOG4105CAQ asparagine synthetase B7492_19585 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B7492_19595 ENOG4105CPF Cell wall formation (By similarity) B7492_19600 ENOG4105D3Q Sugar transferase B7492_19630 ENOG4108KMV Glycosyl transferase (Group 1 B7492_19635 ENOG41068W6 Capsular polysaccharide biosynthesis protein B7492_19640 ENOG4107SJB teichoic acid biosynthesis B7492_19645 ENOG4108KMV Glycosyl transferase (Group 1 B7492_19650 ENOG4108PQP glycosyl transferase group 1 B7492_19660 ENOG4107YJ4 chain length determinant protein B7492_19665 ENOG4105HTX biosynthesis protein B7492_19670 ENOG4105C5F glutamine synthetase B7492_19675 ENOG4105KV4 Transcriptional regulator B7492_19680 ENOG4105CXI aluminum resistance protein B7492_19685 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B7492_19690 ENOG4105EN6 Membrane B7492_19695 ENOG4106F1P AAA ATPase, central domain protein B7492_19720 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) B7492_19730 ENOG41069ER domain protein B7492_19735 ENOG4105DM4 PTS System B7492_19740 ENOG4105DE4 1-phosphofructokinase B7492_19745 ENOG4105E98 transcriptional regulator DeoR family B7492_19750 ENOG4107QW4 alcohol dehydrogenase B7492_19760 ENOG4107QW4 alcohol dehydrogenase B7492_19765 ENOG4108SJC Membrane B7492_19775 ENOG4105C85 amino acid B7492_19805 ENOG4105K70 DNA-binding protein B7492_19815 ENOG4105C59 p-type ATPase B7492_19820 ENOG410681U heavy metal transport detoxification protein B7492_19825 ENOG4105VPX protein, conserved in bacteria B7492_19845 ENOG4105NIV Esterase B7492_19850 ENOG4105E0A ABC, transporter B7492_19870 ENOG4105CGK Exodeoxyribonuclease III B7492_19880 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B7492_19885 ENOG4105D03 DNA-3-methyladenine glycosylase II B7492_19890 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) B7492_19910 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase B7492_19915 ENOG4105BZU Histidine kinase B7492_19960 ENOG41067MG lrgb family B7492_19975 ENOG4107YUH hydrolase B7492_19980 ENOG4107YEI lmbE family B7492_19990 ENOG4108S3Y transcriptional regulator B7492_19995 ENOG4105CS2 ec 3.2.1.21 B7492_20000 ENOG4105C8Q Methyl-accepting chemotaxis B7492_20005 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C B7492_20010 ENOG4105F0V Cell wall hydrolase B7492_20020 ENOG4105E0M Sulfatase B7492_20025 ENOG410890F Dynamin family B7492_20035 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) B7492_20040 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) B7492_20055 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B7492_20060 ENOG4105DQU oxidoreductase, subunit beta B7492_20065 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein B7492_20070 ENOG4108IGT Dipeptidase B7492_20075 ENOG4105MCT stage V sporulation protein S B7492_20080 ENOG4105D48 metallophosphoesterase B7492_20085 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) B7492_20110 ENOG4105CEV competence damage-inducible protein B7492_20115 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase B7492_20130 ENOG4105XZV Protein of unknown function (DUF3243) B7492_20135 ENOG4108RKS Short-chain dehydrogenase reductase Sdr B7492_20155 ENOG4105UIB (ABC) transporter B7492_20160 ENOG4108JQ9 ABC transporter B7492_20165 ENOG4105DIH basic membrane B7492_20170 ENOG4105FDP GntR family transcriptional regulator B7492_20180 ENOG4107QZI cell division protein FtsK B7492_20190 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit B7492_20200 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B7492_20210 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B7492_20215 ENOG4108S0H Dipicolinic acid synthetase, b subunit B7492_20220 ENOG4105E35 Dipicolinate synthase subunit A B7492_20230 ENOG4105C1V Peptidase, M16 B7492_20240 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) B7492_20250 ENOG4105DTN riboflavin biosynthesis protein ribF B7492_20265 ENOG4105W7A Protein of unknown function (DUF503) B7492_20270 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) B7492_20275 ENOG4105VHM ribosomal protein B7492_20280 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination B7492_20285 ENOG4105CHV Transcription elongation factor NusA B7492_20290 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) B7492_20295 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B7492_20300 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) B7492_20305 ENOG4105DZP Membrane-associated zinc metalloprotease B7492_20315 ENOG4105KNE Phosphatidate cytidylyltransferase B7492_20320 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) B7492_20325 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) B7492_20335 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) B7492_20340 ENOG4105CE9 30S ribosomal protein S2 B7492_20350 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) B7492_20355 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) B7492_20360 ENOG4108HE4 integrase family B7492_20365 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) B7492_20370 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) B7492_20375 ENOG4105C79 DNA protecting protein DprA B7492_20380 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha B7492_20390 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B7492_20395 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) B7492_20410 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) B7492_20415 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) B7492_20420 ENOG4105VB6 UPF0109 protein B7492_20435 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) B7492_20440 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) B7492_20445 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) B7492_20450 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) B7492_20455 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) B7492_20460 ENOG4105CHR reductase B7492_20465 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase B7492_20470 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) B7492_20480 ENOG4105CB5 ATP-dependent DNA helicase recG B7492_20485 ENOG4105DP4 dak2 domain fusion protein ylov B7492_20490 ENOG4108ZAA Alkaline-shock protein B7492_20505 ENOG4105FJ0 thiamine B7492_20510 ENOG4105DJV ribulose-phosphate 3-epimerase B7492_20520 ENOG4105D9P serine threonine protein kinase B7492_20525 ENOG4108ZF3 Phosphatase B7492_20530 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs B7492_20535 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B B7492_20540 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) B7492_20545 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B7492_20550 ENOG4105C25 Primosomal protein n' B7492_20555 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase B7492_20575 ENOG4105DSJ YicC domain protein B7492_20585 ENOG4105F23 Fibronectin-binding protein B7492_20595 ENOG4105DC7 peptidase M24 B7492_20640 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) B7492_20645 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) B7492_20650 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain B7492_20660 ENOG4105CD3 dihydroorotase B7492_20665 ENOG4105CXT aspartate transcarbamylase B7492_20675 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) B7492_20680 ENOG4105C34 Pseudouridine synthase B7492_20695 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) B7492_20705 ENOG4105DBK s4 domain protein B7492_20710 ENOG41067XK integral membrane protein B7492_20715 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) B7492_20720 ENOG4105DFA alanine racemase domain protein B7492_20725 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase B7492_20730 ENOG4105WR5 sporulation protein, YlmC YmxH family B7492_20740 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7492_20750 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) B7492_20755 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) B7492_20760 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) B7492_20770 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B7492_20775 ENOG4105CNI cell division protein FtsW B7492_20780 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) B7492_20785 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) B7492_20790 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) B7492_20795 ENOG4105CJN penicillin-binding protein B7492_20800 ENOG4105CJN penicillin-binding protein B7492_20810 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) B7492_20815 ENOG41074B2 UPF0747 protein B7492_20840 ENOG4105KNH Nucleic acid-binding protein B7492_20850 ENOG41063PX domain protein B7492_20855 ENOG4105D78 K07001 NTE family protein B7492_20860 ENOG4105H20 Sporulation integral membrane protein YlbJ B7492_20870 ENOG4106H78 methyltransferase B7492_20880 ENOG4105WUC UPF0298 protein B7492_20890 ENOG4107TB6 phosphoglycerate mutase B7492_20905 ENOG4106UY4 Inherit from COG: Scp-like extracellular B7492_20950 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) B7492_20960 ENOG4105CNI cell division protein FtsW B7492_20965 ENOG4105ZPI UPF0358 protein B7492_20975 ENOG4108IAB Phoh family B7492_20995 ENOG4105QA2 B7492_21000 ENOG4105CI3 gtp-binding protein typa B7492_21010 ENOG4105ECY inositol monophosphatase B7492_21020 ENOG4108WQ8 UPF0637 protein B7492_21025 ENOG4105WBI UPF0223 protein B7492_21030 ENOG4105CXN decarboxylase B7492_21080 ENOG4105C7S Dehydrogenase B7492_21085 ENOG4105CPP Dehydrogenase, E1 component B7492_21100 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B7492_21105 ENOG4108X4Q Hydrolase B7492_21120 ENOG4105CN5 Metallo-Beta-Lactamase B7492_21125 ENOG4107ZYR domain protein B7492_21140 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) B7492_21160 ENOG4108XRC Protein of unknown function (DUF458) B7492_21165 ENOG4107IN1 Protein of unknown function (DUF1797) B7492_21180 ENOG4105EPM Diguanylate phosphodiesterase B7492_21185 ENOG4105K6S Short-chain dehydrogenase reductase Sdr B7492_21200 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) B7492_21210 ENOG4105UIN B7492_21245 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) B7492_21265 ENOG4108HGU Histidine kinase B7492_21275 ENOG4105CHM Aminotransferase B7492_21285 ENOG4105FKQ transcriptional regulator B7492_21290 ENOG4105EG2 ABC transporter, permease B7492_21300 ENOG4107FKK extracellular solute-binding protein family 1 B7492_21310 ENOG4105CG3 alpha amylase, catalytic region B7492_21355 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) B7492_21360 ENOG4105CHU acetyl-coa acetyltransferase B7492_21395 ENOG4105K7K Transcriptional regulator B7492_21400 ENOG4105DTD Dehydrogenase B7492_21420 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B7492_21440 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) B7492_21460 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B7492_21470 ENOG4105BZU Histidine kinase B7492_21490 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) B7492_21505 ENOG4105CID antiterminator B7492_21515 ENOG4105FDP GntR family transcriptional regulator B7492_21525 ENOG4105CE4 GlcNAc 6-P deacetylase B7492_21535 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) B7492_21545 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) B7492_21565 ENOG4107ZE5 PPIases accelerate the folding of proteins B7492_21570 ENOG4105PTM secreted protein B7492_21575 ENOG4105J7I hydrolase B7492_21585 ENOG4105G6R Stage v sporulation protein ae B7492_21595 ENOG4105CZ3 stage V sporulation protein ad B7492_21600 ENOG41090VF Stage v sporulation protein ac B7492_21620 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7492_21630 ENOG41082AN stage II sporulation protein B7492_21635 ENOG4105DZ1 carboxypeptidase B7492_21640 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B7492_21645 ENOG4105DVE abc transporter atp-binding protein B7492_21680 ENOG4105D7N magnesium and cobalt transport protein CorA B7492_21695 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) B7492_21705 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B7492_21715 ENOG4105I3K Ferric uptake regulator, Fur family B7492_21720 ENOG4105MZ9 stage II sporulation protein m B7492_21740 ENOG4105CPC Aldo Keto reductase B7492_21750 ENOG4105RHY Pfam:UPF0157 B7492_21775 ENOG4107SKW Inherit from COG: Alpha beta hydrolase B7492_21785 ENOG4105ETE Transcriptional regulator (LacI family B7492_21790 ENOG4108YM7 Gcn5-related n-acetyltransferase B7492_21810 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) B7492_21815 ENOG4108R6K riboflavin synthase, subunit alpha B7492_21820 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) B7492_21840 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B7492_21845 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B7492_21850 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) B7492_21860 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7492_21875 ENOG4105DFD Na H antiporter B7492_21880 ENOG4105CGH 5'-nucleotidase B7492_21925 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase B7492_21935 ENOG4108IXY short-chain dehydrogenase reductase B7492_21940 ENOG41069FQ Metallo-beta-lactamase superfamily B7492_21945 ENOG4105II7 pyrroline-5-carboxylate reductase B7492_21950 ENOG4105EJQ L-serine dehydratase B7492_21965 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) B7492_21975 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic B7492_21990 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B7492_21995 ENOG4105D9U N-acetyltransferase B7492_22005 ENOG4108VZI ErfK ybiS ycfS ynhG family protein B7492_22010 ENOG4108QEG Membrane B7492_22015 ENOG4105CDA abc transporter atp-binding protein B7492_22020 ENOG4105E5Q amino acid AbC transporter B7492_22025 ENOG4108HW3 (ABC) transporter B7492_22035 ENOG4105E09 nadh pyrophosphatase B7492_22040 ENOG4108QY0 Membrane B7492_22050 ENOG4105C7S Dehydrogenase B7492_22055 ENOG4105CPP Dehydrogenase, E1 component B7492_22075 ENOG4107RDP Dehydrogenase B7492_22090 ENOG4108JUB Transcriptional regulator B7492_22095 ENOG4106CCJ Protein of unknown function (DUF2627) B7492_22100 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B7492_22115 ENOG4107QQR Sporulation B7492_22125 ENOG4105S1Z Stage IV sporulation protein B B7492_22130 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) B7492_22140 ENOG4105DX0 Hemolysin A B7492_22145 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) B7492_22150 ENOG4105CTB Polyprenyl synthetase B7492_22155 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B7492_22160 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B7492_22165 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) B7492_22170 ENOG4105M7K Involved in the transcription termination process (By similarity) B7492_22175 ENOG4108ZSR alkaline shock protein B7492_22180 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B7492_22205 ENOG410644B Stage III sporulation protein af B7492_22215 ENOG4105KQ4 Stage iii sporulation protein ad B7492_22220 ENOG4108CQH stage III sporulation protein AC B7492_22225 ENOG4105KR5 Stage iii sporulation protein B7492_22230 ENOG4105CD2 stage iii sporulation protein aa B7492_22250 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) B7492_22255 ENOG4105DC7 peptidase M24 B7492_22260 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) B7492_22270 ENOG4105CBJ Metal-dependent enzyme B7492_22280 ENOG4107YBY Hydrolase B7492_22315 ENOG41082GG biotin lipoate A B protein ligase B7492_22320 ENOG4105WZW rhodanese family B7492_22345 ENOG41080TC multidrug resistance protein B7492_22380 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B7492_22395 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor B7492_22400 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor B7492_22405 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) B7492_22410 ENOG4105C0D helicase B7492_22440 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) B7492_22535 ENOG4105CYP glycoside hydrolase, family B7492_22545 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B7492_22555 ENOG4105CAR Terminase, large subunit B7492_22665 ENOG4105KRN Transcriptional regulator, abrb family B7492_22720 ENOG41067QW Transcriptional regulator B7492_22815 ENOG4105C3R Methionine synthase B7492_22825 ENOG4105C28 cystathionine B7492_22830 ENOG4105C28 cystathionine B7492_22845 ENOG4105C5X domain protein B7492_22855 ENOG4105DKQ ROK family B7492_22865 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase B7492_22880 ENOG4108UTW Plays a role in the regulation of phosphate uptake B7492_22885 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B7492_22890 ENOG4105E2Z phosphate ABC transporter (Permease B7492_22895 ENOG4105C8U phosphate abc transporter B7492_22900 ENOG4105PWN phosphate abc transporter B7492_22905 ENOG4107RF6 penicillin-binding protein B7492_22915 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B7492_22940 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) B7492_22945 ENOG4105N80 Ferric uptake regulator, Fur family B7492_22955 ENOG4105FDK ABC transporter B7492_22960 ENOG4108JYZ YitT family B7492_22965 ENOG41069ZM Protein of unknown function (DUF2624) B7492_22985 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) B7492_22990 ENOG4105EGD dinuclear metal center protein, YbgI family B7492_23005 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7492_23010 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) B7492_23030 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) B7492_23040 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) B7492_23045 ENOG4105KG3 cytidine deaminase B7492_23050 ENOG4107YR5 Diacylglycerol kinase B7492_23055 ENOG4107YVF Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) B7492_23060 ENOG4105CTJ Metal Dependent Phosphohydrolase B7492_23065 ENOG4105C9A Phoh family B7492_23075 ENOG41068P3 sporulation protein YqfC B7492_23080 ENOG4105KTH gatB Yqey B7492_23090 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B7492_23095 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) B7492_23105 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) B7492_23115 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ B7492_23125 ENOG4105CSA Coproporphyrinogen iii oxidase B7492_23130 ENOG4105KVH Transcriptional regulator B7492_23135 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) B7492_23145 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) B7492_23150 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) B7492_23155 ENOG4105TQK DNA polymerase iii, delta' subunit B7492_23165 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 B7492_23170 ENOG4108UK2 deaminase B7492_23175 ENOG4105KQC Competence protein B7492_23185 ENOG4105DXX methyltransferase B7492_23195 ENOG4108WF2 Metal Dependent Phosphohydrolase B7492_23200 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) B7492_23205 ENOG410812S Rna-binding protein B7492_23210 ENOG4105E2X shikimate dehydrogenase B7492_23215 ENOG4105CQW ribosome biogenesis GTPase YqeH B7492_23220 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase B7492_23230 ENOG4105DJ4 phosphatidylserine decarboxylase B7492_23235 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7492_23260 ENOG4105G6Z alkaline phosphatase B7492_23270 ENOG4108MUZ hydrolase B7492_23305 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin B7492_23310 ENOG4105MIR Phenylalanine 4-monooxygenase B7492_23315 ENOG4105KZX Pterin carbinolamine dehydratase B7492_23325 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B7492_23365 ENOG4105S6R Iron-hydroxamate transporter permease subunit B7492_23370 ENOG4108V5C ABC transporter B7492_23385 ENOG4108EKI Dehydrogenase B7492_23390 ENOG4105C28 cystathionine B7492_23400 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B7492_23420 ENOG4107XRG penicillin-binding protein B7492_23430 ENOG4105DBI uridine monophosphokinase B7492_23435 ENOG4105CFP Peptidase U32 B7492_23440 ENOG4105XYU peptidase (U32 family) B7492_23445 ENOG4108VQJ O-methyltransferase B7492_23450 ENOG4105HHA aminodeoxychorismate lyase B7492_23460 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) B7492_23470 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B7492_23480 ENOG4105C02 permease B7492_23495 ENOG41060CR B7492_23500 ENOG4105C7H Helicase, RecD TraA family B7492_23510 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) B7492_23515 ENOG4105C3J Cysteine desulfurase B7492_23525 ENOG4105D1H recombination factor protein RarA B7492_23530 ENOG4108VCI transcription factor, rsfa family B7492_23535 ENOG4105CUZ uba thif-type nad fad binding protein B7492_23545 ENOG4105CUT histidyl-tRNA synthetase B7492_23550 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) B7492_23555 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B7492_23560 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) B7492_23565 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) B7492_23570 ENOG41076HS cation diffusion facilitator family transporter B7492_23575 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) B7492_23585 ENOG4105CKP Polysaccharide Biosynthesis Protein B7492_23590 ENOG4108QG2 Membrane B7492_23600 ENOG4105VIE preprotein translocase, subunit YajC B7492_23605 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) B7492_23610 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) B7492_23615 ENOG41061AI Protein of unknown function (DUF2905) B7492_23620 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) B7492_23625 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) B7492_23630 ENOG4108HUF Transporter B7492_23655 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) B7492_23660 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase B7492_23665 ENOG4108IYU L-aspartate oxidase B7492_23680 ENOG4108RPX mosc domain containing protein B7492_23685 ENOG4105CQC Prephenate dehydratase B7492_23700 ENOG4105C19 ABC transporter B7492_23705 ENOG4105EWM Histidine kinase B7492_23715 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control B7492_23730 ENOG4105X36 (ribosomal) protein B7492_23740 ENOG4105C03 ribonuclease B7492_23755 ENOG4107QMS site-determining protein B7492_23760 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) B7492_23770 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) B7492_23775 ENOG4105DFF Rod shape-determining protein mreb B7492_23815 ENOG4105W5Q DNA repair protein (RadC B7492_23820 ENOG4108Z03 MAF-like protein B7492_23835 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase B7492_23840 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) B7492_23850 ENOG41068KH stage VI sporulation protein D B7492_23855 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase B7492_23860 ENOG4105D52 delta-aminolevulinic acid dehydratase B7492_23870 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) B7492_23880 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) B7492_23885 ENOG4105K56 Transcriptional regulator B7492_23895 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) B7492_23905 ENOG4108IUQ atp-dependent protease B7492_23915 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation B7492_23930 ENOG4108QCI YvbH-like oligomerisation region B7492_23945 ENOG4105M59 Phosphodiesterase, mj0936 family B7492_23955 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) B7492_23960 ENOG4108XJQ germination protein B7492_23970 ENOG4105PFC Transcriptional regulator B7492_23980 ENOG4105DZC cytosine deaminase B7492_23985 ENOG41067S9 phage shock protein C, PspC B7492_23990 ENOG4108JCI Transcriptional regulator B7492_24000 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) B7492_24005 ENOG4108Z40 Transcriptional regulator B7492_24010 ENOG4105RHA ABC transporter, permease B7492_24015 ENOG4108IUX (ABC) transporter B7492_24020 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family B7492_24025 ENOG4105ER2 Ompa motb domain protein B7492_24030 ENOG4105E14 MotA TolQ exbB proton channel B7492_24040 ENOG4108VXD carboxy-peptidase B7492_24050 ENOG4105E33 succinate dehydrogenase B7492_24060 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit B7492_24070 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) B7492_24075 ENOG4105K63 Thioredoxin B7492_24080 ENOG4105C10 Electron transfer flavoprotein B7492_24085 ENOG4105BZJ Electron transfer flavoprotein B7492_24090 ENOG41060WC Enoyl-CoA hydratase B7492_24095 ENOG4107Z3H Transcriptional regulator, TetR family B7492_24100 ENOG4105CEY Amp-dependent synthetase and ligase B7492_24110 ENOG4105J76 Periplasmic binding protein B7492_24115 ENOG4105S6R Iron-hydroxamate transporter permease subunit B7492_24155 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7492_24165 ENOG4105DR4 Methyltransferase B7492_24170 ENOG4105P9G heme-degrading monooxygenase IsdG B7492_24175 ENOG4105KFN sortase, SrtB family B7492_24180 ENOG4105E0A ABC, transporter B7492_24195 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) B7492_24205 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) B7492_24215 ENOG4105FE9 pseudouridine synthase B7492_24220 ENOG4105C98 muts2 protein B7492_24225 ENOG4105DCG PHP domain protein B7492_24235 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) B7492_24240 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B7492_24255 ENOG4105C5S asparaginyl-tRNA synthetase B7492_24260 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) B7492_24265 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) B7492_24270 ENOG4108RWN rrna methyltransferase B7492_24300 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7492_24305 ENOG4105CW7 secretion protein, HlyD family B7492_24310 ENOG4108JGH Tetr family transcriptional regulator B7492_24315 ENOG4105CN9 Peptidase m42 family protein B7492_24325 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) B7492_24335 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) B7492_24340 ENOG4105C22 threonyL-tRNA synthetase B7492_24345 ENOG4108TDW sporulation protein YtxC B7492_24365 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B7492_24370 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B7492_24375 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) B7492_24385 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) B7492_24390 ENOG4105C2M dna polymerase I B7492_24395 ENOG4105BZU Histidine kinase B7492_24400 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7492_24415 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B7492_24420 ENOG4108HMX isocitrate dehydrogenase (NADP) B7492_24425 ENOG4105BZN citrate synthase B7492_24440 ENOG4108REF Sporulation integral membrane protein ytvi B7492_24445 ENOG4105FS0 cytoplasmic membrane protein B7492_24455 ENOG4105CTQ phosphohexokinase B7492_24465 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) B7492_24470 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family B7492_24475 ENOG4105C6K Malic enzyme B7492_24480 ENOG4105C0B DNA polymerase III (alpha subunit) B7492_24485 ENOG4105VV2 B7492_24495 ENOG4105SFS phosphoesterase RecJ domain protein B7492_24520 ENOG4105E8R UPF0173 metal-dependent hydrolase B7492_24525 ENOG4105DC7 peptidase M24 B7492_24565 ENOG41082W1 Cupin 2, conserved barrel domain protein B7492_24570 ENOG4105VZ8 Transcriptional regulator B7492_24590 ENOG4107YZX Universal stress protein B7492_24605 ENOG4105CH7 arginosuccinase B7492_24610 ENOG4105CDH Citrulline--aspartate ligase B7492_24625 ENOG4108JYZ YitT family B7492_24640 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) B7492_24650 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) B7492_24655 ENOG4105KBJ sporulation protein ytfj B7492_24675 ENOG4105EFZ amidohydrolase B7492_24685 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B7492_24725 ENOG4105U5Y Transcriptional regulator B7492_24735 ENOG4105C28 cystathionine B7492_24740 ENOG4105D7V transposase B7492_24745 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) B7492_24785 ENOG4108IBT Inherit from COG: transposase B7492_24880 ENOG4105EMN RNA polymerase sigma factor B7492_24890 ENOG4108UW5 maltose o-acetyltransferase B7492_24900 ENOG4105F1V Acetoin utilization protein B7492_24905 ENOG4105W87 Cbs domain B7492_24910 ENOG4105DGU Histone deacetylase B7492_24930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_24935 ENOG4105BZU Histidine kinase B7492_24940 ENOG4107SNB ankyrin repeat protein YahD B7492_24945 ENOG4105EP9 oxidoreductase B7492_24950 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) B7492_24975 ENOG4105ETE Transcriptional regulator (LacI family B7492_25000 ENOG4105C88 aminopeptidase B7492_25025 ENOG4105DFU Cell wall formation (By similarity) B7492_25050 ENOG4108VDD TRNA binding domain protein B7492_25080 ENOG4105C8F Beta-lactamase domain protein B7492_25085 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) B7492_25095 ENOG4108V15 phosphotransferase enzyme family B7492_25100 ENOG4108IUM Glycogen debranching enzyme B7492_25110 ENOG4107QSE Dipeptidase B7492_25115 ENOG4105YW5 deoR family transcriptional regulator B7492_25130 ENOG4105CBX hi0933 family B7492_25170 ENOG4108VJ1 Transcriptional regulator (CarD family B7492_25175 ENOG4107EXU Short-chain dehydrogenase reductase Sdr B7492_25195 ENOG4108ZAF Molybdopterin B7492_25200 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein B7492_25205 ENOG4105CVM Molybdenum cofactor synthesis domain protein B7492_25215 ENOG4105D06 uba thif-type nad fad binding protein B7492_25220 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B7492_25245 ENOG41085GJ domain protein B7492_25255 ENOG4105DWV Homoserine O-trans-acetylase B7492_25265 ENOG4108B31 Spore germination protein B7492_25300 ENOG410605W Major Facilitator B7492_25305 ENOG4107S91 Sodium hydrogen exchanger B7492_25310 ENOG4105NCW Trka-c domain protein B7492_25325 ENOG4105C19 ABC transporter B7492_25345 ENOG4105N5T Radical SAM Protein B7492_25355 ENOG4105DA5 (ABC) transporter B7492_25380 ENOG4105E8V Alpha Beta Hydrolase Fold protein B7492_25385 ENOG4108Z0R Transferase B7492_25390 ENOG4105YVM Phosphoesterase, PA-phosphatase related B7492_25395 ENOG4105BZF Glycosyl transferase (Group 1 B7492_25400 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) B7492_25405 ENOG4105EPU Molybdenum cofactor synthesis domain protein B7492_25420 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP B7492_25425 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase B7492_25450 ENOG4105BZU Histidine kinase B7492_25455 ENOG4105BZU Histidine kinase B7492_25460 ENOG4105CH6 catalase B7492_25465 ENOG4107S9D Alpha beta hydrolase B7492_25480 ENOG4107T7U Sulfatase B7492_25505 ENOG4105D2X ABC transporter substrate-binding protein B7492_25515 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component B7492_25530 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) B7492_25590 ENOG41080TC multidrug resistance protein B7492_25595 ENOG410839T multidrug resistance protein B7492_25615 ENOG4108V2W Carbonate dehydratase B7492_25645 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B7492_25650 ENOG4105XSJ toxin secretion phage lysis holin B7492_25660 ENOG4105EKQ RNA-directed DNA polymerase B7492_25730 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B7492_25740 ENOG4105CAR Terminase, large subunit B7492_25850 ENOG4105YQ0 B7492_25905 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B7492_25950 ENOG41087YS Phage shock protein A B7492_25975 ENOG4105N67 Proton-coupled thiamine transporter YuaJ B7492_25980 ENOG4105BZU Histidine kinase B7492_25985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_26010 ENOG4108UGV hypoxanthine phosphoribosyltransferase B7492_26015 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) B7492_26050 ENOG4107VMI polysaccharide deacetylase B7492_26070 ENOG4105BZU Histidine kinase B7492_26100 ENOG4105C19 ABC transporter B7492_26105 ENOG41086D8 Transcriptional regulator B7492_26115 ENOG4105CJ1 ABC, transporter B7492_26125 ENOG41082BM Transcriptional regulator, arsr family B7492_26165 ENOG4105C6Z Gluconate B7492_26170 ENOG4105FDP GntR family transcriptional regulator B7492_26190 ENOG41069H0 dihydroorotase EC 3.5.2.3 B7492_26210 ENOG4105DTQ mandelate racemase muconate lactonizing B7492_26215 ENOG4105CEY Amp-dependent synthetase and ligase B7492_26220 ENOG4108IPT Naphthoate synthase B7492_26225 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) B7492_26230 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) B7492_26235 ENOG4105E4F Isochorismate synthase B7492_26240 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase B7492_26250 ENOG4105VEQ Cold shock protein B7492_26265 ENOG4107SWG transcriptional regulator MERR family B7492_26290 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) B7492_26300 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B7492_26315 ENOG4105JVQ RNA Polymerase B7492_26455 ENOG4105KT7 mgtC SapB transporter B7492_26460 ENOG4107PBV potassium channel B7492_26470 ENOG4107S5H glucose-6-phosphate isomerase B7492_26480 ENOG4105WG9 Conserved Protein B7492_26490 ENOG4105CHM Aminotransferase B7492_26495 ENOG4108ZB6 transcriptional regulator AsnC family B7492_26500 ENOG4105C5I Dehydrogenase B7492_26505 ENOG4108MUZ hydrolase B7492_26515 ENOG4105C87 Aminotransferase class I and II B7492_26525 ENOG4105Y38 Kinase-associated protein B B7492_26535 ENOG4107R3E Citrate transporter B7492_26550 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) B7492_26555 ENOG4105KA0 thioesterase Superfamily protein B7492_26570 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B7492_26585 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) B7492_26590 ENOG41069ER domain protein B7492_26605 ENOG4105CEP NADH dehydrogenase B7492_26630 ENOG4105EWC Purine nucleoside phosphorylase B7492_26650 ENOG4108YX9 iron--sulfur cluster insertion protein erpA B7492_26655 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) B7492_26670 ENOG4108JJA ABC, transporter B7492_26675 ENOG4105C4B ABC transporter, permease B7492_26680 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA B7492_26700 ENOG41083MR nifu domain-containing protein B7492_26725 ENOG4108W5N phosphatidylglycerophosphatase a B7492_26745 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7492_26750 ENOG4105DYS nad(p)h dehydrogenase (quinone) B7492_26760 ENOG4105D4U had-superfamily hydrolase, subfamily iia B7492_26775 ENOG4105CBT Fructose-1,6-bisphosphatase B7492_26800 ENOG4105MMD transcriptional regulator B7492_26805 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) B7492_26810 ENOG4107TXC Transcriptional regulator B7492_26815 ENOG41090T1 Membrane B7492_26835 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) B7492_26840 ENOG4105FAA peptidase M23 B7492_26845 ENOG4108YTE sporulation protein YunB B7492_26850 ENOG4105KZD Domain of unknown function (DUF1805) B7492_26855 ENOG4107R8B 5'-nucleotidase B7492_26860 ENOG4105DIW FeS assembly protein SUFB B7492_26865 ENOG4108UNV SUF system FeS assembly protein, NifU family B7492_26870 ENOG4105C9B Cysteine desulfurase B7492_26875 ENOG4105JRK feS assembly protein SufD B7492_26880 ENOG4105C3K feS assembly ATPase SufC B7492_26885 ENOG4105D01 (LipO)protein B7492_26890 ENOG4105D01 (LipO)protein B7492_26895 ENOG4108UMI ABC transporter, permease B7492_26925 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) B7492_26930 ENOG41080E8 Transcriptional regulator, Spx MgsR family B7492_26980 ENOG4108W8B Beta-lactamase domain protein B7492_26985 ENOG4105C1G acyl-Coa dehydrogenase B7492_26990 ENOG4105CHU acetyl-coa acetyltransferase B7492_27005 ENOG4105DZ1 carboxypeptidase B7492_27025 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B7492_27035 ENOG4108SUT Major Facilitator Superfamily B7492_27040 ENOG4107R7I amino acid B7492_27055 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins B7492_27065 ENOG4107AYK membrAne B7492_27140 ENOG4107ZTW SNARE associated Golgi B7492_27150 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein B7492_27155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_27160 ENOG4105BZU Histidine kinase B7492_27170 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) B7492_27180 ENOG4105C8Q Methyl-accepting chemotaxis B7492_27185 ENOG4105C8Q Methyl-accepting chemotaxis B7492_27190 ENOG4105VG1 fes assembly suf system protein B7492_27195 ENOG4105D4Y metalloprotease B7492_27215 ENOG4107T5V SNARE associated Golgi B7492_27220 ENOG4107S91 Sodium hydrogen exchanger B7492_27225 ENOG4105NCW Trka-c domain protein B7492_27235 ENOG4108RMU ferritin dps family protein B7492_27250 ENOG4108URH decarboxylase B7492_27260 ENOG41090A1 ferritin B7492_27265 ENOG4105DHF Membrane B7492_27275 ENOG4105D9N nucleoside B7492_27280 ENOG4105D9N nucleoside B7492_27290 ENOG4108RYK Nad-dependent epimerase dehydratase B7492_27320 ENOG4105CV8 reductase B7492_27325 ENOG4105F27 Major Facilitator B7492_27330 ENOG4105KVH Transcriptional regulator B7492_27345 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B7492_27350 ENOG4105D4A Cell wall formation (By similarity) B7492_27375 ENOG4105C8Q Methyl-accepting chemotaxis B7492_27385 ENOG4105WMR Protein CrcB homolog B7492_27410 ENOG4105C5H ABC transporter B7492_27415 ENOG4108MK9 spermidine N(1)-acetyltransferase B7492_27425 ENOG4108VY7 phosphate-starvation-inducible protein PsiE B7492_27430 ENOG4108W2Y isochorismatase B7492_27450 ENOG4108V2W Carbonate dehydratase B7492_27455 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) B7492_27475 ENOG4108IPW abc transporter atp-binding protein B7492_27480 ENOG4105CM4 permease protein B7492_27515 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) B7492_27525 ENOG4105XZU Preprotein translocase, subunit SecG B7492_27530 ENOG41067MG lrgb family B7492_27540 ENOG4105DU0 nucleoside hydrolase B7492_27545 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) B7492_27555 ENOG4105CP7 Triose-phosphate isomerase B7492_27560 ENOG4105BZA Phosphoglycerate kinase B7492_27580 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7492_27610 ENOG41090VF Stage v sporulation protein ac B7492_27615 ENOG4105CZ3 stage V sporulation protein ad B7492_27630 ENOG4108QY0 Membrane B7492_27635 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B7492_27640 ENOG4105KRI phosphocarrier protein (HPr B7492_27645 ENOG4105CIE May be required for sporulation (By similarity) B7492_27650 ENOG4105CHW UPF0052 protein B7492_27655 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) B7492_27660 ENOG4108Z4K mutator MutT protein B7492_27670 ENOG4105C3M thioredoxin reductase B7492_27680 ENOG4108S4C acetyltransferase B7492_27685 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) B7492_27690 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) B7492_27695 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) B7492_27700 ENOG41086DT Membrane protein of unknown function B7492_27710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B7492_27730 ENOG4107TXC Transcriptional regulator B7492_27765 ENOG4105DUM transcriptional regulator, lysR family B7492_27770 ENOG4108Z6Z Transcriptional regulator B7492_27775 ENOG4108WS4 fmn reductase B7492_27790 ENOG4105BZ1 (ABC) transporter B7492_27800 ENOG4105CN1 protease B7492_27805 ENOG4105CRP Part of the ABC transporter FtsEX involved in B7492_27810 ENOG4105CAK Cell division ATP-binding protein ftsE B7492_27825 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) B7492_27850 ENOG4105MS2 ribosomal subunit Interface protein B7492_27855 ENOG4105VEQ Cold shock protein B7492_27860 ENOG41081UC Inherit from COG: Competence protein B7492_27875 ENOG4105KVH Transcriptional regulator B7492_27885 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein B7492_27890 ENOG4108KGH TRANSCRIPTIONal B7492_27895 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase B7492_27900 ENOG4105C6Y Udp-glucose 6-dehydrogenase B7492_27905 ENOG4105ESV Glycosyl transferase, family 4 B7492_27915 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family B7492_27935 ENOG4105F8D glycoside hydrolase family 4 B7492_27940 ENOG4105VCP PTS System B7492_27945 ENOG4105CK1 PTS System B7492_27950 ENOG4105VZJ PTS System B7492_27955 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) B7492_27960 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B7492_27975 ENOG4105VCP PTS System B7492_27985 ENOG4105VZJ PTS System B7492_28010 ENOG4105ECB domain protein B7492_28015 ENOG4107RSM transcriptional regulator B7492_28040 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) B7492_28045 ENOG4105DAA L-lactate B7492_28055 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) B7492_28070 ENOG4105E0M Sulfatase B7492_28085 ENOG4105D9N nucleoside B7492_28095 ENOG4107R8N Glycosyl transferase, family 2 B7492_28100 ENOG4105C94 Transporter B7492_28110 ENOG41069ER domain protein B7492_28135 ENOG4105KBK Zinc finger, swim domain protein B7492_28140 ENOG4105C0D helicase B7492_28170 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7492_28180 ENOG4107RBB ABC transporter, permease B7492_28185 ENOG4105C19 ABC transporter B7492_28195 ENOG4105CXY transporter B7492_28210 ENOG41062D9 Histidine kinase B7492_28215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_28220 ENOG4105CMR udp-glucose 4-epimerase B7492_28230 ENOG4108KGH TRANSCRIPTIONal B7492_28235 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase B7492_28240 ENOG4105C1B dTDP-glucose 4-6-dehydratase B7492_28245 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase B7492_28250 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase B7492_28255 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) B7492_28260 ENOG4107SJB teichoic acid biosynthesis B7492_28290 ENOG4105D3Q Sugar transferase B7492_28295 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B7492_28300 ENOG4108RB3 Capsular polysaccharide biosynthesis protein B7492_28305 ENOG4107YJ4 chain length determinant protein B7492_28310 ENOG4105HTX biosynthesis protein B7492_28315 ENOG4107YJ4 chain length determinant protein B7492_28330 ENOG4105MT0 Sporulation transcriptional regulator spoiiid B7492_28340 ENOG4105FRN stage II sporulation protein B7492_28355 ENOG4105DY9 regulatoR B7492_28375 ENOG4106778 Protein of unknown function (DUF1146) B7492_28380 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7492_28385 ENOG4105C8S subunit m B7492_28390 ENOG4105D65 subunit l B7492_28395 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7492_28410 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) B7492_28415 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7492_28420 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain B7492_28425 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B7492_28430 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain B7492_28435 ENOG4105BZU Histidine kinase B7492_28455 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) B7492_28460 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) B7492_28465 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) B7492_28470 ENOG4107XXH F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) B7492_28475 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) B7492_28485 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) B7492_28490 ENOG41062M3 atp synthase B7492_28510 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) B7492_28520 ENOG4108YZG isomerase B7492_28535 ENOG4108VGI doxx family B7492_28540 ENOG4107XC4 flavin reductase domain protein, FMN-binding B7492_28555 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B7492_28565 ENOG4108ZXQ stage ii sporulation protein r B7492_28570 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) B7492_28580 ENOG4107104 thymidine kinase B7492_28595 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) B7492_28600 ENOG4105CBT Fructose-1,6-bisphosphatase B7492_28605 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B7492_28625 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) B7492_28640 ENOG4105C1G acyl-Coa dehydrogenase B7492_28645 ENOG4105C1G acyl-Coa dehydrogenase B7492_28650 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B7492_28660 ENOG4105DF6 Fe-S oxidoreductase B7492_28670 ENOG4105E5J UV damage endonuclease B7492_28675 ENOG4105BZU Histidine kinase B7492_28690 ENOG4105D4Y metalloprotease B7492_28700 ENOG4105BZU Histidine kinase B7492_28705 ENOG4105KCT ABC transporter B7492_28710 ENOG4108M15 ABC transporter B7492_28715 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) B7492_28725 ENOG4105IIU Aminopeptidase B7492_28745 ENOG410684U Domain of unknown function (DUF1934) B7492_28770 ENOG4105CYW agmatinase B7492_28775 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) B7492_28780 ENOG4105DXB Major Facilitator superfamily B7492_28785 ENOG4107SWG transcriptional regulator MERR family B7492_28790 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B7492_28795 ENOG4105BZ4 penicillin-binding protein B7492_28800 ENOG4108XFG YwhD family B7492_28805 ENOG4108Z4T Peptidase M50 B7492_28810 ENOG41069HH 4-oxalocrotonate tautomerase B7492_28815 ENOG4105DCI Phosphohydrolase B7492_28820 ENOG4108MES Periplasmic binding protein B7492_28825 ENOG4105E0A ABC, transporter B7492_28830 ENOG4105EHG Permease protein B7492_28835 ENOG4105DQ5 transport system permease protein B7492_28845 ENOG4108VCI transcription factor, rsfa family B7492_28850 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) B7492_28855 ENOG4108IJ2 phosphate acetyltransferase B7492_28860 ENOG4107JTW chlorite dismutase B7492_28870 ENOG4108VKI Cell wall hydrolase B7492_28900 ENOG410667J hydrolase B7492_28905 ENOG4105VCH membrane B7492_28910 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) B7492_28915 ENOG4108TU7 Inherit from COG: (ABC) transporter B7492_28920 ENOG4105CJ1 ABC, transporter B7492_28925 ENOG41090WU lipolytic protein G-D-S-L family B7492_28945 ENOG4105D6E homoserine dehydrogenase B7492_28950 ENOG4105CVG Homoserine O-transsuccinylase B7492_28975 ENOG4108Y4K DNA-binding transcriptional activator B7492_28985 ENOG4105WH1 Two component transcriptional regulator luxr family B7492_28990 ENOG4105BZU Histidine kinase B7492_28995 ENOG4105DWF phosphomethylpyrimidine kinase B7492_29005 ENOG4105VCD cytoplasmic protein B7492_29010 ENOG4105D22 carbon starvation protein B7492_29015 ENOG4105DY9 regulatoR B7492_29020 ENOG41079KZ Major Facilitator Superfamily B7492_29030 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) B7492_29040 ENOG4105EN6 Membrane B7492_29045 ENOG4106YBV Methyl-accepting chemotaxis B7492_29055 ENOG4108S4H thioesterase Superfamily protein B7492_29060 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) B7492_29075 ENOG4105K64 Glycosyl transferase, family 2 B7492_29085 ENOG4105C5H ABC transporter B7492_29090 ENOG41067SE Tetr family transcriptional regulator B7492_29100 ENOG4105E0X reductase B7492_29105 ENOG4106F5Q Membrane B7492_29115 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) B7492_29120 ENOG4105DY9 regulatoR B7492_29125 ENOG4108HRK Histidine kinase B7492_29130 ENOG4107RGD Major Facilitator superfamily B7492_29150 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B7492_29160 ENOG4105IW1 AmiS UreI transporter B7492_29200 ENOG4105CMR udp-glucose 4-epimerase B7492_29205 ENOG4108UT2 hemolysin iii B7492_29215 ENOG4105C1J atp-dependent rna helicase B7492_29230 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) B7492_29235 ENOG4105DPN Oligoendopeptidase f B7492_29245 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) B7492_29255 ENOG4105C0H protease B7492_29260 ENOG4105Q2H domain protein B7492_29275 ENOG4105BZU Histidine kinase B7492_29280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_29305 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis B7492_29310 ENOG4105CDU Replicative dna helicase B7492_29315 ENOG4105K9Q Binds to the 23S rRNA (By similarity) B7492_29320 ENOG4105BZR domain protein B7492_29325 ENOG4108XMW Membrane B7492_29335 ENOG4108UUM single-stranded DNA-binding protein B7492_29340 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) B7492_29345 ENOG4105C3G gtp-binding protein B7492_29350 ENOG4105VDK protein, conserved in bacteria B7492_29355 ENOG4105D8X mechanosensitive ion channel B7492_29360 ENOG4108ZDA Sporulation protein YyaC B7492_29365 ENOG4105FA0 parb-like partition protein B7492_29370 ENOG4107QJE Chromosome Partitioning Protein B7492_29375 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) B7492_29385 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) B7492_29390 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) B7492_29400 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins B7492_29405 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) B7492_29420 ENOG4105VTR Integrase B7492_29490 ENOG4105ED2 Beta-lactamase B7492_29510 ENOG4105FQP Beta-lactamase B7492_29530 ENOG4105CZV ABC transporter B7492_29535 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family B7492_29550 ENOG4105D7V transposase B7492_29560 ENOG4105DQ6 Transposase B7492_29575 ENOG4105W1Y Transcriptional regulator B7492_29580 ENOG41067QW Transcriptional regulator B7492_29605 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B7492_29680 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) B7492_29750 ENOG4105GZI Transcriptional regulator B7492_29755 ENOG4108RWP Major Facilitator Superfamily protein B7492_29765 ENOG4105CJW magnesium transporter B7492_29770 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic B7492_29775 ENOG4108NHD germination protein B7492_29785 ENOG4105E1K spore germination protein B7492_29885 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) B7492_29905 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B7492_29965 ENOG4105CJW magnesium transporter B7492_29970 ENOG4105CNI cell division protein FtsW B7492_29995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_30040 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B7492_30080 ENOG4106A3M Cytochrome p-450 B7492_30085 ENOG410625E B7492_30120 ENOG4105C8Q Methyl-accepting chemotaxis B7492_30125 ENOG4107VMI polysaccharide deacetylase B7492_30140 ENOG4108IMY Transcriptional regulator B7492_30165 ENOG4105EKQ RNA-directed DNA polymerase B7492_30215 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein B7492_30225 ENOG4105CJZ response regulator B7492_30260 ENOG4105C44 Serine transporter B7492_30265 ENOG4105EJQ L-serine dehydratase B7492_30275 ENOG4105YWU small acid-soluble spore protein B7492_30305 ENOG4105D7V transposase B7492_30320 ENOG4105KD7 acetyltransferase B7492_30325 ENOG4105MWK D-amino acid dehydrogenase, small subunit B7492_30335 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) B7492_30340 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) B7492_30345 ENOG4105CYW agmatinase B7492_30350 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain B7492_30355 ENOG4106048 Cupin 2, conserved barrel domain protein B7492_30360 ENOG4108KF3 Electron transport protein SCO1 SenC B7492_30435 ENOG4105DQ6 Transposase B7492_30450 ENOG4107SWG transcriptional regulator MERR family B7492_30455 ENOG41068WN B7492_30460 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) B7492_30555 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) B7492_30585 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) B7492_30625 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E B7492_30630 ENOG4108D32 Methyltransferase B7492_30645 ENOG4106BHF B7492_30660 ENOG4105DRR Transcriptional regulator, GntR family B7492_30775 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) B7492_30870 ENOG4105EKQ RNA-directed DNA polymerase B7492_30890 ENOG4105DHF Membrane B7492_30950 ENOG4105EKQ RNA-directed DNA polymerase B7492_30960 ENOG4105EKQ RNA-directed DNA polymerase B7492_30965 ENOG4105CNU cell division protein FtsK B7492_30970 ENOG4105VZ8 Transcriptional regulator B7492_30995 ENOG4105D7V transposase B7492_31005 ENOG4105CK5 oxidoreductase B7492_31010 ENOG4105CK5 oxidoreductase B7492_31105 ENOG4105D7V transposase B7492_31165 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B7492_31205 ENOG4107WD8 ABC transporter, permease B7492_31245 ENOG4105D7V transposase B7492_31250 ENOG4108W0I acetyltransferase B7492_31255 ENOG4107QQG Dehydrogenase B7492_31260 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B7492_31265 ENOG4108IAJ Nad-dependent epimerase dehydratase B7492_31270 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B7492_31285 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) B7492_31295 ENOG4105IIU Aminopeptidase B7492_31300 ENOG4108SC4 )-transporter B7492_31310 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B7492_31405 ENOG4105C0H protease B7492_31410 ENOG4105BZU Histidine kinase B7492_31415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7492_31460 ENOG4108M1A Chitin-binding protein B7492_31470 ENOG4105D7V transposase B7492_31475 ENOG4108WZA zeta toxin B7492_31595 ENOG4105K70 DNA-binding protein B7492_31615 ENOG4108IBT Inherit from COG: transposase B7492_31675 ENOG4105C19 ABC transporter B7492_31680 ENOG4107RBB ABC transporter, permease B7492_31925 ENOG4105WFK nuclease B7492_31955 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) B7492_31960 ENOG4105CEY Amp-dependent synthetase and ligase B7492_31970 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C B7492_31980 ENOG4105E1K spore germination protein B7492_32140 ENOG4105KRN Transcriptional regulator, abrb family B7492_32320 ENOG4105EKQ RNA-directed DNA polymerase B7492_32400 ENOG4107QJE Chromosome Partitioning Protein B7492_32435 ENOG4108J59 Extracellular solute-binding protein, family 5 B7492_32480 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B7492_32520 ENOG4108JPW Aminotransferase B7492_32530 ENOG4105CPQ Dehydrogenase B7492_32555 ENOG41086IN PA14 B7492_32565 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) B7492_32600 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B7492_32655 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) B7492_32750 ENOG4105K4H Nlp p60 protein B7492_32890 ENOG4105WH1 Two component transcriptional regulator luxr family B7492_32940 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B7492_33175 ENOG4105KRN Transcriptional regulator, abrb family B7492_33260 ENOG410682Q Phage transcriptional regulator, ArpU B7492_33275 ENOG41067QW Transcriptional regulator B7492_33305 ENOG4107QJE Chromosome Partitioning Protein B7492_33370 ENOG4105DVF Cytosine-specific methyltransferase B7492_33395 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B7492_33420 ENOG410780I phosphoprotein phosphatase activity B7492_33485 ENOG4105C9U ATP-dependent DNA helicase RecQ B7492_33565 ENOG4105DR5 peptidase B7492_33620 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis B7492_33765 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) B7492_33785 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) B7492_33820 ENOG4105EKQ RNA-directed DNA polymerase B7492_33835 ENOG4105IG6 Phage terminase, large subunit B7492_33990 ENOG41067QW Transcriptional regulator B7492_34030 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis B7492_34245 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) B7492_34360 ENOG4105VEQ Cold shock protein